## Load in data generated in the Curation.Rmd file found in the same src folder
load(file = "../output_files/Tissue/Metabo/Metabo_results.R")
load(file="../output_files/Tissue/Metabo/Metabolomics_Pathways.R")
DataMx %>% rownames_to_column(var = "metabolite") -> DataMx
DataMx[,c(1,15:16)] -> DataMx
merge(DataMx,Contrasts,by='metabolite') -> Metabolomics
colnames(Metabolomics) <- c("Biochemical","Superpathway","Subpathway","Log2(FC)","padj")
as.numeric(Metabolomics$`Log2(FC)`) -> Metabolomics$`Log2(FC)`
as.numeric(Metabolomics$padj) -> Metabolomics$padj
Metabolomics %>%
mutate(padj=format(round(padj,2),nsmall=2,scientific=TRUE),
`Log2(FC)`=format(round(`Log2(FC)`,2),nsmall=2,scientific=TRUE)) %>%
kable(caption = "Supplementary Table S1. Effects of ozone on biochemical metabolites", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>%
kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(1:5),bold=ifelse(Metabolomics$padj<.1,T,F),color= ifelse(Metabolomics$padj<.1,spec_color(Metabolomics$`Log2(FC)`,n=11,direction=-1,option='D'),"gray")) %>%
column_spec(c(1:3),width="200px") %>%
column_spec(c(4:5),width="100px") %>%
scroll_box(width = "800px", height = "500px")| Biochemical | Superpathway | Subpathway | Log2(FC) | padj |
|---|---|---|---|---|
| (12 or 13)-methylmyristate (a15:0 or i15:0) | Lipid | Fatty Acid, Branched | -3.20e-01 | 4.7e-01 |
| (14 or 15)-methylpalmitate (a17:0 or i17:0) | Lipid | Fatty Acid, Branched | 4.20e-01 | 1.8e-01 |
| (15 or 16)-methylmargarate (a18:0 or i18:0) | Lipid | Fatty Acid, Branched | -1.70e-01 | 7.4e-01 |
| (16 or 17)-methylstearate (a19:0 or i19:0) | Lipid | Fatty Acid, Branched | 6.10e-01 | 6.0e-02 |
| (2 or 3)-decenoate (10:1n7 or n8) | Lipid | Medium Chain Fatty Acid | 6.40e-01 | 2.0e-02 |
| (N(1) + N(8))-acetylspermidine | Amino Acid | Polyamine Metabolism | 3.00e-01 | 2.0e-02 |
| (R)-3-hydroxybutyrylcarnitine | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Hydroxy) | 1.32e+00 | 0.0e+00 |
| (S)-3-hydroxybutyrylcarnitine | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Hydroxy) | 3.70e-01 | 0.0e+00 |
| 1-(1-enyl-oleoyl)-GPE (P-18:1)* | Lipid | Lysoplasmalogen | 2.50e-01 | 3.8e-01 |
| 1-(1-enyl-palmitoyl)-2-arachidonoyl-GPC (P-16:0/20:4)* | Lipid | Plasmalogen | -2.00e-02 | 8.0e-01 |
| 1-(1-enyl-palmitoyl)-2-arachidonoyl-GPE (P-16:0/20:4)* | Lipid | Plasmalogen | -1.70e-01 | 1.7e-01 |
| 1-(1-enyl-palmitoyl)-2-docosahexaenoyl-GPC (P-16:0/22:6)* | Lipid | Plasmalogen | 1.50e-01 | 2.0e-02 |
| 1-(1-enyl-palmitoyl)-2-docosahexaenoyl-GPE (P-16:0/22:6)* | Lipid | Plasmalogen | -1.90e-01 | 4.0e-02 |
| 1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2)* | Lipid | Plasmalogen | -1.10e-01 | 1.1e-01 |
| 1-(1-enyl-palmitoyl)-2-oleoyl-GPC (P-16:0/18:1)* | Lipid | Plasmalogen | -7.00e-02 | 3.9e-01 |
| 1-(1-enyl-palmitoyl)-2-oleoyl-GPE (P-16:0/18:1)* | Lipid | Plasmalogen | 4.00e-02 | 6.6e-01 |
| 1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0)* | Lipid | Plasmalogen | -1.40e-01 | 8.0e-02 |
| 1-(1-enyl-palmitoyl)-GPC (P-16:0)* | Lipid | Lysoplasmalogen | -5.50e-01 | 0.0e+00 |
| 1-(1-enyl-palmitoyl)-GPE (P-16:0)* | Lipid | Lysoplasmalogen | 1.50e-01 | 5.0e-01 |
| 1-(1-enyl-stearoyl)-2-arachidonoyl-GPE (P-18:0/20:4)* | Lipid | Plasmalogen | 1.40e-01 | 2.1e-01 |
| 1-(1-enyl-stearoyl)-2-docosahexaenoyl-GPC (P-18:0/22:6)* | Lipid | Plasmalogen | 2.20e-01 | 1.0e-02 |
| 1-(1-enyl-stearoyl)-2-docosahexaenoyl-GPE (P-18:0/22:6)* | Lipid | Plasmalogen | 8.00e-02 | 2.5e-01 |
| 1-(1-enyl-stearoyl)-2-linoleoyl-GPE (P-18:0/18:2)* | Lipid | Plasmalogen | 3.00e-02 | 7.4e-01 |
| 1-(1-enyl-stearoyl)-2-oleoyl-GPE (P-18:0/18:1) | Lipid | Plasmalogen | 6.00e-02 | 5.7e-01 |
| 1-(1-enyl-stearoyl)-GPE (P-18:0)* | Lipid | Lysoplasmalogen | 5.00e-02 | 7.8e-01 |
| 1-adrenoyl-GPC (22:4)* | Lipid | Lysophospholipid | -9.70e-01 | 0.0e+00 |
| 1-arachidonoyl-GPC (20:4n6)* | Lipid | Lysophospholipid | -5.80e-01 | 0.0e+00 |
| 1-arachidonoyl-GPE (20:4n6)* | Lipid | Lysophospholipid | -1.90e-01 | 3.0e-02 |
| 1-arachidonoyl-GPI (20:4)* | Lipid | Lysophospholipid | 7.00e-02 | 6.1e-01 |
| 1-arachidonylglycerol (20:4) | Lipid | Monoacylglycerol | 1.40e-01 | 5.1e-01 |
| 1-arachidoyl-2-arachidonoyl-GPC (20:0/20:4)* | Lipid | Phosphatidylcholine (PC) | 4.50e-01 | 0.0e+00 |
| 1-arachidoyl-GPC (20:0) | Lipid | Lysophospholipid | -1.30e-01 | 1.1e-01 |
| 1-behenoyl-GPC (22:0) | Lipid | Lysophospholipid | 5.00e-02 | 3.7e-01 |
| 1-dihomo-linolenoyl-GPC (20:3n3 or 6)* | Lipid | Lysophospholipid | -7.90e-01 | 0.0e+00 |
| 1-dihomo-linolenylglycerol (20:3) | Lipid | Monoacylglycerol | 6.80e-01 | 7.0e-02 |
| 1-dihomo-linoleoyl-GPC (20:2)* | Lipid | Lysophospholipid | -5.90e-01 | 0.0e+00 |
| 1-dihomo-linoleoylglycerol (20:2) | Lipid | Monoacylglycerol | 9.30e-01 | 7.0e-02 |
| 1-docosahexaenoyl-GPC (22:6)* | Lipid | Lysophospholipid | -7.90e-01 | 0.0e+00 |
| 1-docosahexaenoyl-GPE (22:6)* | Lipid | Lysophospholipid | -4.20e-01 | 0.0e+00 |
| 1-docosahexaenoylglycerol (22:6) | Lipid | Monoacylglycerol | 6.50e-01 | 9.0e-02 |
| 1-eicosapentaenoyl-GPC (20:5)* | Lipid | Lysophospholipid | -6.20e-01 | 0.0e+00 |
| 1-eicosapentaenoyl-GPE (20:5)* | Lipid | Lysophospholipid | -5.20e-01 | 4.0e-02 |
| 1-eicosapentaenoylglycerol (20:5)* | Lipid | Monoacylglycerol | 1.32e+00 | 1.0e-02 |
| 1-eicosenoyl-GPC (20:1)* | Lipid | Lysophospholipid | -5.00e-01 | 0.0e+00 |
| 1-erucoyl-GPC (22:1)* | Lipid | Lysophospholipid | -3.20e-01 | 0.0e+00 |
| 1-heneicosanoyl-GPC (21:0)* | Lipid | Lysophospholipid | -1.20e-01 | 3.1e-01 |
| 1-lignoceroyl-GPC (24:0) | Lipid | Lysophospholipid | 1.30e-01 | 2.0e-02 |
| 1-linolenoyl-GPC (18:3)* | Lipid | Lysophospholipid | -3.20e-01 | 1.0e-02 |
| 1-linolenoylglycerol (18:3) | Lipid | Monoacylglycerol | 8.90e-01 | 3.0e-02 |
| 1-linoleoyl-2-arachidonoyl-GPC (18:2/20:4n6)* | Lipid | Phosphatidylcholine (PC) | 4.30e-01 | 0.0e+00 |
| 1-linoleoyl-2-arachidonoyl-GPE (18:2/20:4)* | Lipid | Phosphatidylethanolamine (PE) | -1.50e-01 | 8.1e-01 |
| 1-linoleoyl-2-linolenoyl-GPC (18:2/18:3)* | Lipid | Phosphatidylcholine (PC) | 1.20e-01 | 3.5e-01 |
| 1-linoleoyl-GPC (18:2) | Lipid | Lysophospholipid | -6.40e-01 | 0.0e+00 |
| 1-linoleoyl-GPE (18:2)* | Lipid | Lysophospholipid | -7.90e-01 | 0.0e+00 |
| 1-linoleoyl-GPG (18:2)* | Lipid | Lysophospholipid | 5.50e-01 | 7.0e-02 |
| 1-linoleoyl-GPI (18:2)* | Lipid | Lysophospholipid | -2.20e-01 | 5.6e-01 |
| 1-linoleoyl-GPS (18:2)* | Lipid | Lysophospholipid | 4.50e-01 | 1.9e-01 |
| 1-linoleoylglycerol (18:2) | Lipid | Monoacylglycerol | 7.20e-01 | 2.0e-02 |
| 1-margaroyl-2-arachidonoyl-GPC (17:0/20:4)* | Lipid | Phosphatidylcholine (PC) | 5.40e-01 | 0.0e+00 |
| 1-margaroyl-2-linoleoyl-GPC (17:0/18:2)* | Lipid | Phosphatidylcholine (PC) | 2.70e-01 | 1.0e-02 |
| 1-margaroyl-2-oleoyl-GPC (17:0/18:1)* | Lipid | Phosphatidylcholine (PC) | 3.20e-01 | 0.0e+00 |
| 1-margaroyl-GPE (17:0)* | Lipid | Lysophospholipid | -4.10e-01 | 0.0e+00 |
| 1-methyl-4-imidazoleacetate | Amino Acid | Histidine Metabolism | -1.05e+00 | 0.0e+00 |
| 1-methyl-5-imidazoleacetate | Amino Acid | Histidine Metabolism | -7.10e-01 | 1.0e-02 |
| 1-methylguanidine | Amino Acid | Guanidino and Acetamido Metabolism | -5.00e-01 | 5.1e-01 |
| 1-methylhistamine | Amino Acid | Histidine Metabolism | -2.20e-01 | 5.7e-01 |
| 1-methylhistidine | Amino Acid | Histidine Metabolism | -2.50e-01 | 1.7e-01 |
| 1-methylhypoxanthine | Nucleotide | Purine Metabolism, (Hypo)Xanthine/Inosine containing | -6.00e-02 | 6.0e-01 |
| 1-methylnicotinamide | Cofactors and Vitamins | Nicotinate and Nicotinamide Metabolism | 1.05e+00 | 0.0e+00 |
| 1-myristoyl-2-arachidonoyl-GPC (14:0/20:4)* | Lipid | Phosphatidylcholine (PC) | 4.80e-01 | 0.0e+00 |
| 1-myristoyl-2-palmitoyl-GPC (14:0/16:0) | Lipid | Phosphatidylcholine (PC) | -7.00e-02 | 5.0e-01 |
| 1-myristoyl-GPC (14:0) | Lipid | Lysophospholipid | 0.00e+00 | 9.4e-01 |
| 1-nervonoyl-GPC (24:1n9)* | Lipid | Lysophospholipid | -7.00e-02 | 3.5e-01 |
| 1-nonadecanoyl-GPC (19:0) | Lipid | Lysophospholipid | -6.00e-02 | 5.2e-01 |
| 1-nonadecenoyl-GPC (19:1)* | Lipid | Lysophospholipid | -2.50e-01 | 5.0e-02 |
| 1-oleoyl-2-arachidonoyl-GPE (18:1/20:4)* | Lipid | Phosphatidylethanolamine (PE) | 6.20e-01 | 7.0e-02 |
| 1-oleoyl-2-docosahexaenoyl-GPC (18:1/22:6)* | Lipid | Phosphatidylcholine (PC) | 5.30e-01 | 0.0e+00 |
| 1-oleoyl-2-linoleoyl-GPC (18:1/18:2)* | Lipid | Phosphatidylcholine (PC) | -1.20e-01 | 5.7e-01 |
| 1-oleoyl-2-linoleoyl-GPI (18:1/18:2)* | Lipid | Phosphatidylinositol (PI) | 1.70e-01 | 1.0e-01 |
| 1-oleoyl-GPC (18:1) | Lipid | Lysophospholipid | -3.50e-01 | 0.0e+00 |
| 1-oleoyl-GPE (18:1) | Lipid | Lysophospholipid | -1.90e-01 | 1.8e-01 |
| 1-oleoyl-GPI (18:1) | Lipid | Lysophospholipid | -6.40e-01 | 8.0e-02 |
| 1-oleoyl-GPS (18:1) | Lipid | Lysophospholipid | 8.00e-02 | 6.8e-01 |
| 1-oleoylglycerol (18:1) | Lipid | Monoacylglycerol | 2.40e-01 | 3.5e-01 |
| 1-palmitoleoyl-2-linolenoyl-GPC (16:1/18:3)* | Lipid | Phosphatidylcholine (PC) | 5.00e-01 | 6.0e-02 |
| 1-palmitoleoyl-2-linoleoyl-GPC (16:1/18:2)* | Lipid | Phosphatidylcholine (PC) | -5.00e-02 | 9.3e-01 |
| 1-palmitoleoyl-GPC (16:1)* | Lipid | Lysophospholipid | -2.30e-01 | 6.0e-02 |
| 1-palmitoleoylglycerol (16:1)* | Lipid | Monoacylglycerol | 1.18e+00 | 2.0e-02 |
| 1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6) | Lipid | Phosphatidylcholine (PC) | 3.20e-01 | 0.0e+00 |
| 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4)* | Lipid | Phosphatidylethanolamine (PE) | -2.00e-02 | 9.1e-01 |
| 1-palmitoyl-2-arachidonoyl-GPI (16:0/20:4)* | Lipid | Phosphatidylinositol (PI) | 3.00e-01 | 0.0e+00 |
| 1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6) | Lipid | Phosphatidylcholine (PC) | 5.20e-01 | 0.0e+00 |
| 1-palmitoyl-2-docosahexaenoyl-GPE (16:0/22:6)* | Lipid | Phosphatidylethanolamine (PE) | -1.90e-01 | 4.1e-01 |
| 1-palmitoyl-2-eicosapentaenoyl-GPC (16:0/20:5)* | Lipid | Phosphatidylcholine (PC) | 4.90e-01 | 0.0e+00 |
| 1-palmitoyl-2-gamma-linolenoyl-GPC (16:0/18:3n6)* | Lipid | Phosphatidylcholine (PC) | 8.00e-01 | 0.0e+00 |
| 1-palmitoyl-2-linoleoyl-GPC (16:0/18:2) | Lipid | Phosphatidylcholine (PC) | 8.00e-02 | 1.8e-01 |
| 1-palmitoyl-2-linoleoyl-GPE (16:0/18:2) | Lipid | Phosphatidylethanolamine (PE) | -5.30e-01 | 0.0e+00 |
| 1-palmitoyl-2-linoleoyl-GPI (16:0/18:2) | Lipid | Phosphatidylinositol (PI) | 2.30e-01 | 5.0e-02 |
| 1-palmitoyl-2-oleoyl-GPC (16:0/18:1) | Lipid | Phosphatidylcholine (PC) | 3.60e-01 | 0.0e+00 |
| 1-palmitoyl-2-oleoyl-GPE (16:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | 1.90e-01 | 2.1e-01 |
| 1-palmitoyl-2-oleoyl-GPI (16:0/18:1)* | Lipid | Phosphatidylinositol (PI) | 9.00e-02 | 4.5e-01 |
| 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1)* | Lipid | Phosphatidylcholine (PC) | 3.50e-01 | 0.0e+00 |
| 1-palmitoyl-2-pentadecanoyl-GPC (16:0/15:0)* | Lipid | Phosphatidylcholine (PC) | -4.00e-02 | 7.3e-01 |
| 1-palmitoyl-2-stearoyl-GPC (16:0/18:0) | Lipid | Phosphatidylcholine (PC) | -1.40e-01 | 1.6e-01 |
| 1-palmitoyl-GPA (16:0) | Lipid | Lysophospholipid | -1.40e-01 | 8.4e-01 |
| 1-palmitoyl-GPC (16:0) | Lipid | Lysophospholipid | -9.00e-02 | 1.8e-01 |
| 1-palmitoyl-GPE (16:0) | Lipid | Lysophospholipid | -3.70e-01 | 0.0e+00 |
| 1-palmitoyl-GPI (16:0) | Lipid | Lysophospholipid | -1.40e-01 | 7.7e-01 |
| 1-palmitoylglycerol (16:0) | Lipid | Monoacylglycerol | 1.70e-01 | 5.5e-01 |
| 1-palmityl-2-linoleoyl-GPC (O-16:0/18:2)* | Lipid | Plasmalogen | -6.00e-02 | 5.4e-01 |
| 1-palmityl-2-palmitoyl-GPC (O-16:0/16:0)* | Lipid | Plasmalogen | -4.00e-02 | 6.4e-01 |
| 1-palmityl-2-stearoyl-GPC (O-16:0/18:0)* | Lipid | Plasmalogen | -6.00e-02 | 5.1e-01 |
| 1-palmityl-GPC (O-16:0) | Lipid | Lysoplasmalogen | -2.90e-01 | 2.0e-02 |
| 1-palmityl-GPE (O-16:0)* | Lipid | Lysoplasmalogen | 3.00e-01 | 2.7e-01 |
| 1-pentadecanoyl-2-arachidonoyl-GPC (15:0/20:4)* | Lipid | Phosphatidylcholine (PC) | 4.00e-01 | 0.0e+00 |
| 1-pentadecanoyl-2-docosahexaenoyl-GPC (15:0/22:6)* | Lipid | Phosphatidylcholine (PC) | 4.30e-01 | 0.0e+00 |
| 1-pentadecanoyl-2-linoleoyl-GPC (15:0/18:2)* | Lipid | Phosphatidylcholine (PC) | 1.40e-01 | 2.4e-01 |
| 1-pentadecanoyl-GPC (15:0)* | Lipid | Lysophospholipid | -2.10e-01 | 1.8e-01 |
| 1-ribosyl-imidazoleacetate* | Amino Acid | Histidine Metabolism | -2.60e-01 | 4.0e-02 |
| 1-stearoyl-2-adrenoyl-GPC (18:0/22:4)* | Lipid | Phosphatidylcholine (PC) | 3.50e-01 | 0.0e+00 |
| 1-stearoyl-2-arachidonoyl-GPC (18:0/20:4) | Lipid | Phosphatidylcholine (PC) | 3.00e-01 | 0.0e+00 |
| 1-stearoyl-2-arachidonoyl-GPE (18:0/20:4) | Lipid | Phosphatidylethanolamine (PE) | 6.00e-02 | 5.1e-01 |
| 1-stearoyl-2-arachidonoyl-GPI (18:0/20:4) | Lipid | Phosphatidylinositol (PI) | 4.20e-01 | 0.0e+00 |
| 1-stearoyl-2-arachidonoyl-GPS (18:0/20:4) | Lipid | Phosphatidylserine (PS) | -4.00e-02 | 7.4e-01 |
| 1-stearoyl-2-dihomo-linolenoyl-GPC (18:0/20:3n3 or 6)* | Lipid | Phosphatidylcholine (PC) | 5.00e-01 | 0.0e+00 |
| 1-stearoyl-2-dihomo-linolenoyl-GPI (18:0/20:3n3 or 6)* | Lipid | Phosphatidylinositol (PI) | 9.50e-01 | 0.0e+00 |
| 1-stearoyl-2-docosahexaenoyl-GPC (18:0/22:6) | Lipid | Phosphatidylcholine (PC) | 4.80e-01 | 0.0e+00 |
| 1-stearoyl-2-docosahexaenoyl-GPI (18:0/22:6)* | Lipid | Phosphatidylinositol (PI) | 8.60e-01 | 0.0e+00 |
| 1-stearoyl-2-docosapentaenoyl-GPC (18:0/22:5n3)* | Lipid | Phosphatidylcholine (PC) | 3.60e-01 | 1.0e-02 |
| 1-stearoyl-2-docosapentaenoyl-GPC (18:0/22:5n6)* | Lipid | Phosphatidylcholine (PC) | 2.40e-01 | 2.1e-01 |
| 1-stearoyl-2-linoleoyl-GPC (18:0/18:2)* | Lipid | Phosphatidylcholine (PC) | 1.90e-01 | 0.0e+00 |
| 1-stearoyl-2-linoleoyl-GPE (18:0/18:2)* | Lipid | Phosphatidylethanolamine (PE) | -4.40e-01 | 3.0e-02 |
| 1-stearoyl-2-linoleoyl-GPI (18:0/18:2) | Lipid | Phosphatidylinositol (PI) | 4.60e-01 | 0.0e+00 |
| 1-stearoyl-2-meadoyl-GPC (18:0/20:3n9)* | Lipid | Phosphatidylcholine (PC) | 1.70e-01 | 4.3e-01 |
| 1-stearoyl-2-oleoyl-GPC (18:0/18:1) | Lipid | Phosphatidylcholine (PC) | 4.20e-01 | 0.0e+00 |
| 1-stearoyl-2-oleoyl-GPE (18:0/18:1) | Lipid | Phosphatidylethanolamine (PE) | -3.10e-01 | 1.8e-01 |
| 1-stearoyl-GPC (18:0) | Lipid | Lysophospholipid | -6.00e-02 | 4.1e-01 |
| 1-stearoyl-GPE (18:0) | Lipid | Lysophospholipid | -3.50e-01 | 0.0e+00 |
| 1-stearoyl-GPI (18:0) | Lipid | Lysophospholipid | 3.30e-01 | 1.5e-01 |
| 1-stearoyl-GPS (18:0)* | Lipid | Lysophospholipid | 5.30e-01 | 1.9e-01 |
| 1-stearyl-2-arachidonoyl-GPC (O-18:0/20:4)* | Lipid | Plasmalogen | -8.00e-02 | 3.7e-01 |
| 1-stearyl-GPC (O-18:0)* | Lipid | Lysoplasmalogen | -2.40e-01 | 8.0e-02 |
| 1-stearyl-GPE (O-18:0)* | Lipid | Lysoplasmalogen | 2.50e-01 | 3.3e-01 |
| 1-tricosanoyl-GPC (23:0)* | Lipid | Lysophospholipid | 5.00e-02 | 5.8e-01 |
| 1,2-dilinoleoyl-GPC (18:2/18:2) | Lipid | Phosphatidylcholine (PC) | -1.00e-02 | 9.1e-01 |
| 1,2-dipalmitoyl-GPC (16:0/16:0) | Lipid | Phosphatidylcholine (PC) | -1.70e-01 | 3.0e-02 |
| 1,2-distearoyl-GPC (18:0/18:0) | Lipid | Phosphatidylcholine (PC) | -3.40e-01 | 0.0e+00 |
| 1,5-anhydroglucitol (1,5-AG) | Carbohydrate | Glycolysis, Gluconeogenesis, and Pyruvate Metabolism | -2.10e-01 | 1.7e-01 |
| 10-heptadecenoate (17:1n7) | Lipid | Long Chain Monounsaturated Fatty Acid | 7.10e-01 | 2.0e-02 |
| 10-nonadecenoate (19:1n9) | Lipid | Long Chain Monounsaturated Fatty Acid | 6.70e-01 | 6.0e-02 |
| 10-undecenoate (11:1n1) | Lipid | Medium Chain Fatty Acid | -3.00e-02 | 9.6e-01 |
| 11-dehydrocorticosterone | Lipid | Corticosteroids | 4.00e-02 | 6.2e-01 |
| 12-HEPE | Lipid | Eicosanoid | 1.48e+00 | 0.0e+00 |
| 12-HETE | Lipid | Eicosanoid | 9.80e-01 | 1.0e-02 |
| 12-HHTrE | Lipid | Eicosanoid | 3.50e-01 | 2.7e-01 |
| 12-ketolithocholate | Lipid | Secondary Bile Acid Metabolism | -1.78e+00 | 3.0e-02 |
| 12,13-DiHOME | Lipid | Fatty Acid, Dihydroxy | 2.00e-02 | 8.3e-01 |
| 13-HODE + 9-HODE | Lipid | Fatty Acid, Monohydroxy | 3.90e-01 | 4.0e-02 |
| 14-HDoHE/17-HDoHE | Lipid | Docosanoid | 1.44e+00 | 0.0e+00 |
| 16-hydroxypalmitate | Lipid | Fatty Acid, Monohydroxy | 7.40e-01 | 0.0e+00 |
| 18-methylnonadecanoate (i20:0) | Lipid | Fatty Acid, Branched | 7.30e-01 | 0.0e+00 |
| 2’-deoxycytidine | Nucleotide | Pyrimidine Metabolism, Cytidine containing | 1.00e-02 | 7.2e-01 |
| 2’-deoxyuridine | Nucleotide | Pyrimidine Metabolism, Uracil containing | 1.00e-01 | 2.8e-01 |
| 2’-O-methylcytidine | Nucleotide | Pyrimidine Metabolism, Cytidine containing | -1.30e-01 | 3.6e-01 |
| 2’-O-methyluridine | Nucleotide | Pyrimidine Metabolism, Uracil containing | -2.30e-01 | 5.0e-02 |
| 2-(4-hydroxyphenyl)propionate | Xenobiotics | Benzoate Metabolism | -9.90e-01 | 0.0e+00 |
| 2-aminoadipate | Amino Acid | Lysine Metabolism | -3.90e-01 | 3.0e-02 |
| 2-aminobutyrate | Amino Acid | Glutathione Metabolism | 1.39e+00 | 0.0e+00 |
| 2-aminoheptanoate | Lipid | Fatty Acid, Amino | 0.00e+00 | 9.7e-01 |
| 2-aminophenol sulfate | Xenobiotics | Food Component/Plant | -5.50e-01 | 5.0e-02 |
| 2-arachidonoylglycerol (20:4) | Lipid | Monoacylglycerol | -2.00e-02 | 7.4e-01 |
| 2-hydroxy-3-methylvalerate | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 5.10e-01 | 0.0e+00 |
| 2-hydroxy-4-(methylthio)butanoic acid | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | -1.68e+00 | 0.0e+00 |
| 2-hydroxyarachidate* | Lipid | Fatty Acid, Monohydroxy | 6.00e-01 | 7.0e-02 |
| 2-hydroxybehenate | Lipid | Fatty Acid, Monohydroxy | 7.00e-01 | 1.0e-02 |
| 2-hydroxybutyrate/2-hydroxyisobutyrate | Amino Acid | Glutathione Metabolism | 1.32e+00 | 0.0e+00 |
| 2-hydroxydecanoate | Lipid | Fatty Acid, Monohydroxy | -2.10e-01 | 2.2e-01 |
| 2-hydroxyglutarate | Lipid | Fatty Acid, Dicarboxylate | -4.00e-01 | 6.0e-02 |
| 2-hydroxyhippurate (salicylurate) | Xenobiotics | Benzoate Metabolism | -4.50e-01 | 3.9e-01 |
| 2-hydroxyoctanoate | Lipid | Fatty Acid, Monohydroxy | -4.20e-01 | 3.3e-01 |
| 2-hydroxypalmitate | Lipid | Fatty Acid, Monohydroxy | 5.50e-01 | 4.0e-02 |
| 2-hydroxysebacate | Lipid | Fatty Acid, Dicarboxylate | -5.00e-02 | 8.4e-01 |
| 2-hydroxystearate | Lipid | Fatty Acid, Monohydroxy | 4.60e-01 | 8.0e-02 |
| 2-linoleoylglycerol (18:2) | Lipid | Monoacylglycerol | 4.70e-01 | 1.7e-01 |
| 2-methylbutyrylcarnitine (C5) | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 2.20e-01 | 1.2e-01 |
| 2-methylbutyrylglycine | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 1.00e+00 | 0.0e+00 |
| 2-methylcitrate/homocitrate | Energy | TCA Cycle | -3.70e-01 | 4.0e-02 |
| 2-methylserine | Amino Acid | Glycine, Serine and Threonine Metabolism | 2.10e-01 | 1.3e-01 |
| 2-myristoyl-GPC (14:0)* | Lipid | Lysophospholipid | 0.00e+00 | 8.5e-01 |
| 2-O-methylascorbic acid | Cofactors and Vitamins | Ascorbate and Aldarate Metabolism | -1.40e-01 | 2.2e-01 |
| 2-oleoylglycerol (18:1) | Lipid | Monoacylglycerol | -1.30e-01 | 8.7e-01 |
| 2-oxindole-3-acetate | Xenobiotics | Food Component/Plant | -1.08e+00 | 1.8e-01 |
| 2-oxo-1-pyrrolidinepropionate | Xenobiotics | Chemical | -1.93e+00 | 0.0e+00 |
| 2-oxoadipate | Amino Acid | Lysine Metabolism | 5.30e-01 | 0.0e+00 |
| 2-oxoarginine* | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -1.56e+00 | 0.0e+00 |
| 2-palmitoyl-GPC (16:0)* | Lipid | Lysophospholipid | 2.40e-01 | 3.5e-01 |
| 2-pyrrolidinone | Amino Acid | Glutamate Metabolism | -6.10e-01 | 2.4e-01 |
| 2-stearoyl-GPE (18:0)* | Lipid | Lysophospholipid | -5.40e-01 | 8.0e-02 |
| 2-stearoyl-GPI (18:0)* | Lipid | Lysophospholipid | -1.00e-02 | 9.1e-01 |
| 2,2’-methylenebis(6-tert-butyl-p-cresol) | Xenobiotics | Chemical | 1.80e-01 | 3.5e-01 |
| 2,3-dihydroxy-2-methylbutyrate | Amino Acid | Leucine, Isoleucine and Valine Metabolism | -1.70e-01 | 8.3e-01 |
| 2,3-dihydroxy-5-methylthio-4-pentenoate (DMTPA)* | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | -2.60e-01 | 4.0e-02 |
| 2,3-dihydroxyisovalerate | Xenobiotics | Food Component/Plant | -4.50e-01 | 1.0e-02 |
| 2,4-di-tert-butylphenol | Xenobiotics | Chemical | 4.90e-01 | 9.0e-02 |
| 2,4-dihydroxybutyrate | Lipid | Fatty Acid, Dihydroxy | -5.30e-01 | 0.0e+00 |
| 2,6-dihydroxybenzoic acid | Xenobiotics | Drug - Topical Agents | -7.00e-01 | 1.0e-02 |
| 2,8-quinolinediol sulfate | Xenobiotics | Food Component/Plant | -1.44e+00 | 0.0e+00 |
| 2R,3R-dihydroxybutyrate | Lipid | Fatty Acid, Dihydroxy | -1.00e-01 | 3.7e-01 |
| 2S,3R-dihydroxybutyrate | Lipid | Fatty Acid, Dihydroxy | 1.09e+00 | 0.0e+00 |
| 3’-sialyllactose | Carbohydrate | Disaccharides and Oligosaccharides | -1.38e+00 | 0.0e+00 |
| 3-(3-amino-3-carboxypropyl)uridine* | Nucleotide | Pyrimidine Metabolism, Uracil containing | -4.70e-01 | 0.0e+00 |
| 3-(3-hydroxyphenyl)propionate | Xenobiotics | Benzoate Metabolism | -1.57e+00 | 2.0e-02 |
| 3-(3-hydroxyphenyl)propionate sulfate | Xenobiotics | Benzoate Metabolism | -2.07e+00 | 0.0e+00 |
| 3-(4-hydroxyphenyl)lactate | Amino Acid | Tyrosine Metabolism | -3.70e-01 | 0.0e+00 |
| 3-(4-hydroxyphenyl)propionate | Xenobiotics | Benzoate Metabolism | -1.30e+00 | 4.0e-02 |
| 3-amino-2-piperidone | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -1.20e-01 | 6.4e-01 |
| 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-CMPFP)** | Lipid | Fatty Acid, Dicarboxylate | -1.70e-01 | 8.0e-02 |
| 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (CMPF) | Lipid | Fatty Acid, Dicarboxylate | -1.90e-01 | 9.7e-01 |
| 3-dehydrocholate | Lipid | Secondary Bile Acid Metabolism | -3.70e-01 | 8.7e-01 |
| 3-formylindole | Xenobiotics | Food Component/Plant | 1.30e-01 | 2.1e-01 |
| 3-hydroxy-2-ethylpropionate | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 8.20e-01 | 0.0e+00 |
| 3-hydroxy-2-methylpyridine sulfate | Xenobiotics | Chemical | -7.00e-01 | 8.0e-02 |
| 3-hydroxy-3-methylglutarate | Lipid | Mevalonate Metabolism | 4.10e-01 | 2.0e-02 |
| 3-hydroxyadipate | Lipid | Fatty Acid, Dicarboxylate | 1.17e+00 | 0.0e+00 |
| 3-hydroxybutyrate (BHBA) | Lipid | Ketone Bodies | 4.50e-01 | 0.0e+00 |
| 3-hydroxycinnamate sulfate | Xenobiotics | Food Component/Plant | -2.47e+00 | 0.0e+00 |
| 3-hydroxydecanoate | Lipid | Fatty Acid, Monohydroxy | 1.80e-01 | 8.0e-02 |
| 3-hydroxydecanoylcarnitine | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Hydroxy) | -1.30e-01 | 9.1e-01 |
| 3-hydroxyhexanoate | Lipid | Fatty Acid, Monohydroxy | -6.40e-01 | 2.6e-01 |
| 3-hydroxyhexanoylcarnitine (1) | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Hydroxy) | -1.60e-01 | 6.0e-01 |
| 3-hydroxyhippurate | Xenobiotics | Benzoate Metabolism | -7.30e-01 | 1.0e-01 |
| 3-hydroxyindolin-2-one sulfate | Xenobiotics | Food Component/Plant | -1.19e+00 | 1.0e-02 |
| 3-hydroxyisobutyrate | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 6.10e-01 | 3.0e-02 |
| 3-hydroxylaurate | Lipid | Fatty Acid, Monohydroxy | 5.90e-01 | 0.0e+00 |
| 3-hydroxymyristate | Lipid | Fatty Acid, Monohydroxy | 6.40e-01 | 0.0e+00 |
| 3-hydroxyoctanoate | Lipid | Fatty Acid, Monohydroxy | -4.40e-01 | 4.4e-01 |
| 3-hydroxyoctanoylcarnitine (1) | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Hydroxy) | -9.00e-02 | 8.9e-01 |
| 3-hydroxyoleoylcarnitine | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Hydroxy) | 3.90e-01 | 3.0e-02 |
| 3-hydroxypalmitoylcarnitine | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Hydroxy) | 7.70e-01 | 0.0e+00 |
| 3-hydroxypyridine sulfate | Xenobiotics | Chemical | -8.00e-01 | 2.0e-02 |
| 3-hydroxysebacate | Lipid | Fatty Acid, Monohydroxy | 4.40e-01 | 1.0e-01 |
| 3-hydroxystearate | Lipid | Fatty Acid, Monohydroxy | 5.70e-01 | 6.0e-02 |
| 3-indoleglyoxylic acid | Xenobiotics | Food Component/Plant | -1.60e-01 | 2.4e-01 |
| 3-indoxyl sulfate | Amino Acid | Tryptophan Metabolism | -9.80e-01 | 0.0e+00 |
| 3-methoxytyrosine | Amino Acid | Tyrosine Metabolism | -1.00e-01 | 4.6e-01 |
| 3-methyl-2-oxobutyrate | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 5.20e-01 | 0.0e+00 |
| 3-methyl-2-oxovalerate | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 5.20e-01 | 0.0e+00 |
| 3-methyladipate | Lipid | Fatty Acid, Dicarboxylate | -2.60e-01 | 5.3e-01 |
| 3-methylcrotonylglycine | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 9.50e-01 | 0.0e+00 |
| 3-methylglutaconate | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 5.00e-02 | 5.5e-01 |
| 3-methylhistidine | Amino Acid | Histidine Metabolism | -5.80e-01 | 0.0e+00 |
| 3-phenylpropionate (hydrocinnamate) | Xenobiotics | Benzoate Metabolism | -4.20e-01 | 1.2e-01 |
| 3-ureidopropionate | Nucleotide | Pyrimidine Metabolism, Uracil containing | -1.00e-02 | 8.8e-01 |
| 3,4-dihydroxybutyrate | Lipid | Fatty Acid, Dihydroxy | -4.20e-01 | 0.0e+00 |
| 3beta,7alpha-dihydroxy-5-cholestenoate | Lipid | Sterol | 1.50e-01 | 4.3e-01 |
| 4-acetamidobenzoate | Xenobiotics | Chemical | -1.60e-01 | 8.3e-01 |
| 4-acetamidobutanoate | Amino Acid | Polyamine Metabolism | -2.00e-02 | 8.9e-01 |
| 4-acetylphenol sulfate | Xenobiotics | Benzoate Metabolism | -8.70e-01 | 1.0e-02 |
| 4-allylcatechol sulfate | Xenobiotics | Benzoate Metabolism | -1.02e+00 | 1.2e-01 |
| 4-allylphenol sulfate | Xenobiotics | Food Component/Plant | -9.70e-01 | 0.0e+00 |
| 4-cholesten-3-one | Lipid | Sterol | 1.70e-01 | 3.0e-01 |
| 4-ethylcatechol sulfate | Xenobiotics | Benzoate Metabolism | -9.10e-01 | 0.0e+00 |
| 4-ethylphenol glucuronide | Xenobiotics | Benzoate Metabolism | -7.10e-01 | 1.0e-02 |
| 4-ethylphenylsulfate | Xenobiotics | Benzoate Metabolism | -6.10e-01 | 0.0e+00 |
| 4-guanidinobutanoate | Amino Acid | Guanidino and Acetamido Metabolism | -6.20e-01 | 2.0e-02 |
| 4-hydroxybenzoate | Xenobiotics | Benzoate Metabolism | -8.20e-01 | 1.0e-01 |
| 4-hydroxybutyrate (GHB) | Lipid | Fatty Acid, Monohydroxy | 6.40e-01 | 0.0e+00 |
| 4-hydroxycinnamate sulfate | Amino Acid | Tyrosine Metabolism | -1.73e+00 | 0.0e+00 |
| 4-hydroxycoumarin | Xenobiotics | Drug - Cardiovascular | -1.77e+00 | 0.0e+00 |
| 4-hydroxyglutamate | Amino Acid | Glutamate Metabolism | -4.40e-01 | 2.4e-01 |
| 4-hydroxyhippurate | Xenobiotics | Benzoate Metabolism | -4.30e-01 | 2.4e-01 |
| 4-hydroxyphenylacetylglycine | Peptide | Acetylated Peptides | -6.80e-01 | 1.0e-02 |
| 4-imidazoleacetate | Amino Acid | Histidine Metabolism | -1.00e-01 | 3.4e-01 |
| 4-methyl-2-oxopentanoate | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 6.20e-01 | 0.0e+00 |
| 4-methylbenzenesulfonate | Xenobiotics | Chemical | -1.35e+00 | 7.0e-02 |
| 4-methylcatechol sulfate | Xenobiotics | Benzoate Metabolism | -4.20e-01 | 3.6e-01 |
| 4-vinylphenol sulfate | Xenobiotics | Benzoate Metabolism | -8.70e-01 | 0.0e+00 |
| 5-(galactosylhydroxy)-lysine | Amino Acid | Lysine Metabolism | -4.40e-01 | 4.0e-02 |
| 5-aminovalerate | Amino Acid | Lysine Metabolism | -6.70e-01 | 4.9e-01 |
| 5-dodecenoylcarnitine (C12:1) | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Monounsaturated) | -6.00e-02 | 9.9e-01 |
| 5-hydroxyhexanoate | Lipid | Fatty Acid, Monohydroxy | -2.10e-01 | 3.8e-01 |
| 5-hydroxyindoleacetate | Amino Acid | Tryptophan Metabolism | 3.00e-02 | 6.5e-01 |
| 5-hydroxylysine | Amino Acid | Lysine Metabolism | -6.30e-01 | 0.0e+00 |
| 5-methyl-2’-deoxycytidine | Nucleotide | Pyrimidine Metabolism, Cytidine containing | -8.90e-01 | 0.0e+00 |
| 5-methylcytidine | Nucleotide | Pyrimidine Metabolism, Cytidine containing | -2.30e-01 | 0.0e+00 |
| 5-methylthioadenosine (MTA) | Amino Acid | Polyamine Metabolism | -3.60e-01 | 4.0e-02 |
| 5-methylthioribose** | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | -1.07e+00 | 0.0e+00 |
| 5-methyluridine (ribothymidine) | Nucleotide | Pyrimidine Metabolism, Uracil containing | -2.00e-01 | 5.0e-02 |
| 5-oxoproline | Amino Acid | Glutathione Metabolism | -1.40e-01 | 6.0e-02 |
| 5,6-dihydrothymine | Nucleotide | Pyrimidine Metabolism, Thymine containing | 6.00e-01 | 1.3e-01 |
| 5,6-dihydrouridine | Nucleotide | Pyrimidine Metabolism, Uracil containing | -3.90e-01 | 0.0e+00 |
| 6-acetylglucose | Xenobiotics | Chemical | 5.00e-01 | 0.0e+00 |
| 6-bromotryptophan | Amino Acid | Tryptophan Metabolism | -1.30e-01 | 2.6e-01 |
| 6-hydroxyindole sulfate | Xenobiotics | Chemical | -9.40e-01 | 0.0e+00 |
| 6-oxolithocholate | Lipid | Secondary Bile Acid Metabolism | -9.70e-01 | 3.0e-02 |
| 6-oxopiperidine-2-carboxylate | Amino Acid | Lysine Metabolism | 9.00e-02 | 4.5e-01 |
| 6beta-hydroxylithocholate | Lipid | Secondary Bile Acid Metabolism | -1.41e+00 | 1.0e-02 |
| 7-hydroxyindole sulfate | Amino Acid | Tryptophan Metabolism | -7.60e-01 | 9.0e-02 |
| 7-ketodeoxycholate | Lipid | Secondary Bile Acid Metabolism | -1.29e+00 | 1.6e-01 |
| 7-methylguanine | Nucleotide | Purine Metabolism, Guanine containing | -1.00e-02 | 9.7e-01 |
| 7alpha-hydroxy-3-oxo-4-cholestenoate (7-Hoca) | Lipid | Sterol | 1.20e-01 | 3.9e-01 |
| 8-hydroxyoctanoate | Lipid | Fatty Acid, Monohydroxy | -5.90e-01 | 1.0e-02 |
| 9,10-DiHOME | Lipid | Fatty Acid, Dihydroxy | 1.50e-01 | 2.9e-01 |
| acetylcarnitine (C2) | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Short Chain) | 2.20e-01 | 4.0e-02 |
| aconitate [cis or trans] | Energy | TCA Cycle | -2.10e-01 | 2.5e-01 |
| adenine | Nucleotide | Purine Metabolism, Adenine containing | 9.00e-02 | 4.7e-01 |
| adenosine | Nucleotide | Purine Metabolism, Adenine containing | 1.00e-01 | 5.9e-01 |
| adenosine 5’-monophosphate (AMP) | Nucleotide | Purine Metabolism, Adenine containing | 3.30e-01 | 9.0e-02 |
| adrenate (22:4n6) | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 1.32e+00 | 0.0e+00 |
| alanine | Amino Acid | Alanine and Aspartate Metabolism | -3.40e-01 | 0.0e+00 |
| allantoic acid | Nucleotide | Purine Metabolism, (Hypo)Xanthine/Inosine containing | -5.40e-01 | 5.0e-02 |
| allantoin | Nucleotide | Purine Metabolism, (Hypo)Xanthine/Inosine containing | -3.70e-01 | 4.0e-02 |
| alpha-CEHC | Cofactors and Vitamins | Tocopherol Metabolism | -1.33e+00 | 0.0e+00 |
| alpha-CEHC sulfate | Cofactors and Vitamins | Tocopherol Metabolism | -5.00e-01 | 0.0e+00 |
| alpha-hydroxyisocaproate | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 4.30e-01 | 6.0e-02 |
| alpha-hydroxyisovalerate | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 4.20e-01 | 0.0e+00 |
| alpha-ketobutyrate | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | 1.14e+00 | 1.0e-02 |
| alpha-ketoglutaramate* | Amino Acid | Glutamate Metabolism | -9.00e-02 | 5.9e-01 |
| alpha-ketoglutarate | Energy | TCA Cycle | -8.70e-01 | 0.0e+00 |
| alpha-tocopherol | Cofactors and Vitamins | Tocopherol Metabolism | -3.30e-01 | 2.0e-01 |
| anserine | Amino Acid | Histidine Metabolism | -4.00e-01 | 7.9e-01 |
| anthranilate | Amino Acid | Tryptophan Metabolism | 7.40e-01 | 0.0e+00 |
| arabinose | Carbohydrate | Pentose Metabolism | -6.60e-01 | 6.3e-01 |
| arabitol/xylitol | Carbohydrate | Pentose Metabolism | -4.30e-01 | 1.0e-02 |
| arabonate/xylonate | Carbohydrate | Pentose Metabolism | -3.30e-01 | 6.0e-02 |
| arachidate (20:0) | Lipid | Long Chain Saturated Fatty Acid | 3.90e-01 | 1.0e-01 |
| arachidonate (20:4n6) | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 7.90e-01 | 2.0e-02 |
| arachidonoylcarnitine (C20:4) | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Polyunsaturated) | 3.20e-01 | 3.0e-02 |
| arachidonoylcholine | Lipid | Fatty Acid Metabolism (Acyl Choline) | -6.60e-01 | 3.0e-02 |
| arachidoylcarnitine (C20)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Long Chain Saturated) | 1.50e-01 | 8.0e-02 |
| arginine | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -8.00e-02 | 7.7e-01 |
| argininosuccinate | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -9.50e-01 | 0.0e+00 |
| ascorbic acid 2-sulfate | Cofactors and Vitamins | Ascorbate and Aldarate Metabolism | -2.50e-01 | 8.0e-02 |
| ascorbic acid 3-sulfate* | Cofactors and Vitamins | Ascorbate and Aldarate Metabolism | 1.00e-01 | 3.8e-01 |
| asparagine | Amino Acid | Alanine and Aspartate Metabolism | -2.00e-02 | 6.3e-01 |
| aspartate | Amino Acid | Alanine and Aspartate Metabolism | -1.10e-01 | 4.1e-01 |
| azelate (C9-DC) | Lipid | Fatty Acid, Dicarboxylate | -3.30e-01 | 6.0e-02 |
| behenoyl dihydrosphingomyelin (d18:0/22:0)* | Lipid | Dihydrosphingomyelins | 6.00e-01 | 0.0e+00 |
| behenoyl sphingomyelin (d18:1/22:0)* | Lipid | Sphingomyelins | 3.10e-01 | 1.0e-02 |
| behenoylcarnitine (C22)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Long Chain Saturated) | -2.30e-01 | 2.1e-01 |
| benzoate | Xenobiotics | Benzoate Metabolism | -1.70e-01 | 8.5e-01 |
| benzyl alcohol glucuronide | Xenobiotics | Food Component/Plant | 3.40e-01 | 1.9e-01 |
| beta-alanine | Nucleotide | Pyrimidine Metabolism, Uracil containing | -3.00e-02 | 8.8e-01 |
| beta-guanidinopropanoate | Xenobiotics | Food Component/Plant | -6.10e-01 | 4.1e-01 |
| beta-hydroxyisovalerate | Amino Acid | Leucine, Isoleucine and Valine Metabolism | -8.00e-02 | 7.0e-01 |
| beta-muricholate | Lipid | Primary Bile Acid Metabolism | -9.40e-01 | 1.0e-02 |
| beta-sitosterol | Lipid | Sterol | 4.40e-01 | 0.0e+00 |
| betaine | Amino Acid | Glycine, Serine and Threonine Metabolism | -1.00e-01 | 1.1e-01 |
| betonicine | Xenobiotics | Food Component/Plant | -5.70e-01 | 0.0e+00 |
| bilirubin (Z,Z) | Cofactors and Vitamins | Hemoglobin and Porphyrin Metabolism | -3.22e+00 | 1.0e-02 |
| biliverdin | Cofactors and Vitamins | Hemoglobin and Porphyrin Metabolism | -8.70e-01 | 1.6e-01 |
| biopterin | Cofactors and Vitamins | Tetrahydrobiopterin Metabolism | -3.10e-01 | 1.2e-01 |
| biotin | Cofactors and Vitamins | Biotin Metabolism | 1.42e+00 | 0.0e+00 |
| branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* | Partially Characterized Molecules | Partially Characterized Molecules | 1.00e-01 | 2.9e-01 |
| branched chain 14:0 dicarboxylic acid** | Lipid | Fatty Acid, Dicarboxylate | -6.80e-01 | 1.0e-02 |
| butyrate/isobutyrate (4:0) | Lipid | Short Chain Fatty Acid | -6.40e-01 | 1.8e-01 |
| butyrylcarnitine (C4) | Lipid | Fatty Acid Metabolism (also BCAA Metabolism) | -8.50e-01 | 1.0e-02 |
| butyrylglycine | Lipid | Fatty Acid Metabolism (also BCAA Metabolism) | 2.40e-01 | 3.4e-01 |
| C-glycosyltryptophan | Amino Acid | Tryptophan Metabolism | -4.20e-01 | 0.0e+00 |
| caffeic acid sulfate | Xenobiotics | Food Component/Plant | -1.32e+00 | 0.0e+00 |
| campesterol | Lipid | Sterol | 2.70e-01 | 6.0e-02 |
| caprate (10:0) | Lipid | Medium Chain Fatty Acid | 4.00e-02 | 6.3e-01 |
| caproate (6:0) | Lipid | Medium Chain Fatty Acid | -3.70e-01 | 1.0e-02 |
| caprylate (8:0) | Lipid | Medium Chain Fatty Acid | -2.10e-01 | 2.9e-01 |
| carboxyethyl-GABA | Amino Acid | Glutamate Metabolism | -9.60e-01 | 3.0e-02 |
| carnitine | Lipid | Carnitine Metabolism | -3.80e-01 | 0.0e+00 |
| carnosine | Amino Acid | Histidine Metabolism | -2.10e-01 | 8.3e-01 |
| catechol glucuronide | Amino Acid | Tyrosine Metabolism | -7.10e-01 | 7.0e-02 |
| catechol sulfate | Xenobiotics | Benzoate Metabolism | -4.30e-01 | 1.5e-01 |
| ceramide (d16:1/24:1, d18:1/22:1)* | Lipid | Ceramides | -5.50e-01 | 2.0e-01 |
| ceramide (d18:2/24:1, d18:1/24:2)* | Lipid | Ceramides | -1.60e-01 | 8.0e-02 |
| chenodeoxycholate | Lipid | Primary Bile Acid Metabolism | -1.09e+00 | 5.2e-01 |
| chenodeoxycholic acid sulfate (1) | Lipid | Primary Bile Acid Metabolism | -1.53e+00 | 0.0e+00 |
| chiro-inositol | Lipid | Inositol Metabolism | -7.60e-01 | 0.0e+00 |
| cholate | Lipid | Primary Bile Acid Metabolism | -7.40e-01 | 2.1e-01 |
| cholesterol | Lipid | Sterol | 2.90e-01 | 2.0e-02 |
| cholesterol sulfate | Lipid | Sterol | 1.00e-01 | 3.3e-01 |
| choline | Lipid | Phospholipid Metabolism | -5.00e-02 | 5.4e-01 |
| choline phosphate | Lipid | Phospholipid Metabolism | 1.20e-01 | 4.0e-01 |
| cinnamate | Xenobiotics | Food Component/Plant | -5.60e-01 | 5.4e-01 |
| cinnamoylglycine | Xenobiotics | Food Component/Plant | -1.50e-01 | 5.4e-01 |
| cis-3,4-methyleneheptanoylcarnitine | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Medium Chain) | -5.00e-02 | 9.3e-01 |
| cis-4-decenoate (10:1n6)* | Lipid | Medium Chain Fatty Acid | 3.00e-01 | 1.0e-01 |
| cis-4-decenoylcarnitine (C10:1) | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Monounsaturated) | -1.40e-01 | 7.6e-01 |
| cis-4-hydroxyproline | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -2.30e+00 | 0.0e+00 |
| citrate | Energy | TCA Cycle | 2.00e-02 | 7.9e-01 |
| citrulline | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -3.00e-02 | 7.9e-01 |
| corticosterone | Lipid | Corticosteroids | 6.60e-01 | 0.0e+00 |
| creatine | Amino Acid | Creatine Metabolism | 1.80e-01 | 4.0e-02 |
| creatine phosphate | Amino Acid | Creatine Metabolism | 4.70e-01 | 1.5e-01 |
| creatinine | Amino Acid | Creatine Metabolism | -2.90e-01 | 0.0e+00 |
| cystathionine | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | -5.60e-01 | 0.0e+00 |
| cysteine | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | -3.40e-01 | 1.1e-01 |
| cysteine-glutathione disulfide | Amino Acid | Glutathione Metabolism | -2.60e-01 | 2.9e-01 |
| cysteine s-sulfate | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | -2.00e-01 | 6.1e-01 |
| cysteine sulfinic acid | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | 2.30e-01 | 0.0e+00 |
| cysteinylglycine disulfide* | Amino Acid | Glutathione Metabolism | 5.00e-02 | 7.1e-01 |
| cystine | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | -1.90e-01 | 4.0e-02 |
| cytidine | Nucleotide | Pyrimidine Metabolism, Cytidine containing | 4.80e-01 | 0.0e+00 |
| cytosine | Nucleotide | Pyrimidine Metabolism, Cytidine containing | -9.80e-01 | 0.0e+00 |
| daidzein | Xenobiotics | Food Component/Plant | -1.36e+00 | 0.0e+00 |
| daidzein 7-O-glucuronide | Xenobiotics | Food Component/Plant | -1.36e+00 | 1.0e-02 |
| daidzein sulfate (1) | Xenobiotics | Food Component/Plant | -1.05e+00 | 1.0e-02 |
| daidzein sulfate (2) | Xenobiotics | Food Component/Plant | -1.52e+00 | 0.0e+00 |
| decadienedioic acid (C10:2-DC)** | Lipid | Fatty Acid, Dicarboxylate | 6.00e-01 | 1.0e-02 |
| decanoylcarnitine (C10) | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Medium Chain) | 1.70e-01 | 1.4e-01 |
| delta-CEHC sulfate | Cofactors and Vitamins | Tocopherol Metabolism | -9.30e-01 | 0.0e+00 |
| deoxycarnitine | Lipid | Carnitine Metabolism | -3.00e-01 | 1.0e-02 |
| diacylglycerol (16:1/18:2 [2], 16:0/18:3 [1])* | Lipid | Diacylglycerol | 2.20e-01 | 3.6e-01 |
| dihomo-linoleate (20:2n6) | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 1.04e+00 | 1.0e-02 |
| dihomo-linolenate (20:3n3 or n6) | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 9.90e-01 | 1.0e-02 |
| dihomo-linolenoylcarnitine (C20:3n3 or 6)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Polyunsaturated) | 3.60e-01 | 0.0e+00 |
| dihomo-linoleoylcarnitine (C20:2)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Polyunsaturated) | 4.70e-01 | 0.0e+00 |
| dihydroferulic acid sulfate | Xenobiotics | Food Component/Plant | -1.27e+00 | 1.1e-01 |
| dihydroorotate | Nucleotide | Pyrimidine Metabolism, Orotate containing | -5.50e-01 | 2.3e-01 |
| dimethyl sulfone | Xenobiotics | Chemical | -7.80e-01 | 1.0e-02 |
| dimethylarginine (SDMA + ADMA) | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -8.00e-02 | 3.1e-01 |
| dimethylglycine | Amino Acid | Glycine, Serine and Threonine Metabolism | 2.30e-01 | 0.0e+00 |
| dimethylmalonic acid | Lipid | Fatty Acid, Dicarboxylate | -3.00e-02 | 9.7e-01 |
| docosadienoate (22:2n6) | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 8.90e-01 | 1.0e-02 |
| docosadioate (C22-DC) | Lipid | Fatty Acid, Dicarboxylate | -3.70e-01 | 2.2e-01 |
| docosahexaenoate (DHA; 22:6n3) | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 1.28e+00 | 0.0e+00 |
| docosahexaenoylcarnitine (C22:6)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Polyunsaturated) | 2.70e-01 | 9.0e-02 |
| docosahexaenoylcholine | Lipid | Fatty Acid Metabolism (Acyl Choline) | -6.20e-01 | 8.0e-02 |
| docosapentaenoate (n3 DPA; 22:5n3) | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 1.24e+00 | 0.0e+00 |
| docosatrienoate (22:3n6)* | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 1.49e+00 | 1.0e-02 |
| dodecadienoate (12:2)* | Lipid | Fatty Acid, Dicarboxylate | 6.70e-01 | 1.0e-02 |
| dodecanedioate (C12-DC) | Lipid | Fatty Acid, Dicarboxylate | 5.00e-02 | 6.5e-01 |
| dodecenedioate (C12:1-DC)* | Lipid | Fatty Acid, Dicarboxylate | 3.80e-01 | 9.0e-02 |
| ectoine | Xenobiotics | Chemical | -1.01e+00 | 0.0e+00 |
| EDTA | Xenobiotics | Chemical | 1.60e-01 | 7.7e-01 |
| eicosanedioate (C20-DC) | Lipid | Fatty Acid, Dicarboxylate | 6.00e-02 | 6.0e-01 |
| eicosapentaenoate (EPA; 20:5n3) | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 1.29e+00 | 0.0e+00 |
| eicosenedioate (C20:1-DC)* | Lipid | Fatty Acid, Dicarboxylate | -1.10e-01 | 1.0e+00 |
| eicosenoate (20:1) | Lipid | Long Chain Monounsaturated Fatty Acid | 7.30e-01 | 2.0e-02 |
| eicosenoylcarnitine (C20:1)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Monounsaturated) | 4.10e-01 | 0.0e+00 |
| enterolactone sulfate | Xenobiotics | Food Component/Plant | -1.13e+00 | 0.0e+00 |
| equol glucuronide | Xenobiotics | Food Component/Plant | -9.60e-01 | 0.0e+00 |
| equol sulfate | Xenobiotics | Food Component/Plant | -3.40e-01 | 8.0e-02 |
| ergothioneine | Xenobiotics | Food Component/Plant | -4.10e-01 | 1.5e-01 |
| erucate (22:1n9) | Lipid | Long Chain Monounsaturated Fatty Acid | 1.60e-01 | 6.3e-01 |
| erythritol | Xenobiotics | Food Component/Plant | -3.90e-01 | 0.0e+00 |
| erythronate* | Carbohydrate | Aminosugar Metabolism | -3.40e-01 | 0.0e+00 |
| ethyl beta-glucopyranoside | Xenobiotics | Food Component/Plant | -7.90e-01 | 7.0e-02 |
| ethyl glucuronide | Xenobiotics | Chemical | -6.20e-01 | 5.0e-02 |
| ethylmalonate | Amino Acid | Leucine, Isoleucine and Valine Metabolism | -2.50e-01 | 5.0e-02 |
| ferulic acid 4-sulfate | Xenobiotics | Food Component/Plant | -1.33e+00 | 8.0e-02 |
| formiminoglutamate | Amino Acid | Histidine Metabolism | 5.00e-02 | 6.4e-01 |
| fructose | Carbohydrate | Fructose, Mannose and Galactose Metabolism | 2.70e-01 | 5.0e-02 |
| fructosyllysine | Amino Acid | Lysine Metabolism | -2.00e-02 | 9.1e-01 |
| fumarate | Energy | TCA Cycle | -3.70e-01 | 2.0e-02 |
| galactonate | Carbohydrate | Fructose, Mannose and Galactose Metabolism | 1.70e-01 | 2.6e-01 |
| gamma-CEHC | Cofactors and Vitamins | Tocopherol Metabolism | -1.97e+00 | 0.0e+00 |
| gamma-CEHC sulfate | Cofactors and Vitamins | Tocopherol Metabolism | -9.40e-01 | 0.0e+00 |
| gamma-glutamyl-2-aminobutyrate | Peptide | Gamma-glutamyl Amino Acid | 1.63e+00 | 0.0e+00 |
| gamma-glutamyl-alpha-lysine | Peptide | Gamma-glutamyl Amino Acid | -2.80e-01 | 1.4e-01 |
| gamma-glutamyl-epsilon-lysine | Peptide | Gamma-glutamyl Amino Acid | -3.50e-01 | 2.4e-01 |
| gamma-glutamylalanine | Peptide | Gamma-glutamyl Amino Acid | -7.90e-01 | 0.0e+00 |
| gamma-glutamylcitrulline* | Peptide | Gamma-glutamyl Amino Acid | -1.60e-01 | 6.7e-01 |
| gamma-glutamylglutamate | Peptide | Gamma-glutamyl Amino Acid | -8.10e-01 | 0.0e+00 |
| gamma-glutamylglutamine | Peptide | Gamma-glutamyl Amino Acid | -2.50e-01 | 5.0e-02 |
| gamma-glutamylglycine | Peptide | Gamma-glutamyl Amino Acid | -6.60e-01 | 0.0e+00 |
| gamma-glutamylhistidine | Peptide | Gamma-glutamyl Amino Acid | -1.10e-01 | 4.1e-01 |
| gamma-glutamylisoleucine* | Peptide | Gamma-glutamyl Amino Acid | 5.30e-01 | 0.0e+00 |
| gamma-glutamylleucine | Peptide | Gamma-glutamyl Amino Acid | 6.10e-01 | 0.0e+00 |
| gamma-glutamylmethionine | Peptide | Gamma-glutamyl Amino Acid | -3.70e-01 | 5.0e-01 |
| gamma-glutamylphenylalanine | Peptide | Gamma-glutamyl Amino Acid | 1.70e-01 | 7.0e-02 |
| gamma-glutamylserine | Peptide | Gamma-glutamyl Amino Acid | -5.20e-01 | 0.0e+00 |
| gamma-glutamylthreonine | Peptide | Gamma-glutamyl Amino Acid | -1.10e-01 | 2.1e-01 |
| gamma-glutamyltryptophan | Peptide | Gamma-glutamyl Amino Acid | -9.10e-01 | 0.0e+00 |
| gamma-glutamyltyrosine | Peptide | Gamma-glutamyl Amino Acid | -7.30e-01 | 0.0e+00 |
| gamma-glutamylvaline | Peptide | Gamma-glutamyl Amino Acid | 4.80e-01 | 0.0e+00 |
| gamma-tocopherol/beta-tocopherol | Cofactors and Vitamins | Tocopherol Metabolism | -1.40e-01 | 2.7e-01 |
| genistein | Xenobiotics | Food Component/Plant | -1.99e+00 | 2.0e-02 |
| genistein glucuronide* | Xenobiotics | Food Component/Plant | -1.19e+00 | 2.0e-02 |
| genistein sulfate* | Xenobiotics | Food Component/Plant | -1.48e+00 | 0.0e+00 |
| gentisate | Amino Acid | Tyrosine Metabolism | -1.10e+00 | 2.0e-02 |
| gluconate | Xenobiotics | Food Component/Plant | 1.60e-01 | 2.8e-01 |
| glucose | Carbohydrate | Glycolysis, Gluconeogenesis, and Pyruvate Metabolism | 3.40e-01 | 0.0e+00 |
| glucuronate | Carbohydrate | Aminosugar Metabolism | 1.10e-01 | 3.9e-01 |
| glutamate | Amino Acid | Glutamate Metabolism | -4.50e-01 | 0.0e+00 |
| glutamine | Amino Acid | Glutamate Metabolism | -9.00e-02 | 2.2e-01 |
| glutamine_degradant* | Partially Characterized Molecules | Partially Characterized Molecules | -8.10e-01 | 1.0e-02 |
| glutarate (C5-DC) | Lipid | Fatty Acid, Dicarboxylate | 4.90e-01 | 5.0e-02 |
| glutathione, oxidized (GSSG) | Amino Acid | Glutathione Metabolism | 0.00e+00 | 7.6e-01 |
| glycerate | Carbohydrate | Glycolysis, Gluconeogenesis, and Pyruvate Metabolism | 2.50e-01 | 1.1e-01 |
| glycerol | Lipid | Glycerolipid Metabolism | 4.30e-01 | 6.0e-02 |
| glycerol 3-phosphate | Lipid | Glycerolipid Metabolism | -1.20e-01 | 8.7e-01 |
| glycerophosphoethanolamine | Lipid | Phospholipid Metabolism | -3.00e-02 | 9.0e-01 |
| glycerophosphoglycerol | Lipid | Glycerolipid Metabolism | 3.20e-01 | 1.5e-01 |
| glycerophosphoinositol* | Lipid | Phospholipid Metabolism | -1.80e-01 | 9.1e-01 |
| glycerophosphorylcholine (GPC) | Lipid | Phospholipid Metabolism | -2.60e-01 | 1.0e-02 |
| glycerophosphoserine* | Lipid | Phospholipid Metabolism | 3.30e-01 | 9.0e-02 |
| glycine | Amino Acid | Glycine, Serine and Threonine Metabolism | -3.40e-01 | 0.0e+00 |
| glycitein sulfate (2) | Xenobiotics | Food Component/Plant | -1.71e+00 | 0.0e+00 |
| glyco-alpha-muricholate** | Lipid | Primary Bile Acid Metabolism | -4.80e-01 | 8.9e-01 |
| glycochenodeoxycholate | Lipid | Primary Bile Acid Metabolism | -7.20e-01 | 7.7e-01 |
| glycocholate | Lipid | Primary Bile Acid Metabolism | -2.50e-01 | 8.4e-01 |
| glycodeoxycholate | Lipid | Secondary Bile Acid Metabolism | -1.33e+00 | 7.1e-01 |
| glycohyodeoxycholate | Lipid | Secondary Bile Acid Metabolism | -1.25e+00 | 4.8e-01 |
| glycosyl-N-nervonoyl-sphingosine (d18:1/24:1)* | Lipid | Hexosylceramides (HCER) | 7.80e-01 | 1.0e-02 |
| glycosyl-N-palmitoyl-sphingosine (d18:1/16:0) | Lipid | Hexosylceramides (HCER) | 3.60e-01 | 0.0e+00 |
| glycylvaline | Peptide | Dipeptide | 1.10e-01 | 5.9e-01 |
| guaiacol sulfate | Xenobiotics | Benzoate Metabolism | -6.40e-01 | 1.0e-02 |
| guanidinoacetate | Amino Acid | Creatine Metabolism | -9.50e-01 | 0.0e+00 |
| gulonate* | Cofactors and Vitamins | Ascorbate and Aldarate Metabolism | -1.40e-01 | 2.0e-02 |
| heme | Cofactors and Vitamins | Hemoglobin and Porphyrin Metabolism | 5.00e-01 | 1.9e-01 |
| heneicosapentaenoate (21:5n3) | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 1.45e+00 | 0.0e+00 |
| heptadecatrienoate (17:3)* | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 1.35e+00 | 0.0e+00 |
| heptenedioate (C7:1-DC)* | Lipid | Fatty Acid, Dicarboxylate | -2.80e-01 | 6.1e-01 |
| hexadecadienoate (16:2n6) | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 1.00e+00 | 0.0e+00 |
| hexadecanedioate (C16-DC) | Lipid | Fatty Acid, Dicarboxylate | 7.60e-01 | 0.0e+00 |
| hexadecatrienoate (16:3n3) | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 1.10e+00 | 0.0e+00 |
| hexadecenedioate (C16:1-DC)* | Lipid | Fatty Acid, Dicarboxylate | -1.90e-01 | 5.2e-01 |
| hexanoylcarnitine (C6) | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Medium Chain) | -2.60e-01 | 6.5e-01 |
| hexanoylglycine | Lipid | Fatty Acid Metabolism (Acyl Glycine) | 6.30e-01 | 4.0e-02 |
| hippurate | Xenobiotics | Benzoate Metabolism | 1.80e-01 | 2.5e-01 |
| histamine | Amino Acid | Histidine Metabolism | -2.20e-01 | 3.0e-02 |
| histidine | Amino Acid | Histidine Metabolism | 1.50e-01 | 2.0e-02 |
| histidine betaine (hercynine)* | Xenobiotics | Food Component/Plant | -3.60e-01 | 8.7e-01 |
| homoarginine | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -6.00e-02 | 7.6e-01 |
| homocitrulline | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -3.10e-01 | 4.0e-02 |
| homostachydrine* | Xenobiotics | Food Component/Plant | -8.00e-02 | 4.9e-01 |
| hydantoin-5-propionate | Amino Acid | Histidine Metabolism | 8.60e-01 | 1.0e-02 |
| hydroquinone sulfate | Xenobiotics | Drug - Topical Agents | -8.10e-01 | 4.0e-02 |
| hydroxyasparagine** | Amino Acid | Alanine and Aspartate Metabolism | -3.30e-01 | 0.0e+00 |
| hydroxypalmitoyl sphingomyelin (d18:1/16:0(OH))** | Lipid | Sphingomyelins | -3.40e-01 | 3.0e-02 |
| hyocholate | Lipid | Secondary Bile Acid Metabolism | -6.80e-01 | 3.6e-01 |
| hyodeoxycholate | Lipid | Secondary Bile Acid Metabolism | -1.45e+00 | 1.0e-02 |
| hypotaurine | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | 1.90e-01 | 2.3e-01 |
| hypoxanthine | Nucleotide | Purine Metabolism, (Hypo)Xanthine/Inosine containing | -3.08e+00 | 7.0e-02 |
| imidazole lactate | Amino Acid | Histidine Metabolism | -2.10e-01 | 5.6e-01 |
| imidazole propionate | Amino Acid | Histidine Metabolism | -5.60e-01 | 3.0e-02 |
| iminodiacetate (IDA) | Xenobiotics | Chemical | -1.10e-01 | 4.0e-01 |
| indole-3-carboxylate | Amino Acid | Tryptophan Metabolism | 1.80e-01 | 7.0e-02 |
| indoleacetate | Amino Acid | Tryptophan Metabolism | -4.80e-01 | 0.0e+00 |
| indoleacetylglycine | Amino Acid | Tryptophan Metabolism | -5.00e-01 | 0.0e+00 |
| indoleacrylate | Amino Acid | Tryptophan Metabolism | -5.40e-01 | 0.0e+00 |
| indolelactate | Amino Acid | Tryptophan Metabolism | -6.80e-01 | 0.0e+00 |
| indolepropionate | Amino Acid | Tryptophan Metabolism | -2.00e-01 | 1.3e-01 |
| indolin-2-one | Xenobiotics | Food Component/Plant | -6.20e-01 | 4.0e-02 |
| inosine | Nucleotide | Purine Metabolism, (Hypo)Xanthine/Inosine containing | -3.26e+00 | 2.0e-02 |
| isobutyrylcarnitine (C4) | Amino Acid | Leucine, Isoleucine and Valine Metabolism | -4.30e-01 | 7.0e-02 |
| isocitrate | Energy | TCA Cycle | -1.60e-01 | 1.6e-01 |
| isocitric lactone | Energy | TCA Cycle | -6.00e-02 | 6.4e-01 |
| isohyodeoxycholate | Lipid | Secondary Bile Acid Metabolism | -1.89e+00 | 0.0e+00 |
| isoleucine | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 5.90e-01 | 0.0e+00 |
| isoleucylglycine | Peptide | Dipeptide | -2.90e-01 | 4.6e-01 |
| isoleucylhydroxyproline* | Peptide | Dipeptide Derivative | -5.70e-01 | 0.0e+00 |
| isovalerate (i5:0) | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 2.50e-01 | 3.5e-01 |
| isovalerylcarnitine (C5) | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 5.80e-01 | 1.0e-02 |
| isovalerylglycine | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 8.70e-01 | 0.0e+00 |
| jasmonic acid | Xenobiotics | Food Component/Plant | -9.00e-01 | 0.0e+00 |
| kynurenate | Amino Acid | Tryptophan Metabolism | 6.80e-01 | 1.0e-02 |
| kynurenine | Amino Acid | Tryptophan Metabolism | 3.00e-01 | 1.0e-02 |
| lactate | Carbohydrate | Glycolysis, Gluconeogenesis, and Pyruvate Metabolism | -1.30e-01 | 3.1e-01 |
| laurate (12:0) | Lipid | Medium Chain Fatty Acid | 2.90e-01 | 3.0e-02 |
| laurylcarnitine (C12) | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Medium Chain) | 2.80e-01 | 1.0e-02 |
| leucine | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 6.50e-01 | 0.0e+00 |
| leucylhydroxyproline* | Peptide | Dipeptide Derivative | -3.10e-01 | 0.0e+00 |
| lignoceroyl sphingomyelin (d18:1/24:0) | Lipid | Sphingomyelins | 3.00e-01 | 0.0e+00 |
| lignoceroylcarnitine (C24)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Long Chain Saturated) | 2.00e-01 | 3.0e-02 |
| linoleate (18:2n6) | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 1.01e+00 | 1.0e-02 |
| linolenate [alpha or gamma; (18:3n3 or 6)] | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 1.05e+00 | 1.0e-02 |
| linolenoylcarnitine (C18:3)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Polyunsaturated) | 3.40e-01 | 7.0e-02 |
| linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]* | Lipid | Diacylglycerol | 1.27e+00 | 0.0e+00 |
| linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]* | Lipid | Diacylglycerol | 1.24e+00 | 0.0e+00 |
| linoleoyl-docosahexaenoyl-glycerol (18:2/22:6) [1]* | Lipid | Diacylglycerol | 4.10e-01 | 8.0e-02 |
| linoleoyl-docosahexaenoyl-glycerol (18:2/22:6) [2]* | Lipid | Diacylglycerol | 1.04e+00 | 0.0e+00 |
| linoleoyl-linolenoyl-glycerol (18:2/18:3) [1]* | Lipid | Diacylglycerol | 6.00e-02 | 7.9e-01 |
| linoleoyl-linolenoyl-glycerol (18:2/18:3) [2]* | Lipid | Diacylglycerol | 8.10e-01 | 0.0e+00 |
| linoleoyl-linoleoyl-glycerol (18:2/18:2) [1]* | Lipid | Diacylglycerol | 4.10e-01 | 6.0e-02 |
| linoleoyl-linoleoyl-glycerol (18:2/18:2) [2]* | Lipid | Diacylglycerol | 4.90e-01 | 2.0e-02 |
| linoleoyl ethanolamide | Lipid | Endocannabinoid | 8.40e-01 | 2.0e-02 |
| linoleoylcarnitine (C18:2)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Polyunsaturated) | 4.60e-01 | 0.0e+00 |
| linoleoylcholine* | Lipid | Fatty Acid Metabolism (Acyl Choline) | -1.02e+00 | 1.0e-02 |
| lithocholate | Lipid | Secondary Bile Acid Metabolism | -1.12e+00 | 7.0e-02 |
| lysine | Amino Acid | Lysine Metabolism | 0.00e+00 | 8.8e-01 |
| lyxonate | Carbohydrate | Pentose Metabolism | 3.00e-02 | 6.7e-01 |
| malate | Energy | TCA Cycle | -2.50e-01 | 8.0e-02 |
| maleate | Lipid | Fatty Acid, Dicarboxylate | 1.80e-01 | 2.4e-01 |
| maleoylcarnitine | Xenobiotics | Drug - Other | 1.00e-02 | 7.9e-01 |
| malonate | Lipid | Fatty Acid Synthesis | 5.00e-02 | 7.2e-01 |
| malonylcarnitine | Lipid | Fatty Acid Synthesis | 5.30e-01 | 1.5e-01 |
| maltose | Carbohydrate | Glycogen Metabolism | 1.30e+00 | 0.0e+00 |
| mannitol/sorbitol | Carbohydrate | Fructose, Mannose and Galactose Metabolism | -3.20e-01 | 3.4e-01 |
| mannonate* | Xenobiotics | Food Component/Plant | -1.10e-01 | 4.9e-01 |
| mannose | Carbohydrate | Fructose, Mannose and Galactose Metabolism | 4.00e-01 | 0.0e+00 |
| margarate (17:0) | Lipid | Long Chain Saturated Fatty Acid | 7.20e-01 | 3.0e-02 |
| margaroylcarnitine (C17)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Long Chain Saturated) | 5.10e-01 | 0.0e+00 |
| methionine | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | -2.50e-01 | 0.0e+00 |
| methionine sulfone | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | 1.50e-01 | 1.0e-01 |
| methionine sulfoxide | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | 4.00e-02 | 9.0e-01 |
| methyl-4-hydroxybenzoate sulfate | Xenobiotics | Benzoate Metabolism | 3.70e-01 | 1.5e-01 |
| methyl glucopyranoside (alpha + beta) | Xenobiotics | Food Component/Plant | -7.90e-01 | 0.0e+00 |
| methylphosphate | Nucleotide | Purine and Pyrimidine Metabolism | 1.00e-02 | 7.6e-01 |
| methylsuccinate | Amino Acid | Leucine, Isoleucine and Valine Metabolism | -5.90e-01 | 0.0e+00 |
| mevalonate | Lipid | Mevalonate Metabolism | -2.60e-01 | 2.0e-02 |
| mevalonolactone | Lipid | Mevalonate Metabolism | 2.70e-01 | 2.7e-01 |
| myo-inositol | Lipid | Inositol Metabolism | -7.00e-02 | 7.0e-01 |
| myristate (14:0) | Lipid | Long Chain Saturated Fatty Acid | 6.70e-01 | 2.0e-02 |
| myristoleate (14:1n5) | Lipid | Long Chain Monounsaturated Fatty Acid | 4.30e-01 | 2.0e-02 |
| myristoleoylcarnitine (C14:1)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Monounsaturated) | 1.50e-01 | 1.5e-01 |
| myristoylcarnitine (C14) | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Long Chain Saturated) | 5.80e-01 | 0.0e+00 |
| N-acetyl-1-methylhistidine* | Amino Acid | Histidine Metabolism | 1.00e-02 | 7.9e-01 |
| N-acetyl-2-aminooctanoate* | Lipid | Fatty Acid, Amino | 6.40e-01 | 0.0e+00 |
| N-acetyl-3-methylhistidine* | Amino Acid | Histidine Metabolism | 3.20e-01 | 3.0e-02 |
| N-acetyl-aspartyl-glutamate (NAAG) | Amino Acid | Glutamate Metabolism | -5.70e-01 | 1.0e-02 |
| N-acetyl-beta-alanine | Nucleotide | Pyrimidine Metabolism, Uracil containing | 3.70e-01 | 2.0e-02 |
| N-acetyl-isoputreanine | Amino Acid | Polyamine Metabolism | -9.20e-01 | 0.0e+00 |
| N-acetylalanine | Amino Acid | Alanine and Aspartate Metabolism | 1.20e-01 | 3.0e-01 |
| N-acetylarginine | Amino Acid | Urea cycle; Arginine and Proline Metabolism | 6.00e-02 | 5.2e-01 |
| N-acetylasparagine | Amino Acid | Alanine and Aspartate Metabolism | 7.20e-01 | 0.0e+00 |
| N-acetylaspartate (NAA) | Amino Acid | Alanine and Aspartate Metabolism | -2.90e-01 | 4.0e-02 |
| N-acetylcarnosine | Amino Acid | Histidine Metabolism | -7.50e-01 | 3.4e-01 |
| N-acetylcitrulline | Amino Acid | Urea cycle; Arginine and Proline Metabolism | 2.60e-01 | 3.0e-02 |
| N-acetylglucosamine/N-acetylgalactosamine | Carbohydrate | Aminosugar Metabolism | -9.00e-02 | 2.4e-01 |
| N-acetylglutamate | Amino Acid | Glutamate Metabolism | 1.90e-01 | 1.9e-01 |
| N-acetylglutamine | Amino Acid | Glutamate Metabolism | 3.70e-01 | 0.0e+00 |
| N-acetylglycine | Amino Acid | Glycine, Serine and Threonine Metabolism | 4.50e-01 | 0.0e+00 |
| N-acetylhistamine | Amino Acid | Histidine Metabolism | 1.20e-01 | 4.3e-01 |
| N-acetylhistidine | Amino Acid | Histidine Metabolism | 4.40e-01 | 0.0e+00 |
| N-acetylhomocitrulline | Amino Acid | Urea cycle; Arginine and Proline Metabolism | 7.20e-01 | 0.0e+00 |
| N-acetylisoleucine | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 3.04e+00 | 0.0e+00 |
| N-acetylkynurenine (2) | Amino Acid | Tryptophan Metabolism | -4.00e-02 | 8.5e-01 |
| N-acetylleucine | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 2.58e+00 | 0.0e+00 |
| N-acetylmethionine | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | 3.00e-01 | 5.0e-02 |
| N-acetylmethionine sulfoxide | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | 1.20e-01 | 7.4e-01 |
| N-acetylneuraminate | Carbohydrate | Aminosugar Metabolism | 1.10e-01 | 2.0e-01 |
| N-acetylphenylalanine | Amino Acid | Phenylalanine Metabolism | 1.60e+00 | 0.0e+00 |
| N-acetylproline | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -1.70e-01 | 3.1e-01 |
| N-acetylputrescine | Amino Acid | Polyamine Metabolism | 1.80e-01 | 3.8e-01 |
| N-acetylpyrraline | Xenobiotics | Food Component/Plant | -1.38e+00 | 0.0e+00 |
| N-acetylserine | Amino Acid | Glycine, Serine and Threonine Metabolism | 1.50e-01 | 0.0e+00 |
| N-acetyltaurine | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | 1.30e-01 | 4.5e-01 |
| N-acetylthreonine | Amino Acid | Glycine, Serine and Threonine Metabolism | -1.80e-01 | 2.4e-01 |
| N-acetyltryptophan | Amino Acid | Tryptophan Metabolism | -4.30e-01 | 1.0e-02 |
| N-acetyltyrosine | Amino Acid | Tyrosine Metabolism | 5.90e-01 | 1.0e-02 |
| N-acetylvaline | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 1.76e+00 | 0.0e+00 |
| N-behenoyl-sphingadienine (d18:2/22:0)* | Lipid | Ceramides | -6.60e-01 | 0.0e+00 |
| N-carbamoylalanine | Amino Acid | Alanine and Aspartate Metabolism | -6.40e-01 | 1.0e-02 |
| N-carbamoylaspartate | Nucleotide | Pyrimidine Metabolism, Orotate containing | 4.20e-01 | 1.0e-02 |
| N-delta-acetylornithine | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -1.30e-01 | 3.0e-02 |
| N-formylkynurenine | Amino Acid | Tryptophan Metabolism | -1.90e-01 | 3.7e-01 |
| N-formylmethionine | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | 5.70e-01 | 0.0e+00 |
| N-glycolylneuraminate | Carbohydrate | Aminosugar Metabolism | 3.00e-02 | 7.6e-01 |
| N-linoleoyltaurine* | Lipid | Endocannabinoid | 6.30e-01 | 1.0e-02 |
| N-methyl-GABA | Amino Acid | Glutamate Metabolism | -2.90e-01 | 1.1e-01 |
| N-methylalanine | Amino Acid | Alanine and Aspartate Metabolism | -2.30e-01 | 5.5e-01 |
| N-methylproline | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -2.10e-01 | 1.0e-02 |
| N-oleoyltaurine | Lipid | Endocannabinoid | 3.50e-01 | 1.4e-01 |
| N-palmitoyl-sphinganine (d18:0/16:0) | Lipid | Dihydroceramides | 1.70e-01 | 2.4e-01 |
| N-palmitoyl-sphingosine (d18:1/16:0) | Lipid | Ceramides | -1.70e-01 | 2.0e-02 |
| N-palmitoylglycine | Lipid | Fatty Acid Metabolism (Acyl Glycine) | -1.00e-02 | 7.3e-01 |
| N-palmitoyltaurine | Lipid | Endocannabinoid | 8.40e-01 | 2.0e-02 |
| N-stearoyl-sphingosine (d18:1/18:0)* | Lipid | Ceramides | 1.10e-01 | 5.1e-01 |
| N-stearoyltaurine | Lipid | Endocannabinoid | 6.40e-01 | 4.0e-02 |
| N,N-dimethylalanine | Amino Acid | Alanine and Aspartate Metabolism | -1.70e-01 | 2.6e-01 |
| N,N,N-trimethyl-5-aminovalerate | Amino Acid | Lysine Metabolism | 1.40e-01 | 2.7e-01 |
| N,N,N-trimethyl-alanylproline betaine (TMAP) | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -4.60e-01 | 3.0e-02 |
| N1-methyl-2-pyridone-5-carboxamide | Cofactors and Vitamins | Nicotinate and Nicotinamide Metabolism | 8.10e-01 | 0.0e+00 |
| N1-methyladenosine | Nucleotide | Purine Metabolism, Adenine containing | 1.20e-01 | 3.0e-01 |
| N1-methylinosine | Nucleotide | Purine Metabolism, (Hypo)Xanthine/Inosine containing | -1.80e-01 | 3.9e-01 |
| N2-acetyl,N6,N6-dimethyllysine | Amino Acid | Lysine Metabolism | 2.80e-01 | 9.0e-02 |
| N2-acetyllysine | Amino Acid | Lysine Metabolism | -1.00e-01 | 5.8e-01 |
| N2,N2-dimethylguanosine | Nucleotide | Purine Metabolism, Guanine containing | -3.00e-02 | 9.6e-01 |
| N2,N5-diacetylornithine | Amino Acid | Urea cycle; Arginine and Proline Metabolism | 3.40e-01 | 1.0e-02 |
| N4-acetylcytidine | Nucleotide | Pyrimidine Metabolism, Cytidine containing | -1.33e+00 | 0.0e+00 |
| N6-acetyllysine | Amino Acid | Lysine Metabolism | -2.80e-01 | 1.0e-02 |
| N6-carbamoylthreonyladenosine | Nucleotide | Purine Metabolism, Adenine containing | -2.50e-01 | 0.0e+00 |
| N6-methyllysine | Amino Acid | Lysine Metabolism | -4.00e-02 | 8.7e-01 |
| N6-succinyladenosine | Nucleotide | Purine Metabolism, Adenine containing | -6.00e-02 | 8.4e-01 |
| N6,N6-dimethyllysine | Amino Acid | Lysine Metabolism | 3.20e-01 | 0.0e+00 |
| N6,N6,N6-trimethyllysine | Amino Acid | Lysine Metabolism | -1.90e-01 | 8.0e-02 |
| nervonoylcarnitine (C24:1)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Monounsaturated) | -7.20e-01 | 1.0e-02 |
| nicotinamide | Cofactors and Vitamins | Nicotinate and Nicotinamide Metabolism | 8.80e-01 | 0.0e+00 |
| nicotinamide N-oxide | Cofactors and Vitamins | Nicotinate and Nicotinamide Metabolism | 6.70e-01 | 0.0e+00 |
| nicotinamide riboside | Cofactors and Vitamins | Nicotinate and Nicotinamide Metabolism | 5.20e-01 | 3.0e-02 |
| nicotinate ribonucleoside | Cofactors and Vitamins | Nicotinate and Nicotinamide Metabolism | 2.00e-01 | 3.5e-01 |
| nisinate (24:6n3) | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 1.20e+00 | 1.0e-02 |
| nonadecanedioate (C19-DC) | Lipid | Fatty Acid, Dicarboxylate | 8.70e-01 | 1.0e-02 |
| nonadecanoate (19:0) | Lipid | Long Chain Saturated Fatty Acid | 5.70e-01 | 2.0e-02 |
| O-sulfo-tyrosine | Xenobiotics | Chemical | -5.70e-01 | 0.0e+00 |
| octadecadienedioate (C18:2-DC)* | Lipid | Fatty Acid, Dicarboxylate | 4.80e-01 | 2.0e-02 |
| octadecanedioate (C18-DC) | Lipid | Fatty Acid, Dicarboxylate | 1.28e+00 | 0.0e+00 |
| octadecanedioylcarnitine (C18-DC)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Dicarboxylate) | 5.90e-01 | 0.0e+00 |
| octadecenedioate (C18:1-DC) | Lipid | Fatty Acid, Dicarboxylate | -8.00e-02 | 8.0e-01 |
| octadecenedioylcarnitine (C18:1-DC)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Dicarboxylate) | 6.60e-01 | 2.0e-02 |
| octanoylcarnitine (C8) | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Medium Chain) | 1.10e-01 | 4.2e-01 |
| oleate/vaccenate (18:1) | Lipid | Long Chain Monounsaturated Fatty Acid | 9.80e-01 | 1.0e-02 |
| oleoyl-arachidonoyl-glycerol (18:1/20:4) [1]* | Lipid | Diacylglycerol | 1.13e+00 | 0.0e+00 |
| oleoyl-arachidonoyl-glycerol (18:1/20:4) [2]* | Lipid | Diacylglycerol | 1.31e+00 | 0.0e+00 |
| oleoyl-linoleoyl-glycerol (18:1/18:2) [1] | Lipid | Diacylglycerol | 4.80e-01 | 3.0e-02 |
| oleoyl-linoleoyl-glycerol (18:1/18:2) [2] | Lipid | Diacylglycerol | 3.70e-01 | 1.2e-01 |
| oleoyl-oleoyl-glycerol (18:1/18:1) [1]* | Lipid | Diacylglycerol | 1.09e+00 | 1.0e-02 |
| oleoyl-oleoyl-glycerol (18:1/18:1) [2]* | Lipid | Diacylglycerol | -1.20e-01 | 9.9e-01 |
| oleoyl ethanolamide | Lipid | Endocannabinoid | 9.20e-01 | 0.0e+00 |
| oleoylcarnitine (C18:1) | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Monounsaturated) | 5.30e-01 | 0.0e+00 |
| oleoylcholine | Lipid | Fatty Acid Metabolism (Acyl Choline) | -7.50e-01 | 3.0e-02 |
| ophthalmate | Amino Acid | Glutathione Metabolism | 1.60e-01 | 3.8e-01 |
| ornithine | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -2.10e-01 | 8.1e-01 |
| orotate | Nucleotide | Pyrimidine Metabolism, Orotate containing | 8.00e-02 | 4.0e-01 |
| orotidine | Nucleotide | Pyrimidine Metabolism, Orotate containing | 2.90e-01 | 3.0e-02 |
| oxalate (ethanedioate) | Cofactors and Vitamins | Ascorbate and Aldarate Metabolism | 8.00e-02 | 2.8e-01 |
| p-cresol glucuronide* | Amino Acid | Tyrosine Metabolism | -7.90e-01 | 1.0e-02 |
| p-cresol sulfate | Xenobiotics | Benzoate Metabolism | -4.30e-01 | 2.2e-01 |
| palmitate (16:0) | Lipid | Long Chain Saturated Fatty Acid | 8.70e-01 | 1.0e-02 |
| palmitoleate (16:1n7) | Lipid | Long Chain Monounsaturated Fatty Acid | 8.40e-01 | 1.0e-02 |
| palmitoleoyl-arachidonoyl-glycerol (16:1/20:4) [2]* | Lipid | Diacylglycerol | 1.15e+00 | 0.0e+00 |
| palmitoleoyl-linoleoyl-glycerol (16:1/18:2) [1]* | Lipid | Diacylglycerol | 4.30e-01 | 1.2e-01 |
| palmitoleoylcarnitine (C16:1)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Monounsaturated) | 5.00e-01 | 0.0e+00 |
| palmitoyl-arachidonoyl-glycerol (16:0/20:4) [1]* | Lipid | Diacylglycerol | 7.30e-01 | 1.0e-02 |
| palmitoyl-arachidonoyl-glycerol (16:0/20:4) [2]* | Lipid | Diacylglycerol | 1.01e+00 | 0.0e+00 |
| palmitoyl-docosahexaenoyl-glycerol (16:0/22:6) [1]* | Lipid | Diacylglycerol | 4.50e-01 | 9.0e-02 |
| palmitoyl-docosahexaenoyl-glycerol (16:0/22:6) [2]* | Lipid | Diacylglycerol | 1.52e+00 | 0.0e+00 |
| palmitoyl-linolenoyl-glycerol (16:0/18:3) [2]* | Lipid | Diacylglycerol | 4.30e-01 | 2.3e-01 |
| palmitoyl-linoleoyl-glycerol (16:0/18:2) [1]* | Lipid | Diacylglycerol | 6.70e-01 | 0.0e+00 |
| palmitoyl-linoleoyl-glycerol (16:0/18:2) [2]* | Lipid | Diacylglycerol | 6.00e-01 | 1.0e-02 |
| palmitoyl-oleoyl-glycerol (16:0/18:1) [1]* | Lipid | Diacylglycerol | 6.40e-01 | 2.0e-02 |
| palmitoyl-oleoyl-glycerol (16:0/18:1) [2]* | Lipid | Diacylglycerol | 6.00e-01 | 1.0e-02 |
| palmitoyl-sphingosine-phosphoethanolamine (d18:1/16:0) | Lipid | Ceramide PEs | -5.00e-02 | 9.8e-01 |
| palmitoyl dihydrosphingomyelin (d18:0/16:0)* | Lipid | Dihydrosphingomyelins | 3.80e-01 | 1.0e-02 |
| palmitoyl ethanolamide | Lipid | Endocannabinoid | 1.04e+00 | 0.0e+00 |
| palmitoyl sphingomyelin (d18:1/16:0) | Lipid | Sphingomyelins | 1.50e-01 | 6.0e-02 |
| palmitoylcarnitine (C16) | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Long Chain Saturated) | 7.90e-01 | 0.0e+00 |
| palmitoylcholine | Lipid | Fatty Acid Metabolism (Acyl Choline) | -7.40e-01 | 2.0e-02 |
| pantothenate | Cofactors and Vitamins | Pantothenate and CoA Metabolism | -2.10e-01 | 0.0e+00 |
| pelargonate (9:0) | Lipid | Medium Chain Fatty Acid | 3.00e-02 | 7.2e-01 |
| pentadecanoate (15:0) | Lipid | Long Chain Saturated Fatty Acid | 8.10e-01 | 4.0e-02 |
| pentadecanoylcarnitine (C15)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Long Chain Saturated) | 5.10e-01 | 0.0e+00 |
| pentobarbital | Xenobiotics | Drug - Neurological | 1.60e-01 | 3.9e-01 |
| pentose acid* | Partially Characterized Molecules | Partially Characterized Molecules | -6.00e-01 | 4.0e-02 |
| perfluorooctanesulfonate (PFOS) | Xenobiotics | Chemical | -1.40e-01 | 1.1e-01 |
| phenol glucuronide | Amino Acid | Tyrosine Metabolism | -1.60e-01 | 8.3e-01 |
| phenol sulfate | Amino Acid | Tyrosine Metabolism | -1.80e-01 | 5.1e-01 |
| phenylacetylglycine | Peptide | Acetylated Peptides | -1.80e-01 | 4.5e-01 |
| phenylalanine | Amino Acid | Phenylalanine Metabolism | 2.00e-01 | 0.0e+00 |
| phenylalanylhydroxyproline* | Peptide | Dipeptide | -1.35e+00 | 2.0e-02 |
| phenyllactate (PLA) | Amino Acid | Phenylalanine Metabolism | -1.42e+00 | 1.0e-02 |
| phenylpropionylglycine | Xenobiotics | Benzoate Metabolism | 1.40e-01 | 4.1e-01 |
| phenylpyruvate | Amino Acid | Phenylalanine Metabolism | 5.20e-01 | 0.0e+00 |
| phosphate | Energy | Oxidative Phosphorylation | 4.00e-01 | 5.0e-02 |
| phosphatidylcholine (18:0/20:2, 20:0/18:2)* | Lipid | Phosphatidylcholine (PC) | 2.10e-01 | 1.4e-01 |
| phosphoethanolamine | Lipid | Phospholipid Metabolism | 5.00e-01 | 1.0e-02 |
| picolinate | Amino Acid | Tryptophan Metabolism | 1.19e+00 | 0.0e+00 |
| pimelate (C7-DC) | Lipid | Fatty Acid, Dicarboxylate | 4.90e-01 | 9.0e-02 |
| pinitol | Lipid | Inositol Metabolism | -1.04e+00 | 1.0e-02 |
| pipecolate | Amino Acid | Lysine Metabolism | -3.20e-01 | 0.0e+00 |
| pro-hydroxy-pro | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -4.30e-01 | 0.0e+00 |
| proline | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -3.70e-01 | 0.0e+00 |
| prolylglycine | Peptide | Dipeptide | 1.00e-01 | 4.4e-01 |
| propionylcarnitine (C3) | Lipid | Fatty Acid Metabolism (also BCAA Metabolism) | -2.40e-01 | 1.4e-01 |
| propionylglycine | Lipid | Fatty Acid Metabolism (also BCAA Metabolism) | 3.10e-01 | 2.5e-01 |
| protoporphyrin IX | Cofactors and Vitamins | Hemoglobin and Porphyrin Metabolism | -1.80e-01 | 3.9e-01 |
| pseudouridine | Nucleotide | Pyrimidine Metabolism, Uracil containing | -2.00e-01 | 0.0e+00 |
| putrescine | Amino Acid | Polyamine Metabolism | -8.00e-02 | 4.9e-01 |
| pyridoxal | Cofactors and Vitamins | Vitamin B6 Metabolism | -2.20e-01 | 9.4e-01 |
| pyridoxamine | Cofactors and Vitamins | Vitamin B6 Metabolism | 8.50e-01 | 1.0e-02 |
| pyridoxate | Cofactors and Vitamins | Vitamin B6 Metabolism | -7.00e-02 | 5.0e-01 |
| pyrraline | Xenobiotics | Food Component/Plant | -1.18e+00 | 0.0e+00 |
| pyruvate | Carbohydrate | Glycolysis, Gluconeogenesis, and Pyruvate Metabolism | -1.20e-01 | 2.9e-01 |
| quinate | Xenobiotics | Food Component/Plant | -1.17e+00 | 3.0e-02 |
| quinolinate | Cofactors and Vitamins | Nicotinate and Nicotinamide Metabolism | 9.60e-01 | 0.0e+00 |
| retinol (vitamin A) | Cofactors and Vitamins | Vitamin A Metabolism | -1.00e-02 | 7.9e-01 |
| ribitol | Carbohydrate | Pentose Metabolism | 0.00e+00 | 8.5e-01 |
| ribonate | Carbohydrate | Pentose Metabolism | 3.10e-01 | 1.0e-02 |
| ribose | Carbohydrate | Pentose Metabolism | 6.00e-01 | 6.0e-02 |
| ribulose/xylulose | Carbohydrate | Pentose Metabolism | 4.40e-01 | 0.0e+00 |
| S-adenosylhomocysteine (SAH) | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | 1.10e-01 | 4.9e-01 |
| S-methylcysteine | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | 4.80e-01 | 0.0e+00 |
| S-methylcysteine sulfoxide | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | 3.90e-01 | 1.3e-01 |
| S-methylglutathione | Amino Acid | Glutathione Metabolism | -4.80e-01 | 1.6e-01 |
| S-methylmethionine | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | -6.70e-01 | 1.3e-01 |
| salicylate | Xenobiotics | Drug - Topical Agents | -1.06e+00 | 0.0e+00 |
| sarcosine | Amino Acid | Glycine, Serine and Threonine Metabolism | 1.60e-01 | 9.0e-02 |
| sebacate (C10-DC) | Lipid | Fatty Acid, Dicarboxylate | 1.20e-01 | 3.5e-01 |
| sedoheptulose | Carbohydrate | Pentose Metabolism | 5.00e-01 | 1.3e-01 |
| serine | Amino Acid | Glycine, Serine and Threonine Metabolism | -1.30e-01 | 8.0e-02 |
| serotonin | Amino Acid | Tryptophan Metabolism | 2.00e-01 | 1.0e-01 |
| spermidine | Amino Acid | Polyamine Metabolism | -1.07e+00 | 0.0e+00 |
| spermine | Amino Acid | Polyamine Metabolism | -1.92e+00 | 2.0e-02 |
| sphinganine | Lipid | Sphingolipid Synthesis | -1.80e-01 | 3.8e-01 |
| sphinganine-1-phosphate | Lipid | Sphingolipid Synthesis | -4.00e-02 | 5.3e-01 |
| sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)* | Lipid | Sphingomyelins | 1.60e-01 | 4.0e-02 |
| sphingomyelin (d18:0/18:0, d19:0/17:0)* | Lipid | Dihydrosphingomyelins | 1.12e+00 | 0.0e+00 |
| sphingomyelin (d18:1/14:0, d16:1/16:0)* | Lipid | Sphingomyelins | 1.70e-01 | 7.0e-02 |
| sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) | Lipid | Sphingomyelins | 1.70e-01 | 1.2e-01 |
| sphingomyelin (d18:1/18:1, d18:2/18:0) | Lipid | Sphingomyelins | 1.60e-01 | 7.0e-02 |
| sphingomyelin (d18:1/19:0, d19:1/18:0)* | Lipid | Sphingomyelins | 5.80e-01 | 0.0e+00 |
| sphingomyelin (d18:1/20:0, d16:1/22:0)* | Lipid | Sphingomyelins | 3.50e-01 | 0.0e+00 |
| sphingomyelin (d18:1/20:1, d18:2/20:0)* | Lipid | Sphingomyelins | 2.00e-01 | 1.1e-01 |
| sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* | Lipid | Sphingomyelins | 3.20e-01 | 0.0e+00 |
| sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)* | Lipid | Sphingomyelins | 1.60e-01 | 1.0e-01 |
| sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)* | Lipid | Sphingomyelins | 1.20e-01 | 2.7e-01 |
| sphingomyelin (d18:1/24:1, d18:2/24:0)* | Lipid | Sphingomyelins | 2.40e-01 | 2.0e-02 |
| sphingomyelin (d18:1/25:0, d19:0/24:1, d20:1/23:0, d19:1/24:0)* | Lipid | Sphingomyelins | 1.80e-01 | 4.0e-02 |
| sphingomyelin (d18:2/14:0, d18:1/14:1)* | Lipid | Sphingomyelins | 1.00e-02 | 8.4e-01 |
| sphingomyelin (d18:2/16:0, d18:1/16:1)* | Lipid | Sphingomyelins | 1.70e-01 | 7.0e-02 |
| sphingomyelin (d18:2/18:1)* | Lipid | Sphingomyelins | 7.60e-01 | 0.0e+00 |
| sphingomyelin (d18:2/21:0, d16:2/23:0)* | Lipid | Sphingomyelins | 2.20e-01 | 1.4e-01 |
| sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)* | Lipid | Sphingomyelins | 2.30e-01 | 1.0e-02 |
| sphingomyelin (d18:2/23:1)* | Lipid | Sphingomyelins | 1.80e-01 | 1.4e-01 |
| sphingomyelin (d18:2/24:1, d18:1/24:2)* | Lipid | Sphingomyelins | 2.50e-01 | 1.0e-02 |
| sphingomyelin (d18:2/24:2)* | Lipid | Sphingomyelins | 2.00e-01 | 9.0e-02 |
| sphingosine | Lipid | Sphingosines | 1.10e-01 | 4.8e-01 |
| sphingosine 1-phosphate | Lipid | Sphingosines | 0.00e+00 | 9.1e-01 |
| stachydrine | Xenobiotics | Food Component/Plant | -2.70e-01 | 1.0e-02 |
| stearate (18:0) | Lipid | Long Chain Saturated Fatty Acid | 7.10e-01 | 2.0e-02 |
| stearidonate (18:4n3) | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 2.40e-01 | 2.4e-01 |
| stearoyl-arachidonoyl-glycerol (18:0/20:4) [1]* | Lipid | Diacylglycerol | 3.50e-01 | 2.0e-02 |
| stearoyl-arachidonoyl-glycerol (18:0/20:4) [2]* | Lipid | Diacylglycerol | 2.00e-01 | 1.5e-01 |
| stearoyl-linoleoyl-glycerol (18:0/18:2) [2]* | Lipid | Diacylglycerol | -3.10e-01 | 1.0e+00 |
| stearoyl sphingomyelin (d18:1/18:0) | Lipid | Sphingomyelins | 1.80e-01 | 8.0e-02 |
| stearoylcarnitine (C18) | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Long Chain Saturated) | 5.20e-01 | 0.0e+00 |
| stearoylcholine* | Lipid | Fatty Acid Metabolism (Acyl Choline) | -6.50e-01 | 7.0e-02 |
| suberate (C8-DC) | Lipid | Fatty Acid, Dicarboxylate | 3.40e-01 | 2.3e-01 |
| succinate | Energy | TCA Cycle | -3.70e-01 | 3.0e-02 |
| succinoyltaurine | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | 7.60e-01 | 1.0e-02 |
| sulfate* | Xenobiotics | Chemical | -2.50e-01 | 0.0e+00 |
| tartronate (hydroxymalonate) | Xenobiotics | Food Component/Plant | 1.60e-01 | 1.7e-01 |
| taurine | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | 6.00e-02 | 3.8e-01 |
| taurochenodeoxycholate | Lipid | Primary Bile Acid Metabolism | 7.00e-01 | 5.0e-02 |
| taurocholate | Lipid | Primary Bile Acid Metabolism | 2.60e-01 | 3.0e-01 |
| taurocholenate sulfate* | Lipid | Secondary Bile Acid Metabolism | -3.00e-01 | 4.0e-01 |
| taurocyamine | Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | -6.80e-01 | 7.0e-01 |
| taurodeoxycholate | Lipid | Secondary Bile Acid Metabolism | -3.30e-01 | 8.2e-01 |
| taurodeoxycholic acid 3-sulfate | Lipid | Secondary Bile Acid Metabolism | -3.70e-01 | 8.5e-01 |
| taurohyodeoxycholic acid | Lipid | Secondary Bile Acid Metabolism | -3.00e-01 | 8.4e-01 |
| tauroursodeoxycholate | Lipid | Secondary Bile Acid Metabolism | -5.60e-01 | 2.4e-01 |
| tetradecadienedioate (C14:2-DC)* | Lipid | Fatty Acid, Dicarboxylate | 5.10e-01 | 4.0e-02 |
| tetradecadienoate (14:2)* | Lipid | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 5.40e-01 | 0.0e+00 |
| tetradecanedioate (C14-DC) | Lipid | Fatty Acid, Dicarboxylate | 5.70e-01 | 0.0e+00 |
| thiamin (vitamin B1) | Cofactors and Vitamins | Thiamine Metabolism | -1.51e+00 | 6.0e-02 |
| thioproline | Xenobiotics | Chemical | -1.00e-01 | 9.1e-01 |
| threonate | Cofactors and Vitamins | Ascorbate and Aldarate Metabolism | 1.10e-01 | 2.0e-01 |
| threonine | Amino Acid | Glycine, Serine and Threonine Metabolism | 1.50e-01 | 5.0e-02 |
| thromboxane B2 | Lipid | Eicosanoid | 3.20e-01 | 3.3e-01 |
| thymidine | Nucleotide | Pyrimidine Metabolism, Thymine containing | 6.50e-01 | 0.0e+00 |
| thymine | Nucleotide | Pyrimidine Metabolism, Thymine containing | 6.50e-01 | 2.0e-02 |
| thyroxine | Amino Acid | Tyrosine Metabolism | -2.00e-01 | 2.0e-01 |
| tigloylglycine | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 6.00e-01 | 0.0e+00 |
| trans-3,4-methyleneheptanoylglycine | Lipid | Fatty Acid Metabolism (Acyl Glycine) | 7.10e-01 | 1.0e-02 |
| trans-4-hydroxyproline | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -5.10e-01 | 0.0e+00 |
| trans-urocanate | Amino Acid | Histidine Metabolism | 5.50e-01 | 1.0e-02 |
| tricarballylate | Energy | TCA Cycle | -1.15e+00 | 3.4e-01 |
| tricosanoyl sphingomyelin (d18:1/23:0)* | Lipid | Sphingomyelins | 3.10e-01 | 1.0e-02 |
| trigonelline (N’-methylnicotinate) | Cofactors and Vitamins | Nicotinate and Nicotinamide Metabolism | -2.40e-01 | 2.0e-02 |
| trimethylamine N-oxide | Lipid | Phospholipid Metabolism | -3.20e-01 | 1.0e-01 |
| tryptophan | Amino Acid | Tryptophan Metabolism | -2.80e-01 | 0.0e+00 |
| tyrosine | Amino Acid | Tyrosine Metabolism | -3.90e-01 | 0.0e+00 |
| undecanedioate (C11-DC) | Lipid | Fatty Acid, Dicarboxylate | -1.10e-01 | 9.6e-01 |
| uracil | Nucleotide | Pyrimidine Metabolism, Uracil containing | 2.40e-01 | 3.0e-02 |
| urate | Nucleotide | Purine Metabolism, (Hypo)Xanthine/Inosine containing | -3.20e-01 | 1.8e-01 |
| urea | Amino Acid | Urea cycle; Arginine and Proline Metabolism | -5.00e-02 | 4.6e-01 |
| uridine | Nucleotide | Pyrimidine Metabolism, Uracil containing | 2.50e-01 | 4.0e-02 |
| ursocholate | Lipid | Secondary Bile Acid Metabolism | -1.89e+00 | 0.0e+00 |
| ursodeoxycholate | Lipid | Secondary Bile Acid Metabolism | -1.32e+00 | 2.6e-01 |
| valine | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 1.07e+00 | 0.0e+00 |
| valylglycine | Peptide | Dipeptide | -3.30e-01 | 5.4e-01 |
| xanthosine | Nucleotide | Purine Metabolism, (Hypo)Xanthine/Inosine containing | -1.34e+00 | 2.0e-02 |
| xanthurenate | Amino Acid | Tryptophan Metabolism | 1.10e-01 | 4.6e-01 |
| ximenoylcarnitine (C26:1)* | Lipid | Fatty Acid Metabolism (Acyl Carnitine, Monounsaturated) | -4.30e-01 | 2.0e-01 |
| xylose | Carbohydrate | Pentose Metabolism | -6.30e-01 | 3.2e-01 |
Metabolomics %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S1. Effects of ozone on biochemical metabolites - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))rm(list = setdiff(ls(), lsf.str()))
## Load in data generated in the Curation.Rmd file found in the same src folder
load(file="../output_files/Tissue/Metabo/EnrichmentSummary.R")
EnrichmentSummary %>%
mutate(
Enrichment_Value=format(round(Enrichment_Value,2),nsmall=2,scientific=TRUE),
p_val=format(round(p_val,2),nsmall=2,scientific=TRUE),
or=format(round(or,2),nsmall=2,scientific=TRUE),
or_ll=format(round(or_ll,2),nsmall=2,scientific=TRUE),
or_ul=format(round(or_ul,2),nsmall=2,scientific=TRUE)) %>%
kable(caption = "Supplementary Table S2. Metabolomic Pathway Over-Enrichment", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>% column_spec(c(1:ncol(EnrichmentSummary)),bold=ifelse(EnrichmentSummary$p_val<.1,T,F),color= ifelse(EnrichmentSummary$p_val<.1,spec_color(EnrichmentSummary$Enrichment_Value,n=11,direction=-1,option='D'),"gray")) %>%
column_spec(c(1:ncol(EnrichmentSummary)),width="50px") %>%
scroll_box(width = "1200px", height = "500px") | Subpathway | Sig_n_in_Pathway | n_in_Pathway | Total_Metabolites | Total_Sig_Metabolites | Enrichment_Value | p_val | or | or_ll | or_ul | |
|---|---|---|---|---|---|---|---|---|---|---|
| 51 | Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 17 | 18 | 842 | 433 | 1.87e+00 | 0.0e+00 | 1.664e+01 | 3.90e+00 | Inf |
| 49 | Leucine, Isoleucine and Valine Metabolism | 21 | 27 | 842 | 433 | 1.54e+00 | 0.0e+00 | 3.420e+00 | 1.74e+00 | Inf |
| 52 | Long Chain Saturated Fatty Acid | 7 | 7 | 842 | 433 | 1.96e+00 | 1.0e-02 | Inf | 2.45e+00 | Inf |
| 10 | Diacylglycerol | 21 | 29 | 842 | 433 | 1.43e+00 | 2.0e-02 | 2.550e+00 | 1.39e+00 | Inf |
| 25 | Fatty Acid Metabolism (Acyl Carnitine, Polyunsaturated) | 6 | 6 | 842 | 433 | 1.96e+00 | 2.0e-02 | Inf | 2.04e+00 | Inf |
| 26 | Fatty Acid Metabolism (Acyl Choline) | 6 | 6 | 842 | 433 | 1.96e+00 | 2.0e-02 | Inf | 2.04e+00 | Inf |
| 34 | Food Component/Plant | 29 | 43 | 842 | 433 | 1.33e+00 | 2.0e-02 | 2.020e+00 | 1.26e+00 | Inf |
| 19 | Endocannabinoid | 6 | 7 | 842 | 433 | 1.68e+00 | 7.0e-02 | 5.720e+00 | 1.15e+00 | Inf |
| 50 | Long Chain Monounsaturated Fatty Acid | 6 | 7 | 842 | 433 | 1.68e+00 | 7.0e-02 | 5.720e+00 | 1.15e+00 | Inf |
| 64 | Phosphatidylcholine (PC) | 23 | 37 | 842 | 433 | 1.22e+00 | 1.2e-01 | 1.580e+00 | 9.60e-01 | Inf |
| 11 | Dihydrosphingomyelins | 3 | 3 | 842 | 433 | 1.95e+00 | 1.4e-01 | Inf | 8.20e-01 | Inf |
| 17 | Drug - Topical Agents | 3 | 3 | 842 | 433 | 1.95e+00 | 1.4e-01 | Inf | 8.20e-01 | Inf |
| 33 | Fatty Acid, Monohydroxy | 12 | 18 | 842 | 433 | 1.30e+00 | 1.4e-01 | 1.910e+00 | 9.00e-01 | Inf |
| 60 | Nicotinate and Nicotinamide Metabolism | 6 | 8 | 842 | 433 | 1.46e+00 | 1.6e-01 | 2.860e+00 | 8.10e-01 | Inf |
| 82 | Tryptophan Metabolism | 13 | 21 | 842 | 433 | 1.21e+00 | 2.3e-01 | 1.550e+00 | 7.90e-01 | Inf |
| 81 | Tocopherol Metabolism | 5 | 7 | 842 | 433 | 1.39e+00 | 2.5e-01 | 2.370e+00 | 6.40e-01 | Inf |
| 6 | Carnitine Metabolism | 2 | 2 | 842 | 433 | 1.95e+00 | 2.6e-01 | Inf | 4.40e-01 | Inf |
| 13 | Dipeptide Derivative | 2 | 2 | 842 | 433 | 1.95e+00 | 2.6e-01 | Inf | 4.40e-01 | Inf |
| 20 | Fatty Acid Metabolism (Acyl Carnitine, Dicarboxylate) | 2 | 2 | 842 | 433 | 1.95e+00 | 2.6e-01 | Inf | 4.40e-01 | Inf |
| 45 | Hexosylceramides (HCER) | 2 | 2 | 842 | 433 | 1.95e+00 | 2.6e-01 | Inf | 4.40e-01 | Inf |
| 83 | Tyrosine Metabolism | 7 | 11 | 842 | 433 | 1.24e+00 | 3.1e-01 | 1.660e+00 | 6.30e-01 | Inf |
| 63 | Phenylalanine Metabolism | 3 | 4 | 842 | 433 | 1.46e+00 | 3.3e-01 | 2.840e+00 | 4.50e-01 | Inf |
| 22 | Fatty Acid Metabolism (Acyl Carnitine, Long Chain Saturated) | 5 | 8 | 842 | 433 | 1.22e+00 | 3.9e-01 | 1.580e+00 | 5.00e-01 | Inf |
| 66 | Phosphatidylinositol (PI) | 5 | 8 | 842 | 433 | 1.22e+00 | 3.9e-01 | 1.580e+00 | 5.00e-01 | Inf |
| 68 | Polyamine Metabolism | 5 | 8 | 842 | 433 | 1.22e+00 | 3.9e-01 | 1.580e+00 | 5.00e-01 | Inf |
| 70 | Purine Metabolism, (Hypo)Xanthine/Inosine containing | 5 | 8 | 842 | 433 | 1.22e+00 | 3.9e-01 | 1.580e+00 | 5.00e-01 | Inf |
| 36 | Gamma-glutamyl Amino Acid | 10 | 18 | 842 | 433 | 1.08e+00 | 4.5e-01 | 1.180e+00 | 5.80e-01 | Inf |
| 5 | Biotin Metabolism | 1 | 1 | 842 | 433 | 1.95e+00 | 5.1e-01 | Inf | 1.00e-01 | Inf |
| 14 | Disaccharides and Oligosaccharides | 1 | 1 | 842 | 433 | 1.95e+00 | 5.1e-01 | Inf | 1.00e-01 | Inf |
| 15 | Docosanoid | 1 | 1 | 842 | 433 | 1.95e+00 | 5.1e-01 | Inf | 1.00e-01 | Inf |
| 16 | Drug - Cardiovascular | 1 | 1 | 842 | 433 | 1.95e+00 | 5.1e-01 | Inf | 1.00e-01 | Inf |
| 41 | Glycogen Metabolism | 1 | 1 | 842 | 433 | 1.95e+00 | 5.1e-01 | Inf | 1.00e-01 | Inf |
| 48 | Ketone Bodies | 1 | 1 | 842 | 433 | 1.95e+00 | 5.1e-01 | Inf | 1.00e-01 | Inf |
| 61 | Oxidative Phosphorylation | 1 | 1 | 842 | 433 | 1.95e+00 | 5.1e-01 | Inf | 1.00e-01 | Inf |
| 80 | Thiamine Metabolism | 1 | 1 | 842 | 433 | 1.95e+00 | 5.1e-01 | Inf | 1.00e-01 | Inf |
| 27 | Fatty Acid Metabolism (Acyl Glycine) | 2 | 3 | 842 | 433 | 1.30e+00 | 5.2e-01 | 1.890e+00 | 2.30e-01 | Inf |
| 47 | Inositol Metabolism | 2 | 3 | 842 | 433 | 1.30e+00 | 5.2e-01 | 1.890e+00 | 2.30e-01 | Inf |
| 74 | Pyrimidine Metabolism, Thymine containing | 2 | 3 | 842 | 433 | 1.30e+00 | 5.2e-01 | 1.890e+00 | 2.30e-01 | Inf |
| 21 | Fatty Acid Metabolism (Acyl Carnitine, Hydroxy) | 4 | 7 | 842 | 433 | 1.11e+00 | 5.3e-01 | 1.260e+00 | 3.60e-01 | Inf |
| 72 | Pyrimidine Metabolism, Cytidine containing | 4 | 7 | 842 | 433 | 1.11e+00 | 5.3e-01 | 1.260e+00 | 3.60e-01 | Inf |
| 59 | Monoacylglycerol | 7 | 13 | 842 | 433 | 1.05e+00 | 5.4e-01 | 1.100e+00 | 4.60e-01 | Inf |
| 4 | Benzoate Metabolism | 12 | 23 | 842 | 433 | 1.01e+00 | 5.6e-01 | 1.030e+00 | 5.50e-01 | Inf |
| 53 | Lysine Metabolism | 8 | 16 | 842 | 433 | 9.70e-01 | 6.4e-01 | 9.400e-01 | 4.40e-01 | Inf |
| 2 | Alanine and Aspartate Metabolism | 5 | 10 | 842 | 433 | 9.70e-01 | 6.6e-01 | 9.400e-01 | 3.40e-01 | Inf |
| 62 | Pentose Metabolism | 5 | 10 | 842 | 433 | 9.70e-01 | 6.6e-01 | 9.400e-01 | 3.40e-01 | Inf |
| 24 | Fatty Acid Metabolism (Acyl Carnitine, Monounsaturated) | 4 | 8 | 842 | 433 | 9.70e-01 | 6.7e-01 | 9.400e-01 | 3.00e-01 | Inf |
| 67 | Phospholipid Metabolism | 4 | 8 | 842 | 433 | 9.70e-01 | 6.7e-01 | 9.400e-01 | 3.00e-01 | Inf |
| 32 | Fatty Acid, Dihydroxy | 3 | 6 | 842 | 433 | 9.70e-01 | 6.8e-01 | 9.400e-01 | 2.40e-01 | Inf |
| 31 | Fatty Acid, Dicarboxylate | 15 | 31 | 842 | 433 | 9.40e-01 | 7.0e-01 | 8.800e-01 | 5.20e-01 | Inf |
| 9 | Creatine Metabolism | 2 | 4 | 842 | 433 | 9.70e-01 | 7.1e-01 | 9.400e-01 | 1.60e-01 | Inf |
| 18 | Eicosanoid | 2 | 4 | 842 | 433 | 9.70e-01 | 7.1e-01 | 9.400e-01 | 1.60e-01 | Inf |
| 35 | Fructose, Mannose and Galactose Metabolism | 2 | 4 | 842 | 433 | 9.70e-01 | 7.1e-01 | 9.400e-01 | 1.60e-01 | Inf |
| 73 | Pyrimidine Metabolism, Orotate containing | 2 | 4 | 842 | 433 | 9.70e-01 | 7.1e-01 | 9.400e-01 | 1.60e-01 | Inf |
| 1 | Acetylated Peptides | 1 | 2 | 842 | 433 | 9.70e-01 | 7.6e-01 | 9.400e-01 | 5.00e-02 | Inf |
| 8 | Corticosteroids | 1 | 2 | 842 | 433 | 9.70e-01 | 7.6e-01 | 9.400e-01 | 5.00e-02 | Inf |
| 29 | Fatty Acid, Amino | 1 | 2 | 842 | 433 | 9.70e-01 | 7.6e-01 | 9.400e-01 | 5.00e-02 | Inf |
| 43 | Guanidino and Acetamido Metabolism | 1 | 2 | 842 | 433 | 9.70e-01 | 7.6e-01 | 9.400e-01 | 5.00e-02 | Inf |
| 84 | Urea cycle; Arginine and Proline Metabolism | 10 | 22 | 842 | 433 | 8.80e-01 | 7.8e-01 | 7.800e-01 | 4.10e-01 | Inf |
| 78 | Sterol | 3 | 7 | 842 | 433 | 8.30e-01 | 8.0e-01 | 7.100e-01 | 1.90e-01 | Inf |
| 30 | Fatty Acid, Branched | 2 | 5 | 842 | 433 | 7.80e-01 | 8.3e-01 | 6.300e-01 | 1.20e-01 | Inf |
| 46 | Histidine Metabolism | 9 | 21 | 842 | 433 | 8.30e-01 | 8.5e-01 | 7.000e-01 | 3.60e-01 | Inf |
| 37 | Glutamate Metabolism | 4 | 10 | 842 | 433 | 7.80e-01 | 8.5e-01 | 6.300e-01 | 2.20e-01 | Inf |
| 79 | TCA Cycle | 4 | 10 | 842 | 433 | 7.80e-01 | 8.5e-01 | 6.300e-01 | 2.20e-01 | Inf |
| 56 | Medium Chain Fatty Acid | 3 | 8 | 842 | 433 | 7.30e-01 | 8.7e-01 | 5.600e-01 | 1.60e-01 | Inf |
| 39 | Glycerolipid Metabolism | 1 | 3 | 842 | 433 | 6.50e-01 | 8.9e-01 | 4.700e-01 | 3.00e-02 | Inf |
| 58 | Mevalonate Metabolism | 1 | 3 | 842 | 433 | 6.50e-01 | 8.9e-01 | 4.700e-01 | 3.00e-02 | Inf |
| 85 | Vitamin B6 Metabolism | 1 | 3 | 842 | 433 | 6.50e-01 | 8.9e-01 | 4.700e-01 | 3.00e-02 | Inf |
| 54 | Lysophospholipid | 20 | 46 | 842 | 433 | 8.40e-01 | 9.0e-01 | 7.100e-01 | 4.60e-01 | Inf |
| 76 | Secondary Bile Acid Metabolism | 7 | 18 | 842 | 433 | 7.50e-01 | 9.1e-01 | 5.900e-01 | 2.80e-01 | Inf |
| 65 | Phosphatidylethanolamine (PE) | 3 | 9 | 842 | 433 | 6.50e-01 | 9.2e-01 | 4.700e-01 | 1.40e-01 | Inf |
| 69 | Primary Bile Acid Metabolism | 3 | 9 | 842 | 433 | 6.50e-01 | 9.2e-01 | 4.700e-01 | 1.40e-01 | Inf |
| 28 | Fatty Acid Metabolism (also BCAA Metabolism) | 1 | 4 | 842 | 433 | 4.80e-01 | 9.4e-01 | 3.100e-01 | 3.00e-02 | Inf |
| 44 | Hemoglobin and Porphyrin Metabolism | 1 | 4 | 842 | 433 | 4.80e-01 | 9.4e-01 | 3.100e-01 | 3.00e-02 | Inf |
| 38 | Glutathione Metabolism | 2 | 8 | 842 | 433 | 4.80e-01 | 9.7e-01 | 3.100e-01 | 7.00e-02 | Inf |
| 55 | Lysoplasmalogen | 2 | 8 | 842 | 433 | 4.80e-01 | 9.7e-01 | 3.100e-01 | 7.00e-02 | Inf |
| 3 | Aminosugar Metabolism | 1 | 5 | 842 | 433 | 3.90e-01 | 9.7e-01 | 2.300e-01 | 2.00e-02 | Inf |
| 7 | Ceramides | 1 | 5 | 842 | 433 | 3.90e-01 | 9.7e-01 | 2.300e-01 | 2.00e-02 | Inf |
| 12 | Dipeptide | 1 | 5 | 842 | 433 | 3.90e-01 | 9.7e-01 | 2.300e-01 | 2.00e-02 | Inf |
| 23 | Fatty Acid Metabolism (Acyl Carnitine, Medium Chain) | 1 | 5 | 842 | 433 | 3.90e-01 | 9.7e-01 | 2.300e-01 | 2.00e-02 | Inf |
| 42 | Glycolysis, Gluconeogenesis, and Pyruvate Metabolism | 1 | 5 | 842 | 433 | 3.90e-01 | 9.7e-01 | 2.300e-01 | 2.00e-02 | Inf |
| 75 | Pyrimidine Metabolism, Uracil containing | 3 | 11 | 842 | 433 | 5.30e-01 | 9.7e-01 | 3.500e-01 | 1.10e-01 | Inf |
| 57 | Methionine, Cysteine, SAM and Taurine Metabolism | 8 | 24 | 842 | 433 | 6.40e-01 | 9.8e-01 | 4.600e-01 | 2.40e-01 | Inf |
| 71 | Purine Metabolism, Adenine containing | 1 | 6 | 842 | 433 | 3.20e-01 | 9.9e-01 | 1.900e-01 | 2.00e-02 | Inf |
| 77 | Sphingomyelins | 8 | 26 | 842 | 433 | 5.90e-01 | 9.9e-01 | 4.100e-01 | 2.10e-01 | Inf |
| 40 | Glycine, Serine and Threonine Metabolism | 2 | 10 | 842 | 433 | 3.90e-01 | 9.9e-01 | 2.300e-01 | 5.00e-02 | Inf |
EnrichmentSummary %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S2. Metabolomic Pathway Over-Enrichment - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))## Load in data generated in the Figures.Rmd file found in the same src folder
rm(list = setdiff(ls(), lsf.str()))
load(file="../output_files/contrasts/forUpSet.R")
## Read in excel file that I created to link each combsize identifier back to the tissues
read_excel("../input_files/combsizeID.xlsx") -> ID
make_comb_mat(genes) -> combmatrix
set_size(combmatrix) %>% as.data.frame()-> setsize
comb_size(combmatrix) %>% as.data.frame() %>% rownames_to_column(var = "combs")-> combsize
combsize$combs <- paste0("'",combsize$combs,"'")
merge(combsize,ID,by="combs") -> combs
colnames(combs) <- c("combs","Combsize","Tissues","Muscle","Adipose","Liver","Adrenal","HT","Lung")
make_comb_mat(genes,mode="intersect") -> Total
set_size(Total) %>% as.data.frame()-> Totalset
comb_size(Total) %>% as.data.frame() %>% rownames_to_column(var = "combs")-> Totalcomb
Totalcomb$combs <- paste0("'",Totalcomb$combs,"'")
merge(Totalcomb,ID,by="combs") -> Totalcombs
colnames(Totalcombs) <- c("combs","Total","Tissues","Muscle","Adipose","Liver","Adrenal","HT","Lung")
merge(combs,Totalcombs,by="combs") -> CombSummary
CombSummary[,c(3,1,2,10)] -> CombSummary
colnames(CombSummary) <- c("Tissues","Combs","Combsize","Total")
CombSummary %>% kable(caption = "Supplementary Table 3. UpSet Plot Combs", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>% scroll_box(width = "900", height = "500px")| Tissues | Combs | Combsize | Total |
|---|---|---|---|
| Lung | ‘000001’ | 658 | 1640 |
| HT | ‘000010’ | 77 | 274 |
| HT + Lung | ‘000011’ | 7 | 95 |
| Adrenal | ‘000100’ | 1261 | 2516 |
| Adrenal + Lung | ‘000101’ | 111 | 347 |
| Adrenal + HT | ‘000110’ | 5 | 65 |
| Adrenal + HT + Lung | ‘000111’ | 5 | 38 |
| Liver | ‘001000’ | 475 | 1333 |
| Liver + Lung | ‘001001’ | 62 | 269 |
| Liver + HT | ‘001010’ | 8 | 71 |
| Liver + HT + Lung | ‘001011’ | 3 | 42 |
| Liver + Adrenal | ‘001100’ | 123 | 351 |
| Liver + AdrenalLung | ‘001101’ | 18 | 92 |
| Liver + Adrenal + HT | ‘001110’ | 3 | 32 |
| Liver + Adrenal + HT + Lung | ‘001111’ | 6 | 21 |
| Adi | ‘010000’ | 355 | 1242 |
| Adi + Lung | ‘010001’ | 53 | 324 |
| Adi + HT | ‘010010’ | 4 | 70 |
| Adi + HT + Lung | ‘010011’ | 5 | 45 |
| Adi+ Adrenal | ‘010100’ | 109 | 362 |
| Adi + Adrenal + Lung | ‘010101’ | 29 | 121 |
| Adi+ Adrenal + HT | ‘010110’ | 2 | 30 |
| Adi + Adrenal + HT + Lung | ‘010111’ | 3 | 21 |
| Adi + Liver | ‘011000’ | 65 | 288 |
| Adi + Liver + Lung | ‘011001’ | 20 | 112 |
| Adi + Liver + HT | ‘011010’ | 1 | 33 |
| Adi + LiverHT + Lung | ‘011011’ | 2 | 25 |
| Adi + Liver + Adrenal | ‘011100’ | 39 | 115 |
| Adi + Liver + Adrenal + Lung | ‘011101’ | 19 | 49 |
| Adi + Liver + Adrenal + HT | ‘011110’ | 1 | 17 |
| Adi + Liver + Adrenal + HT + Lung | ‘011111’ | 6 | 12 |
| Muscle | ‘100000’ | 3335 | 5102 |
| Muscle + Lung | ‘100001’ | 293 | 633 |
| Muscle + HT | ‘100010’ | 44 | 136 |
| Muscle + HT + Lung | ‘100011’ | 18 | 58 |
| Muscle + Adrenal | ‘100100’ | 462 | 776 |
| Muscle + Adrenal+ Lung | ‘100101’ | 64 | 150 |
| Muscle + Adrenal + HT | ‘100110’ | 7 | 34 |
| Muscle + Adrenal + HT + Lung | ‘100111’ | 3 | 18 |
| Muscle + Liver | ‘101000’ | 205 | 482 |
| Muscle +Liver + Lung | ‘101001’ | 44 | 133 |
| Muscle + Liver + HT | ‘101010’ | 7 | 41 |
| Muscle + Liver + HT + Lung | ‘101011’ | 5 | 25 |
| Muscle + Liver + Adrenal | ‘101100’ | 64 | 136 |
| Muscle + Liver + Adrenal + Lung | ‘101101’ | 16 | 43 |
| Muscle + Liver + Adrenal + HT | ‘101110’ | 3 | 16 |
| Muscle + Liver + Adrenal + HT + Lung | ‘101111’ | 3 | 9 |
| Muscle + Adi | ‘110000’ | 199 | 529 |
| Muscle + Adi +Lung | ‘110001’ | 76 | 187 |
| Muscle + Adi + HT | ‘110010’ | 9 | 46 |
| Muscle + Adi + HT + Lung | ‘110011’ | 6 | 29 |
| Muscle + Adi + Adrenal | ‘110100’ | 62 | 154 |
| Muscle + Adi + Adrenal + Lung | ‘110101’ | 34 | 64 |
| Muscle + Adi + Adrenal + HT | ‘110110’ | 2 | 18 |
| Muscle + Adi + Adrenal + HT + Lung | ‘110111’ | 6 | 12 |
| Muscle + Adi + Liver | ‘111000’ | 42 | 135 |
| Muscle + Adi + Liver + Lung | ‘111001’ | 30 | 65 |
| Muscle + Adi + Liver + HT | ‘111010’ | 2 | 23 |
| Muscle + Adi + Liver + HT + Lung | ‘111011’ | 11 | 17 |
| Muscle + Adi + Liver + Adrenal | ‘111100’ | 22 | 50 |
| Muscle + Adi + Liver + Adrenal + Lung | ‘111101’ | 18 | 24 |
| Muscle + Adi + Liver + Adrenal + HT | ‘111110’ | 4 | 10 |
| Muscle + Adi + Liver + Adrenal + HT + Lung | ‘111111’ | 6 | 6 |
CombSummary %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table 3. UpSet Plot Combs - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))rm(list = setdiff(ls(), lsf.str()))
## Load in data generated in the Curation.Rmd file found in the same src folder
load("../output_files/Tissue/Adrenal/Adrenal_o3vAir.R")
load("../output_files/Tissue/Adrenal/Adipose_o3vAir.R")
load("../output_files/Tissue/Adrenal/HT_o3vAir.R")
load("../output_files/Tissue/Adrenal/Liver_o3vAir.R")
load("../output_files/Tissue/Adrenal/Lung_o3vAir.R")
load("../output_files/Tissue/Adrenal/Muscle_o3vAir.R")
AD_Hallmark <- twj_gen_XGR(data = AD1, mygo = "MsigdbH", l2fc = log2(1.5), significant_filter = 0.10)## Start at 2023-07-02 14:34:00.326855## ## Load the ontology MsigdbH and its gene annotations (2023-07-02 14:34:00.328495) ...## Start at 2023-07-02 14:34:00.329484## ## 'org.Hs.egMsigdbH' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.egMsigdbH.RData) has been loaded into the working environment (at 2023-07-02 14:34:00.735384)##
## End at 2023-07-02 14:34:00.735715## Runtime in total is: 0 secs## Do gene mapping from Symbols to EntrezIDs (2023-07-02 14:34:00.740628) ...## Start at 2023-07-02 14:34:00.741506## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:03.051191)##
## End at 2023-07-02 14:34:03.051549## Runtime in total is: 3 secs## human organism (2023-07-02 14:34:03.0522)## Among 2516 symbols of input data, there are 2136 mappable via official gene symbols but 380 left unmappable## Start at 2023-07-02 14:34:03.078331## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:04.44602)##
## End at 2023-07-02 14:34:04.446423## Runtime in total is: 1 secs## human organism (2023-07-02 14:34:04.447175)## Among 19465 symbols of input data, there are 14997 mappable via official gene symbols but 4468 left unmappable##
## ######################################################### 'xEnricher' is being called (2023-07-02 14:34:04.483664):## ######################################################### First, generate a subgraph induced (via 'all_paths' mode) by the annotation data (2023-07-02 14:34:04.487006) ...## Next, prepare enrichment analysis (2023-07-02 14:34:04.939218) ...## There are 2136 genes/SNPs of interest tested against 14996 genes/SNPs as the background (annotatable only? FALSE) (2023-07-02 14:34:04.940626)## Third, perform enrichment analysis using 'fisher' test (2023-07-02 14:34:04.946226) ...## There are 50 terms being used, each restricted within [10,2000] annotations## Last, adjust the p-values for 47 terms (with 5 minimum overlaps) using the BH method (2023-07-02 14:34:05.295302) ...## Start at 2023-07-02 14:34:05.327699## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:06.801699)##
## End at 2023-07-02 14:34:06.802027## Runtime in total is: 1 secs## ######################################################### 'xEnricher' has been finished (2023-07-02 14:34:08.783063)!## #########################################################
## End at 2023-07-02 14:34:08.785558## Runtime in total (xEnricherGenes): 8 secsAdi_Hallmark <- twj_gen_XGR(data = Adi1, mygo = "MsigdbH", l2fc = log2(1.5), significant_filter = 0.10)## Start at 2023-07-02 14:34:08.80789## ## Load the ontology MsigdbH and its gene annotations (2023-07-02 14:34:08.808422) ...## Start at 2023-07-02 14:34:08.808663## ## 'org.Hs.egMsigdbH' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.egMsigdbH.RData) has been loaded into the working environment (at 2023-07-02 14:34:09.008131)##
## End at 2023-07-02 14:34:09.008449## Runtime in total is: 1 secs## Do gene mapping from Symbols to EntrezIDs (2023-07-02 14:34:09.011758) ...## Start at 2023-07-02 14:34:09.012062## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:10.115744)##
## End at 2023-07-02 14:34:10.116073## Runtime in total is: 1 secs## human organism (2023-07-02 14:34:10.116685)## Among 1242 symbols of input data, there are 1064 mappable via official gene symbols but 178 left unmappable## Start at 2023-07-02 14:34:10.135524## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:10.919724)##
## End at 2023-07-02 14:34:10.920047## Runtime in total is: 0 secs## human organism (2023-07-02 14:34:10.920879)## Among 19465 symbols of input data, there are 14997 mappable via official gene symbols but 4468 left unmappable##
## ######################################################### 'xEnricher' is being called (2023-07-02 14:34:10.951964):## ######################################################### First, generate a subgraph induced (via 'all_paths' mode) by the annotation data (2023-07-02 14:34:10.9528) ...## Next, prepare enrichment analysis (2023-07-02 14:34:11.345904) ...## There are 1064 genes/SNPs of interest tested against 14996 genes/SNPs as the background (annotatable only? FALSE) (2023-07-02 14:34:11.347186)## Third, perform enrichment analysis using 'fisher' test (2023-07-02 14:34:11.35132) ...## There are 50 terms being used, each restricted within [10,2000] annotations## Last, adjust the p-values for 45 terms (with 5 minimum overlaps) using the BH method (2023-07-02 14:34:11.538445) ...## Start at 2023-07-02 14:34:11.561559## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:12.450063)##
## End at 2023-07-02 14:34:12.450391## Runtime in total is: 1 secs## ######################################################### 'xEnricher' has been finished (2023-07-02 14:34:14.289719)!## #########################################################
## End at 2023-07-02 14:34:14.29066## Runtime in total (xEnricherGenes): 6 secsHT_Hallmark <- twj_gen_XGR(data = HT1, mygo = "MsigdbH", l2fc = log2(1.5), significant_filter = 0.10)## Start at 2023-07-02 14:34:14.312848## ## Load the ontology MsigdbH and its gene annotations (2023-07-02 14:34:14.313331) ...## Start at 2023-07-02 14:34:14.313578## ## 'org.Hs.egMsigdbH' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.egMsigdbH.RData) has been loaded into the working environment (at 2023-07-02 14:34:14.536835)##
## End at 2023-07-02 14:34:14.537162## Runtime in total is: 0 secs## Do gene mapping from Symbols to EntrezIDs (2023-07-02 14:34:14.540853) ...## Start at 2023-07-02 14:34:14.541187## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:15.583051)##
## End at 2023-07-02 14:34:15.583381## Runtime in total is: 1 secs## human organism (2023-07-02 14:34:15.58399)## Among 274 symbols of input data, there are 231 mappable via official gene symbols but 43 left unmappable## Start at 2023-07-02 14:34:15.60223## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:16.296273)##
## End at 2023-07-02 14:34:16.296601## Runtime in total is: 1 secs## human organism (2023-07-02 14:34:16.297212)## Among 19465 symbols of input data, there are 14997 mappable via official gene symbols but 4468 left unmappable##
## ######################################################### 'xEnricher' is being called (2023-07-02 14:34:16.32854):## ######################################################### First, generate a subgraph induced (via 'all_paths' mode) by the annotation data (2023-07-02 14:34:16.329334) ...## Next, prepare enrichment analysis (2023-07-02 14:34:16.720708) ...## There are 231 genes/SNPs of interest tested against 14996 genes/SNPs as the background (annotatable only? FALSE) (2023-07-02 14:34:16.722422)## Third, perform enrichment analysis using 'fisher' test (2023-07-02 14:34:16.726674) ...## There are 50 terms being used, each restricted within [10,2000] annotations## Last, adjust the p-values for 12 terms (with 5 minimum overlaps) using the BH method (2023-07-02 14:34:16.819089) ...## Start at 2023-07-02 14:34:16.821811## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:17.662275)##
## End at 2023-07-02 14:34:17.662617## Runtime in total is: 1 secs## ######################################################### 'xEnricher' has been finished (2023-07-02 14:34:18.104006)!## #########################################################
## End at 2023-07-02 14:34:18.10473## Runtime in total (xEnricherGenes): 4 secsLiver_Hallmark <- twj_gen_XGR(data = Liver1, mygo = "MsigdbH", l2fc = log2(1.5), significant_filter = 0.10)## Start at 2023-07-02 14:34:18.126288## ## Load the ontology MsigdbH and its gene annotations (2023-07-02 14:34:18.126773) ...## Start at 2023-07-02 14:34:18.126997## ## 'org.Hs.egMsigdbH' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.egMsigdbH.RData) has been loaded into the working environment (at 2023-07-02 14:34:18.236759)##
## End at 2023-07-02 14:34:18.23708## Runtime in total is: 0 secs## Do gene mapping from Symbols to EntrezIDs (2023-07-02 14:34:18.240606) ...## Start at 2023-07-02 14:34:18.240957## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:19.03233)##
## End at 2023-07-02 14:34:19.032667## Runtime in total is: 1 secs## human organism (2023-07-02 14:34:19.033297)## Among 1333 symbols of input data, there are 1117 mappable via official gene symbols but 216 left unmappable## Start at 2023-07-02 14:34:19.052782## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:19.720165)##
## End at 2023-07-02 14:34:19.720494## Runtime in total is: 0 secs## human organism (2023-07-02 14:34:19.721259)## Among 19465 symbols of input data, there are 14997 mappable via official gene symbols but 4468 left unmappable##
## ######################################################### 'xEnricher' is being called (2023-07-02 14:34:19.751596):## ######################################################### First, generate a subgraph induced (via 'all_paths' mode) by the annotation data (2023-07-02 14:34:19.752389) ...## Next, prepare enrichment analysis (2023-07-02 14:34:20.140201) ...## There are 1117 genes/SNPs of interest tested against 14996 genes/SNPs as the background (annotatable only? FALSE) (2023-07-02 14:34:20.141512)## Third, perform enrichment analysis using 'fisher' test (2023-07-02 14:34:20.147137) ...## There are 50 terms being used, each restricted within [10,2000] annotations## Last, adjust the p-values for 45 terms (with 5 minimum overlaps) using the BH method (2023-07-02 14:34:20.522029) ...## Start at 2023-07-02 14:34:20.545748## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:21.4657)##
## End at 2023-07-02 14:34:21.466047## Runtime in total is: 1 secs## ######################################################### 'xEnricher' has been finished (2023-07-02 14:34:23.09128)!## #########################################################
## End at 2023-07-02 14:34:23.091886## Runtime in total (xEnricherGenes): 5 secsLung_Hallmark <- twj_gen_XGR(data = Lung1, mygo = "MsigdbH", l2fc = log2(1.5), significant_filter = 0.10)## Start at 2023-07-02 14:34:23.114175## ## Load the ontology MsigdbH and its gene annotations (2023-07-02 14:34:23.114687) ...## Start at 2023-07-02 14:34:23.114915## ## 'org.Hs.egMsigdbH' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.egMsigdbH.RData) has been loaded into the working environment (at 2023-07-02 14:34:23.325184)##
## End at 2023-07-02 14:34:23.325501## Runtime in total is: 0 secs## Do gene mapping from Symbols to EntrezIDs (2023-07-02 14:34:23.328765) ...## Start at 2023-07-02 14:34:23.32908## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:24.34456)##
## End at 2023-07-02 14:34:24.344895## Runtime in total is: 1 secs## human organism (2023-07-02 14:34:24.345523)## Among 1640 symbols of input data, there are 1331 mappable via official gene symbols but 309 left unmappable## Start at 2023-07-02 14:34:24.367404## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:25.049698)##
## End at 2023-07-02 14:34:25.050028## Runtime in total is: 1 secs## human organism (2023-07-02 14:34:25.05066)## Among 19465 symbols of input data, there are 14997 mappable via official gene symbols but 4468 left unmappable##
## ######################################################### 'xEnricher' is being called (2023-07-02 14:34:25.081346):## ######################################################### First, generate a subgraph induced (via 'all_paths' mode) by the annotation data (2023-07-02 14:34:25.082157) ...## Next, prepare enrichment analysis (2023-07-02 14:34:25.469379) ...## There are 1331 genes/SNPs of interest tested against 14996 genes/SNPs as the background (annotatable only? FALSE) (2023-07-02 14:34:25.470709)## Third, perform enrichment analysis using 'fisher' test (2023-07-02 14:34:25.475765) ...## There are 50 terms being used, each restricted within [10,2000] annotations## Last, adjust the p-values for 43 terms (with 5 minimum overlaps) using the BH method (2023-07-02 14:34:25.861756) ...## Start at 2023-07-02 14:34:25.885652## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:26.790692)##
## End at 2023-07-02 14:34:26.791019## Runtime in total is: 1 secs## ######################################################### 'xEnricher' has been finished (2023-07-02 14:34:28.337394)!## #########################################################
## End at 2023-07-02 14:34:28.338315## Runtime in total (xEnricherGenes): 5 secsMuscle_Hallmark <- twj_gen_XGR(data = Musc1, mygo = "MsigdbH", l2fc = log2(1.5), significant_filter = 0.10)## Start at 2023-07-02 14:34:28.362577## ## Load the ontology MsigdbH and its gene annotations (2023-07-02 14:34:28.36325) ...## Start at 2023-07-02 14:34:28.363487## ## 'org.Hs.egMsigdbH' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.egMsigdbH.RData) has been loaded into the working environment (at 2023-07-02 14:34:28.595037)##
## End at 2023-07-02 14:34:28.595346## Runtime in total is: 0 secs## Do gene mapping from Symbols to EntrezIDs (2023-07-02 14:34:28.598725) ...## Start at 2023-07-02 14:34:28.599038## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:29.632103)##
## End at 2023-07-02 14:34:29.632429## Runtime in total is: 1 secs## human organism (2023-07-02 14:34:29.633045)## Among 5102 symbols of input data, there are 4212 mappable via official gene symbols but 890 left unmappable## Start at 2023-07-02 14:34:29.654402## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:30.344128)##
## End at 2023-07-02 14:34:30.344578## Runtime in total is: 1 secs## human organism (2023-07-02 14:34:30.3454)## Among 19465 symbols of input data, there are 14997 mappable via official gene symbols but 4468 left unmappable##
## ######################################################### 'xEnricher' is being called (2023-07-02 14:34:30.375634):## ######################################################### First, generate a subgraph induced (via 'all_paths' mode) by the annotation data (2023-07-02 14:34:30.376532) ...## Next, prepare enrichment analysis (2023-07-02 14:34:30.760868) ...## There are 4212 genes/SNPs of interest tested against 14996 genes/SNPs as the background (annotatable only? FALSE) (2023-07-02 14:34:30.762435)## Third, perform enrichment analysis using 'fisher' test (2023-07-02 14:34:30.766534) ...## There are 50 terms being used, each restricted within [10,2000] annotations## Last, adjust the p-values for 50 terms (with 5 minimum overlaps) using the BH method (2023-07-02 14:34:31.486381) ...## Start at 2023-07-02 14:34:31.522273## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:32.546418)##
## End at 2023-07-02 14:34:32.546751## Runtime in total is: 1 secs## ######################################################### 'xEnricher' has been finished (2023-07-02 14:34:34.335192)!## #########################################################
## End at 2023-07-02 14:34:34.335809## Runtime in total (xEnricherGenes): 6 secsxEnrichViewer(tissue_mygo = "AD_Hallmark",eTerm = AD_Hallmark$O3_vs_Air, top_num = 50, sortBy = 'adjp', decreasing = NULL, details = F) -> ADH
xEnrichViewer(tissue_mygo = "Adi_Hallmark",eTerm = Adi_Hallmark$O3_vs_Air, top_num = 50, sortBy = 'adjp', decreasing = NULL, details = F)-> AdiH
xEnrichViewer(tissue_mygo = "HT_Hallmark",eTerm = HT_Hallmark$O3_vs_Air, top_num = 50, sortBy = 'adjp', decreasing = NULL, details = F)-> HTH
xEnrichViewer(tissue_mygo = "Liver_Hallmark",eTerm = Liver_Hallmark$O3_vs_Air, top_num = 50, sortBy = 'adjp', decreasing = NULL, details = F)-> LiverH
xEnrichViewer(tissue_mygo = "Lung_Hallmark",eTerm = Lung_Hallmark$O3_vs_Air, top_num = 50, sortBy = 'adjp', decreasing = NULL, details = F)-> LungH
xEnrichViewer(tissue_mygo = "Muscle_Hallmark",eTerm = Muscle_Hallmark$O3_vs_Air, top_num = 50, sortBy = 'adjp', decreasing = NULL, details = F)-> MuscleH
colnames(ADH)[2:ncol(ADH)] <- paste0("Adrenal_",colnames(ADH)[2:ncol(ADH)])
colnames(AdiH)[2:ncol(AdiH)] <- paste0("Adipose_",colnames(AdiH)[2:ncol(AdiH)])
colnames(HTH)[2:ncol(HTH)] <- paste0("HT_",colnames(HTH)[2:ncol(HTH)])
colnames(LiverH)[2:ncol(LiverH)] <- paste0("Liver_",colnames(LiverH)[2:ncol(LiverH)])
colnames(LungH)[2:ncol(LungH)] <- paste0("Lung_",colnames(LungH)[2:ncol(LungH)])
colnames(MuscleH)[2:ncol(MuscleH)] <- paste0("Muscle_",colnames(MuscleH)[2:ncol(MuscleH)])
ADH$Adrenal_PercentOverlap <- round((ADH$Adrenal_nOverlap/ADH$Adrenal_nAnno)*100,0)
AdiH$Adipose_PercentOverlap <- round((AdiH$Adipose_nOverlap/AdiH$Adipose_nAnno)*100)
HTH$HT_PercentOverlap <- round((HTH$HT_nOverlap/HTH$HT_nAnno)*100)
LiverH$Liver_PercentOverlap <- round((LiverH$Liver_nOverlap/LiverH$Liver_nAnno)*100)
LungH$Lung_PercentOverlap <- round((LungH$Lung_nOverlap/LungH$Lung_nAnno)*100)
MuscleH$Muscle_PercentOverlap <- round((MuscleH$Muscle_nOverlap/MuscleH$Muscle_nAnno)*100)
tissues <- list(ADH,AdiH,HTH,LiverH,LungH,MuscleH)
Hallmark <- Reduce(function(x,y)full_join(x,y,by="name"), tissues)
colnames(Hallmark) <- c("Pathway",colnames(Hallmark)[2:ncol(Hallmark)])
Hallmark[,c(1,11,4,7,21,14,17,31,24,27,41,34,37,51,44,47,61,54,57)] -> HallmarkTable
save(HallmarkTable,file="../output_files/pathways/HallmarkTable.R")rm(list = setdiff(ls(), lsf.str()))
load(file="../output_files/pathways/HallmarkTable.R")
HallmarkTable[,c(1,14:16,8:10,2:4,11:13,5:7,17:19)] -> HallmarkTable
HallmarkTable %>% mutate(
Adrenal_adjp=format(round(Adrenal_adjp,2),nsmall=2,scientific=TRUE),
Adrenal_fc=format(round(Adrenal_fc,2),nsmall=2,scientific=TRUE),
Adipose_adjp=format(round(Adipose_adjp,2),nsmall=2,scientific=TRUE),
Adipose_fc=format(round(Adipose_fc,2),nsmall=2,scientific=TRUE),
Liver_adjp=format(round(Liver_adjp,2),nsmall=2,scientific=TRUE),
Liver_fc=format(round(Liver_fc,2),nsmall=2,scientific=TRUE),
Lung_adjp=format(round(Lung_adjp,2),nsmall=2,scientific=TRUE),
Lung_fc=format(round(Lung_fc,2),nsmall=2,scientific=TRUE),
HT_adjp=format(round(HT_adjp,2),nsmall=2,scientific=TRUE),
HT_fc=format(round(HT_fc,2),nsmall=2,scientific=TRUE),
Muscle_adjp=format(round(Muscle_adjp,2),nsmall=2,scientific=TRUE),
Muscle_fc=format(round(Muscle_fc,2),nsmall=2,scientific=TRUE)) %>%
kable(caption = "Supplementary Table 4. Tissue-specific enrichment of Hallmark pathways after an acute ozone exposure", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>% column_spec(c(2:4),bold=ifelse(is.na(HallmarkTable$Adrenal_adjp),F,ifelse(HallmarkTable$Adrenal_adjp<.1,T,F)),color= ifelse(is.na(HallmarkTable$Adrenal_adjp),"gray",ifelse(HallmarkTable$Adrenal_adjp <.1,spec_color(HallmarkTable$Adrenal_fc,n=11,direction=-1,option='D'),"gray"))) %>% column_spec(c(5:7),bold=ifelse(is.na(HallmarkTable$Adipose_adjp),F,ifelse(HallmarkTable$Adipose_adjp<.1,T,F)),color= ifelse(is.na(HallmarkTable$Adipose_adjp),"gray",ifelse(HallmarkTable$Adipose_adjp <.1,spec_color(HallmarkTable$Adipose_fc,n=11,direction=-1,option='D'),"gray"))) %>% column_spec(c(8:10),bold=ifelse(is.na(HallmarkTable$HT_adjp),F,ifelse(HallmarkTable$HT_adjp<.1,T,F)),color= ifelse(is.na(HallmarkTable$HT_adjp),"gray",ifelse(HallmarkTable$HT_adjp <.1,spec_color(HallmarkTable$HT_fc,n=11,direction=-1,option='D'),"gray"))) %>% column_spec(c(11:13),bold=ifelse(is.na(HallmarkTable$Liver_adjp),F,ifelse(HallmarkTable$Liver_adjp<.1,T,F)),color= ifelse(is.na(HallmarkTable$Liver_adjp),"gray",ifelse(HallmarkTable$Liver_adjp <.1,spec_color(HallmarkTable$Liver_fc,n=11,direction=-1,option='D'),"gray"))) %>% column_spec(c(14:16),bold=ifelse(is.na(HallmarkTable$Lung_adjp),F,ifelse(HallmarkTable$Lung_adjp<.1,T,F)),color= ifelse(is.na(HallmarkTable$Lung_adjp),"gray",ifelse(HallmarkTable$Lung_adjp <.1,spec_color(HallmarkTable$Lung_fc,n=11,direction=-1,option='D'),"gray"))) %>% column_spec(c(17:19),bold=ifelse(is.na(HallmarkTable$Muscle_adjp),F,ifelse(HallmarkTable$Muscle_adjp<.1,T,F)),color= ifelse(is.na(HallmarkTable$Muscle_adjp),"gray",ifelse(HallmarkTable$Muscle_adjp <.1,spec_color(HallmarkTable$Muscle_fc,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(1:ncol(HallmarkTable)),width="100px") %>%
scroll_box(width = "1200px", height = "500px")| Pathway | Lung_PercentOverlap | Lung_fc | Lung_adjp | HT_PercentOverlap | HT_fc | HT_adjp | Adrenal_PercentOverlap | Adrenal_fc | Adrenal_adjp | Liver_PercentOverlap | Liver_fc | Liver_adjp | Adipose_PercentOverlap | Adipose_fc | Adipose_adjp | Muscle_PercentOverlap | Muscle_fc | Muscle_adjp |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genes regulated by NF-kB in response to TNF [GeneID=7124]. | 31 | 3.51e+00 | 0.0e+00 | 5 | 3.31e+00 | 1.0e-02 | 30 | 2.08e+00 | 0.0e+00 | 18 | 2.40e+00 | 0.0e+00 | 22 | 3.16e+00 | 0.0e+00 | 47 | 1.69e+00 | 0.0e+00 |
| Genes up-regulated in response to IFNG [GeneID=3458]. | 23 | 2.64e+00 | 0.0e+00 | 3 | 2.07e+00 | 1.2e-01 | 28 | 1.94e+00 | 0.0e+00 | 15 | 2.07e+00 | 0.0e+00 | 15 | 2.10e+00 | 0.0e+00 | 44 | 1.55e+00 | 0.0e+00 |
| Genes up-regulated in response to alpha interferon proteins. | 19 | 2.18e+00 | 0.0e+00 | NA | NA | NA | 32 | 2.26e+00 | 0.0e+00 | 19 | 2.60e+00 | 0.0e+00 | 13 | 1.82e+00 | 9.0e-02 | 44 | 1.57e+00 | 0.0e+00 |
| Genes defining early response to estrogen. | 17 | 1.97e+00 | 0.0e+00 | 5 | 3.09e+00 | 1.0e-02 | 25 | 1.75e+00 | 0.0e+00 | 12 | 1.63e+00 | 6.0e-02 | 15 | 2.09e+00 | 0.0e+00 | 40 | 1.41e+00 | 0.0e+00 |
| Genes up-regulated in response to low oxygen levels (hypoxia). | 23 | 2.59e+00 | 0.0e+00 | 5 | 3.12e+00 | 1.0e-02 | 25 | 1.73e+00 | 0.0e+00 | 16 | 2.15e+00 | 0.0e+00 | 17 | 2.34e+00 | 0.0e+00 | 48 | 1.69e+00 | 0.0e+00 |
| Genes up-regulated by STAT5 in response to IL2 stimulation. | 20 | 2.22e+00 | 0.0e+00 | NA | NA | NA | 22 | 1.56e+00 | 1.0e-02 | 10 | 1.32e+00 | 2.2e-01 | 18 | 2.56e+00 | 0.0e+00 | 37 | 1.31e+00 | 1.0e-02 |
| Genes up-regulated by IL6 [GeneID=3569] via STAT3 [GeneID=6774], e.g., during acute phase response. | 17 | 1.88e+00 | 4.0e-02 | NA | NA | NA | 26 | 1.84e+00 | 2.0e-02 | 12 | 1.60e+00 | 1.8e-01 | 13 | 1.85e+00 | 9.0e-02 | 43 | 1.53e+00 | 1.0e-02 |
| Genes defining response to androgens. | 6 | 7.00e-01 | 1.0e+00 | 7 | 4.68e+00 | 1.0e-02 | 25 | 1.74e+00 | 2.0e-02 | 16 | 2.21e+00 | 1.0e-02 | 21 | 2.91e+00 | 0.0e+00 | 37 | 1.32e+00 | 6.0e-02 |
| Genes encoding cell cycle related targets of E2F transcription factors. | 4 | 4.70e-01 | 1.0e+00 | NA | NA | NA | 21 | 1.51e+00 | 2.0e-02 | 10 | 1.41e+00 | 1.6e-01 | 7 | 9.60e-01 | 8.0e-01 | 22 | 7.80e-01 | 1.0e+00 |
| Genes up-regulated through activation of mTORC1 complex. | 10 | 1.08e+00 | 6.1e-01 | 3 | 1.64e+00 | 1.9e-01 | 21 | 1.45e+00 | 4.0e-02 | 15 | 1.97e+00 | 0.0e+00 | 12 | 1.64e+00 | 5.0e-02 | 35 | 1.24e+00 | 4.0e-02 |
| Genes defining late response to estrogen. | 12 | 1.31e+00 | 2.3e-01 | 4 | 2.40e+00 | 6.0e-02 | 21 | 1.45e+00 | 4.0e-02 | 8 | 1.14e+00 | 4.3e-01 | 9 | 1.27e+00 | 3.4e-01 | 39 | 1.38e+00 | 0.0e+00 |
| Genes involved in the G2/M checkpoint, as in progression through the cell division cycle. | 8 | 8.70e-01 | 9.2e-01 | NA | NA | NA | 20 | 1.41e+00 | 6.0e-02 | 11 | 1.45e+00 | 1.3e-01 | 8 | 1.09e+00 | 6.5e-01 | 26 | 9.20e-01 | 9.2e-01 |
| Genes up-regulated in response to ultraviolet (UV) radiation. | 14 | 1.58e+00 | 6.0e-02 | NA | NA | NA | 21 | 1.45e+00 | 7.0e-02 | 12 | 1.61e+00 | 8.0e-02 | 10 | 1.41e+00 | 2.4e-01 | 38 | 1.35e+00 | 1.0e-02 |
| A subgroup of genes regulated by MYC - version 2 (v2). | 9 | 9.90e-01 | 8.6e-01 | NA | NA | NA | 23 | 1.60e+00 | 1.8e-01 | 16 | 2.12e+00 | 7.0e-02 | 18 | 2.47e+00 | 3.0e-02 | 32 | 1.12e+00 | 4.5e-01 |
| Genes defining inflammatory response. | 25 | 2.77e+00 | 0.0e+00 | 5 | 3.00e+00 | 1.0e-02 | 18 | 1.26e+00 | 2.7e-01 | 9 | 1.24e+00 | 2.9e-01 | 15 | 2.10e+00 | 0.0e+00 | 45 | 1.59e+00 | 0.0e+00 |
| Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. | 16 | 1.78e+00 | 0.0e+00 | 3 | 1.71e+00 | 1.9e-01 | 18 | 1.26e+00 | 2.7e-01 | 10 | 1.34e+00 | 2.1e-01 | 9 | 1.34e+00 | 2.5e-01 | 59 | 2.10e+00 | 0.0e+00 |
| Genes involved in p53 pathways and networks. | 18 | 2.01e+00 | 0.0e+00 | NA | NA | NA | 17 | 1.21e+00 | 3.6e-01 | 13 | 1.69e+00 | 4.0e-02 | 16 | 2.21e+00 | 0.0e+00 | 36 | 1.29e+00 | 2.0e-02 |
| Genes up-regulated by KRAS activation. | 17 | 1.95e+00 | 0.0e+00 | 3 | 1.75e+00 | 1.9e-01 | 17 | 1.21e+00 | 3.6e-01 | 8 | 1.09e+00 | 4.9e-01 | 10 | 1.45e+00 | 1.6e-01 | 47 | 1.67e+00 | 0.0e+00 |
| Genes up-regulated by activation of WNT signaling through accumulation of beta catenin CTNNB1 [GeneID=1499]. | NA | NA | NA | NA | NA | NA | 21 | 1.48e+00 | 3.7e-01 | 13 | 1.77e+00 | 2.3e-01 | 13 | 1.85e+00 | 2.5e-01 | 45 | 1.59e+00 | 4.0e-02 |
| Genes encoding components of peroxisome. | NA | NA | NA | NA | NA | NA | 18 | 1.28e+00 | 3.7e-01 | 9 | 1.22e+00 | 4.3e-01 | 5 | 7.10e-01 | 9.0e-01 | 28 | 1.01e+00 | 6.8e-01 |
| Genes up-regulated during production of male gametes (sperm), as in spermatogenesis. | 8 | 9.00e-01 | 8.9e-01 | NA | NA | NA | 18 | 1.25e+00 | 3.7e-01 | 6 | 8.40e-01 | 8.1e-01 | 4 | 6.30e-01 | 9.5e-01 | 15 | 5.40e-01 | 1.0e+00 |
| Genes down-regulated by KRAS activation. | 18 | 2.04e+00 | 0.0e+00 | NA | NA | NA | 17 | 1.19e+00 | 3.8e-01 | 10 | 1.33e+00 | 2.2e-01 | 8 | 1.07e+00 | 6.6e-01 | 30 | 1.08e+00 | 4.0e-01 |
| Genes important for mitotic spindle assembly. | 5 | 5.70e-01 | 1.0e+00 | NA | NA | NA | 17 | 1.17e+00 | 3.8e-01 | 8 | 1.08e+00 | 4.9e-01 | 7 | 9.20e-01 | 8.2e-01 | 28 | 9.90e-01 | 7.1e-01 |
| Genes involve in metabolism of bile acids and salts. | 15 | 1.74e+00 | 4.0e-02 | NA | NA | NA | 17 | 1.21e+00 | 4.0e-01 | 14 | 1.83e+00 | 6.0e-02 | 8 | 1.15e+00 | 6.3e-01 | 28 | 1.00e+00 | 6.8e-01 |
| Genes encoding components of the complement system, which is part of the innate immune system. | 17 | 1.87e+00 | 0.0e+00 | NA | NA | NA | 17 | 1.16e+00 | 4.0e-01 | 7 | 8.90e-01 | 7.9e-01 | 7 | 9.30e-01 | 8.2e-01 | 38 | 1.34e+00 | 1.0e-02 |
| Genes mediating programmed cell death (apoptosis) by activation of caspases. | 19 | 2.09e+00 | 0.0e+00 | 3 | 2.08e+00 | 1.2e-01 | 17 | 1.17e+00 | 4.0e-01 | 11 | 1.46e+00 | 1.6e-01 | 12 | 1.72e+00 | 5.0e-02 | 35 | 1.23e+00 | 8.0e-02 |
| Genes up-regulated during formation of blood vessels (angiogenesis). | 14 | 1.56e+00 | 3.6e-01 | NA | NA | NA | 19 | 1.37e+00 | 4.3e-01 | NA | NA | NA | NA | NA | NA | 47 | 1.68e+00 | 3.0e-02 |
| Genes up-regulated by activation of Notch signaling. | NA | NA | NA | NA | NA | NA | 19 | 1.32e+00 | 5.0e-01 | 22 | 2.94e+00 | 4.0e-02 | 22 | 3.08e+00 | 3.0e-02 | 47 | 1.67e+00 | 4.0e-02 |
| Genes up-regulated during transplant rejection. | 19 | 2.11e+00 | 0.0e+00 | NA | NA | NA | 15 | 1.08e+00 | 5.9e-01 | 9 | 1.14e+00 | 4.3e-01 | 7 | 9.60e-01 | 8.0e-01 | 38 | 1.34e+00 | 1.0e-02 |
| Genes encoding proteins involved in glycolysis and gluconeogenesis. | 7 | 7.70e-01 | 1.0e+00 | NA | NA | NA | 15 | 1.07e+00 | 5.9e-01 | 9 | 1.27e+00 | 2.5e-01 | 7 | 1.04e+00 | 7.0e-01 | 32 | 1.12e+00 | 2.6e-01 |
| Genes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum. | 8 | 9.10e-01 | 8.9e-01 | NA | NA | NA | 15 | 1.08e+00 | 6.3e-01 | 15 | 2.06e+00 | 2.0e-02 | 6 | 8.90e-01 | 8.2e-01 | 27 | 9.60e-01 | 7.7e-01 |
| Genes involved in development of skeletal muscle (myogenesis). | 10 | 1.09e+00 | 6.1e-01 | 3 | 1.98e+00 | 1.2e-01 | 15 | 1.03e+00 | 6.7e-01 | 8 | 1.02e+00 | 6.0e-01 | 7 | 1.00e+00 | 7.6e-01 | 51 | 1.81e+00 | 0.0e+00 |
| Genes encoding components of apical junction complex. | 11 | 1.22e+00 | 3.6e-01 | NA | NA | NA | 14 | 1.01e+00 | 7.1e-01 | 12 | 1.59e+00 | 6.0e-02 | 6 | 8.70e-01 | 8.2e-01 | 42 | 1.49e+00 | 0.0e+00 |
| Genes down-regulated in response to ultraviolet (UV) radiation. | 13 | 1.52e+00 | 9.0e-02 | NA | NA | NA | 14 | 1.00e+00 | 7.5e-01 | 10 | 1.33e+00 | 2.5e-01 | 12 | 1.70e+00 | 7.0e-02 | 44 | 1.57e+00 | 0.0e+00 |
| Genes involved in cholesterol homeostasis. | 11 | 1.25e+00 | 5.1e-01 | NA | NA | NA | 14 | 9.80e-01 | 7.8e-01 | 14 | 1.86e+00 | 1.0e-01 | 11 | 1.57e+00 | 2.6e-01 | 38 | 1.34e+00 | 9.0e-02 |
| Genes involved in DNA repair. | 3 | 3.90e-01 | 1.0e+00 | NA | NA | NA | 14 | 9.60e-01 | 7.8e-01 | 4 | 5.50e-01 | 9.7e-01 | 3 | 4.80e-01 | 1.0e+00 | 24 | 8.50e-01 | 9.6e-01 |
| Genes involved in metabolism of heme (a cofactor consisting of iron and porphyrin) and erythroblast differentiation. | 8 | 8.70e-01 | 9.2e-01 | NA | NA | NA | 14 | 9.60e-01 | 7.8e-01 | 10 | 1.33e+00 | 2.2e-01 | 10 | 1.39e+00 | 2.1e-01 | 30 | 1.06e+00 | 4.6e-01 |
| Genes encoding proteins over-represented on the apical surface of epithelial cells, e.g., important for cell polarity (apical area). | NA | NA | NA | NA | NA | NA | 12 | 8.60e-01 | 8.6e-01 | 17 | 2.29e+00 | 8.0e-02 | NA | NA | NA | 46 | 1.65e+00 | 2.0e-02 |
| Genes encoding components of blood coagulation system; also up-regulated in platelets. | 18 | 2.06e+00 | 0.0e+00 | NA | NA | NA | 13 | 9.10e-01 | 8.6e-01 | 4 | 5.10e-01 | 9.7e-01 | 5 | 7.50e-01 | 9.0e-01 | 40 | 1.44e+00 | 1.0e-02 |
| Genes encoding proteins involved in processing of drugs and other xenobiotics. | 18 | 2.00e+00 | 0.0e+00 | NA | NA | NA | 13 | 9.10e-01 | 8.6e-01 | 16 | 2.09e+00 | 0.0e+00 | 8 | 1.14e+00 | 5.9e-01 | 33 | 1.17e+00 | 1.5e-01 |
| Genes up-regulated in response to TGFB1 [GeneID=7040]. | 13 | 1.46e+00 | 3.6e-01 | NA | NA | NA | 11 | 7.80e-01 | 9.2e-01 | NA | NA | NA | 20 | 2.87e+00 | 1.0e-02 | 33 | 1.19e+00 | 3.7e-01 |
| Genes up-regulated by activation of the PI3K/AKT/mTOR pathway. | 8 | 8.90e-01 | 8.9e-01 | NA | NA | NA | 11 | 7.60e-01 | 9.6e-01 | 6 | 8.00e-01 | 8.3e-01 | 6 | 8.40e-01 | 8.2e-01 | 22 | 7.80e-01 | 1.0e+00 |
| Genes involved in protein secretion pathway. | NA | NA | NA | NA | NA | NA | 11 | 7.50e-01 | 9.6e-01 | NA | NA | NA | NA | NA | NA | 20 | 7.20e-01 | 1.0e+00 |
| A subgroup of genes regulated by MYC - version 1 (v1). | 3 | 2.80e-01 | 1.0e+00 | NA | NA | NA | 11 | 7.80e-01 | 9.9e-01 | 7 | 9.40e-01 | 7.2e-01 | 8 | 1.06e+00 | 6.6e-01 | 25 | 8.80e-01 | 9.6e-01 |
| Genes up-regulated during adipocyte differentiation (adipogenesis). | 5 | 5.80e-01 | 1.0e+00 | NA | NA | NA | 10 | 7.30e-01 | 9.9e-01 | 12 | 1.60e+00 | 6.0e-02 | 11 | 1.53e+00 | 9.0e-02 | 30 | 1.07e+00 | 4.2e-01 |
| Genes encoding proteins involved in metabolism of fatty acids. | 8 | 9.30e-01 | 8.9e-01 | NA | NA | NA | 10 | 6.70e-01 | 9.9e-01 | 11 | 1.47e+00 | 1.6e-01 | 6 | 8.70e-01 | 8.2e-01 | 31 | 1.10e+00 | 3.9e-01 |
| Genes encoding proteins involved in oxidative phosphorylation. | 4 | 4.00e-01 | 1.0e+00 | NA | NA | NA | 7 | 4.60e-01 | 1.0e+00 | 5 | 6.10e-01 | 9.7e-01 | 3 | 4.30e-01 | 1.0e+00 | 27 | 9.60e-01 | 8.0e-01 |
| Genes up-regulated by activation of hedgehog signaling. | 14 | 1.56e+00 | 3.6e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA | 17 | 2.35e+00 | 1.0e-01 | 44 | 1.58e+00 | 5.0e-02 |
| Genes specifically up-regulated in pancreatic beta cells. | NA | NA | NA | NA | NA | NA | NA | NA | NA | 16 | 2.10e+00 | 1.7e-01 | NA | NA | NA | 22 | 7.80e-01 | 9.5e-01 |
| Genes up-regulated by reactive oxigen species (ROS). | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 39 | 1.39e+00 | 1.2e-01 |
HallmarkTable %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table 4. Tissue-specific enrichment of Hallmark pathways after an acute ozone exposure - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))rm(list = setdiff(ls(), lsf.str()))
## Load in data generated in the Curation.Rmd file found in the same src folder
load("../output_files/Tissue/Adrenal/Adrenal_o3vAir.R")
load("../output_files/Tissue/Adrenal/Adipose_o3vAir.R")
load("../output_files/Tissue/Adrenal/HT_o3vAir.R")
load("../output_files/Tissue/Adrenal/Liver_o3vAir.R")
load("../output_files/Tissue/Adrenal/Lung_o3vAir.R")
load("../output_files/Tissue/Adrenal/Muscle_o3vAir.R")
AD_Reactome <- twj_gen_XGR(data = AD1, mygo = "MsigdbC2REACTOME", l2fc = log2(1.5), significant_filter = 0.10)## Start at 2023-07-02 14:34:36.476561## ## Load the ontology MsigdbC2REACTOME and its gene annotations (2023-07-02 14:34:36.477954) ...## Start at 2023-07-02 14:34:36.478394## ## 'org.Hs.egMsigdbC2REACTOME' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.egMsigdbC2REACTOME.RData) has been loaded into the working environment (at 2023-07-02 14:34:36.814152)##
## End at 2023-07-02 14:34:36.814463## Runtime in total is: 0 secs## Do gene mapping from Symbols to EntrezIDs (2023-07-02 14:34:36.818086) ...## Start at 2023-07-02 14:34:36.818416## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:37.734259)##
## End at 2023-07-02 14:34:37.734597## Runtime in total is: 1 secs## human organism (2023-07-02 14:34:37.735214)## Among 2516 symbols of input data, there are 2136 mappable via official gene symbols but 380 left unmappable## Start at 2023-07-02 14:34:37.754## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:38.443647)##
## End at 2023-07-02 14:34:38.444086## Runtime in total is: 1 secs## human organism (2023-07-02 14:34:38.444901)## Among 19465 symbols of input data, there are 14997 mappable via official gene symbols but 4468 left unmappable##
## ######################################################### 'xEnricher' is being called (2023-07-02 14:34:38.477523):## ######################################################### First, generate a subgraph induced (via 'all_paths' mode) by the annotation data (2023-07-02 14:34:38.478612) ...## Next, prepare enrichment analysis (2023-07-02 14:34:43.813743) ...## There are 2136 genes/SNPs of interest tested against 14996 genes/SNPs as the background (annotatable only? FALSE) (2023-07-02 14:34:43.815205)## Third, perform enrichment analysis using 'fisher' test (2023-07-02 14:34:43.836838) ...## There are 622 terms being used, each restricted within [10,2000] annotations## Last, adjust the p-values for 232 terms (with 5 minimum overlaps) using the BH method (2023-07-02 14:34:47.565997) ...## Start at 2023-07-02 14:34:48.141947## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:34:49.954748)##
## End at 2023-07-02 14:34:49.955082## Runtime in total is: 1 secs## ######################################################### 'xEnricher' has been finished (2023-07-02 14:34:58.889843)!## #########################################################
## End at 2023-07-02 14:34:58.890512## Runtime in total (xEnricherGenes): 22 secsAdi_Reactome <- twj_gen_XGR(data = Adi1, mygo = "MsigdbC2REACTOME", l2fc = log2(1.5), significant_filter = 0.10)## Start at 2023-07-02 14:34:58.915072## ## Load the ontology MsigdbC2REACTOME and its gene annotations (2023-07-02 14:34:58.915624) ...## Start at 2023-07-02 14:34:58.915882## ## 'org.Hs.egMsigdbC2REACTOME' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.egMsigdbC2REACTOME.RData) has been loaded into the working environment (at 2023-07-02 14:34:59.329959)##
## End at 2023-07-02 14:34:59.330296## Runtime in total is: 1 secs## Do gene mapping from Symbols to EntrezIDs (2023-07-02 14:34:59.333981) ...## Start at 2023-07-02 14:34:59.334326## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:35:01.049913)##
## End at 2023-07-02 14:35:01.050272## Runtime in total is: 2 secs## human organism (2023-07-02 14:35:01.050891)## Among 1242 symbols of input data, there are 1064 mappable via official gene symbols but 178 left unmappable## Start at 2023-07-02 14:35:01.069551## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:35:02.271534)##
## End at 2023-07-02 14:35:02.271879## Runtime in total is: 1 secs## human organism (2023-07-02 14:35:02.272503)## Among 19465 symbols of input data, there are 14997 mappable via official gene symbols but 4468 left unmappable##
## ######################################################### 'xEnricher' is being called (2023-07-02 14:35:02.303993):## ######################################################### First, generate a subgraph induced (via 'all_paths' mode) by the annotation data (2023-07-02 14:35:02.305254) ...## Next, prepare enrichment analysis (2023-07-02 14:35:07.406261) ...## There are 1064 genes/SNPs of interest tested against 14996 genes/SNPs as the background (annotatable only? FALSE) (2023-07-02 14:35:07.407622)## Third, perform enrichment analysis using 'fisher' test (2023-07-02 14:35:07.430738) ...## There are 622 terms being used, each restricted within [10,2000] annotations## Last, adjust the p-values for 139 terms (with 5 minimum overlaps) using the BH method (2023-07-02 14:35:09.782062) ...## Start at 2023-07-02 14:35:09.989922## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:35:11.895297)##
## End at 2023-07-02 14:35:11.895641## Runtime in total is: 2 secs## ######################################################### 'xEnricher' has been finished (2023-07-02 14:35:17.075887)!## #########################################################
## End at 2023-07-02 14:35:17.076852## Runtime in total (xEnricherGenes): 19 secsHT_Reactome <- twj_gen_XGR(data = HT1, mygo = "MsigdbC2REACTOME", l2fc = log2(1.5), significant_filter = 0.10)## Start at 2023-07-02 14:35:17.100168## ## Load the ontology MsigdbC2REACTOME and its gene annotations (2023-07-02 14:35:17.100706) ...## Start at 2023-07-02 14:35:17.100952## ## 'org.Hs.egMsigdbC2REACTOME' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.egMsigdbC2REACTOME.RData) has been loaded into the working environment (at 2023-07-02 14:35:17.523866)##
## End at 2023-07-02 14:35:17.524199## Runtime in total is: 0 secs## Do gene mapping from Symbols to EntrezIDs (2023-07-02 14:35:17.528013) ...## Start at 2023-07-02 14:35:17.528617## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:35:19.392786)##
## End at 2023-07-02 14:35:19.393119## Runtime in total is: 2 secs## human organism (2023-07-02 14:35:19.393741)## Among 274 symbols of input data, there are 231 mappable via official gene symbols but 43 left unmappable## Start at 2023-07-02 14:35:19.412364## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:35:20.700611)##
## End at 2023-07-02 14:35:20.70096## Runtime in total is: 1 secs## human organism (2023-07-02 14:35:20.701581)## Among 19465 symbols of input data, there are 14997 mappable via official gene symbols but 4468 left unmappable##
## ######################################################### 'xEnricher' is being called (2023-07-02 14:35:20.733075):## ######################################################### First, generate a subgraph induced (via 'all_paths' mode) by the annotation data (2023-07-02 14:35:20.73388) ...## Next, prepare enrichment analysis (2023-07-02 14:35:25.753926) ...## There are 231 genes/SNPs of interest tested against 14996 genes/SNPs as the background (annotatable only? FALSE) (2023-07-02 14:35:25.755652)## Third, perform enrichment analysis using 'fisher' test (2023-07-02 14:35:25.779722) ...## There are 622 terms being used, each restricted within [10,2000] annotations## Last, adjust the p-values for 21 terms (with 5 minimum overlaps) using the BH method (2023-07-02 14:35:26.747018) ...## Start at 2023-07-02 14:35:26.75304## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:35:28.681594)##
## End at 2023-07-02 14:35:28.682068## Runtime in total is: 2 secs## ######################################################### 'xEnricher' has been finished (2023-07-02 14:35:29.450143)!## #########################################################
## End at 2023-07-02 14:35:29.450834## Runtime in total (xEnricherGenes): 12 secsLiver_Reactome <- twj_gen_XGR(data = Liver1, mygo = "MsigdbC2REACTOME", l2fc = log2(1.5), significant_filter = 0.10)## Start at 2023-07-02 14:35:29.473885## ## Load the ontology MsigdbC2REACTOME and its gene annotations (2023-07-02 14:35:29.474399) ...## Start at 2023-07-02 14:35:29.474672## ## 'org.Hs.egMsigdbC2REACTOME' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.egMsigdbC2REACTOME.RData) has been loaded into the working environment (at 2023-07-02 14:35:29.793846)##
## End at 2023-07-02 14:35:29.794166## Runtime in total is: 0 secs## Do gene mapping from Symbols to EntrezIDs (2023-07-02 14:35:29.797762) ...## Start at 2023-07-02 14:35:29.798097## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:35:31.093269)##
## End at 2023-07-02 14:35:31.093627## Runtime in total is: 2 secs## human organism (2023-07-02 14:35:31.094226)## Among 1333 symbols of input data, there are 1117 mappable via official gene symbols but 216 left unmappable## Start at 2023-07-02 14:35:31.114069## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:35:32.22414)##
## End at 2023-07-02 14:35:32.224478## Runtime in total is: 1 secs## human organism (2023-07-02 14:35:32.225101)## Among 19465 symbols of input data, there are 14997 mappable via official gene symbols but 4468 left unmappable##
## ######################################################### 'xEnricher' is being called (2023-07-02 14:35:32.256933):## ######################################################### First, generate a subgraph induced (via 'all_paths' mode) by the annotation data (2023-07-02 14:35:32.257743) ...## Next, prepare enrichment analysis (2023-07-02 14:35:38.14892) ...## There are 1117 genes/SNPs of interest tested against 14996 genes/SNPs as the background (annotatable only? FALSE) (2023-07-02 14:35:38.150052)## Third, perform enrichment analysis using 'fisher' test (2023-07-02 14:35:38.170455) ...## There are 622 terms being used, each restricted within [10,2000] annotations## Last, adjust the p-values for 140 terms (with 5 minimum overlaps) using the BH method (2023-07-02 14:35:40.36512) ...## Start at 2023-07-02 14:35:40.567262## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:35:41.869715)##
## End at 2023-07-02 14:35:41.870056## Runtime in total is: 1 secs## ######################################################### 'xEnricher' has been finished (2023-07-02 14:35:47.049171)!## #########################################################
## End at 2023-07-02 14:35:47.049786## Runtime in total (xEnricherGenes): 18 secsLung_Reactome <- twj_gen_XGR(data = Lung1, mygo = "MsigdbC2REACTOME", l2fc = log2(1.5), significant_filter = 0.10)## Start at 2023-07-02 14:35:47.073186## ## Load the ontology MsigdbC2REACTOME and its gene annotations (2023-07-02 14:35:47.073708) ...## Start at 2023-07-02 14:35:47.073983## ## 'org.Hs.egMsigdbC2REACTOME' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.egMsigdbC2REACTOME.RData) has been loaded into the working environment (at 2023-07-02 14:35:47.494114)##
## End at 2023-07-02 14:35:47.494443## Runtime in total is: 0 secs## Do gene mapping from Symbols to EntrezIDs (2023-07-02 14:35:47.497888) ...## Start at 2023-07-02 14:35:47.49822## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:35:48.884316)##
## End at 2023-07-02 14:35:48.884647## Runtime in total is: 1 secs## human organism (2023-07-02 14:35:48.885255)## Among 1640 symbols of input data, there are 1331 mappable via official gene symbols but 309 left unmappable## Start at 2023-07-02 14:35:48.901866## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:35:49.991138)##
## End at 2023-07-02 14:35:49.991496## Runtime in total is: 1 secs## human organism (2023-07-02 14:35:49.992095)## Among 19465 symbols of input data, there are 14997 mappable via official gene symbols but 4468 left unmappable##
## ######################################################### 'xEnricher' is being called (2023-07-02 14:35:50.022223):## ######################################################### First, generate a subgraph induced (via 'all_paths' mode) by the annotation data (2023-07-02 14:35:50.023016) ...## Next, prepare enrichment analysis (2023-07-02 14:35:55.09044) ...## There are 1331 genes/SNPs of interest tested against 14996 genes/SNPs as the background (annotatable only? FALSE) (2023-07-02 14:35:55.091744)## Third, perform enrichment analysis using 'fisher' test (2023-07-02 14:35:55.300401) ...## There are 622 terms being used, each restricted within [10,2000] annotations## Last, adjust the p-values for 130 terms (with 5 minimum overlaps) using the BH method (2023-07-02 14:35:57.802664) ...## Start at 2023-07-02 14:35:57.983644## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:35:59.754268)##
## End at 2023-07-02 14:35:59.754628## Runtime in total is: 2 secs## ######################################################### 'xEnricher' has been finished (2023-07-02 14:36:04.6009)!## #########################################################
## End at 2023-07-02 14:36:04.60182## Runtime in total (xEnricherGenes): 17 secsMuscle_Reactome <- twj_gen_XGR(data = Musc1, mygo = "MsigdbC2REACTOME", l2fc = log2(1.5), significant_filter = 0.10)## Start at 2023-07-02 14:36:04.627067## ## Load the ontology MsigdbC2REACTOME and its gene annotations (2023-07-02 14:36:04.627701) ...## Start at 2023-07-02 14:36:04.627934## ## 'org.Hs.egMsigdbC2REACTOME' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.egMsigdbC2REACTOME.RData) has been loaded into the working environment (at 2023-07-02 14:36:05.041618)##
## End at 2023-07-02 14:36:05.042022## Runtime in total is: 1 secs## Do gene mapping from Symbols to EntrezIDs (2023-07-02 14:36:05.045524) ...## Start at 2023-07-02 14:36:05.045855## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:36:06.41968)##
## End at 2023-07-02 14:36:06.420044## Runtime in total is: 1 secs## human organism (2023-07-02 14:36:06.420662)## Among 5102 symbols of input data, there are 4212 mappable via official gene symbols but 890 left unmappable## Start at 2023-07-02 14:36:06.442338## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:36:07.555058)##
## End at 2023-07-02 14:36:07.555423## Runtime in total is: 1 secs## human organism (2023-07-02 14:36:07.556036)## Among 19465 symbols of input data, there are 14997 mappable via official gene symbols but 4468 left unmappable##
## ######################################################### 'xEnricher' is being called (2023-07-02 14:36:07.585453):## ######################################################### First, generate a subgraph induced (via 'all_paths' mode) by the annotation data (2023-07-02 14:36:07.586322) ...## Next, prepare enrichment analysis (2023-07-02 14:36:12.822942) ...## There are 4212 genes/SNPs of interest tested against 14996 genes/SNPs as the background (annotatable only? FALSE) (2023-07-02 14:36:12.824364)## Third, perform enrichment analysis using 'fisher' test (2023-07-02 14:36:12.845204) ...## There are 622 terms being used, each restricted within [10,2000] annotations## Last, adjust the p-values for 464 terms (with 5 minimum overlaps) using the BH method (2023-07-02 14:36:19.786494) ...## Start at 2023-07-02 14:36:22.708402## ## 'org.Hs.eg' (from http://galahad.well.ox.ac.uk/bigdata/org.Hs.eg.RData) has been loaded into the working environment (at 2023-07-02 14:36:23.88278)##
## End at 2023-07-02 14:36:23.883108## Runtime in total is: 1 secs## ######################################################### 'xEnricher' has been finished (2023-07-02 14:36:41.270482)!## #########################################################
## End at 2023-07-02 14:36:41.271202## Runtime in total (xEnricherGenes): 37 secsxEnrichViewer(tissue_mygo = "AD_Reactome",eTerm = AD_Reactome$O3_vs_Air, top_num = 50, sortBy = 'adjp', decreasing = NULL, details = F) -> ADR
xEnrichViewer(tissue_mygo = "Adi_Reactome",eTerm = Adi_Reactome$O3_vs_Air, top_num = 50, sortBy = 'adjp', decreasing = NULL, details = F)-> AdiR
xEnrichViewer(tissue_mygo = "HT_Reactome",eTerm = HT_Reactome$O3_vs_Air, top_num = 50, sortBy = 'adjp', decreasing = NULL, details = F)-> HTR
xEnrichViewer(tissue_mygo = "Liver_Reactome",eTerm = Liver_Reactome$O3_vs_Air, top_num = 50, sortBy = 'adjp', decreasing = NULL, details = F)-> LiverR
xEnrichViewer(tissue_mygo = "Lung_Reactome",eTerm = Lung_Reactome$O3_vs_Air, top_num = 50, sortBy = 'adjp', decreasing = NULL, details = F)-> LungR
xEnrichViewer(tissue_mygo = "Muscle_Reactome",eTerm = Muscle_Reactome$O3_vs_Air, top_num = 50, sortBy = 'adjp', decreasing = NULL, details = F)-> MuscleR
colnames(ADR)[2:ncol(ADR)] <- paste0("Adrenal_",colnames(ADR)[2:ncol(ADR)])
colnames(AdiR)[2:ncol(AdiR)] <- paste0("Adipose_",colnames(AdiR)[2:ncol(AdiR)])
colnames(HTR)[2:ncol(HTR)] <- paste0("HT_",colnames(HTR)[2:ncol(HTR)])
colnames(LiverR)[2:ncol(LiverR)] <- paste0("Liver_",colnames(LiverR)[2:ncol(LiverR)])
colnames(LungR)[2:ncol(LungR)] <- paste0("Lung_",colnames(LungR)[2:ncol(LungR)])
colnames(MuscleR)[2:ncol(MuscleR)] <- paste0("Muscle_",colnames(MuscleR)[2:ncol(MuscleR)])
ADR$Adrenal_PercentOverlap <- round((ADR$Adrenal_nOverlap/ADR$Adrenal_nAnno)*100,0)
AdiR$Adipose_PercentOverlap <- round((AdiR$Adipose_nOverlap/AdiR$Adipose_nAnno)*100)
HTR$HT_PercentOverlap <- round((HTR$HT_nOverlap/HTR$HT_nAnno)*100)
LiverR$Liver_PercentOverlap <- round((LiverR$Liver_nOverlap/LiverR$Liver_nAnno)*100)
LungR$Lung_PercentOverlap <- round((LungR$Lung_nOverlap/LungR$Lung_nAnno)*100)
MuscleR$Muscle_PercentOverlap <- round((MuscleR$Muscle_nOverlap/MuscleR$Muscle_nAnno)*100)
tissues <- list(ADR,AdiR,HTR,LiverR,LungR,MuscleR)
Reactome <- Reduce(function(x,y)full_join(x,y,by="name"), tissues)
colnames(Reactome) <- c("Pathway",colnames(Reactome)[2:ncol(Reactome)])
Reactome[,c(1,11,4,7,21,14,17,31,24,27,41,34,37,51,44,47,61,54,57)] -> ReactomeTable
save(ReactomeTable,file="../output_files/pathways/ReactomeTable.R")rm(list = setdiff(ls(), lsf.str()))
load(file="../output_files/pathways/ReactomeTable.R")
ReactomeTable[,c(1,14:16,8:10,2:4,11:13,5:7,17:19)] -> ReactomeTable
ReactomeTable %>% mutate(
Adrenal_adjp=format(round(Adrenal_adjp,2),nsmall=2,scientific=TRUE),
Adrenal_fc=format(round(Adrenal_fc,2),nsmall=2,scientific=TRUE),
Adipose_adjp=format(round(Adipose_adjp,2),nsmall=2,scientific=TRUE),
Adipose_fc=format(round(Adipose_fc,2),nsmall=2,scientific=TRUE),
Liver_adjp=format(round(Liver_adjp,2),nsmall=2,scientific=TRUE),
Liver_fc=format(round(Liver_fc,2),nsmall=2,scientific=TRUE),
Lung_adjp=format(round(Lung_adjp,2),nsmall=2,scientific=TRUE),
Lung_fc=format(round(Lung_fc,2),nsmall=2,scientific=TRUE),
HT_adjp=format(round(HT_adjp,2),nsmall=2,scientific=TRUE),
HT_fc=format(round(HT_fc,2),nsmall=2,scientific=TRUE),
Muscle_adjp=format(round(Muscle_adjp,2),nsmall=2,scientific=TRUE),
Muscle_fc=format(round(Muscle_fc,2),nsmall=2,scientific=TRUE)) %>%
kable(caption = "Supplementary Table 5. Tissue-specific enrichment of Reactome pathways after an acute ozone exposure", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>% column_spec(c(2:4),bold=ifelse(is.na(ReactomeTable$Adrenal_adjp),F,ifelse(ReactomeTable$Adrenal_adjp<.1,T,F)),color= ifelse(is.na(ReactomeTable$Adrenal_adjp),"gray",ifelse(ReactomeTable$Adrenal_adjp <.1,spec_color(ReactomeTable$Adrenal_fc,n=11,direction=-1,option='D'),"gray"))) %>% column_spec(c(5:7),bold=ifelse(is.na(ReactomeTable$Adipose_adjp),F,ifelse(ReactomeTable$Adipose_adjp<.1,T,F)),color= ifelse(is.na(ReactomeTable$Adipose_adjp),"gray",ifelse(ReactomeTable$Adipose_adjp <.1,spec_color(ReactomeTable$Adipose_fc,n=11,direction=-1,option='D'),"gray"))) %>% column_spec(c(8:10),bold=ifelse(is.na(ReactomeTable$HT_adjp),F,ifelse(ReactomeTable$HT_adjp<.1,T,F)),color= ifelse(is.na(ReactomeTable$HT_adjp),"gray",ifelse(ReactomeTable$HT_adjp <.1,spec_color(ReactomeTable$HT_fc,n=11,direction=-1,option='D'),"gray"))) %>% column_spec(c(11:13),bold=ifelse(is.na(ReactomeTable$Liver_adjp),F,ifelse(ReactomeTable$Liver_adjp<.1,T,F)),color= ifelse(is.na(ReactomeTable$Liver_adjp),"gray",ifelse(ReactomeTable$Liver_adjp <.1,spec_color(ReactomeTable$Liver_fc,n=11,direction=-1,option='D'),"gray"))) %>% column_spec(c(14:16),bold=ifelse(is.na(ReactomeTable$Lung_adjp),F,ifelse(ReactomeTable$Lung_adjp<.1,T,F)),color= ifelse(is.na(ReactomeTable$Lung_adjp),"gray",ifelse(ReactomeTable$Lung_adjp <.1,spec_color(ReactomeTable$Lung_fc,n=11,direction=-1,option='D'),"gray"))) %>% column_spec(c(17:19),bold=ifelse(is.na(ReactomeTable$Muscle_adjp),F,ifelse(ReactomeTable$Muscle_adjp<.1,T,F)),color= ifelse(is.na(ReactomeTable$Muscle_adjp),"gray",ifelse(ReactomeTable$Muscle_adjp <.1,spec_color(ReactomeTable$Muscle_fc,n=11,direction=-1,option='D'),"gray"))) %>% scroll_box(width = "1200px", height = "500px")| Pathway | Lung_PercentOverlap | Lung_fc | Lung_adjp | HT_PercentOverlap | HT_fc | HT_adjp | Adrenal_PercentOverlap | Adrenal_fc | Adrenal_adjp | Liver_PercentOverlap | Liver_fc | Liver_adjp | Adipose_PercentOverlap | Adipose_fc | Adipose_adjp | Muscle_PercentOverlap | Muscle_fc | Muscle_adjp |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Interferon gamma signaling | 21 | 2.36e+00 | 7.0e-02 | NA | NA | NA | 37 | 2.61e+00 | 4.0e-02 | 14 | 1.87e+00 | 3.3e-01 | 19 | 2.62e+00 | 6.0e-02 | 65 | 2.32e+00 | 0.0e+00 |
| Interferon alpha/beta signaling | 24 | 2.68e+00 | 3.0e-02 | NA | NA | NA | 36 | 2.51e+00 | 5.0e-02 | 19 | 2.56e+00 | 9.0e-02 | NA | NA | NA | 48 | 1.70e+00 | 9.0e-02 |
| Meiosis | NA | NA | NA | NA | NA | NA | 31 | 2.14e+00 | 8.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| tRNA Aminoacylation | NA | NA | NA | NA | NA | NA | 33 | 2.34e+00 | 8.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Regulation of IFNA signaling | NA | NA | NA | NA | NA | NA | 55 | 3.83e+00 | 9.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Double-Strand Break Repair | NA | NA | NA | NA | NA | NA | 38 | 2.67e+00 | 1.9e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Meiotic Recombination | NA | NA | NA | NA | NA | NA | 32 | 2.27e+00 | 1.9e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Hemostasis | 12 | 1.31e+00 | 1.3e-01 | NA | NA | NA | 19 | 1.32e+00 | 1.9e-01 | NA | NA | NA | NA | NA | NA | 38 | 1.35e+00 | 0.0e+00 |
| Basigin interactions | 26 | 2.94e+00 | 7.0e-02 | NA | NA | NA | 35 | 2.44e+00 | 2.4e-01 | NA | NA | NA | 22 | 3.06e+00 | 9.0e-02 | 57 | 2.01e+00 | 8.0e-02 |
| BMAL1:CLOCK/NPAS2 Activates Circadian Expression | 22 | 2.50e+00 | 7.0e-02 | NA | NA | NA | 31 | 2.15e+00 | 2.4e-01 | 31 | 4.10e+00 | 1.0e-02 | 28 | 3.91e+00 | 2.0e-02 | NA | NA | NA |
| Interferon Signaling | 14 | 1.58e+00 | 1.4e-01 | NA | NA | NA | 22 | 1.57e+00 | 2.4e-01 | 10 | 1.33e+00 | 5.4e-01 | NA | NA | NA | 38 | 1.35e+00 | 1.5e-01 |
| Cytosolic tRNA aminoacylation | NA | NA | NA | NA | NA | NA | 33 | 2.34e+00 | 2.8e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Growth hormone receptor signaling | NA | NA | NA | NA | NA | NA | 33 | 2.34e+00 | 3.7e-01 | 24 | 3.20e+00 | 1.1e-01 | NA | NA | NA | 57 | 2.03e+00 | 9.0e-02 |
| Cell surface interactions at the vascular wall | 17 | 1.90e+00 | 8.0e-02 | NA | NA | NA | 23 | 1.64e+00 | 3.7e-01 | 13 | 1.74e+00 | 2.5e-01 | 14 | 2.01e+00 | 9.0e-02 | 49 | 1.76e+00 | 0.0e+00 |
| Nitric oxide stimulates guanylate cyclase | NA | NA | NA | NA | NA | NA | 32 | 2.23e+00 | 4.4e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Processive synthesis on the lagging strand | NA | NA | NA | NA | NA | NA | 36 | 2.51e+00 | 4.5e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| G0 and Early G1 | NA | NA | NA | NA | NA | NA | 30 | 2.14e+00 | 4.5e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| E2F mediated regulation of DNA replication | NA | NA | NA | NA | NA | NA | 27 | 1.91e+00 | 4.5e-01 | 24 | 3.25e+00 | 5.0e-02 | NA | NA | NA | NA | NA | NA |
| Loss of Nlp from mitotic centrosomes | NA | NA | NA | NA | NA | NA | 24 | 1.69e+00 | 4.5e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Activation of the pre-replicative complex | NA | NA | NA | NA | NA | NA | 28 | 1.94e+00 | 4.5e-01 | 17 | 2.31e+00 | 2.5e-01 | NA | NA | NA | NA | NA | NA |
| G2/M Checkpoints | NA | NA | NA | NA | NA | NA | 26 | 1.80e+00 | 4.5e-01 | 15 | 2.07e+00 | 2.7e-01 | NA | NA | NA | NA | NA | NA |
| Recruitment of mitotic centrosome proteins and complexes | NA | NA | NA | NA | NA | NA | 23 | 1.61e+00 | 4.5e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| PPARA Activates Gene Expression | NA | NA | NA | NA | NA | NA | 21 | 1.47e+00 | 4.5e-01 | 16 | 2.15e+00 | 5.0e-02 | NA | NA | NA | NA | NA | NA |
| Nuclear Receptor transcription pathway | 16 | 1.75e+00 | 2.8e-01 | NA | NA | NA | 24 | 1.72e+00 | 4.6e-01 | 16 | 2.09e+00 | 2.3e-01 | 18 | 2.51e+00 | 7.0e-02 | NA | NA | NA |
| Circadian Clock | 19 | 2.17e+00 | 7.0e-02 | NA | NA | NA | 23 | 1.62e+00 | 5.0e-01 | 23 | 3.10e+00 | 2.0e-02 | 21 | 2.98e+00 | 2.0e-02 | NA | NA | NA |
| DNA Repair | NA | NA | NA | NA | NA | NA | 20 | 1.43e+00 | 5.0e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Integrin cell surface interactions | NA | NA | NA | NA | NA | NA | 21 | 1.50e+00 | 5.0e-01 | NA | NA | NA | NA | NA | NA | 49 | 1.76e+00 | 0.0e+00 |
| Mitotic G2-G2/M phases | NA | NA | NA | NA | NA | NA | 21 | 1.50e+00 | 5.0e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| TRAF6 mediated IRF7 activation | NA | NA | NA | NA | NA | NA | 31 | 2.19e+00 | 5.2e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Mitochondrial tRNA aminoacylation | NA | NA | NA | NA | NA | NA | 29 | 2.01e+00 | 5.2e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Global Genomic NER (GG-NER) | NA | NA | NA | NA | NA | NA | 25 | 1.76e+00 | 5.4e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Purine metabolism | NA | NA | NA | NA | NA | NA | 25 | 1.76e+00 | 5.4e-01 | NA | NA | NA | 16 | 2.20e+00 | 2.0e-01 | NA | NA | NA |
| cGMP effects | NA | NA | NA | NA | NA | NA | 29 | 2.06e+00 | 5.6e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | NA | NA | NA | NA | NA | NA | 29 | 2.06e+00 | 5.6e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Metabolism of nucleotides | NA | NA | NA | NA | NA | NA | 21 | 1.47e+00 | 5.8e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Cytokine Signaling in Immune system | 13 | 1.48e+00 | 9.0e-02 | NA | NA | NA | 18 | 1.24e+00 | 5.8e-01 | 10 | 1.34e+00 | 3.3e-01 | 13 | 1.79e+00 | 3.0e-02 | 37 | 1.32e+00 | 5.0e-02 |
| Lagging Strand Synthesis | NA | NA | NA | NA | NA | NA | 28 | 1.95e+00 | 6.0e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Activation of ATR in response to replication stress | NA | NA | NA | NA | NA | NA | 24 | 1.65e+00 | 6.0e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Cell Cycle | NA | NA | NA | 1 | 9.20e-01 | 6.3e-01 | 17 | 1.18e+00 | 6.0e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Generic Transcription Pathway | NA | NA | NA | NA | NA | NA | 18 | 1.29e+00 | 6.0e-01 | NA | NA | NA | 14 | 1.99e+00 | 3.0e-02 | NA | NA | NA |
| DNA strand elongation | NA | NA | NA | NA | NA | NA | 24 | 1.69e+00 | 6.1e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Base Excision Repair | NA | NA | NA | NA | NA | NA | 26 | 1.85e+00 | 6.4e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | NA | NA | NA | NA | NA | NA | 26 | 1.85e+00 | 6.4e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| RORA Activates Circadian Expression | NA | NA | NA | NA | NA | NA | 25 | 1.76e+00 | 6.4e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | NA | NA | NA | NA | NA | NA | 21 | 1.46e+00 | 6.4e-01 | NA | NA | NA | 19 | 2.66e+00 | 3.0e-02 | NA | NA | NA |
| Signaling by TGF-beta Receptor Complex | NA | NA | NA | NA | NA | NA | 20 | 1.40e+00 | 7.0e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Formation of incision complex in GG-NER | NA | NA | NA | NA | NA | NA | 25 | 1.76e+00 | 7.1e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | 18 | 2.00e+00 | 6.0e-02 | 6 | 4.11e+00 | 2.0e-02 | 19 | 1.33e+00 | 7.1e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Extension of Telomeres | NA | NA | NA | NA | NA | NA | 23 | 1.62e+00 | 7.3e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Chromosome Maintenance | NA | NA | NA | NA | NA | NA | 19 | 1.32e+00 | 7.3e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| FGFR ligand binding and activation | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 40 | 5.64e+00 | 2.0e-02 | NA | NA | NA |
| Other semaphorin interactions | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 40 | 5.64e+00 | 2.0e-02 | 60 | 2.14e+00 | 1.3e-01 |
| Negative regulation of FGFR signaling | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 28 | 3.89e+00 | 2.0e-02 | NA | NA | NA |
| Synthesis of PIPs at the plasma membrane | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 27 | 3.76e+00 | 2.0e-02 | NA | NA | NA |
| SHC-mediated cascade | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 29 | 4.03e+00 | 3.0e-02 | NA | NA | NA |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | NA | NA | NA | NA | NA | NA | NA | NA | NA | 19 | 2.56e+00 | 9.0e-02 | 21 | 3.02e+00 | 3.0e-02 | NA | NA | NA |
| Amino acid transport across the plasma membrane | 31 | 3.50e+00 | 1.0e-02 | NA | NA | NA | NA | NA | NA | 28 | 3.70e+00 | 3.0e-02 | 24 | 3.40e+00 | 3.0e-02 | NA | NA | NA |
| FRS2-mediated cascade | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 24 | 3.40e+00 | 3.0e-02 | NA | NA | NA |
| PI3K Cascade | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 19 | 2.63e+00 | 3.0e-02 | NA | NA | NA |
| Signaling by FGFR mutants | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 22 | 3.05e+00 | 3.0e-02 | NA | NA | NA |
| Signaling by Interleukins | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 15 | 2.14e+00 | 3.0e-02 | NA | NA | NA |
| Immune System | 11 | 1.21e+00 | 1.4e-01 | 3 | 1.79e+00 | 2.0e-02 | NA | NA | NA | 9 | 1.15e+00 | 4.3e-01 | 10 | 1.37e+00 | 3.0e-02 | NA | NA | NA |
| PI Metabolism | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 20 | 2.76e+00 | 3.0e-02 | NA | NA | NA |
| Amino acid and oligopeptide SLC transporters | 21 | 2.40e+00 | 5.0e-02 | NA | NA | NA | NA | NA | NA | 17 | 2.29e+00 | 1.4e-01 | 19 | 2.70e+00 | 4.0e-02 | NA | NA | NA |
| PI-3K cascade | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 19 | 2.70e+00 | 4.0e-02 | NA | NA | NA |
| Signaling by FGFR in disease | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 14 | 2.00e+00 | 4.0e-02 | NA | NA | NA |
| Innate Immune System | 12 | 1.36e+00 | 2.4e-01 | 5 | 3.26e+00 | 1.0e-02 | NA | NA | NA | NA | NA | NA | 12 | 1.70e+00 | 5.0e-02 | NA | NA | NA |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 24 | 3.36e+00 | 7.0e-02 | NA | NA | NA |
| Semaphorin interactions | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 16 | 2.20e+00 | 7.0e-02 | 44 | 1.56e+00 | 9.0e-02 |
| Signaling by BMP | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 23 | 3.20e+00 | 8.0e-02 | NA | NA | NA |
| Insulin receptor signalling cascade | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 15 | 2.07e+00 | 8.0e-02 | NA | NA | NA |
| Pyrimidine metabolism | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 22 | 3.06e+00 | 9.0e-02 | NA | NA | NA |
| Signaling by FGFR | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 13 | 1.85e+00 | 1.0e-01 | NA | NA | NA |
| Interleukin receptor SHC signaling | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 21 | 2.94e+00 | 1.0e-01 | NA | NA | NA |
| GPCR downstream signaling | 15 | 1.67e+00 | 0.0e+00 | 2 | 1.58e+00 | 1.4e-01 | NA | NA | NA | NA | NA | NA | 10 | 1.37e+00 | 1.1e-01 | NA | NA | NA |
| Phospholipase C-mediated cascade | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 16 | 2.24e+00 | 1.3e-01 | NA | NA | NA |
| Signaling by Insulin receptor | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 13 | 1.80e+00 | 1.3e-01 | NA | NA | NA |
| PI3K/AKT activation | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 17 | 2.35e+00 | 1.4e-01 | NA | NA | NA |
| Phospholipid metabolism | NA | NA | NA | 3 | 2.11e+00 | 9.0e-02 | NA | NA | NA | 11 | 1.45e+00 | 2.5e-01 | 11 | 1.52e+00 | 1.4e-01 | NA | NA | NA |
| NOD1/2 Signaling Pathway | NA | NA | NA | NA | NA | NA | NA | NA | NA | 17 | 2.31e+00 | 2.5e-01 | 17 | 2.43e+00 | 1.6e-01 | NA | NA | NA |
| Interleukin-1 signaling | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 16 | 2.23e+00 | 1.6e-01 | NA | NA | NA |
| Interleukin-2 signaling | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 16 | 2.23e+00 | 1.6e-01 | NA | NA | NA |
| Downstream signaling of activated FGFR | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 12 | 1.76e+00 | 1.6e-01 | NA | NA | NA |
| Transport of inorganic cations/anions and amino acids/oligopeptides | 17 | 1.90e+00 | 7.0e-02 | NA | NA | NA | NA | NA | NA | 13 | 1.81e+00 | 1.8e-01 | 12 | 1.74e+00 | 1.6e-01 | NA | NA | NA |
| G alpha (s) signalling events | 15 | 1.69e+00 | 1.2e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA | 12 | 1.69e+00 | 1.6e-01 | NA | NA | NA |
| Interleukin-3, 5 and GM-CSF signaling | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 15 | 2.17e+00 | 1.7e-01 | NA | NA | NA |
| Amine ligand-binding receptors | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 16 | 2.27e+00 | 1.8e-01 | NA | NA | NA |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 25 | 2.82e+00 | 2.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | 15 | 2.11e+00 | 1.8e-01 | NA | NA | NA |
| Class A/1 (Rhodopsin-like receptors) | 19 | 2.12e+00 | 0.0e+00 | 3 | 2.13e+00 | 6.0e-02 | NA | NA | NA | NA | NA | NA | 10 | 1.39e+00 | 1.8e-01 | NA | NA | NA |
| Signaling by GPCR | 15 | 1.71e+00 | 0.0e+00 | 3 | 1.90e+00 | 3.0e-02 | NA | NA | NA | NA | NA | NA | 9 | 1.26e+00 | 1.8e-01 | 33 | 1.17e+00 | 1.2e-01 |
| Toll Receptor Cascades | NA | NA | NA | 7 | 4.25e+00 | 1.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| MyD88:Mal cascade initiated on plasma membrane | NA | NA | NA | 7 | 4.33e+00 | 2.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| G alpha (i) signalling events | 15 | 1.70e+00 | 5.0e-02 | 5 | 3.13e+00 | 2.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| GPCR ligand binding | 19 | 2.09e+00 | 0.0e+00 | 4 | 2.33e+00 | 2.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Activated TLR4 signalling | NA | NA | NA | 6 | 3.86e+00 | 3.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| SLC-mediated transmembrane transport | 15 | 1.72e+00 | 1.0e-02 | 4 | 2.33e+00 | 5.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Peptide ligand-binding receptors | 19 | 2.11e+00 | 0.0e+00 | 4 | 2.51e+00 | 6.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Signaling by the B Cell Receptor (BCR) | NA | NA | NA | 4 | 2.70e+00 | 6.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Transmembrane transport of small molecules | 12 | 1.38e+00 | 8.0e-02 | 3 | 1.73e+00 | 9.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Fatty acid, triacylglycerol, and ketone body metabolism | NA | NA | NA | 3 | 1.98e+00 | 1.4e-01 | NA | NA | NA | 13 | 1.72e+00 | 9.0e-02 | NA | NA | NA | NA | NA | NA |
| Metabolism of lipids and lipoproteins | NA | NA | NA | 2 | 1.48e+00 | 1.7e-01 | NA | NA | NA | 11 | 1.50e+00 | 5.0e-02 | NA | NA | NA | NA | NA | NA |
| Adaptive Immune System | NA | NA | NA | 2 | 1.26e+00 | 3.1e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Metabolism of proteins | NA | NA | NA | 2 | 1.16e+00 | 4.2e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Phase II conjugation | NA | NA | NA | NA | NA | NA | NA | NA | NA | 22 | 3.01e+00 | 3.0e-02 | NA | NA | NA | NA | NA | NA |
| Biological oxidations | 16 | 1.81e+00 | 9.0e-02 | NA | NA | NA | NA | NA | NA | 18 | 2.47e+00 | 3.0e-02 | NA | NA | NA | NA | NA | NA |
| Metabolism of amino acids and derivatives | NA | NA | NA | NA | NA | NA | NA | NA | NA | 14 | 1.91e+00 | 3.0e-02 | NA | NA | NA | NA | NA | NA |
| Metabolism of polyamines | NA | NA | NA | NA | NA | NA | NA | NA | NA | 33 | 4.48e+00 | 5.0e-02 | NA | NA | NA | NA | NA | NA |
| Sulfur amino acid metabolism | NA | NA | NA | NA | NA | NA | NA | NA | NA | 27 | 3.66e+00 | 6.0e-02 | NA | NA | NA | NA | NA | NA |
| Activation of Genes by ATF4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | 26 | 3.50e+00 | 7.0e-02 | NA | NA | NA | NA | NA | NA |
| Regulation of beta-cell development | NA | NA | NA | NA | NA | NA | NA | NA | NA | 25 | 3.36e+00 | 8.0e-02 | NA | NA | NA | NA | NA | NA |
| Regulation of gene expression in beta cells | NA | NA | NA | NA | NA | NA | NA | NA | NA | 28 | 3.73e+00 | 9.0e-02 | NA | NA | NA | NA | NA | NA |
| PERK regulated gene expression | NA | NA | NA | NA | NA | NA | NA | NA | NA | 23 | 3.10e+00 | 9.0e-02 | NA | NA | NA | NA | NA | NA |
| Cholesterol biosynthesis | NA | NA | NA | NA | NA | NA | NA | NA | NA | 25 | 3.36e+00 | 1.0e-01 | NA | NA | NA | NA | NA | NA |
| Antigen Activates B Cell Receptor Leading to Generation of Second Messengers | 18 | 2.01e+00 | 2.8e-01 | NA | NA | NA | NA | NA | NA | 21 | 2.88e+00 | 1.1e-01 | NA | NA | NA | NA | NA | NA |
| Synthesis of PA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 21 | 2.80e+00 | 1.8e-01 | NA | NA | NA | 58 | 2.08e+00 | 4.0e-02 |
| G1 Phase | NA | NA | NA | NA | NA | NA | NA | NA | NA | 18 | 2.44e+00 | 1.8e-01 | NA | NA | NA | NA | NA | NA |
| Glycerophospholipid biosynthesis | NA | NA | NA | NA | NA | NA | NA | NA | NA | 14 | 1.87e+00 | 1.8e-01 | NA | NA | NA | NA | NA | NA |
| Glucose metabolism | NA | NA | NA | NA | NA | NA | NA | NA | NA | 15 | 1.98e+00 | 1.9e-01 | NA | NA | NA | 44 | 1.58e+00 | 9.0e-02 |
| Glycolysis | NA | NA | NA | NA | NA | NA | NA | NA | NA | 19 | 2.49e+00 | 2.3e-01 | NA | NA | NA | NA | NA | NA |
| Signaling by Rho GTPases | NA | NA | NA | NA | NA | NA | NA | NA | NA | 12 | 1.60e+00 | 2.5e-01 | NA | NA | NA | 38 | 1.34e+00 | 2.1e-01 |
| Sphingolipid de novo biosynthesis | 17 | 1.88e+00 | 3.2e-01 | NA | NA | NA | NA | NA | NA | 17 | 2.24e+00 | 2.7e-01 | NA | NA | NA | NA | NA | NA |
| Metabolism of vitamins and cofactors | NA | NA | NA | NA | NA | NA | NA | NA | NA | 14 | 1.88e+00 | 2.9e-01 | NA | NA | NA | NA | NA | NA |
| Unfolded Protein Response | NA | NA | NA | NA | NA | NA | NA | NA | NA | 12 | 1.68e+00 | 3.2e-01 | NA | NA | NA | NA | NA | NA |
| G1/S Transition | NA | NA | NA | NA | NA | NA | NA | NA | NA | 11 | 1.53e+00 | 3.2e-01 | NA | NA | NA | NA | NA | NA |
| Mitotic G1-G1/S phases | NA | NA | NA | NA | NA | NA | NA | NA | NA | 11 | 1.48e+00 | 3.2e-01 | NA | NA | NA | NA | NA | NA |
| Cell-Cell communication | NA | NA | NA | NA | NA | NA | NA | NA | NA | 11 | 1.43e+00 | 4.3e-01 | NA | NA | NA | NA | NA | NA |
| Metabolism of carbohydrates | NA | NA | NA | NA | NA | NA | NA | NA | NA | 10 | 1.29e+00 | 4.3e-01 | NA | NA | NA | 39 | 1.40e+00 | 1.0e-02 |
| MAP kinase activation in TLR cascade | NA | NA | NA | NA | NA | NA | NA | NA | NA | 12 | 1.64e+00 | 4.7e-01 | NA | NA | NA | NA | NA | NA |
| Phase 1 - Functionalization of compounds | 23 | 2.60e+00 | 5.0e-02 | NA | NA | NA | NA | NA | NA | 13 | 1.72e+00 | 4.7e-01 | NA | NA | NA | NA | NA | NA |
| S Phase | NA | NA | NA | NA | NA | NA | NA | NA | NA | 10 | 1.41e+00 | 4.7e-01 | NA | NA | NA | NA | NA | NA |
| PI3K events in ERBB2 signaling | NA | NA | NA | NA | NA | NA | NA | NA | NA | 12 | 1.60e+00 | 5.6e-01 | NA | NA | NA | NA | NA | NA |
| Chemokine receptors bind chemokines | 40 | 4.55e+00 | 0.0e+00 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Potassium Channels | 24 | 2.67e+00 | 0.0e+00 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Bile acid and bile salt metabolism | 36 | 4.10e+00 | 1.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Voltage gated Potassium channels | 27 | 3.02e+00 | 1.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Class B/2 (Secretin family receptors) | 21 | 2.34e+00 | 1.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 43 | 1.53e+00 | 8.0e-02 |
| Neuronal System | 14 | 1.57e+00 | 3.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Nucleotide-like (purinergic) receptors | 33 | 3.76e+00 | 5.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Synthesis of bile acids and bile salts | 29 | 3.31e+00 | 7.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Response to elevated platelet cytosolic Ca2+ | 17 | 1.88e+00 | 9.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 50 | 1.78e+00 | 0.0e+00 |
| Degradation of the extracellular matrix | 26 | 2.96e+00 | 9.0e-02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Transport of vitamins, nucleosides, and related molecules | 21 | 2.41e+00 | 1.3e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| G alpha (q) signalling events | 13 | 1.50e+00 | 1.4e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Cytochrome P450 - arranged by substrate type | 21 | 2.35e+00 | 1.9e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Gastrin-CREB signalling pathway via PKC and MAPK | 12 | 1.38e+00 | 2.4e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Integrin alphaIIb beta3 signaling | 19 | 2.09e+00 | 2.7e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Intrinsic Pathway for Apoptosis | 18 | 2.01e+00 | 2.8e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| O-linked glycosylation of mucins | 16 | 1.79e+00 | 2.8e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| GABA B receptor activation | 16 | 1.83e+00 | 2.9e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Inwardly rectifying K+ channels | 17 | 1.88e+00 | 3.2e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Formation of Fibrin Clot (Clotting Cascade) | 16 | 1.82e+00 | 3.5e-01 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Muscle contraction | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 64 | 2.29e+00 | 0.0e+00 |
| Striated Muscle Contraction | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 74 | 2.64e+00 | 0.0e+00 |
| Platelet activation, signaling and aggregation | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 43 | 1.54e+00 | 0.0e+00 |
| Axon guidance | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 42 | 1.48e+00 | 0.0e+00 |
| Extracellular matrix organization | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 51 | 1.83e+00 | 0.0e+00 |
| Collagen formation | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 55 | 1.94e+00 | 0.0e+00 |
| Developmental Biology | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 36 | 1.30e+00 | 1.0e-02 |
| Chondroitin sulfate biosynthesis | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 68 | 2.44e+00 | 1.0e-02 |
| Chondroitin sulfate/dermatan sulfate metabolism | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 53 | 1.90e+00 | 1.0e-02 |
| Glycosaminoglycan metabolism | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 44 | 1.56e+00 | 1.0e-02 |
| Glycogen breakdown (glycogenolysis) | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 71 | 2.54e+00 | 3.0e-02 |
| L1CAM interactions | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 44 | 1.56e+00 | 4.0e-02 |
| Interaction between L1 and Ankyrins | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 60 | 2.14e+00 | 6.0e-02 |
| Ras activation uopn Ca2+ infux through NMDA receptor | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 62 | 2.23e+00 | 8.0e-02 |
| G alpha (12/13) signalling events | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 43 | 1.53e+00 | 8.0e-02 |
| NCAM signaling for neurite out-growth | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 44 | 1.55e+00 | 1.0e-01 |
| Interleukin-7 signaling | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 70 | 2.49e+00 | 1.1e-01 |
| NCAM1 interactions | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 47 | 1.69e+00 | 1.2e-01 |
| A tetrasaccharide linker sequence is required for GAG synthesis | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 52 | 1.86e+00 | 1.6e-01 |
| Platelet Adhesion to exposed collagen | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 64 | 2.27e+00 | 1.8e-01 |
| Regulation of Complement cascade | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 64 | 2.27e+00 | 1.8e-01 |
| CREB phosphorylation through the activation of CaMKII | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 57 | 2.03e+00 | 2.1e-01 |
| Inflammasomes | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 57 | 2.03e+00 | 2.1e-01 |
| Synthesis of very long-chain fatty acyl-CoAs | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 57 | 2.03e+00 | 2.1e-01 |
| Signaling by FGFR1 mutants | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 50 | 1.78e+00 | 2.1e-01 |
| NRAGE signals death through JNK | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 44 | 1.57e+00 | 2.1e-01 |
| Netrin-1 signaling | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 45 | 1.59e+00 | 2.1e-01 |
| Triglyceride Biosynthesis | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 45 | 1.59e+00 | 2.1e-01 |
| Smooth Muscle Contraction | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 50 | 1.78e+00 | 2.3e-01 |
| GPVI-mediated activation cascade | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 47 | 1.66e+00 | 2.3e-01 |
| Transport to the Golgi and subsequent modification | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 45 | 1.62e+00 | 2.3e-01 |
| CS/DS degradation | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 58 | 2.08e+00 | 2.5e-01 |
ReactomeTable %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table 5. Tissue-specific enrichment of Reactome pathways after an acute ozone exposure - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))rm(list = setdiff(ls(), lsf.str()))
## Load in data generated in the Curation.Rmd file found in the same src folder
## Load in transcriptomic data for each tissue
load("../output_files/Tissue/Adrenal/Adrenal_o3vAir.R")
load("../output_files/Tissue/Adrenal/Adipose_o3vAir.R")
load("../output_files/Tissue/Adrenal/HT_o3vAir.R")
load("../output_files/Tissue/Adrenal/Liver_o3vAir.R")
load("../output_files/Tissue/Adrenal/Lung_o3vAir.R")
load("../output_files/Tissue/Adrenal/Muscle_o3vAir.R")
twj_tissue.format(AD1,"AD") -> AD.t
twj_tissue.format(HT1,"HT") -> HT.t
twj_tissue.format(Liver1,"Liver") -> Liver.t
twj_tissue.format(Lung1,"Lung") -> Lung.t
twj_tissue.format(Adi1,"Adi") -> Adi.t
twj_tissue.format(Musc1,"Musc") -> Musc.t
## Load in metabolomic data and annotation file
load(file = "../output_files/Tissue/Metabo/Metabo_results.R")
read_excel("../input_files/chemicalannotation.xlsx") -> Met.analytes
colnames(Met.analytes)[colnames(Met.analytes) == 'CHEMICAL_NAME'] <- 'metabolite'
merge(Contrasts,Met.analytes,by="metabolite") -> MET
MET[,c(17,2,3)] -> MET
colnames(MET) <- c("HMDB","logFC","pValue")
as.numeric(MET$logFC) -> MET$logFC
as.numeric(MET$pValue) -> MET$pValue
# create data structure
omics_data <- initOmicsDataStructure( layer = c("transcriptome", "metabolome"))
library(org.Hs.eg.db)
twj_multiGSEA(transcriptome = AD.t, databases = c("kegg","reactome")) -> ADMet
twj_multiGSEA(transcriptome = HT.t, databases = c("kegg","reactome")) -> HTMet
twj_multiGSEA(transcriptome = Liver.t, databases = c("kegg","reactome")) -> LiverMet
twj_multiGSEA(transcriptome = Lung.t, databases = c("kegg","reactome")) -> LungMet
twj_multiGSEA(transcriptome = Adi.t, databases = c("kegg","reactome")) -> AdiMet
twj_multiGSEA(transcriptome = Musc.t, databases = c("kegg","reactome")) -> MuscleMet
colnames(ADMet) <- c("Pathway","Adrenal_transcriptome_pval","Adrenal_transcriptome_padj","Adrenal_Metabolome_pval","Adrenal_Metabolome_padj","Adrenal_Combined_pval")
colnames(AdiMet) <- c("Pathway","Adipose_transcriptome_pval","Adipose_transcriptome_padj","Adipose_Metabolome_pval","Adipose_Metabolome_padj","Adipose_Combined_pval")
colnames(HTMet) <- c("Pathway","HT_transcriptome_pval","HT_transcriptome_padj","HT_Metabolome_pval","HT_Metabolome_padj","HT_Combined_pval")
colnames(LiverMet) <- c("Pathway","Liver_transcriptome_pval","Liver_transcriptome_padj","Liver_Metabolome_pval","Liver_Metabolome_padj","Liver_Combined_pval")
colnames(LungMet) <- c("Pathway","Lung_transcriptome_pval","Lung_transcriptome_padj","Lung_Metabolome_pval","Lung_Metabolome_padj","Lung_Combined_pval")
colnames(MuscleMet) <- c("Pathway","Muscle_transcriptome_pval","Muscle_transcriptome_padj","Muscle_Metabolome_pval","Muscle_Metabolome_padj","Muscle_Combined_pval")
plyr::join_all(list(ADMet,HTMet,LiverMet,LungMet,AdiMet,MuscleMet)) -> Combined_TransMet
save(Combined_TransMet,file="../output_files/pathways/TranscriptomicMetabolomicCombined.R")rm(list = setdiff(ls(), lsf.str()))
load(file = "../output_files/pathways/TranscriptomicMetabolomicCombined.R")
Combined_TransMet %>% dplyr::filter(grepl("KEGG",Pathway)) -> KEGG
KEGG[,c(1,21,11,6,16,26,31)] -> KEGGTable
KEGGTable[order(KEGGTable$Lung_Combined_pval),] -> KEGGTable
KEGGTable %>%
mutate(
Lung_Combined_pval=format(round(Lung_Combined_pval,2),nsmall=2,scientific=TRUE),
HT_Combined_pval=format(round(HT_Combined_pval,2),nsmall=2,scientific=TRUE),
Adrenal_Combined_pval=format(round(Adrenal_Combined_pval,2),nsmall=2,scientific=TRUE),
Liver_Combined_pval=format(round(Liver_Combined_pval,2),nsmall=2,scientific=TRUE),
Adipose_Combined_pval=format(round(Adipose_Combined_pval,2),nsmall=2,scientific=TRUE),
Muscle_Combined_pval=format(round(Muscle_Combined_pval,2),nsmall=2,scientific=TRUE)) %>%
kable(caption = "Supplementary Table 6. Integrated transcriptomic and metabolomic KEGG pathway analysis", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(5,bold=ifelse(is.na(KEGGTable$Adrenal_Combined_pval),F,ifelse(KEGGTable$Adrenal_Combined_pval<.1,T,F)),color= ifelse(is.na(KEGGTable$Adrenal_Combined_pval),"gray",ifelse(KEGGTable$Adrenal_Combined_pval <.1,"#fdc4ad","gray"))) %>%
column_spec(4,bold=ifelse(is.na(KEGGTable$HT_Combined_pval),F,ifelse(KEGGTable$HT_Combined_pval<.1,T,F)),color= ifelse(is.na(KEGGTable$HT_Combined_pval),"gray",ifelse(KEGGTable$HT_Combined_pval <.1,"#c2cce3","gray"))) %>%
column_spec(6,bold=ifelse(is.na(KEGGTable$Liver_Combined_pval),F,ifelse(KEGGTable$Liver_Combined_pval<.1,T,F)),color= ifelse(is.na(KEGGTable$Liver_Combined_pval),"gray",ifelse(KEGGTable$Liver_Combined_pval <.1,"#f0b4d9","gray"))) %>%
column_spec(3,bold=ifelse(is.na(KEGGTable$Lung_Combined_pval),F,ifelse(KEGGTable$Lung_Combined_pval<.1,T,F)),color= ifelse(is.na(KEGGTable$Lung_Combined_pval),"gray",ifelse(KEGGTable$Lung_Combined_pval <.1,"#c6e692","gray"))) %>%
column_spec(7,bold=ifelse(is.na(KEGGTable$Adipose_Combined_pval),F,ifelse(KEGGTable$Adipose_Combined_pval<.1,T,F)),color= ifelse(is.na(KEGGTable$Adipose_Combined_pval),"gray",ifelse(KEGGTable$Adipose_Combined_pval <.1,"#9dd8c5","gray"))) %>%
column_spec(8,bold=ifelse(is.na(KEGGTable$Muscle_Combined_pval),F,ifelse(KEGGTable$Muscle_Combined_pval<.1,T,F)),color= ifelse(is.na(KEGGTable$Muscle_Combined_pval),"gray",ifelse(KEGGTable$Muscle_Combined_pval <.1,"#e0b880","gray"))) %>%
scroll_box(width = "1200px", height = "500px")| Pathway | Lung_Combined_pval | HT_Combined_pval | Adrenal_Combined_pval | Liver_Combined_pval | Adipose_Combined_pval | Muscle_Combined_pval | |
|---|---|---|---|---|---|---|---|
| 300 | (KEGG) Small cell lung cancer | 0.0e+00 | 6.4e-01 | 8.5e-01 | 8.5e-01 | 6.1e-01 | 6.8e-01 |
| 110 | (KEGG) HIF-1 signaling pathway | 3.0e-02 | 3.1e-01 | 8.8e-01 | 3.4e-01 | 1.5e-01 | 3.6e-01 |
| 118 | (KEGG) p53 signaling pathway | 4.0e-02 | 4.4e-01 | 8.9e-01 | 8.5e-01 | 9.0e-02 | 6.6e-01 |
| 129 | (KEGG) PI3K-Akt signaling pathway | 4.0e-02 | 2.2e-01 | 6.0e-01 | 9.6e-01 | 6.1e-01 | 2.0e-02 |
| 255 | (KEGG) Shigellosis | 4.0e-02 | 9.4e-01 | 6.4e-01 | 8.8e-01 | 5.3e-01 | 2.1e-01 |
| 298 | (KEGG) Chronic myeloid leukemia | 4.0e-02 | 4.6e-01 | 9.6e-01 | 9.0e-01 | 4.9e-01 | 4.3e-01 |
| 92 | (KEGG) Platinum drug resistance | 4.0e-02 | 3.3e-01 | 9.4e-01 | 7.8e-01 | 4.5e-01 | 4.3e-01 |
| 288 | (KEGG) Colorectal cancer | 4.0e-02 | 5.9e-01 | 8.9e-01 | 8.5e-01 | 6.1e-01 | 6.3e-01 |
| 100 | (KEGG) ErbB signaling pathway | 5.0e-02 | 4.7e-01 | 9.7e-01 | 7.8e-01 | 6.4e-01 | 1.7e-01 |
| 280 | (KEGG) Pathways in cancer | 5.0e-02 | 0.0e+00 | 7.8e-01 | 9.8e-01 | 1.7e-01 | 3.0e-01 |
| 122 | (KEGG) Mitophagy - animal | 6.0e-02 | 6.4e-01 | 9.5e-01 | 8.8e-01 | 4.2e-01 | 7.0e-02 |
| 303 | (KEGG) Hepatocellular carcinoma | 7.0e-02 | 7.4e-01 | 8.7e-01 | 9.3e-01 | 8.6e-01 | 5.2e-01 |
| 123 | (KEGG) Autophagy - animal | 8.0e-02 | 9.9e-01 | 9.6e-01 | 7.8e-01 | 7.3e-01 | 3.0e-02 |
| 294 | (KEGG) Thyroid cancer | 8.0e-02 | 4.4e-01 | 9.1e-01 | 8.5e-01 | 5.2e-01 | 5.2e-01 |
| 271 | (KEGG) Human cytomegalovirus infection | 9.0e-02 | 4.8e-01 | 6.2e-01 | 9.4e-01 | 8.3e-01 | 5.5e-01 |
| 109 | (KEGG) NF-kappa B signaling pathway | 9.0e-02 | 5.2e-01 | 9.1e-01 | 9.5e-01 | 6.9e-01 | 3.4e-01 |
| 116 | (KEGG) Cell cycle | 9.0e-02 | 4.7e-01 | 9.6e-01 | 8.6e-01 | 2.8e-01 | 7.1e-01 |
| 216 | (KEGG) Parathyroid hormone synthesis, secretion and action | 9.0e-02 | 7.0e-01 | 6.5e-01 | 8.5e-01 | 7.3e-01 | 4.7e-01 |
| 258 | (KEGG) Legionellosis | 9.0e-02 | 7.1e-01 | 8.3e-01 | 9.7e-01 | 6.7e-01 | 3.6e-01 |
| 290 | (KEGG) Pancreatic cancer | 9.0e-02 | 5.6e-01 | 6.3e-01 | 8.7e-01 | 5.2e-01 | 7.1e-01 |
| 113 | (KEGG) Sphingolipid signaling pathway | 9.0e-02 | 9.6e-01 | 9.3e-01 | 9.0e-01 | 9.2e-01 | 9.2e-01 |
| 168 | (KEGG) JAK-STAT signaling pathway | 1.0e-01 | 6.4e-01 | 8.2e-01 | 9.4e-01 | 6.7e-01 | 4.3e-01 |
| 257 | (KEGG) Pertussis | 1.1e-01 | 4.0e-01 | 7.1e-01 | 8.1e-01 | 6.4e-01 | 3.1e-01 |
| 272 | (KEGG) Influenza A | 1.1e-01 | 9.0e-02 | 6.0e-01 | 6.3e-01 | 1.7e-01 | 2.8e-01 |
| 291 | (KEGG) Endometrial cancer | 1.1e-01 | 5.1e-01 | 9.0e-01 | 8.5e-01 | 6.5e-01 | 3.6e-01 |
| 99 | (KEGG) MAPK signaling pathway | 1.1e-01 | 1.5e-01 | 9.9e-01 | 8.6e-01 | 8.7e-01 | 6.7e-01 |
| 39 | (KEGG) Mucin type O-glycan biosynthesis | 1.1e-01 | 8.1e-01 | 6.0e-01 | 9.1e-01 | 9.8e-01 | 5.6e-01 |
| 301 | (KEGG) Non-small cell lung cancer | 1.1e-01 | 4.4e-01 | 9.4e-01 | 7.8e-01 | 7.4e-01 | 3.1e-01 |
| 297 | (KEGG) Bladder cancer | 1.2e-01 | 5.6e-01 | 9.2e-01 | 8.5e-01 | 5.2e-01 | 5.1e-01 |
| 224 | (KEGG) Alcoholic liver disease | 1.3e-01 | 1.2e-01 | 6.4e-01 | 9.4e-01 | 2.8e-01 | 4.3e-01 |
| 275 | (KEGG) Kaposi sarcoma-associated herpesvirus infection | 1.3e-01 | 5.1e-01 | 8.5e-01 | 9.0e-01 | 3.7e-01 | 3.1e-01 |
| 237 | (KEGG) Vitamin digestion and absorption | 1.3e-01 | 5.2e-01 | 8.3e-01 | NA | 5.2e-01 | 7.0e-01 |
| 293 | (KEGG) Prostate cancer | 1.4e-01 | 7.2e-01 | 6.0e-01 | 8.5e-01 | 6.8e-01 | 3.5e-01 |
| 152 | (KEGG) ECM-receptor interaction | 1.4e-01 | 7.0e-02 | 6.0e-01 | 9.4e-01 | 6.1e-01 | 0.0e+00 |
| 36 | (KEGG) Glutathione metabolism | 1.4e-01 | 4.4e-01 | 6.0e-01 | 9.4e-01 | 6.1e-01 | 1.8e-01 |
| 243 | (KEGG) Huntington disease | 1.4e-01 | 4.3e-01 | 6.0e-01 | 8.5e-01 | 2.5e-01 | 2.1e-01 |
| 264 | (KEGG) Toxoplasmosis | 1.4e-01 | 3.8e-01 | 7.8e-01 | 9.2e-01 | 9.6e-01 | 5.5e-01 |
| 180 | (KEGG) Circadian rhythm | 1.6e-01 | 6.1e-01 | 6.5e-01 | 9.4e-01 | 5.6e-01 | 3.8e-01 |
| 131 | (KEGG) Apoptosis | 1.6e-01 | 9.4e-01 | 8.6e-01 | 9.5e-01 | 7.2e-01 | 6.3e-01 |
| 164 | (KEGG) NOD-like receptor signaling pathway | 1.6e-01 | 2.5e-01 | 9.6e-01 | 9.7e-01 | 2.7e-01 | 6.9e-01 |
| 208 | (KEGG) Adipocytokine signaling pathway | 1.6e-01 | 1.9e-01 | 9.7e-01 | 8.7e-01 | 8.5e-01 | 7.0e-01 |
| 143 | (KEGG) Hedgehog signaling pathway | 1.6e-01 | 0.0e+00 | 7.3e-01 | 9.1e-01 | 7.8e-01 | 4.3e-01 |
| 134 | (KEGG) Apoptosis - multiple species | 1.7e-01 | 9.1e-01 | 9.4e-01 | 9.6e-01 | 8.4e-01 | 9.0e-01 |
| 81 | (KEGG) Metabolic pathways | 1.7e-01 | 5.0e-02 | 3.2e-01 | 2.1e-01 | 3.6e-01 | 4.2e-01 |
| 137 | (KEGG) Cellular senescence | 1.7e-01 | 8.8e-01 | 9.6e-01 | 8.6e-01 | 7.6e-01 | 7.0e-02 |
| 242 | (KEGG) Amyotrophic lateral sclerosis | 1.7e-01 | 0.0e+00 | 6.0e-01 | 9.1e-01 | 1.7e-01 | 0.0e+00 |
| 273 | (KEGG) Human papillomavirus infection | 1.7e-01 | 1.9e-01 | 6.0e-01 | 9.4e-01 | 4.6e-01 | 2.3e-01 |
| 220 | (KEGG) Non-alcoholic fatty liver disease | 1.9e-01 | 6.7e-01 | 9.6e-01 | 9.6e-01 | 6.8e-01 | 5.5e-01 |
| 274 | (KEGG) Human T-cell leukemia virus 1 infection | 1.9e-01 | 5.7e-01 | 7.9e-01 | 9.6e-01 | 5.2e-01 | 8.0e-01 |
| 154 | (KEGG) Adherens junction | 1.9e-01 | 4.5e-01 | 6.0e-01 | 9.6e-01 | 9.2e-01 | 6.2e-01 |
| 292 | (KEGG) Glioma | 1.9e-01 | 4.6e-01 | 9.6e-01 | 8.4e-01 | 8.0e-01 | 3.7e-01 |
| 54 | (KEGG) Sphingolipid metabolism | 1.9e-01 | 8.1e-01 | 8.7e-01 | 8.5e-01 | 3.3e-01 | 3.6e-01 |
| 179 | (KEGG) Intestinal immune network for IgA production | 2.4e-01 | 8.0e-02 | 8.3e-01 | 9.4e-01 | 3.7e-01 | 6.3e-01 |
| 212 | (KEGG) Renin secretion | 2.4e-01 | 8.9e-01 | 8.5e-01 | 9.3e-01 | 6.9e-01 | 4.4e-01 |
| 247 | (KEGG) Cocaine addiction | 2.4e-01 | 8.1e-01 | 6.0e-01 | 8.5e-01 | 8.5e-01 | 1.7e-01 |
| 261 | (KEGG) Chagas disease | 2.4e-01 | 8.1e-01 | 9.9e-01 | 9.4e-01 | 2.6e-01 | 6.3e-01 |
| 169 | (KEGG) Natural killer cell mediated cytotoxicity | 2.4e-01 | 9.1e-01 | 6.0e-01 | 9.1e-01 | 4.1e-01 | 4.3e-01 |
| 64 | (KEGG) Riboflavin metabolism | 2.4e-01 | 1.2e-01 | 9.9e-01 | 9.8e-01 | 9.5e-01 | 3.6e-01 |
| 160 | (KEGG) Antigen processing and presentation | 2.5e-01 | 6.5e-01 | 8.6e-01 | 7.8e-01 | 5.9e-01 | 2.4e-01 |
| 296 | (KEGG) Melanoma | 2.5e-01 | 5.8e-01 | 9.1e-01 | 8.5e-01 | 6.4e-01 | 4.8e-01 |
| 145 | (KEGG) Axon guidance | 2.6e-01 | 0.0e+00 | 6.2e-01 | 9.5e-01 | 3.2e-01 | 9.0e-02 |
| 321 | (KEGG) Fluid shear stress and atherosclerosis | 2.6e-01 | 8.3e-01 | 8.5e-01 | 9.9e-01 | 6.5e-01 | 4.2e-01 |
| 285 | (KEGG) MicroRNAs in cancer | 2.6e-01 | 5.4e-01 | 6.0e-01 | 7.8e-01 | 6.4e-01 | 1.4e-01 |
| 241 | (KEGG) Parkinson disease | 2.8e-01 | 0.0e+00 | 5.2e-01 | 9.0e-01 | 1.7e-01 | 3.0e-02 |
| 302 | (KEGG) Breast cancer | 2.9e-01 | 4.4e-01 | 7.0e-01 | 8.9e-01 | 5.2e-01 | 6.2e-01 |
| 153 | (KEGG) Cell adhesion molecules | 2.9e-01 | 5.1e-01 | 7.3e-01 | 9.5e-01 | 5.1e-01 | 1.0e-02 |
| 170 | (KEGG) IL-17 signaling pathway | 2.9e-01 | 6.3e-01 | 9.8e-01 | 9.4e-01 | 6.9e-01 | 8.1e-01 |
| 278 | (KEGG) Human immunodeficiency virus 1 infection | 2.9e-01 | 6.1e-01 | 6.0e-01 | 9.9e-01 | 6.4e-01 | 9.1e-01 |
| 189 | (KEGG) Serotonergic synapse | 3.1e-01 | 8.5e-01 | 9.5e-01 | 9.9e-01 | 9.8e-01 | 2.9e-01 |
| 94 | (KEGG) RNA degradation | 3.1e-01 | 1.0e+00 | 6.0e-01 | 9.4e-01 | 6.1e-01 | 6.0e-01 |
| 5 | (KEGG) Fructose and mannose metabolism | 3.1e-01 | 7.6e-01 | 6.0e-01 | 9.0e-01 | 6.6e-01 | 4.0e-02 |
| 74 | (KEGG) Nitrogen metabolism | 3.1e-01 | 5.1e-01 | 9.0e-01 | 8.5e-01 | 5.7e-01 | 2.2e-01 |
| 84 | (KEGG) Fatty acid metabolism | 3.1e-01 | 2.9e-01 | 7.3e-01 | 9.4e-01 | 9.6e-01 | 2.7e-01 |
| 253 | (KEGG) Epithelial cell signaling in Helicobacter pylori infection | 3.1e-01 | 6.4e-01 | 6.0e-01 | 8.5e-01 | 7.1e-01 | 6.6e-01 |
| 15 | (KEGG) Oxidative phosphorylation | 3.1e-01 | 3.7e-01 | 5.0e-01 | 8.2e-01 | 7.1e-01 | 8.9e-01 |
| 124 | (KEGG) Protein processing in endoplasmic reticulum | 3.1e-01 | 9.2e-01 | 6.0e-01 | 9.0e-01 | 2.5e-01 | 3.3e-01 |
| 147 | (KEGG) Apelin signaling pathway | 3.3e-01 | 2.0e-01 | 9.6e-01 | 9.1e-01 | 3.4e-01 | 7.2e-01 |
| 269 | (KEGG) Hepatitis B | 3.4e-01 | 4.3e-01 | 8.7e-01 | 8.7e-01 | 1.7e-01 | 7.3e-01 |
| 185 | (KEGG) Neurotrophin signaling pathway | 3.4e-01 | 9.2e-01 | 9.3e-01 | 9.6e-01 | 5.6e-01 | 7.0e-02 |
| 166 | (KEGG) Cytosolic DNA-sensing pathway | 3.4e-01 | 8.4e-01 | 6.0e-01 | 8.3e-01 | 1.7e-01 | 4.9e-01 |
| 305 | (KEGG) Central carbon metabolism in cancer | 3.4e-01 | 9.3e-01 | 6.0e-01 | 1.0e+00 | 4.9e-01 | 8.2e-01 |
| 158 | (KEGG) Complement and coagulation cascades | 3.4e-01 | 1.0e+00 | 8.6e-01 | 9.0e-01 | 0.0e+00 | 1.0e-02 |
| 111 | (KEGG) FoxO signaling pathway | 3.4e-01 | 5.3e-01 | 1.0e+00 | 7.8e-01 | 4.5e-01 | 3.0e-02 |
| 151 | (KEGG) Focal adhesion | 3.4e-01 | 0.0e+00 | 6.0e-01 | 1.0e+00 | 6.2e-01 | 0.0e+00 |
| 287 | (KEGG) Chemical carcinogenesis - reactive oxygen species | 3.4e-01 | 7.2e-01 | 9.2e-01 | 8.5e-01 | 6.2e-01 | 5.3e-01 |
| 177 | (KEGG) TNF signaling pathway | 3.4e-01 | 8.3e-01 | 8.3e-01 | 9.6e-01 | 8.1e-01 | 5.1e-01 |
| 90 | (KEGG) Endocrine resistance | 3.5e-01 | 5.2e-01 | 1.0e+00 | 9.0e-01 | 8.5e-01 | 5.9e-01 |
| 138 | (KEGG) Cardiac muscle contraction | 3.5e-01 | 3.3e-01 | 8.2e-01 | 9.4e-01 | 7.1e-01 | 9.2e-01 |
| 227 | (KEGG) Aldosterone-regulated sodium reabsorption | 3.5e-01 | 9.2e-01 | 6.0e-01 | 3.5e-01 | 5.9e-01 | 7.2e-01 |
| 28 | (KEGG) Phenylalanine metabolism | 3.5e-01 | 9.2e-01 | 9.2e-01 | 7.8e-01 | 8.1e-01 | 9.2e-01 |
| 98 | (KEGG) Fanconi anemia pathway | 3.5e-01 | 6.3e-01 | 6.0e-01 | 9.5e-01 | 8.4e-01 | 5.7e-01 |
| 51 | (KEGG) Arachidonic acid metabolism | 3.6e-01 | 5.0e-02 | 7.5e-01 | 8.5e-01 | 6.6e-01 | 2.3e-01 |
| 209 | (KEGG) Oxytocin signaling pathway | 3.6e-01 | 8.7e-01 | 9.2e-01 | 9.2e-01 | 9.4e-01 | 4.3e-01 |
| 8 | (KEGG) Fatty acid biosynthesis | 3.7e-01 | 1.7e-01 | 6.2e-01 | 1.0e+00 | 8.2e-01 | 8.2e-01 |
| 49 | (KEGG) Glycerophospholipid metabolism | 3.7e-01 | 4.0e-02 | 9.6e-01 | 7.8e-01 | 3.5e-01 | 3.1e-01 |
| 304 | (KEGG) Gastric cancer | 3.7e-01 | 4.7e-01 | 7.3e-01 | 8.7e-01 | 4.9e-01 | 5.7e-01 |
| 105 | (KEGG) cAMP signaling pathway | 3.7e-01 | 1.7e-01 | 8.2e-01 | 9.5e-01 | 5.3e-01 | 1.1e-01 |
| 45 | (KEGG) Glycosaminoglycan biosynthesis - heparan sulfate / heparin | 3.7e-01 | 9.5e-01 | 9.4e-01 | 9.1e-01 | 7.9e-01 | 9.8e-01 |
| 222 | (KEGG) Cushing syndrome | 3.7e-01 | 4.4e-01 | 6.0e-01 | 8.5e-01 | 4.4e-01 | 2.6e-01 |
| 43 | (KEGG) Glycosaminoglycan degradation | 3.7e-01 | 9.7e-01 | 6.0e-01 | 9.9e-01 | 9.4e-01 | 7.9e-01 |
| 104 | (KEGG) cGMP-PKG signaling pathway | 4.0e-01 | 4.8e-01 | 6.0e-01 | 9.4e-01 | 1.4e-01 | 2.6e-01 |
| 314 | (KEGG) Graft-versus-host disease | 4.0e-01 | 9.1e-01 | 8.7e-01 | 8.5e-01 | 6.5e-01 | 6.0e-01 |
| 262 | (KEGG) African trypanosomiasis | 4.0e-01 | 5.7e-01 | 9.1e-01 | 1.0e+00 | 9.9e-01 | 4.3e-01 |
| 268 | (KEGG) Hepatitis C | 4.1e-01 | 5.6e-01 | 7.1e-01 | 9.4e-01 | 5.4e-01 | 5.9e-01 |
| 141 | (KEGG) Wnt signaling pathway | 4.1e-01 | 4.0e-02 | 6.0e-01 | 9.4e-01 | 4.5e-01 | 5.0e-01 |
| 106 | (KEGG) Cytokine-cytokine receptor interaction | 4.1e-01 | 7.3e-01 | 8.1e-01 | 3.4e-01 | 3.8e-01 | 0.0e+00 |
| 284 | (KEGG) Proteoglycans in cancer | 4.2e-01 | 1.7e-01 | 6.0e-01 | 8.5e-01 | 6.5e-01 | 1.0e-01 |
| 16 | (KEGG) Arginine biosynthesis | 4.3e-01 | 6.7e-01 | 7.2e-01 | 3.9e-01 | 5.9e-01 | 2.2e-01 |
| 281 | (KEGG) Transcriptional misregulation in cancer | 4.3e-01 | 9.5e-01 | 9.6e-01 | 9.1e-01 | 4.5e-01 | 7.9e-01 |
| 315 | (KEGG) Hypertrophic cardiomyopathy | 4.3e-01 | 3.4e-01 | 9.6e-01 | 9.8e-01 | 9.7e-01 | 3.6e-01 |
| 53 | (KEGG) alpha-Linolenic acid metabolism | 4.4e-01 | 0.0e+00 | 9.5e-01 | 9.0e-01 | 8.4e-01 | 4.8e-01 |
| 295 | (KEGG) Basal cell carcinoma | 4.4e-01 | 4.3e-01 | 6.3e-01 | 8.2e-01 | 7.8e-01 | 7.9e-01 |
| 101 | (KEGG) Ras signaling pathway | 4.4e-01 | 5.2e-01 | 8.6e-01 | 1.0e+00 | 5.5e-01 | 2.2e-01 |
| 238 | (KEGG) Mineral absorption | 4.4e-01 | 3.8e-01 | 8.8e-01 | 8.5e-01 | 8.2e-01 | 8.6e-01 |
| 27 | (KEGG) Tyrosine metabolism | 4.5e-01 | 6.5e-01 | 6.4e-01 | 8.2e-01 | 9.9e-01 | 9.2e-01 |
| 240 | (KEGG) Alzheimer disease | 4.5e-01 | 3.5e-01 | 6.0e-01 | 9.5e-01 | 6.6e-01 | 2.6e-01 |
| 320 | (KEGG) Lipid and atherosclerosis | 4.5e-01 | 7.0e-02 | 9.6e-01 | 9.8e-01 | 2.5e-01 | 8.2e-01 |
| 312 | (KEGG) Rheumatoid arthritis | 4.5e-01 | 5.3e-01 | 8.8e-01 | 9.0e-01 | 6.1e-01 | 3.0e-01 |
| 89 | (KEGG) EGFR tyrosine kinase inhibitor resistance | 4.5e-01 | 4.8e-01 | 6.0e-01 | 9.4e-01 | 7.1e-01 | 4.4e-01 |
| 79 | (KEGG) Drug metabolism - other enzymes | 4.5e-01 | 4.6e-01 | 6.5e-01 | 9.4e-01 | 5.7e-01 | 7.9e-01 |
| 210 | (KEGG) Glucagon signaling pathway | 4.6e-01 | 9.8e-01 | 6.9e-01 | 8.5e-01 | 5.8e-01 | 1.0e-02 |
| 10 | (KEGG) Fatty acid degradation | 4.6e-01 | 1.4e-01 | 1.0e+00 | 8.7e-01 | 6.2e-01 | 8.0e-01 |
| 192 | (KEGG) Long-term depression | 4.7e-01 | 1.0e+00 | 9.1e-01 | 9.4e-01 | 8.5e-01 | 8.1e-01 |
| 34 | (KEGG) Selenocompound metabolism | 4.7e-01 | 6.2e-01 | 8.5e-01 | 7.8e-01 | 8.4e-01 | 9.8e-01 |
| 267 | (KEGG) Tuberculosis | 4.7e-01 | 9.4e-01 | 9.7e-01 | 9.6e-01 | 8.7e-01 | 7.3e-01 |
| 191 | (KEGG) Dopaminergic synapse | 4.7e-01 | 9.2e-01 | 6.0e-01 | 9.6e-01 | 9.7e-01 | 6.9e-01 |
| 246 | (KEGG) Pathways of neurodegeneration - multiple diseases | 4.8e-01 | 2.1e-01 | 6.0e-01 | 9.6e-01 | 6.9e-01 | 1.0e-02 |
| 26 | (KEGG) Histidine metabolism | 4.8e-01 | 9.2e-01 | 9.5e-01 | 9.9e-01 | 8.5e-01 | 7.0e-01 |
| 229 | (KEGG) Vasopressin-regulated water reabsorption | 4.8e-01 | 8.0e-01 | 6.0e-01 | 8.5e-01 | 4.5e-01 | 9.7e-01 |
| 313 | (KEGG) Allograft rejection | 4.8e-01 | 9.1e-01 | 8.9e-01 | 8.5e-01 | 7.8e-01 | 6.4e-01 |
| 149 | (KEGG) Hippo signaling pathway | 4.9e-01 | 6.0e-02 | 7.0e-01 | 8.5e-01 | 4.2e-01 | 3.7e-01 |
| 20 | (KEGG) Alanine, aspartate and glutamate metabolism | 4.9e-01 | 1.6e-01 | 7.9e-01 | 3.4e-01 | 2.7e-01 | 8.0e-02 |
| 250 | (KEGG) Alcoholism | 4.9e-01 | 9.5e-01 | 6.4e-01 | 9.1e-01 | 9.9e-01 | 6.5e-01 |
| 140 | (KEGG) Vascular smooth muscle contraction | 5.0e-01 | 1.6e-01 | 8.5e-01 | 9.7e-01 | 6.8e-01 | 3.6e-01 |
| 286 | (KEGG) Chemical carcinogenesis - receptor activation | 5.0e-01 | 4.0e-02 | 7.8e-01 | 9.8e-01 | 1.4e-01 | 1.7e-01 |
| 103 | (KEGG) Calcium signaling pathway | 5.1e-01 | 6.1e-01 | 8.5e-01 | 8.5e-01 | 2.1e-01 | 7.3e-01 |
| 132 | (KEGG) Longevity regulating pathway | 5.1e-01 | 9.7e-01 | 9.8e-01 | 8.5e-01 | 6.4e-01 | 0.0e+00 |
| 260 | (KEGG) Leishmaniasis | 5.1e-01 | 1.8e-01 | 8.3e-01 | 8.5e-01 | 8.3e-01 | 6.9e-01 |
| 22 | (KEGG) Cysteine and methionine metabolism | 5.1e-01 | 3.8e-01 | 9.4e-01 | 3.0e-01 | 8.5e-01 | 7.1e-01 |
| 46 | (KEGG) Glycerolipid metabolism | 5.1e-01 | 4.4e-01 | 6.0e-01 | 7.9e-01 | 6.9e-01 | 7.7e-01 |
| 52 | (KEGG) Linoleic acid metabolism | 5.1e-01 | 0.0e+00 | 8.7e-01 | 8.5e-01 | 8.4e-01 | 6.3e-01 |
| 223 | (KEGG) Growth hormone synthesis, secretion and action | 5.1e-01 | 3.7e-01 | 6.2e-01 | 9.1e-01 | 2.3e-01 | 6.8e-01 |
| 245 | (KEGG) Prion disease | 5.1e-01 | 5.9e-01 | 6.0e-01 | 9.4e-01 | 3.3e-01 | 6.8e-01 |
| 259 | (KEGG) Yersinia infection | 5.1e-01 | 4.7e-01 | 8.6e-01 | 1.0e+00 | 5.5e-01 | 6.9e-01 |
| 265 | (KEGG) Amoebiasis | 5.1e-01 | 5.7e-01 | 8.8e-01 | 8.5e-01 | 7.8e-01 | 6.9e-01 |
| 277 | (KEGG) Epstein-Barr virus infection | 5.1e-01 | 5.1e-01 | 7.8e-01 | 9.4e-01 | 1.4e-01 | 5.5e-01 |
| 207 | (KEGG) Thyroid hormone signaling pathway | 5.2e-01 | 4.1e-01 | 8.1e-01 | 8.5e-01 | 9.8e-01 | 4.4e-01 |
| 211 | (KEGG) Regulation of lipolysis in adipocytes | 5.3e-01 | 4.4e-01 | 8.8e-01 | 9.4e-01 | 5.5e-01 | 2.4e-01 |
| 171 | (KEGG) Th1 and Th2 cell differentiation | 5.3e-01 | 5.7e-01 | 7.3e-01 | 6.5e-01 | 2.8e-01 | 6.8e-01 |
| 203 | (KEGG) Estrogen signaling pathway | 5.3e-01 | 3.7e-01 | 6.0e-01 | 9.6e-01 | 7.2e-01 | 7.9e-01 |
| 139 | (KEGG) Adrenergic signaling in cardiomyocytes | 5.3e-01 | 8.8e-01 | 6.0e-01 | 9.4e-01 | 5.6e-01 | 8.0e-01 |
| 148 | (KEGG) Osteoclast differentiation | 5.3e-01 | 6.0e-01 | 9.6e-01 | 7.0e-01 | 3.7e-01 | 3.6e-01 |
| 163 | (KEGG) Toll-like receptor signaling pathway | 5.3e-01 | 2.1e-01 | 6.0e-01 | 9.1e-01 | 1.4e-01 | 6.9e-01 |
| 248 | (KEGG) Amphetamine addiction | 5.3e-01 | 9.3e-01 | 6.0e-01 | 8.5e-01 | 9.2e-01 | 6.0e-01 |
| 146 | (KEGG) VEGF signaling pathway | 5.5e-01 | 8.2e-01 | 9.8e-01 | 9.5e-01 | 6.9e-01 | 3.4e-01 |
| 234 | (KEGG) Carbohydrate digestion and absorption | 5.5e-01 | 6.3e-01 | 8.3e-01 | 9.9e-01 | 8.1e-01 | 7.3e-01 |
| 93 | (KEGG) mRNA surveillance pathway | 5.5e-01 | 8.8e-01 | 6.8e-01 | 9.5e-01 | 3.7e-01 | 6.3e-01 |
| 183 | (KEGG) Long-term potentiation | 5.5e-01 | 9.9e-01 | 9.2e-01 | 9.9e-01 | 8.9e-01 | 3.3e-01 |
| 50 | (KEGG) Ether lipid metabolism | 5.5e-01 | 6.0e-02 | 8.6e-01 | 9.4e-01 | 6.1e-01 | 1.6e-01 |
| 317 | (KEGG) Dilated cardiomyopathy | 5.6e-01 | 3.6e-01 | 7.5e-01 | 1.0e+00 | 7.5e-01 | 2.8e-01 |
| 218 | (KEGG) Type II diabetes mellitus | 5.6e-01 | 4.1e-01 | 9.1e-01 | 7.9e-01 | 4.0e-01 | 4.2e-01 |
| 172 | (KEGG) Th17 cell differentiation | 5.7e-01 | 6.7e-01 | 7.3e-01 | 9.2e-01 | 3.1e-01 | 6.9e-01 |
| 307 | (KEGG) PD-L1 expression and PD-1 checkpoint pathway in cancer | 5.8e-01 | 8.5e-01 | 9.1e-01 | 9.8e-01 | 6.6e-01 | 4.1e-01 |
| 69 | (KEGG) Lipoic acid metabolism | 5.8e-01 | 3.9e-01 | 9.6e-01 | 9.1e-01 | 8.5e-01 | 6.9e-01 |
| 82 | (KEGG) Carbon metabolism | 5.8e-01 | 3.8e-01 | 9.4e-01 | 7.8e-01 | 8.2e-01 | 8.0e-02 |
| 310 | (KEGG) Inflammatory bowel disease | 5.8e-01 | 7.3e-01 | 8.8e-01 | 8.7e-01 | 6.2e-01 | 6.8e-01 |
| 91 | (KEGG) Antifolate resistance | 5.9e-01 | 9.2e-01 | 9.1e-01 | 1.0e+00 | 9.2e-01 | 4.9e-01 |
| 228 | (KEGG) Endocrine and other factor-regulated calcium reabsorption | 5.9e-01 | 9.3e-01 | 9.9e-01 | 7.8e-01 | 9.3e-01 | 9.7e-01 |
| 214 | (KEGG) Relaxin signaling pathway | 5.9e-01 | 4.2e-01 | 6.0e-01 | 8.5e-01 | 7.3e-01 | 5.6e-01 |
| 135 | (KEGG) Ferroptosis | 6.1e-01 | 9.1e-01 | 6.2e-01 | 6.1e-01 | 2.7e-01 | 7.3e-01 |
| 2 | (KEGG) Citrate cycle (TCA cycle) | 6.1e-01 | 4.4e-01 | 1.0e+00 | 8.5e-01 | 7.6e-01 | 2.9e-01 |
| 188 | (KEGG) Cholinergic synapse | 6.1e-01 | 5.4e-01 | 6.4e-01 | 9.9e-01 | 6.3e-01 | 5.9e-01 |
| 225 | (KEGG) Type I diabetes mellitus | 6.2e-01 | 9.1e-01 | 8.6e-01 | 9.0e-01 | 6.4e-01 | 5.9e-01 |
| 309 | (KEGG) Autoimmune thyroid disease | 6.2e-01 | 9.3e-01 | 8.8e-01 | 8.5e-01 | 9.8e-01 | 4.8e-01 |
| 316 | (KEGG) Arrhythmogenic right ventricular cardiomyopathy | 6.2e-01 | 2.2e-01 | 6.9e-01 | 8.5e-01 | 5.6e-01 | 9.8e-01 |
| 157 | (KEGG) Signaling pathways regulating pluripotency of stem cells | 6.2e-01 | 5.7e-01 | 6.0e-01 | 9.2e-01 | 3.7e-01 | 6.8e-01 |
| 232 | (KEGG) Gastric acid secretion | 6.3e-01 | 9.1e-01 | 6.0e-01 | 9.6e-01 | 9.4e-01 | 7.2e-01 |
| 283 | (KEGG) Chemical carcinogenesis - DNA adducts | 6.3e-01 | 4.4e-01 | 7.0e-01 | 9.7e-01 | 4.0e-01 | 3.6e-01 |
| 130 | (KEGG) AMPK signaling pathway | 6.3e-01 | 5.3e-01 | 8.5e-01 | 9.4e-01 | 2.6e-01 | 4.0e-02 |
| 29 | (KEGG) Tryptophan metabolism | 6.3e-01 | 4.8e-01 | 8.7e-01 | 9.3e-01 | 9.2e-01 | 9.7e-01 |
| 61 | (KEGG) Butanoate metabolism | 6.3e-01 | 1.7e-01 | 7.3e-01 | 8.5e-01 | 5.1e-01 | 1.0e+00 |
| 167 | (KEGG) C-type lectin receptor signaling pathway | 6.3e-01 | 7.1e-01 | 7.3e-01 | 8.9e-01 | 2.3e-01 | 7.4e-01 |
| 176 | (KEGG) Fc gamma R-mediated phagocytosis | 6.3e-01 | 5.4e-01 | 9.5e-01 | 9.8e-01 | 4.6e-01 | 3.0e-02 |
| 276 | (KEGG) Herpes simplex virus 1 infection | 6.3e-01 | 1.7e-01 | 7.1e-01 | 8.5e-01 | 2.0e-01 | 4.5e-01 |
| 85 | (KEGG) Biosynthesis of amino acids | 6.4e-01 | 2.6e-01 | 9.0e-01 | 3.4e-01 | 9.8e-01 | 1.7e-01 |
| 198 | (KEGG) Insulin signaling pathway | 6.4e-01 | 1.0e+00 | 9.9e-01 | 8.5e-01 | 5.6e-01 | 0.0e+00 |
| 121 | (KEGG) Autophagy - other | 6.5e-01 | 8.9e-01 | 9.0e-01 | 8.5e-01 | 4.9e-01 | 1.9e-01 |
| 6 | (KEGG) Galactose metabolism | 6.5e-01 | 4.4e-01 | 5.6e-01 | 7.8e-01 | 9.9e-01 | 8.0e-01 |
| 230 | (KEGG) Proximal tubule bicarbonate reclamation | 6.6e-01 | 9.9e-01 | 8.2e-01 | 9.1e-01 | 8.4e-01 | 8.0e-01 |
| 244 | (KEGG) Spinocerebellar ataxia | 6.6e-01 | 5.9e-01 | 6.0e-01 | 9.4e-01 | 3.3e-01 | 4.3e-01 |
| 263 | (KEGG) Malaria | 6.6e-01 | 1.7e-01 | 9.8e-01 | 9.6e-01 | 6.8e-01 | 7.9e-01 |
| 25 | (KEGG) Arginine and proline metabolism | 6.6e-01 | 9.6e-01 | 9.7e-01 | 8.1e-01 | 8.7e-01 | 4.9e-01 |
| 102 | (KEGG) Rap1 signaling pathway | 6.6e-01 | 6.0e-02 | 9.2e-01 | 7.9e-01 | 3.4e-01 | 4.2e-01 |
| 282 | (KEGG) Viral carcinogenesis | 6.6e-01 | 9.4e-01 | 9.1e-01 | 9.0e-01 | 6.5e-01 | 1.9e-01 |
| 57 | (KEGG) Glycosphingolipid biosynthesis - ganglio series | 6.7e-01 | 7.7e-01 | 8.3e-01 | 8.5e-01 | 9.4e-01 | 9.7e-01 |
| 108 | (KEGG) Chemokine signaling pathway | 6.7e-01 | 1.5e-01 | 6.9e-01 | 9.1e-01 | 2.3e-01 | 1.0e-02 |
| 75 | (KEGG) Sulfur metabolism | 6.7e-01 | 3.5e-01 | 8.4e-01 | 3.4e-01 | 3.2e-01 | 1.1e-01 |
| 231 | (KEGG) Salivary secretion | 6.7e-01 | 7.3e-01 | 9.2e-01 | 9.5e-01 | 2.7e-01 | 6.2e-01 |
| 11 | (KEGG) Steroid biosynthesis | 6.8e-01 | 8.1e-01 | 6.0e-01 | 9.4e-01 | 9.9e-01 | 9.5e-01 |
| 199 | (KEGG) Insulin secretion | 6.9e-01 | 5.0e-01 | 6.0e-01 | 9.6e-01 | 8.5e-01 | 8.8e-01 |
| 114 | (KEGG) Phospholipase D signaling pathway | 6.9e-01 | 4.1e-01 | 9.5e-01 | 9.6e-01 | 3.4e-01 | 1.1e-01 |
| 71 | (KEGG) Retinol metabolism | 7.0e-01 | 9.4e-01 | 9.1e-01 | 9.6e-01 | 6.9e-01 | 4.7e-01 |
| 299 | (KEGG) Acute myeloid leukemia | 7.0e-01 | 2.6e-01 | 9.0e-01 | 7.9e-01 | 4.5e-01 | 4.0e-01 |
| 144 | (KEGG) TGF-beta signaling pathway | 7.0e-01 | 3.7e-01 | 6.0e-01 | 8.0e-01 | 6.4e-01 | 2.8e-01 |
| 221 | (KEGG) AGE-RAGE signaling pathway in diabetic complications | 7.0e-01 | 5.0e-02 | 8.8e-01 | 9.4e-01 | 3.3e-01 | 5.0e-01 |
| 17 | (KEGG) Purine metabolism | 7.0e-01 | 5.7e-01 | 2.4e-01 | 8.8e-01 | 3.2e-01 | 3.4e-01 |
| 120 | (KEGG) SNARE interactions in vesicular transport | 7.0e-01 | 6.1e-01 | 8.7e-01 | 9.4e-01 | 6.5e-01 | 3.3e-01 |
| 308 | (KEGG) Asthma | 7.0e-01 | 8.1e-01 | 1.0e+00 | 9.4e-01 | 8.7e-01 | 3.5e-01 |
| 96 | (KEGG) PPAR signaling pathway | 7.0e-01 | 4.0e-02 | 8.5e-01 | 9.1e-01 | 6.8e-01 | 1.6e-01 |
| 126 | (KEGG) Phagosome | 7.0e-01 | 8.1e-01 | 6.5e-01 | 9.5e-01 | 9.2e-01 | 8.4e-01 |
| 159 | (KEGG) Platelet activation | 7.0e-01 | 3.0e-01 | 9.5e-01 | 8.5e-01 | 8.1e-01 | 8.0e-02 |
| 239 | (KEGG) Cholesterol metabolism | 7.0e-01 | 5.1e-01 | 8.7e-01 | 8.4e-01 | 7.3e-01 | 4.5e-01 |
| 63 | (KEGG) Thiamine metabolism | 7.0e-01 | 6.3e-01 | 8.6e-01 | 9.0e-01 | 9.1e-01 | 6.4e-01 |
| 70 | (KEGG) Folate biosynthesis | 7.0e-01 | 6.8e-01 | 7.7e-01 | 8.9e-01 | 5.7e-01 | 9.9e-01 |
| 254 | (KEGG) Pathogenic Escherichia coli infection | 7.1e-01 | 4.1e-01 | 9.3e-01 | 1.0e+00 | 9.4e-01 | 4.6e-01 |
| 128 | (KEGG) mTOR signaling pathway | 7.1e-01 | 6.1e-01 | 7.3e-01 | 8.5e-01 | 6.6e-01 | 2.4e-01 |
| 226 | (KEGG) Maturity onset diabetes of the young | 7.1e-01 | 9.5e-01 | 9.6e-01 | 9.0e-01 | 5.9e-01 | 6.5e-01 |
| 115 | (KEGG) Neuroactive ligand-receptor interaction | 7.1e-01 | 9.9e-01 | 6.2e-01 | 9.5e-01 | 6.1e-01 | 2.0e-02 |
| 256 | (KEGG) Salmonella infection | 7.1e-01 | 2.9e-01 | 6.0e-01 | 1.0e+00 | 6.7e-01 | 6.9e-01 |
| 18 | (KEGG) Caffeine metabolism | 7.2e-01 | 7.6e-01 | 7.3e-01 | 8.2e-01 | 5.3e-01 | 9.4e-01 |
| 80 | (KEGG) Biosynthesis of unsaturated fatty acids | 7.2e-01 | 6.3e-01 | 6.9e-01 | 9.4e-01 | 6.5e-01 | 2.8e-01 |
| 77 | (KEGG) Metabolism of xenobiotics by cytochrome P450 | 7.3e-01 | 4.3e-01 | 7.8e-01 | 8.5e-01 | 4.9e-01 | 3.7e-01 |
| 1 | (KEGG) Glycolysis / Gluconeogenesis | 7.3e-01 | 9.1e-01 | 9.2e-01 | 9.9e-01 | 9.3e-01 | 6.0e-02 |
| 7 | (KEGG) Ascorbate and aldarate metabolism | 7.4e-01 | 9.2e-01 | 8.0e-01 | 8.4e-01 | 8.9e-01 | 7.7e-01 |
| 181 | (KEGG) Circadian entrainment | 7.4e-01 | 8.1e-01 | 8.7e-01 | 9.5e-01 | 2.7e-01 | 9.1e-01 |
| 311 | (KEGG) Systemic lupus erythematosus | 7.5e-01 | 6.4e-01 | 9.0e-01 | 8.4e-01 | 9.8e-01 | 3.3e-01 |
| 202 | (KEGG) Progesterone-mediated oocyte maturation | 7.5e-01 | 8.1e-01 | 6.7e-01 | 1.0e+00 | 9.4e-01 | 4.1e-01 |
| 56 | (KEGG) Glycosphingolipid biosynthesis - globo and isoglobo series | 7.5e-01 | 6.7e-01 | 8.5e-01 | 9.4e-01 | 5.0e-01 | 5.4e-01 |
| 187 | (KEGG) Glutamatergic synapse | 7.5e-01 | 8.7e-01 | 9.0e-01 | 9.3e-01 | 7.8e-01 | 3.7e-01 |
| 37 | (KEGG) Starch and sucrose metabolism | 7.5e-01 | 5.2e-01 | 9.6e-01 | 7.9e-01 | 8.4e-01 | 4.8e-01 |
| 251 | (KEGG) Bacterial invasion of epithelial cells | 7.5e-01 | 1.0e+00 | 8.3e-01 | 9.4e-01 | 6.4e-01 | 8.4e-01 |
| 42 | (KEGG) Amino sugar and nucleotide sugar metabolism | 7.6e-01 | 9.2e-01 | 8.3e-01 | 3.0e-01 | 9.8e-01 | 8.2e-01 |
| 107 | (KEGG) Viral protein interaction with cytokine and cytokine receptor | 7.6e-01 | 1.7e-01 | 7.6e-01 | 8.1e-01 | 2.3e-01 | 0.0e+00 |
| 142 | (KEGG) Notch signaling pathway | 7.6e-01 | 4.4e-01 | 9.6e-01 | 8.1e-01 | 7.8e-01 | 3.1e-01 |
| 200 | (KEGG) GnRH signaling pathway | 7.6e-01 | 4.7e-01 | 9.9e-01 | 9.4e-01 | 6.5e-01 | 4.4e-01 |
| 47 | (KEGG) Inositol phosphate metabolism | 7.6e-01 | 6.1e-01 | 8.3e-01 | 9.7e-01 | 3.6e-01 | 4.0e-01 |
| 270 | (KEGG) Measles | 7.7e-01 | 0.0e+00 | 7.8e-01 | 8.9e-01 | 1.4e-01 | 2.2e-01 |
| 78 | (KEGG) Drug metabolism - cytochrome P450 | 7.8e-01 | 3.8e-01 | 6.1e-01 | 9.4e-01 | 3.0e-01 | 5.8e-01 |
| 174 | (KEGG) B cell receptor signaling pathway | 7.8e-01 | 5.0e-02 | 6.0e-01 | 8.6e-01 | 2.6e-01 | 8.9e-01 |
| 190 | (KEGG) GABAergic synapse | 7.8e-01 | 9.9e-01 | 9.2e-01 | 9.1e-01 | 7.8e-01 | 7.9e-01 |
| 119 | (KEGG) Sulfur relay system | 7.8e-01 | 2.9e-01 | 9.2e-01 | 1.0e+00 | 3.5e-01 | 4.6e-01 |
| 156 | (KEGG) Gap junction | 7.8e-01 | 5.7e-01 | 8.3e-01 | 1.0e+00 | 9.8e-01 | 6.0e-01 |
| 165 | (KEGG) RIG-I-like receptor signaling pathway | 7.8e-01 | 7.1e-01 | 6.2e-01 | 9.4e-01 | 2.7e-01 | 5.6e-01 |
| 204 | (KEGG) Melanogenesis | 7.9e-01 | 1.5e-01 | 6.0e-01 | 9.2e-01 | 2.7e-01 | 6.6e-01 |
| 173 | (KEGG) T cell receptor signaling pathway | 7.9e-01 | 7.0e-01 | 8.7e-01 | 9.9e-01 | 6.1e-01 | 6.3e-01 |
| 289 | (KEGG) Renal cell carcinoma | 7.9e-01 | 5.4e-01 | 8.8e-01 | 1.0e+00 | 6.4e-01 | 8.4e-01 |
| 97 | (KEGG) Homologous recombination | 8.0e-01 | 9.4e-01 | 7.6e-01 | 9.4e-01 | 9.8e-01 | 9.8e-01 |
| 88 | (KEGG) Biosynthesis of nucleotide sugars | 8.0e-01 | 9.0e-01 | 7.2e-01 | 2.7e-01 | 9.2e-01 | 7.3e-01 |
| 76 | (KEGG) Aminoacyl-tRNA biosynthesis | 8.0e-01 | 8.1e-01 | 6.0e-01 | 9.4e-01 | 9.2e-01 | 1.0e+00 |
| 175 | (KEGG) Fc epsilon RI signaling pathway | 8.1e-01 | 4.3e-01 | 1.0e+00 | 9.6e-01 | 4.2e-01 | 7.3e-01 |
| 219 | (KEGG) Insulin resistance | 8.2e-01 | 8.9e-01 | 7.3e-01 | 8.0e-01 | 5.4e-01 | 4.0e-02 |
| 87 | (KEGG) Biosynthesis of cofactors | 8.2e-01 | 6.1e-01 | 6.7e-01 | 8.3e-01 | 9.9e-01 | 6.9e-01 |
| 21 | (KEGG) Glycine, serine and threonine metabolism | 8.2e-01 | 3.3e-01 | 9.9e-01 | 7.8e-01 | 9.1e-01 | 1.7e-01 |
| 236 | (KEGG) Bile secretion | 8.2e-01 | 4.7e-01 | 9.8e-01 | 1.0e+00 | 8.3e-01 | 9.8e-01 |
| 178 | (KEGG) Leukocyte transendothelial migration | 8.2e-01 | 1.2e-01 | 8.5e-01 | 9.6e-01 | 6.4e-01 | 1.1e-01 |
| 23 | (KEGG) Valine, leucine and isoleucine degradation | 8.3e-01 | 1.7e-01 | 9.6e-01 | 8.5e-01 | 3.2e-01 | 2.5e-01 |
| 235 | (KEGG) Fat digestion and absorption | 8.3e-01 | 9.6e-01 | 6.0e-01 | 9.4e-01 | 9.7e-01 | 9.1e-01 |
| 60 | (KEGG) Propanoate metabolism | 8.3e-01 | 5.6e-01 | 9.7e-01 | 7.8e-01 | 6.1e-01 | 6.8e-01 |
| 66 | (KEGG) Nicotinate and nicotinamide metabolism | 8.3e-01 | 9.2e-01 | 9.3e-01 | 9.5e-01 | 6.5e-01 | 7.8e-01 |
| 205 | (KEGG) Prolactin signaling pathway | 8.3e-01 | 6.9e-01 | 7.0e-01 | 8.5e-01 | 2.1e-01 | 5.4e-01 |
| 196 | (KEGG) Inflammatory mediator regulation of TRP channels | 8.3e-01 | 6.2e-01 | 9.3e-01 | 1.0e+00 | 4.6e-01 | 5.4e-01 |
| 32 | (KEGG) Taurine and hypotaurine metabolism | 8.4e-01 | 4.6e-01 | 8.5e-01 | 8.4e-01 | 3.4e-01 | 3.8e-01 |
| 95 | (KEGG) Viral life cycle - HIV-1 | 8.4e-01 | 9.1e-01 | 8.3e-01 | 9.4e-01 | 6.8e-01 | 8.5e-01 |
| 117 | (KEGG) Oocyte meiosis | 8.4e-01 | 8.4e-01 | 7.4e-01 | 9.2e-01 | 8.7e-01 | 1.9e-01 |
| 184 | (KEGG) Synaptic vesicle cycle | 8.5e-01 | 9.0e-01 | 8.7e-01 | 8.5e-01 | 3.2e-01 | 9.9e-01 |
| 73 | (KEGG) Terpenoid backbone biosynthesis | 8.5e-01 | 4.4e-01 | 9.0e-01 | 8.5e-01 | 3.5e-01 | 1.0e+00 |
| 136 | (KEGG) Necroptosis | 8.5e-01 | 8.5e-01 | 6.0e-01 | 8.5e-01 | 3.5e-01 | 7.9e-01 |
| 201 | (KEGG) Ovarian steroidogenesis | 8.5e-01 | 8.5e-01 | 9.7e-01 | 9.5e-01 | 7.3e-01 | 7.3e-01 |
| 3 | (KEGG) Pentose phosphate pathway | 8.5e-01 | 3.7e-01 | 8.5e-01 | 9.8e-01 | 8.6e-01 | 5.1e-01 |
| 252 | (KEGG) Vibrio cholerae infection | 8.5e-01 | 8.1e-01 | 9.7e-01 | 9.9e-01 | 6.9e-01 | 7.2e-01 |
| 215 | (KEGG) Cortisol synthesis and secretion | 8.5e-01 | 4.4e-01 | 6.0e-01 | 9.1e-01 | 7.8e-01 | 7.3e-01 |
| 67 | (KEGG) Pantothenate and CoA biosynthesis | 8.5e-01 | 6.9e-01 | 9.7e-01 | 3.4e-01 | 9.7e-01 | 5.9e-01 |
| 318 | (KEGG) Diabetic cardiomyopathy | 8.5e-01 | 5.0e-01 | 9.6e-01 | 1.0e+00 | 8.7e-01 | 7.0e-01 |
| 233 | (KEGG) Pancreatic secretion | 8.6e-01 | 5.8e-01 | 9.6e-01 | 9.4e-01 | 8.7e-01 | 9.1e-01 |
| 35 | (KEGG) D-Amino acid metabolism | 8.6e-01 | 5.6e-01 | 7.1e-01 | 9.4e-01 | 7.1e-01 | 8.9e-01 |
| 58 | (KEGG) Pyruvate metabolism | 8.7e-01 | 4.8e-01 | 7.8e-01 | 9.6e-01 | 9.3e-01 | 2.2e-01 |
| 266 | (KEGG) Staphylococcus aureus infection | 8.7e-01 | 8.1e-01 | 1.0e+00 | 8.8e-01 | 7.1e-01 | 4.0e-02 |
| 279 | (KEGG) Coronavirus disease - COVID-19 | 8.7e-01 | 1.1e-01 | 8.7e-01 | 8.4e-01 | 4.3e-01 | 8.1e-01 |
| 19 | (KEGG) Pyrimidine metabolism | 8.7e-01 | 9.0e-01 | 9.0e-01 | 9.5e-01 | 8.9e-01 | 8.2e-01 |
| 162 | (KEGG) Renin-angiotensin system | 8.8e-01 | 6.1e-01 | 9.6e-01 | 9.2e-01 | 9.6e-01 | 2.4e-01 |
| 127 | (KEGG) Peroxisome | 8.8e-01 | 9.9e-01 | 9.4e-01 | 9.6e-01 | 5.1e-01 | 6.5e-01 |
| 4 | (KEGG) Pentose and glucuronate interconversions | 8.8e-01 | 9.8e-01 | 6.0e-01 | 7.8e-01 | 8.5e-01 | 2.7e-01 |
| 44 | (KEGG) Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 8.8e-01 | 9.5e-01 | 8.0e-01 | 9.4e-01 | 5.6e-01 | 5.0e-01 |
| 48 | (KEGG) Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 8.8e-01 | 9.6e-01 | 6.0e-01 | 1.0e+00 | 6.9e-01 | 8.3e-01 |
| 155 | (KEGG) Tight junction | 8.9e-01 | 1.8e-01 | 8.7e-01 | 8.5e-01 | 8.9e-01 | 3.4e-01 |
| 161 | (KEGG) Neutrophil extracellular trap formation | 8.9e-01 | 1.9e-01 | 9.7e-01 | 9.8e-01 | 5.6e-01 | 5.3e-01 |
| 72 | (KEGG) Porphyrin metabolism | 9.0e-01 | 5.3e-01 | 9.4e-01 | 9.6e-01 | 9.4e-01 | 3.4e-01 |
| 206 | (KEGG) Thyroid hormone synthesis | 9.0e-01 | 3.6e-01 | 6.0e-01 | 9.5e-01 | 8.4e-01 | 5.5e-01 |
| 55 | (KEGG) Glycosphingolipid biosynthesis - lacto and neolacto series | 9.1e-01 | 8.0e-01 | 9.9e-01 | 6.6e-01 | 6.1e-01 | 5.0e-02 |
| 62 | (KEGG) One carbon pool by folate | 9.1e-01 | 8.3e-01 | 9.6e-01 | 8.5e-01 | 7.0e-01 | 9.2e-01 |
| 217 | (KEGG) GnRH secretion | 9.1e-01 | 6.9e-01 | 9.9e-01 | 9.0e-01 | 4.6e-01 | 5.6e-01 |
| 249 | (KEGG) Morphine addiction | 9.1e-01 | 6.4e-01 | 9.4e-01 | 9.1e-01 | 8.4e-01 | 3.3e-01 |
| 12 | (KEGG) Primary bile acid biosynthesis | 9.1e-01 | 9.7e-01 | 7.3e-01 | 3.0e-01 | 6.9e-01 | 6.8e-01 |
| 133 | (KEGG) Longevity regulating pathway - multiple species | 9.1e-01 | 9.1e-01 | 7.6e-01 | 9.6e-01 | 7.1e-01 | 3.0e-02 |
| 112 | (KEGG) Phosphatidylinositol signaling system | 9.2e-01 | 7.2e-01 | 8.6e-01 | 9.7e-01 | 4.3e-01 | 7.9e-01 |
| 125 | (KEGG) Endocytosis | 9.2e-01 | 6.9e-01 | 8.5e-01 | 9.5e-01 | 5.4e-01 | 8.6e-01 |
| 14 | (KEGG) Steroid hormone biosynthesis | 9.3e-01 | 8.7e-01 | 9.4e-01 | 9.4e-01 | 9.0e-01 | 8.4e-01 |
| 9 | (KEGG) Fatty acid elongation | 9.3e-01 | 9.6e-01 | 9.8e-01 | 8.5e-01 | 7.7e-01 | 2.3e-01 |
| 194 | (KEGG) Taste transduction | 9.3e-01 | 3.8e-01 | 6.0e-01 | 9.9e-01 | 8.9e-01 | 8.1e-01 |
| 319 | (KEGG) Viral myocarditis | 9.3e-01 | 9.7e-01 | 7.3e-01 | 9.4e-01 | 9.9e-01 | 6.0e-02 |
| 83 | (KEGG) 2-Oxocarboxylic acid metabolism | 9.4e-01 | 5.6e-01 | 9.2e-01 | 7.8e-01 | 9.3e-01 | 3.4e-01 |
| 24 | (KEGG) Lysine degradation | 9.4e-01 | 7.8e-01 | 9.6e-01 | 9.1e-01 | 8.5e-01 | 9.7e-01 |
| 30 | (KEGG) Phenylalanine, tyrosine and tryptophan biosynthesis | 9.4e-01 | 7.0e-01 | 8.6e-01 | 3.0e-01 | 7.5e-01 | 4.3e-01 |
| 68 | (KEGG) Biotin metabolism | 9.4e-01 | 2.1e-01 | 8.1e-01 | 9.9e-01 | 7.7e-01 | 9.7e-01 |
| 197 | (KEGG) Regulation of actin cytoskeleton | 9.4e-01 | 1.6e-01 | 7.7e-01 | 9.9e-01 | 6.3e-01 | 0.0e+00 |
| 86 | (KEGG) Nucleotide metabolism | 9.4e-01 | 6.5e-01 | 6.5e-01 | 9.5e-01 | 7.2e-01 | 8.8e-01 |
| 150 | (KEGG) Hippo signaling pathway - multiple species | 9.4e-01 | 1.6e-01 | 6.0e-01 | 7.8e-01 | 5.3e-01 | 6.1e-01 |
| 213 | (KEGG) Aldosterone synthesis and secretion | 9.5e-01 | 8.9e-01 | 6.0e-01 | 8.5e-01 | 9.0e-01 | 7.1e-01 |
| 186 | (KEGG) Retrograde endocannabinoid signaling | 9.6e-01 | 3.0e-01 | 8.9e-01 | 9.6e-01 | 9.1e-01 | 7.2e-01 |
| 306 | (KEGG) Choline metabolism in cancer | 9.6e-01 | 6.1e-01 | 9.0e-01 | 9.7e-01 | 2.6e-01 | 4.6e-01 |
| 13 | (KEGG) Ubiquinone and other terpenoid-quinone biosynthesis | 9.7e-01 | 6.1e-01 | 9.6e-01 | 7.8e-01 | 9.8e-01 | 8.4e-01 |
| 41 | (KEGG) Mannose type O-glycan biosynthesis | 9.7e-01 | 9.5e-01 | 6.0e-01 | 9.9e-01 | 5.6e-01 | 5.5e-01 |
| 65 | (KEGG) Vitamin B6 metabolism | 9.8e-01 | 7.7e-01 | 8.3e-01 | 9.4e-01 | 4.3e-01 | 9.8e-01 |
| 31 | (KEGG) beta-Alanine metabolism | 9.8e-01 | 5.8e-01 | 9.1e-01 | 9.1e-01 | 7.4e-01 | 8.9e-01 |
| 193 | (KEGG) Olfactory transduction | 9.8e-01 | 7.8e-01 | 9.9e-01 | 1.0e+00 | 7.0e-01 | 3.6e-01 |
| 33 | (KEGG) Phosphonate and phosphinate metabolism | 9.8e-01 | 8.1e-01 | 9.4e-01 | 7.8e-01 | 2.7e-01 | 8.0e-01 |
| 40 | (KEGG) Various types of N-glycan biosynthesis | 9.9e-01 | 7.6e-01 | 8.7e-01 | 9.7e-01 | 7.8e-01 | 2.8e-01 |
| 59 | (KEGG) Glyoxylate and dicarboxylate metabolism | 9.9e-01 | 5.4e-01 | 1.0e+00 | 9.6e-01 | 8.0e-01 | 2.4e-01 |
| 195 | (KEGG) Phototransduction | 1.0e+00 | 9.8e-01 | 7.3e-01 | 9.7e-01 | 8.1e-01 | 2.9e-01 |
| 38 | (KEGG) N-Glycan biosynthesis | 1.0e+00 | 9.1e-01 | 8.9e-01 | 9.4e-01 | 8.5e-01 | 7.5e-01 |
| 182 | (KEGG) Thermogenesis | 1.0e+00 | 9.2e-01 | 7.3e-01 | 9.3e-01 | 3.8e-01 | 8.0e-02 |
| 322 | (KEGG) Valine, leucine and isoleucine biosynthesis | NA | NA | NA | NA | NA | NA |
| 323 | (KEGG) Neomycin, kanamycin and gentamicin biosynthesis | NA | NA | NA | NA | NA | NA |
| 324 | (KEGG) Protein digestion and absorption | NA | NA | NA | NA | NA | NA |
| 325 | (KEGG) Nicotine addiction | NA | NA | NA | NA | NA | NA |
KEGG %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table 6. Integrated transcriptomic and metabolomic KEGG pathway analysis - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))Combined_TransMet %>% dplyr::filter(grepl("REACTOME",Pathway)) -> Reactome
Reactome[,c(1,21,11,6,16,26,31)] -> ReactomeTable
ReactomeTable[order(ReactomeTable$Lung_Combined_pval),] -> ReactomeTable
ReactomeTable %>%
mutate(
Lung_Combined_pval=format(round(Lung_Combined_pval,2),nsmall=2,scientific=TRUE),
HT_Combined_pval=format(round(HT_Combined_pval,2),nsmall=2,scientific=TRUE),
Adrenal_Combined_pval=format(round(Adrenal_Combined_pval,2),nsmall=2,scientific=TRUE),
Liver_Combined_pval=format(round(Liver_Combined_pval,2),nsmall=2,scientific=TRUE),
Adipose_Combined_pval=format(round(Adipose_Combined_pval,2),nsmall=2,scientific=TRUE),
Muscle_Combined_pval=format(round(Muscle_Combined_pval,2),nsmall=2,scientific=TRUE)) %>% kable(caption = "Supplementary Table 7. Integrated transcriptomic and metabolomic Reactome pathway analysis", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(5,bold=ifelse(is.na(ReactomeTable$Adrenal_Combined_pval),F,ifelse(ReactomeTable$Adrenal_Combined_pval<.1,T,F)),color= ifelse(is.na(ReactomeTable$Adrenal_Combined_pval),"gray",ifelse(ReactomeTable$Adrenal_Combined_pval <.1,"#fdc4ad","gray"))) %>%
column_spec(4,bold=ifelse(is.na(ReactomeTable$HT_Combined_pval),F,ifelse(ReactomeTable$HT_Combined_pval<.1,T,F)),color= ifelse(is.na(ReactomeTable$HT_Combined_pval),"gray",ifelse(ReactomeTable$HT_Combined_pval <.1,"#c2cce3","gray"))) %>%
column_spec(6,bold=ifelse(is.na(ReactomeTable$Liver_Combined_pval),F,ifelse(ReactomeTable$Liver_Combined_pval<.1,T,F)),color= ifelse(is.na(ReactomeTable$Liver_Combined_pval),"gray",ifelse(ReactomeTable$Liver_Combined_pval <.1,"#f0b4d9","gray"))) %>%
column_spec(3,bold=ifelse(is.na(ReactomeTable$Lung_Combined_pval),F,ifelse(ReactomeTable$Lung_Combined_pval<.1,T,F)),color= ifelse(is.na(ReactomeTable$Lung_Combined_pval),"gray",ifelse(ReactomeTable$Lung_Combined_pval <.1,"#c6e692","gray"))) %>%
column_spec(7,bold=ifelse(is.na(ReactomeTable$Adipose_Combined_pval),F,ifelse(ReactomeTable$Adipose_Combined_pval<.1,T,F)),color= ifelse(is.na(ReactomeTable$Adipose_Combined_pval),"gray",ifelse(ReactomeTable$Adipose_Combined_pval <.1,"#9dd8c5","gray"))) %>%
column_spec(8,bold=ifelse(is.na(ReactomeTable$Muscle_Combined_pval),F,ifelse(ReactomeTable$Muscle_Combined_pval<.1,T,F)),color= ifelse(is.na(ReactomeTable$Muscle_Combined_pval),"gray",ifelse(ReactomeTable$Muscle_Combined_pval <.1,"#e0b880","gray"))) %>%
scroll_box(width = "1200px", height = "500px")| Pathway | Lung_Combined_pval | HT_Combined_pval | Adrenal_Combined_pval | Liver_Combined_pval | Adipose_Combined_pval | Muscle_Combined_pval | |
|---|---|---|---|---|---|---|---|
| 1145 | (REACTOME) Metabolism of lipids | 3.0e-02 | 4.0e-02 | 4.1e-01 | 2.0e-01 | 5.0e-02 | 3.4e-01 |
| 1023 | (REACTOME) Signaling by Interleukins | 3.0e-02 | 3.1e-01 | 6.3e-01 | 9.6e-01 | 4.5e-01 | 5.0e-01 |
| 2124 | (REACTOME) KEAP1-NFE2L2 pathway | 3.0e-02 | 1.1e-01 | 6.0e-01 | 9.4e-01 | 1.7e-01 | 2.0e-02 |
| 1044 | (REACTOME) Mitotic G1 phase and G1/S transition | 4.0e-02 | 1.6e-01 | 9.1e-01 | 7.8e-01 | 1.4e-01 | 5.9e-01 |
| 149 | (REACTOME) Metabolism | 4.0e-02 | 0.0e+00 | 6.8e-01 | 2.0e-02 | 4.0e-02 | 1.0e-02 |
| 255 | (REACTOME) Disease | 4.0e-02 | 4.7e-01 | 8.5e-01 | 9.1e-01 | 8.0e-01 | 5.3e-01 |
| 1360 | (REACTOME) Interleukin-4 and Interleukin-13 signaling | 4.0e-02 | 6.4e-01 | 9.2e-01 | 8.5e-01 | 3.4e-01 | 3.9e-01 |
| 1443 | (REACTOME) G1/S Transition | 4.0e-02 | 1.6e-01 | 9.0e-01 | 7.8e-01 | 1.4e-01 | 3.7e-01 |
| 1447 | (REACTOME) S Phase | 4.0e-02 | 1.4e-01 | 9.4e-01 | 9.0e-01 | 1.4e-01 | 2.2e-01 |
| 1466 | (REACTOME) Cyclin A:Cdk2-associated events at S phase entry | 4.0e-02 | 2.8e-01 | 6.0e-01 | 8.5e-01 | 1.7e-01 | 3.3e-01 |
| 684 | (REACTOME) Senescence-Associated Secretory Phenotype (SASP) | 4.0e-02 | 1.2e-01 | 9.5e-01 | 8.2e-01 | 2.7e-01 | 1.1e-01 |
| 802 | (REACTOME) Transcriptional Regulation by TP53 | 4.0e-02 | 5.0e-02 | 9.0e-01 | 8.5e-01 | 6.4e-01 | 0.0e+00 |
| 850 | (REACTOME) Transport of small molecules | 4.0e-02 | 7.3e-01 | 9.6e-01 | 3.0e-01 | 3.4e-01 | 6.0e-01 |
| 1441 | (REACTOME) Cyclin E associated events during G1/S transition | 4.0e-02 | 2.7e-01 | 6.0e-01 | 8.5e-01 | 1.4e-01 | 3.4e-01 |
| 1500 | (REACTOME) Eukaryotic Translation Initiation | 4.0e-02 | 0.0e+00 | 3.3e-01 | 8.5e-01 | 8.0e-02 | 1.0e-02 |
| 1508 | (REACTOME) Cap-dependent Translation Initiation | 4.0e-02 | 0.0e+00 | 3.3e-01 | 8.5e-01 | 8.0e-02 | 1.0e-02 |
| 1621 | (REACTOME) The role of GTSE1 in G2/M progression after G2 checkpoint | 4.0e-02 | 1.0e-02 | 6.0e-01 | 8.1e-01 | 1.5e-01 | 2.0e-02 |
| 1649 | (REACTOME) TFAP2 (AP-2) family regulates transcription of cell cycle factors | 4.0e-02 | 2.0e-02 | 5.9e-01 | 3.4e-01 | 1.4e-01 | 5.0e-02 |
| 2136 | (REACTOME) Nuclear events mediated by NFE2L2 | 4.0e-02 | 1.3e-01 | 6.0e-01 | 8.5e-01 | 1.7e-01 | 1.1e-01 |
| 1366 | (REACTOME) TP53 Regulates Transcription of Cell Cycle Genes | 5.0e-02 | 1.3e-01 | 7.5e-01 | 3.0e-01 | 6.1e-01 | 9.5e-01 |
| 2027 | (REACTOME) FLT3 signaling in disease | 5.0e-02 | 1.9e-01 | 8.3e-01 | 7.8e-01 | 4.5e-01 | 2.0e-02 |
| 907 | (REACTOME) Circadian Clock | 5.0e-02 | 8.1e-01 | 9.1e-01 | 9.1e-01 | 3.4e-01 | 2.9e-01 |
| 1539 | (REACTOME) Gene expression (Transcription) | 5.0e-02 | 3.8e-01 | 8.5e-01 | 8.1e-01 | 9.0e-02 | 0.0e+00 |
| 616 | (REACTOME) Generic Transcription Pathway | 5.0e-02 | 3.1e-01 | 9.5e-01 | 8.5e-01 | 2.5e-01 | 1.0e-02 |
| 1151 | (REACTOME) Phase 1 - inactivation of fast Na+ channels | 5.0e-02 | 7.0e-02 | 9.7e-01 | 9.4e-01 | 7.9e-01 | 1.8e-01 |
| 1463 | (REACTOME) G1/S DNA Damage Checkpoints | 5.0e-02 | 6.0e-02 | 6.2e-01 | 7.8e-01 | 1.4e-01 | 5.0e-02 |
| 1522 | (REACTOME) RNA Polymerase II Transcription | 5.0e-02 | 3.3e-01 | 9.2e-01 | 8.3e-01 | 1.4e-01 | 1.0e-02 |
| 197 | (REACTOME) L13a-mediated translational silencing of Ceruloplasmin expression | 5.0e-02 | 0.0e+00 | 3.3e-01 | 9.4e-01 | 1.4e-01 | 2.0e-02 |
| 1506 | (REACTOME) GTP hydrolysis and joining of the 60S ribosomal subunit | 5.0e-02 | 0.0e+00 | 3.3e-01 | 9.4e-01 | 1.4e-01 | 1.0e-02 |
| 1638 | (REACTOME) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 5.0e-02 | 1.1e-01 | 6.0e-01 | 3.9e-01 | 4.0e-01 | 7.9e-01 |
| 11 | (REACTOME) Translesion Synthesis by POLH | 6.0e-02 | 2.0e-01 | 9.4e-01 | 9.2e-01 | 2.8e-01 | 2.0e-02 |
| 1444 | (REACTOME) Cyclin D associated events in G1 | 6.0e-02 | 4.1e-01 | 9.2e-01 | 8.5e-01 | 3.7e-01 | 6.3e-01 |
| 1445 | (REACTOME) G1 Phase | 6.0e-02 | 4.1e-01 | 9.2e-01 | 8.5e-01 | 3.7e-01 | 6.3e-01 |
| 1458 | (REACTOME) p53-Dependent G1 DNA Damage Response | 6.0e-02 | 7.0e-02 | 8.3e-01 | 7.8e-01 | 1.7e-01 | 5.0e-02 |
| 1459 | (REACTOME) p53-Dependent G1/S DNA damage checkpoint | 6.0e-02 | 7.0e-02 | 8.3e-01 | 7.8e-01 | 1.7e-01 | 5.0e-02 |
| 2093 | (REACTOME) Cellular response to chemical stress | 6.0e-02 | 1.8e-01 | 7.5e-01 | 9.6e-01 | 1.0e-01 | 1.2e-01 |
| 1018 | (REACTOME) CHL1 interactions | 8.0e-02 | 6.4e-01 | 6.2e-01 | 9.6e-01 | 7.8e-01 | 6.9e-01 |
| 1775 | (REACTOME) Regulation of expression of SLITs and ROBOs | 8.0e-02 | 0.0e+00 | 5.9e-01 | 9.9e-01 | 8.0e-02 | 1.0e-02 |
| 1923 | (REACTOME) Response of EIF2AK4 (GCN2) to amino acid deficiency | 8.0e-02 | 0.0e+00 | 5.2e-01 | 9.6e-01 | 1.6e-01 | 4.0e-02 |
| 934 | (REACTOME) Role of second messengers in netrin-1 signaling | 8.0e-02 | 7.2e-01 | 9.6e-01 | 9.4e-01 | 3.3e-01 | 3.7e-01 |
| 22 | (REACTOME) Activation of NOXA and translocation to mitochondria | 8.0e-02 | 9.7e-01 | 9.2e-01 | 8.5e-01 | 5.2e-01 | 3.5e-01 |
| 318 | (REACTOME) Immune System | 8.0e-02 | 4.3e-01 | 8.1e-01 | 9.4e-01 | 6.8e-01 | 4.8e-01 |
| 413 | (REACTOME) Serotonin Neurotransmitter Release Cycle | 8.0e-02 | 9.4e-01 | 9.4e-01 | 8.5e-01 | 4.3e-01 | 5.5e-01 |
| 418 | (REACTOME) EGFR downregulation | 8.0e-02 | 5.7e-01 | 9.2e-01 | 9.4e-01 | 6.1e-01 | 7.1e-01 |
| 1285 | (REACTOME) Negative regulation of MAPK pathway | 8.0e-02 | 4.3e-01 | 7.3e-01 | 9.0e-01 | 5.1e-01 | 7.9e-01 |
| 1654 | (REACTOME) MET activates PTK2 signaling | 8.0e-02 | 3.3e-01 | 7.3e-01 | 9.4e-01 | 8.5e-01 | 5.4e-01 |
| 2071 | (REACTOME) Signaling by FLT3 ITD and TKD mutants | 8.0e-02 | 1.6e-01 | 6.3e-01 | 4.2e-01 | 3.7e-01 | 8.0e-02 |
| 1258 | (REACTOME) Translesion synthesis by POLI | 8.0e-02 | 4.9e-01 | 7.3e-01 | 8.2e-01 | 7.6e-01 | 4.0e-02 |
| 1278 | (REACTOME) Diseases of metabolism | 8.0e-02 | 8.2e-01 | 6.3e-01 | 9.2e-01 | 5.4e-01 | 2.8e-01 |
| 1503 | (REACTOME) Formation of a pool of free 40S subunits | 8.0e-02 | 0.0e+00 | 5.6e-01 | 9.4e-01 | 1.2e-01 | 1.0e-02 |
| 1593 | (REACTOME) The NLRP1 inflammasome | 8.0e-02 | 9.5e-01 | 7.4e-01 | 9.1e-01 | 8.4e-01 | 2.4e-01 |
| 438 | (REACTOME) SCF(Skp2)-mediated degradation of p27/p21 | 8.0e-02 | 1.8e-01 | 7.1e-01 | 8.4e-01 | 2.1e-01 | 3.0e-01 |
| 594 | (REACTOME) Glutamate Neurotransmitter Release Cycle | 8.0e-02 | 7.2e-01 | 9.7e-01 | 8.1e-01 | 2.8e-01 | 5.9e-01 |
| 1365 | (REACTOME) Major pathway of rRNA processing in the nucleolus and cytosol | 8.0e-02 | 0.0e+00 | 0.0e+00 | 3.0e-02 | 0.0e+00 | 0.0e+00 |
| 1400 | (REACTOME) Signaling by MET | 8.0e-02 | 9.7e-01 | 8.3e-01 | 9.7e-01 | 3.3e-01 | 1.2e-01 |
| 1819 | (REACTOME) Interleukin-1 signaling | 8.0e-02 | 2.1e-01 | 9.1e-01 | 9.5e-01 | 3.2e-01 | 4.0e-02 |
| 2042 | (REACTOME) SARS-CoV-1-mediated effects on programmed cell death | 9.0e-02 | 4.7e-01 | 6.3e-01 | 9.1e-01 | 2.7e-01 | 3.0e-01 |
| 2115 | (REACTOME) IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 9.0e-02 | 7.2e-01 | 8.8e-01 | 8.5e-01 | 3.5e-01 | 3.1e-01 |
| 1257 | (REACTOME) Translesion synthesis by POLK | 9.0e-02 | 3.8e-01 | 7.1e-01 | 8.0e-01 | 5.7e-01 | 4.0e-02 |
| 1390 | (REACTOME) TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 9.0e-02 | 5.0e-02 | 7.3e-01 | 1.0e-01 | 3.1e-01 | 8.4e-01 |
| 1651 | (REACTOME) rRNA processing in the nucleus and cytosol | 9.0e-02 | 0.0e+00 | 0.0e+00 | 3.0e-02 | 0.0e+00 | 0.0e+00 |
| 1806 | (REACTOME) Interleukin-33 signaling | 9.0e-02 | 8.4e-01 | 6.0e-01 | 7.8e-01 | 6.1e-01 | 3.7e-01 |
| 2 | (REACTOME) Apoptosis | 9.0e-02 | 5.1e-01 | 7.9e-01 | 9.7e-01 | 1.9e-01 | 8.0e-02 |
| 8 | (REACTOME) Translesion synthesis by REV1 | 9.0e-02 | 3.5e-01 | 7.9e-01 | 8.0e-01 | 5.4e-01 | 5.0e-02 |
| 70 | (REACTOME) Activation of NF-kappaB in B cells | 9.0e-02 | 7.0e-02 | 8.4e-01 | 9.8e-01 | 1.8e-01 | 3.0e-02 |
| 726 | (REACTOME) ECM proteoglycans | 9.0e-02 | 3.3e-01 | 6.2e-01 | 9.4e-01 | 1.7e-01 | 7.0e-02 |
| 1083 | (REACTOME) O-linked glycosylation | 9.0e-02 | 7.8e-01 | 9.1e-01 | 9.4e-01 | 4.5e-01 | 3.0e-02 |
| 1103 | (REACTOME) Toxicity of botulinum toxin type G (botG) | 9.0e-02 | 8.1e-01 | 8.3e-01 | 9.4e-01 | 9.3e-01 | 6.9e-01 |
| 1189 | (REACTOME) Intraflagellar transport | 9.0e-02 | 9.4e-01 | 6.0e-01 | 9.4e-01 | 3.4e-01 | 1.0e+00 |
| 1667 | (REACTOME) Transcriptional regulation by RUNX3 | 9.0e-02 | 4.9e-01 | 7.9e-01 | 9.2e-01 | 1.9e-01 | 3.5e-01 |
| 1694 | (REACTOME) RUNX3 regulates CDKN1A transcription | 9.0e-02 | 5.0e-02 | 8.9e-01 | 7.0e-01 | 2.7e-01 | 4.9e-01 |
| 1915 | (REACTOME) FOXO-mediated transcription of cell cycle genes | 9.0e-02 | 1.7e-01 | 8.5e-01 | 4.8e-01 | 3.1e-01 | 8.0e-02 |
| 1283 | (REACTOME) Constitutive Signaling by AKT1 E17K in Cancer | 1.0e-01 | 6.0e-02 | 9.9e-01 | 3.0e-01 | 2.7e-01 | 1.0e-02 |
| 723 | (REACTOME) Laminin interactions | 1.0e-01 | 7.0e-02 | 6.0e-01 | 9.4e-01 | 8.6e-01 | 2.2e-01 |
| 1499 | (REACTOME) rRNA processing | 1.0e-01 | 0.0e+00 | 0.0e+00 | 3.0e-02 | 0.0e+00 | 0.0e+00 |
| 314 | (REACTOME) Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.0e-01 | 8.9e-01 | 9.2e-01 | 9.1e-01 | 9.1e-01 | 2.0e-01 |
| 2114 | (REACTOME) MyD88 dependent cascade initiated on endosome | 1.0e-01 | 8.9e-01 | 9.2e-01 | 9.1e-01 | 9.1e-01 | 2.0e-01 |
| 522 | (REACTOME) AKT phosphorylates targets in the cytosol | 1.0e-01 | 1.7e-01 | 9.4e-01 | 3.4e-01 | 3.6e-01 | 4.2e-01 |
| 309 | (REACTOME) Toll Like Receptor 9 (TLR9) Cascade | 1.0e-01 | 9.1e-01 | 8.7e-01 | 9.2e-01 | 9.2e-01 | 1.9e-01 |
| 688 | (REACTOME) DNA Damage/Telomere Stress Induced Senescence | 1.1e-01 | 7.0e-02 | 8.3e-01 | 7.8e-01 | 4.9e-01 | 5.2e-01 |
| 222 | (REACTOME) Signaling Pathways | 1.1e-01 | 0.0e+00 | 6.0e-01 | NA | 6.5e-01 | 0.0e+00 |
| 1271 | (REACTOME) Diseases of signal transduction by growth factor receptors and second messengers | 1.1e-01 | 4.9e-01 | 9.4e-01 | 8.5e-01 | 6.0e-01 | 3.6e-01 |
| 1878 | (REACTOME) Nonsense-Mediated Decay (NMD) | 1.1e-01 | 0.0e+00 | 6.0e-01 | 9.0e-01 | 1.7e-01 | 9.0e-02 |
| 2139 | (REACTOME) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.1e-01 | 0.0e+00 | 6.0e-01 | 9.0e-01 | 1.7e-01 | 9.0e-02 |
| 1487 | (REACTOME) Carbohydrate metabolism | 1.1e-01 | 7.3e-01 | 4.2e-01 | 5.7e-01 | 2.4e-01 | 3.0e-02 |
| 961 | (REACTOME) Sphingolipid metabolism | 1.1e-01 | 3.7e-01 | 2.9e-01 | 5.2e-01 | 5.2e-01 | 2.4e-01 |
| 1484 | (REACTOME) Amino acid and derivative metabolism | 1.1e-01 | 0.0e+00 | 4.6e-01 | 0.0e+00 | 4.0e-02 | 0.0e+00 |
| 685 | (REACTOME) Cellular Senescence | 1.1e-01 | 4.3e-01 | 9.6e-01 | 8.4e-01 | 7.7e-01 | 2.4e-01 |
| 2070 | (REACTOME) Signaling by FLT3 fusion proteins | 1.1e-01 | 3.3e-01 | 8.3e-01 | 3.8e-01 | 6.4e-01 | 6.0e-02 |
| 711 | (REACTOME) FCERI mediated NF-kB activation | 1.1e-01 | 1.7e-01 | 8.3e-01 | 1.0e+00 | 2.0e-01 | 4.0e-02 |
| 2138 | (REACTOME) Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.1e-01 | 0.0e+00 | 6.0e-01 | 1.0e+00 | 2.3e-01 | 6.0e-02 |
| 110 | (REACTOME) Cytokine Signaling in Immune system | 1.2e-01 | 1.7e-01 | 7.8e-01 | 8.0e-01 | 4.7e-01 | 3.1e-01 |
| 1767 | (REACTOME) Signaling by Receptor Tyrosine Kinases | 1.2e-01 | 4.8e-01 | 6.0e-01 | 1.0e+00 | 8.1e-01 | 0.0e+00 |
| 2112 | (REACTOME) TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.2e-01 | 8.7e-01 | 9.2e-01 | 9.2e-01 | 8.9e-01 | 1.5e-01 |
| 1211 | (REACTOME) Activation of SMO | 1.2e-01 | 1.2e-01 | 9.6e-01 | 9.0e-01 | 2.9e-01 | 3.3e-01 |
| 1717 | (REACTOME) Cellular responses to stimuli | 1.2e-01 | 0.0e+00 | 6.9e-01 | 8.8e-01 | 1.5e-01 | 1.0e-02 |
| 1116 | (REACTOME) Programmed Cell Death | 1.2e-01 | 6.2e-01 | 8.3e-01 | 9.9e-01 | 2.6e-01 | 1.3e-01 |
| 396 | (REACTOME) Signaling by EGFR | 1.3e-01 | 8.2e-01 | 1.0e+00 | 9.1e-01 | 8.7e-01 | 6.0e-01 |
| 401 | (REACTOME) SRP-dependent cotranslational protein targeting to membrane | 1.3e-01 | 0.0e+00 | 6.0e-01 | 1.0e+00 | 1.7e-01 | 2.0e-02 |
| 1502 | (REACTOME) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 1.3e-01 | 1.0e-02 | 3.3e-01 | 8.5e-01 | 1.6e-01 | 9.0e-02 |
| 1962 | (REACTOME) Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.3e-01 | 5.8e-01 | 9.8e-01 | 8.5e-01 | 3.7e-01 | 4.4e-01 |
| 1966 | (REACTOME) Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.3e-01 | 5.8e-01 | 9.8e-01 | 8.5e-01 | 3.7e-01 | 4.4e-01 |
| 236 | (REACTOME) Glycosaminoglycan metabolism | 1.3e-01 | 2.4e-01 | 2.7e-01 | 5.7e-01 | 2.6e-01 | 0.0e+00 |
| 1509 | (REACTOME) Eukaryotic Translation Termination | 1.3e-01 | 0.0e+00 | 6.0e-01 | 9.8e-01 | 2.1e-01 | 1.0e-02 |
| 256 | (REACTOME) Signaling by EGFR in Cancer | 1.3e-01 | 9.1e-01 | 9.7e-01 | 9.7e-01 | 9.2e-01 | 1.9e-01 |
| 761 | (REACTOME) Defective AMN causes MGA1 | 1.3e-01 | 9.2e-01 | 8.2e-01 | NA | 5.2e-01 | 7.0e-01 |
| 762 | (REACTOME) Defective CUBN causes MGA1 | 1.3e-01 | 9.2e-01 | 8.2e-01 | NA | 5.2e-01 | 7.0e-01 |
| 655 | (REACTOME) Cellular responses to stress | 1.4e-01 | 0.0e+00 | 6.8e-01 | 8.8e-01 | 1.5e-01 | 1.0e-02 |
| 896 | (REACTOME) Muscle contraction | 1.4e-01 | 8.8e-01 | 7.1e-01 | 9.0e-01 | 4.5e-01 | 4.2e-01 |
| 2015 | (REACTOME) Diseases of mitotic cell cycle | 1.4e-01 | 6.1e-01 | 9.1e-01 | 8.5e-01 | 3.6e-01 | 7.6e-01 |
| 2039 | (REACTOME) Aberrant regulation of mitotic cell cycle due to RB1 defects | 1.4e-01 | 6.1e-01 | 9.1e-01 | 8.5e-01 | 3.6e-01 | 7.6e-01 |
| 1716 | (REACTOME) Metabolism of RNA | 1.4e-01 | 0.0e+00 | 0.0e+00 | 9.0e-02 | 0.0e+00 | 0.0e+00 |
| 492 | (REACTOME) Neurophilin interactions with VEGF and VEGFR | 1.4e-01 | 2.0e-02 | 7.3e-01 | 7.8e-01 | 6.9e-01 | 1.0e-02 |
| 1661 | (REACTOME) MET promotes cell motility | 1.4e-01 | 4.4e-01 | 7.3e-01 | 9.5e-01 | 7.2e-01 | 5.1e-01 |
| 1943 | (REACTOME) Wax biosynthesis | 1.4e-01 | 6.5e-01 | 9.8e-01 | 9.9e-01 | 7.8e-01 | 4.0e-01 |
| 50 | (REACTOME) Neurotransmitter uptake and metabolism In glial cells | 1.4e-01 | 8.6e-01 | 8.0e-01 | 9.1e-01 | 7.8e-01 | 7.9e-01 |
| 593 | (REACTOME) Astrocytic Glutamate-Glutamine Uptake And Metabolism | 1.4e-01 | 8.6e-01 | 8.0e-01 | 9.1e-01 | 7.8e-01 | 7.9e-01 |
| 617 | (REACTOME) Dopamine Neurotransmitter Release Cycle | 1.4e-01 | 9.7e-01 | 8.3e-01 | 9.1e-01 | 8.4e-01 | 5.6e-01 |
| 646 | (REACTOME) SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.4e-01 | 8.1e-01 | 9.1e-01 | 9.4e-01 | 1.1e-01 | 5.4e-01 |
| 1875 | (REACTOME) Iron uptake and transport | 1.4e-01 | 5.7e-01 | 8.7e-01 | 9.1e-01 | 3.7e-01 | 7.3e-01 |
| 24 | (REACTOME) BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 1.4e-01 | 8.1e-01 | 7.0e-01 | 8.3e-01 | 4.3e-01 | 7.6e-01 |
| 820 | (REACTOME) Diseases of glycosylation | 1.4e-01 | 8.4e-01 | 6.0e-01 | 9.1e-01 | 3.5e-01 | 1.0e-02 |
| 1668 | (REACTOME) Transcriptional regulation by RUNX2 | 1.4e-01 | 4.4e-01 | 8.9e-01 | 8.5e-01 | 2.5e-01 | 6.1e-01 |
| 903 | (REACTOME) CRMPs in Sema3A signaling | 1.4e-01 | 4.9e-01 | 1.0e+00 | 9.1e-01 | 4.0e-01 | 9.0e-02 |
| 553 | (REACTOME) HS-GAG degradation | 1.4e-01 | 6.7e-01 | 3.2e-01 | 5.6e-01 | 5.2e-01 | 1.0e-01 |
| 199 | (REACTOME) Peptide chain elongation | 1.5e-01 | 0.0e+00 | 6.0e-01 | 1.0e+00 | 2.5e-01 | 2.0e-02 |
| 1457 | (REACTOME) Transcriptional activation of p53 responsive genes | 1.5e-01 | 1.2e-01 | 7.9e-01 | 5.0e-02 | 1.6e-01 | 2.2e-01 |
| 1467 | (REACTOME) Transcriptional activation of cell cycle inhibitor p21 | 1.5e-01 | 1.2e-01 | 7.9e-01 | 5.0e-02 | 1.6e-01 | 2.2e-01 |
| 1505 | (REACTOME) Ribosomal scanning and start codon recognition | 1.5e-01 | 1.0e-02 | 4.6e-01 | 8.5e-01 | 1.7e-01 | 1.4e-01 |
| 888 | (REACTOME) Metabolism of proteins | 1.5e-01 | 0.0e+00 | 5.4e-01 | 8.5e-01 | 1.4e-01 | 0.0e+00 |
| 278 | (REACTOME) MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.6e-01 | 8.5e-01 | 9.2e-01 | 9.4e-01 | 8.9e-01 | 2.7e-01 |
| 310 | (REACTOME) Toll Like Receptor 10 (TLR10) Cascade | 1.6e-01 | 8.1e-01 | 8.7e-01 | 9.2e-01 | 8.4e-01 | 1.1e-01 |
| 312 | (REACTOME) Toll Like Receptor 5 (TLR5) Cascade | 1.6e-01 | 8.1e-01 | 8.7e-01 | 9.2e-01 | 8.4e-01 | 1.1e-01 |
| 313 | (REACTOME) Toll Like Receptor TLR1:TLR2 Cascade | 1.6e-01 | 8.5e-01 | 9.2e-01 | 9.4e-01 | 8.9e-01 | 2.7e-01 |
| 315 | (REACTOME) Toll Like Receptor TLR6:TLR2 Cascade | 1.6e-01 | 8.5e-01 | 9.2e-01 | 9.4e-01 | 8.9e-01 | 2.7e-01 |
| 416 | (REACTOME) Toll Like Receptor 2 (TLR2) Cascade | 1.6e-01 | 8.5e-01 | 9.2e-01 | 9.4e-01 | 8.9e-01 | 2.7e-01 |
| 472 | (REACTOME) Viral mRNA Translation | 1.6e-01 | 0.0e+00 | 6.3e-01 | 1.0e+00 | 2.1e-01 | 1.0e-02 |
| 806 | (REACTOME) Class B/2 (Secretin family receptors) | 1.6e-01 | 1.7e-01 | 5.4e-01 | 9.1e-01 | 3.5e-01 | 1.0e-01 |
| 1465 | (REACTOME) Cell Cycle Checkpoints | 1.6e-01 | 5.0e-02 | 9.5e-01 | 7.8e-01 | 1.7e-01 | 2.5e-01 |
| 1912 | (REACTOME) Transcriptional regulation of granulopoiesis | 1.6e-01 | 4.6e-01 | 8.7e-01 | 3.4e-01 | 3.4e-01 | 8.1e-01 |
| 2131 | (REACTOME) MyD88 cascade initiated on plasma membrane | 1.6e-01 | 8.1e-01 | 8.7e-01 | 9.2e-01 | 8.4e-01 | 1.1e-01 |
| 1337 | (REACTOME) Post-translational protein modification | 1.6e-01 | 3.4e-01 | 6.0e-01 | 8.4e-01 | 2.9e-01 | 4.0e-02 |
| 1866 | (REACTOME) Interferon alpha/beta signaling | 1.6e-01 | 1.0e-02 | 6.0e-01 | 3.0e-01 | 3.4e-01 | 1.1e-01 |
| 56 | (REACTOME) RAF-independent MAPK1/3 activation | 1.6e-01 | 7.8e-01 | 9.1e-01 | 8.1e-01 | 5.4e-01 | 2.5e-01 |
| 1168 | (REACTOME) CLEC7A (Dectin-1) signaling | 1.6e-01 | 3.4e-01 | 8.1e-01 | 1.0e+00 | 6.4e-01 | 1.3e-01 |
| 2020 | (REACTOME) SARS-CoV-1 Infection | 1.6e-01 | 3.3e-01 | 9.7e-01 | 9.4e-01 | 7.6e-01 | 6.2e-01 |
| 1192 | (REACTOME) C-type lectin receptors (CLRs) | 1.6e-01 | 3.7e-01 | 8.6e-01 | 1.0e+00 | 6.4e-01 | 3.1e-01 |
| 629 | (REACTOME) Hyaluronan metabolism | 1.6e-01 | 9.4e-01 | 8.8e-01 | 1.0e+00 | 8.9e-01 | 9.0e-02 |
| 633 | (REACTOME) Hyaluronan uptake and degradation | 1.6e-01 | 9.4e-01 | 8.8e-01 | 1.0e+00 | 8.9e-01 | 9.0e-02 |
| 1098 | (REACTOME) Toxicity of botulinum toxin type B (botB) | 1.6e-01 | 9.9e-01 | 9.7e-01 | 9.4e-01 | 8.4e-01 | 7.3e-01 |
| 2043 | (REACTOME) SARS-CoV-1-host interactions | 1.6e-01 | 1.9e-01 | 8.4e-01 | 9.6e-01 | 7.7e-01 | 7.9e-01 |
| 604 | (REACTOME) Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 1.6e-01 | 9.1e-01 | 1.0e+00 | 9.6e-01 | 3.5e-01 | 9.4e-01 |
| 496 | (REACTOME) Degradation of beta-catenin by the destruction complex | 1.6e-01 | 2.9e-01 | 8.6e-01 | 9.9e-01 | 2.8e-01 | 4.0e-02 |
| 950 | (REACTOME) SLC-mediated transmembrane transport | 1.7e-01 | 6.1e-01 | 7.8e-01 | 1.5e-01 | 4.8e-01 | 2.8e-01 |
| 219 | (REACTOME) Degradation of cysteine and homocysteine | 1.7e-01 | 1.3e-01 | 5.9e-01 | 4.1e-01 | 3.3e-01 | 1.0e-01 |
| 1033 | (REACTOME) HuR (ELAVL1) binds and stabilizes mRNA | 1.7e-01 | 4.7e-01 | 9.1e-01 | 7.8e-01 | 8.9e-01 | 2.4e-01 |
| 902 | (REACTOME) SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.7e-01 | 2.8e-01 | 9.3e-01 | 8.7e-01 | 5.8e-01 | 4.9e-01 |
| 1261 | (REACTOME) Regulation of RAS by GAPs | 1.7e-01 | 1.3e-01 | 7.1e-01 | 1.0e+00 | 1.7e-01 | 4.0e-02 |
| 948 | (REACTOME) Transport of inorganic cations/anions and amino acids/oligopeptides | 1.7e-01 | 1.7e-01 | 9.6e-01 | 1.7e-01 | 4.3e-01 | 4.9e-01 |
| 1050 | (REACTOME) Degradation of AXIN | 1.7e-01 | 5.0e-02 | 6.1e-01 | 9.9e-01 | 2.1e-01 | 8.0e-02 |
| 1300 | (REACTOME) MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.7e-01 | 6.3e-01 | 9.4e-01 | 9.4e-01 | 8.2e-01 | 4.0e-02 |
| 1898 | (REACTOME) Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 1.7e-01 | 4.3e-01 | 8.3e-01 | 9.2e-01 | 5.5e-01 | 1.0e+00 |
| 585 | (REACTOME) NF-kB is activated and signals survival | 1.7e-01 | 3.8e-01 | 9.1e-01 | 8.5e-01 | 6.7e-01 | 4.0e-02 |
| 661 | (REACTOME) Selenocysteine synthesis | 1.7e-01 | 0.0e+00 | 6.3e-01 | 8.1e-01 | 2.4e-01 | 1.0e-02 |
| 1606 | (REACTOME) Wax and plasmalogen biosynthesis | 1.8e-01 | 5.6e-01 | 8.2e-01 | 9.4e-01 | 9.2e-01 | 2.8e-01 |
| 2069 | (REACTOME) STAT5 activation downstream of FLT3 ITD mutants | 1.8e-01 | 1.1e-01 | 6.1e-01 | 3.4e-01 | 3.7e-01 | 2.5e-01 |
| 2157 | (REACTOME) Class I MHC mediated antigen processing & presentation | 1.8e-01 | 4.4e-01 | 8.6e-01 | 7.8e-01 | 3.7e-01 | 0.0e+00 |
| 659 | (REACTOME) Selenoamino acid metabolism | 1.8e-01 | 0.0e+00 | 8.5e-01 | 3.5e-01 | 1.8e-01 | 4.0e-02 |
| 198 | (REACTOME) Eukaryotic Translation Elongation | 1.8e-01 | 0.0e+00 | 6.0e-01 | 1.0e+00 | 2.4e-01 | 1.0e-02 |
| 1895 | (REACTOME) Negative regulation of NOTCH4 signaling | 1.8e-01 | 4.0e-02 | 6.2e-01 | 9.6e-01 | 1.7e-01 | 3.0e-02 |
| 1886 | (REACTOME) IKK complex recruitment mediated by RIP1 | 1.8e-01 | 8.4e-01 | 9.8e-01 | 8.5e-01 | 8.5e-01 | 6.9e-01 |
| 698 | (REACTOME) Acetylcholine Neurotransmitter Release Cycle | 1.8e-01 | 9.1e-01 | 9.0e-01 | 8.0e-01 | 3.4e-01 | 7.2e-01 |
| 1175 | (REACTOME) Cilium Assembly | 1.8e-01 | 5.4e-01 | 4.1e-01 | 1.0e+00 | 2.0e-01 | 8.4e-01 |
| 555 | (REACTOME) Downstream TCR signaling | 1.8e-01 | 2.0e-01 | 8.5e-01 | 1.0e+00 | 2.7e-01 | 3.0e-02 |
| 1471 | (REACTOME) Pyruvate metabolism | 1.8e-01 | 1.5e-01 | 8.5e-01 | 8.5e-01 | 2.8e-01 | 3.1e-01 |
| 188 | (REACTOME) Phase II - Conjugation of compounds | 1.8e-01 | 3.7e-01 | 2.3e-01 | 3.4e-01 | 1.1e-01 | 3.0e-01 |
| 1291 | (REACTOME) Defective CFTR causes cystic fibrosis | 1.8e-01 | 5.0e-02 | 8.3e-01 | 9.9e-01 | 2.2e-01 | 3.0e-02 |
| 71 | (REACTOME) Activation of RAS in B cells | 1.8e-01 | 1.7e-01 | 1.0e+00 | 9.6e-01 | 6.6e-01 | 7.3e-01 |
| 160 | (REACTOME) Degradation of the extracellular matrix | 1.8e-01 | 1.3e-01 | 6.0e-01 | 9.6e-01 | 8.2e-01 | 3.0e-02 |
| 1616 | (REACTOME) Butyrophilin (BTN) family interactions | 1.8e-01 | 7.5e-01 | 7.8e-01 | 3.4e-01 | 6.8e-01 | 1.0e+00 |
| 405 | (REACTOME) Vpu mediated degradation of CD4 | 1.8e-01 | 3.0e-02 | 6.3e-01 | 9.9e-01 | 2.2e-01 | 2.0e-02 |
| 279 | (REACTOME) Sphingolipid de novo biosynthesis | 1.8e-01 | 5.8e-01 | 9.3e-01 | 8.5e-01 | 7.0e-01 | 6.7e-01 |
| 639 | (REACTOME) DAP12 interactions | 1.9e-01 | 6.7e-01 | 9.7e-01 | 9.6e-01 | 3.2e-01 | 3.1e-01 |
| 345 | (REACTOME) Regulation of Apoptosis | 1.9e-01 | 1.0e-01 | 8.0e-01 | 1.0e+00 | 1.4e-01 | 2.0e-02 |
| 1026 | (REACTOME) MAP kinase activation | 1.9e-01 | 9.1e-01 | 9.6e-01 | 9.2e-01 | 8.2e-01 | 7.0e-02 |
| 1397 | (REACTOME) Keratinization | 1.9e-01 | 9.9e-01 | 8.5e-01 | 8.5e-01 | 9.4e-01 | 8.6e-01 |
| 1669 | (REACTOME) Transcriptional regulation by RUNX1 | 1.9e-01 | 8.8e-01 | 8.7e-01 | 1.0e+00 | 5.1e-01 | 7.7e-01 |
| 712 | (REACTOME) POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 1.9e-01 | 1.7e-01 | 9.4e-01 | NA | NA | NA |
| 725 | (REACTOME) Non-integrin membrane-ECM interactions | 1.9e-01 | 1.9e-01 | 8.0e-01 | 9.4e-01 | 5.1e-01 | 3.0e-02 |
| 1021 | (REACTOME) Interleukin-17 signaling | 1.9e-01 | 8.9e-01 | 9.6e-01 | 9.2e-01 | 7.2e-01 | 9.0e-02 |
| 2142 | (REACTOME) GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.0e-01 | 4.0e-02 | 6.3e-01 | 8.2e-01 | 2.0e-01 | 2.0e-02 |
| 554 | (REACTOME) CS/DS degradation | 2.0e-01 | 4.0e-01 | 2.2e-01 | 5.6e-01 | 2.6e-01 | 3.3e-01 |
| 613 | (REACTOME) NOTCH1 Intracellular Domain Regulates Transcription | 2.0e-01 | 7.6e-01 | 6.3e-01 | 9.6e-01 | 6.7e-01 | 9.2e-01 |
| 1501 | (REACTOME) Translation initiation complex formation | 2.0e-01 | 3.0e-02 | 4.1e-01 | 8.5e-01 | 1.9e-01 | 1.7e-01 |
| 365 | (REACTOME) APC/C:Cdc20 mediated degradation of Securin | 2.0e-01 | 2.0e-02 | 7.8e-01 | 1.0e+00 | 1.7e-01 | 0.0e+00 |
| 780 | (REACTOME) Metabolism of polyamines | 2.1e-01 | 4.0e-02 | 6.0e-01 | 7.8e-01 | 2.0e-01 | 3.0e-02 |
| 1085 | (REACTOME) Mitophagy | 2.1e-01 | 3.4e-01 | 8.0e-01 | 8.5e-01 | 3.1e-01 | 4.0e-02 |
| 782 | (REACTOME) Amino acid transport across the plasma membrane | 2.1e-01 | 4.3e-01 | 6.0e-01 | 3.6e-01 | 2.5e-01 | 2.3e-01 |
| 2156 | (REACTOME) Antigen processing: Ubiquitination & Proteasome degradation | 2.1e-01 | 3.3e-01 | 8.7e-01 | 7.8e-01 | 4.0e-01 | 0.0e+00 |
| 1148 | (REACTOME) Cardiac conduction | 2.2e-01 | 7.3e-01 | 9.0e-01 | 8.5e-01 | 4.8e-01 | 3.3e-01 |
| 1166 | (REACTOME) Dectin-1 mediated noncanonical NF-kB signaling | 2.2e-01 | 7.0e-02 | 6.4e-01 | 9.8e-01 | 4.3e-01 | 3.0e-02 |
| 1420 | (REACTOME) Assembly of the pre-replicative complex | 2.2e-01 | 4.0e-02 | 9.0e-01 | 9.4e-01 | 1.5e-01 | 0.0e+00 |
| 1680 | (REACTOME) RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.2e-01 | 1.7e-01 | 6.4e-01 | 1.0e+00 | 2.8e-01 | 1.2e-01 |
| 1871 | (REACTOME) Interferon Signaling | 2.2e-01 | 6.4e-01 | 6.0e-01 | 3.1e-01 | 6.0e-01 | 5.3e-01 |
| 362 | (REACTOME) Autodegradation of Cdh1 by Cdh1:APC/C | 2.2e-01 | 2.0e-02 | 7.0e-01 | 1.0e+00 | 2.0e-01 | 0.0e+00 |
| 400 | (REACTOME) GRB2 events in EGFR signaling | 2.2e-01 | 8.5e-01 | 9.0e-01 | 8.5e-01 | 9.2e-01 | 5.9e-01 |
| 426 | (REACTOME) Organelle biogenesis and maintenance | 2.2e-01 | 5.6e-01 | 6.0e-01 | 9.4e-01 | 3.6e-01 | 2.4e-01 |
| 1528 | (REACTOME) DNA Damage Bypass | 2.3e-01 | 6.3e-01 | 7.3e-01 | 9.1e-01 | 7.2e-01 | 2.4e-01 |
| 1316 | (REACTOME) CD22 mediated BCR regulation | 2.3e-01 | 8.8e-01 | 8.6e-01 | 8.5e-01 | 6.3e-01 | 3.6e-01 |
| 128 | (REACTOME) Transcription of E2F targets under negative control by DREAM complex | 2.3e-01 | 9.7e-01 | 6.4e-01 | 9.5e-01 | 4.5e-01 | 7.5e-01 |
| 281 | (REACTOME) MyD88-independent TLR4 cascade | 2.3e-01 | 6.2e-01 | 9.7e-01 | 8.8e-01 | 3.7e-01 | 2.6e-01 |
| 379 | (REACTOME) Assembly Of The HIV Virion | 2.3e-01 | 5.8e-01 | 8.5e-01 | 9.6e-01 | 5.8e-01 | 3.1e-01 |
| 1172 | (REACTOME) GLI3 is processed to GLI3R by the proteasome | 2.3e-01 | 5.0e-02 | 7.1e-01 | 9.9e-01 | 2.1e-01 | 1.0e-02 |
| 1287 | (REACTOME) NIK–>noncanonical NF-kB signaling | 2.3e-01 | 5.0e-02 | 6.5e-01 | 9.8e-01 | 4.3e-01 | 3.0e-02 |
| 1887 | (REACTOME) IRAK2 mediated activation of TAK1 complex | 2.3e-01 | 5.4e-01 | 9.2e-01 | 8.5e-01 | 3.2e-01 | 7.0e-02 |
| 1888 | (REACTOME) TRIF(TICAM1)-mediated TLR4 signaling | 2.3e-01 | 6.2e-01 | 9.7e-01 | 8.8e-01 | 3.7e-01 | 2.6e-01 |
| 605 | (REACTOME) Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.3e-01 | 5.0e-02 | 7.1e-01 | 1.0e+00 | 2.2e-01 | 3.0e-02 |
| 10 | (REACTOME) Recognition of DNA damage by PCNA-containing replication complex | 2.3e-01 | 3.8e-01 | 6.0e-01 | 8.5e-01 | 6.9e-01 | 1.8e-01 |
| 1031 | (REACTOME) AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.3e-01 | 6.0e-02 | 6.0e-01 | 9.5e-01 | 1.7e-01 | 6.0e-02 |
| 1130 | (REACTOME) Hh mutants are degraded by ERAD | 2.3e-01 | 1.0e-01 | 6.8e-01 | 9.9e-01 | 1.7e-01 | 2.0e-02 |
| 1504 | (REACTOME) Formation of the ternary complex, and subsequently, the 43S complex | 2.3e-01 | 4.0e-02 | 6.0e-01 | 8.5e-01 | 2.0e-01 | 7.0e-02 |
| 1703 | (REACTOME) Regulation of PTEN stability and activity | 2.3e-01 | 6.0e-02 | 6.0e-01 | 1.0e+00 | 2.3e-01 | 4.0e-02 |
| 556 | (REACTOME) Phosphorylation of CD3 and TCR zeta chains | 2.3e-01 | 8.1e-01 | 9.4e-01 | 9.4e-01 | 9.7e-01 | 2.8e-01 |
| 574 | (REACTOME) COPII-mediated vesicle transport | 2.3e-01 | 4.7e-01 | 9.6e-01 | 8.3e-01 | 2.2e-01 | 2.0e-02 |
| 1460 | (REACTOME) Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 2.3e-01 | 4.0e-02 | 6.0e-01 | 9.4e-01 | 2.1e-01 | 2.0e-02 |
| 1461 | (REACTOME) p53-Independent DNA Damage Response | 2.3e-01 | 4.0e-02 | 6.0e-01 | 9.4e-01 | 2.1e-01 | 2.0e-02 |
| 1462 | (REACTOME) p53-Independent G1/S DNA damage checkpoint | 2.3e-01 | 4.0e-02 | 6.0e-01 | 9.4e-01 | 2.1e-01 | 2.0e-02 |
| 1086 | (REACTOME) PINK1-PRKN Mediated Mitophagy | 2.3e-01 | 3.8e-01 | 8.5e-01 | 8.8e-01 | 3.1e-01 | 4.0e-02 |
| 89 | (REACTOME) Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.4e-01 | 4.0e-02 | 6.0e-01 | 1.0e+00 | 2.0e-01 | 3.0e-02 |
| 1903 | (REACTOME) Autophagy | 2.4e-01 | 3.1e-01 | 7.3e-01 | 8.7e-01 | 4.2e-01 | 1.0e-02 |
| 69 | (REACTOME) Downstream signaling events of B Cell Receptor (BCR) | 2.4e-01 | 4.8e-01 | 8.9e-01 | 1.0e+00 | 3.4e-01 | 4.0e-02 |
| 193 | (REACTOME) Glutathione conjugation | 2.4e-01 | 3.7e-01 | 7.1e-01 | 9.0e-01 | 4.9e-01 | 9.9e-01 |
| 339 | (REACTOME) Clostridium neurotoxicity | 2.4e-01 | 9.4e-01 | 9.7e-01 | 9.0e-01 | 3.5e-01 | 9.6e-01 |
| 375 | (REACTOME) Membrane binding and targetting of GAG proteins | 2.4e-01 | 5.8e-01 | 8.5e-01 | 9.5e-01 | 6.4e-01 | 1.7e-01 |
| 376 | (REACTOME) Synthesis And Processing Of GAG, GAGPOL Polyproteins | 2.4e-01 | 5.8e-01 | 8.5e-01 | 9.5e-01 | 6.4e-01 | 1.7e-01 |
| 378 | (REACTOME) Lipoprotein metabolism | 2.4e-01 | 7.4e-01 | 9.0e-01 | 9.4e-01 | 5.5e-01 | 6.9e-01 |
| 901 | (REACTOME) Sema3A PAK dependent Axon repulsion | 2.4e-01 | 2.5e-01 | 6.0e-01 | 8.5e-01 | 8.7e-01 | 1.1e-01 |
| 1119 | (REACTOME) Hedgehog ligand biogenesis | 2.4e-01 | 1.9e-01 | 7.8e-01 | 9.2e-01 | 2.2e-01 | 5.0e-02 |
| 1162 | (REACTOME) MyD88 deficiency (TLR5) | 2.4e-01 | 8.2e-01 | 8.1e-01 | 9.5e-01 | 8.7e-01 | 6.8e-01 |
| 1186 | (REACTOME) VxPx cargo-targeting to cilium | 2.4e-01 | 3.5e-01 | 8.5e-01 | 9.4e-01 | 9.8e-01 | 5.6e-01 |
| 1296 | (REACTOME) MAPK family signaling cascades | 2.4e-01 | 8.7e-01 | 9.0e-01 | 9.4e-01 | 5.4e-01 | 4.0e-01 |
| 1450 | (REACTOME) Cell Cycle, Mitotic | 2.4e-01 | 4.8e-01 | 9.1e-01 | 9.1e-01 | 5.1e-01 | 1.1e-01 |
| 1744 | (REACTOME) Glutamate and glutamine metabolism | 2.4e-01 | 8.3e-01 | 7.3e-01 | 9.3e-01 | 8.5e-01 | 6.0e-01 |
| 1889 | (REACTOME) TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.4e-01 | 7.7e-01 | 8.8e-01 | 9.1e-01 | 4.2e-01 | 3.1e-01 |
| 1922 | (REACTOME) LXRs regulate gene expression linked to gluconeogenesis | 2.4e-01 | 9.5e-01 | 7.9e-01 | 9.0e-01 | 6.6e-01 | 4.6e-01 |
| 441 | (REACTOME) Digestion of dietary carbohydrate | 2.4e-01 | 4.4e-01 | 8.3e-01 | 9.4e-01 | NA | NA |
| 1480 | (REACTOME) Lysine catabolism | 2.4e-01 | 6.7e-01 | 8.6e-01 | 9.1e-01 | 9.9e-01 | 1.0e+00 |
| 1822 | (REACTOME) Interleukin-21 signaling | 2.4e-01 | 8.3e-01 | 9.0e-01 | 9.4e-01 | 3.2e-01 | 5.7e-01 |
| 1817 | (REACTOME) Interleukin-2 signaling | 2.4e-01 | 9.1e-01 | 9.2e-01 | 9.6e-01 | 2.3e-01 | 3.7e-01 |
| 2079 | (REACTOME) Negative regulation of FLT3 | 2.4e-01 | 9.2e-01 | 9.5e-01 | 8.2e-01 | 7.9e-01 | 3.1e-01 |
| 93 | (REACTOME) ER-Phagosome pathway | 2.4e-01 | 2.3e-01 | 7.6e-01 | 9.6e-01 | 2.9e-01 | 1.1e-01 |
| 809 | (REACTOME) Semaphorin interactions | 2.5e-01 | 4.5e-01 | 7.5e-01 | 9.4e-01 | 7.2e-01 | 2.8e-01 |
| 1428 | (REACTOME) Orc1 removal from chromatin | 2.5e-01 | 5.0e-02 | 9.6e-01 | 9.4e-01 | 1.7e-01 | 5.0e-02 |
| 1673 | (REACTOME) Regulation of RUNX1 Expression and Activity | 2.5e-01 | 1.3e-01 | 7.1e-01 | 3.4e-01 | 6.7e-01 | 3.6e-01 |
| 1758 | (REACTOME) Interleukin-9 signaling | 2.5e-01 | 9.5e-01 | 9.0e-01 | 9.1e-01 | 2.7e-01 | 5.7e-01 |
| 363 | (REACTOME) SCF-beta-TrCP mediated degradation of Emi1 | 2.5e-01 | 4.0e-02 | 6.0e-01 | 9.6e-01 | 2.5e-01 | 1.0e-02 |
| 835 | (REACTOME) Clearance of seratonin | 2.5e-01 | 6.7e-01 | 6.3e-01 | 1.0e+00 | 8.6e-01 | 6.8e-01 |
| 941 | (REACTOME) Nectin/Necl trans heterodimerization | 2.5e-01 | 9.9e-01 | 5.8e-01 | 9.4e-01 | 6.1e-01 | 4.4e-01 |
| 1301 | (REACTOME) ERK1/ERK2 pathway | 2.5e-01 | 9.1e-01 | 6.3e-01 | 9.6e-01 | 6.3e-01 | 7.2e-01 |
| 1710 | (REACTOME) Neddylation | 2.5e-01 | 5.0e-02 | 9.0e-01 | 7.9e-01 | 3.7e-01 | 0.0e+00 |
| 1957 | (REACTOME) Signaling by MAPK mutants | 2.5e-01 | 7.6e-01 | 7.8e-01 | 5.5e-01 | 4.5e-01 | 5.0e-02 |
| 111 | (REACTOME) Adaptive Immune System | 2.5e-01 | 4.8e-01 | 9.3e-01 | 8.5e-01 | 6.4e-01 | 7.0e-02 |
| 1272 | (REACTOME) Infectious disease | 2.5e-01 | 2.3e-01 | 9.2e-01 | 1.0e+00 | 7.4e-01 | 5.0e-01 |
| 385 | (REACTOME) Regulation of APC/C activators between G1/S and early anaphase | 2.5e-01 | 6.0e-02 | 8.1e-01 | 9.9e-01 | 2.7e-01 | 0.0e+00 |
| 1696 | (REACTOME) Regulation of RUNX3 expression and activity | 2.5e-01 | 8.0e-02 | 6.5e-01 | 9.9e-01 | 1.9e-01 | 4.0e-02 |
| 1340 | (REACTOME) Inflammasomes | 2.6e-01 | 6.6e-01 | 9.3e-01 | 9.1e-01 | 7.8e-01 | 5.2e-01 |
| 1829 | (REACTOME) MECP2 regulates transcription factors | 2.6e-01 | 4.8e-01 | 8.7e-01 | 9.1e-01 | 8.2e-01 | 8.4e-01 |
| 1872 | (REACTOME) O-linked glycosylation of mucins | 2.6e-01 | 7.4e-01 | 6.9e-01 | 9.0e-01 | 9.8e-01 | 2.9e-01 |
| 881 | (REACTOME) Diseases associated with O-glycosylation of proteins | 2.6e-01 | 8.1e-01 | 6.3e-01 | 9.9e-01 | 2.8e-01 | 8.0e-02 |
| 528 | (REACTOME) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 2.6e-01 | 9.8e-01 | 6.4e-01 | 9.2e-01 | 8.9e-01 | 2.0e-02 |
| 1171 | (REACTOME) Degradation of GLI2 by the proteasome | 2.6e-01 | 7.0e-02 | 7.1e-01 | 9.9e-01 | 2.1e-01 | 1.0e-02 |
| 1799 | (REACTOME) Signaling by NOTCH4 | 2.6e-01 | 2.3e-01 | 7.0e-01 | 9.9e-01 | 2.7e-01 | 3.6e-01 |
| 1951 | (REACTOME) Response of EIF2AK1 (HRI) to heme deficiency | 2.6e-01 | 7.2e-01 | 6.0e-01 | 8.7e-01 | 4.6e-01 | 1.0e+00 |
| 2033 | (REACTOME) Maturation of protein E_1 | 2.6e-01 | 4.6e-01 | 9.2e-01 | 6.3e-01 | 6.4e-01 | 1.3e-01 |
| 2049 | (REACTOME) Maturation of protein E_2 | 2.6e-01 | 4.6e-01 | 9.2e-01 | 6.3e-01 | 6.4e-01 | 1.3e-01 |
| 2092 | (REACTOME) Cellular response to starvation | 2.6e-01 | 0.0e+00 | 8.7e-01 | 9.4e-01 | 4.1e-01 | 4.0e-02 |
| 1206 | (REACTOME) Ligand-receptor interactions | 2.6e-01 | 1.2e-01 | 9.7e-01 | 9.0e-01 | 4.2e-01 | 2.1e-01 |
| 1945 | (REACTOME) ALPK1 signaling pathway | 2.6e-01 | 9.0e-01 | 9.6e-01 | 8.5e-01 | 4.7e-01 | 2.7e-01 |
| 1664 | (REACTOME) InlA-mediated entry of Listeria monocytogenes into host cells | 2.6e-01 | 8.7e-01 | 9.7e-01 | 7.3e-01 | 9.4e-01 | 5.3e-01 |
| 316 | (REACTOME) Innate Immune System | 2.7e-01 | 3.3e-01 | 9.4e-01 | 1.0e+00 | 4.5e-01 | 4.2e-01 |
| 218 | (REACTOME) Sulfide oxidation to sulfate | 2.7e-01 | 3.7e-01 | 3.1e-01 | 4.1e-01 | 1.4e-01 | 4.0e-02 |
| 366 | (REACTOME) APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 2.7e-01 | 4.0e-02 | 6.0e-01 | 1.0e+00 | 1.7e-01 | 1.0e-02 |
| 775 | (REACTOME) Autodegradation of the E3 ubiquitin ligase COP1 | 2.7e-01 | 3.0e-02 | 7.3e-01 | 1.0e+00 | 1.7e-01 | 2.0e-02 |
| 1212 | (REACTOME) GLI proteins bind promoters of Hh responsive genes to promote transcription | 2.7e-01 | 3.4e-01 | 9.9e-01 | 1.0e+00 | 7.2e-01 | 5.1e-01 |
| 1798 | (REACTOME) NOTCH3 Intracellular Domain Regulates Transcription | 2.7e-01 | 3.8e-01 | 7.3e-01 | 3.3e-01 | 6.1e-01 | 1.5e-01 |
| 1681 | (REACTOME) RUNX1 regulates transcription of genes involved in differentiation of keratinocytes | 2.8e-01 | 3.4e-01 | 6.0e-01 | 1.0e+00 | 6.0e-01 | 8.1e-01 |
| 389 | (REACTOME) Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.8e-01 | 5.0e-02 | 8.5e-01 | 1.0e+00 | 2.1e-01 | 1.0e-02 |
| 607 | (REACTOME) Biological oxidations | 2.8e-01 | 4.9e-01 | 3.5e-01 | 4.8e-01 | 1.0e-01 | 2.2e-01 |
| 1449 | (REACTOME) G2/M Transition | 2.8e-01 | 2.8e-01 | 8.3e-01 | 8.4e-01 | 4.0e-01 | 2.4e-01 |
| 252 | (REACTOME) Heparan sulfate/heparin (HS-GAG) metabolism | 2.8e-01 | 4.8e-01 | 4.0e-01 | 5.2e-01 | 2.8e-01 | 6.0e-02 |
| 777 | (REACTOME) Regulation of ornithine decarboxylase (ODC) | 2.8e-01 | 5.0e-02 | 6.0e-01 | 8.5e-01 | 2.4e-01 | 4.0e-02 |
| 1456 | (REACTOME) Stabilization of p53 | 2.8e-01 | 1.0e-01 | 8.5e-01 | 9.4e-01 | 2.1e-01 | 3.0e-02 |
| 669 | (REACTOME) Fc epsilon receptor (FCERI) signaling | 2.8e-01 | 5.0e-01 | 9.7e-01 | 1.0e+00 | 4.7e-01 | 3.2e-01 |
| 1455 | (REACTOME) G2/M Checkpoints | 2.8e-01 | 2.1e-01 | 8.8e-01 | 8.5e-01 | 2.7e-01 | 1.7e-01 |
| 1728 | (REACTOME) Digestion and absorption | 2.8e-01 | 9.2e-01 | 9.8e-01 | 9.5e-01 | 2.2e-01 | 5.4e-01 |
| 1163 | (REACTOME) IkBA variant leads to EDA-ID | 2.8e-01 | 7.1e-01 | 9.3e-01 | 9.5e-01 | 8.4e-01 | 6.8e-01 |
| 1281 | (REACTOME) RAF/MAP kinase cascade | 2.8e-01 | 9.0e-01 | 6.0e-01 | 9.7e-01 | 6.0e-01 | 7.1e-01 |
| 406 | (REACTOME) Vif-mediated degradation of APOBEC3G | 2.8e-01 | 1.0e-01 | 6.4e-01 | 1.0e+00 | 1.6e-01 | 1.0e-02 |
| 1042 | (REACTOME) Mitotic G2-G2/M phases | 2.8e-01 | 3.0e-01 | 8.3e-01 | 8.4e-01 | 4.1e-01 | 2.4e-01 |
| 1860 | (REACTOME) Signaling by NTRK3 (TRKC) | 2.8e-01 | 7.3e-01 | 9.9e-01 | 9.9e-01 | 2.7e-01 | 7.9e-01 |
| 4 | (REACTOME) Intrinsic Pathway for Apoptosis | 2.8e-01 | 7.1e-01 | 9.6e-01 | 8.5e-01 | 4.6e-01 | 1.7e-01 |
| 357 | (REACTOME) Binding and entry of HIV virion | 2.8e-01 | 0.0e+00 | 9.9e-01 | 9.4e-01 | 9.9e-01 | 1.5e-01 |
| 221 | (REACTOME) Sulfur amino acid metabolism | 2.8e-01 | 2.0e-01 | 4.2e-01 | 1.0e-01 | 4.1e-01 | 4.0e-02 |
| 935 | (REACTOME) Adherens junctions interactions | 2.8e-01 | 3.6e-01 | 8.8e-01 | 9.0e-01 | 8.3e-01 | 3.5e-01 |
| 1883 | (REACTOME) Ion transport by P-type ATPases | 2.8e-01 | 4.3e-01 | 7.3e-01 | 3.4e-01 | 7.2e-01 | 6.6e-01 |
| 1277 | (REACTOME) RHO GTPases Activate NADPH Oxidases | 2.8e-01 | 3.4e-01 | 8.7e-01 | 9.1e-01 | 5.2e-01 | 8.5e-01 |
| 1433 | (REACTOME) Switching of origins to a post-replicative state | 2.9e-01 | 1.0e-02 | 9.1e-01 | 9.2e-01 | 1.7e-01 | 3.0e-02 |
| 367 | (REACTOME) Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.9e-01 | 5.0e-02 | 8.5e-01 | 1.0e+00 | 2.1e-01 | 1.0e-02 |
| 225 | (REACTOME) Budding and maturation of HIV virion | 2.9e-01 | 4.7e-01 | 8.0e-01 | 9.6e-01 | 6.1e-01 | 1.1e-01 |
| 340 | (REACTOME) Toll-like Receptor Cascades | 2.9e-01 | 1.3e-01 | 7.0e-01 | 9.0e-01 | 3.4e-01 | 6.9e-01 |
| 1373 | (REACTOME) Metal sequestration by antimicrobial proteins | 2.9e-01 | NA | 9.7e-01 | 8.5e-01 | 8.4e-01 | 8.6e-01 |
| 557 | (REACTOME) Translocation of ZAP-70 to Immunological synapse | 2.9e-01 | 3.3e-01 | 9.9e-01 | 1.0e+00 | 8.9e-01 | 9.5e-01 |
| 241 | (REACTOME) Macroautophagy | 2.9e-01 | 3.7e-01 | 8.3e-01 | 9.0e-01 | 5.5e-01 | 1.0e-02 |
| 338 | (REACTOME) Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 2.9e-01 | 8.1e-01 | 9.7e-01 | 9.9e-01 | 7.5e-01 | 4.1e-01 |
| 361 | (REACTOME) APC/C:Cdc20 mediated degradation of Cyclin B | 2.9e-01 | 3.4e-01 | 9.8e-01 | 8.7e-01 | 6.4e-01 | 5.0e-02 |
| 399 | (REACTOME) APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 2.9e-01 | 5.0e-02 | 8.5e-01 | 1.0e+00 | 2.0e-01 | 1.0e-02 |
| 524 | (REACTOME) Nuclear Events (kinase and transcription factor activation) | 2.9e-01 | 5.2e-01 | 6.0e-01 | 8.4e-01 | 8.5e-01 | 4.5e-01 |
| 851 | (REACTOME) ABC-family proteins mediated transport | 2.9e-01 | 1.0e-01 | 8.5e-01 | 9.5e-01 | 2.0e-01 | 2.0e-02 |
| 1614 | (REACTOME) PTK6 Activates STAT3 | 2.9e-01 | 6.4e-01 | 6.1e-01 | 8.5e-01 | 7.6e-01 | 7.1e-01 |
| 1754 | (REACTOME) OAS antiviral response | 2.9e-01 | 3.4e-01 | 9.9e-01 | 8.5e-01 | 8.8e-01 | 7.3e-01 |
| 1804 | (REACTOME) TICAM1,TRAF6-dependent induction of TAK1 complex | 2.9e-01 | 8.8e-01 | 6.2e-01 | 7.9e-01 | 4.8e-01 | 1.4e-01 |
| 458 | (REACTOME) Oligomerization of connexins into connexons | 2.9e-01 | 4.3e-01 | 8.5e-01 | 8.5e-01 | NA | 5.1e-01 |
| 460 | (REACTOME) Gap junction assembly | 2.9e-01 | 4.3e-01 | 8.5e-01 | 8.5e-01 | NA | 5.1e-01 |
| 1084 | (REACTOME) O-glycosylation of TSR domain-containing proteins | 2.9e-01 | 1.7e-01 | 6.0e-01 | 9.4e-01 | 2.3e-01 | 5.0e-02 |
| 1432 | (REACTOME) CDK-mediated phosphorylation and removal of Cdc6 | 2.9e-01 | 7.0e-02 | 7.1e-01 | 9.6e-01 | 1.9e-01 | 4.0e-02 |
| 176 | (REACTOME) Glycerophospholipid biosynthesis | 2.9e-01 | 1.0e-01 | 8.3e-01 | 7.8e-01 | 2.9e-01 | 6.0e-01 |
| 1906 | (REACTOME) FOXO-mediated transcription | 3.0e-01 | 4.8e-01 | 9.2e-01 | 7.8e-01 | 3.8e-01 | 1.3e-01 |
| 94 | (REACTOME) Antigen processing-Cross presentation | 3.0e-01 | 4.3e-01 | 8.3e-01 | 9.8e-01 | 3.1e-01 | 3.3e-01 |
| 930 | (REACTOME) G alpha (z) signalling events | 3.0e-01 | 6.5e-01 | 1.0e+00 | 9.0e-01 | 8.3e-01 | 3.3e-01 |
| 1078 | (REACTOME) Defective B3GALTL causes PpS | 3.0e-01 | 1.8e-01 | 6.0e-01 | 9.4e-01 | 1.7e-01 | 9.0e-02 |
| 404 | (REACTOME) SHC1 events in EGFR signaling | 3.0e-01 | 9.7e-01 | 8.8e-01 | 8.5e-01 | 9.1e-01 | 7.5e-01 |
| 575 | (REACTOME) Regulation of pyruvate dehydrogenase (PDH) complex | 3.0e-01 | 3.8e-01 | 9.6e-01 | 8.5e-01 | 4.4e-01 | 2.9e-01 |
| 420 | (REACTOME) Cytosolic sensors of pathogen-associated DNA | 3.0e-01 | 7.6e-01 | 8.9e-01 | 9.3e-01 | 8.6e-01 | 5.0e-02 |
| 662 | (REACTOME) DAP12 signaling | 3.0e-01 | 7.6e-01 | 9.7e-01 | 9.5e-01 | 2.6e-01 | 3.9e-01 |
| 1382 | (REACTOME) TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.0e-01 | 5.6e-01 | 9.0e-01 | 8.5e-01 | 2.5e-01 | 2.0e-02 |
| 1431 | (REACTOME) DNA Replication Pre-Initiation | 3.0e-01 | 3.0e-02 | 9.7e-01 | 9.1e-01 | 2.0e-01 | 2.0e-02 |
| 386 | (REACTOME) APC/C:Cdc20 mediated degradation of mitotic proteins | 3.0e-01 | 4.0e-02 | 8.5e-01 | 1.0e+00 | 2.6e-01 | 1.0e-02 |
| 552 | (REACTOME) TCR signaling | 3.0e-01 | 2.7e-01 | 9.9e-01 | 1.0e+00 | 3.3e-01 | 2.5e-01 |
| 1380 | (REACTOME) Oncogenic MAPK signaling | 3.0e-01 | 9.2e-01 | 9.1e-01 | 9.6e-01 | 4.8e-01 | 4.7e-01 |
| 1739 | (REACTOME) Plasma lipoprotein clearance | 3.0e-01 | 7.2e-01 | 9.6e-01 | 8.1e-01 | 9.6e-01 | 9.0e-01 |
| 547 | (REACTOME) Keratan sulfate degradation | 3.0e-01 | 6.1e-01 | 4.4e-01 | 4.1e-01 | 4.3e-01 | 1.8e-01 |
| 185 | (REACTOME) Cell-Cell communication | 3.1e-01 | 3.8e-01 | 9.0e-01 | 9.4e-01 | 9.6e-01 | 1.1e-01 |
| 1306 | (REACTOME) MAPK6/MAPK4 signaling | 3.1e-01 | 3.3e-01 | 6.2e-01 | 9.2e-01 | 1.7e-01 | 1.0e-02 |
| 1608 | (REACTOME) PTK6 Regulates Proteins Involved in RNA Processing | 3.1e-01 | 1.0e-01 | 8.5e-01 | 9.0e-01 | 7.3e-01 | 2.4e-01 |
| 1982 | (REACTOME) Pexophagy | 3.1e-01 | 4.3e-01 | 7.6e-01 | 9.2e-01 | 3.5e-01 | 1.3e-01 |
| 364 | (REACTOME) APC/C-mediated degradation of cell cycle proteins | 3.1e-01 | 4.0e-02 | 6.0e-01 | 1.0e+00 | 2.7e-01 | 0.0e+00 |
| 1043 | (REACTOME) Regulation of mitotic cell cycle | 3.1e-01 | 4.0e-02 | 6.0e-01 | 1.0e+00 | 2.7e-01 | 0.0e+00 |
| 1355 | (REACTOME) Interleukin-10 signaling | 3.1e-01 | 7.7e-01 | 9.3e-01 | 9.6e-01 | 7.8e-01 | 0.0e+00 |
| 1016 | (REACTOME) Cell junction organization | 3.1e-01 | 2.3e-01 | 8.7e-01 | 7.8e-01 | 9.2e-01 | 2.2e-01 |
| 9 | (REACTOME) Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | 3.1e-01 | 6.6e-01 | 8.3e-01 | 8.7e-01 | 8.1e-01 | 2.3e-01 |
| 187 | (REACTOME) G0 and Early G1 | 3.1e-01 | 1.0e+00 | 6.1e-01 | 9.1e-01 | 6.3e-01 | 1.0e+00 |
| 1548 | (REACTOME) Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 3.1e-01 | 8.2e-01 | 9.1e-01 | 9.4e-01 | 3.5e-01 | 1.0e-01 |
| 2143 | (REACTOME) Regulation of NPAS4 gene expression | 3.1e-01 | 4.6e-01 | 1.0e+00 | 8.4e-01 | 7.9e-01 | 4.3e-01 |
| 99 | (REACTOME) Erythrocytes take up oxygen and release carbon dioxide | 3.1e-01 | 8.1e-01 | 8.5e-01 | 9.5e-01 | 9.8e-01 | 9.8e-01 |
| 292 | (REACTOME) NGF processing | 3.1e-01 | 9.8e-01 | 8.0e-01 | 7.8e-01 | 3.4e-01 | 8.2e-01 |
| 436 | (REACTOME) Signaling by NTRK1 (TRKA) | 3.1e-01 | 6.4e-01 | 6.0e-01 | 9.7e-01 | 3.7e-01 | 4.3e-01 |
| 519 | (REACTOME) Signaling by NOTCH1 | 3.1e-01 | 1.7e-01 | 6.2e-01 | 8.5e-01 | 8.9e-01 | 6.1e-01 |
| 916 | (REACTOME) SUMOylation of intracellular receptors | 3.1e-01 | 9.8e-01 | 9.7e-01 | 9.2e-01 | 6.5e-01 | 6.8e-01 |
| 926 | (REACTOME) cGMP effects | 3.1e-01 | 8.3e-01 | 8.7e-01 | 5.1e-01 | 6.1e-01 | 9.7e-01 |
| 1051 | (REACTOME) Degradation of DVL | 3.1e-01 | 7.0e-02 | 8.7e-01 | 9.9e-01 | 2.5e-01 | 2.0e-02 |
| 1053 | (REACTOME) Regulation of FZD by ubiquitination | 3.1e-01 | 9.1e-01 | 8.1e-01 | 7.9e-01 | 6.5e-01 | 6.4e-01 |
| 1136 | (REACTOME) Hh mutants abrogate ligand secretion | 3.1e-01 | 1.1e-01 | 7.8e-01 | 9.8e-01 | 1.7e-01 | 3.0e-02 |
| 1305 | (REACTOME) Regulation of TLR by endogenous ligand | 3.1e-01 | 5.0e-02 | 7.1e-01 | 9.4e-01 | 6.6e-01 | 2.9e-01 |
| 1333 | (REACTOME) Gap-filling DNA repair synthesis and ligation in GG-NER | 3.1e-01 | 4.4e-01 | 6.1e-01 | 8.0e-01 | 8.6e-01 | 2.3e-01 |
| 1626 | (REACTOME) FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.1e-01 | 5.0e-02 | 6.0e-01 | 9.6e-01 | 3.4e-01 | 5.0e-02 |
| 1864 | (REACTOME) Expression and Processing of Neurotrophins | 3.1e-01 | 9.8e-01 | 8.0e-01 | 7.8e-01 | 3.4e-01 | 8.2e-01 |
| 1874 | (REACTOME) Endosomal Sorting Complex Required For Transport (ESCRT) | 3.1e-01 | 4.7e-01 | 8.1e-01 | 9.6e-01 | 3.4e-01 | 4.0e-02 |
| 2135 | (REACTOME) Gastrulation | 3.1e-01 | 1.7e-01 | 9.7e-01 | 8.3e-01 | 7.3e-01 | 9.9e-01 |
| 403 | (REACTOME) GAB1 signalosome | 3.1e-01 | 9.0e-01 | 9.4e-01 | 9.4e-01 | 6.5e-01 | 5.4e-01 |
| 1008 | (REACTOME) Asparagine N-linked glycosylation | 3.1e-01 | 4.7e-01 | 9.9e-01 | 9.0e-01 | 1.9e-01 | 2.0e-02 |
| 1348 | (REACTOME) Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3.1e-01 | 1.7e-01 | 6.0e-01 | 9.4e-01 | 4.3e-01 | 2.0e-02 |
| 1643 | (REACTOME) Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.1e-01 | 6.6e-01 | 9.7e-01 | 8.5e-01 | 6.4e-01 | 3.0e-01 |
| 2086 | (REACTOME) Regulation of BACH1 activity | 3.1e-01 | 3.3e-01 | 9.2e-01 | 9.4e-01 | 3.5e-01 | 1.8e-01 |
| 663 | (REACTOME) Activation of gene expression by SREBF (SREBP) | 3.2e-01 | 6.1e-01 | 2.7e-01 | 7.8e-01 | 7.2e-01 | 8.5e-01 |
| 514 | (REACTOME) Vitamin B2 (riboflavin) metabolism | 3.2e-01 | 4.1e-01 | 9.6e-01 | 9.7e-01 | 6.9e-01 | 8.0e-01 |
| 1633 | (REACTOME) Clathrin-mediated endocytosis | 3.2e-01 | 5.5e-01 | 9.6e-01 | 9.3e-01 | 8.2e-01 | 8.4e-01 |
| 600 | (REACTOME) Basigin interactions | 3.2e-01 | 7.6e-01 | 6.0e-01 | 3.6e-01 | 9.0e-02 | 2.9e-01 |
| 1408 | (REACTOME) Formation of the cornified envelope | 3.2e-01 | 9.5e-01 | 8.5e-01 | 8.5e-01 | 9.2e-01 | 6.6e-01 |
| 105 | (REACTOME) Downregulation of ERBB4 signaling | 3.2e-01 | 8.1e-01 | 8.0e-01 | 7.9e-01 | 9.9e-01 | 8.0e-02 |
| 398 | (REACTOME) APC-Cdc20 mediated degradation of Nek2A | 3.3e-01 | 2.5e-01 | 9.2e-01 | 9.0e-01 | 7.2e-01 | 6.0e-02 |
| 1559 | (REACTOME) Ubiquitin-dependent degradation of Cyclin D | 3.3e-01 | 4.9e-01 | 8.3e-01 | 8.5e-01 | 2.6e-01 | 2.6e-01 |
| 311 | (REACTOME) Toll Like Receptor 3 (TLR3) Cascade | 3.3e-01 | 5.8e-01 | 8.5e-01 | 8.7e-01 | 2.9e-01 | 2.2e-01 |
| 1747 | (REACTOME) Fatty acid metabolism | 3.3e-01 | 5.2e-01 | 7.8e-01 | 9.1e-01 | 6.3e-01 | 8.0e-01 |
| 126 | (REACTOME) betaKlotho-mediated ligand binding | 3.3e-01 | 7.2e-01 | 9.9e-01 | 8.5e-01 | 9.4e-01 | 8.7e-01 |
| 341 | (REACTOME) TICAM1, RIP1-mediated IKK complex recruitment | 3.3e-01 | 9.4e-01 | 6.0e-01 | 8.4e-01 | 7.2e-01 | 4.6e-01 |
| 1004 | (REACTOME) TAK1-dependent IKK and NF-kappa-B activation | 3.3e-01 | 6.1e-01 | 8.5e-01 | 9.4e-01 | 8.0e-01 | 3.2e-01 |
| 1107 | (REACTOME) N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.3e-01 | 6.0e-01 | 8.7e-01 | 8.5e-01 | 3.4e-01 | 1.0e-02 |
| 1330 | (REACTOME) Cargo concentration in the ER | 3.3e-01 | 5.6e-01 | 7.8e-01 | 7.9e-01 | 2.6e-01 | 1.4e-01 |
| 1388 | (REACTOME) TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.3e-01 | 7.6e-01 | 7.3e-01 | 8.7e-01 | 7.9e-01 | 4.3e-01 |
| 1873 | (REACTOME) Degradation of GABA | 3.3e-01 | 8.4e-01 | 8.5e-01 | 9.7e-01 | 6.1e-01 | 7.1e-01 |
| 618 | (REACTOME) EGFR interacts with phospholipase C-gamma | 3.4e-01 | 7.6e-01 | 9.6e-01 | 8.5e-01 | 8.2e-01 | 5.3e-01 |
| 1877 | (REACTOME) TRAF3-dependent IRF activation pathway | 3.4e-01 | 5.0e-02 | 8.2e-01 | 8.5e-01 | 1.7e-01 | 3.0e-01 |
| 115 | (REACTOME) Ca activated K+ channels | 3.4e-01 | 9.9e-01 | 9.7e-01 | 9.8e-01 | 5.6e-01 | 1.0e+00 |
| 1851 | (REACTOME) NGF-stimulated transcription | 3.4e-01 | 4.5e-01 | 6.0e-01 | 8.5e-01 | 7.2e-01 | 3.0e-02 |
| 415 | (REACTOME) Acetylcholine binding and downstream events | 3.4e-01 | 9.2e-01 | 8.5e-01 | 9.0e-01 | 7.7e-01 | 5.3e-01 |
| 652 | (REACTOME) PI3K/AKT Signaling in Cancer | 3.4e-01 | 3.5e-01 | 8.3e-01 | 8.1e-01 | 6.9e-01 | 1.3e-01 |
| 1216 | (REACTOME) Signaling by Overexpressed Wild-Type EGFR in Cancer | 3.4e-01 | 7.1e-01 | 1.0e+00 | 8.5e-01 | 9.1e-01 | 8.0e-01 |
| 1217 | (REACTOME) Inhibition of Signaling by Overexpressed EGFR | 3.4e-01 | 7.1e-01 | 1.0e+00 | 8.5e-01 | 9.1e-01 | 8.0e-01 |
| 1266 | (REACTOME) Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 3.4e-01 | 8.6e-01 | 6.0e-01 | 8.4e-01 | 2.5e-01 | 9.6e-01 |
| 1342 | (REACTOME) Postsynaptic nicotinic acetylcholine receptors | 3.4e-01 | 9.2e-01 | 8.5e-01 | 9.0e-01 | 7.7e-01 | 5.3e-01 |
| 1876 | (REACTOME) Transferrin endocytosis and recycling | 3.4e-01 | 5.1e-01 | 7.9e-01 | 8.1e-01 | 6.0e-01 | 7.6e-01 |
| 892 | (REACTOME) EPHB-mediated forward signaling | 3.4e-01 | 9.9e-01 | 7.6e-01 | 8.5e-01 | 8.5e-01 | 3.1e-01 |
| 2097 | (REACTOME) Sensory perception of sweet, bitter, and umami (glutamate) taste | 3.4e-01 | 8.1e-01 | 8.7e-01 | 9.4e-01 | 7.1e-01 | 9.6e-01 |
| 2119 | (REACTOME) Primitive streak formation | 3.4e-01 | 1.9e-01 | 9.1e-01 | 8.5e-01 | 8.1e-01 | 8.7e-01 |
| 53 | (REACTOME) Neuronal System | 3.4e-01 | 1.0e+00 | 8.0e-01 | 9.4e-01 | 8.6e-01 | 6.8e-01 |
| 1637 | (REACTOME) Downregulation of ERBB2 signaling | 3.4e-01 | 8.7e-01 | 8.5e-01 | 9.0e-01 | 6.8e-01 | 8.0e-01 |
| 3 | (REACTOME) Hemostasis | 3.4e-01 | 6.2e-01 | 6.0e-01 | 9.5e-01 | 2.5e-01 | 4.0e-02 |
| 88 | (REACTOME) Cellular response to hypoxia | 3.4e-01 | 8.0e-02 | 7.0e-01 | 1.0e+00 | 1.7e-01 | 6.0e-02 |
| 479 | (REACTOME) p75NTR signals via NF-kB | 3.4e-01 | 4.1e-01 | 8.5e-01 | 8.5e-01 | 6.1e-01 | 4.3e-01 |
| 1334 | (REACTOME) Nucleotide Excision Repair | 3.4e-01 | 1.3e-01 | 5.4e-01 | 9.9e-01 | 6.5e-01 | 1.0e-02 |
| 1179 | (REACTOME) ABC transporter disorders | 3.4e-01 | 5.0e-02 | 8.5e-01 | 9.9e-01 | 2.2e-01 | 2.0e-02 |
| 1170 | (REACTOME) Degradation of GLI1 by the proteasome | 3.4e-01 | 1.6e-01 | 7.0e-01 | 1.0e+00 | 2.1e-01 | 3.0e-02 |
| 1295 | (REACTOME) LGI-ADAM interactions | 3.4e-01 | 9.9e-01 | 9.1e-01 | 9.6e-01 | 5.6e-01 | 8.9e-01 |
| 1892 | (REACTOME) Activated NTRK3 signals through PI3K | 3.4e-01 | 7.8e-01 | 9.8e-01 | 9.7e-01 | 4.4e-01 | 8.5e-01 |
| 155 | (REACTOME) Beta defensins | 3.4e-01 | 1.2e-01 | 6.0e-01 | 8.5e-01 | 3.4e-01 | 4.0e-01 |
| 1106 | (REACTOME) Diseases of Immune System | 3.4e-01 | 7.3e-01 | 6.0e-01 | 1.0e+00 | 6.4e-01 | 5.6e-01 |
| 1159 | (REACTOME) Diseases associated with the TLR signaling cascade | 3.4e-01 | 7.3e-01 | 6.0e-01 | 1.0e+00 | 6.4e-01 | 5.6e-01 |
| 1446 | (REACTOME) Synthesis of DNA | 3.4e-01 | 4.0e-02 | 9.6e-01 | 9.6e-01 | 2.1e-01 | 4.0e-02 |
| 1735 | (REACTOME) HDL clearance | 3.4e-01 | 8.6e-01 | 6.0e-01 | 9.2e-01 | 7.2e-01 | 7.3e-01 |
| 127 | (REACTOME) Downregulation of ERBB2:ERBB3 signaling | 3.4e-01 | 7.2e-01 | 8.3e-01 | 7.8e-01 | 9.2e-01 | 6.0e-01 |
| 1451 | (REACTOME) DNA Replication | 3.5e-01 | 3.0e-02 | 9.7e-01 | 9.2e-01 | 2.6e-01 | 4.0e-02 |
| 428 | (REACTOME) Synthesis of IP2, IP, and Ins in the cytosol | 3.5e-01 | 4.6e-01 | 2.8e-01 | 9.2e-01 | 7.8e-01 | 5.6e-01 |
| 779 | (REACTOME) Interconversion of polyamines | 3.5e-01 | 4.7e-01 | 9.7e-01 | 9.2e-01 | 7.2e-01 | 8.0e-01 |
| 853 | (REACTOME) Nuclear Receptor transcription pathway | 3.5e-01 | 6.8e-01 | 8.5e-01 | 9.2e-01 | 7.2e-01 | 6.6e-01 |
| 1344 | (REACTOME) Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | 3.5e-01 | 9.9e-01 | 8.3e-01 | 8.5e-01 | 9.2e-01 | 5.5e-01 |
| 64 | (REACTOME) Activation of BH3-only proteins | 3.5e-01 | 7.8e-01 | 9.4e-01 | 8.7e-01 | 3.7e-01 | 1.7e-01 |
| 73 | (REACTOME) Antiviral mechanism by IFN-stimulated genes | 3.5e-01 | 3.3e-01 | 9.0e-01 | 9.2e-01 | 7.4e-01 | 4.7e-01 |
| 273 | (REACTOME) Toll Like Receptor 4 (TLR4) Cascade | 3.5e-01 | 1.3e-01 | 9.0e-01 | 8.9e-01 | 3.2e-01 | 5.4e-01 |
| 414 | (REACTOME) Norepinephrine Neurotransmitter Release Cycle | 3.5e-01 | 9.2e-01 | 1.0e+00 | 8.5e-01 | 2.8e-01 | 7.9e-01 |
| 611 | (REACTOME) Xenobiotics | 3.5e-01 | 1.7e-01 | 8.3e-01 | 1.0e+00 | 7.6e-01 | 3.9e-01 |
| 1311 | (REACTOME) UCH proteinases | 3.5e-01 | 1.8e-01 | 9.2e-01 | 1.0e+00 | 2.6e-01 | 3.0e-02 |
| 481 | (REACTOME) p75NTR negatively regulates cell cycle via SC1 | 3.5e-01 | 9.4e-01 | 8.3e-01 | 8.5e-01 | 6.1e-01 | 1.0e+00 |
| 254 | (REACTOME) Cell Cycle | 3.5e-01 | 4.7e-01 | 7.1e-01 | 9.1e-01 | 5.7e-01 | 1.7e-01 |
| 827 | (REACTOME) Mitochondrial tRNA aminoacylation | 3.5e-01 | 8.6e-01 | 8.5e-01 | 9.6e-01 | 9.4e-01 | 3.4e-01 |
| 1679 | (REACTOME) ESR-mediated signaling | 3.5e-01 | 6.9e-01 | 1.0e+00 | 9.4e-01 | 7.2e-01 | 2.9e-01 |
| 1766 | (REACTOME) Signaling by Nuclear Receptors | 3.5e-01 | 8.6e-01 | 7.1e-01 | 9.4e-01 | 7.9e-01 | 7.5e-01 |
| 1393 | (REACTOME) Regulation of TP53 Degradation | 3.5e-01 | 1.6e-01 | 9.6e-01 | 9.1e-01 | 8.9e-01 | 3.6e-01 |
| 2066 | (REACTOME) Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function | 3.5e-01 | 8.8e-01 | 6.0e-01 | 3.0e-01 | 2.8e-01 | 1.0e+00 |
| 2067 | (REACTOME) Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function | 3.5e-01 | 8.8e-01 | 6.0e-01 | 3.0e-01 | 2.8e-01 | 1.0e+00 |
| 2072 | (REACTOME) Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function | 3.5e-01 | 8.8e-01 | 6.0e-01 | 3.0e-01 | 2.8e-01 | 1.0e+00 |
| 2073 | (REACTOME) Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function | 3.5e-01 | 8.8e-01 | 6.0e-01 | 3.0e-01 | 2.8e-01 | 1.0e+00 |
| 841 | (REACTOME) IRE1alpha activates chaperones | 3.6e-01 | 9.9e-01 | 6.0e-01 | 9.4e-01 | 3.4e-01 | 1.1e-01 |
| 1327 | (REACTOME) DNA Double Strand Break Response | 3.6e-01 | 8.2e-01 | 8.2e-01 | 9.4e-01 | 8.4e-01 | 1.0e-02 |
| 72 | (REACTOME) ISG15 antiviral mechanism | 3.6e-01 | 4.3e-01 | 9.0e-01 | 9.6e-01 | 7.2e-01 | 3.6e-01 |
| 1698 | (REACTOME) Regulation of PTEN mRNA translation | 3.6e-01 | 3.6e-01 | 9.4e-01 | 9.4e-01 | 6.7e-01 | 7.9e-01 |
| 1632 | (REACTOME) Cargo recognition for clathrin-mediated endocytosis | 3.6e-01 | 5.9e-01 | 8.7e-01 | 9.7e-01 | 8.4e-01 | 9.0e-01 |
| 748 | (REACTOME) WNT ligand biogenesis and trafficking | 3.6e-01 | 1.6e-01 | 6.0e-01 | 8.5e-01 | 4.4e-01 | 5.6e-01 |
| 1934 | (REACTOME) Prevention of phagosomal-lysosomal fusion | 3.6e-01 | 5.7e-01 | 9.8e-01 | 8.1e-01 | 8.9e-01 | 2.1e-01 |
| 1910 | (REACTOME) Late endosomal microautophagy | 3.7e-01 | 5.1e-01 | 9.5e-01 | 9.6e-01 | 7.4e-01 | 1.0e-01 |
| 166 | (REACTOME) Acyl chain remodelling of PS | 3.7e-01 | 7.7e-01 | 7.3e-01 | 8.5e-01 | 4.1e-01 | 2.8e-01 |
| 369 | (REACTOME) Glutathione synthesis and recycling | 3.7e-01 | 5.3e-01 | 9.3e-01 | 8.5e-01 | 8.4e-01 | 8.3e-01 |
| 1040 | (REACTOME) Interleukin-2 family signaling | 3.7e-01 | 6.1e-01 | 9.4e-01 | 9.0e-01 | 1.4e-01 | 5.7e-01 |
| 2118 | (REACTOME) Drug-mediated inhibition of CDK4/CDK6 activity | 3.7e-01 | 1.1e-01 | 8.2e-01 | 3.5e-01 | 6.1e-01 | 2.0e-02 |
| 2120 | (REACTOME) SARS-CoV-2 modulates autophagy | 3.7e-01 | 6.0e-01 | 6.0e-01 | 7.8e-01 | 8.5e-01 | 2.7e-01 |
| 1314 | (REACTOME) Ovarian tumor domain proteases | 3.7e-01 | 7.8e-01 | 8.3e-01 | 1.0e+00 | 7.0e-01 | 7.3e-01 |
| 246 | (REACTOME) AMPK inhibits chREBP transcriptional activation activity | 3.7e-01 | 9.2e-01 | 8.8e-01 | 7.8e-01 | 7.4e-01 | 4.3e-01 |
| 1349 | (REACTOME) Dual incision in TC-NER | 3.7e-01 | 1.7e-01 | 6.0e-01 | 9.4e-01 | 4.8e-01 | 3.0e-02 |
| 1908 | (REACTOME) FOXO-mediated transcription of cell death genes | 3.7e-01 | 6.3e-01 | 9.2e-01 | 9.2e-01 | 6.3e-01 | 1.7e-01 |
| 397 | (REACTOME) Chondroitin sulfate/dermatan sulfate metabolism | 3.7e-01 | 6.3e-01 | 2.3e-01 | 5.7e-01 | 3.3e-01 | 2.0e-02 |
| 1780 | (REACTOME) RHOB GTPase cycle | 3.7e-01 | 1.1e-01 | 6.1e-01 | 9.4e-01 | 8.5e-01 | 3.8e-01 |
| 1859 | (REACTOME) NTF3 activates NTRK3 signaling | 3.7e-01 | 9.4e-01 | 9.9e-01 | 9.1e-01 | 9.6e-01 | 3.7e-01 |
| 583 | (REACTOME) NRIF signals cell death from the nucleus | 3.7e-01 | 8.0e-01 | 9.9e-01 | 8.2e-01 | 8.6e-01 | 1.0e-01 |
| 878 | (REACTOME) Association of TriC/CCT with target proteins during biosynthesis | 3.7e-01 | 9.6e-01 | 9.1e-01 | 8.5e-01 | 8.3e-01 | 8.4e-01 |
| 885 | (REACTOME) Nitric oxide stimulates guanylate cyclase | 3.7e-01 | 9.2e-01 | 6.5e-01 | 8.8e-01 | 9.2e-01 | 9.5e-01 |
| 1001 | (REACTOME) Signal transduction by L1 | 3.7e-01 | 8.3e-01 | 8.5e-01 | 9.4e-01 | 8.4e-01 | 2.7e-01 |
| 1183 | (REACTOME) Disorders of transmembrane transporters | 3.7e-01 | 4.4e-01 | 6.0e-01 | 8.5e-01 | 2.2e-01 | 9.0e-02 |
| 161 | (REACTOME) Extracellular matrix organization | 3.7e-01 | 0.0e+00 | 5.4e-01 | 1.0e+00 | 1.7e-01 | 0.0e+00 |
| 765 | (REACTOME) Defective MMAA causes MMA, cblA type | 3.7e-01 | 4.4e-01 | 6.0e-01 | 8.5e-01 | 9.6e-01 | 7.1e-01 |
| 766 | (REACTOME) Defective MUT causes MMAM | 3.7e-01 | 4.4e-01 | 6.0e-01 | 8.5e-01 | 9.6e-01 | 7.1e-01 |
| 1209 | (REACTOME) TP53 Regulates Transcription of Cell Death Genes | 3.7e-01 | 6.7e-01 | 7.3e-01 | 9.0e-01 | 4.2e-01 | 2.0e-02 |
| 1322 | (REACTOME) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | 3.7e-01 | 8.1e-01 | 8.3e-01 | 9.7e-01 | 8.9e-01 | 2.0e-02 |
| 2044 | (REACTOME) SARS-CoV-1 activates/modulates innate immune responses | 3.7e-01 | 6.5e-01 | 9.2e-01 | 9.2e-01 | 4.6e-01 | 6.8e-01 |
| 2140 | (REACTOME) Diseases of mitochondrial beta oxidation | 3.7e-01 | 4.4e-01 | 6.0e-01 | 8.5e-01 | 9.6e-01 | 7.1e-01 |
| 2141 | (REACTOME) Diseases of propionyl-CoA catabolism | 3.7e-01 | 4.4e-01 | 6.0e-01 | 8.5e-01 | 9.6e-01 | 7.1e-01 |
| 1013 | (REACTOME) Cell-extracellular matrix interactions | 3.7e-01 | 9.2e-01 | 8.5e-01 | 3.7e-01 | 7.2e-01 | 7.2e-01 |
| 2089 | (REACTOME) Impaired BRCA2 binding to PALB2 | 3.7e-01 | 8.1e-01 | 5.3e-01 | 3.4e-01 | 3.5e-01 | 1.0e+00 |
| 92 | (REACTOME) Cross-presentation of particulate exogenous antigens (phagosomes) | 3.8e-01 | 2.0e-01 | 9.4e-01 | 9.0e-01 | 8.5e-01 | 2.7e-01 |
| 1157 | (REACTOME) Metabolic disorders of biological oxidation enzymes | 3.8e-01 | 9.9e-01 | 9.7e-01 | 7.9e-01 | 9.7e-01 | 9.5e-01 |
| 251 | (REACTOME) Keratan sulfate/keratin metabolism | 3.8e-01 | 3.7e-01 | 3.2e-01 | 5.5e-01 | 1.4e-01 | 3.0e-02 |
| 1155 | (REACTOME) Defective GCLC causes HAGGSD | 3.8e-01 | 9.5e-01 | 7.8e-01 | 7.8e-01 | 9.6e-01 | 7.4e-01 |
| 1722 | (REACTOME) Post-translational protein phosphorylation | 3.8e-01 | 1.5e-01 | 6.4e-01 | 9.2e-01 | 6.1e-01 | 0.0e+00 |
| 216 | (REACTOME) ZBP1(DAI) mediated induction of type I IFNs | 3.8e-01 | 8.1e-01 | 8.3e-01 | 9.4e-01 | 7.6e-01 | 6.4e-01 |
| 542 | (REACTOME) G-protein activation | 3.9e-01 | 7.8e-01 | 9.2e-01 | 9.4e-01 | 7.5e-01 | 3.5e-01 |
| 1398 | (REACTOME) Regulation of TP53 Expression and Degradation | 3.9e-01 | 1.1e-01 | 9.6e-01 | 9.1e-01 | 8.9e-01 | 4.9e-01 |
| 1557 | (REACTOME) TRAIL signaling | 3.9e-01 | 1.8e-01 | 7.9e-01 | 9.6e-01 | 6.7e-01 | 4.3e-01 |
| 108 | (REACTOME) Developmental Biology | 3.9e-01 | 5.3e-01 | 9.0e-01 | 8.6e-01 | 6.5e-01 | 7.0e-01 |
| 742 | (REACTOME) HATs acetylate histones | 3.9e-01 | 8.4e-01 | 9.3e-01 | 9.0e-01 | 6.7e-01 | 5.0e-01 |
| 531 | (REACTOME) Negative regulation of the PI3K/AKT network | 3.9e-01 | 4.9e-01 | 6.0e-01 | 9.4e-01 | 3.4e-01 | 5.1e-01 |
| 1781 | (REACTOME) RHOC GTPase cycle | 3.9e-01 | 6.0e-02 | 8.2e-01 | 9.4e-01 | 7.7e-01 | 2.9e-01 |
| 2163 | (REACTOME) Ion channel transport | 3.9e-01 | 8.1e-01 | 9.6e-01 | 8.5e-01 | 9.8e-01 | 5.6e-01 |
| 284 | (REACTOME) Signaling by NTRKs | 3.9e-01 | 6.7e-01 | 6.2e-01 | 9.5e-01 | 5.9e-01 | 3.8e-01 |
| 830 | (REACTOME) Loss of Nlp from mitotic centrosomes | 3.9e-01 | 9.3e-01 | 9.0e-01 | 9.9e-01 | 8.5e-01 | 7.9e-01 |
| 832 | (REACTOME) Loss of proteins required for interphase microtubule organization from the centrosome | 3.9e-01 | 9.3e-01 | 9.0e-01 | 9.9e-01 | 8.5e-01 | 7.9e-01 |
| 1628 | (REACTOME) AURKA Activation by TPX2 | 3.9e-01 | 9.4e-01 | 8.3e-01 | 9.7e-01 | 8.5e-01 | 7.9e-01 |
| 213 | (REACTOME) Gamma-carboxylation of protein precursors | 3.9e-01 | 9.2e-01 | 9.9e-01 | 9.1e-01 | 9.3e-01 | 2.5e-01 |
| 1259 | (REACTOME) Termination of translesion DNA synthesis | 4.0e-01 | 7.6e-01 | 6.5e-01 | 7.9e-01 | 6.1e-01 | 5.4e-01 |
| 1571 | (REACTOME) RNA Polymerase III Transcription Initiation | 4.0e-01 | 5.4e-01 | 6.0e-01 | 8.5e-01 | 3.4e-01 | 1.5e-01 |
| 601 | (REACTOME) Tie2 Signaling | 4.0e-01 | 5.0e-01 | 6.9e-01 | 9.4e-01 | 7.8e-01 | 7.6e-01 |
| 689 | (REACTOME) TRIF-mediated programmed cell death | 4.0e-01 | 5.7e-01 | 9.5e-01 | 8.5e-01 | 4.4e-01 | 3.1e-01 |
| 918 | (REACTOME) G alpha (12/13) signalling events | 4.0e-01 | 7.7e-01 | 9.1e-01 | 8.5e-01 | 3.1e-01 | 3.0e-01 |
| 97 | (REACTOME) Erythrocytes take up carbon dioxide and release oxygen | 4.0e-01 | 9.1e-01 | 8.7e-01 | 8.5e-01 | 8.9e-01 | 8.3e-01 |
| 163 | (REACTOME) O2/CO2 exchange in erythrocytes | 4.0e-01 | 9.1e-01 | 8.7e-01 | 8.5e-01 | 8.9e-01 | 8.3e-01 |
| 510 | (REACTOME) Vitamin D (calciferol) metabolism | 4.0e-01 | 9.4e-01 | 6.8e-01 | 9.4e-01 | 7.1e-01 | 6.0e-01 |
| 1558 | (REACTOME) Dissolution of Fibrin Clot | 4.0e-01 | 1.0e+00 | 8.3e-01 | 9.7e-01 | 2.1e-01 | 3.6e-01 |
| 1701 | (REACTOME) Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 4.0e-01 | 4.3e-01 | 9.5e-01 | 9.4e-01 | 6.7e-01 | 8.1e-01 |
| 1929 | (REACTOME) Transcriptional Regulation by NPAS4 | 4.0e-01 | 8.1e-01 | 7.6e-01 | 8.5e-01 | 8.1e-01 | 8.7e-01 |
| 2144 | (REACTOME) Regulation of NPAS4 mRNA translation | 4.0e-01 | 3.5e-01 | 9.5e-01 | 9.4e-01 | 6.7e-01 | 8.1e-01 |
| 48 | (REACTOME) Neurotransmitter release cycle | 4.0e-01 | 1.0e+00 | 9.6e-01 | 8.8e-01 | 7.2e-01 | 4.5e-01 |
| 112 | (REACTOME) Spry regulation of FGF signaling | 4.0e-01 | 4.7e-01 | 9.7e-01 | 9.3e-01 | 3.4e-01 | 3.7e-01 |
| 152 | (REACTOME) Regulation of signaling by NODAL | 4.0e-01 | 7.2e-01 | 9.6e-01 | 9.1e-01 | 8.2e-01 | 1.8e-01 |
| 233 | (REACTOME) Attachment of GPI anchor to uPAR | 4.0e-01 | 4.9e-01 | 1.0e+00 | 8.5e-01 | 8.4e-01 | 8.9e-01 |
| 974 | (REACTOME) Vasopressin regulates renal water homeostasis via Aquaporins | 4.0e-01 | 9.5e-01 | 9.5e-01 | 9.9e-01 | 9.2e-01 | 2.4e-01 |
| 1117 | (REACTOME) Regulation of TNFR1 signaling | 4.0e-01 | 4.9e-01 | 8.5e-01 | 9.2e-01 | 8.6e-01 | 4.4e-01 |
| 1324 | (REACTOME) Resolution of D-loop Structures through Holliday Junction Intermediates | 4.0e-01 | 7.2e-01 | 6.0e-01 | 3.0e-01 | 2.6e-01 | 1.0e+00 |
| 1389 | (REACTOME) TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | 4.0e-01 | 7.0e-01 | 9.6e-01 | 8.5e-01 | 6.8e-01 | 4.2e-01 |
| 1479 | (REACTOME) Propionyl-CoA catabolism | 4.0e-01 | 9.1e-01 | 7.3e-01 | 9.6e-01 | 2.9e-01 | 8.1e-01 |
| 1572 | (REACTOME) RNA Polymerase III Transcription Initiation From Type 1 Promoter | 4.0e-01 | 5.7e-01 | 6.0e-01 | 8.5e-01 | 3.5e-01 | 9.0e-02 |
| 1902 | (REACTOME) HCMV Late Events | 4.0e-01 | 8.8e-01 | 8.5e-01 | 9.5e-01 | 5.7e-01 | 2.0e-02 |
| 2081 | (REACTOME) FLT3 signaling by CBL mutants | 4.0e-01 | 6.4e-01 | 9.6e-01 | 7.8e-01 | 6.7e-01 | 3.0e-01 |
| 2106 | (REACTOME) SARS-CoV-1 modulates host translation machinery | 4.0e-01 | 5.0e-02 | 6.0e-01 | 8.1e-01 | 3.3e-01 | 2.7e-01 |
| 1318 | (REACTOME) Resolution of D-Loop Structures | 4.0e-01 | 7.3e-01 | 6.0e-01 | 1.7e-01 | 2.1e-01 | 1.0e+00 |
| 1808 | (REACTOME) Estrogen-dependent gene expression | 4.0e-01 | 2.4e-01 | 8.7e-01 | 8.5e-01 | 7.2e-01 | 2.6e-01 |
| 96 | (REACTOME) Cross-presentation of soluble exogenous antigens (endosomes) | 4.1e-01 | 4.0e-02 | 6.0e-01 | 9.1e-01 | 2.1e-01 | 4.0e-02 |
| 156 | (REACTOME) Defensins | 4.1e-01 | 3.0e-02 | 7.5e-01 | 8.3e-01 | 3.4e-01 | 6.5e-01 |
| 412 | (REACTOME) RIP-mediated NFkB activation via ZBP1 | 4.1e-01 | 8.3e-01 | 8.0e-01 | 9.8e-01 | 7.5e-01 | 5.2e-01 |
| 703 | (REACTOME) Stimuli-sensing channels | 4.1e-01 | 9.1e-01 | 9.1e-01 | 9.9e-01 | 9.1e-01 | 4.2e-01 |
| 767 | (REACTOME) Regulation by c-FLIP | 4.1e-01 | 3.5e-01 | 7.5e-01 | 9.1e-01 | 6.4e-01 | 3.1e-01 |
| 891 | (REACTOME) Prostacyclin signalling through prostacyclin receptor | 4.1e-01 | 5.4e-01 | 8.3e-01 | 9.9e-01 | 9.1e-01 | 4.6e-01 |
| 942 | (REACTOME) Cell-cell junction organization | 4.1e-01 | 4.0e-01 | 8.3e-01 | 9.0e-01 | 9.4e-01 | 4.0e-01 |
| 1090 | (REACTOME) CASP8 activity is inhibited | 4.1e-01 | 3.5e-01 | 7.5e-01 | 9.1e-01 | 6.4e-01 | 3.1e-01 |
| 1331 | (REACTOME) DNA Damage Recognition in GG-NER | 4.1e-01 | 2.4e-01 | 6.0e-01 | 9.0e-01 | 9.2e-01 | 1.0e-02 |
| 1452 | (REACTOME) Dimerization of procaspase-8 | 4.1e-01 | 3.5e-01 | 7.5e-01 | 9.1e-01 | 6.4e-01 | 3.1e-01 |
| 1660 | (REACTOME) MET activates STAT3 | 4.1e-01 | 7.3e-01 | 6.0e-01 | 7.9e-01 | 5.9e-01 | 4.2e-01 |
| 1678 | (REACTOME) Aryl hydrocarbon receptor signalling | 4.1e-01 | 4.6e-01 | 7.1e-01 | 8.5e-01 | 9.2e-01 | 4.5e-01 |
| 1863 | (REACTOME) RHOF GTPase cycle | 4.1e-01 | 6.4e-01 | 7.5e-01 | 8.6e-01 | 8.9e-01 | 7.5e-01 |
| 2003 | (REACTOME) Defective factor IX causes thrombophilia | 4.1e-01 | 9.1e-01 | 9.6e-01 | 9.7e-01 | 9.6e-01 | 9.1e-01 |
| 2005 | (REACTOME) Defective cofactor function of FVIIIa variant | 4.1e-01 | 9.1e-01 | 9.6e-01 | 9.7e-01 | 9.6e-01 | 9.1e-01 |
| 2006 | (REACTOME) Defective F9 variant does not activate FX | 4.1e-01 | 9.1e-01 | 9.6e-01 | 9.7e-01 | 9.6e-01 | 9.1e-01 |
| 1034 | (REACTOME) Regulation of mRNA stability by proteins that bind AU-rich elements | 4.1e-01 | 1.9e-01 | 6.5e-01 | 9.4e-01 | 1.7e-01 | 1.4e-01 |
| 272 | (REACTOME) Regulation of cholesterol biosynthesis by SREBP (SREBF) | 4.1e-01 | 6.1e-01 | 5.2e-01 | 9.6e-01 | 9.5e-01 | 4.6e-01 |
| 1347 | (REACTOME) Formation of TC-NER Pre-Incision Complex | 4.1e-01 | 1.0e-01 | 8.2e-01 | 9.8e-01 | 3.2e-01 | 2.0e-02 |
| 1315 | (REACTOME) Metalloprotease DUBs | 4.1e-01 | 8.1e-01 | 6.0e-01 | 7.9e-01 | 7.4e-01 | 5.3e-01 |
| 280 | (REACTOME) Glycosphingolipid metabolism | 4.1e-01 | 4.8e-01 | 4.9e-01 | 4.9e-01 | 4.7e-01 | 2.8e-01 |
| 1478 | (REACTOME) Histidine catabolism | 4.1e-01 | 9.1e-01 | 9.0e-01 | 9.1e-01 | 5.5e-01 | 9.6e-01 |
| 920 | (REACTOME) Sema4D induced cell migration and growth-cone collapse | 4.1e-01 | 7.9e-01 | 8.3e-01 | 8.5e-01 | 6.6e-01 | 3.7e-01 |
| 2040 | (REACTOME) Transcriptional regulation of testis differentiation | 4.1e-01 | 4.0e-01 | 9.4e-01 | 8.5e-01 | 6.9e-01 | 8.6e-01 |
| 1529 | (REACTOME) DNA Repair | 4.2e-01 | 5.0e-01 | 1.0e-02 | 9.5e-01 | 8.5e-01 | 0.0e+00 |
| 1002 | (REACTOME) Smooth Muscle Contraction | 4.2e-01 | 9.9e-01 | 7.9e-01 | 9.5e-01 | 8.4e-01 | 1.2e-01 |
| 1588 | (REACTOME) Insulin receptor recycling | 4.2e-01 | 7.5e-01 | 7.6e-01 | 8.5e-01 | 7.9e-01 | 9.1e-01 |
| 781 | (REACTOME) Apoptotic cleavage of cell adhesion proteins | 4.2e-01 | 2.4e-01 | 8.3e-01 | 8.2e-01 | 7.2e-01 | 5.5e-01 |
| 1350 | (REACTOME) Gap-filling DNA repair synthesis and ligation in TC-NER | 4.2e-01 | 1.8e-01 | 6.0e-01 | 9.4e-01 | 4.9e-01 | 5.0e-02 |
| 1415 | (REACTOME) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.2e-01 | 4.6e-01 | 6.0e-01 | 9.4e-01 | 3.8e-01 | 4.8e-01 |
| 1896 | (REACTOME) FLT3 Signaling | 4.2e-01 | 8.1e-01 | 9.6e-01 | 9.0e-01 | 8.3e-01 | 3.1e-01 |
| 533 | (REACTOME) ER to Golgi Anterograde Transport | 4.3e-01 | 6.2e-01 | 7.8e-01 | 8.5e-01 | 2.7e-01 | 5.0e-02 |
| 2121 | (REACTOME) SARS-CoV-2 modulates host translation machinery | 4.3e-01 | 5.0e-02 | 7.3e-01 | 8.9e-01 | 3.2e-01 | 1.1e-01 |
| 84 | (REACTOME) Signaling by FGFR in disease | 4.3e-01 | 8.5e-01 | 9.0e-01 | 8.5e-01 | 7.1e-01 | 3.4e-01 |
| 382 | (REACTOME) Interactions of Tat with host cellular proteins | 4.3e-01 | 9.1e-01 | 8.3e-01 | 8.5e-01 | 5.5e-01 | 6.3e-01 |
| 845 | (REACTOME) Regulation of IGF Activity by IGFBP | 4.3e-01 | 1.2e-01 | 6.3e-01 | 9.4e-01 | 6.3e-01 | 0.0e+00 |
| 1003 | (REACTOME) Aquaporin-mediated transport | 4.3e-01 | 9.5e-01 | 9.6e-01 | 9.4e-01 | 9.4e-01 | 1.3e-01 |
| 1110 | (REACTOME) Uptake and actions of bacterial toxins | 4.3e-01 | 9.9e-01 | 9.7e-01 | 9.7e-01 | 5.1e-01 | 8.1e-01 |
| 1244 | (REACTOME) Negative regulation of FGFR1 signaling | 4.3e-01 | 6.1e-01 | 9.6e-01 | 9.4e-01 | 3.8e-01 | 5.1e-01 |
| 1724 | (REACTOME) Intestinal absorption | 4.3e-01 | 9.3e-01 | 9.6e-01 | 9.4e-01 | 2.2e-01 | 3.9e-01 |
| 1751 | (REACTOME) Intestinal hexose absorption | 4.3e-01 | 9.3e-01 | 9.6e-01 | 9.4e-01 | 2.2e-01 | 3.9e-01 |
| 1552 | (REACTOME) Fatty acyl-CoA biosynthesis | 4.3e-01 | 5.1e-01 | 6.5e-01 | 9.9e-01 | 4.9e-01 | 2.8e-01 |
| 1880 | (REACTOME) TRAF6 mediated NF-kB activation | 4.3e-01 | 7.8e-01 | 8.5e-01 | 1.0e+00 | 8.5e-01 | 7.3e-01 |
| 85 | (REACTOME) Signaling by ERBB2 | 4.3e-01 | 7.3e-01 | 8.7e-01 | 9.9e-01 | 9.4e-01 | 7.8e-01 |
| 1792 | (REACTOME) RHOU GTPase cycle | 4.3e-01 | 9.9e-01 | 6.1e-01 | 8.9e-01 | 7.5e-01 | 8.9e-01 |
| 1795 | (REACTOME) RHOV GTPase cycle | 4.3e-01 | 4.8e-01 | 9.6e-01 | 7.8e-01 | 6.2e-01 | 9.6e-01 |
| 1938 | (REACTOME) Modulation by Mtb of host immune system | 4.3e-01 | 8.2e-01 | 8.2e-01 | 8.1e-01 | 8.3e-01 | 7.4e-01 |
| 432 | (REACTOME) Downstream signal transduction | 4.3e-01 | 8.7e-01 | 6.0e-01 | 9.2e-01 | 3.4e-01 | 5.7e-01 |
| 1227 | (REACTOME) Phospholipase C-mediated cascade; FGFR4 | 4.3e-01 | 8.5e-01 | 8.0e-01 | 9.0e-01 | 7.2e-01 | 8.1e-01 |
| 1596 | (REACTOME) The IPAF inflammasome | 4.4e-01 | 4.4e-01 | 9.6e-01 | 9.0e-01 | 7.6e-01 | 5.3e-01 |
| 1014 | (REACTOME) Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | 4.4e-01 | 7.7e-01 | 8.5e-01 | 9.2e-01 | 7.8e-01 | 8.0e-01 |
| 1022 | (REACTOME) Interleukin-1 processing | 4.4e-01 | 6.1e-01 | 9.7e-01 | 1.0e+00 | 3.7e-01 | 4.5e-01 |
| 838 | (REACTOME) ATF6 (ATF6-alpha) activates chaperones | 4.4e-01 | 5.0e-01 | 8.7e-01 | 3.0e-01 | 7.8e-01 | 4.9e-01 |
| 870 | (REACTOME) PD-1 signaling | 4.4e-01 | 6.7e-01 | 9.2e-01 | 7.8e-01 | 7.1e-01 | 9.7e-01 |
| 843 | (REACTOME) ATF6 (ATF6-alpha) activates chaperone genes | 4.4e-01 | 4.5e-01 | 8.5e-01 | 3.0e-01 | 8.0e-01 | 4.6e-01 |
| 1336 | (REACTOME) Dual Incision in GG-NER | 4.5e-01 | 5.4e-01 | 3.5e-01 | 8.4e-01 | 9.2e-01 | 1.0e-01 |
| 1454 | (REACTOME) G2/M DNA replication checkpoint | 4.5e-01 | 9.6e-01 | 1.0e+00 | 8.5e-01 | 2.3e-01 | 4.9e-01 |
| 1609 | (REACTOME) PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 4.5e-01 | 8.2e-01 | 8.3e-01 | 4.7e-01 | 9.4e-01 | 1.1e-01 |
| 90 | (REACTOME) Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 4.5e-01 | 9.6e-01 | 9.8e-01 | 9.7e-01 | 8.3e-01 | 1.0e-01 |
| 301 | (REACTOME) Pausing and recovery of Tat-mediated HIV elongation | 4.5e-01 | 3.3e-01 | 9.5e-01 | 8.1e-01 | 2.7e-01 | 2.0e-02 |
| 303 | (REACTOME) Tat-mediated HIV elongation arrest and recovery | 4.5e-01 | 3.3e-01 | 9.5e-01 | 8.1e-01 | 2.7e-01 | 2.0e-02 |
| 450 | (REACTOME) FGFR4 ligand binding and activation | 4.5e-01 | 8.7e-01 | 8.6e-01 | 8.5e-01 | 5.4e-01 | 7.2e-01 |
| 693 | (REACTOME) Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.5e-01 | 1.7e-01 | 6.9e-01 | 8.4e-01 | 6.4e-01 | 7.9e-01 |
| 694 | (REACTOME) Signaling by NOTCH1 in Cancer | 4.5e-01 | 1.7e-01 | 6.9e-01 | 8.4e-01 | 6.4e-01 | 7.9e-01 |
| 696 | (REACTOME) Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.5e-01 | 1.7e-01 | 6.9e-01 | 8.4e-01 | 6.4e-01 | 7.9e-01 |
| 714 | (REACTOME) Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.5e-01 | 1.7e-01 | 6.9e-01 | 8.4e-01 | 6.4e-01 | 7.9e-01 |
| 715 | (REACTOME) Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.5e-01 | 1.7e-01 | 6.9e-01 | 8.4e-01 | 6.4e-01 | 7.9e-01 |
| 795 | (REACTOME) Defective EXT2 causes exostoses 2 | 4.5e-01 | 9.5e-01 | 7.1e-01 | 9.1e-01 | 7.3e-01 | 2.2e-01 |
| 798 | (REACTOME) Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 4.5e-01 | 9.5e-01 | 7.1e-01 | 9.1e-01 | 7.3e-01 | 2.2e-01 |
| 834 | (REACTOME) Recruitment of NuMA to mitotic centrosomes | 4.5e-01 | 8.7e-01 | 7.8e-01 | 9.9e-01 | 7.5e-01 | 7.1e-01 |
| 946 | (REACTOME) Transport of bile salts and organic acids, metal ions and amine compounds | 4.5e-01 | 8.9e-01 | 6.6e-01 | 1.0e+00 | 8.4e-01 | 3.0e-02 |
| 1215 | (REACTOME) Signaling by Ligand-Responsive EGFR Variants in Cancer | 4.5e-01 | 9.6e-01 | 9.8e-01 | 9.7e-01 | 8.3e-01 | 1.0e-01 |
| 1220 | (REACTOME) Fructose metabolism | 4.5e-01 | 8.3e-01 | 6.6e-01 | 9.4e-01 | 6.9e-01 | 7.8e-01 |
| 1246 | (REACTOME) Negative regulation of FGFR3 signaling | 4.5e-01 | 5.4e-01 | 9.9e-01 | 9.4e-01 | 2.5e-01 | 4.7e-01 |
| 1513 | (REACTOME) RNA Polymerase I Promoter Opening | 4.5e-01 | 9.6e-01 | 7.8e-01 | 8.4e-01 | 6.1e-01 | 8.6e-01 |
| 1538 | (REACTOME) RNA Polymerase III Transcription | 4.5e-01 | 5.9e-01 | 6.1e-01 | 8.5e-01 | 3.4e-01 | 1.9e-01 |
| 1547 | (REACTOME) RNA Polymerase III Abortive And Retractive Initiation | 4.5e-01 | 5.9e-01 | 6.1e-01 | 8.5e-01 | 3.4e-01 | 1.9e-01 |
| 1774 | (REACTOME) Calnexin/calreticulin cycle | 4.5e-01 | 8.0e-01 | 9.1e-01 | 8.5e-01 | 3.3e-01 | 3.0e-02 |
| 1949 | (REACTOME) RAS processing | 4.5e-01 | 8.0e-01 | 9.5e-01 | 1.0e+00 | 9.2e-01 | 5.6e-01 |
| 2024 | (REACTOME) SARS-CoV Infections | 4.5e-01 | 7.3e-01 | 9.7e-01 | 9.9e-01 | 9.2e-01 | 7.9e-01 |
| 561 | (REACTOME) Cell surface interactions at the vascular wall | 4.5e-01 | 9.0e-01 | 6.0e-01 | 8.5e-01 | 3.2e-01 | 1.6e-01 |
| 644 | (REACTOME) Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.5e-01 | 7.2e-01 | 8.9e-01 | 9.5e-01 | 1.7e-01 | 4.7e-01 |
| 1594 | (REACTOME) The NLRP3 inflammasome | 4.5e-01 | 6.6e-01 | 9.6e-01 | 9.0e-01 | 6.9e-01 | 2.5e-01 |
| 867 | (REACTOME) Glyoxylate metabolism and glycine degradation | 4.5e-01 | 1.6e-01 | 9.7e-01 | 7.9e-01 | 7.2e-01 | 1.6e-01 |
| 1253 | (REACTOME) Signaling by FGFR4 in disease | 4.5e-01 | 8.2e-01 | 9.4e-01 | 9.4e-01 | 6.7e-01 | 3.1e-01 |
| 1402 | (REACTOME) Negative regulation of MET activity | 4.5e-01 | 5.6e-01 | 9.4e-01 | 7.8e-01 | 7.0e-01 | 1.3e-01 |
| 1676 | (REACTOME) RUNX1 regulates expression of components of tight junctions | 4.5e-01 | 1.7e-01 | 9.9e-01 | 8.5e-01 | 4.4e-01 | 9.1e-01 |
| 52 | (REACTOME) Transmission across Chemical Synapses | 4.5e-01 | 1.0e+00 | 8.2e-01 | 9.6e-01 | 3.5e-01 | 7.3e-01 |
| 67 | (REACTOME) GPVI-mediated activation cascade | 4.5e-01 | 6.3e-01 | 9.8e-01 | 9.4e-01 | 7.2e-01 | 1.2e-01 |
| 1489 | (REACTOME) Pyruvate metabolism and Citric Acid (TCA) cycle | 4.5e-01 | 1.6e-01 | 8.5e-01 | 8.5e-01 | 4.2e-01 | 9.0e-02 |
| 1759 | (REACTOME) Transcriptional Regulation by MECP2 | 4.5e-01 | 5.4e-01 | 9.6e-01 | 8.5e-01 | 7.2e-01 | 4.8e-01 |
| 354 | (REACTOME) Synthesis and processing of ENV and VPU | 4.5e-01 | 9.4e-01 | 9.1e-01 | 9.4e-01 | 4.2e-01 | 2.4e-01 |
| 623 | (REACTOME) Synthesis of Leukotrienes (LT) and Eoxins (EX) | 4.5e-01 | 9.4e-01 | 9.4e-01 | 9.4e-01 | 1.0e+00 | 7.2e-01 |
| 1384 | (REACTOME) TP53 Regulates Transcription of Caspase Activators and Caspases | 4.5e-01 | 4.7e-01 | 8.5e-01 | 1.0e+00 | 4.9e-01 | 6.3e-01 |
| 1280 | (REACTOME) RAF activation | 4.6e-01 | 7.9e-01 | 8.5e-01 | 7.8e-01 | 9.5e-01 | 3.7e-01 |
| 1939 | (REACTOME) Suppression of phagosomal maturation | 4.6e-01 | 5.7e-01 | 9.6e-01 | 9.2e-01 | 7.6e-01 | 1.9e-01 |
| 20 | (REACTOME) Activation of BIM and translocation to mitochondria | 4.6e-01 | 3.7e-01 | 8.0e-01 | 9.4e-01 | 9.7e-01 | 6.0e-02 |
| 1671 | (REACTOME) GABA synthesis, release, reuptake and degradation | 4.6e-01 | 7.3e-01 | 9.6e-01 | 9.4e-01 | 4.2e-01 | 8.0e-01 |
| 2162 | (REACTOME) B Cell Activation | 4.6e-01 | 6.4e-01 | 9.9e-01 | 9.9e-01 | 5.3e-01 | 2.1e-01 |
| 1879 | (REACTOME) TRAF6 mediated IRF7 activation | 4.6e-01 | 8.0e-02 | 8.3e-01 | 8.3e-01 | 2.0e-01 | 2.6e-01 |
| 1905 | (REACTOME) Chaperone Mediated Autophagy | 4.6e-01 | 3.8e-01 | 8.2e-01 | 8.5e-01 | 7.8e-01 | 5.6e-01 |
| 929 | (REACTOME) G alpha (i) signalling events | 4.6e-01 | 5.2e-01 | 8.7e-01 | 8.4e-01 | 8.4e-01 | 1.0e-02 |
| 733 | (REACTOME) SUMO is proteolytically processed | 4.7e-01 | 6.7e-01 | 7.3e-01 | 8.5e-01 | 2.9e-01 | 4.5e-01 |
| 831 | (REACTOME) Recruitment of mitotic centrosome proteins and complexes | 4.7e-01 | 9.1e-01 | 7.8e-01 | 1.0e+00 | 8.9e-01 | 6.6e-01 |
| 833 | (REACTOME) Centrosome maturation | 4.7e-01 | 9.1e-01 | 7.8e-01 | 1.0e+00 | 8.9e-01 | 6.6e-01 |
| 980 | (REACTOME) Intracellular metabolism of fatty acids regulates insulin secretion | 4.7e-01 | 1.3e-01 | 7.1e-01 | 9.5e-01 | 8.5e-01 | 8.3e-01 |
| 757 | (REACTOME) Signaling by TGF-beta Receptor Complex in Cancer | 4.7e-01 | 3.8e-01 | 6.1e-01 | 7.8e-01 | 5.7e-01 | 9.2e-01 |
| 1332 | (REACTOME) Formation of Incision Complex in GG-NER | 4.7e-01 | 7.6e-01 | 5.6e-01 | 9.4e-01 | 9.1e-01 | 1.3e-01 |
| 1472 | (REACTOME) Glucose metabolism | 4.7e-01 | 9.0e-01 | 8.8e-01 | 8.5e-01 | 9.8e-01 | 0.0e+00 |
| 1675 | (REACTOME) Digestion | 4.7e-01 | 9.1e-01 | 1.0e+00 | 9.4e-01 | NA | 8.9e-01 |
| 2091 | (REACTOME) Defective pyroptosis | 4.7e-01 | 6.9e-01 | 6.0e-01 | 8.5e-01 | 9.4e-01 | 1.1e-01 |
| 968 | (REACTOME) Deadenylation-dependent mRNA decay | 4.7e-01 | 4.4e-01 | 6.0e-01 | 9.4e-01 | 6.9e-01 | 9.2e-01 |
| 1663 | (REACTOME) Listeria monocytogenes entry into host cells | 4.7e-01 | 7.5e-01 | 9.1e-01 | 8.0e-01 | 5.4e-01 | 2.4e-01 |
| 247 | (REACTOME) Integration of energy metabolism | 4.7e-01 | 8.1e-01 | 9.0e-01 | 9.7e-01 | 7.1e-01 | 6.4e-01 |
| 701 | (REACTOME) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 4.7e-01 | 1.4e-01 | 7.2e-01 | 8.5e-01 | 7.9e-01 | 1.1e-01 |
| 702 | (REACTOME) Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 4.7e-01 | 1.4e-01 | 7.2e-01 | 8.5e-01 | 7.9e-01 | 1.1e-01 |
| 847 | (REACTOME) Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 4.7e-01 | 8.6e-01 | 9.1e-01 | 9.6e-01 | 7.9e-01 | 3.1e-01 |
| 884 | (REACTOME) Protein folding | 4.7e-01 | 3.6e-01 | 6.4e-01 | 9.4e-01 | 9.2e-01 | 9.4e-01 |
| 2150 | (REACTOME) Serine biosynthesis | 4.7e-01 | 8.1e-01 | 8.5e-01 | 9.7e-01 | 8.2e-01 | 5.6e-01 |
| 826 | (REACTOME) tRNA Aminoacylation | 4.7e-01 | 7.2e-01 | 8.3e-01 | 1.0e+00 | 1.0e+00 | 3.8e-01 |
| 925 | (REACTOME) Platelet calcium homeostasis | 4.7e-01 | 8.4e-01 | 9.5e-01 | 9.8e-01 | 9.1e-01 | 8.4e-01 |
| 1205 | (REACTOME) TP53 Regulates Metabolic Genes | 4.7e-01 | 3.8e-01 | 9.3e-01 | 9.6e-01 | 8.2e-01 | 1.2e-01 |
| 484 | (REACTOME) p75NTR regulates axonogenesis | 4.7e-01 | 9.2e-01 | 9.5e-01 | 9.2e-01 | 7.9e-01 | 5.6e-01 |
| 119 | (REACTOME) Potassium Channels | 4.7e-01 | 8.2e-01 | 6.0e-01 | 9.9e-01 | 9.2e-01 | 5.3e-01 |
| 230 | (REACTOME) Golgi Cisternae Pericentriolar Stack Reorganization | 4.7e-01 | 5.9e-01 | 9.8e-01 | 8.5e-01 | 8.7e-01 | 5.2e-01 |
| 716 | (REACTOME) NOTCH2 Activation and Transmission of Signal to the Nucleus | 4.7e-01 | 6.6e-01 | 9.7e-01 | 4.0e-01 | 5.8e-01 | 7.1e-01 |
| 839 | (REACTOME) XBP1(S) activates chaperone genes | 4.7e-01 | 9.9e-01 | 6.0e-01 | 9.4e-01 | 3.7e-01 | 1.5e-01 |
| 965 | (REACTOME) Organic anion transporters | 4.7e-01 | 8.0e-01 | 9.6e-01 | 6.1e-01 | 7.9e-01 | 3.3e-01 |
| 191 | (REACTOME) Amino Acid conjugation | 4.8e-01 | 8.9e-01 | 8.3e-01 | 3.1e-01 | 7.5e-01 | 6.0e-01 |
| 212 | (REACTOME) Conjugation of carboxylic acids | 4.8e-01 | 8.9e-01 | 8.3e-01 | 3.1e-01 | 7.5e-01 | 6.0e-01 |
| 536 | (REACTOME) Carnitine metabolism | 4.8e-01 | 4.1e-01 | 7.3e-01 | 9.4e-01 | 8.4e-01 | 9.0e-02 |
| 551 | (REACTOME) Signaling by FGFR2 amplification mutants | 4.8e-01 | 9.1e-01 | 6.4e-01 | 6.1e-01 | 1.9e-01 | 7.5e-01 |
| 615 | (REACTOME) PRC2 methylates histones and DNA | 4.8e-01 | 8.6e-01 | 8.7e-01 | 9.4e-01 | 6.5e-01 | 4.6e-01 |
| 969 | (REACTOME) Deadenylation of mRNA | 4.8e-01 | 6.6e-01 | 6.0e-01 | 9.4e-01 | 6.4e-01 | 9.2e-01 |
| 979 | (REACTOME) Defective NEU1 causes sialidosis | 4.8e-01 | 6.0e-01 | 9.2e-01 | 9.9e-01 | 7.5e-01 | 8.1e-01 |
| 988 | (REACTOME) VEGFA-VEGFR2 Pathway | 4.8e-01 | 6.8e-01 | 9.1e-01 | 1.0e+00 | 9.2e-01 | 5.3e-01 |
| 1028 | (REACTOME) JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | 4.8e-01 | 7.3e-01 | 8.7e-01 | 9.4e-01 | 5.9e-01 | 5.0e-01 |
| 1029 | (REACTOME) Activation of the AP-1 family of transcription factors | 4.8e-01 | 1.7e-01 | 9.1e-01 | 9.2e-01 | 8.3e-01 | 1.9e-01 |
| 1203 | (REACTOME) RHO GTPases Activate ROCKs | 4.8e-01 | 8.4e-01 | 8.3e-01 | 8.6e-01 | 3.8e-01 | 2.5e-01 |
| 1321 | (REACTOME) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | 4.8e-01 | 7.6e-01 | 6.0e-01 | 3.0e-01 | 3.4e-01 | 1.0e+00 |
| 1553 | (REACTOME) Activation of BID and translocation to mitochondria | 4.8e-01 | 8.2e-01 | 9.9e-01 | 9.4e-01 | 8.9e-01 | 7.9e-01 |
| 1556 | (REACTOME) FasL/ CD95L signaling | 4.8e-01 | 7.7e-01 | 8.5e-01 | 8.5e-01 | 4.7e-01 | 5.6e-01 |
| 1597 | (REACTOME) Interferon gamma signaling | 4.8e-01 | 1.8e-01 | 5.2e-01 | 3.4e-01 | 4.8e-01 | 7.0e-02 |
| 1603 | (REACTOME) Synthesis of PIPs in the nucleus | 4.8e-01 | 9.1e-01 | 6.3e-01 | 8.5e-01 | 3.9e-01 | 8.9e-01 |
| 1743 | (REACTOME) G beta:gamma signalling through BTK | 4.8e-01 | 7.2e-01 | 8.5e-01 | 9.8e-01 | 8.9e-01 | 4.1e-01 |
| 1773 | (REACTOME) ER Quality Control Compartment (ERQC) | 4.8e-01 | 8.3e-01 | 9.0e-01 | 8.8e-01 | 3.4e-01 | 2.0e-02 |
| 1797 | (REACTOME) NOTCH3 Activation and Transmission of Signal to the Nucleus | 4.8e-01 | 7.7e-01 | 9.6e-01 | 8.5e-01 | 7.7e-01 | 6.6e-01 |
| 581 | (REACTOME) NFG and proNGF binds to p75NTR | 4.8e-01 | 4.8e-01 | 9.6e-01 | 8.5e-01 | 5.9e-01 | 8.7e-01 |
| 133 | (REACTOME) BMAL1:CLOCK,NPAS2 activates circadian gene expression | 4.8e-01 | 8.0e-01 | 8.3e-01 | 9.1e-01 | 2.1e-01 | 7.9e-01 |
| 570 | (REACTOME) eNOS activation | 4.8e-01 | 9.4e-01 | 9.3e-01 | 9.4e-01 | 7.2e-01 | 5.3e-01 |
| 857 | (REACTOME) GPCR downstream signalling | 4.8e-01 | 1.2e-01 | 8.3e-01 | 5.1e-01 | 2.6e-01 | 0.0e+00 |
| 1210 | (REACTOME) Defective ALG14 causes ALG14-CMS | 4.8e-01 | 8.1e-01 | 8.5e-01 | 8.5e-01 | 8.6e-01 | 9.0e-01 |
| 1245 | (REACTOME) Negative regulation of FGFR2 signaling | 4.8e-01 | 6.2e-01 | 9.8e-01 | 9.4e-01 | 5.8e-01 | 5.1e-01 |
| 586 | (REACTOME) Axonal growth stimulation | 4.8e-01 | 4.7e-01 | 8.5e-01 | 9.4e-01 | 6.5e-01 | 4.8e-01 |
| 534 | (REACTOME) Membrane Trafficking | 4.8e-01 | 9.5e-01 | 9.7e-01 | 8.9e-01 | 7.9e-01 | 5.0e-02 |
| 516 | (REACTOME) Metabolism of vitamins and cofactors | 4.8e-01 | 7.4e-01 | 8.7e-01 | 9.2e-01 | 7.5e-01 | 6.0e-01 |
| 649 | (REACTOME) Visual phototransduction | 4.8e-01 | 6.4e-01 | 7.1e-01 | 8.9e-01 | 9.5e-01 | 3.5e-01 |
| 729 | (REACTOME) Scavenging by Class F Receptors | 4.8e-01 | 9.9e-01 | 6.3e-01 | 8.5e-01 | 7.6e-01 | 7.3e-01 |
| 812 | (REACTOME) Peptide ligand-binding receptors | 4.8e-01 | 2.0e-01 | 9.7e-01 | 8.7e-01 | 7.6e-01 | 0.0e+00 |
| 1144 | (REACTOME) Organic cation/anion/zwitterion transport | 4.8e-01 | 7.0e-01 | 8.5e-01 | 9.4e-01 | 6.9e-01 | 3.5e-01 |
| 1222 | (REACTOME) Vesicle-mediated transport | 4.8e-01 | 9.9e-01 | 9.6e-01 | 9.1e-01 | 7.8e-01 | 1.3e-01 |
| 1223 | (REACTOME) Lactose synthesis | 4.8e-01 | 9.0e-01 | 9.0e-01 | 9.4e-01 | 6.5e-01 | 1.3e-01 |
| 1473 | (REACTOME) Fructose catabolism | 4.8e-01 | 8.6e-01 | 9.1e-01 | 9.7e-01 | 4.0e-01 | 4.2e-01 |
| 1844 | (REACTOME) Erythropoietin activates RAS | 4.8e-01 | 6.3e-01 | 8.3e-01 | 9.8e-01 | 5.4e-01 | 6.3e-01 |
| 1861 | (REACTOME) Activated NTRK3 signals through PLCG1 | 4.8e-01 | 9.4e-01 | 8.9e-01 | 9.1e-01 | 4.4e-01 | 2.4e-01 |
| 305 | (REACTOME) HIV elongation arrest and recovery | 4.9e-01 | 4.2e-01 | 9.6e-01 | 8.1e-01 | 3.4e-01 | 4.0e-02 |
| 306 | (REACTOME) Pausing and recovery of HIV elongation | 4.9e-01 | 4.2e-01 | 9.6e-01 | 8.1e-01 | 3.4e-01 | 4.0e-02 |
| 951 | (REACTOME) Metal ion SLC transporters | 4.9e-01 | 5.9e-01 | 7.6e-01 | 9.7e-01 | 9.2e-01 | 1.3e-01 |
| 478 | (REACTOME) Axonal growth inhibition (RHOA activation) | 4.9e-01 | 9.2e-01 | 9.7e-01 | 9.4e-01 | 9.2e-01 | 5.8e-01 |
| 54 | (REACTOME) Formation of RNA Pol II elongation complex | 4.9e-01 | 6.1e-01 | 9.8e-01 | 8.5e-01 | 2.7e-01 | 1.1e-01 |
| 1566 | (REACTOME) RNA Polymerase II Transcription Elongation | 4.9e-01 | 6.1e-01 | 9.8e-01 | 8.5e-01 | 2.7e-01 | 1.1e-01 |
| 1656 | (REACTOME) InlB-mediated entry of Listeria monocytogenes into host cell | 4.9e-01 | 5.0e-01 | 9.3e-01 | 8.4e-01 | 3.4e-01 | 9.0e-02 |
| 288 | (REACTOME) Terminal pathway of complement | 4.9e-01 | 9.9e-01 | 9.0e-01 | 8.5e-01 | 8.0e-01 | 9.3e-01 |
| 1900 | (REACTOME) HCMV Early Events | 5.0e-01 | 4.3e-01 | 9.2e-01 | 1.0e+00 | 9.8e-01 | 6.0e-01 |
| 1811 | (REACTOME) Biosynthesis of specialized proresolving mediators (SPMs) | 5.0e-01 | 9.5e-01 | 7.3e-01 | 8.5e-01 | 7.1e-01 | 8.3e-01 |
| 928 | (REACTOME) ADP signalling through P2Y purinoceptor 1 | 5.0e-01 | 9.2e-01 | 9.4e-01 | 9.0e-01 | 6.1e-01 | 7.7e-01 |
| 308 | (REACTOME) Trafficking and processing of endosomal TLR | 5.0e-01 | 8.8e-01 | 8.2e-01 | 9.8e-01 | 6.5e-01 | 2.5e-01 |
| 886 | (REACTOME) ADP signalling through P2Y purinoceptor 12 | 5.0e-01 | 8.2e-01 | 8.5e-01 | 1.0e+00 | 8.9e-01 | 2.2e-01 |
| 768 | (REACTOME) Regulation of HSF1-mediated heat shock response | 5.0e-01 | 9.1e-01 | 8.6e-01 | 9.6e-01 | 7.3e-01 | 5.6e-01 |
| 681 | (REACTOME) Interaction With Cumulus Cells And The Zona Pellucida | 5.0e-01 | 3.3e-01 | 7.6e-01 | 8.3e-01 | 7.2e-01 | 2.5e-01 |
| 1015 | (REACTOME) Interleukin-1 family signaling | 5.0e-01 | 1.5e-01 | 6.0e-01 | 9.8e-01 | 3.2e-01 | 2.9e-01 |
| 543 | (REACTOME) Metabolism of nitric oxide: NOS3 activation and regulation | 5.1e-01 | 6.2e-01 | 9.6e-01 | 5.5e-01 | 6.0e-01 | 8.1e-01 |
| 298 | (REACTOME) HIV Transcription Elongation | 5.1e-01 | 3.3e-01 | 9.7e-01 | 8.5e-01 | 3.0e-01 | 1.4e-01 |
| 300 | (REACTOME) Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.1e-01 | 3.3e-01 | 9.7e-01 | 8.5e-01 | 3.0e-01 | 1.4e-01 |
| 304 | (REACTOME) Tat-mediated elongation of the HIV-1 transcript | 5.1e-01 | 3.3e-01 | 9.7e-01 | 8.5e-01 | 3.0e-01 | 1.4e-01 |
| 877 | (REACTOME) Chaperonin-mediated protein folding | 5.1e-01 | 4.7e-01 | 6.3e-01 | 9.4e-01 | 9.4e-01 | 8.5e-01 |
| 1510 | (REACTOME) Translation | 5.1e-01 | 0.0e+00 | 6.2e-01 | 8.5e-01 | 0.0e+00 | 0.0e+00 |
| 1965 | (REACTOME) Purinergic signaling in leishmaniasis infection | 5.1e-01 | 6.8e-01 | 9.7e-01 | 9.4e-01 | 5.9e-01 | 4.6e-01 |
| 1978 | (REACTOME) Cell recruitment (pro-inflammatory response) | 5.1e-01 | 6.8e-01 | 9.7e-01 | 9.4e-01 | 5.9e-01 | 4.6e-01 |
| 1976 | (REACTOME) Killing mechanisms | 5.1e-01 | 1.2e-01 | 9.2e-01 | 9.6e-01 | 4.9e-01 | 8.6e-01 |
| 2009 | (REACTOME) WNT5:FZD7-mediated leishmania damping | 5.1e-01 | 1.2e-01 | 9.2e-01 | 9.6e-01 | 4.9e-01 | 8.6e-01 |
| 137 | (REACTOME) Activation of PUMA and translocation to mitochondria | 5.1e-01 | 3.4e-01 | 8.8e-01 | 8.5e-01 | 4.1e-01 | 1.0e-02 |
| 560 | (REACTOME) ERKs are inactivated | 5.1e-01 | 9.1e-01 | 9.1e-01 | 9.0e-01 | 9.3e-01 | 8.0e-01 |
| 753 | (REACTOME) Defects in vitamin and cofactor metabolism | 5.1e-01 | 8.6e-01 | 6.0e-01 | 9.4e-01 | 8.5e-01 | 4.4e-01 |
| 1075 | (REACTOME) Defective LFNG causes SCDO3 | 5.1e-01 | 6.0e-02 | 1.0e+00 | 1.0e+00 | 8.0e-01 | 7.3e-01 |
| 1600 | (REACTOME) Transport of organic anions | 5.1e-01 | 7.5e-01 | 9.9e-01 | 1.0e+00 | 8.3e-01 | 3.8e-01 |
| 1998 | (REACTOME) Signaling by KIT in disease | 5.1e-01 | 9.5e-01 | 9.2e-01 | 9.1e-01 | 3.4e-01 | 5.6e-01 |
| 2000 | (REACTOME) Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | 5.1e-01 | 9.5e-01 | 9.2e-01 | 9.1e-01 | 3.4e-01 | 5.6e-01 |
| 182 | (REACTOME) Phospholipid metabolism | 5.1e-01 | 3.5e-01 | 9.2e-01 | 3.6e-01 | 4.1e-01 | 6.3e-01 |
| 392 | (REACTOME) Conjugation of benzoate with glycine | 5.1e-01 | 9.7e-01 | 8.5e-01 | 4.2e-01 | 9.7e-01 | NA |
| 986 | (REACTOME) Binding of TCF/LEF:CTNNB1 to target gene promoters | 5.1e-01 | 3.5e-01 | 8.6e-01 | 8.4e-01 | 8.7e-01 | 8.4e-01 |
| 1072 | (REACTOME) Defective LARGE causes MDDGA6 and MDDGB6 | 5.1e-01 | 5.7e-01 | 6.0e-01 | 1.0e+00 | 7.4e-01 | 9.4e-01 |
| 368 | (REACTOME) Transport and synthesis of PAPS | 5.1e-01 | 1.7e-01 | 5.8e-01 | 5.5e-01 | 5.1e-01 | 3.2e-01 |
| 967 | (REACTOME) Thromboxane signalling through TP receptor | 5.1e-01 | 8.4e-01 | 8.2e-01 | 9.8e-01 | 8.9e-01 | 5.8e-01 |
| 322 | (REACTOME) Influenza Viral RNA Transcription and Replication | 5.1e-01 | 0.0e+00 | 8.9e-01 | 1.0e+00 | 2.6e-01 | 0.0e+00 |
| 744 | (REACTOME) Processing and activation of SUMO | 5.1e-01 | 5.6e-01 | 7.0e-01 | 7.8e-01 | 3.7e-01 | 3.3e-01 |
| 874 | (REACTOME) Post-chaperonin tubulin folding pathway | 5.1e-01 | 3.3e-01 | 6.0e-01 | 8.0e-01 | 7.2e-01 | 9.1e-01 |
| 1012 | (REACTOME) Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 5.1e-01 | 9.4e-01 | 9.1e-01 | 1.0e+00 | 5.6e-01 | 7.0e-01 |
| 1070 | (REACTOME) GPCR ligand binding | 5.1e-01 | 5.0e-02 | 6.2e-01 | 9.8e-01 | 3.5e-01 | 0.0e+00 |
| 1335 | (REACTOME) Global Genome Nucleotide Excision Repair (GG-NER) | 5.1e-01 | 2.1e-01 | 6.0e-01 | 9.5e-01 | 8.2e-01 | 5.0e-02 |
| 1346 | (REACTOME) RNA Polymerase II Pre-transcription Events | 5.1e-01 | 5.3e-01 | 9.9e-01 | 8.5e-01 | 2.7e-01 | 1.4e-01 |
| 1605 | (REACTOME) Signaling by PTK6 | 5.1e-01 | 4.0e-02 | 6.0e-01 | 9.4e-01 | 9.8e-01 | 5.7e-01 |
| 1620 | (REACTOME) Protein ubiquitination | 5.1e-01 | 6.4e-01 | 8.7e-01 | 8.5e-01 | 4.0e-01 | 2.6e-01 |
| 1726 | (REACTOME) Phenylalanine and tyrosine metabolism | 5.1e-01 | 6.7e-01 | 9.7e-01 | 8.0e-01 | 8.7e-01 | 7.9e-01 |
| 1765 | (REACTOME) Signaling by Non-Receptor Tyrosine Kinases | 5.1e-01 | 4.0e-02 | 6.0e-01 | 9.4e-01 | 9.8e-01 | 5.7e-01 |
| 1768 | (REACTOME) Signaling by TGFB family members | 5.1e-01 | 3.6e-01 | 8.7e-01 | 8.5e-01 | 1.7e-01 | 8.6e-01 |
| 1867 | (REACTOME) Meiotic recombination | 5.1e-01 | 6.9e-01 | 3.5e-01 | 1.0e+00 | 5.9e-01 | 9.9e-01 |
| 2052 | (REACTOME) Attachment and Entry_2 | 5.1e-01 | 3.7e-01 | 6.2e-01 | 9.6e-01 | 7.8e-01 | 3.1e-01 |
| 921 | (REACTOME) Other semaphorin interactions | 5.2e-01 | 2.0e-01 | 7.9e-01 | 7.8e-01 | 4.7e-01 | 5.7e-01 |
| 7 | (REACTOME) MAPK3 (ERK1) activation | 5.2e-01 | 7.5e-01 | 6.9e-01 | 9.5e-01 | 6.9e-01 | 9.8e-01 |
| 1146 | (REACTOME) Phase 4 - resting membrane potential | 5.2e-01 | 9.7e-01 | 9.0e-01 | 9.8e-01 | 7.9e-01 | 7.7e-01 |
| 1646 | (REACTOME) TFAP2 (AP-2) family regulates transcription of other transcription factors | 5.2e-01 | 7.6e-01 | 6.5e-01 | 8.5e-01 | 8.7e-01 | 2.5e-01 |
| 1891 | (REACTOME) Transport to the Golgi and subsequent modification | 5.2e-01 | 7.6e-01 | 8.3e-01 | 8.5e-01 | 2.9e-01 | 1.1e-01 |
| 1109 | (REACTOME) Uptake and function of diphtheria toxin | 5.2e-01 | 6.6e-01 | 8.5e-01 | 8.5e-01 | 7.1e-01 | 4.0e-01 |
| 228 | (REACTOME) Early Phase of HIV Life Cycle | 5.2e-01 | 5.6e-01 | 8.5e-01 | 9.8e-01 | 7.2e-01 | 3.7e-01 |
| 1772 | (REACTOME) Extra-nuclear estrogen signaling | 5.2e-01 | 1.9e-01 | 1.0e+00 | 9.9e-01 | 8.3e-01 | 3.0e-01 |
| 871 | (REACTOME) Prefoldin mediated transfer of substrate to CCT/TriC | 5.2e-01 | 1.9e-01 | 6.0e-01 | 9.5e-01 | 5.1e-01 | 7.3e-01 |
| 220 | (REACTOME) Cysteine formation from homocysteine | 5.2e-01 | 4.4e-01 | 9.1e-01 | 7.9e-01 | 3.4e-01 | 8.1e-01 |
| 911 | (REACTOME) Sema4D in semaphorin signaling | 5.2e-01 | 8.2e-01 | 8.3e-01 | 8.5e-01 | 5.5e-01 | 8.0e-01 |
| 1972 | (REACTOME) Selective autophagy | 5.2e-01 | 3.6e-01 | 8.3e-01 | 9.0e-01 | 5.1e-01 | 3.0e-02 |
| 1468 | (REACTOME) Glycolysis | 5.2e-01 | 8.9e-01 | 8.9e-01 | 9.5e-01 | 1.0e+00 | 0.0e+00 |
| 1916 | (REACTOME) Activation of RAC1 downstream of NMDARs | 5.2e-01 | 7.9e-01 | 8.5e-01 | 8.7e-01 | 9.8e-01 | 8.0e-01 |
| 1108 | (REACTOME) DNA methylation | 5.3e-01 | 3.4e-01 | 9.8e-01 | 9.4e-01 | 6.7e-01 | 2.5e-01 |
| 2122 | (REACTOME) Atorvastatin ADME | 5.3e-01 | 1.1e-01 | 7.3e-01 | 8.5e-01 | 6.8e-01 | 5.6e-01 |
| 21 | (REACTOME) Activation of BAD and translocation to mitochondria | 5.3e-01 | 8.8e-01 | 8.9e-01 | 9.4e-01 | 8.6e-01 | 4.3e-01 |
| 1299 | (REACTOME) Surfactant metabolism | 5.3e-01 | 4.0e-02 | 6.0e-01 | 9.5e-01 | 7.8e-01 | 2.6e-01 |
| 1560 | (REACTOME) Synthesis of very long-chain fatty acyl-CoAs | 5.3e-01 | 5.9e-01 | 9.7e-01 | 9.6e-01 | 4.2e-01 | 1.1e-01 |
| 525 | (REACTOME) Signalling to STAT3 | 5.3e-01 | 6.8e-01 | 6.0e-01 | 8.5e-01 | 6.9e-01 | 7.4e-01 |
| 1200 | (REACTOME) RHO GTPases activate IQGAPs | 5.3e-01 | 9.1e-01 | 8.7e-01 | 9.8e-01 | 9.1e-01 | 5.4e-01 |
| 391 | (REACTOME) Conjugation of salicylate with glycine | 5.3e-01 | 8.3e-01 | 8.7e-01 | 3.5e-01 | 7.5e-01 | 6.0e-01 |
| 474 | (REACTOME) vRNP Assembly | 5.3e-01 | 8.1e-01 | 6.0e-01 | 9.4e-01 | 7.0e-01 | 6.6e-01 |
| 904 | (REACTOME) Acetylcholine regulates insulin secretion | 5.3e-01 | 5.7e-01 | 9.8e-01 | 8.2e-01 | 6.7e-01 | 3.1e-01 |
| 771 | (REACTOME) Cellular response to heat stress | 5.3e-01 | 9.0e-01 | 8.7e-01 | 1.0e+00 | 7.2e-01 | 4.7e-01 |
| 855 | (REACTOME) GSD 0 | 5.3e-01 | 9.7e-01 | 9.1e-01 | 9.6e-01 | 6.4e-01 | 8.7e-01 |
| 872 | (REACTOME) Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 5.3e-01 | 2.8e-01 | 6.1e-01 | 9.4e-01 | 5.9e-01 | 6.8e-01 |
| 1118 | (REACTOME) TNFR1-induced NFkappaB signaling pathway | 5.3e-01 | 7.7e-01 | 7.8e-01 | 9.4e-01 | 8.1e-01 | 6.1e-01 |
| 1273 | (REACTOME) RHO GTPases Activate WASPs and WAVEs | 5.3e-01 | 8.7e-01 | 8.3e-01 | 8.2e-01 | 9.2e-01 | 2.5e-01 |
| 805 | (REACTOME) Class A/1 (Rhodopsin-like receptors) | 5.3e-01 | 3.0e-01 | 8.5e-01 | 8.8e-01 | 6.1e-01 | 0.0e+00 |
| 1721 | (REACTOME) Nucleotide salvage | 5.3e-01 | 9.3e-01 | 6.4e-01 | 8.5e-01 | 6.3e-01 | 8.1e-01 |
| 243 | (REACTOME) Glucagon signaling in metabolic regulation | 5.4e-01 | 9.0e-01 | 9.3e-01 | 9.5e-01 | 9.0e-01 | 2.5e-01 |
| 562 | (REACTOME) Signaling by Hippo | 5.4e-01 | 4.7e-01 | 8.9e-01 | 8.9e-01 | 6.7e-01 | 2.7e-01 |
| 1959 | (REACTOME) Defective factor XII causes hereditary angioedema | 5.4e-01 | 8.5e-01 | 8.5e-01 | 7.8e-01 | NA | 8.2e-01 |
| 1154 | (REACTOME) Ion homeostasis | 5.4e-01 | 8.4e-01 | 9.6e-01 | 7.8e-01 | 4.5e-01 | 3.7e-01 |
| 1414 | (REACTOME) PI5P Regulates TP53 Acetylation | 5.4e-01 | 9.8e-01 | 9.1e-01 | 9.8e-01 | 4.1e-01 | 9.1e-01 |
| 502 | (REACTOME) Pregnenolone biosynthesis | 5.4e-01 | 9.1e-01 | 9.6e-01 | 9.4e-01 | 8.5e-01 | 7.0e-01 |
| 75 | (REACTOME) Signaling by NODAL | 5.4e-01 | 9.2e-01 | 9.9e-01 | 8.6e-01 | 8.6e-01 | 1.4e-01 |
| 1396 | (REACTOME) Regulation of TP53 Activity through Methylation | 5.4e-01 | 8.4e-01 | 7.9e-01 | 3.4e-01 | 9.6e-01 | 1.0e-01 |
| 756 | (REACTOME) Loss of Function of SMAD2/3 in Cancer | 5.5e-01 | 3.1e-01 | 6.2e-01 | 7.8e-01 | 5.5e-01 | 9.1e-01 |
| 758 | (REACTOME) SMAD2/3 Phosphorylation Motif Mutants in Cancer | 5.5e-01 | 3.1e-01 | 6.2e-01 | 7.8e-01 | 5.5e-01 | 9.1e-01 |
| 234 | (REACTOME) HIV Infection | 5.5e-01 | 2.1e-01 | 8.9e-01 | 9.2e-01 | 1.4e-01 | 5.0e-02 |
| 953 | (REACTOME) Sodium/Proton exchangers | 5.5e-01 | 9.9e-01 | 6.1e-01 | 9.1e-01 | 6.7e-01 | 8.3e-01 |
| 68 | (REACTOME) Platelet degranulation | 5.5e-01 | 8.2e-01 | 7.8e-01 | 8.5e-01 | 6.9e-01 | 4.8e-01 |
| 759 | (REACTOME) Glycogen synthesis | 5.5e-01 | 8.3e-01 | 8.3e-01 | 9.4e-01 | 8.9e-01 | 5.0e-02 |
| 2109 | (REACTOME) Azathioprine ADME | 5.5e-01 | 3.6e-01 | 8.1e-01 | 1.0e+00 | 7.2e-01 | 9.4e-01 |
| 429 | (REACTOME) Synthesis of IPs in the nucleus | 5.5e-01 | 6.6e-01 | 6.2e-01 | 8.5e-01 | 6.6e-01 | 2.5e-01 |
| 821 | (REACTOME) Myoclonic epilepsy of Lafora | 5.5e-01 | 6.9e-01 | 7.8e-01 | 9.4e-01 | 7.6e-01 | 5.0e-02 |
| 952 | (REACTOME) Sodium/Calcium exchangers | 5.5e-01 | 9.7e-01 | 1.0e+00 | 7.8e-01 | 9.4e-01 | 9.6e-01 |
| 1054 | (REACTOME) Repression of WNT target genes | 5.5e-01 | 7.1e-01 | 6.0e-01 | 8.5e-01 | 6.2e-01 | 7.6e-01 |
| 1511 | (REACTOME) Pyrimidine salvage | 5.5e-01 | 8.5e-01 | 8.5e-01 | 8.4e-01 | 8.3e-01 | 8.9e-01 |
| 2023 | (REACTOME) Translation of Replicase and Assembly of the Replication Transcription Complex_1 | 5.5e-01 | 8.0e-01 | 9.5e-01 | 8.5e-01 | 9.1e-01 | 2.7e-01 |
| 2055 | (REACTOME) Translation of Replicase and Assembly of the Replication Transcription Complex_2 | 5.5e-01 | 8.0e-01 | 9.5e-01 | 8.5e-01 | 9.1e-01 | 2.7e-01 |
| 1383 | (REACTOME) TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | 5.5e-01 | 2.6e-01 | 6.0e-01 | 9.0e-01 | 3.5e-01 | 0.0e+00 |
| 944 | (REACTOME) Regulation of insulin secretion | 5.5e-01 | 8.1e-01 | 9.2e-01 | 9.8e-01 | 9.2e-01 | 4.1e-01 |
| 1260 | (REACTOME) HHAT G278V doesn’t palmitoylate Hh-Np | 5.5e-01 | 9.2e-01 | 9.0e-01 | 9.0e-01 | 9.8e-01 | 5.4e-01 |
| 544 | (REACTOME) Assembly of collagen fibrils and other multimeric structures | 5.5e-01 | 3.0e-02 | 6.0e-01 | 9.4e-01 | 4.8e-01 | 1.0e-02 |
| 1399 | (REACTOME) Metabolism of fat-soluble vitamins | 5.5e-01 | 6.3e-01 | 6.2e-01 | 8.5e-01 | 7.2e-01 | 9.0e-02 |
| 2128 | (REACTOME) Retinoid metabolism and transport | 5.5e-01 | 6.3e-01 | 6.2e-01 | 8.5e-01 | 7.2e-01 | 9.0e-02 |
| 1737 | (REACTOME) LDL clearance | 5.5e-01 | 9.0e-01 | 9.2e-01 | 9.0e-01 | 9.6e-01 | 4.3e-01 |
| 293 | (REACTOME) Formation of HIV elongation complex in the absence of HIV Tat | 5.6e-01 | 4.3e-01 | 9.9e-01 | 8.5e-01 | 2.6e-01 | 1.3e-01 |
| 1674 | (REACTOME) Receptor Mediated Mitophagy | 5.6e-01 | 6.0e-01 | 7.9e-01 | 7.8e-01 | 6.4e-01 | 1.3e-01 |
| 1279 | (REACTOME) TNFs bind their physiological receptors | 5.6e-01 | 8.4e-01 | 8.2e-01 | 3.2e-01 | 6.7e-01 | 3.4e-01 |
| 410 | (REACTOME) Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization | 5.6e-01 | 4.1e-01 | 8.5e-01 | 9.0e-01 | 6.4e-01 | 6.7e-01 |
| 1914 | (REACTOME) Regulation of FOXO transcriptional activity by acetylation | 5.6e-01 | 3.4e-01 | 8.3e-01 | 8.3e-01 | 3.7e-01 | 2.0e-02 |
| 1208 | (REACTOME) Regulation of TP53 Activity | 5.6e-01 | 3.1e-01 | 8.3e-01 | 8.8e-01 | 6.9e-01 | 0.0e+00 |
| 800 | (REACTOME) Loss of Function of TGFBR1 in Cancer | 5.6e-01 | 5.8e-01 | 7.1e-01 | 7.8e-01 | 8.4e-01 | 3.8e-01 |
| 801 | (REACTOME) TGFBR1 LBD Mutants in Cancer | 5.6e-01 | 5.8e-01 | 7.1e-01 | 7.8e-01 | 8.4e-01 | 3.8e-01 |
| 1174 | (REACTOME) Activation of anterior HOX genes in hindbrain development during early embryogenesis | 5.7e-01 | 9.6e-01 | 8.3e-01 | 8.2e-01 | 8.5e-01 | 9.3e-01 |
| 1184 | (REACTOME) Activation of HOX genes during differentiation | 5.7e-01 | 9.6e-01 | 8.3e-01 | 8.2e-01 | 8.5e-01 | 9.3e-01 |
| 1196 | (REACTOME) RHO GTPases activate PKNs | 5.7e-01 | 6.7e-01 | 8.5e-01 | 9.5e-01 | 3.3e-01 | 2.8e-01 |
| 670 | (REACTOME) MASTL Facilitates Mitotic Progression | 5.7e-01 | 6.9e-01 | 6.2e-01 | 8.2e-01 | 9.0e-01 | 9.7e-01 |
| 940 | (REACTOME) Class C/3 (Metabotropic glutamate/pheromone receptors) | 5.7e-01 | 8.0e-01 | 9.9e-01 | 1.0e+00 | 7.2e-01 | 6.3e-01 |
| 966 | (REACTOME) Role of ABL in ROBO-SLIT signaling | 5.7e-01 | 9.2e-01 | 9.7e-01 | 9.4e-01 | 8.9e-01 | 1.0e+00 |
| 1312 | (REACTOME) Josephin domain DUBs | 5.7e-01 | 9.0e-01 | 9.4e-01 | 8.8e-01 | 8.1e-01 | 2.5e-01 |
| 1884 | (REACTOME) Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | 5.7e-01 | 6.4e-01 | 9.6e-01 | 7.8e-01 | 3.9e-01 | 6.9e-01 |
| 195 | (REACTOME) Fibronectin matrix formation | 5.7e-01 | 6.0e-01 | 6.0e-01 | 9.7e-01 | 8.8e-01 | 4.3e-01 |
| 1276 | (REACTOME) TNFR2 non-canonical NF-kB pathway | 5.7e-01 | 1.5e-01 | 6.3e-01 | 8.2e-01 | 4.9e-01 | 2.7e-01 |
| 539 | (REACTOME) TCF dependent signaling in response to WNT | 5.7e-01 | 8.2e-01 | 7.9e-01 | 1.0e+00 | 5.2e-01 | 3.2e-01 |
| 2001 | (REACTOME) Signaling by PDGFR in disease | 5.7e-01 | 9.5e-01 | 8.7e-01 | 8.5e-01 | 5.5e-01 | 5.4e-01 |
| 2010 | (REACTOME) Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 5.7e-01 | 9.5e-01 | 8.7e-01 | 8.5e-01 | 5.5e-01 | 5.4e-01 |
| 2011 | (REACTOME) Signaling by PDGFRA extracellular domain mutants | 5.7e-01 | 9.5e-01 | 8.7e-01 | 8.5e-01 | 5.5e-01 | 5.4e-01 |
| 2060 | (REACTOME) RND3 GTPase cycle | 5.7e-01 | 4.4e-01 | 8.3e-01 | 9.0e-01 | 7.9e-01 | 2.1e-01 |
| 2161 | (REACTOME) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | 5.7e-01 | 6.8e-01 | 9.1e-01 | 9.4e-01 | 7.3e-01 | 4.3e-01 |
| 1385 | (REACTOME) TP53 Regulates Transcription of Death Receptors and Ligands | 5.7e-01 | 4.7e-01 | 8.9e-01 | 9.4e-01 | 3.5e-01 | 1.0e-02 |
| 1742 | (REACTOME) Phenylalanine metabolism | 5.7e-01 | 7.6e-01 | 9.6e-01 | 8.5e-01 | 9.2e-01 | 5.7e-01 |
| 837 | (REACTOME) ATF4 activates genes in response to endoplasmic reticulum stress | 5.7e-01 | 9.1e-01 | 8.5e-01 | 9.1e-01 | 6.6e-01 | 7.5e-01 |
| 1518 | (REACTOME) RNA Polymerase III Chain Elongation | 5.7e-01 | 3.9e-01 | 6.0e-01 | 8.5e-01 | 3.2e-01 | 5.0e-02 |
| 571 | (REACTOME) NOSTRIN mediated eNOS trafficking | 5.7e-01 | 4.6e-01 | 8.6e-01 | 7.8e-01 | 6.4e-01 | 6.8e-01 |
| 83 | (REACTOME) ROS and RNS production in phagocytes | 5.7e-01 | 9.4e-01 | 6.0e-01 | 8.5e-01 | 8.4e-01 | 7.1e-01 |
| 1025 | (REACTOME) MAPK targets/ Nuclear events mediated by MAP kinases | 5.7e-01 | 5.4e-01 | 9.4e-01 | 9.0e-01 | 9.7e-01 | 5.0e-01 |
| 1826 | (REACTOME) Regulation of MECP2 expression and activity | 5.8e-01 | 8.2e-01 | 8.8e-01 | 9.6e-01 | 8.4e-01 | 5.3e-01 |
| 106 | (REACTOME) PI3K/AKT Signaling | 5.8e-01 | 4.6e-01 | 6.0e-01 | 9.4e-01 | 6.9e-01 | 1.4e-01 |
| 433 | (REACTOME) Signaling by PDGF | 5.8e-01 | 4.1e-01 | 6.0e-01 | 9.5e-01 | 7.8e-01 | 2.8e-01 |
| 506 | (REACTOME) Cobalamin (Cbl, vitamin B12) transport and metabolism | 5.8e-01 | 3.3e-01 | 8.5e-01 | 9.8e-01 | 8.1e-01 | 4.9e-01 |
| 584 | (REACTOME) p75NTR recruits signalling complexes | 5.8e-01 | 7.5e-01 | 8.7e-01 | 8.2e-01 | 7.2e-01 | 4.4e-01 |
| 745 | (REACTOME) Glycogen storage diseases | 5.8e-01 | 5.7e-01 | 7.9e-01 | 9.2e-01 | 8.5e-01 | 1.0e-01 |
| 786 | (REACTOME) Diseases associated with glycosaminoglycan metabolism | 5.8e-01 | 9.7e-01 | 6.0e-01 | 9.2e-01 | 5.5e-01 | 2.0e-02 |
| 1270 | (REACTOME) Diseases of carbohydrate metabolism | 5.8e-01 | 5.7e-01 | 7.9e-01 | 9.2e-01 | 8.5e-01 | 1.0e-01 |
| 1313 | (REACTOME) Ub-specific processing proteases | 5.8e-01 | 3.8e-01 | 6.0e-01 | 9.9e-01 | 1.4e-01 | 2.9e-01 |
| 1648 | (REACTOME) TFAP2 (AP-2) family regulates transcription of growth factors and their receptors | 5.8e-01 | 9.7e-01 | 9.6e-01 | 9.4e-01 | 7.9e-01 | 8.0e-01 |
| 738 | (REACTOME) Regulation of innate immune responses to cytosolic DNA | 5.8e-01 | 8.4e-01 | 8.3e-01 | 7.8e-01 | 7.2e-01 | 3.5e-01 |
| 179 | (REACTOME) Synthesis of PIPs at the ER membrane | 5.8e-01 | 9.2e-01 | 9.9e-01 | 9.4e-01 | 6.1e-01 | 5.6e-01 |
| 1644 | (REACTOME) E3 ubiquitin ligases ubiquitinate target proteins | 5.8e-01 | 5.4e-01 | 8.6e-01 | 9.9e-01 | 4.8e-01 | 3.3e-01 |
| 1687 | (REACTOME) Regulation of RUNX2 expression and activity | 5.8e-01 | 2.3e-01 | 8.6e-01 | 9.0e-01 | 2.4e-01 | 1.9e-01 |
| 1810 | (REACTOME) Biosynthesis of DHA-derived SPMs | 5.8e-01 | 7.2e-01 | 6.4e-01 | 7.8e-01 | 7.1e-01 | 7.9e-01 |
| 2035 | (REACTOME) Translation of Structural Proteins_1 | 5.8e-01 | 7.9e-01 | 6.0e-01 | 7.8e-01 | 7.6e-01 | 7.9e-01 |
| 914 | (REACTOME) Ca2+ pathway | 5.8e-01 | 4.4e-01 | 9.4e-01 | 9.1e-01 | 1.8e-01 | 3.8e-01 |
| 650 | (REACTOME) NOTCH2 intracellular domain regulates transcription | 5.8e-01 | 6.1e-01 | 8.5e-01 | 9.1e-01 | 9.3e-01 | 1.4e-01 |
| 687 | (REACTOME) Oncogene Induced Senescence | 5.8e-01 | 9.3e-01 | 8.5e-01 | 9.1e-01 | 8.4e-01 | 7.8e-01 |
| 1032 | (REACTOME) Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 5.8e-01 | 8.0e-01 | 7.5e-01 | 9.2e-01 | 4.0e-01 | 6.6e-01 |
| 1197 | (REACTOME) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | 5.8e-01 | 9.9e-01 | 7.2e-01 | 9.2e-01 | 7.9e-01 | 3.7e-01 |
| 1993 | (REACTOME) Signaling by ERBB2 TMD/JMD mutants | 5.8e-01 | 5.1e-01 | 6.0e-01 | 9.1e-01 | 9.6e-01 | 8.0e-01 |
| 485 | (REACTOME) p75 NTR receptor-mediated signalling | 5.9e-01 | 8.1e-01 | 9.4e-01 | 7.8e-01 | 6.5e-01 | 6.8e-01 |
| 722 | (REACTOME) Nuclear Envelope (NE) Reassembly | 5.9e-01 | 8.2e-01 | 6.3e-01 | 9.2e-01 | 8.3e-01 | 4.3e-01 |
| 1250 | (REACTOME) Signaling by FGFR3 | 5.9e-01 | 7.2e-01 | 9.9e-01 | 9.0e-01 | 3.5e-01 | 2.6e-01 |
| 1885 | (REACTOME) IRAK1 recruits IKK complex | 5.9e-01 | 9.7e-01 | 8.5e-01 | 1.0e+00 | 7.8e-01 | 6.9e-01 |
| 2113 | (REACTOME) IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 5.9e-01 | 9.7e-01 | 8.5e-01 | 1.0e+00 | 7.8e-01 | 6.9e-01 |
| 427 | (REACTOME) Synthesis of pyrophosphates in the cytosol | 5.9e-01 | 6.0e-01 | 8.5e-01 | 9.4e-01 | 9.9e-01 | 6.3e-01 |
| 1764 | (REACTOME) Intracellular signaling by second messengers | 5.9e-01 | 4.9e-01 | 6.2e-01 | 9.4e-01 | 7.5e-01 | 2.5e-01 |
| 1555 | (REACTOME) Apoptotic execution phase | 6.0e-01 | 5.1e-01 | 6.2e-01 | 9.4e-01 | 9.9e-01 | 4.9e-01 |
| 637 | (REACTOME) Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 6.0e-01 | 1.7e-01 | 9.6e-01 | 9.9e-01 | 3.6e-01 | 3.0e-01 |
| 1730 | (REACTOME) Assembly of active LPL and LIPC lipase complexes | 6.0e-01 | 8.4e-01 | 8.6e-01 | 9.2e-01 | 3.2e-01 | 7.9e-01 |
| 229 | (REACTOME) Late Phase of HIV Life Cycle | 6.0e-01 | 6.4e-01 | 9.6e-01 | 9.2e-01 | 2.8e-01 | 3.0e-02 |
| 480 | (REACTOME) NRAGE signals death through JNK | 6.0e-01 | 2.2e-01 | 8.6e-01 | 8.4e-01 | 5.6e-01 | 6.8e-01 |
| 1096 | (REACTOME) Negative epigenetic regulation of rRNA expression | 6.0e-01 | 6.1e-01 | 6.0e-01 | 9.4e-01 | 2.7e-01 | 2.7e-01 |
| 1135 | (REACTOME) Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 6.0e-01 | 8.3e-01 | 9.9e-01 | 9.7e-01 | 9.8e-01 | 4.1e-01 |
| 1642 | (REACTOME) VLDLR internalisation and degradation | 6.0e-01 | 5.3e-01 | 8.6e-01 | 3.4e-01 | 9.8e-01 | 6.8e-01 |
| 1801 | (REACTOME) NOTCH4 Activation and Transmission of Signal to the Nucleus | 6.0e-01 | 8.3e-01 | 1.0e+00 | 8.5e-01 | 6.3e-01 | 5.3e-01 |
| 475 | (REACTOME) Androgen biosynthesis | 6.0e-01 | 4.6e-01 | 6.0e-01 | 8.1e-01 | 8.4e-01 | 3.1e-01 |
| 873 | (REACTOME) Formation of tubulin folding intermediates by CCT/TriC | 6.0e-01 | 4.6e-01 | 6.0e-01 | 9.1e-01 | 6.4e-01 | 9.2e-01 |
| 1129 | (REACTOME) Signaling by Retinoic Acid | 6.0e-01 | 5.6e-01 | 9.7e-01 | 9.2e-01 | 7.9e-01 | 4.6e-01 |
| 350 | (REACTOME) Signaling by TGF-beta Receptor Complex | 6.1e-01 | 4.4e-01 | 8.3e-01 | 9.4e-01 | 9.0e-02 | 9.5e-01 |
| 383 | (REACTOME) Activation of ATR in response to replication stress | 6.1e-01 | 4.0e-01 | 8.5e-01 | 8.1e-01 | 7.9e-01 | 9.8e-01 |
| 1599 | (REACTOME) Advanced glycosylation endproduct receptor signaling | 6.1e-01 | 8.2e-01 | 6.3e-01 | 8.7e-01 | 5.6e-01 | 6.1e-01 |
| 1027 | (REACTOME) activated TAK1 mediates p38 MAPK activation | 6.1e-01 | 8.0e-01 | 8.3e-01 | 9.8e-01 | 8.3e-01 | 1.8e-01 |
| 274 | (REACTOME) Synthesis of PIPs at the plasma membrane | 6.1e-01 | 4.4e-01 | 6.0e-01 | 8.5e-01 | 5.8e-01 | 7.6e-01 |
| 57 | (REACTOME) MAPK1 (ERK2) activation | 6.1e-01 | 7.8e-01 | 6.5e-01 | 9.4e-01 | 6.9e-01 | 6.3e-01 |
| 608 | (REACTOME) Cytochrome P450 - arranged by substrate type | 6.1e-01 | 3.3e-01 | 9.6e-01 | 9.4e-01 | 7.1e-01 | 8.9e-01 |
| 620 | (REACTOME) MHC class II antigen presentation | 6.1e-01 | 6.3e-01 | 9.6e-01 | 9.0e-01 | 7.9e-01 | 5.8e-01 |
| 982 | (REACTOME) Zinc transporters | 6.1e-01 | 9.1e-01 | 8.3e-01 | 9.4e-01 | 8.7e-01 | 2.6e-01 |
| 1254 | (REACTOME) Signaling by FGFR1 in disease | 6.1e-01 | 8.1e-01 | 8.8e-01 | 7.8e-01 | 8.3e-01 | 3.1e-01 |
| 1601 | (REACTOME) Interconversion of 2-oxoglutarate and 2-hydroxyglutarate | 6.1e-01 | 6.3e-01 | 6.0e-01 | 9.8e-01 | 7.2e-01 | 3.7e-01 |
| 2008 | (REACTOME) Defective gamma-carboxylation of F9 | 6.1e-01 | 8.2e-01 | 8.7e-01 | 9.7e-01 | 9.8e-01 | 2.5e-01 |
| 875 | (REACTOME) Beta-oxidation of very long chain fatty acids | 6.1e-01 | 3.8e-01 | 6.8e-01 | 9.6e-01 | 9.4e-01 | 5.0e-01 |
| 2160 | (REACTOME) Factors involved in megakaryocyte development and platelet production | 6.1e-01 | 1.7e-01 | 9.1e-01 | 9.9e-01 | 7.4e-01 | 8.4e-01 |
| 626 | (REACTOME) Arachidonic acid metabolism | 6.1e-01 | 6.7e-01 | 8.3e-01 | 9.1e-01 | 8.3e-01 | 4.2e-01 |
| 2061 | (REACTOME) RND2 GTPase cycle | 6.1e-01 | 8.0e-01 | 7.3e-01 | 8.5e-01 | 6.6e-01 | 4.3e-01 |
| 2148 | (REACTOME) Early SARS-CoV-2 Infection Events | 6.1e-01 | 6.4e-01 | 7.3e-01 | 9.1e-01 | 8.5e-01 | 7.9e-01 |
| 135 | (REACTOME) Elevation of cytosolic Ca2+ levels | 6.1e-01 | 6.1e-01 | 8.0e-01 | 8.4e-01 | 8.5e-01 | 7.3e-01 |
| 2130 | (REACTOME) Regulation of NF-kappa B signaling | 6.2e-01 | 9.6e-01 | 6.0e-01 | 8.5e-01 | 8.5e-01 | 4.7e-01 |
| 421 | (REACTOME) Signaling by cytosolic FGFR1 fusion mutants | 6.2e-01 | 9.3e-01 | 8.3e-01 | 8.5e-01 | 7.4e-01 | 5.1e-01 |
| 491 | (REACTOME) Signaling by VEGF | 6.2e-01 | 7.7e-01 | 8.9e-01 | 1.0e+00 | 6.9e-01 | 2.5e-01 |
| 772 | (REACTOME) Attenuation phase | 6.2e-01 | 9.2e-01 | 6.0e-01 | 8.8e-01 | 8.4e-01 | 7.9e-01 |
| 760 | (REACTOME) Defects in biotin (Btn) metabolism | 6.2e-01 | 6.3e-01 | 8.5e-01 | 1.0e+00 | 7.9e-01 | 4.0e-01 |
| 774 | (REACTOME) Defective HLCS causes multiple carboxylase deficiency | 6.2e-01 | 6.3e-01 | 8.5e-01 | 1.0e+00 | 7.9e-01 | 4.0e-01 |
| 1359 | (REACTOME) ERBB2 Regulates Cell Motility | 6.2e-01 | 3.4e-01 | 6.0e-01 | 9.2e-01 | 8.5e-01 | 4.8e-01 |
| 1507 | (REACTOME) Recycling of eIF2:GDP | 6.2e-01 | 8.8e-01 | 7.6e-01 | 8.5e-01 | 3.4e-01 | 5.1e-01 |
| 1635 | (REACTOME) Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models | 6.2e-01 | 8.8e-01 | 7.2e-01 | 9.7e-01 | 5.9e-01 | 9.0e-01 |
| 1636 | (REACTOME) Neurodegenerative Diseases | 6.2e-01 | 8.8e-01 | 7.2e-01 | 9.7e-01 | 5.9e-01 | 9.0e-01 |
| 2104 | (REACTOME) Defective Intrinsic Pathway for Apoptosis | 6.2e-01 | 8.8e-01 | 7.2e-01 | 9.7e-01 | 5.9e-01 | 9.0e-01 |
| 1960 | (REACTOME) Leishmania infection | 6.2e-01 | 1.8e-01 | 8.8e-01 | 1.0e+00 | 3.4e-01 | 6.0e-02 |
| 457 | (REACTOME) FGFR2b ligand binding and activation | 6.2e-01 | 7.9e-01 | 9.6e-01 | 8.8e-01 | 6.9e-01 | 7.1e-01 |
| 648 | (REACTOME) The retinoid cycle in cones (daylight vision) | 6.2e-01 | 5.6e-01 | 6.0e-01 | 8.4e-01 | 7.6e-01 | 7.9e-01 |
| 1928 | (REACTOME) Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 6.2e-01 | 4.0e-02 | 8.6e-01 | 9.1e-01 | 7.2e-01 | 6.0e-01 |
| 1935 | (REACTOME) Blockage of phagosome acidification | 6.2e-01 | 9.0e-01 | 9.8e-01 | 8.5e-01 | 4.8e-01 | 6.8e-01 |
| 1604 | (REACTOME) ERBB2 Activates PTK6 Signaling | 6.2e-01 | 2.4e-01 | 6.0e-01 | 9.4e-01 | 9.2e-01 | 6.9e-01 |
| 49 | (REACTOME) Neurotransmitter clearance | 6.2e-01 | 1.0e+00 | 7.2e-01 | 9.6e-01 | 8.8e-01 | 7.1e-01 |
| 540 | (REACTOME) WNT mediated activation of DVL | 6.2e-01 | 8.8e-01 | 6.0e-01 | 9.5e-01 | 7.2e-01 | 3.8e-01 |
| 2022 | (REACTOME) Potential therapeutics for SARS | 6.2e-01 | 9.3e-01 | 9.6e-01 | 8.9e-01 | 9.4e-01 | 9.8e-01 |
| 2053 | (REACTOME) Maturation of nucleoprotein_2 | 6.2e-01 | 4.4e-01 | 7.1e-01 | 5.0e-01 | 6.3e-01 | 5.9e-01 |
| 196 | (REACTOME) Polo-like kinase mediated events | 6.2e-01 | 9.7e-01 | 6.0e-01 | 8.7e-01 | 5.0e-01 | 4.2e-01 |
| 235 | (REACTOME) Host Interactions of HIV factors | 6.2e-01 | 1.5e-01 | 7.9e-01 | 1.0e+00 | 2.5e-01 | 1.7e-01 |
| 515 | (REACTOME) Metabolism of water-soluble vitamins and cofactors | 6.2e-01 | 8.5e-01 | 6.0e-01 | 9.0e-01 | 5.5e-01 | 8.1e-01 |
| 1997 | (REACTOME) Sealing of the nuclear envelope (NE) by ESCRT-III | 6.2e-01 | 6.8e-01 | 6.0e-01 | 8.5e-01 | 9.2e-01 | 7.6e-01 |
| 1574 | (REACTOME) RNA Polymerase III Transcription Initiation From Type 3 Promoter | 6.3e-01 | 4.4e-01 | 6.0e-01 | 8.5e-01 | 2.5e-01 | 2.4e-01 |
| 172 | (REACTOME) Synthesis of PG | 6.3e-01 | 7.6e-01 | 9.6e-01 | 9.4e-01 | 6.3e-01 | 7.2e-01 |
| 682 | (REACTOME) Mitotic Metaphase and Anaphase | 6.3e-01 | 2.6e-01 | 6.0e-01 | 1.0e+00 | 3.1e-01 | 9.0e-02 |
| 1242 | (REACTOME) SHC-mediated cascade:FGFR4 | 6.3e-01 | 8.0e-01 | 9.7e-01 | 9.9e-01 | 5.1e-01 | 5.1e-01 |
| 1727 | (REACTOME) Aspartate and asparagine metabolism | 6.3e-01 | 1.0e-02 | 7.3e-01 | 3.7e-01 | 2.9e-01 | 1.4e-01 |
| 2132 | (REACTOME) Uptake of dietary cobalamins into enterocytes | 6.3e-01 | 8.8e-01 | 9.1e-01 | 9.1e-01 | 9.4e-01 | 1.0e+00 |
| 627 | (REACTOME) Synthesis of 15-eicosatetraenoic acid derivatives | 6.3e-01 | 9.0e-01 | 9.0e-01 | 9.9e-01 | 8.9e-01 | 6.1e-01 |
| 692 | (REACTOME) Signaling by Leptin | 6.3e-01 | 9.1e-01 | 7.8e-01 | 9.0e-01 | 5.0e-01 | 6.0e-01 |
| 804 | (REACTOME) Signaling by GPCR | 6.3e-01 | 1.0e-02 | 6.0e-01 | 7.8e-01 | 1.7e-01 | 0.0e+00 |
| 947 | (REACTOME) Bicarbonate transporters | 6.3e-01 | 7.5e-01 | 9.0e-01 | 9.1e-01 | 8.6e-01 | 6.8e-01 |
| 1059 | (REACTOME) SUMOylation of immune response proteins | 6.3e-01 | 6.4e-01 | 1.0e+00 | 9.1e-01 | 2.5e-01 | 8.9e-01 |
| 1345 | (REACTOME) Highly calcium permeable nicotinic acetylcholine receptors | 6.3e-01 | 9.9e-01 | 9.2e-01 | 8.6e-01 | 9.2e-01 | 5.5e-01 |
| 1778 | (REACTOME) Signaling by NOTCH3 | 6.3e-01 | 4.0e-01 | 8.5e-01 | 3.7e-01 | 6.1e-01 | 5.3e-01 |
| 299 | (REACTOME) Transcription of the HIV genome | 6.3e-01 | 4.7e-01 | 1.0e+00 | 8.5e-01 | 2.0e-01 | 2.8e-01 |
| 1424 | (REACTOME) Mitotic Anaphase | 6.3e-01 | 2.6e-01 | 6.0e-01 | 1.0e+00 | 3.1e-01 | 9.0e-02 |
| 614 | (REACTOME) Activated NOTCH1 Transmits Signal to the Nucleus | 6.3e-01 | 2.4e-01 | 9.5e-01 | 3.5e-01 | 5.4e-01 | 7.5e-01 |
| 998 | (REACTOME) Formyl peptide receptors bind formyl peptides and many other ligands | 6.3e-01 | 6.3e-01 | 6.5e-01 | 9.7e-01 | 4.3e-01 | 2.7e-01 |
| 44 | (REACTOME) ALKBH3 mediated reversal of alkylation damage | 6.3e-01 | 8.9e-01 | 6.5e-01 | 8.8e-01 | 4.5e-01 | 6.9e-01 |
| 598 | (REACTOME) Regulation of gene expression in early pancreatic precursor cells | 6.3e-01 | 6.9e-01 | 9.9e-01 | 8.5e-01 | 6.2e-01 | 7.9e-01 |
| 1535 | (REACTOME) DNA Damage Reversal | 6.3e-01 | 8.9e-01 | 6.5e-01 | 8.8e-01 | 4.5e-01 | 6.9e-01 |
| 1536 | (REACTOME) Reversal of alkylation damage by DNA dioxygenases | 6.3e-01 | 8.9e-01 | 6.5e-01 | 8.8e-01 | 4.5e-01 | 6.9e-01 |
| 818 | (REACTOME) Negative regulation of TCF-dependent signaling by WNT ligand antagonists | 6.3e-01 | 5.1e-01 | 8.3e-01 | 3.4e-01 | 3.8e-01 | 9.7e-01 |
| 915 | (REACTOME) PCP/CE pathway | 6.3e-01 | 4.1e-01 | 8.7e-01 | 9.9e-01 | 4.7e-01 | 2.9e-01 |
| 960 | (REACTOME) NoRC negatively regulates rRNA expression | 6.3e-01 | 6.4e-01 | 6.0e-01 | 9.4e-01 | 3.1e-01 | 2.7e-01 |
| 1308 | (REACTOME) Deubiquitination | 6.3e-01 | 6.1e-01 | 6.0e-01 | 1.0e+00 | 2.0e-01 | 3.2e-01 |
| 1807 | (REACTOME) Noncanonical activation of NOTCH3 | 6.3e-01 | 9.5e-01 | 6.0e-01 | 9.4e-01 | 3.7e-01 | 5.1e-01 |
| 643 | (REACTOME) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 6.3e-01 | 8.9e-01 | 6.9e-01 | 7.8e-01 | 7.6e-01 | 4.2e-01 |
| 964 | (REACTOME) Inactivation of CDC42 and RAC1 | 6.3e-01 | 4.2e-01 | 9.7e-01 | 8.5e-01 | 5.6e-01 | 4.9e-01 |
| 1167 | (REACTOME) CLEC7A (Dectin-1) induces NFAT activation | 6.3e-01 | 8.8e-01 | 9.7e-01 | 9.1e-01 | 6.1e-01 | 8.0e-01 |
| 1193 | (REACTOME) CD209 (DC-SIGN) signaling | 6.3e-01 | 9.7e-01 | 6.2e-01 | 8.5e-01 | 5.2e-01 | 5.8e-01 |
| 1374 | (REACTOME) Signaling by moderate kinase activity BRAF mutants | 6.3e-01 | 8.1e-01 | 9.7e-01 | 9.0e-01 | 9.4e-01 | 7.5e-01 |
| 1376 | (REACTOME) Signaling by RAS mutants | 6.3e-01 | 8.1e-01 | 9.7e-01 | 9.0e-01 | 9.4e-01 | 7.5e-01 |
| 1379 | (REACTOME) Paradoxical activation of RAF signaling by kinase inactive BRAF | 6.3e-01 | 8.1e-01 | 9.7e-01 | 9.0e-01 | 9.4e-01 | 7.5e-01 |
| 1782 | (REACTOME) CDC42 GTPase cycle | 6.3e-01 | 3.0e-02 | 6.2e-01 | 8.8e-01 | 4.1e-01 | 4.0e-02 |
| 1953 | (REACTOME) Signaling downstream of RAS mutants | 6.3e-01 | 8.1e-01 | 9.7e-01 | 9.0e-01 | 9.4e-01 | 7.5e-01 |
| 1131 | (REACTOME) Release of Hh-Np from the secreting cell | 6.4e-01 | 3.3e-01 | 9.1e-01 | 6.3e-01 | 6.8e-01 | 2.2e-01 |
| 1618 | (REACTOME) MET activates RAS signaling | 6.4e-01 | 8.1e-01 | 7.1e-01 | 9.4e-01 | 2.6e-01 | 3.2e-01 |
| 500 | (REACTOME) Formation of annular gap junctions | 6.4e-01 | 8.2e-01 | 9.6e-01 | 1.0e+00 | 6.3e-01 | 8.4e-01 |
| 565 | (REACTOME) Regulation of actin dynamics for phagocytic cup formation | 6.4e-01 | 9.2e-01 | 9.2e-01 | 9.1e-01 | 9.2e-01 | 2.4e-01 |
| 678 | (REACTOME) Condensation of Prometaphase Chromosomes | 6.4e-01 | 9.8e-01 | 9.6e-01 | 9.1e-01 | 9.9e-01 | 9.7e-01 |
| 1940 | (REACTOME) Response of Mtb to phagocytosis | 6.4e-01 | 6.1e-01 | 7.6e-01 | 9.1e-01 | 9.1e-01 | 4.7e-01 |
| 1298 | (REACTOME) Defective ABCD4 causes MAHCJ | 6.4e-01 | 9.5e-01 | 7.2e-01 | 9.1e-01 | 7.2e-01 | 8.5e-01 |
| 671 | (REACTOME) Separation of Sister Chromatids | 6.4e-01 | 1.7e-01 | 8.3e-01 | 1.0e+00 | 2.5e-01 | 8.0e-02 |
| 1995 | (REACTOME) Acetylcholine inhibits contraction of outer hair cells | 6.4e-01 | 8.1e-01 | 6.0e-01 | 9.8e-01 | 8.0e-01 | 9.9e-01 |
| 2031 | (REACTOME) Maturation of nucleoprotein_1 | 6.4e-01 | 2.9e-01 | 6.1e-01 | 4.8e-01 | 6.4e-01 | 6.1e-01 |
| 186 | (REACTOME) Signaling by Activin | 6.4e-01 | 8.5e-01 | 6.3e-01 | 8.5e-01 | 3.8e-01 | 5.8e-01 |
| 887 | (REACTOME) G beta:gamma signalling through PI3Kgamma | 6.4e-01 | 7.2e-01 | 8.5e-01 | 9.6e-01 | 6.4e-01 | 4.5e-01 |
| 1153 | (REACTOME) Physiological factors | 6.4e-01 | 6.8e-01 | 6.0e-01 | 8.3e-01 | 8.9e-01 | 5.1e-01 |
| 103 | (REACTOME) PLCG1 events in ERBB2 signaling | 6.4e-01 | 1.0e+00 | 8.8e-01 | 9.3e-01 | 8.4e-01 | 9.4e-01 |
| 1164 | (REACTOME) IRAK4 deficiency (TLR5) | 6.4e-01 | 8.1e-01 | 7.9e-01 | 9.4e-01 | 6.9e-01 | 5.0e-01 |
| 1897 | (REACTOME) Protein localization | 6.4e-01 | 6.0e-02 | 9.4e-01 | 8.5e-01 | 6.1e-01 | 4.0e-02 |
| 452 | (REACTOME) FGFR3b ligand binding and activation | 6.5e-01 | 8.1e-01 | 9.6e-01 | 9.8e-01 | 6.5e-01 | 4.4e-01 |
| 572 | (REACTOME) NOSIP mediated eNOS trafficking | 6.5e-01 | 9.0e-01 | 9.9e-01 | 9.4e-01 | 8.9e-01 | 8.0e-01 |
| 1160 | (REACTOME) MyD88 deficiency (TLR2/4) | 6.5e-01 | 1.7e-01 | 9.4e-01 | 9.5e-01 | 7.7e-01 | 3.0e-01 |
| 1165 | (REACTOME) IRAK4 deficiency (TLR2/4) | 6.5e-01 | 1.7e-01 | 9.4e-01 | 9.5e-01 | 7.7e-01 | 3.0e-01 |
| 1248 | (REACTOME) Signaling by FGFR1 | 6.5e-01 | 6.5e-01 | 9.7e-01 | 9.2e-01 | 5.8e-01 | 5.6e-01 |
| 1729 | (REACTOME) Chylomicron assembly | 6.5e-01 | 5.6e-01 | 8.5e-01 | 9.0e-01 | 6.9e-01 | 7.0e-02 |
| 1848 | (REACTOME) LXRs regulate gene expression linked to cholesterol transport and efflux | 6.5e-01 | 5.9e-01 | 5.7e-01 | 9.1e-01 | 4.9e-01 | 4.4e-01 |
| 2054 | (REACTOME) Translation of Structural Proteins_2 | 6.5e-01 | 8.4e-01 | 6.1e-01 | 7.8e-01 | 9.2e-01 | 7.6e-01 |
| 344 | (REACTOME) Prolonged ERK activation events | 6.5e-01 | 9.9e-01 | 9.5e-01 | 9.3e-01 | 6.1e-01 | 9.6e-01 |
| 388 | (REACTOME) Phosphorylation of Emi1 | 6.5e-01 | 8.8e-01 | 7.3e-01 | 9.0e-01 | 9.1e-01 | 8.4e-01 |
| 1368 | (REACTOME) Neurexins and neuroligins | 6.5e-01 | 1.0e+00 | 7.9e-01 | 9.5e-01 | 6.9e-01 | 7.3e-01 |
| 1573 | (REACTOME) RNA Polymerase III Transcription Initiation From Type 2 Promoter | 6.5e-01 | 5.6e-01 | 6.0e-01 | 8.5e-01 | 3.4e-01 | 1.0e-01 |
| 1700 | (REACTOME) Collagen chain trimerization | 6.5e-01 | 5.0e-02 | 6.1e-01 | 1.0e+00 | 3.3e-01 | 3.0e-02 |
| 86 | (REACTOME) Signaling by ERBB2 in Cancer | 6.5e-01 | 3.8e-01 | 6.0e-01 | 9.0e-01 | 9.9e-01 | 8.2e-01 |
| 423 | (REACTOME) FGFR1 mutant receptor activation | 6.5e-01 | 8.3e-01 | 8.8e-01 | 8.5e-01 | 7.7e-01 | 4.8e-01 |
| 535 | (REACTOME) trans-Golgi Network Vesicle Budding | 6.5e-01 | 9.9e-01 | 7.2e-01 | 9.1e-01 | 2.7e-01 | 7.0e-01 |
| 579 | (REACTOME) Hypusinylation | 6.5e-01 | 8.0e-01 | 6.5e-01 | 9.9e-01 | 5.4e-01 | 8.6e-01 |
| 641 | (REACTOME) Downregulation of TGF-beta receptor signaling | 6.5e-01 | 6.3e-01 | 9.2e-01 | 7.8e-01 | 3.6e-01 | 7.1e-01 |
| 842 | (REACTOME) Unfolded Protein Response (UPR) | 6.5e-01 | 9.9e-01 | 5.4e-01 | 9.4e-01 | 3.4e-01 | 4.3e-01 |
| 893 | (REACTOME) EPHA-mediated growth cone collapse | 6.5e-01 | 6.1e-01 | 7.5e-01 | 8.5e-01 | 7.2e-01 | 3.0e-02 |
| 894 | (REACTOME) Ephrin signaling | 6.5e-01 | 7.8e-01 | 6.0e-01 | 8.5e-01 | 7.4e-01 | 3.6e-01 |
| 895 | (REACTOME) EPH-ephrin mediated repulsion of cells | 6.5e-01 | 5.1e-01 | 8.5e-01 | 8.5e-01 | 4.5e-01 | 1.1e-01 |
| 1353 | (REACTOME) Fanconi Anemia Pathway | 6.5e-01 | 8.7e-01 | 8.6e-01 | 9.2e-01 | 8.5e-01 | 1.4e-01 |
| 1364 | (REACTOME) rRNA modification in the nucleus and cytosol | 6.5e-01 | 5.7e-01 | 2.8e-01 | 1.7e-01 | 8.0e-02 | 2.0e-02 |
| 1702 | (REACTOME) Regulation of PTEN localization | 6.5e-01 | 9.1e-01 | 8.5e-01 | 7.8e-01 | 9.4e-01 | 3.7e-01 |
| 1812 | (REACTOME) Biosynthesis of EPA-derived SPMs | 6.5e-01 | 4.7e-01 | 6.0e-01 | 8.5e-01 | 6.8e-01 | 5.0e-01 |
| 1981 | (REACTOME) Signaling by ERBB2 KD Mutants | 6.5e-01 | 4.1e-01 | 6.0e-01 | 8.9e-01 | 9.9e-01 | 6.9e-01 |
| 1048 | (REACTOME) Asymmetric localization of PCP proteins | 6.5e-01 | 3.3e-01 | 6.2e-01 | 1.0e+00 | 4.5e-01 | 1.4e-01 |
| 402 | (REACTOME) DARPP-32 events | 6.5e-01 | 5.5e-01 | 8.5e-01 | 9.1e-01 | 9.1e-01 | 9.7e-01 |
| 642 | (REACTOME) TGF-beta receptor signaling activates SMADs | 6.5e-01 | 5.7e-01 | 9.2e-01 | 7.8e-01 | 3.7e-01 | 7.3e-01 |
| 1893 | (REACTOME) NTRK3 as a dependence receptor | 6.5e-01 | 7.6e-01 | 9.1e-01 | 8.9e-01 | 7.3e-01 | 7.7e-01 |
| 564 | (REACTOME) FCGR activation | 6.5e-01 | 7.3e-01 | 9.2e-01 | 7.0e-01 | 3.4e-01 | 1.0e-01 |
| 1537 | (REACTOME) RNA Polymerase III Transcription Termination | 6.5e-01 | 4.4e-01 | 7.2e-01 | 8.5e-01 | 1.7e-01 | 6.0e-02 |
| 905 | (REACTOME) Adrenaline,noradrenaline inhibits insulin secretion | 6.5e-01 | 8.7e-01 | 8.6e-01 | 9.4e-01 | 9.4e-01 | 4.9e-01 |
| 1931 | (REACTOME) Infection with Mycobacterium tuberculosis | 6.5e-01 | 4.0e-01 | 8.2e-01 | 9.4e-01 | 8.5e-01 | 6.9e-01 |
| 150 | (REACTOME) Signaling by SCF-KIT | 6.6e-01 | 8.8e-01 | 8.5e-01 | 9.0e-01 | 8.4e-01 | 4.8e-01 |
| 351 | (REACTOME) Frs2-mediated activation | 6.6e-01 | 1.0e+00 | 9.6e-01 | 9.1e-01 | 5.5e-01 | 9.2e-01 |
| 868 | (REACTOME) Beta-oxidation of pristanoyl-CoA | 6.6e-01 | 9.2e-01 | 7.3e-01 | 9.4e-01 | 9.7e-01 | 8.0e-01 |
| 1185 | (REACTOME) Anchoring of the basal body to the plasma membrane | 6.6e-01 | 7.2e-01 | 6.0e-01 | 9.9e-01 | 4.5e-01 | 9.5e-01 |
| 1823 | (REACTOME) Loss of phosphorylation of MECP2 at T308 | 6.6e-01 | 8.4e-01 | 6.1e-01 | 9.8e-01 | 8.1e-01 | 7.9e-01 |
| 1907 | (REACTOME) Regulation of localization of FOXO transcription factors | 6.6e-01 | 9.5e-01 | 9.8e-01 | 8.5e-01 | 3.5e-01 | 2.6e-01 |
| 31 | (REACTOME) Apoptotic cleavage of cellular proteins | 6.6e-01 | 1.8e-01 | 6.3e-01 | 7.8e-01 | 9.7e-01 | 5.7e-01 |
| 566 | (REACTOME) Role of phospholipids in phagocytosis | 6.6e-01 | 4.0e-01 | 9.6e-01 | 9.7e-01 | 3.4e-01 | 5.0e-01 |
| 1423 | (REACTOME) Mitotic Metaphase/Anaphase Transition | 6.6e-01 | 8.1e-01 | 8.7e-01 | 8.5e-01 | 8.0e-01 | 9.8e-01 |
| 1705 | (REACTOME) RUNX3 Regulates Immune Response and Cell Migration | 6.6e-01 | 5.6e-01 | 7.3e-01 | 8.9e-01 | 5.9e-01 | 9.0e-01 |
| 1755 | (REACTOME) Interleukin-35 Signalling | 6.6e-01 | 8.3e-01 | 8.1e-01 | 9.4e-01 | 5.5e-01 | 4.5e-01 |
| 1562 | (REACTOME) TNF signaling | 6.6e-01 | 8.2e-01 | 8.0e-01 | 9.4e-01 | 8.7e-01 | 6.0e-01 |
| 700 | (REACTOME) Insulin processing | 6.6e-01 | 9.4e-01 | 9.7e-01 | 9.4e-01 | 8.6e-01 | 5.5e-01 |
| 1622 | (REACTOME) Signaling by MST1 | 6.6e-01 | 9.2e-01 | 9.6e-01 | 9.4e-01 | 2.7e-01 | 9.7e-01 |
| 1930 | (REACTOME) Suppression of apoptosis | 6.6e-01 | 6.0e-02 | 8.2e-01 | 9.4e-01 | 7.2e-01 | 5.6e-01 |
| 1948 | (REACTOME) N-glycan trimming and elongation in the cis-Golgi | 6.6e-01 | 5.3e-01 | 7.9e-01 | 9.0e-01 | 6.9e-01 | 3.4e-01 |
| 39 | (REACTOME) phospho-PLA2 pathway | 6.6e-01 | 4.1e-01 | 8.3e-01 | 7.8e-01 | 8.3e-01 | 5.3e-01 |
| 98 | (REACTOME) Methionine salvage pathway | 6.6e-01 | 6.5e-01 | 9.0e-01 | 4.7e-01 | 4.2e-01 | 4.1e-01 |
| 276 | (REACTOME) Synthesis of PIPs at the early endosome membrane | 6.6e-01 | 9.1e-01 | 6.0e-01 | 9.9e-01 | 5.6e-01 | 5.7e-01 |
| 588 | (REACTOME) Glycoprotein hormones | 6.6e-01 | 7.9e-01 | 9.0e-01 | 7.8e-01 | 1.7e-01 | 5.7e-01 |
| 732 | (REACTOME) SUMO is transferred from E1 to E2 (UBE2I, UBC9) | 6.6e-01 | 6.3e-01 | 8.2e-01 | 3.0e-01 | 6.9e-01 | 3.7e-01 |
| 997 | (REACTOME) Rhesus glycoproteins mediate ammonium transport. | 6.6e-01 | NA | 9.0e-01 | 1.0e+00 | 7.6e-01 | 6.2e-01 |
| 1143 | (REACTOME) Organic cation transport | 6.6e-01 | 7.7e-01 | 9.0e-01 | 1.0e+00 | 6.9e-01 | 3.5e-01 |
| 1240 | (REACTOME) FRS-mediated FGFR4 signaling | 6.6e-01 | 8.3e-01 | 9.8e-01 | 9.9e-01 | 4.2e-01 | 4.4e-01 |
| 1485 | (REACTOME) Pentose phosphate pathway | 6.6e-01 | 5.4e-01 | 9.1e-01 | 8.5e-01 | 9.3e-01 | 3.3e-01 |
| 1491 | (REACTOME) pre-mRNA splicing | 6.6e-01 | 1.1e-01 | 5.1e-01 | 4.8e-01 | 0.0e+00 | 5.0e-02 |
| 1568 | (REACTOME) Response to elevated platelet cytosolic Ca2+ | 6.6e-01 | 9.2e-01 | 9.4e-01 | 9.4e-01 | 6.6e-01 | 8.8e-01 |
| 1657 | (REACTOME) MET interacts with TNS proteins | 6.6e-01 | 8.9e-01 | 6.2e-01 | 9.4e-01 | 5.2e-01 | 5.4e-01 |
| 1741 | (REACTOME) HDL remodeling | 6.6e-01 | 5.6e-01 | 9.1e-01 | 1.0e+00 | 9.2e-01 | 5.1e-01 |
| 1752 | (REACTOME) Glycogen metabolism | 6.6e-01 | 7.4e-01 | 6.6e-01 | 9.1e-01 | 8.7e-01 | 0.0e+00 |
| 1786 | (REACTOME) RHOQ GTPase cycle | 6.6e-01 | 6.0e-02 | 8.8e-01 | 9.0e-01 | 5.9e-01 | 3.9e-01 |
| 1821 | (REACTOME) Interleukin-27 signaling | 6.6e-01 | 8.1e-01 | 8.0e-01 | 9.4e-01 | 5.2e-01 | 4.8e-01 |
| 2110 | (REACTOME) Aspirin ADME | 6.6e-01 | 2.3e-01 | 8.8e-01 | 3.0e-01 | 9.2e-01 | 1.5e-01 |
| 91 | (REACTOME) Signaling by ERBB4 | 6.6e-01 | 1.7e-01 | 8.2e-01 | 9.2e-01 | 2.7e-01 | 7.2e-01 |
| 217 | (REACTOME) IRF3 mediated activation of type 1 IFN | 6.6e-01 | 2.6e-01 | 8.3e-01 | 9.0e-01 | 8.4e-01 | 6.0e-01 |
| 488 | (REACTOME) Mineralocorticoid biosynthesis | 6.6e-01 | 8.0e-01 | 9.7e-01 | 9.8e-01 | NA | 8.4e-01 |
| 526 | (REACTOME) ERK/MAPK targets | 6.6e-01 | 9.6e-01 | 9.6e-01 | 9.0e-01 | 8.4e-01 | 4.6e-01 |
| 1147 | (REACTOME) Phase 3 - rapid repolarisation | 6.6e-01 | 9.2e-01 | 9.1e-01 | 9.5e-01 | 8.5e-01 | 4.1e-01 |
| 1546 | (REACTOME) Signaling by Insulin receptor | 6.6e-01 | 9.7e-01 | 8.7e-01 | 8.9e-01 | 6.5e-01 | 6.8e-01 |
| 505 | (REACTOME) PI3K events in ERBB2 signaling | 6.6e-01 | 2.3e-01 | 6.0e-01 | 8.9e-01 | 8.1e-01 | 7.3e-01 |
| 736 | (REACTOME) DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 6.6e-01 | 8.0e-01 | 9.1e-01 | 9.4e-01 | 6.1e-01 | 8.4e-01 |
| 844 | (REACTOME) Transcriptional regulation of white adipocyte differentiation | 6.6e-01 | 9.8e-01 | 7.3e-01 | 9.1e-01 | 7.3e-01 | 7.8e-01 |
| 1576 | (REACTOME) Ketone body catabolism | 6.6e-01 | 3.4e-01 | 6.0e-01 | 9.0e-01 | 9.6e-01 | 3.4e-01 |
| 1607 | (REACTOME) Threonine catabolism | 6.6e-01 | 5.7e-01 | 9.9e-01 | 8.5e-01 | 8.0e-01 | 7.1e-01 |
| 1933 | (REACTOME) Inhibition of nitric oxide production | 6.6e-01 | 9.4e-01 | 8.5e-01 | 8.5e-01 | 6.3e-01 | 8.6e-01 |
| 2096 | (REACTOME) Sensory perception of taste | 6.6e-01 | 8.3e-01 | 7.3e-01 | 9.8e-01 | 6.9e-01 | 1.0e+00 |
| 113 | (REACTOME) ATP sensitive Potassium channels | 6.7e-01 | 8.8e-01 | 6.5e-01 | 8.5e-01 | 4.9e-01 | 8.0e-02 |
| 660 | (REACTOME) Metabolism of ingested H2SeO4 and H2SeO3 into H2Se | 6.7e-01 | 9.6e-01 | 8.5e-01 | 9.4e-01 | 7.7e-01 | 5.1e-01 |
| 1112 | (REACTOME) Signaling by RNF43 mutants | 6.7e-01 | 9.9e-01 | 9.4e-01 | 9.5e-01 | 4.8e-01 | 2.6e-01 |
| 2154 | (REACTOME) SUMOylation of nuclear envelope proteins | 6.7e-01 | 8.9e-01 | 8.5e-01 | 9.1e-01 | 7.7e-01 | 7.2e-01 |
| 912 | (REACTOME) Sialic acid metabolism | 6.7e-01 | 8.5e-01 | 8.5e-01 | 8.5e-01 | 8.1e-01 | 1.0e+00 |
| 358 | (REACTOME) Formation of the active cofactor, UDP-glucuronate | 6.7e-01 | 1.5e-01 | 8.0e-01 | 8.3e-01 | 8.7e-01 | 1.5e-01 |
| 1554 | (REACTOME) Triglyceride biosynthesis | 6.7e-01 | 9.3e-01 | 7.6e-01 | 9.1e-01 | 8.9e-01 | 7.9e-01 |
| 917 | (REACTOME) G alpha (q) signalling events | 6.7e-01 | 5.4e-01 | 9.9e-01 | 8.2e-01 | 4.2e-01 | 1.0e-02 |
| 840 | (REACTOME) PERK regulates gene expression | 6.7e-01 | 9.3e-01 | 6.0e-01 | 9.2e-01 | 4.3e-01 | 8.1e-01 |
| 1405 | (REACTOME) PTEN Regulation | 6.7e-01 | 6.3e-01 | 9.7e-01 | 8.9e-01 | 7.2e-01 | 3.7e-01 |
| 731 | (REACTOME) SUMO is conjugated to E1 (UBA2:SAE1) | 6.7e-01 | 8.0e-01 | 8.2e-01 | 3.0e-01 | 3.1e-01 | 3.6e-01 |
| 1890 | (REACTOME) Molybdenum cofactor biosynthesis | 6.7e-01 | 8.9e-01 | 6.0e-01 | 8.5e-01 | 7.5e-01 | 7.9e-01 |
| 1647 | (REACTOME) Activation of the TFAP2 (AP-2) family of transcription factors | 6.8e-01 | 8.8e-01 | 8.5e-01 | 8.5e-01 | 9.1e-01 | 6.2e-01 |
| 138 | (REACTOME) Apoptosis induced DNA fragmentation | 6.8e-01 | 5.4e-01 | 8.1e-01 | 8.5e-01 | 8.8e-01 | 7.3e-01 |
| 2084 | (REACTOME) Regulation of HMOX1 expression and activity | 6.8e-01 | 9.8e-01 | 7.9e-01 | 9.1e-01 | 3.3e-01 | 6.4e-01 |
| 1089 | (REACTOME) Regulated Necrosis | 6.8e-01 | 9.1e-01 | 7.2e-01 | 7.8e-01 | 8.4e-01 | 8.9e-01 |
| 1964 | (REACTOME) ADORA2B mediated anti-inflammatory cytokines production | 6.8e-01 | 8.1e-01 | 9.6e-01 | 1.0e+00 | 8.9e-01 | 2.2e-01 |
| 1392 | (REACTOME) Regulation of TP53 Activity through Phosphorylation | 6.8e-01 | 5.7e-01 | 8.3e-01 | 9.0e-01 | 6.9e-01 | 1.0e-01 |
| 283 | (REACTOME) The activation of arylsulfatases | 6.9e-01 | 8.1e-01 | 8.5e-01 | 9.4e-01 | 6.5e-01 | 7.3e-01 |
| 2107 | (REACTOME) SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 6.9e-01 | 6.9e-01 | 8.7e-01 | 9.7e-01 | 4.3e-01 | 2.3e-01 |
| 856 | (REACTOME) GSD IV | 6.9e-01 | 9.5e-01 | 1.0e+00 | 9.8e-01 | 7.7e-01 | 3.7e-01 |
| 792 | (REACTOME) Loss of Function of TGFBR2 in Cancer | 6.9e-01 | 4.9e-01 | 6.6e-01 | 7.8e-01 | 8.4e-01 | 2.4e-01 |
| 793 | (REACTOME) TGFBR2 Kinase Domain Mutants in Cancer | 6.9e-01 | 4.9e-01 | 6.6e-01 | 7.8e-01 | 8.4e-01 | 2.4e-01 |
| 799 | (REACTOME) TGFBR1 KD Mutants in Cancer | 6.9e-01 | 4.9e-01 | 6.6e-01 | 7.8e-01 | 8.4e-01 | 2.4e-01 |
| 1920 | (REACTOME) LXRs regulate gene expression to control bile acid homeostasis | 6.9e-01 | 7.8e-01 | 8.7e-01 | 9.4e-01 | 7.1e-01 | 2.8e-01 |
| 2126 | (REACTOME) SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 6.9e-01 | 8.2e-01 | 8.6e-01 | 9.4e-01 | 6.2e-01 | 3.7e-01 |
| 862 | (REACTOME) CD28 dependent PI3K/Akt signaling | 6.9e-01 | 1.7e-01 | 8.5e-01 | 9.9e-01 | 7.1e-01 | 9.5e-01 |
| 1448 | (REACTOME) Cyclin A/B1/B2 associated events during G2/M transition | 6.9e-01 | 6.1e-01 | 6.5e-01 | 8.5e-01 | 5.7e-01 | 9.4e-01 |
| 162 | (REACTOME) Collagen formation | 6.9e-01 | 2.0e-02 | 6.0e-01 | 1.0e+00 | 4.8e-01 | 0.0e+00 |
| 958 | (REACTOME) SIRT1 negatively regulates rRNA expression | 6.9e-01 | 1.0e+00 | 6.3e-01 | 9.4e-01 | 3.2e-01 | 1.0e+00 |
| 249 | (REACTOME) ChREBP activates metabolic gene expression | 6.9e-01 | 3.3e-01 | 8.5e-01 | 9.4e-01 | 9.4e-01 | 7.2e-01 |
| 2129 | (REACTOME) Prednisone ADME | 6.9e-01 | 8.0e-01 | 7.6e-01 | 7.8e-01 | 3.3e-01 | 8.0e-01 |
| 1955 | (REACTOME) Signaling by MAP2K mutants | 6.9e-01 | 8.6e-01 | 9.9e-01 | 8.5e-01 | 8.5e-01 | 8.1e-01 |
| 550 | (REACTOME) HS-GAG biosynthesis | 6.9e-01 | 6.7e-01 | 7.1e-01 | 9.1e-01 | 6.1e-01 | 3.6e-01 |
| 1302 | (REACTOME) HDR through Single Strand Annealing (SSA) | 6.9e-01 | 7.8e-01 | 6.0e-01 | 9.4e-01 | 7.6e-01 | 9.4e-01 |
| 1329 | (REACTOME) Presynaptic phase of homologous DNA pairing and strand exchange | 6.9e-01 | 7.9e-01 | 5.2e-01 | 7.8e-01 | 3.0e-01 | 1.0e+00 |
| 2016 | (REACTOME) Diseases of DNA repair | 6.9e-01 | 7.9e-01 | 5.2e-01 | 7.8e-01 | 3.0e-01 | 1.0e+00 |
| 2017 | (REACTOME) Diseases of DNA Double-Strand Break Repair | 6.9e-01 | 7.9e-01 | 5.2e-01 | 7.8e-01 | 3.0e-01 | 1.0e+00 |
| 2065 | (REACTOME) Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 6.9e-01 | 7.9e-01 | 5.2e-01 | 7.8e-01 | 3.0e-01 | 1.0e+00 |
| 1753 | (REACTOME) Interleukin-15 signaling | 6.9e-01 | 8.8e-01 | 8.4e-01 | 9.0e-01 | 3.7e-01 | 9.2e-01 |
| 1793 | (REACTOME) RHOBTB1 GTPase cycle | 6.9e-01 | 3.8e-01 | 7.0e-01 | 8.5e-01 | 6.7e-01 | 7.6e-01 |
| 654 | (REACTOME) Crosslinking of collagen fibrils | 6.9e-01 | 4.0e-01 | 9.3e-01 | 9.4e-01 | 6.9e-01 | 1.0e-01 |
| 808 | (REACTOME) Nephrin family interactions | 6.9e-01 | 9.2e-01 | 9.4e-01 | 8.5e-01 | 8.4e-01 | 8.1e-01 |
| 1115 | (REACTOME) TNFR1-induced proapoptotic signaling | 6.9e-01 | 5.7e-01 | 8.5e-01 | 9.4e-01 | 7.1e-01 | 5.2e-01 |
| 1156 | (REACTOME) Defective CYP11A1 causes AICSR | 6.9e-01 | 9.0e-01 | 8.0e-01 | 9.4e-01 | 9.8e-01 | 5.4e-01 |
| 1709 | (REACTOME) RUNX3 regulates WNT signaling | 6.9e-01 | 2.0e-02 | 8.9e-01 | 3.4e-01 | 8.2e-01 | 2.8e-01 |
| 609 | (REACTOME) Phase I - Functionalization of compounds | 6.9e-01 | 6.3e-01 | 9.3e-01 | 8.5e-01 | 4.2e-01 | 2.6e-01 |
| 1024 | (REACTOME) Other interleukin signaling | 7.0e-01 | 5.3e-01 | 9.2e-01 | 7.0e-01 | 8.4e-01 | 1.5e-01 |
| 672 | (REACTOME) Establishment of Sister Chromatid Cohesion | 7.0e-01 | 5.8e-01 | 9.2e-01 | 9.4e-01 | 9.4e-01 | 3.0e-01 |
| 769 | (REACTOME) HSP90 chaperone cycle for SHRs | 7.0e-01 | 3.5e-01 | 6.0e-01 | 8.5e-01 | 8.9e-01 | 7.9e-01 |
| 1824 | (REACTOME) Loss of MECP2 binding ability to the NCoR/SMRT complex | 7.0e-01 | 7.5e-01 | 9.2e-01 | 9.2e-01 | 9.2e-01 | 7.1e-01 |
| 2080 | (REACTOME) FLT3 signaling through SRC family kinases | 7.0e-01 | 7.0e-01 | 8.7e-01 | 8.4e-01 | 4.4e-01 | 1.4e-01 |
| 1341 | (REACTOME) Presynaptic nicotinic acetylcholine receptors | 7.0e-01 | 9.0e-01 | 9.7e-01 | 9.0e-01 | 7.7e-01 | 5.3e-01 |
| 513 | (REACTOME) Vitamin C (ascorbate) metabolism | 7.0e-01 | 6.1e-01 | 9.8e-01 | 8.5e-01 | 6.2e-01 | 2.5e-01 |
| 1746 | (REACTOME) G beta:gamma signalling through CDC42 | 7.0e-01 | 6.7e-01 | 4.7e-01 | 9.8e-01 | 9.1e-01 | 4.3e-01 |
| 1814 | (REACTOME) Biosynthesis of DPA-derived SPMs | 7.0e-01 | 3.3e-01 | 8.9e-01 | 9.9e-01 | 6.9e-01 | 4.4e-01 |
| 1835 | (REACTOME) Biosynthesis of DPAn-3 SPMs | 7.0e-01 | 3.3e-01 | 8.9e-01 | 9.9e-01 | 6.9e-01 | 4.4e-01 |
| 211 | (REACTOME) Recycling of bile acids and salts | 7.0e-01 | 6.3e-01 | 8.0e-01 | 3.4e-01 | 8.4e-01 | 7.8e-01 |
| 373 | (REACTOME) Telomere C-strand synthesis initiation | 7.0e-01 | 5.2e-01 | 8.5e-01 | 8.6e-01 | 7.6e-01 | 8.4e-01 |
| 476 | (REACTOME) Estrogen biosynthesis | 7.0e-01 | 8.1e-01 | 8.7e-01 | 4.6e-01 | 9.4e-01 | 8.1e-01 |
| 477 | (REACTOME) Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 7.0e-01 | 9.9e-01 | 6.3e-01 | 3.0e-01 | 7.7e-01 | 6.6e-01 |
| 735 | (REACTOME) SUMO E3 ligases SUMOylate target proteins | 7.0e-01 | 9.0e-01 | 9.1e-01 | 9.4e-01 | 2.7e-01 | 8.9e-01 |
| 931 | (REACTOME) DCC mediated attractive signaling | 7.0e-01 | 5.4e-01 | 8.7e-01 | 8.5e-01 | 7.3e-01 | 4.9e-01 |
| 976 | (REACTOME) Lysosome Vesicle Biogenesis | 7.0e-01 | 6.0e-01 | 6.2e-01 | 9.9e-01 | 6.7e-01 | 7.2e-01 |
| 1725 | (REACTOME) Tyrosine catabolism | 7.0e-01 | 8.1e-01 | 9.4e-01 | 7.8e-01 | 8.9e-01 | 6.8e-01 |
| 1853 | (REACTOME) NTRK2 activates RAC1 | 7.0e-01 | 5.4e-01 | 8.0e-01 | 9.7e-01 | 1.0e+00 | 4.4e-01 |
| 1924 | (REACTOME) Constitutive Signaling by Overexpressed ERBB2 | 7.0e-01 | 8.3e-01 | 7.9e-01 | 9.4e-01 | 7.9e-01 | 7.6e-01 |
| 260 | (REACTOME) 2-LTR circle formation | 7.0e-01 | 8.1e-01 | 8.1e-01 | 8.9e-01 | 5.5e-01 | 8.8e-01 |
| 447 | (REACTOME) FGFR3 ligand binding and activation | 7.0e-01 | 9.1e-01 | 9.6e-01 | 9.8e-01 | 2.7e-01 | 7.4e-01 |
| 453 | (REACTOME) FGFR3c ligand binding and activation | 7.0e-01 | 9.1e-01 | 9.6e-01 | 9.8e-01 | 2.7e-01 | 7.4e-01 |
| 695 | (REACTOME) FBXW7 Mutants and NOTCH1 in Cancer | 7.0e-01 | 3.9e-01 | 8.3e-01 | 9.0e-01 | 5.6e-01 | 8.4e-01 |
| 697 | (REACTOME) Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 7.0e-01 | 3.9e-01 | 8.3e-01 | 9.0e-01 | 5.6e-01 | 8.4e-01 |
| 752 | (REACTOME) Defects in cobalamin (B12) metabolism | 7.0e-01 | 4.0e-01 | 6.0e-01 | 9.2e-01 | 9.2e-01 | 8.5e-01 |
| 1639 | (REACTOME) MET activates PTPN11 | 7.0e-01 | 8.1e-01 | 7.4e-01 | 9.0e-01 | 2.6e-01 | 2.4e-01 |
| 2034 | (REACTOME) Maturation of spike protein_1 | 7.0e-01 | 8.4e-01 | 8.8e-01 | 9.0e-01 | 6.4e-01 | 5.1e-01 |
| 125 | (REACTOME) GRB7 events in ERBB2 signaling | 7.0e-01 | 5.0e-02 | 5.2e-01 | 9.7e-01 | 5.3e-01 | 5.9e-01 |
| 302 | (REACTOME) Abortive elongation of HIV-1 transcript in the absence of Tat | 7.0e-01 | 3.8e-01 | 9.6e-01 | 8.5e-01 | 3.4e-01 | 1.5e-01 |
| 541 | (REACTOME) Formation of the beta-catenin:TCF transactivating complex | 7.0e-01 | 5.3e-01 | 9.5e-01 | 9.4e-01 | 6.6e-01 | 8.6e-01 |
| 673 | (REACTOME) Cohesin Loading onto Chromatin | 7.0e-01 | 4.7e-01 | 9.4e-01 | 9.5e-01 | 8.4e-01 | 3.2e-01 |
| 705 | (REACTOME) Signaling by NOTCH1 HD Domain Mutants in Cancer | 7.0e-01 | 4.0e-01 | 9.1e-01 | 3.0e-01 | 6.9e-01 | 7.0e-01 |
| 706 | (REACTOME) Constitutive Signaling by NOTCH1 HD Domain Mutants | 7.0e-01 | 4.0e-01 | 9.1e-01 | 3.0e-01 | 6.9e-01 | 7.0e-01 |
| 829 | (REACTOME) Chemokine receptors bind chemokines | 7.0e-01 | 1.1e-01 | 6.2e-01 | 6.3e-01 | 1.6e-01 | 0.0e+00 |
| 866 | (REACTOME) Alpha-oxidation of phytanate | 7.0e-01 | 6.1e-01 | 8.3e-01 | 9.5e-01 | 7.9e-01 | 7.9e-01 |
| 927 | (REACTOME) G alpha (s) signalling events | 7.0e-01 | 7.2e-01 | 6.0e-01 | 9.8e-01 | 7.0e-01 | 3.0e-02 |
| 1284 | (REACTOME) Negative feedback regulation of MAPK pathway | 7.0e-01 | 9.7e-01 | 8.3e-01 | 9.4e-01 | 6.9e-01 | 8.1e-01 |
| 1354 | (REACTOME) Interleukin-6 family signaling | 7.0e-01 | 5.6e-01 | 8.3e-01 | 8.5e-01 | 7.4e-01 | 6.6e-01 |
| 1377 | (REACTOME) Signaling by BRAF and RAF1 fusions | 7.0e-01 | 9.2e-01 | 9.6e-01 | 1.0e+00 | 6.4e-01 | 8.2e-01 |
| 1494 | (REACTOME) mRNA 3’-end processing | 7.0e-01 | 5.9e-01 | 6.0e-01 | 7.8e-01 | 1.4e-01 | 4.7e-01 |
| 1740 | (REACTOME) VLDL clearance | 7.0e-01 | 9.1e-01 | 8.3e-01 | 9.1e-01 | 8.3e-01 | 5.6e-01 |
| 2149 | (REACTOME) Late SARS-CoV-2 Infection Events | 7.0e-01 | 8.1e-01 | 6.0e-01 | 7.8e-01 | 7.3e-01 | 6.8e-01 |
| 622 | (REACTOME) Synthesis of 5-eicosatetraenoic acids | 7.0e-01 | 8.9e-01 | 9.5e-01 | 9.9e-01 | 8.5e-01 | 4.1e-01 |
| 667 | (REACTOME) Retinoid cycle disease events | 7.0e-01 | 9.1e-01 | 9.6e-01 | 9.4e-01 | 8.2e-01 | 4.8e-01 |
| 675 | (REACTOME) Diseases associated with visual transduction | 7.0e-01 | 9.1e-01 | 9.6e-01 | 9.4e-01 | 8.2e-01 | 4.8e-01 |
| 2018 | (REACTOME) Diseases of the neuronal system | 7.0e-01 | 9.1e-01 | 9.6e-01 | 9.4e-01 | 8.2e-01 | 4.8e-01 |
| 129 | (REACTOME) Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | 7.0e-01 | 1.0e+00 | 8.7e-01 | 9.5e-01 | 9.5e-01 | 1.0e+00 |
| 189 | (REACTOME) Methylation | 7.0e-01 | 8.0e-01 | 6.0e-01 | 8.5e-01 | 4.0e-01 | 9.7e-01 |
| 811 | (REACTOME) NCAM signaling for neurite out-growth | 7.0e-01 | 4.6e-01 | 6.3e-01 | 9.9e-01 | 9.9e-01 | 3.5e-01 |
| 1088 | (REACTOME) RIPK1-mediated regulated necrosis | 7.0e-01 | 8.9e-01 | 7.5e-01 | 8.4e-01 | 8.2e-01 | 8.9e-01 |
| 1317 | (REACTOME) DNA Double-Strand Break Repair | 7.0e-01 | 8.4e-01 | 9.0e-02 | 8.5e-01 | 4.5e-01 | 4.0e-02 |
| 1868 | (REACTOME) Interleukin receptor SHC signaling | 7.0e-01 | 4.3e-01 | 9.3e-01 | 9.8e-01 | 3.4e-01 | 6.3e-01 |
| 343 | (REACTOME) Inhibition of PKR | 7.0e-01 | 9.8e-01 | 7.8e-01 | 8.5e-01 | 8.6e-01 | 8.3e-01 |
| 1286 | (REACTOME) Regulation of necroptotic cell death | 7.1e-01 | 8.8e-01 | 8.0e-01 | 7.9e-01 | 6.6e-01 | 8.4e-01 |
| 906 | (REACTOME) Regulation of lipid metabolism by PPARalpha | 7.1e-01 | 9.3e-01 | 6.4e-01 | 8.7e-01 | 9.6e-01 | 6.9e-01 |
| 1303 | (REACTOME) HDR through MMEJ (alt-NHEJ) | 7.1e-01 | 9.0e-01 | 6.0e-01 | 8.5e-01 | 5.7e-01 | 6.5e-01 |
| 1850 | (REACTOME) LXRs regulate gene expression linked to triglyceride lipolysis in adipose | 7.1e-01 | 8.8e-01 | 8.6e-01 | 9.4e-01 | 3.7e-01 | 6.8e-01 |
| 348 | (REACTOME) Adenylate cyclase inhibitory pathway | 7.1e-01 | 2.1e-01 | 9.6e-01 | 9.1e-01 | 8.0e-01 | 6.6e-01 |
| 683 | (REACTOME) Oxidative Stress Induced Senescence | 7.1e-01 | 8.3e-01 | 6.3e-01 | 9.7e-01 | 7.7e-01 | 3.9e-01 |
| 937 | (REACTOME) Calcitonin-like ligand receptors | 7.1e-01 | 8.9e-01 | 8.9e-01 | 9.4e-01 | 9.3e-01 | 3.7e-01 |
| 275 | (REACTOME) Synthesis of PIPs at the Golgi membrane | 7.1e-01 | 9.7e-01 | 7.6e-01 | 7.8e-01 | 7.2e-01 | 9.5e-01 |
| 1521 | (REACTOME) RNA Polymerase II Transcription Termination | 7.1e-01 | 5.2e-01 | 6.0e-01 | 7.8e-01 | 2.1e-01 | 4.5e-01 |
| 286 | (REACTOME) Lectin pathway of complement activation | 7.1e-01 | 6.2e-01 | 8.2e-01 | 9.0e-01 | 7.9e-01 | 7.7e-01 |
| 1265 | (REACTOME) CLEC7A/inflammasome pathway | 7.1e-01 | 9.4e-01 | 9.1e-01 | 8.5e-01 | 6.5e-01 | 5.8e-01 |
| 1996 | (REACTOME) Defective factor IX causes hemophilia B | 7.1e-01 | 9.8e-01 | 9.7e-01 | 9.9e-01 | 9.3e-01 | 3.1e-01 |
| 1658 | (REACTOME) MET activates RAP1 and RAC1 | 7.1e-01 | 8.2e-01 | 8.7e-01 | 1.0e+00 | 4.5e-01 | 3.3e-01 |
| 370 | (REACTOME) Polymerase switching on the C-strand of the telomere | 7.1e-01 | 5.6e-01 | 6.6e-01 | 7.8e-01 | 3.5e-01 | 8.9e-01 |
| 173 | (REACTOME) Hydrolysis of LPE | 7.2e-01 | 5.3e-01 | 6.0e-01 | 9.9e-01 | 3.5e-01 | 3.6e-01 |
| 2125 | (REACTOME) N-glycan antennae elongation in the medial/trans-Golgi | 7.2e-01 | 9.1e-01 | 9.6e-01 | 9.4e-01 | 9.4e-01 | 4.0e-01 |
| 2127 | (REACTOME) Reactions specific to the complex N-glycan synthesis pathway | 7.2e-01 | 9.1e-01 | 9.6e-01 | 9.4e-01 | 9.4e-01 | 4.0e-01 |
| 34 | (REACTOME) Opioid Signalling | 7.2e-01 | 9.5e-01 | 9.6e-01 | 9.4e-01 | 7.3e-01 | 6.0e-01 |
| 2082 | (REACTOME) RHOBTB GTPase Cycle | 7.2e-01 | 3.7e-01 | 7.1e-01 | 8.5e-01 | 6.4e-01 | 7.3e-01 |
| 442 | (REACTOME) Cellular hexose transport | 7.2e-01 | 8.1e-01 | 9.2e-01 | 8.0e-01 | 5.1e-01 | 5.3e-01 |
| 2090 | (REACTOME) Sensory Perception | 7.2e-01 | 9.9e-01 | 6.1e-01 | 9.0e-01 | 5.9e-01 | 9.2e-01 |
| 1082 | (REACTOME) WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 7.2e-01 | 3.6e-01 | 9.7e-01 | 8.0e-01 | 4.6e-01 | 9.4e-01 |
| 1243 | (REACTOME) PI-3K cascade:FGFR4 | 7.2e-01 | 8.3e-01 | 9.7e-01 | 9.6e-01 | 3.4e-01 | 4.4e-01 |
| 1827 | (REACTOME) MECP2 regulates neuronal receptors and channels | 7.2e-01 | 3.3e-01 | 8.9e-01 | 8.2e-01 | 8.4e-01 | 6.0e-01 |
| 577 | (REACTOME) Linoleic acid (LA) metabolism | 7.2e-01 | 9.1e-01 | 7.8e-01 | 9.1e-01 | 9.3e-01 | 4.0e-02 |
| 1247 | (REACTOME) Negative regulation of FGFR4 signaling | 7.2e-01 | 6.5e-01 | 9.8e-01 | 9.4e-01 | 3.3e-01 | 4.6e-01 |
| 807 | (REACTOME) Netrin-1 signaling | 7.2e-01 | 4.5e-01 | 7.8e-01 | 9.3e-01 | 9.2e-01 | 7.1e-01 |
| 143 | (REACTOME) Formation of Fibrin Clot (Clotting Cascade) | 7.3e-01 | 1.0e+00 | 9.5e-01 | 9.4e-01 | 9.7e-01 | 2.0e-02 |
| 285 | (REACTOME) Complement cascade | 7.3e-01 | 7.4e-01 | 9.6e-01 | 7.0e-01 | 6.9e-01 | 9.0e-02 |
| 879 | (REACTOME) Striated Muscle Contraction | 7.3e-01 | 6.1e-01 | 9.7e-01 | 8.5e-01 | 6.4e-01 | 3.8e-01 |
| 2051 | (REACTOME) Maturation of spike protein_2 | 7.3e-01 | 9.5e-01 | 8.3e-01 | 1.0e+00 | 9.9e-01 | 4.5e-01 |
| 1251 | (REACTOME) Signaling by FGFR4 | 7.3e-01 | 8.1e-01 | 9.7e-01 | 9.1e-01 | 3.8e-01 | 2.7e-01 |
| 1351 | (REACTOME) tRNA modification in the nucleus and cytosol | 7.3e-01 | 1.7e-01 | 6.2e-01 | 8.5e-01 | 3.2e-01 | 1.1e-01 |
| 372 | (REACTOME) Telomere C-strand (Lagging Strand) Synthesis | 7.3e-01 | 4.7e-01 | 6.0e-01 | 7.8e-01 | 4.2e-01 | 8.4e-01 |
| 1483 | (REACTOME) Creatine metabolism | 7.3e-01 | 8.2e-01 | 8.3e-01 | 1.0e+00 | 8.6e-01 | 3.9e-01 |
| 1954 | (REACTOME) Defects of Formation of Fibrin Clot (Clotting Cascade) | 7.3e-01 | 1.0e+00 | 9.6e-01 | 9.5e-01 | 8.9e-01 | 1.3e-01 |
| 2002 | (REACTOME) Diseases of hemostasis | 7.3e-01 | 1.0e+00 | 9.6e-01 | 9.5e-01 | 8.9e-01 | 1.3e-01 |
| 858 | (REACTOME) Vasopressin-like receptors | 7.3e-01 | 9.6e-01 | 9.8e-01 | 8.5e-01 | 6.9e-01 | 6.6e-01 |
| 257 | (REACTOME) PKA activation in glucagon signalling | 7.3e-01 | 7.0e-01 | 9.4e-01 | 9.7e-01 | 9.1e-01 | 7.1e-01 |
| 512 | (REACTOME) Vitamin B1 (thiamin) metabolism | 7.3e-01 | 3.1e-01 | 7.8e-01 | 7.8e-01 | 8.2e-01 | 7.8e-01 |
| 1092 | (REACTOME) VEGFR2 mediated cell proliferation | 7.3e-01 | 6.1e-01 | 9.6e-01 | 9.6e-01 | 8.4e-01 | 7.1e-01 |
| 1381 | (REACTOME) Antimicrobial peptides | 7.3e-01 | 7.2e-01 | 8.6e-01 | 9.4e-01 | 7.2e-01 | 7.2e-01 |
| 2032 | (REACTOME) Maturation of protein 3a_1 | 7.3e-01 | 8.8e-01 | 9.6e-01 | 9.4e-01 | 7.7e-01 | 8.7e-01 |
| 2058 | (REACTOME) Maturation of protein 3a_2 | 7.3e-01 | 8.8e-01 | 9.6e-01 | 9.4e-01 | 7.7e-01 | 8.7e-01 |
| 409 | (REACTOME) Extension of Telomeres | 7.3e-01 | 4.7e-01 | 6.2e-01 | 8.2e-01 | 4.2e-01 | 7.9e-01 |
| 439 | (REACTOME) Signalling to ERKs | 7.3e-01 | 9.9e-01 | 9.6e-01 | 9.8e-01 | 3.5e-01 | 4.1e-01 |
| 529 | (REACTOME) PPARA activates gene expression | 7.3e-01 | 9.2e-01 | 6.2e-01 | 8.7e-01 | 9.7e-01 | 6.9e-01 |
| 658 | (REACTOME) Metabolism of ingested SeMet, Sec, MeSec into H2Se | 7.3e-01 | 5.1e-01 | 8.6e-01 | 3.8e-01 | 4.3e-01 | 1.0e+00 |
| 936 | (REACTOME) NCAM1 interactions | 7.3e-01 | 4.0e-01 | 6.4e-01 | 1.0e+00 | 9.5e-01 | 2.5e-01 |
| 1017 | (REACTOME) NrCAM interactions | 7.3e-01 | 5.6e-01 | 8.3e-01 | 7.8e-01 | 2.1e-01 | 5.6e-01 |
| 1071 | (REACTOME) Defective GALNT3 causes HFTC | 7.3e-01 | 9.5e-01 | 6.0e-01 | 8.5e-01 | 8.2e-01 | 9.5e-01 |
| 1120 | (REACTOME) Signaling by Hedgehog | 7.3e-01 | 8.9e-01 | 7.9e-01 | 9.8e-01 | 6.0e-01 | 3.1e-01 |
| 1204 | (REACTOME) RHO GTPases activate PAKs | 7.3e-01 | 6.6e-01 | 7.1e-01 | 1.0e+00 | 5.1e-01 | 6.0e-01 |
| 1219 | (REACTOME) PCNA-Dependent Long Patch Base Excision Repair | 7.3e-01 | 3.5e-01 | 7.7e-01 | 9.4e-01 | 6.9e-01 | 5.4e-01 |
| 1825 | (REACTOME) Loss of MECP2 binding ability to 5mC-DNA | 7.3e-01 | 9.3e-01 | 9.2e-01 | 9.1e-01 | 8.7e-01 | 9.1e-01 |
| 1839 | (REACTOME) Activated NTRK2 signals through RAS | 7.3e-01 | 5.8e-01 | 8.2e-01 | 9.1e-01 | 6.7e-01 | 7.9e-01 |
| 1852 | (REACTOME) Activated NTRK2 signals through FYN | 7.3e-01 | 5.7e-01 | 8.3e-01 | 9.5e-01 | 7.9e-01 | 4.2e-01 |
| 1870 | (REACTOME) Regulation of IFNA/IFNB signaling | 7.3e-01 | 8.1e-01 | 6.7e-01 | 8.5e-01 | 8.7e-01 | 6.9e-01 |
| 1936 | (REACTOME) Suppression of autophagy | 7.3e-01 | 8.1e-01 | 7.1e-01 | 9.5e-01 | 9.2e-01 | 5.7e-01 |
| 1947 | (REACTOME) Aggrephagy | 7.3e-01 | 6.5e-01 | 9.5e-01 | 9.1e-01 | 9.2e-01 | 2.4e-01 |
| 1958 | (REACTOME) Signaling by RAF1 mutants | 7.3e-01 | 9.1e-01 | 9.7e-01 | 8.5e-01 | 9.4e-01 | 8.7e-01 |
| 2062 | (REACTOME) RND1 GTPase cycle | 7.3e-01 | 6.4e-01 | 8.8e-01 | 8.3e-01 | 8.5e-01 | 8.4e-01 |
| 810 | (REACTOME) L1CAM interactions | 7.3e-01 | 7.3e-01 | 8.5e-01 | 9.5e-01 | 6.9e-01 | 7.0e-02 |
| 632 | (REACTOME) Integrin cell surface interactions | 7.3e-01 | 4.3e-01 | 6.0e-01 | 9.5e-01 | 7.3e-01 | 0.0e+00 |
| 783 | (REACTOME) Breakdown of the nuclear lamina | 7.3e-01 | 7.1e-01 | 8.5e-01 | 8.5e-01 | 7.7e-01 | 6.2e-01 |
| 991 | (REACTOME) CREB1 phosphorylation through the activation of Adenylate Cyclase | 7.3e-01 | 7.6e-01 | 9.3e-01 | 9.4e-01 | 9.4e-01 | 4.4e-01 |
| 1858 | (REACTOME) ABO blood group biosynthesis | 7.3e-01 | 8.1e-01 | 8.5e-01 | 9.4e-01 | 8.6e-01 | 7.9e-01 |
| 1641 | (REACTOME) VLDL assembly | 7.3e-01 | 6.0e-01 | 8.5e-01 | 1.0e+00 | 4.8e-01 | 9.0e-01 |
| 237 | (REACTOME) Post-translational modification: synthesis of GPI-anchored proteins | 7.4e-01 | 1.0e+00 | 8.6e-01 | 9.4e-01 | 8.8e-01 | 9.4e-01 |
| 100 | (REACTOME) SHC1 events in ERBB2 signaling | 7.4e-01 | 3.3e-01 | 6.0e-01 | 9.0e-01 | 9.9e-01 | 4.2e-01 |
| 1249 | (REACTOME) Signaling by FGFR2 | 7.4e-01 | 6.3e-01 | 8.5e-01 | 9.1e-01 | 4.3e-01 | 2.9e-01 |
| 337 | (REACTOME) NOD1/2 Signaling Pathway | 7.4e-01 | 9.3e-01 | 1.0e+00 | 9.4e-01 | 6.5e-01 | 2.6e-01 |
| 377 | (REACTOME) Activation of C3 and C5 | 7.4e-01 | 8.9e-01 | 9.6e-01 | 9.1e-01 | 7.7e-01 | 6.1e-01 |
| 471 | (REACTOME) vRNA Synthesis | 7.4e-01 | 4.8e-01 | 6.0e-01 | 9.6e-01 | 7.2e-01 | 5.3e-01 |
| 499 | (REACTOME) Signaling by WNT | 7.4e-01 | 8.8e-01 | 6.0e-01 | 1.0e+00 | 6.9e-01 | 6.3e-01 |
| 558 | (REACTOME) Generation of second messenger molecules | 7.4e-01 | 7.2e-01 | 6.0e-01 | 1.0e+00 | 8.9e-01 | 1.8e-01 |
| 890 | (REACTOME) Signal amplification | 7.4e-01 | 8.4e-01 | 8.3e-01 | 9.2e-01 | 7.6e-01 | 7.2e-01 |
| 970 | (REACTOME) mRNA decay by 3’ to 5’ exoribonuclease | 7.4e-01 | 5.6e-01 | 9.2e-01 | 9.6e-01 | 6.4e-01 | 5.6e-01 |
| 990 | (REACTOME) Na+/Cl- dependent neurotransmitter transporters | 7.4e-01 | 9.6e-01 | 9.1e-01 | 9.3e-01 | 8.0e-01 | 1.1e-01 |
| 1055 | (REACTOME) SUMOylation of DNA methylation proteins | 7.4e-01 | 9.6e-01 | 9.6e-01 | 9.4e-01 | 6.1e-01 | 7.1e-01 |
| 1630 | (REACTOME) Interleukin-20 family signaling | 7.4e-01 | 8.7e-01 | 9.1e-01 | 9.5e-01 | 5.0e-01 | 7.6e-01 |
| 1704 | (REACTOME) Mitochondrial calcium ion transport | 7.4e-01 | 4.1e-01 | 9.7e-01 | 8.4e-01 | 6.9e-01 | 4.4e-01 |
| 1800 | (REACTOME) NOTCH4 Intracellular Domain Regulates Transcription | 7.4e-01 | 8.1e-01 | 9.3e-01 | 9.4e-01 | 9.4e-01 | 5.0e-01 |
| 215 | (REACTOME) Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | 7.4e-01 | 9.2e-01 | 9.9e-01 | 9.2e-01 | 6.3e-01 | 6.8e-01 |
| 861 | (REACTOME) CD28 co-stimulation | 7.4e-01 | 3.1e-01 | 7.3e-01 | 9.8e-01 | 7.0e-01 | 7.6e-01 |
| 1911 | (REACTOME) Postmitotic nuclear pore complex (NPC) reformation | 7.4e-01 | 6.1e-01 | 8.6e-01 | 1.0e+00 | 9.3e-01 | 3.1e-01 |
| 448 | (REACTOME) FGFR2 ligand binding and activation | 7.4e-01 | 8.8e-01 | 9.7e-01 | 8.8e-01 | 6.4e-01 | 7.9e-01 |
| 360 | (REACTOME) Alternative complement activation | 7.4e-01 | 9.3e-01 | 1.0e+00 | 9.9e-01 | 6.9e-01 | 5.6e-01 |
| 897 | (REACTOME) G-protein beta:gamma signalling | 7.4e-01 | 8.9e-01 | 6.0e-01 | 9.2e-01 | 5.9e-01 | 4.3e-01 |
| 977 | (REACTOME) Golgi Associated Vesicle Biogenesis | 7.4e-01 | 9.2e-01 | 7.3e-01 | 9.0e-01 | 2.8e-01 | 8.9e-01 |
| 317 | (REACTOME) Influenza Infection | 7.4e-01 | 0.0e+00 | 9.6e-01 | 9.9e-01 | 3.0e-01 | 1.0e-02 |
| 520 | (REACTOME) Signaling by NOTCH2 | 7.5e-01 | 5.3e-01 | 1.0e+00 | 5.5e-01 | 7.3e-01 | 7.6e-01 |
| 923 | (REACTOME) G beta:gamma signalling through PLC beta | 7.5e-01 | 8.9e-01 | 9.8e-01 | 9.6e-01 | 7.2e-01 | 3.2e-01 |
| 1068 | (REACTOME) Presynaptic function of Kainate receptors | 7.5e-01 | 8.8e-01 | 9.9e-01 | 9.6e-01 | 5.5e-01 | 3.3e-01 |
| 1176 | (REACTOME) Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) | 7.5e-01 | 1.7e-01 | 9.1e-01 | 8.5e-01 | 5.6e-01 | 3.4e-01 |
| 1177 | (REACTOME) Defective CP causes aceruloplasminemia (ACERULOP) | 7.5e-01 | 1.7e-01 | 9.1e-01 | 8.5e-01 | 5.6e-01 | 3.4e-01 |
| 1343 | (REACTOME) Highly sodium permeable postsynaptic acetylcholine nicotinic receptors | 7.5e-01 | 7.1e-01 | 9.5e-01 | 9.5e-01 | 7.7e-01 | 5.3e-01 |
| 227 | (REACTOME) Integration of provirus | 7.5e-01 | 8.1e-01 | 8.3e-01 | 9.4e-01 | 7.2e-01 | 6.9e-01 |
| 1370 | (REACTOME) TP53 Regulates Transcription of DNA Repair Genes | 7.5e-01 | 9.2e-01 | 6.0e-01 | 8.5e-01 | 6.7e-01 | 2.1e-01 |
| 1662 | (REACTOME) RAB GEFs exchange GTP for GDP on RABs | 7.5e-01 | 7.5e-01 | 6.0e-01 | 9.0e-01 | 4.7e-01 | 9.2e-01 |
| 1598 | (REACTOME) Regulation of IFNG signaling | 7.5e-01 | 3.4e-01 | 7.3e-01 | 9.4e-01 | 3.3e-01 | 7.9e-01 |
| 1512 | (REACTOME) Pyrimidine catabolism | 7.5e-01 | 9.6e-01 | 7.8e-01 | 8.5e-01 | 4.9e-01 | 8.4e-01 |
| 342 | (REACTOME) DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.5e-01 | 4.9e-01 | 8.2e-01 | 9.4e-01 | 2.8e-01 | 9.1e-01 |
| 136 | (REACTOME) Activation of BMF and translocation to mitochondria | 7.5e-01 | 5.8e-01 | 9.6e-01 | 9.5e-01 | 8.9e-01 | 8.5e-01 |
| 462 | (REACTOME) Pre-NOTCH Processing in the Endoplasmic Reticulum | 7.5e-01 | 5.1e-01 | 8.6e-01 | 9.7e-01 | 9.8e-01 | 8.9e-01 |
| 719 | (REACTOME) Activation of NIMA Kinases NEK9, NEK6, NEK7 | 7.5e-01 | 9.9e-01 | 9.7e-01 | 9.6e-01 | 7.7e-01 | 7.7e-01 |
| 822 | (REACTOME) Enzymatic degradation of dopamine by COMT | 7.5e-01 | 9.9e-01 | 8.2e-01 | 9.5e-01 | 9.1e-01 | 5.6e-01 |
| 1290 | (REACTOME) Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome | 7.5e-01 | 7.5e-01 | 9.7e-01 | 9.6e-01 | 7.6e-01 | 1.0e-01 |
| 1561 | (REACTOME) Platelet Adhesion to exposed collagen | 7.5e-01 | 9.8e-01 | 8.0e-01 | 9.0e-01 | 6.4e-01 | 5.0e-02 |
| 1941 | (REACTOME) Amino acids regulate mTORC1 | 7.5e-01 | 5.7e-01 | 6.3e-01 | 9.4e-01 | 9.1e-01 | 4.2e-01 |
| 2102 | (REACTOME) Sensory perception of salty taste | 7.5e-01 | 5.6e-01 | 6.3e-01 | 8.5e-01 | 6.7e-01 | 7.8e-01 |
| 2116 | (REACTOME) Expression and translocation of olfactory receptors | 7.5e-01 | 7.8e-01 | 9.0e-01 | 9.4e-01 | 5.4e-01 | 7.1e-01 |
| 2147 | (REACTOME) Amyloid fiber formation | 7.5e-01 | 8.1e-01 | 9.1e-01 | 8.1e-01 | 6.6e-01 | 5.1e-01 |
| 854 | (REACTOME) Beta-catenin independent WNT signaling | 7.5e-01 | 6.8e-01 | 8.7e-01 | 9.5e-01 | 8.5e-01 | 4.4e-01 |
| 224 | (REACTOME) HIV Life Cycle | 7.5e-01 | 8.0e-01 | 9.9e-01 | 9.4e-01 | 3.6e-01 | 8.0e-02 |
| 464 | (REACTOME) Pre-NOTCH Processing in Golgi | 7.5e-01 | 4.7e-01 | 8.3e-01 | 9.0e-01 | 6.4e-01 | 5.6e-01 |
| 704 | (REACTOME) EPH-Ephrin signaling | 7.5e-01 | 6.5e-01 | 8.9e-01 | 9.5e-01 | 8.2e-01 | 9.0e-02 |
| 788 | (REACTOME) Defective B3GAT3 causes JDSSDHD | 7.5e-01 | 9.8e-01 | 6.1e-01 | 9.6e-01 | 6.1e-01 | 1.1e-01 |
| 973 | (REACTOME) Transport of glycerol from adipocytes to the liver by Aquaporins | 7.5e-01 | 8.6e-01 | 9.1e-01 | 7.0e-01 | 8.5e-01 | 2.6e-01 |
| 1006 | (REACTOME) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | 7.5e-01 | 7.3e-01 | 8.5e-01 | 9.4e-01 | 5.8e-01 | 8.3e-01 |
| 1121 | (REACTOME) Synthesis of diphthamide-EEF2 | 7.5e-01 | 8.8e-01 | 9.2e-01 | 9.4e-01 | 7.1e-01 | 4.9e-01 |
| 1378 | (REACTOME) RAS signaling downstream of NF1 loss-of-function variants | 7.5e-01 | 8.8e-01 | 7.8e-01 | 9.5e-01 | 9.9e-01 | 8.0e-01 |
| 1495 | (REACTOME) mRNA Editing: C to U Conversion | 7.5e-01 | 1.0e+00 | 9.6e-01 | 9.0e-01 | 6.2e-01 | 6.8e-01 |
| 1541 | (REACTOME) Purine salvage | 7.5e-01 | 8.9e-01 | 6.0e-01 | 9.7e-01 | 6.8e-01 | 8.9e-01 |
| 1550 | (REACTOME) mRNA Editing | 7.5e-01 | 1.0e+00 | 9.6e-01 | 9.0e-01 | 6.2e-01 | 6.8e-01 |
| 1551 | (REACTOME) Formation of the Editosome | 7.5e-01 | 1.0e+00 | 9.6e-01 | 9.0e-01 | 6.2e-01 | 6.8e-01 |
| 1734 | (REACTOME) Chylomicron remodeling | 7.5e-01 | 3.4e-01 | 9.6e-01 | 6.9e-01 | 5.1e-01 | 6.2e-01 |
| 1791 | (REACTOME) RHOT2 GTPase cycle | 7.5e-01 | 2.6e-01 | 8.3e-01 | 9.7e-01 | 8.9e-01 | 9.8e-01 |
| 1865 | (REACTOME) Lewis blood group biosynthesis | 7.5e-01 | 9.1e-01 | 8.6e-01 | 7.8e-01 | 3.4e-01 | 4.3e-01 |
| 2099 | (REACTOME) Nuclear events stimulated by ALK signaling in cancer | 7.5e-01 | 3.8e-01 | 7.8e-01 | 8.2e-01 | 6.2e-01 | 1.0e+00 |
| 1481 | (REACTOME) Tryptophan catabolism | 7.6e-01 | 7.7e-01 | 9.2e-01 | 8.8e-01 | 3.8e-01 | 7.9e-01 |
| 264 | (REACTOME) Nef and signal transduction | 7.6e-01 | 4.7e-01 | 9.8e-01 | 8.5e-01 | 8.7e-01 | 2.9e-01 |
| 461 | (REACTOME) Gap junction degradation | 7.6e-01 | 8.1e-01 | 9.5e-01 | 1.0e+00 | 6.4e-01 | 8.4e-01 |
| 823 | (REACTOME) Enzymatic degradation of Dopamine by monoamine oxidase | 7.6e-01 | 9.9e-01 | 6.3e-01 | 9.5e-01 | 9.4e-01 | 6.1e-01 |
| 989 | (REACTOME) Defective B3GALT6 causes EDSP2 and SEMDJL1 | 7.6e-01 | 9.4e-01 | 6.1e-01 | 9.5e-01 | 4.9e-01 | 3.0e-02 |
| 1375 | (REACTOME) Signaling by high-kinase activity BRAF mutants | 7.6e-01 | 9.4e-01 | 9.1e-01 | 8.5e-01 | 8.7e-01 | 7.1e-01 |
| 1796 | (REACTOME) RHOT1 GTPase cycle | 7.6e-01 | 2.6e-01 | 8.2e-01 | 9.2e-01 | 9.9e-01 | 1.0e+00 |
| 1847 | (REACTOME) LXRs regulate gene expression linked to lipogenesis | 7.6e-01 | 5.5e-01 | 6.2e-01 | 8.5e-01 | 4.9e-01 | 4.3e-01 |
| 2013 | (REACTOME) Signaling by CSF3 (G-CSF) | 7.6e-01 | 8.0e-01 | 8.9e-01 | 8.5e-01 | 7.1e-01 | 8.6e-01 |
| 1708 | (REACTOME) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | 7.6e-01 | 5.2e-01 | 7.2e-01 | 9.0e-01 | 4.0e-01 | 5.3e-01 |
| 1971 | (REACTOME) Anti-inflammatory response favouring Leishmania parasite infection | 7.6e-01 | 3.8e-01 | 8.9e-01 | 9.0e-01 | 4.2e-01 | 2.4e-01 |
| 1979 | (REACTOME) Leishmania parasite growth and survival | 7.6e-01 | 3.8e-01 | 8.9e-01 | 9.0e-01 | 4.2e-01 | 2.4e-01 |
| 430 | (REACTOME) Synthesis of IP3 and IP4 in the cytosol | 7.6e-01 | 4.4e-01 | 9.3e-01 | 8.5e-01 | 2.8e-01 | 7.4e-01 |
| 713 | (REACTOME) POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 7.6e-01 | 4.4e-01 | 7.8e-01 | 7.8e-01 | 4.9e-01 | 4.4e-01 |
| 981 | (REACTOME) Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 7.6e-01 | 6.1e-01 | 9.0e-01 | 8.1e-01 | 5.7e-01 | 6.9e-01 |
| 51 | (REACTOME) Neurotransmitter receptors and postsynaptic signal transmission | 7.6e-01 | 1.0e+00 | 9.0e-01 | 1.0e+00 | 5.0e-01 | 7.1e-01 |
| 168 | (REACTOME) Acyl chain remodeling of DAG and TAG | 7.6e-01 | 1.6e-01 | 6.0e-01 | 7.8e-01 | 9.6e-01 | 4.3e-01 |
| 567 | (REACTOME) YAP1- and WWTR1 (TAZ)-stimulated gene expression | 7.6e-01 | 6.3e-01 | 9.6e-01 | 8.5e-01 | 8.6e-01 | 8.4e-01 |
| 1256 | (REACTOME) Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) | 7.6e-01 | 1.8e-01 | 9.5e-01 | 8.2e-01 | 5.6e-01 | 6.8e-01 |
| 232 | (REACTOME) Synthesis of glycosylphosphatidylinositol (GPI) | 7.6e-01 | 7.7e-01 | 6.0e-01 | 9.4e-01 | 6.1e-01 | 7.9e-01 |
| 493 | (REACTOME) VEGF ligand-receptor interactions | 7.6e-01 | 9.0e-01 | 8.5e-01 | 8.5e-01 | 4.2e-01 | 6.9e-01 |
| 498 | (REACTOME) VEGF binds to VEGFR leading to receptor dimerization | 7.6e-01 | 9.0e-01 | 8.5e-01 | 8.5e-01 | 4.2e-01 | 6.9e-01 |
| 1403 | (REACTOME) Bloch pathway | 7.6e-01 | 9.2e-01 | 6.2e-01 | 7.8e-01 | 8.7e-01 | 9.7e-01 |
| 1404 | (REACTOME) Kandutsch-Russell pathway | 7.6e-01 | 9.2e-01 | 6.2e-01 | 7.8e-01 | 8.7e-01 | 9.7e-01 |
| 1477 | (REACTOME) Branched-chain amino acid catabolism | 7.6e-01 | 7.0e-02 | 7.3e-01 | 7.8e-01 | 5.6e-01 | 3.0e-01 |
| 120 | (REACTOME) Voltage gated Potassium channels | 7.6e-01 | 8.4e-01 | 9.6e-01 | 9.1e-01 | 6.4e-01 | 3.8e-01 |
| 1595 | (REACTOME) The AIM2 inflammasome | 7.6e-01 | 4.3e-01 | 9.1e-01 | 8.9e-01 | 3.5e-01 | 4.3e-01 |
| 140 | (REACTOME) Extrinsic Pathway of Fibrin Clot Formation | 7.6e-01 | 9.4e-01 | 9.2e-01 | 9.4e-01 | 9.4e-01 | 6.0e-02 |
| 647 | (REACTOME) EGFR Transactivation by Gastrin | 7.6e-01 | 9.5e-01 | 8.7e-01 | 9.1e-01 | 5.7e-01 | 3.4e-01 |
| 787 | (REACTOME) Defective B4GALT7 causes EDS, progeroid type | 7.6e-01 | 9.6e-01 | 7.3e-01 | 9.6e-01 | 6.1e-01 | 3.0e-02 |
| 1777 | (REACTOME) Interleukin-18 signaling | 7.6e-01 | 8.5e-01 | 6.0e-01 | 9.9e-01 | 9.3e-01 | 3.7e-01 |
| 1395 | (REACTOME) Regulation of TP53 Activity through Association with Co-factors | 7.7e-01 | 9.0e-01 | 7.9e-01 | 9.4e-01 | 8.8e-01 | 3.0e-02 |
| 1846 | (REACTOME) Activated NTRK2 signals through FRS2 and FRS3 | 7.7e-01 | 9.1e-01 | 8.6e-01 | 9.4e-01 | 6.0e-01 | 6.8e-01 |
| 2085 | (REACTOME) Heme signaling | 7.7e-01 | 2.1e-01 | 9.2e-01 | 9.5e-01 | 8.6e-01 | 8.0e-01 |
| 419 | (REACTOME) STING mediated induction of host immune responses | 7.7e-01 | 4.5e-01 | 6.0e-01 | 9.1e-01 | 4.3e-01 | 9.2e-01 |
| 2021 | (REACTOME) Attachment and Entry_1 | 7.7e-01 | 8.3e-01 | 6.3e-01 | 9.7e-01 | 8.9e-01 | 5.9e-01 |
| 347 | (REACTOME) Adenylate cyclase activating pathway | 7.7e-01 | 1.6e-01 | 9.8e-01 | 9.1e-01 | 7.7e-01 | 8.9e-01 |
| 889 | (REACTOME) Rap1 signalling | 7.7e-01 | 9.9e-01 | 9.6e-01 | 8.5e-01 | 8.2e-01 | 4.6e-01 |
| 1102 | (REACTOME) Toxicity of tetanus toxin (tetX) | 7.7e-01 | 8.7e-01 | 9.6e-01 | 9.1e-01 | 8.4e-01 | 7.3e-01 |
| 250 | (REACTOME) PP2A-mediated dephosphorylation of key metabolic factors | 7.7e-01 | 6.7e-01 | 8.5e-01 | 8.7e-01 | 9.2e-01 | 8.1e-01 |
| 1655 | (REACTOME) CREB3 factors activate genes | 7.7e-01 | 4.3e-01 | 6.0e-01 | 8.5e-01 | 4.2e-01 | 5.6e-01 |
| 1282 | (REACTOME) MAP2K and MAPK activation | 7.7e-01 | 8.8e-01 | 9.1e-01 | 9.0e-01 | 8.7e-01 | 7.9e-01 |
| 864 | (REACTOME) Orexin and neuropeptides FF and QRFP bind to their respective receptors | 7.7e-01 | 4.5e-01 | 8.5e-01 | 9.4e-01 | 1.0e+00 | 5.7e-01 |
| 1794 | (REACTOME) RAC3 GTPase cycle | 7.7e-01 | 5.0e-02 | 8.6e-01 | 9.0e-01 | 3.8e-01 | 2.6e-01 |
| 59 | (REACTOME) Formation of the Early Elongation Complex | 7.7e-01 | 3.9e-01 | 9.8e-01 | 8.5e-01 | 2.7e-01 | 1.9e-01 |
| 294 | (REACTOME) Formation of the HIV-1 Early Elongation Complex | 7.7e-01 | 3.9e-01 | 9.8e-01 | 8.5e-01 | 2.7e-01 | 1.9e-01 |
| 749 | (REACTOME) Chromatin modifying enzymes | 7.7e-01 | 4.1e-01 | 6.0e-01 | 9.5e-01 | 9.8e-01 | 3.9e-01 |
| 1019 | (REACTOME) Neurofascin interactions | 7.7e-01 | 8.0e-01 | 9.6e-01 | 8.5e-01 | 5.2e-01 | 7.2e-01 |
| 1062 | (REACTOME) Chromatin organization | 7.7e-01 | 4.1e-01 | 6.0e-01 | 9.5e-01 | 9.8e-01 | 3.9e-01 |
| 1677 | (REACTOME) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | 7.7e-01 | 6.5e-01 | 8.6e-01 | 1.0e+00 | 7.9e-01 | 8.5e-01 |
| 42 | (REACTOME) G-protein mediated events | 7.8e-01 | 6.3e-01 | 9.9e-01 | 9.4e-01 | 8.9e-01 | 4.3e-01 |
| 1297 | (REACTOME) Defective ABCC8 can cause hypo- and hyper-glycemias | 7.8e-01 | 8.2e-01 | 6.4e-01 | 9.4e-01 | 6.0e-01 | 6.0e-02 |
| 23 | (REACTOME) Activation and oligomerization of BAK protein | 7.8e-01 | 6.3e-01 | 8.5e-01 | 9.4e-01 | 9.6e-01 | 5.7e-01 |
| 117 | (REACTOME) Inwardly rectifying K+ channels | 7.8e-01 | 9.9e-01 | 6.0e-01 | 9.1e-01 | 4.2e-01 | 5.0e-01 |
| 121 | (REACTOME) Tandem pore domain potassium channels | 7.8e-01 | 9.0e-01 | 8.5e-01 | 9.9e-01 | 6.7e-01 | 3.3e-01 |
| 122 | (REACTOME) TWIK-releated acid-sensitive K+ channel (TASK) | 7.8e-01 | 9.0e-01 | 8.5e-01 | 9.9e-01 | 6.7e-01 | 3.3e-01 |
| 209 | (REACTOME) Transport of Mature mRNA derived from an Intron-Containing Transcript | 7.8e-01 | 8.8e-01 | 7.3e-01 | 8.3e-01 | 2.2e-01 | 3.3e-01 |
| 214 | (REACTOME) Removal of aminoterminal propeptides from gamma-carboxylated proteins | 7.8e-01 | 9.2e-01 | 9.9e-01 | 9.3e-01 | 6.5e-01 | 8.7e-01 |
| 331 | (REACTOME) Inhibition of Host mRNA Processing and RNA Silencing | 7.8e-01 | 8.2e-01 | 9.6e-01 | 1.0e+00 | 7.6e-01 | 4.7e-01 |
| 517 | (REACTOME) A tetrasaccharide linker sequence is required for GAG synthesis | 7.8e-01 | 1.0e+00 | 7.5e-01 | 9.6e-01 | 8.7e-01 | 1.1e-01 |
| 563 | (REACTOME) Fcgamma receptor (FCGR) dependent phagocytosis | 7.8e-01 | 6.8e-01 | 9.5e-01 | 9.4e-01 | 6.1e-01 | 5.0e-02 |
| 624 | (REACTOME) Synthesis of Lipoxins (LX) | 7.8e-01 | 9.1e-01 | 9.4e-01 | 8.5e-01 | 3.0e-01 | 6.9e-01 |
| 640 | (REACTOME) Binding and Uptake of Ligands by Scavenger Receptors | 7.8e-01 | 9.8e-01 | 8.7e-01 | 9.4e-01 | 6.9e-01 | 9.0e-02 |
| 710 | (REACTOME) FCERI mediated Ca+2 mobilization | 7.8e-01 | 4.1e-01 | 8.3e-01 | 1.0e+00 | 2.7e-01 | 2.1e-01 |
| 734 | (REACTOME) SUMOylation of DNA damage response and repair proteins | 7.8e-01 | 6.4e-01 | 6.0e-01 | 1.0e+00 | 9.2e-01 | 5.7e-01 |
| 789 | (REACTOME) Defective CHST3 causes SEDCJD | 7.8e-01 | 6.8e-01 | 9.0e-01 | 9.4e-01 | 6.5e-01 | 5.3e-01 |
| 824 | (REACTOME) Clearance of dopamine | 7.8e-01 | 1.0e+00 | 8.2e-01 | 9.5e-01 | 9.1e-01 | 5.6e-01 |
| 1060 | (REACTOME) Defective DHDDS causes RP59 | 7.8e-01 | 7.5e-01 | 9.8e-01 | 7.8e-01 | 3.5e-01 | 9.8e-01 |
| 1081 | (REACTOME) Interleukin-3, Interleukin-5 and GM-CSF signaling | 7.8e-01 | 8.1e-01 | 9.1e-01 | 9.4e-01 | 4.0e-01 | 2.4e-01 |
| 1097 | (REACTOME) Toxicity of botulinum toxin type D (botD) | 7.8e-01 | 9.6e-01 | 9.6e-01 | 9.5e-01 | 6.9e-01 | 9.3e-01 |
| 1101 | (REACTOME) Toxicity of botulinum toxin type F (botF) | 7.8e-01 | 9.6e-01 | 9.6e-01 | 9.5e-01 | 6.9e-01 | 9.3e-01 |
| 1105 | (REACTOME) Myogenesis | 7.8e-01 | 6.3e-01 | 9.6e-01 | 9.9e-01 | 4.9e-01 | 7.6e-01 |
| 1132 | (REACTOME) RA biosynthesis pathway | 7.8e-01 | 9.0e-01 | 9.4e-01 | 9.4e-01 | 9.1e-01 | 8.3e-01 |
| 1323 | (REACTOME) HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.8e-01 | 8.7e-01 | 6.0e-01 | 7.8e-01 | 3.9e-01 | 4.2e-01 |
| 1326 | (REACTOME) Homologous DNA Pairing and Strand Exchange | 7.8e-01 | 6.1e-01 | 5.2e-01 | 7.8e-01 | 3.6e-01 | 1.0e+00 |
| 1328 | (REACTOME) Processing of DNA double-strand break ends | 7.8e-01 | 8.1e-01 | 6.0e-01 | 9.4e-01 | 9.1e-01 | 3.3e-01 |
| 1425 | (REACTOME) cell division | 7.8e-01 | 4.5e-01 | 1.0e+00 | 9.8e-01 | 9.4e-01 | 3.2e-01 |
| 1440 | (REACTOME) Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes | 7.8e-01 | 1.6e-01 | 9.2e-01 | 9.1e-01 | 8.1e-01 | 3.3e-01 |
| 1493 | (REACTOME) mRNA Splicing | 7.8e-01 | 1.8e-01 | 6.0e-01 | 7.8e-01 | 1.0e-02 | 5.0e-02 |
| 1750 | (REACTOME) RHOA GTPase cycle | 7.8e-01 | 4.0e-02 | 8.9e-01 | 8.5e-01 | 5.4e-01 | 1.7e-01 |
| 1803 | (REACTOME) TICAM1-dependent activation of IRF3/IRF7 | 7.8e-01 | 6.0e-01 | 7.1e-01 | 3.4e-01 | 2.2e-01 | 4.9e-01 |
| 1974 | (REACTOME) Parasite infection | 7.8e-01 | 8.2e-01 | 7.3e-01 | 9.2e-01 | 8.9e-01 | 1.4e-01 |
| 1975 | (REACTOME) Leishmania phagocytosis | 7.8e-01 | 8.2e-01 | 7.3e-01 | 9.2e-01 | 8.9e-01 | 1.4e-01 |
| 1977 | (REACTOME) FCGR3A-mediated phagocytosis | 7.8e-01 | 8.2e-01 | 7.3e-01 | 9.2e-01 | 8.9e-01 | 1.4e-01 |
| 2026 | (REACTOME) SARS-CoV-1 Genome Replication and Transcription | 7.8e-01 | 4.4e-01 | 9.4e-01 | 9.4e-01 | 6.0e-01 | 9.6e-01 |
| 2028 | (REACTOME) Replication of the SARS-CoV-1 genome | 7.8e-01 | 4.4e-01 | 9.4e-01 | 9.4e-01 | 6.0e-01 | 9.6e-01 |
| 2056 | (REACTOME) SARS-CoV-2 Genome Replication and Transcription | 7.8e-01 | 4.4e-01 | 9.4e-01 | 9.4e-01 | 6.0e-01 | 9.6e-01 |
| 2057 | (REACTOME) Replication of the SARS-CoV-2 genome | 7.8e-01 | 4.4e-01 | 9.4e-01 | 9.4e-01 | 6.0e-01 | 9.6e-01 |
| 591 | (REACTOME) Peptide hormone biosynthesis | 7.8e-01 | 9.2e-01 | 9.1e-01 | 8.5e-01 | 6.3e-01 | 7.9e-01 |
| 1937 | (REACTOME) Manipulation of host energy metabolism | 7.8e-01 | 9.4e-01 | 6.2e-01 | 9.2e-01 | 9.8e-01 | 5.1e-01 |
| 1191 | (REACTOME) Dectin-2 family | 7.8e-01 | 9.5e-01 | 6.4e-01 | 9.4e-01 | 8.9e-01 | 1.1e-01 |
| 1241 | (REACTOME) Downstream signaling of activated FGFR4 | 7.8e-01 | 8.0e-01 | 1.0e+00 | 9.5e-01 | 5.2e-01 | 4.0e-01 |
| 1688 | (REACTOME) RUNX2 regulates osteoblast differentiation | 7.8e-01 | 6.3e-01 | 1.0e+00 | 9.1e-01 | 6.7e-01 | 7.9e-01 |
| 1712 | (REACTOME) RUNX3 regulates RUNX1-mediated transcription | 7.8e-01 | 5.9e-01 | NA | 9.6e-01 | 9.2e-01 | 2.6e-01 |
| 1 | (REACTOME) Interleukin-6 signaling | 7.8e-01 | 7.4e-01 | 8.3e-01 | 9.1e-01 | 7.2e-01 | 7.0e-01 |
| 353 | (REACTOME) p38MAPK events | 7.8e-01 | 6.7e-01 | 9.1e-01 | 9.4e-01 | 2.4e-01 | 2.8e-01 |
| 1733 | (REACTOME) Plasma lipoprotein remodeling | 7.8e-01 | 5.3e-01 | 9.1e-01 | 9.1e-01 | 3.2e-01 | 6.6e-01 |
| 1319 | (REACTOME) Homology Directed Repair | 7.8e-01 | 8.1e-01 | 5.6e-01 | 4.2e-01 | 3.7e-01 | 3.4e-01 |
| 776 | (REACTOME) Notch-HLH transcription pathway | 7.8e-01 | 5.6e-01 | 6.0e-01 | 9.4e-01 | 6.1e-01 | 1.0e+00 |
| 720 | (REACTOME) SUMOylation | 7.8e-01 | 9.2e-01 | 8.7e-01 | 9.2e-01 | 3.2e-01 | 8.0e-01 |
| 1749 | (REACTOME) Triglyceride metabolism | 7.8e-01 | 9.1e-01 | 8.8e-01 | 9.6e-01 | 8.0e-01 | 5.5e-01 |
| 1369 | (REACTOME) Protein-protein interactions at synapses | 7.9e-01 | 9.2e-01 | 7.9e-01 | 9.2e-01 | 5.3e-01 | 8.9e-01 |
| 1525 | (REACTOME) Base Excision Repair | 7.9e-01 | 1.7e-01 | 7.3e-01 | 9.0e-01 | 7.5e-01 | 4.1e-01 |
| 1967 | (REACTOME) Defective factor VIII causes hemophilia A | 7.9e-01 | 9.3e-01 | 9.7e-01 | 9.4e-01 | 8.4e-01 | 2.6e-01 |
| 1719 | (REACTOME) Nucleotide catabolism | 7.9e-01 | 4.4e-01 | 8.6e-01 | 9.4e-01 | 6.1e-01 | 9.1e-01 |
| 66 | (REACTOME) Disinhibition of SNARE formation | 7.9e-01 | 8.0e-01 | 7.3e-01 | 9.9e-01 | 9.6e-01 | 7.7e-01 |
| 590 | (REACTOME) Serotonin and melatonin biosynthesis | 7.9e-01 | 8.1e-01 | 8.5e-01 | 8.5e-01 | 1.4e-01 | 7.3e-01 |
| 1745 | (REACTOME) Lipid particle organization | 7.9e-01 | NA | 7.6e-01 | 8.5e-01 | 3.5e-01 | 8.0e-01 |
| 497 | (REACTOME) RHO GTPase Effectors | 7.9e-01 | 9.9e-01 | 9.1e-01 | 9.9e-01 | 8.4e-01 | 2.2e-01 |
| 1011 | (REACTOME) Synthesis of substrates in N-glycan biosythesis | 7.9e-01 | 8.6e-01 | 9.8e-01 | 9.4e-01 | 8.0e-01 | 8.6e-01 |
| 1469 | (REACTOME) Glycogen breakdown (glycogenolysis) | 7.9e-01 | 7.2e-01 | 6.0e-01 | 8.5e-01 | 6.6e-01 | 2.0e-02 |
| 1771 | (REACTOME) Interleukin-37 signaling | 7.9e-01 | 8.1e-01 | 8.5e-01 | 9.1e-01 | 8.4e-01 | 4.2e-01 |
| 63 | (REACTOME) Activation, translocation and oligomerization of BAX | 7.9e-01 | 3.7e-01 | 9.6e-01 | 9.9e-01 | 8.7e-01 | 7.4e-01 |
| 12 | (REACTOME) Recognition and association of DNA glycosylase with site containing an affected pyrimidine | 7.9e-01 | 3.3e-01 | 8.3e-01 | 9.9e-01 | 7.2e-01 | 6.9e-01 |
| 13 | (REACTOME) Cleavage of the damaged pyrimidine | 7.9e-01 | 3.3e-01 | 8.3e-01 | 9.9e-01 | 7.2e-01 | 6.9e-01 |
| 14 | (REACTOME) Recognition and association of DNA glycosylase with site containing an affected purine | 7.9e-01 | 3.3e-01 | 8.3e-01 | 9.9e-01 | 7.2e-01 | 6.9e-01 |
| 15 | (REACTOME) Cleavage of the damaged purine | 7.9e-01 | 3.3e-01 | 8.3e-01 | 9.9e-01 | 7.2e-01 | 6.9e-01 |
| 174 | (REACTOME) Synthesis of PA | 7.9e-01 | 1.6e-01 | 8.3e-01 | 8.5e-01 | 8.4e-01 | 6.8e-01 |
| 268 | (REACTOME) Activation of PKB | 7.9e-01 | 9.1e-01 | 9.6e-01 | 9.2e-01 | 6.9e-01 | 6.8e-01 |
| 359 | (REACTOME) Classical antibody-mediated complement activation | 7.9e-01 | 3.3e-01 | 9.8e-01 | 8.6e-01 | 5.6e-01 | 6.3e-01 |
| 387 | (REACTOME) Phosphorylation of the APC/C | 7.9e-01 | 3.9e-01 | 9.4e-01 | 1.0e+00 | 6.5e-01 | 2.5e-01 |
| 1139 | (REACTOME) Aflatoxin activation and detoxification | 7.9e-01 | 5.6e-01 | 1.0e+00 | 9.6e-01 | 5.8e-01 | 8.9e-01 |
| 1530 | (REACTOME) Depurination | 7.9e-01 | 3.3e-01 | 8.3e-01 | 9.9e-01 | 7.2e-01 | 6.9e-01 |
| 1531 | (REACTOME) Depyrimidination | 7.9e-01 | 3.3e-01 | 8.3e-01 | 9.9e-01 | 7.2e-01 | 6.9e-01 |
| 1532 | (REACTOME) Base-Excision Repair, AP Site Formation | 7.9e-01 | 3.3e-01 | 8.3e-01 | 9.9e-01 | 7.2e-01 | 6.9e-01 |
| 1828 | (REACTOME) MECP2 regulates transcription of neuronal ligands | 7.9e-01 | 5.4e-01 | 9.0e-01 | 9.6e-01 | 8.1e-01 | 3.4e-01 |
| 1894 | (REACTOME) Class I peroxisomal membrane protein import | 7.9e-01 | 8.0e-01 | 8.3e-01 | 7.8e-01 | 7.0e-01 | 6.9e-01 |
| 2012 | (REACTOME) Defective F8 sulfation at Y1699 | 7.9e-01 | 1.0e+00 | 1.0e+00 | 9.4e-01 | 7.2e-01 | 4.2e-01 |
| 2134 | (REACTOME) Epithelial-Mesenchymal Transition (EMT) during gastrulation | 7.9e-01 | 9.5e-01 | 6.0e-01 | 9.0e-01 | 7.5e-01 | 6.6e-01 |
| 489 | (REACTOME) Glucocorticoid biosynthesis | 7.9e-01 | 5.8e-01 | 6.0e-01 | 7.8e-01 | 3.7e-01 | 8.0e-01 |
| 287 | (REACTOME) Initial triggering of complement | 7.9e-01 | 4.4e-01 | 9.2e-01 | 8.5e-01 | 7.2e-01 | 5.6e-01 |
| 1496 | (REACTOME) Transport of Mature Transcript to Cytoplasm | 7.9e-01 | 8.7e-01 | 6.6e-01 | 8.3e-01 | 2.3e-01 | 1.8e-01 |
| 118 | (REACTOME) Potassium transport channels | 8.0e-01 | 8.6e-01 | 9.7e-01 | NA | 8.7e-01 | NA |
| 153 | (REACTOME) Collagen degradation | 8.0e-01 | 4.7e-01 | 6.0e-01 | 9.3e-01 | 5.9e-01 | 4.4e-01 |
| 201 | (REACTOME) Telomere Maintenance | 8.0e-01 | 4.0e-01 | 6.0e-01 | 8.5e-01 | 6.3e-01 | 5.0e-01 |
| 203 | (REACTOME) Nucleotide metabolism | 8.0e-01 | 3.7e-01 | 7.6e-01 | 9.1e-01 | 7.1e-01 | 9.1e-01 |
| 456 | (REACTOME) FGFR2c ligand binding and activation | 8.0e-01 | 8.1e-01 | 9.7e-01 | 8.5e-01 | 8.4e-01 | 7.5e-01 |
| 490 | (REACTOME) Bile acid and bile salt metabolism | 8.0e-01 | 7.5e-01 | 6.0e-01 | 3.0e-01 | 7.3e-01 | 7.0e-01 |
| 576 | (REACTOME) alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 8.0e-01 | 9.5e-01 | 7.9e-01 | 9.4e-01 | 9.4e-01 | 6.0e-02 |
| 578 | (REACTOME) alpha-linolenic acid (ALA) metabolism | 8.0e-01 | 9.5e-01 | 7.9e-01 | 9.4e-01 | 9.4e-01 | 6.0e-02 |
| 785 | (REACTOME) GRB2:SOS provides linkage to MAPK signaling for Integrins | 8.0e-01 | 8.1e-01 | 8.5e-01 | 9.9e-01 | 8.5e-01 | 5.6e-01 |
| 816 | (REACTOME) Signaling by ROBO receptors | 8.0e-01 | 0.0e+00 | 7.3e-01 | 1.0e+00 | 2.2e-01 | 2.5e-01 |
| 1074 | (REACTOME) Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 | 8.0e-01 | 9.1e-01 | 8.7e-01 | 8.5e-01 | 8.7e-01 | 8.9e-01 |
| 1077 | (REACTOME) Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 | 8.0e-01 | 9.1e-01 | 8.7e-01 | 8.5e-01 | 8.7e-01 | 8.9e-01 |
| 1339 | (REACTOME) Respiratory electron transport | 8.0e-01 | 2.0e-02 | 8.4e-01 | 9.2e-01 | 1.9e-01 | 2.0e-02 |
| 1762 | (REACTOME) Signaling by NTRK2 (TRKB) | 8.0e-01 | 8.0e-01 | 9.9e-01 | 9.6e-01 | 7.8e-01 | 7.1e-01 |
| 2145 | (REACTOME) NPAS4 regulates expression of target genes | 8.0e-01 | 4.4e-01 | 6.8e-01 | 9.4e-01 | 8.9e-01 | 3.7e-01 |
| 1218 | (REACTOME) APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway | 8.0e-01 | 7.8e-01 | 8.3e-01 | 9.2e-01 | 8.3e-01 | 4.1e-01 |
| 2111 | (REACTOME) TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 8.0e-01 | 9.3e-01 | 8.7e-01 | 9.9e-01 | 8.3e-01 | 9.4e-01 |
| 1426 | (REACTOME) M Phase | 8.0e-01 | 5.6e-01 | 9.2e-01 | 1.0e+00 | 6.1e-01 | 4.0e-02 |
| 545 | (REACTOME) Metabolism of Angiotensinogen to Angiotensins | 8.0e-01 | 9.6e-01 | 9.7e-01 | 9.1e-01 | 4.7e-01 | 1.0e-02 |
| 751 | (REACTOME) IRF3-mediated induction of type I IFN | 8.0e-01 | 6.2e-01 | 6.0e-01 | 9.3e-01 | 6.0e-01 | 7.4e-01 |
| 1180 | (REACTOME) SLC transporter disorders | 8.0e-01 | 5.4e-01 | 6.3e-01 | 9.9e-01 | 4.0e-01 | 6.6e-01 |
| 1693 | (REACTOME) RUNX2 regulates genes involved in differentiation of myeloid cells | 8.0e-01 | 8.1e-01 | 8.5e-01 | 9.9e-01 | 6.1e-01 | 9.2e-01 |
| 355 | (REACTOME) Packaging Of Telomere Ends | 8.0e-01 | 3.3e-01 | 8.3e-01 | 9.9e-01 | 7.2e-01 | 6.9e-01 |
| 548 | (REACTOME) Chondroitin sulfate biosynthesis | 8.0e-01 | 9.4e-01 | 6.2e-01 | 9.6e-01 | 3.8e-01 | 1.2e-01 |
| 1407 | (REACTOME) COPI-mediated anterograde transport | 8.0e-01 | 5.8e-01 | 7.6e-01 | 9.4e-01 | 6.1e-01 | 3.4e-01 |
| 1453 | (REACTOME) G2/M DNA damage checkpoint | 8.0e-01 | 9.1e-01 | 6.0e-01 | 9.0e-01 | 7.7e-01 | 7.8e-01 |
| 1692 | (REACTOME) RUNX2 regulates genes involved in cell migration | 8.0e-01 | 7.4e-01 | 6.0e-01 | 8.5e-01 | 7.8e-01 | 6.4e-01 |
| 1723 | (REACTOME) Metabolism of steroids | 8.0e-01 | 7.0e-01 | 6.0e-01 | 7.8e-01 | 9.0e-01 | 6.6e-01 |
| 1776 | (REACTOME) ROBO receptors bind AKAP5 | 8.0e-01 | 1.0e+00 | 9.0e-01 | 8.5e-01 | 8.8e-01 | 8.7e-01 |
| 532 | (REACTOME) CREB phosphorylation | 8.0e-01 | 7.5e-01 | 7.6e-01 | 9.4e-01 | 9.2e-01 | 8.9e-01 |
| 394 | (REACTOME) Retrograde neurotrophin signalling | 8.0e-01 | 4.5e-01 | 1.0e+00 | 9.8e-01 | 9.3e-01 | 9.1e-01 |
| 933 | (REACTOME) Ligand-independent caspase activation via DCC | 8.0e-01 | 8.0e-01 | 8.5e-01 | 9.2e-01 | 8.7e-01 | 4.7e-01 |
| 1304 | (REACTOME) HDR through Homologous Recombination (HRR) | 8.0e-01 | 7.3e-01 | 5.2e-01 | 3.0e-01 | 2.7e-01 | 5.9e-01 |
| 569 | (REACTOME) Activated point mutants of FGFR2 | 8.0e-01 | 8.1e-01 | 9.7e-01 | 8.5e-01 | 6.4e-01 | 7.9e-01 |
| 1169 | (REACTOME) Diseases associated with glycosylation precursor biosynthesis | 8.0e-01 | 8.1e-01 | 9.9e-01 | 5.1e-01 | 3.5e-01 | 7.4e-01 |
| 2074 | (REACTOME) Inactivation of CSF3 (G-CSF) signaling | 8.1e-01 | 8.1e-01 | 8.5e-01 | 8.5e-01 | 7.8e-01 | 8.7e-01 |
| 2094 | (REACTOME) Miro GTPase Cycle | 8.1e-01 | 1.1e-01 | 8.3e-01 | 9.8e-01 | 9.5e-01 | 1.0e+00 |
| 978 | (REACTOME) Proton-coupled monocarboxylate transport | 8.1e-01 | 7.3e-01 | 7.6e-01 | 1.0e+00 | 4.7e-01 | 8.6e-01 |
| 1689 | (REACTOME) Invadopodia formation | 8.1e-01 | 8.8e-01 | 1.0e+00 | 9.1e-01 | 3.3e-01 | 3.0e-01 |
| 580 | (REACTOME) Cell death signalling via NRAGE, NRIF and NADE | 8.1e-01 | 6.1e-01 | 8.7e-01 | 8.1e-01 | 6.1e-01 | 7.1e-01 |
| 1178 | (REACTOME) Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 8.1e-01 | 9.7e-01 | 7.3e-01 | 9.5e-01 | 2.7e-01 | 1.7e-01 |
| 17 | (REACTOME) Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 8.1e-01 | 4.1e-01 | 6.0e-01 | 9.0e-01 | 7.7e-01 | 4.7e-01 |
| 61 | (REACTOME) E2F-enabled inhibition of pre-replication complex formation | 8.1e-01 | 5.6e-01 | 6.0e-01 | 8.5e-01 | 5.2e-01 | 9.8e-01 |
| 269 | (REACTOME) MTOR signalling | 8.1e-01 | 7.4e-01 | 8.3e-01 | 9.1e-01 | 7.9e-01 | 7.0e-02 |
| 518 | (REACTOME) Nicotinamide salvaging | 8.1e-01 | 5.9e-01 | 6.4e-01 | 7.8e-01 | 5.5e-01 | 4.5e-01 |
| 797 | (REACTOME) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | 8.1e-01 | 4.7e-01 | 9.9e-01 | 9.5e-01 | 6.9e-01 | 8.0e-02 |
| 1363 | (REACTOME) IL-6-type cytokine receptor ligand interactions | 8.1e-01 | 9.2e-01 | 8.1e-01 | 9.5e-01 | 7.8e-01 | 7.4e-01 |
| 2158 | (REACTOME) Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 8.1e-01 | 1.0e+00 | 7.2e-01 | 8.7e-01 | 6.9e-01 | 5.6e-01 |
| 2108 | (REACTOME) Drug ADME | 8.1e-01 | 7.8e-01 | 9.9e-01 | 3.9e-01 | 4.5e-01 | 3.7e-01 |
| 1114 | (REACTOME) Caspase activation via extrinsic apoptotic signalling pathway | 8.1e-01 | 6.1e-01 | 9.1e-01 | 8.5e-01 | 6.6e-01 | 7.2e-01 |
| 134 | (REACTOME) ABC transporters in lipid homeostasis | 8.1e-01 | 4.3e-01 | 7.3e-01 | 8.5e-01 | 7.5e-01 | 9.6e-01 |
| 35 | (REACTOME) PKA-mediated phosphorylation of CREB | 8.2e-01 | 9.9e-01 | 9.3e-01 | 9.4e-01 | 8.6e-01 | 4.4e-01 |
| 709 | (REACTOME) FCERI mediated MAPK activation | 8.2e-01 | 3.6e-01 | 6.2e-01 | 9.6e-01 | 7.9e-01 | 3.9e-01 |
| 1706 | (REACTOME) Cristae formation | 8.2e-01 | 3.6e-01 | 6.0e-01 | 8.4e-01 | 4.0e-01 | 8.1e-01 |
| 971 | (REACTOME) mRNA decay by 5’ to 3’ exoribonuclease | 8.2e-01 | 5.4e-01 | 9.1e-01 | 1.0e+00 | 8.7e-01 | 7.4e-01 |
| 817 | (REACTOME) Deactivation of the beta-catenin transactivating complex | 8.2e-01 | 6.3e-01 | 9.0e-01 | 8.0e-01 | 6.7e-01 | 6.5e-01 |
| 1188 | (REACTOME) BBSome-mediated cargo-targeting to cilium | 8.2e-01 | 4.8e-01 | 6.0e-01 | 9.5e-01 | 9.2e-01 | 8.9e-01 |
| 508 | (REACTOME) Biotin transport and metabolism | 8.2e-01 | 6.3e-01 | 9.2e-01 | 1.0e+00 | 9.2e-01 | 5.6e-01 |
| 87 | (REACTOME) Regulation of gene expression by Hypoxia-inducible Factor | 8.2e-01 | 6.8e-01 | 9.6e-01 | 9.2e-01 | 3.6e-01 | 6.6e-01 |
| 1387 | (REACTOME) Ion influx/efflux at host-pathogen interface | 8.2e-01 | 8.4e-01 | 9.0e-01 | 9.4e-01 | 7.2e-01 | 9.0e-01 |
| 1578 | (REACTOME) Beta oxidation of myristoyl-CoA to lauroyl-CoA | 8.2e-01 | 5.9e-01 | 8.3e-01 | 8.5e-01 | 4.0e-01 | 4.2e-01 |
| 2064 | (REACTOME) Signaling by ALK in cancer | 8.2e-01 | 7.2e-01 | 8.5e-01 | 7.9e-01 | 2.5e-01 | 9.4e-01 |
| 2098 | (REACTOME) Signaling by ALK fusions and activated point mutants | 8.2e-01 | 7.2e-01 | 8.5e-01 | 7.9e-01 | 2.5e-01 | 9.4e-01 |
| 1583 | (REACTOME) Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 8.2e-01 | 4.1e-01 | 8.5e-01 | 9.0e-01 | 5.6e-01 | 5.8e-01 |
| 2133 | (REACTOME) Transport of RCbl within the body | 8.2e-01 | 6.4e-01 | 8.9e-01 | 9.5e-01 | 8.7e-01 | 9.7e-01 |
| 724 | (REACTOME) Syndecan interactions | 8.2e-01 | 7.3e-01 | 7.8e-01 | 9.7e-01 | 3.4e-01 | 1.1e-01 |
| 282 | (REACTOME) mTORC1-mediated signalling | 8.2e-01 | 6.3e-01 | 9.2e-01 | 8.9e-01 | 5.9e-01 | 2.8e-01 |
| 1563 | (REACTOME) Plasmalogen biosynthesis | 8.2e-01 | 7.4e-01 | 6.4e-01 | 8.6e-01 | 7.9e-01 | 7.9e-01 |
| 803 | (REACTOME) p130Cas linkage to MAPK signaling for integrins | 8.2e-01 | 8.1e-01 | 6.0e-01 | 8.5e-01 | 7.8e-01 | 9.4e-01 |
| 202 | (REACTOME) Gap junction trafficking and regulation | 8.2e-01 | 8.2e-01 | 9.0e-01 | 1.0e+00 | 9.1e-01 | 7.4e-01 |
| 634 | (REACTOME) Abacavir transmembrane transport | 8.2e-01 | 6.8e-01 | 1.0e+00 | 1.0e+00 | 8.9e-01 | 5.5e-01 |
| 1582 | (REACTOME) Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 8.2e-01 | 6.1e-01 | 8.3e-01 | 8.5e-01 | 8.3e-01 | 7.9e-01 |
| 1610 | (REACTOME) PTK6 Regulates Cell Cycle | 8.2e-01 | 1.1e-01 | 9.4e-01 | 9.4e-01 | 4.3e-01 | 3.1e-01 |
| 1711 | (REACTOME) RUNX3 regulates YAP1-mediated transcription | 8.2e-01 | 8.8e-01 | 7.3e-01 | 9.7e-01 | 7.8e-01 | 8.2e-01 |
| 1882 | (REACTOME) Negative regulators of RIG-I/MDA5 signaling | 8.2e-01 | 3.8e-01 | 6.1e-01 | 9.5e-01 | 2.7e-01 | 9.2e-01 |
| 1899 | (REACTOME) HCMV Infection | 8.2e-01 | 9.6e-01 | 8.6e-01 | 9.7e-01 | 7.6e-01 | 1.2e-01 |
| 1932 | (REACTOME) Inhibition of membrane repair | 8.2e-01 | 8.3e-01 | 7.3e-01 | 9.8e-01 | 8.5e-01 | 3.6e-01 |
| 114 | (REACTOME) Activation of G protein gated Potassium channels | 8.2e-01 | 9.1e-01 | 9.4e-01 | 9.4e-01 | 8.9e-01 | 8.8e-01 |
| 116 | (REACTOME) G protein gated Potassium channels | 8.2e-01 | 9.1e-01 | 9.4e-01 | 9.4e-01 | 8.9e-01 | 8.8e-01 |
| 139 | (REACTOME) Ligand-dependent caspase activation | 8.2e-01 | 2.6e-01 | 7.9e-01 | 8.6e-01 | 6.5e-01 | 2.4e-01 |
| 1581 | (REACTOME) Mitochondrial Fatty Acid Beta-Oxidation | 8.2e-01 | 4.7e-01 | 9.7e-01 | 9.3e-01 | 6.9e-01 | 1.0e+00 |
| 2165 | (REACTOME) Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 8.2e-01 | 9.1e-01 | 9.4e-01 | 9.4e-01 | 8.9e-01 | 8.8e-01 |
| 645 | (REACTOME) Downregulation of SMAD2/3:SMAD4 transcriptional activity | 8.2e-01 | 7.6e-01 | 8.5e-01 | 8.5e-01 | 8.3e-01 | 5.6e-01 |
| 324 | (REACTOME) Entry of Influenza Virion into Host Cell via Endocytosis | 8.2e-01 | 4.6e-01 | 8.7e-01 | 9.1e-01 | 8.5e-01 | 6.6e-01 |
| 1195 | (REACTOME) ARL13B-mediated ciliary trafficking of INPP5E | 8.2e-01 | 9.7e-01 | 8.7e-01 | 9.5e-01 | 5.1e-01 | 3.8e-01 |
| 1207 | (REACTOME) Hedgehog ‘on’ state | 8.3e-01 | 8.1e-01 | 8.7e-01 | 1.0e+00 | 3.4e-01 | 3.7e-01 |
| 200 | (REACTOME) Signaling by NOTCH | 8.3e-01 | 5.6e-01 | 9.1e-01 | 3.5e-01 | 6.5e-01 | 6.8e-01 |
| 1225 | (REACTOME) Phospholipase C-mediated cascade; FGFR2 | 8.3e-01 | 8.1e-01 | 9.4e-01 | 8.6e-01 | 5.4e-01 | 8.6e-01 |
| 1391 | (REACTOME) Regulation of TP53 Expression | 8.3e-01 | 9.9e-01 | 7.8e-01 | 9.4e-01 | 8.3e-01 | 3.3e-01 |
| 76 | (REACTOME) Fertilization | 8.3e-01 | 8.8e-01 | 9.4e-01 | 7.8e-01 | 6.1e-01 | 3.0e-01 |
| 1527 | (REACTOME) Death Receptor Signalling | 8.3e-01 | 8.1e-01 | 8.2e-01 | 8.5e-01 | 6.9e-01 | 9.1e-01 |
| 323 | (REACTOME) Export of Viral Ribonucleoproteins from Nucleus | 8.3e-01 | 7.2e-01 | 9.6e-01 | 9.8e-01 | 8.5e-01 | 4.2e-01 |
| 335 | (REACTOME) NEP/NS2 Interacts with the Cellular Export Machinery | 8.3e-01 | 8.1e-01 | 9.5e-01 | 9.8e-01 | 8.3e-01 | 3.4e-01 |
| 384 | (REACTOME) Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 8.3e-01 | 3.8e-01 | 9.0e-01 | 9.9e-01 | 8.1e-01 | 7.0e-02 |
| 504 | (REACTOME) GRB2 events in ERBB2 signaling | 8.3e-01 | 9.7e-01 | 6.0e-01 | 8.7e-01 | 8.5e-01 | 3.7e-01 |
| 676 | (REACTOME) Activation of the phototransduction cascade | 8.3e-01 | 9.4e-01 | 9.2e-01 | 8.9e-01 | 9.5e-01 | 7.2e-01 |
| 1358 | (REACTOME) tRNA processing in the mitochondrion | 8.3e-01 | 7.0e-01 | 6.0e-01 | 7.0e-01 | 5.1e-01 | 7.3e-01 |
| 1361 | (REACTOME) tRNA modification in the mitochondrion | 8.3e-01 | 7.0e-01 | 6.0e-01 | 7.0e-01 | 5.1e-01 | 7.3e-01 |
| 1715 | (REACTOME) Transcriptional Regulation by E2F6 | 8.3e-01 | 7.0e-01 | 7.9e-01 | 1.0e+00 | 9.1e-01 | 1.0e+00 |
| 1952 | (REACTOME) Vitamins B6 activation to pyridoxal phosphate | 8.3e-01 | 4.5e-01 | 8.9e-01 | 9.0e-01 | 7.2e-01 | 9.3e-01 |
| 728 | (REACTOME) Scavenging by Class A Receptors | 8.3e-01 | 8.6e-01 | 6.2e-01 | 1.0e+00 | 4.9e-01 | 2.2e-01 |
| 1567 | (REACTOME) Platelet activation, signaling and aggregation | 8.3e-01 | 9.3e-01 | 8.3e-01 | 8.7e-01 | 4.9e-01 | 1.6e-01 |
| 883 | (REACTOME) Signal regulatory protein family interactions | 8.3e-01 | 8.8e-01 | 9.6e-01 | 9.1e-01 | 8.3e-01 | 4.5e-01 |
| 1173 | (REACTOME) Hedgehog ‘off’ state | 8.3e-01 | 7.6e-01 | 7.8e-01 | 1.0e+00 | 4.6e-01 | 7.0e-02 |
| 1221 | (REACTOME) Fructose biosynthesis | 8.3e-01 | 9.7e-01 | 6.5e-01 | 8.9e-01 | 5.6e-01 | 4.9e-01 |
| 1624 | (REACTOME) RET signaling | 8.3e-01 | 9.0e-01 | 8.3e-01 | 9.9e-01 | 5.7e-01 | 9.2e-01 |
| 1944 | (REACTOME) STAT5 Activation | 8.3e-01 | 7.5e-01 | 8.3e-01 | 9.4e-01 | 7.6e-01 | 6.9e-01 |
| 181 | (REACTOME) PI Metabolism | 8.3e-01 | 5.1e-01 | 6.0e-01 | 8.3e-01 | 6.3e-01 | 8.5e-01 |
| 1769 | (REACTOME) Rab regulation of trafficking | 8.3e-01 | 4.6e-01 | 6.0e-01 | 9.8e-01 | 4.3e-01 | 4.8e-01 |
| 2146 | (REACTOME) Termination of O-glycan biosynthesis | 8.3e-01 | 8.4e-01 | 8.5e-01 | 9.1e-01 | 5.6e-01 | 8.7e-01 |
| 1161 | (REACTOME) TRAF3 deficiency - HSE | 8.3e-01 | 4.7e-01 | 4.7e-01 | 8.2e-01 | 7.7e-01 | 9.7e-01 |
| 2152 | (REACTOME) GABA B receptor activation | 8.3e-01 | 8.3e-01 | 9.5e-01 | 9.1e-01 | 7.2e-01 | 7.1e-01 |
| 2164 | (REACTOME) Activation of GABAB receptors | 8.3e-01 | 8.3e-01 | 9.5e-01 | 9.1e-01 | 7.2e-01 | 7.1e-01 |
| 503 | (REACTOME) Beta-catenin phosphorylation cascade | 8.3e-01 | 9.1e-01 | 9.0e-01 | 9.0e-01 | 8.4e-01 | 1.0e+00 |
| 860 | (REACTOME) Receptor-type tyrosine-protein phosphatases | 8.3e-01 | 3.7e-01 | 8.5e-01 | 9.1e-01 | 3.7e-01 | 4.5e-01 |
| 898 | (REACTOME) Activation of AMPA receptors | 8.3e-01 | 8.1e-01 | 8.6e-01 | 9.4e-01 | 5.7e-01 | 1.7e-01 |
| 908 | (REACTOME) Free fatty acids regulate insulin secretion | 8.3e-01 | 6.4e-01 | 7.9e-01 | 8.2e-01 | 8.4e-01 | 7.9e-01 |
| 1544 | (REACTOME) Signal attenuation | 8.3e-01 | 4.7e-01 | 9.7e-01 | 9.2e-01 | 1.4e-01 | 3.6e-01 |
| 708 | (REACTOME) Ficolins bind to repetitive carbohydrate structures on the target cell surface | 8.3e-01 | 9.5e-01 | 8.3e-01 | 9.6e-01 | 7.9e-01 | 7.7e-01 |
| 1515 | (REACTOME) RNA Polymerase I Promoter Escape | 8.3e-01 | 6.1e-01 | 6.0e-01 | 9.0e-01 | 2.7e-01 | 2.9e-01 |
| 1691 | (REACTOME) RUNX2 regulates bone development | 8.3e-01 | 4.4e-01 | 9.8e-01 | 8.4e-01 | 6.7e-01 | 8.2e-01 |
| 1925 | (REACTOME) GPER1 signaling | 8.3e-01 | 8.8e-01 | 7.8e-01 | 9.8e-01 | 9.3e-01 | 9.0e-02 |
| 530 | (REACTOME) Vitamin B5 (pantothenate) metabolism | 8.3e-01 | 5.2e-01 | 9.9e-01 | 3.0e-01 | 9.6e-01 | 6.6e-01 |
| 2038 | (REACTOME) Aberrant regulation of mitotic exit in cancer due to RB1 defects | 8.3e-01 | 3.4e-01 | 8.9e-01 | 1.0e+00 | 6.7e-01 | 1.6e-01 |
| 595 | (REACTOME) Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | 8.3e-01 | 6.7e-01 | 9.2e-01 | 9.1e-01 | 9.4e-01 | 7.9e-01 |
| 882 | (REACTOME) Peroxisomal lipid metabolism | 8.3e-01 | 5.4e-01 | 9.2e-01 | 9.4e-01 | 9.8e-01 | 1.0e+00 |
| 157 | (REACTOME) Alpha-defensins | 8.4e-01 | 1.0e+00 | 8.9e-01 | 1.0e+00 | 6.1e-01 | 8.7e-01 |
| 1542 | (REACTOME) Purine catabolism | 8.4e-01 | 4.4e-01 | 9.2e-01 | 9.9e-01 | 4.6e-01 | 8.2e-01 |
| 1442 | (REACTOME) G1/S-Specific Transcription | 8.4e-01 | 9.9e-01 | 8.7e-01 | 8.5e-01 | 9.4e-01 | 1.0e+00 |
| 2083 | (REACTOME) Cytoprotection by HMOX1 | 8.4e-01 | 8.1e-01 | 9.5e-01 | 9.3e-01 | 3.2e-01 | 6.0e-01 |
| 1666 | (REACTOME) RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 8.4e-01 | 4.4e-01 | 9.9e-01 | 9.4e-01 | 6.0e-01 | 5.0e-01 |
| 158 | (REACTOME) Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 8.4e-01 | 8.2e-01 | 9.6e-01 | 9.4e-01 | 9.8e-01 | 7.9e-01 |
| 630 | (REACTOME) Transcriptional activation of mitochondrial biogenesis | 8.4e-01 | 7.3e-01 | 8.9e-01 | 8.5e-01 | 9.7e-01 | 4.2e-01 |
| 1587 | (REACTOME) Beta oxidation of butanoyl-CoA to acetyl-CoA | 8.4e-01 | 5.4e-01 | 9.7e-01 | 9.6e-01 | 9.9e-01 | 8.2e-01 |
| 1842 | (REACTOME) Erythropoietin activates Phospholipase C gamma (PLCG) | 8.4e-01 | 4.4e-01 | 9.5e-01 | 8.5e-01 | 3.3e-01 | 2.8e-01 |
| 1841 | (REACTOME) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 8.4e-01 | 7.7e-01 | 9.2e-01 | 9.4e-01 | 3.3e-01 | 8.4e-01 |
| 267 | (REACTOME) Collagen biosynthesis and modifying enzymes | 8.4e-01 | 6.0e-02 | 6.0e-01 | 1.0e+00 | 4.6e-01 | 0.0e+00 |
| 1100 | (REACTOME) Toxicity of botulinum toxin type C (botC) | 8.4e-01 | 9.1e-01 | 9.2e-01 | 8.5e-01 | 2.6e-01 | 7.8e-01 |
| 1520 | (REACTOME) RNA Polymerase I Promoter Clearance | 8.4e-01 | 9.2e-01 | 7.7e-01 | 9.6e-01 | 4.5e-01 | 5.3e-01 |
| 1524 | (REACTOME) RNA Polymerase I Transcription | 8.4e-01 | 9.2e-01 | 7.7e-01 | 9.6e-01 | 4.5e-01 | 5.3e-01 |
| 1533 | (REACTOME) Abasic sugar-phosphate removal via the single-nucleotide replacement pathway | 8.4e-01 | 2.8e-01 | 9.2e-01 | 7.8e-01 | 2.1e-01 | 6.3e-01 |
| 2075 | (REACTOME) SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.4e-01 | 3.7e-01 | 9.6e-01 | 9.5e-01 | 6.1e-01 | 4.4e-01 |
| 1488 | (REACTOME) Citric acid cycle (TCA cycle) | 8.4e-01 | 4.8e-01 | 7.3e-01 | 9.0e-01 | 7.7e-01 | 3.0e-01 |
| 686 | (REACTOME) Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 8.4e-01 | 5.0e-01 | 8.5e-01 | 9.4e-01 | 5.6e-01 | 1.0e+00 |
| 2137 | (REACTOME) Cobalamin (Cbl) metabolism | 8.4e-01 | 4.4e-01 | 6.0e-01 | 9.5e-01 | 6.6e-01 | 3.7e-01 |
| 2155 | (REACTOME) Growth hormone receptor signaling | 8.4e-01 | 4.4e-01 | 8.3e-01 | 8.4e-01 | 1.7e-01 | 3.7e-01 |
| 1497 | (REACTOME) Processing of Capped Intron-Containing Pre-mRNA | 8.4e-01 | 4.2e-01 | 5.6e-01 | 7.9e-01 | 1.0e-02 | 3.0e-02 |
| 1150 | (REACTOME) Phase 2 - plateau phase | 8.4e-01 | 6.1e-01 | 7.5e-01 | 9.1e-01 | 9.8e-01 | 7.3e-01 |
| 1837 | (REACTOME) Biosynthesis of DPAn-3-derived maresins | 8.4e-01 | 4.4e-01 | 9.3e-01 | 1.0e+00 | 5.5e-01 | 6.3e-01 |
| 289 | (REACTOME) Creation of C4 and C2 activators | 8.5e-01 | 2.9e-01 | 9.6e-01 | 8.5e-01 | 6.2e-01 | 8.1e-01 |
| 1534 | (REACTOME) Resolution of Abasic Sites (AP sites) | 8.5e-01 | 3.8e-01 | 6.0e-01 | 8.8e-01 | 7.7e-01 | 3.2e-01 |
| 1653 | (REACTOME) RAB geranylgeranylation | 8.5e-01 | 9.4e-01 | 1.0e+00 | 9.9e-01 | 5.4e-01 | 7.6e-01 |
| 1904 | (REACTOME) Lipophagy | 8.5e-01 | 8.2e-01 | 6.4e-01 | 9.4e-01 | 2.9e-01 | 3.0e-01 |
| 1980 | (REACTOME) LTC4-CYSLTR mediated IL4 production | 8.5e-01 | 6.8e-01 | 8.7e-01 | 9.1e-01 | 7.1e-01 | 3.7e-01 |
| 266 | (REACTOME) Rev-mediated nuclear export of HIV RNA | 8.5e-01 | 8.0e-01 | 9.6e-01 | 1.0e+00 | 9.1e-01 | 5.1e-01 |
| 743 | (REACTOME) RMTs methylate histone arginines | 8.5e-01 | 8.1e-01 | 5.2e-01 | 9.5e-01 | 9.9e-01 | 8.1e-01 |
| 1421 | (REACTOME) Mitotic Prophase | 8.5e-01 | 8.7e-01 | 9.1e-01 | 9.9e-01 | 9.9e-01 | 2.1e-01 |
| 1438 | (REACTOME) Lagging Strand Synthesis | 8.5e-01 | 5.0e-01 | 6.7e-01 | 8.5e-01 | 6.4e-01 | 8.2e-01 |
| 142 | (REACTOME) Common Pathway of Fibrin Clot Formation | 8.5e-01 | 8.1e-01 | 9.6e-01 | 9.1e-01 | 9.4e-01 | 8.0e-02 |
| 240 | (REACTOME) Mitochondrial transcription initiation | 8.5e-01 | 9.5e-01 | 9.7e-01 | 8.5e-01 | 9.4e-01 | 2.6e-01 |
| 291 | (REACTOME) Signalling to RAS | 8.5e-01 | 9.1e-01 | 8.6e-01 | 1.0e+00 | 1.5e-01 | 2.7e-01 |
| 1564 | (REACTOME) Transcription from mitochondrial promoters | 8.5e-01 | 9.5e-01 | 9.7e-01 | 8.5e-01 | 9.4e-01 | 2.6e-01 |
| 876 | (REACTOME) Folding of actin by CCT/TriC | 8.5e-01 | 5.2e-01 | 7.3e-01 | 1.0e+00 | 3.5e-01 | 6.9e-01 |
| 107 | (REACTOME) Interleukin-7 signaling | 8.5e-01 | 7.6e-01 | 9.5e-01 | 9.0e-01 | 2.1e-01 | 9.3e-01 |
| 463 | (REACTOME) Pre-NOTCH Transcription and Translation | 8.5e-01 | 7.0e-02 | 7.1e-01 | 8.3e-01 | 7.2e-01 | 3.3e-01 |
| 29 | (REACTOME) SMAC (DIABLO) binds to IAPs | 8.5e-01 | 9.2e-01 | 8.6e-01 | 9.4e-01 | 9.2e-01 | 6.1e-01 |
| 30 | (REACTOME) SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 8.5e-01 | 9.2e-01 | 8.6e-01 | 9.4e-01 | 9.2e-01 | 6.1e-01 |
| 32 | (REACTOME) SMAC, XIAP-regulated apoptotic response | 8.5e-01 | 9.2e-01 | 8.6e-01 | 9.4e-01 | 9.2e-01 | 6.1e-01 |
| 175 | (REACTOME) Synthesis of PC | 8.5e-01 | 6.8e-01 | 8.2e-01 | 9.1e-01 | 5.2e-01 | 8.0e-01 |
| 1684 | (REACTOME) RUNX1 regulates transcription of genes involved in differentiation of myeloid cells | 8.5e-01 | 8.1e-01 | 9.3e-01 | 9.9e-01 | 6.1e-01 | 8.8e-01 |
| 1713 | (REACTOME) RUNX3 regulates p14-ARF | 8.5e-01 | 1.1e-01 | 6.1e-01 | 7.3e-01 | 6.9e-01 | 3.8e-01 |
| 2068 | (REACTOME) STAT3 nuclear events downstream of ALK signaling | 8.5e-01 | 9.4e-01 | 8.3e-01 | 9.4e-01 | 6.9e-01 | 3.1e-01 |
| 2077 | (REACTOME) SARS-CoV-2-host interactions | 8.5e-01 | 6.1e-01 | 9.8e-01 | 9.3e-01 | 8.6e-01 | 3.1e-01 |
| 104 | (REACTOME) Nuclear signaling by ERBB4 | 8.5e-01 | 3.4e-01 | 6.4e-01 | 8.5e-01 | 1.4e-01 | 9.0e-02 |
| 721 | (REACTOME) Initiation of Nuclear Envelope (NE) Reformation | 8.5e-01 | 4.4e-01 | 9.8e-01 | 9.4e-01 | 8.0e-01 | 1.0e+00 |
| 1000 | (REACTOME) Interaction between L1 and Ankyrins | 8.5e-01 | 4.4e-01 | 7.7e-01 | 9.4e-01 | 9.2e-01 | 6.0e-01 |
| 374 | (REACTOME) Removal of the Flap Intermediate from the C-strand | 8.5e-01 | 4.1e-01 | 8.5e-01 | 9.4e-01 | 7.4e-01 | 7.2e-01 |
| 819 | (REACTOME) Diseases associated with N-glycosylation of proteins | 8.5e-01 | 9.1e-01 | 9.7e-01 | 9.1e-01 | 8.5e-01 | 7.9e-01 |
| 1429 | (REACTOME) DNA replication initiation | 8.5e-01 | 8.8e-01 | 6.0e-01 | 9.4e-01 | 8.9e-01 | 7.8e-01 |
| 2123 | (REACTOME) Ribavirin ADME | 8.5e-01 | 4.9e-01 | 7.3e-01 | 9.6e-01 | 3.5e-01 | 5.6e-01 |
| 144 | (REACTOME) Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | 8.5e-01 | 3.4e-01 | 9.4e-01 | 1.0e+00 | 8.4e-01 | 1.5e-01 |
| 146 | (REACTOME) Inactivation of APC/C via direct inhibition of the APC/C complex | 8.5e-01 | 3.4e-01 | 9.4e-01 | 1.0e+00 | 8.4e-01 | 1.5e-01 |
| 2050 | (REACTOME) SARS-CoV-2 Infection | 8.5e-01 | 8.3e-01 | 9.2e-01 | 1.0e+00 | 7.5e-01 | 5.6e-01 |
| 38 | (REACTOME) Cam-PDE 1 activation | 8.5e-01 | 8.1e-01 | 7.8e-01 | 9.4e-01 | 5.7e-01 | 6.6e-01 |
| 165 | (REACTOME) Acyl chain remodeling of CL | 8.5e-01 | 9.6e-01 | 9.6e-01 | 9.8e-01 | 8.2e-01 | 7.6e-01 |
| 538 | (REACTOME) Signaling by ALK | 8.5e-01 | 6.1e-01 | 8.3e-01 | 9.5e-01 | 3.3e-01 | 2.8e-01 |
| 653 | (REACTOME) Constitutive Signaling by Aberrant PI3K in Cancer | 8.5e-01 | 3.3e-01 | 7.9e-01 | 9.4e-01 | 3.7e-01 | 6.1e-01 |
| 985 | (REACTOME) Unblocking of NMDA receptors, glutamate binding and activation | 8.5e-01 | 9.2e-01 | 9.3e-01 | 1.0e+00 | 4.0e-01 | 7.9e-01 |
| 1523 | (REACTOME) RNA Polymerase I Transcription Termination | 8.5e-01 | 7.1e-01 | 6.0e-01 | 9.1e-01 | 2.5e-01 | 2.5e-01 |
| 1738 | (REACTOME) LDL remodeling | 8.5e-01 | 4.6e-01 | 8.9e-01 | 9.1e-01 | 4.8e-01 | 9.0e-01 |
| 1818 | (REACTOME) Interleukin-12 signaling | 8.5e-01 | 6.1e-01 | 8.6e-01 | 9.4e-01 | 6.4e-01 | 4.6e-01 |
| 1124 | (REACTOME) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 8.5e-01 | 9.6e-01 | 5.6e-01 | 9.0e-01 | 3.8e-01 | 1.0e+00 |
| 674 | (REACTOME) Antagonism of Activin by Follistatin | 8.5e-01 | 6.8e-01 | 8.5e-01 | 7.8e-01 | 5.1e-01 | 3.3e-01 |
| 1785 | (REACTOME) RHOD GTPase cycle | 8.5e-01 | 6.9e-01 | 7.2e-01 | 9.4e-01 | 7.9e-01 | 7.5e-01 |
| 102 | (REACTOME) SHC1 events in ERBB4 signaling | 8.5e-01 | 9.2e-01 | 6.0e-01 | 9.0e-01 | 9.7e-01 | 6.6e-01 |
| 494 | (REACTOME) Signaling by Rho GTPases | 8.5e-01 | 2.0e-02 | 8.3e-01 | 9.9e-01 | 8.6e-01 | 4.0e-02 |
| 596 | (REACTOME) Regulation of gene expression in beta cells | 8.5e-01 | 9.0e-01 | 8.3e-01 | 9.1e-01 | 5.5e-01 | 3.0e-02 |
| 763 | (REACTOME) Defective MTRR causes HMAE | 8.5e-01 | 4.9e-01 | 6.0e-01 | 9.4e-01 | 9.7e-01 | 3.4e-01 |
| 764 | (REACTOME) Defective MTR causes HMAG | 8.5e-01 | 4.9e-01 | 6.0e-01 | 9.4e-01 | 9.7e-01 | 3.4e-01 |
| 1194 | (REACTOME) Trafficking of myristoylated proteins to the cilium | 8.5e-01 | 8.8e-01 | 7.4e-01 | 9.8e-01 | 9.3e-01 | 7.1e-01 |
| 1498 | (REACTOME) tRNA processing | 8.5e-01 | 4.4e-01 | 6.1e-01 | 9.2e-01 | 3.2e-01 | 4.0e-02 |
| 1613 | (REACTOME) PTK6 Expression | 8.5e-01 | 9.0e-01 | 6.0e-01 | 9.4e-01 | 8.7e-01 | 4.3e-01 |
| 1629 | (REACTOME) Interaction between PHLDA1 and AURKA | 8.5e-01 | 7.0e-01 | 6.0e-01 | 8.5e-01 | 9.2e-01 | 3.0e-01 |
| 1672 | (REACTOME) RUNX1 regulates estrogen receptor mediated transcription | 8.5e-01 | 3.4e-01 | 8.8e-01 | 8.9e-01 | 3.8e-01 | 8.0e-01 |
| 1732 | (REACTOME) Plasma lipoprotein assembly | 8.5e-01 | 8.5e-01 | 9.2e-01 | 9.4e-01 | 6.3e-01 | 7.9e-01 |
| 1838 | (REACTOME) NTF4 activates NTRK2 (TRKB) signaling | 8.5e-01 | 8.3e-01 | 8.7e-01 | 9.4e-01 | 7.9e-01 | 8.9e-01 |
| 1881 | (REACTOME) NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 8.5e-01 | 4.4e-01 | 9.2e-01 | 9.5e-01 | 3.4e-01 | 7.9e-01 |
| 1956 | (REACTOME) Drug-mediated inhibition of ERBB2 signaling | 8.5e-01 | 7.2e-01 | 8.7e-01 | 9.4e-01 | 8.9e-01 | 9.8e-01 |
| 1983 | (REACTOME) Drug resistance in ERBB2 KD mutants | 8.5e-01 | 7.2e-01 | 8.7e-01 | 9.4e-01 | 8.9e-01 | 9.8e-01 |
| 1984 | (REACTOME) Resistance of ERBB2 KD mutants to trastuzumab | 8.5e-01 | 7.2e-01 | 8.7e-01 | 9.4e-01 | 8.9e-01 | 9.8e-01 |
| 1985 | (REACTOME) Resistance of ERBB2 KD mutants to sapitinib | 8.5e-01 | 7.2e-01 | 8.7e-01 | 9.4e-01 | 8.9e-01 | 9.8e-01 |
| 1986 | (REACTOME) Resistance of ERBB2 KD mutants to tesevatinib | 8.5e-01 | 7.2e-01 | 8.7e-01 | 9.4e-01 | 8.9e-01 | 9.8e-01 |
| 1987 | (REACTOME) Resistance of ERBB2 KD mutants to neratinib | 8.5e-01 | 7.2e-01 | 8.7e-01 | 9.4e-01 | 8.9e-01 | 9.8e-01 |
| 1988 | (REACTOME) Resistance of ERBB2 KD mutants to osimertinib | 8.5e-01 | 7.2e-01 | 8.7e-01 | 9.4e-01 | 8.9e-01 | 9.8e-01 |
| 1989 | (REACTOME) Resistance of ERBB2 KD mutants to afatinib | 8.5e-01 | 7.2e-01 | 8.7e-01 | 9.4e-01 | 8.9e-01 | 9.8e-01 |
| 1990 | (REACTOME) Resistance of ERBB2 KD mutants to AEE788 | 8.5e-01 | 7.2e-01 | 8.7e-01 | 9.4e-01 | 8.9e-01 | 9.8e-01 |
| 1991 | (REACTOME) Resistance of ERBB2 KD mutants to lapatinib | 8.5e-01 | 7.2e-01 | 8.7e-01 | 9.4e-01 | 8.9e-01 | 9.8e-01 |
| 1994 | (REACTOME) Drug resistance in ERBB2 TMD/JMD mutants | 8.5e-01 | 7.2e-01 | 8.7e-01 | 9.4e-01 | 8.9e-01 | 9.8e-01 |
| 2095 | (REACTOME) Signaling by Rho GTPases, Miro GTPases and RHOBTB3 | 8.5e-01 | 2.0e-02 | 8.4e-01 | 9.9e-01 | 8.9e-01 | 3.0e-02 |
| 483 | (REACTOME) Regulated proteolysis of p75NTR | 8.6e-01 | 6.9e-01 | 7.9e-01 | 8.5e-01 | 6.4e-01 | 5.6e-01 |
| 1418 | (REACTOME) Assembly of the ORC complex at the origin of replication | 8.6e-01 | 9.0e-01 | 6.6e-01 | 8.5e-01 | 5.4e-01 | 1.0e+00 |
| 1843 | (REACTOME) Erythropoietin activates STAT5 | 8.6e-01 | 5.0e-01 | 9.3e-01 | 8.5e-01 | 2.1e-01 | 4.7e-01 |
| 263 | (REACTOME) Nef mediated downregulation of MHC class I complex cell surface expression | 8.6e-01 | 9.1e-01 | 9.8e-01 | 9.9e-01 | 6.6e-01 | 5.8e-01 |
| 124 | (REACTOME) Acrosome Reaction and Sperm:Oocyte Membrane Binding | 8.6e-01 | 8.9e-01 | 1.0e+00 | 9.4e-01 | 9.9e-01 | 2.9e-01 |
| 132 | (REACTOME) RORA activates gene expression | 8.6e-01 | 6.4e-01 | 7.8e-01 | 9.5e-01 | 9.8e-01 | 2.4e-01 |
| 210 | (REACTOME) Activation of Matrix Metalloproteinases | 8.6e-01 | 4.8e-01 | 7.8e-01 | 9.5e-01 | 8.6e-01 | 7.9e-01 |
| 371 | (REACTOME) Processive synthesis on the C-strand of the telomere | 8.6e-01 | 3.8e-01 | 8.5e-01 | 9.4e-01 | 8.5e-01 | 7.4e-01 |
| 559 | (REACTOME) Calcineurin activates NFAT | 8.6e-01 | 9.2e-01 | 8.3e-01 | 9.4e-01 | 4.2e-01 | 9.4e-01 |
| 1439 | (REACTOME) DNA strand elongation | 8.6e-01 | 4.4e-01 | 6.0e-01 | 9.2e-01 | 6.6e-01 | 8.6e-01 |
| 1690 | (REACTOME) RUNX2 regulates chondrocyte maturation | 8.6e-01 | 5.3e-01 | 8.7e-01 | 8.5e-01 | 1.0e+00 | 8.9e-01 |
| 465 | (REACTOME) Pre-NOTCH Expression and Processing | 8.6e-01 | 3.4e-01 | 8.7e-01 | 7.9e-01 | 5.1e-01 | 4.2e-01 |
| 467 | (REACTOME) Regulation of gap junction activity | 8.6e-01 | 5.4e-01 | 8.7e-01 | 9.0e-01 | 4.2e-01 | 8.0e-01 |
| 527 | (REACTOME) Signalling to ERK5 | 8.6e-01 | 8.1e-01 | 6.0e-01 | 9.4e-01 | 7.9e-01 | 7.3e-01 |
| 1586 | (REACTOME) Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 8.6e-01 | 4.1e-01 | 9.0e-01 | 9.2e-01 | 9.2e-01 | 5.8e-01 |
| 691 | (REACTOME) Regulation of PLK1 Activity at G2/M Transition | 8.6e-01 | 9.8e-01 | 8.5e-01 | 1.0e+00 | 8.0e-01 | 4.3e-01 |
| 754 | (REACTOME) Detoxification of Reactive Oxygen Species | 8.6e-01 | 7.1e-01 | 1.0e+00 | 9.2e-01 | 5.3e-01 | 3.6e-01 |
| 992 | (REACTOME) CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 8.6e-01 | 6.5e-01 | 9.2e-01 | 8.2e-01 | 7.7e-01 | 8.9e-01 |
| 1005 | (REACTOME) Type I hemidesmosome assembly | 8.6e-01 | 2.5e-01 | 6.0e-01 | 9.7e-01 | 5.6e-01 | 3.7e-01 |
| 151 | (REACTOME) Regulation of KIT signaling | 8.6e-01 | 8.1e-01 | 8.3e-01 | 9.5e-01 | 8.0e-01 | 5.9e-01 |
| 546 | (REACTOME) Keratan sulfate biosynthesis | 8.6e-01 | 8.1e-01 | 7.3e-01 | 9.4e-01 | 4.3e-01 | 4.0e-02 |
| 610 | (REACTOME) Endogenous sterols | 8.6e-01 | 2.9e-01 | 8.5e-01 | 1.0e+00 | 8.8e-01 | 7.5e-01 |
| 987 | (REACTOME) Depolymerisation of the Nuclear Lamina | 8.6e-01 | 9.9e-01 | 9.4e-01 | 9.5e-01 | 8.4e-01 | 6.0e-01 |
| 1849 | (REACTOME) LXRs regulate gene expression to limit cholesterol uptake | 8.6e-01 | 6.4e-01 | 8.5e-01 | 9.4e-01 | 3.7e-01 | 7.9e-01 |
| 1970 | (REACTOME) CD163 mediating an anti-inflammatory response | 8.6e-01 | 1.7e-01 | 7.1e-01 | 7.8e-01 | 6.1e-01 | 4.5e-01 |
| 1073 | (REACTOME) Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 | 8.6e-01 | 8.9e-01 | 7.4e-01 | 8.5e-01 | 7.2e-01 | 4.7e-01 |
| 1834 | (REACTOME) NTF3 activates NTRK2 (TRKB) signaling | 8.6e-01 | 8.0e-01 | 8.5e-01 | 9.2e-01 | 8.9e-01 | 8.1e-01 |
| 248 | (REACTOME) Insulin effects increased synthesis of Xylulose-5-Phosphate | 8.7e-01 | 5.2e-01 | 9.5e-01 | 9.4e-01 | 7.0e-01 | 9.0e-01 |
| 2088 | (REACTOME) Impaired BRCA2 binding to RAD51 | 8.7e-01 | 6.5e-01 | 6.0e-01 | 9.4e-01 | 7.2e-01 | 1.0e+00 |
| 2153 | (REACTOME) Regulation of Complement cascade | 8.7e-01 | 6.9e-01 | 9.2e-01 | 6.6e-01 | 9.8e-01 | 1.1e-01 |
| 40 | (REACTOME) Ca-dependent events | 8.7e-01 | 7.4e-01 | 9.8e-01 | 9.6e-01 | 8.3e-01 | 4.3e-01 |
| 346 | (REACTOME) Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes | 8.7e-01 | 9.2e-01 | 1.0e+00 | 9.4e-01 | 6.9e-01 | 1.0e+00 |
| 437 | (REACTOME) TRKA activation by NGF | 8.7e-01 | 7.7e-01 | 9.1e-01 | 9.6e-01 | 7.7e-01 | 8.1e-01 |
| 813 | (REACTOME) Amine ligand-binding receptors | 8.7e-01 | 7.0e-01 | 1.0e-02 | 9.4e-01 | 2.8e-01 | 5.0e-02 |
| 815 | (REACTOME) DSCAM interactions | 8.7e-01 | 8.6e-01 | 6.0e-01 | 9.1e-01 | 9.3e-01 | 7.0e-02 |
| 880 | (REACTOME) Adrenoceptors | 8.7e-01 | 7.0e-01 | 1.0e-02 | 9.4e-01 | 2.8e-01 | 5.0e-02 |
| 956 | (REACTOME) Small interfering RNA (siRNA) biogenesis | 8.7e-01 | 8.2e-01 | 8.5e-01 | 9.8e-01 | 6.4e-01 | 9.4e-01 |
| 995 | (REACTOME) Ras activation upon Ca2+ influx through NMDA receptor | 8.7e-01 | 8.8e-01 | 9.4e-01 | 1.0e+00 | 4.7e-01 | 6.6e-01 |
| 1061 | (REACTOME) Signaling by WNT in cancer | 8.7e-01 | 9.6e-01 | 9.1e-01 | 9.1e-01 | 7.2e-01 | 6.2e-01 |
| 1122 | (REACTOME) MMR | 8.7e-01 | 9.1e-01 | 5.2e-01 | 9.1e-01 | 4.2e-01 | 1.0e+00 |
| 1149 | (REACTOME) Phase 0 - rapid depolarisation | 8.7e-01 | 5.8e-01 | 8.5e-01 | 9.1e-01 | 5.8e-01 | 6.8e-01 |
| 1288 | (REACTOME) TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 8.7e-01 | 1.6e-01 | 9.7e-01 | 9.4e-01 | 8.4e-01 | 1.0e+00 |
| 1779 | (REACTOME) RHO GTPase cycle | 8.7e-01 | 0.0e+00 | 8.5e-01 | 9.7e-01 | 6.0e-01 | 2.0e-02 |
| 1787 | (REACTOME) RHOH GTPase cycle | 8.7e-01 | 7.2e-01 | 6.0e-01 | 4.0e-01 | 7.3e-01 | 7.1e-01 |
| 1030 | (REACTOME) Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 8.7e-01 | 8.9e-01 | 7.9e-01 | 9.4e-01 | 6.5e-01 | 7.3e-01 |
| 154 | (REACTOME) Translocation of SLC2A4 (GLUT4) to the plasma membrane | 8.7e-01 | 8.9e-01 | 9.4e-01 | 9.4e-01 | 7.9e-01 | 4.0e-01 |
| 1187 | (REACTOME) Cargo trafficking to the periciliary membrane | 8.7e-01 | 4.1e-01 | 7.8e-01 | 9.4e-01 | 7.2e-01 | 6.5e-01 |
| 1592 | (REACTOME) Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane | 8.7e-01 | 4.2e-01 | 8.0e-01 | 9.4e-01 | 9.4e-01 | 7.9e-01 |
| 1718 | (REACTOME) Carboxyterminal post-translational modifications of tubulin | 8.7e-01 | 9.5e-01 | 6.4e-01 | 8.5e-01 | 7.7e-01 | 7.4e-01 |
| 36 | (REACTOME) CaMK IV-mediated phosphorylation of CREB | 8.7e-01 | 5.6e-01 | 8.7e-01 | 8.2e-01 | 8.9e-01 | 7.1e-01 |
| 1992 | (REACTOME) Signaling by ERBB2 ECD mutants | 8.7e-01 | 8.0e-01 | 9.1e-01 | 9.1e-01 | 9.4e-01 | 4.7e-01 |
| 2004 | (REACTOME) Defective F8 cleavage by thrombin | 8.7e-01 | 5.6e-01 | 9.9e-01 | 9.5e-01 | 8.5e-01 | 6.6e-01 |
| 2087 | (REACTOME) Impaired BRCA2 translocation to the nucleus | 8.7e-01 | 5.4e-01 | 9.9e-01 | 9.2e-01 | 6.1e-01 | 6.3e-01 |
| 1901 | (REACTOME) Assembly and cell surface presentation of NMDA receptors | 8.7e-01 | 8.9e-01 | 8.8e-01 | 9.4e-01 | 8.7e-01 | 7.5e-01 |
| 468 | (REACTOME) snRNP Assembly | 8.7e-01 | 9.3e-01 | 9.0e-01 | 9.2e-01 | 6.5e-01 | 2.6e-01 |
| 495 | (REACTOME) Non-coding RNA Metabolism | 8.7e-01 | 9.3e-01 | 9.0e-01 | 9.2e-01 | 6.5e-01 | 2.6e-01 |
| 963 | (REACTOME) Regulation of commissural axon pathfinding by SLIT and ROBO | 8.7e-01 | 9.1e-01 | 8.5e-01 | 9.4e-01 | 8.4e-01 | 7.2e-01 |
| 1802 | (REACTOME) TLR3-mediated TICAM1-dependent programmed cell death | 8.7e-01 | 5.2e-01 | 5.9e-01 | 8.5e-01 | 4.2e-01 | 3.5e-01 |
| 828 | (REACTOME) Tachykinin receptors bind tachykinins | 8.7e-01 | 1.0e+00 | 9.6e-01 | 8.5e-01 | 7.9e-01 | 4.9e-01 |
| 1320 | (REACTOME) Sensing of DNA Double Strand Breaks | 8.7e-01 | 9.2e-01 | 7.3e-01 | 8.5e-01 | 9.2e-01 | 5.9e-01 |
| 1289 | (REACTOME) Protein repair | 8.8e-01 | 9.4e-01 | 9.5e-01 | 9.4e-01 | 6.4e-01 | 4.2e-01 |
| 1352 | (REACTOME) Synthesis of wybutosine at G37 of tRNA(Phe) | 8.8e-01 | 9.7e-01 | 7.1e-01 | 9.9e-01 | 7.2e-01 | 4.4e-01 |
| 184 | (REACTOME) Meiosis | 8.8e-01 | 7.8e-01 | 6.0e-01 | 9.8e-01 | 9.2e-01 | 9.0e-01 |
| 1419 | (REACTOME) CDC6 association with the ORC:origin complex | 8.8e-01 | 5.3e-01 | 6.0e-01 | 8.5e-01 | 5.5e-01 | 9.4e-01 |
| 334 | (REACTOME) Viral RNP Complexes in the Host Cell Nucleus | 8.8e-01 | 3.8e-01 | 7.1e-01 | 8.9e-01 | 7.0e-01 | 5.4e-01 |
| 425 | (REACTOME) Signaling by activated point mutants of FGFR3 | 8.8e-01 | 9.2e-01 | 9.4e-01 | 9.8e-01 | 2.7e-01 | 7.4e-01 |
| 501 | (REACTOME) Metabolism of steroid hormones | 8.8e-01 | 4.6e-01 | 6.0e-01 | 9.4e-01 | 7.1e-01 | 5.0e-01 |
| 568 | (REACTOME) FGFR3 mutant receptor activation | 8.8e-01 | 9.2e-01 | 9.4e-01 | 9.8e-01 | 2.7e-01 | 7.4e-01 |
| 770 | (REACTOME) HSF1 activation | 8.8e-01 | 7.7e-01 | 9.5e-01 | 9.4e-01 | 8.0e-01 | 7.7e-01 |
| 784 | (REACTOME) Integrin signaling | 8.8e-01 | 5.7e-01 | 6.1e-01 | 9.5e-01 | 9.1e-01 | 6.8e-01 |
| 846 | (REACTOME) GSD XV | 8.8e-01 | 9.1e-01 | 6.7e-01 | 9.6e-01 | 9.8e-01 | 6.0e-01 |
| 852 | (REACTOME) GSD 0 (muscle) | 8.8e-01 | 9.1e-01 | 6.7e-01 | 9.6e-01 | 9.8e-01 | 6.0e-01 |
| 924 | (REACTOME) Platelet homeostasis | 8.8e-01 | 9.2e-01 | 8.5e-01 | 9.8e-01 | 8.5e-01 | 8.3e-01 |
| 1009 | (REACTOME) Synthesis of GDP-mannose | 8.8e-01 | 7.1e-01 | 9.6e-01 | 9.6e-01 | 6.0e-01 | 3.6e-01 |
| 1394 | (REACTOME) Regulation of TP53 Activity through Acetylation | 8.8e-01 | 9.2e-01 | 9.1e-01 | 9.6e-01 | 8.4e-01 | 8.7e-01 |
| 1820 | (REACTOME) Interleukin-23 signaling | 8.8e-01 | 9.1e-01 | 9.1e-01 | 9.2e-01 | 5.3e-01 | 6.6e-01 |
| 949 | (REACTOME) Transport of vitamins, nucleosides, and related molecules | 8.8e-01 | 5.3e-01 | 8.5e-01 | 9.4e-01 | 9.4e-01 | 8.4e-01 |
| 666 | (REACTOME) SHC-related events triggered by IGF1R | 8.8e-01 | 8.3e-01 | 8.7e-01 | 9.0e-01 | 9.9e-01 | 6.5e-01 |
| 180 | (REACTOME) Inositol phosphate metabolism | 8.8e-01 | 6.3e-01 | 8.3e-01 | 9.3e-01 | 6.6e-01 | 7.9e-01 |
| 295 | (REACTOME) RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 8.8e-01 | 4.6e-01 | 9.9e-01 | 8.6e-01 | 2.6e-01 | 1.0e-01 |
| 407 | (REACTOME) APOBEC3G mediated resistance to HIV-1 infection | 8.8e-01 | 9.4e-01 | 9.6e-01 | 8.5e-01 | 8.9e-01 | 6.0e-01 |
| 459 | (REACTOME) Gap junction trafficking | 8.8e-01 | 9.1e-01 | 9.1e-01 | 9.4e-01 | 6.4e-01 | 7.3e-01 |
| 651 | (REACTOME) Anchoring fibril formation | 8.8e-01 | 9.7e-01 | 6.2e-01 | 9.6e-01 | 7.9e-01 | 6.5e-01 |
| 1410 | (REACTOME) COPI-independent Golgi-to-ER retrograde traffic | 8.8e-01 | 9.1e-01 | 9.9e-01 | 8.5e-01 | 8.1e-01 | 7.9e-01 |
| 1575 | (REACTOME) RNA Pol II CTD phosphorylation and interaction with CE | 8.8e-01 | 4.6e-01 | 9.9e-01 | 8.6e-01 | 2.6e-01 | 1.0e-01 |
| 1760 | (REACTOME) Loss of function of MECP2 in Rett syndrome | 8.8e-01 | 8.9e-01 | 8.5e-01 | 9.4e-01 | 8.9e-01 | 6.9e-01 |
| 1761 | (REACTOME) Pervasive developmental disorders | 8.8e-01 | 8.9e-01 | 8.5e-01 | 9.4e-01 | 8.9e-01 | 6.9e-01 |
| 1855 | (REACTOME) Peroxisomal protein import | 8.8e-01 | 5.3e-01 | 6.0e-01 | 7.8e-01 | 4.9e-01 | 4.3e-01 |
| 1973 | (REACTOME) FCGR3A-mediated IL10 synthesis | 8.8e-01 | 7.6e-01 | 9.6e-01 | 9.8e-01 | 6.4e-01 | 4.0e-02 |
| 2019 | (REACTOME) Disorders of Developmental Biology | 8.8e-01 | 8.9e-01 | 8.5e-01 | 9.4e-01 | 8.9e-01 | 6.9e-01 |
| 2063 | (REACTOME) Disorders of Nervous System Development | 8.8e-01 | 8.9e-01 | 8.5e-01 | 9.4e-01 | 8.9e-01 | 6.9e-01 |
| 1226 | (REACTOME) Phospholipase C-mediated cascade; FGFR3 | 8.8e-01 | 9.2e-01 | 8.5e-01 | 9.8e-01 | 6.3e-01 | 8.1e-01 |
| 469 | (REACTOME) Synthesis of bile acids and bile salts | 8.8e-01 | 9.3e-01 | 6.0e-01 | 2.1e-01 | 8.4e-01 | 6.7e-01 |
| 2103 | (REACTOME) Induction of Cell-Cell Fusion | 8.8e-01 | 8.1e-01 | 8.3e-01 | 8.9e-01 | 6.9e-01 | 7.9e-01 |
| 791 | (REACTOME) Defective CHSY1 causes TPBS | 8.9e-01 | 8.7e-01 | 6.0e-01 | 8.5e-01 | 7.1e-01 | 5.0e-02 |
| 1372 | (REACTOME) Complex I biogenesis | 8.9e-01 | 4.0e-02 | 6.0e-01 | 7.9e-01 | 3.5e-01 | 5.0e-02 |
| 1476 | (REACTOME) Proline catabolism | 8.9e-01 | 7.4e-01 | 8.3e-01 | 9.3e-01 | 8.9e-01 | NA |
| 1099 | (REACTOME) Toxicity of botulinum toxin type A (botA) | 8.9e-01 | 9.5e-01 | 9.6e-01 | 8.5e-01 | 6.1e-01 | 6.9e-01 |
| 2117 | (REACTOME) APAP ADME | 8.9e-01 | 9.1e-01 | 6.0e-01 | 9.4e-01 | 9.4e-01 | 8.2e-01 |
| 2076 | (REACTOME) SARS-CoV-2 targets PDZ proteins in cell-cell junction | 8.9e-01 | 6.3e-01 | 8.7e-01 | 9.4e-01 | 7.2e-01 | 7.1e-01 |
| 37 | (REACTOME) Calmodulin induced events | 8.9e-01 | 8.1e-01 | 9.7e-01 | 9.4e-01 | 8.5e-01 | 6.4e-01 |
| 41 | (REACTOME) CaM pathway | 8.9e-01 | 8.1e-01 | 9.7e-01 | 9.4e-01 | 8.5e-01 | 6.4e-01 |
| 939 | (REACTOME) Glucagon-type ligand receptors | 8.9e-01 | 5.4e-01 | 6.0e-01 | 8.8e-01 | 8.6e-01 | 5.6e-01 |
| 869 | (REACTOME) SUMOylation of transcription cofactors | 8.9e-01 | 9.1e-01 | 9.7e-01 | 7.8e-01 | 8.9e-01 | 6.5e-01 |
| 482 | (REACTOME) Ceramide signalling | 8.9e-01 | 9.1e-01 | 9.6e-01 | 8.5e-01 | 6.1e-01 | 1.0e+00 |
| 707 | (REACTOME) Role of LAT2/NTAL/LAB on calcium mobilization | 8.9e-01 | 7.6e-01 | 8.7e-01 | 9.8e-01 | 8.1e-01 | 5.1e-01 |
| 727 | (REACTOME) Scavenging by Class B Receptors | 8.9e-01 | 9.7e-01 | 8.5e-01 | 9.4e-01 | 9.9e-01 | 7.1e-01 |
| 1869 | (REACTOME) Regulation of signaling by CBL | 8.9e-01 | 9.1e-01 | 8.6e-01 | 9.4e-01 | 6.9e-01 | 5.6e-01 |
| 2151 | (REACTOME) GABA receptor activation | 8.9e-01 | 9.1e-01 | 9.9e-01 | 9.1e-01 | 6.9e-01 | 6.7e-01 |
| 262 | (REACTOME) Nef mediated downregulation of CD28 cell surface expression | 8.9e-01 | 8.1e-01 | 9.1e-01 | 1.0e+00 | 8.6e-01 | 6.9e-01 |
| 1356 | (REACTOME) Glycine degradation | 8.9e-01 | 3.3e-01 | 9.1e-01 | 9.9e-01 | 9.4e-01 | 9.0e-01 |
| 773 | (REACTOME) HSF1-dependent transactivation | 8.9e-01 | 5.1e-01 | 6.6e-01 | 9.3e-01 | 9.2e-01 | 7.7e-01 |
| 962 | (REACTOME) Activation of RAC1 | 8.9e-01 | 8.3e-01 | 6.0e-01 | 9.5e-01 | 1.0e+00 | 9.1e-01 |
| 1401 | (REACTOME) MET Receptor Activation | 8.9e-01 | 7.2e-01 | 9.7e-01 | 9.0e-01 | 5.9e-01 | 3.6e-01 |
| 521 | (REACTOME) PI3K/AKT activation | 8.9e-01 | 7.8e-01 | 9.9e-01 | 9.4e-01 | 2.7e-01 | 8.3e-01 |
| 1080 | (REACTOME) WNT5A-dependent internalization of FZD4 | 8.9e-01 | 8.4e-01 | 9.9e-01 | 1.0e+00 | 3.3e-01 | 8.8e-01 |
| 680 | (REACTOME) Inactivation, recovery and regulation of the phototransduction cascade | 9.0e-01 | 9.2e-01 | 9.1e-01 | 9.1e-01 | 9.4e-01 | 6.5e-01 |
| 1367 | (REACTOME) rRNA modification in the mitochondrion | 9.0e-01 | 9.0e-01 | 9.4e-01 | 8.5e-01 | 7.1e-01 | 8.5e-01 |
| 1857 | (REACTOME) Blood group systems biosynthesis | 9.0e-01 | 9.1e-01 | 8.7e-01 | 7.8e-01 | 3.6e-01 | 4.0e-01 |
| 27 | (REACTOME) Activation of caspases through apoptosome-mediated cleavage | 9.0e-01 | 8.8e-01 | 8.6e-01 | 9.4e-01 | 9.2e-01 | 5.1e-01 |
| 582 | (REACTOME) NADE modulates death signalling | 9.0e-01 | 9.9e-01 | 7.6e-01 | 9.8e-01 | 9.7e-01 | 5.6e-01 |
| 62 | (REACTOME) E2F mediated regulation of DNA replication | 9.0e-01 | 6.1e-01 | 7.9e-01 | 8.9e-01 | 6.5e-01 | 8.9e-01 |
| 326 | (REACTOME) Influenza Virus Induced Apoptosis | 9.0e-01 | 9.4e-01 | 8.3e-01 | 9.4e-01 | 3.8e-01 | 7.3e-01 |
| 422 | (REACTOME) Signaling by activated point mutants of FGFR1 | 9.0e-01 | 8.1e-01 | 9.2e-01 | 9.0e-01 | 4.8e-01 | 7.5e-01 |
| 454 | (REACTOME) FGFR1c ligand binding and activation | 9.0e-01 | 8.1e-01 | 9.2e-01 | 9.0e-01 | 4.8e-01 | 7.5e-01 |
| 507 | (REACTOME) Metabolism of folate and pterines | 9.0e-01 | 6.3e-01 | 9.4e-01 | 7.8e-01 | 3.2e-01 | 9.0e-01 |
| 592 | (REACTOME) Thyroxine biosynthesis | 9.0e-01 | 9.9e-01 | 9.9e-01 | 8.5e-01 | 7.8e-01 | 6.2e-01 |
| 599 | (REACTOME) PECAM1 interactions | 9.0e-01 | 5.7e-01 | 9.7e-01 | 8.5e-01 | 8.2e-01 | 2.4e-01 |
| 679 | (REACTOME) The phototransduction cascade | 9.0e-01 | 9.6e-01 | 8.7e-01 | 9.1e-01 | 9.6e-01 | 6.6e-01 |
| 922 | (REACTOME) Trafficking of GluR2-containing AMPA receptors | 9.0e-01 | 9.4e-01 | 8.3e-01 | 9.5e-01 | 4.0e-01 | 7.2e-01 |
| 938 | (REACTOME) Tight junction interactions | 9.0e-01 | 9.4e-01 | 6.0e-01 | 9.6e-01 | 4.2e-01 | 8.4e-01 |
| 984 | (REACTOME) Post NMDA receptor activation events | 9.0e-01 | 9.9e-01 | 8.3e-01 | 9.4e-01 | 3.4e-01 | 5.6e-01 |
| 1269 | (REACTOME) Melanin biosynthesis | 9.0e-01 | 9.2e-01 | 9.6e-01 | 1.0e+00 | NA | NA |
| 1434 | (REACTOME) Polymerase switching | 9.0e-01 | 6.1e-01 | 8.2e-01 | 8.3e-01 | 6.5e-01 | 9.4e-01 |
| 1435 | (REACTOME) Leading Strand Synthesis | 9.0e-01 | 6.1e-01 | 8.2e-01 | 8.3e-01 | 6.5e-01 | 9.4e-01 |
| 1474 | (REACTOME) Galactose catabolism | 9.0e-01 | 8.2e-01 | 8.6e-01 | 8.8e-01 | 7.6e-01 | 1.0e-01 |
| 1569 | (REACTOME) Platelet Aggregation (Plug Formation) | 9.0e-01 | 7.3e-01 | 6.0e-01 | 9.5e-01 | 8.9e-01 | 6.4e-01 |
| 1695 | (REACTOME) RUNX3 regulates NOTCH signaling | 9.0e-01 | 4.6e-01 | 9.4e-01 | 9.6e-01 | 9.6e-01 | 4.4e-01 |
| 1783 | (REACTOME) RAC1 GTPase cycle | 9.0e-01 | 0.0e+00 | 6.2e-01 | 8.5e-01 | 1.7e-01 | 1.0e-02 |
| 1926 | (REACTOME) Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 9.0e-01 | 7.2e-01 | 8.9e-01 | 8.9e-01 | 9.4e-01 | 8.1e-01 |
| 2007 | (REACTOME) Defective F9 activation | 9.0e-01 | 8.1e-01 | 9.7e-01 | 9.7e-01 | 9.2e-01 | 4.1e-01 |
| 177 | (REACTOME) Synthesis of PE | 9.0e-01 | 9.5e-01 | 6.0e-01 | 4.8e-01 | 9.2e-01 | 7.3e-01 |
| 440 | (REACTOME) Signalling to p38 via RIT and RIN | 9.0e-01 | 7.6e-01 | 8.6e-01 | 9.4e-01 | 8.5e-01 | 1.0e+00 |
| 1113 | (REACTOME) GSD II | 9.0e-01 | 6.9e-01 | 6.0e-01 | 8.5e-01 | 8.7e-01 | 6.0e-01 |
| 1263 | (REACTOME) MTF1 activates gene expression | 9.0e-01 | 9.2e-01 | 9.1e-01 | 9.5e-01 | 8.9e-01 | 5.5e-01 |
| 1264 | (REACTOME) Response to metal ions | 9.0e-01 | 9.2e-01 | 9.1e-01 | 9.5e-01 | 8.9e-01 | 5.5e-01 |
| 1612 | (REACTOME) PTK6 Down-Regulation | 9.0e-01 | 9.5e-01 | 6.6e-01 | 9.2e-01 | 5.1e-01 | 4.7e-01 |
| 1413 | (REACTOME) Intra-Golgi and retrograde Golgi-to-ER traffic | 9.0e-01 | 9.0e-01 | 9.9e-01 | 8.4e-01 | 7.8e-01 | 8.2e-01 |
| 417 | (REACTOME) Nef Mediated CD8 Down-regulation | 9.0e-01 | 8.0e-01 | 9.5e-01 | 9.1e-01 | 5.9e-01 | 1.0e+00 |
| 466 | (REACTOME) Cholesterol biosynthesis | 9.0e-01 | 3.3e-01 | 5.2e-01 | 9.5e-01 | 7.9e-01 | 1.0e+00 |
| 1411 | (REACTOME) Intra-Golgi traffic | 9.0e-01 | 5.7e-01 | 8.4e-01 | 9.1e-01 | 8.1e-01 | 7.1e-01 |
| 589 | (REACTOME) Catecholamine biosynthesis | 9.0e-01 | 9.4e-01 | 6.4e-01 | 8.4e-01 | 9.7e-01 | 6.5e-01 |
| 1650 | (REACTOME) rRNA processing in the mitochondrion | 9.1e-01 | 8.6e-01 | 6.0e-01 | 9.2e-01 | 4.5e-01 | 6.3e-01 |
| 1490 | (REACTOME) mRNA Capping | 9.1e-01 | 5.3e-01 | 1.0e+00 | 8.9e-01 | 3.0e-01 | 3.5e-01 |
| 253 | (REACTOME) Gamma carboxylation, hypusine formation and arylsulfatase activation | 9.1e-01 | 9.1e-01 | 8.6e-01 | 9.5e-01 | 7.0e-01 | 8.3e-01 |
| 296 | (REACTOME) HIV Transcription Initiation | 9.1e-01 | 4.1e-01 | 9.7e-01 | 9.1e-01 | 3.2e-01 | 3.5e-01 |
| 297 | (REACTOME) RNA Polymerase II HIV Promoter Escape | 9.1e-01 | 4.1e-01 | 9.7e-01 | 9.1e-01 | 3.2e-01 | 3.5e-01 |
| 319 | (REACTOME) Virus Assembly and Release | 9.1e-01 | 9.9e-01 | 9.6e-01 | 9.0e-01 | 8.2e-01 | 7.8e-01 |
| 332 | (REACTOME) Assembly of Viral Components at the Budding Site | 9.1e-01 | 9.9e-01 | 9.6e-01 | 9.0e-01 | 8.2e-01 | 7.8e-01 |
| 380 | (REACTOME) Integration of viral DNA into host genomic DNA | 9.1e-01 | 9.7e-01 | 9.6e-01 | 8.5e-01 | 8.1e-01 | 9.1e-01 |
| 395 | (REACTOME) Autointegration results in viral DNA circles | 9.1e-01 | 9.7e-01 | 9.6e-01 | 8.5e-01 | 8.1e-01 | 9.1e-01 |
| 431 | (REACTOME) Regulation of beta-cell development | 9.1e-01 | 4.6e-01 | 9.4e-01 | 9.4e-01 | 8.6e-01 | 2.0e-02 |
| 486 | (REACTOME) Synthesis of bile acids and bile salts via 24-hydroxycholesterol | 9.1e-01 | 9.1e-01 | 8.2e-01 | 7.8e-01 | 8.0e-01 | 6.4e-01 |
| 587 | (REACTOME) Metabolism of amine-derived hormones | 9.1e-01 | 7.6e-01 | 7.3e-01 | 9.1e-01 | 3.3e-01 | 8.8e-01 |
| 606 | (REACTOME) Stimulation of the cell death response by PAK-2p34 | 9.1e-01 | 8.1e-01 | 1.0e+00 | 8.3e-01 | 9.4e-01 | 3.3e-01 |
| 656 | (REACTOME) Condensation of Prophase Chromosomes | 9.1e-01 | 6.7e-01 | 6.1e-01 | 9.8e-01 | 6.5e-01 | 7.9e-01 |
| 740 | (REACTOME) PKMTs methylate histone lysines | 9.1e-01 | 5.6e-01 | 8.8e-01 | 9.9e-01 | 4.9e-01 | 1.0e+00 |
| 747 | (REACTOME) SUMOylation of ubiquitinylation proteins | 9.1e-01 | 6.2e-01 | 8.3e-01 | 9.2e-01 | 8.3e-01 | 2.7e-01 |
| 945 | (REACTOME) Axon guidance | 9.1e-01 | 3.3e-01 | 6.9e-01 | 1.0e+00 | 8.4e-01 | 5.1e-01 |
| 1010 | (REACTOME) Synthesis of UDP-N-acetyl-glucosamine | 9.1e-01 | 9.3e-01 | 8.3e-01 | 8.2e-01 | 9.6e-01 | 4.6e-01 |
| 1035 | (REACTOME) KSRP (KHSRP) binds and destabilizes mRNA | 9.1e-01 | 7.2e-01 | 9.4e-01 | 9.9e-01 | 9.4e-01 | 3.3e-01 |
| 1036 | (REACTOME) Ionotropic activity of kainate receptors | 9.1e-01 | 9.2e-01 | 9.9e-01 | 9.4e-01 | 2.8e-01 | 7.6e-01 |
| 1038 | (REACTOME) Activation of Ca-permeable Kainate Receptor | 9.1e-01 | 9.2e-01 | 9.9e-01 | 9.4e-01 | 2.8e-01 | 7.6e-01 |
| 1041 | (REACTOME) Transcriptional regulation of pluripotent stem cells | 9.1e-01 | 6.9e-01 | 6.4e-01 | 7.9e-01 | 3.3e-01 | 4.0e-01 |
| 1046 | (REACTOME) Thrombin signalling through proteinase activated receptors (PARs) | 9.1e-01 | 8.5e-01 | 9.7e-01 | 9.6e-01 | 8.2e-01 | 3.7e-01 |
| 1091 | (REACTOME) VEGFR2 mediated vascular permeability | 9.1e-01 | 2.1e-01 | 5.3e-01 | 1.0e+00 | 6.8e-01 | 8.4e-01 |
| 1104 | (REACTOME) Toxicity of botulinum toxin type E (botE) | 9.1e-01 | 9.1e-01 | 8.7e-01 | 8.5e-01 | 6.8e-01 | 4.4e-01 |
| 1190 | (REACTOME) Pyroptosis | 9.1e-01 | 9.6e-01 | 9.3e-01 | 8.6e-01 | 9.1e-01 | 8.8e-01 |
| 1325 | (REACTOME) Nonhomologous End-Joining (NHEJ) | 9.1e-01 | 2.2e-01 | 6.0e-01 | 7.8e-01 | 8.0e-01 | 2.7e-01 |
| 1409 | (REACTOME) COPI-dependent Golgi-to-ER retrograde traffic | 9.1e-01 | 8.1e-01 | 8.3e-01 | 8.5e-01 | 8.8e-01 | 6.8e-01 |
| 1486 | (REACTOME) Ethanol oxidation | 9.1e-01 | 8.1e-01 | 9.8e-01 | 9.4e-01 | 9.8e-01 | 3.3e-01 |
| 1516 | (REACTOME) RNA Polymerase II Promoter Escape | 9.1e-01 | 4.1e-01 | 9.7e-01 | 9.1e-01 | 3.2e-01 | 3.5e-01 |
| 1517 | (REACTOME) RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 9.1e-01 | 4.1e-01 | 9.7e-01 | 9.1e-01 | 3.2e-01 | 3.5e-01 |
| 1526 | (REACTOME) Chromosome Maintenance | 9.1e-01 | 3.9e-01 | 6.3e-01 | 8.9e-01 | 7.5e-01 | 6.9e-01 |
| 1565 | (REACTOME) RNA Polymerase II Transcription Initiation | 9.1e-01 | 4.1e-01 | 9.7e-01 | 9.1e-01 | 3.2e-01 | 3.5e-01 |
| 1570 | (REACTOME) RNA Polymerase II Transcription Initiation And Promoter Clearance | 9.1e-01 | 4.1e-01 | 9.7e-01 | 9.1e-01 | 3.2e-01 | 3.5e-01 |
| 1659 | (REACTOME) MET receptor recycling | 9.1e-01 | 9.2e-01 | 6.2e-01 | 9.4e-01 | 5.2e-01 | 3.3e-01 |
| 1697 | (REACTOME) Intestinal infectious diseases | 9.1e-01 | 8.8e-01 | 9.0e-01 | 9.4e-01 | 5.2e-01 | 6.5e-01 |
| 1707 | (REACTOME) Processing of SMDT1 | 9.1e-01 | 3.6e-01 | 9.6e-01 | 8.5e-01 | 4.5e-01 | 6.5e-01 |
| 1770 | (REACTOME) Interleukin-38 signaling | 9.1e-01 | 6.3e-01 | 7.8e-01 | 8.5e-01 | 5.6e-01 | 4.9e-01 |
| 1790 | (REACTOME) RHOBTB2 GTPase cycle | 9.1e-01 | 5.1e-01 | 8.1e-01 | 9.0e-01 | 6.8e-01 | 6.9e-01 |
| 1815 | (REACTOME) Biosynthesis of E-series 18(S)-resolvins | 9.1e-01 | 7.3e-01 | 6.0e-01 | 8.0e-01 | 6.6e-01 | 6.8e-01 |
| 1833 | (REACTOME) BDNF activates NTRK2 (TRKB) signaling | 9.1e-01 | 3.4e-01 | 8.5e-01 | 9.9e-01 | 7.9e-01 | 4.9e-01 |
| 1918 | (REACTOME) EGR2 and SOX10-mediated initiation of Schwann cell myelination | 9.1e-01 | 3.8e-01 | 8.3e-01 | 9.4e-01 | 5.1e-01 | 2.0e-02 |
| 2045 | (REACTOME) Defective RIPK1-mediated regulated necrosis | 9.1e-01 | 4.7e-01 | 8.3e-01 | 8.1e-01 | 2.8e-01 | 2.4e-01 |
| 509 | (REACTOME) Coenzyme A biosynthesis | 9.1e-01 | 9.2e-01 | 9.6e-01 | 3.0e-01 | 9.6e-01 | 7.4e-01 |
| 190 | (REACTOME) Cytosolic sulfonation of small molecules | 9.1e-01 | 5.4e-01 | 6.1e-01 | 5.5e-01 | 3.3e-01 | 5.3e-01 |
| 1832 | (REACTOME) LXR-mediated signaling | 9.1e-01 | 8.4e-01 | 5.2e-01 | 8.7e-01 | 3.8e-01 | 4.9e-01 |
| 975 | (REACTOME) Platelet sensitization by LDL | 9.1e-01 | 8.6e-01 | 9.6e-01 | 9.4e-01 | 8.9e-01 | 5.9e-01 |
| 1927 | (REACTOME) Estrogen-stimulated signaling through PRKCZ | 9.1e-01 | 8.1e-01 | 1.0e+00 | 9.4e-01 | 8.9e-01 | 5.3e-01 |
| 1946 | (REACTOME) Diseases of programmed cell death | 9.1e-01 | 6.3e-01 | 9.0e-01 | 9.4e-01 | 7.8e-01 | 2.3e-01 |
| 511 | (REACTOME) Nicotinate metabolism | 9.1e-01 | 7.0e-01 | 8.7e-01 | 7.9e-01 | 9.1e-01 | 3.7e-01 |
| 699 | (REACTOME) Caspase-mediated cleavage of cytoskeletal proteins | 9.1e-01 | 9.2e-01 | 9.9e-01 | 9.1e-01 | 9.7e-01 | 8.0e-01 |
| 1645 | (REACTOME) Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 9.1e-01 | 9.8e-01 | 6.2e-01 | 9.4e-01 | 9.3e-01 | 8.6e-01 |
| 730 | (REACTOME) Scavenging by Class H Receptors | 9.1e-01 | 9.9e-01 | 8.3e-01 | 9.2e-01 | 8.7e-01 | 3.7e-01 |
| 167 | (REACTOME) Acyl chain remodelling of PE | 9.1e-01 | 9.2e-01 | 7.8e-01 | 9.1e-01 | 6.9e-01 | 4.1e-01 |
| 1611 | (REACTOME) PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases | 9.1e-01 | 9.2e-01 | 6.0e-01 | 9.2e-01 | 9.1e-01 | 6.4e-01 |
| 26 | (REACTOME) Formation of apoptosome | 9.1e-01 | 8.8e-01 | 7.1e-01 | 9.4e-01 | 9.9e-01 | 6.6e-01 |
| 1037 | (REACTOME) Activation of Na-permeable kainate receptors | 9.1e-01 | 7.5e-01 | 9.5e-01 | NA | 7.7e-01 | 9.6e-01 |
| 1262 | (REACTOME) FGFRL1 modulation of FGFR1 signaling | 9.1e-01 | 8.6e-01 | 9.9e-01 | 9.1e-01 | 6.9e-01 | 7.9e-01 |
| 1921 | (REACTOME) Regulation of the apoptosome activity | 9.1e-01 | 8.8e-01 | 7.1e-01 | 9.4e-01 | 9.9e-01 | 6.6e-01 |
| 996 | (REACTOME) RSK activation | 9.2e-01 | 8.0e-01 | 9.9e-01 | 9.5e-01 | 9.4e-01 | 1.0e+00 |
| 1862 | (REACTOME) Activated NTRK3 signals through RAS | 9.2e-01 | 9.1e-01 | 8.6e-01 | 9.5e-01 | 9.2e-01 | 7.9e-01 |
| 636 | (REACTOME) Abacavir metabolism | 9.2e-01 | 3.3e-01 | 9.2e-01 | 9.2e-01 | 4.6e-01 | 6.0e-01 |
| 1417 | (REACTOME) Glycerophospholipid catabolism | 9.2e-01 | 8.4e-01 | 9.7e-01 | 9.4e-01 | 8.9e-01 | 2.4e-01 |
| 1514 | (REACTOME) RNA Polymerase I Transcription Initiation | 9.2e-01 | 9.3e-01 | 7.8e-01 | 9.4e-01 | 4.8e-01 | 4.2e-01 |
| 16 | (REACTOME) POLB-Dependent Long Patch Base Excision Repair | 9.2e-01 | 4.7e-01 | 6.3e-01 | 9.4e-01 | 6.1e-01 | 5.0e-01 |
| 95 | (REACTOME) Endosomal/Vacuolar pathway | 9.2e-01 | 8.1e-01 | 9.9e-01 | 8.6e-01 | 9.3e-01 | 4.7e-01 |
| 621 | (REACTOME) Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) | 9.2e-01 | 9.6e-01 | 9.9e-01 | 3.0e-01 | 6.0e-01 | 3.0e-01 |
| 1268 | (REACTOME) Formation of xylulose-5-phosphate | 9.2e-01 | 3.9e-01 | 9.0e-01 | 8.5e-01 | 9.4e-01 | 7.1e-01 |
| 1201 | (REACTOME) TNFR1-mediated ceramide production | 9.2e-01 | 8.3e-01 | 9.7e-01 | 8.9e-01 | 8.2e-01 | 8.5e-01 |
| 1731 | (REACTOME) HDL assembly | 9.2e-01 | 9.1e-01 | 9.6e-01 | 9.8e-01 | 4.1e-01 | 4.0e-01 |
| 487 | (REACTOME) Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 9.2e-01 | 8.1e-01 | 7.3e-01 | 9.4e-01 | 5.7e-01 | 6.0e-01 |
| 1430 | (REACTOME) Activation of the pre-replicative complex | 9.2e-01 | 6.0e-01 | 6.0e-01 | 8.5e-01 | 6.9e-01 | 1.0e+00 |
| 148 | (REACTOME) The citric acid (TCA) cycle and respiratory electron transport | 9.2e-01 | 0.0e+00 | 7.1e-01 | 7.8e-01 | 2.5e-01 | 1.0e-02 |
| 955 | (REACTOME) Cation-coupled Chloride cotransporters | 9.2e-01 | 6.8e-01 | 6.0e-01 | 8.2e-01 | 7.0e-01 | 2.4e-01 |
| 1714 | (REACTOME) RUNX3 regulates BCL2L11 (BIM) transcription | 9.2e-01 | 4.2e-01 | 7.9e-01 | 9.4e-01 | 7.2e-01 | 8.4e-01 |
| 910 | (REACTOME) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | 9.2e-01 | 7.7e-01 | 9.0e-01 | 8.5e-01 | 5.7e-01 | 7.9e-01 |
| 994 | (REACTOME) Activation of NMDA receptors and postsynaptic events | 9.2e-01 | 1.0e+00 | 8.3e-01 | 9.5e-01 | 6.4e-01 | 5.9e-01 |
| 1067 | (REACTOME) Interconversion of nucleotide di- and triphosphates | 9.2e-01 | 4.8e-01 | 8.5e-01 | 9.9e-01 | 9.9e-01 | 8.9e-01 |
| 1482 | (REACTOME) Carnitine synthesis | 9.2e-01 | 7.3e-01 | 7.5e-01 | 8.5e-01 | 4.7e-01 | 2.6e-01 |
| 1683 | (REACTOME) RUNX1 regulates transcription of genes involved in BCR signaling | 9.2e-01 | 7.6e-01 | 9.4e-01 | 9.4e-01 | 7.1e-01 | 9.0e-01 |
| 1422 | (REACTOME) Mitotic Prometaphase | 9.2e-01 | 9.5e-01 | 9.2e-01 | 1.0e+00 | 1.0e+00 | 9.9e-01 |
| 859 | (REACTOME) Costimulation by the CD28 family | 9.2e-01 | 1.8e-01 | 8.7e-01 | 9.9e-01 | 8.4e-01 | 8.0e-01 |
| 537 | (REACTOME) Signaling by BMP | 9.2e-01 | 3.6e-01 | 8.8e-01 | 7.8e-01 | 4.9e-01 | 4.4e-01 |
| 65 | (REACTOME) Effects of PIP2 hydrolysis | 9.2e-01 | 8.3e-01 | 7.3e-01 | 9.1e-01 | 2.8e-01 | 9.4e-01 |
| 635 | (REACTOME) Abacavir ADME | 9.2e-01 | 4.1e-01 | 9.7e-01 | 9.5e-01 | 6.0e-01 | 4.8e-01 |
| 717 | (REACTOME) Peptide hormone metabolism | 9.2e-01 | 8.1e-01 | 8.3e-01 | 9.2e-01 | 6.9e-01 | 6.2e-01 |
| 954 | (REACTOME) Arachidonate production from DAG | 9.2e-01 | 8.3e-01 | 7.3e-01 | 9.1e-01 | 2.8e-01 | 9.4e-01 |
| 1625 | (REACTOME) Transcriptional Regulation by VENTX | 9.2e-01 | 4.3e-01 | 9.2e-01 | 7.8e-01 | 7.2e-01 | 8.5e-01 |
| 393 | (REACTOME) Interactions of Rev with host cellular proteins | 9.3e-01 | 9.4e-01 | 9.2e-01 | 1.0e+00 | 8.9e-01 | 5.6e-01 |
| 192 | (REACTOME) Glucuronidation | 9.3e-01 | 2.9e-01 | 9.4e-01 | 8.3e-01 | 8.8e-01 | 1.7e-01 |
| 1685 | (REACTOME) RUNX1 regulates transcription of genes involved in interleukin signaling | 9.3e-01 | 4.1e-01 | 8.6e-01 | 9.4e-01 | 9.8e-01 | 8.8e-01 |
| 2078 | (REACTOME) RHOBTB3 ATPase cycle | 9.3e-01 | 9.4e-01 | 9.1e-01 | 8.5e-01 | 8.4e-01 | 9.1e-01 |
| 131 | (REACTOME) NR1D1 (REV-ERBA) represses gene expression | 9.3e-01 | 9.0e-01 | 7.1e-01 | 9.1e-01 | 3.7e-01 | 6.6e-01 |
| 449 | (REACTOME) FGFR1 ligand binding and activation | 9.3e-01 | 8.0e-01 | 9.5e-01 | 8.5e-01 | 7.1e-01 | 7.7e-01 |
| 1813 | (REACTOME) Biosynthesis of protectins | 9.3e-01 | 9.3e-01 | 6.0e-01 | 7.8e-01 | 5.7e-01 | 1.0e+00 |
| 1831 | (REACTOME) Biosynthesis of E-series 18(R)-resolvins | 9.3e-01 | 6.8e-01 | 6.0e-01 | 8.0e-01 | 8.9e-01 | 6.2e-01 |
| 18 | (REACTOME) Resolution of AP sites via the single-nucleotide replacement pathway | 9.3e-01 | 4.8e-01 | 9.1e-01 | 9.2e-01 | 2.0e-01 | 4.9e-01 |
| 1627 | (REACTOME) TBC/RABGAPs | 9.3e-01 | 4.8e-01 | 1.0e+00 | 8.5e-01 | 7.9e-01 | 4.1e-01 |
| 265 | (REACTOME) The role of Nef in HIV-1 replication and disease pathogenesis | 9.3e-01 | 6.6e-01 | 1.0e+00 | 1.0e+00 | 7.9e-01 | 4.4e-01 |
| 445 | (REACTOME) Heme degradation | 9.3e-01 | 6.1e-01 | 9.4e-01 | 9.1e-01 | 9.1e-01 | 5.0e-02 |
| 848 | (REACTOME) Olfactory Signaling Pathway | 9.3e-01 | 7.9e-01 | 9.0e-01 | 9.5e-01 | 4.7e-01 | 8.4e-01 |
| 919 | (REACTOME) Sema4D mediated inhibition of cell attachment and migration | 9.3e-01 | 9.6e-01 | 9.4e-01 | 9.2e-01 | 7.4e-01 | 7.1e-01 |
| 612 | (REACTOME) Epigenetic regulation of gene expression | 9.3e-01 | 9.5e-01 | 7.5e-01 | 9.8e-01 | 3.4e-01 | 3.7e-01 |
| 5 | (REACTOME) PKB-mediated events | 9.3e-01 | 5.6e-01 | 6.0e-01 | 8.7e-01 | 6.1e-01 | 9.4e-01 |
| 270 | (REACTOME) PDE3B signalling | 9.3e-01 | 5.6e-01 | 6.0e-01 | 8.7e-01 | 6.1e-01 | 9.4e-01 |
| 932 | (REACTOME) Netrin mediated repulsion signals | 9.3e-01 | 9.0e-01 | 8.3e-01 | 9.8e-01 | 5.7e-01 | 8.0e-01 |
| 33 | (REACTOME) Apoptotic factor-mediated response | 9.3e-01 | 9.9e-01 | 7.8e-01 | 9.9e-01 | 9.8e-01 | 7.9e-01 |
| 1095 | (REACTOME) B-WICH complex positively regulates rRNA expression | 9.3e-01 | 9.4e-01 | 6.0e-01 | 8.5e-01 | 5.4e-01 | 5.3e-01 |
| 223 | (REACTOME) Uncoating of the HIV Virion | 9.3e-01 | 9.9e-01 | 9.1e-01 | 9.6e-01 | 7.7e-01 | 2.6e-01 |
| 226 | (REACTOME) Reverse Transcription of HIV RNA | 9.3e-01 | 9.9e-01 | 9.1e-01 | 9.6e-01 | 7.7e-01 | 2.6e-01 |
| 258 | (REACTOME) Minus-strand DNA synthesis | 9.3e-01 | 9.9e-01 | 9.1e-01 | 9.6e-01 | 7.7e-01 | 2.6e-01 |
| 259 | (REACTOME) Plus-strand DNA synthesis | 9.3e-01 | 9.9e-01 | 9.1e-01 | 9.6e-01 | 7.7e-01 | 2.6e-01 |
| 836 | (REACTOME) Energy dependent regulation of mTOR by LKB1-AMPK | 9.3e-01 | 9.0e-01 | 6.0e-01 | 9.4e-01 | 9.5e-01 | 1.9e-01 |
| 1840 | (REACTOME) Activated NTRK2 signals through PLCG1 | 9.3e-01 | 3.4e-01 | 9.0e-01 | 1.0e+00 | 5.4e-01 | 4.4e-01 |
| 2014 | (REACTOME) Nervous system development | 9.3e-01 | 4.0e-01 | 6.5e-01 | 1.0e+00 | 7.8e-01 | 2.2e-01 |
| 74 | (REACTOME) Prolactin receptor signaling | 9.3e-01 | 5.4e-01 | 8.6e-01 | 9.4e-01 | 7.8e-01 | 1.3e-01 |
| 1543 | (REACTOME) IRS activation | 9.4e-01 | 7.2e-01 | 8.5e-01 | 9.4e-01 | 2.7e-01 | 4.5e-01 |
| 390 | (REACTOME) Unwinding of DNA | 9.4e-01 | 7.5e-01 | 8.5e-01 | 9.5e-01 | 7.8e-01 | 9.0e-01 |
| 1202 | (REACTOME) RHO GTPases regulate CFTR trafficking | 9.4e-01 | 5.6e-01 | 7.1e-01 | 1.0e+00 | 6.9e-01 | 6.5e-01 |
| 434 | (REACTOME) Activation of TRKA receptors | 9.4e-01 | 9.2e-01 | 8.5e-01 | 8.5e-01 | 6.1e-01 | 1.0e+00 |
| 43 | (REACTOME) PLC beta mediated events | 9.4e-01 | 5.7e-01 | 9.8e-01 | 9.4e-01 | 8.9e-01 | 4.3e-01 |
| 290 | (REACTOME) PLC-gamma1 signalling | 9.4e-01 | 9.6e-01 | 8.9e-01 | 9.6e-01 | 6.2e-01 | 6.6e-01 |
| 1039 | (REACTOME) Activation of kainate receptors upon glutamate binding | 9.4e-01 | 8.8e-01 | 1.0e+00 | 9.9e-01 | 3.0e-01 | 4.9e-01 |
| 1427 | (REACTOME) G2 Phase | 9.4e-01 | 6.8e-01 | 9.9e-01 | 9.6e-01 | 6.5e-01 | 8.4e-01 |
| 443 | (REACTOME) Porphyrin metabolism | 9.4e-01 | 9.1e-01 | 9.4e-01 | 9.6e-01 | 9.6e-01 | 4.8e-01 |
| 909 | (REACTOME) Incretin synthesis, secretion, and inactivation | 9.4e-01 | 7.5e-01 | 6.4e-01 | 8.5e-01 | 8.5e-01 | 8.0e-01 |
| 1623 | (REACTOME) Lysosomal oligosaccharide catabolism | 9.4e-01 | 5.6e-01 | 6.7e-01 | 8.7e-01 | 9.1e-01 | 6.4e-01 |
| 1736 | (REACTOME) Chylomicron clearance | 9.4e-01 | 8.0e-01 | 7.3e-01 | 9.5e-01 | 8.0e-01 | 9.5e-01 |
| 1362 | (REACTOME) GDP-fucose biosynthesis | 9.4e-01 | 9.9e-01 | 9.6e-01 | 9.5e-01 | 7.8e-01 | 9.4e-01 |
| 238 | (REACTOME) Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | 9.4e-01 | 3.0e-02 | 7.3e-01 | 7.8e-01 | 2.8e-01 | 2.0e-02 |
| 523 | (REACTOME) AKT phosphorylates targets in the nucleus | 9.4e-01 | 5.0e-01 | 9.2e-01 | 8.5e-01 | 3.5e-01 | 7.0e-02 |
| 668 | (REACTOME) The canonical retinoid cycle in rods (twilight vision) | 9.4e-01 | 6.8e-01 | 8.6e-01 | 9.6e-01 | 9.2e-01 | 3.6e-01 |
| 972 | (REACTOME) GP1b-IX-V activation signalling | 9.4e-01 | 9.7e-01 | 8.0e-01 | 9.4e-01 | 9.3e-01 | 8.0e-01 |
| 1047 | (REACTOME) SUMOylation of RNA binding proteins | 9.4e-01 | 9.1e-01 | 8.0e-01 | 9.5e-01 | 9.4e-01 | 4.8e-01 |
| 1052 | (REACTOME) Disassembly of the destruction complex and recruitment of AXIN to the membrane | 9.4e-01 | 6.5e-01 | 8.3e-01 | 9.6e-01 | 8.7e-01 | 1.0e+00 |
| 1213 | (REACTOME) Constitutive Signaling by EGFRvIII | 9.4e-01 | 7.8e-01 | 8.7e-01 | 9.2e-01 | 9.2e-01 | 4.7e-01 |
| 1214 | (REACTOME) Signaling by EGFRvIII in Cancer | 9.4e-01 | 7.8e-01 | 8.7e-01 | 9.2e-01 | 9.2e-01 | 4.7e-01 |
| 1519 | (REACTOME) Purine ribonucleoside monophosphate biosynthesis | 9.4e-01 | 9.2e-01 | 8.3e-01 | 8.5e-01 | 5.7e-01 | 5.3e-01 |
| 1631 | (REACTOME) Golgi-to-ER retrograde transport | 9.4e-01 | 7.9e-01 | 8.7e-01 | 8.4e-01 | 8.5e-01 | 6.7e-01 |
| 1784 | (REACTOME) RAC2 GTPase cycle | 9.4e-01 | 8.0e-02 | 8.3e-01 | 9.4e-01 | 4.2e-01 | 2.5e-01 |
| 2037 | (REACTOME) Microbial modulation of RIPK1-mediated regulated necrosis | 9.4e-01 | 5.0e-01 | 9.1e-01 | 8.5e-01 | 6.0e-01 | 4.2e-01 |
| 1836 | (REACTOME) Biosynthesis of DPAn-3-derived protectins and resolvins | 9.4e-01 | 4.3e-01 | 9.6e-01 | 9.6e-01 | 6.2e-01 | 6.3e-01 |
| 58 | (REACTOME) SOS-mediated signalling | 9.4e-01 | 8.7e-01 | 8.3e-01 | 9.5e-01 | 1.4e-01 | 7.6e-01 |
| 1294 | (REACTOME) Defective ABCA1 causes TGD | 9.4e-01 | 4.3e-01 | 9.7e-01 | 9.4e-01 | 3.5e-01 | 1.5e-01 |
| 657 | (REACTOME) Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 9.4e-01 | 8.3e-01 | 9.4e-01 | 9.9e-01 | 5.6e-01 | 7.4e-01 |
| 863 | (REACTOME) CD28 dependent Vav1 pathway | 9.4e-01 | 5.3e-01 | 6.9e-01 | 9.2e-01 | 9.7e-01 | 4.2e-01 |
| 899 | (REACTOME) Trafficking of AMPA receptors | 9.4e-01 | 8.1e-01 | 9.0e-01 | 9.4e-01 | 5.1e-01 | 8.4e-01 |
| 900 | (REACTOME) Glutamate binding, activation of AMPA receptors and synaptic plasticity | 9.4e-01 | 8.1e-01 | 9.0e-01 | 9.4e-01 | 5.1e-01 | 8.4e-01 |
| 1007 | (REACTOME) Synthesis of Dolichyl-phosphate | 9.4e-01 | 4.4e-01 | 9.9e-01 | 8.3e-01 | 3.4e-01 | 5.5e-01 |
| 1640 | (REACTOME) Reelin signalling pathway | 9.4e-01 | 6.4e-01 | 9.5e-01 | 9.0e-01 | 9.7e-01 | 2.4e-01 |
| 1665 | (REACTOME) Protein methylation | 9.4e-01 | 4.8e-01 | 9.2e-01 | 9.2e-01 | 6.5e-01 | 7.9e-01 |
| 1788 | (REACTOME) RHOG GTPase cycle | 9.4e-01 | 1.4e-01 | 7.1e-01 | 8.8e-01 | 6.2e-01 | 7.4e-01 |
| 2105 | (REACTOME) Drug-mediated inhibition of MET activation | 9.4e-01 | 9.2e-01 | 9.7e-01 | 9.0e-01 | 5.1e-01 | 4.3e-01 |
| 1436 | (REACTOME) Removal of the Flap Intermediate | 9.4e-01 | 8.1e-01 | 7.9e-01 | 8.6e-01 | 4.9e-01 | 1.0e+00 |
| 1437 | (REACTOME) Processive synthesis on the lagging strand | 9.4e-01 | 8.1e-01 | 7.9e-01 | 8.6e-01 | 4.9e-01 | 1.0e+00 |
| 307 | (REACTOME) Nef Mediated CD4 Down-regulation | 9.4e-01 | 4.4e-01 | 1.0e+00 | 9.2e-01 | 7.5e-01 | 7.5e-01 |
| 435 | (REACTOME) NGF-independant TRKA activation | 9.4e-01 | 9.2e-01 | 7.8e-01 | 8.2e-01 | 4.7e-01 | 1.0e+00 |
| 1580 | (REACTOME) mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 9.4e-01 | 6.9e-01 | 7.8e-01 | 8.6e-01 | 6.1e-01 | 5.6e-01 |
| 1652 | (REACTOME) TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation | 9.5e-01 | 1.6e-01 | 7.4e-01 | 8.5e-01 | 9.8e-01 | 5.7e-01 |
| 130 | (REACTOME) Mitochondrial iron-sulfur cluster biogenesis | 9.5e-01 | 4.6e-01 | 9.4e-01 | 9.4e-01 | 6.9e-01 | 4.6e-01 |
| 1087 | (REACTOME) Uptake and function of anthrax toxins | 9.5e-01 | 9.1e-01 | 9.7e-01 | 9.4e-01 | 8.4e-01 | 6.8e-01 |
| 690 | (REACTOME) Cytosolic iron-sulfur cluster assembly | 9.5e-01 | 9.3e-01 | 6.0e-01 | 8.5e-01 | 7.8e-01 | 3.3e-01 |
| 455 | (REACTOME) FGFR1c and Klotho ligand binding and activation | 9.5e-01 | 9.6e-01 | 7.1e-01 | 9.1e-01 | 6.8e-01 | 7.0e-01 |
| 231 | (REACTOME) Synthesis of dolichyl-phosphate mannose | 9.5e-01 | 8.3e-01 | 9.6e-01 | 9.4e-01 | 6.1e-01 | 5.1e-01 |
| 244 | (REACTOME) Triglyceride catabolism | 9.5e-01 | 8.0e-01 | 9.6e-01 | 8.5e-01 | 6.1e-01 | 6.6e-01 |
| 718 | (REACTOME) Nuclear Envelope Breakdown | 9.5e-01 | 8.4e-01 | 9.6e-01 | 9.5e-01 | 8.4e-01 | 1.3e-01 |
| 1056 | (REACTOME) Defective DPM1 causes CDG-1e | 9.5e-01 | 8.3e-01 | 9.6e-01 | 9.4e-01 | 6.1e-01 | 5.1e-01 |
| 1057 | (REACTOME) Defective DPM3 causes CDG-1o | 9.5e-01 | 8.3e-01 | 9.6e-01 | 9.4e-01 | 6.1e-01 | 5.1e-01 |
| 1058 | (REACTOME) Defective DPM2 causes CDG-1u | 9.5e-01 | 8.3e-01 | 9.6e-01 | 9.4e-01 | 6.1e-01 | 5.1e-01 |
| 1412 | (REACTOME) Retrograde transport at the Trans-Golgi-Network | 9.5e-01 | 7.7e-01 | 8.0e-01 | 9.4e-01 | 9.8e-01 | 7.3e-01 |
| 183 | (REACTOME) DAG and IP3 signaling | 9.5e-01 | 8.4e-01 | 9.6e-01 | 9.1e-01 | 8.5e-01 | 6.0e-01 |
| 1229 | (REACTOME) SHC-mediated cascade:FGFR1 | 9.5e-01 | 7.3e-01 | 8.5e-01 | 9.6e-01 | 7.1e-01 | 5.5e-01 |
| 101 | (REACTOME) PI3K events in ERBB4 signaling | 9.5e-01 | 8.5e-01 | 6.0e-01 | 9.0e-01 | 8.0e-01 | 5.8e-01 |
| 47 | (REACTOME) Presynaptic depolarization and calcium channel opening | 9.5e-01 | 9.6e-01 | 9.6e-01 | 9.6e-01 | 5.6e-01 | 8.6e-01 |
| 983 | (REACTOME) Recycling pathway of L1 | 9.5e-01 | 9.8e-01 | 9.4e-01 | 1.0e+00 | 9.9e-01 | 1.9e-01 |
| 1307 | (REACTOME) Diseases associated with surfactant metabolism | 9.5e-01 | 6.0e-01 | 6.3e-01 | 9.8e-01 | 2.6e-01 | 6.1e-01 |
| 1309 | (REACTOME) Defective CSF2RB causes SMDP5 | 9.5e-01 | 6.0e-01 | 6.3e-01 | 9.8e-01 | 2.6e-01 | 6.1e-01 |
| 1310 | (REACTOME) Defective CSF2RA causes SMDP4 | 9.5e-01 | 6.0e-01 | 6.3e-01 | 9.8e-01 | 2.6e-01 | 6.1e-01 |
| 959 | (REACTOME) Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) | 9.5e-01 | 1.0e+00 | 7.6e-01 | 8.0e-01 | 8.5e-01 | 9.4e-01 |
| 444 | (REACTOME) Heme biosynthesis | 9.6e-01 | 4.7e-01 | 9.3e-01 | 9.3e-01 | 9.9e-01 | 2.8e-01 |
| 1577 | (REACTOME) Synthesis of Ketone Bodies | 9.6e-01 | 5.6e-01 | 8.3e-01 | 9.1e-01 | 4.3e-01 | 8.2e-01 |
| 28 | (REACTOME) Cytochrome c-mediated apoptotic response | 9.6e-01 | 9.4e-01 | 7.8e-01 | 9.5e-01 | 9.4e-01 | 8.4e-01 |
| 865 | (REACTOME) CTLA4 inhibitory signaling | 9.6e-01 | 6.3e-01 | 9.0e-01 | 9.4e-01 | 8.3e-01 | 6.9e-01 |
| 957 | (REACTOME) Post-transcriptional silencing by small RNAs | 9.6e-01 | 3.8e-01 | 1.0e+00 | 9.9e-01 | 8.9e-01 | 9.9e-01 |
| 1763 | (REACTOME) Signaling by Erythropoietin | 9.6e-01 | 6.6e-01 | 8.6e-01 | 9.9e-01 | 1.8e-01 | 8.0e-01 |
| 6 | (REACTOME) PI3K Cascade | 9.6e-01 | 8.1e-01 | 9.0e-01 | 1.0e+00 | 6.0e-01 | 7.5e-01 |
| 638 | (REACTOME) Scavenging of heme from plasma | 9.6e-01 | 1.0e+00 | 9.7e-01 | 9.7e-01 | 7.7e-01 | 4.9e-01 |
| 849 | (REACTOME) Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 9.6e-01 | 6.8e-01 | 6.4e-01 | 8.5e-01 | 8.5e-01 | 8.6e-01 |
| 171 | (REACTOME) Hydrolysis of LPC | 9.6e-01 | 9.2e-01 | 8.7e-01 | 9.4e-01 | 6.4e-01 | 6.8e-01 |
| 242 | (REACTOME) PKA-mediated phosphorylation of key metabolic factors | 9.6e-01 | 3.3e-01 | 9.6e-01 | 9.4e-01 | 1.0e+00 | 5.6e-01 |
| 1224 | (REACTOME) Phospholipase C-mediated cascade: FGFR1 | 9.6e-01 | 8.0e-01 | 9.9e-01 | 9.0e-01 | 8.6e-01 | 8.5e-01 |
| 1634 | (REACTOME) PTK6 promotes HIF1A stabilization | 9.6e-01 | 5.6e-01 | 9.7e-01 | 9.3e-01 | 6.3e-01 | 3.8e-01 |
| 1686 | (REACTOME) RUNX1 regulates transcription of genes involved in WNT signaling | 9.6e-01 | 3.5e-01 | 8.5e-01 | 9.0e-01 | 5.4e-01 | 6.8e-01 |
| 1699 | (REACTOME) Regulation of PTEN gene transcription | 9.6e-01 | 5.1e-01 | 6.0e-01 | 8.5e-01 | 4.5e-01 | 8.6e-01 |
| 1357 | (REACTOME) tRNA processing in the nucleus | 9.6e-01 | 9.4e-01 | 8.6e-01 | 1.0e+00 | 6.3e-01 | 2.1e-01 |
| 1602 | (REACTOME) Gastrin-CREB signalling pathway via PKC and MAPK | 9.6e-01 | 9.0e-01 | 9.6e-01 | 9.5e-01 | 9.9e-01 | 6.9e-01 |
| 1406 | (REACTOME) RNA polymerase II transcribes snRNA genes | 9.6e-01 | 8.1e-01 | 9.0e-01 | 9.3e-01 | 4.6e-01 | 9.4e-01 |
| 825 | (REACTOME) Cytosolic tRNA aminoacylation | 9.6e-01 | 6.9e-01 | 8.8e-01 | 9.4e-01 | 6.6e-01 | 8.4e-01 |
| 169 | (REACTOME) Acyl chain remodelling of PI | 9.7e-01 | 4.9e-01 | 6.0e-01 | 8.5e-01 | 9.8e-01 | 2.4e-01 |
| 631 | (REACTOME) Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 9.7e-01 | 9.8e-01 | 8.3e-01 | 8.5e-01 | 3.5e-01 | 1.0e-02 |
| 790 | (REACTOME) Defective CHST14 causes EDS, musculocontractural type | 9.7e-01 | 8.3e-01 | 8.3e-01 | 7.8e-01 | 4.5e-01 | 1.1e-01 |
| 1748 | (REACTOME) Metabolism of cofactors | 9.7e-01 | 5.1e-01 | 9.1e-01 | 1.0e+00 | 7.8e-01 | 7.6e-01 |
| 1545 | (REACTOME) Insulin receptor signalling cascade | 9.7e-01 | 8.3e-01 | 9.7e-01 | 9.7e-01 | 5.7e-01 | 6.8e-01 |
| 1123 | (REACTOME) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 9.7e-01 | 9.6e-01 | 6.0e-01 | 9.4e-01 | 5.5e-01 | 1.0e+00 |
| 1830 | (REACTOME) MECP2 regulates transcription of genes involved in GABA signaling | 9.7e-01 | 9.6e-01 | 9.8e-01 | 9.5e-01 | 5.4e-01 | 9.9e-01 |
| 737 | (REACTOME) LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 9.7e-01 | 7.7e-01 | 9.4e-01 | 1.3e-01 | 8.4e-01 | 7.3e-01 |
| 1789 | (REACTOME) RHOJ GTPase cycle | 9.7e-01 | 5.0e-02 | 8.3e-01 | 8.5e-01 | 6.3e-01 | 7.7e-01 |
| 55 | (REACTOME) IRS-mediated signalling | 9.7e-01 | 9.1e-01 | 9.1e-01 | 9.9e-01 | 5.9e-01 | 5.6e-01 |
| 1371 | (REACTOME) Choline catabolism | 9.7e-01 | 8.6e-01 | 8.3e-01 | 7.9e-01 | 9.1e-01 | 4.9e-01 |
| 261 | (REACTOME) Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | 9.7e-01 | 7.4e-01 | 1.0e+00 | 9.9e-01 | 6.9e-01 | 8.6e-01 |
| 993 | (REACTOME) CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 9.7e-01 | 9.5e-01 | 9.8e-01 | 1.0e+00 | 4.3e-01 | 7.6e-01 |
| 1856 | (REACTOME) TYSND1 cleaves peroxisomal proteins | 9.7e-01 | 9.9e-01 | 9.6e-01 | 9.1e-01 | 7.8e-01 | 7.9e-01 |
| 1909 | (REACTOME) FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 9.7e-01 | 9.4e-01 | 9.6e-01 | 8.5e-01 | 7.2e-01 | 2.0e-02 |
| 1231 | (REACTOME) FRS-mediated FGFR1 signaling | 9.8e-01 | 8.1e-01 | 8.5e-01 | 9.6e-01 | 5.2e-01 | 5.1e-01 |
| 1138 | (REACTOME) Mitochondrial translation termination | 9.8e-01 | 2.0e-02 | 6.0e-01 | 8.5e-01 | 2.1e-01 | 0.0e+00 |
| 1845 | (REACTOME) Activated NTRK2 signals through PI3K | 9.8e-01 | 2.6e-01 | 8.3e-01 | 9.4e-01 | 7.5e-01 | 6.2e-01 |
| 1805 | (REACTOME) Interleukin-36 pathway | 9.8e-01 | 7.6e-01 | 7.0e-01 | 9.4e-01 | 3.9e-01 | 7.1e-01 |
| 408 | (REACTOME) Nuclear import of Rev protein | 9.8e-01 | 9.7e-01 | 8.7e-01 | 1.0e+00 | 9.4e-01 | 1.7e-01 |
| 123 | (REACTOME) Sperm Motility And Taxes | 9.8e-01 | 9.7e-01 | 9.8e-01 | 7.8e-01 | 5.0e-01 | 9.0e-01 |
| 164 | (REACTOME) Acyl chain remodelling of PC | 9.8e-01 | 6.5e-01 | 6.0e-01 | 9.2e-01 | 8.3e-01 | 3.6e-01 |
| 625 | (REACTOME) Synthesis of 12-eicosatetraenoic acid derivatives | 9.8e-01 | 9.5e-01 | 5.4e-01 | 9.4e-01 | 5.1e-01 | 6.6e-01 |
| 628 | (REACTOME) Ubiquinol biosynthesis | 9.8e-01 | 5.1e-01 | 8.3e-01 | 9.3e-01 | 7.9e-01 | 1.9e-01 |
| 1045 | (REACTOME) SUMOylation of chromatin organization proteins | 9.8e-01 | 9.2e-01 | 9.6e-01 | 9.6e-01 | 9.1e-01 | 2.7e-01 |
| 1094 | (REACTOME) Positive epigenetic regulation of rRNA expression | 9.8e-01 | 9.4e-01 | 7.5e-01 | 9.8e-01 | 6.9e-01 | 5.9e-01 |
| 1236 | (REACTOME) SHC-mediated cascade:FGFR3 | 9.8e-01 | 8.4e-01 | 9.5e-01 | 9.3e-01 | 3.3e-01 | 5.1e-01 |
| 325 | (REACTOME) NS1 Mediated Effects on Host Pathways | 9.8e-01 | 8.1e-01 | 9.2e-01 | 9.4e-01 | 7.9e-01 | 1.5e-01 |
| 411 | (REACTOME) Vpr-mediated nuclear import of PICs | 9.8e-01 | 7.9e-01 | 9.0e-01 | 9.9e-01 | 8.8e-01 | 2.4e-01 |
| 446 | (REACTOME) Signaling by FGFR | 9.8e-01 | 7.7e-01 | 7.9e-01 | 9.4e-01 | 4.5e-01 | 5.5e-01 |
| 1049 | (REACTOME) SUMOylation of DNA replication proteins | 9.8e-01 | 9.9e-01 | 7.6e-01 | 9.4e-01 | 8.4e-01 | 1.4e-01 |
| 1591 | (REACTOME) Processing of Intronless Pre-mRNAs | 9.8e-01 | 7.3e-01 | 8.5e-01 | 9.5e-01 | 6.9e-01 | 6.9e-01 |
| 356 | (REACTOME) Telomere Extension By Telomerase | 9.8e-01 | 4.7e-01 | 8.5e-01 | 1.0e+00 | 9.7e-01 | 7.2e-01 |
| 245 | (REACTOME) PKA activation | 9.8e-01 | 8.1e-01 | 9.3e-01 | 9.4e-01 | 8.6e-01 | 7.0e-01 |
| 1809 | (REACTOME) Biosynthesis of D-series resolvins | 9.8e-01 | 7.0e-01 | 6.0e-01 | 7.9e-01 | 6.4e-01 | 4.8e-01 |
| 1386 | (REACTOME) FGFR2 alternative splicing | 9.8e-01 | 3.8e-01 | 6.1e-01 | 9.2e-01 | 3.4e-01 | 5.1e-01 |
| 1198 | (REACTOME) RHO GTPases activate CIT | 9.8e-01 | 6.3e-01 | 6.2e-01 | 9.4e-01 | 7.5e-01 | 4.2e-01 |
| 141 | (REACTOME) Intrinsic Pathway of Fibrin Clot Formation | 9.9e-01 | 9.3e-01 | 9.9e-01 | 9.4e-01 | 9.6e-01 | 3.1e-01 |
| 814 | (REACTOME) Hormone ligand-binding receptors | 9.9e-01 | 7.4e-01 | 9.8e-01 | 9.0e-01 | 6.2e-01 | 2.9e-01 |
| 277 | (REACTOME) Synthesis of PIPs at the late endosome membrane | 9.9e-01 | 8.0e-01 | 6.0e-01 | 8.5e-01 | 9.7e-01 | 7.9e-01 |
| 665 | (REACTOME) IRS-related events triggered by IGF1R | 9.9e-01 | 9.1e-01 | 9.5e-01 | 9.9e-01 | 5.7e-01 | 5.6e-01 |
| 1720 | (REACTOME) Nucleotide biosynthesis | 9.9e-01 | 9.4e-01 | 8.3e-01 | 8.5e-01 | 6.4e-01 | 3.3e-01 |
| 1969 | (REACTOME) Sensory processing of sound by outer hair cells of the cochlea | 9.9e-01 | 6.3e-01 | 6.8e-01 | 9.6e-01 | 9.4e-01 | 3.8e-01 |
| 1670 | (REACTOME) GABA synthesis | 9.9e-01 | 8.8e-01 | 9.4e-01 | 8.5e-01 | NA | 7.1e-01 |
| 204 | (REACTOME) Mitochondrial biogenesis | 9.9e-01 | 9.5e-01 | 8.2e-01 | 8.7e-01 | 9.4e-01 | 4.0e-02 |
| 333 | (REACTOME) Viral Messenger RNA Synthesis | 9.9e-01 | 9.0e-01 | 9.2e-01 | 9.9e-01 | 5.5e-01 | 3.0e-02 |
| 1275 | (REACTOME) RHO GTPases Activate Rhotekin and Rhophilins | 9.9e-01 | 6.0e-01 | 8.9e-01 | 9.4e-01 | 5.5e-01 | 2.4e-01 |
| 1757 | (REACTOME) Regulation of cortical dendrite branching | 9.9e-01 | 9.3e-01 | 9.4e-01 | 9.1e-01 | 6.9e-01 | 8.6e-01 |
| 451 | (REACTOME) FGFR1b ligand binding and activation | 9.9e-01 | 8.6e-01 | 8.5e-01 | 8.5e-01 | 7.2e-01 | 7.6e-01 |
| 741 | (REACTOME) HDMs demethylate histones | 9.9e-01 | 1.1e-01 | 9.6e-01 | 9.8e-01 | 9.4e-01 | 5.6e-01 |
| 573 | (REACTOME) MicroRNA (miRNA) biogenesis | 9.9e-01 | 6.2e-01 | 8.5e-01 | 1.0e+00 | 9.2e-01 | 3.1e-01 |
| 1093 | (REACTOME) Miscellaneous transport and binding events | 9.9e-01 | 8.3e-01 | 9.2e-01 | 9.1e-01 | 8.6e-01 | 4.7e-01 |
| 1682 | (REACTOME) RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | 9.9e-01 | 9.1e-01 | 5.6e-01 | 9.1e-01 | 7.2e-01 | 8.6e-01 |
| 159 | (REACTOME) Reproduction | 9.9e-01 | 8.3e-01 | 6.0e-01 | 1.0e+00 | 8.4e-01 | 6.6e-01 |
| 25 | (REACTOME) Release of apoptotic factors from the mitochondria | 9.9e-01 | 8.1e-01 | 9.8e-01 | 1.0e+00 | 8.1e-01 | 9.3e-01 |
| 60 | (REACTOME) Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 9.9e-01 | 8.5e-01 | 9.7e-01 | 9.4e-01 | 8.8e-01 | 9.3e-01 |
| 77 | (REACTOME) Meiotic synapsis | 9.9e-01 | 5.8e-01 | 9.4e-01 | 9.4e-01 | 7.2e-01 | 8.7e-01 |
| 750 | (REACTOME) STAT6-mediated induction of chemokines | 9.9e-01 | 5.1e-01 | 7.5e-01 | 1.0e+00 | 4.2e-01 | 6.6e-01 |
| 1020 | (REACTOME) Interleukin-12 family signaling | 9.9e-01 | 4.7e-01 | 8.6e-01 | 9.1e-01 | 7.4e-01 | 4.3e-01 |
| 1199 | (REACTOME) RHO GTPases activate KTN1 | 9.9e-01 | 9.6e-01 | 9.6e-01 | 9.6e-01 | 6.5e-01 | 7.1e-01 |
| 1549 | (REACTOME) Processing of Capped Intronless Pre-mRNA | 9.9e-01 | 9.8e-01 | 8.5e-01 | 9.4e-01 | 8.6e-01 | 6.9e-01 |
| 1756 | (REACTOME) SLIT2:ROBO1 increases RHOA activity | 9.9e-01 | 5.9e-01 | 9.5e-01 | 9.5e-01 | 8.2e-01 | 5.5e-01 |
| 321 | (REACTOME) Transport of Ribonucleoproteins into the Host Nucleus | 9.9e-01 | 8.0e-01 | 8.8e-01 | 1.0e+00 | 7.6e-01 | 1.5e-01 |
| 194 | (REACTOME) Elastic fibre formation | 9.9e-01 | 4.4e-01 | 7.1e-01 | 9.4e-01 | 6.4e-01 | 5.0e-02 |
| 205 | (REACTOME) Transport of the SLBP independent Mature mRNA | 9.9e-01 | 6.7e-01 | 7.5e-01 | 1.0e+00 | 7.9e-01 | 3.4e-01 |
| 349 | (REACTOME) Regulation of Glucokinase by Glucokinase Regulatory Protein | 9.9e-01 | 7.4e-01 | 9.1e-01 | 9.4e-01 | 8.5e-01 | 1.7e-01 |
| 1181 | (REACTOME) Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | 9.9e-01 | 7.4e-01 | 9.1e-01 | 9.4e-01 | 8.5e-01 | 1.7e-01 |
| 1237 | (REACTOME) FRS-mediated FGFR3 signaling | 9.9e-01 | 7.2e-01 | 9.6e-01 | 9.4e-01 | 3.3e-01 | 4.6e-01 |
| 1540 | (REACTOME) Ketone body metabolism | 9.9e-01 | 5.6e-01 | 8.2e-01 | 8.9e-01 | 4.2e-01 | 7.0e-01 |
| 1919 | (REACTOME) Long-term potentiation | 9.9e-01 | 8.8e-01 | 6.5e-01 | 9.4e-01 | 2.7e-01 | 8.3e-01 |
| 1063 | (REACTOME) Signaling by AXIN mutants | 9.9e-01 | 9.1e-01 | 9.2e-01 | 9.0e-01 | 9.2e-01 | 1.0e+00 |
| 1065 | (REACTOME) Signaling by APC mutants | 9.9e-01 | 9.1e-01 | 9.2e-01 | 9.0e-01 | 9.2e-01 | 1.0e+00 |
| 1066 | (REACTOME) Signaling by AMER1 mutants | 9.9e-01 | 9.1e-01 | 9.2e-01 | 9.0e-01 | 9.2e-01 | 1.0e+00 |
| 1140 | (REACTOME) APC truncation mutants have impaired AXIN binding | 9.9e-01 | 9.1e-01 | 9.2e-01 | 9.0e-01 | 9.2e-01 | 1.0e+00 |
| 1141 | (REACTOME) AXIN missense mutants destabilize the destruction complex | 9.9e-01 | 9.1e-01 | 9.2e-01 | 9.0e-01 | 9.2e-01 | 1.0e+00 |
| 1142 | (REACTOME) Truncations of AMER1 destabilize the destruction complex | 9.9e-01 | 9.1e-01 | 9.2e-01 | 9.0e-01 | 9.2e-01 | 1.0e+00 |
| 170 | (REACTOME) Acyl chain remodelling of PG | 9.9e-01 | 3.7e-01 | 6.0e-01 | 8.5e-01 | 9.2e-01 | 3.1e-01 |
| 1238 | (REACTOME) Downstream signaling of activated FGFR3 | 9.9e-01 | 8.3e-01 | 1.0e+00 | 9.1e-01 | 4.1e-01 | 4.0e-01 |
| 1913 | (REACTOME) Negative regulation of NMDA receptor-mediated neuronal transmission | 9.9e-01 | 9.3e-01 | 9.4e-01 | 9.5e-01 | 4.5e-01 | 6.4e-01 |
| 2159 | (REACTOME) Kinesins | 9.9e-01 | 9.7e-01 | 9.6e-01 | 9.4e-01 | 5.0e-01 | 4.3e-01 |
| 1619 | (REACTOME) MET activates PI3K/AKT signaling | 9.9e-01 | 6.2e-01 | 7.3e-01 | 9.4e-01 | 4.2e-01 | 1.7e-01 |
| 1816 | (REACTOME) Biosynthesis of aspirin-triggered D-series resolvins | 9.9e-01 | 6.8e-01 | 6.0e-01 | 7.9e-01 | 9.6e-01 | 3.8e-01 |
| 913 | (REACTOME) SUMOylation of SUMOylation proteins | 9.9e-01 | 7.4e-01 | 9.1e-01 | 1.0e+00 | 7.7e-01 | 1.1e-01 |
| 208 | (REACTOME) Transport of Mature mRNAs Derived from Intronless Transcripts | 1.0e+00 | 6.8e-01 | 8.3e-01 | 1.0e+00 | 7.5e-01 | 1.6e-01 |
| 739 | (REACTOME) HDACs deacetylate histones | 1.0e+00 | 5.9e-01 | 7.7e-01 | 9.2e-01 | 9.7e-01 | 6.6e-01 |
| 207 | (REACTOME) Transport of Mature mRNA Derived from an Intronless Transcript | 1.0e+00 | 6.7e-01 | 8.0e-01 | 1.0e+00 | 7.1e-01 | 1.6e-01 |
| 1475 | (REACTOME) Urea cycle | 1.0e+00 | 7.8e-01 | 9.7e-01 | 3.0e-01 | 8.3e-01 | 1.3e-01 |
| 664 | (REACTOME) IGF1R signaling cascade | 1.0e+00 | 8.1e-01 | 9.4e-01 | 9.9e-01 | 5.5e-01 | 6.3e-01 |
| 755 | (REACTOME) Nuclear Pore Complex (NPC) Disassembly | 1.0e+00 | 8.0e-01 | 9.3e-01 | 1.0e+00 | 8.9e-01 | 1.3e-01 |
| 778 | (REACTOME) Agmatine biosynthesis | 1.0e+00 | 9.2e-01 | 8.7e-01 | 8.5e-01 | 6.3e-01 | 9.1e-01 |
| 1968 | (REACTOME) Sensory processing of sound by inner hair cells of the cochlea | 1.0e+00 | 7.4e-01 | 8.2e-01 | 9.4e-01 | 7.1e-01 | 5.5e-01 |
| 1999 | (REACTOME) Inhibition of DNA recombination at telomere | 1.0e+00 | 3.3e-01 | 9.0e-01 | 9.8e-01 | 5.1e-01 | 4.7e-01 |
| 999 | (REACTOME) Relaxin receptors | 1.0e+00 | 9.7e-01 | 9.7e-01 | NA | 6.5e-01 | 9.0e-01 |
| 1470 | (REACTOME) Gluconeogenesis | 1.0e+00 | 1.7e-01 | 9.7e-01 | 7.8e-01 | 9.3e-01 | 9.0e-02 |
| 1492 | (REACTOME) U12 Dependent Splicing | 1.0e+00 | 5.1e-01 | 7.9e-01 | 8.9e-01 | 4.5e-01 | 3.0e-01 |
| 1579 | (REACTOME) mitochondrial fatty acid beta-oxidation of saturated fatty acids | 1.0e+00 | 3.8e-01 | 8.3e-01 | 8.8e-01 | 6.1e-01 | 1.0e+00 |
| 1963 | (REACTOME) Signaling by MRAS-complex mutants | 1.0e+00 | 9.2e-01 | 9.0e-01 | 9.1e-01 | 3.4e-01 | 8.0e-01 |
| 2100 | (REACTOME) SHOC2 M1731 mutant abolishes MRAS complex function | 1.0e+00 | 9.2e-01 | 9.0e-01 | 9.1e-01 | 3.4e-01 | 8.0e-01 |
| 2101 | (REACTOME) Gain-of-function MRAS complexes activate RAF signaling | 1.0e+00 | 9.2e-01 | 9.0e-01 | 9.1e-01 | 3.4e-01 | 8.0e-01 |
| 19 | (REACTOME) SLBP independent Processing of Histone Pre-mRNAs | 1.0e+00 | 8.2e-01 | 8.9e-01 | 9.9e-01 | 7.7e-01 | 5.5e-01 |
| 45 | (REACTOME) Electric Transmission Across Gap Junctions | 1.0e+00 | 9.8e-01 | 9.1e-01 | 9.4e-01 | 9.6e-01 | 7.8e-01 |
| 46 | (REACTOME) Transmission across Electrical Synapses | 1.0e+00 | 9.8e-01 | 9.1e-01 | 9.4e-01 | 9.6e-01 | 7.8e-01 |
| 109 | (REACTOME) Mitochondrial protein import | 1.0e+00 | 1.3e-01 | 8.7e-01 | 8.5e-01 | 3.1e-01 | 1.0e-02 |
| 145 | (REACTOME) Amplification of signal from the kinetochores | 1.0e+00 | 9.8e-01 | 8.5e-01 | 1.0e+00 | 9.2e-01 | 1.0e+00 |
| 147 | (REACTOME) Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | 1.0e+00 | 9.8e-01 | 8.5e-01 | 1.0e+00 | 9.2e-01 | 1.0e+00 |
| 178 | (REACTOME) Synthesis of PI | 1.0e+00 | 3.0e-02 | 1.0e+00 | 9.4e-01 | 5.4e-01 | 8.0e-01 |
| 206 | (REACTOME) Transport of the SLBP Dependant Mature mRNA | 1.0e+00 | 6.7e-01 | 7.8e-01 | 1.0e+00 | 8.2e-01 | 3.5e-01 |
| 271 | (REACTOME) Inhibition of TSC complex formation by PKB | 1.0e+00 | 8.1e-01 | 9.7e-01 | 9.4e-01 | 6.9e-01 | 5.6e-01 |
| 352 | (REACTOME) ARMS-mediated activation | 1.0e+00 | 9.8e-01 | 8.5e-01 | 9.9e-01 | 5.5e-01 | 7.9e-01 |
| 381 | (REACTOME) Interactions of Vpr with host cellular proteins | 1.0e+00 | 9.1e-01 | 8.8e-01 | 1.0e+00 | 8.4e-01 | 2.0e-01 |
| 424 | (REACTOME) FGFR2 mutant receptor activation | 1.0e+00 | 5.9e-01 | 9.8e-01 | 9.6e-01 | 7.4e-01 | 5.7e-01 |
| 549 | (REACTOME) Dermatan sulfate biosynthesis | 1.0e+00 | 6.1e-01 | 7.0e-01 | 8.3e-01 | 7.4e-01 | 3.0e-02 |
| 602 | (REACTOME) Gene Silencing by RNA | 1.0e+00 | 9.9e-01 | 9.1e-01 | 9.9e-01 | 8.8e-01 | 1.4e-01 |
| 603 | (REACTOME) AKT-mediated inactivation of FOXO1A | 1.0e+00 | 9.4e-01 | 9.9e-01 | 7.8e-01 | 4.4e-01 | 1.0e-01 |
| 619 | (REACTOME) Molecules associated with elastic fibres | 1.0e+00 | 5.6e-01 | 8.3e-01 | 9.8e-01 | 9.2e-01 | 1.3e-01 |
| 677 | (REACTOME) Resolution of Sister Chromatid Cohesion | 1.0e+00 | 1.0e+00 | 9.1e-01 | 1.0e+00 | 9.1e-01 | 1.0e+00 |
| 746 | (REACTOME) SUMOylation of transcription factors | 1.0e+00 | 7.2e-01 | 9.6e-01 | 9.5e-01 | 3.8e-01 | 8.5e-01 |
| 794 | (REACTOME) Defective CHST6 causes MCDC1 | 1.0e+00 | 6.4e-01 | 8.5e-01 | 9.1e-01 | 4.5e-01 | 1.1e-01 |
| 796 | (REACTOME) Defective ST3GAL3 causes MCT12 and EIEE15 | 1.0e+00 | 8.3e-01 | 8.5e-01 | 8.7e-01 | 7.3e-01 | 1.2e-01 |
| 943 | (REACTOME) Synthesis, secretion, and deacylation of Ghrelin | 1.0e+00 | 7.7e-01 | 6.0e-01 | 9.4e-01 | 6.1e-01 | 9.0e-01 |
| 1064 | (REACTOME) Signaling by CTNNB1 phospho-site mutants | 1.0e+00 | 8.9e-01 | 8.9e-01 | 9.0e-01 | 9.4e-01 | 1.0e+00 |
| 1069 | (REACTOME) Pyrimidine biosynthesis | 1.0e+00 | 9.4e-01 | 9.5e-01 | 9.2e-01 | 9.9e-01 | 4.5e-01 |
| 1076 | (REACTOME) Defective C1GALT1C1 causes TNPS | 1.0e+00 | 8.1e-01 | 6.0e-01 | 9.5e-01 | 9.3e-01 | 6.6e-01 |
| 1079 | (REACTOME) Defective GALNT12 causes CRCS1 | 1.0e+00 | 9.5e-01 | 6.5e-01 | 8.8e-01 | 7.9e-01 | 9.0e-01 |
| 1111 | (REACTOME) Signaling by GSK3beta mutants | 1.0e+00 | 8.9e-01 | 8.9e-01 | 9.0e-01 | 9.4e-01 | 1.0e+00 |
| 1125 | (REACTOME) CTNNB1 S33 mutants aren’t phosphorylated | 1.0e+00 | 8.9e-01 | 8.9e-01 | 9.0e-01 | 9.4e-01 | 1.0e+00 |
| 1126 | (REACTOME) CTNNB1 S37 mutants aren’t phosphorylated | 1.0e+00 | 8.9e-01 | 8.9e-01 | 9.0e-01 | 9.4e-01 | 1.0e+00 |
| 1127 | (REACTOME) CTNNB1 S45 mutants aren’t phosphorylated | 1.0e+00 | 8.9e-01 | 8.9e-01 | 9.0e-01 | 9.4e-01 | 1.0e+00 |
| 1128 | (REACTOME) CTNNB1 T41 mutants aren’t phosphorylated | 1.0e+00 | 8.9e-01 | 8.9e-01 | 9.0e-01 | 9.4e-01 | 1.0e+00 |
| 1133 | (REACTOME) Mitochondrial translation initiation | 1.0e+00 | 1.0e-02 | 6.0e-01 | 8.5e-01 | 2.3e-01 | 0.0e+00 |
| 1134 | (REACTOME) Mitochondrial translation | 1.0e+00 | 0.0e+00 | 6.0e-01 | 8.5e-01 | 1.7e-01 | 0.0e+00 |
| 1137 | (REACTOME) Mitochondrial translation elongation | 1.0e+00 | 1.0e-02 | 6.0e-01 | 8.5e-01 | 2.0e-01 | 0.0e+00 |
| 1152 | (REACTOME) Transcriptional regulation by small RNAs | 1.0e+00 | 9.7e-01 | 9.7e-01 | 1.0e+00 | 6.0e-01 | 4.0e-02 |
| 1158 | (REACTOME) PIWI-interacting RNA (piRNA) biogenesis | 1.0e+00 | 2.9e-01 | 8.3e-01 | 9.2e-01 | 7.6e-01 | 4.4e-01 |
| 1182 | (REACTOME) Defective SLC3A1 causes cystinuria (CSNU) | 1.0e+00 | 5.9e-01 | NA | 9.9e-01 | 6.9e-01 | 9.0e-02 |
| 1228 | (REACTOME) Downstream signaling of activated FGFR1 | 1.0e+00 | 5.1e-01 | 9.0e-01 | 9.4e-01 | 7.1e-01 | 6.6e-01 |
| 1230 | (REACTOME) PI-3K cascade:FGFR1 | 1.0e+00 | 8.1e-01 | 8.5e-01 | 9.4e-01 | 4.3e-01 | 5.0e-01 |
| 1232 | (REACTOME) PI-3K cascade:FGFR2 | 1.0e+00 | 8.1e-01 | 9.6e-01 | 9.4e-01 | 7.4e-01 | 4.9e-01 |
| 1233 | (REACTOME) Downstream signaling of activated FGFR2 | 1.0e+00 | 7.6e-01 | 9.9e-01 | 9.9e-01 | 7.0e-01 | 4.3e-01 |
| 1234 | (REACTOME) SHC-mediated cascade:FGFR2 | 1.0e+00 | 7.5e-01 | 9.4e-01 | 9.4e-01 | 6.0e-01 | 5.4e-01 |
| 1235 | (REACTOME) FRS-mediated FGFR2 signaling | 1.0e+00 | 8.1e-01 | 9.6e-01 | 9.2e-01 | 7.5e-01 | 5.1e-01 |
| 1239 | (REACTOME) PI-3K cascade:FGFR3 | 1.0e+00 | 8.9e-01 | 9.6e-01 | 9.4e-01 | 2.4e-01 | 4.5e-01 |
| 1252 | (REACTOME) Signaling by FGFR2 in disease | 1.0e+00 | 8.1e-01 | 1.0e+00 | 9.5e-01 | 7.9e-01 | 3.6e-01 |
| 1255 | (REACTOME) Signaling by FGFR3 in disease | 1.0e+00 | 8.1e-01 | 9.9e-01 | 9.1e-01 | 6.1e-01 | 3.1e-01 |
| 1267 | (REACTOME) Defective SLC7A9 causes cystinuria (CSNU) | 1.0e+00 | 5.9e-01 | NA | 9.9e-01 | 6.9e-01 | 9.0e-02 |
| 1274 | (REACTOME) RHO GTPases Activate Formins | 1.0e+00 | 9.2e-01 | 7.7e-01 | 1.0e+00 | 9.2e-01 | 9.0e-01 |
| 1338 | (REACTOME) Deposition of new CENPA-containing nucleosomes at the centromere | 1.0e+00 | 7.5e-01 | 9.9e-01 | 9.8e-01 | 6.0e-01 | 1.0e+00 |
| 1416 | (REACTOME) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.0e+00 | 6.2e-01 | 6.1e-01 | 9.5e-01 | 9.8e-01 | 5.7e-01 |
| 1464 | (REACTOME) Mitotic Spindle Checkpoint | 1.0e+00 | 8.2e-01 | 8.5e-01 | 1.0e+00 | 7.6e-01 | 8.3e-01 |
| 1584 | (REACTOME) Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 1.0e+00 | 5.1e-01 | 8.3e-01 | 9.0e-01 | 6.7e-01 | 8.8e-01 |
| 1585 | (REACTOME) Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 1.0e+00 | 4.4e-01 | 8.5e-01 | 9.2e-01 | 7.8e-01 | 9.1e-01 |
| 1589 | (REACTOME) Nucleosome assembly | 1.0e+00 | 7.5e-01 | 9.9e-01 | 9.8e-01 | 6.0e-01 | 1.0e+00 |
| 1590 | (REACTOME) SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 1.0e+00 | 8.3e-01 | 9.2e-01 | 9.8e-01 | 8.2e-01 | 5.8e-01 |
| 1615 | (REACTOME) Synaptic adhesion-like molecules | 1.0e+00 | 9.9e-01 | 8.5e-01 | 9.6e-01 | 5.1e-01 | 7.3e-01 |
| 1617 | (REACTOME) Signaling by FGFR2 IIIa TM | 1.0e+00 | 4.1e-01 | 9.9e-01 | 9.5e-01 | 6.1e-01 | 4.1e-01 |
| 1854 | (REACTOME) Activated NTRK2 signals through CDK5 | 1.0e+00 | 4.0e-01 | 8.3e-01 | 1.0e+00 | 6.7e-01 | 4.8e-01 |
| 1917 | (REACTOME) Activation of AMPK downstream of NMDARs | 1.0e+00 | 9.6e-01 | 8.3e-01 | 9.7e-01 | 4.2e-01 | 3.6e-01 |
| 1950 | (REACTOME) EML4 and NUDC in mitotic spindle formation | 1.0e+00 | 9.9e-01 | 8.7e-01 | 9.8e-01 | 9.2e-01 | 1.0e+00 |
| 1961 | (REACTOME) Sensory processing of sound | 1.0e+00 | 8.1e-01 | 6.7e-01 | 1.0e+00 | 7.2e-01 | 5.0e-01 |
| 78 | (REACTOME) Tolerance of reactive oxygen produced by macrophages | NA | NA | NA | NA | NA | NA |
| 79 | (REACTOME) Mtb iron assimilation by chelation | NA | NA | NA | NA | NA | NA |
| 80 | (REACTOME) Latent infection - Other responses of Mtb to phagocytosis | NA | NA | NA | NA | NA | NA |
| 81 | (REACTOME) Tolerance by Mtb to nitric oxide produced by macrophages | NA | NA | NA | NA | NA | NA |
| 82 | (REACTOME) Cell redox homeostasis | NA | NA | NA | NA | NA | NA |
| 239 | (REACTOME) Formation of ATP by chemiosmotic coupling | NA | NA | NA | NA | NA | NA |
| 320 | (REACTOME) Fusion and Uncoating of the Influenza Virion | NA | NA | NA | NA | NA | NA |
| 327 | (REACTOME) Fusion of the Influenza Virion to the Host Cell Endosome | NA | NA | NA | NA | NA | NA |
| 328 | (REACTOME) Release | NA | NA | NA | NA | NA | NA |
| 329 | (REACTOME) Budding | NA | NA | NA | NA | NA | NA |
| 330 | (REACTOME) Packaging of Eight RNA Segments | NA | NA | NA | NA | NA | NA |
| 336 | (REACTOME) Uncoating of the Influenza Virion | NA | NA | NA | NA | NA | NA |
| 470 | (REACTOME) Digestion of dietary lipid | NA | 6.1e-01 | 9.0e-01 | NA | NA | NA |
| 473 | (REACTOME) cRNA Synthesis | NA | NA | NA | NA | NA | NA |
| 597 | (REACTOME) Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells | NA | 8.8e-01 | NA | NA | NA | NA |
| 1292 | (REACTOME) Defective ABCG8 causes GBD4 and sitosterolemia | NA | 9.0e-01 | NA | 9.4e-01 | NA | NA |
| 1293 | (REACTOME) Defective ABCG5 causes sitosterolemia | NA | 9.0e-01 | NA | 9.4e-01 | NA | NA |
| 1942 | (REACTOME) Antimicrobial action and antimicrobial resistance in Mtb | NA | NA | NA | NA | NA | NA |
| 2025 | (REACTOME) Virion Assembly and Release_1 | NA | NA | NA | NA | NA | NA |
| 2029 | (REACTOME) Transcription of SARS-CoV-1 sgRNAs | NA | NA | NA | NA | NA | NA |
| 2030 | (REACTOME) Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC) | NA | NA | NA | NA | NA | NA |
| 2036 | (REACTOME) Maturation of replicase proteins_1 | NA | NA | NA | NA | NA | NA |
| 2041 | (REACTOME) SARS-CoV-1 targets PDZ proteins in cell-cell junction | NA | NA | NA | NA | NA | NA |
| 2046 | (REACTOME) Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC) | NA | NA | NA | NA | NA | NA |
| 2047 | (REACTOME) Maturation of replicase proteins_2 | NA | NA | NA | NA | NA | NA |
| 2048 | (REACTOME) Virion Assembly and Release_2 | NA | NA | NA | NA | NA | NA |
| 2059 | (REACTOME) Transcription of SARS-CoV-2 sgRNAs | NA | NA | NA | NA | NA | NA |
| 2166 | (REACTOME) ALKBH2 mediated reversal of alkylation damage | NA | NA | NA | NA | NA | NA |
| 2167 | (REACTOME) HCN channels | NA | NA | NA | NA | NA | NA |
| 2168 | (REACTOME) Mitochondrial ABC transporters | NA | NA | NA | NA | NA | NA |
| 2169 | (REACTOME) Amine Oxidase reactions | NA | NA | NA | NA | NA | NA |
| 2170 | (REACTOME) COX reactions | NA | NA | NA | NA | NA | NA |
| 2171 | (REACTOME) Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB | NA | NA | NA | NA | NA | NA |
| 2172 | (REACTOME) PAOs oxidise polyamines to amines | NA | NA | NA | NA | NA | NA |
| 2173 | (REACTOME) Reversible hydration of carbon dioxide | NA | NA | NA | NA | NA | NA |
| 2174 | (REACTOME) Synthesis of CL | NA | NA | NA | NA | NA | NA |
| 2175 | (REACTOME) Synthesis of PS | NA | NA | NA | NA | NA | NA |
| 2176 | (REACTOME) Synthesis of BMP | NA | NA | NA | NA | NA | NA |
| 2177 | (REACTOME) Acetylation | NA | NA | NA | NA | NA | NA |
| 2178 | (REACTOME) Mitochondrial Uncoupling | NA | NA | NA | NA | NA | NA |
| 2179 | (REACTOME) The fatty acid cycling model | NA | NA | NA | NA | NA | NA |
| 2180 | (REACTOME) The proton buffering model | NA | NA | NA | NA | NA | NA |
| 2181 | (REACTOME) Conjugation of phenylacetate with glutamine | NA | NA | NA | NA | NA | NA |
| 2182 | (REACTOME) Signaling by FGFR1 amplification mutants | NA | NA | NA | NA | NA | NA |
| 2183 | (REACTOME) FGFR4 mutant receptor activation | NA | NA | NA | NA | NA | NA |
| 2184 | (REACTOME) Synthesis of IPs in the ER lumen | NA | NA | NA | NA | NA | NA |
| 2185 | (REACTOME) t(4;14) translocations of FGFR3 | NA | NA | NA | NA | NA | NA |
| 2186 | (REACTOME) Vitamins | NA | NA | NA | NA | NA | NA |
| 2187 | (REACTOME) Fatty acids | NA | NA | NA | NA | NA | NA |
| 2188 | (REACTOME) Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 | NA | NA | NA | NA | NA | NA |
| 2189 | (REACTOME) Miscellaneous substrates | NA | NA | NA | NA | NA | NA |
| 2190 | (REACTOME) Eicosanoids | NA | NA | NA | NA | NA | NA |
| 2191 | (REACTOME) Sterols are 12-hydroxylated by CYP8B1 | NA | NA | NA | NA | NA | NA |
| 2192 | (REACTOME) CYP2E1 reactions | NA | NA | NA | NA | NA | NA |
| 2193 | (REACTOME) Synthesis of Hepoxilins (HX) and Trioxilins (TrX) | NA | NA | NA | NA | NA | NA |
| 2194 | (REACTOME) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) | NA | NA | NA | NA | NA | NA |
| 2195 | (REACTOME) Phenylketonuria | NA | NA | NA | NA | NA | NA |
| 2196 | (REACTOME) FMO oxidises nucleophiles | NA | NA | NA | NA | NA | NA |
| 2197 | (REACTOME) Mucopolysaccharidoses | NA | NA | NA | NA | NA | NA |
| 2198 | (REACTOME) MPS VI - Maroteaux-Lamy syndrome | NA | NA | NA | NA | NA | NA |
| 2199 | (REACTOME) MPS II - Hunter syndrome | NA | NA | NA | NA | NA | NA |
| 2200 | (REACTOME) Phosphate bond hydrolysis by NUDT proteins | NA | NA | NA | NA | NA | NA |
| 2201 | (REACTOME) Electron transport from NADPH to Ferredoxin | NA | NA | NA | NA | NA | NA |
| 2202 | (REACTOME) Formation of selenosugars for excretion | NA | NA | NA | NA | NA | NA |
| 2203 | (REACTOME) Methylation of MeSeH for excretion | NA | NA | NA | NA | NA | NA |
| 2204 | (REACTOME) Biosynthesis of A2E, implicated in retinal degradation | NA | NA | NA | NA | NA | NA |
| 2205 | (REACTOME) Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate | NA | NA | NA | NA | NA | NA |
| 2206 | (REACTOME) Regulation by TREX1 | NA | NA | NA | NA | NA | NA |
| 2207 | (REACTOME) Regulation of thyroid hormone activity | NA | NA | NA | NA | NA | NA |
| 2208 | (REACTOME) Metabolism of serotonin | NA | NA | NA | NA | NA | NA |
| 2209 | (REACTOME) NADPH regeneration | NA | NA | NA | NA | NA | NA |
| 2210 | (REACTOME) Lysosphingolipid and LPA receptors | NA | NA | NA | NA | NA | NA |
| 2211 | (REACTOME) Multifunctional anion exchangers | NA | NA | NA | NA | NA | NA |
| 2212 | (REACTOME) Proton/oligopeptide cotransporters | NA | NA | NA | NA | NA | NA |
| 2213 | (REACTOME) Passive transport by Aquaporins | NA | NA | NA | NA | NA | NA |
| 2214 | (REACTOME) Synthesis of dolichyl-phosphate-glucose | NA | NA | NA | NA | NA | NA |
| 2215 | (REACTOME) Oxidative demethylation of DNA | NA | NA | NA | NA | NA | NA |
| 2216 | (REACTOME) Metabolism of ingested MeSeO2H into MeSeH | NA | NA | NA | NA | NA | NA |
| 2217 | (REACTOME) Defective AHCY causes HMAHCHD | NA | NA | NA | NA | NA | NA |
| 2218 | (REACTOME) Defective GSS causes GSS deficiency | NA | NA | NA | NA | NA | NA |
| 2219 | (REACTOME) Defective ACY1 causes encephalopathy | NA | NA | NA | NA | NA | NA |
| 2220 | (REACTOME) Defective MAOA causes BRUNS | NA | NA | NA | NA | NA | NA |
| 2221 | (REACTOME) Defective FMO3 causes TMAU | NA | NA | NA | NA | NA | NA |
| 2222 | (REACTOME) Defective MAT1A causes MATD | NA | NA | NA | NA | NA | NA |
| 2223 | (REACTOME) Defective PGM1 causes CDG1t | NA | NA | NA | NA | NA | NA |
| 2224 | (REACTOME) Defective GALE causes EDG | NA | NA | NA | NA | NA | NA |
| 2225 | (REACTOME) Metallothioneins bind metals | NA | NA | NA | NA | NA | NA |
| 2226 | (REACTOME) Metabolism of vitamin K | NA | NA | NA | NA | NA | NA |
| 2227 | (REACTOME) Pyrophosphate hydrolysis | NA | NA | NA | NA | NA | NA |
| 2228 | (REACTOME) Transport of nucleotide sugars | NA | NA | NA | NA | NA | NA |
| 2229 | (REACTOME) PRPP biosynthesis | NA | NA | NA | NA | NA | NA |
| 2230 | (REACTOME) mRNA Editing: A to I Conversion | NA | NA | NA | NA | NA | NA |
| 2231 | (REACTOME) C6 deamination of adenosine | NA | NA | NA | NA | NA | NA |
| 2232 | (REACTOME) Phosphate bond hydrolysis by NTPDase proteins | NA | NA | NA | NA | NA | NA |
| 2233 | (REACTOME) Signaling by FGFR2 fusions | NA | NA | NA | NA | NA | NA |
| 2234 | (REACTOME) Signaling by FGFR3 fusions in cancer | NA | NA | NA | NA | NA | NA |
| 2235 | (REACTOME) Signaling by plasma membrane FGFR1 fusions | NA | NA | NA | NA | NA | NA |
| 2236 | (REACTOME) Reuptake of GABA | NA | NA | NA | NA | NA | NA |
| 2237 | (REACTOME) Events associated with phagocytolytic activity of PMN cells | NA | NA | NA | NA | NA | NA |
| 2238 | (REACTOME) Intestinal lipid absorption | NA | NA | NA | NA | NA | NA |
| 2239 | (REACTOME) Alanine metabolism | NA | NA | NA | NA | NA | NA |
| 2240 | (REACTOME) Intracellular oxygen transport | NA | NA | NA | NA | NA | NA |
| 2241 | (REACTOME) Biosynthesis of maresins | NA | NA | NA | NA | NA | NA |
| 2242 | (REACTOME) Biosynthesis of DPAn-6 SPMs | NA | NA | NA | NA | NA | NA |
| 2243 | (REACTOME) Biosynthesis of DHA-derived sulfido conjugates | NA | NA | NA | NA | NA | NA |
| 2244 | (REACTOME) Biosynthesis of DPAn-3-derived 13-series resolvins | NA | NA | NA | NA | NA | NA |
| 2245 | (REACTOME) Biosynthesis of maresin conjugates in tissue regeneration (MCTR) | NA | NA | NA | NA | NA | NA |
| 2246 | (REACTOME) Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) | NA | NA | NA | NA | NA | NA |
| 2247 | (REACTOME) Biosynthesis of maresin-like SPMs | NA | NA | NA | NA | NA | NA |
| 2248 | (REACTOME) Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives | NA | NA | NA | NA | NA | NA |
| 2249 | (REACTOME) Escape of Mtb from the phagocyte | NA | NA | NA | NA | NA | NA |
| 2250 | (REACTOME) Phagocyte cell death caused by cytosolic Mtb | NA | NA | NA | NA | NA | NA |
| 2251 | (REACTOME) Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 | NA | NA | NA | NA | NA | NA |
| 2252 | (REACTOME) Signaling by kinase domain mutants of KIT | NA | NA | NA | NA | NA | NA |
| 2253 | (REACTOME) Signaling by juxtamembrane domain KIT mutants | NA | NA | NA | NA | NA | NA |
| 2254 | (REACTOME) Oleoyl-phe metabolism | NA | NA | NA | NA | NA | NA |
| 2255 | (REACTOME) Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | NA | NA | NA | NA | NA | NA |
| 2256 | (REACTOME) Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | NA | NA | NA | NA | NA | NA |
| 2257 | (REACTOME) Signaling by extracellular domain mutants of KIT | NA | NA | NA | NA | NA | NA |
| 2258 | (REACTOME) Translation of Accessory Proteins | NA | NA | NA | NA | NA | NA |
| 2259 | (REACTOME) Sensory perception of sour taste | NA | NA | NA | NA | NA | NA |
| 2260 | (REACTOME) Nucleotide salvage defects | NA | NA | NA | NA | NA | NA |
| 2261 | (REACTOME) Defective HPRT1 disrupts guanine and hypoxanthine salvage | NA | NA | NA | NA | NA | NA |
| 2262 | (REACTOME) Diseases of nucleotide metabolism | NA | NA | NA | NA | NA | NA |
| 2263 | (REACTOME) Regulation of NPAS4 gene transcription | NA | NA | NA | NA | NA | NA |
| 2264 | (REACTOME) Classical Kir channels | NA | NA | NA | NA | NA | NA |
| 2265 | (REACTOME) Tandem pore domain halothane-inhibited K+ channel (THIK) | NA | NA | NA | NA | NA | NA |
| 2266 | (REACTOME) Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) | NA | NA | NA | NA | NA | NA |
| 2267 | (REACTOME) TWIK-related spinal cord K+ channel (TRESK) | NA | NA | NA | NA | NA | NA |
| 2268 | (REACTOME) TWIK-related alkaline pH activated K+ channel (TALK) | NA | NA | NA | NA | NA | NA |
| 2269 | (REACTOME) TWIK related potassium channel (TREK) | NA | NA | NA | NA | NA | NA |
| 2270 | (REACTOME) PI and PC transport between ER and Golgi membranes | NA | NA | NA | NA | NA | NA |
| 2271 | (REACTOME) Transfer of LPS from LBP carrier to CD14 | NA | NA | NA | NA | NA | NA |
| 2272 | (REACTOME) Hyaluronan biosynthesis and export | NA | NA | NA | NA | NA | NA |
| 2273 | (REACTOME) MPS IX - Natowicz syndrome | NA | NA | NA | NA | NA | NA |
| 2274 | (REACTOME) MPS IIIB - Sanfilippo syndrome B | NA | NA | NA | NA | NA | NA |
| 2275 | (REACTOME) MPS IV - Morquio syndrome A | NA | NA | NA | NA | NA | NA |
| 2276 | (REACTOME) MPS IIIC - Sanfilippo syndrome C | NA | NA | NA | NA | NA | NA |
| 2277 | (REACTOME) MPS VII - Sly syndrome | NA | NA | NA | NA | NA | NA |
| 2278 | (REACTOME) MPS I - Hurler syndrome | NA | NA | NA | NA | NA | NA |
| 2279 | (REACTOME) MPS IIID - Sanfilippo syndrome D | NA | NA | NA | NA | NA | NA |
| 2280 | (REACTOME) MPS IIIA - Sanfilippo syndrome A | NA | NA | NA | NA | NA | NA |
| 2281 | (REACTOME) MPS IV - Morquio syndrome B | NA | NA | NA | NA | NA | NA |
| 2282 | (REACTOME) GSD Ib | NA | NA | NA | NA | NA | NA |
| 2283 | (REACTOME) GSD Ia | NA | NA | NA | NA | NA | NA |
| 2284 | (REACTOME) SCN4 | NA | NA | NA | NA | NA | NA |
| 2285 | (REACTOME) TRP channels | NA | NA | NA | NA | NA | NA |
| 2286 | (REACTOME) Hydroxycarboxylic acid-binding receptors | NA | NA | NA | NA | NA | NA |
| 2287 | (REACTOME) Defective MMAB causes MMA, cblB type | NA | NA | NA | NA | NA | NA |
| 2288 | (REACTOME) Defective MMADHC causes MMAHCD | NA | NA | NA | NA | NA | NA |
| 2289 | (REACTOME) Defective CD320 causes MMATC | NA | NA | NA | NA | NA | NA |
| 2290 | (REACTOME) Defective BTD causes biotidinase deficiency | NA | NA | NA | NA | NA | NA |
| 2291 | (REACTOME) Defective SLC26A2 causes chondrodysplasias | NA | NA | NA | NA | NA | NA |
| 2292 | (REACTOME) Defective PAPSS2 causes SEMD-PA | NA | NA | NA | NA | NA | NA |
| 2293 | (REACTOME) Defective HEXA causes GM2G1 | NA | NA | NA | NA | NA | NA |
| 2294 | (REACTOME) Defective HEXB causes GM2G2 | NA | NA | NA | NA | NA | NA |
| 2295 | (REACTOME) Muscarinic acetylcholine receptors | NA | NA | NA | NA | NA | NA |
| 2296 | (REACTOME) Histamine receptors | NA | NA | NA | NA | NA | NA |
| 2297 | (REACTOME) Dopamine receptors | NA | NA | NA | NA | NA | NA |
| 2298 | (REACTOME) Serotonin receptors | NA | NA | NA | NA | NA | NA |
| 2299 | (REACTOME) Eicosanoid ligand-binding receptors | NA | NA | NA | NA | NA | NA |
| 2300 | (REACTOME) Leukotriene receptors | NA | NA | NA | NA | NA | NA |
| 2301 | (REACTOME) Prostanoid ligand receptors | NA | NA | NA | NA | NA | NA |
| 2302 | (REACTOME) Adrenaline signalling through Alpha-2 adrenergic receptor | NA | NA | NA | NA | NA | NA |
| 2303 | (REACTOME) Defective PMM2 causes CDG-1a | NA | NA | NA | NA | NA | NA |
| 2304 | (REACTOME) Defective MPI causes CDG-1b | NA | NA | NA | NA | NA | NA |
| 2305 | (REACTOME) Defective GNE causes sialuria, NK and IBM2 | NA | NA | NA | NA | NA | NA |
| 2306 | (REACTOME) Defective GFPT1 causes CMSTA1 | NA | NA | NA | NA | NA | NA |
| 2307 | (REACTOME) P2Y receptors | NA | NA | NA | NA | NA | NA |
| 2308 | (REACTOME) Adenosine P1 receptors | NA | NA | NA | NA | NA | NA |
| 2309 | (REACTOME) Nucleotide-like (purinergic) receptors | NA | NA | NA | NA | NA | NA |
| 2310 | (REACTOME) Reduction of cytosolic Ca++ levels | NA | NA | NA | NA | NA | NA |
| 2311 | (REACTOME) Opsins | NA | NA | NA | NA | NA | NA |
| 2312 | (REACTOME) Type II Na+/Pi cotransporters | NA | NA | NA | NA | NA | NA |
| 2313 | (REACTOME) Sodium-coupled phosphate cotransporters | NA | NA | NA | NA | NA | NA |
| 2314 | (REACTOME) Proton-coupled neutral amino acid transporters | NA | NA | NA | NA | NA | NA |
| 2315 | (REACTOME) Inositol transporters | NA | NA | NA | NA | NA | NA |
| 2316 | (REACTOME) Sodium-coupled sulphate, di- and tri-carboxylate transporters | NA | NA | NA | NA | NA | NA |
| 2317 | (REACTOME) Zinc efflux and compartmentalization by the SLC30 family | NA | NA | NA | NA | NA | NA |
| 2318 | (REACTOME) Zinc influx into cells by the SLC39 gene family | NA | NA | NA | NA | NA | NA |
| 2319 | (REACTOME) Free fatty acid receptors | NA | NA | NA | NA | NA | NA |
| 2320 | (REACTOME) Defective ALG2 causes CDG-1i | NA | NA | NA | NA | NA | NA |
| 2321 | (REACTOME) Defective DPAGT1 causes CDG-1j, CMSTA2 | NA | NA | NA | NA | NA | NA |
| 2322 | (REACTOME) Defective ALG1 causes CDG-1k | NA | NA | NA | NA | NA | NA |
| 2323 | (REACTOME) Defective ALG11 causes CDG-1p | NA | NA | NA | NA | NA | NA |
| 2324 | (REACTOME) Defective RFT1 causes CDG-1n | NA | NA | NA | NA | NA | NA |
| 2325 | (REACTOME) Defective MPDU1 causes CDG-1f | NA | NA | NA | NA | NA | NA |
| 2326 | (REACTOME) Defective ALG9 causes CDG-1l | NA | NA | NA | NA | NA | NA |
| 2327 | (REACTOME) Defective ALG3 causes CDG-1d | NA | NA | NA | NA | NA | NA |
| 2328 | (REACTOME) Defective ALG12 causes CDG-1g | NA | NA | NA | NA | NA | NA |
| 2329 | (REACTOME) Defective ALG6 causes CDG-1c | NA | NA | NA | NA | NA | NA |
| 2330 | (REACTOME) Defective ALG8 causes CDG-1h | NA | NA | NA | NA | NA | NA |
| 2331 | (REACTOME) Defective SRD5A3 causes CDG-1q and KHRZ | NA | NA | NA | NA | NA | NA |
| 2332 | (REACTOME) Defective DOLK causes CDG-1m | NA | NA | NA | NA | NA | NA |
| 2333 | (REACTOME) Defective MAN1B1 causes MRT15 | NA | NA | NA | NA | NA | NA |
| 2334 | (REACTOME) Defective MGAT2 causes CDG-2a | NA | NA | NA | NA | NA | NA |
| 2335 | (REACTOME) Defective B4GALT1 causes CDG-2d | NA | NA | NA | NA | NA | NA |
| 2336 | (REACTOME) Defective MOGS causes CDG-2b | NA | NA | NA | NA | NA | NA |
| 2337 | (REACTOME) XAV939 stabilizes AXIN | NA | NA | NA | NA | NA | NA |
| 2338 | (REACTOME) Defective TPMT causes TPMT deficiency | NA | NA | NA | NA | NA | NA |
| 2339 | (REACTOME) Defective CYP27A1 causes CTX | NA | NA | NA | NA | NA | NA |
| 2340 | (REACTOME) Defective OPLAH causes OPLAHD | NA | NA | NA | NA | NA | NA |
| 2341 | (REACTOME) Defective CYP1B1 causes Glaucoma | NA | NA | NA | NA | NA | NA |
| 2342 | (REACTOME) Defective UGT1A1 causes hyperbilirubinemia | NA | NA | NA | NA | NA | NA |
| 2343 | (REACTOME) Defective CYP26C1 causes FFDD4 | NA | NA | NA | NA | NA | NA |
| 2344 | (REACTOME) Defective CYP4F22 causes ARCI5 | NA | NA | NA | NA | NA | NA |
| 2345 | (REACTOME) Defective CYP11B2 causes CMO-1 deficiency | NA | NA | NA | NA | NA | NA |
| 2346 | (REACTOME) Defective CYP24A1 causes HCAI | NA | NA | NA | NA | NA | NA |
| 2347 | (REACTOME) Defective CYP2U1 causes SPG56 | NA | NA | NA | NA | NA | NA |
| 2348 | (REACTOME) Defective CYP7B1 causes SPG5A and CBAS3 | NA | NA | NA | NA | NA | NA |
| 2349 | (REACTOME) Defective CYP27B1 causes VDDR1A | NA | NA | NA | NA | NA | NA |
| 2350 | (REACTOME) Defective CYP26B1 causes RHFCA | NA | NA | NA | NA | NA | NA |
| 2351 | (REACTOME) Defective UGT1A4 causes hyperbilirubinemia | NA | NA | NA | NA | NA | NA |
| 2352 | (REACTOME) Defective CYP11B1 causes AH4 | NA | NA | NA | NA | NA | NA |
| 2353 | (REACTOME) Defective SLC35D1 causes SCHBCKD | NA | NA | NA | NA | NA | NA |
| 2354 | (REACTOME) Defective CYP21A2 causes AH3 | NA | NA | NA | NA | NA | NA |
| 2355 | (REACTOME) Defective GGT1 causes GLUTH | NA | NA | NA | NA | NA | NA |
| 2356 | (REACTOME) Defective CYP27B1 causes VDDR1B | NA | NA | NA | NA | NA | NA |
| 2357 | (REACTOME) Defective CYP17A1 causes AH5 | NA | NA | NA | NA | NA | NA |
| 2358 | (REACTOME) Defective CYP19A1 causes AEXS | NA | NA | NA | NA | NA | NA |
| 2359 | (REACTOME) Defective TBXAS1 causes GHDD | NA | NA | NA | NA | NA | NA |
| 2360 | (REACTOME) Defective GALK1 causes GALCT2 | NA | NA | NA | NA | NA | NA |
| 2361 | (REACTOME) Defective GALT can cause GALCT | NA | NA | NA | NA | NA | NA |
| 2362 | (REACTOME) Organic anion transport | NA | NA | NA | NA | NA | NA |
| 2363 | (REACTOME) Defective SLC17A5 causes Salla disease (SD) and ISSD | NA | NA | NA | NA | NA | NA |
| 2364 | (REACTOME) Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) | NA | NA | NA | NA | NA | NA |
| 2365 | (REACTOME) Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)_1 | NA | NA | NA | NA | NA | NA |
| 2366 | (REACTOME) Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) | NA | NA | NA | NA | NA | NA |
| 2367 | (REACTOME) Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) | NA | NA | NA | NA | NA | NA |
| 2368 | (REACTOME) Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) | NA | NA | NA | NA | NA | NA |
| 2369 | (REACTOME) Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) | NA | NA | NA | NA | NA | NA |
| 2370 | (REACTOME) Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) | NA | NA | NA | NA | NA | NA |
| 2371 | (REACTOME) Defective SLC6A19 causes Hartnup disorder (HND)_1 | NA | NA | NA | NA | NA | NA |
| 2372 | (REACTOME) Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) | NA | NA | NA | NA | NA | NA |
| 2373 | (REACTOME) Defective SLC26A4 causes Pendred syndrome (PDS) | NA | NA | NA | NA | NA | NA |
| 2374 | (REACTOME) Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) | NA | NA | NA | NA | NA | NA |
| 2375 | (REACTOME) Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) | NA | NA | NA | NA | NA | NA |
| 2376 | (REACTOME) Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) | NA | NA | NA | NA | NA | NA |
| 2377 | (REACTOME) Defective SLC9A9 causes autism 16 (AUTS16) | NA | NA | NA | NA | NA | NA |
| 2378 | (REACTOME) Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) | NA | NA | NA | NA | NA | NA |
| 2379 | (REACTOME) Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) | NA | NA | NA | NA | NA | NA |
| 2380 | (REACTOME) Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) | NA | NA | NA | NA | NA | NA |
| 2381 | (REACTOME) Defective HK1 causes hexokinase deficiency (HK deficiency) | NA | NA | NA | NA | NA | NA |
| 2382 | (REACTOME) Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) | NA | NA | NA | NA | NA | NA |
| 2383 | (REACTOME) Defective SLC33A1 causes spastic paraplegia 42 (SPG42) | NA | NA | NA | NA | NA | NA |
| 2384 | (REACTOME) Defective SLC1A3 causes episodic ataxia 6 (EA6) | NA | NA | NA | NA | NA | NA |
| 2385 | (REACTOME) Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) | NA | NA | NA | NA | NA | NA |
| 2386 | (REACTOME) Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) | NA | NA | NA | NA | NA | NA |
| 2387 | (REACTOME) Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) | NA | NA | NA | NA | NA | NA |
| 2388 | (REACTOME) Defective SLC2A10 causes arterial tortuosity syndrome (ATS) | NA | NA | NA | NA | NA | NA |
| 2389 | (REACTOME) Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) | NA | NA | NA | NA | NA | NA |
| 2390 | (REACTOME) Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) | NA | NA | NA | NA | NA | NA |
| 2391 | (REACTOME) Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) | NA | NA | NA | NA | NA | NA |
| 2392 | (REACTOME) Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) | NA | NA | NA | NA | NA | NA |
| 2393 | (REACTOME) Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) | NA | NA | NA | NA | NA | NA |
| 2394 | (REACTOME) Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) | NA | NA | NA | NA | NA | NA |
| 2395 | (REACTOME) Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria_1 | NA | NA | NA | NA | NA | NA |
| 2396 | (REACTOME) Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)_1 | NA | NA | NA | NA | NA | NA |
| 2397 | (REACTOME) Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) | NA | NA | NA | NA | NA | NA |
| 2398 | (REACTOME) Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) | NA | NA | NA | NA | NA | NA |
| 2399 | (REACTOME) Defective SLC12A3 causes Gitelman syndrome (GS) | NA | NA | NA | NA | NA | NA |
| 2400 | (REACTOME) Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) | NA | NA | NA | NA | NA | NA |
| 2401 | (REACTOME) Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | NA | NA | NA | NA | NA | NA |
| 2402 | (REACTOME) Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) | NA | NA | NA | NA | NA | NA |
| 2403 | (REACTOME) Variant SLC6A14 may confer susceptibility towards obesity | NA | NA | NA | NA | NA | NA |
| 2404 | (REACTOME) Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) | NA | NA | NA | NA | NA | NA |
| 2405 | (REACTOME) Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) | NA | NA | NA | NA | NA | NA |
| 2406 | (REACTOME) Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) | NA | NA | NA | NA | NA | NA |
| 2407 | (REACTOME) Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) | NA | NA | NA | NA | NA | NA |
| 2408 | (REACTOME) Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)_1 | NA | NA | NA | NA | NA | NA |
| 2409 | (REACTOME) Defective SLC12A1 causes Bartter syndrome 1 (BS1) | NA | NA | NA | NA | NA | NA |
| 2410 | (REACTOME) Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) | NA | NA | NA | NA | NA | NA |
| 2411 | (REACTOME) Defective SLC6A2 causes orthostatic intolerance (OI) | NA | NA | NA | NA | NA | NA |
| 2412 | (REACTOME) Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) | NA | NA | NA | NA | NA | NA |
| 2413 | (REACTOME) Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | NA | NA | NA | NA | NA | NA |
| 2414 | (REACTOME) Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)_1 | NA | NA | NA | NA | NA | NA |
| 2415 | (REACTOME) Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM) | NA | NA | NA | NA | NA | NA |
| 2416 | (REACTOME) Hereditary fructose intolerance | NA | NA | NA | NA | NA | NA |
| 2417 | (REACTOME) Essential fructosuria | NA | NA | NA | NA | NA | NA |
| 2418 | (REACTOME) MGMT-mediated DNA damage reversal | NA | NA | NA | NA | NA | NA |
| 2419 | (REACTOME) Defective SLC5A2 causes renal glucosuria (GLYS1) | NA | NA | NA | NA | NA | NA |
| 2420 | (REACTOME) Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)_2 | NA | NA | NA | NA | NA | NA |
| 2421 | (REACTOME) Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria_2 | NA | NA | NA | NA | NA | NA |
| 2422 | (REACTOME) Defective SLC6A19 causes Hartnup disorder (HND)_2 | NA | NA | NA | NA | NA | NA |
| 2423 | (REACTOME) Intestinal saccharidase deficiencies | NA | NA | NA | NA | NA | NA |
| 2424 | (REACTOME) RPIA deficiency: failed conversion of R5P to RU5P | NA | NA | NA | NA | NA | NA |
| 2425 | (REACTOME) Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)_2 | NA | NA | NA | NA | NA | NA |
| 2426 | (REACTOME) Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)_2 | NA | NA | NA | NA | NA | NA |
| 2427 | (REACTOME) Essential pentosuria | NA | NA | NA | NA | NA | NA |
| 2428 | (REACTOME) Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)_2 | NA | NA | NA | NA | NA | NA |
| 2429 | (REACTOME) PTEN Loss of Function in Cancer | NA | NA | NA | NA | NA | NA |
| 2430 | (REACTOME) Defective ABCB11 causes PFIC2 and BRIC2 | NA | NA | NA | NA | NA | NA |
| 2431 | (REACTOME) Defective ABCB4 causes PFIC3, ICP3 and GBD1 | NA | NA | NA | NA | NA | NA |
| 2432 | (REACTOME) Defective ABCC2 causes DJS | NA | NA | NA | NA | NA | NA |
| 2433 | (REACTOME) Defective ABCA12 causes ARCI4B | NA | NA | NA | NA | NA | NA |
| 2434 | (REACTOME) Defective ABCB6 causes MCOPCB7 | NA | NA | NA | NA | NA | NA |
| 2435 | (REACTOME) Defective ABCA3 causes SMDP3_1 | NA | NA | NA | NA | NA | NA |
| 2436 | (REACTOME) Defective ABCD1 causes ALD | NA | NA | NA | NA | NA | NA |
| 2437 | (REACTOME) Defective SLC34A2 causes PALM | NA | NA | NA | NA | NA | NA |
| 2438 | (REACTOME) Defective ABCA3 causes SMDP3_2 | NA | NA | NA | NA | NA | NA |
| 2439 | (REACTOME) Defective ABCC6 causes PXE | NA | NA | NA | NA | NA | NA |
| 2440 | (REACTOME) TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P | NA | NA | NA | NA | NA | NA |
| 2441 | (REACTOME) RPIA deficiency: failed conversion of RU5P to R5P | NA | NA | NA | NA | NA | NA |
| 2442 | (REACTOME) TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P | NA | NA | NA | NA | NA | NA |
| 2443 | (REACTOME) Pentose phosphate pathway disease | NA | NA | NA | NA | NA | NA |
| 2444 | (REACTOME) Transport of fatty acids | NA | NA | NA | NA | NA | NA |
| 2445 | (REACTOME) Vitamin E | NA | NA | NA | NA | NA | NA |
| 2446 | (REACTOME) Defective GGT1 in aflatoxin detoxification causes GLUTH | NA | NA | NA | NA | NA | NA |
| 2447 | (REACTOME) Diseases of Base Excision Repair | NA | NA | NA | NA | NA | NA |
| 2448 | (REACTOME) RAS GTPase cycle mutants | NA | NA | NA | NA | NA | NA |
| 2449 | (REACTOME) Defective Base Excision Repair Associated with OGG1 | NA | NA | NA | NA | NA | NA |
| 2450 | (REACTOME) Defective OGG1 Substrate Processing | NA | NA | NA | NA | NA | NA |
| 2451 | (REACTOME) Maturation of protein M_1 | NA | NA | NA | NA | NA | NA |
| 2452 | (REACTOME) Maturation of protein M_2 | NA | NA | NA | NA | NA | NA |
| 2453 | (REACTOME) Defective APRT disrupts adenine salvage | NA | NA | NA | NA | NA | NA |
| 2454 | (REACTOME) Defective ADA disrupts (deoxy)adenosine deamination | NA | NA | NA | NA | NA | NA |
| 2455 | (REACTOME) Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine | NA | NA | NA | NA | NA | NA |
| 2456 | (REACTOME) Nucleotide catabolism defects | NA | NA | NA | NA | NA | NA |
| 2457 | (REACTOME) Signaling by RAS GAP mutants | NA | NA | NA | NA | NA | NA |
| 2458 | (REACTOME) Signaling by RAS GTPase mutants | NA | NA | NA | NA | NA | NA |
| 2459 | (REACTOME) Reactions specific to the hybrid N-glycan synthesis pathway | NA | NA | NA | NA | NA | NA |
| 2460 | (REACTOME) N-Glycan antennae elongation | NA | NA | NA | NA | NA | NA |
Reactome %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table 7. Integrated transcriptomic and metabolomic Reactome pathway analysis - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))rm(list = setdiff(ls(), lsf.str()))
read_excel("../input_files/Upstream/Lung_upstream analysis.xls") %>% row_to_names(row_number=1) -> Lung## New names:
## • `` -> `...2`
## • `` -> `...3`
## • `` -> `...4`
## • `` -> `...5`
## • `` -> `...6`
## • `` -> `...7`
## • `` -> `...8`as.numeric(Lung$`Activation z-score`) -> Lung$`Activation z-score`
Lung <- Lung[order(-Lung$`Activation z-score`),]
as.numeric(Lung$`Expr Log Ratio`) -> Lung$`Expr Log Ratio`
as.numeric(Lung$`p-value of overlap`) -> Lung$`p-value of overlap`
Lung %>%
mutate(
`Expr Log Ratio`=format(round(`Expr Log Ratio`,2),nsmall=2,scientific=TRUE),
`Activation z-score`=format(round(`Activation z-score`,2),nsmall=2,scientific=TRUE),
`p-value of overlap`=format(round(`p-value of overlap`,2),nsmall=2,scientific=TRUE)) %>%
kable(caption = "Supplementary Table S8. Ingenuity upstream regulators predicted to have similar activatory or inhibitory effect to ozone in lung", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(1:8,bold=ifelse(is.na(Lung$`Predicted Activation State`),F,T),color= ifelse(is.na(Lung$`Predicted Activation State`),"gray",ifelse(Lung$`Predicted Activation State` == "Inhibited","#40004B","#00441B"))) %>%
scroll_box(width = "1200px", height = "500px")| Upstream Regulator | Expr Log Ratio | Molecule Type | Predicted Activation State | Activation z-score | p-value of overlap | Target Molecules in Dataset | Mechanistic Network |
|---|---|---|---|---|---|---|---|
| methylprednisolone | NA | chemical drug | Activated | 5.74e+00 | 0.0e+00 | ABCC2,ADGRL2,ANXA3,ARL4A,ASPA,ATP1A1,ATP1B1,BAIAP2,C9,CAMK1D,CBLB,Ccl2,CCL4,CD180,CD19,CD22,CD79B,CDKN1A,CIDEA,CR2,CREM,CTSH,CTSV,CXCL3,Cyp3a25 (includes others),DAB2IP,DDIT4,DIO1,DUSP1,DYNLL1,ECE1,F3,FOS,G0S2,GADD45A,GBP2,GCLC,GNAI2,HMOX1,HSD17B2,HYAL2,IL1A,IL6R,ITGA7,KLF15,LOX,LRP3,LYVE1,MAOB,MAP1LC3B,MGP,MMP9,Mt1,Mx2,MYC,NFKBIA,NR0B2,ODC1,PCTP,PEX11A,PKIA,PKP1,PLA1A,PLAT,PLAUR,POR,PPL,PSAT1,PTPRC,RAMP3,RAPGEF4,RGCC,RGN,RND3,SDC4,SERPINB1,SERPINE1,SLC10A1,SLC13A3,SLC22A7,SLC25A10,SLC26A1,SLC6A13,SMPD3,SNAP23,SOSTDC1,STAT1,THRB,TIMP3,TINAGL1,TLR10,TLR5,Tsc22d3,UBE2G2,ZFP36,ZNF519 | 446 (16) |
| PDGF BB | NA | complex | Activated | 4.45e+00 | 0.0e+00 | ADRA1D,ARG2,ATF3,BHLHE40,BMP3,BMP6,CCL2,Ccl2,CCNO,CDKN1A,CDO1,CEBPD,CREB1,CXCL2,DBNDD1,DUSP1,EDN1,EGR3,EREG,F3,FASN,FOS,FOSL1,GADD45A,GBP2,GEM,GFPT2,GLUL,Gsta1,HMOX1,IER3,INHBA,JUNB,LGALS3,LIF,MMP9,Mt1,MYC,NEXN,NFIL3,NPR3,ODC1,PLAT,PRSS35,PTGS2,RND3,SAT1,SERPINE1,SLC6A6,SLC7A1,SLC7A7,SNURF,SOCS3,SPHK1,THBS1,TIMP1,TNFRSF12A,TRIB1,XDH,ZFP36 | 538 (19) |
| HMG20A | -1.00e-02 | transcription regulator | Activated | 4.38e+00 | 0.0e+00 | ATF3,CXCL10,EDN1,EREG,ERRFI1,F3,FASN,GADD45A,INHBA,LIF,MGP,MYC,OSMR,PLAUR,RGS16,SDC4,SERPINE1,SLC7A1,SPHK1,TIMP1,TIMP3,TNFRSF12A,Tnfsf9 | 338 (13) |
| GNAQ | -1.50e-01 | enzyme | Activated | 4.19e+00 | 0.0e+00 | ABCB1,ADAMTS1,ANKRD1,ANXA3,ATF3,BMP2,BTG2,Ccl2,Clec2d (includes others),CREM,CTSV,CXCL3,EDN1,F2RL1,FOS,FOSL1,GADD45A,GBP2,GRB14,HK2,KCNK2,KLF15,KLHL41,LGALS3,MAFF,MAP3K8,MEOX2,MMP16,MYC,NFIL3,NPR3,PDE10A,PLAT,PLAUR,PTGS2,PTX3,SELENBP1,SERPINE1,SOCS3,SPHK1,STAT1,TGM1,TNFAIP6,TNFRSF12A | 417 (16) |
| dexamethasone | NA | chemical drug | Activated | 4.16e+00 | 0.0e+00 | ABCB1,ABCC2,ACKR4,ACTC1,ADAMTS1,ADAMTS15,AKAP6,ALB,ANKRD1,ANXA3,AQP1,ARG2,ATF3,ATF4,ATP10B,ATP1A1,ATP1B1,ATP2B4,B3GNT5,BCL2A1,BCL2L1,BHLHE40,BMP2,BMX,BTG2,C3AR1,CBLB,CCL17,CCL2,Ccl2,CCL4,CCNA1,CCR10,CCR3,CD163,CD22,CD274,CD69,CD83,CDKN1A,CEBPD,CEP70,Ces1f,CIDEA,CLDN5,CMPK2,CPB2,CPT1B,CR2,CRISPLD2,CRP,CTSV,CTSW,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,CYP2S1,Cyp3a25 (includes others),CYSLTR1,DACH1,DDIT4,DIO1,DIO2,DLK1,DLL1,DUSP1,EDEM1,EDN1,EDN3,EDNRA,EGR3,ENC1,EREG,ERRFI1,F2RL1,F3,FAM107A,FANCG,FASN,FCMR,FGA,FGFBP1,FGL1,FKBP5,FOS,FOSL1,FOSL2,FSTL3,FTL,G0S2,GADD45A,GADD45B,GAL,GAS2L2,GBP2,GBP5,GCLC,GEM,GHRHR,GLI1,GLUL,GNAI2,GNRH1,GRINA,GRK5,Gsta1,GZMA,GZMB,H6PD,HEYL,HIPK2,HK2,HLA-DOB,HMOX1,HPCAL1,HSD11B2,HUNK,IER3,IFI44,IFIT1,IFRD1,IL12B,IL1A,IL1R2,IL2RB,IL33,IL4R,IL6R,INHBA,IRS1,ISG15,ITGB7,ITPKC,JAK3,JUNB,KCNK2,KDR,KLF15,KLRD1,KRT17,KRT7,LAG3,LAMA5,LCN2,LGALS12,LGALS3,LIF,LIMK1,LMO4,LOX,LPAR1,LPIN1,LPIN2,LTA,LTB,LYVE1,MAFF,MAOA,MAOB,MAP2K6,MERTK,MGAM,MGP,MMP8,MMP9,MS4A1,Mt1,MX1,MYC,MYCN,NAT8B,NEDD4L,NFIL3,NFKBIA,NGFR,NME5,NPR3,NRTN,NYX,ODC1,P2RY10,P2RY14,P4HA1,P4HA2,PCK1,PDK4,PECR,PER1,PFKFB3,PIK3IP1,PLAT,PLAUR,PNPLA2,Podxl,POR,POU2AF1,PPARA,PPL,PPP1R14D,PRKCB,PTGS2,PTX3,RAB37,RAPGEF4,RBP4,RFX2,RGCC,RGN,RGS16,RSAD2,S100A8,SAT1,SELE,SELENBP1,SELL,SEMA5B,SERPINB1,SERPINE1,SESN1,SFTPB,SHB,SIGLEC8,SLC10A1,SLC10A6,SLC13A3,SLC25A33,SLC2A5,SLC39A10,SLC43A1,SLC5A1,SLC7A6,SLC7A7,Slco1a1,SOAT1,SOCS2,SOCS3,SPECC1,SPHK1,SPOCK1,SPON2,SPSB1,SSBP3,STAT1,SYBU,TBX21,TFPI2,TGFA,TGFBR3,THBS1,TIMP1,TIMP3,TLR5,TMPRSS4,TNFAIP6,TNFRSF18,TNFRSF19,TNFRSF21,TNFSF10,Tnfsf9,TNS4,TRERF1,TRH,TRIM63,TRPM2,TRPM6,TRPV1,Tsc22d3,TXNIP,UBC,UGT2A1,USP18,WNT5A,XCL1,XCR1,ZBTB16,ZC3H12A,ZFP36,ZNF189 | 580 (16) |
| forskolin | NA | chemical toxicant | Activated | 4.14e+00 | 0.0e+00 | Acan,ACER2,ADAMTS1,ADAMTS4,ADGRL2,ADORA2A,AQP3,ATF3,ATP1B1,BHLHE40,BTG2,CAP2,CCL2,CD14,CD163,CD8A,CDKN1A,CEBPD,CREB1,CREM,CRISPLD2,CTSV,CXCL10,CXCL2,CXCL3,CXCR4,DDIT4,DIO2,DUSP1,DUSP9,EDN1,EPHA4,EREG,ERRFI1,EZH2,FKBP5,FOS,FOSL1,FOSL2,GAB2,GADD45A,GADD45B,GADD45G,GAL,GEM,GHRHR,GLI1,GNRH1,GPR3,GRK5,HAS3,HK2,HMOX1,HSD11B2,IER3,INHBA,JAK3,JUNB,LGALS12,MAP1LC3B,MMD,MMP9,Mt1,MYC,MYCN,NFIL3,NFKBIA,NPC2,ODC1,P4HA2,PCK1,PDE4A,PDE4C,PDK4,PDLIM3,PER1,PLAT,PLCL1,Ppp1r15a,PPP1R3C,PPP3R1,PTGS2,PTPRN,RAB20,RAPGEF3,RGS18,S100A8,SAT1,SERPINE1,SFTPB,Sik1,SLC2A5,SLC6A17,SMARCA1,SMIM3,SPRED3,SSTR4,ST8SIA2,STAT1,TFPI2,THBS1,TIMP1,TLE3,TNFAIP6,TRH,TRIB1,TXNIP,UPP1,USP18 | 500 (21) |
| aldosterone | NA | chemical - endogenous mammalian | Activated | 4.13e+00 | 0.0e+00 | ADAMTS1,ATP1A1,ATP1B1,ATP6V0A4,BMP2,CCL2,Ccl2,CIDEA,DUSP1,EDN1,ELL,FKBP5,FOS,FOSL1,FSTL3,IRS1,KCNMB1,KDR,LCN2,LGALS3,LOX,NFKBIA,PER1,PGF,PLAUR,PROCR,PTGS2,SERPINE1,TIMP1,ZBTB16 | 432 (20) |
| PGR | -1.90e-01 | ligand-dependent nuclear receptor | Activated | 4.06e+00 | 0.0e+00 | ADAMTS1,AKAP6,AR,ATP1B1,BCL2L1,CA12,CDH26,CDKN1A,CEBPD,CLDN5,CPT1B,DYNLL1,EDN1,EDNRA,ENC1,F2RL1,F3,FAT2,FKBP5,FLRT3,FOS,FOXC1,GAL,GLUL,HAS3,HDC,HPCAL1,HSD11B2,IER3,IFI44,IFI44L,IFIT1,IL12B,IRS1,ISG15,KCNG1,KCNK1,LIF,LIMK1,LOX,LOXL1,MMP9,MX1,MYC,MYCN,NEDD9,NFKBIA,NGFR,NRP1,OAS2,P4HA2,PCDHB2,Pcdhb6,PDGFB,PFKFB3,PRKCH,PRRX1,PTGS2,RND3,RSAD2,S100A8,SBK2,SELL,SERPINE1,SERPINH1,SLC7A5,STAT1,TBC1D8,TLL1,TNFRSF21,UCK2 | 652 (20) |
| NUPR1 | 1.03e+00 | transcription regulator | Activated | 4.04e+00 | 0.0e+00 | ATF3,B3GNT5,CHTF8,CXCL3,CXCR4,DPYSL5,DUSP8,EPGN,EREG,GAB2,GADD45A,GBP2,HK2,IL6R,LCN2,LIF,MKKS,MMD,MYC,Nes,NFIL3,NGFR,NUPR1,OSBPL6,P4HA2,PCTP,PFKFB3,PXDC1,RAB17,RAB20,RBM14,RCL1,SAT1,SERPINE1,SESN2,SHOX2,SIX4,SLC6A6,SYTL2,TP53BP2,TRERF1,TRIB1,TRIM16,UPP1,WDCP,ZFAND2A | 387 (7) |
| STAT3 | 4.20e-01 | transcription regulator | Activated | 4.03e+00 | 0.0e+00 | ARG2,BCAR3,BCL2L1,BMP2,CCL17,CCL2,Ccl2,CCL4,CD163,CD274,CD40LG,CD83,CDKN1A,CDON,CEBPD,CEP70,CIITA,CMPK2,CREB1,CRP,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DDIT4,DLL1,DUSP1,EDN1,EGR3,F3,FASN,FGA,FLRT3,FOS,GADD45A,GADD45G,GBP2,GBP5,GZMB,HK2,HMOX1,HNF4A,IFI44,IFIT1,IFITM2,Igtp,IKBKE,IKZF3,IL12B,IL1A,IL2RB,IL33,IL4R,IL6R,IRF4,Irgm1,ISG15,JUNB,KDR,Klrk1,KRT17,KRT81,LCN2,LIF,LOX,LTA,MMP9,Mt1,MX1,Mx2,MYC,NFIL3,NRP1,OAS2,PAX5,PCK1,PDGFB,PLAUR,Pmaip1,PRF1,PROCR,PTGS2,PTX3,RSAD2,RTN4RL2,SDC4,SELP,SERPINB1,SERPINE1,SFTPB,SLC28A2,SLC2A5,SLC39A10,SOCS2,SOCS3,SOX2,STAT1,TBX21,TFPI2,THBS1,TIMP1,TNFSF10,Tnfsf9,TNS4,TRH,TRIM14,USP18,WNT5A,ZFP36 | 538 (19) |
| PIK3CG | -3.50e-01 | kinase | Activated | 3.95e+00 | 0.0e+00 | ABCB1,BCL2A1,Ccl2,CD8A,CTSW,CXCL10,CXCR4,FOSL2,GBP2,GBP4,GBP5,GBP7,HMOX1,Igtp,IL12B,IL2RB,Klre1,LCK,OAS2,PRF1,SELE,STAT1,TNFSF10,ZBP1 | 502 (21) |
| Insulin | NA | group | Activated | 3.81e+00 | 0.0e+00 | Acot1,ACTC1,ADH1C,ALB,ARG2,ARRDC3,ATF3,ATP1A1,BCL2L1,CCL2,Ccl2,CCL4,CDKN1A,CEBPD,CIDEA,CREB1,CREB3L3,DDIT4,DLK1,DUSP1,DYNLL1,EDN1,ERRFI1,FABP3,FASN,FGFR4,FOS,FTL,GCLC,GFPT2,GNRH1,GRB14,Gsta1,HIF3A,HK2,HMOX1,HNF4A,HSD11B2,IAPP,INHBA,IRS1,JUNB,KCNJ11,LGALS12,LPIN1,MAOA,MAOB,MMP9,Mt1,MYC,NFIL3,NFKBIA,ODC1,OGT,PCK1,PDHA1,PDK4,PER1,PFKFB3,PLAT,PNPLA2,PPARA,PPARGC1B,PRKCB,PTGS2,PTPRN,RBP4,RGN,SERPINE1,SFTPB,SLC28A1,SLC28A2,SLC2A5,SLC38A2,SLC38A3,SLC6A2,SLC7A1,SOCS2,SOCS3,STAT1,TBX21,TGFA,THBS1,TIMP1,TIMP3,TRIM63,TRPV1 | 537 (24) |
| CG | NA | complex | Activated | 3.77e+00 | 0.0e+00 | ABCB1,ADAMTS1,ADAMTS4,ADAMTS9,ADCYAP1R1,APCDD1,AR,ARHGAP20,ATF4,BCL2L1,BHLHE40,BMP2,BMP6,BTG2,CCL2,Ccl2,CDKN1A,CEBPD,CLDN11,CREB1,CREM,CRISPLD2,CTSV,CXCL10,CXCL3,CXCR4,CYP2R1,CYP7B1,DUSP1,EDN3,ELK3,EREG,F2RL1,F3,FJX1,FKBP5,FOS,FOSL1,FOSL2,G0S2,GADD45B,GAL,GJB2,GNRH1,HK2,HLA-DOB,HSD11B2,HSD17B2,IER3,IL1A,IL1R2,IL33,IL4R,INHBA,JUNB,LIF,LRRN3,MCAM,MMP9,MRO,MYC,NPR3,NR0B2,NR5A2,NRP1,Oasl2,PFKFB3,PKIA,PLAT,PLAUR,PLXND1,PPARA,PTGS2,PTX3,SDC4,SMARCA1,SOCS3,ST8SIA1,TDRD5,TFPI2,TGFBR3,TIMP1,TNFAIP6,TNFRSF12A,TNFRSF21,TRIB1,UPP1 | 610 (18) |
| GPER1 | -4.50e-01 | G-protein coupled receptor | Activated | 3.75e+00 | 0.0e+00 | ATF3,BHLHE40,CDKN1A,CEBPD,DDIT4,DUSP1,EDN1,EREG,ERRFI1,FASN,FOS,MYC,NFKBIA,RGS16,ZFP36 | 649 (22) |
| ETV6-RUNX1 | NA | fusion gene/product | Activated | 3.74e+00 | 0.0e+00 | ABLIM1,APOLD1,ARHGAP4,ARL4D,BCL11A,BLK,BMP2,CD19,CD79A,CD83,CXXC5,CYSLTR1,DDIT4,DLL1,GBP2,GIMAP4,GZMB,IER3,IFIT1,IRF4,ISG15,JAK3,LAT2,LTB,MKNK2,MMP9,MS4A1,Mx2,MYC,NEDD4L,OAS2,PIK3C2B,POU2F2,PSMD9,PTPRC,PTPRCAP,RGS16,RNF144A,RSAD2,SELL,SMIM3,STAT1,STK17B,TDRD5,TNFRSF14,TNFSF10 | 206 (7) |
| F2 | -5.40e-01 | peptidase | Activated | 3.72e+00 | 0.0e+00 | ABCB11,ADAMTS9,B3GNT5,CCL2,Ccl2,CDKN1A,CXCL10,CXCL3,CXCR4,DUSP1,ECE1,EDN1,EREG,F2RL1,F3,FOS,FOSL1,FOSL2,HMOX1,HYAL3,IER3,JUNB,KDR,MEOX1,MMP9,MYC,NFKBIA,PDGFB,PGM2L1,PLAT,PLAUR,PROCR,PTGS2,SDC4,SELE,SELP,SERPINC1,SERPINE1,SLC16A5,SLC7A1,TFPI2,THBS1,TNFRSF12A,TNFSF10,TRPC3,UCK2 | 482 (16) |
| CREB1 | -7.90e-01 | transcription regulator | Activated | 3.68e+00 | 0.0e+00 | ADORA2A,ADRA1A,APOLD1,ARL15,ATF3,ATP1A1,ATP2B4,BCL2L1,BHLHE40,BTG2,CAMK1D,CCL4,CCNA1,CD79A,CDKN1A,CEBPD,CIITA,CPT1A,CR2,CREB1,CREM,CRYM,CSRNP1,CXCL2,CXCR4,CYP46A1,DIO2,DKK2,DUSP1,EDN1,ERRFI1,ESRRG,FASN,FOS,GADD45A,GADD45B,GADD45G,GAL,GEM,GPR3,H2-T22,HMOX1,HPCAL1,IER3,IGSF10,IGSF9B,INHBA,JUNB,LCN2,MCAM,Meis1,MKNK2,MUC5B,MYC,NFIL3,NPC2,Nrgn,NRP1,PCDH20,PCK1,PER1,PGM2L1,PLAT,PTGS2,PTPRN,RASGRF1,RBP4,REM2,RERG,RUNX1T1,SAT1,SEMA7A,SFTPB,Sik1,SMPD3,SOCS2,SPHKAP,SPRED3,ST6GALNAC5,TCEAL9,TRH,UPP1,YPEL1,ZDHHC23,ZFP36,ZFPM2 | 453 (17) |
| cadmium chloride | NA | chemical toxicant | Activated | 3.65e+00 | 0.0e+00 | ALB,AR,ATF4,CRP,FKBP5,FOS,GADD45A,GCLC,HK2,HMOX1,LPAR1,MAFF,Mt1,MYC,PDGFB,PFKFB3,SLC5A1 | 454 (20) |
| filgrastim | NA | biologic drug | Activated | 3.64e+00 | 0.0e+00 | ANXA3,ATF3,ATP1A1,ATP2B4,BCL2L1,BTG2,CCL4,CCNA1,CCR3,CD163,CD69,CD83,CTSW,CXCL10,CXCR4,CYSLTR1,DACH1,EGR3,FCMR,FKBP5,G0S2,GADD45A,GBP5,GRINA,GZMA,GZMB,HIPK2,IFI44,IFIT1,IL1R2,IL2RB,IL4R,ISG15,ITGB7,ITPKC,KLRD1,LGALS12,LGALS3,MAFF,MAP2K6,MERTK,MGAM,MMP8,MMP9,MX1,NME5,P2RY10,P2RY14,PECR,PFKFB3,PLAUR,PTGS2,RAB37,RSAD2,SERPINB1,SIGLEC8,SPECC1,SPON2,SSBP3,STAT1,TLR5,TRERF1,TRPM2 | NA |
| IGF1R | -2.90e-01 | transmembrane receptor | Activated | 3.63e+00 | 0.0e+00 | ANKRD1,ANXA3,BCL2L1,BMP2,CCNA1,CD300C,CD37,CD5L,CD84,CDKN1A,DLK1,EDN1,Elf5,FASN,FOS,GLI1,IL1A,INHBA,IRS1,MYC,MYCN,PECR,PLAT,PTGS2,RBM3,SDC4,TIMP3,TNFSF10 | 524 (21) |
| TREM1 | 2.10e-01 | transmembrane receptor | Activated | 3.56e+00 | 0.0e+00 | ADORA2B,ATF3,ATP1B1,CCL17,Ccl2,CD14,CD274,CD83,CXCL10,CXCL2,CXCL3,CXCR4,EDN1,EGR3,F3,FABP3,FOSL1,GADD45B,GEM,HAS1,IL12B,IL6R,INHBA,ISG15,LIF,MAFF,MAP3K8,NEDD4L,NFKBIA,NRIP3,OSGIN1,PGLYRP1,PTGS2,RGS16,TCEAL9,TFPI2,THBS1,WNT5A | 503 (17) |
| ADAM17 | -3.90e-01 | peptidase | Activated | 3.53e+00 | 0.0e+00 | Ccl2,CDC42EP4,CLDN4,CXCL2,CXCL3,ERRFI1,GADD45G,IL6R,MYCN,NGFR,PGF,PLAT,PPL,SELL,SOCS3,SOX2,WNT5A,WNT7A | 470 (18) |
| EIF2AK3 | 1.70e-01 | kinase | Activated | 3.52e+00 | 0.0e+00 | ATF3,ATF4,BTG2,Ccl2,CD274,EDEM1,ERN1,FOSL1,GADD45A,ICA1,LMO4,MAP1LC3B,MYC,NFIL3,NUPR1,SLC7A1,TXNIP,ZFP36 | 502 (23) |
| HIF1A | -1.60e-01 | transcription regulator | Activated | 3.50e+00 | 0.0e+00 | ABCB1,ADAMTS1,ADORA2B,BCL2L1,BHLHE40,BMP2,CCL2,Ccl2,CCL4,CD274,CD69,CDKN1A,CEMIP,CXCL10,CXCL2,CXCL3,CXCR4,CYP2S1,CYP46A1,DDIT4,ECE1,EDN1,EDNRA,ENO3,EREG,ESRRG,FOS,GADD45B,HIF3A,HK2,HMOX1,IL12B,IL1A,ITGA2B,LOX,LOXL1,MAFF,MMP9,MYC,NFKBIA,NRN1,P4HA1,P4HA2,PDGFB,PDHA1,PFKFB3,PGF,PLAUR,Pln,PPARA,PTGS2,RAB20,RASSF1,RYR2,SDC4,SERPINE1,SESN2,SLC16A3,SLC16A4,SOCS3,SPHK1,STAT1,TGFA,THBS1,TIMP1,TNFSF10,TRIM66 | 419 (15) |
| AGT | -2.60e-01 | growth factor | Activated | 3.50e+00 | 0.0e+00 | Acan,ACTC1,ADAMTS4,ADAMTS5,ADAMTSL2,ADGRE1,ADH1C,ADORA2B,ANXA3,APCS,ATF3,ATP1A1,ATP1B1,ATP6V0A4,BHLHE40,Bhlhe41,BMP2,BMP6,C1QTNF1,CBS/LOC102724560,CCL2,Ccl2,CCL4,CD14,CD300C,CD5L,CDKN1A,CPA2,CREB1,CREM,CRISPLD2,CRP,CTHRC1,CX3CR1,CXCL10,CXCL2,CXCL3,Cyp4a14,DIO2,DISP1,DUSP1,DUSP9,ECE1,EDN1,EDNRA,ENDOU,EREG,ERRFI1,F3,FASN,FGA,FIBIN,FKBP5,FOS,FOSL1,FRAT2,GFI1,GRK5,HHIPL1,HMOX1,IL1A,IRS1,ITGA7,ITGB7,KDR,KLF15,LCN2,LGALS3,LGI3,LIF,LOX,LOXL1,LTA,MKNK2,MMP8,MMP9,MYC,NAT8B,Nes,NFKBIA,NPR3,PCYOX1L,PDGFB,PDGFD,PGF,Pln,PLXNA4,PNKD,PPP1R3C,PTGS2,PTPRC,RASGRF1,RASGRP1,RBP4,Rcan1,RYR2,S100A8,SELE,SELL,SERPINE1,SLC10A6,SLC5A1,SLC6A2,SOCS3,Spry1,TGFA,THBS1,TIMP1,TNFRSF12A,TNFRSF18,TNFRSF19,TXNIP,WIPF3,ZEB2,ZFP36 | 539 (18) |
| nelfinavir | NA | chemical drug | Activated | 3.49e+00 | 0.0e+00 | ATF3,ATF4,HHIPL1,HMOX1,LONRF1,LURAP1L,MMP9,NFIL3,NUPR1,PSAT1,SESN2,SYBU,TGM1 | 292 (7) |
| YBX1 | 1.20e-01 | transcription regulator | Activated | 3.49e+00 | 0.0e+00 | ABCB1,AQP1,BCL2L1,Ccl2,CDKN1A,CIRBP,CXCL2,DCLK3,EPHA2,EREG,F3,FOS,IL1A,LGALS3,MUC13,MYC,PDGFB,PLAUR,PTGS2,TRIM14 | 465 (18) |
| GNAS | -1.10e-01 | enzyme | Activated | 3.48e+00 | 0.0e+00 | ADAMTS1,ARL4D,ATF3,ATP1A1,BCL2L1,BTLA,CCL2,Ccl2,CD22,CIITA,CREM,CXCL2,FASN,FCER2,FOS,FOSL2,GADD45G,GEM,GLI1,MAFF,MYC,NRP1,P2RY10,PDE4A,PRKCB,RAPGEF4,RNASE6,THBS1,TRIB1,UCK2 | 471 (20) |
| semaxinib | NA | chemical drug | Activated | 3.48e+00 | 0.0e+00 | ATF3,CCL19,Ccl2,CCR6,CCR9,CD28,CD3G,CD40LG,CD8A,CLEC10A,CX3CR1,CXCL10,CXCL2,CXCL3,EDN1,EREG,F3,FOS,HMOX1,IL1R2,IL21R,IL2RB,IRF4,ITIH4,KDR,LCK,LCN2,MMP9,MYOCD,NFKBIA,PTGS2,PTX3,RASGRP1,SELE,SEMA6B,SERPINE1,SLAMF6,SOCS3,THBS1,TLR5,TNFRSF14,TNFRSF18 | 434 (18) |
| TGFA | 1.39e+00 | growth factor | Activated | 3.45e+00 | 0.0e+00 | ALB,BCL2L1,CCL2,CDKN1A,CXCL10,CXCL2,EREG,ERRFI1,FOS,FOSL2,GJB1,GJB2,JUNB,LCN2,MMP9,PLAT,PTGS2,SERPINE1,TGFA,TLR5,WNT5A | 634 (23) |
| Pdgf (complex) | NA | complex | Activated | 3.42e+00 | 0.0e+00 | CCL2,Ccl2,CDKN1A,CXCL3,EDN1,ERRFI1,F10,F3,FOS,HMOX1,INHBA,JUNB,MEOX2,MYC,ODC1,PLAUR,PTGS2,SERPINE1,TIMP1,TIMP3 | 418 (17) |
| dalfampridine | NA | chemical drug | Activated | 3.41e+00 | 0.0e+00 | ATF3,BTG2,DUSP1,FOS,GADD45B,GADD45G,HK2,JUNB,KCNA5,MAFF,PFKFB3,PTGS2 | 458 (19) |
| bicuculline | NA | chemical - endogenous non-mammalian | Activated | 3.39e+00 | 0.0e+00 | ATF3,BTG2,DUSP1,FOS,GADD45B,GADD45G,GNRH1,HK2,JUNB,MAFF,PFKFB3,PTGS2 | 478 (19) |
| triamterene | NA | chemical drug | Activated | 3.38e+00 | 0.0e+00 | ADAMTS1,CD14,CLDN4,Ctla2a,FGA,IER3,LCN2,LGALS3,MYC,PLA1A,RBM3,RCN1,TIMP1,TNFRSF12A,UPP1 | NA |
| KLF6 | 4.60e-01 | transcription regulator | Activated | 3.36e+00 | 0.0e+00 | ATF3,BCL2L1,BMP2,CCL2,Ccl2,CCL24,CD274,CD83,CDKN1A,CXCL2,CXCL3,DLK1,F10,GADD45B,GCLC,GFPT2,GLI1,HK2,HMOX1,HNF4A,IL12B,IL1A,IRAK2,JUNB,LGALS3,LPAR1,MCCC2,MMP9,MYC,NFKBIA,OSMR,P4HA2,PFKFB3,PLAT,PPARA,PTGS2,SELE,SERPINH1,SLC16A3,SOCS3,SPSB1,TFPI2,TIMP1,UPP1,ZC3H12A | 425 (17) |
| ceruletide | NA | biologic drug | Activated | 3.35e+00 | 0.0e+00 | ATF4,Ccl2,CDC42EP4,CLDN4,CXCL2,CXCL3,ERRFI1,GADD45G,HMOX1,IL33,IL6R,PGF,PPL,PTGS2,SELP,SOCS3 | 369 (17) |
| thapsigargin | NA | chemical toxicant | Activated | 3.34e+00 | 0.0e+00 | ABCB1,Acan,AR,ATF3,ATF4,BCL2L1,Ccl2,CD83,CDKN1A,CLDN4,COL2A1,CPT1A,CREM,CXCL10,CXCL2,CXCL3,DDIT4,DIO2,EDEM1,ERN1,ERRFI1,FOS,GADD45A,GADD45B,HDC,HMOX1,LPIN1,MLF1,MMP9,MYC,NEDD4L,NFIL3,NFKBIA,NR0B2,SESN2,SFN,THBS1,TNFSF10,TXNIP,TXNRD1,UPP1 | 521 (20) |
| dexamethasone phosphate | NA | chemical drug | Activated | 3.32e+00 | 0.0e+00 | Arrdc2,CXCR4,DDIT4,DUSP1,ERRFI1,GADD45G,LYVE1,Mt1,NFKBIA,PDK4,THBS1 | 240 (7) |
| diclofenac | NA | chemical drug | Activated | 3.31e+00 | 0.0e+00 | ATF3,ATF4,CDKN1A,CLDN4,CRP,FOS,IL1A,IL24,KCNA3,LGALS3,MAP1LC3B,MYC,OSMR,PSAT1,PTGS2,SELL,SERPINE1,SLC38A2,SLC7A1,TNFRSF12A | 464 (20) |
| EP4-D | NA | chemical reagent | Activated | 3.30e+00 | 0.0e+00 | ABCB1,CCL19,CD27,CD3G,GCLC,GZMA,HSH2D,IKBKE,IKZF3,IL12B,IL2RB,IL33,LCK,LTA,PRF1,SLAMF6,SPN,ZBTB16 | NA |
| ciprofibrate | NA | chemical drug | Activated | 3.29e+00 | 0.0e+00 | ABCB1,ABCB11,ADAMTS1,APCS,APOB,BAAT,C9,CIDEA,CRP,CTSV,Cyp3a25 (includes others),Cyp4a14,CYP7B1,DIO1,FGA,LCN2,NFKBIA,NPC2,PDK4,PEX11A,PIPOX,RBM3,RGN,SELENBP1,SLC10A1,Slco1a1 | 518 (21) |
| EGF | 4.20e-01 | growth factor | Activated | 3.29e+00 | 0.0e+00 | ACTC1,ADAMTS1,AQP3,AR,ATF3,AURKB,BCL2L1,BTG2,CCL17,CCL2,Ccl2,CD274,CDKN1A,CEBPD,CPB2,CREM,CXCL2,CXCL6,CXCR4,DIO2,DUSP1,EDN1,EGR3,EPGN,EPHA2,ERBB3,EREG,ERRFI1,F3,FASN,FOS,FOSL1,FOSL2,GAB2,GADD45A,GAL,GFPT2,GLUL,HAS3,HMOX1,HNF4A,IAPP,IER3,IFITM2,IL1R2,INHBA,IRS1,JUNB,LCN2,MAOA,MMP9,MUC5B,MYC,MYCN,Nes,NEXN,NR5A2,NRP1,ODC1,OSR2,PBK,PDK4,PER1,PGF,PLAT,PLAUR,Podxl,PRKCH,PTGS2,PTPRN,SERPINE1,SOCS3,SOX2,SPHK1,STAT1,TFPI2,TGFA,TGM1,THBS1,TIMP1,TIMP3,TNFRSF12A,TRH,WNT7A,ZFP36 | 463 (17) |
| cisplatin | NA | chemical drug | Activated | 3.28e+00 | 0.0e+00 | AADAT,ABCB1,ABCC2,ABL1,ADAMTS1,ADGRE1,ALB,ANKRD1,AQP1,AQP3,ATF3,ATF4,BCL2A1,BCL2L1,BTG2,CCL2,Ccl2,CCL28,CD14,CDKN1A,CDO1,CHST7,CLCA1,CLDN4,CPT1A,CPT1B,Ctla2a,CXCL10,CXCL3,DDIT4,DPYSL5,DUSP1,ECE1,EDN1,ERBB3,EZH2,F3,FASN,FGA,FLRT3,FOS,FOSL1,G0S2,GADD45A,Gsta1,HEYL,HIPK2,HK2,HMOX1,HSPA4L,IER3,IL1A,IL4R,INHBA,ITGA7,KCNK5,KLF12,LCN2,LGALS3,LMO4,LPIN1,MAOA,MAP1LC3B,MCAM,MGP,MLF1,Mt1,MX1,MYC,MYCN,NFKBIA,NR0B2,ODC1,P4HA2,PCDH20,PDE4A,PDK4,PLA1A,PLAT,Pmaip1,PPARA,PPP3R1,PROCR,PTGS2,PTPRO,RBM3,RBP4,RCN1,RGN,S100A8,SAT1,SCN4B,SEMA7A,SERPINE1,SESN1,SESN2,SLC10A1,SLC6A6,SLC7A6,Slco1a1,SOCS3,SOX2,SPEG,SPON2,STK17B,THBS1,TIMP1,TIMP3,TNFRSF12A,TNFRSF14,TNFSF10,TP73,TRPM6,TRPV1,TXNIP,UPP1,XDH | 596 (18) |
| FOXO3 | 5.00e-01 | transcription regulator | Activated | 3.25e+00 | 0.0e+00 | Acan,Acot1,ANXA3,AR,BMP2,CCNA1,CD163,CDKN1A,CTSV,CXCL10,CXCR4,DDIT4,FASN,FOS,FOXC1,GABARAPL1,GADD45A,GADD45B,GCLC,GLUL,GRB14,IER3,INHBA,IRS1,JUNB,LCN2,MAP1LC3B,MCAM,MMP9,Mt1,MYC,MYOCD,NFKBIA,NRP1,NUPR1,PBK,PIK3IP1,PTPRC,Rcan1,SELL,SERPINB1,SERPINE1,SESN1,SIX4,SLC7A1,SOX2,TNFSF10,TRIM63,TXNIP,UBC | 576 (22) |
| arsenite | NA | chemical toxicant | Activated | 3.22e+00 | 0.0e+00 | ABCB1,ATF4,CDKN1A,CXCL3,DUSP1,EREG,FOS,GADD45A,GCLC,HMOX1,HSPA4L,IER3,INHBA,MAFF,MYC,PPP1R3C,PTGS2,SERPINE1,SLC38A2,THBS1,TXNRD1 | 477 (17) |
| ERK | NA | group | Activated | 3.21e+00 | 0.0e+00 | ARG2,BCAR3,BCL2L1,BTG2,CCL2,Ccl2,CCL4,CDKN1A,CEBPD,CLDN4,CXCL10,CXCL2,CXCL6,DIO2,DUSP1,EDN1,EPHA2,EREG,EZH2,FOS,FOSL1,FOSL2,GCLC,HAS1,HAS3,HMOX1,IER3,IL12B,IRS1,ITGA2B,JUNB,KYNU,LCN2,LIF,MAFF,MCAM,MMP9,MS4A1,MYC,ODC1,PDK4,PTGS2,SELL,SERPINE1,SFN,SFTPB,STAT1,TBX21,TGFA,THBS1,TIMP1,TRPC3,ZFP36 | 494 (19) |
| collagenase | NA | group | Activated | 3.21e+00 | 0.0e+00 | Ccl2,CCL4,CEBPD,CXCL10,CXCL2,CXCL3,CXCL6,FOSL1,IER3,IL1A,JUNB,PTX3,SELE,SELP | 437 (11) |
| vancomycin | NA | biologic drug | Activated | 3.20e+00 | 0.0e+00 | ADAMTS1,AK1,Bhlhe41,BMP6,BMP7,CD14,CD69,CLDN4,CMPK2,Ctla2a,CXCL2,FGA,FOS,HMOX1,IER3,JUNB,KHDRBS3,LAG3,LCN2,LGALS3,MYC,PLA1A,RBM3,RCN1,SEZ6L,SOCS2,TIMP1,TNFRSF12A,UPP1 | 350 (14) |
| NR3C2 | -3.00e-01 | ligand-dependent nuclear receptor | Activated | 3.19e+00 | 0.0e+00 | ADAMTS1,ATP1B1,BCL2A1,BCL2L1,CCL2,Ccl2,Cmya5,CXCL6,CXCR4,DDIT4,EDN1,FKBP5,INHBA,JUNB,KDR,LCN2,MLF1,NRIP3,PGF,PLAT,PROCR,PTGS2,PTPRCAP,PTX3,RAPGEF4,SERPINE1,SPHK1 | 490 (17) |
| cigarette smoke | NA | chemical toxicant | Activated | 3.17e+00 | 0.0e+00 | ATF4,BCL2L1,CCL2,Ccl2,CDKN1A,CXCL10,CXCL2,CXCL3,CXCL6,DDIT4,DNAJB5,ERN1,FOS,FOSL1,FTL,GADD45G,GCLC,HAS3,HMOX1,IL1A,IRAK2,KDR,LCN2,MAFF,MAP1LC3B,MMP9,MX1,NFKBIA,OAS2,Oasl2,PDGFB,PGF,POU2AF1,PPARA,PTGS2,RAPGEF3,SERPINE1,TCN2,TIMP1,TRIM63,TXNRD1,UBC,WNT5A,XDH | 513 (20) |
| tunicamycin | NA | chemical - endogenous non-mammalian | Activated | 3.11e+00 | 0.0e+00 | ABCB1,Acan,ADCYAP1R1,ATF3,ATF4,Ccl2,CDKN1A,CEBPD,CLDN5,COL2A1,CPT1A,CXCL2,CXCL3,Cyp4a14,DDIT4,EDEM1,ERBB3,ERN1,FASN,GADD45A,GADD45B,HMOX1,ICA1,IFRD1,IL1A,LPIN1,MMP9,MYC,NEDD4L,NFIL3,NFKBIA,PPARA,PTGS2,SESN2,SLC7A1,SOCS3,TGFA,TXNIP | 507 (22) |
| fenamic acid | NA | chemical reagent | Activated | 3.10e+00 | 0.0e+00 | ABCC2,ADAMTS1,CD14,CLDN4,Ctla2a,FGA,IER3,LCN2,LGALS3,MYC,PLA1A,RBM3,RCN1,SELL,TIMP1,TNFRSF12A,UPP1 | NA |
| 2-bromoethylamine | NA | chemical reagent | Activated | 3.05e+00 | 0.0e+00 | ABCC2,ADAMTS1,CD14,CLDN4,Ctla2a,IER3,LCN2,LGALS3,MYC,PLA1A,RBM3,TIMP1,TNFRSF12A,UPP1 | NA |
| MYO6 | -1.40e-01 | other | Activated | 3.05e+00 | 0.0e+00 | ARL4D,ATF3,DUSP1,EGR3,ERRFI1,GAB2,GRB14,IER3,LPIN1,MAP3K8,SCIN,SDC4,VGLL3 | 295 (7) |
| trovafloxacin | NA | chemical drug | Activated | 3.00e+00 | 0.0e+00 | BHLHE40,CDKN1A,CXCL2,CXCL3,ERRFI1,FASN,FOS,GCLC,HMOX1,Igtp,JUNB,MAP3K8,NEDD4L,NFKBIA,SELE,SERPINE1,SOCS2,SOCS3,THBS1 | 508 (13) |
| Growth hormone | NA | group | Activated | 2.99e+00 | 0.0e+00 | ALB,BMP2,BMP7,CEBPD,CXCL2,Cyp4a14,DLK1,FASN,FKBP5,FOS,FOSL2,GCLC,GHRHR,Gsta1,IER3,JUNB,MMP9,MYC,NEDD9,NFKBIA,PCK1,PDK4,PFKFB3,PIK3C2B,PON1,PPARA,SOCS2,SOCS3,TNFSF10,TXNIP,XDH,ZEB2 | 564 (23) |
| IL17A | NA | cytokine | Activated | 2.96e+00 | 0.0e+00 | BCL2A1,BCL2L1,CCL17,CCL2,Ccl2,CCL4,CD14,CD163,CD274,CD83,CEBPD,COL2A1,CRP,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,CYP7B1,EREG,FOS,FOSL1,GADD45A,GBP2,IL12B,IL1A,IL24,IL33,ISG15,KRT17,LCN2,LIF,LOX,MERTK,MMP8,MMP9,MYC,NRP1,OSMR,PGF,PLAT,PPARA,PTGS2,RGS16,S100A8,SELE,SELP,SERPINE1,SOCS3,SPSB1,STAT1,TBX21,TGFA,TIMP1,TIMP3,TNFRSF14,ZC3H12A | 483 (14) |
| Lh | NA | complex | Activated | 2.95e+00 | 0.0e+00 | ADAMTS1,AR,Bhlhe41,CAP2,CDC42EP4,CREB1,CXCR4,DUSP1,DUSP9,EREG,FGFR4,FKBP5,FOS,GADD45B,GADD45G,GEM,GNRH1,GRK5,HK2,JUNB,MAP1LC3B,MMP9,MYC,NPC2,OSBPL6,P4HA2,PDLIM3,PER1,PLAT,PLCL1,PPP3R1,PTGS2,PTPRN,PTX3,RAPGEF3,RGS16,Sik1,SLC16A3,SLC7A1,SNAP23,STAT1,TFPI2,THBS1,THRB,TNFAIP6,TNFRSF12A,TRIB1,UPP1,ZBTB16 | 643 (21) |
| lysophosphatidic acid | NA | chemical - other | Activated | 2.93e+00 | 0.0e+00 | ANKRD1,CCL2,Ccl2,CCL4,CD14,CXCL10,CXCL2,CXCL3,DUSP1,EDN1,F3,FKBP5,FOS,JUNB,KDR,LIF,MMP9,MYC,PCK1,PLAUR,PRKCG,PTGS2,SERPINE1,SLC26A3,SPHK1,WNT5A | 443 (17) |
| Wy 40905 | NA | chemical reagent | Activated | 2.93e+00 | 0.0e+00 | AR,ATF3,BTG2,CDKN1A,CIDEA,CREM,FOS,FOSL1,GADD45B,JUNB,PER1,RFX2,SCN1B,SERPINE1,ZFP36 | 480 (20) |
| SN-011 | NA | chemical reagent | Activated | 2.93e+00 | 0.0e+00 | CCL2,CD274,CDKN1A,CXCL10,GBP4,GBP5,IFI44,IKBKE,ISG15,OAS2,RSAD2,STAT1,TNFSF10,TRIM14,UBA7,USP18,ZBP1 | NA |
| isoproterenol | NA | chemical drug | Activated | 2.91e+00 | 0.0e+00 | ABL1,ADCY5,ATF3,ATP1A1,BVES,Ccl2,CREM,DIO2,EDN1,FOS,FOSL1,FOSL2,GPR3,GRK5,HMOX1,JUNB,LGALS12,LGALS3,LIF,MERTK,MMP9,MYOCD,ODC1,PCK1,PDGFB,PLAT,Pln,PNPLA2,PTGS2,TGFBR3,TIMP1 | 467 (20) |
| LDL | NA | complex | Activated | 2.90e+00 | 0.0e+00 | ARG2,ATF3,BCL2A1,BCL2L1,BMP2,CBS/LOC102724560,CCL2,Ccl2,CCL4,CD40LG,CDKN1A,CREM,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,DUSP1,ECE1,EGR3,F3,FASN,FOS,G0S2,GCLC,HAS3,HMOX1,IL12B,IL1A,LTA,MMP16,MMP8,MMP9,MX1,NPC2,NR0B2,NRP1,OSBPL6,PLAT,PTGS2,RND3,RYR2,S100A8,SELE,SELP,SERPINE1,SOCS3,SPHK1,TGFBR3,TNFAIP6,TNFSF10 | 476 (15) |
| puromycin aminonucleoside | NA | chemical reagent | Activated | 2.90e+00 | 0.0e+00 | ABCC2,ADAMTS1,ALB,AQP1,CD14,CLDN4,Ctla2a,CTSV,FGA,IER3,LCN2,LGALS3,MYC,PLA1A,RBM3,RCN1,TIMP1,TNFRSF12A,UPP1 | NA |
| doxorubicin | NA | chemical drug | Activated | 2.89e+00 | 0.0e+00 | ABCB1,ACTC1,ADAMTS1,ADORA2B,ALB,AR,ARVCF,ATF3,AURKB,BCL2A1,BCL2L1,BHLHE40,BMP3,BTG2,CCL2,Ccl2,CCR9,CD14,CD274,CDKN1A,CLDN4,CREM,Ctla2a,CXCL10,CXCL2,CXCL3,CXCL6,DDIT4,DUSP1,EDN1,ERN1,F3,FGA,FGF11,FGFBP1,FOS,GADD45A,GCLC,HIPK2,HMOX1,IER3,INHBA,JPH2,KCNJ4,LCN2,LGALS3,LPIN1,MYC,NFKBIA,ODC1,OSGIN1,PLA1A,PLAUR,PLG,Pmaip1,Podxl,PTGS2,RBM3,RCN1,RGS16,RYR2,S100A8,SESN1,SFN,SLC6A6,SPHK1,STAT1,TBC1D8,TGFA,TIMP1,TNFRSF12A,TNFRSF14,TNFRSF18,TNFRSF21,TNFSF10,TNFSF8,TP53BP2,TP73,TRIM63,UPP1,XDH | 510 (16) |
| FGF2 | 3.90e-01 | growth factor | Activated | 2.88e+00 | 0.0e+00 | ACER2,ACTC1,ADAMTS5,ADGRL2,ALB,AQP1,AQP3,AR,ATF4,BCL2L1,BMP2,BTG2,CCL2,Ccl2,CD274,CDKN1A,Chrm2,CXCL2,CXCL6,CXCR4,DKK2,DLL1,EPHA4,EREG,ERRFI1,F3,FGFR4,FOS,FOSL1,GADD45A,GAL,GLI1,GNRH1,GRIK4,HK2,IAPP,IFITM2,INHBA,IRS1,JUNB,KDR,LOX,LYVE1,MCAM,Meis1,MEOX2,MGP,MMD,MMP9,MYC,MYCN,Nes,NGFR,NR5A2,ODC1,PDGFB,PGF,PLAT,PLAUR,Podxl,PTGS2,S100A8,SELE,SERPINE1,SMIM3,SOCS3,SOX2,SPHK1,TGFBR3,THBS1,TIMP1,TIMP3,TNFRSF12A,TNFSF10,WNT5A,ZEB2 | 484 (16) |
| trinitrobenzenesulfonic acid | NA | chemical reagent | Activated | 2.87e+00 | 0.0e+00 | ABCB11,ABCC2,Ccl2,CCL24,CCL4,CXCL10,CXCL2,CXCL3,CXCL6,FOS,IL12B,IL1A,IL1R2,LCN2,MMP9,NR0B2,PTGS2,PTX3,S100A8,SLC10A1,Slco1a1,SOCS3,TBX21,TIMP1,TNFRSF12A | 505 (19) |
| NRG1 | -1.60e-01 | growth factor | Activated | 2.86e+00 | 0.0e+00 | ANKRD1,AR,ATF4,BCL2L1,CDKN1A,CXCL6,CXCR4,DUSP1,EDN1,EGR3,ENO3,EPHA2,ERBB3,ERRFI1,FOS,FOSL1,HK2,HMOX1,IER3,JUNB,LMO4,MMP9,MYC,PHKG1,PLAUR,PLG,PTGS2,SELE,SERPINE1,SOX2,THBS1,ZFP36 | 467 (18) |
| EPO | NA | cytokine | Activated | 2.86e+00 | 1.0e-02 | ADAMTS10,BCL2L1,CCL19,CDKN1A,CXCR4,EDN1,EDN3,FOS,GLUL,JUNB,KCNH6,KCNV2,MYC,NFKBIA,NUPR1,PIK3IP1,Podxl,PRKCB,PTGS2,SELE,SELP,SNAP23,SOCS2,SOCS3,TNFSF10,TXNIP,ZFHX2 | NA |
| gentamicin C | NA | chemical drug | Activated | 2.85e+00 | 0.0e+00 | ABCC2,ADAMTS1,CD14,CLDN4,Ctla2a,FGA,IER3,LCN2,LGALS3,MYC,PLA1A,RBM3,TIMP1,TNFRSF12A,UPP1 | NA |
| lomustine | NA | chemical drug | Activated | 2.84e+00 | 0.0e+00 | ABCC2,CD14,CLDN4,Ctla2a,FGA,IER3,LCN2,LGALS3,MYC,PLA1A,RBM3,RCN1,TIMP1,TNFRSF12A,UPP1 | NA |
| tosedostat | NA | chemical drug | Activated | 2.83e+00 | 0.0e+00 | ATF3,CBS/LOC102724560,CDKN1A,DDIT4,GADD45A,PSAT1,SESN2,SLC38A2 | NA |
| Scd2 | 4.00e-02 | enzyme | Activated | 2.83e+00 | 0.0e+00 | CMPK2,F830016B08Rik,GBP7,HDC,ISG15,OAS2,RSAD2,ZBP1 | 315 (11) |
| SMAD3 | -1.40e-01 | transcription regulator | Activated | 2.82e+00 | 0.0e+00 | ADAMTS1,ADAMTS5,ADORA1,ALB,ANKRD1,APOB,ATF4,BMP2,BMP6,CCL2,Ccl2,CCL4,CD79A,CDH6,CDKN1A,CIITA,COL2A1,CPT1B,CRISPLD2,CRP,CXCL10,CXCL3,EDN1,EREG,FASN,FNDC5,FOS,FSTL3,GADD45B,GLI1,GZMA,GZMB,HMOX1,HNF4A,IL12B,JUNB,LOX,LPAR1,MMP9,MYC,PDGFB,POR,PTGS2,PTX3,SERPINE1,SFTPB,SOX2,SPHK1,TBX21,TGFA,THBS1,TIMP1,TIMP3,ZEB2,ZFP36 | 495 (18) |
| fluticasone propionate | NA | chemical drug | Activated | 2.82e+00 | 0.0e+00 | CCL2,CD163,CD83,CRP,CXCL10,CXCL2,DDIT4,FCN1,FKBP5,GADD45B,GAL,GBP5,GJB2,IFIT1,IL1A,IL1R2,ITGB7,MERTK,MMP9,MX1,OAS2,PDK4,S100A8,SDC4,SERPINE1,SESN1,SLC2A5,STAT1,TBC1D16,TCN2,THBS1,TIMP1,TIMP3 | 515 (20) |
| NCF1 | -2.90e-01 | enzyme | Activated | 2.81e+00 | 0.0e+00 | Ccl2,CD14,CDKN1A,EDN1,F3,HMOX1,HYAL3,ISG15,SERPINE1,STAT1,TNFRSF14 | 497 (18) |
| EDN1 | 1.10e+00 | cytokine | Activated | 2.80e+00 | 0.0e+00 | BCL2A1,CALCRL,CCL2,CXCR4,EDN1,EDN3,EDNRA,EREG,ERRFI1,FABP3,FOS,FOSL1,HCN4,INHBA,JUNB,MCAM,MMP9,MYC,ODC1,PLAUR,PPARA,PRKCB,PTGS2,RAMP3,SELE,SELL,SERPINE1,SOCS3,THBS1,TIMP1,TIMP3 | 511 (20) |
| phenylbutazone | NA | chemical drug | Activated | 2.80e+00 | 0.0e+00 | ABCC2,ADAMTS1,CLDN4,Ctla2a,IER3,LCN2,LGALS3,PLA1A,PTGS2,RBM3,RCN1,TIMP1,TNFRSF12A,UPP1 | 312 (7) |
| SERPINE1 | 8.00e-01 | other | Activated | 2.75e+00 | 0.0e+00 | Acot1,ALDH8A1,ANKRD1,CD14,CDKN1A,CXCL10,CXCL2,CXCL3,CXCL6,DLK1,DUSP1,FOS,IER3,IL12B,JUNB,MAP3K8,NFKBIA,PLAUR,PLG,PRF1,SPON2,ZFP36 | 424 (18) |
| acetaminophen | NA | chemical drug | Activated | 2.73e+00 | 0.0e+00 | ABCB1,ABCB11,ABCC2,ACOX2,ALB,BTG2,Ccl2,CDKN1A,CRP,CTSV,CXCL10,CXCL2,CXCL3,FTL,GADD45A,GCLC,GJB1,GLUL,HMOX1,IFRD1,IL1A,IRS1,KDR,Mt1,MYC,NGFR,ODC1,PLAUR,PNPLA2,PPARGC1B,PRKCB,PTGS2,SLC10A1,Slco1a1,SOCS3,TXNRD1 | 505 (18) |
| G-1 | NA | chemical reagent | Activated | 2.73e+00 | 0.0e+00 | AR,CCNA1,EREG,FASN,FOS,PFKFB3,PTGS2,PTX3,TNFAIP6 | 556 (24) |
| IL4 | NA | cytokine | Activated | 2.72e+00 | 0.0e+00 | ABLIM1,ADAMTS4,ADGRE1,ADORA2A,ADORA2B,APOLD1,ARG2,ARID5A,BCL11A,BCL2L1,BHLHE40,BPIFB1,CAMK1D,CCL17,CCL2,Ccl2,CCL24,CCL4,CCR3,CCR6,CCR9,CD14,CD163,CD22,CD274,CD40LG,CD69,CD79A,CD79B,CD83,CD8A,CDKN1A,CHST3,CHST7,CIITA,CLDN5,CLEC10A,CMPK2,CR2,CRISPLD2,CSF3R,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,CYSLTR1,DDIT4,DNASE1L3,EBNA1BP2,EPHA2,F2RL1,F3,FASN,FCER2,FKBP5,FOS,GADD45B,GADD45G,GBP2,GBP5,GBP7,GFI1,GJB1,GZMA,HDC,HIPK2,HK2,HSH2D,IER3,IFI44,IFI44L,IFIT1,Igtp,IL12B,IL1A,IL1R2,IL24,IL2RB,IL33,IL4R,IRAK2,IRF4,Irgm1,ISG15,ITGB7,JAK3,JUNB,KCNG1,KCNH1,KCNK1,KLRD1,Klrk1,KRT7,LAG3,LGALS3,LIF,LPIN2,LRRC32,LTA,LTB,MAOA,MAPKAPK3,MERTK,MMP9,MS4A1,MUC5B,MYC,NEDD9,NFIL3,NFKBIA,NOCT,Nrgn,NRP1,OAS2,ODC1,PAX5,PCYOX1L,PIK3C2B,PLCD1,POU2AF1,POU2F2,PPARGC1B,PRF1,PRSS22,PTGS2,PTPRCAP,RAMP3,Retnlg,RNF213,S100A8,SELE,SELL,SELP,SEMA7A,SERPINE1,SLC16A3,SLC23A1,SLC7A5,SOCS2,SOCS3,SOX2,SPHK1,SPN,STAT1,TBX21,TIMP1,TIMP3,TINAGL1,TNFAIP6,TNFRSF14,TNFRSF18,TNFRSF8,TNFSF18,TNFSF8,Tnfsf9,TPBG,UPP1,USP18,VIPR2,WNT11,XCL1,ZBP1,ZC3H12A,ZFP36 | 570 (17) |
| kainic acid | NA | chemical toxicant | Activated | 2.72e+00 | 0.0e+00 | ALB,APOLD1,ATF3,ATF4,BCL2L1,BTG2,Ccl2,CREM,CSRNP1,CUBN,DUSP1,EGR3,ERRFI1,FOS,FOSL1,FOSL2,GADD45B,GRIK4,HDC,JUNB,KDR,LCN2,MMP9,NFIL3,NGFR,ODC1,PER1,PLAT,PLAUR,PTGER3,PTGS2,Sik1,SIX1,TIMP1 | 499 (23) |
| KCNJ10 | -3.80e-01 | ion channel | Activated | 2.71e+00 | 0.0e+00 | ANXA3,Ccl2,CXCL10,FOSL1,GADD45A,GBP5,LGALS3,Pmaip1,TGM1,TIMP1,TNFRSF12A | NA |
| ZFTA-RELA | NA | fusion gene/product | Activated | 2.71e+00 | 0.0e+00 | BCL2L1,BMP2,Ccl2,CXCL10,CXCL2,CXCL3,IL4R,NFKBIA,PDGFB,PTGS2,SDC4 | NA |
| carrageenan | NA | chemical drug | Activated | 2.70e+00 | 0.0e+00 | Ccl2,CXCL2,CXCL3,F2RL1,FOS,FOSL1,FOSL2,JUNB,NFKBIA,PTGS2,SELP,TRPM2,Tsc22d3 | 399 (13) |
| RAS | NA | group | Activated | 2.69e+00 | 0.0e+00 | ARG2,BCL2L1,CCL2,CD274,CDKN1A,CLDN4,CSF3R,CXCL10,EDN1,FOS,FOSL1,GBP2,HMOX1,IL1A,IL24,LIF,MAOB,MMP9,MUC5B,MYC,ODC1,PDGFB,PLAUR,PTGS2,SERPINE1,STAT1,TFPI2,UPP1 | 437 (16) |
| 4-hydroxytamoxifen | NA | chemical drug | Activated | 2.67e+00 | 0.0e+00 | ABCB1,ACTC1,AQP3,ATF3,BCL2L1,BHLHE40,CCNA1,CDCA7,CDKN1A,CEBPD,CLDN4,DDIT4,DUSP1,DUSP9,DYNLL1,EDN1,ERRFI1,FOS,FOSL2,IER3,JUNB,MYC,NEDD9,NFKBIA,OGT,PDK4,PDLIM3,PRKCH,RBP4,RGS16,SPHK1,TGFA,THRB,TRIM16,ZFP36 | 522 (21) |
| RC3H1 | NA | enzyme | Activated | 2.67e+00 | 0.0e+00 | CCL2,CCL24,CCL4,CCR6,CXCL2,CXCL6,EDN1,FOSL1,IFI44,IFI44L,IFIT1,IL1A,ISG15,MX1,NRP1,OAS2,RSAD2,STAT1,WNT5A | 500 (17) |
| NGEF | 2.00e-02 | other | Activated | 2.67e+00 | 0.0e+00 | BBOX1,BCL11B,CAMK1D,CIITA,COL2A1,CXCR4,CYP26B1,ESRRG,IFI44L,LPAR1,MX1,NR0B2,RAPGEF4,TNFSF10 | NA |
| ethanol | NA | chemical - endogenous mammalian | Activated | 2.66e+00 | 0.0e+00 | ADCYAP1R1,ADH1C,ATF3,ATF4,BCL2L1,C3AR1,C9,CCL2,Ccl2,CD14,CD40LG,CDKN1A,CEBPD,CPT1A,CREB1,CREB3L3,CRP,CXCL3,CXCR4,CYP7B1,DUSP1,EDN1,EZH2,FASN,FOS,FOSL1,FOSL2,GADD45A,GBP2,GNAI2,GZMB,HMOX1,IL12B,IL1R2,IL33,LPIN1,MAP1LC3B,Meis1,MMP9,MYC,MYCN,NGFR,Nrgn,NUDT5,PCK1,PLAT,PNPLA2,PPARA,PPP1R1B,PPP1R3C,PRF1,PTGS2,RGCC,SELE,SERPINE1,Sik1,SOX18,SOX2,STAT1,SYT1,TFPI2,TIMP1,TNFAIP6,TRH,ZEB2 | 545 (19) |
| RNF138 | -7.00e-02 | enzyme | Activated | 2.65e+00 | 0.0e+00 | BCL2L1,GADD45B,IER3,IL1A,LRRC32,RGS16,SPECC1 | 218 (7) |
| carbamazepine | NA | chemical drug | Activated | 2.63e+00 | 3.0e-02 | ATF3,ATF4,MAP1LC3B,OSMR,PSAT1,SLC7A1,TNFRSF12A | NA |
| N-acetylsphingosine | NA | chemical reagent | Activated | 2.62e+00 | 0.0e+00 | BCL2L1,Ccl2,CDKN1A,CXCL2,FOS,PTGS2,SERPINE1,SPHK1 | 402 (18) |
| crocidolite asbestos | NA | chemical toxicant | Activated | 2.61e+00 | 0.0e+00 | Ccl2,CXCL2,FOS,FOSL1,FOSL2,GADD45A,GCLC,JUNB,LIF,MYC | 496 (17) |
| TREX1 | 4.30e-01 | enzyme | Activated | 2.60e+00 | 0.0e+00 | BANK1,CCL2,CD274,CDKN1A,CMPK2,CXCL10,GBP4,GBP5,IFI44,IFI44L,IFIT1,IKBKE,IL12B,IL33,IRF4,ISG15,MX1,Mx2,OAS2,PRKCH,PROCR,RSAD2,STAT1,TNFSF10,TRIM14,TXNIP,UBA7,USP18,ZBP1 | 256 (16) |
| gentamicin | NA | chemical drug | Activated | 2.60e+00 | 0.0e+00 | ABCC2,AK1,APCS,AQP1,ATF3,Bhlhe41,BMP6,BMP7,BTG2,CA4,CBS/LOC102724560,CCL2,Ccl2,CD69,CDO1,CHORDC1,CTSV,CXCL10,DIO1,FOS,GADD45A,GJB2,HMOX1,HNF4A,HSD11B2,IFRD1,JUNB,KHDRBS3,KYNU,LAG3,LCN2,LGALS3,LOC102549726,MAPKAPK3,MYC,Ppp1r15a,PSAT1,RBP4,RGCC,SEZ6L,SFPQ,SOCS2,TIMP1 | 444 (19) |
| MAP3K1 | NA | kinase | Activated | 2.60e+00 | 0.0e+00 | ATF3,DUSP1,FOS,HMOX1,MAOB,PLAUR,PTGS2,SERPINE1,THBS1,TIMP1 | 458 (16) |
| RPS6KA5 | NA | kinase | Activated | 2.60e+00 | 0.0e+00 | DUSP1,FOS,FOSL1,IL12B,JUNB,MYC,PTGS2 | 420 (15) |
| SB 216763 | NA | chemical drug | Activated | 2.59e+00 | 0.0e+00 | BHLHE40,CCL2,FASN,MYC,PCK1,PTGS2,RND3,SOX2,TNFSF10 | 513 (20) |
| thioacetamide | NA | chemical toxicant | Activated | 2.58e+00 | 0.0e+00 | ABCC2,ADAMTS1,AOC1,ARG2,BHLHE40,Ccl2,CD14,CLDN4,CPT1B,Ctla2a,EHD3,FGA,FOS,IER3,IFITM2,ITGA7,KDR,LCN2,LGALS3,LIN7A,LOX,LYVE1,MYC,ODC1,PDGFB,PDGFD,PLA1A,POR,PTGS2,RBM3,RCN1,RGCC,SCN1B,SLC13A3,SOX2,Sry,TIMP1,TMC5,TNFRSF12A,Tsc22d3,UPP1,WNT5A | 497 (12) |
| EIF4E | 3.00e-02 | translation regulator | Activated | 2.57e+00 | 0.0e+00 | Acan,ADAMTS15,BCL2L1,C3AR1,Ccl2,CD274,CDKN1A,CX3CR1,EREG,FOSL1,HMOX1,IL1A,IL33,LAG3,LAT2,MMP9,MYC,NFKBIA,NRP1,ODC1,PGF,PLAUR,PTPRC,SLC11A1,SLC2A5,SPHK1,TGFA,TMEM119,TP53BP2,UBA7,UPP1 | 497 (21) |
| ERK1/2 | NA | group | Activated | 2.57e+00 | 0.0e+00 | AOC1,BCL2A1,BCL2L1,BMP2,CCL2,Ccl2,CCL4,CDKN1A,COL2A1,CTSV,CXCL10,CXCL3,CXCL6,CXCR4,CYP46A1,DUSP1,ECE1,EDN1,F3,FKBP5,FOS,FOSL1,GNRH1,GRK5,HK2,IFIT1,IL12B,IL1A,JUNB,KRT17,MAP4K1,MMP9,MYC,MYCN,MYOCD,PLAUR,PTGS2,SERPINE1,SOCS3,SOX2,TIMP1,TRIM63 | 437 (16) |
| cyclopamine | NA | chemical reagent | Activated | 2.56e+00 | 0.0e+00 | CD14,CDKN1A,GLI1,HSD11B2,MYCN,PTGS2,SERPINE1,SMO,SMPD3,SOX2 | 420 (17) |
| AR | -7.80e-01 | ligand-dependent nuclear receptor | Activated | 2.56e+00 | 0.0e+00 | Akap17b,ANKRD1,AQP3,AR,ARG2,ARMCX2,AZGP1,BCL2L1,CA4,CCL17,Ccl2,CCL24,CCNA1,CDKN1A,CDO1,CERS6,CLDN11,CXXC5,DAB2IP,DDIT4,DHH,DISP2,EDN1,EDNRA,EHD3,ERBB3,ERN1,F9,FKBP5,GADD45G,GNRH1,IGSF8,IL1A,LAMA5,LIF,MAOA,MCCC2,MMP9,MYC,NGFR,NPR3,NR5A2,Nrgn,NUPR1,ODC1,P4HA1,PBK,PCK1,Pcp4l1,PEMT,PER1,PLAT,Pln,RGN,SCN4A,SERPINE1,Sik1,SLC43A1,STAT1,SYCE1,TBC1D8,THBS1,TIMP3,TNFRSF12A,TNFSF10,Tsx,ZBP1,ZBTB16 | 463 (18) |
| birabresib | NA | chemical drug | Activated | 2.55e+00 | 6.0e-02 | ADAMTS1,IFI44,IFI44L,KANK4,MYC,MYCN,USP18 | NA |
| RETN | -1.40e-01 | other | Activated | 2.54e+00 | 0.0e+00 | CCL2,Ccl2,CX3CR1,CXCL3,EDN1,FABP3,FASN,FOS,HMOX1,MYC,PLAT,PTGS2,SELE,SELP,SERPINE1,SOCS3 | 382 (19) |
| SRC | -9.00e-02 | kinase | Activated | 2.54e+00 | 0.0e+00 | ABCB11,BCL2L1,CCL2,CDKN1A,CDON,CTSV,CXCL10,DUSP1,F3,FOS,FOSL1,HAS1,HCN4,MMP9,MYC,PLAT,PLAUR,PTGS2,TFPI2 | 396 (18) |
| IGF1 | -1.40e-01 | growth factor | Activated | 2.53e+00 | 0.0e+00 | Acan,ADORA2B,ATP2B3,BCL2A1,BCL2L1,BHLHE40,BMP2,BTG2,CAP2,Ccl2,CCL4,CDH6,CDKN1A,CEBPD,COL2A1,CREB1,Csprs (includes others),CXCL6,DDIT4,DHH,DUSP1,EDN1,ERRFI1,F3,FASN,FJX1,FOS,GADD45A,GADD45G,GHRHR,GNRH1,HDC,HMOX1,HSD11B2,IER3,IL1A,IL4R,IRS1,JUNB,KCNF1,KCNJ5,LARP6,LCN2,LGALS12,MMP16,MUC5B,MYC,MYCN,NFKBIA,NUPR1,ODC1,OSMR,PBK,PLAUR,PPP1R1B,PTGS2,PTPRC,Rcan1,RTKN2,RYR2,SELE,SERPINE1,SFN,SOCS3,SOX2,TGFA,THBS1,TNFRSF12A,TRPV1,TXNIP,ZFP36 | 655 (22) |
| NEDD9 | -9.40e-01 | other | Activated | 2.53e+00 | 0.0e+00 | BHLHE40,BMP2,Ccdc30,DDIT4,DNALI1,ERRFI1,FOS,KCNRG,KIF9,LIN7A,MKNK2,MMP9,NRN1,PCK1,Podxl,SERPINE1,TXNIP | 456 (15) |
| ethionine | NA | chemical toxicant | Activated | 2.53e+00 | 0.0e+00 | CD14,FGA,IER3,LCN2,LGALS3,MYC,PLA1A,TIMP1,TNFRSF12A,UPP1 | NA |
| NORAD | NA | other | Activated | 2.53e+00 | 0.0e+00 | BHLHE40,FSTL3,GADD45B,JUNB,LARP6,SEC14L2,SPOCK1,SSBP3,THBS1,TNFRSF12A | 282 (10) |
| ASPSCR1-TFE3 | NA | fusion gene/product | Activated | 2.53e+00 | 4.0e-02 | BHLHE40,G0S2,GABARAPL1,HMOX1,KCNJ4,MAFF,NPC2,P4HA2,TCN2,UPP1 | NA |
| Ttc39aos1 | NA | other | Activated | 2.53e+00 | 0.0e+00 | BCL2A1,Ccl2,CCL4,CXCL10,GBP2,IFI44,IFIT1,Igtp,ISG15,Mx2,OAS2,RNF213,RSAD2,SERPINE1,TNFSF10,USP18 | 328 (12) |
| cytokine | NA | group | Activated | 2.53e+00 | 0.0e+00 | ADAMTS4,ADORA2A,BCL2L1,CCL2,CCR6,CD27,CD40LG,CD69,CRP,CXCL3,DUSP1,EDN1,F3,FOS,HMOX1,IL24,LIF,MMP9,MYC,PLAT,PLAUR,PON1,PTGS2,SELE,SELP,SERPINE1,SOCS2,SOCS3,TIMP1,TNFAIP6,UPP1 | 378 (15) |
| hyaluronic acid | NA | chemical - endogenous mammalian | Activated | 2.53e+00 | 0.0e+00 | ABCB1,BCL2L1,Ccl2,CCL4,CD83,COL2A1,CXCL10,CXCL2,CXCL3,CXCR4,FOS,IL12B,LYVE1,MMP9,NFKBIA,PTGS2,PTPRC,SERPINE1,SOCS3,SPHK1,TIMP1 | 373 (16) |
| methapyrilene | NA | chemical drug | Activated | 2.52e+00 | 0.0e+00 | ALB,ATF3,ATF4,BTG2,CBS/LOC102724560,CPT1A,CRP,CTSV,CXCL3,FGA,GADD45A,GCLC,GJB1,GRB14,HMOX1,IFRD1,ITIH4,KYNU,MAOB,Mt1,Mx2,MYC,ODC1,Ppp1r15a,PRKCB,SLC10A1,TXNRD1 | NA |
| clopidogrel | NA | chemical drug | Activated | 2.52e+00 | 0.0e+00 | ATF3,CCL2,Ccl2,CRP,F3,IFIT1,IFRD1,KLF15,LAMA5,LURAP1L,MYC,NUPR1,PSAT1,PTX3,RGS16,SESN2 | 290 (7) |
| methyl methanesulfonate | NA | chemical toxicant | Activated | 2.50e+00 | 0.0e+00 | ATF3,ATF4,BTG2,CDKN1A,CRELD2,GADD45A,GADD45B,GADD45G,LCN2,LIF,NFYA,NUPR1,Ppp1r15a | 449 (18) |
| STAT4 | NA | transcription regulator | Activated | 2.49e+00 | 0.0e+00 | ACAP1,ATF4,BANP,BCL2L1,CCL2,CD40LG,CXCL10,CXCL2,CXCL3,ERRFI1,GADD45G,GRTP1,IER3,IRF4,ISG15,ITGA7,LPIN1,MAP3K8,Mt1,MYC,P4HA2,PER1,RASL12,RASSF1,RGCC,RGS16,SAT1,SELE,SELENBP1,SERPINB1,SERPINE1,SOCS3,STAT1,TBX21,TGFA,TIMP1 | 467 (14) |
| Ige | NA | complex | Activated | 2.49e+00 | 0.0e+00 | AQP3,ASB2,BAIAP2,BCL2A1,BCL2L1,CCL17,CCL2,Ccl2,CCL24,CCL4,CDKN1A,CMPK2,CXCL2,CXCL3,EDN1,ERRFI1,GADD45B,HDC,HMOX1,IER3,IKBKE,IL12B,IL1A,IL33,IRF4,JUNB,LAMA5,LIF,LTA,MAP3K8,MAPKAPK3,MMD,MYC,NFKBIA,NGFR,NRP1,PDGFB,PIK3IP1,PTGS2,PTX3,RAMP3,RASGRP1,RFX2,RGS16,RSAD2,SEMA7A,SERPINB1,SLC11A1,SOCS3,SPHK1,TNFRSF12A,TNFSF10,XCL1 | 514 (16) |
| AKT1 | 2.80e-01 | kinase | Activated | 2.49e+00 | 0.0e+00 | ABCB1,Acan,ACTC1,ANKRD1,AR,AURKB,BCL2A1,BCL2L1,BMP2,CCL2,CCL4,CD69,CDKN1A,CEBPD,CIDEA,CTSV,CXCL10,CXCL2,CXCL6,CXCR4,FASN,FOS,GCLC,HMOX1,HUNK,IL12B,IRS1,KDR,KLF15,LCN2,MMP9,MYC,MYOCD,NEXN,PCK1,PEX11A,PLG,PPARA,PPP1R1B,PTGS2,RAMP3,SERPINE1,SHOX2,SOX2,TGFBR3,THBS1,TIMP1,TNFSF10,TP73,TRIM63 | 401 (14) |
| D-fructose | NA | chemical - endogenous mammalian | Activated | 2.49e+00 | 0.0e+00 | Ccl2,CXCL10,CXCL2,FASN,IL1A,SLC26A3,SLC2A5,SLC5A1,THBS1,TIMP1,TIMP3 | 552 (20) |
| bleomycin | NA | biologic drug | Activated | 2.49e+00 | 0.0e+00 | ARRDC3,ATF3,BCL2L1,BHLHE40,CCL17,CCL2,Ccl2,CDKN1A,CXCL10,CXCL2,CXCL3,CXCR4,EPHA2,FOSL1,GAB2,GADD45A,GFI1,IL1A,IL4R,KLF15,LGALS3,LOX,MAFF,MAP1LC3B,MAP3K6,MMP8,MMP9,MYC,MYCT1,PLA1A,PLAT,PTX3,RGCC,SDC4,SEMA7A,SERPINE1,Sik1,SOCS2,SOCS3,SPHK1,STK17B,THBS1,TIMP1,TIMP3,TINAGL1,WNT5A | 537 (17) |
| EPHA2 | 7.30e-01 | kinase | Activated | 2.48e+00 | 0.0e+00 | ARRDC3,ATF3,CD274,CXCL2,DUSP1,EDN1,FOS,IER3,IL33,JUNB,MMP9,SELE,SOX2,ZFP36 | 440 (22) |
| promegestone | NA | chemical drug | Activated | 2.48e+00 | 0.0e+00 | BCL2L1,BTG2,CDKN1A,ERBB3,F3,FKBP5,GAL,HSD11B2,HSD17B2,IER3,MYC,NFKBIA,PDK4,PPP1R1B,STAT1,TXNIP,ZBTB16 | 514 (21) |
| 4-methylnitrosoamino-1-(3-pyridinyl)-1-butanone | NA | chemical toxicant | Activated | 2.47e+00 | 0.0e+00 | BCL2L1,CDKN1A,CHRNA7,EZH2,FASN,FOS,IKBKE,IL6R,JUNB,LOX,PTGS2,SOCS3 | 483 (19) |
| SMAD4 | 1.10e-01 | transcription regulator | Activated | 2.46e+00 | 0.0e+00 | Acan,AGR2,APOB,BMP2,BMP7,CCL2,Ccl2,CCL24,CD79A,CDKN1A,COL2A1,CXCL2,CXCL3,CXCL6,DNAH2,EDN1,EREG,FOS,FOSL1,FSTL3,GADD45A,GADD45B,GLI1,HMCN1,HMOX1,HNF4A,IER3,IL12B,INHBA,ITGB7,KLF15,LPAR1,MYC,MYCN,NFKBIA,PDGFB,POR,PTGS2,PTPRC,PTX3,RASSF1,RGCC,SELE,SERPINE1,SFTPB,SMO,SOX2,SPHK1,TBX21,TBX6,THBS1,TIMP1,TIMP3,TNFAIP6,XCL1,ZFP36 | 541 (21) |
| STAT6 | -1.20e-01 | transcription regulator | Activated | 2.46e+00 | 0.0e+00 | ABLIM1,Acot1,APOLD1,ARID5A,BCL2L1,CAMK1D,CCL17,CCL2,Ccl2,CCL24,CD69,CD79B,CDKN1A,CMPK2,CPT1A,CR2,CTSW,CXCL10,CXCL2,CXCL3,Cyp4a14,EPHA2,FASN,FCER2,FKBP5,GADD45B,GADD45G,GBP2,GBP5,GBP7,GCSAM,GFI1,H2-T22,HIPK2,IFI44,IFI44L,Igtp,IL12B,IL1A,IL24,IL33,IL4R,IRF4,Irgm1,ISG15,ITGB7,LIF,LPIN2,LTA,LTB,MAOA,MMP9,NEDD9,NFIL3,NFKBIA,PCYOX1L,PDK4,PLCD1,PNPLA2,POU2AF1,POU2F2,PPARA,PTGS2,RNF213,RYR2,SELE,SELENBP1,SELP,SERPINE1,SOCS2,SPHK1,TBX21,TIMP1,TIMP3,TNFRSF8,ZBP1,ZFP36 | 404 (15) |
| hydrogen peroxide | NA | chemical - endogenous mammalian | Activated | 2.46e+00 | 0.0e+00 | ABCB1,ANKRD1,AR,ATF3,BANP,BCL2A1,BCL2L1,BTG2,CCL2,Ccl2,CCL4,CDKN1A,CSF3R,CXCL3,CXCL6,CXCR4,DDIT4,DUSP1,DUSP8,EDN1,ENC1,EPHA2,EZH2,F2RL1,FASN,FOS,FOSL1,GADD45A,GADD45B,GCLC,GFPT2,GLI1,GZMB,HDC,HIPK2,HMOX1,IL1A,IRS1,KDR,LCN2,MCAM,MMP8,MMP9,MYC,NFIL3,ODC1,OSGIN1,PDGFB,PGF,PKIA,PLAUR,Pmaip1,PPARGC1B,PTGS2,PTX3,RCN1,ROR2,SERPINE1,SERPINH1,SESN1,SFTPB,TGFBR3,TP73,TRPC3,TXNIP,WNT5A | 513 (17) |
| 5-hydroxytryptamine | NA | chemical - endogenous mammalian | Activated | 2.46e+00 | 1.0e-02 | CCL2,F3,FOS,GNAI2,GTF3A,IL1A,ITGA2B,MYC,PKN1,PTGS2,SEMA6B,SERPINE1,THBS1,TRPV1 | 466 (20) |
| HIRA | 1.80e-01 | transcription regulator | Activated | 2.45e+00 | 0.0e+00 | Ccl2,CXCL2,CXCL6,EREG,PGF,SPHK1 | NA |
| DUSP11 | -1.00e-01 | phosphatase | Activated | 2.45e+00 | 0.0e+00 | CMPK2,IFI44,ISG15,Oasl2,RSAD2,USP18 | 315 (12) |
| Z36 | NA | chemical reagent | Activated | 2.45e+00 | 0.0e+00 | ATF4,CDKN1A,ERN1,HMOX1,MAP1LC3B,NUPR1 | 320 (10) |
| BMP6 | -6.40e-01 | growth factor | Activated | 2.45e+00 | 0.0e+00 | ADAMTS1,ADAMTS5,ADGRL2,CDKN1A,ERRFI1,FOSL1,HMOX1,IL1A,INHBA,Meis1,MYCN,PTGS2,SERPINE1,SLC39A10,SMARCA1,TIMP1,TNFRSF12A,TXNRD1 | 409 (19) |
| GNA13 | 3.10e-01 | enzyme | Activated | 2.44e+00 | 0.0e+00 | Ccl2,CXCL2,CXCL3,CXCL6,FOS,PTGS2 | 381 (16) |
| sulforafan | NA | chemical drug | Activated | 2.43e+00 | 0.0e+00 | ABCB1,ABCC2,ADAMTS1,BCL2L1,CCL2,CDKN1A,ERBB3,FOS,FTL,GCLC,Gsta1,HIPK2,HMOX1,IL12B,IL6R,KDR,KRT17,MMP9,Mt1,NFKBIA,NR0B2,PPARGC1B,PTGS2,PTPRC,RUNX1T1,SELE,SLC6A2,SOCS3,TBC1D8,TIMP3,TMEM178A,TXNRD1,USP18 | 422 (22) |
| TNFRSF18 | -7.60e-01 | transmembrane receptor | Activated | 2.43e+00 | 0.0e+00 | BCL2L1,CCL2,CDKN1A,CXCL3,MMP9,PTGS2 | 395 (15) |
| TNFRSF10A | 3.80e-01 | transmembrane receptor | Activated | 2.43e+00 | 0.0e+00 | CD14,CD28,CD3G,IL12B,LCK,TNFSF10 | 227 (12) |
| GDNF | 7.00e-02 | growth factor | Activated | 2.43e+00 | 9.0e-02 | AR,CLDN5,HSD11B2,NRN1,PPP1R1B,SCN10A,SPHK1 | NA |
| PTH | NA | other | Activated | 2.42e+00 | 0.0e+00 | Acan,ADAMTS1,BHLHE40,BMP2,CCL2,Ccl2,CDKN1A,Clec2d (includes others),COL2A1,CREM,CXCL2,CXCR4,DUSP1,FOS,FOSL2,GALNT3,ID4,IL33,IL6R,MGP,NFIL3,ODC1,PDK4,Plekha6,PPP1R1B,PTGS2,RAMP3,RBM14,SDC4,Slpi/Slpil2,SOCS3,TFPI2,TMEM119,WNT7A | 492 (23) |
| Ck2 | NA | complex | Activated | 2.41e+00 | 0.0e+00 | ATF4,BCL2L1,FOS,MYC,NGFR,ZFP36 | 521 (23) |
| SIRT1 inhibitor III | NA | chemical drug | Activated | 2.40e+00 | 8.0e-02 | CDKN1A,FASN,IL12B,Pmaip1,SESN2,TRH | NA |
| cocaine | NA | chemical drug | Activated | 2.40e+00 | 0.0e+00 | Acot1,ADORA2A,BHLHE40,CCL2,Ccl2,CPT1A,CREB1,CXCL2,DUSP1,DYNLL1,FOS,FOSL1,GADD45A,GADD45B,GNAI2,IFIT1,INHBA,JUNB,MAP2K6,MKNK2,MX1,PDGFB,PER1,PPP1R1B,Sik1,SLC6A2,SSTR4,STAT1,THBS1,TRH | 486 (22) |
| dibutyl phthalate | NA | chemical toxicant | Activated | 2.40e+00 | 0.0e+00 | AR,FOS,JUNB,MYC,POR,SERPINE1 | 479 (19) |
| Pka | NA | complex | Activated | 2.39e+00 | 1.0e-02 | CD14,CDKN1A,CREM,CXCL10,DUSP1,EDN1,FOS,HMOX1,HNF4A,JUNB,PCK1,POU2AF1,PPP1R1B,PTGS2,SFTPB | NA |
| 5-fluorouracil | NA | chemical drug | Activated | 2.38e+00 | 1.0e-02 | ATF3,ATF4,BAIAP2,BCL2L1,BTG2,CCNA1,CDKN1A,DLL1,EPHA2,ERN1,GADD45A,HMOX1,HSPA4L,IL1A,LCN2,LIF,MMP9,MYC,OGT,OSGIN1,PROCR,PTGS2,SAT1,SERPINB1,SESN1,SFN,SPHK1,TGFA,THBS1,TNFRSF12A,TXNIP,UPP1 | 532 (19) |
| MAP3K7 | 1.60e-01 | kinase | Activated | 2.37e+00 | 0.0e+00 | Ccl2,CD14,CXCL10,CXCL2,CXCL6,GBP2,HMOX1,IFI44,IFIT1,IL12B,OAS2,PDGFB,PTGS2,SELE,SERPINE1,TNFSF10,WNT5A | 443 (17) |
| 1-palmitoyl-2-oleoylphosphatidylserine | NA | chemical - endogenous mammalian | Activated | 2.36e+00 | 0.0e+00 | BMP2,CCL4,CXCL10,CXCL2,CXCL3,LIF,TGFA,TNFRSF12A,Tnfsf9 | NA |
| DRD2 | -4.00e-02 | G-protein coupled receptor | Activated | 2.36e+00 | 0.0e+00 | CCL2,CXCL2,CXCL3,FOS,FOSL2,KCNJ4,LTB,NAT8L,NFKBIA,PNPLA2,SERPINE1,THBS1,Tnfsf9 | 409 (17) |
| Salmonella enterica serotype abortus equi lipopolysaccharide | NA | chemical toxicant | Activated | 2.36e+00 | 0.0e+00 | ADORA2B,ATP1B1,Ccl2,CCL4,CD274,CXCL2,CXCL3,EDN1,EGR3,EREG,EZH2,F3,FJX1,FOSL1,G0S2,GADD45A,GADD45B,GEM,GJB2,HAS1,IL12B,IL1A,INHBA,ISG15,MAFF,MAP3K8,NEDD4L,NOCT,OSGIN1,PLA1A,PTGS2,PTX3,SGPP2,SOCS3,TFPI2,THBS1,WNT5A | 516 (17) |
| NFAT5 | -1.90e-01 | transcription regulator | Activated | 2.35e+00 | 0.0e+00 | Acan,AQP1,AQP3,AR,BCL2A1,C1QTNF1,CCL2,Ccl2,CCR3,CIITA,CXCL10,CXCL3,DDIT4,EDN1,EREG,F3,FABP3,IL6R,Irgm1,LCN2,LIF,Mx2,NFKBIA,PLAT,PRSS35,RSAD2,SEMA4C,SLC6A12,SLC6A6,STAT1,TNFRSF21,TNFSF10 | 451 (21) |
| tert-butyl-hydroquinone | NA | chemical reagent | Activated | 2.35e+00 | 0.0e+00 | ATF3,FOS,FOSL1,FOSL2,FOXC1,FTL,GADD45A,GCLC,GNAI2,Gsta1,HMOX1,JUNB,OSGIN1,SERPINE1,SESN2,SNX19,TXNRD1,WNT5A,ZNF184 | 469 (20) |
| STAT1/3/5 dimer | NA | complex | Activated | 2.35e+00 | 0.0e+00 | BCL2L1,CEBPD,CRP,FOS,JUNB,SOCS2,SOCS3,TIMP1,TIMP3 | NA |
| IL6R | 8.30e-01 | transmembrane receptor | Activated | 2.34e+00 | 0.0e+00 | BCL2L1,CCL2,CDKN1A,COL2A1,CXCL10,CXCL2,CXCL3,CXCL6,GAL,IL6R,LCN2,MMP9,PTGS2,SOCS3,TIMP1,TRH | 385 (15) |
| TP53 | 5.00e-02 | transcription regulator | Activated | 2.34e+00 | 0.0e+00 | ABCB1,ABCC2,ACER2,ADGRE5,ADORA2B,ADRA1A,AK1,ALB,ANKRD1,ANXA3,ANXA8/ANXA8L1,AQP3,AR,ARVCF,ATF3,ATF4,ATP1A1,AURKB,BCL2A1,BCL2L1,BHLHE40,BMX,BTG2,C9,CALCRL,CCL2,Ccl2,CCL4,CCR9,CDKN1A,CEBPD,CERS6,CKMT1A/CKMT1B,COL2A1,CPT1A,CPT1B,CSF3R,CTSH,CTSW,CXCL10,CXCL2,CXCL3,CYP26B1,CYSLTR1,DDIT4,DLGAP1,DNAJB5,DUSP1,DYNLL1,DYSF,EDN1,EDNRA,EGR3,ENO3,EPHA2,EREG,ESRRG,EZH2,F3,FABP3,FASN,FAT2,FGFBP1,FKBP5,FOS,FOSL1,FSTL3,FUBP1,G0S2,GADD45A,GADD45B,GADD45G,GAS7,GLI1,GLUL,GNAI2,HDC,HK2,HMOX1,HSPA4L,IER3,IFI44,IFI44L,IFIT1,IL1A,IL21R,IL33,IL4R,INHBA,IRAK2,IRS1,ISG15,ITGA2B,ITGB7,JUNB,KCNG1,KCNJ4,KDR,LAMA5,LCN2,LGALS3,LIF,LIMK1,LOX,LPIN1,LRRC17,MAP1LC3B,MAP2K6,MAP3K8,MAP4K1,MCAM,MEOX1,MMP9,MX1,MYC,MYLK3,MYOCD,NEXN,NFKBIA,NR0B2,NRP1,NUDT5,NUPR1,ODC1,OSGIN1,OVOL2,OXA1L,P2RY14,P4HA1,PBK,PCK1,PDGFB,PDHA1,PFKFB3,PHKG1,PHLDB3,PLAUR,Pln,Pmaip1,PPARA,PPARGC1B,PPP1R13B,PRKCB,PRKCG,PTGER1,PTGS2,PTPRN,PTPRO,RAMP3,RBM3,RGS16,RND3,RSAD2,RYR2,SAT1,SELE,SELP,SERPINC1,SERPINE1,SERPINH1,SESN1,SESN2,SFN,SFPQ,SLC6A6,SLC7A5,SOCS2,SOX2,SPHK1,SPN,STAT1,TCEA3,TCN2,TET1,TFPI2,TGFA,THBS1,TIMP1,TIMP3,TINAGL1,TNFRSF18,TNFSF10,TP53BP2,TP53I13,TP73,TRPV1,UBC,UPP1,WNT7A,XPO1,ZC3H12A,ZEB2,ZFP36 | 537 (18) |
| CHD1 | 2.80e-01 | enzyme | Activated | 2.33e+00 | 0.0e+00 | BCL2A1,BMP2,CXCL2,CXCL3,CXCL6,IER3,IL1A,LIF,PTGS2 | NA |
| hexachlorobenzene | NA | chemical toxicant | Activated | 2.33e+00 | 0.0e+00 | CD14,Ctla2a,FGA,IER3,LCN2,LGALS3,MMP9,MYC,RCN1,TIMP1,TNFRSF12A,UPP1 | 379 (15) |
| SOCS1 | 1.80e-01 | other | Activated | 2.33e+00 | 0.0e+00 | BCL2A1,BCL2L1,CCL2,Ccl2,CCR6,CD274,CD69,CDKN1A,CIITA,CXCL10,CXCL2,DUSP1,FKBP5,FOS,GBP5,H2-T24,IFI44,IFIT1,IL2RB,IL4R,IRS1,ISG15,MX1,Mx2,OAS2,Oasl2,PTGS2,RSAD2,SELE,SOCS3,STAT1,USP18 | 339 (16) |
| IKBKB | 3.50e-01 | kinase | Activated | 2.32e+00 | 0.0e+00 | ANKRD1,AR,ATF3,AURKB,BCL2L1,BMP2,CBLB,CCL17,CCL19,CCL2,Ccl2,CCL4,CCR3,CDKN1A,CEBPD,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,CYP7B1,EDN1,EREG,EZH2,F3,FASN,FOS,GADD45A,GBP2,GLI1,GNRH1,GRK5,HAS1,HK2,HMOX1,IL12B,IL1A,ISG15,JUNB,LCN2,LTB,MGP,MMP9,Mt1,MX1,MYC,NFKBIA,NOCT,POU2AF1,PTGS2,PTX3,RGS16,SELE,SOCS2,SOCS3,TIMP3,TNFSF8,TRIM63 | 421 (13) |
| NfkB-RelA | NA | complex | Activated | 2.32e+00 | 0.0e+00 | BCL2L1,CCL2,CXCL10,CXCL3,MYC,NFKBIA,PTGS2,SELE,SOCS3 | NA |
| IL1A | 1.28e+00 | cytokine | Activated | 2.31e+00 | 0.0e+00 | ABCC2,ADAMTS1,ADAMTS4,ADAMTS5,ADORA2A,ADORA2B,ATF3,BCL2L1,CCL2,Ccl2,CCL4,CCR6,CD274,CD83,CDKN1A,CXCL10,CXCL2,CXCL3,CXCL6,F2RL1,FOS,FOSL1,HDC,HMOX1,HSD11B2,IAPP,IER3,IL12B,IL1A,IL1R2,INHBA,JUNB,LCN2,LIF,LOX,MCAM,MMP9,MYC,NFKBIA,PDGFB,PTGS2,PTX3,S100A8,SELE,SERPINE1,TIMP1,TOX3,TRH,WNT5A,ZC3H12A | 501 (16) |
| phorbol 12,13-dibutyrate | NA | chemical - endogenous non-mammalian | Activated | 2.31e+00 | 0.0e+00 | BCL2L1,Ccl2,CDKN1A,FOS,MAP3K8,PRKCB,PTGS2,SERPINE1 | 406 (18) |
| TP63 | -3.80e-01 | transcription regulator | Activated | 2.31e+00 | 0.0e+00 | ABCB1,ADAMTS1,ADAMTS9,AGR2,BCL2L1,BHLHE40,BMP3,BMP7,CA4,CDKN1A,CTSV,CXCR4,CYP26B1,DDIT4,DLL1,EDN1,EPHA2,ERBB3,F3,FASN,FGF11,FOS,FOSL1,FOSL2,FUBP1,GADD45A,GAL,GFI1,HAS3,HK2,IER3,IKBKE,IL1A,IL4R,INHBA,IRF4,ITGA7,JAK3,JUNB,KCNG1,KCNK1,KRT17,KRT7,KRT75,LCN2,LIF,MAFF,MLPH,MMP16,MMP9,MYC,NCS1,PKP1,Pmaip1,PPARA,PTGS2,RASGRF1,RASGRP1,S100A8,SERPINE1,SESN2,SFN,SOX2,ST8SIA6,STON2,THBS1,TIMP3,TINAGL1,TNFSF10,TNS4,TP73,WNT5A,WNT7A,ZEB2 | 463 (18) |
| zymosan | NA | chemical - endogenous non-mammalian | Activated | 2.29e+00 | 0.0e+00 | ARNT2,CCL17,Ccl2,CCL24,CCL4,CIITA,CPT1B,CXCL10,CXCL2,CXCL3,FTL,HMOX1,IKBKE,IL12B,IL1A,IL4R,IRF4,LIF,PPARA,PPARGC1B,PTGS2,SOCS3,SPN,THRB | 380 (16) |
| IL6 | NA | cytokine | Activated | 2.28e+00 | 0.0e+00 | ABCB11,ABCC2,ACER2,ADAMTS1,ADAMTS4,ADAMTS5,ADGRE1,ADGRE5,ADGRL2,ADORA2B,ALB,APCS,APOB,AR,ATF3,BCL2L1,BMP2,BMP6,BTG2,CCL2,Ccl2,CCL24,CCL4,CCNA1,CCR3,CCR6,CD14,CD163,CD274,CD79A,CD83,CDKN1A,CEBPD,CIB2,CIITA,CLEC10A,COL2A1,CPB2,CRP,CSF3R,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DIO1,DUSP1,EPHA4,EREG,ERN1,ERRFI1,EZH2,F3,FCER2,FGA,FGL1,FOS,FOSL1,GADD45A,GADD45B,GADD45G,GAL,GBP2,GLI1,GZMB,HMOX1,HPX,IFIT1,IKBKE,IL12B,IL4R,IL6R,IRF4,IRS1,JUNB,KDR,KLRD1,LAG3,LCN2,LIF,LY86,MERTK,MMD,MMP8,MMP9,Mt1,Mt1m/Mt2A,MYC,MYCN,NFKBIA,PDGFB,PGF,PLAT,PLG,PON1,PRF1,PTGS2,PTPRC,RASSF1,RNASE6,SELP,SERPINE1,SFTPB,SLC10A1,SLC7A7,Slco1a1,SMIM3,SMO,SOCS2,SOCS3,SOX2,STAT1,TBX21,TFR2,TGFA,THBS1,TIMP1,TLR10,TLR5,TNFRSF12A,TNFSF10,TNS4,TRH,WNT5A,XCL1 | 529 (17) |
| P38 MAPK | NA | group | Activated | 2.28e+00 | 0.0e+00 | ARG2,ATF3,BCL2A1,BCL2L1,BMP2,CCL17,CCL2,Ccl2,CCL24,CD69,CD83,CDKN1A,CEBPD,CLDN5,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DIO2,DUSP1,EDN1,F3,FCER2,FOS,GCLC,HMOX1,IER3,IL12B,IL1A,INHBA,IRX1,JUNB,KLF15,MMP9,MUC5B,MYBPH,MYC,Nes,NGFR,PCK1,PLAUR,PTGS2,RND3,SELE,SERPINE1,SLC6A12,SLC6A2,SOCS3,STAT1,TBX21,TGFA,THBS1,TIMP1,TIMP3,TNFSF10,TRIB1,TRPC3,WNT5A,ZFP36 | 478 (15) |
| Irgm1 | -6.30e-01 | other | Activated | 2.28e+00 | 0.0e+00 | AURKB,Ccl2,CXCL10,GBP2,GBP4,GBP5,GBP7,IFI44,ISG15,Mx2,NUPR1,OAS2,Oasl2,RSAD2,SELP,STAT1,TRIM14,USP18,ZBP1 | 356 (19) |
| STAG2 | -5.00e-02 | other | Activated | 2.27e+00 | 0.0e+00 | CD274,CD69,CMPK2,CXCL10,GBP2,IFI44,IFI44L,ISG15,RSAD2,SELL,USP18 | 218 (7) |
| capsaicin | NA | chemical drug | Activated | 2.27e+00 | 1.0e-02 | ATF4,BCL2L1,CXCL3,FOS,HMOX1,MMP9,PPARA,PTGS2,TRPV1 | 482 (18) |
| IL1B | -1.20e-01 | cytokine | Activated | 2.27e+00 | 0.0e+00 | ABCB11,ABCC2,Acan,ADAMTS1,ADAMTS4,ADAMTS5,ADORA2B,APCS,APOB,ATF3,ATF4,ATP1A1,BCL2A1,BCL2L1,BMP2,BMP7,BPIFB1,BTG2,CA12,CCL17,CCL2,Ccl2,CCL24,CCL28,CCL4,CCR6,CD14,CD274,CD40LG,CD69,CD83,CDKN1A,CEBPD,CERS6,CIITA,CLEC14A,CMPK2,COL2A1,CPB2,CREM,CRISPLD2,CRP,CSRNP1,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,CYP7B1,CYSLTR1,DACH1,DDIT4,DIO1,DLL1,DUSP1,EDN1,ERRFI1,F2RL1,F3,FCER2,FKBP5,FOS,FOSL1,G0S2,GADD45A,GADD45B,GBP2,GBP4,GBP5,GCLC,GEM,GJB1,GLI1,GNRH1,GZMB,HAS1,HK2,HLA-DOB,HMOX1,HNF4A,HSD17B2,IAPP,IER3,IFIT1,IFITM2,IFRD1,IKBKE,IKZF3,IL12B,IL1A,IL1R2,IL24,IL33,IL4R,IL6R,INHBA,IRAK2,IRF4,IRS1,ISG15,JUNB,KDR,LCN2,LIF,LOX,LTA,MAP2K6,MAP3K8,MMP8,MMP9,Mt1,MUC5B,MX1,MYC,MYLK3,NFIL3,NFKBIA,NOCT,NR0B2,NRP1,OAS2,ODC1,OSMR,PDGFB,PDGFD,PDHA1,PLAT,PPARA,PPARGC1B,PRF1,PTGS2,PTPRN,PTX3,RGCC,RGS16,RIMBP2,RSAD2,S100A8,SAT1,SDC4,SELE,SERPINE1,SERPINF2,SERPINH1,SESN1,SLC10A1,Slco1a1,SMPD3,SOCS2,SOCS3,SOX2,STAT1,TBX21,TFPI2,TGFBR3,TGM1,THBS1,TIMP1,TIMP3,TNFAIP6,TNFRSF19,TNFSF10,TREM3,TRH,TXNIP,USP18,WNT5A,XDH,ZC3H12A,ZFP36 | 515 (15) |
| palmitic acid | NA | chemical - endogenous mammalian | Activated | 2.26e+00 | 0.0e+00 | ADCYAP1R1,ATF3,ATF4,BCL2L1,CCL19,CCL2,Ccl2,CCL4,CD28,CDKN1A,CERS6,CIDEA,CPT1A,CPT1B,CXCL10,CXCL2,CXCL3,ERN1,F2RL1,FASN,FOS,GCLC,HK2,HMOX1,HNF4A,IAPP,IL12B,IL6R,INHBA,IRAK2,IRS1,LCN2,MAP1LC3B,Mt1,NFKBIA,NR0B2,PCK1,PDK4,PNPLA2,PNPLA3,PPARA,PPARGC1B,PPP2R2B,PROCR,PTGER3,PTGS2,SERPINE1,SHOX2,SOCS3,SPHK1,TNFSF10,TRIM63,TXNIP,VIPR2 | 572 (23) |
| cadmium | NA | chemical toxicant | Activated | 2.26e+00 | 0.0e+00 | ALB,ATP1A1,BCL2L1,CDKN1A,CUBN,CYP26B1,Gsta1,HMOX1,LGALS3,LOX,MGP,Mt1,MYC,PECR,PTGS2,SLC5A1,TIMP1 | 446 (19) |
| S1PR2 | -2.00e-01 | G-protein coupled receptor | Activated | 2.26e+00 | 0.0e+00 | Ccl2,F3,FOS,PDGFB,PTGS2,SELE,SPHK1,TIMP1 | 340 (16) |
| MAP2K1/2 | NA | group | Activated | 2.26e+00 | 0.0e+00 | ARG2,ATF3,Ccl2,CCL4,CXCL3,DUSP1,FOS,FOSL1,GCLC,HK2,HMOX1,MMP9,MYC,PPARA,Sik1 | 409 (18) |
| methotrexate | NA | chemical drug | Activated | 2.26e+00 | 0.0e+00 | ADORA2A,ALB,BTG2,CCL19,CCL2,CCL4,CD28,CDKN1A,CPT1A,CR2,CRP,CTSV,CXCL10,DUSP1,ENO3,FASN,FGA,GZMA,HMOX1,IL1A,IL4R,ITIH4,LPIN1,MAP2K6,Mt1,MYC,NGFR,PCK1,PECR,PPARA,PRKCB,PTGS2,SELL,SLC10A1,SOCS3,THBS1,TIMP3 | 541 (18) |
| L-glutamic acid | NA | chemical - endogenous mammalian | Activated | 2.25e+00 | 1.0e-02 | BCL2L1,Ccl2,CDKN1A,CLDN5,DLK1,FASN,FOS,GADD45B,JUNB,LIF,MMP9,NFIL3,PER1,PTGS2,TIMP1 | 442 (21) |
| bromobenzene | NA | chemical toxicant | Activated | 2.24e+00 | 0.0e+00 | ABCC2,CDKN1A,CDO1,CTSV,Cyp4a14,FMO3,FOS,GADD45A,GCLC,HMOX1,Mt1,Mt1m/Mt2A,MYC,POR,TIMP1 | NA |
| MAPK7 | -8.00e-02 | kinase | Activated | 2.24e+00 | 0.0e+00 | ADAMTS1,BCL2A1,CXCL10,CXCL2,CXCL3,DUSP1,EDN1,FASN,HMOX1,IL12B,IL1A,MYC,PLAT,PTGS2 | 398 (13) |
| D-sphingosine | NA | chemical - endogenous mammalian | Activated | 2.24e+00 | 0.0e+00 | Ccl2,CXCL2,IL4R,PTGS2,SERPINE1 | 362 (16) |
| oligomycin | NA | chemical - endogenous non-mammalian | Activated | 2.24e+00 | 0.0e+00 | CXCL10,DDIT4,KDR,PDGFB,SESN2 | 367 (14) |
| SFN | 1.45e+00 | other | Activated | 2.24e+00 | 2.0e-02 | BTG2,F3,FKBP5,PDK4,PPP1R1B | NA |
| ATF4 | 6.10e-01 | transcription regulator | Activated | 2.23e+00 | 0.0e+00 | ANGPTL3,ANKRD1,ATF3,ATF4,BCL11A,CCL2,CDKN1A,CPT1A,CXCL2,DDIT4,FASN,GADD45A,HNF4A,LGALS3,MAP1LC3B,NUPR1,OSMR,PCK1,Pmaip1,PSAT1,PTGS2,PTX3,SESN2,SLC38A2,SLC38A3,SLC43A1,SLC7A1,SLC7A5,SNTB1,TBC1D16,TNFRSF12A,WNT11,XDH | 452 (20) |
| CASP1 | 4.00e-02 | peptidase | Activated | 2.23e+00 | 0.0e+00 | Ccl2,CXCL2,CXCL6,FASN,IL1A,IL22RA2,KDR,LCN2,PPARA,PTGS2 | 397 (16) |
| bortezomib | NA | chemical drug | Activated | 2.23e+00 | 0.0e+00 | ABCB1,AGR2,AR,ATF3,ATF4,BCL2A1,BCL2L1,Ccl2,CCL4,CCR6,CDKN1A,CDR2,CEBPD,CXCL10,CXCL2,CXCR4,ERN1,FANCG,FCMR,GADD45A,GADD45B,GLI1,HSD11B2,IL12B,IL33,INHBA,IRF4,IRS1,LIF,MS4A1,MX1,MYC,MYOCD,ODC1,PTGS2,RSAD2,TNFSF10,TP53BP2 | 460 (23) |
| TGFB1 | -2.90e-01 | growth factor | Activated | 2.22e+00 | 0.0e+00 | ABCC2,ABL1,Acan,Acot1,ACTC1,ADAMTS10,ADAMTS4,ADGRG2,ADORA1,ADORA2B,ADRA1D,AGR2,AK1,ALB,ANKRD1,ANXA8/ANXA8L1,APOB,AQP1,ARL4A,ARNT2,ATF3,ATF4,ATP1B1,BCL2L1,BHLHE40,BMP2,BMP6,BMP7,BPIFB1,C3AR1,CCL2,Ccl2,CCL24,CCL4,CCNO,CCR10,CCR3,CCR6,CD101,CD14,CD163,CD274,CD28,CD69,CD83,CDC42EP4,CDHR1,CDKN1A,CEBPD,CEMIP,CHRNA7,CHST3,CIITA,CLDN4,COL2A1,CPT1B,CRP,CTSH,CX3CR1,CXCL10,CXCL2,CXCL3,CXCR4,DACH1,DACT1,DDIT4,DISP2,DKK2,DNAH2,DUSP1,DYNLL1,ECE1,EDN1,EDNRA,EGR3,ELK3,ENO3,EPHA2,EREG,EZH2,F2RL1,F3,FAM107A,FASN,FCER2,FERMT1,FGA,FGFBP1,FNDC5,FOS,FOSL1,FOSL2,FOXC1,FSTL3,FTL,FUBP1,GADD45A,GADD45B,GAL,GAS7,GBP2,GCLC,GEM,GFI1,GFPT2,GJB1,GJB2,GLI1,GLUL,GNAI2,GNRH1,GRHL1,GZMA,GZMB,H6PD,HAPLN3,HAS1,HAS3,HK2,HMOX1,HNF4A,HSF2BP,ID4,IER3,IFRD1,IKZF3,IL12B,IL1A,IL2RB,IL33,IL4R,IL6R,INHBA,IRAK2,IRS1,ITGA7,ITGB7,JUNB,KCNG1,KCNK1,KCNMB1,KDR,KLF15,KLRD1,KRT17,KRT7,KRT81,LCN2,LGALS3,LIF,LOX,LOXL1,LPAR1,LTA,LYVE1,MAOA,MGP,MKNK2,MMP9,MUC5B,MYC,MYCN,MYOCD,NEDD9,NFKBIA,NRP1,NUPR1,OSR2,OVOL2,P2RY14,P4HA1,PDE4A,PDGFB,PFKFB3,PHACTR1,PLA1A,PLAT,PLAUR,PLCL1,PPP1R13B,PPP1R14D,PPP1R1B,PPP1R3C,PRKCG,PROCR,PRSS22,PSAT1,PTGS2,PTPRC,PTPRN,PTX3,RAPGEF3,RASGRP1,RASSF1,RBM3,RGCC,RNF152,RSAD2,SDC4,SELE,SELENBP1,SELP,SEMA7A,SERPINB1,SERPINE1,SERPINF2,SERPINH1,SFTPB,SIX1,SLC13A3,SLC16A3,SLC16A9,SLC7A1,SLC7A5,SOCS3,SOX2,SPEG,SPHK1,SPOCK1,SRFBP1,STAT1,SYTL2,TBX21,TCN2,TGFA,TGFBR3,THBS1,TIMP1,TIMP3,TLL1,TNFAIP6,TNFRSF12A,TNFRSF14,TNFSF10,TP73,TTC22,TXNIP,TXNRD1,UCK2,WNT11,WNT5A,WNT7A,XCL1,XDH,ZEB2,ZFP36,ZFPM2 | 585 (20) |
| Histone h3 | NA | group | Activated | 2.22e+00 | 0.0e+00 | AADAT,ABCB1,ABCB11,ADCY5,ADRA1A,ATF3,CA4,CCL2,Ccl2,CCR3,CD69,CDKN1A,CIITA,CXCL10,DAB2IP,DIO1,ENO3,EZH2,FASN,FKBP5,FOS,GFI1,GLI1,HNF4A,IL1A,IL6R,IRF4,KDR,Meis1,MMP9,Mt1,MX1,MYC,Nes,NFKBIA,OSGIN1,PAX5,PCDHA4,PDGFB,PER1,PPP2R2B,PTGS2,RASSF1,RSAD2,RUNX1T1,S100A8,SELE,SELL,SFTPB,SLC6A2,SLC7A6,SOCS3,SPHK1,TBX21,TBX6,TET1,TNFSF10,TRIB1,UBC,UPP1,USP18 | 496 (20) |
| idarubicin | NA | chemical drug | Activated | 2.22e+00 | 0.0e+00 | CDKN1A,GADD45A,SESN1,SESN2,TP53BP2 | 337 (7) |
| caspase | NA | group | Activated | 2.22e+00 | 1.0e-02 | ACER2,CD14,CDKN1A,GLUL,IL1A,THBS1 | 480 (24) |
| deoxycorticosterone acetate/potassium chloride/sodium chloride | NA | chemical reagent | Activated | 2.22e+00 | 4.0e-02 | Ccl2,CXCL2,HNF4A,PTGS2,THRB | NA |
| inosine | NA | chemical - endogenous mammalian | Activated | 2.22e+00 | 1.5e-01 | FTL,Mt1,NPC2,SERPINB1,TIMP1 | NA |
| NFATC3 | -2.90e-01 | transcription regulator | Activated | 2.21e+00 | 0.0e+00 | ATF3,BMP2,CD40LG,CD69,CR2,DDIT4,EDN1,EGR3,F3,FOS,IL12B,MYOCD,PPP3R1,PTGS2,SFTPB | 327 (9) |
| sulindac sulfide | NA | chemical drug | Activated | 2.21e+00 | 1.0e-02 | ATF3,ATF4,BCL2L1,CDKN1A,DYNLL1,GADD45A,GADD45G,IFRD1,IL24,PTGS2 | 411 (16) |
| Cd2+ | NA | chemical toxicant | Activated | 2.21e+00 | 0.0e+00 | CXCL3,FOS,HMOX1,Mt1,MYC,PTGS2 | 420 (18) |
| vitamin K2 | NA | chemical drug | Activated | 2.21e+00 | 0.0e+00 | ABCB1,AR,CD14,MGP,SERPINB1 | 146 (4) |
| arachidonic acid | NA | chemical - endogenous mammalian | Activated | 2.21e+00 | 0.0e+00 | AQP3,BCL2A1,CD83,EDN1,F3,FASN,FOS,FOSL1,GLI1,HMOX1,IL12B,KDR,NFKBIA,PNPLA2,PRKCB,PTGS2,SELP,SOAT1 | 501 (20) |
| DCN | -1.70e-01 | other | Activated | 2.21e+00 | 1.0e-02 | CDKN1A,CXCL10,DUSP1,IRS1,MMP9,SERPINE1,THBS1,TIMP3 | 451 (22) |
| LEF1 | -3.90e-01 | transcription regulator | Activated | 2.20e+00 | 0.0e+00 | Acan,ACSBG1,AR,ARHGAP20,BLK,CCL4,CD101,CD19,CD274,CD79A,CD79B,CD83,CDKN1A,CEBPD,CSF3R,CX3CR1,CXCR4,DNASE1L3,G0S2,GEM,GZMA,H2-Eb2,Klrb1f,LAG3,LCK,LONRF1,MYC,NRN1,PDGFB,Pmaip1,PRF1,PRKCH,PTGS2,PTPRO,SMPD3,SPATC1,SPECC1,SRPK3,SYTL2,TBX21,TNFRSF13C,ZC3H12D | 365 (12) |
| PLIN5 | -9.00e-01 | other | Activated | 2.20e+00 | 0.0e+00 | ATF4,CPT1B,FASN,GCLC,HMOX1,PDK4,PNPLA2,PNPLA3,POR,PPARA,PPARGC1B,TXNRD1 | 440 (15) |
| XIAP | -2.70e-01 | enzyme | Activated | 2.20e+00 | 1.0e-02 | CDKN1A,MYC,PTGS2,SELE,SERPINE1 | NA |
| CREM | 7.00e-01 | transcription regulator | Activated | 2.20e+00 | 0.0e+00 | ACTC1,APOLD1,ATF3,BHLHE40,BTG2,CCNA1,CD8A,CREM,CSRNP1,CYP46A1,DIO2,DUSP1,ERRFI1,FOS,GADD45B,JUNB,MKNK2,NEXN,NFIL3,NPC2,PER1,Pln,RYR2,Sik1,THBS1 | 534 (22) |
| CYP1B1 | 4.40e-01 | enzyme | Activated | 2.20e+00 | 1.0e-02 | ARNT2,BMP7,C11orf87,CYSLTR1,FLRT3,GZMA,HMOX1,MCAM,Mt1,MYC,RGS16,Slco1a1,SOCS2,TNFSF10 | 298 (7) |
| cyclophosphamide | NA | chemical drug | Activated | 2.19e+00 | 0.0e+00 | ABCB11,ATF3,CD69,Ctla2a,CXCL2,CXCL3,CXCL6,FGA,FOS,IER3,IL12B,IL1R2,LGALS3,MYC,NGFR,ODC1,PLA1A,PTGS2,RBM3,THBS1,TIMP1,TNFRSF12A,UPP1 | 500 (21) |
| phenacetin | NA | chemical drug | Activated | 2.19e+00 | 0.0e+00 | ABCC2,CLDN4,FGA,IER3,LCN2,LGALS3,MYC,PLA1A,TIMP1,TNFRSF12A,UPP1 | NA |
| cyclopiazonic acid | NA | chemical - endogenous non-mammalian | Activated | 2.19e+00 | 0.0e+00 | BCL2A1,Ccl2,CXCL2,FOS,TRPC3 | 419 (16) |
| deferoxamine | NA | chemical drug | Activated | 2.19e+00 | 0.0e+00 | BHLHE40,CCL4,CD14,CDKN1A,DUSP1,ERRFI1,ESRRG,F3,FASN,FOS,GADD45A,GADD45B,GAS7,GEM,HK2,HMOX1,ITGB7,LCN2,MAP1LC3B,MYC,MYCN,NFIL3,PFKFB3,PLAT,PLAUR,RSAD2,SELE,SERPINE1,TNFSF10,TREML2 | 501 (19) |
| linsidomine | NA | chemical drug | Activated | 2.19e+00 | 3.0e-02 | ALB,GCLC,HMOX1,MYC,PTGS2 | NA |
| vitamin K3 | NA | chemical drug | Activated | 2.18e+00 | 0.0e+00 | ATF4,BMP6,FOS,HK2,HMOX1,IL1A,MAP1LC3B,MYC | 488 (21) |
| CHUK | 1.50e-01 | kinase | Activated | 2.18e+00 | 0.0e+00 | ATF3,BCL2L1,BMP2,CCL19,CCL2,Ccl2,CCL4,CDKN1A,CEBPD,CXCL10,CXCL2,CXCL3,CXCL6,CYP7B1,EREG,F3,FOS,GADD45B,GBP2,GBP4,HK2,HMOX1,IL12B,IL1A,ISG15,JUNB,LCN2,MGP,MMP9,Mt1,MYC,NFKBIA,NOCT,PPARGC1B,PTGS2,PTX3,RGS16,SELE,SOCS3,TGFA,TIMP3 | 414 (12) |
| nitric oxide | NA | chemical - endogenous mammalian | Activated | 2.18e+00 | 0.0e+00 | AR,ATF3,BCL2L1,CDKN1A,CTSH,CXCL10,DUSP1,ECE1,EDN1,FOS,GADD45A,GCLC,GNRH1,HMOX1,IER3,IL12B,JUNB,MMP9,Mt1,MYC,ODC1,PGF,PTGS2,SELE,SFN,SLC16A4,THBS1,TIMP3,TXNRD1 | 492 (20) |
| MLXIPL | -1.80e-01 | transcription regulator | Activated | 2.18e+00 | 2.8e-01 | ADGRE1,Ccl2,CPT1A,FASN,PCK1,PNPLA2,PNPLA3,PPARA,RGS16,TXNIP | NA |
| prexasertib | NA | chemical drug | Activated | 2.16e+00 | 0.0e+00 | ATF3,BTG2,CDKN1A,CSRNP1,DUSP1,EGR3,FOS,GADD45B,HMOX1,IER3,MMP9,MYC,NFKBIA,NGFR,PTGS2,SERPINE1,TXNIP,ZFP36 | 509 (20) |
| celecoxib | NA | chemical drug | Activated | 2.16e+00 | 0.0e+00 | AR,ATF4,BCL2A1,BCL2L1,BLK,CDKN1A,CIDEA,CLDN4,CRP,F3,FOS,GADD45A,HMOX1,KDR,MMP9,PTGS2,SELP,SERPINE1,TP73,WNT5A | 343 (12) |
| THBS4 | -1.70e-01 | other | Activated | 2.16e+00 | 0.0e+00 | ATF4,Ccl2,COL2A1,CRELD2,CXCL10,MMP16,MMP8,SELE | 314 (9) |
| STAT | NA | group | Activated | 2.16e+00 | 0.0e+00 | BCL2L1,CDKN1A,CEBPD,CRP,FOS,JUNB,SOCS2,SOCS3,TIMP1 | 426 (15) |
| nitrofurantoin | NA | chemical drug | Activated | 2.16e+00 | 0.0e+00 | ABCB11,ABCC2,ADAMTS1,ALB,BCL2L1,BTG2,Ccr2,COL2A1,CPT1A,CRP,CTSV,CXCL10,CXCL3,FGA,GADD45A,GJB1,HMOX1,HNF4A,HPX,IER3,IFRD1,ITIH4,LGALS3,LOX,Mt1,MYC,NFKBIA,ODC1,PLAT,PRKCB,SELENBP1,TIMP1,TIMP3,TNFRSF12A | NA |
| pomalidomide | NA | chemical drug | Activated | 2.16e+00 | 0.0e+00 | BCL11A,CD274,IL1A,IRF4,MYC | 481 (19) |
| TRPV4 | -1.50e-01 | ion channel | Activated | 2.15e+00 | 0.0e+00 | Ccl2,COL2A1,CXCL10,CXCL2,CXCL3,CXCL6,DUSP1,FOS,HMOX1,SOCS3,THBS1,TIMP1 | 423 (17) |
| cobalt chloride | NA | chemical reagent | Activated | 2.15e+00 | 0.0e+00 | ADAMTS1,ADORA2B,BHLHE40,CD274,CDKN1A,CXCR4,DDIT4,DUSP1,HIF3A,HK2,HMOX1,HSD11B2,PFKFB3,PLAUR,PTGS2,SPHK1 | 446 (17) |
| TNFSF11 | NA | cytokine | Activated | 2.15e+00 | 0.0e+00 | ADGRE1,ADORA2B,ADRA1A,BCL2A1,BCL2L1,C3AR1,CCL2,Ccl2,CCL4,CD14,CD83,CDC42EP4,CDKN1A,CXCL3,DOK2,DUSP1,F3,FOS,FOSL1,GADD45B,GCLC,HIPK2,HMOX1,IER3,IFRD1,IKBKE,IL12B,IL1A,IRF4,JUNB,LCN2,LIMK1,MMP9,MYC,NFIL3,NFKBIA,PLAUR,POR,PTGS2,RCL1,RGS16,S100A8,SDC4,SERPINE1,SLC7A7,SOCS3,STAT1,Tnfsf9,USP18 | 415 (16) |
| prednisolone | NA | chemical drug | Activated | 2.15e+00 | 0.0e+00 | ADORA2A,ATG16L2,BCL2L1,CCL2,Ccl2,CD163,CD40LG,CEBPD,CRP,CXCL10,CXCR4,DLL1,DUSP1,EDN1,EDNRA,FKBP5,GABARAPL1,GLI1,Irgm1,KIF9,MAP1LC3B,MYCN,NFIL3,NME5,PCK1,PLAT,PTGS2,SPON2,STAT1,TNFSF10,TP73,TRIM63,TXNIP,ZBTB16 | 455 (18) |
| PNPT1 | -2.20e-01 | enzyme | Activated | 2.14e+00 | 0.0e+00 | BCL2L1,CDKN1A,CMPK2,CXCL10,GBP2,GBP4,IFI44,Irgm1,ISG15,MYC,Oasl2,RNF213,STAT1,USP18 | 403 (13) |
| FOXO4 | 3.00e-02 | transcription regulator | Activated | 2.14e+00 | 0.0e+00 | Acan,ANXA3,BCL2L1,CDKN1A,FASN,FOXC1,GABARAPL1,GADD45A,GADD45B,IER3,MAP1LC3B,MMP9,PTPRC,SELL,SERPINB1,SERPINE1,SESN1,TXNIP | 500 (25) |
| RNASEH2B | -2.00e-01 | other | Activated | 2.14e+00 | 0.0e+00 | CDKN1A,CMPK2,CXCL10,IFI44,IFI44L,IFIT1,Igtp,IL12B,IRF4,ISG15,MX1,OAS2,PRKCH,PROCR,PTGS2,RSAD2,TRIM14,TXNIP,UBA7,USP18 | 80 (4) |
| ATF3 | 6.90e-01 | transcription regulator | Activated | 2.14e+00 | 0.0e+00 | ATF3,ATF4,AURKB,CD69,CD83,CDKN1A,GBP2,GBP4,IL12B,NUDT5,PCK1,Pln,PSAT1,RSAD2,SELE,SERPINE1,SLC11A1,TP73 | 522 (21) |
| ATP | NA | chemical - endogenous mammalian | Activated | 2.12e+00 | 0.0e+00 | ADAMTS9,Ccl2,CCL4,CD14,CD83,CXCL10,CXCL2,CXCL3,CXCR4,DUSP1,F3,FOS,GCLC,IL12B,IL33,LCN2,MYC,NRP1,PTGS2,SAT1,SELL,SERPINE1,SPHK1,THBS1,TRPC3,TRPV1,TXNIP | 506 (17) |
| IKZF2 | -6.00e-01 | transcription regulator | Activated | 2.12e+00 | 0.0e+00 | CD28,CD69,GZMA,IKZF3,IL4R,IRF4,LAG3,TNFRSF18 | NA |
| di(2-ethylhexyl) phthalate | NA | chemical toxicant | Activated | 2.10e+00 | 0.0e+00 | Acot1,AR,CCL2,Cyp4a14,FOS,IRAK2,MYC,PEX11A,POR,Slco1a1,ZFP36 | 402 (17) |
| IKBKG | -6.00e-02 | kinase | Activated | 2.10e+00 | 0.0e+00 | BMP2,Ccl2,CEBPD,CXCL10,CXCL2,CXCL3,CXCL6,CYP7B1,EREG,FCER2,FOS,GBP2,HK2,IKBKE,IL1A,ISG15,JUNB,LCN2,MGP,Mt1,NFKBIA,NOCT,PPARA,PTX3,RGS16,RYR2,SOCS3,TNFSF10 | 416 (12) |
| MTORC1 | NA | complex | Activated | 2.09e+00 | 1.0e-02 | ATF4,FASN,HK2,MYC,NFIL3,ODC1,PRF1,PTGS2 | 504 (23) |
| captopril | NA | chemical drug | Activated | 2.09e+00 | 0.0e+00 | ABCC2,CCR9,DLK1,F3,FGA,GNAI2,HMOX1,IER3,LCN2,LGALS3,MAOA,MMP9,PTGS2,RBM3,TIMP1,TNFRSF12A,UPP1 | 520 (25) |
| IGFBP5 | -2.90e-01 | other | Activated | 2.09e+00 | 0.0e+00 | BCL2L1,BHLHE40,F3,IRS1,PFKFB3,SERPINE1,SFN | 461 (22) |
| butaprost | NA | chemical drug | Activated | 2.09e+00 | 0.0e+00 | CCL4,MMP9,PTGS2,SOCS3,TGFBR3 | 428 (21) |
| DLL4 | -5.10e-01 | other | Activated | 2.08e+00 | 1.2e-01 | CXCR4,KDR,LYVE1,MYC,PDGFB | NA |
| Mek | NA | group | Activated | 2.08e+00 | 0.0e+00 | B3GNT5,BCL2L1,Ccl2,CDCA7,CDKN1A,CNTN3,CXCL10,EDEM1,EGR3,EPHA2,ERBB3,EREG,F3,FASN,FGFBP1,FOS,FOSL1,GALNT10,GBP2,IER3,IL12B,ITGA2B,JUNB,KDR,MAFF,MMP9,MS4A1,MYC,PLCD1,PTGS2,RND3,SEMA4C,SERPINE1,SLC43A3,SLC7A1,ST8SIA1,TET1,THBS1 | 484 (21) |
| S-nitroso-N-acetyl-DL-penicillamine | NA | chemical reagent | Activated | 2.07e+00 | 2.0e-02 | CCL2,CDKN1A,HMOX1,IL12B,MYC,PTGS2,TIMP1,TP73 | NA |
| CSF3 | 5.50e-01 | cytokine | Activated | 2.07e+00 | 0.0e+00 | ADCY5,ADGRE1,BCL2L1,C3AR1,Ccl2,CD14,CEBPD,CSF3R,CX3CR1,CXCL2,CXCL3,CXCR4,DLGAP1,EDN1,EGR3,FOS,GADD45A,GADD45B,GADD45G,GFI1,GZMB,HDC,HMOX1,IL12B,JAK3,LCN2,LTA,LTB,MMP8,MMP9,MYC,NCDN,NFIL3,ODC1,PRKCB,PRKCG,PTGS2,SELL,SLC20A2,SOCS3,TLR5,TNFSF10 | 361 (17) |
| salmonella minnesota R595 lipopolysaccharides | NA | chemical - endogenous non-mammalian | Activated | 2.07e+00 | 0.0e+00 | CCL2,Ccl2,CCL4,CD83,CEBPD,CMPK2,CXCL10,CXCL2,CXCL3,CXCL6,FOS,FOSL1,IKBKE,IL12B,IL1A,ISG15,JUNB,LPAR1,MAFF,Nes,NFKBIA,PTGS2,RSAD2,SERPINE1,SOCS3,Tnfsf9 | 339 (16) |
| adenosine | NA | chemical - endogenous mammalian | Activated | 2.06e+00 | 0.0e+00 | BCL2L1,CD28,CD69,CX3CR1,CXCR4,FOS,HMOX1,IL12B,PLAT,PTGS2,SERPINE1,SOCS3,TIMP1,TXNIP | 364 (15) |
| FOXA2 | 7.00e-02 | transcription regulator | Activated | 2.06e+00 | 0.0e+00 | ABCB1,ACTC1,ADH1C,AGR2,ALB,APOB,AQP1,CCL17,CCL24,CLCA1,CLDN4,CPT1A,CTHRC1,CXCR4,DDIT4,DLK1,GAL,HK2,HNF4A,IAPP,IL33,JOSD2,KCNJ11,Krt2,MLF1,Mt1,MUC5B,MYOCD,NR5A2,PCK1,PON1,PPARA,SFTPB,SLC10A1,SLC10A6,SPSB1,TRH,WNT5A,WNT7A | 523 (22) |
| NFkB (complex) | NA | complex | Activated | 2.04e+00 | 0.0e+00 | ABCB1,ADAMTS9,ADGRE1,ADORA2B,ANKRD1,AQP1,ATF3,B3GNT5,BCL11A,BCL2A1,BCL2L1,BMP2,CCL17,CCL2,Ccl2,CCL4,CD274,CD40LG,CD69,CD83,CDKN1A,CEBPD,CIITA,COL2A1,CREM,CRP,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DIO1,EDN1,F2RL1,F3,FCER2,FOS,G0S2,GADD45A,GADD45B,GBP2,GCLC,GFPT2,GRK5,HIF3A,HMOX1,HNF4A,IER3,IKBKE,IL12B,IL1A,IL24,IRF4,ISG15,JUNB,KDR,KRT17,KYNU,LCN2,LIF,LTA,LTB,MAP3K8,MEOX1,MMP9,MUC5B,MYC,MYLK3,NFKBIA,Oas1h,ODC1,PKP1,PLAUR,POU2F2,PPARA,PTGS2,PTX3,RGS16,RSAD2,SDC4,SELE,SERPINE1,SLC16A3,SLC2A5,SLC7A1,SLC7A5,SOAT1,SOCS3,TFPI2,TIMP1,TNFAIP6,TNFSF10,Tnfsf9,TRH,TRPC3,WNT5A,ZC3H12A,ZFP36 | 508 (16) |
| dorsomorphin | NA | chemical - kinase inhibitor | Activated | 2.04e+00 | 1.0e-02 | Ccl2,CD274,COL2A1,CXXC5,KDR,MUC5B,NR0B2,PCK1,PNPLA2,PNPLA3 | NA |
| TNF | 3.60e-01 | cytokine | Activated | 2.02e+00 | 0.0e+00 | ABCB11,ABCC2,Acan,ADAMTS4,ADAMTS5,ADCY5,ADORA1,ADORA2A,ADORA2B,ALB,ANKRD1,APCS,AQP1,AQP3,AR,ARRDC3,ARSI,ATF3,ATF4,ATP1A1,ATP2B4,BBOX1,BCL2A1,BCL2L1,BHLHE40,BMP2,BMP3,BMP6,BMPER,BPIFB1,BTG2,C1QTNF1,C3AR1,CA12,CCL17,CCL19,CCL2,Ccl2,CCL24,CCL28,CCL4,CCR3,CCR6,CD14,CD163,CD274,CD28,CD40LG,CD69,CD83,CDC42EP4,CDKN1A,CDO1,CEBPD,CERS6,CHRNA7,CHST7,CIB2,CIITA,CLDN11,CLDN4,CLDN5,COL2A1,CPT1A,CPT1B,CREB1,CREB3L3,CREM,CRISPLD2,CRP,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,CYP26B1,CYP7B1,DDIT4,DIO1,DUSP1,DUSP9,EDN1,EGR3,ELK3,EPHA2,EREG,ERN1,EXOC3L4,F2RL1,F3,FASN,FAT2,FCER2,FERMT1,FOS,FOSL1,FOSL2,G0S2,GADD45A,GADD45B,GADD45G,GBP2,GBP4,GCLC,GEM,GFPT2,GJB1,GLI1,GNAI2,HAS1,HAS3,HDC,HEPACAM,HIPK2,HK2,HMOX1,HNF4A,HSH2D,IAPP,IER3,IFIT1,IFITM2,IKBKE,IL12B,IL1A,IL1R2,IL21R,IL24,IL33,IL4R,IL6R,INHBA,IRAK2,IRF4,IRS1,ISG15,ITGB7,JUNB,KDR,KYNU,LCN2,LGALS12,LGALS3,LIF,LIMK1,LOX,LTA,LTB,LYVE1,MAFF,MAP2K6,MAP3K8,MCAM,MEOX1,MEOX2,MERTK,MGP,MMD,MMP16,MMP8,MMP9,Mt1,MUC5B,MX1,MYC,NEDD9,NFKBIA,NGFR,NKD2,NOCT,NR0B2,NR5A2,NRIP3,NRP1,OAS2,ODC1,OSMR,PCK1,PDGFB,PEMT,PEX11A,PGF,PGLYRP1,PIK3C2B,PLA1A,PLAT,PLAUR,PNPLA1,POU2AF1,PPARA,PPARGC1B,PPP1R3C,PROCR,PTGS2,PTPRC,PTPRN,PTX3,RASGRF1,RFLNA/ZNF664-RFLNA,RFX2,RGCC,RGS16,RND3,RSAD2,S100A8,SAT1,SCIN,SDC4,SELE,SELL,SELP,SERPINB1,SERPINE1,SFTPB,SH3TC2,SLC10A1,SLC11A1,SLC16A5,SLC7A1,Slco1a1,Slpi/Slpil2,SMO,SOAT1,SOCS2,SOCS3,SOX2,SPHK1,SPOCK1,SPSB1,STAT1,TBC1D8,TBX21,TFPI2,TGFA,THBS1,TIMP1,TIMP3,TINAGL1,TLR5,TNFAIP6,TNFRSF14,TNFRSF18,TNFRSF21,TNFRSF8,TNFSF10,TNFSF8,TREM3,TRIM15,TRIM63,TRPC3,TXNIP,TXNRD1,VIPR2,WNT5A,WNT7A,XDH,ZC3H12A,ZFP36 | 564 (18) |
| phorbol esters | NA | chemical - other | Activated | 2.02e+00 | 0.0e+00 | CXCL6,DUSP1,FOS,HK2,ITGAD,JUNB,LIF,MMP9,ODC1,PLAT,PRKCB,PRKCG,PTGS2,PTPRO,TGM1,TIMP1,TNFSF10,TRH | 450 (17) |
| PDGFB | -1.12e+00 | growth factor | Activated | 2.02e+00 | 3.0e-02 | AQP1,FOS,KCNA5,MMP9,MYC,PTGS2,THBS1,TIMP1 | NA |
| tetradecanoylphorbol acetate | NA | chemical drug | Activated | 2.01e+00 | 0.0e+00 | ABCB1,Acan,ADAMTS1,ADAMTS4,ADORA2A,ALB,ATF3,ATP2B4,AURKB,B3GNT5,BCL2A1,BCL2L1,BMP2,BMP6,BMP7,BTG2,C3AR1,C3orf52,CALCRL,CBS/LOC102724560,CCL2,Ccl2,CCL4,CCNA1,CCR3,CCR6,CD14,CD163,CD28,CD40LG,CD69,CDKN1A,CEMIP,CFAP46,CIITA,CLEC12B,CR2,CREB1,CREM,CSF3R,CTSH,CTSV,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,Cyp3a25 (includes others),DDIT4,DIO1,DIO2,DUSP1,DUSP8,ECE1,EGR3,EPHA2,EPHA4,EREG,ERRFI1,F3,FCER2,FGFBP1,FJX1,FKBP5,FOS,FOSL1,FOSL2,FSTL3,GABRP,GADD45B,GAL,GCLC,GEM,GLIS1,GNAI2,GNRH1,GPR55,GRK5,GZMB,HAS1,HDC,HK2,HMOX1,HNF4A,HSD17B2,HSH2D,IER3,IKBKE,IKZF3,IL12B,IL1A,IL22RA2,IL24,IL6R,INHBA,IRF4,ISG15,ITGA2B,ITGAD,JAK3,JUNB,KCNA5,KCNK2,LCN2,LIF,LIN7A,LTA,LTB,LYVE1,MAOB,MMP8,MMP9,MUC5B,MYC,NFIL3,NFKBIA,NOCT,NPR3,NRP1,ODC1,OSR2,PAX5,PCK1,PDK4,PER1,PLAT,PLAUR,Pln,PON1,POU2AF1,POU2F2,Ppp1r15a,PRF1,PRKCB,PRKCG,PRKCH,PTGIR,PTGS2,PTPRC,PTPRN,PTPRO,PTX3,RASGRP1,RGN,RGS16,S100A8,SDC4,SELE,SELL,SELP,SERPINE1,SETBP1,SFTPB,SIGLEC8,SLC11A1,SLC23A1,SLC28A3,SLC6A2,SLC7A1,SOCS3,SPHK1,SPN,STAT1,TBX21,TFPI2,TGFA,TGM1,THBS1,TIMP1,TLR10,TLR5,TMEM171,TNFAIP6,TNFRSF12A,TNFRSF18,TNFRSF21,TNFRSF8,TNFSF10,TPBG,TRH,UPP1,XCL1,XCR1,ZFP36 | 520 (16) |
| Cyp4a14 | -6.70e-01 | enzyme | Activated | 2.00e+00 | 0.0e+00 | Ccl2,CXCL10,CXCL3,IL1A | NA |
| ST3-Hel2A-2 | NA | chemical reagent | Activated | 2.00e+00 | 0.0e+00 | ATF3,FOS,GADD45A,IER3 | 197 (7) |
| erastin | NA | chemical drug | Activated | 2.00e+00 | 0.0e+00 | CDKN1A,GCLC,HMOX1,LCN2,MAP1LC3B | 418 (19) |
| 3-deoxy-2-octulosonic acid(2)-lipid A | NA | chemical - endogenous non-mammalian | Activated | 2.00e+00 | 1.0e-02 | Ccl2,CXCL10,PTGS2,SOAT1 | NA |
| fontolizumab | NA | biologic drug | Activated | 2.00e+00 | 1.0e-02 | ISG15,LAG3,MX1,RSAD2 | NA |
| SLC29A1 | -2.50e-01 | transporter | Activated | 2.00e+00 | 2.0e-02 | AQP3,CDKN1A,GADD45A,SESN1 | NA |
| PTGIS | 4.30e-01 | enzyme | Activated | 2.00e+00 | 2.0e-02 | CXCL2,CXCL3,CXCL6,PTGS2 | NA |
| IL2RA | 0.00e+00 | transmembrane receptor | Activated | 2.00e+00 | 4.0e-02 | FOS,GZMA,MYC,PRF1 | NA |
| HAVCR2 | -3.60e-01 | other | Activated | 2.00e+00 | 1.0e-01 | CDKN1A,CX3CR1,CXCR4,TBX21 | NA |
| RUVBL1 | -7.00e-02 | transcription regulator | Activated | 2.00e+00 | 2.4e-01 | GADD45B,SESN2,SOCS3,TRIM66 | NA |
| miR-29b-3p (and other miRNAs w/seed AGCACCA) | NA | mature microRNA | NA | 1.99e+00 | 5.0e-02 | ADAMTS15,CEMIP,FGFR4,FRAT2,GAS7,GPR37,MLF1,PDGFB,TBX21,TET1 | NA |
| RPS6KA4 | 9.00e-02 | kinase | NA | 1.99e+00 | 0.0e+00 | DUSP1,FOS,IL12B,JUNB | 477 (19) |
| 1-chloro-2-(2,2,2-trichloro-1-(4-chlorophenyl)ethyl)benzene | NA | chemical toxicant | NA | 1.99e+00 | 0.0e+00 | ARNT2,CDKN1A,CYP7B1,GADD45A,GADD45B | 378 (11) |
| cis-urocanic acid | NA | chemical drug | NA | 1.99e+00 | 3.0e-02 | ADAMTS1,GADD45B,KCNK1,PTGS2 | NA |
| C5 | -2.70e-01 | other | NA | 1.98e+00 | 0.0e+00 | BCL2L1,Ccl2,CCL4,CXCL2,CXCL3,SOCS3 | 463 (19) |
| zidovudine | NA | chemical drug | NA | 1.98e+00 | 0.0e+00 | CCL2,CDKN1A,CPT1A,IL12B,MYC,STAT1 | 315 (16) |
| cyclooxygenase | NA | group | NA | 1.98e+00 | 2.0e-02 | FOS,HMOX1,LIF,PTGS2 | NA |
| MAPK11 | -8.00e-02 | kinase | NA | 1.98e+00 | 2.0e-02 | FOS,HMOX1,PTGS2,TBX21,TIMP1 | NA |
| LGR5 | -5.40e-01 | transmembrane receptor | NA | 1.98e+00 | 3.0e-02 | BCL2L1,F2RL1,GLUL,SLC13A3 | NA |
| CDK9 | 3.80e-01 | kinase | NA | 1.98e+00 | 0.0e+00 | CDKN1A,CXCL2,CXCR4,FOS,FRAT2,MMP9,MYC,NFKBIA,ODC1,PDK4,SELE,WNT5A | 458 (16) |
| ACKR3 | 4.10e-01 | G-protein coupled receptor | NA | 1.98e+00 | 1.3e-01 | CDKN1A,CXCR4,IL24,MYC | NA |
| BMP15 | -4.10e-01 | growth factor | NA | 1.98e+00 | 3.0e-02 | EREG,PTGS2,PTX3,TNFAIP6 | NA |
| CYP2E1 | -1.20e-01 | enzyme | NA | 1.97e+00 | 0.0e+00 | C3AR1,Ccl2,CD14,Cyp4a14,GCLC,HMOX1,PON1,PTGS2 | 463 (20) |
| C6 | -3.10e-01 | other | NA | 1.97e+00 | 0.0e+00 | Ccl2,CXCL2,CXCL3,SELP | 434 (12) |
| MED12 | -3.10e-01 | transcription regulator | NA | 1.97e+00 | 1.0e-02 | ANKRD1,EREG,GLI1,LIF,MYC | NA |
| NCD-38 | NA | chemical reagent | NA | 1.97e+00 | 2.0e-02 | ATF3,ATF4,ERN1,SOX2 | NA |
| (1S,2R)-NCL-1 | NA | chemical reagent | NA | 1.97e+00 | 2.0e-02 | ATF3,ATF4,ERN1,SOX2 | NA |
| MAPK13 | 1.00e-01 | kinase | NA | 1.97e+00 | 3.0e-02 | CDKN1A,FOS,IL12B,MAP3K8 | NA |
| TCF | NA | group | NA | 1.96e+00 | 0.0e+00 | ABCB1,ADGRG2,ARL4A,BCL2L1,DIO2,EDN3,FOS,HSD17B2,IRS1,JUNB,LGALS3,MYC,PTGS2,RCN1,SERPINE1,SFN,SLC6A2 | 407 (12) |
| WR 1065 | NA | chemical drug | NA | 1.96e+00 | 6.0e-02 | CDKN1A,GADD45A,KDR,MYC | NA |
| PCGEM1 | NA | other | NA | 1.96e+00 | 1.9e-01 | FASN,HK2,PDHA1,PDK4 | NA |
| PIN1 | 7.00e-02 | enzyme | NA | 1.96e+00 | 3.0e-02 | ATF4,BCL2A1,CD274,CDKN1A,FASN,MMP9,MYC,PTGS2,TIMP1 | NA |
| F7 | -2.60e-01 | peptidase | NA | 1.96e+00 | 0.0e+00 | AR,Ccl2,CXCL2,F3,FOS,FOSL1,GADD45A,LIF,MYC,PLAUR,PTGS2,RND3,ZFP36 | 408 (15) |
| flufenamic acid | NA | chemical drug | NA | 1.95e+00 | 0.0e+00 | AR,IL24,PTGS2,SELL | 392 (14) |
| AMH | -1.30e-01 | growth factor | NA | 1.95e+00 | 6.0e-02 | BTG2,CDKN1A,CXCL2,IER3 | NA |
| HEIH | NA | other | NA | 1.95e+00 | 7.0e-02 | BCL2L1,DUSP1,FOS,GADD45B | NA |
| acetaldehyde | NA | chemical - endogenous mammalian | NA | 1.95e+00 | 2.0e-02 | FOS,MYC,PPARA,TIMP1 | NA |
| NF-Y | NA | complex | NA | 1.95e+00 | 8.0e-02 | ABCB1,ALB,CBS/LOC102724560,FASN,GADD45A,JUNB,LPIN1,SHOX2 | NA |
| IRGM | NA | enzyme | NA | 1.95e+00 | 0.0e+00 | CMPK2,CXCL10,CXCL2,CXCL3,CXCL6,GBP4,IFI44,IFI44L,IFIT1,IKBKE,IL1A,ISG15,MAP3K6,MX1,NFKBIA,OAS2,RSAD2,SOCS3,STAT1,TNFAIP6,TNFRSF18,TNFSF10,TRIM14,UBA7,USP18,ZBP1 | 412 (18) |
| KLF10 | 1.30e-01 | transcription regulator | NA | 1.95e+00 | 0.0e+00 | CDKN1A,IL12B,ITGAD,SERPINE1,TBX21,TNFSF8 | 444 (17) |
| doxifluridine | NA | chemical drug | NA | 1.95e+00 | 1.0e-02 | AQP3,CDKN1A,GADD45A,SESN1 | NA |
| P2RY2 | 1.00e-01 | G-protein coupled receptor | NA | 1.95e+00 | 0.0e+00 | BCL2L1,Ccl2,CDKN1A,F3,PTGS2,SERPINE1,SESN2 | 398 (17) |
| streptozocin | NA | chemical drug | NA | 1.95e+00 | 0.0e+00 | ABCB1,ABCB11,ADORA2A,ALB,AR,ATF3,ATF4,ATP1A1,ATP1B1,BCL2L1,CBS/LOC102724560,Ccl2,CD163,CDKN1A,CIDEA,CPT1A,CPT1B,CREB1,CREM,CXCL2,Cyp4a14,ENO3,FABP3,FASN,FGFR4,FOS,GABARAPL1,HMOX1,HNF4A,HSD11B2,IRS1,KCNJ11,LGALS3,MAP1LC3B,MC5R,MMP9,NEXN,NTRK3,OGT,PCK1,PDK4,Pmaip1,PTGS2,PTPRN,RPS6KA6,SELE,SELP,SERPINE1,SESN2,SLC2A5,SLC6A12,SLC6A2,TRPC3,TRPV1,TXNIP,UBC | 455 (22) |
| eflornithine | NA | chemical drug | NA | 1.95e+00 | 1.0e-02 | APOB,ATF4,CDKN1A,LGALS3,MYCN,ODC1,SERPINE1 | NA |
| EGFR | -4.00e-02 | kinase | NA | 1.94e+00 | 0.0e+00 | ANXA8/ANXA8L1,AR,B3GNT5,BCL2L1,CCL2,CD274,CDKN1A,CNTN3,CXCL10,CXCR4,DUSP1,EDEM1,EGR3,EPHA2,ERBB3,EREG,F2RL1,F3,FASN,FOS,FOSL1,FOSL2,GADD45A,GALNT10,GZMB,HDC,HK2,HSD11B2,IER3,IL33,JUNB,KRT17,LCN2,MCAM,MMP9,MYC,NFKBIA,ODC1,OSMR,PBK,PLAT,PLAUR,PRF1,PTGS2,RCL1,RND3,SEMA7A,SERPINE1,SLC7A1,SLC7A5,SOCS3,SOX2,SPHK1,TGFA,THBS1,TNFAIP6,TXNIP,ZEB2 | 516 (19) |
| IL1 | NA | group | NA | 1.94e+00 | 0.0e+00 | ABL1,ADAMTS1,ADAMTS4,ADAMTS5,ALB,AR,BHLHE40,BMP2,CCL2,Ccl2,CCL4,CCR6,CD40LG,CDKN1A,CEBPD,COL2A1,CPT1A,CRP,CXCL10,CXCL2,CXCL3,DUSP1,EDN1,F3,FOS,HMOX1,IL1R2,IL2RB,IL33,IL4R,INHBA,IRF4,KYNU,LIF,LOX,MAP2K6,MMP9,MYC,NGFR,ODC1,PPARA,PTGS2,RBP4,SDC4,SELE,SELL,SELP,SERPINE1,SFTPB,SOCS3,SPHK1,TIMP1,TNFAIP6,TNFSF10,WNT5A,XDH | 442 (14) |
| ECSIT | -1.20e-01 | transcription regulator | NA | 1.94e+00 | 0.0e+00 | CD83,HMOX1,IER3,JUNB,NFKBIA,PLAUR,PTGS2 | 384 (14) |
| Endothelin | NA | group | NA | 1.93e+00 | 1.0e-02 | EDN1,FOS,MYC,PTGS2 | NA |
| IRF2BP2 | 3.00e-01 | transcription regulator | NA | 1.93e+00 | 0.0e+00 | BCL2A1,CD14,CD180,CD274,CD3G,Csprs (includes others),CYSLTR1,DNASE1L3,GBP5,GZMA,HMOX1,LILRB3,LY86,Milr1,MMP8,Retnlg,S100A8,SELP,STAP1,TIMP1,ZNF705A | NA |
| CIRBP | 7.60e-01 | translation regulator | NA | 1.93e+00 | 6.0e-02 | CXCL2,CXCL3,MYC,PTGS2 | NA |
| WNT1 | NA | cytokine | NA | 1.93e+00 | 1.0e-02 | APCDD1,CDKN1A,DKK2,DLL1,EDN1,Elf5,FOS,GADD45G,HNF4A,JUNB,Meis1,MYC,PTGS2,SERPINE1,Tnfsf9 | 451 (18) |
| HDC | -9.60e-01 | enzyme | NA | 1.93e+00 | 1.0e-02 | FOS,HDC,PTGS2,SELP | NA |
| THEM6 | -2.80e-01 | other | NA | 1.93e+00 | 1.1e-01 | ATF3,ATF4,EDEM1,NPC2 | NA |
| prostaglandin E2 | NA | chemical - endogenous mammalian | NA | 1.93e+00 | 0.0e+00 | Acan,ADAMTS1,ADAMTS4,ADORA2B,AQP3,ATF3,ATP1A1,BCL2L1,BMP2,CALCRL,CCL2,Ccl2,CCL4,CCR6,CD14,CD274,CD69,CD83,CDKN1A,CEBPD,CIITA,CREM,CXCL10,CXCL3,CXCR4,DLL1,DUSP1,DYNLL1,EREG,F2RL1,FASN,FOS,FOSL1,FOSL2,FSTL3,GBP5,H2-T24,HDC,HMOX1,IER3,IFITM5,IL12B,IL1A,IL1R2,IRF4,JAK3,LOX,MAP3K8,MMP9,MYC,NEDD9,NFIL3,NFKBIA,NR5A2,NRP1,OSBPL3,PDE4A,PGF,PKN1,PTGS2,S100A8,SELL,SLC5A1,SOCS2,SOCS3,SOX2,SPHK1,TBX21,TGFA,TGFBR3,THBS1,TNFAIP6 | 534 (18) |
| HGF | 4.00e-02 | growth factor | NA | 1.93e+00 | 0.0e+00 | ACKR4,ADAMTS1,ADGRL2,ADORA2A,ARRDC3,ATF3,AURKB,BCL2A1,BCL2L1,BMP2,CALCRL,CCL2,Ccl2,CCL4,CD28,CDKN1A,COL2A1,CXCL2,CXCR4,DDX11,DUSP1,DYNLL1,EDN1,EPHA4,ERRFI1,F3,FANCG,FKBP5,FOS,FOSL1,GEM,GRB14,GRK5,HK2,HMOX1,IER3,IL12B,INHBA,ISG15,JUNB,KRT17,LCN2,LTA,LYVE1,MAP3K8,MEOX2,MERTK,MMP8,MMP9,MYC,NR0B2,NR5A2,NRP1,OSMR,PCK1,PEMT,PGF,PLAUR,PTGS2,SELE,SERPINE1,SIX4,SLC7A1,SOCS2,SOCS3,SOX2,TBC1D8,TGFA,THBS1,TIMP1,TIMP3,TNFAIP6,TRIB1,XCR1,ZFP36 | 521 (17) |
| atorvastatin | NA | chemical drug | NA | 1.93e+00 | 0.0e+00 | ABCB1,ABCC2,AGR2,APOB,BCL2L1,BMP2,BMP6,CCL19,CCL2,Ccl2,CD40LG,CD69,CRP,CXCR4,DMC1,DUSP1,EDN1,EDNRA,ERN1,F3,FOS,GADD45B,GLI1,HMOX1,IER3,JUNB,MMP9,MYOCD,NR0B2,PLAT,PRELID3A,PTGS2,SELE,SELP,SERPINE1,SLC10A1,SLCO1C1,USP49,ZFP36,ZNF786 | 458 (13) |
| ELK1 | 1.60e-01 | transcription regulator | NA | 1.92e+00 | 0.0e+00 | BCL2L1,BMP2,CCL2,CDKN1A,EGR3,FOS,FOSL1,JUNB,MMP9,NUPR1,PTGS2,SOCS3,SOX18,THBS1,ZFP36 | 495 (20) |
| TRIM24 | NA | transcription regulator | NA | 1.92e+00 | 0.0e+00 | CCL4,CMPK2,CXCL10,FLRT3,GBP2,GBP4,GLUL,IFI44,Igtp,Irgm1,ISG15,LGALS3,SERPINE1,SOCS2,STAT1,UBA7,USP18 | 426 (18) |
| MED13 | -1.50e-01 | transcription regulator | NA | 1.92e+00 | 1.0e-02 | ANKRD1,CIB2,CIDEA,FASN,LIF,MYC,Sik1 | NA |
| eicosapentenoic acid | NA | chemical drug | NA | 1.91e+00 | 0.0e+00 | BCL2L1,CCL2,CD83,CEBPD,CIDEA,FOS,HMOX1,IL12B,IL1R2,KCNJ11,MMP8,MMP9,PDK4,PNPLA2,PPARA,PTGS2,SERPINE1,SOAT1 | 458 (20) |
| mir-142 | NA | microRNA | NA | 1.91e+00 | 0.0e+00 | CXCL3,GBP2,GBP4,GBP5,GBP7,IL21R,IL2RB,ITGAD,LRRC32,MCAM,NRP1,SELL,SLAMF6,SOCS3,SOX2,STAT1,TNFRSF13C,TNFSF10 | 281 (12) |
| TFPI2 | 2.02e+00 | other | NA | 1.90e+00 | 0.0e+00 | ABCB1,ADAMTS4,ATF3,BTG2,CXCL10,CXCL2,DIO2,GADD45B,JUNB,Ppp1r15a | 268 (9) |
| growth factor | NA | group | NA | 1.89e+00 | 0.0e+00 | DUSP1,FOS,GLUL,MYC,PTGS2,SELL,SPHK1 | 394 (20) |
| betamethasone | NA | chemical drug | NA | 1.89e+00 | 0.0e+00 | ABCB1,ASPA,CRISPLD2,HIF3A,KDR,SFTPB,TIMP3 | NA |
| interferon alfacon-1 | NA | biologic drug | NA | 1.89e+00 | 0.0e+00 | CD69,GZMA,HIPK2,IL1R2,MAFF,STK17B,XPO1 | NA |
| isoprenaline | NA | chemical drug | NA | 1.89e+00 | 1.0e-02 | ABLIM1,FOS,KCNJ5,MAP1LC3B,MMP9,PER1,PNPLA2,Sry | 368 (16) |
| RHOA | 3.00e-02 | enzyme | NA | 1.89e+00 | 7.0e-02 | BCL2L1,CDKN1A,CXCL10,FOS,MMP9,PDHA1,PPARA,RND3,TBX21,TNFRSF18 | NA |
| carbonyl cyanide m-chlorophenyl hydrazone | NA | chemical toxicant | NA | 1.88e+00 | 0.0e+00 | ATF4,BMP6,CTSV,DDIT4,ERRFI1,FBXL13,HK2,IL1A,LCN2,MAP1LC3B,MYCT1,PTGS2,RND3,SELP,SERPINE1 | 474 (20) |
| epigallocatechin-gallate | NA | chemical drug | NA | 1.88e+00 | 0.0e+00 | ADORA2A,APOB,AR,BCL2L1,CCL17,CCL2,CDKN1A,CLDN5,CXCL10,CXCL3,EDN1,F3,FOS,FOSL1,FOSL2,GADD45A,GADD45B,GBP4,GCLC,GJB2,GLI1,HMOX1,IL12B,IL1A,ISG15,JAK3,JUNB,KDR,MMP9,MUC5B,MYC,NFKBIA,PTGS2,RBP4,SERPINE1,SLC5A1,STAT1,TIMP1,TNFSF10 | 488 (15) |
| aflatoxin B1 | NA | chemical - endogenous non-mammalian | NA | 1.88e+00 | 5.0e-02 | Akr1b10,AURKB,Cd209b,CDKN1A,CXCL2,GCLC,Gsta1,GULP1,INHBA,LAMA5,PBK,PLG,Pln,PPP1R1B,PSAT1,RAD18,RCN1,SERPINB1,SLC5A1,ST8SIA1,TRIM16,TRPV1,TXNRD1 | NA |
| dimethyl itaconate | NA | chemical reagent | NA | 1.88e+00 | 0.0e+00 | ATF3,ATF4,ERN1,GCLC,HMOX1,ISG15,LCN2,RSAD2 | NA |
| TFEB | 1.50e-01 | transcription regulator | NA | 1.87e+00 | 1.0e-01 | CALCRL,CCL17,CCNA1,CNTRL,CXCL2,CXCL3,CXCL6,EREG,FASN,FJX1,FOS,FOSL1,IL33,LIF,LTA,MYC,PTX3,TNFAIP6,TNFRSF18,TNFRSF21,UPP1,XPO1 | NA |
| phenylephrine | NA | chemical drug | NA | 1.87e+00 | 0.0e+00 | ANKRD1,CPT1B,DIO2,DUSP1,EDN1,EDNRA,FOS,GCLC,HMOX1,MYC,PDK4,PRKCB,PTGS2,RAPGEF3,THRB | 420 (19) |
| estradiol benzoate | NA | chemical drug | NA | 1.86e+00 | 1.0e-02 | AR,Ccl2,CPT1B,FOS,GJB1,GNRH1,HCRTR1,PLAT,PTGS2,RBP4 | NA |
| 5-azacytidine | NA | chemical drug | NA | 1.86e+00 | 0.0e+00 | ABCB1,BCL2L1,CDKN1A,CIITA,DLK1,DUSP1,EPHA2,EZH2,F3,FANCG,FOSL1,GADD45A,GATA5,HK2,INHBA,KDR,KRT17,KRT81,LOX,MAFF,Mt1,MYC,NTRK3,PCDHA4,PRF1,PTGS2,RASSF1,RPS6KA6,SLC26A3,SLC7A5,SOCS3,SOX2,SPHK1,TFPI2,THBS1,TNFRSF18,TP73,UPP1 | 465 (21) |
| norepinephrine | NA | chemical - endogenous mammalian | NA | 1.85e+00 | 0.0e+00 | CAMK1G,Ccl2,COQ10B,CREM,CRY2,CXCR4,DCLK3,DIO2,DUSP1,EDN1,FOS,FOSL2,GEM,GNRH1,GRK5,HMOX1,IL12B,IRAK2,LRRN3,MCAM,MMP9,NFKBIA,PDE10A,PER1,PTGS2,RBP4,Rcan1,SERPINE1,Sik1,SLC6A17,SLC6A2,TINAGL1 | 444 (18) |
| calcitriol | NA | chemical drug | NA | 1.85e+00 | 0.0e+00 | ABCB1,ABL1,ABLIM1,ACKR4,AFAP1L2,AGR2,ALB,AR,ARHGEF28,ATP2B4,BCL2L1,BMP7,Ccl2,CCNA1,CD14,CD163,CD28,CD69,CDKN1A,CEBPD,CPT1A,CXCL10,CXCL2,CXCL3,CXCL6,CYP46A1,DLL1,DUSP1,EDN1,ERBB3,ERRFI1,EZH2,F2RL1,F3,FAM107A,FASN,FCER2,FGFBP1,FNDC5,FOS,FTL,GADD45A,GADD45G,GEM,GNAI2,GRK5,HIPK2,HK2,HSD17B2,IER3,IFI44L,IKBKE,IL12B,IL1A,IRF4,ISG15,ITGB7,JUNB,KCNH1,LCN2,LPAR1,LRRC17,LRTM2,MAOA,MX1,MYC,MYCN,NEDD9,NFKBIA,NUPR1,ODC1,PBK,PDHA1,PDK4,POR,PRKCB,PTGS2,RGCC,RNF144A,RSAD2,RUNX1T1,S100A8,SERPINB1,SLC30A10,SLC7A7,SOAT1,SOCS3,SPON2,TBX21,THBS1,TINAGL1,TNFSF10,TP73,TXNIP,WNT11,XPO1 | 520 (17) |
| 9,10-dimethyl-1,2-benzanthracene | NA | chemical toxicant | NA | 1.85e+00 | 0.0e+00 | BCL2L1,CDKN1A,CXCL2,CXCL3,EPHA2,GADD45A,GCLC,MMP9,PTGS2,S100A8,SERPINE1,TGFA | 482 (18) |
| beta-estradiol | NA | chemical - endogenous mammalian | NA | 1.84e+00 | 0.0e+00 | ABCB1,ABCB11,ABL1,ABLIM1,ACER2,Acot1,ACOX2,ACTC1,ADAMTS1,ADAMTS4,ADAMTS5,ADGRG2,ADH1C,ADORA1,ADORA2A,ADRA1A,ALB,ANO2,ANXA3,APCDD1,AQP1,AR,ARHGEF15,ARHGEF28,ARL4A,ARNT2,ASB2,ATF3,ATP1B1,BCL2A1,BCL2L1,BHLHE40,BMP2,BMP6,BTG2,C1orf226,CA12,CAP2,CAPN13,CBS/LOC102724560,CCDC146,CCDC170,CCL2,Ccl2,CCL4,CCNA1,CCR3,CD14,CD274,CD69,CDC42EP4,CDCA7,CDH15,CDKN1A,CDR2,CEBPD,CKMT1A/CKMT1B,CLCA1,CLDN11,CLDN4,CLDN5,CPA2,CPT1A,CPT1B,CREB1,CREM,CRP,CSF3R,CTSH,CUBN,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,CXXC5,CYP26B1,DDIT4,DIO1,DLL1,DUSP1,DYNLL1,Eda,EDN1,EGR3,ELK3,ENC1,ERBB3,EREG,ERRFI1,EZH2,F2RL1,F3,FABP3,FAM107A,FAM163B,FASN,FBXO10,FGFBP1,FJX1,FLRT3,FNDC5,FOS,FOSL1,FOSL2,FOXC1,GAB2,GABRP,GADD45A,GADD45B,GADD45G,GAL,GBP2,GCLC,GEM,GHRHR,GJB1,GJB2,GLI1,GLIS1,GLUL,GNRH1,GRHL1,GRIK4,GRK5,GZMA,H6PD,HAPLN2,HCRTR1,HMOX1,HPCAL1,HS3ST5,HSD11B2,HSD17B2,HUNK,HYAL3,ICAM5,ID4,IER3,Ifgga2l1/RGD1309362,IFRD1,IKZF3,IL12B,IL1A,IL1R2,IL24,IL4R,IL6R,INHBA,IRF4,IRS1,ISG15,ITGA7,ITIH4,JUNB,KAZN,KCNF1,KCNK5,KCNN3,KDR,KLHL38,Klre1,Klrk1,KRT17,KRT7,KRT81,KYNU,LARP6,LCN2,LGALS3,LIF,LIMK1,LIN7A,LOX,LPIN1,LTB,MACC1,MAOA,MAOB,MAP2K6,MAP3K8,MCAM,MERTK,MGP,MMD,MMP9,MUC5B,MX1,Mx2,MYC,MYCN,MYLK3,NEDD4L,NEDD9,NELL2,NFKBIA,NFYA,NGFR,NPR3,NR0B2,NR5A2,NRIP3,NRP1,NRTN,NTRK3,NUPR1,Oasl2,ODC1,OSBPL3,OTUB2,OVOL2,P4HA1,P4HA2,PBK,Pcp4l1,PDGFB,PDGFD,PDK4,PEMT,PEX11A,PGLYRP1,PHACTR1,PHYHIPL,PIK3C2B,PKNOX2,PLAT,PLAUR,PLXNA4,PPARA,PPARGC1B,PPL,PPP1R1B,PPP1R3C,PPP2R2B,PPP3R1,PRKCB,PRKCH,PROCR,PRSS35,PSAT1,PTGER3,PTGS2,PTPRN,PTX3,RAMP3,RASGRF1,RASGRP1,RASSF10,RBM14,RBM24,RBP4,Rcan1,RCL1,RCN1,RERG,RGS16,RGS18,RND3,RPS6KA6,RYR2,SAT1,SBK1,SCN4A,SDC4,SEC14L2,SELE,SELENBP1,SELP,SEMA7A,SERPINB1,SERPINE1,SERTAD4,SEZ6,SFN,SHC2,SIGLEC8,SLC10A1,SLC13A3,SLC13A4,SLC16A5,SLC20A2,SLC30A3,SLC38A2,SLC38A3,SLC6A13,SLC6A17,SLC7A5,Slpi/Slpil2,SMPD3,SOCS2,SOCS3,SOSTDC1,SOX18,SPEG,SPHK1,SPN,SPOCK1,SSTR4,ST8SIA1,STAT1,STBD1,SYBU,SYT6,TCN2,TFPI2,TGFA,TGFBR3,THBS1,THRB,TIMP1,TIMP3,TNFAIP6,TNFAIP8L3,TNFRSF21,TNFSF8,TREML2,TRIB1,TRPC3,TRPV1,TXNIP,TXNRD1,UCK2,VIPR2,WNT11,WNT5A,WNT7A,XPO1,ZBTB16,ZEB2,ZFHX2,ZFP36 | 679 (21) |
| TSH | NA | complex | NA | 1.84e+00 | 0.0e+00 | Ccl2,CDKN1A,DIO1,FOS,JUNB,KDR,Mt1,MYC,SOCS3,WNT5A | 467 (19) |
| JQ1 | NA | chemical reagent | NA | 1.84e+00 | 0.0e+00 | ADORA2A,BCL2L1,Ccl2,CD274,CLEC10A,CXCL3,CXCR4,FOS,GADD45G,IFIT1,IL24,IRF4,ISG15,MACC1,MAP1LC3B,MAP2K6,MX1,MYC,MYCN,NFKBIA,NRP1,Oasl2,P2RY14,SOCS3,TNFRSF14,TNFSF10,VSTM5 | 534 (16) |
| 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine | NA | chemical - endogenous mammalian | NA | 1.83e+00 | 0.0e+00 | CCL2,Ccl2,CD83,F3,HMOX1,IL12B,OSGIN1,PON1,PTGS2,SELE | 344 (20) |
| leukotriene D4 | NA | chemical - endogenous mammalian | NA | 1.83e+00 | 0.0e+00 | ADAMTS1,APOLD1,ATF3,BMP2,CCL2,CCL4,CREM,CXCL2,CYSLTR1,DUSP1,EGR3,F3,FOSL2,GEM,MAP3K8,NEDD9,PDK4,PTGS2,SELE,ZFP36 | 435 (20) |
| AGTRAP | 3.60e-01 | G-protein coupled receptor | NA | 1.82e+00 | 0.0e+00 | Ccl2,FOS,HK2,HMOX1,SLC6A2 | 406 (19) |
| IL-1R | NA | group | NA | 1.82e+00 | 0.0e+00 | CXCL2,CXCL3,EREG,IL1A,MMP8,MMP9,PLAUR,SELE,SERPINE1,TIMP1 | 309 (14) |
| mitomycin C | NA | chemical drug | NA | 1.81e+00 | 7.0e-02 | ATF3,BCL2L1,BTG2,CDKN1A,GADD45A,MCAM,SESN2 | NA |
| torkinib | NA | chemical drug | NA | 1.81e+00 | 0.0e+00 | ADAMTS1,ADGRL2,ANKRD1,ATF3,AURKB,BMP2,CCNA1,CPT1A,CXCL6,DCLRE1B,DDIT4,EDN1,FOSL1,FOXC1,IFRD1,IL24,IL6R,INHBA,LIF,PTGS2,RGCC,SDC4,SERPINB1,SFPQ,TMEM119,TXNIP | 450 (21) |
| GPR174 | -9.40e-01 | G-protein coupled receptor | NA | 1.81e+00 | 0.0e+00 | ARID5A,BTLA,CBLB,CD180,CD22,CHST3,CIITA,CR2,CREM,FCER2,P2RY10,SERPINB1,Sik1,STAP1,STK17B | NA |
| CAMP | 7.00e-02 | other | NA | 1.81e+00 | 0.0e+00 | BCL2L1,CCL2,Ccl2,CCL4,CD83,CSF3R,CXCL10,CXCL3,CXCR4,IL12B,IL1A,IL1R2,PTGS2,STAT1,TBX21,XCL1 | 369 (17) |
| SMAD1 | 4.60e-01 | transcription regulator | NA | 1.80e+00 | 0.0e+00 | BCL2L1,BTG2,CDKN1A,COL2A1,CXCL2,CXCL3,GADD45B,ID4,MYC,PDGFB,SELE | 537 (23) |
| NPM1 | 2.60e-01 | transcription regulator | NA | 1.80e+00 | 0.0e+00 | BMP2,CAMK1D,CCL2,Ccl2,CCL4,CXCL2,CXCL3,DLL1,EGR3,F3,GEM,HMOX1,IL1A,INHBA,JUNB,LIF,LOX,MMP8,MMP9,PDGFB,PGF,SDC4,SERPINF2,TRIB1,WNT5A,XDH,ZC3H12A | 448 (19) |
| ATF2 | -6.00e-02 | transcription regulator | NA | 1.80e+00 | 1.0e-02 | ATF3,BCL2A1,BCL2L1,CD79A,DUSP1,DUSP8,FOS,GADD45A,NUPR1,PCK1,PTGS2 | NA |
| lovastatin | NA | chemical drug | NA | 1.80e+00 | 0.0e+00 | ADAMTS1,ALB,AR,ATF3,ATF4,BCL2L1,CCL2,CDKN1A,CIITA,CXCL10,EBNA1BP2,ENC1,FASN,HMOX1,IL1A,LIF,MYC,PLAT,PTGS2,SDC4,SERPINE1,TBX21,TNFRSF8 | 532 (19) |
| hydrocortisone | NA | chemical - endogenous mammalian | NA | 1.80e+00 | 0.0e+00 | ANKRD1,CCL17,CCL2,CD163,CEBPD,CXCR4,ERRFI1,GADD45B,GLUL,H6PD,INHBA,LOX,Mt1,NFKBIA,PLAT,PLG,PTGS2,S100A8,SELE,SERPINE1,SMO | 571 (17) |
| NADPH oxidase | NA | complex | NA | 1.79e+00 | 0.0e+00 | CCL2,EDN1,F3,FOS,HMOX1,MMP9,PTGS2,SERPINE1,TGFA | 401 (16) |
| BCR-ABL1 | NA | fusion gene/product | NA | 1.79e+00 | 0.0e+00 | AURKB,BCL2A1,BCL2L1,BLK,CCL2,CSF3R,CXCR4,HK2,HMOX1,ITGA2B,LCN2,MS4A1,MYC,PRKCB,SGMS1,SOCS2,TNFSF10 | 440 (19) |
| anisomycin | NA | chemical - endogenous non-mammalian | NA | 1.79e+00 | 0.0e+00 | ABCB1,AQP1,ATF3,BCL2L1,CDKN1A,DUSP1,DUSP8,FOS,IRS1,JUNB,PLAUR,SERPINE1 | 463 (21) |
| TIRAP | 1.20e-01 | other | NA | 1.79e+00 | 0.0e+00 | CCL4,CXCL10,CXCL2,CXCL3,CXCL6,IL12B,PTGS2,SELE | 313 (13) |
| TAL1 | 4.00e-02 | transcription regulator | NA | 1.79e+00 | 7.0e-02 | ARVCF,AZGP1,BHMT2,C3AR1,CCR9,CD69,CDKN1A,CEP70,CIB2,EPB42,IKZF3,LRRN3,MYC,NFYA,PTPRCAP,RNASE6,TNFSF10,ZC3H12A | NA |
| methylnitronitrosoguanidine | NA | chemical toxicant | NA | 1.78e+00 | 0.0e+00 | BTG2,CDKN1A,GADD45A,PLAT,SERPINE1,TNFSF10 | 467 (23) |
| CXCL12 | -4.50e-01 | cytokine | NA | 1.78e+00 | 0.0e+00 | BCL2L1,BMP2,BMP6,CCL2,CD14,CD3G,CD40LG,CD69,CXCL10,CXCR4,FOS,IL1A,IL24,JUNB,MMP9,MYC,Podxl,PTGS2,RBM14,RYR2,SELE,SOCS2,SOCS3,SORBS3,THBS1,TIMP1,TNFSF10,ZBTB16 | 396 (15) |
| ADP | NA | chemical - endogenous mammalian | NA | 1.78e+00 | 0.0e+00 | CCL4,CREM,F3,FOS,HMOX1,SELP,SERPINE1 | 453 (21) |
| calcimycin | NA | chemical reagent | NA | 1.77e+00 | 0.0e+00 | AR,ATF3,CD14,CD83,DDIT4,FOS,FOSL1,IL12B,INHBA,IRF4,JUNB,LCN2,LTA,MAP3K8,MYC,ODC1,PTGS2,SERPINE1,TNFSF10 | 476 (17) |
| ALB | -5.90e-01 | transporter | NA | 1.77e+00 | 1.0e-02 | ALB,CCL2,Ccl2,CDKN1A,EDN1,EDNRA,ERN1,PTGS2 | 501 (22) |
| NGF | 1.20e-01 | growth factor | NA | 1.77e+00 | 0.0e+00 | ACER2,ADGRL2,ATF3,BCL2L1,BTG2,CCL4,CD83,CDKN1A,DPYSL5,DUSP1,DUSP8,EPHA4,ERRFI1,FOS,FOSL1,FOSL2,GADD45A,GADD45G,GAL,HMOX1,IER3,IFRD1,JUNB,MMD,MMP9,MYC,MYCN,NGFR,PLAUR,PLG,PPP2R2B,SMIM3,TNFRSF12A,TP73,TRPA1,TRPV1,WNT5A,ZFP36 | 429 (17) |
| MAP2K4 | 2.40e-01 | kinase | NA | 1.77e+00 | 0.0e+00 | ATF3,BCL2L1,CDKN1A,CRP,CXCL10,ERRFI1,FOS,GADD45A,IL12B,MUC5B,PTGS2 | 406 (16) |
| carbamylcholine | NA | chemical drug | NA | 1.76e+00 | 1.0e-02 | ARG2,BTG2,CDKN1A,ECE1,FOS,GEM,TGFA | 464 (21) |
| erlotinib | NA | chemical drug | NA | 1.76e+00 | 0.0e+00 | BCL2L1,CCL2,CD14,CXCL3,CXCL6,F3,FCER2,IL12B,IL1A,LIF,NFKBIA,PDGFB,PLAUR,SERPINE1,TGFA,TLR5,TNFRSF13C | 542 (17) |
| PG3-Oc | NA | chemical reagent | NA | 1.76e+00 | 0.0e+00 | ACER2,ATF3,ATF4,CDKN1A,EPHA2,HSPA4L | NA |
| GC-GCR dimer | NA | complex | NA | 1.75e+00 | 0.0e+00 | CD163,DUSP1,IL1R2,NFKBIA,PCK1,PDK4 | NA |
| levodopa | NA | chemical - endogenous mammalian | NA | 1.75e+00 | 0.0e+00 | ADORA2A,ARG2,ARHGAP4,BCL2L1,CA12,CAMK1G,CIB2,CLDN5,CRY2,CRYM,DLGAP1,DLK1,DOC2B,DUSP1,ECE1,FAM81A,FKBP5,FOS,FOSL1,FRAT2,FTL,GABARAPL1,GADD45B,GAS7,IER3,JUNB,KCNA5,KCNA6,KCNK1,LAG3,LAT2,LRRTM3,NEDD4L,NOCT,NPC2,NTRK3,Oasl2,PER1,PGM2L1,PKIA,PPP1R13B,PPP1R1B,PPP3R1,PPP4R4,RASGRP1,REM2,RERG,RILPL1,SBK1,SCN4B,SEZ6,SLC24A2,SLC38A2,SMPD3,SPAG6,SRPK3,TNFRSF19,TRERF1,TRPC3,ZEB2 | 430 (18) |
| lactacystin | NA | chemical - protease inhibitor | NA | 1.74e+00 | 0.0e+00 | APOB,ATF3,ATP1A1,CCL2,Ccl2,CD69,CDKN1A,CXCR4,DUSP1,EBNA1BP2,FOSL1,FTL,GCLC,GNAI2,HMOX1,IFRD1,IL12B,IRS1,MMP9,MYCN,NCS1,NEDD9,NFKBIA,P4HA2,PTGS2,SAT1,SFTPB,THRB,TXNRD1 | 574 (21) |
| CSF2RB | -9.00e-02 | transmembrane receptor | NA | 1.74e+00 | 0.0e+00 | ADGRE1,BCL2L1,FOS,JUNB,MYC,SNAP23 | 324 (18) |
| carboplatin | NA | chemical drug | NA | 1.74e+00 | 0.0e+00 | ABCB1,ABCC2,ADORA2B,CD274,CLDN4,FGA,IER3,LCN2,LGALS3,MYC,PLA1A,PNKD,RBM3,SOX2,TIMP1,TNFRSF12A,UPP1 | 337 (11) |
| quinolinic acid | NA | chemical - endogenous mammalian | NA | 1.74e+00 | 0.0e+00 | BCL2L1,FOS,JUNB,MYC,NGFR,NRTN,NTRK3,PTGS2 | 442 (16) |
| BHLHE40 | 7.20e-01 | transcription regulator | NA | 1.74e+00 | 0.0e+00 | ADORA2B,AFF3,ATF3,ATP1B1,BCL2L1,C3AR1,CALCRL,CD14,CD274,CD69,CXCL3,EREG,FASN,GBP2,HAS1,HK2,IER3,IFITM2,IL1R2,IL2RB,IL6R,INHBA,IRAK2,KCNA3,Klrk1,LIF,LOX,LPAR1,LTB,MAFF,MERTK,NTRK3,P2RY14,P4HA1,PER1,PFKFB3,PROCR,PTGS2,PTPRC,RASGRP1,RGS16,RND3,SDC4,SELL,SLAMF6,SLC16A3,SLC28A2,SLC6A6,SOCS3,STAT1,TPBG,UPP1 | 529 (22) |
| P2RY6 | -8.00e-02 | G-protein coupled receptor | NA | 1.73e+00 | 0.0e+00 | Ccl2,CIDEA,CPT1B,PPARA,TBX21,TMEM26 | NA |
| MAC | NA | complex | NA | 1.73e+00 | 1.0e-02 | CXCL2,PTGS2,RGCC,RGS16,THBS1,ZFP36 | 496 (18) |
| hydroxypropyl-beta-cyclodextrin | NA | chemical drug | NA | 1.73e+00 | 1.0e-02 | ALB,BTLA,CCL2,CCR6,CD19,CD5L,CD79A,CX3CR1,CXCL6,IL1A,LAMA5,LPIN1,NPC2 | 313 (10) |
| glucocorticoid | NA | chemical drug | NA | 1.73e+00 | 0.0e+00 | BMP6,CCL2,CD163,CD40LG,CD69,CD79B,CDKN1A,CEBPD,CLDN5,CR2,CXCL2,CXCR4,DUSP1,EDN1,FASN,FCER2,GABRP,GLUL,GZMB,HLA-DOB,HMOX1,IL12B,IL1A,IL1R2,IL6R,JAK3,KCNJ11,KRT17,LAG3,LAT2,LPIN1,LTA,MAOA,MMP9,Mt1,MYC,NFKBIA,ODC1,PCK1,PER1,PLAT,PPARA,PTGS2,SELE,SERPINE1,SFTPB,SOCS3,TLR10,TNFRSF18,TRH,TXNIP,ZBTB16 | 547 (19) |
| ACKR2 | 5.90e-01 | G-protein coupled receptor | NA | 1.73e+00 | 0.0e+00 | Ccl2,CXCL10,IFI44,IL1A,ISG15,OAS2,Oasl2,RSAD2,STAT1,USP18 | 325 (15) |
| aspirin | NA | chemical drug | NA | 1.73e+00 | 0.0e+00 | AR,BCL2L1,BMP6,CALCRL,CCL2,Ccl2,CCL4,CDKN1A,CRP,CXCL10,CXCR4,DACH1,F2RL1,GLI1,IER3,IL12B,IL1A,KDR,MCAM,MMP9,NGFR,PON1,PPARA,PTGER3,PTGS2,SELL,SELP,SOX7,THBS1,TNFSF10,TRPC3,XCL1 | 472 (18) |
| ISL1 | 5.00e-01 | transcription regulator | NA | 1.72e+00 | 4.0e-02 | ACTC1,ADGRG2,GAL,IAPP,IL1A,KCNJ11,LILRB3,NTRK3,RBM24,TRPV1 | NA |
| Foxp1 | -1.70e-01 | transcription regulator | NA | 1.72e+00 | 0.0e+00 | BCL2L1,KCNT1,MTCL1,MYCN,PCK1,PIK3IP1,SPHKAP | 394 (13) |
| Collagen type II | NA | complex | NA | 1.72e+00 | 0.0e+00 | BMP2,BMP6,BMP7,Ccl2,CCL24,CRP,CX3CR1,CXCL2,CXCL3,IL1A,MAP3K8,TNFSF10 | 533 (21) |
| butylated hydroxyanisol | NA | chemical toxicant | NA | 1.72e+00 | 1.0e-02 | FOS,GCLC,NR0B2,Slco1a1,SOX2,TGFA | NA |
| CFI-402257 | NA | chemical drug | NA | 1.71e+00 | 0.0e+00 | CCL2,CXCL2,CXCL3,EREG,GEM,IL1A,INHBA,PLAT,PLAUR | 408 (14) |
| gemfibrozil | NA | chemical drug | NA | 1.71e+00 | 2.0e-02 | BMP7,CPT1A,CRP,GADD45A,MYC,NFKBIA,POR,SERPINE1,SOCS3 | NA |
| PALMD | -3.00e-02 | other | NA | 1.71e+00 | 0.0e+00 | BMP2,CCL2,CXCL2,HK2,MAP3K8,PFKFB3 | NA |
| BAX | 1.60e-01 | transporter | NA | 1.71e+00 | 3.0e-02 | CDKN1A,CTSH,CXCL10,EDEM1,IFITM2,MMP9,TIMP1 | NA |
| CTF1 | -6.00e-02 | cytokine | NA | 1.71e+00 | 0.0e+00 | CEBPD,CRP,FASN,FOS,IL4R,IRS1,JUNB,PNPLA2,SOCS3,TIMP1 | 377 (18) |
| RETNLB | NA | other | NA | 1.71e+00 | 0.0e+00 | CCL2,Ccl2,IL4R,IRS1,KLF15,MAP3K6,MYC,MYCT1,PLA1A,SOCS2,STK17B,TIMP1,TINAGL1,WNT5A | 476 (15) |
| miR-182-5p (and other miRNAs w/seed UUGGCAA) | NA | mature microRNA | NA | 1.71e+00 | 1.0e-02 | CMPK2,GADD45G,IFI44L,IFIT1,ISG15,OAS2,PGF,RSAD2,STAT1 | NA |
| PRKCE | -3.00e-02 | kinase | NA | 1.70e+00 | 0.0e+00 | ABCB1,BCL2L1,CDKN1A,CDON,CRP,FOS,IL2RB,ITGA2B,JUNB,MMP9,MYC,ODC1,PTGER3,PTGS2 | 349 (15) |
| PTHLH | NA | other | NA | 1.70e+00 | 0.0e+00 | Acan,ADAMTS1,AR,BCL2L1,Ccl2,CDKN1A,COL2A1,FOS,FOSL2,MMP9,PTGS2,SERPINE1,SMPD3,TGM1 | 460 (20) |
| A-Fos | NA | chemical reagent | NA | 1.70e+00 | 0.0e+00 | CCL4,IER3,MYC,ODC1,TBX21,TNFRSF18 | NA |
| EPHX2 | -5.00e-02 | enzyme | NA | 1.70e+00 | 0.0e+00 | BMP2,CCL2,Ccl2,CXCL6,DLL1,SELE | 478 (22) |
| CBX7 | 6.00e-02 | other | NA | 1.70e+00 | 0.0e+00 | ANKRD1,BMP2,CBX2,KYNU,MMP9,SOX2 | NA |
| ZBTB17 | 2.20e-01 | transcription regulator | NA | 1.70e+00 | 0.0e+00 | AURKB,BHLHE40,CDKN1A,IER3,LRRN3,NGFR,NOCT,ODC1,OSMR,PBK,ZFP36 | 452 (14) |
| W7 | NA | chemical reagent | NA | 1.70e+00 | 1.0e-02 | CCL2,CD14,CD83,COL2A1,FOS | 390 (16) |
| GCG | NA | other | NA | 1.69e+00 | 0.0e+00 | BCL2L1,BTG2,CBS/LOC102724560,CCL2,CPT1A,FASN,FOS,FOSL2,Gsta1,IAPP,LPIN1,NFYA,ODC1,PCK1,PDHA1,Plekha6,PPARGC1B,PPP1R1B,PPP1R3C,PTPRN,RBM14,Sik1,TNFAIP6 | 493 (20) |
| dinoprost | NA | chemical - endogenous mammalian | NA | 1.68e+00 | 0.0e+00 | Acan,ANGPTL3,ATP1A1,EDN1,FOS,FOSL2,HSD11B2,IL1A,MMP9,MYC,NFIL3,PLCD1,POR,PTGS2,PTX3,SCN1B,TGFA,THBS1,TIMP3 | 527 (24) |
| MYOD1 | NA | transcription regulator | NA | 1.68e+00 | 0.0e+00 | ACTC1,ADORA1,ANKRD1,ASB2,BCL2L1,CCL2,CDH15,CDKN1A,CDO1,CYP2S1,DUSP1,DYSF,ENO3,FNDC5,FOSL1,GADD45A,GADD45G,HSPA4L,IRX1,ITGA7,JUNB,LIF,MYBPH,Nes,PBK,PRIMA1,SBK1,SCN4A,SIX1,STAT1,TGFBR3,UBA7 | 476 (19) |
| CRP | -6.10e-01 | other | NA | 1.68e+00 | 1.0e-02 | CCL2,Ccl2,IL6R,PRKCB,PRKCG,SELL,SERPINE1,TNFSF10 | NA |
| phencyclidine | NA | chemical drug | NA | 1.67e+00 | 0.0e+00 | BCL2L1,CDON,CREM,FOS,GAL,HDC,IER3 | 435 (20) |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | NA | chemical toxicant | NA | 1.67e+00 | 0.0e+00 | ADGRE1,Ccl2,EGR3,FKBP5,FOS,FUBP1,HAPLN2,HMOX1,IL1A,LIF,PTGS2,PTPRC,ZBTB16 | 332 (18) |
| Pro-inflammatory Cytokine | NA | group | NA | 1.67e+00 | 0.0e+00 | ABCC2,F3,GCLC,GLUL,HMOX1,LCN2,MMP9,SDC4,SELE,SELP,SOCS3,TIMP1 | 414 (16) |
| NFKBIA | 1.12e+00 | transcription regulator | NA | 1.67e+00 | 0.0e+00 | ADAMTS5,ADGRE5,ANKRD1,AURKB,AZGP1,BCL11A,BCL2A1,BCL2L1,BMP2,BTG2,CCL2,Ccl2,CCR3,CD69,CDKN1A,CEBPD,COL2A1,CREB3L3,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,CYP7B1,EREG,F3,FGFR4,FOS,GADD45A,GADD45B,GADD45G,GBP2,GNRH1,GRK5,GZMB,HAS1,HK2,HMOX1,IER3,IL1A,IL33,ISG15,JUNB,LAMA5,LCN2,LIF,MGP,MMP9,Mt1,MYC,NFKBIA,NOCT,PDHA1,PLAT,PTGS2,PTX3,RGS16,S100A8,SAT1,SDC4,SELE,SOAT1,SOCS3,SPOCK1,TCEAL9,TIMP1,TIMP3,TNFSF10 | 495 (17) |
| TANK | 1.60e-01 | other | NA | 1.67e+00 | 0.0e+00 | CXCL2,CXCL3,IFIT1,IL12B,IL1A,LTA,PLA1A,PTGS2,RGCC,ZC3H12A | 427 (16) |
| TLR7/8 | NA | group | NA | 1.67e+00 | 0.0e+00 | BCL2A1,CCL2,EDN1,EREG,GEM,MAP3K8,NFKBIA,PLAUR,PTGS2,TNFAIP6 | 491 (15) |
| paclitaxel | NA | chemical drug | NA | 1.67e+00 | 0.0e+00 | ABCB1,ADGRE1,ADORA2B,AR,ATF3,ATF4,BCL2L1,BHLHE40,BTG2,CCL2,CD274,CDKN1A,CRP,CRY2,CXCL10,CXCL2,CXCL6,ELL,EPHA2,EREG,FMO3,FOSL1,G0S2,GADD45B,GFPT2,GRINA,IER3,ITPKC,LGALS3,MMP9,MYC,NCS1,NFKBIA,OSMR,PLAUR,PNKD,PRSS22,PTGS2,RBM3,SAT1,SCN1B,SHB,SOX2,TFPI2,TGFA,THBS1,TP73 | 504 (15) |
| Ap1 | NA | complex | NA | 1.67e+00 | 0.0e+00 | ATF3,BCL2A1,BCL2L1,C3AR1,CCL2,CCL4,CD40LG,EDN1,F2RL1,F3,FOS,FOSL1,GZMB,HMOX1,IFRD1,IL12B,IL1A,IL33,MMP9,MYC,PCK1,PLAUR,Ppp1r15a,PTGS2,SELE,SERPINE1,SOCS3,TGFA,TIMP1,TNFRSF8 | 436 (16) |
| indomethacin | NA | chemical drug | NA | 1.66e+00 | 0.0e+00 | ADAMTS1,ADAMTS5,ARG2,BCL2L1,BTG2,CCL2,Ccl2,CD14,CD40LG,CDKN1A,CLDN4,CPT1A,Ctla2a,CXCR4,DYNLL1,FASN,FGA,FOS,HAS1,HMOX1,IER3,IL1A,LCN2,LGALS3,MYC,NGFR,PDE4C,PLA1A,PLAUR,PPARA,PTGS2,RBM3,RCN1,S100A8,SELL,SLC7A5,TFPI2,TIMP1,TNFRSF12A,TNFRSF21,TP73,UPP1 | 494 (16) |
| vitamin D | NA | chemical drug | NA | 1.66e+00 | 1.0e-02 | ADAMTS1,ALB,CCL2,CCR10,CDKN1A,IRF4,MGP,NFKBIA,S100A8 | NA |
| GDF2 | 5.00e-02 | growth factor | NA | 1.66e+00 | 0.0e+00 | ACTC1,ANXA3,ATP1A1,CDH6,CXCR4,DLK1,EDN1,FAM89A,FASN,FOS,GADD45B,LYVE1,MMP9,MYC,NFKBIA,NGFR,NRP1,SELE,SLC6A6,SLC7A5,SOCS2,SOX2 | 447 (21) |
| POMC | -4.00e-02 | other | NA | 1.66e+00 | 0.0e+00 | APOB,CXCR4,DUSP1,FOS,FOSL1,FOSL2,GCLC,GZMB,HMOX1,HSD11B2,JUNB,PRF1,SELE,Sik1,TRH | 483 (21) |
| CARM1 | 9.00e-02 | transcription regulator | NA | 1.66e+00 | 0.0e+00 | ABCB11,Ccl2,CDKN1A,CXCL10,CXCL3,DDIT4,EGR3,FOS,FTL,GADD45A,GCLC,MYC,PCK1 | 495 (25) |
| TBK1 | 1.90e-01 | kinase | NA | 1.66e+00 | 0.0e+00 | BCL2L1,CCL4,CDKN1A,CMPK2,CXCL10,CXCL2,CXCL3,EDN1,H2-T24,HDC,IFI44,IFIT1,IL12B,IL1A,INHBA,ISG15,Mx2,OAS2,Oasl2,PLA1A,PTGS2,RGCC,RILPL1,RSAD2,SELE,USP18,ZC3H12A | 261 (19) |
| D-glucose | NA | chemical - endogenous mammalian | NA | 1.66e+00 | 0.0e+00 | ABCB1,Acan,ADCY5,ANXA3,APOB,AQP1,ATF3,ATF4,ATP2B3,ATP2B4,BCL2L1,BMP2,BVES,CBS/LOC102724560,CCL2,Ccl2,CDKN1A,COL2A1,CPT1B,CREM,CTSV,CXCL2,CXCR4,DDIT4,DUSP1,DYNLL1,EDN1,EFHD1,FASN,FOS,GABARAPL1,GLUL,H6PD,HK2,HMOX1,HNF4A,IAPP,INHBA,IRS1,JUNB,KCNF1,KCNMB1,KDR,MAP2K6,MCAM,MMP9,Mt1,MYC,NEXN,ODC1,OGT,PBK,PCK1,PFKFB3,PLAUR,PNPLA3,PPARA,PPP2R2B,PRKCB,PTGS2,PTPRN,S100A8,SELE,SELP,SERPINE1,SIX1,SLC16A4,SLC25A10,SLC30A3,SLC5A1,SLC7A1,SPHK1,TGFA,THBS1,TIMP1,TRIM63,TXNIP,TXNRD1 | 577 (23) |
| LIF | 7.10e-01 | cytokine | NA | 1.64e+00 | 0.0e+00 | BCL2L1,BMP2,BMP7,Ccl2,CDKN1A,CEBPD,CRP,CXCL10,CXCL2,EREG,FOS,GAL,GLUL,HK2,JUNB,KDR,MYC,Nes,PTGS2,SNAP23,SOCS2,SOCS3,SOX2,TIMP1,WNT5A | 411 (18) |
| FOXL2 | NA | transcription regulator | NA | 1.64e+00 | 0.0e+00 | ATF3,BCL2A1,BMP2,CXCL2,CXCL3,CXCL6,CYP26B1,FOS,HMCN1,IER3,INHBA,LIF,MAFF,NR5A2,OSR2,PTGS2 | 288 (10) |
| HTT | 0.00e+00 | transcription regulator | NA | 1.64e+00 | 0.0e+00 | ADAMTS4,ADAMTS5,ADCY5,ADORA2A,AQP1,ATF3,ATP1A1,ATP2B3,BAIAP2,BCL11B,BHLHE40,BMP3,CA12,CA4,CCR6,CDKN1A,CPNE5,CREB1,DIO2,DLL1,ENO3,FASN,FOS,FOSL1,GADD45G,GAS7,GCLC,GLUL,GNRH1,GRIN2D,GRK5,HAPLN3,HPCAL1,HUNK,IPMK,JUNB,KCNJ12,KCNJ4,KCNK2,LOX,MCAM,MGP,Mt1,NCS1,NFIL3,NGFR,PCTP,PDE10A,PER1,PLAUR,POR,PPARA,PPARGC1B,PPP1R1B,PRKCB,PRKCG,RAB17,RBP4,RGS16,SCN4B,SERPINH1,SESN1,SEZ6,SFPQ,Sik1,SOCS2,TBX6,TESC,THRB,TIMP3,TRH,UBE2G2,VIPR2 | 552 (23) |
| cyclic AMP | NA | chemical - endogenous mammalian | NA | 1.64e+00 | 0.0e+00 | AFAP1L2,ARG2,BMP2,CCL2,CDKN1A,CEBPD,CREB1,CREM,CRYM,F3,FOS,FOSL2,GTF3A,IL33,INHBA,JUNB,KDR,MMP9,MYC,ODC1,PCK1,PER1,PPP1R1B,PTGS2,RAPGEF3,RBP4,SERPINE1,SOCS3,STAT1,TGFA,TIMP1,TNFSF10,TRH,TXNIP | 480 (20) |
| HSPD1 | -3.10e-01 | enzyme | NA | 1.63e+00 | 0.0e+00 | Ccl2,CXCL2,CXCL3,IL12B,SELE,SOCS3,TBX21 | 405 (17) |
| FOS | 1.01e+00 | transcription regulator | NA | 1.63e+00 | 0.0e+00 | ABCB1,AQP3,ATF3,BCAR3,C3AR1,CCL2,CD14,CDON,CTSH,CTSV,CXCL10,CXCL3,DIO2,EDN1,EREG,F3,FASN,FGA,FOS,FOSL1,FOXC1,HAS1,HK2,HMOX1,IL12B,IL1A,JUNB,KLHL41,Krt2,LGALS3,LOX,MAOA,MMP8,MMP9,MYC,NFIL3,NR5A2,NUPR1,ODC1,PKN1,PLAT,PLAUR,Pmaip1,PTGS2,PTPRN,PTPRO,RAPGEF3,S100A8,SELENBP1,SERPINE1,SNAP23,SOCS3,SPHK1,SYT1,TIMP1,TNFRSF18,WNT11,WNT5A,WNT7A,XDH | 480 (17) |
| cytochalasin D | NA | chemical toxicant | NA | 1.62e+00 | 1.0e-02 | Acan,CCL2,COL2A1,FOS,MMP16,MMP9,PTGS2,SARM1 | 403 (20) |
| F2R | 2.30e-01 | G-protein coupled receptor | NA | 1.62e+00 | 0.0e+00 | CCL2,Ccl2,CXCL3,DUSP1,ECE1,EGR3,F3,FOS,HMOX1,KDR,MCAM,MMP9,MYOCD,PLAT,PLAUR,PTGS2,RGS18,SELE,SELP,TFPI2,THBS1,TRPC3 | 381 (17) |
| TXN | 2.20e-01 | enzyme | NA | 1.62e+00 | 0.0e+00 | CDKN1A,CPT1B,FOS,HMOX1,IL1A,MMP9,MS4A1,NFKBIA,SELL | 432 (15) |
| NKX2-1 | -3.20e-01 | transcription regulator | NA | 1.61e+00 | 0.0e+00 | AGR2,AQP1,BCL2A1,CA4,CD14,CHRNA7,DIO2,ENC1,FGFR4,GNRH1,IER3,LCK,LCN2,MLC1,MYBPH,Nes,PCDHA4,PGLYRP1,PON1,SEC14L2,SERPINE1,SFTPB,SOX2,THBS1,WNT11,ZNF519 | NA |
| okadaic acid | NA | chemical toxicant | NA | 1.61e+00 | 0.0e+00 | AR,BCL2L1,CXCL2,CYP46A1,FOS,FOSL2,GNAI2,HNF4A,IL1A,IL21R,IRS1,JUNB,MAP3K8,MMP9,MYC,ODC1,PTGS2 | 434 (19) |
| SREBF1 | 1.10e-01 | transcription regulator | NA | 1.61e+00 | 0.0e+00 | ADH1C,AR,BCL2L1,BHLHE40,Bhlhe41,CAMK1D,CAP2,CCL17,CD14,CDKN1A,CEBPD,CIDEA,CXCL10,CYP7B1,DBNDD1,DLK1,FABP3,FASN,HK2,HMOX1,HNF4A,IAPP,IL1A,IL1R2,KCNA2,KCNJ11,LGALS3,LPIN1,NFIL3,NR0B2,NUPR1,P4HA2,PCK1,PNPLA3,PTGS2,SERPINE1,SORBS3,TRIM63 | 515 (21) |
| EHMT1 | 1.30e-01 | transcription regulator | NA | 1.60e+00 | 0.0e+00 | ATP1A1,CDKN1A,CEBPD,EDN3,FGL1,GRINA,HSD11B2,LCN2,POR,PPL,RGCC,SAT1,SELENBP1,SLC7A7,SYBU,SYCE1 | NA |
| GRIN3A | -1.20e-01 | ion channel | NA | 1.60e+00 | 0.0e+00 | BMP3,CAMK1D,CNTN3,CNTNAP1,CPNE5,ESRRG,IFRD1,LGI1,LURAP1L,Mt1,PTGS2,RNF152,TLL1,TRIM14 | NA |
| lipopolysaccharide | NA | chemical drug | NA | 1.60e+00 | 0.0e+00 | ABCB1,ABCB11,ABCC2,Acot1,ACTC1,ADAMTS1,ADAMTS4,ADAMTS5,ADGRE1,ADORA1,ADORA2A,ADORA2B,AFF3,ALB,ANGPTL3,ANKRD1,ANXA3,APCS,APOB,AQP1,AQP3,AR,ARG2,ARL15,ARL4A,ARRDC3,ARVCF,ATF3,ATF4,ATP1A1,AURKB,AZGP1,BANK1,BCL11B,BCL2A1,BCL2L1,Bhlhe41,BMP2,BTLA,C3AR1,CALCRL,CBLB,CCDC170,CCL17,CCL19,CCL2,Ccl2,CCL24,CCL4,CCR3,CCR6,CCR9,CD14,CD163,CD180,CD19,CD22,CD274,CD28,CD37,CD40LG,CD69,CD79B,CD83,CD8A,CDC42EP4,CDCA7,CDKN1A,CEBPD,CEMIP,CHST3,CHST7,CIITA,CLDN5,CLEC10A,CMPK2,CPB2,CPT1A,CPT1B,CR2,CREB3L3,CRELD2,CREM,CRP,CSF3R,CTSV,CUBN,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,CYP7B1,DDIT4,DIO2,DLL1,DNASE1L3,DUSP1,DUSP8,Eda,EDEM1,EDN1,EGR3,ELK3,EREG,ERN1,EZH2,F2RL1,F3,FABP3,FASN,FCER2,FGA,FOS,FOSL1,G0S2,GADD45A,GADD45B,GADD45G,GBP2,GBP4,GBP5,GCLC,GEM,GFPT2,GHRHR,GIMAP7,GJB2,GLP2R,GNRH1,GPR3,GZMA,GZMB,H2-T24,HAS1,HDC,HIPK2,HK2,HLA-DOB,HMOX1,HNF4A,HSD11B2,HSH2D,HSPA4L,IER3,IFI44,IFI44L,IFIT1,IFITM2,IFRD1,Igtp,IKBKE,IKZF3,IL12B,IL1A,IL1R2,IL21R,IL24,IL2RB,IL33,IL4R,IL6R,INHBA,IRAK2,IRF4,Irgm1,ISG15,ITGB7,ITIH4,ITPKC,JAK3,JUNB,KCNA3,KCNK1,KCNK5,KCNMB4,KDR,Klrk1,KYNU,LCK,LCN2,LGALS3,LIF,LMO4,LOX,LPAR1,LPIN1,LPIN2,LTA,LTB,LY86,LYVE1,MAFF,MAOA,MAP1LC3B,MAP3K6,MAP3K8,Meis1,MERTK,MKNK2,MMP8,MMP9,MS4A1,Mt1,MUC5B,MX1,Mx2,MYC,MYCN,NECTIN4,NFIL3,NFKBIA,NGFR,NOCT,NR0B2,NR5A2,NRP1,NRTN,NUPR1,OAS2,Oasl2,ODC1,OGT,OSBPL3,OSMR,P2RY14,P4HA1,PAX5,PBK,PDE10A,PDGFB,PDK4,PFKFB3,PGLYRP1,PLAT,PLAUR,PLG,PNPLA1,Podxl,POU2AF1,POU2F2,PPARA,PPARGC1B,PPP1R13B,PRKCB,PROCR,PTGS2,PTPRC,PTPRCAP,PTPRO,PTX3,RAB20,RAB37,RAMP3,RAPGEF3,RASGRP1,RGCC,RGS16,RND3,RNF213,RSAD2,S100A8,SARM1,SAT1,SDC4,SELE,SELL,SELP,SERPINB1,SERPINC1,SERPINE1,SERPINF2,SERPINH1,SESN1,SFTPB,SGPP2,Siglech,Sik1,SLC10A1,SLC11A1,SLC16A3,SLC28A1,SLC28A2,SLC38A2,SLC39A10,SLC5A1,SLC6A6,SLC7A5,Slco1a1,SNAP23,SNCAIP,SOCS2,SOCS3,SPHK1,SSBP3,STAP1,STAT1,TBX21,TELO2,TFPI2,TGFA,TGFBR3,THBS1,THRB,TIMP1,TIMP3,TLR10,TLR5,TNFAIP6,TNFRSF19,TNFSF10,TNFSF18,TNFSF8,Tnfsf9,TP53BP2,TPBG,TREM3,TREML2,TRIB1,TRIL,TRIM63,TXNIP,UPP1,USP18,VIPR2,WNT5A,XCL1,XCR1,XDH,ZBP1,ZBTB16,ZC3H12A,ZFP36 | 600 (17) |
| LCN2 | 7.90e-01 | transporter | NA | 1.60e+00 | 0.0e+00 | BMP2,CCL17,Ccl2,CCL4,CCR10,CXCL10,CXCL2,CXCL3,CXCL6,FASN,HMOX1,IL1A,PNPLA2,RBP4,TINAGL1,TRIM63 | 421 (18) |
| fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether | NA | chemical toxicant | NA | 1.60e+00 | 0.0e+00 | ATF3,Ccl2,CDO1,CXCL10,FGA,HMOX1,LGALS3,ODC1,Slco1a1,TIMP1,TNFRSF12A | NA |
| SCARB1 | -1.60e-01 | transporter | NA | 1.60e+00 | 0.0e+00 | APOB,CCL2,CXCL2,DDIT4,F3,FABP3,FASN,LTA,PTGS2,SELE,SELP,SESN1,TRIM63 | 352 (16) |
| SMAD2 | -2.40e-01 | transcription regulator | NA | 1.60e+00 | 0.0e+00 | Acan,CDKN1A,COL2A1,CRISPLD2,FSTL3,GADD45B,GZMB,HMOX1,IL6R,IRX1,MMP9,PCLO,PDGFB,PTX3,SELE,SERPINE1,SFTPB,SOX2,SPHK1,THBS1,TIMP3 | 503 (17) |
| PTX3 | 1.20e+00 | other | NA | 1.60e+00 | 0.0e+00 | CCL2,Ccl2,CCL4,CX3CR1,CXCL2,EGR3,F3,FOS,MMP9 | 356 (15) |
| rituximab | NA | biologic drug | NA | 1.59e+00 | 0.0e+00 | ADORA2A,BCL2A1,BCL2L1,CCL4,CD19,CD22,CDKN1A,MS4A1 | 413 (18) |
| ciglitazone | NA | chemical drug | NA | 1.59e+00 | 0.0e+00 | ACTC1,AQP3,BCL2L1,CCL2,Ccl2,CD40LG,CDKN1A,CIITA,GAL,IAPP,IFITM2,IL12B,LCN2,MMP9,Nes,NFKBIA,NR5A2,Podxl,PTGS2,SELE,SERPINE1,TGM1,TNFSF10 | 318 (15) |
| nickel chloride | NA | chemical toxicant | NA | 1.59e+00 | 0.0e+00 | ATF4,CCL2,DDIT4,GCLC,HMOX1,MAFF,MAP2K6,P4HA1,PTGS2,TXNRD1 | 356 (14) |
| INHBA | -8.20e-01 | growth factor | NA | 1.58e+00 | 0.0e+00 | ANKRD1,BCL2L1,BMP2,CCL17,CCL2,CD28,CDKN1A,CLDN11,CXCR4,DACH1,ERBB3,EREG,FIGN,FSTL3,GULP1,INHBA,IRX1,JUNB,LOX,MGP,PGM2L1,PSMD9,RGS16,S100A8,SERPINE1,SOX2,TIMP1 | 410 (18) |
| NGLY1 | 4.00e-02 | enzyme | NA | 1.58e+00 | 1.0e-02 | CXCL10,IFI44,IFI44L,IFIT1,RSAD2,USP18 | NA |
| GAST | -5.00e-02 | other | NA | 1.58e+00 | 0.0e+00 | ABCC2,ATF4,CREM,FOS,HDC,MMP9,NFKBIA,ODC1,POR,PTGS2,SELP,TGFA | 456 (20) |
| EPHB1 | -1.50e-01 | kinase | NA | 1.57e+00 | 0.0e+00 | Ccl2,FOS,JUNB,PCK1,PTGS2,SERPINE1 | 443 (17) |
| PPRC1 | 1.40e-01 | transcription regulator | NA | 1.57e+00 | 0.0e+00 | ATF4,BMP6,DDIT4,ERRFI1,FBXL13,HK2,IL1A,LCN2,MYCT1,PTGS2,RND3 | NA |
| progesterone | NA | chemical - endogenous mammalian | NA | 1.57e+00 | 0.0e+00 | ABCB1,Acot1,ADAMTS1,ADCYAP1R1,AQP1,AR,ARID5A,ARL4A,ATF3,ATP1B1,BCL2L1,BHLHE40,BMP2,CA12,CAPRIN2,CCL2,CCR3,CDKN1A,CEBPD,CKMT1A/CKMT1B,CLCA1,CLDN4,CLDN5,CSF3R,CTSV,CXCL10,CXCL6,CXCR4,EDN3,EDNRA,ENC1,ERBB3,ERRFI1,F2RL1,F3,FKBP5,FOS,FOSL1,FOXC1,FRAT2,GABARAPL1,GAL,GJB2,GNRH1,Gpr165,GRINA,HDC,HSD11B2,HSD17B2,HUNK,IL12B,IL1A,IL33,IL6R,INHBA,IRS1,KCNG1,KCNK1,KDR,KRT7,LCN2,LGALS3,LIF,LPIN1,MAOA,Meis1,MMP9,MX1,MYC,MYCN,NEDD9,NFIL3,NFKBIA,NRP1,NUPR1,OSGIN1,PCK1,PDHA1,PFKFB3,PLCL1,PNKD,PPP1R1B,PRSS35,PTGER1,PTGER3,PTGS2,PTX3,RBP4,SFN,SIX4,SPHK1,SPSB1,STAT1,TBC1D8,TGFBR3,TGM1,THBS1,TIMP1,TIMP3,TNFRSF21,TNFSF10,TRPV1,Wdr86,XDH | 571 (20) |
| amphetamine | NA | chemical drug | NA | 1.56e+00 | 0.0e+00 | ADORA2B,ATF3,ATF4,BCL2L1,CREB1,F3,FOS,FOSL1,FOSL2,INHBA,JUNB,MAOB,SELL,SLC6A2 | 509 (23) |
| Ngf | NA | group | NA | 1.56e+00 | 0.0e+00 | CCNA1,CDKN1A,CIDEA,DIO2,DUSP1,FOS,NGFR,ODC1,PLAUR,SERPINE1,TRPV1 | 494 (18) |
| CCL2 | -9.80e-01 | cytokine | NA | 1.56e+00 | 0.0e+00 | BCL2L1,BPIFB1,CCL2,Ccl2,CD40LG,CEBPD,CXCL10,CXCL3,F3,FOS,GJB1,HDC,IAPP,IL12B,IL1A,INHBA,LCN2,MMP9,MUC5B,PTGS2,SERPINE1,SLC11A1,SOX2,STAT1,TIMP1,ZC3H12A | 467 (15) |
| propofol | NA | chemical drug | NA | 1.56e+00 | 0.0e+00 | BCL2L1,CCL2,CD14,FOS,GJB1,HMOX1,MMP9,THBS1,ZFP36 | 459 (20) |
| allopurinol | NA | chemical drug | NA | 1.55e+00 | 0.0e+00 | ABCC2,ADAMTS1,CD14,CD69,CLDN4,Ctla2a,CXCL10,F3,FGA,HMOX1,IER3,LCN2,LGALS3,MYC,PLA1A,PTGS2,RBM3,RCN1,TIMP1,TNFRSF12A,TXNIP,UPP1 | 476 (18) |
| pidnarulex | NA | chemical drug | NA | 1.55e+00 | 1.0e-02 | BTG2,CDKN1A,CEMIP,FAT2,GADD45A,IER3,INHBA,MAP1LC3B,RYR2,SESN1,SESN2 | 337 (7) |
| PI3K (complex) | NA | complex | NA | 1.55e+00 | 0.0e+00 | ATF3,ATF4,BCL2A1,BCL2L1,CCL2,Ccl2,CCL4,CD274,CD40LG,CD79B,CDKN1A,CREB1,CXCL10,CXCR4,DDIT4,DUSP1,FOS,FOSL1,GCLC,GLI1,HAS1,HAS3,HK2,HMOX1,IFIT1,IL12B,IL33,KDR,LCN2,MCAM,MMP9,MYC,NFKBIA,PPP1R1B,PTGS2,Rcan1,RND3,SELL,SERPINE1,SLC26A3,SOAT1,SOCS3,THBS1,TNFSF10,TXNIP | 488 (15) |
| lithocholic acid | NA | chemical - endogenous mammalian | NA | 1.55e+00 | 2.0e-02 | ABCB11,GCLC,IL12B,PLAUR,SLC10A1,SLC22A7,Slco1a1 | NA |
| NOD2 | 2.70e-01 | other | NA | 1.54e+00 | 0.0e+00 | BCL2A1,BMP2,CCL2,CXCL10,CXCL2,CXCL3,IER3,IL12B,IL1A,LMO4,MAP3K8,NFKBIA,RASGRP1,SOCS3 | 291 (13) |
| HNRNPK | 1.00e-02 | other | NA | 1.53e+00 | 0.0e+00 | AR,CDKN1A,IGSF10,LPIN1,MYC,PTGS2,SLC47A1,SOX2,SPN,TCN2,ZNF519 | 420 (16) |
| C5 | NA | cytokine | NA | 1.53e+00 | 0.0e+00 | APCS,ATF3,C3AR1,CCL2,Ccl2,CCL4,CRP,CXCL10,CXCL2,CXCL3,ERN1,F3,IL12B,IL1A,MMP9,NFKBIA,PLAT,SELE,SERPINE1,ZFP36 | 447 (14) |
| sodium orthovanadate | NA | chemical reagent | NA | 1.53e+00 | 0.0e+00 | BCL2L1,CCL2,CDKN1A,IL4R,NFKBIA,PLAUR,SERPINE1,SLC2A5 | 437 (17) |
| mir-9 | NA | microRNA | NA | 1.53e+00 | 1.0e-02 | AR,CXCR4,JAK3,RUNX1T1,ZFP36 | NA |
| PIM1 | 4.20e-01 | kinase | NA | 1.53e+00 | 0.0e+00 | ABCB1,BCL2L1,CCNA1,CDKN1A,EPHA2,ERBB3,FOSL1,MYC,SELL,TBX21,TNFRSF18 | 493 (26) |
| vinblastine | NA | chemical drug | NA | 1.53e+00 | 1.0e-02 | ABCB1,AR,CDKN1A,FOS,MYC,PTGS2 | NA |
| H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one | NA | chemical reagent | NA | 1.53e+00 | 0.0e+00 | CD83,CD8A,CDKN1A,FOS,HMOX1,IL12B,MMP9,PLAUR,PTGS2 | 336 (16) |
| PD 123319 | NA | chemical drug | NA | 1.53e+00 | 0.0e+00 | Ccl2,CX3CR1,FASN,FOSL2,KDR,PTGS2,SERPINE1,TIMP1,WNT11 | 521 (21) |
| SQSTM1 | 3.40e-01 | transcription regulator | NA | 1.52e+00 | 0.0e+00 | ARID5A,CXCL10,CXCL2,EDN1,GCLC,HMOX1,IL12B,ISG15,LTA,MAP1LC3B,NFKBIA,PLAT,RGCC,RILPL1,RSAD2 | 340 (14) |
| JAG1 | 2.00e-01 | growth factor | NA | 1.52e+00 | 0.0e+00 | CDKN1A,CLDN4,DUSP1,DUSP8,ERBB3,GADD45A,HEYL,MAOA,MMP9,MYC,SOX2,TIMP3,TRPA1 | 432 (19) |
| MAPT | 1.30e-01 | other | NA | 1.52e+00 | 0.0e+00 | ALB,ATF3,ATP1B1,C3AR1,CCL2,Ccl2,CCL4,CD14,CD22,CD274,CD84,CDKN1A,CHRNA7,CKMT1A/CKMT1B,CRYM,CXCL10,CXCL2,ENDOU,FASN,FOS,GALNT15,GAS7,GBP2,GBP4,GBP5,GEM,HMOX1,HSPA4L,IFI44,Igtp,IL1A,IL21R,Irgm1,ISG15,LAG3,LCN2,Lrrc74b,LY86,MMP9,Mx2,Oasl2,OSMR,PCLO,Pcp4l1,PPP1R1B,PPP3R1,PTPRC,PTX3,RNF213,SERPINE1,SERPINF2,SGIP1,SLC16A3,SLC38A3,SLC43A3,TCN2,TGM1,THBS1,TIMP1,TPPP,UBC,USP18,ZBP1 | 464 (18) |
| PLCE1 | 2.00e-02 | enzyme | NA | 1.52e+00 | 0.0e+00 | CCL2,Ccl2,CXCL2,CXCL3,PTGS2 | 348 (17) |
| MAP3K8 | 8.70e-01 | kinase | NA | 1.52e+00 | 0.0e+00 | ARRDC3,Ccl2,CCL4,CEBPD,CIITA,CXCL2,CXCL3,DOK2,FOS,GFI1,IER3,IL12B,IL1A,INHBA,JUNB,MMP9,PLAT,PPARGC1B,PTGS2,RASGRF1,SBK1,SESN1,SIX1,SOCS3,STK17B,TBX21,TXNIP | 431 (19) |
| morphine | NA | chemical drug | NA | 1.52e+00 | 0.0e+00 | ABCB1,CDKN1A,CREB1,ERBB3,FOS,FOSL1,FOSL2,FZD10,GNAI2,IL12B,JUNB,KCNA5,MMP9,NTRK3,PLAT,PTGS2,SOX2,THBS1,WNT7A | 422 (19) |
| ATF6 | -5.00e-02 | transcription regulator | NA | 1.52e+00 | 2.0e-02 | CPT1A,FOS,MAP1LC3B,MYOCD,NR0B2,PCK1,PLAT,PPARA | NA |
| homocysteine | NA | chemical - endogenous mammalian | NA | 1.51e+00 | 0.0e+00 | ATF3,ATF4,BCL2L1,CCL2,Ccl2,CDKN1A,CLDN5,CXCL10,F3,FASN,FOSL2,GADD45A,HMOX1,PGF,Pmaip1,PON1,PTGS2,SOCS3,TIMP1 | 465 (20) |
| NRIP1 | 7.00e-02 | transcription regulator | NA | 1.51e+00 | 0.0e+00 | CDKN1A,CIDEA,CPT1B,FABP3,FASN,MMD,OTUB2,PDK4,PTGS2,PTX3,TNFAIP6 | 620 (22) |
| telmisartan | NA | chemical drug | NA | 1.51e+00 | 1.0e-02 | CCL2,CD163,CLEC10A,CPT1A,MMP9,PPARA,PTGS2,TRPC3 | NA |
| Il3 | NA | cytokine | NA | 1.51e+00 | 0.0e+00 | ADGRE1,BCL2L1,BHLHE40,CD14,CDKN1A,COL2A1,CSF3R,FOS,LCN2,MYC,NFIL3,SNAP23 | 362 (18) |
| CRNDE | NA | other | NA | 1.50e+00 | 0.0e+00 | BCL2L1,CDKN1A,DUSP8,EPHA2,GADD45B,MAP3K8,PGF | 178 (7) |
| RUNX2 | -5.60e-01 | transcription regulator | NA | 1.50e+00 | 0.0e+00 | ABCB1,ADAMTS5,BMP2,CDKN1A,CEBPD,CIITA,EDN1,GADD45B,GALNT3,GFI1,LGALS3,NEXN,RGCC,SERPINE1,TIMP1 | 457 (21) |
| FOXO1 | 2.00e-01 | transcription regulator | NA | 1.50e+00 | 0.0e+00 | Acan,AFF3,ALB,ANXA3,AR,ATF4,BANK1,BCL2A1,Ccl2,CCL4,CD79B,CDKN1A,CEBPD,CIDEA,CLDN5,COL2A1,CPT1A,CPT1B,CTSV,CXCL10,CYP7B1,DDIT4,DIO2,EDN1,EFHD1,FASN,FOS,FOXC1,GABARAPL1,GADD45A,GADD45B,GFPT2,GZMA,HMOX1,IER3,IRS1,JUNB,LPIN2,MAP1LC3B,MMP9,MYC,MYCN,PAX5,PBK,PCK1,PDK4,PIK3IP1,PNPLA2,PPARGC1B,PRF1,PTPRC,Rcan1,SELL,SERPINB1,SERPINE1,SESN1,SFN,SOX2,TBX21,THBS1,TNFSF10,TRIM63,TXNIP | 481 (21) |
| Tgf beta | NA | group | NA | 1.50e+00 | 0.0e+00 | ADGRE5,ADH1C,ARNT2,ATP1B1,BCL2L1,BHLHE40,CCL2,Ccl2,CCL4,CD274,CD300LB,CD69,CD79A,CDKN1A,CIITA,CX3CR1,CXCL10,CXCL2,CXCL3,CXCR4,EDN1,F10,FOS,FSTL3,GADD45B,GCLC,GPR55,GZMB,HEYL,HIF3A,HMOX1,ID4,IL1A,JUNB,LARP6,LIF,LOX,LOXL1,MERTK,MMP9,MYC,MYCN,MYCT1,NEDD9,PDGFB,PLAT,PTGS2,RYR2,SEC14L2,SELE,SERPINE1,SERPINH1,SOCS3,SPOCK1,SSBP3,TBX21,TCF23,TGFA,THBS1,TIMP1,TIMP3,TMEM252,TNFRSF12A,TNFSF10 | 528 (17) |
| CXCL8 | NA | cytokine | NA | 1.50e+00 | 0.0e+00 | ABCB1,AR,ARG2,BCL2L1,BPIFB1,CD69,CXCL2,CXCL3,F3,GJB1,HAS1,IFRD1,LGALS3,MMP9,MUC5B,NFKBIA,PTGS2,SELL,SOX2,ZFP36 | 493 (19) |
| PIK3R1 | 1.10e-01 | kinase | NA | 1.50e+00 | 0.0e+00 | AR,ATF4,ATP1A1,BCL2L1,CCL4,CXCL10,ERBB3,ERN1,F3,FOS,HMOX1,IL12B,ISG15,MMP9,MYC,PCK1,PDHA1,PTGS2,SELP,SERPINE1,TXNIP | 501 (19) |
| benzo(a)pyrene | NA | chemical toxicant | NA | 1.49e+00 | 0.0e+00 | ABCB1,ABCC2,BLK,CDKN1A,Chn1,EREG,FASN,FOS,GCLC,GNAI2,Gsta1,HK2,HMOX1,HSPA4L,IER3,INHBA,MAFF,MAP2K6,PON1,PPP1R3C,PRKCG,PTGS2,SELENBP1,SELP,SERPINE1,THBS1,TXNRD1 | 480 (21) |
| DIO2 | -6.60e-01 | enzyme | NA | 1.49e+00 | 0.0e+00 | ASPA,ATF3,B3GNT5,CIRBP,DDIT4,DIO2,DYDC2,FOS,GADD45G,HS3ST5,INHBA,KLF15,OSR1,RBM3,REM2,SEMA7A,SLC10A6,SMIM3,ST8SIA2 | 165 (7) |
| ELF3 | 4.30e-01 | transcription regulator | NA | 1.49e+00 | 0.0e+00 | CCL2,CCL24,COL2A1,IL12B,PTGS2,ST6GALNAC5,TIMP3 | 329 (14) |
| IL17R | NA | complex | NA | 1.49e+00 | 1.0e-02 | CCL17,CCL2,CXCL3,CXCL6,S100A8 | 392 (17) |
| THBS1 | 8.40e-01 | other | NA | 1.49e+00 | 2.0e-02 | ADCYAP1R1,Ccl2,CD69,MMP9,THBS1,TIMP1 | NA |
| isobutylmethylxanthine | NA | chemical toxicant | NA | 1.49e+00 | 0.0e+00 | Ccl2,CD14,CDKN1A,CEBPD,CREB1,CREM,CXCR4,ENC1,FOS,INHBA,JUNB,LGALS12,MERTK,Mt1,MYC,PDK4,PLAT,PPARA,PTPRN,SERPINE1,STAT1,THBS1,TIMP1,TIMP3,TRH,TRPV1,ZC3H12A | 572 (24) |
| GSK3A | 3.00e-01 | kinase | NA | 1.48e+00 | 0.0e+00 | IRS1,KDR,MMP9,SELP,SERPINE1,TNFSF10 | 465 (18) |
| rifampin | NA | chemical drug | NA | 1.48e+00 | 0.0e+00 | ABCB1,ABCB11,ABCC2,ATP10B,CD14,CEP70,CXCL10,GBP2,HUNK,IFRD1,MAOB,MGP,NR0B2,SERPINB1,SLC39A10,TMPRSS4,USP18 | 272 (15) |
| entolimod | NA | biologic drug | NA | 1.47e+00 | 0.0e+00 | ATF3,BCL2A1,CCL4,CXCL10,CXCL2,CXCL3,DUSP1,HMOX1,IER3,IL1A,JUNB,NFKBIA | 225 (11) |
| USP8 | 0.00e+00 | peptidase | NA | 1.47e+00 | 0.0e+00 | Ccl2,CD274,CXCL10,CXCL2,ERBB3,IFIT1,Irgm1,ISG15,OAS2,Oasl2,STAT1 | 324 (15) |
| tributyrin | NA | chemical drug | NA | 1.47e+00 | 0.0e+00 | ATF3,AZGP1,BCL2A1,CCL2,CD274,CDKN1A,CXCL3,CXCL6,CXCR4,DUSP1,EDN1,IL24,INHBA,KRT17,PTGS2 | 400 (13) |
| KLF4 | 1.40e-01 | transcription regulator | NA | 1.47e+00 | 0.0e+00 | ACTC1,ADAMTS1,ADGRE1,ALB,APCDD1,BCL11B,BCL2L1,BMPER,CCL2,Ccl2,CCL28,CD14,CDKN1A,CLEC10A,CXCL3,DLL1,DUSP1,Elf5,EPHA2,GADD45A,GBP4,GJB2,GRHL1,INHBA,IRS1,ITGAD,KDR,KRT17,KRT7,MYC,MYOCD,NRP1,Oasl2,ODC1,PLAT,PLAUR,PPARA,PPL,SERPINE1,SERPINH1,SOX2,SPHK1,TGM1,THBS1,TNFRSF19,TNFSF10,TXNRD1,USP18,WNT5A,ZC3H12A | 439 (19) |
| NFE2L2 | -1.60e-01 | transcription regulator | NA | 1.47e+00 | 0.0e+00 | ABCB11,ABCC2,ADAMTS1,APCS,ATF3,ATF4,ATP1A1,BCL2L1,Ccl2,CCL4,CDKN1A,CHORDC1,CPT1A,CXCL10,CXCL2,CXCL3,CXCL6,Cyp4a14,DNAJB5,DYNLL1,F10,FASN,FKBP5,FTL,GADD45G,GCLC,GNAI2,Gsta1,HIPK2,HMOX1,IFRD1,IL1A,IL1R2,IL24,IL6R,ISG15,ITGB7,KCNMB4,KDR,MAFF,MAP1LC3B,MMP9,Mt1,NAT8B,NOCT,NR0B2,OGT,OSGIN1,PKIA,Pmaip1,PPARGC1B,PRKCB,PSAT1,PTGS2,PTPRO,RSAD2,RUNX1T1,SAT1,SERPINE1,SLC10A1,SLC38A3,SOCS3,SYT1,TCN2,TIMP3,TXNRD1,UBC | 497 (19) |
| FOXA1 | -1.70e-01 | transcription regulator | NA | 1.47e+00 | 0.0e+00 | ACTC1,ADH1C,AGR2,AQP1,AQP3,BMP2,CDKN1A,CXCL10,DDIT4,EFHD1,ELK3,ERBB3,FOXC1,GBP2,HNF4A,MGP,MUC5B,MYC,MYOCD,PCK1,PPARA,RASSF1,SLC10A6,SPSB1,TNFRSF12A | 504 (19) |
| IL36A | NA | cytokine | NA | 1.47e+00 | 0.0e+00 | CXCL10,CXCL2,CXCL3,CXCL6,IL12B,IL1A,LCN2,MMP9,S100A8 | 311 (14) |
| Cdk | NA | group | NA | 1.46e+00 | 0.0e+00 | CCL2,CXCL10,CXCL2,DDIT4,DUSP1,GADD45A,GADD45G,MYC,MYCN,NEDD9,TXNIP | 469 (18) |
| pirinixic acid | NA | chemical toxicant | NA | 1.46e+00 | 0.0e+00 | Acot1,ADH1C,APCS,AQP3,BMP7,C9,CCL2,Ccl2,CD5L,CDKN1A,CIDEA,CPT1A,CPT1B,CREB3L3,CRP,CXCL3,Cyp4a14,CYP7B1,DYNLL1,F3,FASN,G0S2,GADD45A,GADD45B,GLUL,HMOX1,HNF4A,HPX,JUNB,KDR,LCN2,LGALS3,LPIN2,MAP3K8,MMP9,MYC,NFKBIA,NPC2,PDK4,PEX11A,PLIN5,POR,PPARA,PTGS2,PTPRC,SERPINE1,SLC16A5,SLC23A1,THRB,TRIM63 | 568 (22) |
| MVP | -4.00e-02 | other | NA | 1.46e+00 | 0.0e+00 | CD83,CXCL2,CXCL3,CXCL6,FOS,MMP9 | 533 (24) |
| N-nitro-L-arginine methyl ester | NA | chemical drug | NA | 1.46e+00 | 0.0e+00 | ATF3,BCL2L1,CCL2,Ccl2,Ccr2,CD83,CXCL2,CXCL3,HMOX1,IL12B,MMP9,NFKBIA,PDK4,PTGS2,SELE,SERPINE1,TIMP1 | 403 (15) |
| TNFRSF1A | 3.40e-01 | transmembrane receptor | NA | 1.45e+00 | 0.0e+00 | APCS,BCL2L1,CCL19,CCL2,Ccl2,CCL4,CD83,CDKN1A,CXCL10,CXCL2,CXCL3,DIO2,IER3,IL12B,IL1A,IL24,KDR,LCN2,MMP9,Podxl,POU2AF1,SELE,SELL,SELP,SERPINE1,Slco1a1,SOCS3,TBX21,TGFA | 464 (15) |
| PRKCD | -5.00e-01 | kinase | NA | 1.45e+00 | 0.0e+00 | BCL2A1,BCL2L1,C3orf52,CCL2,Ccl2,CDKN1A,CEMIP,CIITA,CXCL10,FOS,FOSL1,FOSL2,GEM,GLI1,IL12B,JUNB,LIF,MAP1LC3B,MMP9,MUC5B,MYC,NFKBIA,NOCT,NR0B2,ODC1,OSR2,PTGS2,SERPINE1,SETBP1,SOX2,SPHK1,TPBG,ZFP36 | 460 (18) |
| 2,4-dinitrofluorobenzene | NA | chemical toxicant | NA | 1.44e+00 | 0.0e+00 | Ccl2,CCL4,CXCL10,CXCL2,GCLC,IL12B,IL24,PPARA,PTGS2 | 540 (17) |
| pilocarpine | NA | chemical drug | NA | 1.44e+00 | 0.0e+00 | EDN1,FOS,HK2,JUNB,LGALS3,NGFR,PDK4 | 463 (20) |
| OSM | 1.90e-01 | cytokine | NA | 1.44e+00 | 0.0e+00 | ADAMTS1,ADAMTS4,ADAMTS5,ALB,ANXA3,ARL4A,ATF3,ATP2B4,BAIAP2,BBOX1,BHLHE40,CCL2,Ccl2,CCL24,CDC42EP4,CDKN1A,CEBPD,CLDN4,COL2A1,CRP,CTSH,CTSV,CXCL10,CXCL2,CXCL3,CXCL6,ERBB3,F3,FASN,FGA,FOS,FOSL1,FOXC1,GADD45G,GAS7,GBP2,GLUL,GNRH1,HK2,HMOX1,HSD11B2,IER3,IL1R2,IL33,IL4R,IL6R,IRS1,JAK3,JUNB,KCNG1,KRT17,LCN2,LIF,MAOA,MAP2K6,MKNK2,MMP8,MMP9,MX1,MYC,NEDD4L,NELL2,OSMR,P2RY10,PFKFB3,PGF,PLCD1,S100A8,SELE,SELP,SERPINB1,SERPINE1,SLC16A3,SLC4A8,SOCS3,SPNS2,ST8SIA1,STAT1,TIMP1,TIMP3,TNFRSF19,TPBG,WNT5A,XDH,ZFP36 | 559 (20) |
| UGCG | 6.00e-02 | enzyme | NA | 1.43e+00 | 0.0e+00 | ABCB1,BCL2L1,CDKN1A,PCK1,SLC38A3 | 410 (13) |
| G protein alpha i | NA | group | NA | 1.43e+00 | 0.0e+00 | ADAMTS1,ADAMTS9,ATF3,CD274,CEBPD,CXCL10,FOS,FOSL1,FOSL2,GBP2,GBP4,GBP5,GBP7,GEM,Igtp,Irgm1,ISG15,LIF,MAFF,Oasl2,RAB20,RSAD2,SOCS3,SPHK1,TGM1,THBS1,TIMP1,TNFRSF12A,USP18 | 403 (19) |
| romidepsin | NA | biologic drug | NA | 1.42e+00 | 0.0e+00 | BCL2A1,BCL2L1,CDKN1A,CXCL10,DUSP1,EZH2,FOS,GADD45G,MMP9,MYC,PLAUR,PTGS2,RAB3IP,TIMP3,TNFAIP6 | 434 (18) |
| INSR | 2.00e-01 | kinase | NA | 1.42e+00 | 0.0e+00 | AGR2,ALB,ANKRD1,AQP1,ARL4A,ARRDC3,ATF3,ATP1A1,ATP1B1,BCL2A1,CCL2,Ccl2,CCL4,CD83,CDKN1A,CERS6,CKMT1A/CKMT1B,CLCA1,CPT1A,CPT1B,CTSV,CXCR4,DLK1,DUSP1,EDN1,EREG,FASN,FOS,GADD45A,HNF4A,HPX,IER3,IFITM2,IRS1,JUNB,LAT2,MAOA,MAOB,MMP9,MYC,MYCN,NR5A2,PCK1,PDGFB,PDHA1,PDK4,PECR,PEMT,PNPLA2,PPARA,PPARGC1B,PTPRN,RGS16,SAT1,SEC14L2,SERPINB1,SERPINE1,SIX4,SOCS2,SOCS3,SOX2,SOX7,ST8SIA2 | 434 (20) |
| diphtheria toxin | NA | chemical - endogenous non-mammalian | NA | 1.41e+00 | 0.0e+00 | Ccl2,CD163,CD274,CD79A,CPT1B,CTSW,DCLRE1B,ERBB3,FOS,IL12B,IL1A,IL1R2,LRRC32,LTB,MERTK,OPHN1,PFKFB3,PPARA,S100A8,SOCS3,TGFBR3,Tlr12,TRPM2 | NA |
| OSCAR | 4.40e-01 | other | NA | 1.41e+00 | 0.0e+00 | CCL24,CD83,CX3CR1,CXCL2,CXCL3,IL12B,IL1A,MAP3K8,TNFSF10 | 483 (17) |
| SS18 | -1.00e-02 | transcription regulator | NA | 1.41e+00 | 0.0e+00 | DLL1,DUSP9,GADD45B,NGFR,PDGFB,SLC16A3,SOCS3,SOX2,TLE3 | NA |
| TAS4464 | NA | chemical drug | NA | 1.41e+00 | 0.0e+00 | ATF4,BCL2A1,CDKN1A,FOS,GADD45A,MYC,SLC7A5,TIMP1 | 392 (11) |
| clofibrate | NA | chemical drug | NA | 1.41e+00 | 0.0e+00 | Acot1,BAAT,BMP7,CPT1A,Cyp4a14,GADD45A,HMOX1,Mt1,MYC,PEX11A,PPARA,PTGS2,Slco1a1 | 430 (17) |
| SIX2 | -3.00e-01 | transcription regulator | NA | 1.41e+00 | 1.0e-02 | CAMK1D,CCL28,CDKN1A,DLK1,IAPP,ICA1,IL1A,MAP3K8,PTPRN | NA |
| ACE | 2.90e-01 | peptidase | NA | 1.41e+00 | 2.0e-02 | CCL17,CCL2,CCL24,IL4R,SERPINE1 | NA |
| PARG | -1.00e-02 | enzyme | NA | 1.41e+00 | 2.0e-02 | NELL2,PTGS2,RAPGEF4,SOCS2 | NA |
| cyclosporin A | NA | biologic drug | NA | 1.41e+00 | 0.0e+00 | ABCC2,ABLIM1,ADORA1,ADORA2A,ADORA2B,APOB,ATF3,ATP1A1,BCL2L1,BMP2,CBLB,CCL2,CCL4,Ccr2,CCR9,CD14,CD163,CD40LG,CD83,CDKN1A,CLDN4,CR2,CREB1,Ctla2a,CX3CR1,CXCR4,DDIT4,EDN1,EDNRA,F3,FASN,FCER2,FGA,FKBP5,FOS,GZMA,GZMB,HMOX1,HNF4A,HPX,IER3,IL12B,IL1A,IRF4,ITGB7,KCNA5,KDR,KLRD1,LCN2,LGALS3,LTA,LYVE1,MMP9,MYC,MYOCD,NFKBIA,NGFR,ODC1,PRF1,PRKCH,PTGS2,RBM3,Rcan1,SELE,SELL,SERPINE1,SERPINH1,SPHK1,TBX21,TIMP1,TLE3,TNFRSF12A,TNFSF10,TRA2A,UPP1,WNT5A,XCL1,XCR1 | 495 (18) |
| LGALS3 | 6.40e-01 | other | NA | 1.41e+00 | 0.0e+00 | ABCB1,CCL2,Ccl2,CDKN1A,CTSH,CTSV,CXCL2,CXCL3,FASN,LGALS12,MYC,PNPLA2,SELE,SOCS3 | 490 (21) |
| nickel | NA | chemical toxicant | NA | 1.41e+00 | 1.0e-02 | FOS,Mt1,NUPR1,PLAT,SERPINE1 | 471 (19) |
| PADI2 | -2.50e-01 | enzyme | NA | 1.41e+00 | 0.0e+00 | ADAMTS9,Ccl2,CXCL2,CXCL3,CXCL6,MYC,PTGS2 | 236 (10) |
| CLDN7 | -8.00e-02 | other | NA | 1.41e+00 | 0.0e+00 | ABLIM1,ANXA3,CA12,CBX2,CCNA1,F3,FOSL1,GRINA,IFI44,LGALS3,MMP9,MUC13,MX1,SDCBP2,SERPINB1,SOSTDC1,SYTL2,TINAGL1 | NA |
| 1-chloro-2,4-dinitrobenzene | NA | chemical drug | NA | 1.40e+00 | 0.0e+00 | Ccl2,CCL4,GCLC,HMOX1,IL1R2,IL24,TXNRD1 | NA |
| Hif1 | NA | complex | NA | 1.40e+00 | 0.0e+00 | CD83,CDKN1A,CXCR4,DDIT4,EDN1,HIF3A,HMOX1,KCNA2,LPIN1,S100A8,SERPINE1,SLC16A3 | 427 (15) |
| beta-glycerophosphoric acid | NA | chemical - endogenous mammalian | NA | 1.40e+00 | 1.0e-02 | Acan,BMP2,CDKN1A,MGP,PTGS2 | 150 (7) |
| metribolone | NA | chemical reagent | NA | 1.40e+00 | 1.0e-02 | ADAMTS1,ADH1C,AGR2,AR,ARG2,ATP1B1,AZGP1,BCL2L1,CA4,CCNA1,CDKN1A,CXCR4,EDEM1,ERRFI1,ESRRG,FASN,FKBP5,FOS,GADD45G,HK2,IFITM2,MAOA,MCCC2,MERTK,MYC,NEDD4L,OXA1L,PDHA1,PNKD,POR,SAT1,SLC16A3,SLC25A10,SLC38A2,SPON2,STEAP2,SYTL2,THBS1,TXNIP,WDR19 | 619 (23) |
| cerivastatin | NA | chemical drug | NA | 1.40e+00 | 0.0e+00 | BMP2,CCL2,CD40LG,CDKN1A,F3,HMOX1,MMP9,MYC,NFYA,PLAT,PLAUR,PPARA,PTGS2,S100A8,SERPINE1,TGFBR3 | 332 (15) |
| CD14 | 1.21e+00 | transmembrane receptor | NA | 1.39e+00 | 0.0e+00 | BCL2A1,CCL2,Ccl2,CCL4,CXCL10,CXCL2,F3,IFIT1,IL12B,PTGS2,SELE,SELP,SOCS3 | 299 (16) |
| ARHGAP21 | 3.60e-01 | other | NA | 1.39e+00 | 0.0e+00 | ARID5A,CXCL10,CXCL2,HDC,LMO4,LTA,MERTK,Mx2,PLA1A,PLAT,PTGS2,RILPL1,TNFSF8 | NA |
| ziritaxestat | NA | chemical drug | NA | 1.39e+00 | 0.0e+00 | ADAMTS5,C3AR1,CEMIP,DDIT4,GBP2,HMOX1,IFIT1,LPAR1,MX1,OAS2,STON2,TNFSF10,USP18 | NA |
| Angiotensin II receptor type 1 | NA | group | NA | 1.39e+00 | 0.0e+00 | ATP1A1,CCL2,CXCL10,EDN1,SERPINE1,TIMP1 | 467 (21) |
| bempedoic acid | NA | chemical drug | NA | 1.39e+00 | 0.0e+00 | ADGRE1,CCL2,CCL4,CD40LG,CXCL10 | 410 (13) |
| epothilone B | NA | chemical drug | NA | 1.39e+00 | 0.0e+00 | BTG2,CDKN1A,SFN,THBS1,TNFSF10 | 337 (7) |
| spermidine | NA | chemical - endogenous mammalian | NA | 1.39e+00 | 0.0e+00 | CDKN1A,FOS,HMOX1,ODC1,SAT1 | 501 (21) |
| prostaglandin E1 | NA | chemical - endogenous mammalian | NA | 1.39e+00 | 0.0e+00 | Acan,CD14,CREM,FOS,MYC | 466 (22) |
| MYOG | -1.60e-01 | transcription regulator | NA | 1.39e+00 | 3.0e-02 | CDKN1A,FOS,PRIMA1,SCN4A,TRIM63 | NA |
| mir-802 | NA | microRNA | NA | 1.38e+00 | 1.0e-02 | ARL15,ARRDC3,CD14,CDH26,CDH6,CREB1,CXCR4,EPHA4,GABRP,MGAM,PDGFD,PPP1R1B,SDC4,SLC28A3,TESC,WNK2 | NA |
| memantine | NA | chemical drug | NA | 1.38e+00 | 2.0e-02 | ATP2B4,BCL2L1,CLDN5,CREM,EPHA4,FOS,GLUL,JUNB,NFKBIA,POR,PPP1R1B,SYT1 | NA |
| medroxyprogesterone acetate | NA | chemical drug | NA | 1.37e+00 | 0.0e+00 | ABL1,ADAMTS1,ARNT2,BCL2L1,BTG2,CCL2,Ccl2,CCL4,CD40LG,CDKN1A,CSF3R,CXCL10,CXCR4,EDN1,ENC1,ERBB3,F3,FAM107A,FASN,FOSL1,GLI1,GLUL,HYAL3,ID4,IL12B,IL1A,IL24,IL4R,IL6R,INHBA,ITGA7,JUNB,LIF,LIMK1,LTB,MAOA,MAOB,MYC,MYLK3,NFKBIA,ODC1,OGT,P4HA1,P4HA2,PBK,PDGFB,PDGFD,PPL,PTGER3,RASGRF1,RPS6KA6,SAT1,SERPINE1,SHC2,STAT1,TFPI2,THBS1,WNT11,WNT5A,ZBTB16 | 614 (20) |
| TXNIP | 6.00e-01 | other | NA | 1.36e+00 | 0.0e+00 | Acot1,CDKN1A,Cyp4a14,DDIT4,FASN,G0S2,IAPP,IL2RB,PPARA,PTGS2,TXNIP | 517 (22) |
| Jnk | NA | group | NA | 1.36e+00 | 0.0e+00 | BCL2L1,CCL2,Ccl2,CCL4,CCR9,CD69,CD83,CLEC10A,CXCL3,CXCL6,CXCR4,DUSP1,EDN1,F2RL1,F3,FOS,GADD45A,HMOX1,HNF4A,IL12B,IL1A,ITGB7,MMP9,MYC,PDGFB,PLAT,PLAUR,PLG,PTGS2,SELE,SERPINE1,SESN2,SOCS3,TIMP1,TINAGL1,TNFRSF12A,TRPC3,ZFP36 | 400 (16) |
| GNRH1 | 6.30e-01 | other | NA | 1.36e+00 | 0.0e+00 | APCDD1,CREM,FOS,GNRH1,INHBA,JUNB,Pcdhb6,PLAT,PTGS2,RASSF10 | 512 (21) |
| TLR3 | 1.00e-01 | transmembrane receptor | NA | 1.35e+00 | 0.0e+00 | ADAMTS4,ARG2,ATF3,BCAR3,CCL17,CCL2,Ccl2,CCL4,CD274,CD69,CLCA1,CMPK2,CXCL10,CXCL2,CXCL3,DUSP1,EDN1,FOS,GADD45B,GBP2,GBP4,HMOX1,IER3,IFI44,IFI44L,IFIT1,IL12B,IL1A,IL1R2,IL33,ISG15,JUNB,Klrk1,LCN2,LPIN2,MAP3K8,MX1,Oasl2,PFKFB3,PROCR,PTGS2,PTX3,RSAD2,S100A8,SELE,SERPINE1,SOCS3,STAT1,TIMP1,TNFSF10,TREML2,USP18 | 426 (18) |
| BSG | 6.00e-02 | transporter | NA | 1.35e+00 | 0.0e+00 | ABCC2,BCL2L1,CD40LG,CRP,CXCL3,CXCL6,IL1A,KDR,MMP9,PLAUR,SELP,SERPINE1 | 507 (19) |
| NLRP3 | -2.70e-01 | other | NA | 1.35e+00 | 0.0e+00 | Ccl2,CCL24,CCL4,CCR3,CD274,CD69,CXCL10,CXCL2,CXCL3,HMOX1,IL22RA2,IL33,LIF,MMP9,PTGS2,STAT1,TBX21,TIMP1 | 404 (17) |
| KITLG | -4.90e-01 | growth factor | NA | 1.35e+00 | 0.0e+00 | BCL2L1,CCL2,Ccl2,CCL4,CD14,CD3G,CDKN1A,CSF3R,CXCL2,CXCL3,CXCR4,FOS,HMOX1,IL1A,ITGA2B,KDR,NFKBIA,PDGFB,PIK3IP1,Podxl,PRKCB,PTGER3,PTGS2,SLC20A2,SNAP23,TXNIP | 337 (15) |
| MAPK8 | 3.00e-02 | kinase | NA | 1.35e+00 | 0.0e+00 | ABCB1,ABCB11,AQP1,BAAT,BCL2L1,BMP2,Ccl2,CDKN1A,CRP,DIO2,DUSP1,FCER2,FOS,FOSL1,FOSL2,GADD45A,HMOX1,IL12B,LIF,MAOB,MMP9,MUC5B,MYC,NRP1,PLAUR,PPARGC1B,PTGS2,PTX3,SELE,SESN2,SLC10A1,TBX21,TRH,WNT5A,ZFP36 | 437 (16) |
| PRKCB | -5.90e-01 | kinase | NA | 1.35e+00 | 0.0e+00 | BCL2L1,CD83,CDKN1A,FASN,FOS,MMP9,MYC,NR0B2,PFKFB3,PPP1R3C,PRKCB,PTGS2,SERPINE1 | 462 (19) |
| ACSL4 | 5.60e-01 | enzyme | NA | 1.35e+00 | 2.0e-02 | AR,CAMK1D,Ccl2,FERMT1,PTGS2,SAT1,SELL,STAT1 | NA |
| TAC1 | -9.00e-02 | other | NA | 1.35e+00 | 0.0e+00 | CCL2,Ccl2,CCL4,CXCL10,CXCL3,CXCR4,FOS,GNRH1,HDC,HMOX1,IL1A,PLAT,PRF1,PTGS2,SELE,SELP,SERPINE1,SLC6A2 | 366 (16) |
| ATAD3A | 4.50e-01 | other | NA | 1.35e+00 | 0.0e+00 | CYP46A1,IFI44L,IFIT1,ISG15,RSAD2 | 180 (7) |
| PTPRJ | 9.00e-02 | phosphatase | NA | 1.34e+00 | 0.0e+00 | ARID5A,CCL4,CD69,CEBPD,CXCL2,CXCL3,EDN1,FOS,HDC,IL1A,INHBA,LTA,MERTK,Mx2,PLA1A,PLAT,PLAUR,PTGS2,RILPL1,TNFSF8,ZC3H12A | 463 (20) |
| rolipram | NA | chemical drug | NA | 1.34e+00 | 0.0e+00 | CCL2,CXCR4,DUSP1,FOS,IL1R2,MMP9,PTGS2,SFTPB,SOCS3,TLR5 | 399 (18) |
| finasteride | NA | chemical drug | NA | 1.34e+00 | 0.0e+00 | AR,EDN1,FOS,IL24,KDR,TGFA | 252 (7) |
| Fibrinogen | NA | complex | NA | 1.34e+00 | 0.0e+00 | CCL2,Ccl2,CCL4,CXCL3,F3,SELP | 362 (17) |
| BTC | -4.90e-01 | growth factor | NA | 1.34e+00 | 0.0e+00 | EREG,FASN,MMP9,PTGS2,TNFAIP6 | 485 (19) |
| WWTR1-CAMTA1 | NA | fusion gene/product | NA | 1.34e+00 | 0.0e+00 | ATF3,CEBPD,CXCL2,SERPINE1,SOX7 | NA |
| SUPT20H | NA | other | NA | 1.34e+00 | 1.0e-02 | BCL2A1,CCL4,LTA,NFKBIA,XCL1 | 217 (7) |
| wood smoke particle | NA | chemical reagent | NA | 1.34e+00 | 1.0e-02 | ARNT2,IL1A,IL24,KRT17,MAFF | NA |
| SH3PXD2A-AS1 | NA | other | NA | 1.34e+00 | 1.0e-02 | IER3,SERPINE1,SFN,TGFA,TRPM2 | 399 (11) |
| vanillin | NA | chemical - endogenous non-mammalian | NA | 1.34e+00 | 1.0e-02 | DDIT4,GCLC,HMOX1,MARK4,TRIM16 | NA |
| HOXC8 | 0.00e+00 | transcription regulator | NA | 1.34e+00 | 4.0e-02 | ANKRD1,Ccl2,CXCL10,IL1R2,SLC16A3 | NA |
| Yaf2 | 2.00e-01 | transcription regulator | NA | 1.34e+00 | 5.0e-02 | ACTC1,DNAH12,KDR,Nes,SLC6A13 | NA |
| cycloheximide | NA | chemical reagent | NA | 1.34e+00 | 0.0e+00 | ABCB1,Acan,ACTC1,ALB,APOB,AQP1,AR,ATP2B4,BCL2L1,BTG2,CCL2,CCL4,CD8A,CDKN1A,CEBPD,COL2A1,CXCL10,CXCL2,CXCL3,CXCR4,DDIT4,DIO1,DIO2,DUSP1,EDN1,FOS,FOSL2,GADD45A,GADD45B,GADD45G,GAS7,GCLC,GHRHR,GNAI2,HMOX1,HNF4A,HSD11B2,IFIT1,IL1A,IL1R2,IL24,IL4R,JUNB,LARP6,LCN2,Mt1,MYC,MYCN,MYLK3,NFKBIA,PDGFB,PFKFB3,PLAT,PLAUR,PTGS2,PTX3,RBM3,RERG,RSAD2,S100A8,SELE,SELP,SERPINE1,SOCS3,TGFA,THBS1,THRB,TIMP1,TNFAIP6,TNFSF10,TRA2A,XDH | 489 (14) |
| deoxycorticosterone acetate | NA | chemical drug | NA | 1.34e+00 | 1.0e-02 | Eda,EDN1,PTGS2,SELE,SELP | NA |
| nicotine | NA | chemical drug | NA | 1.34e+00 | 0.0e+00 | ARG2,BMP2,CCL2,Ccl2,CCL4,CDKN1A,CHRNA7,CXCL3,EDN1,ERN1,FASN,FOS,HCRTR1,HMOX1,HSD11B2,IKBKE,IL12B,IL1A,JUNB,KCNJ11,KDR,LGALS3,MMP9,MYCN,PLAT,PLAUR,PTGS2,RYR2,SELE,SERPINE1,STAT1,TFPI2,TGM1,WNT5A,WNT7A,ZFP36 | 347 (15) |
| ATP-gamma-S | NA | chemical reagent | NA | 1.32e+00 | 0.0e+00 | CCL2,CCL24,CCL4,CD69,CD83,CD8A,CREM,CXCL2,CXCR4,EREG,IL1A,IL1R2,IRF4,MMP9,NRP1,SOCS3,TGFA,THBS1,TLR5,TRH | 516 (16) |
| MAPKAPK2 | 3.80e-01 | kinase | NA | 1.31e+00 | 0.0e+00 | CCL2,Ccl2,CEBPD,CXCL10,CXCL2,CXCL3,HDC,LMO4,LTA,MMP9,NFKBIA,PLA1A,PLAT,RILPL1,ZFP36 | 463 (15) |
| MAPK3 | 2.40e-01 | kinase | NA | 1.31e+00 | 0.0e+00 | APOB,CD69,CDKN1A,FOS,FOSL1,FOSL2,HDC,JUNB,MMP9,MYC,PDGFB,PLAUR,PPARA,PTGS2,SELE,SELL,THBS1,TIMP1 | 434 (20) |
| geldanamycin | NA | chemical drug | NA | 1.31e+00 | 1.0e-02 | AR,BCL11B,BCL2L1,CEBPD,CHORDC1,CIITA,EGR3,FASN,FKBP5,IRS1,KCNA5,LCK,LGI3,LIF,MAP4K1,MYC,OPTC,PRIMA1,PTGS2,SLC5A1,SMARCA1,SPN,STAT1,TPPP,ZC3H12D | NA |
| doxycycline | NA | chemical drug | NA | 1.30e+00 | 0.0e+00 | ADGRE1,BCL2L1,BMP2,CCL19,Ccl2,CEBPD,CSF3R,CXCL3,GFI1,MMP8,MMP9,MUC5B,Pln,PTGS2,TIMP1,XDH | 474 (18) |
| fluvastatin | NA | chemical drug | NA | 1.30e+00 | 0.0e+00 | BCL2L1,CDKN1A,EDN1,HMOX1,PLAT,PON1,PTGS2,SERPINE1,TNFSF10 | 487 (21) |
| TGFB2 | 2.40e-01 | growth factor | NA | 1.30e+00 | 0.0e+00 | BHLHE40,CIITA,EDN1,FOS,HMOX1,ID4,INHBA,KDR,MMP9,OSR1,PDK4,RUNX1T1,S100A8,SELL,SERPINE1,SESN1,SPHK1,TGFBR3,THBS1,TIMP1,WNT11 | 517 (21) |
| EREG | 8.60e-01 | growth factor | NA | 1.30e+00 | 0.0e+00 | CXCL3,EREG,IL12B,PGF,PTGS2,TGFA,TNFAIP6 | 471 (18) |
| ITGAV | -1.10e-01 | transmembrane receptor | NA | 1.30e+00 | 0.0e+00 | BCL2L1,Ccl2,CCL4,CD14,CDKN1A,CXCL10,FOS,GBP2,MMP9,SERPINE1,TIMP1 | 390 (17) |
| ozone | NA | chemical toxicant | NA | 1.29e+00 | 0.0e+00 | AGR2,Ccl2,CCR3,CXCL10,CXCL2,CXCL3,F3,FOS,HMOX1,JUNB,MUC5B,SOCS3 | 356 (14) |
| DDB1 | 5.00e-02 | other | NA | 1.29e+00 | 0.0e+00 | BTG2,CDKN1A,CEBPD,EGR3,FOS,STAT1,TRIB1,ZFP36 | NA |
| trans-cinnamaldehyde | NA | chemical drug | NA | 1.29e+00 | 0.0e+00 | CDKN1A,GCLC,HMOX1,LTA,POR,PTGS2,SERPINE1,TXNRD1 | 223 (8) |
| CSF2RA | 2.30e-01 | transmembrane receptor | NA | 1.29e+00 | 0.0e+00 | ADGRE1,FOS,JUNB,MYC,SNAP23 | 420 (21) |
| VIPR1 | 2.80e-01 | G-protein coupled receptor | NA | 1.29e+00 | 0.0e+00 | Ccl2,CCL4,CXCL10,CXCL2,CXCL3 | 327 (19) |
| carbon tetrachloride | NA | chemical toxicant | NA | 1.29e+00 | 0.0e+00 | ABCC2,ADGRE1,APOB,ATF3,BCL2L1,BMP3,C9,Ccl2,CCL4,CDKN1A,CX3CR1,CXCL10,CXCL6,DUSP1,FGFR4,FOS,GADD45A,GADD45B,GBP5,GCLC,HMOX1,JUNB,KDR,MMP9,Mt1,MYC,NR0B2,ODC1,PDGFB,PDGFD,PON1,PRKCH,PTGS2,RGN,SLC10A1,Slco1a1,SLCO1C1,SPHK1,TGFA,TIMP1,TIMP3,TNFRSF12A | 522 (18) |
| methamphetamine | NA | chemical drug | NA | 1.28e+00 | 0.0e+00 | ADGRE1,BCL2L1,BMP7,Ccl2,CREM,FOS,FOSL1,FOSL2,GBP2,HMOX1,IL1A,KLF12,MAOA,MAP3K6,MMP9,MYC,NAT8L,PCLO,RTKN2,SFN,TRH | 529 (22) |
| hemoglobin | NA | complex | NA | 1.28e+00 | 1.0e-02 | CD163,CDKN1A,EDN1,HMOX1 | NA |
| emodin | NA | chemical drug | NA | 1.28e+00 | 0.0e+00 | ABCB1,AR,Ccl2,CDKN1A,CLDN4,CLDN5,CXCL10,CXCL3,CXCR4,HLA-DOB,IRF4,MMP9,SELE | 383 (17) |
| RACK1 | 2.30e-01 | enzyme | NA | 1.28e+00 | 0.0e+00 | ADCYAP1R1,BCL2L1,CDKN1A,FOS,GLI1,IFI44,ISG15,MYC,RSAD2 | 393 (18) |
| NOX4 | -4.70e-01 | enzyme | NA | 1.28e+00 | 0.0e+00 | BCL2L1,CCL2,Ccl2,CDKN1A,GCLC,HK2,HMOX1,SERPINE1,TGFA | 404 (16) |
| TNFSF12 | -3.00e-02 | cytokine | NA | 1.28e+00 | 0.0e+00 | BCL2L1,CCL19,CCL2,Ccl2,CCL24,CXCL10,CXCL2,CXCL3,CXCL6,DLL1,HEYL,IL1R2,KLF15,MMP9,NFKBIA,PTX3,S100A8,SELE,SIX1,TIMP1,TNFRSF12A,TRIM63 | 398 (13) |
| CASP4 | 5.00e-01 | peptidase | NA | 1.28e+00 | 0.0e+00 | CCL2,CD14,CXCL2,CXCL3,CXCL6,IL1A,LCN2,MMP9,PGLYRP1,TNFSF8,TRPM2 | 436 (19) |
| DGCR8 | -2.10e-01 | enzyme | NA | 1.28e+00 | 2.0e-02 | ERBB3,FOS,ID4,MYC,NGFR,SMO,SOX2 | NA |
| nitroprusside | NA | chemical drug | NA | 1.27e+00 | 1.0e-02 | BCL2L1,CREB1,CXCL3,FOS,HMOX1,HSD11B2,MYC,PTGS2 | 296 (14) |
| NR1I3 | -5.30e-01 | ligand-dependent nuclear receptor | NA | 1.27e+00 | 0.0e+00 | ABCB1,ABCC2,APCS,CDKN1A,CYP7B1,DIO1,FASN,GADD45B,HNF4A,MAFF,Mt1,MYC,NEDD9,PCK1,POR,SAT1,SLCO1C1 | 366 (13) |
| mir-21 | NA | microRNA | NA | 1.27e+00 | 0.0e+00 | BTG2,CCL17,CCL19,CCL2,Ccl2,CD180,CD19,CD274,CDKN1A,CSF3R,CXCL10,CXCL2,EIF4E3,F830016B08Rik,FUBP1,GBP2,GBP5,GBP7,Hrg,IL6R,Irgm1,Klrk1,LTB,MMP9,MYC,OAS2,PBK,PLAT,PPARA,RNASE6,SESN1,SLC11A1,SOX2,Spry1,STAT1,TBX21,TGM1,TIMP3,UBA7 | 404 (16) |
| asoprisnil | NA | chemical drug | NA | 1.26e+00 | 0.0e+00 | AQP3,CTSW,G0S2,GZMB,HSD17B2,IL2RB,PRF1,RBP4,SFN,XDH | NA |
| USP19 | 1.70e-01 | peptidase | NA | 1.26e+00 | 0.0e+00 | CBLB,Ccl2,CXCL10,DDIT4,FKBP5,KLF15,LCN2,PFKFB3,TRIM63 | 371 (14) |
| CDK8 | 7.00e-02 | kinase | NA | 1.26e+00 | 3.0e-02 | CXCL2,CXCR4,DIO1,MYC,Podxl,TP73 | NA |
| Ca2+ | NA | chemical - endogenous mammalian | NA | 1.26e+00 | 0.0e+00 | ABCB1,Acan,ADORA2A,AR,ATF3,BCL2L1,CD19,CD83,CDKN1A,CEBPD,COL2A1,CREM,CXCR4,DNASE1L3,DUSP1,EDN1,FASN,FOS,FOSL1,FOSL2,GRK5,HDC,IAPP,IL33,IL6R,JUNB,KCNG1,MCAM,MGP,MMP9,MYOCD,Nes,NFKBIA,NGFR,ODC1,PER1,PNPLA1,PPARA,PTGS2,Rcan1,RNF152,S100A8,SELP,SERPINE1,SLC6A12,TGM1 | 569 (23) |
| SUMO2 | 3.00e-02 | enzyme | NA | 1.25e+00 | 0.0e+00 | ABCB11,CHRNA7,GRB14,Ifgga2l1/RGD1309362,IRS1,ISG15,MOXD1,NR0B2,TNFRSF21 | NA |
| pemetrexed | NA | chemical drug | NA | 1.25e+00 | 0.0e+00 | ARRDC3,CD14,CDKN1A,IL1A,IL24,LIF,NECTIN4 | NA |
| pyruvaldehyde | NA | chemical - endogenous mammalian | NA | 1.25e+00 | 0.0e+00 | ARG2,CD40LG,CDKN1A,GZMA,GZMB,HMOX1,PRF1,SELE | 422 (17) |
| NKX2-3 | NA | transcription regulator | NA | 1.25e+00 | 0.0e+00 | ADAMTSL2,BMP2,CBS/LOC102724560,CDKN1A,CHST7,CMPK2,CSRNP1,EDN1,F2RL1,FAR2,GALNT15,GBP2,GIMAP7,HSD17B2,KRT81,PKIA,PLA1A,Podxl,PSAT1,PTGS2,RNF213,SHOX2,SNCAIP,SOX2,STAT1,TFPI2,TNFSF18,UBA7,USP18 | NA |
| DDX5 | -2.20e-01 | enzyme | NA | 1.25e+00 | 2.0e-02 | CDKN1A,COL2A1,FOS,FOSL1,LCN2,MYC,TIMP1,WNT5A | NA |
| IL1R1 | 3.80e-01 | transmembrane receptor | NA | 1.25e+00 | 0.0e+00 | APCS,Ccl2,CXCL10,CXCL2,CXCL3,FOS,IL1A,MMP9,PTGS2,SELE,Slco1a1,TIMP1 | 339 (15) |
| CAMK4 | -4.30e-01 | kinase | NA | 1.24e+00 | 0.0e+00 | ATF3,CCL2,CD40LG,CDKN1A,CPT1B,CREM,F3,FOS,FOSL2,JUNB,S100A8 | 476 (18) |
| VTN | -1.10e-01 | other | NA | 1.24e+00 | 0.0e+00 | BCL2L1,BHLHE40,CDKN1A,CXCL3,F3,IRS1,MMP9,PLAUR,PTGS2,SERPINE1,SFN | 416 (22) |
| KDR | -7.20e-01 | kinase | NA | 1.24e+00 | 0.0e+00 | Ccl2,CXCR4,F3,HMOX1,KDR,LAG3,PTGS2,SELE,SOX18 | 462 (22) |
| POU4F1 | -5.00e-02 | transcription regulator | NA | 1.24e+00 | 0.0e+00 | ACTC1,ADGRG2,BCL2L1,CDKN1A,GAL,IRX1,LILRB3,NTRK3,Pmaip1,RBM24,RTN4RL2,SLC6A17,SSTR4,TRPV1 | NA |
| BAG3 | 9.00e-02 | other | NA | 1.24e+00 | 0.0e+00 | BCL2L1,CDKN1A,HK2,MAP1LC3B | 406 (12) |
| POR | 1.19e+00 | enzyme | NA | 1.24e+00 | 0.0e+00 | Acot1,APCDD1,CAPRIN2,CIITA,CPT1A,CYP7B1,EREG,FGL1,FOXC1,GADD45B,GBP2,HMOX1,KDR,MAP3K6,Mt1,NOCT,NR0B2,PDK4,PFKFB3,POR,SDC4,STAT1 | 349 (11) |
| PPP3R1 | 6.70e-01 | phosphatase | NA | 1.24e+00 | 0.0e+00 | AQP1,CPT1B,DLK1,Fam169b,GIMAP4,Gucy2g,IKZF3,LTA,PON1,PPARA,RYR2,SFTPB | 195 (7) |
| MMP1 | NA | peptidase | NA | 1.23e+00 | 0.0e+00 | CDKN1A,FOS,KDR,MMP9,MYC,MYOCD,NFKBIA,PTGS2,SERPINE1 | 417 (18) |
| AREG | 6.00e-01 | growth factor | NA | 1.23e+00 | 3.0e-02 | AURKB,BCL2L1,CXCR4,EREG,FOS,MMP9,PTGS2,PTX3,TNFAIP6,TXNRD1 | NA |
| NCOA3 | -3.00e-01 | transcription regulator | NA | 1.23e+00 | 0.0e+00 | ANKRD1,CDKN1A,FASN,GJB2,HK2,HMOX1,IRS1,KDR,MMP9,NFKBIA,OTUB2,PTGS2,SFTPB,SLC16A3,XDH | 504 (21) |
| IL11RA | 6.00e-02 | transmembrane receptor | NA | 1.23e+00 | 0.0e+00 | CCL17,Ccl2,CCL4,CLCA1,CXCL2,CXCL3,FOS,IL4R,JUNB,MMP9,MYC,SELP,SOCS3,SOX2,TIMP1 | 465 (16) |
| sodium chloride | NA | chemical - endogenous mammalian | NA | 1.23e+00 | 2.0e-02 | AQP1,Ccl2,CRP,CXCL2,DDIT4,EDN1,FOS,HMOX1,PTGS2,SLC6A12 | NA |
| 5-O-mycolyl-beta-araf-(1->2)-5-O-mycolyl-alpha-araf-(1->1’)-glycerol | NA | chemical - endogenous non-mammalian | NA | 1.23e+00 | 0.0e+00 | ADAMTS5,ADORA2A,ATF3,BCL2A1,CCL2,CCL4,CD83,CHST7,CX3CR1,CXCL10,CXCL2,CXCL3,DUSP1,IER3,IFIT1,IL1A,KYNU,MMP9,PTGS2,RGS16,RND3,SDC4,SOCS3,SPHK1 | 460 (14) |
| IL3 | NA | cytokine | NA | 1.23e+00 | 0.0e+00 | ADGRE1,ADGRE5,BCL2L1,BMP2,BTG2,CCL17,CCL19,CCL2,CCR3,CD14,CD3G,CD40LG,CD69,CD83,CDKN1A,CPT1A,CREM,CXCR4,DOK2,EGR3,FASN,FCER2,FGFR4,FOS,FOSL2,GADD45A,GADD45B,GADD45G,GZMA,HK2,HNF4A,IL12B,IL33,ITGB7,JUNB,LCN2,LIF,LTA,Mt1,MYC,NEDD9,NRP1,ODC1,RBM3,SELE,SELL,SEMA7A,SLC7A5,SOCS3,TNFSF10,TNFSF8 | 393 (14) |
| CSF1 | 1.00e-02 | cytokine | NA | 1.22e+00 | 0.0e+00 | ADGRE1,ADGRE5,BCL2L1,BHLHE40,CCL2,Ccl2,CD163,CD83,CDKN1A,CREB1,CTSH,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,DOK2,DUSP1,DUSP9,EGR3,F10,F2RL1,FOS,GAS7,HK2,IFIT1,IKBKE,IL12B,IL1A,IL2RB,IRF4,JUNB,LAG3,LYVE1,MERTK,MMP16,MMP9,MX1,MYC,OAS2,PFKFB3,PTPRC,SLC16A3,SLC7A5,SOCS2,STAT1,THBS1,TLR5,TRIM14,ZNF705A | 416 (18) |
| histamine | NA | chemical - endogenous mammalian | NA | 1.22e+00 | 0.0e+00 | BCL2L1,BMP2,CCL2,Ccl2,CCL4,CLCA1,CLDN4,CXCL10,CXCL2,CXCR4,F3,FOS,IL12B,PTGS2,SELE,SELP | 333 (15) |
| GRHL2 | 1.00e-02 | transcription regulator | NA | 1.22e+00 | 0.0e+00 | ARHGEF28,BMP2,CLDN4,ERBB3,MYC,RFX2,TGM1 | NA |
| ATM | -4.10e-01 | kinase | NA | 1.22e+00 | 1.0e-02 | BCL2L1,CDKN1A,DUSP1,GADD45A,GADD45B,GADD45G,HMOX1,IL33,LPIN1,SERPINE1 | 515 (19) |
| MTOR | -5.00e-02 | kinase | NA | 1.21e+00 | 0.0e+00 | AR,BCL2A1,BCL2L1,CCL2,CD274,CDKN1A,CEBPD,CKMT1A/CKMT1B,CPT1B,CXCL2,CXCR4,DDIT4,DUSP1,FASN,FOS,GZMB,HK2,HSD17B2,IL12B,IL1A,IL2RB,IL4R,IRS1,MAP1LC3B,MMP9,MYC,PDE4A,PDHA1,PDK4,PPARA,PPARGC1B,PRF1,SELL,SERPINB1,SLC16A3,SLC26A3,SOAT1,SOCS3,STAT1,TBX21,TLR5,TNFSF10,TPPP,TRIM63,TXNIP | 468 (23) |
| FGFR1 | -2.60e-01 | kinase | NA | 1.21e+00 | 0.0e+00 | Acan,ADAMTS5,BMP7,CDKN1A,CPT1A,CRISPLD2,DLL1,ERN1,FGFR4,FOS,GRINA,HK2,LIF,LOX,MYC,PDGFB,PLAUR,POU2F2,PPARA,PTGS2,SFN | 452 (20) |
| Trp53cor1 | NA | other | NA | 1.21e+00 | 5.0e-02 | Ccl2,CDKN1A,FZD10,Pmaip1 | NA |
| CLEC10A | 1.06e+00 | other | NA | 1.21e+00 | 0.0e+00 | CLEC10A,CRP,CXCL2,CXCL6,ENDOU,IL12B,KRT17,MAP3K6,MMP8,MMP9,Retnlg,ZBTB16 | NA |
| CD36 | 3.20e-01 | transmembrane receptor | NA | 1.21e+00 | 0.0e+00 | ADAMTS4,ADGRE1,APOB,Ccl2,CXCL3,CXCL6,ERN1,FASN,IL1A,LIF,PDGFB,PLAUR,Pln,PNPLA2,SELP,SERPINE1,TGFA | 496 (17) |
| ABL1 | 7.60e-01 | kinase | NA | 1.20e+00 | 0.0e+00 | ABL1,BMP2,CDKN1A,GADD45A,IER3,MMP9,MYC,TP73 | 480 (19) |
| ESR2 | -4.90e-01 | ligand-dependent nuclear receptor | NA | 1.20e+00 | 0.0e+00 | ABLIM1,ACTC1,ADAMTS1,ADAMTS5,ADCYAP1R1,ADORA1,ANO2,AQP3,AR,ARL4A,ARNT2,ASB2,ATF3,BCL2L1,BMP2,BTG2,CA12,CBS/LOC102724560,CCL2,CCL28,CD79A,CDKN1A,CEBPD,CLDN11,CLDN4,CTHRC1,CTSH,CXCL2,CYP26B1,EDN1,EGR3,EREG,ERN1,EZH2,F2RL1,FASN,FKBP5,FOS,FOSL2,GADD45B,GBP2,GCLC,GJB1,IFI44,IL1A,JUNB,KDR,KLHL38,KRT17,LMO4,LOX,LOXL1,LRRN3,MAOA,MAP2K6,MGP,MMP9,MYC,NEDD9,NELL2,NFKBIA,NFYA,ODC1,OTUB2,PDGFB,PDK4,PDLIM3,PLAT,PLAUR,PPP1R3C,PRKCH,PSAT1,PTGS2,PTX3,RASSF10,RBP4,RGCC,RSAD2,SDC4,SELE,SERPINE1,SERTAD4,SLC38A2,SOCS2,SOCS3,SPHK1,SPOCK1,ST8SIA1,ST8SIA6,TDRD5,TGFA,THBS1,TIMP1,TNFRSF12A,TRIB1,TRIM14,Tsc22d3,UCK2 | 655 (19) |
| fenofibrate | NA | chemical drug | NA | 1.20e+00 | 0.0e+00 | Acot1,APOB,AR,CCL2,Ccl2,CIDEA,CPT1A,CPT1B,CREB3L3,CRP,EDN1,FASN,FGA,GADD45A,GLUL,HMOX1,KDR,PDK4,PNPLA2,POR,PPARA,PTGS2,PTPRC,SERPINE1,THRB,TIMP1,TRIM63,TXNIP | 458 (22) |
| RAF1 | 9.00e-02 | kinase | NA | 1.20e+00 | 0.0e+00 | ANKRD1,CCL19,CD37,CDKN1A,CDON,CRP,CTSH,CXCL3,DIO2,EGR3,FGFBP1,FOS,HDC,HPCAL1,HSD11B2,IER3,IL12B,LIF,MAOB,MMP9,MYC,OSMR,PCK1,PLAT,PLAUR,PTGS2,RND3,SEC14L2,SELENBP1,TFPI2,TIMP1,TXNIP | 420 (17) |
| GH1 | NA | growth factor | NA | 1.20e+00 | 0.0e+00 | ATF3,ATF4,CD19,CEBPD,CREB1,CXCR4,ERBB3,FASN,FOS,GADD45A,GHRHR,IL4R,JUNB,Slco1a1,SOCS2,SOCS3,TRPA1,TRPV1,UBA7,ZFP36 | 522 (21) |
| BAG1 | 2.00e-01 | other | NA | 1.20e+00 | 0.0e+00 | BCL2L1,CDKN1A,FKBP5,FOS,GADD45A,NEDD4L,PTGS2,TP73 | 450 (19) |
| RPS6KB1 | 3.70e-01 | kinase | NA | 1.20e+00 | 0.0e+00 | ATP1A1,BCL2L1,CDKN1A,CXCL10,IL12B,IRS1,ISG15,SERPINE1 | 429 (17) |
| lipid A | NA | chemical toxicant | NA | 1.20e+00 | 0.0e+00 | CCL2,Ccl2,CD14,CXCL10,CXCL3,IL12B,PTPRC,THBS1 | 292 (17) |
| alendronic acid | NA | chemical drug | NA | 1.20e+00 | 1.0e-02 | Ccl2,CCL24,CRP,FMO3,MAP2K6,MMP9,OSMR | NA |
| GNRH | NA | group | NA | 1.19e+00 | 2.0e-02 | ATF3,BMP7,DUSP1,FOS,PTGS2,SEMA6B | NA |
| MMP11 | NA | peptidase | NA | 1.19e+00 | 4.0e-02 | ATF4,PPARA,PTGS2,SLC16A3 | NA |
| LEP | -1.00e-02 | growth factor | NA | 1.19e+00 | 0.0e+00 | ABCB11,ADGRE1,AQP3,AR,BCL2A1,BCL2L1,CCL2,Ccl2,CD14,CDKN1A,CIDEA,COL2A1,CPT1A,CPT1B,CRP,CTSV,CXCL10,Cyp4a14,DLK1,ECE1,EDN1,F3,FABP3,FASN,FOS,GADD45A,GAL,GCLC,GHRHR,GNRH1,HPX,IL12B,IL1A,IL1R2,Irgm1,IRS1,JUNB,KDR,LIF,MAP1LC3B,MUC5B,MYC,PCK1,PEMT,PLAT,Pln,PNPLA2,PPARA,PPARGC1B,PRF1,PTGS2,SELE,SELP,SERPINE1,SOCS3,THBS1,TIMP1,TIMP3,TNFSF10,TRH,TRPV1,WNT5A,ZFP36 | 466 (18) |
| TLR4 | -4.00e-01 | transmembrane receptor | NA | 1.18e+00 | 0.0e+00 | ADORA2A,ADORA2B,ARID5A,ATF3,BCL2L1,BMP2,CCL2,Ccl2,CCL4,CD14,CD163,CD274,CEBPD,CERS6,CMPK2,CREB3L3,CXCL10,CXCL2,CXCL3,CXCL6,DLK1,DOCK11,EDN1,EREG,F3,FASN,FOS,GADD45G,GBP2,HDC,HK2,HMOX1,Igtp,IL12B,IL1A,IL2RB,INHBA,Irgm1,ISG15,LCN2,LMO4,LTA,LYVE1,MERTK,MMP9,MX1,Mx2,MYC,NFKBIA,PLA1A,PLAT,PTGS2,PTX3,RGCC,RGS16,RGS18,RILPL1,RSAD2,S100A8,SELE,SELP,SLC6A12,SOCS3,SPHK1,STAT1,TNFSF10,TNFSF8,TREM3,TRIM63,ZC3H12A | 562 (15) |
| di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone | NA | chemical drug | NA | 1.18e+00 | 1.0e-02 | AR,ERRFI1,GLI1,MYC | 296 (7) |
| A2M | 5.00e-01 | transporter | NA | 1.18e+00 | 0.0e+00 | ATF4,Ccl2,CCL4,CREB1,ERN1,FASN,GADD45B,WNT5A | 395 (20) |
| CASR | -9.00e-02 | G-protein coupled receptor | NA | 1.18e+00 | 0.0e+00 | ABCC2,ABL1,Acan,AGR2,BCL2L1,BMP7,CXCL10,EDN1,EZH2,GADD45A,GADD45G,GNAI2,IER3,ISG15,ITGB7,NEDD9,NUPR1,ODC1,PON1,PTGS2,RGCC,RNF144A,S100A8,SLC7A7,SOCS3,TXNIP | 460 (19) |
| CYP19A1 | -3.00e-01 | enzyme | NA | 1.18e+00 | 0.0e+00 | AR,B3GNT5,CD14,CXCL10,FAM107A,FASN,FKBP5,GBP2,GHRHR,HSD11B2,IRS1,NR5A2,OSMR,PTGS2,PTX3,SSTR4,TGFA,TGM1,TIMP1 | 483 (22) |
| GDF15 | 5.60e-01 | growth factor | NA | 1.18e+00 | 0.0e+00 | CDKN1A,PLAUR,PNPLA2,RND3,SERPINE1,TIMP3 | 511 (23) |
| ZC3H12A | 7.80e-01 | enzyme | NA | 1.18e+00 | 0.0e+00 | BCAR3,CCL2,Ccl2,CEBPD,DUSP1,EPGN,EREG,FOS,GBP4,GBP5,IL12B,IL1R2,IL21R,IL33,IL4R,JUNB,LAX1,LCN2,LIF,MMP9,P2RY10,POU2AF1,POU2F2,TNFRSF13C,TRIB1,ZC3H12D,ZFP36 | 410 (16) |
| THPO | NA | cytokine | NA | 1.17e+00 | 0.0e+00 | AURKB,BCL2L1,CMPK2,FOS,INHBA,ISG15,ITGA2B,KDR,MYC,MYCN,NFKBIA,RSAD2,SELP,SOCS3,SOX2,STAT1,USP18 | 450 (21) |
| CD40 | -6.00e-02 | transmembrane receptor | NA | 1.17e+00 | 0.0e+00 | ATF4,BCL2A1,BCL2L1,CCL17,CCL2,Ccl2,CCL4,CD22,CD27,CD40LG,CD69,CD83,CD8A,CDKN1A,CR2,CXCL10,CYSLTR1,DUSP1,EDEM1,ERN1,F3,FCER2,FOS,GZMB,HK2,HSH2D,IL12B,IL1A,IL24,IL2RB,IL4R,IL6R,IRF4,LGALS3,LTA,MAP3K6,MMP9,MYC,NFKBIA,ODC1,POU2AF1,PRF1,PTGS2,RASGRF1,RCL1,SELE,SELL,SERPINE1,SLC38A2,TBRG4,TBX21,TNFSF10,ZBTB16 | 421 (16) |
| LPAR1 | 6.60e-01 | G-protein coupled receptor | NA | 1.17e+00 | 0.0e+00 | F3,MMP9,PRKCG,PTGS2,SPHK1 | 405 (18) |
| TNFRSF12A | 1.22e+00 | transmembrane receptor | NA | 1.17e+00 | 0.0e+00 | BCL2L1,CCL2,Ccl2,CXCL10,TRIM63 | 354 (14) |
| 3-deazaneplanocin | NA | chemical drug | NA | 1.17e+00 | 0.0e+00 | ADORA2A,ANXA8/ANXA8L1,BCL2L1,CD274,CDKN1A,CLDN11,EXOC3L4,EZH2,KRT17,KRT7,MYC,NUPR1,TIMP3,TRIM14 | 448 (18) |
| ERBB2 | 2.70e-01 | kinase | NA | 1.17e+00 | 0.0e+00 | ABL1,ADAMTS5,AGR2,ANXA3,AR,ATF3,ATF4,BCL2L1,BHLHE40,BMP7,BTG2,C3AR1,CCL2,CCL4,CCR10,CCR3,CCR6,CDCA7,CDKN1A,CDON,CHST3,CLDN4,CNTN3,CX3CR1,CXCL10,CXCL3,CXCL6,CXCR4,DHH,DLL1,EDN1,Elf5,ELK3,ERBB3,EREG,F2RL1,F3,FASN,FOS,FSTL3,GALNT3,GFPT2,GLUL,GTF3A,H6PD,HEYL,IL1A,IL6R,JUNB,KDR,KRT7,KRT81,LCN2,LGALS3,LIF,LMO4,LPAR1,LTA,MAOA,MKNK2,MMP16,MMP9,MYC,MYCN,NEDD9,NFKBIA,NPC2,NPR3,NRP1,P4HA2,PDGFD,PDHA1,PDK4,PER1,PFKFB3,PLAT,PLAUR,PPP2R2B,PRIMA1,PTGS2,PTX3,S1PR5,SERPINE1,SLC7A1,SLC7A5,SOCS2,SPOCK1,STK17B,TCEAL9,TGFA,TGM1,THBS1,TIMP3,TNS4,WNT5A,XCR1,XDH,ZEB2 | 476 (19) |
| TGFB3 | -3.90e-01 | growth factor | NA | 1.17e+00 | 0.0e+00 | BHLHE40,CDH6,CDKN1A,CLDN11,COL2A1,F2RL1,FOS,FOSL2,MGP,MMP9,MS4A1,PLAUR,SERPINE1,TGFBR3,THBS1,TIMP3,ZEB2 | 611 (21) |
| PRKN | NA | enzyme | NA | 1.16e+00 | 0.0e+00 | CCL2,CDKN1A,CXCL2,EREG,FUBP1,IL1A,KDR,MAOA,MAOB,MMP9,MYC,PDHA1,PLAUR,SERPINE1 | 435 (18) |
| PLA2G10 | NA | enzyme | NA | 1.16e+00 | 4.0e-02 | CCL2,CCR9,CD8A,DYNLL1,KRT75,PTGS2,PTPRC,SLA2,SOAT1,TDRD5 | NA |
| NR2F2 | -5.80e-01 | ligand-dependent nuclear receptor | NA | 1.16e+00 | 0.0e+00 | CCL24,CCL28,HNF4A,IL33,KDR,NR5A2,NRP1,PCK1,PPARA,XCL1 | 263 (7) |
| IL10 | -2.00e-02 | cytokine | NA | 1.16e+00 | 0.0e+00 | ABCB1,APCS,ARG2,ARNT2,BCL2A1,BCL2L1,BMP2,BMP6,CA12,CCL17,CCL19,CCL2,Ccl2,CCL4,CCR6,CD14,CD163,CD274,CD28,CD83,CDKN1A,CIITA,CLCA1,CSF3R,CTSH,CTSV,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DUSP1,F3,FCER2,FKBP5,FOS,GZMA,GZMB,HMOX1,Igtp,IL12B,IL1A,IL1R2,IL24,IL33,IL4R,INHBA,ITGB7,KLRD1,LAG3,LIF,LTB,MAP3K8,MERTK,MMP8,MMP9,NEDD9,PTGS2,PTX3,RAB20,RGS16,S100A8,SELE,SELL,SHB,SLC11A1,SLC7A5,SNAP23,SOCS3,STAT1,TIMP1,TINAGL1,TLR5,TNFRSF13C,TNFSF10,XCL1,ZFP36 | 560 (18) |
| simvastatin | NA | chemical drug | NA | 1.16e+00 | 0.0e+00 | ADAMTS1,ADCYAP1R1,ANXA3,APOB,AR,BCL2L1,BMP2,CCL2,Ccl2,CD14,CD40LG,CDKN1A,CIITA,CRP,CXCL2,CXCL3,EDN1,ENC1,F3,FGA,FOS,GLI1,HMOX1,IL12B,LCN2,MAP1LC3B,MMP9,MYC,NFKBIA,PGLYRP1,PLAT,PON1,PPARA,PTGS2,SDC4,SELE,SELP,SERPINE1,SOAT1,SOCS3,STAT1,TIMP1 | 366 (14) |
| S1PR4 | -2.60e-01 | G-protein coupled receptor | NA | 1.16e+00 | 0.0e+00 | ADORA2B,AQP1,Ccl2,CCL28,CFAP54,CLDN5,CXCL2,F3,MOXD1,MRGPRF,SELP,ZNF354B | 330 (11) |
| NQO1 | 4.40e-01 | enzyme | NA | 1.15e+00 | 0.0e+00 | BCL2L1,CDKN1A,CSF3R,CXCR4,HK2,MMP9,PTGS2,SLC38A3,TP73 | 401 (17) |
| RELA | 4.00e-01 | transcription regulator | NA | 1.15e+00 | 0.0e+00 | ABCB1,ADAMTS5,ANKRD1,AR,BCL2A1,BCL2L1,BHLHE40,BMP2,BTG2,CBS/LOC102724560,CCL19,CCL2,Ccl2,CD14,CD274,CD28,CD69,CDKN1A,CIITA,COL2A1,CR2,CRP,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DIO2,DUSP1,EDN1,F3,FOS,GRK5,HMOX1,HNF4A,HSD11B2,ICA1,IER3,IKBKE,IL12B,IL1A,IRF4,ISG15,JUNB,LTA,LTB,MMP9,MYC,NFKBIA,OAS2,PCK1,PDGFB,Pmaip1,POU2AF1,PTGS2,PTX3,SDC4,SELE,SELP,SIX4,SLC2A5,STK17B,TBX21,TFPI2,TP73 | 460 (13) |
| Mapk | NA | group | NA | 1.15e+00 | 0.0e+00 | ABCB1,BCL2L1,CCL2,CCR9,CDKN1A,CLDN4,F3,FOS,GZMB,HMOX1,IRS1,ITGB7,JUNB,MMP9,MYC,PER1,PRF1,PTGS2,S100A8,SLC6A2,STAT1 | 405 (17) |
| cuprizone | NA | chemical toxicant | NA | 1.15e+00 | 1.0e-02 | ACER2,ACTC1,ANXA3,ASPA,Ccl2,CCL4,CXCL10,FOS,GLUL,LGALS3,PTGS2,PTPRC,RAMP3,SEMA7A,SOCS3,TGM1 | 255 (7) |
| formaldehyde | NA | chemical - endogenous mammalian | NA | 1.15e+00 | 0.0e+00 | FOS,FOSL1,FOSL2,HK2,JUNB,MMP9,NGFR,PFKFB3,PON1,PTGS2 | 401 (19) |
| NFYA | -9.80e-01 | transcription regulator | NA | 1.15e+00 | 1.0e-02 | ABCB1,ALB,CBS/LOC102724560,CDKN1A,FASN,GADD45A,GADD45B,JUNB,LPIN1,PCK1,TXNIP | 471 (12) |
| Ck2 alpha | NA | group | NA | 1.14e+00 | 0.0e+00 | BCL2L1,CXCL10,LTA,Mx2,MYC | 418 (22) |
| entinostat | NA | chemical drug | NA | 1.14e+00 | 0.0e+00 | ADAMTS5,BCL2L1,CD83,CDKN1A,CXCL10,DUSP1,ERBB3,LYVE1,MMP9,MYC,SERPINE1,TNFRSF19,TNFSF10 | 461 (17) |
| SYVN1 | 2.00e-02 | transporter | NA | 1.14e+00 | 0.0e+00 | ATP1A1,BHLHE40,DIO2,DUSP1,EPHA2,ERN1,F3,FANCG,FASN,IFI44,IFITM2,IRAK2,MCAM,PNPLA2,SLC39A10,SLC43A3,SLC6A6,SLC7A5,SNAP23,TNFRSF13C,TNS4,TRERF1 | 452 (12) |
| Ccl2 | 8.60e-01 | cytokine | NA | 1.14e+00 | 0.0e+00 | Ccl2,CCL4,CD14,CTSV,CXCL10,CXCL2,CXCL3,KDR,SDC4,SOX2 | 348 (14) |
| PLAT | 1.09e+00 | peptidase | NA | 1.14e+00 | 0.0e+00 | CXCL10,FOS,INHBA,MMP9,MYC,PLAT,PLG,SERPINE1 | 484 (19) |
| HBEGF | 3.40e-01 | growth factor | NA | 1.14e+00 | 0.0e+00 | AR,BHLHE40,BMP2,CXCR4,EREG,HK2,MMP9,NRP1,PDK4,PTGS2,SLC16A3,TGFA | 490 (19) |
| NR1I2 | -6.10e-01 | ligand-dependent nuclear receptor | NA | 1.14e+00 | 0.0e+00 | ABCB1,ABCC2,ADH1C,Ccl2,CCL24,CDKN1A,Ces1f,CPT1A,CXCL2,CXCL3,FASN,GLUL,HNF4A,IL12B,IL33,LCN2,MGP,NAT8B,NR0B2,PIPOX,POR,PPARA,S100A8,SLC22A7,SLCO1C1,SPHK1,TCN2,TNFRSF14 | 567 (19) |
| PLK2 | 2.60e-01 | kinase | NA | 1.13e+00 | 0.0e+00 | CMPK2,CXCL10,EDN1,MERTK,Mx2,PLAT,RGCC | NA |
| GPR15LG | NA | cytokine | NA | 1.13e+00 | 1.0e-02 | CIITA,IFIT1,IL24,MAFF,S100A8,SOCS3,TGM1 | NA |
| daporinad | NA | chemical drug | NA | 1.13e+00 | 1.0e-02 | BHLHE40,CCL2,CD274,IL12B,LIF,SERPINE1,SOX2 | 496 (18) |
| acyclic retinoid | NA | chemical drug | NA | 1.13e+00 | 0.0e+00 | CDKN1A,KDR,MYC,MYCN,XPO1 | 419 (21) |
| iron dextran | NA | chemical drug | NA | 1.13e+00 | 0.0e+00 | BMP6,Ccl2,HNF4A,NFKBIA | NA |
| MECOM | NA | transcription regulator | NA | 1.13e+00 | 1.0e-02 | BCL2L1,CDKN1A,GADD45G,ITGA2B,SERPINE1,ZFPM2 | NA |
| ethoxyquin | NA | chemical toxicant | NA | 1.13e+00 | 2.0e-02 | GCLC,Gsta1,Slco1a1,TRPC3 | NA |
| ZBTB18 | NA | transcription regulator | NA | 1.13e+00 | 4.0e-02 | ADGRE5,C1QTNF1,SERPINH1,TRIL | NA |
| TRH | 1.60e+00 | other | NA | 1.13e+00 | 0.0e+00 | DIO2,DUSP1,FOS,JUNB,KCNA5,SFTPB,TRH | 560 (27) |
| KRAS | 4.00e-02 | enzyme | NA | 1.13e+00 | 0.0e+00 | ADAMTS1,ADAMTS5,ANXA8/ANXA8L1,ARG2,ATF3,ATP1B1,AURKB,BCL2A1,BCL2L1,BMP6,CCL2,Ccl2,CD274,CDKN1A,CHST3,CLEC10A,CNTN3,CPT1B,CSF3R,CXCL10,CXCL6,CXCR4,DUSP1,EDEM1,EPHA2,EREG,EZH2,F2RL1,F3,FASN,FOS,FOSL1,GADD45A,GALNT10,GALNT3,GCLC,GLI1,GLUL,HK2,HMOX1,IER3,IFIT1,IFITM2,IL1A,IL24,IL33,ISG15,JUNB,LAMA5,LCN2,LGALS3,LGI3,LIF,LOX,MACC1,MAP1LC3B,MCAM,MLC1,MMD,MMP9,MUC13,MX1,MYC,MYCN,NFKBIA,NGFR,NR5A2,NRN1,NUDT5,Oasl2,ODC1,P2RY14,PECR,PLA1A,PLAT,PLCD1,POR,PTGS2,PTPRC,PTX3,RAB20,RCL1,RUNX1T1,SDC4,SEMA7A,SERPINE1,SFTPB,SLC43A3,SLC7A1,SMPD3,SOAT1,SOCS3,SOX2,STAT1,TBX21,TESC,TGFA,THBS1,TIMP3,TINAGL1,TLE3,TNFRSF12A,TNFSF10,TRIB1,TXNIP,UPP1,VSTM5,ZFAND2A | 420 (17) |
| sulindac | NA | chemical drug | NA | 1.13e+00 | 1.0e-02 | ABCB1,CDKN1A,ERBB3,G0S2,GCLC,MYC,MYCN,PTGS2,SERPINB1 | 537 (23) |
| BMP10 | 1.00e-02 | growth factor | NA | 1.12e+00 | 0.0e+00 | AQP1,Ccl2,CD274,CD83,CMPK2,CX3CR1,FOS,GLI1,GRHL1,HAS1,LCN2,NFKBIA,RSAD2,SELE,THBS1,TIMP1 | 351 (10) |
| 1,1-bis(3’-indolyl)-1-(4-trifluoromethyl-phenyl)methane | NA | chemical reagent | NA | 1.12e+00 | 0.0e+00 | AR,ATF3,CDKN1A,TNFSF10 | 269 (7) |
| 5-N-ethylcarboxamido adenosine | NA | chemical reagent | NA | 1.11e+00 | 0.0e+00 | ADORA2A,ADORA2B,ALB,ARG2,BHLHE40,BTG2,CCL2,Ccl2,CEBPD,CIITA,CREM,GADD45A,GCLC,GNRH1,HK2,HMOX1,IL12B,INHBA,JUNB,KCNA2,NFIL3,NRP1,ODC1,PROCR,SERPINE1,SOCS3,SOX2,THBS1,TXNIP,UBC | 491 (16) |
| MAOA | -6.00e-01 | enzyme | NA | 1.11e+00 | 4.0e-02 | CCL2,CEBPD,IL1A,MYC,SOCS3 | NA |
| LMNA | -4.70e-01 | other | NA | 1.10e+00 | 0.0e+00 | ACKR4,ADAMTS10,CAMK1D,CD28,CDH15,CERS6,CPT1B,DNAJB12,EDN1,ERN1,GCLC,GULP1,HAS3,IFI44,Irgm1,KLF15,MAFF,MAP3K8,MCAM,MMP9,MYC,Nes,PNPLA2,PPARA,PPARGC1B,SEMA7A,SLC25A42,SLC38A2,STAT1,TIMP3,UBA7,ZFP36,ZNF397,ZNF519 | 541 (22) |
| aplidine | NA | biologic drug | NA | 1.10e+00 | 0.0e+00 | DUSP1,FOS,FOSL1,JUNB | 376 (18) |
| CHEK2 | 7.00e-02 | kinase | NA | 1.10e+00 | 0.0e+00 | BCL2L1,CDKN1A,Pmaip1,TP53BP2,TP73 | 397 (17) |
| spermine | NA | chemical - endogenous mammalian | NA | 1.10e+00 | 1.0e-02 | CCL2,CCL4,ODC1,SAT1 | 280 (11) |
| PDGFRA | 4.00e-02 | kinase | NA | 1.10e+00 | 1.0e-02 | CDKN1A,EZH2,FOS,MYC | NA |
| DLX2 | 2.00e-02 | transcription regulator | NA | 1.10e+00 | 2.0e-02 | BMPER,CDKN1A,MYC,TELO2 | NA |
| EWSR1 | NA | other | NA | 1.10e+00 | 5.0e-02 | ABL1,F2RL1,FOS,PBK,PCDH20 | NA |
| GDF9 | NA | growth factor | NA | 1.10e+00 | 2.0e-02 | HAS1,INHBA,LOX,PTGS2,PTX3,TNFAIP6 | NA |
| Pkc(s) | NA | group | NA | 1.10e+00 | 0.0e+00 | AQP3,ARG2,ATF3,BCL11B,BCL2L1,CCL2,CDKN1A,CPT1A,CXCR4,DUSP1,EDN1,ERN1,F3,FGFBP1,FOS,FOSL1,GADD45A,GADD45B,GNRH1,HMOX1,IAPP,IL12B,IRS1,JUNB,MAOB,MMP9,MS4A1,PER1,PON1,POU2F2,PPARA,PTGS2,PTPRN,S100A8,SERPINE1,SLC6A2,TGM1,TP73 | 500 (21) |
| ADRB3 | -2.60e-01 | G-protein coupled receptor | NA | 1.09e+00 | 0.0e+00 | CCL2,Ccl2,DIO2,FOS,JUNB,PTGS2 | 418 (21) |
| trichostatin A | NA | chemical drug | NA | 1.09e+00 | 0.0e+00 | ABCB1,ABCC2,ACOX2,ADAMTS1,ADAMTS5,ADGRE1,ADGRL2,ANKRD1,AR,AURKB,BAIAP2,BCL11A,BCL2A1,BCL2L1,BMP2,CA12,CAP2,CCL2,Ccl2,CCNA1,CCR3,CD14,CD28,CD40LG,CD79B,CDCA7,CDKN1A,CIITA,COL2A1,CREB1,CREM,CSF3R,CXCL10,CXCL2,CXCL3,CXCR4,CYP46A1,DKK2,DNASE1L3,DOK2,DUSP1,EREG,F3,FASN,FGFR4,FLRT3,FOS,FOSL2,FOXC1,FTL,FUBP1,GADD45A,GADD45G,GCLC,GNAI2,HMOX1,HSD11B2,IGSF9,IL12B,IL1A,IL24,IRF4,KDR,LOX,MAP1LC3B,MMP9,MS4A1,MYC,MYCN,Nes,NFKBIA,NGFR,NME5,NR0B2,NRP1,OGT,PAX5,PCDH20,PLAUR,PNPLA2,PPARA,PPARGC1B,PSAT1,PTGS2,RASSF1,RCL1,RERG,RND3,SAT1,SELE,SERPINE1,SEZ6L,SLC43A1,SLC5A1,SLC7A1,SMO,SPHK1,SPN,SPOCK1,STEAP2,SYT1,TFPI2,TGM1,THBS1,TIMP1,TIMP3,TNFSF10,TXNIP,TXNRD1,WNT5A,XCL1,XPO1 | 480 (18) |
| lipoarabinomannan | NA | chemical - endogenous non-mammalian | NA | 1.09e+00 | 0.0e+00 | CCL4,CD14,CXCL2,CXCR4,ERBB3,IER3,ITGA7,SELE,STAT1 | 468 (16) |
| ZEB2 | -6.10e-01 | transcription regulator | NA | 1.09e+00 | 2.0e-02 | CDKN1A,CX3CR1,FCN1,GAB2,GZMA,ID4,MEOX2,MYC,SELL | NA |
| PDCD1 | 1.30e-01 | transmembrane receptor | NA | 1.09e+00 | 2.0e-02 | CBLB,CD8A,FAR2,GZMA,GZMB,IL33,SLC7A5,STAT1,TBX21 | NA |
| MAPK9 | 1.30e-01 | kinase | NA | 1.09e+00 | 0.0e+00 | ABCB11,AQP1,BAAT,CCL2,Ccl2,CDKN1A,DIO2,DLK1,EDN1,F3,FASN,FOS,FOSL1,FOSL2,GADD45A,GADD45B,HDC,IL12B,JUNB,LIF,LTA,MMP9,MUC5B,MYC,PLA1A,PLAT,PPARA,PTX3,RILPL1,TBX21,TNFSF8,ZFP36 | 448 (14) |
| DMRT1 | NA | transcription regulator | NA | 1.09e+00 | 2.0e-02 | AR,AU015836,CLDN11,CLEC12B,DMRT2,MAP2K6,MAPKAPK3,Meis1,MMP16,P4HA1,SOX2 | NA |
| GNA11 | -3.00e-02 | enzyme | NA | 1.09e+00 | 2.0e-02 | ADAMTS1,CTSV,EGR3,KLF15 | NA |
| SIRT1 | 2.50e-01 | transcription regulator | NA | 1.09e+00 | 0.0e+00 | ABCB1,ABCC2,Acan,ACAP1,ADAMTS5,ARNT2,AURKB,BCL2L1,CA12,Ccl2,CD79B,CD83,CDKN1A,CLCA1,CLEC10A,CMPK2,COL2A1,CPT1A,CPT1B,CREB1,Csprs (includes others),EDEM1,FASN,FBXO39,FCMR,GABARAPL1,GADD45A,GATA5,GLI1,HK2,HMOX1,IFI44,Igtp,IL12B,Irgm1,LCK,LGALS3,MAOA,MMP9,MYC,NECTIN4,NEDD4L,NELL2,OAS2,Oasl2,PCK1,PDK4,PER1,Pmaip1,PNPLA3,RGS16,RNF213,RNF39,RSAD2,SERPINE1,SLC43A3,SOCS3,SSBP3,STAT1,TBC1D8,TIMP3,TMPRSS4,TP73,TRIM63,UBA7,USP18 | 504 (25) |
| brefeldin A | NA | chemical - endogenous non-mammalian | NA | 1.09e+00 | 1.0e-02 | CHRNA7,CXCL3,GADD45B,HMOX1,PTGS2,SESN2,THBS1,TIMP1 | NA |
| IL11 | 1.40e-01 | cytokine | NA | 1.09e+00 | 0.0e+00 | BCL2A1,BCL2L1,CEBPD,COL2A1,CRP,DLK1,FOS,JUNB,MMP9,SFTPB,SOCS3,SPHK1,TIMP1,WNT5A | 353 (15) |
| DKK1 | NA | growth factor | NA | 1.08e+00 | 1.0e-02 | BMP6,CDKN1A,F2RL1,HNF4A,MMP9,MYC,PTGS2,WNT11,WNT5A,WNT7A | 482 (22) |
| ASCL1 | -2.70e-01 | transcription regulator | NA | 1.08e+00 | 1.0e-02 | CDCA7,CDKN1A,CIITA,DLL1,EPHA2,GADD45G,SEMA6B,SEMA7A,SEZ6,SOX2,SYT6,THRB | NA |
| bardoxolone | NA | chemical drug | NA | 1.08e+00 | 0.0e+00 | BCL2L1,CDKN1A,GCLC,HMOX1,IRS1,NFKBIA,TXNRD1 | 437 (18) |
| E. coli B5 lipopolysaccharide | NA | chemical - endogenous non-mammalian | NA | 1.07e+00 | 0.0e+00 | ADAMTS1,ADH1C,ADORA2B,BHLHE40,CCL17,CCL19,CCL2,Ccl2,CCL24,CCL4,CCR10,CCR6,CCR9,CD274,CD69,CD83,CDKN1A,CIDEA,CSF3R,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DUSP1,ERRFI1,F3,FASN,FOS,GBP2,GCLC,HMOX1,IFIT1,Igtp,IL12B,IL1A,IL1R2,IL21R,IL6R,JUNB,LIF,MAP3K8,NEDD4L,NFKBIA,PAX5,PTGS2,SELE,SELENBP1,SERPINE1,SOCS2,SOCS3,TGFBR3,THBS1,XCL1,XCR1 | 406 (15) |
| SLC2A1 | 3.60e-01 | transporter | NA | 1.07e+00 | 2.0e-02 | HMOX1,MYC,PPARA,PTGS2,SERPINE1 | NA |
| ATF1 | 2.70e-01 | transcription regulator | NA | 1.07e+00 | 0.0e+00 | ATP1A1,CD79A,CIITA,CREB1,FOS,FOSL1,HMOX1,INHBA,MUC5B,PTGS2,THBS1 | 237 (7) |
| EDNRA | -7.40e-01 | transmembrane receptor | NA | 1.07e+00 | 0.0e+00 | ECE1,FOS,PTGS2,SELL,TIMP1 | 329 (18) |
| SPP1 | 3.10e-01 | cytokine | NA | 1.07e+00 | 0.0e+00 | BCL2L1,CCL2,Ccl2,CCL4,CD163,CD40LG,CDKN1A,CXCL2,CXCL3,CXCL6,FOS,HMOX1,IL12B,IL1A,LIF,LOX,MMP9,MYC,POR,PTGS2,SERPINE1,TIMP1 | 417 (16) |
| Foxo | NA | group | NA | 1.07e+00 | 0.0e+00 | ABCB1,ABCC2,CDKN1A,GADD45A,TRIM63 | 364 (7) |
| hydroquinone | NA | chemical - endogenous mammalian | NA | 1.07e+00 | 0.0e+00 | FOS,GCLC,HK2,HMOX1,SFN | 403 (17) |
| meclizine | NA | chemical drug | NA | 1.07e+00 | 1.0e-02 | ABCC2,HK2,IL1A,MYC | 98 (4) |
| OCLN | 3.40e-01 | other | NA | 1.07e+00 | 1.0e-02 | CCL2,CCL4,CXCL10,MMP9 | 224 (7) |
| GPR37 | -7.80e-01 | G-protein coupled receptor | NA | 1.07e+00 | 1.0e-02 | AR,Ccl2,DHH,MAP1LC3B | NA |
| USP1 | 1.30e-01 | peptidase | NA | 1.07e+00 | 1.0e-02 | BMP6,CLDN4,PGF,TIMP1 | NA |
| FGFR | NA | group | NA | 1.07e+00 | 2.0e-02 | BCL2L1,FOS,HMOX1,SOX2 | NA |
| KT5823 | NA | chemical - kinase inhibitor | NA | 1.07e+00 | 2.0e-02 | EDN1,FOS,PLAUR,RYR2 | NA |
| tert-butyl hydroperoxide | NA | chemical toxicant | NA | 1.07e+00 | 3.0e-02 | BCL2L1,COL2A1,Pmaip1,PTGS2 | NA |
| CRHR2 | -3.10e-01 | G-protein coupled receptor | NA | 1.07e+00 | 3.0e-02 | Ccl2,CXCL2,KCNMB1,RBP4 | NA |
| Tnf receptor | NA | group | NA | 1.07e+00 | 4.0e-02 | MMP9,SELE,SERPINE1,TIMP1 | NA |
| arecoline | NA | chemical drug | NA | 1.07e+00 | 4.0e-02 | BCL2L1,HMOX1,MAOA,PGF | NA |
| EGR1 | 5.80e-01 | transcription regulator | NA | 1.06e+00 | 0.0e+00 | ABCB1,AR,ATF3,BAIAP2,CCL2,Ccl2,CCL4,CD40LG,CDKN1A,CHRNA7,COL2A1,CREM,CXCL2,CXCL3,CXCL6,EREG,EZH2,F3,FOSL1,FTL,GADD45A,GADD45B,GALNT3,GLI1,HMOX1,IL6R,JUNB,KCNT1,MAOB,MAP1LC3B,MMP9,MYC,PNPLA2,PTGS2,SERPINE1,THBS1,TIMP1,TNFSF10,TP73 | 411 (17) |
| reactive oxygen species | NA | chemical toxicant | NA | 1.06e+00 | 0.0e+00 | BCL2L1,CCL2,CDKN1A,CXCR4,EDN1,ERBB3,F3,GADD45A,GZMB,HMOX1,LPIN1,MYC,PRF1,PTGS2,SERPINE1,TP73,TRPV1 | 428 (19) |
| ID2 | 1.80e-01 | transcription regulator | NA | 1.06e+00 | 0.0e+00 | AURKB,BCL2L1,BMP7,BTG2,CCR10,CCR9,CD19,CD27,CD40LG,CD79A,CD83,CDKN1A,CXCR4,DLL1,DUSP1,GADD45B,GADD45G,GFI1,IKZF3,IL2RB,IL4R,IL6R,IRF4,LMO4,LTA,LTB,MAP2K6,MCAM,MYC,NGFR,PIK3C2B,PIK3IP1,POU2F2,RAPGEF4,SELL,SLAMF6,SOCS3,TGFBR3,TNFRSF19,TNFSF10,TNFSF8,WNT11,ZBTB16 | 488 (25) |
| D-galactosamine | NA | chemical - endogenous mammalian | NA | 1.06e+00 | 0.0e+00 | ALB,CD14,CXCL10,CXCL2,EDNRA,FOS,IL12B,IL33,JUNB,MYC,NFKBIA,PTGS2,TIMP1,TNFSF10 | 441 (12) |
| C5AR1 | 3.00e-02 | G-protein coupled receptor | NA | 1.05e+00 | 1.0e-02 | Ccl2,CD28,CXCL2,CXCL3,ERN1,IL12B,MMP9,SELP,SERPINE1 | 257 (15) |
| raloxifene | NA | chemical drug | NA | 1.05e+00 | 0.0e+00 | ANXA3,BMP2,CDKN1A,CTSH,CXCL6,DDIT4,DUSP1,DYNLL1,EDN3,EGR3,ERBB3,GNRH1,HMOX1,IER3,KRT7,KRT81,KYNU,MMD,PAX5,PPP1R3C,PTGER3,PTGS2,SELENBP1,SERPINE1,TGFA,TIMP1,TIMP3 | 538 (22) |
| Collagen Alpha1 | NA | group | NA | 1.05e+00 | 1.0e-02 | CDKN1A,MMP9,PLAUR,PTGS2 | 414 (18) |
| IL24 | 1.93e+00 | cytokine | NA | 1.04e+00 | 0.0e+00 | BCL2L1,Ccl2,GADD45A,GADD45G,IL12B,IL24,IRF4,PAX5,PTGS2 | 373 (16) |
| IL10RA | -1.60e-01 | transmembrane receptor | NA | 1.04e+00 | 0.0e+00 | ABCB1,ADGRL2,ADH1C,AOC1,ARG2,BMP2,CBS/LOC102724560,CD69,Ces2g,CSF3R,CYP2S1,DDIT4,EDN1,F10,FERMT1,GBP2,GBP5,H2-T22,HMCN1,IKBKE,IL12B,IL1A,INHBA,Irgm1,ITGB7,Klrk1,LCN2,LGALS12,LMO4,MAOB,NR5A2,PCK1,PROCR,RGS18,RNF213,RSAD2,SCIN,SELENBP1,SELL,Siglech,SLAMF6,SLC16A3,SOCS3,STAT1,TNFRSF14,TREM3,TRPM2,UPP1,ZBP1 | 300 (14) |
| LUCAT1 | NA | other | NA | 1.04e+00 | 0.0e+00 | CDKN1A,CLDN4,ERBB3,FGA,IER3,PDK4,PTGS2,SAT1 | NA |
| Bay 11-7082 | NA | chemical - kinase inhibitor | NA | 1.03e+00 | 0.0e+00 | ADORA2A,BCL2A1,BCL2L1,CCL2,Ccl2,CCL4,CD274,CD83,CREB3L3,CXCL2,CXCL3,F3,HMOX1,HSH2D,IL2RB,MMP9,PON1,PTGS2,SIX4,TNFSF10 | 394 (12) |
| NOS3 | 3.80e-01 | enzyme | NA | 1.03e+00 | 0.0e+00 | ADGRE1,ATF3,BMP2,CCL2,Ccl2,CXCL3,F3,IL12B,PTGS2 | 325 (15) |
| UTP | NA | chemical - endogenous mammalian | NA | 1.03e+00 | 0.0e+00 | CCL2,Ccl2,CD14,F3,LTA,SERPINE1,THBS1 | 440 (19) |
| CD38 | -3.50e-01 | enzyme | NA | 1.03e+00 | 0.0e+00 | ATP1B1,CD40LG,CRELD2,GADD45G,GBP2,GBP4,GBP7,IL1R2,IL6R,ITGB7,LGALS3,LTA,NFIL3,P4HA1,PAX5,PPARA,PSAT1,SELL,SLC16A3,SLC7A5,SOCS2,SOCS3,UCK2 | 460 (15) |
| Fgf | NA | group | NA | 1.03e+00 | 0.0e+00 | FOS,JUNB,KDR,MMP9,ODC1,PER1,PTGS2,STAT1 | 431 (20) |
| PDX1 | NA | transcription regulator | NA | 1.02e+00 | 0.0e+00 | ALB,ARL4D,ATF3,ATF4,Ccl2,CDO1,CKMT1A/CKMT1B,CRELD2,CREM,CXCL2,CXCR4,DLK1,F3,HNF4A,IAPP,IER3,JUNB,KCNJ11,MAOB,Mt1,MYC,NR5A2,Pmaip1,PTGER3,RSAD2,SEZ6L,SLC6A6,SSBP3,TGFBR3,TRPC3,TXNIP | 503 (20) |
| platelet activating factor | NA | chemical - endogenous mammalian | NA | 1.02e+00 | 0.0e+00 | CCL2,CD69,CDKN1A,F3,FOS,IL1A,MMP8,MMP9,NFKBIA,PLAUR,PTGS2,SELL,SELP,SERPINE1,SOCS3,THBS1,TIMP1 | 466 (15) |
| CRH | NA | cytokine | NA | 1.02e+00 | 1.0e-02 | AR,CXCL6,DIO2,EDN1,FOS,GNRH1,JUNB,KCNMB1,PTGS2,SOCS3 | 412 (18) |
| SP3 | -1.40e-01 | transcription regulator | NA | 1.02e+00 | 0.0e+00 | ABCB1,ATF3,CBS/LOC102724560,Ccl2,CDKN1A,COL2A1,CYP46A1,CYP7B1,DUSP1,EREG,F10,F3,FOS,FOSL1,GNAI2,HSD11B2,IFITM5,IL1A,IL2RB,ITGAD,KDR,KRT81,MAOB,MYCN,NR5A2,PEMT,PLAUR,PROCR,PTGS2,SERPINE1,SERPINH1,STAT1,TGFBR3,TGM1,TIMP1,TXNRD1 | 541 (21) |
| IL2RG | -3.80e-01 | transmembrane receptor | NA | 1.02e+00 | 0.0e+00 | ARMCX2,CXCL10,CXXC5,FOS,IKBKE,ISG15,LTB,MYC,NEDD4L,NPC2,SESN1,STAT1,UBA7 | 358 (17) |
| MAP2K7 | 2.00e-01 | kinase | NA | 1.02e+00 | 0.0e+00 | ATF3,CDKN1A,CXCL10,JUNB,MAOB,MUC5B,MYC,SERPINC1,TFPI2 | 408 (17) |
| ISG15 | -7.10e-01 | other | NA | 1.02e+00 | 4.0e-02 | FMO3,GCLC,IFIT1,MX1,TIMP1,USP18 | NA |
| MAPK14 | 1.70e-01 | kinase | NA | 1.01e+00 | 0.0e+00 | ANKRD1,ATF3,ATP2B4,BMP2,BTG2,CCL2,Ccl2,CD83,CEBPD,CRP,CXCL10,CXCL2,CXCL3,CXCL6,DLL1,DUSP1,EREG,F3,FASN,FGFBP1,FOS,FOSL2,GADD45A,HMOX1,IL12B,JUNB,KDR,MAOB,MAP2K6,MMP9,MUC5B,NGFR,NRP1,PCK1,PLAUR,Pmaip1,PPARGC1B,PTGS2,S100A8,SOCS3,SOX2,SPHK1,TBX21,TIMP1,TRPA1,TRPV1,ZFP36 | 520 (17) |
| PHLPP1 | -1.30e-01 | enzyme | NA | 1.01e+00 | 0.0e+00 | CEBPD,CTHRC1,CXCL2,CXCL3,IRS1,MAP1LC3B,PRKCB | 378 (14) |
| ACVR1C | -5.90e-01 | kinase | NA | 1.01e+00 | 1.0e-02 | BCL2L1,CDKN1A,FOS,JUNB,SERPINE1 | 501 (21) |
| NS-398 | NA | chemical reagent | NA | 1.01e+00 | 3.0e-02 | BMP2,BTG2,CDKN1A,CXCR4,F3,IL1A,IL24,MMP9,PTGS2,S100A8,TFPI2 | NA |
| CERS2 | 4.80e-01 | transcription regulator | NA | 1.00e+00 | 0.0e+00 | ABCB1,CDKN1A,CERS6,SMPD3 | 195 (3) |
| gingerenone A | NA | chemical - endogenous non-mammalian | NA | 1.00e+00 | 0.0e+00 | ANKRD1,CDKN1A,EDN1,SERPINE1 | NA |
| A939572 | NA | chemical reagent | NA | 1.00e+00 | 0.0e+00 | ATF4,G0S2,LCN2,PNPLA2 | NA |
| puromycin | NA | chemical - endogenous non-mammalian | NA | 1.00e+00 | 0.0e+00 | BCL2L1,F3,GHRHR,RBM3,SERPINE1,XPO1 | 360 (17) |
| allyl isothiocyanate | NA | chemical toxicant | NA | 1.00e+00 | 0.0e+00 | BCL2L1,FOS,HMOX1,MMP9,PTGS2 | 453 (20) |
| C8 | NA | complex | NA | 1.00e+00 | 0.0e+00 | Ccl2,CXCL2,CXCL3,SELE | 304 (10) |
| C7 | 6.00e-02 | other | NA | 1.00e+00 | 0.0e+00 | Ccl2,CXCL2,CXCL3,SELE | 304 (10) |
| RPS6KB2 | 4.10e-01 | kinase | NA | 1.00e+00 | 0.0e+00 | BCL2L1,CXCL10,IRS1,ISG15 | NA |
| decursin | NA | chemical - endogenous non-mammalian | NA | 1.00e+00 | 0.0e+00 | CDKN1A,FASN,KDR,MMP9,MYC | 462 (21) |
| HNRNPU | -4.80e-01 | transporter | NA | 1.00e+00 | 0.0e+00 | CCL2,CD5L,CTSV,CYP26B1,DACH1,LRTM2,MYC,Oasl2,OSR1,PDGFD | NA |
| C9 | -7.70e-01 | other | NA | 1.00e+00 | 0.0e+00 | Ccl2,CXCL2,CXCL3,SELE | 304 (10) |
| TCF20 | -2.00e-02 | transcription regulator | NA | 1.00e+00 | 0.0e+00 | GALNT15,HCRTR1,MMD,MYC,NEXN,PPP3R1,PRKCG,SCN4B,TP53BP2,TXNIP | NA |
| CYBB | -2.20e-01 | enzyme | NA | 1.00e+00 | 0.0e+00 | CCL2,Ccl2,CDKN1A,CXCL10,CXCL3,DUSP1,PTGS2 | 418 (16) |
| IGFBP7 | 2.50e-01 | transporter | NA | 1.00e+00 | 1.0e-02 | CDKN1A,MMP9,MYC,PTGS2 | 443 (20) |
| IL18R1 | -1.80e-01 | transmembrane receptor | NA | 1.00e+00 | 1.0e-02 | CD40LG,IL1A,SOCS3,STAT1 | 428 (18) |
| LMO2 | -5.10e-01 | transcription regulator | NA | 1.00e+00 | 1.0e-02 | ACOX2,ADAMTS9,BCL11A,BMP7,CD3G,CD79B,CDKN1A,CLDN4,DAB2IP,DLK1,EPB42,GBP5,ITGB7,LCK,LPIN2,MAP3K8,NPRL3,Oasl2,RASGRP1,SLC16A5,SLC43A1,TBX21,TMEM38B,TNFRSF8,TXNIP,WNK2 | 105 (5) |
| SOST | NA | other | NA | 1.00e+00 | 1.0e-02 | Ccl2,CCL4,CPT1A,FASN,NKD2,PPARA | 391 (11) |
| TNFAIP2 | -4.00e-02 | other | NA | 1.00e+00 | 1.0e-02 | LTA,MERTK,PLAT,RILPL1 | NA |
| MAFG | 2.20e-01 | transcription regulator | NA | 1.00e+00 | 1.0e-02 | GCLC,HMOX1,ITGA2B,TNFSF18,TXNRD1 | NA |
| LDB1 | 3.80e-01 | transcription regulator | NA | 1.00e+00 | 1.0e-02 | ACOX2,ADAMTS9,BCL11A,BMP7,CD3G,CD79B,CDKN1A,CLDN4,DAB2IP,DLK1,EPB42,GBP5,ITGB7,LCK,LPIN2,MAP3K8,NPRL3,Oasl2,RASGRP1,SLC16A5,SLC43A1,TBX21,TMEM38B,TNFRSF8,TXNIP,WNK2 | NA |
| ZC3H14 | -8.00e-02 | other | NA | 1.00e+00 | 1.0e-02 | LTA,MERTK,PLAT,RILPL1 | NA |
| PSMB8 | -4.80e-01 | peptidase | NA | 1.00e+00 | 1.0e-02 | IL1A,IRS1,NFKBIA,PTGS2 | NA |
| P2RX4 | 2.90e-01 | ion channel | NA | 1.00e+00 | 1.0e-02 | Ccl2,CXCL2,CXCL3,MMP9 | NA |
| VGLL3 | -9.70e-01 | other | NA | 1.00e+00 | 1.0e-02 | ANKRD1,GADD45B,OSR2,THBS1 | NA |
| MUC4 | NA | other | NA | 1.00e+00 | 2.0e-02 | CDKN1A,ERBB3,MMP9,PRKCG | NA |
| acetyl-L-carnitine | NA | chemical - endogenous mammalian | NA | 1.00e+00 | 2.0e-02 | CDKN1A,CPT1A,GADD45A,PPARA | NA |
| TEK | 4.00e-02 | kinase | NA | 1.00e+00 | 2.0e-02 | CDKN1A,CLDN5,IL1A,S100A8 | NA |
| BID | 1.40e-01 | other | NA | 1.00e+00 | 2.0e-02 | C3AR1,Ccl2,CTSH,TIMP1 | NA |
| SN-38 | NA | biologic drug | NA | 1.00e+00 | 2.0e-02 | BCL2L1,BMP6,CDKN1A,HK2,IL1A,MYC | NA |
| proteasome inhibitor PSI | NA | chemical - protease inhibitor | NA | 1.00e+00 | 2.0e-02 | BMP2,Ccl2,CCL4,CXCL2,HMOX1 | NA |
| EIF4G2 | -4.00e-02 | translation regulator | NA | 1.00e+00 | 3.0e-02 | CDKN1A,PLAT,PTGS2,SOX2 | NA |
| IL15RA | -1.50e-01 | transmembrane receptor | NA | 1.00e+00 | 3.0e-02 | CD84,EDN1,PTPRC,SPN | NA |
| mocetinostat | NA | chemical drug | NA | 1.00e+00 | 4.0e-02 | CXCL10,MMP9,NGFR,SERPINE1 | NA |
| TOX | 1.80e-01 | transcription regulator | NA | 1.00e+00 | 4.0e-02 | CD27,EGR3,NFIL3,TNFRSF8 | NA |
| green tea polyphenol | NA | chemical drug | NA | 1.00e+00 | 4.0e-02 | CDKN1A,FOS,HMOX1,MMP9,PTGS2 | NA |
| BAHCC1 | -4.60e-01 | other | NA | 1.00e+00 | 5.0e-02 | CDKN1A,IKZF3,SHOX2,SIX4 | NA |
| CDKN1A | 2.14e+00 | kinase | NA | 1.00e+00 | 0.0e+00 | AURKB,BCL2L1,CCL2,CD274,CDKN1A,CXCL2,CXCL3,DUSP1,EDNRA,F9,FANCG,FAT2,FRAS1,GADD45A,INHBA,LGALS3,MMP9,MYC,NFKBIA,NRP1,OSMR,P4HA1,PBK,Pmaip1,PRF1,PRSS22,PTPRC,SERPINE1,TCN2,TGFA,TGM1,THBS1,TNFAIP6,TNFRSF18,TUBG2 | 512 (20) |
| 32-134D | NA | chemical reagent | NA | 1.00e+00 | 0.0e+00 | BMP6,CCL19,CCL2,CD274,CD40LG,CXCL10,CXCL2,CXCL3,IL12B,IL24,LTA,PGF | NA |
| PTGER4 | -1.00e-02 | G-protein coupled receptor | NA | 1.00e+00 | 0.0e+00 | ADAMTS4,ARRDC3,CCL2,Ccl2,CCL4,CD69,CMPK2,CREB3L3,CXCL10,CXCR4,EDN1,GBP2,GBP4,Igtp,IL12B,Irgm1,MAFF,MMP9,Mx2,PDGFB,PTGER3,PTGS2,RNF213,RSAD2,SLC13A3,STXBP4,TNFSF10,USP18 | 508 (17) |
| PRKD1 | 5.00e-02 | kinase | NA | 1.00e+00 | 0.0e+00 | Ccl2,CCL4,CXCL10,CXCL2,CXCL3,CXCL6,ERN1,F3,IL12B,KDR,MMP9 | 299 (19) |
| MYD88 | 5.10e-01 | other | NA | 9.90e-01 | 0.0e+00 | ABCB1,APCS,ATF4,CCL17,CCL2,Ccl2,CCL4,CD14,CD274,CD83,CEBPD,CLEC10A,CMPK2,CREB3L3,CXCL10,CXCL2,CXCL3,CXCL6,DUSP1,FOS,GZMB,HDC,HMOX1,IKBKE,IL12B,IL1A,INHBA,IRAK2,ISG15,ITGB7,LPAR1,LTA,LTB,MAFF,MMP8,MMP9,MYC,Nes,NFKBIA,PRF1,PTGS2,RSAD2,S100A8,SELE,SERPINE1,SLC16A3,SOCS3,TBX21,TIMP1,TNFRSF12A,Tnfsf9,TRIM63,USP18,XDH,ZC3H12A | 426 (16) |
| Nr1h | NA | group | NA | 9.90e-01 | 0.0e+00 | ANGPTL3,AQP3,ARG2,ARNT2,ATP1B1,BMP6,CCL2,Ccl2,CD5L,CXCL10,ECE1,EDN1,EDNRA,FASN,GLI1,H6PD,HLA-DOB,IL12B,LAT2,LTB,MERTK,Mx2,NR5A2,PTGS2,RGN,SELP,THBS1,TIMP3,ZBTB16 | 445 (21) |
| oxazolone | NA | chemical reagent | NA | 9.90e-01 | 0.0e+00 | Ccl2,CXCL10,CXCL3,IL12B,KDR,KRT17,S100A8,SDC4 | 268 (11) |
| 2-acetylaminofluorene | NA | chemical toxicant | NA | 9.90e-01 | 1.0e-02 | ABCB1,CDKN1A,DLK1,DLL1 | 347 (10) |
| TAB1 | 1.10e-01 | enzyme | NA | 9.90e-01 | 0.0e+00 | CDKN1A,CXCL10,GBP2,IFIT1,NFKBIA,PTGS2,SELE,SERPINE1,TNFSF10 | 416 (17) |
| vadimezan | NA | chemical drug | NA | 9.90e-01 | 1.0e-02 | CXCL10,ISG15,NFKBIA,SELE | 364 (16) |
| camptothecin | NA | chemical drug | NA | 9.90e-01 | 0.0e+00 | ABCB1,ABCC2,AR,ARL4A,ATF3,BCL11A,BCL2A1,BCL2L1,BLK,BTG2,CCL2,Ccl2,CD22,CD300C,CD83,CDKN1A,CIDEA,CREB1,CXCL2,CXCL3,CXCL6,EDN1,ENC1,ENO3,F2RL1,F3,FOS,FOXC1,GADD45A,GADD45B,GADD45G,GBP2,GNAI2,GRINA,GRK5,HSPA4L,IL1A,ITGA7,LGALS3,LIMK1,LPIN1,MAFF,MERTK,MMP9,Mt1,MYC,NFKBIA,NRP1,OSR2,P2RY10,PGLYRP1,PIK3C2B,PTGS2,PTPRN,PTX3,RCN1,ROR2,RSAD2,SAT1,SDC4,SELE,SELP,SERPINE1,SERPINH1,SFN,SIT1,STK17B,STK38L,TNFAIP6,TP73,TPBG,TRA2A,TRIB1 | 432 (14) |
| TMPRSS6 | -6.30e-01 | peptidase | NA | 9.90e-01 | 1.0e-02 | BMP6,CDKN1A,SERPINE1,ZEB2 | 207 (9) |
| PRKD | NA | group | NA | 9.90e-01 | 0.0e+00 | Ccl2,CCL4,CPT1B,CXCL10,CXCL2,CXCL3,CXCL6,IL12B,PDK4,PPARA,PTGS2 | 412 (16) |
| ADAM12 | -3.20e-01 | peptidase | NA | 9.90e-01 | 2.0e-02 | ADAMTS15,Ccl2,CCL24,IL33,ITGA7,JUNB,LAMA5,MGP,SERPINE1 | NA |
| SHC1 | 2.00e-01 | other | NA | 9.80e-01 | 0.0e+00 | BCL2L1,CCL19,Ccl2,CD69,CDKN1A,CXCL10,FOS,FTL,KRT7,SDC4,SELE,SERPINE1 | 423 (14) |
| C1Q (family) | NA | group | NA | 9.80e-01 | 0.0e+00 | CD163,CD274,CEBPD,MERTK,MX1,SELE,TNFSF10 | 325 (11) |
| calcipotriene | NA | chemical drug | NA | 9.70e-01 | 0.0e+00 | FOS,FOSL1,IL33,JUNB,PLAUR,PTGS2,SERPINE1 | 480 (17) |
| MMP9 | -1.09e+00 | peptidase | NA | 9.70e-01 | 0.0e+00 | BCL2L1,Ccl2,CD274,CDKN1A,CLDN5,CXCL2,CXCR4,FOS,GADD45A,ICAM5,IL1A,MMP9,MUC5B,MYC,SDC4,STAP1,THBS1,TIMP1,WNT7A | 367 (14) |
| 3-methylcholanthrene | NA | chemical toxicant | NA | 9.60e-01 | 0.0e+00 | ABCB1,Chn1,FOS,Gsta1,Mt1,NEDD9,PON1,POR,PTGS2 | 469 (13) |
| SRC (family) | NA | group | NA | 9.60e-01 | 0.0e+00 | ATP1A1,BMP2,CCL2,Ccl2,IL12B,MAOA,PTGS2,SOX2,STAT1 | 457 (19) |
| TNFSF10 | -9.60e-01 | cytokine | NA | 9.60e-01 | 0.0e+00 | BCL2L1,CD14,CD274,CD28,CD3G,CD69,CXCR4,DDIT4,FOS,IFIT1,IFITM2,ISG15,LCK,MMP9,NFKBIA,PER1,PIK3IP1,PTGS2,PTPRC,SELE,SERPINH1,STAT1,TIMP1,TNFSF10 | 423 (14) |
| NTRK1 | 4.50e-01 | kinase | NA | 9.60e-01 | 0.0e+00 | BCL2L1,CDKN1A,FOS,GADD45A,MMP9,WNT5A | 369 (17) |
| ZC3H12C | 5.00e-01 | other | NA | 9.50e-01 | 0.0e+00 | GBP2,GBP7,Igtp,IL12B,Kctd12b,STAT1,ZC3H12A | 237 (11) |
| phenobarbital | NA | chemical drug | NA | 9.50e-01 | 0.0e+00 | ABCC2,CDKN1A,CYP7B1,DIO1,GADD45B,Gsta1,HNF4A,KCNK1,PCK1,SAT1,Slco1a1,SLCO1C1,TRPC3 | 513 (24) |
| dopamine | NA | chemical - endogenous mammalian | NA | 9.50e-01 | 0.0e+00 | ATF3,ATP1A1,BCL2L1,BTG2,CCDC146,CCL19,CCL2,Ccl2,CD69,CSRNP1,CXCL10,CXCL2,CXCL3,DUSP8,EGR3,FOS,GFI1,GNRH1,HAS1,HMOX1,IL12B,IL1A,KCNJ12,KCNK1,KCNK2,KCNN3,LRTM2,NPR3,PDE10A,PER1,PPP1R1B,SCN1B,SYT6,TGFA,TMEM205,TNFRSF14,Tnfsf9,TRPV1 | 466 (21) |
| S-nitrosoglutathione | NA | chemical toxicant | NA | 9.50e-01 | 0.0e+00 | BCL2L1,CCL2,CD8A,CDKN1A,CXCL10,IL12B,IRS1,LIF,NFKBIA,PTGS2,SELE | 378 (15) |
| Pam3-Cys | NA | chemical toxicant | NA | 9.50e-01 | 0.0e+00 | CCL2,CD14,CD163,CD69,CD83,CXCL10,CXCL2,CXCL3,IL12B,IL1A,PLAT,POU2AF1,SELE,SERPINE1,TGFA | 451 (14) |
| ITGAM | NA | transmembrane receptor | NA | 9.50e-01 | 0.0e+00 | BCL2A1,Ccl2,CCL4,CD28,CXCL10,IL12B,LCN2,PTGS2,TIMP1,ZBP1 | 334 (19) |
| oleanolic acid | NA | chemical - endogenous non-mammalian | NA | 9.50e-01 | 1.0e-02 | ABCC2,CDKN1A,GCLC,HMOX1,MMP9,SLC5A1,SOCS3 | 451 (18) |
| beta-naphthoflavone | NA | chemical toxicant | NA | 9.50e-01 | 2.0e-02 | Chn1,CRP,CYP2S1,FOS,GCLC,Gsta1,SOCS2 | NA |
| MET | -1.50e-01 | kinase | NA | 9.40e-01 | 0.0e+00 | AQP3,ARID5A,AURKB,CD274,CDKN1A,CTSV,EDN1,FOS,GCLC,GLIS1,HDC,HMOX1,INHBA,LTA,MERTK,MYC,PTGS2,RILPL1,SOCS3,SOX2,TGFA,TNFSF8,TRIM63,ZEB2 | 474 (20) |
| CD3 group | NA | group | NA | 9.30e-01 | 1.0e-02 | CBLB,FASN,GBP2,HK2,ODC1,SLC16A3,SLC7A5,TBX21 | 455 (16) |
| NFATC2 | -1.00e-01 | transcription regulator | NA | 9.30e-01 | 0.0e+00 | BCL2L1,CCL17,Ccl2,CCR9,CD274,CD3G,CD40LG,CD83,CDKN1A,CMPK2,COL2A1,CX3CR1,CXCL10,CXCL2,CXCL3,EDN1,EGR3,EZH2,FCER2,GBP4,IER3,IL12B,IL1A,INHBA,IRF4,ISG15,LMO4,MERTK,Mx2,MYC,NFKBIA,NGFR,PLAT,PPP3R1,PTGS2,RILPL1,RSAD2,SELE,SLAMF6,SOCS2,SOCS3,STAT1,TBX21,TNFSF8,Tnfsf9 | 492 (15) |
| mir-24 | NA | microRNA | NA | 9.30e-01 | 1.0e-02 | CCR6,CDKN1A,IL12B,JPH2,KDR,MYC,SERPINE1,TBX21 | NA |
| miR-34a-5p (and other miRNAs w/seed GGCAGUG) | NA | mature microRNA | NA | 9.30e-01 | 0.0e+00 | ATF3,BVES,CD69,CDKN1A,CREB1,CTSW,DLL1,EFHD1,FAM221A,FCMR,HAPLN3,IFITM2,IKZF3,MUC5B,MYC,MYCN,SELL,SOX2,THBS1,THEMIS | NA |
| estrogen | NA | chemical drug | NA | 9.30e-01 | 0.0e+00 | ALB,AOC1,APCS,APOB,AR,BMP2,CCL2,CDKN1A,CRY2,DUSP1,ERBB3,FOS,GAL,GJB2,GNRH1,GRIN2D,IL1A,IRS1,JUNB,KCNH1,KDR,LCN2,LIF,MEOX2,MYC,NFIL3,NGFR,PLAT,PTGS2,PTX3,SFTPB,Slco1a1,STAT1,TBX21,TGFA,TRIM16,ZFP36 | 545 (21) |
| E. coli B4 lipopolysaccharide | NA | chemical toxicant | NA | 9.30e-01 | 0.0e+00 | ABCB11,ADAMTS5,AQP1,B3GNT5,BCL2L1,CCL2,Ccl2,CCL4,CD274,CD40LG,CD83,CLEC14A,Csprs (includes others),CXCL10,CXCL2,CXCL3,CXCL6,EVI2B,F3,FIBIN,GADD45G,GBP2,GBP4,HK2,HMOX1,Igtp,IL12B,IL1A,IL33,Klrb1f,LCN2,LILRB3,NFKBIA,Oasl2,PLAUR,PPARA,PPP1R1B,PTGS2,PTPRC,RAB20,RSAD2,SARM1,SELE,SERPINH1,SLC6A12,SOCS3,TNFRSF8,TNFSF10,TNFSF8,TXNIP,USP18,ZBP1 | 301 (18) |
| PRL | NA | cytokine | NA | 9.30e-01 | 0.0e+00 | ANXA3,BCL2L1,CCL2,Ccl2,CD69,CDKN1A,CEBPD,CLDN5,CMPK2,CTSH,CTSV,CXCL10,CXCL2,CXCL3,ERBB3,FOS,GNRH1,HSD11B2,IER3,IFI44,IFI44L,IFIT1,ISG15,LIF,LYVE1,MGP,MYC,NEDD9,NUPR1,OAS2,ODC1,PDK4,PLAT,PLCD1,RCL1,RSAD2,SLC10A1,SOCS2,SOCS3,STAT1,TIMP1,TNFRSF12A,TRIM14,TXNIP,USP18,XDH | 421 (17) |
| VitaminD3-VDR-RXR | NA | complex | NA | 9.30e-01 | 4.0e-02 | CD14,CDKN1A,CXCL10,GADD45A,HSD17B2,SERPINB1 | NA |
| PTBP1 | -2.00e-02 | enzyme | NA | 9.30e-01 | 1.0e-02 | CD274,CIRBP,FOSL1,MYC,WNT5A | NA |
| CEBPB | 3.50e-01 | transcription regulator | NA | 9.30e-01 | 0.0e+00 | ABCB1,ADH1C,ALB,AOC1,APCDD1,APCS,APOB,AURKB,BCL2A1,BCL2L1,C3AR1,CCL2,Ccl2,CCL4,CD14,CD163,CD274,CDKN1A,CDO1,CEBPD,CIRBP,CPB2,CPT1A,CRP,CSF3R,CXCL10,CXCL2,CXCL3,CXCR4,EZH2,FOS,FTL,GADD45A,Gsta1,HDC,HPX,HSD11B2,IER3,IKBKE,IL12B,IL1A,IL24,IRF4,IRS1,LCN2,LPIN1,MGP,MYC,NRP1,NUPR1,ODC1,PCK1,PCTP,PDK4,PLAUR,PLG,PLXND1,PPARA,PTGS2,RAD18,SAT1,SERPINE1,SESN2,SLC10A1,SLC38A2,SLC7A1,SOCS3,STAT1,TBRG4,TNFAIP6,TNFRSF19,UPP1,XDH,XPO1 | 473 (17) |
| CAV1 | 2.50e-01 | transmembrane receptor | NA | 9.20e-01 | 1.0e-02 | ADAMTS4,ADGRG2,CD14,CDKN1A,CXCL10,FOS,HK2,HMOX1,INHBA,KDR,KRT7,MUC5B,NEDD4L,SERPINE1,SOX2,THBS1 | NA |
| IL17F | NA | cytokine | NA | 9.20e-01 | 0.0e+00 | CCL2,Ccl2,COL2A1,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,PTGS2 | 391 (14) |
| YY1 | -1.10e-01 | transcription regulator | NA | 9.20e-01 | 0.0e+00 | ACTC1,ANKRD1,ATF4,AURKB,BCL2L1,BMP6,BTG2,BTLA,CCL2,CD22,CDKN1A,CIITA,CR2,CXCR4,DDIT4,DKK2,EDN1,FOS,GADD45G,GRIN2D,HMOX1,ID4,IL1R2,KDR,MYC,NGFR,PDGFD,PEMT,Pmaip1,RAD18,RND3,SFPQ,SHC2,TIMP1,TNFRSF13C,TRA2A | 518 (21) |
| FAT1 | 2.70e-01 | other | NA | 9.20e-01 | 5.0e-02 | PRRX1,PTGS2,SOX2,ZEB2 | NA |
| NRF1 | 5.00e-02 | transcription regulator | NA | 9.10e-01 | 4.0e-02 | ATP1A1,ATP1B1,GCLC,HMOX1,HPCAL1,IL1A,Mt1,Pmaip1 | NA |
| BDNF | 3.20e-01 | growth factor | NA | 9.10e-01 | 0.0e+00 | AR,ARVCF,BCL2L1,BHLHE40,BMP2,BMP7,CAMK1G,CDKN1A,CXCR4,DNAJB5,DUSP1,EGR3,FOS,FTL,GLUL,GRB14,HSPA4L,IFRD1,KIF21B,LCN2,LIMK1,MYCN,NCDN,NELL2,NGFR,P4HA1,PFKFB3,PLG,PPP1R1B,RYR2,SBK1,SERPINH1,Sik1,SOSTDC1,TBC1D8,THBS1,TRH,TRPC3,TXNIP | 496 (25) |
| lysophosphatidylcholine | NA | chemical - other | NA | 9.10e-01 | 3.0e-02 | CCL2,Ccl2,CD274,F3,FASN,MMP9,PLAUR,PTGS2,SELE,SERPINE1 | NA |
| CpG ODN 1668 | NA | chemical reagent | NA | 9.10e-01 | 0.0e+00 | BCL2L1,Ccl2,CCL4,CD69,CXCL10,CXCL3,IL12B,IL1A,ISG15,PTGS2,SOCS3,STAT1,TLR5 | 269 (17) |
| PLX5622 | NA | chemical drug | NA | 9.00e-01 | 0.0e+00 | ATF4,BMP2,C3AR1,CCL17,CCL19,CCL2,Ccl2,CCL24,CCL4,CCR10,CCR3,CCR6,CD14,CD40LG,CDKN1A,CNTNAP1,CX3CR1,CXCL10,CXCL6,GNRH1,GRIN2D,ICAM5,IL1A,IL2RB,IL33,IL4R,IL6R,LOXL1,LTA,LTB,LY86,NELL2,Nrgn,PRKCG,Siglech,STAT1,TMEM119,TNFSF10,TRPV1 | 179 (7) |
| colistin | NA | biologic drug | NA | 9.00e-01 | 2.0e-02 | AK1,Bhlhe41,BMP6,BMP7,CD69,FOS,JUNB,KHDRBS3,LAG3,LGALS3,SEZ6L,SOCS2 | NA |
| kanamycin A | NA | chemical drug | NA | 9.00e-01 | 2.0e-02 | AK1,Bhlhe41,BMP6,BMP7,CD69,FOS,JUNB,KHDRBS3,LAG3,LGALS3,SEZ6L,SOCS2 | NA |
| metronidazole | NA | chemical drug | NA | 9.00e-01 | 3.0e-02 | AK1,Bhlhe41,BMP6,BMP7,CD69,FOS,JUNB,KHDRBS3,LAG3,LGALS3,SEZ6L,SOCS2 | NA |
| sodium arsenite | NA | chemical drug | NA | 9.00e-01 | 0.0e+00 | ABCC2,CBS/LOC102724560,CDKN1A,EGR3,FKBP5,FOS,GADD45A,GADD45B,GCLC,HK2,HMOX1,PCK1,SOCS3,TNFSF10 | 479 (16) |
| CXCL2 | 1.85e+00 | cytokine | NA | 9.00e-01 | 0.0e+00 | Ccl2,CCL4,CXCL10,CXCL2,CXCL3,IFRD1 | 427 (16) |
| NTRK2 | -2.70e-01 | kinase | NA | 9.00e-01 | 0.0e+00 | ABCB1,BMP2,CDKN1A,DDX11,FOS,MYC,MYCN,SERPINE1,SYT1,THBS1,TNFSF10,TP53BP2 | 438 (22) |
| stearic acid | NA | chemical - endogenous mammalian | NA | 9.00e-01 | 1.0e-02 | ATF3,EDN1,F2RL1,NFKBIA,PPARGC1B,PTGS2 | 385 (17) |
| pinometostat | NA | chemical drug | NA | 9.00e-01 | 3.0e-02 | AOC1,CDKN1A,CIITA,CXXC5,EZH2,PDK4 | NA |
| 2-methoxyestradiol | NA | chemical - endogenous mammalian | NA | 9.00e-01 | 3.0e-02 | ATF3,BCL2L1,CXCR4,F3,LOX,PTGS2 | NA |
| ETS2 | -1.00e-01 | transcription regulator | NA | 8.90e-01 | 0.0e+00 | BCL2L1,CD79A,CDKN1A,FOS,HMOX1,IL12B,ITGA2B,JUNB,MMP9,MYC,SOX2 | 515 (25) |
| bucladesine | NA | chemical toxicant | NA | 8.90e-01 | 0.0e+00 | Acan,ACER2,ADAMTS1,ADGRL2,AR,C3AR1,CAMK1G,CD14,CD40LG,CD8A,CDKN1A,COQ10B,CPT1A,CR2,CREB1,CREM,CXCL10,CXCL3,CXCR4,DCLK3,DIO1,DIO2,DUSP1,EPHA4,ERRFI1,EZH2,F3,FOS,FOSL1,FOSL2,FSTL3,GADD45B,GEM,GLUL,GNRH1,Gsta1,HAS1,HCRTR1,HMOX1,HSD11B2,ID4,IRAK2,JAK3,JUNB,LGALS12,LIF,LRRN3,MCAM,MMD,MMP9,Mt1,MYC,MYCN,ODC1,PCK1,PDE10A,PDE4C,POU2AF1,PTGS2,Rcan1,RGN,RGS16,SERPINE1,SFTPB,Sik1,SLC6A17,SMARCA1,SMIM3,SOCS3,SOX7,TGFBR3,TIMP1,TINAGL1,ZEB2 | 457 (18) |
| INS | NA | other | NA | 8.90e-01 | 0.0e+00 | Acan,ADCYAP1R1,AQP3,BCL2L1,CBS/LOC102724560,Ccl2,CDKN1A,CIDEA,COL2A1,CPT1A,CRP,DUSP1,EDN1,ERBB3,ERRFI1,F3,FASN,FOS,FOSL1,FOSL2,GABARAPL1,IER3,IRS1,JUNB,OGT,PCK1,PTGS2,RASL12,SELP | 488 (22) |
| thyroid hormone | NA | chemical - endogenous mammalian | NA | 8.80e-01 | 0.0e+00 | ATF4,BTG2,CCNA1,CDKN1A,CPT1A,Cyp4a14,DIO2,FASN,FOS,GNRH1,KCNA5,MYC,PCK1,PER1,PPARA,SEMA5B,SEMA6B,SLC6A2,STAT1,TCEA3,THRB,TRH | 451 (21) |
| FABP5 | 4.40e-01 | transporter | NA | 8.80e-01 | 0.0e+00 | CCL4,CXCL3,FABP3,GADD45B,PTGS2,SOCS3 | 525 (22) |
| JUND | 7.00e-02 | transcription regulator | NA | 8.80e-01 | 1.0e-02 | C3AR1,CXCL10,F3,FOSL1,HMOX1,IL21R,MMP9,PLAUR,SAT1,TBX21,TIMP1 | 486 (19) |
| NAA10 | 1.30e-01 | enzyme | NA | 8.80e-01 | 1.0e-02 | CIDEA,CPT1B,FABP3,TGFBR3 | NA |
| silicon dioxide | NA | chemical drug | NA | 8.80e-01 | 0.0e+00 | CCL2,FOS,FOSL1,IL12B,JUNB,MAP1LC3B | 440 (19) |
| JAK3 | -7.10e-01 | kinase | NA | 8.80e-01 | 0.0e+00 | CD274,CD40LG,GADD45G,GLI1,IL12B,KLHL31,LAG3,MAPK15,SOCS3 | 440 (18) |
| TAFAZZIN | NA | enzyme | NA | 8.80e-01 | 0.0e+00 | ADAMTS1,ADAMTS5,ANKRD1,ARNT2,BANK1,BTLA,CCL2,Ccl2,CD180,CD19,CD22,CD69,CD79B,CDCA7,CDH6,CXCL2,CXCL3,CXCR4,DNASE1L3,DUSP1,EDN1,F2RL1,FCER2,HMOX1,IFIT1,IL12B,IRAK2,IRF4,Irgm1,IRS1,LOX,MS4A1,MYC,P4HA1,PCLO,PRKCB,PTGS2,PTX3,RNF213,SELP,SERPINB1,SERPINE1,ST6GALNAC5,STAT1,TELO2,TFPI2,THBS1,TIMP1,UPP1,WNT11 | 363 (14) |
| TICAM1 | NA | other | NA | 8.80e-01 | 0.0e+00 | CCL2,Ccl2,CCL4,CEBPD,CMPK2,CXCL10,CXCL2,CXCL3,CXCL6,DUSP1,IFIT1,Igtp,IKBKE,IL12B,IL1A,Irgm1,ISG15,LPAR1,MAFF,Mx2,Nes,NFKBIA,PTGS2,RSAD2,SELE,SERPINE1,SOCS3,TNFSF10,Tnfsf9 | 286 (17) |
| CCN1 | NA | other | NA | 8.70e-01 | 0.0e+00 | BCL2L1,CCL2,Ccl2,CCL4,CDKN1A,CXCL10,CXCL2,CXCL3,IL12B,IL1A,KDR,MMP9,MYC,PTGS2,SERPINE1,TIMP1,TNFSF10,WNT5A,WNT7A | 438 (17) |
| TRAF3IP2 | 3.00e-01 | enzyme | NA | 8.70e-01 | 0.0e+00 | Ccl2,CCL24,CCR3,CEBPD,CXCL10,CXCL2,CXCL3,CXCL6,GFI1,IL33,ISG15,LCN2,MMP9,S100A8,SELP,TNFRSF12A,ZC3H12A | 403 (13) |
| nitroarginine | NA | chemical reagent | NA | 8.70e-01 | 0.0e+00 | ALB,CCL2,GCLC,GNRH1,HMOX1,NFIL3,PLAT | 516 (19) |
| TSC22D3 | NA | transcription regulator | NA | 8.70e-01 | 1.0e-02 | CCL2,CD274,CD83,CDKN1A,DUSP1,EGR3,PTGS2,SELE | 397 (16) |
| 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine | NA | chemical reagent | NA | 8.70e-01 | 0.0e+00 | BCL2A1,BMP2,CCL2,IL1A,MYC,MYOCD,PTGS2 | 403 (17) |
| LILRB4 | -3.80e-01 | other | NA | 8.70e-01 | 0.0e+00 | CD79B,CD8A,CSF3R,CXCL10,IL1A,IRF4,KLRD1 | NA |
| intralipid | NA | chemical drug | NA | 8.60e-01 | 0.0e+00 | APOB,CXCL3,ERN1,FOS,GAL | NA |
| Tlr | NA | group | NA | 8.60e-01 | 0.0e+00 | CCL2,Ccl2,CCL4,CD83,CXCL10,CXCL3,DUSP1,IL12B,IL33,IRF4,LCN2,NFKBIA,PAX5,PTGS2,RGS16,RGS18,SOCS3,SPHK1,STAT1,WNT5A,ZC3H12A | 361 (17) |
| FGFR3 | -1.30e-01 | kinase | NA | 8.60e-01 | 0.0e+00 | BCL2L1,CCL4,CD274,CDKN1A,CR2,DLL1,FOS,HK2,LTB,MMP9 | 389 (16) |
| naringenin | NA | chemical - endogenous non-mammalian | NA | 8.60e-01 | 0.0e+00 | CCL4,CLDN4,CPT1A,CXCL10,HMOX1,MMP9,PON1,PTGS2 | 446 (22) |
| PLD1 | -4.00e-02 | enzyme | NA | 8.60e-01 | 5.0e-02 | MYC,Pmaip1,PTGS2,TP73 | NA |
| KAT2B | -3.00e-01 | transcription regulator | NA | 8.60e-01 | 0.0e+00 | ABCB1,CCL2,CDKN1A,EDEM1,FASN,GLI1,HK2,ISG15,PFKFB3,PTGS2 | 466 (21) |
| PTGS2 | 9.50e-01 | enzyme | NA | 8.50e-01 | 0.0e+00 | ADCY5,AQP1,ARG2,BCL2L1,CCL2,Ccl2,CCL4,CD163,CD274,CDKN1A,CIITA,CXCL10,CXCL3,CXCR4,DLK1,DUSP1,DYNLL1,EDNRA,ERBB3,FOS,IRX1,KDR,MMP9,MYC,NKD2,PTGER1,PTGER3,PTGS2,SELL,SEMA7A,SOCS2,TET1,TNFAIP6,TNFRSF12A,TNFSF10 | 486 (20) |
| EIF2AK4 | 2.70e-01 | kinase | NA | 8.50e-01 | 1.0e-02 | ATF3,ATF4,CIDEA,DDIT4,FASN,HMOX1,IL12B,PSAT1 | 287 (7) |
| HSF1 | 5.00e-02 | transcription regulator | NA | 8.50e-01 | 3.0e-02 | ABCB1,BCL2L1,BMP7,C1orf226,CD274,CPT1B,DLGAP1,FASN,HMOX1,HSPA4L,INHBA,IRS1,KCNF1,LIF,PNPLA2,SERPINH1,SNCAIP,SYCE1,TEX12,TRPV1,UBC,ZFAND2A | NA |
| FSH | NA | complex | NA | 8.50e-01 | 0.0e+00 | ADAMTS1,AQP3,AR,BCL11A,BTG2,CAP2,CDC42EP4,CREM,CRYM,CTSV,CXCR4,DHH,DUSP1,DUSP9,ENC1,EREG,FKBP5,FOS,FOSL1,FOSL2,GCLC,GEM,GRK5,GZMB,HCRTR1,HK2,ID4,IL6R,INHBA,JUNB,LOX,LRRC32,MAP1LC3B,MMP9,MYC,NPC2,P4HA2,PCK1,PDLIM3,PLA1A,PLAT,PLCL1,PPARA,PPP3R1,PTGS2,PTPRN,RGS16,SERPINE1,SNAP23,STAT1,TFPI2,TGFBR3,THBS1,TIMP1,TNFAIP6,TRIB1,UPP1,ZNF519 | 600 (18) |
| MYF6 | 2.00e-02 | transcription regulator | NA | 8.50e-01 | 0.0e+00 | CCL17,Ccl2,CCL24,CCL28,CDKN1A,CTSH,CXCL10,DLL1,FNDC5,IL1A,IL33,INHBA,LIF,LTA,MLC1,MMP8,PDGFB,SCN4A,SERPINE1,THBS1,TNFRSF14,TNFRSF8 | 193 (7) |
| cephaloridine | NA | chemical drug | NA | 8.50e-01 | 0.0e+00 | ABCC2,CCL17,CXCL10,DDIT4,FCN1,GNAI2,HMOX1,KCNH1,MMP16,NGFR,OSMR,RYR2,TNFRSF12A | NA |
| N-methyl-D-aspartate | NA | chemical drug | NA | 8.50e-01 | 0.0e+00 | ATP2B3,ATP2B4,BCL2L1,CCL2,FOS,GNRH1,LIF,LIMK1,MYC,PTGS2,SERPINF2,SLC7A1 | 382 (17) |
| phospholipid | NA | chemical - endogenous mammalian | NA | 8.50e-01 | 0.0e+00 | Ccl2,CCL4,CXCL10,CXCL3,F3,PTGS2 | 329 (21) |
| YY2 | NA | transcription regulator | NA | 8.50e-01 | 0.0e+00 | CXCR4,FOS,MYC,SOX2,TET1 | NA |
| BARX2 | -7.00e-02 | transcription regulator | NA | 8.50e-01 | 0.0e+00 | DYNLL1,HK2,MMP9,TIMP1,TIMP3 | NA |
| H-151 | NA | chemical reagent | NA | 8.50e-01 | 0.0e+00 | CD274,CXCL10,IFI44,IFIT1 | NA |
| PIM3 | 5.80e-01 | kinase | NA | 8.50e-01 | 0.0e+00 | BCL2L1,MYC,SELL,TBX21 | NA |
| SLC2A3 | 3.00e-02 | transporter | NA | 8.50e-01 | 1.0e-02 | H6PD,HK2,PFKFB3,SLC16A4 | NA |
| DDR1 | 1.10e-01 | kinase | NA | 8.50e-01 | 1.0e-02 | BCL2L1,Ccl2,CDKN1A,MMP9 | NA |
| S100B | -1.80e-01 | other | NA | 8.50e-01 | 2.0e-02 | Ccl2,CDKN1A,FOS,MYC | NA |
| KDM4B | 3.30e-01 | enzyme | NA | 8.50e-01 | 4.0e-02 | HK2,LCN2,LOX,PDGFB | NA |
| FOXF2 | NA | transcription regulator | NA | 8.50e-01 | 5.0e-02 | CDKN1A,MYOCD,PDGFB,WNT5A | NA |
| JAK1 | 1.00e-02 | kinase | NA | 8.40e-01 | 0.0e+00 | CCL2,CD14,CDKN1A,FOS,IL4R,JUNB,LIF,MAP3K8,MX1,Oasl2,OSMR,PDGFB,SFTPB,SOCS3,STAT1,TNFRSF21,TNS4,USP18 | 456 (19) |
| bee venom | NA | chemical - endogenous non-mammalian | NA | 8.40e-01 | 0.0e+00 | Ccl2,CDC42EP4,CREM,GADD45A,HAS1,HSPA4L,IFRD1,ITPKC,JUNB,LPIN2,MAP3K8,NFIL3,NFKBIA,NUPR1,PTGS2,SOCS3,Tnfsf9 | 338 (10) |
| PPP2CA | 1.20e-01 | phosphatase | NA | 8.30e-01 | 0.0e+00 | Ccl2,CD69,CDKN1A,CXCL10,CXCL3,GZMA,IL1A,IL2RB,MYC,PTGS2,PTPRC,SELL,SOCS3,STAT1,UPP1 | 455 (23) |
| fluocinolone acetonide | NA | chemical drug | NA | 8.30e-01 | 0.0e+00 | ACKR4,AQP1,BCL2L1,BMP3,FKBP5,HSD11B2,IL33,KLF15,PRKCB,RGCC,SOCS3,TMEM14A,ZBTB16 | 337 (10) |
| ACTN4 | 3.40e-01 | transcription regulator | NA | 8.30e-01 | 0.0e+00 | CCL2,FOS,MMP9,MYC,MYCN,SERPINE1,WNT5A | 405 (16) |
| SOX1 | NA | transcription regulator | NA | 8.30e-01 | 0.0e+00 | APCDD1,BMPER,DUSP1,EPHA2,GBP4,INHBA,IRS1,NRP1,Oasl2,TNFRSF19,TXNRD1,USP18,WNT5A | NA |
| FGF4 | NA | growth factor | NA | 8.30e-01 | 4.0e-02 | Ccl2,CDKN1A,FOS,SOSTDC1 | NA |
| RPS6KA3 | -3.10e-01 | kinase | NA | 8.30e-01 | 1.0e-02 | FOS,IRF4,MYC,PTGS2 | NA |
| azoxymethane | NA | chemical toxicant | NA | 8.20e-01 | 0.0e+00 | Ccl2,CCL4,CDKN1A,CXCL10,CXCL2,CXCL3,CXCL6,FZD10,IL22RA2,MMP9,MYC,ODC1,PRKCB,PTGS2 | 414 (16) |
| Raf | NA | group | NA | 8.20e-01 | 0.0e+00 | CDKN1A,EDN1,FOS,FOSL1,IER3,MAFF,MYC,RND3,SEMA4C,SLC43A3,ST8SIA1 | 398 (18) |
| diallyl disulfide | NA | chemical - endogenous non-mammalian | NA | 8.20e-01 | 3.0e-02 | ATF3,FOS,Gsta1,HMOX1,MUC5B | NA |
| BCOR | -9.00e-02 | transcription regulator | NA | 8.20e-01 | 0.0e+00 | ADAMTS1,BANK1,BMP7,CCNO,CD37,CDKN1A,CIITA,COL2A1,GJB2,IRF4,ISG15,LMO4,MS4A1,MYC | 266 (7) |
| TET2 | 9.00e-02 | enzyme | NA | 8.20e-01 | 0.0e+00 | ADORA2B,AFF3,ASPA,BHLHE40,Ccl2,CMPK2,CXCL6,CYP2S1,FCN1,FOSL2,FOXC1,GRK5,MAFF,MMP8,PXDC1,RND3,RNF144A,RSAD2,S100A8,SOX2,TBX6,TGFA,TGM1,TIMP1,ZBTB16 | 306 (7) |
| Collagen type IV | NA | complex | NA | 8.20e-01 | 0.0e+00 | CCL2,MMP9,MYC,PLAUR,PTGS2,SERPINE1,THBS1 | 484 (23) |
| PKNOX2 | 1.00e+00 | transcription regulator | NA | 8.20e-01 | 0.0e+00 | BTG2,CDKN1A,COL2A1,GADD45A,STAT1,TP73 | NA |
| EMD | 1.00e-01 | other | NA | 8.20e-01 | 0.0e+00 | BMP2,IER3,PPL,SOX2,STAT1,TGM1 | NA |
| CD276 | 6.00e-02 | other | NA | 8.20e-01 | 0.0e+00 | CXCL10,IFIT1,MMP9,MX1,OAS2,SOCS2,STAT1 | 345 (11) |
| PLK4 | -2.40e-01 | kinase | NA | 8.20e-01 | 0.0e+00 | CMPK2,CXCL10,EDN1,MERTK,Mx2,PLAT | 217 (7) |
| sodium tungstate | NA | chemical drug | NA | 8.20e-01 | 1.0e-02 | ACTRT3,AK1,ATP6V1E2,ENO3,HSPA4L,PDHA1 | NA |
| Dst | 4.00e-02 | other | NA | 8.20e-01 | 2.0e-02 | ANKRD1,ANO5,ENKUR,SCN4B,SEC14L5,UBXN10 | NA |
| EP300 | -2.00e-01 | transcription regulator | NA | 8.10e-01 | 0.0e+00 | ADORA2A,AR,ARID5A,BANK1,BCL2L1,CA12,CCL2,CD19,CD274,CDKN1A,COL2A1,CPT1A,CRISPLD2,CXCL3,CXCR4,DIO1,DUSP1,EDN1,FASN,FOS,FOSL2,GFI1,GIMAP4,GIMAP7,H6PD,HK2,HMOX1,HSD11B2,ITGB7,KCNIP3,KDR,LTA,MAP3K8,MMD,MYC,NFKBIA,NTRK3,PCK1,PDE10A,PDK4,PFKFB3,PIPOX,PPARA,PPM1E,PSAT1,PTGS2,RAPGEF3,RAPGEF4,RNF39,RSAD2,SCN4B,SDC4,SELE,SLAMF6,SLC16A3,SLC43A1,SMPD3,SOCS3,SOX2,SPHK1,SPSB1,TESC,TMPRSS4,Tsc22d3,TXNIP,USP18,WNT7A | 478 (14) |
| IGF2 | 9.00e-02 | growth factor | NA | 8.10e-01 | 0.0e+00 | ARL4A,BMP2,Ccl2,CDKN1A,CTSV,CXCR4,DUSP1,EREG,GADD45A,GNAI2,IER3,IFITM2,JUNB,MYC,NFKBIA,PDGFB,PTGS2,RGS16,SAT1,SERPINE1,SFTPB,SLC38A2,SOCS3 | 452 (18) |
| G6PD | -1.00e-02 | enzyme | NA | 8.10e-01 | 2.0e-02 | FASN,KCNMB1,MX1,PTGS2 | NA |
| JAK2 | 1.40e-01 | kinase | NA | 8.10e-01 | 0.0e+00 | ACER2,BCL2L1,BMP7,CCL2,Ccl2,CD19,CD274,CD79A,CDKN1A,CXCL10,F10,FOS,GBP2,GNRH1,LAT2,LCN2,Milr1,MYC,ODC1,OSMR,PAX5,POU2AF1,PRKCB,PTGS2,SDC4,SELP,SEMA6B,SERPINH1,SLC11A1,SOCS3,STAT1,THBS1 | 403 (17) |
| ferric ammonium citrate | NA | chemical drug | NA | 8.10e-01 | 0.0e+00 | BMP6,FTL,GADD45A,HMOX1,MYC,NFYA | 283 (12) |
| KN-62 | NA | chemical drug | NA | 8.10e-01 | 0.0e+00 | ATF3,CD40LG,HNF4A,KCNJ11,MMP9,PTGS2 | 368 (16) |
| fasudil | NA | chemical drug | NA | 8.10e-01 | 1.0e-02 | BCL2L1,BMP2,CCL2,Ccl2,CD14,F3,MMP9 | 351 (15) |
| IKBKE | -8.10e-01 | kinase | NA | 8.00e-01 | 0.0e+00 | ATF4,Ccl2,CXCL10,CXCL2,CXCL6,ENO3,GLI1,IFIT1,IKBKE,IL1A,MMP9,MYC,NFKBIA,PDHA1,PDK4,PSAT1,PTGS2,RSAD2,SLC16A3,STAT1 | 271 (16) |
| peptidoglycan | NA | chemical - endogenous non-mammalian | NA | 8.00e-01 | 0.0e+00 | AQP1,BCL2A1,CCL2,Ccl2,CCL4,CD274,CD69,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DUSP1,FOS,HMOX1,IL12B,IL1A,JUNB,POU2AF1,PTGS2,S100A8,SELL,TLR5 | 309 (12) |
| CLOCK | 3.00e-02 | transcription regulator | NA | 8.00e-01 | 0.0e+00 | ARHGEF28,ARNT2,BHLHE40,CCR6,CEMIP,CHRNA7,CHST3,CHTF8,DUSP8,EFHC1,FAM107A,FASN,FKBP5,GADD45A,GADD45B,GIMAP4,GPR3,IKBKE,JUNB,KCNN3,LPIN1,MGP,MKNK2,MOXD1,NFIL3,NOCT,NR0B2,PER1,POR,PPARA,SCN4B,TBRG4,THBS1,TNFRSF21,Tnfsf9,TRIL | 103 (3) |
| fatty acid | NA | chemical - endogenous mammalian | NA | 8.00e-01 | 0.0e+00 | AOC1,Ccl2,CIDEA,CPT1B,CREB3L3,CREM,FASN,HMOX1,IAPP,IRS1,LPIN2,MMP9,NFKBIA,PLIN5,PPARA,PTGS2,RBP4,S100A8,SERPINE1,SLC30A3 | 541 (23) |
| SMAD5 | -1.10e-01 | transcription regulator | NA | 8.00e-01 | 3.0e-02 | BMP2,ID4,PDGFB,SELE,SERPINE1 | NA |
| phorbol 12,13-didecanoate | NA | chemical toxicant | NA | 7.90e-01 | 2.0e-02 | ABCB1,CDKN1A,DUSP1,MYC,TP73 | NA |
| CXCR4 | -7.00e-01 | G-protein coupled receptor | NA | 7.90e-01 | 0.0e+00 | CCL2,CD69,CDKN1A,CHRNA7,CXCL10,CXCR4,F3,IL24,JUNB,MYC,Podxl,TNFSF10,ZBTB16 | 432 (20) |
| alefacept | NA | biologic drug | NA | 7.90e-01 | 0.0e+00 | ABCB1,CBLB,CD69,CD8A,GZMB,IL12B,IL2RB,KLRD1,PRF1,SOCS3,STAT1,TGFBR3 | NA |
| NOG | -4.10e-01 | growth factor | NA | 7.90e-01 | 0.0e+00 | BMP2,BMP7,CXXC5,ID4,KDR,MYC,NGFR,PTGS2,WNT5A | 517 (25) |
| MSTN | 6.00e-02 | growth factor | NA | 7.90e-01 | 2.0e-02 | BMP2,BMP7,CDKN1A,CTSV,FOS,INHBA,MAP1LC3B,SERPINH1,TRIM63 | NA |
| CD3E | -5.60e-01 | transmembrane receptor | NA | 7.80e-01 | 0.0e+00 | BCL2L1,CBLB,CCL17,CCR9,CD3G,CD69,FOS,LTA,MAP3K8,MMP9,MYC,NFKBIA,PTGS2,SPHK1 | 412 (19) |
| TCF7L2 | 1.00e-01 | transcription regulator | NA | 7.80e-01 | 0.0e+00 | ADAMTS4,ANKRD13A,APCDD1,AQP3,AR,ASPA,CDKN1A,CLDN11,CSF3R,EDN1,ENC1,ERBB3,EVI2B,FOS,GJB1,GLI1,GLUL,HAPLN2,HIPK2,ID4,IRS1,LGI3,LRRN1,MCAM,MYC,NPC2,PCK1,PLAT,PLAUR,PLEKHH1,PTGS2,SNAP23,SORBS3,SOX2,STK17B,SYTL2,TPPP,TRIM59 | 560 (23) |
| ELF4 | -1.60e-01 | transcription regulator | NA | 7.80e-01 | 0.0e+00 | ABCB1,CDKN1A,CREM,CXCL2,DUSP1,HDC,MAPKAPK3,PRF1,SELL | 309 (7) |
| dextran sulfate | NA | chemical drug | NA | 7.80e-01 | 0.0e+00 | ADAMTS1,ADORA2B,CCL19,Ccl2,CCL4,CCNA1,CD14,CD40LG,CD69,CD83,CDKN1A,CLDN5,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,FZD10,GLI1,HMOX1,IL12B,IL22RA2,ISG15,MMP9,MYC,NRP1,ODC1,OSMR,PDGFB,PGF,PTGS2,S100A8,SELP,SERPINE1,SOCS3,SPHK1,SPON2,TGFBR3,THBS1,WNT11,WNT5A | 479 (16) |
| Fc gamma receptor | NA | group | NA | 7.80e-01 | 3.0e-02 | CCL17,CCL19,CDKN1A,IL12B,SOCS3 | NA |
| ADORA2A | -8.50e-01 | G-protein coupled receptor | NA | 7.80e-01 | 0.0e+00 | ATP2B3,CCL17,Ccl2,CD28,CLDN5,CXCL10,CXCL2,DUSP1,FOS,GLI1,HMOX1,IL12B,MMP9,NFKBIA,PPP1R1B,PPP3R1,PTGS2,SELE | 358 (13) |
| monophosphoryl lipid A | NA | chemical drug | NA | 7.80e-01 | 1.0e-02 | Ccl2,CXCL10,IL12B,IL1A | 340 (19) |
| MAPK12 | 1.00e-01 | kinase | NA | 7.80e-01 | 3.0e-02 | FOS,IL12B,MAP3K8,MMP9 | NA |
| LIN28B | 2.00e-02 | other | NA | 7.70e-01 | 0.0e+00 | BCL11A,CDKN1A,COL2A1,FASN,GFI1,MYC,MYCN,SOX2,TGFBR3,THRB,ZEB2 | 235 (7) |
| ICAM1 | -1.40e-01 | transmembrane receptor | NA | 7.70e-01 | 0.0e+00 | CCL4,CD69,CXCL2,CXCL3,FOS,IL1A,MMP9,MYC,ZEB2 | 322 (15) |
| NPPA | -2.70e-01 | other | NA | 7.70e-01 | 1.0e-02 | DUSP1,EDN1,HMOX1,IL12B,NPR3,PTGS2 | 478 (17) |
| Z-LLL-CHO | NA | chemical - protease inhibitor | NA | 7.70e-01 | 0.0e+00 | ABCB1,ABL1,AGR2,AR,ATF3,ATF4,ATP1A1,BBOX1,BCL2A1,BCL2L1,CBS/LOC102724560,CCL2,Ccl2,CDKN1A,CLDN4,CRP,CXCL10,CXCL2,DUSP1,DUSP8,EZH2,FASN,FOS,G0S2,GLI1,HMOX1,IER3,IL12B,IRS1,MMP9,MYC,MYCN,NFKBIA,ODC1,PFKFB3,PPARA,PTGS2,SFTPB,SOCS3,SOX2,STAT1,THBS1,TIMP1,TP53BP2,TP73 | 489 (19) |
| CTNNB1 | 4.00e-02 | transcription regulator | NA | 7.70e-01 | 0.0e+00 | ABCB1,Acan,ACAP1,ACTC1,ADGRG2,APCDD1,AR,ARL4A,BCL2L1,BHLHE40,BMP2,BMP7,CCL2,Ccl2,CCL4,CCNA1,CD274,CDKN1A,CLDN5,COL2A1,CPT1A,CPT1B,CTHRC1,CXCL10,CXCL2,CXCL3,CXCL6,CYP7B1,DIO1,DIO2,DKK2,DLK1,EDN1,EDN3,ENC1,ENO3,ERBB3,EREG,FASN,FGFBP1,FOS,FOSL1,FOXC1,FSTL3,GADD45B,GADD45G,GFPT2,GJB1,GJB2,GLI1,GLUL,HK2,HNF4A,HSD17B2,ID4,IFIT1,IL1A,IRF4,IRS1,ITGB7,KDR,KRT7,LCK,LGALS3,LIF,MAOA,MAP1LC3B,MEOX1,MMP16,MMP9,MYC,MYCN,Nes,NEXN,NGFR,NR5A2,PCK1,PLAUR,Podxl,PPP1R13B,PROCR,PRSS35,PTGS2,RBP4,RCN1,RGN,S100A8,SERPINE1,SESN1,SFN,SHOX2,SIX1,SLC6A2,Slco1a1,SOAT1,SORBS3,SOX2,SOX7,SRFBP1,STAT1,TBX21,TELO2,TGFA,TGM1,TIMP1,TIMP3,TNFRSF18,TNFRSF19,TNFSF10,TP73,TRH,WNT11,WNT7A,ZEB2 | 596 (20) |
| CEBPD | 1.32e+00 | transcription regulator | NA | 7.70e-01 | 0.0e+00 | ALB,ATF4,BCL2A1,Ccl2,CD14,CDKN1A,CEBPD,CPB2,CSF3R,CTSV,CXCL3,CXCR4,FOS,HK2,IKBKE,MMP8,MYC,PTGS2,TNFAIP6 | 457 (20) |
| SELP | 1.97e+00 | transmembrane receptor | NA | 7.60e-01 | 0.0e+00 | BCL2A1,CCL2,CCL4,CDKN1A,CXCL2,CXCR4,F3,IL1R2,IL4R,PLAUR,SELP | 566 (18) |
| GRP | NA | growth factor | NA | 7.60e-01 | 2.0e-02 | FOS,IL33,MYC,MYCN,PTGS2 | NA |
| 4-octyl itaconate | NA | chemical reagent | NA | 7.60e-01 | 1.0e-02 | HMOX1,IKBKE,ISG15,PTGS2 | 472 (14) |
| PLG | -6.60e-01 | peptidase | NA | 7.60e-01 | 0.0e+00 | CCL2,CYP2S1,EDN1,F3,GULP1,IL1A,MERTK,MMP9,PLG,PTGS2,RAPGEF3,SERPINE1 | 430 (19) |
| berberine | NA | chemical drug | NA | 7.60e-01 | 0.0e+00 | BCL2L1,CCL2,CDKN1A,CLDN5,CPT1A,Cyp4a14,HMOX1,MMP9,PON1,PPARA,PTGS2,SAT1,SLC10A1,SPHK1,TBX21,TIMP1 | 469 (15) |
| sertraline | NA | chemical drug | NA | 7.60e-01 | 3.0e-02 | ATF4,DDIT4,PDE4A,SLC7A5 | NA |
| SPHK2 | 1.10e-01 | kinase | NA | 7.60e-01 | 1.0e-02 | APOB,CDKN1A,CPT1A,FASN,Siglech,SPHK1 | 463 (22) |
| Ifn gamma | NA | complex | NA | 7.50e-01 | 0.0e+00 | BCL2L1,CCL2,Ccl2,CDKN1A,CXCL10,EDN1,IFI44L,IL33,LIF,MMP9,MYC,PCK1,SOCS3,STAT1,TNFRSF13C,TNFSF10 | 332 (16) |
| AMPK | NA | complex | NA | 7.50e-01 | 0.0e+00 | AR,BMP2,CCL2,Ccl2,CDKN1A,CIITA,CXCL10,FASN,HMOX1,LPIN1,MMP9,NR0B2,PCK1,PFKFB3,PTGS2,SERPINE1,STAT1,Tsc22d3 | 495 (20) |
| HSPA5 | -1.80e-01 | enzyme | NA | 7.50e-01 | 1.0e-02 | BCL2L1,CPT1A,CXCL10,ERN1,FASN,IFIT1,ISG15,MAP1LC3B | 399 (18) |
| METTL3 | -1.50e-01 | enzyme | NA | 7.50e-01 | 0.0e+00 | BTG2,CCL2,Ccl2,CDKN1A,CX3CR1,CXCL10,ISG15,JPH2,KCNJ4,LPIN1,SOCS3,TBC1D8,TIMP1,TNFRSF18 | 336 (19) |
| Integrin | NA | complex | NA | 7.50e-01 | 1.0e-02 | FOS,MMP9,MYC,SOCS3 | NA |
| RAC1 | 1.10e-01 | enzyme | NA | 7.40e-01 | 0.0e+00 | ABCB1,Acan,ANKRD1,ATF3,BCL2L1,Ccl2,CIITA,COL2A1,CRP,DUSP1,FOS,FOSL1,HMOX1,HSD11B2,IL33,IL6R,MMP9,MYC,PLAUR,PTGS2,SOX2,STAT1,WNT5A | 437 (16) |
| USF1 | 4.00e-02 | transcription regulator | NA | 7.40e-01 | 0.0e+00 | CBS/LOC102724560,CIITA,CPT1A,CPT1B,CR2,DUSP1,FASN,GATA5,HK2,MS4A1,Mt1,P4HA1,PCK1,PTGS2,SERPINE1,SPEG,TXNIP,XCL1 | 384 (13) |
| Ni2+ | NA | chemical reagent | NA | 7.40e-01 | 0.0e+00 | CCL2,CXCL2,CXCL3,CXCL6,IL1A,LTB | 369 (17) |
| docetaxel | NA | chemical drug | NA | 7.40e-01 | 3.0e-02 | AR,BCL2L1,CCL17,CDKN1A,CXCL10,EDN3,EDNRA,KDR,MMP9,PTGS2,THBS1,TNFSF10,TRPC3 | NA |
| BRCA1 | -3.20e-01 | transcription regulator | NA | 7.40e-01 | 0.0e+00 | AK1,ANXA8/ANXA8L1,AR,BCL2L1,CDKN1A,DDIT4,FKBP5,GADD45A,GADD45B,HMOX1,HSD11B2,IFIT1,KRT17,LPIN1,MX1,MYC,NEDD9,SAT1,SFN,SFPQ,STAT1,TNFRSF18 | 529 (21) |
| DPP4 | -2.30e-01 | peptidase | NA | 7.30e-01 | 1.0e-02 | Ccl2,CXCL10,CXCL2,IL12B,IL1A,THBS1,TIMP1 | NA |
| IL12A | -4.30e-01 | cytokine | NA | 7.30e-01 | 2.0e-02 | CXCL10,IL12B,IL1A,LTA,SOCS3,STAT1 | NA |
| JUNB | 1.14e+00 | transcription regulator | NA | 7.30e-01 | 0.0e+00 | ATF3,C3AR1,CD274,CXCL2,CXCL3,DUSP1,FASN,FOSL1,HK2,HMOX1,IL12B,INHBA,JUNB,LCN2,LPAR1,MMP9,PLAUR,PNPLA2,RASGRF1,SERPINE1,SLC7A1,SYT1,TIMP1,TIMP3,TNFRSF8 | 531 (19) |
| AURKA | 1.90e-01 | kinase | NA | 7.30e-01 | 0.0e+00 | BCL2L1,CDKN1A,HK2,MYC,SOX2,TP73 | 457 (17) |
| LRP1 | 1.60e-01 | transmembrane receptor | NA | 7.30e-01 | 0.0e+00 | ADGRE1,Ccl2,CCL4,CD14,CREB1,MMP9,PTGS2,SMO,WNT5A | 353 (18) |
| MAFK | 3.70e-01 | transcription regulator | NA | 7.30e-01 | 4.0e-02 | GCLC,HMOX1,ITGA2B,TXNRD1 | NA |
| SUMO3 | 3.20e-01 | other | NA | 7.30e-01 | 0.0e+00 | CHRNA7,CXCL10,GRB14,Ifgga2l1/RGD1309362,IRS1,ISG15,MOXD1,TNFRSF21 | 247 (7) |
| GHRL | -1.00e-02 | growth factor | NA | 7.30e-01 | 2.0e-02 | CPT1A,CPT1B,EDN1,FASN,FOS,PCK1,PTGS2,RAPGEF3,SOCS3 | NA |
| MIF | NA | cytokine | NA | 7.20e-01 | 0.0e+00 | ADGRE1,BCL2L1,C3AR1,CCL2,Ccl2,CCL4,CCR6,CD84,CRP,CXCL10,CXCL2,CXCL3,CXCR4,DUSP1,F2RL1,FASN,FOS,GFI1,GZMB,HSD11B2,IL12B,IL22RA1,IL4R,ISG15,MAP1LC3B,MMP9,MYCN,OAS2,PTGS2,TIMP1,USP18,ZBP1 | 386 (16) |
| seocalcitol | NA | chemical drug | NA | 7.20e-01 | 0.0e+00 | ANKRD1,BCL2L1,CDKN1A,CUBN,FOSL1,GADD45A,IL24,ITGA7,MYC,PTGS2 | 520 (25) |
| SPRY2 | 1.70e-01 | other | NA | 7.20e-01 | 0.0e+00 | BMP2,CDKN1A,CIDEA,CXCL10,CXCR4,FOS,G0S2,GALNT3,IL33,ISG15,LAT2,LIF,LMO4,MAP4K1,MMD,MYCN,PFKFB3,PLAUR,PTGS2,RBP4,SCN1B,SFTPB | 438 (18) |
| ERN1 | 9.70e-01 | kinase | NA | 7.10e-01 | 1.0e-02 | ATF3,ATF4,Ccl2,CCNA1,CDH6,CEBPD,CPT1A,CXCL2,EDEM1,FASN,MAP1LC3B,OAS2,PPARA,SLC7A1,TINAGL1,TXNIP | 478 (19) |
| TIMP1 | 9.50e-01 | cytokine | NA | 7.10e-01 | 0.0e+00 | BCL2L1,CDKN1A,FCER2,IL33,MMP9,PLAT,PLAUR,TIMP3 | 425 (21) |
| KRT17 | 2.06e+00 | other | NA | 7.10e-01 | 0.0e+00 | CCL17,CCL24,CCL4,CXCL10,CXCL2,CXCL3,CXCL6,MMP9 | NA |
| LDHA | NA | enzyme | NA | 7.10e-01 | 0.0e+00 | CREB3L3,DDIT4,EPHA2,ITGA7,LAMA5,LPAR5,NGFR,PDGFB,PGF | NA |
| REST | -3.10e-01 | transcription regulator | NA | 7.00e-01 | 1.0e-02 | ARRDC3,CNTNAP1,CREB3L3,GRIK4,KCNH6,KCNJ6,MYC,Nes,NPC2,NRP1,NTRK3,PCLO,PTPRN,SCN10A,SOX18,SYT1,TRPM2 | NA |
| FN1 | 1.10e-01 | enzyme | NA | 7.00e-01 | 0.0e+00 | CCL2,CCL4,CD79A,CD83,CD8A,CDKN1A,CRP,CXCL2,CXCL3,F3,FOS,IRS1,KIF21B,KRT7,MGP,MMP9,MYC,NFKBIA,PDGFB,PLAUR,SDC4,SERPINE1,SNAP23,SOCS3,SOX2,THBS1 | 410 (18) |
| MAP3K14 | -1.80e-01 | kinase | NA | 7.00e-01 | 0.0e+00 | ADGRE1,BCL2L1,Ccl2,CXCL2,FASN,GADD45A,GBP5,IL1A,IL1R2,LTA,LTB,MMP9,NFKBIA,PTGS2,SIX1,TNFAIP6,TNFSF10 | 298 (15) |
| PPARA | -6.80e-01 | ligand-dependent nuclear receptor | NA | 7.00e-01 | 0.0e+00 | ABCB11,Acot1,APCS,AQP3,BAAT,BCL2L1,C9,Ccl2,CDKN1A,CEBPD,CIDEA,CPT1A,CPT1B,CREB3L3,Cyp4a14,CYP7B1,DIO1,DIO2,DYNLL1,EDN1,FABP3,FASN,FGA,FOS,FTCD,G0S2,GLUL,HMOX1,HNF4A,HPX,IL12B,MMD,MMP9,MYC,NFKBIA,PCK1,PCTP,PDK4,PEX11A,PLIN5,PNPLA2,PON1,POR,PPARA,PTGS2,RBP4,S100A8,SAT1,SELENBP1,SOCS2,STBD1,TBX21,TLR5 | 474 (22) |
| RUNX3 | -5.70e-01 | transcription regulator | NA | 7.00e-01 | 3.0e-02 | ABCC2,AKAP6,CD79A,CDKN1A,CHST3,CIITA,GRK5,KHDRBS3,LILRB3,LOX,MMP9,MYC,XCL1 | NA |
| C/EBP | NA | group | NA | 6.90e-01 | 2.0e-02 | ADH1C,DIO2,Gsta1,IL12B,LCN2,PCK1,PTGS2 | NA |
| 2-deoxyglucose | NA | chemical drug | NA | 6.90e-01 | 0.0e+00 | ABCB1,ATF4,BCL2L1,Ccl2,CDKN1A,DDIT4,FOS,GZMB,HK2,ISG15,KLRD1,MYC,MYCN,ODC1,PRF1,PTGS2,SLC5A1,STAT1,Tnfsf9,TXNIP | 533 (22) |
| TRAF6 | 0.00e+00 | enzyme | NA | 6.90e-01 | 0.0e+00 | CCL17,CCL2,Ccl2,CD274,CREB3L3,CRP,CXCL2,CXCL3,GABARAPL1,IL12B,MAP1LC3B,SELE | 271 (11) |
| corticosterone | NA | chemical - endogenous mammalian | NA | 6.90e-01 | 0.0e+00 | APOB,ATP1A1,ATP1B1,Ccl2,CDKN1A,CLDN5,CPT1A,CPT1B,CRISPLD2,DDIT4,DIO2,EDN1,EDN3,FASN,FKBP5,FOS,GLUL,GZMB,HIF3A,IRS1,LIF,MAOA,MMP9,MYC,PDK4,PNPLA2,PTGS2,SLC6A2,TIMP1,TRH,Tsc22d3 | 468 (20) |
| MDK | 5.00e-02 | growth factor | NA | 6.90e-01 | 0.0e+00 | CCL2,Ccl2,CXCL3,FOSL1,GZMB,LIF,MYOCD,PLAT,PTPRC,S100A8,WNT5A | 355 (19) |
| 25-hydroxycholesterol | NA | chemical reagent | NA | 6.90e-01 | 0.0e+00 | ANGPTL3,ATF3,ATF4,FASN,FOS,FOSL1,FOSL2,HMOX1,JUNB,MAFF,MYC,NFKBIA,ODC1,PTGS2 | 470 (20) |
| CL 316243 | NA | chemical drug | NA | 6.90e-01 | 0.0e+00 | ADGRE1,ATF3,Ccl2,CIDEA,CPT1B,FASN,PDK4,PPARA,PTGS2 | 431 (21) |
| CXCL3 | 2.74e+00 | cytokine | NA | 6.90e-01 | 0.0e+00 | Ccl2,CCL4,CXCL10,CXCL3,GRK5 | 356 (15) |
| FABP4 | -5.20e-01 | transporter | NA | 6.90e-01 | 0.0e+00 | Ccl2,IL12B,IL1A,PPARA,PTGS2,SOCS3 | 450 (20) |
| STAP2 | 2.00e-01 | other | NA | 6.90e-01 | 2.0e-02 | APCS,CXCL2,CXCR4,MYC | NA |
| mir-214 | NA | microRNA | NA | 6.90e-01 | 1.0e-02 | ATF4,Ccl2,CREB1,EZH2,PCK1,PTGS2 | NA |
| epinephrine | NA | chemical - endogenous mammalian | NA | 6.80e-01 | 0.0e+00 | AQP3,CDKN1A,CXCR4,DLK1,HK2,IL12B,IL33,PER1,PTGS2,SELL,TGFA,TLR5,TRIM63 | 472 (18) |
| EIF2AK2 | -1.20e-01 | kinase | NA | 6.80e-01 | 0.0e+00 | ATF3,ATF4,BCL2A1,BCL2L1,BHLHE40,CDKN1A,CEBPD,FOS,IFIT1,IFITM2,IL1A,ISG15,MMP9,MYC,NEDD9,NFKBIA,SELE,SOCS3,STAT1,USP18 | 356 (18) |
| ESR1 | -3.20e-01 | ligand-dependent nuclear receptor | NA | 6.80e-01 | 0.0e+00 | ABCB1,ABCB11,ABLIM1,ACTC1,ADAMTS5,ADH1C,ADORA1,AK1,ANO2,ANXA3,AQP1,AQP3,AR,ARL4D,ARRDC3,ATF3,ATP1B1,BCL2L1,BMP2,CA12,CAP2,CCL2,CCL4,CD69,CD83,CDKN1A,CEBPD,CEP70,CLDN4,CREB1,CXCL3,CYP26B1,Cyp4a14,CYP7B1,DDIT4,DLL1,DUSP9,EDN1,EGR3,ERBB3,EREG,F2RL1,F3,FASN,FOS,FOSL1,FOSL2,FOXC1,FRAT2,GADD45B,GADD45G,GAL,GAS7,GEM,GJB1,GJB2,GNRH1,GPR37,GULP1,HIPK2,HPX,HSF2BP,ICA1,IER3,IFI44,IFI44L,IFITM2,IFRD1,IKBKE,IL1A,IRAK2,IRF4,IRS1,ITGA2B,JAK3,JUNB,KRT17,KRT7,LCK,LCN2,LTB,MAP2K6,MAP3K8,MMD,MMP9,MX1,MYC,NEDD9,NELL2,NFKBIA,NGFR,NPR3,NR0B2,OPHN1,OTUB2,PBK,PDE4A,PDGFD,PDK4,PDLIM3,PKP1,PLAUR,POR,PPP1R3C,PRKCH,PSAT1,PTGER3,PTGS2,PTX3,RAMP3,RBP4,RERG,RGS16,RND3,RSAD2,SCIN,SCN1B,SELE,SELL,SERPINE1,SESN1,SFPQ,SGSM3,SHC2,SIX1,SLC10A1,SLC13A4,SLC16A3,SLC38A2,SLC6A6,SLC7A1,SLC7A5,Slco1a1,SLCO1C1,SNAP23,SOCS2,SOSTDC1,STAT1,TGFA,THRB,TNFAIP6,TNFRSF18,TNFSF10,TRIB1,TRIM16,TRPM2,TXNIP,UBXN10,UCK2,WNT11,YPEL1 | 612 (18) |
| TP73 | -7.00e-01 | transcription regulator | NA | 6.80e-01 | 0.0e+00 | ABCB1,ADORA2B,AQP3,ARVCF,ATF3,BCL11B,BHLHE40,BMP7,BTG2,CASS4,CCL2,Ccl2,CCR9,CD83,CDKN1A,CXCL10,CXCL2,CXCL3,DDIT4,DMC1,EDN1,EPHA2,EREG,FASN,FOCAD,G0S2,GAB2,GADD45A,GRK5,HAPLN3,IER3,IL4R,ITGB7,KCNJ4,KCNK1,LAMA5,LIMK1,MISP,MYC,MYCN,NEXN,NRP1,NUPR1,PDGFB,PPL,PROCR,RFX2,SAT1,SDC4,SERPINE1,SFN,SHROOM4,SMO,SORBS3,SPTBN4,THBS1,TIMP1,TIMP3,TNFRSF12A,TP73 | 486 (18) |
| VEGFA | -4.50e-01 | growth factor | NA | 6.80e-01 | 0.0e+00 | ADAMTS1,ARG2,BCL2A1,BMP2,BTLA,CCL2,Ccl2,CD83,CDKN1A,CLDN5,CTSV,CXCL10,CXCL2,CXCL6,CXCR4,DLL1,EDN1,EXOC3L2,F3,FOS,HMOX1,IKBKE,JUNB,KDR,LAG3,MEOX2,MMP9,MYCN,NRP1,PDGFB,PLAT,PNPLA2,PTGS2,SELE,SERPINE1,SFTPB,TBC1D8,TFPI2,THBS1,TIMP1,XCL1 | 438 (18) |
| fenretinide | NA | chemical drug | NA | 6.80e-01 | 0.0e+00 | ACER2,ANKRD1,ATF3,ATF4,BCL2A1,GZMB,MMP9,MYC,NFKBIA,PRF1,PTGS2,STAT1,XPO1 | 366 (13) |
| NfkB1-RelA | NA | complex | NA | 6.70e-01 | 0.0e+00 | ADAMTS4,CCL2,CXCL3,IL12B,LCN2,MMP9,MUC5B,MYC,PTGS2,RGS16,SELE | 312 (9) |
| IL22 | NA | cytokine | NA | 6.70e-01 | 0.0e+00 | BCL2L1,CCL17,CCL4,CD274,CLCA1,CXCL10,CXCL2,CXCL3,CXCL6,FGA,HMOX1,IL12B,IL1A,IL24,IL33,KRT17,LCN2,MMP9,MUC5B,MYC,PFKFB3,PTGS2,S100A8,SOCS3 | 369 (19) |
| HMGB1 | NA | transcription regulator | NA | 6.70e-01 | 0.0e+00 | CCL2,CCL4,CD163,CD274,CD83,CDKN1A,CXCL2,CXCL3,CXCL6,FASN,FGL1,GLUL,IFIT1,IL1A,IRS1,MERTK,MMP9,MX1,PTGS2,SELE,TIMP3 | 385 (16) |
| E. coli serotype 0127B8 lipopolysaccharide | NA | chemical - endogenous non-mammalian | NA | 6.70e-01 | 0.0e+00 | Acot1,ADGRG2,ADORA1,AQP1,CCL17,CCL2,Ccl2,CCNO,CD14,CHST7,CXCL10,CXCL2,CXCR4,DIO2,EDEM1,EDNRA,F2RL1,FAM107A,GJB2,GLUL,GNAI2,HMOX1,IL12B,IL24,LCN2,LGALS3,LIF,LOX,MAP3K8,NFKBIA,P2RY14,PCK1,PDGFB,PPP1R1B,PTGS2,PTX3,RSAD2,SEMA7A,SLC16A9,SLC7A5,SOCS3,STAT1,TGFBR3 | 515 (16) |
| 3,3’-diindolylmethane | NA | chemical drug | NA | 6.70e-01 | 0.0e+00 | AR,ATF3,BCL2L1,CDKN1A,FASN,HMOX1,IFIT1,MAP1LC3B,NFKBIA,OAS2,PTGS2,TGFA | 470 (22) |
| caffeine | NA | chemical drug | NA | 6.70e-01 | 0.0e+00 | ADORA2A,CDKN1A,F3,FASN,FOS,HSD11B2,JUNB,PTGS2,SFTPB,THBS1,TP73 | 493 (21) |
| tetrachlorodibenzodioxin | NA | chemical toxicant | NA | 6.60e-01 | 0.0e+00 | ABCB1,ABCC2,ACER2,AQP3,AR,ARNT2,ATF4,BLK,CAP2,CD274,CDKN1A,CTSV,CUBN,CYP2S1,DCLK3,EDN1,ENC1,ERBB3,EREG,ESRRG,F3,FMO3,FOS,GADD45B,HMOX1,HUNK,HYAL2,IRS1,ITGA7,ITGB7,KCNA3,KCNA5,KCNJ5,KRT7,LPAR1,MGP,MYC,NEDD9,NR0B2,ODC1,PAX5,PCK1,Pcp4l1,PLAUR,PON1,PRKCB,PTGS2,S100A8,SAT1,SERPINE1,SERPINH1,SESN1,SFN,SHB,SHOX2,SLC38A3,SLC7A5,SOCS2,SOX2,TGFA,TGM1,THBS1,TNFRSF19,TNFSF8,TP73 | 512 (22) |
| DIO3 | 6.80e-01 | enzyme | NA | 6.60e-01 | 0.0e+00 | ADAMTS5,ADCYAP1R1,CIDEA,CIRBP,CLCA1,CLDN11,CTTNBP2,DHH,FGF11,INHBA,ITGA7,KCNH1,KCNJ11,MEOX2,MMP9,Nrgn,RBP4,SEMA7A,SLC16A4,SLC38A3,SPATA21,TBC1D30,TFR2,TRH | 323 (11) |
| MECP2 | 5.00e-02 | transcription regulator | NA | 6.60e-01 | 0.0e+00 | ABCB1,CAMK1D,CCNA1,EZH2,FKBP5,GALNT15,HCRTR1,JUNB,KCNF1,KCNJ6,MMD,Mt1,MYC,NEXN,PPP3R1,PRKCG,PTGS2,RASSF1,SCN4B,SLC6A2,SPN,TFPI2,TP53BP2,TXNIP | 390 (18) |
| mir-126 | 0.00e+00 | microRNA | NA | 6.60e-01 | 1.0e-02 | DLK1,IRS1,MYOCD,POU2AF1,PTPRC,SOX2 | NA |
| IGFBP3 | 3.80e-01 | other | NA | 6.60e-01 | 0.0e+00 | BCL2L1,CCL4,CDKN1A,COL2A1,LYVE1,MKNK2,SERPINE1,STAT1 | 416 (21) |
| GW7647 | NA | chemical drug | NA | 6.60e-01 | 0.0e+00 | CPT1A,CPT1B,HSD11B2,NPC2,PDK4,PPARA,SLC23A1 | 449 (17) |
| NFKBIZ | 3.80e-01 | transcription regulator | NA | 6.60e-01 | 0.0e+00 | CCL17,Ccl2,CEBPD,CXCL3,IL12B,LCN2,S100A8 | 498 (16) |
| hydrogen sulfide | NA | chemical - endogenous mammalian | NA | 6.60e-01 | 0.0e+00 | BCL2L1,CD69,HMOX1,PTGS2,SELL | 431 (20) |
| xanthine | NA | chemical - endogenous mammalian | NA | 6.60e-01 | 1.0e-02 | CD69,CXCR4,DUSP1,PLAUR | 454 (19) |
| KLF15 | 1.00e+00 | transcription regulator | NA | 6.50e-01 | 0.0e+00 | Acot1,CCL2,Ccl2,CPT1B,CXCL3,ESRRG,FABP3,FASN,PDK4,TNFSF10,TRIM63 | 481 (23) |
| ascorbic acid | NA | chemical - endogenous mammalian | NA | 6.50e-01 | 3.0e-02 | Acan,BCL2L1,CD40LG,CDKN1A,FTL,GLI1,MGP,NUPR1,PPARA,PTGS2,SERPINE1 | NA |
| (+)-MK-801 | NA | chemical drug | NA | 6.50e-01 | 0.0e+00 | ABCC2,CDKN1A,CREM,FOS,IL6R,ITGA2B,JUNB,NFKBIA,NGFR,PTGS2,SELL,TIMP1 | 500 (19) |
| SERPINC1 | -7.80e-01 | enzyme | NA | 6.50e-01 | 0.0e+00 | BCL2A1,F3,HK2,IL1A,PTGS2 | 476 (18) |
| CFB | 7.00e-02 | peptidase | NA | 6.50e-01 | 1.0e-02 | ACTC1,C3AR1,CR2,CXCL2,CXCL3,FASN | 207 (8) |
| TLR5 | 9.60e-01 | transmembrane receptor | NA | 6.50e-01 | 0.0e+00 | ATF3,Ccl2,CCL4,CXCL2,CXCL3,IL12B,IL1A,IL33 | 383 (16) |
| Stat6 dimer | NA | complex | NA | 6.50e-01 | 0.0e+00 | BCL2L1,CCL17,CLCA1,CXCL6,DUSP1,IL4R,IRF4,MAOA | NA |
| ANGPT1 | 5.00e-02 | growth factor | NA | 6.50e-01 | 0.0e+00 | ADAMTS1,ADAMTS4,ADAMTS5,ADAMTS9,BCL2L1,CCL2,DUSP1,SELE | 377 (17) |
| deoxycholate | NA | chemical - endogenous mammalian | NA | 6.50e-01 | 2.0e-02 | ABCB11,GJB2,GLUL,HK2,PLAUR,PTGS2,SLC10A1,TRPV1 | NA |
| SIRT6 | -4.00e-02 | enzyme | NA | 6.50e-01 | 5.0e-02 | ADGRE1,ANKRD1,Ccl2,FASN,IL1A,MMP9,PCK1,PTGS2,SERPINE1 | NA |
| FGF1 | -1.00e-01 | growth factor | NA | 6.40e-01 | 0.0e+00 | ADGRE1,ALB,Ccl2,CDKN1A,CR2,DLL1,EDN1,FOS,GADD45G,GCLC,HMOX1,Irgm1,IRS1,LRRC17,LTB,MYC,ODC1,PLG,PTGS2,SELE,SERPINB1,SGMS1,SOX2,THBS1,TIMP3,TNFRSF12A | 508 (19) |
| GLIS1 | 7.60e-01 | transcription regulator | NA | 6.40e-01 | 4.0e-02 | ADAMTS10,BMP2,LOXL1,TGM1,TIMP3 | NA |
| Vegf | NA | group | NA | 6.40e-01 | 0.0e+00 | ABCB1,ACKR4,Acot1,ADAMTS1,ADGRL2,ADORA2A,ATF3,AURKB,BCL2A1,BMP2,BMP7,C1QTNF1,CA4,CALCRL,Ccl2,CHST7,CIDEA,CXCL10,CXCL2,CXCR4,DDX11,DIO2,EDN1,EGR3,EPHA4,ERBB3,F3,FANCG,FKBP5,FOS,FOSL1,GEM,GJB2,GRB14,GRK5,HDC,HK2,HMOX1,IL12B,IL1A,INHBA,IRF4,KDR,LCN2,LPAR1,LYVE1,MAOB,MAP3K8,MEOX2,MGP,MMP9,MYC,MYCN,NR5A2,NRP1,OSMR,P2RY14,PDK4,PEMT,PGF,PLAUR,PPP1R1B,PRKCB,PTGS2,RAMP3,RGCC,SELE,SFN,SH3TC2,SLC7A1,SOCS2,SOCS3,TBC1D8,TCF23,TIMP1,TRIB1,XCR1,XDH | 464 (17) |
| POU2F2 | -1.17e+00 | transcription regulator | NA | 6.40e-01 | 0.0e+00 | ARG2,BANK1,BTLA,CD22,CD69,CD79B,FJX1,LCK,LRRC32,MS4A1,MYC,PFKFB3,POU2F2,TGFA,TNFRSF12A,TNFRSF21,ZDHHC23 | 217 (8) |
| pravastatin | NA | chemical drug | NA | 6.40e-01 | 0.0e+00 | ADCYAP1R1,APOB,CCL2,CRP,ENC1,HMOX1,PGF,PON1,PPARA,SDC4 | 332 (13) |
| LTB4R | 5.00e-02 | G-protein coupled receptor | NA | 6.40e-01 | 1.0e-02 | Ccl2,CLEC10A,CXCL2,CXCL3,MMP9,PTGS2 | 408 (18) |
| HAND1 | 7.00e-02 | transcription regulator | NA | 6.40e-01 | 1.0e-02 | CPT1A,EDN1,KDR,NRP1,OSR1,XCL1 | NA |
| TXNRD1 | 6.60e-01 | enzyme | NA | 6.40e-01 | 3.0e-02 | ABCC2,ACOX2,ESRRG,GCLC,HMOX1,LPIN1 | NA |
| potassium chloride | NA | chemical drug | NA | 6.40e-01 | 0.0e+00 | ATF3,ATP1A1,ATP1B1,ATP2B3,ATP2B4,BTG2,Ccl2,CIDEA,FOS,GNRH1,MYC,MYOCD,ODC1,PTGS2,RYR2,SLC7A1,TP73,TXNIP | 486 (21) |
| TLR2 | -5.10e-01 | transmembrane receptor | NA | 6.30e-01 | 0.0e+00 | ATF3,BMP2,CCL2,Ccl2,CCL4,CCR9,CD40LG,CD69,CDKN1A,CEBPD,CRP,CXCL10,CXCL2,CXCL3,CXCL6,DUSP1,FOS,GADD45A,HMOX1,IL12B,IL1A,IL33,ITGA2B,ITGB7,MMP9,MX1,PTGS2,PTX3,SELE,SELP,SOCS3,TBX21,TNFSF10,TRIM63 | 344 (15) |
| TET1 | -9.00e-01 | enzyme | NA | 6.30e-01 | 2.0e-02 | FOS,GCLC,Meis1,SFN,SOX2,TBX6 | NA |
| EFNA5 | -1.00e-01 | kinase | NA | 6.30e-01 | 0.0e+00 | ADAMTS4,EREG,FOSL1,KRT7,KRT75,PKP1,PLAT,PTGS2,TGM1,TNFAIP6 | 269 (7) |
| BTNL2 | NA | transmembrane receptor | NA | 6.30e-01 | 1.0e-02 | ACSBG1,CYP2S1,GBP4,GJB2,NTRK3,SELL,SEMA4F,SPECC1,TNFSF10,XDH | NA |
| CNTF | 3.40e-01 | cytokine | NA | 6.30e-01 | 0.0e+00 | ADGRE1,ATF3,C3AR1,Ccl2,CD14,CD69,CEBPD,CRP,CXCR4,DISP1,FASN,FOS,HMOX1,IL1A,IRS1,JUNB,KCNJ6,LCN2,LGALS3,LIF,NGFR,Oasl2,OSMR,PDE10A,PPP1R1B,PTGER3,PTGS2,SLC11A1,SLC13A3,SOCS2,SOCS3,STAT1,TIMP1,WNT5A,XDH,ZFP36 | 354 (16) |
| KDM3A | 7.00e-02 | transcription regulator | NA | 6.30e-01 | 0.0e+00 | AR,ARHGEF28,CCL2,EDN1,FSTL3,HMOX1,IL33,MCAM,MMP9,MYC,PPP1R3C,SERPINE1 | 238 (7) |
| AGER | 3.00e-01 | transmembrane receptor | NA | 6.30e-01 | 0.0e+00 | CCL2,Ccl2,CCL4,CD40LG,CDKN1A,CXCL2,CXCL3,F3,IFIT1,IL4R,MMP9,PDGFB,PTGS2,S100A8,SELE,SELENBP1,SERPINE1,TXNIP | 388 (16) |
| PRKAA | NA | group | NA | 6.30e-01 | 0.0e+00 | AR,Ccl2,CDKN1A,CPT1A,CXCL10,DUSP1,FASN,FKBP5,PCK1,STAT1 | 515 (23) |
| CD209 | NA | other | NA | 6.20e-01 | 1.0e-02 | CCL4,CLDN5,MMP9,PTGS2 | 340 (17) |
| carfilzomib | NA | biologic drug | NA | 6.20e-01 | 4.0e-02 | ATF3,ATF4,ERN1,MYC | NA |
| ITGB3 | -1.70e-01 | transmembrane receptor | NA | 6.20e-01 | 0.0e+00 | BCL2L1,CD274,CD40LG,FOS,ITGA2B,KDR,MMP9,PLAUR,PTGS2,SELP,SERPINE1,TIMP1 | 357 (16) |
| NR1H2 | 1.20e-01 | ligand-dependent nuclear receptor | NA | 6.10e-01 | 0.0e+00 | APCS,AQP1,Ccl2,CCL4,CIDEA,CRP,CXCL10,CXCL2,DIO2,FASN,GBP4,GLI1,MMP9,NFKBIA,PNPLA2,PTGS2,THRB,TRH | 455 (24) |
| MALP-2s | NA | chemical reagent | NA | 6.10e-01 | 0.0e+00 | BCL2A1,CCL4,CXCL2,CXCL3,IL12B,IL1A,PTGS2 | 312 (13) |
| diethylstilbestrol | NA | chemical drug | NA | 6.10e-01 | 0.0e+00 | ADCYAP1R1,ADH1C,AQP3,AR,AURKB,CD14,CD83,CDKN1A,CXCL6,Elf5,ENDOU,EREG,F3,FGFBP1,FOS,GABRP,GADD45A,GAL,GJB2,HDC,IL1R2,IL4R,INHBA,IRS1,ITIH4,KDR,LARP6,LMO4,MAOA,MGP,MMP8,MOXD1,PDGFB,PGLYRP1,S100A8,SEZ6,SFN,SIX1,Slpi/Slpil2,SOCS2,TGFA,Tlr12,WNT5A,WNT7A | 540 (20) |
| CUX1 | 2.30e-01 | transcription regulator | NA | 6.10e-01 | 0.0e+00 | CDKN1A,CXCL10,CXCL2,CXCL3,CXCL6,LILRB3,MMP8,MYC,THBS1,WNT5A | 353 (15) |
| SERPINB7 | 4.00e-02 | other | NA | 6.10e-01 | 0.0e+00 | ADAMTS15,ADAMTS4,CALCRL,CCL2,CTSH,CTSW,CXCL2,CXCL3,DHH,GNAI2,INHBA,MMP9,S100A8,TGM1,TLL1,TRPV1,USP43 | NA |
| PLAUR | 1.33e+00 | transmembrane receptor | NA | 6.00e-01 | 0.0e+00 | BCL2L1,CCL2,Ccl2,CXCL3,FOSL1,JUNB,KDR,MMP9,MYC,PLAUR,PLG | 401 (20) |
| UCP1 | -1.30e-01 | transporter | NA | 6.00e-01 | 0.0e+00 | ADGRE1,ANKRD1,ASB2,ATF4,CTSV,CXCL10,ERN1,ESRRG,FASN,GADD45A,MYC,NUPR1,ODC1,OTUB2,PCK1,PSAT1,SERPINE1,STBD1,TPPP,UBC | 478 (20) |
| IRS2 | 2.70e-01 | enzyme | NA | 6.00e-01 | 0.0e+00 | DNASE1L3,FASN,FOS,HMOX1,IRS1,MX1,MYC,PCK1 | 530 (21) |
| SAMSN1 | -5.60e-01 | other | NA | 6.00e-01 | 0.0e+00 | ARID5A,CCL4,CMPK2,CXCL10,CXCL2,EDN1,FCER2,HDC,IL12B,INHBA,ISG15,LMO4,LTA,MERTK,Mx2,PLA1A,PLAT,PTGS2,RGCC,RILPL1,RSAD2,SOCS3,STAT1,TNFSF8,ZC3H12A | 271 (7) |
| PLA2G6 | 1.70e-01 | enzyme | NA | 6.00e-01 | 1.0e-02 | ARG2,ATF4,BCL2L1,Ccl2,PTGS2 | 434 (19) |
| gossypol | NA | chemical drug | NA | 5.90e-01 | 0.0e+00 | ATF3,ATF4,BCL2L1,SAT1 | 337 (7) |
| PLCG2 | -1.40e-01 | enzyme | NA | 5.90e-01 | 1.0e-02 | BCL2A1,CCL2,Ccl2,CTSV,CXCL10,ISG15,PTGS2,PTPRC,STAT1,TNFSF10 | 414 (17) |
| DDX17 | NA | enzyme | NA | 5.90e-01 | 1.0e-02 | CDKN1A,FOSL1,LCN2,MYC | NA |
| CSF2 | 1.50e-01 | cytokine | NA | 5.90e-01 | 0.0e+00 | ADGRE5,ADORA2B,AOC1,BCL2A1,BCL2L1,CA4,CCL17,CCL2,Ccl2,CCL4,CD101,CD14,CD163,CD180,CD28,CD40LG,CD69,CD83,CD8A,CDKN1A,CIITA,CREB1,CX3CR1,CXCL10,CXCL2,CXCL3,CXCR4,DOK2,EDN1,EGR3,F2RL1,F3,FOS,FOSL1,HDC,HK2,HMOX1,IER3,IFRD1,IL12B,IL1A,IL24,INHBA,IRF4,JUNB,LTA,LTB,MMD,MMP8,MMP9,MYC,NFKBIA,NRP1,ODC1,OSMR,PLAUR,PNPLA1,PTGS2,RBM3,Retnlg,RGCC,SNAP23,SNTB1,SOCS2,SOCS3,SPHK1,THBS1,TLR5,TNFRSF18,TNFSF8,UPP1,ZFP36 | 514 (17) |
| EPAS1 | 3.70e-01 | transcription regulator | NA | 5.90e-01 | 0.0e+00 | ARG2,BHLHE40,CA12,CD274,CDKN1A,CEMIP,CKMT1A/CKMT1B,CXCL2,CXCR4,EDN1,FASN,FOS,GADD45B,IL2RB,ITGA2B,KDR,LAG3,LOX,MAFF,NFIL3,NRN1,PDGFB,PFKFB3,PGF,PRF1,RASSF1,SERPINE1,SFTPB,SLC16A4,SLC7A5,SOX2,SPHK1,TGFA,TNFRSF8 | 465 (21) |
| LGALS1 | -1.10e-01 | other | NA | 5.90e-01 | 0.0e+00 | ADAMTS4,Ccl2,CD69,CDKN1A,CXCL2,DISP1,F3,GLI1,IL1A,LGALS3,MMP9,PTX3,SERPINE1,SOCS3 | 438 (15) |
| PTAFR | -8.00e-02 | G-protein coupled receptor | NA | 5.80e-01 | 0.0e+00 | CCL2,CXCL2,MCAM,MMP9,MYC,PTGS2 | 415 (17) |
| TG | 2.00e-01 | other | NA | 5.80e-01 | 1.0e-02 | CPT1A,DIO1,IL1R2,PDK4,THRB,TRH | 189 (7) |
| decitabine | NA | chemical drug | NA | 5.80e-01 | 0.0e+00 | ABCB1,ABCC2,ADAMTS1,ADCY5,ADGRL2,ANKRD1,AR,BAIAP2,BCL11A,BMP6,CA12,CAP2,Ccl2,CCNA1,CCR3,CCR6,CD79B,CD8A,CDCA7,CDH6,CDKN1A,CDO1,CLDN5,CREB1,CX3CR1,CXCL10,CXCL3,CXCR4,DKK2,DNASE1L3,DUSP1,EGR3,FLRT3,FOXC1,FUBP1,GADD45B,GADD45G,GJB1,GPAT2,GPR37,HK2,HNF4A,IGSF9,IRX1,ISG15,JUNB,KRT7,KRT75,LGALS3,LOX,MAOB,MMP9,MX1,MYC,NFKBIA,NKX2-8,OGT,PDGFB,PKNOX2,PSAT1,PTGS2,RASSF1,RASSF10,SAT1,SELL,SERPINH1,SEZ6L,SFN,SFTPB,SLC43A1,SLC7A1,SMO,SOCS3,SPOCK1,STAT1,STEAP2,SYT1,TFPI2,THBS1,TIMP3,TLL1,TNFSF10,TP53BP2,TP73,WNT5A,WNT7A,XCL1,XPO1 | 570 (21) |
| CIDEC | -3.00e-01 | other | NA | 5.80e-01 | 0.0e+00 | CCL2,Ccl2,CIDEA,CPT1A,CPT1B,DIO2,FASN,PNPLA2,PPARA,PPARGC1B,SERPINE1 | 479 (22) |
| BMAL1 | NA | transcription regulator | NA | 5.80e-01 | 0.0e+00 | ADORA2B,Ccl2,FASN,GNRH1,HK2,HMOX1,NFIL3,PER1,PPARA,PPARGC1B,RYR2 | 446 (18) |
| XDH | 6.40e-01 | enzyme | NA | 5.80e-01 | 0.0e+00 | Ccl2,CD69,CXCL3,CXCR4,DUSP1,F3,PLAUR,PPARA,SERPINE1 | 366 (15) |
| 8-chlorophenylthio-adenosine 3’,5’-cyclic monophosphate | NA | chemical reagent | NA | 5.80e-01 | 0.0e+00 | CDKN1A,CEBPD,CPT1B,CREM,DUSP1,HSD17B2,LPIN1,LPIN2,PCK1,S100A8 | 545 (24) |
| FGF19 | NA | growth factor | NA | 5.80e-01 | 0.0e+00 | BCL2L1,CXCL2,Cyp4a14,CYP7B1,ENO3,FABP3,FASN,FOS,G0S2,GADD45A,LCN2,MCAM,NR0B2,PON1,PPARGC1B,RGS16,SCN1B,SLC2A5 | 466 (22) |
| lysophosphatidylinositol | NA | chemical - endogenous mammalian | NA | 5.80e-01 | 0.0e+00 | CCL2,CD274,CPT1A,CXCL3,CXCL6,F3,GLUL,IL1A,IL33,LTB,SELE,SGPP2 | 492 (16) |
| SFRP5 | 6.00e-02 | transmembrane receptor | NA | 5.80e-01 | 0.0e+00 | CCL2,Ccl2,CXCR4,PTGS2 | 310 (11) |
| CFLAR | 3.60e-01 | other | NA | 5.80e-01 | 2.0e-02 | BCL2L1,CDKN1A,FOS,HMOX1,ISG15 | NA |
| STAT2 | -1.10e-01 | transcription regulator | NA | 5.80e-01 | 0.0e+00 | CCL19,Ccl2,CIITA,CXCL10,GLI1,IFIT1,IFITM2,ISG15,MX1,OAS2,Oasl2,RSAD2,SOCS3,STAT1,TNFSF10,USP18,ZBP1 | 378 (17) |
| DETA-NONOate | NA | chemical reagent | NA | 5.70e-01 | 0.0e+00 | BCL2L1,CDKN1A,CXCL3,DUSP1,FOS,HMOX1,MMP9,MYC,ODC1,PTGS2,S100A8,SERPINE1,TIMP1,TP73,TXNIP | 412 (16) |
| CDK6 | -1.40e-01 | kinase | NA | 5.70e-01 | 0.0e+00 | ABCB1,EREG,FGF11,FOS,GADD45A,INHBA,IPMK,MAP2K6,NGFR,PPARA,PRKCB,PTGS2,SERPINE1,SLCO1C1,SOCS3,TGFA | 513 (24) |
| CTSB | 2.40e-01 | peptidase | NA | 5.70e-01 | 0.0e+00 | CTSV,CXCL2,CXCL3,KDR,MYC,PLAUR,SPHK1 | 516 (21) |
| POSTN | 0.00e+00 | other | NA | 5.70e-01 | 0.0e+00 | ADAMTS4,ATF4,Ccl2,CLCA1,DLK1,LOX,LOXL1,MMP9,MYC,PDGFB | 428 (20) |
| Stat3-Stat3 | NA | complex | NA | 5.60e-01 | 0.0e+00 | APCS,BCL2L1,CDKN1A,CRP,FCER2,FGA,FOS,FTL,IL4R,LTA,MAOA,MYC,SOCS3,TIMP3,WNT5A | 494 (18) |
| HAS2 | -2.60e-01 | enzyme | NA | 5.60e-01 | 0.0e+00 | Ccl2,HAS1,HYAL2,LOX,LYVE1,MMP9,TIMP1,TNFAIP6 | 189 (7) |
| CLU | 3.00e-02 | other | NA | 5.60e-01 | 0.0e+00 | BCL2L1,CCL2,CDKN1A,GBP5,GBP7,MMP9,NFKBIA,STAT1,XDH | 462 (18) |
| glucosamine | NA | chemical - endogenous mammalian | NA | 5.60e-01 | 0.0e+00 | APOB,CCL2,CXCL3,FASN,IL24,OGT,PCK1,PTGS2,TGFA,TXNIP | 515 (24) |
| abemaciclib | NA | chemical drug | NA | 5.60e-01 | 4.0e-02 | F9,ISG15,LIF,PLAT,TGFA | NA |
| RC3H2 | -8.00e-02 | enzyme | NA | 5.60e-01 | 2.0e-02 | CCL2,CCR6,EDN1,NRP1,PGF,PLG | NA |
| BGLAP | NA | other | NA | 5.60e-01 | 0.0e+00 | ADGRE1,CIITA,CYP2R1,DIO2,DLK1 | NA |
| CRKL | NA | kinase | NA | 5.60e-01 | 0.0e+00 | CXCL10,HDC,LTA,PLA1A,RILPL1 | NA |
| triadimefon | NA | chemical toxicant | NA | 5.60e-01 | 2.0e-02 | ABCB1,ADH1C,Cyp3a25 (includes others),Cyp4a14,POR,SLC6A13,UGT2A1 | NA |
| JINK1/2 | NA | group | NA | 5.60e-01 | 2.0e-02 | Ccl2,FASN,IL1A,PLG,PTGS2 | NA |
| letrozole | NA | chemical drug | NA | 5.60e-01 | 3.0e-02 | AGR2,CDKN1A,FOSL1,LIF,MYC | NA |
| PAK1 | 1.90e-01 | kinase | NA | 5.60e-01 | 4.0e-02 | CDKN1A,F3,FOSL1,MMP9,MYC | NA |
| buthionine sulfoximine | NA | chemical drug | NA | 5.50e-01 | 0.0e+00 | ABCB1,BCL2L1,CD274,CXCR4,FOS,HMOX1,HSD11B2,NFKBIA,PTGS2,SERPINE1 | 345 (13) |
| HOXA5 | -1.60e-01 | transcription regulator | NA | 5.50e-01 | 0.0e+00 | CDKN1A,CXCL6,GADD45B,LIF,LTA,NFKBIA,PTGS2,PTX3,SAT1,SLC6A2 | NA |
| TFAP2C | NA | transcription regulator | NA | 5.50e-01 | 0.0e+00 | CA12,CDKN1A,EGR3,FOXC1,KRT81,Meis1,MMP9,MYC,NRP1,TGFA,THBS1,TIMP1 | 480 (15) |
| taurocholic acid | NA | chemical - endogenous mammalian | NA | 5.50e-01 | 0.0e+00 | ATF3,CCL2,Ccl2,GADD45B,KDR,LPIN2,NR0B2,PPARA,PTGS2 | 509 (22) |
| sphingosine-1-phosphate | NA | chemical - endogenous mammalian | NA | 5.50e-01 | 0.0e+00 | ACER2,ACKR4,CCL2,Ccl2,CCR3,CD274,CD83,CXCL10,CXCL2,ERN1,FOS,GALNT15,GBP5,KDR,MEOX1,MMP9,NRP1,PDGFB,PPARGC1B,PTGS2,SELE,SERPINE1,SPHK1,ST8SIA2,THBS1,TIMP1,WNT11 | 435 (17) |
| DNMT3A | -5.10e-01 | enzyme | NA | 5.50e-01 | 0.0e+00 | ACTC1,ADAMTS9,ADCY5,ADORA1,Akap17b,AKAP6,ATF3,ATP2B4,CD19,CD79A,CD79B,CXCL2,CXCL3,CXCR4,CYSLTR1,EDNRA,GRINA,IRS1,Mt1,PAX5,PIK3C2B,POU2AF1,PPP1R3A,PPP1R3C,PPP3R1,PRKCB,PTGS2,PTPRC,RGS16,RYR2,S100A8,SDC4,SERPINH1,SOCS3,SPHK1,TLR5 | 494 (21) |
| BMP4 | -3.30e-01 | growth factor | NA | 5.50e-01 | 0.0e+00 | BMP2,CCL19,CDKN1A,COL2A1,CXXC5,DIO2,GABRP,HK2,INHBA,JUNB,KDR,KRT7,MYC,MYCN,NGFR,NUPR1,OVOL2,PFKFB3,PGF,PRKCB,PRKCH,SERPINE1,SLC13A4,SLC38A3,SOX2,SPNS2,WNT5A | 584 (19) |
| GW3965 | NA | chemical reagent | NA | 5.40e-01 | 0.0e+00 | ANGPTL3,ARG2,Ccl2,CCL4,CRP,CX3CR1,CXCL10,DUSP1,EDNRA,FASN,GADD45G,IER3,IL12B,LPIN1,MERTK,MMP9,NFKBIA,NR5A2,PDK4,PTGER3,PTGS2,SOCS3,TRIB1 | 394 (22) |
| CSF1R | -2.70e-01 | kinase | NA | 5.40e-01 | 0.0e+00 | ADGRE1,Adgre4,CD163,Cd209b,CDKN1A,FOS,HMOX1,IL1A,IL22RA2,IL4R,JUNB,MMP9,MYC | 421 (19) |
| SMARCA4 | -3.00e-02 | transcription regulator | NA | 5.40e-01 | 0.0e+00 | ABCB1,AGR2,ALB,ATP2B4,AZGP1,BCL2A1,CCL2,CCR6,CD19,CDKN1A,CIITA,CTSH,CXCR4,DLL1,DYSF,EDNRA,ENO3,EPHA4,EREG,ESPNL,F3,FGFBP1,FKBP5,FOS,FOSL2,GADD45A,GADD45B,GADD45G,GCLC,GLI1,GULP1,HAPLN3,HNF4A,IER3,IFIT1,IFITM2,IL1A,INHBA,ITGA7,KDR,KHDRBS3,LGALS3,LOX,LRRC34,MAFF,MAOB,MC5R,MGP,Mt1,MYBPH,MYC,NPC2,NRIP3,NRP1,PGM2L1,PKIA,PLAT,PLAUR,Pmaip1,PTX3,RASSF1,SEMA7A,SERPINE1,SERPINH1,SFTPB,SLC11A1,SLC43A3,SOCS2,SOX2,SPHK1,STAMBPL1,TBX21,TMEM171,TNFRSF14,TNFSF10,TRIM15,TXNRD1,WNT7A | 493 (22) |
| MED1 | -1.10e-01 | transcription regulator | NA | 5.40e-01 | 0.0e+00 | ADCY5,ANO2,AOC1,APOB,AURKB,BCL11A,BCL2L1,BHLHE40,CD79A,CD79B,CDKN1A,CIDEA,Cyp4a14,DIO1,DYSF,FASN,GADD45A,IL2RB,IRF4,LIF,MYC,MYCN,NFKBIA,ODC1,OTUB2,PDK4,PEX11A,POU2AF1,PRKCH,SOX2,TBX21,TET1,THBS1,WDR72 | 543 (20) |
| OLFM4-RET | NA | fusion gene/product | NA | 5.40e-01 | 0.0e+00 | ATP1B4,CCL2,CCL4,CPA2,EGR3,FOS,FOSL1,GZMB,IL24,JUNB,KRT17,MYCT1,SLC26A3,TMPRSS4 | 350 (14) |
| miR-146a-5p (and other miRNAs w/seed GAGAACU) | NA | mature microRNA | NA | 5.30e-01 | 0.0e+00 | CCL2,Ccl2,CCR3,CRP,CXCL3,CXCR4,IRAK2,LTB,MMP16,NFKBIA,PGLYRP1,PRF1,SDCBP2,STAT1,SYT1,TBX21,TLR10,TRIM14 | 410 (12) |
| butyric acid | NA | chemical - endogenous mammalian | NA | 5.30e-01 | 0.0e+00 | ABCB1,ABCC2,ADGRE1,ADGRE5,AFF1,ALB,AQP1,AR,ATP2B4,BCL2A1,BCL2L1,CBS/LOC102724560,CCR3,CD14,CD300C,CD79B,CD83,CDKN1A,CXCR4,DUSP1,ELK3,F10,FASN,FOS,G0S2,GADD45A,GATA5,GBP2,GCLC,GLI1,GNAI2,IFIT1,IFITM2,IL12B,IL24,IRS1,ITGB7,MMP9,MPP3,MYC,MYCN,NFKBIA,NRP1,OAS2,PAX5,PCK1,PLAT,POU2F2,PPARA,PRKCB,PTGS2,PTPRN,SAT1,SERPINE1,SOCS3,SPOCK1,TGM1,TIMP1,TIMP3,TP53BP2,TRPV1,WNT5A | 498 (15) |
| daunorubicin | NA | chemical drug | NA | 5.30e-01 | 4.0e-02 | ABCB1,BCL2L1,CDKN1A,MYC,PTGS2 | NA |
| GPNMB | 3.10e-01 | enzyme | NA | 5.30e-01 | 2.0e-02 | APCDD1,FOS,IL12B,MYC,NRP1 | NA |
| SP2509 | NA | chemical reagent | NA | 5.20e-01 | 3.0e-02 | ADAMTS1,ANKRD1,AR,BAIAP2,BCL11A,CAP2,CD274,CDCA7,CREB1,CXCL10,FLRT3,FOXC1,FUBP1,IGSF9,LOX,MYC,OGT,PSAT1,SLC43A1,SLC7A1,SMO,SPOCK1,STEAP2,SYT1,XPO1 | NA |
| IPMK | 6.10e-01 | kinase | NA | 5.20e-01 | 2.0e-02 | CCR10,FOS,IRF4,JUNB,LAG3,MYC,PER1 | NA |
| DBP | -2.70e-01 | transcription regulator | NA | 5.20e-01 | 2.0e-02 | ADH1C,F9,PER1,PPARA | NA |
| CITED2 | 2.10e-01 | transcription regulator | NA | 5.20e-01 | 0.0e+00 | ARL4A,CCL2,Ccl2,CD274,CD69,CLEC10A,CMPK2,CXCL10,CXCL2,CXCL3,DNASE1L3,DUSP1,ENDOD1,F3,GADD45B,GBP2,GBP4,GBP5,IFI44,IFRD1,IL12B,IL1A,Irgm1,ISG15,Klrk1,KYNU,Mx2,Oasl2,P2RY14,PFKFB3,RSAD2,SAT1,SLC28A2,SLC38A2,TMEM171,TREML2,UPP1,ZBP1 | 345 (15) |
| LDLR | 3.30e-01 | transporter | NA | 5.20e-01 | 0.0e+00 | APOB,AURKB,BCL2L1,BMP2,CCL2,Ccl2,CCL4,CCR3,CD274,CD40LG,CDKN1A,CPT1B,CX3CR1,CYP7B1,DUSP1,F3,FABP3,FASN,GADD45G,H6PD,HK2,IER3,IL12B,IL1A,LAG3,LCN2,LY86,MERTK,MMP9,MYC,PCK1,PPARA,SELE,TRIB1,UBC,WNT7A,ZBP1 | 520 (18) |
| selenium | NA | chemical drug | NA | 5.20e-01 | 3.0e-02 | AR,CDKN1A,PTGS2,SELP,TXNRD1 | NA |
| BCL2L1 | 1.35e+00 | other | NA | 5.20e-01 | 0.0e+00 | BCL2L1,Ccl2,CD19,CXCL3,LTA,MMP9,PTPRC,SPN,THBS1,TIMP1,TNFRSF21,TNFSF10,TNFSF8 | 521 (16) |
| TRIM31 | NA | enzyme | NA | 5.10e-01 | 0.0e+00 | CDKN1A,CPT1A,FASN,PDK4,PPARA | 338 (7) |
| NFATC1 | -1.00e-01 | transcription regulator | NA | 5.10e-01 | 0.0e+00 | ATF3,BMP7,CCR9,CD3G,CD40LG,CX3CR1,EDN1,EGR3,FCER2,GLI1,HMOX1,HNF4A,IL12B,IL33,KCNJ11,MYC,POU2AF1,PPP3R1,PTGS2,SELL,SLAMF6,TBX21,THBS1,TNFSF10 | 464 (19) |
| IL17RA | 7.00e-02 | transmembrane receptor | NA | 5.10e-01 | 0.0e+00 | Ccl2,CCL28,CSF3R,CXCL2,CXCL3,CXCL6,IL1A,MMP9,S100A8,SELE,SELP,TIMP1 | 356 (19) |
| EGLN1 | 9.00e-02 | enzyme | NA | 5.10e-01 | 0.0e+00 | Acan,ADAMTS5,Ccl2,COL2A1,CXCR4,DLL1,EDN1,IL1A,INHBA,MMP8,MYC,PTGS2,SDC4,SELL | 425 (18) |
| NR4A3 | 5.40e-01 | ligand-dependent nuclear receptor | NA | 5.10e-01 | 0.0e+00 | ADGRE1,Ccl2,CD300C,CD5L,CDKN1A,CTHRC1,CXCL3,ENO3,LPIN1,PPARGC1B,SERPINE1,TBX6 | 465 (20) |
| PLD2 | -4.00e-02 | enzyme | NA | 5.10e-01 | 4.0e-02 | ABCB11,CIDEA,DIO2,PTGS2 | NA |
| DICER1 | -6.00e-02 | enzyme | NA | 5.10e-01 | 0.0e+00 | CDKN1A,CRYM,CXCL10,CXCR4,EGR3,FOS,GZMB,KDR,Klrk1,MCAM,MMP9,MYC,NGFR,PRF1,PROCR,PTPRN,RASGRP1,RBFOX1,RGCC,SCN10A,SERPINE1,SERTAD4,SOCS3,SOX2,SPN,STAT1,THBS1,TRPC3,WNT5A,WNT7A,ZEB2 | 507 (21) |
| diethylmaleate | NA | chemical toxicant | NA | 5.10e-01 | 0.0e+00 | CDKN1A,Gsta1,HMOX1,NFKBIA,SELE | 367 (12) |
| N(G)-monomethyl-D-arginine | NA | chemical - endogenous mammalian | NA | 5.00e-01 | 0.0e+00 | CD8A,CXCL3,FOS,HMOX1,IL12B,MMP9,PLAUR,PTGS2,SELP | 310 (16) |
| SYK | -4.30e-01 | kinase | NA | 5.00e-01 | 0.0e+00 | ARID5A,CCL2,CCL4,CD40LG,CD69,CREB1,CREM,CXCL10,CXCR4,EDN1,FCMR,FOSL1,GADD45A,GIMAP7,GLI1,KLHL31,OAS2,RGCC,TFPI2,TNFSF10 | 513 (16) |
| NPC1 | -6.00e-02 | transporter | NA | 5.00e-01 | 0.0e+00 | ACKR4,APOB,ATF4,CCR3,CD22,CD79B,CD8A,CTSH,CX3CR1,LGALS3,MERTK,MMP8,NPC2,OSBPL3,PNPLA3,PTGS2,S100A8,STAT1,TMEM119 | 441 (22) |
| ALOX15 | -1.70e-01 | enzyme | NA | 5.00e-01 | 1.0e-02 | Ccl2,CCL4,CXCL2,FOSL1,HMOX1,IL12B,IL1A | 398 (17) |
| lactic acid | NA | chemical - endogenous mammalian | NA | 5.00e-01 | 1.0e-02 | CCL17,CCL2,CXCL10,KDR,PCK1,PRF1,SLC16A3 | 458 (17) |
| SOX3 | NA | transcription regulator | NA | 5.00e-01 | 0.0e+00 | APCDD1,BMPER,DLL1,DUSP1,EPHA2,GBP4,INHBA,IRS1,NRP1,Oasl2,SOX2,TNFRSF19,TXNRD1,USP18,WNT5A,ZBTB16 | NA |
| mycophenolic acid | NA | chemical drug | NA | 5.00e-01 | 0.0e+00 | ATF3,AZGP1,CCL2,CD274,CDKN1A,CXCL3,CXCL6,CXCR4,DUSP1,EDN1,INHBA,KRT17,MGAM,PTGS2,SERPINE1 | 413 (17) |
| NDRG1 | 3.10e-01 | kinase | NA | 5.00e-01 | 0.0e+00 | AR,ATF3,CXCL2,CXCL3,ERBB3,ERRFI1,FOS,GLI1,IL1A,MAP1LC3B,MYC | 479 (21) |
| CASP8 | -2.30e-01 | peptidase | NA | 4.90e-01 | 0.0e+00 | CCL17,CD14,CD69,CXCL10,FOS,IL12B,IL1A,IL33,ISG15,MMP9 | 346 (18) |
| IRF4 | -1.17e+00 | transcription regulator | NA | 4.90e-01 | 0.0e+00 | ATF4,CCL17,Ccl2,CD28,CIITA,CX3CR1,CXCL10,CXCL3,CXCR4,ERBB3,FCER2,ICA1,IL12B,IL33,IRF4,ISG15,MS4A1,MYC,PAX5,PLAUR,PROCR,STAT1,STK17B,TBX21,TNFRSF8,TNFSF10,XCL1 | 471 (17) |
| mir-181 | NA | microRNA | NA | 4.90e-01 | 0.0e+00 | AR,CD163,CD40LG,CD69,CDKN1A,CREB1,EZH2,PTGS2,SLC47A1,TBX21,TIMP3,ZEB2 | 382 (15) |
| selenite | NA | chemical toxicant | NA | 4.90e-01 | 0.0e+00 | BCL2L1,MMP9,Mt1,TIMP1,TP73 | 455 (18) |
| ST8SIA1 | -7.50e-01 | enzyme | NA | 4.90e-01 | 0.0e+00 | C3AR1,CDKN1A,IL1A,MMP9,SOX2 | 531 (23) |
| LHCGR | NA | G-protein coupled receptor | NA | 4.90e-01 | 0.0e+00 | ADAMTS1,AR,CTSV,GNRH1,IL1R2,PTGS2,TNFAIP6 | 488 (19) |
| Mir200 | NA | group | NA | 4.90e-01 | 1.0e-02 | EZH2,LOX,SERPINH1,SOX2,ZEB2 | NA |
| bezafibrate | NA | chemical drug | NA | 4.80e-01 | 0.0e+00 | ABCB11,Acot1,CPT1B,CREB3L3,CRP,Cyp4a14,DLK1,FASN,HNF4A,LGALS3,NPC2,PDK4,PEX11A,PPARA,PTGS2,SERPINE1 | 521 (21) |
| OPRK1 | -1.60e-01 | G-protein coupled receptor | NA | 4.80e-01 | 0.0e+00 | FOS,KDR,NRP1,PLXND1 | 364 (11) |
| F3 | 1.20e+00 | transmembrane receptor | NA | 4.80e-01 | 0.0e+00 | CCL2,Ccl2,CCNA1,DUSP9,F3,FOS,MAPKAPK3,MMP9,SELE,SERPINC1,SERPINE1 | 366 (15) |
| UPF2 | 9.00e-02 | other | NA | 4.80e-01 | 1.0e-02 | CXCL10,KHDRBS3,KLHL41,NRP1,PTGS2,TFR2 | NA |
| NOTCH1 | 1.70e-01 | transcription regulator | NA | 4.80e-01 | 0.0e+00 | ANKRD1,AQP3,ASB2,BCL2L1,BMP2,CD14,CD84,CDCA7,CDKN1A,CEBPD,CXCR4,DLK1,DLL1,EPHA4,ERBB3,FOS,FOSL1,GLI1,HEYL,HK2,HMOX1,IL12B,IL1A,ITGA2B,LOX,LYVE1,MCAM,MYC,MYCN,NGFR,PDGFB,PFKFB3,PTGS2,RND3,SELE,SERPINE1,SOX2,TGFBR3,TREM3,WNT5A | 476 (16) |
| OSMR | 7.80e-01 | transmembrane receptor | NA | 4.80e-01 | 0.0e+00 | ADGRE1,ALB,Ccl2,CXCL10,CXCL2,FASN,FOS,GBP2,GBP4,GBP5,Igtp,IL6R,Irgm1,JUNB,Mx2,Oasl2,OSMR,SOCS3,TIMP1,ZFP36 | 417 (22) |
| 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene | NA | chemical toxicant | NA | 4.80e-01 | 0.0e+00 | ABCC2,APCS,CDKN1A,CPT1A,CPT1B,CYP7B1,DIO1,DIO2,FASN,GADD45B,MAFF,Mt1,NEDD9,PCK1,PNPLA2,PPARA,SAT1,Slco1a1,SLCO1C1 | 482 (20) |
| TRADD | -1.20e-01 | other | NA | 4.80e-01 | 0.0e+00 | AR,BCL2A1,CCL2,CXCL2,CXCL3,MMP9,NFKBIA | 328 (12) |
| baicalein | NA | chemical drug | NA | 4.80e-01 | 1.0e-02 | ABCB1,BCL2L1,CCL2,FOS,HMOX1,KDR,PTGS2 | NA |
| LEPR | -1.40e-01 | transmembrane receptor | NA | 4.80e-01 | 0.0e+00 | ADGRE1,APOB,ATF3,BCL2L1,Ccl2,EDN1,FASN,FOS,GADD45B,GADD45G,GNRH1,HPX,IL1R2,IL24,LCN2,LIF,PPARA,SELE,SERPINE1,SOCS2,SOCS3,SOX2,STK17B,TIMP1,TIMP3,TRH,TRPV1 | 434 (18) |
| TSHZ3 | 4.70e-01 | transcription regulator | NA | 4.80e-01 | 0.0e+00 | CRYM,CXXC5,FOSL2,KCNG1,NGFR,NTRK3,PTGER3,RAMP3,SPSB1,TXNIP | NA |
| STK11 | 2.10e-01 | kinase | NA | 4.70e-01 | 0.0e+00 | ALB,ATF3,CCL2,Ccl2,CD274,CDKN1A,CSF3R,CXCL2,CXCL3,CXCL6,EREG,FOSL1,GADD45A,GADD45B,GFI1,GLI1,IL1A,IL2RB,IL33,JUNB,KCNA2,KLF12,LTB,MCAM,MMP9,MYC,NEDD9,PSAT1,PTGS2,PTPRN,RASGRP1,RASSF1,SERPINE1,SLC16A4,SMO,STK17B,TGFA,TNFRSF18,TNFSF10,TXNRD1,UCK2,VIPR2,WNT5A | 517 (18) |
| isotretinoin | NA | biologic drug | NA | 4.70e-01 | 0.0e+00 | BCL2L1,CCL2,CD19,CDKN1A,FASN,IL12B,LCN2,MMP9,NGFR,ODC1,PTGS2,SPN,TMPRSS4,TNFSF10 | 457 (19) |
| PTCH1 | -3.00e-01 | transmembrane receptor | NA | 4.70e-01 | 0.0e+00 | BTG2,COL2A1,DLL1,GADD45A,GLI1,IL33,MYCN | 331 (6) |
| APEX1 | 4.00e-01 | enzyme | NA | 4.70e-01 | 0.0e+00 | ABCB1,CDKN1A,EGR3,FOS,IL1A,JUNB,PTGS2 | 503 (22) |
| uric acid | NA | chemical - endogenous mammalian | NA | 4.70e-01 | 0.0e+00 | CCL2,Ccl2,CCL4,CCNA1,CRP,CXCL2,CXCL3,HMOX1,IL12B,IL1A,ISG15,PTGS2,RSAD2,S100A8,USP18 | 291 (17) |
| IRF6 | 1.40e-01 | transcription regulator | NA | 4.70e-01 | 0.0e+00 | ADAMTS5,CCL2,CD14,CD274,CD69,CLEC10A,IL12B,LCN2,PPARGC1B,PTGS2 | 348 (15) |
| hemin | NA | chemical - endogenous mammalian | NA | 4.60e-01 | 0.0e+00 | BCL2L1,Ccl2,CD163,CDKN1A,CX3CR1,FTL,HMOX1,HPX,IL12B,IL33,NFYA,PROCR,PTGS2 | 363 (20) |
| F2RL1 | 7.80e-01 | G-protein coupled receptor | NA | 4.50e-01 | 0.0e+00 | AGR2,ATF3,CCL2,CXCL2,F2RL1,F3,FOS,GBP2,GBP4,IL1A,IL4R,ITGA7,LIF,MMP9,OSMR,PTGS2,SERPINB1,STK32A,TGFA,TRPA1,TXNIP | 410 (19) |
| ARID1A | -2.40e-01 | transcription regulator | NA | 4.50e-01 | 0.0e+00 | ARVCF,CD274,CD83,CDKN1A,Clec2e/Clec2h,CXCL2,ERBB3,EREG,FGFBP1,FZD9,IKZF3,IL1A,KRT17,KRT7,MIEF2,MKKS,P4HA1,P4HA2,PEX11A,PIK3IP1,PLXND1,RNF144A,SOX2,WNT5A,ZFPM2 | 524 (19) |
| fingolimod phosphate | NA | chemical - endogenous mammalian | NA | 4.50e-01 | 0.0e+00 | CCL2,ERN1,SERPINE1,SPHK1,THBS1 | 286 (12) |
| Gm20703 | NA | other | NA | 4.50e-01 | 0.0e+00 | CD69,CXCL10,GBP5,IFIT1,IL1A | 216 (7) |
| NF 449 | NA | chemical reagent | NA | 4.50e-01 | 0.0e+00 | CCL4,GLI1,GZMB,MYCN,PRF1 | NA |
| mannose | NA | chemical - endogenous mammalian | NA | 4.50e-01 | 0.0e+00 | ATF4,BCL2L1,FASN,FOS,THBS1 | 542 (22) |
| C2CD5 | -1.10e-01 | other | NA | 4.50e-01 | 0.0e+00 | CIDEA,CPT1A,DIO2,PNPLA2,TMEM26 | NA |
| HCAR1 | -1.00e+00 | G-protein coupled receptor | NA | 4.50e-01 | 1.0e-02 | CXCR4,EDN1,HK2,NEDD9,SLC16A3 | 235 (7) |
| myclobutanil | NA | chemical toxicant | NA | 4.50e-01 | 1.0e-02 | ABCB1,ADH1C,Cyp3a25 (includes others),Cyp4a14,POR,SLC6A13,UGT2A1 | NA |
| ZNF217 | -2.00e-02 | transcription regulator | NA | 4.50e-01 | 1.0e-02 | AGR2,CCL2,ERBB3,KCNK2,MYC,MYCN,PIPOX,PLAT,SEC14L2,SOCS2 | NA |
| miR-205-5p (and other miRNAs w/seed CCUUCAU) | NA | mature microRNA | NA | 4.50e-01 | 1.0e-02 | ABCC2,ATP1A1,ERBB3,MMP9,ZEB2 | NA |
| xanthine derivative CB002 analog 4 | NA | chemical reagent | NA | 4.50e-01 | 2.0e-02 | APOB,DPYSL5,GADD45A,PNKD,SERPINE1 | NA |
| ASXL2 | -3.20e-01 | other | NA | 4.50e-01 | 2.0e-02 | G0S2,HK2,KLF15,PPARGC1B,SERPINE1 | NA |
| ELOVL5 | 1.00e-02 | enzyme | NA | 4.50e-01 | 2.0e-02 | Acot1,FASN,PCK1,PDK4,PNPLA2 | NA |
| ELL2 | 4.90e-01 | transcription regulator | NA | 4.50e-01 | 4.0e-02 | CRELD2,EDEM1,IRF4,MYC,POU2AF1,RAPGEF3,TRIB1 | NA |
| GSR | 2.00e-02 | enzyme | NA | 4.50e-01 | 4.0e-02 | ABCC2,ACOX2,GCLC,HMOX1,LPIN1 | NA |
| NAMPT | 4.80e-01 | cytokine | NA | 4.50e-01 | 0.0e+00 | ALDH8A1,CCR3,CXCL10,CXCL2,EPHA2,FMO3,HMOX1,HSD17B2,MMP9,NELL2,POR,SOCS2,WNT5A | 476 (17) |
| MST1 | 5.70e-01 | growth factor | NA | 4.40e-01 | 0.0e+00 | BCL2L1,FOS,IL12B,NR0B2,PCK1,PTGS2 | 452 (19) |
| CHAF1A | 2.30e-01 | other | NA | 4.40e-01 | 0.0e+00 | Elf5,NGFR,ODC1,SAT1,SOX2 | 158 (5) |
| CTLA4 | -6.00e-02 | transmembrane receptor | NA | 4.40e-01 | 0.0e+00 | CBLB,CD69,CD83,CXCL10,FAR2,GZMB,LAG3,SELE,SELP,SLC7A5 | 411 (16) |
| SKI | -1.30e-01 | transcription regulator | NA | 4.40e-01 | 0.0e+00 | BCL11B,CDKN1A,GLI1,Nes,ODC1,SERPINE1,ZEB2 | 467 (21) |
| GMNN | -2.50e-01 | transcription regulator | NA | 4.30e-01 | 0.0e+00 | APCDD1,BMPER,CDKN1A,DUSP1,EPHA2,GBP4,INHBA,IRS1,NRP1,Oasl2,SOX2,TNFRSF19,TXNRD1,USP18,WNT5A | 438 (12) |
| Calcineurin protein(s) | NA | complex | NA | 4.30e-01 | 0.0e+00 | CBLB,CCL4,CPT1B,CTSV,CXCL3,DUSP1,FOS,LIN7A,NFIL3,PPARA,PTGS2,Rcan1,SERPINE1 | 480 (22) |
| NR5A2 | -8.10e-01 | ligand-dependent nuclear receptor | NA | 4.30e-01 | 0.0e+00 | ABCB11,ABCC2,BAAT,C3AR1,CCL28,CDKN1A,CEBPD,CPA2,CRP,CXCL10,CYP7B1,FASN,FOS,GADD45G,HNF4A,IL12B,IL24,JUNB,MMP9,Mt1,MYC,NR0B2,NR5A2,SLC10A1,TNFRSF12A,TNFSF10 | 467 (23) |
| vismodegib | NA | chemical drug | NA | 4.30e-01 | 0.0e+00 | ADGRE1,CCL2,Ccl2,CD14,GLI1,IL1A,IL33,LGALS3,PTGER3,SOX2,TNFSF10 | 295 (7) |
| NFKB1 | 2.00e-02 | transcription regulator | NA | 4.30e-01 | 0.0e+00 | ABCB1,ADORA1,ANKRD1,AR,BCL2A1,BCL2L1,BHLHE40,BLK,BMP2,BTG2,CCL17,CCL19,CCL2,Ccl2,CCL4,CD274,CD3G,CD83,CDKN1A,CIITA,COL2A1,CR2,CRP,CXCL10,CXCL2,CXCL3,DUSP1,FOS,GADD45A,GRK5,HMOX1,IER3,IKBKE,IL12B,IL1A,IRF4,ISG15,LTA,LTB,MAP3K8,MMP9,MYC,NFKBIA,POU2F2,PTGS2,PTX3,SDC4,SELE,SELP,STAT1,TBX21,TNFRSF18,TNFSF10 | 496 (15) |
| tacrolimus | NA | chemical drug | NA | 4.20e-01 | 0.0e+00 | ABLIM1,ATP2B4,BCL2L1,CCL2,Ccl2,CCL4,CCR3,COL2A1,CXCL10,CXCL2,CXCR4,DAB2IP,DACH1,DPYSL5,EDN1,ENC1,FKBP5,FOS,GZMA,GZMB,IL1R2,IL2RB,IL33,IRF4,ITGB7,JUNB,KLRD1,LRRC32,MYC,NFKBIA,NRP1,ODC1,OSBPL3,PRF1,PTGS2,Rcan1,RCN1,SELL,TGFBR3,TLE3,TNFRSF12A,TNFRSF18,TNFSF10,TRPM6,WNT7A,XCL1,XCR1 | 501 (14) |
| PRKCQ | -3.80e-01 | kinase | NA | 4.20e-01 | 0.0e+00 | BCL2L1,CD69,CDKN1A,FOSL1,IL24,MMP9,PRKCB,PRKCH,TBX21 | 396 (20) |
| MAPK1 | -2.00e-02 | kinase | NA | 4.20e-01 | 0.0e+00 | ADH1C,AR,ARG2,ATF3,ATP1B1,BCL11A,CCL2,CCL4,CD69,CD84,CDKN1A,CHST7,CTSW,DUSP1,ENDOD1,ENO3,F9,FAT2,FCMR,FOS,FOSL2,GBP2,GBP5,HDC,HMOX1,HSD17B2,IFI44,IFIT1,IGSF9B,ISG15,ITGA2B,JUNB,KRT17,LAG3,LGALS3,LIF,LOX,MAOB,MMP9,MYC,NRN1,NRP1,NUPR1,OAS2,OSBPL3,PDGFB,PDLIM3,POU2F2,PRMT8,PSAT1,PTGS2,RGS16,SERPINE1,SLITRK6,SOCS2,SPOCK1,SPSB1,STAT1,TBX21,TNFSF10,TRIM14,USP18,ZNF184 | 492 (20) |
| 3-methyladenine | NA | chemical toxicant | NA | 4.20e-01 | 0.0e+00 | ADAMTS5,AGR2,CXCL2,HMOX1,IL12B,IL33,MAP1LC3B,PTGS2,SOX2,TP73 | 385 (15) |
| CCND1 | -5.70e-01 | transcription regulator | NA | 4.20e-01 | 0.0e+00 | AQP3,AR,AZGP1,BHMT2,CCNA1,CDCA7,CDKN1A,DKK2,ENDOD1,EPGN,EPHA2,EREG,ERRFI1,GJB1,IER3,Klra2,MAFF,MYC,MYRIP,OVOL2,PDLIM3,PTPRC,RCN1,ROR2,SELENBP1,SOX2,ST6GALNAC5,STBD1,TBCK,THNSL1,WNT7A | 490 (24) |
| SKP2 | 1.00e-02 | other | NA | 4.20e-01 | 2.0e-02 | CDKN1A,EZH2,ODC1,TP73,USP18,ZEB2 | NA |
| MRTFB | NA | transcription regulator | NA | 4.20e-01 | 0.0e+00 | ABLIM1,ADAMTS1,ANKRD1,BBOX1,BCL2L1,CXCL6,CXCR4,EDN1,EDNRA,EGR3,FCN1,FIBIN,FJX1,G0S2,GADD45A,GFI1,GPR37,INHBA,KAZN,LCN2,LOXL1,PGLYRP1,PTGS2,PTPRO,RPS6KA6,S100A8,SELP,SERPINE1,THBS1,WNT5A,YPEL1 | 253 (10) |
| zerumbone | NA | chemical - endogenous non-mammalian | NA | 4.20e-01 | 0.0e+00 | ATF4,BCL2A1,BCL2L1,HMOX1,MMP9,MYC,PTGS2 | 395 (14) |
| IKZF1 | NA | transcription regulator | NA | 4.10e-01 | 0.0e+00 | AQP1,BCL2L1,C1QTNF1,CCL19,CCL4,CD79B,CD8A,CDKN1A,CXCL2,CYP7B1,EIF4E3,EPB42,FGFR4,HK2,IL1A,IL2RB,IRF4,ITGA2B,LCK,LILRB3,MYC,NGFR,PAX5,POU2F2,RAPGEF4,RNF213,SERPINH1,SPN,SPSB1,TBX21,TMEM119,TXNIP,ZNF710 | 548 (20) |
| 11,12-epoxyeicosatrienoic acid | NA | chemical - endogenous mammalian | NA | 4.10e-01 | 0.0e+00 | DUSP1,MMP9,NFKBIA,PLAT,SELE | 354 (15) |
| CCR1 | 1.10e-01 | G-protein coupled receptor | NA | 4.10e-01 | 2.0e-02 | ATF4,Ccl2,CTSV,FOS,MMP9 | NA |
| CCR5 | -5.10e-01 | G-protein coupled receptor | NA | 4.10e-01 | 0.0e+00 | Ccl2,CCL4,CD40LG,CXCL10,CXCL2,CXCL3,F3,FOS,IL12B,MMP9 | 322 (16) |
| CD40LG | -7.50e-01 | cytokine | NA | 4.10e-01 | 0.0e+00 | ATF3,BCL2A1,BCL2L1,CCL17,CCL19,CCL2,CCL4,CD27,CD40LG,CD69,CD83,CD8A,CDKN1A,CIITA,CXCL10,CXCL2,CXCR4,DUSP1,F3,FCER2,FOS,FOSL2,G0S2,GADD45A,GZMB,HK2,IFI44,IFIT1,IL12B,IL1A,IL21R,IL24,IL2RB,IL4R,INHBA,IRF4,ISG15,ITGB7,JUNB,LTA,LTB,MX1,MYC,NFKBIA,PLAUR,PTGS2,SELE,SELL,SELP,SERPINE1,SLC23A1,STAT1,TNFAIP6,TNFRSF13C,TNFSF10,TNFSF8,WNT5A | 509 (17) |
| TFAP2A | 3.00e-02 | transcription regulator | NA | 4.10e-01 | 0.0e+00 | ADRA1D,BCL2L1,CCL28,CDKN1A,CHRNA7,CXCL2,EREG,EZH2,FGFR4,GEM,GNRH1,GPR37,IL12B,MMP9,PLAUR,POR,SERPINE1,SESN1,TIMP1 | 433 (20) |
| carbenoxolone | NA | chemical toxicant | NA | 4.00e-01 | 0.0e+00 | EDN3,FASN,HSD11B2,LOX,MMP9,PTGS2,TIMP1 | 470 (19) |
| TERT | -4.60e-01 | enzyme | NA | 4.00e-01 | 0.0e+00 | AR,ATF3,CCL17,CCL2,CCL24,CDKN1A,CXCL10,CXCL2,CXCL6,ELK3,EREG,IFI44,IFIT1,ISG15,MMP9,MX1,Mx2,MYC,NFKBIA,OAS2,Oasl2,PCDHGA1,PTGS2,TIMP1,TNFSF8 | 315 (19) |
| SAR1B | 1.80e-01 | enzyme | NA | 4.00e-01 | 1.0e-02 | APOB,CPT1A,FASN,PPARA | NA |
| mir-27 | NA | microRNA | NA | 4.00e-01 | 1.0e-02 | ABCB1,BMP2,CLDN5,EDN1,EDNRA,FASN,PNPLA2,PNPLA3,PPARA,PTGS2 | 483 (19) |
| NFKBIB | 5.40e-01 | transcription regulator | NA | 3.90e-01 | 0.0e+00 | BCL2A1,BCL2L1,CCL2,CTSV,CXCL2,GNAI2,MMP9,NFKBIA,SELE,TNFSF10,TP73 | 298 (14) |
| Ro41-5253 | NA | chemical reagent | NA | 3.90e-01 | 1.0e-02 | CDKN1A,F3,PLAT,SLC10A1,SMPD3 | 168 (5) |
| XRCC5 | -1.50e-01 | enzyme | NA | 3.90e-01 | 0.0e+00 | CD274,CXCL10,FASN,MCAM,Mt1,PTGS2,XDH | 287 (7) |
| FCER1G | -2.00e-02 | transmembrane receptor | NA | 3.90e-01 | 2.0e-02 | CCL4,CD69,IL12B,MX1,PTGS2,RSAD2 | NA |
| PRKCA | -1.50e-01 | kinase | NA | 3.90e-01 | 0.0e+00 | BCL11A,BCL2L1,CCL2,CDKN1A,CIITA,CXCL10,CXCL2,CXCL3,FASN,FOS,IFIT1,MMP9,MYC,NFKBIA,PTGS2,RSAD2,S100A8,SELP,SERPINE1 | 407 (14) |
| tanshinone II | NA | chemical - endogenous non-mammalian | NA | 3.90e-01 | 0.0e+00 | AR,ATF3,BCL2L1,CCL2,EDN1,FOS,GJB2,HMOX1,MMP9 | 394 (15) |
| E2F3 | 2.80e-01 | transcription regulator | NA | 3.90e-01 | 0.0e+00 | CA12,CCNA1,CDKN1A,ECE1,EDN1,EZH2,INHBA,KRT80,MYC,MYCN,PPP1R13B,PTGER3,S100A8,SERPINE1,SERPINH1,THBS1,TIMP3,TP53BP2,TP73 | 437 (16) |
| 17-alpha-ethinylestradiol | NA | chemical drug | NA | 3.90e-01 | 0.0e+00 | ABCB1,ABCB11,ABCC2,ADGRE1,ADGRE5,APOB,AQP3,ARRDC3,ATF4,Ccl2,CCR3,CD5L,CDKN1A,CXCL10,CXCL3,CXCL6,CYP7B1,F3,FOS,KRT7,LCN2,LPIN1,LY86,MMP9,NR0B2,ODC1,SERPINH1,SESN1,SFN,SLC10A1,SLC11A1,SLC38A3,Slco1a1,SLCO1C1,TNFSF8 | 626 (20) |
| PTPN22 | -4.60e-01 | phosphatase | NA | 3.90e-01 | 0.0e+00 | CD274,CREM,FOS,IRF4,ISG15,LAG3,OSMR,TNFRSF18 | 343 (14) |
| ZBTB7B | 2.00e-01 | transcription regulator | NA | 3.90e-01 | 4.0e-02 | CCR6,CD8A,COL2A1,CPT1B,DIO2,IL2RB,NRP1,PRF1 | NA |
| IL1RN | -3.00e-02 | cytokine | NA | 3.80e-01 | 0.0e+00 | ATF3,CCL2,CDKN1A,CIITA,CXCL3,H6PD,IFI44,IFI44L,IL1A,LIF,MMP9,MX1,NR0B2,OAS2,PTGS2,RSAD2,SELE,SERPINE1,TIMP1,TNFSF10,USP18,ZNF81 | 417 (15) |
| 26s Proteasome | NA | complex | NA | 3.80e-01 | 0.0e+00 | AR,BMP2,CCL2,CDKN1A,CXCL3,EREG,FOSL1,JUNB,MAP1LC3B,MLF1,MYC,Pmaip1,PTGS2,SFTPB,SOCS3,SOX2,STAT1,TNFSF10,TXNIP | 504 (20) |
| ADCYAP1 | 2.90e-01 | other | NA | 3.80e-01 | 0.0e+00 | ADCYAP1R1,BMP6,BTG2,Ccl2,CCL4,CEBPD,CREB1,CXCL10,CXCL2,CXCL3,DIO2,EFHC1,EGR3,EPHA2,FOS,GLI1,GNRH1,GRK5,IER3,IL12B,MCAM,MYC,NFKBIA,NPR3,PDE10A,POR,RAB3IP,RGCC,SERPINB1,SEZ6L,SOCS3,TRH,TXNRD1 | 378 (18) |
| EZH2 | -6.60e-01 | transcription regulator | NA | 3.80e-01 | 0.0e+00 | AADAT,ATF3,BCL11A,BCL11B,BCL2L1,BMP2,BMP7,Ccl2,CDKN1A,CEMIP,CRISPLD2,CSF3R,CXCL10,CXCL2,CXCR4,DAB2IP,DNAH2,EZH2,FGF11,FKBP5,GATA5,HSD11B2,IL12B,IL24,IL6R,KCNK1,KRT81,LCN2,LTB,MAPK15,MMP9,MYC,NFKBIA,NGFR,NKD2,NME5,PCDH20,PDGFB,PER1,PGF,PIK3IP1,PPP2R2B,PTGS2,S100A8,SFN,SOCS3,TBX21,TGFA,TGFBR3,TIMP3,ZBTB16 | 478 (21) |
| PRLR | -3.60e-01 | transmembrane receptor | NA | 3.80e-01 | 4.0e-02 | CDKN1A,Elf5,EZH2,GJB1,MYC | NA |
| PGLYRP2 | -4.40e-01 | transmembrane receptor | NA | 3.80e-01 | 0.0e+00 | CCL17,CCL19,CCL2,Ccl2,CCL4,CXCL2,CXCL6 | 297 (14) |
| SOCS6 | -2.00e-02 | other | NA | 3.80e-01 | 0.0e+00 | CEBPD,CXCL2,CXCL3,PLA1A,PLAT,PTGS2,RGCC | 359 (9) |
| TLN1 | 3.00e-02 | other | NA | 3.80e-01 | 0.0e+00 | Ccl2,CCL4,CD14,CXCL10,GBP2,IL1A,MMP9 | 404 (17) |
| CHADL | -2.90e-01 | other | NA | 3.80e-01 | 0.0e+00 | Ccl2,CDKN1A,COL2A1,FAM107A,NTRK3,PTX3,SMPD3 | NA |
| PTN | -1.40e-01 | growth factor | NA | 3.80e-01 | 4.0e-02 | APOB,CPT1A,DLK1,FASN,LPIN2,PDHA1,PPARA | NA |
| PLAG1 | -3.80e-01 | transcription regulator | NA | 3.80e-01 | 4.0e-02 | AQP1,CD300C,CDC42EP4,GJB1,KCNJ4,LILRB3,SRPK3 | NA |
| DNMT3B | -2.00e-02 | enzyme | NA | 3.80e-01 | 0.0e+00 | ACTC1,ADCY5,ADORA1,CDKN1A,EDNRA,EZH2,GATA5,IFIT1,JAKMIP2,KDR,LONRF1,LRRC34,MYC,PIK3C2B,PNPLA3,PPP1R3A,PPP1R3C,PRKCB,PRUNE2,RASSF1,RGS16,RYR2,STAT1,TIMP3,TRPC3 | 386 (14) |
| IRAK4 | -5.00e-02 | kinase | NA | 3.80e-01 | 0.0e+00 | ATF3,BTG2,CCL17,Ccl2,CSRNP1,CXCL10,CXCL2,CXCL3,CXCL6,EDN1,ERRFI1,FOS,GEM,IFRD1,IL12B,IRF4,LIF,MAP3K8,NFKBIA,NOCT,RGS16,ZC3H12A,ZFP36 | 465 (15) |
| lithium chloride | NA | chemical drug | NA | 3.70e-01 | 0.0e+00 | AR,BMP2,BMP7,CDKN1A,DLK1,EZH2,FOS,GFI1,HEYL,HMOX1,MAP1LC3B,MYC,NKD2,PER1,PTGS2,PTX3,TNFSF10 | 435 (19) |
| SLC15A4 | -4.50e-01 | transporter | NA | 3.70e-01 | 0.0e+00 | ADAMTS1,ANXA3,BCL2A1,CBLB,CCL2,CD274,CRELD2,CXCL10,EDEM1,EZH2,FOS,GBP4,GBP5,HMOX1,IFIT1,KRT17,LGALS3,LOXL1,Oasl2,PBK,PLAUR,PTGS2,SAT1,TNFAIP6,TPBG,USP18 | 466 (22) |
| chitin | NA | chemical - endogenous non-mammalian | NA | 3.70e-01 | 2.0e-02 | CCL17,Ccl2,CD274,IL33 | NA |
| N-acetylmuramyl-L-alanyl-D-isoglutamine | NA | chemical - endogenous non-mammalian | NA | 3.70e-01 | 0.0e+00 | CCL17,CCL19,CCL2,Ccl2,CCL4,CXCL2,CXCL3,CXCL6,IL12B,IL1A,MMP9,NFKBIA,PTGS2 | 319 (14) |
| IL18 | 2.60e-01 | cytokine | NA | 3.70e-01 | 0.0e+00 | ADAMTS5,AQP3,ATF3,BCL2L1,CCL2,Ccl2,CCL4,CD163,CD40LG,CD69,CD83,CHRNA7,CX3CR1,CXCL10,CXCL3,DDIT4,FOSL2,GADD45B,GADD45G,GIMAP4,GZMA,GZMB,GZMM,IL1A,IL22RA2,LIF,LTB,MMP9,NFIL3,PRF1,PTGS2,SELL,SERPINB1,SOCS2,TBX21,TIMP1,XCL1 | 543 (17) |
| oblimersen | NA | biologic drug | NA | 3.70e-01 | 0.0e+00 | ATF3,BCL2L1,CDKN1A,CEBPD,DUSP1,GADD45A,GADD45B,IFI44,IFIT1,IFRD1,IL24,ISG15,MAFF,MX1,OAS2,RSAD2,SIX1,STAT1,TRIM14 | NA |
| TO-901317 | NA | chemical reagent | NA | 3.70e-01 | 0.0e+00 | Acot1,ADH1C,ALB,ANGPTL3,APCS,ARG2,BCL2L1,C9,CCL2,Ccl2,CCL24,CD5L,CIDEA,CPT1A,CRP,Cyp4a14,CYP7B1,DIO1,DNASE1L3,FASN,HK2,ITIH4,LGALS3,MMP9,Mt1,NFKBIA,NR0B2,NR5A2,PCK1,PFKFB3,PGLYRP1,PNPLA3,POR,PTGER3,PTGS2,TIMP1,TIMP3 | 486 (21) |
| valproic acid | NA | chemical drug | NA | 3.70e-01 | 0.0e+00 | AR,ATF3,ATF4,ATP2B4,BCL2L1,CA12,CAP2,CCL2,CD83,CDCA7,CDKN1A,CPT1A,CXCR4,CYP2R1,Cyp4a14,EDEM1,EDN1,ERN1,FAM107A,FOXC1,GADD45B,GLUL,GNAI2,GZMB,H6PD,HMOX1,IL1A,MS4A1,MYCN,NFYA,NPC2,NR0B2,PDGFB,PLAT,PNPLA2,PNPLA3,PPARA,PTGS2,PTX3,RCL1,RERG,RNF144A,SERPINE1,SERPINH1,SMIM3,SOX2,THBS1,THRB,TNFSF10,TP73,WNT5A | 477 (19) |
| TSLP | -3.00e-01 | cytokine | NA | 3.70e-01 | 0.0e+00 | BPIFB1,CCL17,CD83,GJB1,IL12B,MAP1LC3B,MUC5B,MX1,MYC,SELE,SELL,SELP,SOX2,TIMP1 | 394 (19) |
| KAT2A | -2.30e-01 | enzyme | NA | 3.70e-01 | 0.0e+00 | ADAMTS1,ADAMTS5,BCL11A,BCL11B,BCL2L1,CD19,CDCA7,CLDN11,EDEM1,EZH2,GABARAPL1,GCLC,JUNB,NGFR,PCK1,PTPRO,SHOX2,SYT1,TRIM63,XPO1 | 409 (13) |
| CREBBP | -4.00e-02 | transcription regulator | NA | 3.60e-01 | 0.0e+00 | ADORA2A,AR,ARID5A,BANK1,BMP7,CAMK1G,CDKN1A,COL2A1,CRISPLD2,CXCL10,CXCR4,DUSP1,EGR3,FGL1,FOS,FOSL2,GFI1,GIMAP4,GIMAP7,GLI1,GRIN2D,Gsta1,IL2RB,ISG15,ITGB7,KCNIP3,LTA,MAP3K8,MMP9,MYC,NFKBIA,NTRK3,PCK1,PDE10A,PIPOX,PPM1E,PRF1,PTGS2,RAPGEF3,RAPGEF4,RNF39,RSAD2,SCN4B,SDC4,SELE,SELP,SFTPB,SLAMF6,SLC43A1,SMPD3,SOCS3,SPSB1,TESC,TMPRSS4,TNFSF10,USP18,WNT7A | 455 (17) |
| IL9 | NA | cytokine | NA | 3.60e-01 | 2.0e-02 | CCL2,Ccl2,GZMB,ITGA2B,JUNB,MYC,PRF1,SCIN | NA |
| miR-199a-5p (and other miRNAs w/seed CCAGUGU) | NA | mature microRNA | NA | 3.60e-01 | 0.0e+00 | CDKN1A,CMPK2,ISG15,KRT17,LCN2,MYOCD,NEDD9,PTGS2,RSAD2,TGFBR3,WNT7A,ZBP1,ZBTB16 | 273 (7) |
| PRDM16 | -8.00e-02 | transcription regulator | NA | 3.60e-01 | 0.0e+00 | CDKN1A,CIDEA,CXCL10,DIO2,GADD45G,GBP4,IFI44,Mx2,OAS2,SERPINE1,STAT1 | 400 (20) |
| KLF3 | 4.00e-02 | transcription regulator | NA | 3.50e-01 | 0.0e+00 | Acot1,ARID5A,ATF4,BTLA,CCL24,CCL28,CD69,CIRBP,CMPK2,CXCL2,CXCL3,EIF4E3,EXTL1,FCER2,FOS,GFI1,GPR174,ITGB7,JOSD2,KLF12,LILRB3,LTA,PIK3IP1,RASSF1,SELL,SERPINH1,SLC28A2,SLC6A13,TNFRSF21,TNFSF10,TNFSF8,TP53I13,ZEB2 | 409 (7) |
| luteolin | NA | chemical drug | NA | 3.50e-01 | 0.0e+00 | APOB,AR,BCL2L1,CXCL10,FOS,GCLC,HMOX1,HNF4A,IL12B,IRS1,MMP9,MYC,PTGS2,SELE | 390 (15) |
| GADD45A | 7.00e-01 | other | NA | 3.50e-01 | 1.0e-02 | BCL2L1,CDKN1A,CXCL2,CXCL3,MMP9 | 487 (20) |
| hymecromone | NA | chemical drug | NA | 3.50e-01 | 1.0e-02 | ADAMTS4,BCL2L1,CXCR4,HAS3,MMP9,TNFAIP6 | 401 (16) |
| SUMO1 | 2.60e-01 | enzyme | NA | 3.50e-01 | 1.0e-02 | ABCB11,ALB,CXCL10,MYC,NR0B2,PTGS2 | NA |
| FGFR2 | -2.70e-01 | kinase | NA | 3.50e-01 | 1.0e-02 | BMPER,CA4,CD274,CDKN1A,CTSH,CUBN,DLL1,FLRT3,IL1A,KBTBD11,MYC,NR5A2,PLAUR,SOX2,SOX7 | 402 (18) |
| AGN194204 | NA | chemical drug | NA | 3.50e-01 | 0.0e+00 | Acot1,ATF3,ATP1A1,BCL2A1,CCL4,CDKN1A,CPT1A,CYP26B1,Cyp4a14,CYP7B1,DKK2,DUSP1,ENO3,EZH2,F2RL1,GADD45A,GBP2,GFI1,HK2,Igtp,IL1R2,IL2RB,IL33,IL4R,ITGB7,KRT80,LTA,MMP9,MYC,NPC2,PDK4,PPL,RAMP3,SCIN,SNTB1,SPN,TIMP1 | 401 (18) |
| SULF2 | 3.30e-01 | enzyme | NA | 3.50e-01 | 0.0e+00 | Acan,ADAMTS5,COL2A1,GLI1,MMP9,PDGFB,SOCS2,SOCS3 | 434 (18) |
| CD44 | -1.00e-01 | other | NA | 3.40e-01 | 0.0e+00 | ABCB1,ADGRE1,BCL2L1,CCL19,Ccl2,CCL4,CD274,CD69,CD8A,CDKN1A,CIDEA,CX3CR1,CXCL6,F3,FASN,FKBP5,GADD45A,HAS3,IFITM2,IL1A,IL1R2,LGALS3,LIMS2,MMP8,MMP9,MYC,PDK4,PFKFB3,PGM2L1,PPARA,SBK1,SDC4,SELL,SOX2,THBS1,WNT5A,XCL1 | 557 (19) |
| CDKN1B | -4.00e-02 | kinase | NA | 3.40e-01 | 0.0e+00 | ADGRE5,APCDD1,BCL11A,C9,CCNA1,CDKN1A,DHH,DUSP9,EPHA2,GAB2,LGALS3,MMP16,MMP9,MYC,PAX5,RYR2,SERPINE1,SOX2 | 556 (24) |
| GLI2 | -4.10e-01 | transcription regulator | NA | 3.40e-01 | 0.0e+00 | BCL2L1,CCL17,CCL24,CCL4,CD40LG,CDKN1A,CXCL10,CXCL2,CXCL3,CXCL6,GLI1,HK2,HSD11B2,IFITM5,IL6R,JUNB,KRT17,MEOX1,MMP9,MYC,MYCN,PFKFB3,PRKCH,SMO,TGFA,WNT5A | 568 (28) |
| MEN1 | 3.20e-01 | transcription regulator | NA | 3.40e-01 | 0.0e+00 | AR,CDKN1A,EZH2,FKBP5,FOS,FOXC1,GLI1,Meis1,MYC | 460 (23) |
| SATB2 | -3.40e-01 | transcription regulator | NA | 3.40e-01 | 3.0e-02 | BCL11B,CDH6,CXCL10,IFI44,MMP16,PRRX1,TNFSF8 | NA |
| CBFB | -1.70e-01 | transcription regulator | NA | 3.40e-01 | 0.0e+00 | ATF4,CCR6,IKZF3,IL2RB,ITGA2B,KCNK5,MMP9,NRP1,RAB3IP,SOCS2,TBX21,TGFBR3,TNFRSF18 | 446 (16) |
| farnesyl pyrophosphate | NA | chemical - endogenous mammalian | NA | 3.40e-01 | 1.0e-02 | FASN,PTGS2,SELP,SERPINE1 | 489 (19) |
| PDGF-AA | NA | complex | NA | 3.40e-01 | 1.0e-02 | CDKN1A,EREG,FOS,ID4,SOX2 | NA |
| COP1 | NA | enzyme | NA | 3.40e-01 | 0.0e+00 | AR,CA12,CD69,CDKN1A,CXCL10,CXCL3,CYP26B1,EGR3,FOS,IL12B,KAZN,KCNK5,OVOL2,PEX11A | 471 (20) |
| EWSR1-FLI1 | NA | fusion gene/product | NA | 3.40e-01 | 0.0e+00 | BBOX1,BCL2L1,CDKN1A,EDN1,EDNRA,EGR3,FIBIN,FJX1,GPR37,IL1A,KAZN,LOXL1,PTPRO,SERPINE1,THBS1,YPEL1 | 286 (10) |
| ZNF281 | -9.00e-02 | transcription regulator | NA | 3.30e-01 | 0.0e+00 | CCL2,CCL24,CCL4,CXCL2,CXCL6,CXCR4,FANCG,GADD45A,GADD45G,IL12B,ODC1,PTGS2,TNFSF8 | NA |
| UM101 | NA | chemical drug | NA | 3.30e-01 | 0.0e+00 | CCL17,CXCL10,EXOC3L4,GBP4,HAS3,IL1A,MMP9,PLA1A,TNFSF8 | NA |
| MARK2 | 2.10e-01 | kinase | NA | 3.30e-01 | 0.0e+00 | CXCL2,CXCL3,HDC,IL12B,LMO4,LTA,PTGS2,RILPL1,RSAD2 | 452 (18) |
| tetrabromobisphenol A | NA | chemical toxicant | NA | 3.30e-01 | 0.0e+00 | BMP7,CCL2,LOX,MYC,PDGFB,SERPINH1,THBS1,TIMP1,TIMP3 | 451 (22) |
| thymoquinone | NA | chemical drug | NA | 3.30e-01 | 0.0e+00 | AR,BCL2L1,BMP2,CD14,CDKN1A,CXCR4,HMOX1,MMP9,SAT1,TNFSF10 | 502 (16) |
| MUC1 | NA | other | NA | 3.30e-01 | 0.0e+00 | BCL2L1,CD83,FASN,GCLC,ISG15,Mx2,MYC,NFKBIA,NRP1,RASSF1,STAT1,TXNRD1,UPP1 | 526 (16) |
| 8-bromo-cAMP | NA | chemical reagent | NA | 3.30e-01 | 0.0e+00 | ABL1,AOC1,ARG2,ARNT2,BCL2L1,BMP2,BMP7,Ccl2,CCNA1,CDKN1A,CLDN11,CREB1,CREM,CSF3R,DIO2,DUSP1,EDN1,ENC1,ERBB3,FOS,FOSL1,GLI1,GLUL,GNAI2,Gsta1,HYAL3,ID4,IL24,IL4R,INHBA,ITGA7,KDR,LIF,LIMK1,LOX,MAOA,MAOB,MMP9,MYC,MYLK3,Nes,NFIL3,NFKBIA,NFYA,NRP1,ODC1,OGT,P4HA1,P4HA2,PCK1,PDE4A,PDGFB,PDGFD,PLAT,PPL,PTGER3,PTGS2,RASGRF1,RPS6KA6,SAT1,SERPINE1,SHC2,STAT1,TGFBR3,THBS1,TIMP1,WNT11,WNT5A,ZBTB16 | 611 (21) |
| prostaglandin D2 | NA | chemical - endogenous mammalian | NA | 3.30e-01 | 0.0e+00 | CD40LG,CXCL10,GFI1,HAS1,HAS3,HMOX1,IL1A,MUC5B,NRP1,PLAUR,PTGS2,SDC4,TNFRSF12A | 390 (16) |
| CTSK | 5.70e-01 | peptidase | NA | 3.30e-01 | 0.0e+00 | CCL2,Ccl2,CDKN1A,CTSV,PTGS2 | 397 (21) |
| GAB2 | 6.50e-01 | other | NA | 3.30e-01 | 0.0e+00 | BCL2L1,Ccl2,CCL4,CD69,FOS,ITGA2B,KDR,MUC5B,S100A8,SERPINE1 | 468 (20) |
| MKNK1 | 1.00e-01 | kinase | NA | 3.20e-01 | 0.0e+00 | ARVCF,FOS,HSPA4L,IFRD1,ISG15,KIF21B,LCN2,MGP,MMP9,MYC,NCDN,NELL2,PDK4,RUFY4,SERPINH1,SGIP1,SLITRK6,TBC1D30,TXNIP,XDH | NA |
| NR0B1 | NA | ligand-dependent nuclear receptor | NA | 3.20e-01 | 1.0e-02 | AR,FASN,HSPA4L,LOXL1,NR5A2,PCK1,Sry | 464 (17) |
| rotenone | NA | chemical toxicant | NA | 3.20e-01 | 0.0e+00 | AR,ATF4,CXCL2,FOS,GADD45G,HMOX1,KDR,MMP9,PDGFB,PTGS2,SELL,SESN2,Sry,TIMP1,Tnfsf9,TXNIP | 530 (22) |
| JUN | 4.20e-01 | transcription regulator | NA | 3.20e-01 | 0.0e+00 | ABCB1,ANKRD1,AR,ATF3,BCL2A1,C3AR1,CCL2,Ccl2,CD14,CD274,CDKN1A,CXCL10,CXCL3,DIO2,DUSP1,EDN1,EREG,F3,FOS,FOSL1,FOXC1,GADD45A,GCLC,GNRH1,HK2,HMOX1,IL12B,IL1A,IL24,ITGAD,JUNB,KDR,LGALS3,LIF,LPAR1,LPIN1,MAOB,MMP8,MMP9,MYC,NFKBIA,NR0B2,NR5A2,NUPR1,PLAUR,Pmaip1,PTGS2,PTPRN,PTPRO,PTX3,RASGRF1,RGN,SERPINE1,SLC38A2,SLC6A6,SLC7A1,SOCS3,SOX2,SPHK1,Spry1,STAT1,THBS1,TIMP1,TIMP3,TP73,WNT5A,ZEB2,ZFP36 | 596 (21) |
| Gm21596/Hmgb1 | NA | transcription regulator | NA | 3.20e-01 | 1.0e-02 | CDKN1A,CXCL3,CXCL6,CXCR4,IL24 | NA |
| ATP2A2 | -2.40e-01 | transporter | NA | 3.10e-01 | 0.0e+00 | ADGRE1,ATP2B3,ATP2B4,Ccl2,FASN,Pln,SYT1 | 220 (8) |
| chloroquine | NA | chemical drug | NA | 3.10e-01 | 0.0e+00 | ADAMTS5,AGR2,ATP1A1,BCL2L1,CD69,CD83,CXCL10,IL12B,IRS1,MAP1LC3B,SELE,SOCS3,SOX2,TNFSF10 | 476 (19) |
| HMOX1 | 6.40e-01 | enzyme | NA | 3.10e-01 | 0.0e+00 | ADORA2A,ANGPTL3,AQP1,BCL2L1,CCL17,CCL2,Ccl2,CD14,CD274,CDKN1A,CXCL10,CXCL2,CXCL3,FOS,GCLC,HMOX1,IL12B,KDR,MAP1LC3B,MMP9,PROCR,PTGS2,SELE,THBS1,ZFP36 | 456 (13) |
| USF2 | 8.00e-02 | transcription regulator | NA | 2.90e-01 | 0.0e+00 | CPT1A,CPT1B,FASN,HMOX1,MYC,P4HA1,SERPINE1,SPEG,TBX21,THBS1,XCL1 | 211 (7) |
| trans-hydroxytamoxifen | NA | chemical drug | NA | 2.90e-01 | 0.0e+00 | ANXA3,ARNT2,BRPF1,CTSH,DDIT4,DUSP1,EGR3,ENC1,ERBB3,GCLC,IER3,KRT7,KRT81,KYNU,LOX,MMD,NELL2,PPP1R3C,PTGER3,RND3,SELENBP1,STAT1 | 435 (10) |
| miR-142-3p (and other miRNAs w/seed GUAGUGU) | NA | mature microRNA | NA | 2.80e-01 | 4.0e-02 | BCL2L1,F9,IL12B,PPP3R1 | NA |
| etanercept | NA | biologic drug | NA | 2.80e-01 | 0.0e+00 | BMP7,CCL2,CD274,CD83,CXCL10,GZMB,IL12B,PTGS2,SLC10A1,Slco1a1,STAT1 | 450 (14) |
| panobinostat | NA | chemical drug | NA | 2.80e-01 | 0.0e+00 | BCL2L1,CDKN1A,CEBPD,CXCL10,MYC,MYCN,NGFR,PPP1R1B,PTGS2,SERPINE1,TP73 | 412 (18) |
| PRKAA1 | -1.80e-01 | kinase | NA | 2.80e-01 | 0.0e+00 | ALB,ATF3,CD163,CDKN1A,ERN1,FKBP5,GJB2,IFI44,IL12B,IL22RA1,KCNA2,LMO4,MMP16,MMP9,NFKBIA,OPHN1,PTPRN,RND3,SOCS3,TXNIP | 485 (22) |
| GPX1 | 6.00e-02 | enzyme | NA | 2.80e-01 | 0.0e+00 | ADGRE1,Ccl2,CCL4,CD14,CXCL10,CXCL3,MMP9,TNFSF10 | 414 (15) |
| BAP1 | 2.90e-01 | peptidase | NA | 2.80e-01 | 1.0e-02 | ATF3,ATF4,Ccl2,CXCL2,LIF | 311 (7) |
| erismodegib | NA | chemical drug | NA | 2.80e-01 | 2.0e-02 | BCL2L1,CCL2,IL1A,MMP9,PTGER3 | NA |
| PIK3C3 | 8.00e-02 | kinase | NA | 2.80e-01 | 2.0e-02 | CIDEA,DIO2,FASN,PNPLA2,PPARA | NA |
| GIP | NA | other | NA | 2.80e-01 | 0.0e+00 | ATF3,CCL2,Ccl2,CCL4,CXCL10,CXCL2,CXCL3,FOS,GBP2,GBP5,IL12B,IL1A,IL4R,PCK1,RSAD2,SERPINE1,SOCS3 | 328 (16) |
| Hsp27 | NA | group | NA | 2.70e-01 | 0.0e+00 | CD14,CD163,CD274,CD40LG,CDKN1A,FOS,IL6R,NGFR,PPP1R1B,PTGS2,TRIM63 | 463 (17) |
| sanglifehrin A | NA | chemical reagent | NA | 2.70e-01 | 0.0e+00 | CCL17,CCL19,CDKN1A,CXCL10,IL12B | 247 (9) |
| SUB1 | 7.00e-02 | transcription regulator | NA | 2.60e-01 | 0.0e+00 | FJX1,FOS,GADD45A,KCNA6,KCNG1,KCNJ4,KCNK2 | NA |
| PIK3CA | -2.50e-01 | kinase | NA | 2.60e-01 | 0.0e+00 | ADAMTS1,ADAMTS5,ARG2,ATP1A1,BMP6,Ccl2,CD14,CEBPD,CXCL6,CXCR4,EZH2,F2RL1,F3,FASN,GALNT3,HMOX1,IL33,IRS1,KDR,LIF,LOX,LTA,MYC,NFKBIA,NGFR,PDGFB,PROCR,PTGS2,PTX3,RUNX1T1,SERPINE1,TGM1,TNFSF10 | 486 (18) |
| KAT5 | 4.50e-01 | transcription regulator | NA | 2.60e-01 | 2.0e-02 | ADAMTS1,ALB,CDKN1A,COL2A1,CRELD2,CXCR4,EREG,FOXC1,GADD45A,GADD45B,HNF4A,IRS1,MYC,NGFR,OTUB2,PCDH20,PCDHB2,WNT7A | NA |
| IL15 | -9.00e-02 | cytokine | NA | 2.60e-01 | 0.0e+00 | AQP3,ATF4,BCL2L1,CBLB,CCL17,CCL19,CCL2,Ccl2,CCL4,CCR9,CD274,CD28,CD40LG,CD69,CD83,CD84,CD8A,CDKN1A,CHRNA7,CPT1A,CTSW,CX3CR1,CXCL10,CXCL2,CXCL3,CXCR4,DPYSL5,EDN1,ELK3,ENO3,FMO3,GZMB,HK2,HMCN1,HMOX1,ICAM5,ID4,IFIT1,IL12B,IL1A,IL21R,IL24,IL2RB,ISG15,ITGB7,JUNB,KLRD1,Klrk1,LCK,LIF,LTA,MAPKAPK3,MX1,MYC,NFIL3,NFKBIA,PFKFB3,PPARGC1B,PRF1,PTPRC,RGS16,SELL,SERPINE1,SLC16A3,SOCS2,SPN,TBX21,TIMP1,TNFRSF13C,TNFRSF18,TNFSF10,TXNRD1,UPP1,ZFP36 | 441 (18) |
| dihydrotestosterone | NA | chemical - endogenous mammalian | NA | 2.60e-01 | 0.0e+00 | ADAMTS1,ADH1C,AQP1,AR,AZGP1,BCL2L1,BMP7,BTG2,CCNA1,CCNO,CDCA7,CDKN1A,CDO1,CPT1A,DIO2,DYNLL1,EZH2,FASN,FKBP5,FOS,FTL,G0S2,GJB2,GLUL,GNRH1,HK2,HSD11B2,IL12B,IL1A,IL6R,IRS1,KLF15,LAMA5,LOX,MAFF,MAOA,MAP2K6,MCAM,MMP9,Mt1,MYC,MYRIP,NEDD4L,NFKBIA,ODC1,PCK1,PER1,PPARA,PPP1R1B,PRUNE2,PTGS2,RGN,SEC14L2,SELENBP1,SFTPB,SLC2A5,SLC7A6,SLC7A7,Slco1a1,ST6GALNAC5,STBD1,TGFBR3,THBS1,TIMP3,TNFSF10,WNT5A,WNT7A,ZBTB16 | 596 (22) |
| bile acid | NA | chemical - endogenous mammalian | NA | 2.60e-01 | 0.0e+00 | ABCB11,BCL2L1,DIO2,FMO3,HDC,HNF4A,NR0B2,PTGS2,SLC10A1 | 391 (22) |
| HA900 | NA | chemical reagent | NA | 2.50e-01 | 0.0e+00 | CCL2,CXCL3,SELP,SOCS3 | NA |
| SFTPD | 4.70e-01 | other | NA | 2.50e-01 | 0.0e+00 | CCL2,Ccl2,CD14,CXCL2,CXCL3,MMP9 | 291 (16) |
| cyclic GMP | NA | chemical - endogenous mammalian | NA | 2.50e-01 | 1.0e-02 | CDKN1A,FOS,RYR2,SERPINE1 | 447 (19) |
| glyburide | NA | chemical drug | NA | 2.50e-01 | 1.0e-02 | CCL2,FOS,HMOX1,IL12B | 451 (21) |
| irinotecan | NA | chemical drug | NA | 2.50e-01 | 1.0e-02 | BCL2L1,CXCL10,F3,MMP9,SOCS3 | NA |
| 3-aminobenzamide | NA | chemical toxicant | NA | 2.50e-01 | 3.0e-02 | CDKN1A,IL12B,MMP9,TIMP1 | NA |
| ADORA2B | 9.20e-01 | G-protein coupled receptor | NA | 2.50e-01 | 0.0e+00 | CCL17,Ccl2,CCNA1,CXCL2,CXCL3,HSD11B2,MMP9,SERPINE1,SOX2,TIMP1 | 464 (19) |
| Ras homolog | NA | group | NA | 2.50e-01 | 0.0e+00 | CDKN1A,FOS,MMP9,MYC,PTGS2 | 432 (19) |
| SOCS3 | 1.12e+00 | phosphatase | NA | 2.40e-01 | 0.0e+00 | APOB,ATF3,Ccl2,CDKN1A,CXCL10,F3,FASN,FOS,IFIT1,IL12B,IL4R,IRS1,MX1,Mx2,OAS2,PCK1,PLAUR,SELP,SOCS3,TBX21 | 535 (17) |
| ITGB1 | 1.60e-01 | transmembrane receptor | NA | 2.40e-01 | 0.0e+00 | ADAMTS5,CCL2,Ccl2,CCL4,CD14,CDKN1A,CXCL10,FOS,GBP2,HAS1,HAS3,IL12B,ITGA7,ITGB7,JUNB,LOX,LOXL1,MMP9,MYC,PLAUR,PTGS2,SEMA5B,SERPINE1,SIDT1,THBS1,WNT5A | 427 (19) |
| ID3 | -3.60e-01 | transcription regulator | NA | 2.40e-01 | 0.0e+00 | BCL2L1,BLK,BMP7,BTG2,CCR10,CCR9,CD40LG,CD79A,CD83,CDKN1A,CXCR4,DUSP1,GADD45B,GADD45G,IKZF3,IL2RB,IL4R,IL6R,IRF4,LMO4,LTA,LTB,MAP2K6,MMP9,MYC,PIK3C2B,PIK3IP1,RAPGEF4,SELE,SELL,SEMA7A,SLAMF6,SOCS3,TGFBR3,TNFSF10,TNFSF8,ZBTB16 | 423 (15) |
| ABT-737 | NA | chemical drug | NA | 2.40e-01 | 0.0e+00 | BCL2A1,BCL2L1,CDKN1A,CXCL3,GADD45A | 452 (17) |
| CARD9 | -6.00e-02 | other | NA | 2.40e-01 | 1.0e-02 | Ccl2,CXCL10,CXCL2,CXCL3,IL12B,IL1A | 362 (16) |
| RPSA | 2.60e-01 | translation regulator | NA | 2.40e-01 | 0.0e+00 | CXCL3,DUSP1,GBP4,IL1A,ISG15,PTGS2,STAT1 | 405 (15) |
| TWIST2 | 1.40e-01 | transcription regulator | NA | 2.40e-01 | 2.0e-02 | BCL11A,CDKN1A,MMP9,MYCN,OSGIN1,SOX2,ZEB2 | NA |
| cholic acid | NA | chemical - endogenous mammalian | NA | 2.40e-01 | 0.0e+00 | ABCB1,ABCB11,ABCC2,CIRBP,Cyp4a14,CYP7B1,NR0B2,PCK1,PON1,SLC10A1,Slco1a1,TRH,VIPR2 | 268 (12) |
| TLR9 | -3.40e-01 | transmembrane receptor | NA | 2.30e-01 | 0.0e+00 | ADAMTS4,ARG2,ATF3,BCL2L1,CCL17,Ccl2,CCL4,CD27,CD274,CD69,CD83,CERS6,CXCL10,CXCL2,CXCL3,CXCL6,DUSP1,EDN1,FCER2,FCMR,GADD45B,HMOX1,IER3,IFI44L,IFIT1,IL12B,IL1A,IL21R,IL33,IRF4,ISG15,LCN2,LTA,MX1,MYC,NR0B2,OAS2,Oasl2,PFKFB3,PROCR,PTGS2,RSAD2,S100A8,SERPINE1,SOCS3,SPHK1,STAT1,TBX21,TIMP1,TNFSF10,USP18 | 524 (16) |
| GLI3 | 4.00e-02 | transcription regulator | NA | 2.30e-01 | 2.0e-02 | CD69,DLL1,DUSP1,GLI1,GNRH1,JUNB,MYCN,OSR1,PAX5,TBX6,WNT5A | NA |
| STAT5A | -3.40e-01 | transcription regulator | NA | 2.30e-01 | 0.0e+00 | ABCB1,AGR2,AR,BCL11A,BCL2A1,BCL2L1,Ccl2,CDKN1A,CEMIP,EZH2,FASN,FGFBP1,FOS,FOSL2,GADD45A,GADD45G,GJB1,GZMA,GZMM,IFITM2,IL24,IL2RB,IL6R,Klrc2/Klrc3,Klre1,Klrk1,KRT80,LCN2,LTA,LTB,MUC13,MYC,PRF1,RNF39,S1PR5,SELENBP1,SETBP1,SLC10A1,SLC2A10,SLC7A7,SNTB1,SOCS2,SOCS3,SYTL2,TBX21,TNFRSF14,TNFRSF18,TXNIP,ZFP36 | 568 (20) |
| GATA3 | -1.40e-01 | transcription regulator | NA | 2.30e-01 | 0.0e+00 | BCL11A,BCL11B,BCL2L1,CCL4,CCR3,CDKN1A,CXCR4,Elf5,FOS,GLUL,GZMA,IL24,IL2RB,KRT17,LOX,LTA,LTB,MYC,NFIL3,NR5A2,PAX5,PPARA,PPL,RGCC,S100A8,TBX21,TGM1,WNT11,ZBTB16,ZEB2 | 481 (22) |
| mir-8 | NA | microRNA | NA | 2.30e-01 | 1.0e-02 | ADAMTS1,ATF3,BMP2,CDKN1A,CPT1A,ERRFI1,EZH2,FAT2,HMOX1,KCNK1,KDR,LOX,MYC,Pmaip1,PPARA,SOX2,ZEB2,ZFP36,ZFPM2 | NA |
| ammonium | NA | chemical - endogenous mammalian | NA | 2.30e-01 | 1.0e-02 | ABCB1,ANGPTL3,ATP1A1,DYNLL1,DYSF,EPHA2,G0S2,GALNT15,KLF15,MYBPH,NPC2,PKIA,RCN1,RGS16,SESN2,SLC38A2,STBD1,TTC30B,ZEB2 | NA |
| SATB1 | -4.60e-01 | transcription regulator | NA | 2.30e-01 | 0.0e+00 | BCL2A1,BTLA,CD69,CD8A,CDKN1A,CSF3R,GADD45B,GATA5,HLA-DOB,IL1R2,IL4R,LAG3,LAX1,LPIN2,LRRN3,Meis1,PIK3IP1,PRKCB,PTGS2,SELL,TBX6,TGFA,TNFRSF8 | 262 (7) |
| HAVCR1 | NA | other | NA | 2.20e-01 | 0.0e+00 | CEMIP,EREG,HK2,IL1R2,IL6R,LMO4,NFKBIA,ODC1,PFKFB3,PLAUR,SESN2,SLC16A4,SMARCA1,SOCS3,STAT1,TBX21 | 352 (11) |
| [D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin | NA | chemical reagent | NA | 2.20e-01 | 0.0e+00 | CCL2,CXCL10,FOS,OPN4 | 448 (23) |
| mibolerone | NA | chemical drug | NA | 2.20e-01 | 4.0e-02 | AR,BMP6,CCDC116,F3,FASN,FKBP5,FOSL2,GADD45G,MYC,PRKCH,SPOCK1,TIMP3,USP18 | NA |
| propylthiouracil | NA | chemical drug | NA | 2.20e-01 | 0.0e+00 | BCL11A,BCL11B,BTG2,CD69,Clec2e/Clec2h,CRYM,CXCL2,DIO1,DIO2,DLK1,FMO3,GBP4,GHRHR,GLUL,MOXD1,MPP3,MYOCD,NRN1,NRP1,RBFOX1,SERPINB1,SERTAD4,SLC13A3,SLC22A7,SLC2A5,TRH,TXNIP | 165 (5) |
| 4,4’-diisothiocyanostilbene-2,2’-disulfonic acid | NA | chemical drug | NA | 2.20e-01 | 0.0e+00 | Ccl2,CHRNA7,IL12B,MMP9 | 335 (19) |
| PPP3CA | -2.30e-01 | phosphatase | NA | 2.20e-01 | 0.0e+00 | CD40LG,CDKN1A,CPT1A,CTSV,CXCL2,FTL,Gsta1,LPAR1,MAOB,POU2AF1,PPP3R1,PTGS2,SDC4 | 466 (23) |
| quizartinib | NA | chemical drug | NA | 2.20e-01 | 0.0e+00 | CBS/LOC102724560,DDIT4,FGF11,GADD45G | NA |
| GPRC6A | NA | G-protein coupled receptor | NA | 2.20e-01 | 1.0e-02 | ADGRE1,CIDEA,DIO2,PNPLA2 | NA |
| PCBP2 | 1.00e-01 | other | NA | 2.20e-01 | 2.0e-02 | CDKN1A,CSF3R,MYC,STAT1 | NA |
| CNR2 | -7.00e-02 | G-protein coupled receptor | NA | 2.20e-01 | 2.0e-02 | CCL2,Ccl2,CXCL10,GRK5,PTGS2 | NA |
| BMPR2 | -2.90e-01 | kinase | NA | 2.20e-01 | 2.0e-02 | CD274,EPHA4,INHBA,PTX3,SELE | NA |
| BMP7 | -7.90e-01 | growth factor | NA | 2.20e-01 | 0.0e+00 | ADGRL2,ADORA1,ADORA2A,BMP2,BMP7,CCL2,CDKN1A,CEBPD,CIDEA,CXCR4,CXXC5,DLK1,DUSP1,EDN1,ERBB3,EREG,F3,FASN,GLUL,GRB14,HPCAL1,HSD11B2,IRS1,LOXL1,MAOA,Meis1,MMP9,NGFR,PKIA,PPARGC1B,SERPINE1,SOCS3,SOSTDC1,TIMP1,WNT11,WNT5A,ZEB2 | 420 (19) |
| TNFSF14 | 6.00e-02 | cytokine | NA | 2.20e-01 | 0.0e+00 | ADORA2B,BCL2L1,CCL19,Ccl2,CXCL10,CXCL3,F2RL1,INHBA,MMP9 | 408 (17) |
| bisphenol A | NA | chemical - endogenous mammalian | NA | 2.20e-01 | 0.0e+00 | APOB,AR,ARNT2,CCL2,CDKN1A,CTSV,CXCL10,EREG,FOS,HMOX1,ICAM5,KDR,KLHL41,LCN2,MAOA,MMP9,PER1,PTGS2,SLC6A13,Slco1a1,SLFN12,SOX2,STK17B,THBS1,TIMP3,TRA2A,WNK2 | 562 (24) |
| n-3 fatty acids | NA | chemical drug | NA | 2.20e-01 | 0.0e+00 | CBS/LOC102724560,CCL2,FASN,HMOX1,IRS1,PDGFB,PEMT,PPARA,PTGS2,RGN | 452 (19) |
| NFkB (family) | NA | group | NA | 2.20e-01 | 0.0e+00 | BCL2L1,CCL2,CCL4,CXCL10,HNF4A,IL33,LTA,MMP9,PLAT,PTGS2,S100A8,SELE,TIMP1,TNFSF10 | 401 (17) |
| TNC | 0.00e+00 | other | NA | 2.10e-01 | 0.0e+00 | ADAMTS4,CCL2,Ccl2,CCL4,CD8A,CDKN1A,COL2A1,CXCL3,CXCL6,EDNRA,EREG,FOS,IL1A,MYC | 334 (14) |
| carbon monoxide | NA | chemical - endogenous mammalian | NA | 2.10e-01 | 0.0e+00 | ADORA2A,ATF4,CCL2,CCL4,CD14,CDKN1A,F3,HMOX1,IL12B,PLAUR,PTGS2,SELP,SERPINE1 | 528 (21) |
| aprepitant | NA | chemical drug | NA | 2.10e-01 | 0.0e+00 | CCL28,FLRT3,INHBA,S100A8,SEMA7A,SLC6A2,SPON2,TIMP3,XDH | NA |
| PIAS1 | -2.40e-01 | transcription regulator | NA | 2.10e-01 | 0.0e+00 | ABCB11,CCL2,CDKN1A,DLGAP1,DOC2A,FASN,GADD45A,GRIK4,MYC,NR0B2,PRKCG,STAT1 | 549 (22) |
| KL | 1.20e-01 | enzyme | NA | 2.10e-01 | 0.0e+00 | ATF3,ATF4,BCL2L1,Ccl2,CDKN1A,CYP46A1,KDR,MERTK,MMP9,MYC,SELP | 422 (17) |
| Map3k7 | NA | kinase | NA | 2.10e-01 | 0.0e+00 | AR,BCL2L1,BHLHE40,Ccl2,CCL4,CMPK2,CXCL10,CXCL2,CXCL3,EDN1,FASN,ID4,ISG15,MMP9,Mx2,NFKBIA,OSR1,PTGS2,RILPL1,RSAD2,RUNX1T1,SESN1,SPHK1,WNT11 | 257 (12) |
| HDAC2 | -1.90e-01 | transcription regulator | NA | 2.10e-01 | 0.0e+00 | CD27,CDKN1A,COL2A1,EPGN,EZH2,F3,FAM107A,FCER2,GABARAPL1,GLI1,IL12B,IL1A,ITGAD,MMP16,MMP9,MYC,MYCN,NFKBIA,PDGFB,PTGS2,SYCE1,THEMIS,TNFRSF19,TNFSF10 | 376 (24) |
| CCN2 | NA | growth factor | NA | 2.00e-01 | 0.0e+00 | Acan,ADAMTS1,ADAMTS4,ADAMTS5,BCL2A1,BCL2L1,COL2A1,LOX,LOXL1,MMP9,MYC,P4HA1,PDGFB,SDC4,SERPINE1,SOX2,TIMP1,TIMP3 | 520 (19) |
| KLF11 | 3.80e-01 | transcription regulator | NA | 2.00e-01 | 0.0e+00 | ADAMTS1,BMP7,CCL2,Chrm2,CPT1B,CXCR4,DIO2,EDN1,FABP3,IL12B,LOX,MAOB,MMP8,MMP9,MYC,PCK1,PDGFB,PDK4,PLAT,PLG,SERPINE1,SERPINH1,STAT1,THBS1,TIMP1,TIMP3 | 368 (12) |
| SORL1 | NA | transporter | NA | 2.00e-01 | 0.0e+00 | ADCYAP1R1,AQP1,AZGP1,BMP2,COL2A1,CTHRC1,EDN3,EDNRA,EPHA4,F10,F3,FOS,GAL,INHBA,KCNJ4,LYVE1,NGFR,PGF,PLXND1,ROR2,SDC4,TGFBR3,VIPR2,WNT5A,WNT7A | NA |
| Collagen(s) | NA | complex | NA | 2.00e-01 | 0.0e+00 | ATF4,C3AR1,CR2,EDEM1,GZMA,PRF1,PSAT1,SELP,SERPINH1,THBS1 | NA |
| GPR39 | 5.00e-02 | G-protein coupled receptor | NA | 2.00e-01 | 0.0e+00 | CCL2,EDN1,F3,GLI1,INHBA,PGF,PNPLA2,RGS16,SERPINE1 | 347 (15) |
| ionomycin | NA | chemical reagent | NA | 2.00e-01 | 0.0e+00 | BCL2A1,BCL2L1,BMP2,CCL2,CCR6,CD40LG,CD69,CLDN4,CXCL10,DUSP1,FCER2,FOS,GBP4,GEM,GZMB,HK2,IL12B,IL24,IRF4,LTA,MMP9,MYC,NFIL3,NRP1,PAX5,POU2AF1,PRF1,PTGS2,Sik1,SLC6A6,SOCS2,TBX21,TNFRSF18,TNFSF10,Tnfsf9,XCL1,ZBTB16 | 413 (16) |
| MTF1 | 1.00e-02 | transcription regulator | NA | 2.00e-01 | 0.0e+00 | ADAMTS5,MMP9,Mt1,PGF | NA |
| IRAK3 | 2.00e-02 | kinase | NA | 1.90e-01 | 0.0e+00 | BCL2A1,Ccl2,CD274,CXCL2,CXCL3,IL12B,NFKBIA | 287 (15) |
| CD70 | NA | cytokine | NA | 1.90e-01 | 0.0e+00 | BCL2A1,CD27,CD69,CR2,CXCL10,Klrk1,SELL | 475 (21) |
| POLDIP2 | NA | other | NA | 1.90e-01 | 0.0e+00 | CCL2,GFPT2,HK2,LGALS3,MYOCD,OGT | NA |
| dipyridamole | NA | chemical drug | NA | 1.90e-01 | 0.0e+00 | BCL2L1,CCL2,HMOX1,MMP9,PTGS2,RASSF1,TIMP1 | 261 (13) |
| IL-35 | NA | complex | NA | 1.90e-01 | 0.0e+00 | CCL24,CXCL2,CXCL6,SOCS3,TIMP1,XCL1 | 355 (16) |
| niacinamide | NA | chemical - endogenous mammalian | NA | 1.80e-01 | 2.0e-02 | BCL2A1,CCL2,CD14,CDKN1A,FASN,JUNB,MMP9,MYC,NFYA,PDK4,PTGS2 | NA |
| PLA2G4A | -2.60e-01 | enzyme | NA | 1.80e-01 | 2.0e-02 | CCL2,Ccl2,MYC,PTGS2 | NA |
| E. coli lipopolysaccharide | NA | chemical - endogenous non-mammalian | NA | 1.80e-01 | 0.0e+00 | BCL2L1,CCL2,Ccl2,CCL4,CD83,CEBPD,CXCL10,CXCL2,CXCL3,CXCL6,IL12B,IL1R2,MMP9,MX1,PTGS2,S100A8,SELE,SOCS3,TREM3 | 344 (14) |
| HHEX | 3.00e-02 | transcription regulator | NA | 1.80e-01 | 0.0e+00 | ANKRD1,CCL28,CXCL10,IL33,KDR,NRP1,SLC10A1,TNFSF10,TNFSF8 | NA |
| FHL2 | 4.00e-01 | transcription regulator | NA | 1.70e-01 | 2.0e-02 | ADGRE1,Ccl2,CLDN5,CLEC10A,CXCL10,IL12B,WNT5A | NA |
| AIRE | NA | transcription regulator | NA | 1.70e-01 | 3.0e-02 | BMP2,CCL17,CCL19,CD274,CXCL10,CXCL2,CXCL3,ICA1,IFI44,MMP9,TNFSF10,UPP1 | NA |
| IL25 | -3.00e-01 | cytokine | NA | 1.70e-01 | 0.0e+00 | BTG2,CCL17,CCL2,Ccl2,CCL24,CIDEA,CLDN5,GFI1,IL12B,IL1R2,IL33,KDR,Mt1,TNFRSF8 | 525 (20) |
| CEBPA | 1.30e-01 | transcription regulator | NA | 1.70e-01 | 0.0e+00 | ABCB1,ADH1C,ALB,APCDD1,APOB,ARG2,ATF4,BCL2A1,BTG2,C3AR1,CCL4,CD14,CD19,CD3G,CDKN1A,CEBPD,CIITA,CPB2,CPT1A,CSF3R,CXCR4,Elf5,F9,FASN,FOS,G0S2,GADD45A,GAL,GLI1,Gsta1,GTF3A,HMOX1,IER3,IKZF3,IL12B,IL6R,IRS1,ISG15,JUNB,KCNMB1,KRT17,KRT7,LCK,LCN2,MMP8,MYC,MYCN,NFIL3,NR5A2,NRP1,OAS2,PAX5,PCK1,PLXND1,PPARA,PPL,PPP1R3C,PTGS2,PTPRC,PTX3,S100A8,SERPINB1,SERPINE1,SFTPB,SLC10A1,SOCS3,SPNS2,TFR2,THBS1,THRB,TNFAIP6,TNFRSF19,TNFSF10,TRIB1 | 465 (19) |
| GTF2I | -2.60e-01 | transcription regulator | NA | 1.70e-01 | 0.0e+00 | CDKN1A,FOS,KDR,MYC,THBS1 | 410 (13) |
| 10E,12Z-octadecadienoic acid | NA | chemical - endogenous mammalian | NA | 1.60e-01 | 0.0e+00 | ARHGEF15,ATF3,ATF4,CCL2,Ccl2,CPT1A,CPT1B,ENDOU,FASN,LGALS12,LPIN1,PBK,PNPLA2,PTGS2,RASGRF1,SCN4A,SLC38A3,SNCAIP,SOX7 | 493 (21) |
| USP18 | -6.20e-01 | peptidase | NA | 1.60e-01 | 1.0e-02 | Ccl2,CXCL10,ISG15,MX1,SOCS3,TNFSF10 | 290 (17) |
| halofuginone | NA | chemical drug | NA | 1.60e-01 | 0.0e+00 | AOC1,BHLHE40,CTHRC1,CXCL10,EHD3,IFITM2,IL33,ITGA7,LIN7A,LOX,MMP9,POR,RGCC,SCN1B,SLC13A3,Sry,TIMP1,Tsc22d3,WNT5A | 342 (12) |
| MXD1 | 1.30e-01 | transcription regulator | NA | 1.60e-01 | 3.0e-02 | BTLA,CIITA,EDN1,GCSAM,NEDD9,ODC1,OXA1L,TNFRSF21,XCR1 | NA |
| 2-aminopurine | NA | chemical reagent | NA | 1.60e-01 | 1.0e-02 | CXCL10,HMOX1,IFIT1,ISG15,PTGS2 | 458 (18) |
| 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine | NA | chemical - endogenous non-mammalian | NA | 1.50e-01 | 0.0e+00 | CD40LG,GZMA,GZMB,PRF1 | NA |
| PEBP4 | -4.00e-02 | other | NA | 1.50e-01 | 0.0e+00 | BCL2L1,CDKN1A,NFKBIA,PTGS2 | 336 (10) |
| perilla alcohol | NA | chemical drug | NA | 1.50e-01 | 0.0e+00 | BCL2A1,CDKN1A,NFKBIA,SELP | 350 (13) |
| SH3KBP1 | -1.90e-01 | other | NA | 1.50e-01 | 0.0e+00 | BCL2A1,BCL2L1,MYC,SERPINE1 | 419 (19) |
| lipofermata | NA | chemical reagent | NA | 1.50e-01 | 0.0e+00 | ACOX2,ATF3,ATF4,CPT1A,PDGFB,PPARA | NA |
| IL23A | 2.40e-01 | cytokine | NA | 1.50e-01 | 1.0e-02 | Ccl2,CXCL10,HPX,S100A8,STAT1,TBX21,XCL1 | 430 (20) |
| CRTC1 | -2.30e-01 | transcription regulator | NA | 1.50e-01 | 1.0e-02 | NEDD9,PDE10A,PER1,PTGS2,TIMP1 | 347 (11) |
| GSTO1 | 2.10e-01 | enzyme | NA | 1.50e-01 | 2.0e-02 | F3,IFIT1,LAMA5,SAT1,SRGAP1,STAT1,TGFA,THBS1 | NA |
| miR-293-5p (and other miRNAs w/seed CUCAAAC) | NA | mature microRNA | NA | 1.50e-01 | 2.0e-02 | ADORA1,AKAP6,KLF15,MMP9 | NA |
| PYCARD | -2.10e-01 | transcription regulator | NA | 1.50e-01 | 3.0e-02 | CDKN1A,IL22RA2,MMP9,PTGS2,S100A8 | NA |
| WT1 | 3.60e-01 | transcription regulator | NA | 1.50e-01 | 0.0e+00 | ADGRE5,BCL2A1,BCL2L1,BTG2,CBS/LOC102724560,CCL2,CCL24,CDKN1A,CIRBP,CTSV,CXCL10,CXCL3,EREG,IL2RB,JUNB,LGALS3,MMP9,MYC,MYCN,ODC1,PLAUR,Podxl,SERPINE1,SLC6A6,Sry,THBS1,TIMP3,TNFSF10,TNFSF8 | 476 (23) |
| sorbitol | NA | chemical - endogenous mammalian | NA | 1.50e-01 | 1.0e-02 | AQP1,BCL2L1,CDKN1A,ERRFI1 | 432 (19) |
| gemcitabine | NA | chemical drug | NA | 1.50e-01 | 0.0e+00 | ABCB1,AQP3,BCL2L1,BTG2,Ccl2,CD274,CDKN1A,CPT1A,CXCR4,FASN,FOSL1,HMOX1,MMP9,MYC,PTGS2,SLC28A3,TGFA,TP73 | 368 (14) |
| 8-bromoguanosine 3’,5’-cyclic monophosphate | NA | chemical reagent | NA | 1.50e-01 | 0.0e+00 | BMP2,CD8A,CDKN1A,EDN1,FOS,HMOX1,JUNB,MMP9,PLAUR | 392 (15) |
| C1QA | 1.40e-01 | other | NA | 1.40e-01 | 0.0e+00 | C3AR1,Ccl2,CD163,CD274,CXCL10,F3,LCN2,MERTK,SERPINE1,TIMP1 | 490 (16) |
| YAP1 | NA | transcription regulator | NA | 1.40e-01 | 1.0e-02 | ADAMTS1,ANKRD1,AURKB,BCL2L1,BMP2,CCL2,Ccl2,CD274,CDKN1A,CPT1A,CXCL2,CXCL3,CXCR4,DNASE1L3,EDN1,ENDOU,FASN,FOS,GADD45A,IFIT1,IL12B,IL1A,INHBA,LOX,MMP16,MYC,NFKBIA,NRIP3,NUPR1,P4HA1,PDGFB,PDK4,PTGS2,SCIN,SERPINE1,SFN,SOX2,STAT1,THBS1,TIMP1,TP73,TRIM63,ZNF322 | 465 (21) |
| IL13 | NA | cytokine | NA | 1.40e-01 | 0.0e+00 | ADAMTS4,ADORA1,ADORA2A,ADORA2B,ARG2,ATF3,BCL2A1,BCL2L1,BPIFB1,C3AR1,CCL17,CCL2,Ccl2,CCL24,CCL4,CD101,CD14,CD163,CD37,CDH26,CIDEA,CLCA1,CLEC10A,CTSH,CTSV,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,CYSLTR1,F3,FCER2,G0S2,GAS7,GJB1,GNAI2,HDC,HMOX1,IL12B,IL1R2,JAKMIP2,LILRB3,MAOA,MAP2K6,MERTK,MMP9,MUC5B,PTGS2,S100A8,SELP,SERPINE1,SLC43A3,SLC7A7,SOCS3,SOX2,SPHK1,THBS1,TIMP1,TRPV1,WNT5A | 524 (17) |
| TGFBR1 | -2.20e-01 | kinase | NA | 1.40e-01 | 0.0e+00 | Acan,BHLHE40,C3AR1,Ccl2,CCL4,CDKN1A,CLDN5,CXCL10,CXCL3,EDN1,HMOX1,HNF4A,ID4,IL12B,IL22RA2,LIMK1,LTB,MYC,OSR1,PDGFB,PDK4,PRKCB,PTX3,SERPINE1,SFTPB,STAT1,WNT11,ZFP36 | 445 (19) |
| PTGES | -2.10e-01 | enzyme | NA | 1.30e-01 | 2.0e-02 | Ccl2,CDKN1A,CXCL3,ERBB3,MMP9,MYC,PTGS2,SERPINE1 | NA |
| MMP2 | 2.30e-01 | peptidase | NA | 1.30e-01 | 1.0e-02 | BCL2L1,BMP2,Ccl2,CDKN1A,CLDN5,ICAM5,IL4R,MYC,PDK4,PLG | 483 (20) |
| ALDH1A1 | -1.80e-01 | enzyme | NA | 1.30e-01 | 0.0e+00 | BMP2,CPT1B,FASN,PCK1,PPARA | 489 (16) |
| MRTFA | NA | transcription regulator | NA | 1.30e-01 | 0.0e+00 | ABLIM1,ACTC1,ANKRD1,BCL2L1,CXCL6,CXCR4,EDN1,EGR3,FABP3,FCN1,FIBIN,FOS,G0S2,GADD45A,GFI1,LCN2,LIMK1,MMP16,MMP9,MYOCD,PGLYRP1,PTGS2,RPS6KA6,S100A8,SELE,SELP,SERPINE1,STAT1,THBS1,WNT5A,YPEL1 | 449 (23) |
| SOD2 | 3.70e-01 | enzyme | NA | 1.30e-01 | 0.0e+00 | ATP1A1,BCL2L1,CDKN1A,HMOX1,MMP8,MMP9,MYC,ODC1,PRMT8,PRRX1,PTGS2,PTPRO,SERPINE1,SOX2,SPEG,TRIM14 | 380 (16) |
| NBEAL2 | 3.00e-01 | other | NA | 1.30e-01 | 0.0e+00 | CCL4,CXCL10,CXCL2,CXCL3,SELP,THBS1 | 459 (14) |
| Ciap | NA | group | NA | 1.30e-01 | 0.0e+00 | BCL2L1,Ccl2,CCL4,CXCL2,IL12B,IL1A,MYC | 410 (12) |
| HDL | NA | complex | NA | 1.30e-01 | 1.0e-02 | ATF3,CCL2,Ccl2,CD40LG,CX3CR1,PON1,PTGS2,SELP | 326 (16) |
| KDM6A | NA | enzyme | NA | 1.30e-01 | 2.0e-02 | ALB,CD274,ENO3,GAL,HNF4A,SELE,UGT2B10 | NA |
| CCL20 | -1.80e-01 | cytokine | NA | 1.30e-01 | 2.0e-02 | C3AR1,Ccl2,CX3CR1,GBP5,IL1A,ZC3H12A | NA |
| IL12B | -7.10e-01 | cytokine | NA | 1.30e-01 | 0.0e+00 | Ccl2,CEBPD,CXCL10,ERN1,GZMB,IL12B,IL1A,LTA,MAP3K8,S100A8,SOCS3,STAT1 | 366 (15) |
| NCOR1 | -4.00e-02 | transcription regulator | NA | 1.20e-01 | 0.0e+00 | ABCB11,CDKN1A,CREM,CSF3R,CXCL10,DIO1,DUSP1,FASN,ISG15,MMP9,OAS2,Oasl2,PDK4,PTGS2,TRH,ZBP1 | 376 (25) |
| CSHL1 | NA | growth factor | NA | 1.20e-01 | 1.0e-02 | AR,BMP2,FOS,GHRHR,HNF4A,SERPINH1,SOCS2,SOCS3,SSTR4 | 470 (21) |
| PML-RARA | NA | fusion gene/product | NA | 1.20e-01 | 1.0e-02 | CDKN1A,F3,FOS,GFI1,HMOX1,MYC | NA |
| acteoside | NA | chemical - endogenous non-mammalian | NA | 1.20e-01 | 2.0e-02 | FOS,GCLC,HIPK2,HMOX1,MMP9 | NA |
| FOXP1 | NA | transcription regulator | NA | 1.20e-01 | 2.0e-02 | CD274,CDKN1A,GZMB,IRF4,NR5A2,ST8SIA2 | NA |
| FOSL1 | 9.90e-01 | transcription regulator | NA | 1.10e-01 | 0.0e+00 | ANKRD1,CCL2,Ccl2,CCL4,CD274,CXCL6,EDN1,FOS,FOSL1,GCLC,JUNB,LCN2,MMP9,NRP1,PLAUR,SERPINE1,THBS1 | 447 (18) |
| ursodeoxycholic acid | NA | chemical - endogenous mammalian | NA | 1.10e-01 | 0.0e+00 | ABCB1,ABCB11,ABCC2,BCL2L1,Ccl2,CXCL10,FASN,GCLC,GLI1,IRS1,LGALS3,PTGS2,TIMP1 | 498 (24) |
| RASSF5 | -1.40e-01 | other | NA | 1.10e-01 | 2.0e-02 | CDKN1A,CIRBP,CXCL2,GTF3A,MMP9,SAT1 | NA |
| ADAMTS12 | 1.20e-01 | peptidase | NA | 1.10e-01 | 0.0e+00 | CXCL10,HDC,HPX,IL33,LCN2,MGP,S100A8,SELP | NA |
| zVAD-FMK | NA | chemical - protease inhibitor | NA | 1.10e-01 | 1.0e-02 | BCL2A1,CCL2,CD163,CDKN1A,CXCL3,FOS,MAP1LC3B,TP73 | 371 (15) |
| FOSB | 1.20e-01 | transcription regulator | NA | 1.10e-01 | 0.0e+00 | F3,FOS,FOSL1,INHBA,MMP9,SERPINE1,TIMP1 | 370 (16) |
| C3 | -2.60e-01 | peptidase | NA | 1.00e-01 | 0.0e+00 | APCS,BCL2A1,C3AR1,CCL2,Ccl2,CCL4,CR2,CRP,CXCL10,CXCL2,CXCL3,IL12B,IL1A,LCN2,PTPRC,SELL,SELP,TIMP1,ZBP1 | 466 (19) |
| cholecalciferol | NA | chemical - endogenous mammalian | NA | 1.00e-01 | 0.0e+00 | ABCB11,BCL2L1,CCL2,CD14,CD83,CEBPD,CUBN,CXCL10,DKK2,EDN1,FOS,GAS7,HK2,IL12B,NFYA,NR0B2,PDK4,PPARGC1B,PRKCB,PSAT1,SERPINE1,TNFSF10,TREML2 | 456 (22) |
| NF2 | 1.20e-01 | other | NA | 1.00e-01 | 0.0e+00 | CD274,CDKN1A,GLUL,HMOX1,IFIT1,MMP9,MYC,PLAUR | 433 (20) |
| RPTOR | 1.50e-01 | other | NA | 1.00e-01 | 1.0e-02 | ADGRE1,Ccl2,CCR9,FASN,HK2,IFI44,IL12B,IL22RA1,IRS1,MYC,PCK1,PTGS2,SIGLEC8,SOCS3,TBX21 | NA |
| sunitinib | NA | chemical drug | NA | 1.00e-01 | 0.0e+00 | CD69,CDKN1A,CXCL10,CXCL3,CXCR4,ECE1,HAS1,KDR,MMP9,PDGFB | 325 (17) |
| resveratrol | NA | chemical drug | NA | 9.00e-02 | 0.0e+00 | AR,ATF3,BCL2A1,BCL2L1,BMP2,CCL2,Ccl2,CCNA1,CD14,CD163,CD69,CDKN1A,CPT1A,CX3CR1,CXCL10,CXCL2,CXCL3,DYNLL1,ECE1,EDN1,F3,FASN,FOS,FOSL1,FOSL2,GLI1,HMOX1,IFIT1,IL12B,ISG15,ITGA2B,KDR,MMP9,MYC,NFKBIA,PCK1,PDGFB,PDK4,PON1,PPP1R13B,PTGS2,SARM1,SELP,SERPINE1,SESN2,SPHK1,TBX21,TGM1,TNFAIP6,TP73 | 421 (15) |
| DNASE2 | -1.60e-01 | enzyme | NA | 9.00e-02 | 0.0e+00 | ACKR4,CXCL10,CXCL2,ISG15,Oasl2,RSAD2,TNFSF10,USP18,ZBP1 | NA |
| TNFRSF9 | 0.00e+00 | transmembrane receptor | NA | 9.00e-02 | 1.0e-02 | BCL2A1,BCL2L1,CCR6,CD14,CD28,CD83,CIDEA,MMP9,PRF1,PTPRC | NA |
| ING1 | 2.40e-01 | transcription regulator | NA | 9.00e-02 | 1.0e-02 | CCL2,CDKN1A,ERN1,SERTAD4,TPPP,ZFP36 | NA |
| MDM2 | 4.00e-02 | transcription regulator | NA | 9.00e-02 | 0.0e+00 | ADGRE1,APOB,ATF3,Ccl2,CCNA1,CDKN1A,EZH2,HIPK2,MYCN,NR0B2,SERPINE1,SFN,THBS1,TIMP1,TNFSF10,TP73 | 467 (21) |
| ATG7 | 4.80e-01 | enzyme | NA | 9.00e-02 | 1.0e-02 | ABCB11,AGR2,ATF4,Ccl2,CMPK2,HK2,IKBKE,IRS1,MYC,NFKBIA,NR0B2,SOCS3,TET1 | 539 (18) |
| enalapril | NA | biologic drug | NA | 9.00e-02 | 0.0e+00 | ABCC2,ADAMTS1,Ccl2,CLDN4,FGA,HMOX1,IER3,KDR,LCN2,LGALS3,LOX,MYC,PTGS2,SERPINE1,TIMP1,TNFRSF12A | 475 (17) |
| chenodeoxycholic acid | NA | chemical - endogenous mammalian | NA | 9.00e-02 | 0.0e+00 | ABCB11,ABCC2,APOB,ATF4,CPT1A,FASN,FGA,GLP2R,HK2,HNF4A,IL1A,MMP9,NR0B2,NR5A2,PCK1,PDK4,PON1,PPARA,PTGS2,SLC10A1,TRPV1,TXNRD1 | 447 (23) |
| TLR7 | -4.10e-01 | transmembrane receptor | NA | 7.00e-02 | 0.0e+00 | ACAP1,ACTC1,ATF3,BANK1,BCL2A1,BMX,CCL2,Ccl2,CCL4,CD274,CD69,CD79A,CD83,CDKN1A,CXCL10,CXCL2,CXCL3,DIO2,FCMR,FOSL1,IER3,IFI44,IFI44L,IFIT1,IL12B,IL21R,ISG15,JUNB,KCNH1,LRRC34,LTA,MLPH,MX1,MYLK3,NFKBIA,OAS2,PLAT,PTX3,RSAD2,SELE,SPRED3,STAT1,TRPM2,ZC3H12A | 373 (16) |
| CCR2 | NA | G-protein coupled receptor | NA | 7.00e-02 | 0.0e+00 | CCL17,CCL2,Ccl2,CCL24,CCL4,CD163,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,IL12B,IL1A,MMP9,P4HA1,THBS1,TIMP1 | 417 (18) |
| BCR (complex) | NA | complex | NA | 7.00e-02 | 0.0e+00 | ATF3,BANK1,BCL2A1,BCL2L1,CCL4,CCR6,CD22,CD27,CD69,CDKN1A,CXCR4,FCER2,FCMR,FOS,FOSL2,GBP2,GZMB,HK2,HSH2D,IL1R2,IL24,IL2RB,IRF4,JUNB,LCK,MYC,ODC1,POU2AF1,POU2F2,PTGS2,RCL1,SELL,SLC38A2,STAT1,TBRG4,TBX21,TLR10,TNFRSF13C,TNFSF8,TRIB1,ZBP1,ZBTB16 | 495 (19) |
| NRAS | 1.40e-01 | enzyme | NA | 7.00e-02 | 0.0e+00 | AK1,ANKRD1,ANXA8/ANXA8L1,BCL2L1,CALCRL,CCL4,CDKN1A,CX3CR1,CXCL2,CXXC5,FCER2,GBP2,GLI1,IFIT1,IL1A,Irgm1,ISG15,KDR,KLRD1,LCN2,LIMK1,LY86,MGP,MYC,NPR3,PKIA,PTGS2,PTPRC,PTX3,RNASE6,SESN1,STAT1,USP18 | 396 (20) |
| STAT5a/b | NA | group | NA | 7.00e-02 | 0.0e+00 | BCL2A1,BCL2L1,BMP6,CD69,CDKN1A,DUSP1,EPHA4,FCMR,FOS,GZMB,IL1A,IL4R,ITGA2B,MMD,MYC,PAX5,PCK1,PDGFB,PRF1,PTGER3,PTGS2,SLC10A1,SOCS3,STK17B | 372 (16) |
| dithiothreitol | NA | chemical reagent | NA | 6.00e-02 | 1.0e-02 | ATF3,GADD45A,HMOX1,MYC,NR0B2,SELE | 482 (20) |
| C-21 | NA | chemical drug | NA | 6.00e-02 | 1.0e-02 | Ccl2,CX3CR1,MMP9,TIMP1 | NA |
| piceatannol | NA | chemical - endogenous non-mammalian | NA | 6.00e-02 | 0.0e+00 | BCL2L1,CCL2,Ccl2,HMOX1,MMP9,MYC,PTGS2 | 402 (17) |
| TCF12 | -2.20e-01 | transcription regulator | NA | 5.00e-02 | 0.0e+00 | ASB2,AZGP1,CCL28,CCR9,CD200R1L,CD3G,CDKN1A,GFI1,GJB2,GLUL,IL21R,IL2RB,IRF4,ITGB7,LCK,LMO4,NGFR,PAX5,PTPRCAP,SEMA7A,ST8SIA1,STK17B,TNFRSF8,VIPR2,ZBTB16,ZC3H12A | 90 (4) |
| gefitinib | NA | chemical drug | NA | 5.00e-02 | 0.0e+00 | ADAMTS1,ADAMTS15,AURKB,BCL2L1,BTG2,CCL2,Ccl2,CD274,CEBPD,CXCL2,EGR3,EPGN,EZH2,FOSL1,FRAT2,GADD45B,GLI1,HMOX1,HYAL3,ID4,IL1R2,LPIN1,MAFF,MAP2K6,MMP9,MYCN,OSMR,PCDH12,PLAUR,PPP2R2B,PRKCG,PTGER1,PTGS2,RAD18,SMO,STAT1,TIMP3,TNFSF10 | 472 (17) |
| PPARD | 4.70e-01 | ligand-dependent nuclear receptor | NA | 5.00e-02 | 0.0e+00 | ADORA1,ADORA2A,ANGPTL3,APOB,AQP3,BCL2L1,Ccl2,CFAP54,CPT1A,CPT1B,CXCL2,CXCL3,CYP46A1,CYP7B1,FABP3,FASN,GLI1,HSD11B2,IFI44L,IKBKE,IL12B,Irgm1,LPIN2,MERTK,MMP9,Pcp4l1,PDE4C,PDK4,PLAT,PNPLA2,PPARGC1B,PTGS2,RASGRP1,SAT1,SLC2A10,STAT1,STBD1,TBX21,TCEA3,THBS1,Tlr12,TLR5,TNFRSF12A,TRIM63,UBC | 508 (19) |
| ARNT | 1.20e-01 | transcription regulator | NA | 5.00e-02 | 0.0e+00 | ACER2,BHLHE40,BLK,CD274,CXCL10,CXCR4,CYP2S1,EDN1,ESRRG,GADD45B,HK2,HNF4A,IL1R2,MYC,PRF1,SELL,SERPINE1,SOCS2,SOCS3,SOX2,TNFRSF19 | 559 (23) |
| conjugated linoleic acid | NA | chemical drug | NA | 5.00e-02 | 0.0e+00 | BCL2L1,CBS/LOC102724560,CPT1B,CXCR4,DUSP1,FOS,GCLC,MMP9,PPARGC1B,PTGS2,SOCS3,TNFSF8 | 508 (18) |
| IL6ST | 3.20e-01 | transmembrane receptor | NA | 5.00e-02 | 0.0e+00 | ALB,BCL2L1,CCL19,Ccl2,FGA,HPX,IL6R,JUNB,MYC,SERPINE1,SOCS3,TIMP1,TRPA1 | 371 (19) |
| TREM2 | NA | transmembrane receptor | NA | 4.00e-02 | 0.0e+00 | Ccl2,CTSV,CX3CR1,CXCL2,DKK2,FZD9,IL12B,IL1A,LGALS3,LOX,NFKBIA,PTGS2 | 537 (17) |
| Smad | NA | complex | NA | 4.00e-02 | 0.0e+00 | CDKN1A,ID4,MYC,SERPINE1,TBX21,WNT5A | 328 (13) |
| diethylnitrosamine | NA | chemical toxicant | NA | 4.00e-02 | 0.0e+00 | ALB,APCS,AURKB,BAAT,BCL2L1,C9,Ccl2,CDKN1A,CREB1,CXCL10,CYP7B1,GLI1,HMOX1,HNF4A,IL1A,LCN2,Mt1,MYC,S100A8,SELENBP1,SESN2,TIMP1 | 515 (19) |
| CCL5 | -2.40e-01 | cytokine | NA | 3.00e-02 | 0.0e+00 | ADGRE5,ATF4,CCL2,Ccl2,CCL4,CCR3,CD163,CHRNA7,CXCL2,CXCL3,DUSP1,F2RL1,FOS,GFI1,HDC,MMP9,PLAUR,STAT1,THBS1,ZFP36 | 477 (18) |
| lipoteichoic acid | NA | chemical - endogenous non-mammalian | NA | 3.00e-02 | 0.0e+00 | BCL2L1,CCL2,Ccl2,CD14,CD83,CXCL10,CXCR4,HMOX1,IL12B,MMP9,POU2AF1,PTGS2,SELP,SLC16A3 | 273 (12) |
| SLC9A3R1 | 1.50e-01 | transporter | NA | 3.00e-02 | 0.0e+00 | ABCC2,CCL24,CCL4,CXCL2,CXCL3,CXCL6,ERBB3,IL33 | 448 (20) |
| THRB | -7.80e-01 | ligand-dependent nuclear receptor | NA | 3.00e-02 | 0.0e+00 | ANGPTL3,BTG2,CCL17,CCL2,Ccl2,CCR6,CDH6,CLEC10A,CPT1A,CTSH,CXCL10,CXCL2,CXCL3,CXCR4,DIO1,ERBB3,FASN,FOS,FOSL1,FZD9,GHRHR,HCN4,HEPACAM,IL1A,IL24,MACC1,MMP9,MYC,NR5A2,Oasl2,P2RY14,PCK1,PDK4,PER1,POR,PTGS2,SERPINE1,TCEA3,THRB,TNFSF10,TRH,VSTM5,WNT11,WNT7A | 526 (21) |
| cholesterol | NA | chemical - endogenous mammalian | NA | 2.00e-02 | 0.0e+00 | ABCB11,Acot1,ADGRE1,APCS,APOB,ATF3,ATF4,CAMK1D,CCL2,Ccl2,CCL4,CD14,CD5L,CPT1A,CXCL10,CXCL2,CXCL3,CYP7B1,F3,FABP3,FASN,GLI1,IL12B,IL1A,INHBA,KCNA5,LGALS3,MAP1LC3B,Meis1,MMP8,NR0B2,PPARA,PPARGC1B,PSAT1,PTGS2,RGCC,RGS16,S100A8,SLC28A3,SLC7A5,SMO,SOCS3,THBS1,TIMP1,TIMP3,ZFPM2 | 531 (20) |
| IFN type 1 | NA | group | NA | 2.00e-02 | 0.0e+00 | BCL2L1,Ccl2,CD69,CXCL10,IFIT1,IL12B,IL22RA1,ISG15,MMP9,STAT1,TNFSF10,UBA7,XDH | 256 (16) |
| FGF7 | -1.70e-01 | growth factor | NA | 0.00e+00 | 0.0e+00 | BCL2L1,CDKN1A,CEBPD,FASN,HAS3,IL1A,LTA,MMP9,S100A8,SERPINE1,SFTPB,STAT1 | 460 (19) |
| PPIF | 1.70e-01 | enzyme | NA | 0.00e+00 | 0.0e+00 | ACKR4,BMP6,CCL2,Ccl2,CCL4,CCR6,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DLK1,HCAR1,LIF,MGP,PDK4,SPON2,WNT5A,XCL1 | 289 (11) |
| NEK7 | -2.20e-01 | kinase | NA | 0.00e+00 | 0.0e+00 | CXCL10,EDN1,ISG15,LMO4,PTGS2,RGCC | 316 (10) |
| PLC | NA | group | NA | 0.00e+00 | 0.0e+00 | CCL2,CD40LG,CXCL10,EGR3,FOS,MYC,ODC1,PTGS2 | 408 (17) |
| ADGRE2 | NA | other | NA | 0.00e+00 | 0.0e+00 | CCL2,CD274,CDKN1A,CXXC5,FOS,GLUL,HMOX1,MYC,SFN,WNT5A | 287 (7) |
| IMMT | -1.20e-01 | other | NA | 0.00e+00 | 0.0e+00 | CXCL10,CXCL2,CXCL3,CXCL6,IFIT1,INHBA,ISG15,MX1,OAS2,SERPINE1 | 457 (17) |
| PAF1 | 1.10e-01 | other | NA | 0.00e+00 | 0.0e+00 | ARL4A,IFI44,IFI44L,ISG15,LRRN3,Meis1,OAS2,PLAUR,SDC4,SERPINE1,ZFP36 | 259 (7) |
| PAX5-ELN | NA | fusion gene/product | NA | 0.00e+00 | 0.0e+00 | CD180,IGSF10,IL2RB,IRS1,KDR,MUC13,NKD2,RAPGEF3,RGS18,TGFBR3 | NA |
| 1-naphthylisothiocyanate | NA | chemical toxicant | NA | 0.00e+00 | 0.0e+00 | ABCB11,ABCC2,F3,NR0B2,SLC10A1,Slco1a1 | 97 (7) |
| NCOR2 | 4.00e-02 | transcription regulator | NA | 0.00e+00 | 0.0e+00 | ABCB11,AR,CD69,CDKN1A,DIO1,FOS,IL12B,IL1A,MYC,PDGFB,PTGS2,TRH | 483 (23) |
| cilostazol | NA | chemical drug | NA | 0.00e+00 | 0.0e+00 | CCL2,CLDN5,ERN1,HMOX1,KDR,MMP9,RAPGEF3,SELE,SELP,SERPINE1 | 490 (21) |
| CYLD-AS1 | NA | other | NA | 0.00e+00 | 0.0e+00 | ABCC2,FTL,GCLC,HMOX1,IL1A,JUNB,LGALS3,NFKBIA,PPARGC1B,TNFAIP6,TNFAIP8L3,TXNRD1 | 318 (7) |
| CBX5 | -3.60e-01 | transcription regulator | NA | 0.00e+00 | 0.0e+00 | ABCB1,AGR2,BCL11A,CDKN1A,CEMIP,FGFBP1,ITGA7,KRT80,LCN2,LTB,MUC13,RNF39,SELENBP1,SLC2A10,SLC7A7,SNTB1,SYTL2,TXNIP | NA |
| P2RY4 | 2.10e-01 | G-protein coupled receptor | NA | 0.00e+00 | 0.0e+00 | MMP8,MMP9,SELE,TIMP1 | 278 (7) |
| H2AB3 (includes others) | NA | other | NA | 0.00e+00 | 0.0e+00 | AQP3,ATF3,BLK,CDKN1A,FOS,ICAM5,JAK3,SLC30A3,TNFRSF8,TRAF3IP3 | 210 (7) |
| TEAD3 | 3.00e-01 | transcription regulator | NA | 0.00e+00 | 0.0e+00 | BBOX1,EDN1,EDNRA,FIBIN,FJX1,GPR37,KAZN,LOXL1,PTPRO,THBS1 | NA |
| SLC13A1 | NA | transporter | NA | 0.00e+00 | 0.0e+00 | C9,CD163,CHST7,Cyp3a25 (includes others),EDEM1,G0S2,GBP2,HK2,Igtp,KHDRBS3,MKKS,Mt1,NRN1,PCK1 | NA |
| SAFB | 4.00e-02 | other | NA | 0.00e+00 | 0.0e+00 | CXCL10,FOS,GULP1,HMOX1,LTB,MAP3K8,NEDD9,NUPR1,S100A8,TNFSF10 | 500 (15) |
| PRC2 | NA | complex | NA | 0.00e+00 | 0.0e+00 | BMP2,FGFBP1,IL1A,IRF4,KDR,MX1,Nes,PPP2R2B,RASSF1 | 401 (12) |
| 11-dehydrocorticosterone | NA | chemical - endogenous mammalian | NA | 0.00e+00 | 0.0e+00 | CPT1B,FASN,PDK4,PNPLA2 | 260 (9) |
| BLVRA | -1.00e-02 | enzyme | NA | 0.00e+00 | 0.0e+00 | CXCL10,HMOX1,PPARA,TNFSF10 | 472 (16) |
| tryptase | NA | group | NA | 0.00e+00 | 0.0e+00 | CXCL10,F2RL1,MMP9,PLAT | 429 (15) |
| adapalene | NA | chemical drug | NA | 0.00e+00 | 0.0e+00 | CCL2,Ccl2,CCL4,CXCL2 | 375 (13) |
| PDGF-DD | NA | complex | NA | 0.00e+00 | 0.0e+00 | Ccl2,EGR3,KDR,PGF,Pmaip1,TNFRSF12A | 192 (7) |
| PF-4457845 | NA | chemical drug | NA | 0.00e+00 | 0.0e+00 | FOS,LCN2,MMP9,S100A8 | NA |
| CD80 | -1.30e-01 | transmembrane receptor | NA | 0.00e+00 | 0.0e+00 | BCL2L1,CBLB,CD27,CD28,CD40LG,CD69,IL2RB,TBX21 | 353 (19) |
| Stat1 dimer | NA | complex | NA | 0.00e+00 | 0.0e+00 | CIITA,CXCL10,DUSP1,MAOA,SOCS3,TBX21 | 355 (12) |
| S-(2,3-bispalmitoyloxypropyl)-cysteine-GDPKHPKSF | NA | chemical reagent | NA | 0.00e+00 | 0.0e+00 | CCL2,CCL4,CXCL10,MMP9,PTGS2,SERPINE1 | 442 (16) |
| LATS2 | -2.00e-02 | kinase | NA | 0.00e+00 | 0.0e+00 | AURKB,CD14,CDKN1A,CLDN4,DHH,ERBB3,EREG,IGSF9B,Nes,PTGS2 | 288 (11) |
| SAA1 | NA | transporter | NA | 0.00e+00 | 0.0e+00 | CCL17,Ccl2,CCL4,CXCL10,CXCL6,IL12B,MMP9,S100A8 | 372 (14) |
| KDM3B | 2.60e-01 | enzyme | NA | 0.00e+00 | 0.0e+00 | ADAMTS1,ANKRD13A,ARG2,CDH26,DIO1,IRS1,KIF26B,NEDD4L,PRUNE2,SDCBP2,ZSCAN18 | NA |
| resolvin E1 | NA | chemical - endogenous mammalian | NA | 0.00e+00 | 0.0e+00 | Ccl2,CCL4,CXCL2,HMOX1,IL12B,IRS1 | 300 (16) |
| DDIT4 | 1.33e+00 | other | NA | 0.00e+00 | 0.0e+00 | CCL2,Ccl2,CXCL10,FASN,IL33,MAP1LC3B,NFKBIA | 455 (19) |
| calyculin A | NA | chemical toxicant | NA | 0.00e+00 | 0.0e+00 | CCL2,CDKN1A,GNAI2,IL21R,ODC1,SELP | 449 (23) |
| RUNX1-RUNX1T1 | NA | fusion gene/product | NA | 0.00e+00 | 0.0e+00 | AFF3,ARG2,ASPA,ATF3,CDKN1A,CYP2S1,ERN1,GRK5,IL6R,PXDC1,RND3,RNF144A,SCN1B,TGFA,ZBTB16 | 287 (7) |
| antimycin A | NA | chemical - endogenous non-mammalian | NA | 0.00e+00 | 0.0e+00 | CPT1B,SELL,TIMP1,Tnfsf9,TXNIP | NA |
| NMU | 4.00e-02 | other | NA | 0.00e+00 | 0.0e+00 | ATF4,BTG2,DIO2,IL1R2,Mt1,TNFRSF8 | 376 (13) |
| 7(R)-maresin 1 | NA | chemical - endogenous mammalian | NA | 0.00e+00 | 0.0e+00 | Ccl2,CCL4,CXCL2,CXCL3,HMOX1,STAT1 | 320 (13) |
| ZFAS1 | NA | other | NA | 0.00e+00 | 0.0e+00 | FASN,MMP16,NKD2,ZEB2 | NA |
| LATS1 | 3.00e-02 | kinase | NA | 0.00e+00 | 1.0e-02 | CD14,CLDN4,DHH,ERBB3,EREG,IGSF9B,Nes,PTGS2 | NA |
| FH | -8.00e-02 | enzyme | NA | 0.00e+00 | 1.0e-02 | ATF4,CDKN1A,HMOX1,UGT2B10 | NA |
| PTPRE | -1.40e-01 | phosphatase | NA | 0.00e+00 | 1.0e-02 | CXCL2,CXCL3,INHBA,PLA1A | NA |
| TIMP3 | 7.30e-01 | other | NA | 0.00e+00 | 1.0e-02 | FOS,MMP9,SERPINE1,STAT1,TGFBR3,THBS1,WNT11,ZEB2 | 407 (18) |
| 2,4,5,2’,4’,5’-hexachlorobiphenyl | NA | chemical toxicant | NA | 0.00e+00 | 1.0e-02 | CLDN5,CREM,Cyp3a25 (includes others),FASN,GADD45A,GADD45B,HSD17B2,Mx2,MYC,SLC23A1,SMPD3,TRA2A,WNK2 | NA |
| digoxin | NA | chemical drug | NA | 0.00e+00 | 1.0e-02 | ABCB1,ADORA2B,CPT1B,FASN | NA |
| sea cucumber body wall meal | NA | chemical reagent | NA | 0.00e+00 | 1.0e-02 | CPT1A,FASN,PPARA,PPARGC1B | NA |
| RGS2 | -1.80e-01 | enzyme | NA | 0.00e+00 | 1.0e-02 | AQP3,BCAR3,BTG2,CEBPD,ERRFI1,F3,GRINA,HSD11B2,MKNK2,PLAT,PLXND1,SLC16A3 | 252 (7) |
| tributyltin | NA | chemical reagent | NA | 0.00e+00 | 1.0e-02 | CYP26B1,DKK2,F2RL1,IL33,INHBA,ITGB7,KRT80,PDK4,PPARA,PPL,SNTB1,SPN,STAT1,THBS1 | NA |
| IL-17f dimer | NA | complex | NA | 0.00e+00 | 1.0e-02 | CCL2,CCL4,IL1A,LCN2 | NA |
| ACSL5 | -6.00e-02 | enzyme | NA | 0.00e+00 | 1.0e-02 | GFPT2,MCAM,MYRIP,PPP4R4 | NA |
| allyl sulfide | NA | chemical drug | NA | 0.00e+00 | 1.0e-02 | Gsta1,HMOX1,Slco1a1,TRPC3 | NA |
| oxysterol | NA | chemical - endogenous mammalian | NA | 0.00e+00 | 1.0e-02 | CCL2,Ccl2,MYC,TIMP1 | NA |
| RNASEL | -3.00e-01 | enzyme | NA | 0.00e+00 | 1.0e-02 | CDKN1A,FZD10,ISG15,OAS2,PTGS2,USP18 | NA |
| risperidone | NA | chemical drug | NA | 0.00e+00 | 1.0e-02 | BCL2L1,CXCL10,FOS,NGFR,TBX21 | NA |
| geranylgeranyl pyrophosphate | NA | chemical - endogenous mammalian | NA | 0.00e+00 | 1.0e-02 | BMP2,CCL2,MMP9,PPARA,PTGS2 | NA |
| NCR2 | NA | transmembrane receptor | NA | 0.00e+00 | 1.0e-02 | CCL4,PTGS2,THBS1,XCL1 | NA |
| TPCA-1 | NA | chemical drug | NA | 0.00e+00 | 2.0e-02 | CCL2,IL1A,MMP9,MYC | NA |
| miR-130a-3p (and other miRNAs w/seed AGUGCAA) | NA | mature microRNA | NA | 0.00e+00 | 2.0e-02 | CXCL2,CXCL3,MEOX2,ZFPM2 | NA |
| WWOX | 2.40e-01 | enzyme | NA | 0.00e+00 | 2.0e-02 | BCL2L1,HAS1,MMP9,TP73 | NA |
| lycopene | NA | chemical drug | NA | 0.00e+00 | 2.0e-02 | CD69,CDKN1A,MMP9,PTGS2 | NA |
| TET3 | -1.50e-01 | enzyme | NA | 0.00e+00 | 2.0e-02 | ADAMTS9,Akap17b,PHOSPHO1,POR,SOX2,TBX6 | NA |
| GABARAP | 1.70e-01 | transporter | NA | 0.00e+00 | 2.0e-02 | CXCR4,NPC2,PDGFB,TRPV1,UPP1 | NA |
| ZBP1 | -8.30e-01 | other | NA | 0.00e+00 | 2.0e-02 | CXCL10,IL33,ISG15,NFKBIA | NA |
| GNAI3 | 5.40e-01 | enzyme | NA | 0.00e+00 | 2.0e-02 | CCL2,CCL4,CXCL3,IL24 | NA |
| CCR6 | -7.80e-01 | G-protein coupled receptor | NA | 0.00e+00 | 2.0e-02 | Ccl2,CD40LG,CXCL10,IL12B | NA |
| ADORA3 | NA | G-protein coupled receptor | NA | 0.00e+00 | 2.0e-02 | CCL2,CCL4,CXCL3,IL24 | NA |
| ITGA9 | 1.20e-01 | other | NA | 0.00e+00 | 3.0e-02 | Ccl2,CCL4,CCR6,CXCL6 | NA |
| SETX | -1.90e-01 | enzyme | NA | 0.00e+00 | 4.0e-02 | CTSV,CYP26B1,KRT17,KRT75 | NA |
| LRPAP1 | 2.00e-01 | other | NA | 0.00e+00 | 4.0e-02 | Ccl2,F3,PTGS2,SERPINE1 | NA |
| HDAC6 | 3.90e-01 | transcription regulator | NA | 0.00e+00 | 4.0e-02 | ADAMTS1,AR,JUNB,MYC,PDGFB,SERPINE1 | NA |
| TAF7L | 1.40e-01 | transcription regulator | NA | 0.00e+00 | 5.0e-02 | AK1,AR,EGR3,LPIN1,SPATA21,SPATC1 | NA |
| arotinoid acid | NA | chemical toxicant | NA | 0.00e+00 | 5.0e-02 | CDKN1A,DUSP1,FOS,ODC1 | NA |
| triamcinolone acetonide | NA | chemical drug | NA | -1.00e-02 | 0.0e+00 | ACKR4,AQP1,AQP3,ATF3,BCL2A1,BHLHE40,BMP2,BMP6,BMP7,BTG2,CD22,CD79B,DUSP1,EDNRA,ELK3,EPHA4,F10,FKBP5,FOS,GZMA,HIPK2,JUNB,KCNJ12,KLF15,MYC,NFKBIA,PER1,PRF1,RGCC,RGS16,SOAT1,SOCS2,TRIB1,TXNIP,ZBTB16,ZNF189 | 410 (15) |
| PRMT5 | 1.60e-01 | enzyme | NA | -1.00e-02 | 0.0e+00 | CD274,CXCL10,FASN,MYC,PER1,PPARA,PTPRO,PTX3,SOSTDC1,SOX2,STAT1 | 490 (22) |
| SPHK1 | 2.18e+00 | kinase | NA | -2.00e-02 | 0.0e+00 | BCL2L1,CCL17,Ccl2,CDKN1A,ERN1,IL33,MAP2K6,PTGS2,SELP,SERPINE1,SOCS3,SPHK1,TIMP1 | 470 (17) |
| PNPLA2 | 1.01e+00 | enzyme | NA | -2.00e-02 | 0.0e+00 | Acot1,ADGRE1,Ccl2,CPT1A,CPT1B,FASN,GPR3,IRS1,PCK1,PDK4,PLIN5,PNPLA2,PPARA,PPARGC1B,TRIM63 | 524 (22) |
| urethane | NA | chemical toxicant | NA | -3.00e-02 | 1.0e-02 | CD274,CDKN1A,HMOX1,KDR,MYC,PTGS2 | 396 (18) |
| PIM2 | 3.00e-02 | kinase | NA | -3.00e-02 | 2.0e-02 | MYC,SELL,TBX21,TP73 | NA |
| lipoxin A4 | NA | chemical - endogenous mammalian | NA | -3.00e-02 | 0.0e+00 | CCL2,Ccl2,CDKN1A,HMOX1,PTGS2,SELE,SERPINE1,TIMP1 | 504 (21) |
| androgen | NA | chemical drug | NA | -3.00e-02 | 0.0e+00 | ADAMTS15,AGR2,AR,BMP6,BTG2,CA12,CRP,CTSV,CX3CR1,CXCR4,ERBB3,F9,FOS,FOSL1,INHBA,MMP9,Mt1,MYC,NFKBIA,PRKCB,PTGS2,PTPRC,SDC4,SOAT1,WNT5A | 398 (18) |
| CD4 | -1.50e-01 | transmembrane receptor | NA | -3.00e-02 | 0.0e+00 | BCL2L1,CD79A,F3,JAK3,LCK,TBX21,TNFSF10 | 416 (19) |
| trametinib | NA | chemical drug | NA | -4.00e-02 | 0.0e+00 | CD274,IFIT1,ISG15,MX1,MYBPH,MYC,ROR2,SOCS3,TNFSF10 | 427 (19) |
| GW501516 | NA | chemical drug | NA | -4.00e-02 | 0.0e+00 | Acot1,CDKN1A,CPT1A,CPT1B,CXCL6,F3,FABP3,FASN,IL1A,LPIN1,PDK4,PLAT,PPARA,PPL,PTGS2,S100A8,THBS1 | 519 (23) |
| ORMDL3 | 4.00e-02 | other | NA | -4.00e-02 | 3.0e-02 | CXCL10,MAP1LC3B,MMP9,OAS2 | NA |
| dehydroisoandrosterone | NA | chemical - endogenous mammalian | NA | -4.00e-02 | 0.0e+00 | AQP3,AR,Ccl2,CD3G,CPT1A,Cyp4a14,FKBP5,IL12B,KCNA5,LGALS3,MYC,NFKBIA,POR,SELE,STEAP2 | 508 (20) |
| Creb | NA | group | NA | -4.00e-02 | 0.0e+00 | ATF3,BMP6,C3AR1,CD14,CD5L,CDKN1A,CEBPD,CPT1A,CREM,CTSV,CXCL10,DUSP1,EGR3,ELL,FOS,FOSL1,IER3,IL33,JUNB,KCNA5,LMO4,MCAM,MUC5B,NEDD9,NRN1,OSBPL3,PCK1,PER1,PLAT,POU2AF1,PTGS2,RBFOX1,RYR2,TRH,UBC,ZBP1 | 553 (22) |
| Notch | NA | group | NA | -5.00e-02 | 0.0e+00 | ABLIM1,ADGRE1,ANKRD1,CCL19,CDCA7,CDKN1A,CLEC10A,CSF3R,CXXC5,DUSP1,GADD45B,GZMA,HEYL,KBTBD11,MEX3B,MYC,Nes,PIK3IP1,RGCC,SOX2,SRFBP1,TBX21,TGM1,ZEB2 | 459 (19) |
| NTRK3 | -8.00e-01 | kinase | NA | -5.00e-02 | 0.0e+00 | BCL2L1,CDKN1A,IL1A,NTRK3,SERPINE1,SOX2 | 473 (22) |
| WNT3A | -6.00e-02 | cytokine | NA | -5.00e-02 | 0.0e+00 | Acan,ADAMTS4,AQP3,ATP1B1,BMP2,CCL2,Ccl2,CD274,COL2A1,CPT1B,CXCL10,CXCL2,CXCL3,DDIT4,DKK2,DLK1,EDN1,ERBB3,FCMR,GADD45G,GLI1,HAS3,IL12B,IL1A,Irgm1,IRS1,KDR,LCN2,LGALS12,LRRC17,LRRC32,Meis1,MMD,MRGPRF,MYC,Nes,NGFR,NR5A2,PNPLA3,PROCR,PTGS2,RUNX1T1,SDC4,SERPINB1,SGMS1,SLC7A1,THBS1,TIMP3,TNFRSF19,Tnfsf9,TXNIP,WNT11,WNT5A,WNT7A | 442 (19) |
| CpG ODN 2395 | NA | chemical reagent | NA | -5.00e-02 | 0.0e+00 | Ccl2,CCL4,CD14,FCER2,HMOX1,IL12B,IL4R,TNFRSF13C | 426 (16) |
| TGM2 | 8.00e-02 | enzyme | NA | -5.00e-02 | 0.0e+00 | Acan,BCL2A1,BTG2,CCL2,CCL24,CD101,CD300C,CDCA7,CSRNP1,CX3CR1,CXCL10,CYP2R1,FERMT1,IFIT1,MERTK,MGP,MMP8,MMP9,MYC,NPC2,OAS2,POR,RNF213,RTKN2,S100A8,SELL,SELP,SEMA6B,SEMA7A,STAT1,THBS1,UBA7 | 405 (22) |
| PROCR | 9.40e-01 | other | NA | -6.00e-02 | 0.0e+00 | Ccl2,GBP2,GBP4,LIF,MMP9,MYC | 422 (19) |
| leukotriene C4 | NA | chemical - endogenous mammalian | NA | -6.00e-02 | 0.0e+00 | CCL2,CCL4,EGR3,FOS,PTGS2,SELP | 403 (17) |
| CXCR2 | -2.30e-01 | G-protein coupled receptor | NA | -6.00e-02 | 0.0e+00 | BCL2L1,Ccl2,CXCL10,CXCL2,CXCL3,IFRD1,MUC5B | 430 (17) |
| IMD-0354 | NA | chemical reagent | NA | -6.00e-02 | 2.0e-02 | AR,Ccl2,CLDN4,SOX2 | NA |
| NCOA2 | -2.70e-01 | transcription regulator | NA | -6.00e-02 | 0.0e+00 | ABCB11,ADORA1,AR,BMP2,Ccl2,CCL4,CDKN1A,CIITA,CXCL10,FASN,GBP5,IL1A,IRF4,ISG15,LPIN1,NFKBIA,PCK1,PPP1R3C,PTGS2,SFTPB | 537 (22) |
| OGA | NA | enzyme | NA | -6.00e-02 | 0.0e+00 | ABLIM1,ADAMTS5,ADGRG2,ADGRL2,AZGP1,BCL2L1,C3AR1,CALCRL,CAMK1D,CCL2,Ccl2,CD14,CDCA7,CDH15,CDKN1A,CX3CR1,CXCL6,EPHA4,ERBB3,FABP3,FGFBP1,FGFR4,FZD10,GADD45A,GADD45G,GLUL,GTF3A,HIPK2,IL21R,IL6R,ITGB7,KRT81,LIF,MCAM,OGT,PDHA1,PECR,PRF1,RBP4,SOCS2,SOCS3,SOX2,SRPK3,STAT1,TGFA,TGFBR3,THBS1,TIMP1,TIMP3,TNFRSF12A,TP73,TRH,WNT11 | 498 (21) |
| VEGFC | -3.70e-01 | growth factor | NA | -6.00e-02 | 1.0e-02 | Ccl2,CXCR4,KDR,PTGS2 | 404 (18) |
| N-(3-oxododecanoyl)-homoserine lactone | NA | chemical reagent | NA | -6.00e-02 | 1.0e-02 | CXCL2,CXCL6,IL1A,PTGS2 | 473 (15) |
| protectin D1 | NA | chemical - endogenous mammalian | NA | -7.00e-02 | 1.0e-02 | BCL2A1,BCL2L1,HMOX1,PTGS2 | NA |
| mir-204 | NA | microRNA | NA | -7.00e-02 | 4.0e-02 | ATF4,BMP2,CHRNA7,CXCL2,FOXC1,MYC,PRKCG | NA |
| hemozoin | NA | chemical - endogenous non-mammalian | NA | -7.00e-02 | 0.0e+00 | CCL2,Ccl2,CCL4,CD83,CXCL2,CXCL3,CXCR4,HMOX1,IL1A,MMP9,S100A8 | 481 (15) |
| MITF | -2.00e-02 | transcription regulator | NA | -7.00e-02 | 0.0e+00 | APOLD1,ATP1A1,AURKB,CDKN1A,COL2A1,CREM,FANCG,FOS,GLI1,GZMB,IL6R,IRF4,KAZN,LGALS3,MGP,NGFR,PHACTR1,PLA1A,PRF1,SERPINE1,TBC1D16,TNFRSF14,TXNIP,UPP1,VSX2,XCL1 | 532 (27) |
| staurosporine | NA | chemical drug | NA | -7.00e-02 | 0.0e+00 | ABCB1,BCL2L1,BTG2,CCL4,CCR3,CD28,CDKN1A,CSF3R,ERBB3,FOS,FOSL1,HDC,HMOX1,ISG15,KCNA3,MMP9,MYC,NEDD9,ODC1,PCK1,PLAT,PTGS2,SELE,SELL,SERPINE1,TGFBR3 | 441 (20) |
| CLEC4E | -5.00e-02 | other | NA | -7.00e-02 | 0.0e+00 | ADGRE1,Ccl2,CCL4,CPT1A,CXCL2,CXCL3,IL12B | 278 (13) |
| zinc | NA | chemical drug | NA | -7.00e-02 | 1.0e-02 | HMOX1,HNF4A,MGP,Mt1,NFKBIA,NGFR,NRTN,PDE4A,PTGS2,SELENBP1 | NA |
| crizotinib | NA | chemical drug | NA | -8.00e-02 | 0.0e+00 | BCL2L1,CD274,ERBB3,FASN,HK2,OSMR,SERPINE1,TXNIP | 485 (22) |
| TEAD4 | 4.90e-01 | transcription regulator | NA | -8.00e-02 | 0.0e+00 | BBOX1,CDKN1A,EDN1,EDNRA,Elf5,FIBIN,FJX1,FKBP5,GPR37,JUNB,KAZN,LOXL1,MMP9,NFKBIA,PTPRO,THBS1 | 467 (15) |
| CALC | NA | group | NA | -8.00e-02 | 0.0e+00 | CCL2,CREM,EDN1,FOS,IL33 | 486 (20) |
| Laminin (complex) | NA | complex | NA | -8.00e-02 | 3.0e-02 | CCL2,MMP9,PTGS2,SDC4,SERPINE1,WNT5A | NA |
| INSIG1 | 4.60e-01 | other | NA | -8.00e-02 | 0.0e+00 | ATF3,ATF4,CCL17,CCR6,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DLK1,ERN1,FASN,IL12B,LCN2,LPIN1,PRF1,S100A8,STEAP2 | 327 (14) |
| RB1CC1 | 5.00e-02 | other | NA | -9.00e-02 | 0.0e+00 | CDKN1A,CXCL10,MYC,SERPINE1 | 501 (21) |
| Tnf (family) | NA | group | NA | -9.00e-02 | 0.0e+00 | ADAMTS5,ATF3,BCL2A1,BCL2L1,C3AR1,CCL2,Ccl2,CCL4,CD163,CD22,CD274,CIRBP,CLDN4,CXCL10,CXCL3,F3,FCER2,GFI1,IKBKE,IL12B,IL1A,IL1R2,IL33,INHBA,IRAK2,KDR,LCN2,MMP9,MYC,NFKBIA,PDGFB,PTGER3,PTGS2,SELE,SELL,SERPINE1,SOCS3,SPN,TNFAIP6,TNFRSF14,TRIM63 | 277 (13) |
| PTPN1 | 3.50e-01 | phosphatase | NA | -9.00e-02 | 0.0e+00 | ADRA1A,ADRA1D,ARID5A,CIDEA,CXCL2,CXCL3,DUSP1,EDEM1,FASN,FCER2,IRS1,NFKBIA,RILPL1,TMEM26 | 537 (23) |
| N,N-dimethylsphingosine | NA | chemical reagent | NA | -9.00e-02 | 0.0e+00 | FOS,PTGS2,SELE,SPHK1 | 439 (19) |
| PTPN3 | 1.00e-01 | phosphatase | NA | -9.00e-02 | 1.0e-02 | CDKN1A,MMP9,MYC,PDGFB,SERPINE1 | 490 (23) |
| FCGR2A | NA | transmembrane receptor | NA | -9.00e-02 | 0.0e+00 | CCL2,Ccl2,CCL4,CXCL10,CXCL2,CXCL3,F2RL1,GBP2,IL12B,ISG15,PTGS2,RASGRP1,SERPINE1,STAT1,USP18 | 422 (20) |
| glycine | NA | chemical - endogenous mammalian | NA | -9.00e-02 | 0.0e+00 | ALB,ATF4,CDKN1A,FOS,ODC1,PSAT1 | 485 (21) |
| SELPLG | -2.90e-01 | other | NA | -9.00e-02 | 0.0e+00 | BCL2A1,BTLA,CCL2,CCL4,CDKN1A,CXCL2,CXCR4,FOS,IL1R2,IL4R,LAG3,PLAUR | 485 (17) |
| IL31 | NA | other | NA | -1.00e-01 | 0.0e+00 | CCL2,IL33,JUNB,SOCS2,SOCS3,TRPA1 | 390 (19) |
| TRAF2 | 0.00e+00 | enzyme | NA | -1.00e-01 | 2.0e-02 | AURKB,CCL2,CR2,CXCL10,CXCL3,IKBKE,IRF4,MMP9,SELE,ST8SIA6 | NA |
| VDR | 1.70e-01 | transcription regulator | NA | -1.00e-01 | 0.0e+00 | ABCB11,ABL1,AGR2,BCL2L1,BMP2,BMP7,Ccl2,CD14,CDKN1A,CPT1A,CUBN,CXCL10,EDN1,EZH2,F3,FASN,GADD45A,GADD45G,GLI1,GNAI2,HK2,IER3,IFI44L,IL12B,IL1A,ISG15,ITGB7,MYC,NEDD9,NR0B2,NUPR1,ODC1,PNPLA2,PPARA,PPARGC1B,PTGS2,RGCC,RNF144A,S100A8,SELE,SERPINC1,SLC25A10,SLC30A10,SLC7A7,Slco1a1,SOCS3,TXNIP | 413 (19) |
| heme | NA | chemical - endogenous mammalian | NA | -1.00e-01 | 0.0e+00 | Ccl2,CCL4,CD14,CD163,CLDN5,CXCL10,CXCL2,CXCL3,CXCL6,HMOX1,IL12B,IL1A,LCN2,LIF,PER1,SELP | 454 (14) |
| CDKN2A | NA | transcription regulator | NA | -1.00e-01 | 0.0e+00 | AK1,AURKB,BCL11A,BCL11B,BTG2,CCL19,CCL2,Ccl2,CCL24,CCL4,CCNA1,CCR6,CCR9,CD19,CD274,CD40LG,CD79A,CD79B,CDKN1A,CEBPD,CRP,CXCL10,CXCL6,DUSP1,EHD3,EZH2,FASN,FGF11,FOS,GADD45G,GAS7,GLUL,HUNK,IL1A,IL1R2,IL6R,KCNK1,LGALS3,LTA,MMP9,MS4A1,MYC,MYCN,ODC1,P4HA2,PAX5,PGF,POU2AF1,PSAT1,PTGS2,PTX3,SERPINE1,SOX2,TGFA,TGFBR3,XCR1,ZBTB16 | 447 (15) |
| NR3C1 | -4.40e-01 | ligand-dependent nuclear receptor | NA | -1.00e-01 | 0.0e+00 | ABL1,ADH1C,ADRA1D,AQP1,ATP1B1,BCL2L1,BHLHE40,BMP2,C1QTNF1,CCL17,CCL2,Ccl2,CCL4,CD274,CD40LG,CD69,CD83,CDKN1A,CEBPD,CIDEA,CLDN5,CPB2,CPT1A,CSRNP1,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DDIT4,DNASE1L3,DUSP1,DYNLL1,EDN1,ENC1,ERN1,ERRFI1,F2RL1,F3,FKBP5,FOS,GADD45A,GADD45B,GBP2,GEM,GHRHR,GLP2R,GLUL,GNRH1,GULP1,GZMA,H6PD,HNF4A,HSD11B2,IER3,IL12B,IL1A,IL24,IL33,INHBA,ISG15,KRT17,LCN2,LGALS12,LIF,LMO4,LOX,LPIN1,LTB,MAOA,MKNK2,MLF1,MMP8,MMP9,Mt1,Mt1m/Mt2A,MYC,NFIL3,NFKBIA,NGFR,NME5,NR0B2,PCK1,PER1,PFKFB3,PLAT,PNPLA2,PPARA,PPP3R1,PRKCB,PTGS2,RAPGEF4,S100A8,SELE,SEMA5B,SERPINE1,SLC25A33,SLC2A5,SLC43A1,SLC7A6,STK17B,THBS1,TIMP1,TIMP3,TLE3,TLR5,TNFAIP6,TNFRSF12A,TNFRSF21,TNFRSF8,TNS4,TP53BP2,WNT5A,XCL1 | 571 (17) |
| levothyroxine | NA | chemical - endogenous mammalian | NA | -1.00e-01 | 1.0e-02 | ABCB1,CDKN1A,DIO1,DIO2,FASN,FOS,Gsta1,Nes,NGFR,Nrgn | 473 (26) |
| PLA2G2A | 3.90e-01 | enzyme | NA | -1.00e-01 | 1.0e-02 | CD69,PCK1,PLCD1,PTGS2 | NA |
| HNF1B | -6.00e-02 | transcription regulator | NA | -1.10e-01 | 1.0e-02 | ALB,BHLHE40,DUSP1,HNF4A,ID4,NR5A2,PDE4C,PLAUR,SERPINH1,SLC26A3,SLC5A1,Slco1a1,UPP1,ZEB2 | 94 (4) |
| ibrutinib | NA | chemical drug | NA | -1.20e-01 | 0.0e+00 | BCL2L1,CCNA1,CD69,CLDN11,GPR55,GZMA,HK2,MAP3K6,MYC,NELL2,ODC1,POU2F2,SELL,SLC2A5,TBRG4,TGFBR3 | 389 (16) |
| 101.10 peptide | NA | chemical reagent | NA | -1.20e-01 | 1.0e-02 | Ccl2,CRP,MMP9,PTGS2 | 389 (12) |
| TNFSF13B | 3.20e-01 | cytokine | NA | -1.20e-01 | 0.0e+00 | ADORA2A,ARG2,AURKB,BCL2A1,BCL2L1,BTLA,CCL2,CCL4,CD274,CD40LG,CD83,CR2,CXCL6,DAB2IP,F3,FCER2,FOSL1,GPR55,HSH2D,INHBA,MMP9,MYC,PGF,PGLYRP1,PLAUR,POU2AF1,SELL,SMO,THBS1,TNFAIP6,TNFRSF12A,TNFRSF8 | 515 (18) |
| dihydroartemisinin | NA | chemical drug | NA | -1.20e-01 | 1.0e-02 | CDKN1A,MMP9,MYC,PTGS2 | 418 (16) |
| estrogen receptor | NA | group | NA | -1.30e-01 | 0.0e+00 | BMP7,CA12,CCNA1,CDH15,CLDN4,CXCR4,EDN1,ERBB3,EREG,FGFR4,FOS,GAL,IL1A,IRS1,KRT7,MGP,MMP9,MYC,NEDD9,PCDH20,PDGFD,PDK4,PLAUR,POR,SAT1,SELL,SERPINE1,TGFA,TGFBR3,TIMP1,TIMP3,WNT5A | 595 (19) |
| PLAU | -2.10e-01 | peptidase | NA | -1.30e-01 | 0.0e+00 | BCL2L1,CCL2,Ccl2,CXCL3,F3,KDR,MMP9,PLAUR,PLG,PON1,S100A8,SERPINB1,SERPINE1 | 355 (18) |
| N4BP1 | 5.00e-02 | enzyme | NA | -1.30e-01 | 0.0e+00 | CCL4,CXCL2,CXCL6,IL12B,JUNB,TP73 | 444 (13) |
| MIR31HG | NA | other | NA | -1.30e-01 | 0.0e+00 | CDKN1A,CXCL2,EREG,IL1A,SERPINE1,TIMP1 | 421 (19) |
| NF1 | -1.70e-01 | other | NA | -1.30e-01 | 0.0e+00 | BCL2L1,CBS/LOC102724560,GLI1,MYC,PCK1,PDGFB,SELP | 454 (20) |
| FUS-DDIT3 | NA | fusion gene/product | NA | -1.30e-01 | 1.0e-02 | IL24,IL6R,LCN2,LOX,PTX3,SERPINE1,SOCS2 | 409 (12) |
| TIFA | 2.50e-01 | other | NA | -1.30e-01 | 0.0e+00 | BCL2L1,CCL2,CXCL10,CXCL3,NFKBIA | 377 (14) |
| TNFRSF1B | -3.40e-01 | transmembrane receptor | NA | -1.30e-01 | 1.0e-02 | APCS,BCL2L1,CD69,CXCL2,IL12B,MMP9,NR5A2,Podxl,SELL,SERPINE1,SOCS3,TGFA,TIMP1 | 551 (21) |
| ETV7 | NA | transcription regulator | NA | -1.30e-01 | 0.0e+00 | BMP6,CCL2,CCL24,IFITM2,PROCR,TRIM14 | NA |
| PHLPP2 | 3.40e-01 | enzyme | NA | -1.30e-01 | 0.0e+00 | CPT1A,IRS1,MAP1LC3B,PPARA,PRKCB | 359 (18) |
| YAP/TAZ | NA | group | NA | -1.40e-01 | 0.0e+00 | ATF4,CD274,IL1A,NFKBIA,PSAT1,PTGS2 | 208 (7) |
| mevalonic acid | NA | chemical - endogenous mammalian | NA | -1.40e-01 | 0.0e+00 | CCL2,CD40LG,FASN,MYOCD,PLAT,PPARA,PTGS2,SERPINE1 | 503 (17) |
| PRKCI | -5.60e-01 | kinase | NA | -1.40e-01 | 0.0e+00 | CD274,CLDN4,CXCL10,CXCL2,CXCL3,FASN,HK2,HMOX1,IL1A,KCNJ11,STAT1 | 401 (15) |
| CGS 21680 | NA | chemical reagent | NA | -1.40e-01 | 0.0e+00 | ADORA2A,Ccl2,CCL4,CD40LG,CD69,EGR3,F3,FOS,IL12B,PTGS2 | 410 (18) |
| BCL2 | -9.00e-02 | transporter | NA | -1.40e-01 | 0.0e+00 | Acan,BCL2L1,CDKN1A,COL2A1,CTSH,FOS,GADD45A,GCLC,GZMA,IL12B,MCAM,MMP9,NFKBIA,PLAUR,PRF1,SPHK1,TIMP1 | 468 (18) |
| RIPK1 | 5.00e-01 | kinase | NA | -1.50e-01 | 1.0e-02 | CCL2,Ccl2,CXCL10,CXCL2,IL12B,IL33,MMP9,PDGFB,WNT5A | 413 (19) |
| galactosylceramide-alpha | NA | chemical reagent | NA | -1.50e-01 | 1.0e-02 | CCL2,Ccl2,CD40LG,CD69,CXCL3,JUNB,LGALS3,NRP1 | NA |
| diallyl trisulfide | NA | chemical - endogenous non-mammalian | NA | -1.50e-01 | 3.0e-02 | BCL2L1,CDKN1A,FOS,HMOX1 | NA |
| AKT2 | -3.00e-02 | kinase | NA | -1.50e-01 | 4.0e-02 | Ccl2,CDKN1A,CIDEA,GCLC,MMP9,MYCN,TIMP1 | NA |
| IL33 | -1.54e+00 | cytokine | NA | -1.50e-01 | 0.0e+00 | ADAMTS1,Adgre4,ADORA2B,APOLD1,ATP8B4,BCL2A1,BCL2L1,BPIFB1,CCL17,CCL2,Ccl2,CCL4,CD28,CD69,CD83,CREM,CSF3R,CXCL10,CXCL2,CXCL3,EGR3,FOSL2,FTL,G0S2,GADD45B,GFI1,GJB1,HDC,HMOX1,IER3,IKBKE,IKZF3,IL1A,IL2RB,IL33,IL4R,JUNB,LAMA5,LMO4,Milr1,MMP9,MUC5B,MYC,NFIL3,NFKBIA,NRP1,ODC1,P4HA1,PDGFB,PLAT,POU2F2,PSAT1,PTPRC,RAMP3,RASGRP1,S100A8,SDC4,SERPINB1,SERPINE1,SIGLEC8,SLC11A1,SOCS3,SOX2,TGFA,TIMP1,TNFRSF18,TNFSF10,TPBG,ZC3H12A,ZEB2,ZFP36 | 516 (17) |
| mir-146 | NA | microRNA | NA | -1.50e-01 | 0.0e+00 | CCL2,Ccl2,CD163,CXCL10,CXCL3,DUSP1,EVI2B,F3,FOS,HK2,IRAK2,ISG15,MMP9,MYC,NFYA,NPRL3,PTGS2,STAT1 | 412 (13) |
| PTGER2 | 5.30e-01 | G-protein coupled receptor | NA | -1.50e-01 | 0.0e+00 | ADGRE1,ALB,CXCL10,CXCR4,HDC,IL1A,IL1R2,KLRD1,LIF,MMP9,PBK,PTGER3,PTGS2,SERPINE1,THBS1,TIMP1,TIMP3,TNFAIP6 | 448 (21) |
| andrographolide | NA | chemical drug | NA | -1.50e-01 | 0.0e+00 | AR,BCL2L1,HMOX1,MMP9,PTGS2,RGN,SELE,TIMP1 | 427 (17) |
| LYN | 8.00e-02 | kinase | NA | -1.50e-01 | 0.0e+00 | BCL2A1,Ccl2,CCL4,CD19,CD22,CDKN1A,CR2,IL1A,MYC,NFKBIA,SOCS3,SPHK1,TNFRSF14 | 421 (19) |
| KT5720 | NA | chemical drug | NA | -1.50e-01 | 0.0e+00 | ADORA2A,HMOX1,NFKBIA,POU2AF1 | 401 (9) |
| SPINT1 | 1.20e-01 | other | NA | -1.50e-01 | 1.0e-02 | APCDD1,ROR2,WNT11,WNT5A | NA |
| morin | NA | chemical - endogenous non-mammalian | NA | -1.50e-01 | 1.0e-02 | BCL2L1,MMP9,PTGS2,TIMP1 | 408 (13) |
| PURPL | NA | other | NA | -1.50e-01 | 1.0e-02 | CNTRL,DIO2,MAP1LC3B,OAS2 | NA |
| CEP-1347 | NA | chemical drug | NA | -1.50e-01 | 2.0e-02 | ATF4,Ccl2,CCL4,PTGS2 | NA |
| NPC2 | 8.10e-01 | transporter | NA | -1.50e-01 | 2.0e-02 | BMP2,Ccl2,MAP1LC3B,PTGS2,STAT1 | NA |
| TMBIM6 | 7.00e-02 | other | NA | -1.50e-01 | 2.0e-02 | EDEM1,ERN1,HMOX1,MAP1LC3B | NA |
| plerixafor | NA | chemical drug | NA | -1.50e-01 | 2.0e-02 | CCL17,CXCL6,CXCR4,EDN1,MMP9,SOX2 | NA |
| CALCA | NA | other | NA | -1.50e-01 | 0.0e+00 | ALB,CCL2,CCL4,CD83,CREM,CXCR4,EDN1,FOS,FOSL2,GADD45B,IER3,IKZF3,IL2RB,IL4R,JUNB,KDR,LMO4,MYC,NFIL3,NFKBIA,NRP1,ODC1,Plekha6,PPP1R1B,PRIMA1,PSAT1,RAMP3,RBM14,SDC4,SERPINB1,SERPINE1,TGFA,TNFRSF18,ZEB2 | 517 (18) |
| dimethylnitrosamine | NA | chemical toxicant | NA | -1.50e-01 | 0.0e+00 | BMP3,CDKN1A,CRP,FGFR4,HMOX1,MMP9,Mt1,PRKCH,TIMP1 | 463 (15) |
| pevonedistat | NA | chemical drug | NA | -1.50e-01 | 0.0e+00 | BCL2L1,CCL2,Ccl2,CLDN4,IRS1,SELP,SOX2 | 471 (15) |
| PAX3-FOXO1 | NA | fusion gene/product | NA | -1.60e-01 | 0.0e+00 | ADRA1D,ATP1A1,BTG2,CAP2,CDKN1A,CEP41,CXCR4,DUSP1,ERBB3,FGFR4,FOSL1,HMOX1,IER3,IL4R,IRS1,KCNN3,KDR,MCAM,MEOX1,MEOX2,MYCN,NGFR,Pmaip1,PRRX1,SERPINB1,SHB,SLC7A5 | 458 (16) |
| ZBTB20 | -1.90e-01 | transcription regulator | NA | -1.60e-01 | 1.0e-02 | FASN,IRS1,NEDD9,NFKBIA,PCK1,PDK4,SOCS2,SOCS3 | NA |
| E2F1 | -1.40e-01 | transcription regulator | NA | -1.70e-01 | 0.0e+00 | ABCB1,Acan,AGR2,AR,ARHGAP4,AURKB,BCL2L1,CCNA1,CCNO,CD274,CDKN1A,COL2A1,DDX11,DUSP1,EZH2,FOS,HSD11B2,IRS1,KCNA3,KCNH1,KCNJ11,KDR,LCK,MMP16,MMP9,MYC,MYCN,NFKBIA,NRP1,OGT,PDK4,Pmaip1,PPP1R13B,PPP1R3A,PSAT1,RND3,SELE,SERPINE1,SERPINF2,SOX7,STK17B,TGM1,THBS1,TP53BP2,TP73,TXNRD1,UCK2,ZFP36 | 440 (18) |
| ADIPOQ | -2.00e-01 | other | NA | -1.70e-01 | 0.0e+00 | APOB,BMP2,CCL2,Ccl2,CD163,CDKN1A,CLEC10A,CXCL10,CXCL2,CXCL3,Cyp3a25 (includes others),DLK1,DUSP1,F3,FABP3,FADS6,FASN,FOS,FZD9,HMOX1,HNF4A,IL12B,IL4R,IRS1,Klrk1,MMP9,NFKBIA,PCK1,PPARA,PTGS2,SOAT1,SOCS3,TIMP1,WNT11,WNT5A | 491 (20) |
| ADRB2 | 3.50e-01 | G-protein coupled receptor | NA | -1.70e-01 | 0.0e+00 | ATP1A1,ATP1B1,DIO2,FASN,HK2,IL12B,NRP1,PDGFB,PLXNA1,POU2AF1 | 543 (21) |
| L-carnitine | NA | chemical - endogenous mammalian | NA | -1.70e-01 | 0.0e+00 | ACR,ALB,AQP1,BCL2L1,CDKN1A,EDN1,NRP1 | 585 (17) |
| vorinostat | NA | chemical drug | NA | -1.80e-01 | 0.0e+00 | ACKR4,ADAMTS1,APOB,AR,ATP2B4,BCL2L1,CCL17,CCR3,CD69,CD79B,CD8A,CDKN1A,DUSP1,EDN1,IL12B,IL1A,LGI1,LTA,MMP9,MYC,NFKBIA,OSBPL3,PDGFB,PNPLA3,PTGS2,S100A8,SOCS3,ST8SIA1,TNFSF10,TP73 | 397 (14) |
| tamoxifen | NA | chemical drug | NA | -1.80e-01 | 0.0e+00 | ABCB11,ACOX2,ADORA1,AGR2,AQP1,ATF4,BCL2L1,BMP2,CDKN1A,CEBPD,CLDN4,CXCR4,DLK1,EPHA4,ERBB3,FASN,FOS,G0S2,GJB2,IER3,IRS1,JUNB,KRT7,KRT80,LGALS3,LIF,MAFF,MX1,MYC,NR0B2,PEMT,PPARA,PTGS2,RAMP3,RERG,SCN1B,SELE,SFTPB,SLC7A5,SYT6,TGFA,TRH,ZEB2 | 516 (20) |
| CFTR | 3.00e-02 | ion channel | NA | -1.80e-01 | 0.0e+00 | AQP1,CA4,Ccl2,CUBN,CXCL3,Cyp3a25 (includes others),HSD17B2,NFKBIA,PGLYRP1,POR,PTGS2,S100A8,SOCS3,STAT1,TIMP1 | 476 (18) |
| mir-155 | NA | microRNA | NA | -1.80e-01 | 0.0e+00 | ARG2,CCL2,CD163,CD40LG,CD69,CDKN1A,CXCL10,EDN1,FCER2,GCSAM,HK2,HMOX1,IKBKE,IL12B,IRF4,MX1,PTGS2,SERPINE1,SOCS3,STAT1 | 496 (18) |
| NOS2 | NA | enzyme | NA | -1.90e-01 | 0.0e+00 | ACTC1,AR,AZGP1,BCL2A1,CCL2,Ccl2,CCL4,CD14,CDKN1A,CSF3R,CXCL2,CXCL3,EDN1,FASN,HMOX1,IL12B,IRS1,ISG15,ITIH4,KDR,LCK,LCN2,LPAR1,MMP9,NFKBIA,NRTN,PRF1,PTGS2,S100A8,SERPINH1,TIMP1,TNFSF10 | 440 (17) |
| enterotoxin B | NA | biologic drug | NA | -1.90e-01 | 0.0e+00 | CCL17,CCL2,Ccl2,CCL24,CCL4,CCR6,CD69,CDR2,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,IL12B,IL33,LIF,RSAD2 | 498 (13) |
| HBP1 | 3.20e-01 | transcription regulator | NA | -1.90e-01 | 0.0e+00 | CCL24,CDKN1A,EZH2,MYCN,PDK4,PTGS2 | 459 (21) |
| PTPN6 | -8.00e-02 | phosphatase | NA | -1.90e-01 | 1.0e-02 | BCL2L1,Ccl2,CXCL10,IL12B,ISG15,MMP9,MYC,TBX21,TIMP1 | NA |
| ruxolitinib | NA | chemical drug | NA | -1.90e-01 | 0.0e+00 | BCL2L1,CBS/LOC102724560,CCL2,CD274,CD79A,CD79B,CXCL10,IL6R,LOXL1,MAP1LC3B,MYC,PAX5,PSAT1,PTGS2,RAB20,SOCS2,TNFRSF18 | 343 (16) |
| miR-2682-5p (and other miRNAs w/seed AGGCAGU) | NA | mature microRNA | NA | -1.90e-01 | 0.0e+00 | CREB1,MUC5B,MYC,TIMP3 | NA |
| laminaran | NA | chemical drug | NA | -1.90e-01 | 0.0e+00 | CCL4,CXCL10,EREG,G0S2,IFI44L,IL1A,INHBA,PTGS2,RSAD2,SGPP2,TNFAIP6 | 258 (15) |
| UBE2I | 5.00e-02 | enzyme | NA | -1.90e-01 | 0.0e+00 | ABCB11,ALB,CEBPD,CIDEA,CPT1A,CXCL10,MYC,NR0B2,PDK4,STAT1 | 516 (24) |
| prostaglandin A1 | NA | chemical - endogenous non-mammalian | NA | -1.90e-01 | 0.0e+00 | BCL2L1,CD14,CDKN1A,HMOX1,NFKBIA,PTGS2,SOAT1 | 441 (16) |
| GPS2 | 2.90e-01 | transcription regulator | NA | -2.00e-01 | 0.0e+00 | Ccl2,CCL4,CD14,CDKN1A,CR2,CXCL10,CXCL2,IL12B,Kctd12b,LTA,MYC,NFKBIA,RAB20,TRERF1 | 417 (20) |
| WAKMAR1 | NA | other | NA | -2.00e-01 | 4.0e-02 | DYNLL1,EDN1,FOS,TIMP3,TNFRSF12A | NA |
| resolvin D1 | NA | chemical - endogenous mammalian | NA | -2.00e-01 | 0.0e+00 | CCL2,Ccl2,CXCL2,CXCL3,CXCR4,GBP2,HMOX1,IL33,PTGS2 | 385 (14) |
| tosylphenylalanyl chloromethyl ketone | NA | chemical - protease inhibitor | NA | -2.00e-01 | 0.0e+00 | CCL2,CXCL2,GCLC,GZMB,MYC,PRF1,PTGS2 | 496 (18) |
| SP1 | -7.00e-02 | transcription regulator | NA | -2.10e-01 | 0.0e+00 | ABCB1,ADAMTS1,ADRA1D,AR,ATF3,BMP7,CBS/LOC102724560,CCL2,Ccl2,CD28,CD79B,CDKN1A,CEBPD,CIITA,CIRBP,COL2A1,CR2,CREM,CXCL10,CXCL3,CXCR4,CYP7B1,EREG,F10,F3,FASN,FGFR4,FOS,FOSL1,GNAI2,HAS1,HDC,HK2,HMOX1,HNF4A,HSD11B2,ID4,IFITM5,IL1A,IL21R,IL2RB,IL4R,IRF4,ITGAD,KCNA3,KDR,KRT81,LTB,MAOA,MAOB,MEOX2,MMP9,Mt1,MUC5B,MYC,MYCN,NFKBIA,NGFR,NR5A2,PCK1,PDGFB,PEMT,PLAUR,PRKCB,PROCR,PTGS2,SELL,SERPINE1,SLC11A1,SLC5A1,SLC6A2,SLC7A1,SOAT1,SPN,STAT1,TFPI2,TGFBR3,TGM1,THRB,TIMP1,TIMP3,TNFSF10,TP73,TRH,TRIB1,TXNRD1,UBC,ZEB2 | 526 (22) |
| TGFBR2 | 1.00e-02 | kinase | NA | -2.10e-01 | 0.0e+00 | ADAMTS5,ADGRE1,ADORA2A,ADORA2B,AR,ATF4,BHLHE40,BMP6,Ccl2,CCL4,CD14,CD69,CD83,CDHR1,CDKN1A,CHRNA7,CRISPLD2,CX3CR1,CXCL2,CXCL6,DDIT4,FASN,FGFBP1,FKBP5,GADD45B,GADD45G,GAL,GJB2,GLI1,GNRH1,HDC,HK2,IL1A,IL1R2,IL2RB,JAK3,KCNH1,KDR,Klrk1,KRT7,LAG3,MMP9,NFIL3,NFKBIA,Nrgn,NRP1,ODC1,PDGFB,PIK3C2B,PRSS22,PTGS2,PTPRC,RAMP3,Retnlg,S100A8,SELP,SEMA7A,SERPINE1,SLC16A3,SLC7A5,SOCS3,TBX21,THBS1,TIMP1,TNFRSF12A,TNFRSF18,Tnfsf9,TPBG,TTC22,TXNIP,UPP1,WNT11,ZC3H12A | 522 (18) |
| NR1H3 | -4.50e-01 | ligand-dependent nuclear receptor | NA | -2.10e-01 | 0.0e+00 | ADGRE1,ANGPTL3,APCS,ARG2,ATF3,AURKB,BCL2L1,CCL17,CCL2,Ccl2,CCL24,CCL4,CCR3,CD274,CD5L,CDKN1A,CIDEA,CRP,CX3CR1,CXCL10,CXCL2,DIO2,FASN,G0S2,GBP4,GLI1,IL12B,LAG3,LY86,MERTK,MMP9,Mt1,NFKBIA,NR0B2,NR5A2,PTGS2,THRB,TRH,TRIB1,UBC,ZBP1 | 564 (23) |
| BMP2 | 5.90e-01 | growth factor | NA | -2.10e-01 | 0.0e+00 | Acan,AOC1,BCL2L1,BHLHE40,BMP2,CDKN1A,COL2A1,CRYM,ESRRG,F3,FOS,GADD45B,ID4,INHBA,JUNB,MMP9,MYC,Nes,NFYA,NTRK3,PTGS2,PTX3,SOSTDC1,SOX2,TIMP1,TIMP3,TMEM119,ZBTB16 | 451 (19) |
| nonylphenol | NA | chemical toxicant | NA | -2.10e-01 | 0.0e+00 | APOB,CCL2,CXCL10,EREG,KLHL41,PTGS2,Slco1a1,SLFN12,STK17B | 338 (12) |
| LIPE | -1.80e-01 | enzyme | NA | -2.20e-01 | 0.0e+00 | ADGRE1,ADH1C,ANKRD1,AQP1,ATF3,Ccl2,CDO1,CIB2,CPT1B,EDN1,ELL,FASN,FKBP5,FOS,G0S2,GPR3,MEOX2,PCK1,PDHA1,PDK4,PER1,PHKG1,PLIN5,PPARA,PTGS2,RBP4,SDC4,SOX18 | 475 (24) |
| clodronic acid | NA | chemical drug | NA | -2.20e-01 | 0.0e+00 | ADGRE1,Ccl2,CXCL10,FOS,HMOX1,SELE,SELP,SLC10A1 | 491 (17) |
| temozolomide | NA | chemical drug | NA | -2.20e-01 | 5.0e-02 | BCL2L1,CCL2,CDKN1A,CXCL10,MMP9,NFKBIA | NA |
| IFIH1 | -3.60e-01 | enzyme | NA | -2.20e-01 | 0.0e+00 | CCL2,Ccl2,CCL4,CXCL10,CXCL2,CXCL3,IFI44L,IFIT1,IL12B,ISG15,LCK,NFKBIA,OAS2,PRF1,RND3,RSAD2,USP18 | 270 (18) |
| PTEN | 4.00e-02 | phosphatase | NA | -2.20e-01 | 0.0e+00 | ADAMTS9,AR,ARHGAP10,ATF3,AURKB,BRPF1,BTG2,CA12,CALCRL,Ccl2,CD274,CDKN1A,CTSV,CX3CR1,CXCL10,CXCL2,CXCR4,CYSLTR1,DUSP1,EDN1,ERBB3,ERRFI1,EZH2,F3,FASN,FGFR4,FOS,G0S2,GLIS1,ID4,IFRD1,IL12B,IL4R,ISG15,Kctd12b,KDR,LGALS3,LOXL1,MAPKAPK3,MCAM,MEOX1,MMP9,MYC,NFIL3,NGFR,NR5A2,OGT,OTUB2,P2RY14,PDHA1,PECR,PFKFB3,PPP2R2B,PRKCB,PTGS2,PTPRC,RAMP3,SAT1,SDC4,SELL,SERPINE1,SFTPB,SLC30A10,SOAT1,SOCS3,TGFA,THBS1,TNFRSF14,TNFSF10,TP53BP2,UBA7,ZBTB16,ZEB2 | 465 (20) |
| LAMA5 | 1.10e+00 | other | NA | -2.20e-01 | 0.0e+00 | Ccl2,CCL4,CXCL10,CXCL3,MMP9,STAT1 | 243 (7) |
| ELANE | NA | peptidase | NA | -2.20e-01 | 0.0e+00 | CD14,CEBPD,CSF3R,CXCL2,F2RL1,FOS,GFI1,HMOX1,MMP9 | 339 (15) |
| Ikb | NA | group | NA | -2.20e-01 | 1.0e-02 | BCL2L1,CCL2,CXCL3,PTGS2,TP73 | 248 (15) |
| METRNL | -4.10e-01 | other | NA | -2.20e-01 | 1.0e-02 | Ccl2,CCL4,CXCL2,DIO2 | NA |
| acadesine | NA | chemical drug | NA | -2.20e-01 | 2.0e-02 | CDKN1A,F3,FASN,PTGS2 | NA |
| plumbagin | NA | chemical drug | NA | -2.20e-01 | 4.0e-02 | BCL2A1,BCL2L1,MMP9,PTGS2 | NA |
| PRKACA | -2.10e-01 | kinase | NA | -2.20e-01 | 4.0e-02 | CREM,DIO2,MYC,PCK1,Sik1,SOCS3 | NA |
| VIP | 0.00e+00 | other | NA | -2.30e-01 | 0.0e+00 | CCL2,Ccl2,CCL4,CD274,CEBPD,CREB1,CXCL10,CXCL2,CXCL3,EGR3,FOS,IL12B,IRAK2,MYC,NFKBIA,PRF1,PTGS2,TRH | 393 (17) |
| suramin | NA | chemical drug | NA | -2.30e-01 | 0.0e+00 | CCL2,Ccl2,F3,HMOX1,IL12B,LOX,ODC1,PTGS2 | 416 (20) |
| 15-deoxy-delta-12,14 -PGJ 2 | NA | chemical - endogenous mammalian | NA | -2.40e-01 | 0.0e+00 | ACTC1,ADAMTS4,BCL2L1,CCL2,Ccl2,CDKN1A,CEBPD,CIITA,CPT1B,CXCL10,CXCL2,FOS,GADD45A,GAL,GCLC,HMOX1,IAPP,IFITM2,IL1A,KDR,MAP1LC3B,MMP9,MYC,Nes,NFKBIA,NR5A2,P4HA1,Podxl,PTGS2,SELE,SERPINE1,SFTPB,SOAT1,SOCS3,STAT1,TXNRD1 | 462 (14) |
| mir-17 | NA | microRNA | NA | -2.40e-01 | 4.0e-02 | AR,BCL11B,CAPRIN2,CDKN1A,CPT1A,GCLC,PPARA,SLC28A1,THBS1,TXNIP | NA |
| ADAP1 | -1.50e-01 | other | NA | -2.40e-01 | 0.0e+00 | CD40LG,CD69,FOS,GZMB,LTA,MYC,RGCC | 331 (7) |
| MGLL | -2.00e-01 | enzyme | NA | -2.40e-01 | 0.0e+00 | ADGRE1,Ccl2,CPT1A,FASN,IL1A,PNPLA2,PPARA | 406 (19) |
| BCL11B | -7.00e-01 | transcription regulator | NA | -2.40e-01 | 0.0e+00 | ADORA1,CDKN1A,IL4R,IPMK,LTA,LTB,MAP3K8,NRP1,Pcp4l1,PLXND1,PPP1R1B,TBX21,ZBTB16 | NA |
| SULT1E1 | NA | enzyme | NA | -2.40e-01 | 0.0e+00 | APOB,Ccl2,CIDEA,FASN,LCN2,PTGS2,TNFAIP6 | 504 (22) |
| EFNA1 | 2.60e-01 | other | NA | -2.40e-01 | 1.0e-02 | CD69,EPHA2,FOSL1,KRT75,NEDD4L,PKP1,PLAT,SHB,TGM1 | NA |
| CLEC4A | -4.60e-01 | transmembrane receptor | NA | -2.40e-01 | 4.0e-02 | ADGRE1,BHLHE40,CD83,F10,IL1A,IRF4,LYVE1 | NA |
| salirasib | NA | chemical drug | NA | -2.40e-01 | 1.0e-02 | ATF3,ATF4,BHLHE40,P4HA1,PFKFB3,PLAT,SERPINE1,TGFA | 450 (17) |
| Igm | NA | complex | NA | -2.40e-01 | 0.0e+00 | BCAR3,BCL2A1,BCL2L1,CD22,CD40LG,CD69,CDKN1A,IRF4,MYC,PAX5,TNFRSF14 | 406 (21) |
| EBF2 | -4.80e-01 | transcription regulator | NA | -2.50e-01 | 0.0e+00 | ADAMTS15,CIDEA,DIO2,LGI1,MEOX1,PPARA | NA |
| PAX7 | -2.00e-02 | transcription regulator | NA | -2.50e-01 | 4.0e-02 | CAMK1D,CXCR4,F2RL1,KCNK2,OTUD7A,PKIA,PRRX1,TRIM54 | NA |
| TWIST1 | -1.10e-01 | transcription regulator | NA | -2.50e-01 | 0.0e+00 | Acan,ADAMTS1,AR,C1QTNF1,CBX2,CCL2,Ccl2,CDKN1A,CLDN4,COL2A1,EZH2,FIBIN,FOS,FOSL1,GLI1,LGALS3,MMP9,OSGIN1,PPARA,SLC28A3,SOX2,SPHK1,ST8SIA2,TBX21,TIMP3,TNFRSF21,ZEB2 | 520 (24) |
| ceramide | NA | chemical - endogenous mammalian | NA | -2.50e-01 | 3.0e-02 | FOS,MYC,NAT8B,PTGS2,SFTPB | NA |
| 3M-011 | NA | chemical reagent | NA | -2.50e-01 | 0.0e+00 | BCL2L1,CCL4,CD83,CXCL10,ISG15,MX1,MYC,PTGS2,STAT1 | 460 (20) |
| KLF5 | 2.10e-01 | transcription regulator | NA | -2.50e-01 | 0.0e+00 | BCL2L1,CDKN1A,CEBPD,CPT1B,CSRNP1,CXCL6,CXCR4,DUSP1,FGFBP1,MAFF,MEOX2,MMP9,MYC,PDGFB,PPP1R1B,SOX2,TCF23 | 505 (21) |
| RB1 | -2.90e-01 | transcription regulator | NA | -2.50e-01 | 0.0e+00 | ACTC1,ATF3,ATP1A1,ATP1B1,AURKB,CALCRL,CCNA1,CD274,CD83,CDKN1A,CXCL2,CXCL3,CYSLTR1,DDX11,DIO2,DLK1,DUSP1,EDNRA,EGR3,EHD3,EZH2,F3,FOS,FOSL1,GADD45A,GADD45B,GEM,HUNK,JUNB,KCNK1,KDR,LCK,MYC,NFKBIA,OGT,OSMR,P2RY14,PER1,PPARGC1B,PTX3,RAMP3,SERPINE1,SOX7,TP73,ZEB2,ZFP36 | 491 (18) |
| mir-455 | NA | microRNA | NA | -2.50e-01 | 1.0e-02 | ADAMTS5,HK2,MYC,RUNX1T1 | NA |
| Cyp2c23 | -5.70e-01 | enzyme | NA | -2.50e-01 | 1.0e-02 | ASPA,Ccl2,CX3CR1,MERTK | NA |
| superoxide | NA | chemical - endogenous mammalian | NA | -2.50e-01 | 2.0e-02 | HMOX1,MMP9,PTGS2,TIMP1 | NA |
| Smad2/3 | NA | group | NA | -2.50e-01 | 2.0e-02 | CCL2,CD274,CDKN1A,FSTL3,HMCN1,MMP9,SERPINE1,TBX21,TIMP3 | NA |
| HSPG2 | NA | enzyme | NA | -2.50e-01 | 4.0e-02 | Acan,APOB,COL2A1,CXCR4,GADD45A | NA |
| DSCAM | -3.70e-01 | other | NA | -2.60e-01 | 0.0e+00 | ARHGAP4,CNTNAP1,GADD45G,IRS1,JAK3,KCNA2,KCNJ4,MYC,PAX5,PDGFB,PRKCB,PRKCH,ROR2,SEMA7A,SNCAIP | NA |
| RUNX1 | 1.60e-01 | transcription regulator | NA | -2.60e-01 | 0.0e+00 | ALB,AQP1,ATF3,ATF4,BANK1,BLK,BTG2,CCR6,CD22,CD79A,CDKN1A,EBNA1BP2,EDEM1,EPB42,FOSL2,GPATCH4,Igtp,IL6R,Irgm1,ISG15,ITGA2B,KRT80,LMO4,MAP3K6,MMP8,Mt1,MYC,NFIL3,Oasl2,PLXND1,Pmaip1,Podxl,PRKCB,RGCC,RSAD2,SERPINE1,STAT1,TIMP1,TNFRSF13C,TNFRSF18,TRIB1,UPP1,XCL1,ZBP1,ZBTB16 | 559 (25) |
| indican | NA | chemical - endogenous mammalian | NA | -2.70e-01 | 0.0e+00 | ALB,CCL2,CDKN1A,CXCR4,HMOX1,PTGS2,SELE,SELP,THBS1 | 414 (14) |
| CBL | -4.30e-01 | transcription regulator | NA | -2.70e-01 | 0.0e+00 | CDKN1A,CXCL2,CXCL3,EPHA4,FOS,HMOX1,IL12B,LCK,STAT1 | 460 (19) |
| thioctic acid | NA | chemical drug | NA | -2.70e-01 | 0.0e+00 | CCL2,Ccl2,FOS,HMOX1,MMP9,MYC,PDK4,SELE,TRPV1 | 449 (18) |
| Hsp70 | NA | group | NA | -2.70e-01 | 0.0e+00 | BCL2L1,Ccl2,CD14,CD83,CXCL3,GZMB,IL12B,NFKBIA,SELE,TRIM63 | 328 (16) |
| plicamycin | NA | chemical drug | NA | -2.70e-01 | 0.0e+00 | ADAMTS4,CAMK1G,CCL2,CDKN1A,F3,FASN,GJB2,GNAI2,HMOX1,HSD11B2,KCNA3,KDR,MAOA,MUC5B,NGFR,PLAUR,PPP1R1B,SEMA7A,SERPINE1,SOCS3,TESC,TIMP1,TP73,UBC | 489 (22) |
| sphingosylphosphocholine | NA | chemical - endogenous mammalian | NA | -2.70e-01 | 0.0e+00 | CCL2,Ccl2,FOS,TGM1 | 430 (19) |
| CSF | NA | group | NA | -2.80e-01 | 0.0e+00 | BCL2A1,CCL4,CD22,CD274,FCER2,IL1A,IL1R2,IRAK2,SERPINE1,SOCS3,SPN,TNFAIP6,TNFRSF14 | NA |
| ING4 | 3.00e-02 | transcription regulator | NA | -2.80e-01 | 0.0e+00 | Ccl2,CDKN1A,CXCL10,MYC,NFKBIA | 410 (14) |
| ADCY | NA | group | NA | -2.80e-01 | 0.0e+00 | CCNA1,CDKN1A,CREM,CRYM,FOS,ITGA2B,PER1 | 458 (21) |
| PNN | -2.00e-01 | other | NA | -2.80e-01 | 0.0e+00 | BCL2L1,CDKN1A,MYC,TBRG4,TIMP1 | NA |
| PPP3CB | -1.70e-01 | phosphatase | NA | -2.80e-01 | 0.0e+00 | CDKN1A,GADD45A,IRS1,KLRD1,TRIM63 | 499 (17) |
| cerulenin | NA | chemical drug | NA | -2.80e-01 | 0.0e+00 | Ccl2,CDKN1A,FASN,PPARA,Tnfsf9 | 500 (20) |
| TNFSF9 | NA | cytokine | NA | -2.80e-01 | 1.0e-02 | BCL2L1,CD14,CD8A,KLRD1,PTPRC | 288 (7) |
| HRAS | 1.30e-01 | enzyme | NA | -2.80e-01 | 0.0e+00 | Acan,ADGRE5,ANKRD1,ANXA3,ANXA8/ANXA8L1,AURKB,B3GNT5,BCL2L1,BMP7,BTG2,CALCRL,CBX2,Ccl2,CD274,CD69,CDKN1A,CDON,CEBPD,COL2A1,CPT1A,CRP,CTSV,CXCL10,CXCL2,CXCL3,CXXC5,DLL1,DOK2,DUSP1,DUSP9,ELK3,EREG,FABP3,FASN,FGFBP1,FOS,FOSL1,FOSL2,FSTL3,GADD45G,GJB2,GLI1,HDC,HMOX1,IFITM2,IL1A,IL24,JUNB,LOXL1,LRRC17,MAOB,MAP3K8,MCAM,MMP9,MUC13,MYC,MYCN,NEXN,NFKBIA,NRP1,Oas1h,PCDHGA1,PCK1,PGF,PKP1,PLAUR,PPARGC1B,PRKCB,PTGS2,RASGRP1,SERPINE1,SESN1,SLC30A3,SOAT1,SOCS2,SOCS3,THBS1,TIMP1,TIMP3,TINAGL1,TP73,TRPC3,TRPV1 | 439 (16) |
| Fcer1 | NA | complex | NA | -2.80e-01 | 0.0e+00 | BCL2A1,CCL2,Ccl2,CCL4,CD83,CXCL3,FOS,IL33,INHBA,LIF,SPHK1 | 471 (15) |
| Lymphotoxin | NA | complex | NA | -2.80e-01 | 0.0e+00 | CCL19,CCL2,CXCL10,IL1A,POU2AF1 | 334 (12) |
| Z-551 | NA | chemical reagent | NA | -2.80e-01 | 1.0e-02 | ADGRE1,Ccl2,FASN,PCK1 | 241 (7) |
| H1-2 | NA | other | NA | -2.80e-01 | 1.0e-02 | GADD45A,IER3,LTB,MYC | NA |
| BCL2L11 | 3.80e-01 | other | NA | -2.80e-01 | 4.0e-02 | Ccl2,CD274,CD84,CXCL2 | NA |
| IFNAR1 | 3.00e-02 | transmembrane receptor | NA | -2.80e-01 | 0.0e+00 | ATF3,CCL17,CCL24,CCL4,CD274,CIITA,CMPK2,CXCL10,CXCL2,CXCL3,CXCL6,DLL1,F10,GBP4,HSH2D,IAPP,IFI44,IL12B,IL1A,ISG15,LIF,MYC,OAS2,Oasl2,PLAT,PTGS2,RSAD2,SERPINE1,SOCS3,STAT1,THBS1,TNFSF10,USP18 | 357 (17) |
| TNFRSF8 | -7.80e-01 | transmembrane receptor | NA | -2.90e-01 | 0.0e+00 | CCL4,CDKN1A,CXCR4,GBP2,GCLC,GZMB,IRF4,JUNB,MYC,ODC1,PRF1,TNFRSF8,TNFSF10 | 435 (18) |
| ICOS | -1.00e-01 | transmembrane receptor | NA | -2.90e-01 | 1.0e-02 | Ccl2,CCR3,CD40LG,CD69,CXCR4,IL1A,IL2RB,TBX21 | 444 (18) |
| resiquimod | NA | chemical drug | NA | -2.90e-01 | 0.0e+00 | ATF3,ATF4,BCL2A1,BMP6,C3AR1,CCL19,CCL2,Ccl2,CCL24,CCL4,CD180,CD22,CD27,CD83,CIITA,CXCL10,CXCL2,CXCL3,DLL1,FCER2,FCN1,FOS,IER3,IFI44L,IFIT1,IL12B,IL1A,IL21R,IL33,INHBA,IRAK2,IRF4,ISG15,JAK3,LAT2,LAX1,LGALS3,LIF,LTA,MS4A1,MX1,NFKBIA,OAS2,PAX5,PLAT,POU2F2,PRKCB,PTGIR,PTGS2,PTPRC,PTX3,RGCC,SEMA7A,SFPQ,SOCS3,STAP1,STAT1,TBX21,TLR10,TNFRSF13C,TNFRSF8,TNFSF10,Tnfsf9,TRPM2,ZC3H12A | 434 (18) |
| TNIP1 | 1.10e-01 | other | NA | -2.90e-01 | 3.0e-02 | CXCL2,CXCL3,ISG15,LCN2,MMP8,S100A8 | NA |
| glutamine | NA | chemical - endogenous mammalian | NA | -3.00e-01 | 0.0e+00 | ACTC1,ATF4,CD274,CDKN1A,CPT1B,DDIT4,DUSP1,FOS,GADD45A,JUNB,LIF,LTA,MYC,NFKBIA,NGFR,PCK1,PDGFB,PTGS2,SOX2 | 517 (22) |
| HMGA1 | 3.00e-01 | transcription regulator | NA | -3.00e-01 | 3.0e-02 | ARL4A,CD19,CTSH,FOS,FOSL2,IER3,IPMK,JUNB,KCNJ11,LTA,MMP9,MYC,PTGS2,SDC4,SERPINH1,SOX2,TRH | NA |
| ZEB1 | -2.40e-01 | transcription regulator | NA | -3.00e-01 | 0.0e+00 | ANKRD1,CD163,EDN1,HK2,LOX,MMP9,NRP1,PTGS2,RASSF1,SERPINE1,SFTPB,THBS1,TP73,XDH | 502 (18) |
| TEAD2 | -4.10e-01 | transcription regulator | NA | -3.00e-01 | 0.0e+00 | BBOX1,EDN1,EDNRA,FGFR4,FIBIN,FJX1,GPR37,KAZN,LOXL1,PTPRO,THBS1 | NA |
| STIM1 | 2.60e-01 | ion channel | NA | -3.00e-01 | 0.0e+00 | ATF4,BCL2L1,CAMK1D,CDKN1A,FOSL1,GCLC,HMOX1,JUNB,KDR,KLF15,MYC,SMO | 519 (19) |
| apigenin | NA | chemical - endogenous non-mammalian | NA | -3.00e-01 | 0.0e+00 | ABCB1,AR,BCL2L1,CCL2,Ccl2,CCL4,CDKN1A,CREM,CXCL3,FOS,GCLC,HMOX1,LTA,MMP8,MMP9,PTGS2,SELE | 399 (14) |
| glutathione | NA | chemical - endogenous mammalian | NA | -3.00e-01 | 0.0e+00 | ABCB1,ALB,ATF3,BCL2L1,Ccl2,CD274,CDKN1A,GCLC,GFPT2,HMOX1,MYC,PTGS2,SERPINE1,TNFRSF8 | 404 (14) |
| adavosertib | NA | chemical drug | NA | -3.00e-01 | 0.0e+00 | BLK,CD83,CX3CR1,CXCL10,IFIT1,IL1A,IL4R,IRAK2,ISG15,JAK3,MERTK,MX1,PLAUR,SLC11A1,STAT1,TBX21,THBS1,TLR5,TNFRSF18 | 491 (19) |
| Tcf7 | -3.00e-01 | transcription regulator | NA | -3.10e-01 | 0.0e+00 | ACSBG1,AR,ARHGAP20,BCL11B,BLK,CCL4,CCR6,CCR9,CD101,CD19,CD27,CD69,CD79A,CD79B,CD83,CDKN1A,CEBPD,CX3CR1,DNASE1L3,EGR3,ELK3,EZH2,FOSL1,G0S2,GEM,GZMA,H2-Eb2,IKZF3,IL21R,IL2RB,IL4R,IRF4,Klrb1f,LAG3,LONRF1,MCAM,MMP9,NR5A2,NRN1,NUPR1,OSBPL3,PDGFB,Pmaip1,PRF1,PTPRO,SELL,SGMS1,SOAT1,SOCS2,SOCS3,SPATC1,SPECC1,SRPK3,STAT1,SYTL2,TBX21,TNFRSF13C,TNFRSF19,ZC3H12D | 333 (7) |
| ADM | 3.90e-01 | other | NA | -3.10e-01 | 4.0e-02 | CCL2,Ccl2,CXCL2,EDN1,FOS,PTGS2,RAMP3 | NA |
| FZD9 | 1.68e+00 | G-protein coupled receptor | NA | -3.10e-01 | 0.0e+00 | Ccl2,CXCL10,CXCL6,IFI44,ISG15,Oasl2,STAT1 | 370 (11) |
| GATA2 | 5.30e-01 | transcription regulator | NA | -3.20e-01 | 0.0e+00 | ADGRE5,AK1,AR,ARNT2,AZGP1,BPIFB1,C9,CCL2,Ccl2,CCR3,CD69,CDKN1A,CXCL10,CXCL2,CXCR4,DIO2,DLK1,DLL1,EDN1,EDNRA,FCN1,GABRP,GBP2,GCSAM,GFI1,GRTP1,GZMA,HDC,HMOX1,HNF4A,IL2RB,IL4R,ITGA2B,KDR,KHDRBS3,LAX1,LCN2,MAOB,MYC,NFIL3,Pcp4l1,Retnlg,RGS18,S100A8,SELP,SOX18,SOX2,SPN,SPNS3,TFR2,TGFBR3,THBS1,TREM3,TRPM2,UBXN10 | 491 (22) |
| ABCA1 | 2.40e-01 | transporter | NA | -3.20e-01 | 0.0e+00 | APOB,Ccl2,CPT1A,CXCL3,FASN,IL12B,MMP9,PTGS2,SELP | 471 (20) |
| TNPO3 | 1.40e-01 | other | NA | -3.30e-01 | 0.0e+00 | CCR9,CD19,CD28,CD79A,CD79B,CD8A,GZMA,PAX5,POU2AF1 | NA |
| imiquimod | NA | chemical drug | NA | -3.40e-01 | 0.0e+00 | BTG2,Ccl2,CCL4,CCR10,CD274,CXCL10,CXCL2,CXCL3,CXCL6,FOS,FOSL1,GLI1,HMOX1,IL12B,IL1A,IL6R,ISG15,JUNB,LCN2,MX1,MYC,POU2AF1,PTGS2,RNF213,RSAD2,S100A8,SELL,SOCS3,STAT1,TNFSF10,UBC | 476 (17) |
| hydrochloric acid | NA | chemical - endogenous mammalian | NA | -3.40e-01 | 0.0e+00 | CCL2,Ccl2,CCL4,CXCL2,CXCL3,FOS,HSH2D,SELE | 464 (16) |
| IL17a dimer | NA | complex | NA | -3.40e-01 | 3.0e-02 | CCL2,CCL4,IL1A,LCN2 | NA |
| L-triiodothyronine | NA | chemical - endogenous mammalian | NA | -3.40e-01 | 0.0e+00 | AADAT,ACTC1,ADAMTS5,ALB,ANGPTL3,APOB,AR,ATP1A1,ATP1B1,ATP8B4,BCAR3,BCL2L1,BTG2,CDC42EP4,CDKN1A,CIDEA,COQ10B,CPT1A,CPT1B,CTSH,CYP26B1,D1Pas1,DAB2IP,DIO1,DIO2,DLK1,DUSP1,ECE1,EDN1,EDN3,F3,FASN,FGA,FKBP10,FNDC5,FOS,GBP4,GHRHR,GNAI2,H2-T22,H6PD,ITGA7,KCNK1,KRT17,LCN2,LGALS3,MMP9,MYBPH,MYC,NR5A2,Nrgn,ODC1,PCK1,PDK4,PDLIM3,PER1,PHOSPHO1,Pln,Pmaip1,PNPLA3,POR,PPARA,PPARGC1B,PRR16,PSAT1,PTGS2,RASGRP1,RBM20,RGN,RGS16,RYR2,SBK1,SEMA7A,SERPINE1,SLC22A7,SLCO1C1,SNURF,STK17B,TBC1D30,TET1,THRB,TRH,WIPF3,WNT7A | 502 (23) |
| TFAP4 | 0.00e+00 | transcription regulator | NA | -3.40e-01 | 2.0e-02 | BCL2L1,CDKN1A,CLDN4,FOS,IL12B,LIF,MLF1 | NA |
| N-[(2Z)-3-(4,5-dihydro-1,3-thiazol-2-yl)-1,3-thiazolidin-2-yl idene]-5H dibenzo[a,d][7]annulen-5-amine | NA | chemical reagent | NA | -3.50e-01 | 0.0e+00 | BCAR3,CREM,ESRRG,FASN,FOS,HSD17B2,MMP9,MYC,NR0B2,RERG,SERPINE1,TNFSF10,UBC,XDH | 326 (10) |
| PGF | 1.78e+00 | growth factor | NA | -3.50e-01 | 0.0e+00 | ATF3,CCL2,CCL28,CCL4,CXCR4,EDN1,EREG,MMP9,SERPINE1 | 442 (18) |
| heparin | NA | chemical - endogenous mammalian | NA | -3.50e-01 | 1.0e-02 | APOB,CD83,DUSP1,F3,FOS,MMP9,PLAT,PROCR,SELP,TNFAIP6 | NA |
| SB203580 | NA | chemical drug | NA | -3.50e-01 | 0.0e+00 | Acan,ADAMTS4,ADAMTS9,ANXA3,AQP1,AR,ATF3,BMP2,C3AR1,CCL17,CCL2,Ccl2,CCL4,CD274,CD28,CD69,CD83,CDKN1A,CEBPD,CIITA,CLDN5,CREB1,CRP,CTSH,CX3CR1,CXCL10,CXCL2,CXCL3,CYP26B1,DUSP1,EREG,EXOC3L4,F3,FABP3,FCER2,FOS,GADD45A,GBP2,GBP4,GZMB,HAS1,HAS3,HEPACAM,HK2,HMOX1,HSD11B2,IER3,IFIT1,IL12B,IL1A,ISG15,JUNB,KDR,MAP2K6,MMP8,MMP9,MUC5B,MX1,MYC,MYOCD,NFKBIA,NKD2,P4HA1,PCK1,PDGFB,PLA1A,PLAT,PLAUR,PPARA,PPARGC1B,PTGS2,RBM3,RFLNA/ZNF664-RFLNA,S1PR5,SELE,SELP,SERPINE1,Slpi/Slpil2,SNAP23,SOCS3,SOX7,STAT1,STK17B,TFPI2,TGM1,THBS1,TIMP1,TIMP3,TNFAIP6,TNFSF10,TNFSF8,TRPA1,TRPV1,VGLL3,XDH | 476 (15) |
| JAK | NA | group | NA | -3.60e-01 | 0.0e+00 | BCL2L1,CCL2,CD83,CXCL10,IFIT1,IL12B,IL33,ISG15,MMP9,PTGS2,RSAD2,SOCS2,SOCS3,STAT1,TRIM63 | 371 (20) |
| BAPTA-AM | NA | chemical reagent | NA | -3.60e-01 | 0.0e+00 | ATF3,CCL2,CDKN1A,CXCL10,CXCL2,FOS,MMP16,PTGS2,S100A8,SELE,SOCS2,SOCS3,TRPC3 | 423 (18) |
| PITX2 | -2.80e-01 | transcription regulator | NA | -3.60e-01 | 0.0e+00 | ADH1C,ATP1A1,ATP1B1,CCNA1,CYP26B1,CYP2S1,DACH1,FOXC1,FZD9,GADD45A,HCN4,KCNJ11,KCNK2,MYC,NGFR,PPP1R1B,SHOX2,SOX2,TBX6,TNFSF8,WNT5A,ZEB2 | 355 (11) |
| GAPDH | -3.00e-01 | enzyme | NA | -3.70e-01 | 0.0e+00 | BCL2L1,CCL2,CCL4,DUSP1,GEM,IFITM2,OAS2,SLC38A2,STAT1,TXNIP | 434 (19) |
| grape seed extract | NA | chemical drug | NA | -3.70e-01 | 3.0e-02 | BCL2L1,CDKN1A,CREB1,MYC,PTGS2 | NA |
| IL32 | NA | cytokine | NA | -3.70e-01 | 0.0e+00 | BCL2L1,CCL2,CCL4,CXCL3,IL12B,IL1A,MMP9,MX1,PTGS2 | 313 (15) |
| ERG | 4.00e-02 | transcription regulator | NA | -3.80e-01 | 4.0e-02 | AR,ARHGAP20,ARHGAP4,CAMK1D,CXCR4,EZH2,FKBP5,HPCAL1,LAMA5,MMP9,MYCN,NFIL3,PLAT,PLAUR,RASSF1,TDRD5,THBS1,WNT11,ZBTB16 | NA |
| RRAS2 | 1.00e-02 | enzyme | NA | -3.80e-01 | 0.0e+00 | ACER2,ADAMTS5,BVES,CD14,CD40LG,CDH6,EGR3,FERMT1,FOSL1,GFPT2,HLA-DOB,IER3,IFI44L,IFITM2,IL4R,ITGA7,METTL7B,NEXN,NRP1,PGF,PROCR,RGS16,RSAD2,SCN1B,SELE,SERPINE1,TRIM14,USP18 | 227 (7) |
| soloxolone methyl | NA | chemical reagent | NA | -3.80e-01 | 0.0e+00 | Ccl2,IFI44,MMP8,RSAD2,SERPINE1,SOCS3,TIMP1 | NA |
| STK40 | 5.00e-02 | kinase | NA | -3.80e-01 | 0.0e+00 | ABCB1,CCL2,Ccl2,CCL4,DLK1,MEOX1,OSR1,PTGS2,SFTPB,ST8SIA6,TBX6,TLR5,WNT11,WNT5A,WNT7A | 254 (9) |
| MALT1 | 5.80e-01 | peptidase | NA | -3.80e-01 | 0.0e+00 | CD83,CXCL2,CXCL3,IRF4,LCN2,MMP9,S100A8 | 390 (16) |
| SH42 | NA | chemical reagent | NA | -3.80e-01 | 0.0e+00 | FADS6,GAB2,HSH2D,MERTK,PRKCB,RPS6KA6,STAT1 | NA |
| NVP-TAE684 | NA | chemical drug | NA | -3.80e-01 | 0.0e+00 | CD274,ERBB3,FOSL2,JUNB,MYC,SERPINE1,TNFRSF8 | 429 (20) |
| FYN | 3.90e-01 | kinase | NA | -3.80e-01 | 0.0e+00 | Ccl2,CCL4,CXCL10,DUSP1,FOS,IRF4,PTGS2,SOCS3 | 405 (17) |
| beta-carotene | NA | chemical - endogenous mammalian | NA | -3.80e-01 | 1.0e-02 | ALB,ARRDC3,CCR9,IL1A,NPR3,PTGS2,RBP4 | NA |
| NUP98-DDX10 | NA | fusion gene/product | NA | -3.80e-01 | 1.0e-02 | C3AR1,GADD45B,Meis1,MYC,MYCN,PTGS2,RAD18 | NA |
| CXCL10 | 6.60e-01 | cytokine | NA | -3.80e-01 | 0.0e+00 | Ccl2,CD274,CXCL10,FOS,IL1A,LAG3,MMP9 | 486 (21) |
| ABCG1 | 1.50e-01 | transporter | NA | -3.80e-01 | 1.0e-02 | Ccl2,CCL4,CXCL3,CYP7B1,FASN,IL12B,MYC,SOX2 | 456 (20) |
| PAX3 | 8.00e-02 | transcription regulator | NA | -3.90e-01 | 0.0e+00 | ATP2B4,BCL2L1,CDKN1A,CLDN5,CPN2,CXCR4,F2RL1,F3,FUBP1,G0S2,HPX,ID4,IFITM2,IL6R,IRS1,LRRC17,MCAM,MCC,MEOX1,MGP,MMP9,NEDD9,NPC2,PGF,PKIA,PTGER3,SFN,SIX1,ST8SIA2,TCN2,TFPI2,TIMP3,TRIM14 | 447 (13) |
| TSC1 | 1.80e-01 | other | NA | -3.90e-01 | 2.0e-02 | ATP6V0A4,CTSV,FASN,GLUL,HMOX1,IL12B,IRS1,MAP2K6,NPC2,PPP1R1B,STAT1 | NA |
| CBS/LOC102724560 | 7.70e-01 | enzyme | NA | -3.90e-01 | 0.0e+00 | APOB,CCL2,CDO1,CLDN5,LOX | 396 (7) |
| HSPB8 | 2.60e-01 | kinase | NA | -3.90e-01 | 2.0e-02 | CCL2,CPT1A,LPIN1,MAP1LC3B,PPARA | NA |
| palbociclib | NA | chemical drug | NA | -3.90e-01 | 0.0e+00 | ATF3,CD274,CD83,CDKN1A,CXCL10,DUSP1,EGR3,F9,GADD45A,GADD45B,GBP4,IFI44,IFIT1,ISG15,JUNB,LIF,MMP9,MX1,PER1,PRKCB,SOCS3,USP18,ZFP36 | 418 (20) |
| DDIT3 | 2.40e-01 | transcription regulator | NA | -4.00e-01 | 0.0e+00 | ANKRD1,ATF3,ATF4,CEBPD,H6PD,HMOX1,IL12B,IRAK2,LCN2,LOX,MLF1,NFIL3,PER1,PLAT,SELE,SOX2,SPOCK1,TXNIP | 538 (18) |
| MAP2K1 | 1.40e-01 | kinase | NA | -4.00e-01 | 0.0e+00 | ABCB1,ACSBG1,ANKRD1,ATF3,BCL2A1,BCL2L1,BMP2,CCL2,CCL4,CD274,CDKN1A,CRP,CXCL3,CYP46A1,DUSP1,ERRFI1,F3,FASN,FOS,FOSL1,GADD45B,HDC,IER3,IL1A,IL4R,IRS1,ITGA2B,LGALS3,MAOB,MMP9,MUC5B,MYC,MYCN,NFKBIA,PLAUR,PTGS2,SEMA7A,TFPI2,THBS1,TNFRSF12A,TNFSF10,TRIB1,UBC | 449 (17) |
| PTGS1 | 3.40e-01 | enzyme | NA | -4.00e-01 | 1.0e-02 | ATF3,Ccl2,EDN1,GEM,MMP9,PTGER3,PTGS2 | NA |
| MIR101 | NA | group | NA | -4.00e-01 | 0.0e+00 | CLDN5,DUSP1,EZH2,OGT,PTGS2 | NA |
| FOXP3 | -1.80e-01 | transcription regulator | NA | -4.00e-01 | 0.0e+00 | CCR3,CD101,CD40LG,CD69,CDKN1A,CXCR4,CYSLTR1,EZH2,FOS,FOSL2,GBP2,GBP4,GZMA,IL2RB,IL6R,IRF4,LAG3,LGALS3,LRRC32,LTA,MMP9,NFIL3,NRN1,NRP1,NTRK3,P2RY10,PGLYRP1,Pmaip1,PRF1,RBM14,SDC4,SELL,SLC16A3,SOCS2,TBX21,TLR10,TNFRSF18,TNFSF8,XCL1,ZEB2 | 466 (18) |
| HDAC3 | 0.00e+00 | transcription regulator | NA | -4.10e-01 | 0.0e+00 | Acan,BMP2,CDKN1A,CXCL10,CXCL2,DIO1,FASN,FCER2,FOS,HK2,HMOX1,IL12B,MMP9,MYC,NFKBIA,PTGS2,SERPINE1,USP18 | 417 (14) |
| poly dA-dT | NA | chemical reagent | NA | -4.10e-01 | 0.0e+00 | CXCL10,ISG15,NFKBIA,RSAD2,SELE,STAT1,ZBP1 | 475 (21) |
| GSK3B | -1.50e-01 | kinase | NA | -4.10e-01 | 0.0e+00 | AR,BCL2A1,BCL2L1,CCL2,Ccl2,CDKN1A,CLDN5,CXCL6,DLL1,EZH2,FOS,GFI1,GFPT2,GLI1,IL12B,ISG15,KDR,LCN2,MMP9,MYC,PTGS2,SELP,SERPINE1,TET1,TNFSF10 | 403 (15) |
| pitavastatin | NA | chemical drug | NA | -4.10e-01 | 3.0e-02 | Ccl2,FOS,JUNB,MMP9,PTGS2 | NA |
| FLCN | 4.00e-02 | other | NA | -4.20e-01 | 0.0e+00 | ABCB1,ABCC2,ADAMTS1,ANXA3,BHLHE40,CHRNA7,CIDEA,COL2A1,CXCR4,EPHA2,GULP1,HK2,HMOX1,NPC2,PHOSPHO1,PLXND1,PPARGC1B,SERPINE1,ZC3H12A | 385 (12) |
| SAA | NA | group | NA | -4.20e-01 | 0.0e+00 | CCL17,CCL2,Ccl2,F3,IL12B,IL33,IRF4,PTGS2 | 368 (15) |
| Am 580 | NA | chemical reagent | NA | -4.30e-01 | 0.0e+00 | CPT1A,CYP26B1,DUSP1,F3,FASN,MYCN,PLAT,PPARA,TIMP1 | 525 (24) |
| MEF2D | 3.40e-01 | transcription regulator | NA | -4.30e-01 | 1.0e-02 | BLK,FOS,GCLC,HMOX1,IRF4,JUNB,MEOX2,MYOCD,PPARA,ZFP36 | NA |
| tofacitinib | NA | chemical drug | NA | -4.30e-01 | 0.0e+00 | CBLB,CCL2,CXCL10,DNASE1L3,HK2,IL12B,ISG15,JAK3,MYC,SOCS2,SOCS3 | 423 (20) |
| EGR2 | -2.00e-01 | transcription regulator | NA | -4.30e-01 | 0.0e+00 | ATF3,BHLHE40,CBLB,CCR9,CDH6,CDKN1A,CHRNA7,CHST7,DIO2,DOK2,EPHA4,FCER2,FOS,FRAT2,GJB1,ID4,IL1A,IL1R2,IL21R,IL6R,KDR,LAG3,MYC,NFIL3,NGFR,PDE4A,PLAUR,PLCL1,PPL,RAB20,RAB37,SOCS3,SOX2,SPECC1,TBX21,TGFBR3,TNFRSF8,TNFSF10,XKRX,ZBTB16,ZEB2,ZNF519 | 543 (22) |
| fluoxetine | NA | chemical drug | NA | -4.30e-01 | 4.0e-02 | BCL2L1,FGFBP1,FOS,KCNA5,KCNK2,MYC,PDE4A,PPP1R1B,TRH | NA |
| poly rI:rC-RNA | NA | biologic drug | NA | -4.30e-01 | 0.0e+00 | ARG2,ARID5A,ATF3,ATF4,BMP2,BTLA,CCL17,CCL2,Ccl2,CCL4,CCR3,CD14,CD163,CD274,CD40LG,CD69,CD83,CDKN1A,CEBPD,CIITA,Clec2e/Clec2h,CMPK2,CRP,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DDIT4,DIO1,DIO2,DLK1,DLL1,DUSP1,EREG,FCN1,FOS,FOSL1,GADD45B,GBP2,GBP4,GBP5,GCSAM,GEM,GLI1,H2-T24,HAS1,IFI44,IFI44L,IFIT1,IGSF9B,Igtp,IKBKE,IL12B,IL1A,IL33,IL4R,INHBA,IRAK2,Irgm1,ISG15,JUNB,Klrk1,KYNU,LIF,LIMK1,LTA,LTB,MAFF,MERTK,MMP9,MX1,Mx2,MYC,NEDD9,NFIL3,NFKBIA,OAS2,Oasl2,ODC1,OXA1L,PFKFB3,PLAUR,POU2AF1,PTGS2,RSAD2,S100A8,SAT1,SDC4,SELE,SERPINE1,SIDT1,SOCS3,SOX2,SPSB1,SSBP3,STAT1,STON2,TFPI2,TGFA,THBS1,TIMP1,TLR5,TNFAIP6,TNFRSF21,TNFSF10,Tnfsf9,TRIM14,TRPV1,UBA7,USP18,WNT5A,XCR1,XPO1,ZBP1,ZC3H12A,ZFP36 | 525 (17) |
| salicylic acid | NA | chemical drug | NA | -4.40e-01 | 0.0e+00 | BCL2L1,CCL4,CXCL10,F3,FCER2,FKBP5,IL1A,MMP9,PTGS2,SELP,TNFSF10,XCL1 | 375 (17) |
| Rxr | NA | group | NA | -4.40e-01 | 0.0e+00 | ABCB11,ABCC2,AQP3,BCL11B,BMP7,BTG2,CDKN1A,CPT1A,CPT1B,DIO1,DLK1,GADD45A,IL1A,MGP,MYC,NR0B2,NR5A2,PCK1,PDGFB,PDK4,POR,PTGS2,PTPRO,SLC10A1 | 469 (22) |
| NCOA1 | -1.20e-01 | transcription regulator | NA | -4.40e-01 | 0.0e+00 | ABCB11,BTG2,CDKN1A,DIO1,ERBB3,FOS,FRAT2,GJB2,IL12B,JUNB,KDR,LPIN1,MYC,NFKBIA,NOCT,NR0B2,PCK1,PLCD1,SERPINE1,SFTPB | 527 (25) |
| PRKCZ | -2.80e-01 | kinase | NA | -4.40e-01 | 5.0e-02 | HMOX1,MMP9,MYC,NFKBIA,PSAT1 | NA |
| DNMT1 | 0.00e+00 | enzyme | NA | -4.40e-01 | 2.0e-02 | CDKN1A,CIDEA,EZH2,GATA5,Mt1,MYC,PRF1,PTGS2,RASSF1,TIMP3,WNT5A | NA |
| SIX1 | -1.42e+00 | transcription regulator | NA | -4.40e-01 | 1.0e-02 | ABLIM1,ACTC1,AK1,BHLHE40,CCNA1,DACH1,ENC1,ERBB3,FABP3,ITGA7,KCNH1,MYBPH,PKIA | NA |
| DOCK8 | -5.00e-01 | other | NA | -4.50e-01 | 0.0e+00 | ARID5A,CCL4,CMPK2,CXCL10,EDN1,HDC,IL12B,INHBA,ISG15,LMO4,LTA,MERTK,Mx2,PLA1A,PLAT,PTGS2,RILPL1,RSAD2,STAT1,TNFSF8 | NA |
| SASH1 | 1.70e-01 | other | NA | -4.50e-01 | 0.0e+00 | ARID5A,CCL4,CMPK2,CXCL10,EDN1,HDC,IL12B,INHBA,ISG15,LMO4,LTA,MERTK,Mx2,PLA1A,PLAT,PTGS2,RILPL1,RSAD2,STAT1,TNFSF8 | 281 (10) |
| T-5224 | NA | chemical reagent | NA | -4.50e-01 | 0.0e+00 | ADAMTS1,ADAMTS9,ARHGAP20,ATF4,CRISPLD2,EREG,F3,FKBP5,GADD45B,INHBA,LRRN3,MRO,PFKFB3,PTGS2,PTX3,SMARCA1,SOCS3,TFPI2,TNFRSF21,TRIB1 | NA |
| CpG oligonucleotide | NA | chemical drug | NA | -4.50e-01 | 0.0e+00 | BCL2A1,Ccl2,CCL4,CD14,CD274,CD40LG,CD83,CXCL10,CXCL2,DUSP1,IL12B,IL33,ISG15,MYC,OAS2,Oasl2,POU2AF1,PTGS2,SERPINE1,SLC7A5,THBS1,TNFSF10,ZBP1 | 272 (17) |
| gamma-linolenic acid | NA | chemical - endogenous mammalian | NA | -4.50e-01 | 0.0e+00 | CCL2,FASN,HMOX1,PLIN5,PTGS2 | 373 (12) |
| valine | NA | chemical - endogenous mammalian | NA | -4.50e-01 | 0.0e+00 | Acot1,ALB,CD83,CDKN1A,PPARA | NA |
| PIAS4 | -1.00e-02 | transcription regulator | NA | -4.50e-01 | 0.0e+00 | ALB,CXCL2,IL12B,PDK4,SERPINE1 | 433 (21) |
| 1’-acetoxychavicol acetate | NA | chemical reagent | NA | -4.50e-01 | 0.0e+00 | BCL2A1,BCL2L1,MMP9,MYC,PTGS2 | 393 (18) |
| bevacizumab | NA | biologic drug | NA | -4.50e-01 | 0.0e+00 | CXCL6,CXCR4,KDR,NRP1,PGF | 326 (12) |
| HRG | NA | other | NA | -4.50e-01 | 0.0e+00 | CCL24,CD83,CXCR4,TIMP1,TIMP3 | 430 (9) |
| PF-562271 | NA | chemical drug | NA | -4.50e-01 | 0.0e+00 | Ccl2,CCL4,CXCL10,GBP2,IL1A | 379 (13) |
| NT5E | -1.10e-01 | phosphatase | NA | -4.50e-01 | 1.0e-02 | Ccl2,CD69,KDR,SERPINE1,TIMP1 | 410 (16) |
| chelerythrine | NA | chemical drug | NA | -4.50e-01 | 1.0e-02 | Acan,Ccl2,CXCL3,NFKBIA,SELE | 441 (16) |
| choline | NA | chemical - endogenous mammalian | NA | -4.50e-01 | 1.0e-02 | CDKN1A,ERRFI1,HMOX1,PEMT,PTGS2,RBP4 | NA |
| Wnt | NA | group | NA | -4.50e-01 | 1.0e-02 | ADAMTS5,CDH15,GLI1,KDR,MMP9,MYC,SIX1 | NA |
| estradiol-17beta-benzoate | NA | chemical reagent | NA | -4.50e-01 | 1.0e-02 | COL2A1,FOSL2,GLUL,HS3ST5,ICAM5,JAK3,MGP,MYC,MYCN,NR5A2,PCDH20,Pcp4l1,PROCR,RAB37,RPS6KA6,SLC13A4,SOSTDC1,SPSB1,SPTBN4,SYT6 | NA |
| miR-203a-3p (and other miRNAs w/seed UGAAAUG) | NA | mature microRNA | NA | -4.50e-01 | 1.0e-02 | ABL1,CREB1,EZH2,F2RL1,SOCS3 | NA |
| KIN001-043 | NA | chemical drug | NA | -4.50e-01 | 2.0e-02 | COL2A1,MYC,Nes,NR5A2,SOX2,TNS4 | NA |
| SLC22A5 | 5.00e-02 | transporter | NA | -4.50e-01 | 2.0e-02 | BMP6,CDKN1A,ITGB7,JUNB,STAT1 | NA |
| cicaprost | NA | chemical drug | NA | -4.50e-01 | 4.0e-02 | ADAMTS1,ADAMTS5,CXCR4,HAS1,MMP9 | NA |
| NCSTN | 1.60e-01 | peptidase | NA | -4.50e-01 | 4.0e-02 | CD14,CD84,CEBPD,ITGA2B,TREM3 | NA |
| CP-55940 | NA | chemical reagent | NA | -4.50e-01 | 0.0e+00 | AR,BCL2L1,BTG2,CCL2,CCL4,GADD45A,GRK5,JUNB,MYC,NFKBIA,PRKCB,UBC | 358 (14) |
| PRMT1 | -1.00e-01 | enzyme | NA | -4.50e-01 | 0.0e+00 | APCDD1,AR,ARG2,Ccl2,CD274,CIDEA,CPT1B,CXCL3,FTL,GCLC,ITGA2B,LOXL1,Meis1,PDK4,PPARA,SERPINE1,ZEB2 | 535 (25) |
| CNR1 | 2.40e-01 | G-protein coupled receptor | NA | -4.60e-01 | 0.0e+00 | ADORA1,APCDD1,BCL11B,BMP2,BMP7,Ccl2,CREB3L3,CXCL10,CYP7B1,DLL1,ERRFI1,FASN,FOS,HEYL,PAX5,PTGS2,SIX1,TIMP1 | 476 (20) |
| apicidin | NA | chemical - endogenous non-mammalian | NA | -4.60e-01 | 3.0e-02 | CCR3,CDKN1A,H6PD,ITGB7 | NA |
| mir-26 | 7.00e-02 | microRNA | NA | -4.60e-01 | 2.0e-02 | CHORDC1,CXCL3,EZH2,PFKFB3,PTGS2 | NA |
| pregnenolone carbonitrile | NA | chemical drug | NA | -4.60e-01 | 0.0e+00 | ABCB1,ABCB11,ABCC2,Ccl2,CPT1A,Slco1a1,SLCO1C1,SPHK1,TNFRSF14 | 341 (13) |
| CX3CL1 | 2.80e-01 | cytokine | NA | -4.60e-01 | 0.0e+00 | ADAMTS1,APCDD1,ASPA,ATF4,BCL2L1,BMP6,BMP7,CCL2,CD200R1L,CD27,CD5L,CDCA7,CDHR1,CX3CR1,ERBB3,ERN1,HEYL,HMOX1,IL1A,LMO4,LPAR1,Meis1,MMP9,SELP,SPHK1,SPON2,SYT1,TIMP1 | 466 (21) |
| STAT1 | -6.90e-01 | transcription regulator | NA | -4.70e-01 | 0.0e+00 | BCL2A1,BCL2L1,CCL19,CCL2,Ccl2,CCL4,CCR6,CD14,CD274,CDKN1A,CEBPD,CIITA,CMPK2,CREM,CSF3R,CX3CR1,CXCL10,CXCL2,CXCL3,EDN1,FGA,FOS,GBP2,GBP4,GBP5,HAPLN3,IFI44,IFI44L,IFIT1,IFITM2,Igtp,IL12B,IL1A,IL1R2,IL33,Irgm1,ISG15,Klrk1,KRT17,LCN2,LIF,MMP9,MX1,Mx2,MYC,OAS2,Oasl2,PDGFB,PHACTR1,PPARA,PPARGC1B,PRF1,PTGS2,RNF213,RSAD2,SELL,SOAT1,SOCS3,STAT1,TBX21,TGFA,TNFSF10,TP53BP2,USP18,ZBP1 | 416 (16) |
| BRD4 | NA | kinase | NA | -4.70e-01 | 0.0e+00 | ABLIM1,AURKB,BCL2L1,BHLHE40,BTG2,CD274,CDKN1A,CXCL2,CXCL3,CXCR4,FOS,FOSL2,GADD45A,GFI1,GLI1,HMOX1,IL6R,IRF4,KCNA3,LCK,LOX,LOXL1,MAP4K1,MYC,MYCN,PDGFB,PLAT,SELE,SESN2,SLC16A9,TGFA,THBS1,TIMP1,WNT5A | 503 (21) |
| APC | -2.10e-01 | enzyme | NA | -4.70e-01 | 0.0e+00 | APCDD1,APOB,CD274,CDKN1A,CHRNA7,CLDN4,CXCL2,CXCL3,EDN1,EREG,GLI1,GLUL,HK2,LCK,MMP9,MYC,PDK4,PPARA,PRKCB,PTGS2,THBS1,TIMP1,TIMP3,TNFRSF12A,TNFRSF19 | 474 (21) |
| NPY | 1.60e-01 | other | NA | -4.70e-01 | 0.0e+00 | CBS/LOC102724560,CRY2,DIO2,FKBP5,FOS,GAL,LPIN1,PCK1,PER1,PNPLA2,TRH | 434 (19) |
| 9Z,11E-octadecadienoic acid | NA | chemical - endogenous mammalian | NA | -4.70e-01 | 1.0e-02 | CPT1B,FASN,IL12B,PTGS2,THBS1 | 477 (19) |
| LCK | -8.00e-01 | kinase | NA | -4.70e-01 | 1.0e-02 | BCL2L1,CD69,FOS,GADD45B,IL2RB,MMP9,MYC,SFPQ,SOX2,XPO1 | 478 (21) |
| N-formyl-Met-Leu-Phe | NA | chemical reagent | NA | -4.70e-01 | 2.0e-02 | CCL2,CCL4,ISG15,MMP8,NFKBIA,PTGS2,SELL | NA |
| EIF4EBP1 | 2.50e-01 | translation regulator | NA | -4.70e-01 | 0.0e+00 | ATF4,CEBPD,CXCL10,HK2,IL12B,MYC,NFIL3,PCK1,PNPLA2,PTGS2 | 409 (17) |
| kaempferol | NA | chemical toxicant | NA | -4.80e-01 | 0.0e+00 | BCL2L1,CD69,CDKN1A,HMOX1,IL1A,MMP9,PTGS2,SELE | 440 (15) |
| Akt | NA | group | NA | -4.80e-01 | 0.0e+00 | ANKRD1,AQP3,AR,ATF4,BCL2A1,BCL2L1,BHLHE40,BMP2,BTG2,CCL2,Ccl2,CD274,CD40LG,CDKN1A,CHST3,CIDEA,COL2A1,CPT1A,CXCL10,CXCR4,ERBB3,EZH2,F3,FASN,FKBP5,FOS,FOSL1,GALNT10,GLI1,HIF3A,HK2,HMOX1,IER3,IL2RB,KCNA5,LCN2,MCAM,MMP9,MYC,MYCN,NFIL3,NFKBIA,NR0B2,PCK1,PDK4,PLG,PPP1R1B,PTGS2,PTX3,SERPINE1,SLC7A5,SOCS3,SOX2,SYT1,THBS1,TNFSF10 | 449 (18) |
| infliximab | NA | biologic drug | NA | -4.80e-01 | 0.0e+00 | BMP2,CCL17,Ccl2,DDIT4,EDN1,G0S2,GZMB,INHBA,LAG3,LTA,NFKBIA,PRF1,PTGS2,SLC7A5,SPHK1,WNT7A | 516 (20) |
| NEIL2 | 5.00e-02 | enzyme | NA | -4.80e-01 | 0.0e+00 | CCL17,CCL19,CCL2,Ccl2,CCL4,CCR3,CD14,CRP,CXCL10,CXCL2,CXCL3,CXCL6,IL1A,IL6R,LTA,LTB,PTGS2,SELE,TLR5 | 440 (12) |
| CORT | NA | other | NA | -4.80e-01 | 0.0e+00 | CCL19,Ccl2,CCL4,CCR3,CXCL10,CXCL3,GHRHR,IL1A | 333 (7) |
| JAG2 | -3.30e-01 | growth factor | NA | -4.80e-01 | 0.0e+00 | BMP2,BMP7,CCL24,CD40LG,CXCL3,CXCL6,IL1A | NA |
| Collagen type I (complex) | NA | complex | NA | -4.80e-01 | 3.0e-02 | CD83,CPB2,EXOC3L2,KDR,MMP9,MYC,PRRX1,PTGS2 | NA |
| leucine | NA | chemical - endogenous mammalian | NA | -4.80e-01 | 0.0e+00 | ATF3,ATF4,Ccl2,CDKN1A,FASN,FOS,MAOA,PPARA | 521 (25) |
| N-cor | NA | group | NA | -4.90e-01 | 0.0e+00 | CDKN1A,CR2,CRP,CXCL10,CXCL2,FASN,HK2,IL1A,Kctd12b,MMP9,PCK1,PDGFB,PTGS2,RAB20,TBX6,TRERF1,USP18 | 529 (20) |
| MAP2K6 | -8.80e-01 | kinase | NA | -4.90e-01 | 0.0e+00 | CCL2,Ccl2,CD83,CDKN1A,CXCL10,IRS1,ISG15,MMP9,Pln,PTGS2,STAT1,TNFSF10 | 489 (20) |
| bardoxolone methyl | NA | chemical drug | NA | -4.90e-01 | 0.0e+00 | BCL2L1,Ccl2,CCL4,HMOX1,MMP9,MYC,PTGS2 | 369 (20) |
| IL36G | NA | cytokine | NA | -4.90e-01 | 0.0e+00 | CD83,CXCL10,CXCL2,IL12B,TBX21,WNT5A | 304 (16) |
| vatalanib | NA | chemical drug | NA | -4.90e-01 | 0.0e+00 | BCL2L1,CDKN1A,KDR,MMP9,TIMP1 | 461 (21) |
| IRS1 | -6.40e-01 | enzyme | NA | -4.90e-01 | 0.0e+00 | ACTC1,BMP6,CEBPD,CIDEA,DLK1,FASN,FOS,HMOX1,IRS1,MYC,MYOCD,NRP1,PCK1,PPARGC1B,TRIM63,TRPC3,WNT5A | 521 (21) |
| Esrra | 1.10e-01 | transcription regulator | NA | -4.90e-01 | 2.0e-02 | ATP1A1,CCL17,CPT1A,ENO3,GZMA,IL1A,PCK1,PDK4,PHKG1,PPP1R1B,PTGS2,SLC28A1 | NA |
| NFIL3 | 1.02e+00 | transcription regulator | NA | -5.00e-01 | 0.0e+00 | CD40LG,CDKN1A,CPT1A,Cyp4a14,FASN,GADD45A,GADD45B,IL12B,PTGS2,TNFSF10 | 578 (24) |
| EGR3 | -9.60e-01 | transcription regulator | NA | -5.00e-01 | 0.0e+00 | ATF3,BCL2L1,BHLHE40,CBLB,CCR9,CHST7,DOK2,FRAT2,IL21R,IL6R,MYC,NFIL3,NGFR,PDE4A,PLAUR,PLXND1,PPL,RAB20,RAB37,SOCS3,SPECC1,XKRX,ZEB2 | 437 (15) |
| GFI1 | -7.80e-01 | transcription regulator | NA | -5.00e-01 | 0.0e+00 | BTLA,Ccl2,CCR10,CDKN1A,CXCR4,FOSL2,GADD45G,GFI1,GIMAP4,GZMA,IL1A,IL6R,IRAK2,ITGB7,JAK3,LPAR1,LTA,MAFF,MYC,NFKBIA,Pmaip1,RAPGEF4,RASGRP1,STAT1,TESC | 487 (17) |
| PLP1 | -8.00e-02 | other | NA | -5.10e-01 | 0.0e+00 | ATF3,ATF4,CCL2,Ccl2,CCR6,CXCL2,TIMP1 | 431 (20) |
| iron | NA | chemical - endogenous mammalian | NA | -5.10e-01 | 0.0e+00 | BMP6,CDKN1A,FTL,GADD45A,GADD45B,GADD45G,HMOX1,LCN2,Mt1,NFYA,TFR2 | 442 (20) |
| UCHL1 | 5.10e-01 | peptidase | NA | -5.10e-01 | 1.0e-02 | BCL2L1,CDKN1A,FCER2,GABARAPL1,KLHL23/PHOSPHO2-KLHL23,LPIN1,PURG,SERPINE1,STXBP4,UBA7 | 392 (11) |
| FGF21 | 7.00e-02 | growth factor | NA | -5.10e-01 | 0.0e+00 | CIDEA,CPT1A,CPT1B,DIO2,ERN1,FASN,FGFR4,FOS,MMP9,PCK1,PDK4,PPARA,PPARGC1B,SERPINE1 | 537 (24) |
| ROCK | NA | group | NA | -5.20e-01 | 0.0e+00 | BMP2,CCL2,CDKN1A,F3,FOS,MYC,Nes,NGFR,THBS1 | 482 (20) |
| RARRES2 | 2.20e-01 | transmembrane receptor | NA | -5.20e-01 | 0.0e+00 | CCL2,Ccl2,CD274,CXCL2,CXCL3,FASN | 422 (16) |
| EML4-ALK | NA | fusion gene/product | NA | -5.20e-01 | 0.0e+00 | BMP2,CCNA1,CD274,CDKN1A,DUSP1,ERBB3,GADD45B,HIPK2,IL24,IL4R,IL6R,IRF4,JUNB,SERPINE1,SOCS3 | 436 (19) |
| Mir122a,b | NA | group | NA | -5.20e-01 | 0.0e+00 | ANKRD1,BCL2L1,Ccl2,CD69,CXCL2,CXCL3,GALNT10,GZMA,MMP9,PLAUR,PTGS2 | 427 (15) |
| ritonavir | NA | chemical drug | NA | -5.20e-01 | 0.0e+00 | ABCB1,ABCC2,ATP10B,BCL2L1,CEP70,FGFBP1,GBP2,HUNK,IFRD1,IKBKE,MAOB,MMP9,MYC,SELE,SLC39A10,TMPRSS4,USP18 | 371 (18) |
| bisindolylmaleimide iv | NA | chemical drug | NA | -5.30e-01 | 4.0e-02 | FOS,MYC,PCK1,PRKCH | NA |
| TLR8 | -4.70e-01 | transmembrane receptor | NA | -5.30e-01 | 1.0e-02 | CCL2,Ccl2,CCL4,CD83,CXCL10,CXCL2,IL12B | NA |
| dactolisib | NA | chemical drug | NA | -5.30e-01 | 0.0e+00 | CDKN1A,DDIT4,ERBB3,MAP1LC3B,MYC,P4HA1,P4HA2,SLC16A3,TGFA,TPBG | 538 (24) |
| MRGPRX3 | 2.00e-02 | G-protein coupled receptor | NA | -5.40e-01 | 0.0e+00 | ARG2,Ccl2,CCL4,CD274,CSF3R,CXCL10,CXCL3,CXCR4,GRINA,IL1A,INHBA,MGAM,S100A8,SELL | NA |
| mir-221 | NA | microRNA | NA | -5.40e-01 | 4.0e-02 | KDR,MEOX2,MMP9,TIMP3,ZEB2 | NA |
| 4-phenylbutyric acid | NA | chemical - endogenous mammalian | NA | -5.40e-01 | 0.0e+00 | ASPA,ATF4,CCL2,Ccl2,CDKN1A,CLDN5,EDEM1,ERN1,LGI1,MMP9,NUPR1,PEX11A,PTGS2,SAT1,SOCS3 | 493 (24) |
| LHX1 | 2.00e-02 | transcription regulator | NA | -5.40e-01 | 0.0e+00 | AADAT,ATP1B1,BHMT2,C7orf57,CUBN,CXCR4,FABP3,HNF4A,MMP8,MMP9,OVOL2,SLC26A1,SLC47A1,SOSTDC1,TRH | NA |
| concanavalin a | NA | chemical drug | NA | -5.50e-01 | 0.0e+00 | BCL2A1,BCL2L1,Ccl2,CCL4,CD40LG,CD69,CDKN1A,CHRNA7,CXCL10,CXCL2,EGR3,IRF4,KCNA3,MAP3K8,MMP9,NR0B2,PTGS2,SDC4,SOCS3,STAT1,TBX21,TNFRSF18,TNFSF10,TP73,XCL1,XCR1 | 457 (15) |
| BTK | -3.20e-01 | kinase | NA | -5.50e-01 | 0.0e+00 | BCL2A1,BCL2L1,CCL4,CD274,CD69,CDKN1A,CXCL10,CXCL3,CXCR4,HMOX1,IFI44L,IFIT1,IL12B,IL1A,IL21R,IRF4,ISG15,MX1,MYC,OAS2,SELP,SPN,STAT1 | 487 (16) |
| chrysin | NA | chemical - endogenous non-mammalian | NA | -5.60e-01 | 0.0e+00 | ADORA2B,AQP3,CCL2,CXCL10,GCLC,HMOX1,IL6R,SELE | 467 (21) |
| ESRRG | -1.06e+00 | ligand-dependent nuclear receptor | NA | -5.60e-01 | 0.0e+00 | ACTC1,CCL28,CDKN1A,DYSF,FABP3,HK2,IL12B,KCNJ11,LPIN1,NEXN,NR0B2,NRP1,PCK1,PDHA1,PDK4,PPARA,RYR2,TRIM63 | 399 (12) |
| IL1RL2 | -1.80e-01 | transmembrane receptor | NA | -5.60e-01 | 0.0e+00 | CD83,CXCL10,CXCL2,MMP9,S100A8 | 295 (12) |
| AXIN1 | NA | other | NA | -5.60e-01 | 1.0e-02 | APCDD1,CD274,CSRNP1,ENC1,FOS | 478 (19) |
| diosgenin | NA | chemical - endogenous non-mammalian | NA | -5.60e-01 | 1.0e-02 | ABCC2,EDN1,F3,PTGS2,SERPINE1 | 445 (16) |
| EGOT | NA | other | NA | -5.60e-01 | 0.0e+00 | CXCL10,ISG15,MX1,OAS2,RSAD2,USP18 | NA |
| hydroxyurea | NA | chemical drug | NA | -5.60e-01 | 0.0e+00 | ABCB1,CCL2,CDKN1A,CXCL2,CXCL3,EDN1,GADD45A,IFIT1,IL1A,LGALS12,MCAM,MX1,MYC,PDE4A,SELE,STAT1,TP73 | 454 (20) |
| NR4A1 | 1.80e-01 | ligand-dependent nuclear receptor | NA | -5.60e-01 | 0.0e+00 | APOB,ATF3,ATP6V1E2,Ccl2,CD69,CIDEA,CLDN5,ELK3,ENO3,FASN,G0S2,HCAR1,HDC,HK2,HMOX1,IL12B,KCNIP3,LPIN1,MMP8,MMP9,Mt1,MYCN,NFKBIA,PCK1,PDHA1,PDK4,PHKG1,PPP1R3C,RAMP3,SAT1,SERPINE1,SOAT1,TNFSF10 | 527 (22) |
| SRD5A1 | -4.30e-01 | enzyme | NA | -5.60e-01 | 0.0e+00 | AR,CREB1,FASN,IRS1,LCN2,Mt1,PCK1,PNPLA2 | NA |
| pristane | NA | chemical toxicant | NA | -5.60e-01 | 1.0e-02 | CCL19,Ccl2,CXCL10,IL12B,ISG15,Oasl2,PTGS2,Siglech | 359 (14) |
| Cdc42 | -1.10e-01 | enzyme | NA | -5.70e-01 | 2.0e-02 | Ccl2,COL2A1,CTSH,CTSV,EREG,GFI1,LIF,NPC2,TNFRSF12A,TNFRSF13C | NA |
| rosiglitazone | NA | chemical drug | NA | -5.70e-01 | 0.0e+00 | ADAMTS1,ADGRE1,ANGPTL3,AOC1,AQP3,ATP1A1,CCL17,CCL2,Ccl2,CDKN1A,CIDEA,CIITA,CPT1A,CPT1B,CREB1,CRP,CXCL10,DIO2,EDN1,EDNRA,F3,FABP3,FASN,FOS,FOSL1,GBP2,H6PD,HAS1,HCAR1,HMOX1,HSD11B2,IL12B,IL1A,IL21R,INHBA,IRS1,ITGAD,LCN2,LOX,LPIN1,MMP9,NPR3,OAS2,PCK1,PDHA1,PDK4,PECR,PEX11A,PLCL1,PLIN5,PNPLA2,PPARA,PPARGC1B,PTGS2,PTPRO,RBP4,S100A8,SERPINE1,SOAT1,SOCS3,SPN,SPON2,STAT1,TBX21,THBS1,TIMP1,TRIM63 | 517 (19) |
| AICAR | NA | chemical - endogenous mammalian | NA | -5.70e-01 | 1.0e-02 | ATF4,CCNA1,CDKN1A,CPT1B,FASN,HK2,MMP9,PDK4,PNPLA2,PPARA,SERPINE1,SESN2,SOCS3,TXNIP | 486 (19) |
| MACROH2A1 | NA | other | NA | -5.80e-01 | 0.0e+00 | ASB2,CDKN1A,CTHRC1,EDN1,FASN,FSTL3,GADD45A,HIF3A,IRS1,LTB,MAP2K6,PTPRO,SERPINE1,SOCS2,SOX2 | 276 (9) |
| H2AZ1 | NA | other | NA | -5.80e-01 | 0.0e+00 | ALB,AURKB,CCNA1,CD69,CDKN1A,CXCR4,HNF4A,MYC,WNT7A | 191 (5) |
| elaidic acid | NA | chemical - endogenous mammalian | NA | -5.80e-01 | 0.0e+00 | ANGPTL3,DLK1,FASN,HPX,HSD17B2,LCN2,LPIN1,NPC2,PNPLA3,PPP1R3C,SERPINC1,SOAT1 | NA |
| silibinin | NA | chemical drug | NA | -5.80e-01 | 5.0e-02 | CDKN1A,HK2,MMP9,MYC,NFKBIA,PLAUR,PTGS2,ZEB2 | NA |
| Nfat (family) | NA | group | NA | -5.90e-01 | 0.0e+00 | ATF3,CCL2,CD40LG,F2RL1,FCER2,IL12B,IRF4,LAG3,LTA,PDGFB,PGM2L1,PTGS2,SDC4,SELE,SERPINE1,SLC7A1,TLR10 | 411 (18) |
| dacinostat | NA | chemical drug | NA | -5.90e-01 | 2.0e-02 | ABL1,BCL2L1,CDKN1A,CEBPD | NA |
| MK2206 | NA | chemical drug | NA | -5.90e-01 | 2.0e-02 | ATF4,CD274,HK2,MYC,PFKFB3,SOX2 | NA |
| DLX3 | 0.00e+00 | transcription regulator | NA | -5.90e-01 | 0.0e+00 | CDKN1A,EPGN,EREG,IL1A,MMP9,PGF | 360 (13) |
| epoprostenol | NA | chemical - endogenous mammalian | NA | -5.90e-01 | 0.0e+00 | ANGPTL3,FOS,PTGS2,RGS18,SERPINE1 | 459 (22) |
| Pde4 | NA | group | NA | -5.90e-01 | 3.0e-02 | CCL2,CD14,CD163,CDKN1A | NA |
| SLC7A2 | -1.50e-01 | transporter | NA | -6.00e-01 | 0.0e+00 | CCL4,CXCL10,CXCL2,CXCL3,CXCL6 | 122 (4) |
| FABP1 | -5.00e-01 | transporter | NA | -6.00e-01 | 1.0e-02 | FASN,HMOX1,PNPLA2,PNPLA3,PPARA | 452 (20) |
| ITPR2 | 1.00e-01 | ion channel | NA | -6.10e-01 | 0.0e+00 | AFAP1L2,CCL2,Ccl2,CCL4,CD180,CD274,CXCL10,CXCL6,Igtp,Irgm1,PCK1,SEMA7A,SLC11A1,TLR5 | 288 (10) |
| pioglitazone | NA | chemical drug | NA | -6.10e-01 | 1.0e-02 | APOB,AQP1,ATF4,Ccl2,Ccr2,CDKN1A,CEBPD,CXCL10,FOS,FOSL1,HAS1,HMOX1,IRS1,LPIN1,MMP9,PPARGC1B,PTGS2,RBP4,SERPINE1,SOAT1 | 499 (23) |
| tranylcypromine | NA | chemical drug | NA | -6.10e-01 | 0.0e+00 | CD274,CDKN1A,CXCL10,FOS,MMP9,PDE4A,RASSF1 | 369 (11) |
| APP | 2.20e-01 | other | NA | -6.10e-01 | 0.0e+00 | ABL1,ADAMTS4,AK1,ALB,ARRDC3,ATF4,ATP1B1,BCL2L1,BMP6,BRPF1,CA12,CCL2,Ccl2,CCL4,CCNA1,CD5L,CD69,CDKN1A,CHRNA7,CKMT1A/CKMT1B,CLDN5,CMPK2,CRYM,CTSV,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,CYP26B1,EDN1,ERN1,F2RL1,FABP3,FOS,GBP2,GBP4,HIPK2,HMOX1,Igtp,IL12B,IL1A,INHBA,IRF4,Irgm1,JUNB,KYNU,LGALS3,LIF,LIMK1,LMO4,MAFF,Meis1,MERTK,MMP8,MMP9,Mt1,Mx2,MYC,NCDN,Nes,NGFR,Nrgn,NRP1,PAX5,Pcp4l1,PDGFB,PFKFB3,PLAT,Pmaip1,POU2AF1,PRIMA1,PRKCB,PRKCG,PTGS2,PTPRC,RBM3,RNF213,RSAD2,RUNX1T1,S100A8,SDC4,SERPINE1,SHOX2,SLC13A3,SOCS3,ST8SIA1,STXBP4,TBC1D25,TLR10,TLR5,TNFSF10,TP73,TPPP,UBC,USP18 | 515 (20) |
| AS1842856 | NA | chemical reagent | NA | -6.10e-01 | 0.0e+00 | Acan,CCL2,CDKN1A,COL2A1,CXCL10,GFPT2,PTGS2,TNFSF10,TRIM63 | 125 (4) |
| PRDM1 | -2.20e-01 | transcription regulator | NA | -6.20e-01 | 0.0e+00 | ACOX2,AFF3,AQP3,ARG2,BCL11A,BCL2A1,Bhlhe41,BTLA,Ccl2,CD19,CD22,CD79A,CIITA,CRISPLD2,CRP,CXCL2,CXCL3,CXCL6,CXCR4,DBNDD1,DDIT4,EZH2,F9,FAR2,FCER2,FGA,FNDC5,FOS,FOSL1,GIMAP7,IFIT1,IL1A,IL24,IRF4,KHDRBS3,KRT81,LAG3,LAX1,LGALS3,LRRN1,MYC,OAS2,PAX5,PDE4C,PRF1,PRKCG,RAPGEF3,RGS16,RGS18,RSAD2,S100A8,SELL,SLC16A5,SLC2A5,SLC6A12,SOCS2,STAT1,TBX21,TNFAIP6,TNFRSF14,TNFSF10,TRIB1,VSX2 | 526 (22) |
| carvedilol | NA | chemical drug | NA | -6.20e-01 | 1.0e-02 | F3,FASN,HMOX1,MMP9,MYC,NPR3 | 406 (21) |
| miR-24-3p (and other miRNAs w/seed GGCUCAG) | NA | mature microRNA | NA | -6.30e-01 | 4.0e-02 | AURKB,DUSP1,JPH2,MYC,Pmaip1 | NA |
| SPARC | 2.20e-01 | other | NA | -6.30e-01 | 4.0e-02 | ARG2,BHLHE40,CCL19,CEBPD,CLDN4,CPT1B,ISG15,LYVE1,SERPINE1,STAT1,TMC5,UBE2U | NA |
| estriol | NA | chemical - endogenous mammalian | NA | -6.30e-01 | 0.0e+00 | CCL2,Ccl2,CCL4,CXCL10,CXCL2,CXCL3,CXCL6,IRS1,LTA,SELE | 601 (21) |
| HOXD10 | NA | transcription regulator | NA | -6.30e-01 | 0.0e+00 | CLEC10A,MAOB,NCS1,NUDT5,RSAD2,SERPINE1,ST8SIA2,TFR2,TIMP1,TNFSF8 | NA |
| 2’3’-cyclic guanosine monophosphate-adenosine monophosphate | NA | chemical - endogenous mammalian | NA | -6.30e-01 | 0.0e+00 | CCL4,CIITA,CXCL10,IFIT1,ISG15,Mx2,OAS2,RSAD2,SOCS3 | 357 (20) |
| CREB3L3 | -7.00e-01 | transcription regulator | NA | -6.40e-01 | 0.0e+00 | APCS,CRP,CYP7B1,LPIN1,PCK1,PPARA | 66 (3) |
| TCL1A | NA | transcription regulator | NA | -6.40e-01 | 0.0e+00 | C3AR1,Cd209b,CD5L,CSF3R,CTSH,CXCL3,FKBP5,FOS,HMOX1,IL1R2,LCN2,MMP8,MMP9,PTPRO,Retnlg,S100A8,SEMA7A,SLC11A1 | 490 (19) |
| ACVRL1 | 4.00e-02 | kinase | NA | -6.40e-01 | 0.0e+00 | CDKN1A,CXCR4,KDR,LYVE1,MYC,PLAT,PLAUR,SELE,SERPINE1,STAT1 | 437 (20) |
| HSD11B1 | 9.00e-02 | enzyme | NA | -6.40e-01 | 0.0e+00 | CCL2,CPT1A,CPT1B,FASN,FGA,IL12B,PDK4,PFKFB3,PNPLA2,PPARA | 497 (26) |
| V-PYRRO/NO | NA | chemical reagent | NA | -6.40e-01 | 0.0e+00 | CXCL2,CXCL3,GZMA,HMOX1,THBS1,TNFSF10 | 225 (9) |
| PTPN2 | 1.90e-01 | phosphatase | NA | -6.40e-01 | 0.0e+00 | BCL11B,CCL17,CIDEA,IL12B,JAK3,STAT1,TMEM26 | NA |
| diazoxide | NA | chemical drug | NA | -6.40e-01 | 0.0e+00 | BCL2L1,FASN,KCNJ11,MYC,ODC1,PTPRN | 535 (24) |
| maslinic acid | NA | chemical - endogenous non-mammalian | NA | -6.40e-01 | 1.0e-02 | BCL2L1,CDO1,JUNB,MAP2K6,PLAUR,PNPLA2,PPARA,PRKCB,PTGS2,SLC5A1,THBS1,WNT5A | 456 (13) |
| EFNA4 | -3.80e-01 | kinase | NA | -6.40e-01 | 2.0e-02 | FOSL1,KRT7,KRT75,PKP1,PLAT,TGM1 | NA |
| BMPR1A | -8.00e-02 | kinase | NA | -6.40e-01 | 4.0e-02 | Acan,CDKN1A,COL2A1,INHBA,PTX3,SERPINE1 | NA |
| OGT | -5.90e-01 | enzyme | NA | -6.40e-01 | 0.0e+00 | BCL2L1,Ccl2,CDKN1A,CXCL2,CXCL3,FASN,FOS,GLI1,MYC,NGFR,PCDH20,RGS16,SEMA4F,TET1,TMEM132D | 490 (26) |
| IRF2 | 6.00e-02 | transcription regulator | NA | -6.40e-01 | 0.0e+00 | C1QTNF1,CA12,CD14,CD274,CDKN1A,CIITA,CLEC10A,CXCL10,FGA,HK2,IL12B,ISG15,LCN2,PFKFB3,PTGS2,SLC7A1,TLR5,TNFSF10,TXNRD1,USP18 | 254 (16) |
| AHR | -3.70e-01 | ligand-dependent nuclear receptor | NA | -6.40e-01 | 0.0e+00 | ADAMTS5,ADGRE1,ALB,ARG2,ATP1B1,BTG2,CCL19,Ccl2,CCR6,CCR9,CD14,CD274,CD28,CD3G,CD40LG,CD84,CD8A,CDKN1A,CDO1,CDON,CERS6,CLCA1,CRP,CX3CR1,CXCL10,CXCL2,CYP2S1,DCLK3,DIO1,EDN1,EREG,ESRRG,FASN,FMO3,FOS,FOSL1,GADD45A,Gsta1,HK2,HUNK,IKZF3,IL1R2,IL21R,IL2RB,IRF4,ITGA7,ITGAD,ITIH4,JUNB,LAMA5,LCK,MCAM,MGP,MMP8,Mt1,MYC,NEDD9,PCK1,Pcp4l1,PDGFB,PLAT,PTGS2,PTX3,RASGRP1,SERPINE1,SHB,SLAMF6,SLC16A5,SLC22A7,SOCS3,SOX2,STEAP2,THBS1,TIMP3,TLR5,TNFRSF14,TNFRSF18,TNFRSF19,TP73 | 511 (18) |
| ACE2 | -1.80e-01 | peptidase | NA | -6.50e-01 | 0.0e+00 | CCL2,Ccl2,CXCL10,CXCL2,CXCL3,IL12B,MMP9,PTGS2,SERPINE1 | 301 (12) |
| TCR | NA | complex | NA | -6.50e-01 | 0.0e+00 | ABLIM1,ADORA2A,BCL2A1,BCL2L1,BTLA,CBLB,CCL17,CCL4,CCR3,CCR6,CCR9,CD27,CD28,CD40LG,CD69,CREB1,CXCL10,CXCR4,EBNA1BP2,FOS,GADD45B,GADD45G,GBP4,GFI1,GZMA,GZMB,IFI44,IFI44L,IFIT1,IL24,IL4R,IRF4,ISG15,ITGB7,JUNB,KCNK5,LCK,LPIN2,LTA,MAP3K8,MX1,MYC,MYCN,NFKBIA,NRP1,ODC1,PRF1,PTPRC,RASGRP1,RGCC,RSAD2,SELL,SOCS2,SOCS3,SPHK1,STAT1,TBX21,TLE3,TLR10,TNFRSF12A,TNFRSF18,XCL1 | 480 (20) |
| FSHR | NA | G-protein coupled receptor | NA | -6.50e-01 | 0.0e+00 | AR,CLDN11,DUSP1,GZMB,INHBA,NPR3,PCK1,PLA1A,PLAT,ZNF519 | 428 (18) |
| pregna-4,17-diene-3,16-dione | NA | chemical - endogenous non-mammalian | NA | -6.60e-01 | 0.0e+00 | ABCB11,BCL2A1,BCL2L1,MMP9,MYC,PTGS2 | 424 (15) |
| mir-150 | NA | microRNA | NA | -6.60e-01 | 0.0e+00 | CCR6,CLDN5,CXCL2,CXCR4,EDN1,GZMB,Klrk1,MMP16 | 253 (10) |
| zinc protoporphyrin IX | NA | chemical - endogenous mammalian | NA | -6.60e-01 | 1.0e-02 | CDKN1A,GCLC,HMOX1,PTGS2 | 521 (24) |
| MLX | 1.00e-01 | transcription regulator | NA | -6.60e-01 | 0.0e+00 | ATF3,Ccl2,CPT1A,DIO1,FASN,MYCN,TIMP1,TXNIP | 208 (7) |
| TGFB1I1 | -5.00e-02 | transcription regulator | NA | -6.60e-01 | 4.0e-02 | AR,CDKN1A,FOS,SERPINE1 | NA |
| topotecan | NA | chemical drug | NA | -6.60e-01 | 0.0e+00 | ARL15,ATF3,ATF4,BCL2A1,Bhlhe41,CAMK1D,CCL2,Ccl2,CCL4,CD14,CD83,CDKN1A,CEBPD,CTSW,CXCL10,CXCL3,EDN1,EGR3,ERBB3,FOS,FUBP1,GADD45B,IL1A,IRS1,JAK3,JUNB,MAP3K8,MYC,MYCN,NFKBIA,PHKG1,PTGS2,RBFOX1,SELP,SESN2,SFPQ,SLC7A5,SOCS3,ZFP36 | 443 (18) |
| bafilomycin A1 | NA | chemical drug | NA | -6.60e-01 | 0.0e+00 | BCL2L1,CD83,CXCL10,IRS1,KCNA5,MS4A1,NFKBIA,NR0B2,PTGS2,SLC7A1 | 534 (19) |
| helenalin | NA | chemical - endogenous non-mammalian | NA | -6.70e-01 | 0.0e+00 | ATF4,CXCL3,CXCL6,HMOX1,MMP9,NFKBIA,PTGS2 | 323 (17) |
| GSK2816126 | NA | chemical drug | NA | -6.70e-01 | 2.0e-02 | Ccl2,CXCL10,DLK1,IL12B,KCNMB4,RBP4,SOSTDC1,TNFSF10 | NA |
| NKX2-5 | NA | transcription regulator | NA | -6.80e-01 | 0.0e+00 | ADORA1,ANKRD1,DIO2,ECE1,MYCN,MYOCD,Nes,NR5A2,RYR2 | 221 (7) |
| EIF2A | 3.00e-01 | translation regulator | NA | -6.90e-01 | 4.0e-02 | ATF4,CRP,LCN2,PTPRC | NA |
| desipramine | NA | chemical drug | NA | -6.90e-01 | 0.0e+00 | CDKN1A,FGFBP1,FOS,HMOX1,Nes,PDE4A | 425 (17) |
| SOX6 | -4.20e-01 | transcription regulator | NA | -6.90e-01 | 0.0e+00 | Acan,BMP6,CDKN1A,COL2A1,MYC,SOCS3 | 503 (25) |
| curdlan | NA | chemical - endogenous non-mammalian | NA | -6.90e-01 | 2.0e-02 | CD69,CXCL2,FOS,IL2RB,MMP9 | NA |
| dasatinib | NA | chemical drug | NA | -6.90e-01 | 5.0e-02 | ANKRD1,BCL2L1,CDKN1A,CXCL10,IL12B | NA |
| pentoxifylline | NA | chemical drug | NA | -6.90e-01 | 1.0e-02 | BCL2L1,Ccl2,CXCL3,FGA,FOS,NFKBIA,TIMP1 | 441 (16) |
| candesartan | NA | chemical drug | NA | -6.90e-01 | 2.0e-02 | Ccl2,CREB1,FOS,FOSL2,NPR3,SERPINE1,TRPC3 | NA |
| etoposide | NA | chemical drug | NA | -7.00e-01 | 0.0e+00 | ABCB1,ATF3,BANK1,BCL2A1,BCL2L1,CCL2,CCNA1,CD274,CDKN1A,CXCL10,CXCL2,CXCL3,DDIT4,DUSP1,FANCG,FASN,GADD45A,GADD45G,GBP2,GZMB,HK2,IER3,IFI44L,IL1A,IL2RB,KCNK1,MERTK,MYC,OAS2,ODC1,Pmaip1,PRF1,PTGS2,SELL,SFN,SLC16A4,SPHK1,STAT1,TNFSF10,TP73,UBA7 | 461 (21) |
| N6AMT1 | 5.40e-01 | enzyme | NA | -7.00e-01 | 1.0e-02 | APCDD1,AQP1,CC2D2A,CDCA7,CDKN1A,CDO1,DACH1,FGFR4,IRS1,KLHL23/PHOSPHO2-KLHL23,MPP3,PTPRO,SLC39A10,SMO,SOAT1,TNFSF10,ZBTB12 | NA |
| PTK2 | -1.60e-01 | kinase | NA | -7.00e-01 | 0.0e+00 | Ccl2,CDKN1A,FOS,IRS1,MMP9,P4HA1,PRRX1,SERPINB1,THBS1,TIMP1,TIMP3,TLL1 | 464 (21) |
| CLEC7A | 2.80e-01 | transmembrane receptor | NA | -7.00e-01 | 0.0e+00 | CCL17,CCL2,CCL4,CLCA1,CXCL2,IL12B,IL33,PTGS2 | 411 (19) |
| mir-130 | NA | microRNA | NA | -7.10e-01 | 0.0e+00 | ABCB1,CCL2,Ccl2,GADD45A,KDR,LCN2,PPARA,PTGS2 | 536 (17) |
| SRF | -2.20e-01 | transcription regulator | NA | -7.10e-01 | 0.0e+00 | ACTC1,ANKRD1,APOLD1,ARHGAP20,ATF3,BCL2L1,BMP2,CD19,CDKN1A,CEBPD,CLDN5,CXCR4,EGR3,FCN1,FOS,FOSL1,G0S2,GADD45A,GADD45G,GFI1,GPATCH4,HIF3A,HMOX1,ITGA2B,JUNB,KDR,LCN2,MMP9,MYOCD,OPHN1,Pcp4l1,PGLYRP1,PTGS2,RND3,S100A8,SELP,SOSTDC1 | 431 (22) |
| CASZ1 | -3.00e-01 | enzyme | NA | -7.10e-01 | 0.0e+00 | Acan,CCL17,COL2A1,EDN1,ITGA7,PPP1R1B,Sik1,SLC24A2 | NA |
| SKIC2 | NA | enzyme | NA | -7.10e-01 | 0.0e+00 | BHLHE40,DDIT4,HK2,IL33,P4HA1,S100A8,SLC6A6,SLC7A5 | NA |
| MNT | NA | transcription regulator | NA | -7.10e-01 | 0.0e+00 | ATP1B1,CD300LB,GADD45B,GPR55,MYC,ODC1,SERPINH1,TMEM252,TXNIP | NA |
| ARID2 | -1.50e-01 | transcription regulator | NA | -7.10e-01 | 1.0e-02 | BLK,CD274,FOS,HAS1,IL1A,PTPRN,THBS1,WNT5A | NA |
| EFNA2 | -2.10e-01 | kinase | NA | -7.10e-01 | 1.0e-02 | FOSL1,KRT7,KRT75,NEDD4L,NFIL3,PKP1,PLAT,TGM1 | NA |
| 1810019D21Rik | NA | other | NA | -7.10e-01 | 1.0e-02 | ABCB1,CDKN1A,EDN1,MMP9,MYCN,RAPGEF3,S100A8,WNT7A | NA |
| RAG2 | NA | enzyme | NA | -7.10e-01 | 3.0e-02 | ANKRD1,C5orf63,CTSW,CXCL10,EPHA4,IL21R,IL4R,ISG15,NKD2,SMPD3,STAT1 | NA |
| AKT inhibitor VIII | NA | chemical reagent | NA | -7.10e-01 | 0.0e+00 | CCL2,CD28,F3,GZMA,GZMB,GZMM,HSD11B2,MYC,SELL,TNFSF10 | 509 (21) |
| paraquat | NA | chemical toxicant | NA | -7.10e-01 | 0.0e+00 | ADGRE1,BCL2L1,CCL19,CEBPD,EDN1,GCLC,HMOX1,INHBA,KCNA2,LPIN2,MAPK15,MMP8,MMP9,Mt1,PTGS2,SFTPB,STON2,TBCK,TIMP1 | 440 (19) |
| linoleic acid | NA | chemical - endogenous mammalian | NA | -7.20e-01 | 0.0e+00 | APOB,Ccl2,CPT1A,CPT1B,DUSP1,EDN1,FASN,KDR,NEDD4L,NFKBIA,PLIN5,PTGS2,S100A8 | 448 (19) |
| arginine | NA | chemical - endogenous mammalian | NA | -7.20e-01 | 0.0e+00 | ALB,ATF4,BCL2L1,CXCL10,DDIT4,HDC,MYC,PTGS2,SLC7A5 | 434 (18) |
| 2-amino-5-phosphonovaleric acid | NA | chemical - other | NA | -7.20e-01 | 0.0e+00 | ADAMTS1,ARID5A,ASB2,ATF4,BBS12,BVES,DCLK2,DKK2,DUSP1,EGR3,FOS,GADD45A,GADD45B,GADD45G,IFRD1,JUNB,KDR,NRN1,Pmaip1,PTGS2,REM2,RUNX1T1 | 371 (18) |
| sirolimus | NA | chemical drug | NA | -7.20e-01 | 0.0e+00 | AGR2,AQP3,AR,ATF4,ATP1A1,ATP2B4,AURKB,BCL2A1,BCL2L1,BMP2,Ccl2,CCR9,CD274,CDKN1A,CX3CR1,CXCR4,DDIT4,ERBB3,F3,FASN,FOS,GCLC,HK2,HMOX1,IL12B,IL33,IL4R,IRS1,ISG15,JUNB,KDR,LCN2,LGALS3,LPIN1,MAP1LC3B,MMP9,Mt1,MYC,ODC1,PDGFB,PDHA1,PLAUR,PTX3,SELL,SERPINE1,SFN,SLC38A3,SLC43A3,SLC6A6,SLC7A5,SNAP23,SOCS3,STAT1,TBX21,TIMP1,UCK2,ZFP36 | 562 (18) |
| HOXA13 | NA | transcription regulator | NA | -7.20e-01 | 1.0e-02 | AR,BMP2,BMP7,DLL1,EPHA4,PTGS2,SOX2,WNT5A | NA |
| LPIN1 | 6.70e-01 | phosphatase | NA | -7.20e-01 | 0.0e+00 | CDKN1A,CPT1A,DLK1,FASN,IL12B,LPIN1,LPIN2,PPARA,PTGS2 | 520 (25) |
| MSR1 | 1.60e-01 | transmembrane receptor | NA | -7.30e-01 | 0.0e+00 | CXCL10,CXCL2,CXCL3,IFIT1,ISG15,MMP9 | 292 (18) |
| 2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine | NA | chemical reagent | NA | -7.30e-01 | 0.0e+00 | CCL2,Ccl2,CXCL10,GNRH1,MMP9,SELE | 500 (15) |
| CD69 | -7.40e-01 | transmembrane receptor | NA | -7.30e-01 | 0.0e+00 | CCL19,CCL24,CD69,CLCA1,CXCL10,SOCS3 | 474 (21) |
| CHRNA7 | 1.42e+00 | transmembrane receptor | NA | -7.30e-01 | 1.0e-02 | Ccl2,CDKN1A,CXCL10,CXCL2,CXCL3,TIMP3 | NA |
| zoledronic acid | NA | chemical drug | NA | -7.30e-01 | 1.0e-02 | BCL2L1,CXCR4,LPAR1,MMP9,PTGS2,TNFSF10,WNT5A | NA |
| CPT1B | -7.00e-01 | enzyme | NA | -7.30e-01 | 1.0e-02 | CBLB,CYP46A1,CYTL1,FABP3,FASN,FUBP1,HK2,IRS1,MKNK2,NFKBIA,PCK1,PDK4,PFKFB3,PHKG1,PPP1R3A,PPP1R3C,SHC2,SOCS2,SOCS3,TNFRSF8 | NA |
| T3-TR-RXR | NA | complex | NA | -7.30e-01 | 2.0e-02 | F10,FASN,FGA,PCK1,SLC16A3,TRH | NA |
| TCF7 | NA | transcription regulator | NA | -7.30e-01 | 0.0e+00 | BCL11B,CD3G,CEBPD,FOS,FOSL1,HNF4A,LCK,PPARA,SOX2 | 307 (10) |
| Gsk3 | NA | group | NA | -7.40e-01 | 0.0e+00 | Acan,ATF4,COL2A1,FASN,FOS,IL12B,IRS1,KDR,MYC,PTGS2,STAT1,TBX21,TBX6 | 485 (22) |
| MGP | 7.50e-01 | other | NA | -7.40e-01 | 0.0e+00 | ALB,CCL28,CCR10,CD274,CXCR4,HNF4A,ITGB7,MYOCD | 221 (7) |
| RELB | 1.30e-01 | transcription regulator | NA | -7.40e-01 | 0.0e+00 | ABCB1,BCL2L1,CCL19,CCR3,CDKN1A,CIITA,IRF4,LTA,LTB,MAP3K8,MYC,NFKBIA,PPARGC1B,PTGS2,TBX21,TGFA,TNFRSF14 | 374 (16) |
| ETS1 | -3.50e-01 | transcription regulator | NA | -7.40e-01 | 0.0e+00 | ABCB1,BCL11A,BCL2L1,CCL2,Ccl2,CD14,CD27,CD69,CD79A,CD79B,CDKN1A,COL2A1,FGFR4,GZMA,HMOX1,IL12B,IL24,IL2RB,ITGA2B,JUNB,Klre1,Klrk1,LCK,LTB,MCAM,MMP9,MYC,NFIL3,PRF1,SELL,SERPINE1,SLAMF6,TBX21,TGFA,ZEB2 | 488 (22) |
| mir-182 | NA | microRNA | NA | -7.40e-01 | 1.0e-02 | CCL2,CCL24,CD163,CLEC10A,GADD45G,IL4R,IRF4,PGF,PRF1,SOCS3 | NA |
| MC4R | -2.00e-01 | G-protein coupled receptor | NA | -7.50e-01 | 0.0e+00 | Ccl2,FASN,FOS,PNPLA2,TRH,UBC | 516 (23) |
| selumetinib | NA | chemical drug | NA | -7.50e-01 | 0.0e+00 | BMX,CD274,CDKN1A,EPHA2,EPHA4,ERBB3,FGFR4,FOS,FOSL1,FOSL2,JAK3,JUNB,LCK,MERTK,WNT7A | 422 (20) |
| FKBP4 | -4.60e-01 | enzyme | NA | -7.50e-01 | 2.0e-02 | FASN,LIF,PDK4,TIMP3 | NA |
| YOD1 | -1.60e-01 | enzyme | NA | -7.50e-01 | 0.0e+00 | ANKRD1,CXCL10,IFIT1,INHBA | 198 (9) |
| parthenolide | NA | chemical drug | NA | -7.50e-01 | 0.0e+00 | ADAMTS5,ANKRD1,BCL2L1,CCL2,Ccl2,CLDN5,CXCL2,CXCL3,HMOX1,LIF,MMP9,PDK4,PTGS2 | 337 (11) |
| troglitazone | NA | chemical drug | NA | -7.60e-01 | 0.0e+00 | ABCB11,Acot1,AQP3,AR,ATF3,ATP10B,BCL2L1,CCL2,Ccl2,CDKN1A,CEBPD,CEP70,CIB2,CIITA,CPT1B,CREB1,CXCL10,CXCL3,CXCL6,FABP3,FASN,FOS,FOSL1,G0S2,GADD45A,GBP2,HIPK2,HMOX1,HUNK,IFRD1,IRS1,MAOB,MMP9,MYC,NFKBIA,P4HA1,PCK1,PDK4,PEMT,PEX11A,PPARA,PTGS2,SELE,SERPINE1,SLC39A10,TMPRSS4,USP18 | 540 (20) |
| REL | -2.10e-01 | transcription regulator | NA | -7.60e-01 | 0.0e+00 | BCL2A1,BCL2L1,CCL2,CCL4,CD40LG,CDKN1A,CIITA,CR2,CREM,CTSV,CXCL10,CXCL3,DCLRE1B,DDX11,EZH2,F3,FCER2,FOS,FOSL1,GADD45B,IER3,IL12B,IRF4,KDR,MAP3K8,MMP9,MYC,NFKBIA,PIPOX,RSAD2,SLC7A6,TNFRSF13C,TNFSF10,TTC30B | 445 (16) |
| BMPR1B | NA | kinase | NA | -7.60e-01 | 2.0e-02 | Acan,CDKN1A,COL2A1,PTGS2,SERPINE1 | NA |
| NX-13 | NA | chemical drug | NA | -7.60e-01 | 2.0e-02 | CCL2,Ccl2,CXCL2,IL1A | NA |
| cinnamaldehyde | NA | chemical toxicant | NA | -7.60e-01 | 0.0e+00 | Akr1b10,BCL2L1,Ccl2,CIDEA,CPT1A,CPT1B,DDIT4,FOS,GCLC,HMOX1,MARK4,ODC1,PDK4,PNPLA2,PPARA,PTGS2,SELE,TRIM16,TRPA1,TXNIP | 491 (15) |
| IRF8 | -3.30e-01 | transcription regulator | NA | -7.70e-01 | 0.0e+00 | ADGRE1,ATF3,BANK1,BCL2L1,CCR6,CD14,CD37,CD83,CDKN1A,CIITA,CREM,CSF3R,CXCL10,FOS,IFI44L,IGSF9B,IL12B,IRF4,ISG15,KCNJ5,LIF,MMP9,MS4A1,MYC,OAS2,Oasl2,Pmaip1,SEZ6,STAT1,TNFSF10,ZEB2 | 425 (20) |
| VHL | -8.00e-02 | transcription regulator | NA | -7.70e-01 | 0.0e+00 | ATF4,BCL2L1,BHLHE40,CA12,CDKN1A,CLDN4,CXCR4,F3,FTL,HK2,HMOX1,IER3,LOX,NEDD9,PDGFB,PFKFB3,SIGLEC8,SLC16A3,TGFA,TNFSF10 | 479 (18) |
| CL097 | NA | chemical reagent | NA | -7.70e-01 | 0.0e+00 | CD274,CXCL10,IL12B,MX1,TNFSF10 | 169 (11) |
| MAT1A | -1.80e-01 | enzyme | NA | -7.70e-01 | 5.0e-02 | ALB,ATP1B1,Cyp4a14,Mt1 | NA |
| CD28 | -6.40e-01 | transmembrane receptor | NA | -7.70e-01 | 0.0e+00 | BCL2A1,BCL2L1,BHLHE40,CBLB,CCL4,CCR6,CCR9,CD27,CD274,CD28,CD40LG,CD69,CREM,CXCL2,CXCR4,FOS,GBP2,GLI1,GPR37,GZMA,GZMB,HK2,IL21R,IRF4,ITGB7,LTA,MYC,NFKBIA,ODC1,PDE4A,PTGS2,RGCC,SLC16A3,SLC7A1,SLC7A5,SOCS2,SOCS3,STEAP2,TBX21,TFPI2,THBS1,TNFRSF18,TNFSF10,TNFSF18,XCL1 | 405 (18) |
| Hdac | NA | group | NA | -7.80e-01 | 0.0e+00 | ADAMTS1,ATF3,BCL2L1,BMP2,CDKN1A,CXCR4,DLL1,EDN1,EDN3,EDNRA,EGR3,EZH2,FOS,FOSL1,GADD45B,IL6R,MEOX1,MEOX2,MYC,MYCN,NRP1,OSR1,PGF,SMO,SMPD3,TNFSF10,TXNIP,ZEB2 | 525 (19) |
| laquinimod | NA | chemical drug | NA | -7.80e-01 | 0.0e+00 | ADAMTS15,ADAMTS9,CNGA3,DNAH2,F10,FKBP5,FNDC5,HDC,IL1R2,LPAR1,MMP8,PGF,PHACTR1,PPP1R14D,PPP1R3C,SCIN,SMIM3,STBD1,SYT15 | NA |
| KLF1 | 6.00e-02 | transcription regulator | NA | -7.80e-01 | 0.0e+00 | AQP1,BCL11A,CDKN1A,EPB42,IL12B,ITGA2B,SERPINH1,SLC43A1,TFR2 | 221 (7) |
| IFNG | NA | cytokine | NA | -7.80e-01 | 0.0e+00 | AADAT,ABCB1,Acot1,ADAMTS9,ADCY5,ADGRG2,ADORA1,ADORA2A,ADORA2B,AQP1,ARG2,ARNT2,ATF3,ATF4,ATP1A1,ATP1B1,AZGP1,BCL2A1,BCL2L1,BMP2,BMP6,CCL17,CCL19,CCL2,Ccl2,CCL28,CCL4,CCNA1,CCNO,CCR3,CCR6,CD14,CD163,CD27,CD274,CD40LG,CD5L,CD83,CDKN1A,CEBPD,CERS6,CHST3,CHST7,CIITA,CIRBP,CKMT1A/CKMT1B,CLEC10A,CMPK2,CREM,CTSH,CTSV,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DIO1,DLL1,DNASE1L3,DUSP1,DUSP9,ECE1,EDN1,EDNRA,EGR3,ENDOD1,F2RL1,F3,FAM107A,FASN,FCER2,FCN1,FKBP5,FOS,FTL,GADD45B,GBP2,GBP4,GBP5,GBP7,GJB2,GLIS1,GLUL,GNAI2,GZMB,H6PD,HK2,HLA-DOB,HMOX1,IER3,IFI44,IFI44L,IFIT1,IFITM2,IFRD1,Igtp,IKBKE,IL12B,IL1A,IL22RA1,IL2RB,IL4R,IL6R,INHBA,IRAK2,IRF4,Irgm1,IRS1,ISG15,JAK3,JUNB,KDR,Klrk1,KRT17,KRT7,KYNU,LAG3,LAT2,LCN2,LGALS3,LIF,LIMK1,LOX,LTA,LTB,MAFF,MAP3K8,MERTK,MMP9,Mt1,MX1,Mx2,MYC,MYCN,NEDD9,NFKBIA,NR5A2,NRP1,NUPR1,OAS2,Oasl2,ODC1,P2RY14,PBK,PCK1,PCTP,PDGFB,PDHA1,PDK4,PFKFB3,PHACTR1,PLAUR,PPARA,PPARGC1B,PPP1R1B,PRF1,PTGS2,PTPRN,PTX3,RAB17,RAB20,RAD18,RGCC,RGN,RSAD2,S100A8,SDC4,SELE,SELL,SELP,SEMA7A,SERPINE1,SERPINH1,SHB,SIX1,SLC11A1,SLC16A3,SLC16A9,SLC28A1,SLC28A2,SLC6A6,SLC7A5,SMPD3,SOAT1,SOCS2,SOCS3,STAT1,TBX21,TGFBR3,TGM1,THBS1,TIMP1,TIMP3,TLR5,TMEM171,TNFAIP6,TNFRSF12A,TNFRSF14,TNFSF10,TP73,TREM3,TREML2,TRH,TRIL,TXNIP,USP18,WNT5A,XCL1,ZBTB16,ZEB2,ZFP36,ZNF81 | 522 (17) |
| EIF4EBP2 | -1.20e-01 | translation regulator | NA | -7.80e-01 | 1.0e-02 | CEBPD,CXCL10,IL12B,NFIL3,PNPLA2,PTGS2 | 391 (15) |
| DUSP1 | 1.14e+00 | phosphatase | NA | -7.90e-01 | 0.0e+00 | BMP2,CCL2,Ccl2,CCL4,CIDEA,CLEC10A,CMPK2,CXCL10,CXCL2,CXCL3,DUSP1,FOSL1,GJB2,IER3,IFI44,IFIT1,IFITM5,IL1A,IRF4,ISG15,MERTK,MX1,Mx2,NRP1,PDGFB,PEX11A,PLAT,PLAUR,PTGS2,RSAD2,SELE,SERPINE1,SOCS3,USP18,ZFP36 | 413 (17) |
| SLC16A2 | -1.00e-01 | transporter | NA | -7.90e-01 | 0.0e+00 | CIRBP,DIO1,Nrgn,RBM3,SEMA7A,SLC16A3,SLC7A5,SLCO1C1,TRH | 256 (11) |
| RARG | -3.20e-01 | ligand-dependent nuclear receptor | NA | -7.90e-01 | 0.0e+00 | ATP6V0A4,BMP2,CCL28,CYP26B1,DUSP1,FOS,FOXC1,GJB4,Meis1,MYC,SLC10A1,SOX2,UBA7 | 517 (23) |
| TEAD1 | -2.20e-01 | transcription regulator | NA | -7.90e-01 | 1.0e-02 | BBOX1,CDKN1A,CPT1B,EDN1,EDNRA,FABP3,FIBIN,FJX1,GPR37,KAZN,LOXL1,PPARA,PPARGC1B,PTGS2,PTPRO,TGFA,THBS1 | 425 (17) |
| NR0B2 | -9.20e-01 | ligand-dependent nuclear receptor | NA | -7.90e-01 | 0.0e+00 | ABCB11,BAAT,Ccl2,CD163,CDKN1A,CPT1A,CXCL10,CYP7B1,ESRRG,FASN,HDC,HNF4A,IL33,ISG15,LCK,LPIN1,MAP3K8,NR0B2,PCK1,PDK4,PPARA,SERPINE1,SLC10A1,TIMP1 | 438 (22) |
| methyl-beta-cyclodextrin | NA | chemical drug | NA | -7.90e-01 | 0.0e+00 | BCL2L1,CXCL2,CXCL3,MYC,SELE,SELP,SERPINE1,SOX2,TNFRSF8 | 333 (14) |
| APOE | -3.30e-01 | transporter | NA | -8.00e-01 | 0.0e+00 | ADAMTS5,ADGRE1,APOB,ATF3,ATF4,C3AR1,Ccl2,CCL4,CD40LG,CPT1A,CTSV,CXCL3,CXCL6,CYSLTR1,EDN1,F10,F2RL1,F3,FKBP5,FOS,GAS7,GLUL,HMOX1,HPCAL1,IL12B,IL1A,IL4R,IL6R,IRF4,JAK3,LCN2,LIMS2,MGP,MMP9,MYC,MYOCD,NELL2,PPARA,PPARGC1B,PRKCB,PTGS2,PTX3,S100A8,SDC4,SELE,SEMA6B,SERPINE1,SOCS3,STAT1,TIMP1,TNFRSF14,TXNIP | 535 (17) |
| TICAM2 | -1.90e-01 | other | NA | -8.00e-01 | 1.0e-02 | CCL4,CXCL10,IL12B,MMP8,S100A8 | NA |
| INHA | 3.80e-01 | growth factor | NA | -8.00e-01 | 0.0e+00 | ADAMTS1,ADAMTSL2,CYP26B1,DHH,DNAH2,EREG,FGFR4,HSD17B2,INHBA,MYC,PIK3IP1,PTGS2,PTX3,SERPINE1,SMARCA1 | 304 (12) |
| bromodeoxyuridine | NA | chemical drug | NA | -8.00e-01 | 0.0e+00 | BMP3,BMP7,CXCL10,F3,IFI44,IFIT1,IL1A,IL24,INHBA,IRF4,ISG15,MX1,SERPINE1,STAT1,TGFA,TNFSF10,TRH | 454 (20) |
| SCGB1A1 | -1.60e-01 | cytokine | NA | -8.10e-01 | 0.0e+00 | Ccl2,CDKN1A,MMP9,PTGS2,S100A8,SELL | 387 (14) |
| ANXA2 | 1.30e-01 | other | NA | -8.10e-01 | 0.0e+00 | CDKN1A,GADD45A,MYC,PLG,PTGS2,SESN1,SESN2 | 474 (23) |
| GJA1 | 1.20e-01 | transporter | NA | -8.10e-01 | 0.0e+00 | BMP2,CCL2,CD69,CDKN1A,GJB2,PTGS2,THBS1 | 401 (16) |
| acriflavine | NA | chemical toxicant | NA | -8.10e-01 | 0.0e+00 | ADORA2B,CD274,MYC,SOCS3 | 362 (10) |
| H89 | NA | chemical drug | NA | -8.10e-01 | 0.0e+00 | ADORA2A,BCL2L1,BMP2,BMP6,Ccl2,CCNA1,CD14,CD83,CDKN1A,COL2A1,CREB1,CREM,DUSP1,EGR3,EREG,EZH2,FOS,Gsta1,HMOX1,HSD11B2,JUNB,MMP9,MYC,NFIL3,NFKBIA,POU2AF1,PTGS2,S100A8,SERPINE1,TFPI2,TGFA,TNFAIP6 | 500 (17) |
| MEOX2 | -9.70e-01 | transcription regulator | NA | -8.20e-01 | 0.0e+00 | CCL2,CD69,CDKN1A,CXCL2,CXCL3,CXCL6,EDN1,F3,ID4,PTX3,SELE | 395 (14) |
| icilin | NA | chemical reagent | NA | -8.20e-01 | 0.0e+00 | Ccl2,CCL4,CXCL10,CXCL2,IL12B,IL1A | 206 (7) |
| DMD | NA | other | NA | -8.20e-01 | 2.0e-02 | ANKRD1,ARHGAP20,BTG2,CDKN1A,Cmya5,GRHL1,KCNN3,LIF,LPIN1,MAOB,MLF1,PDK4,PHKG1,PPP1R3C,SCIN,SCN1B,SERPINB1,UCK2,UNC79,WFDC1 | NA |
| EFNA3 | -5.00e-02 | kinase | NA | -8.20e-01 | 3.0e-02 | FOSL1,KRT7,KRT75,PKP1,PLAT,TGM1 | NA |
| TCOF1 | -1.60e-01 | transcription regulator | NA | -8.20e-01 | 5.0e-02 | ADAMTS1,ARL4D,FABP3,GPR55,KIF26B,MEOX1,PPP4R4,SOSTDC1,TBRG4,TXNRD1 | NA |
| CDH1 | 2.80e-01 | other | NA | -8.20e-01 | 0.0e+00 | BMP7,CCL17,ERBB3,FOSL1,GLI1,KRT7,LCN2,MCAM,MMP9,MYC,PFKFB3,PLAUR,TPBG | 482 (20) |
| Pam3-Cys-Ser-Lys4 | NA | chemical reagent | NA | -8.20e-01 | 0.0e+00 | ADGRE5,BCL2A1,BCL2L1,CCL17,CCL19,CCL2,Ccl2,CCL4,CD14,CD180,CD274,CD40LG,CD69,CD83,CXCL10,CXCL2,CXCL3,CXCL6,F2RL1,F3,GFI1,IER3,IL12B,IL1A,IRF4,ITGB7,LTB,MMP9,NFKBIA,PAX5,PTGS2,SELE,SELP,SERPINE1,SLC16A3,STAT1,TBX21,TNFRSF13C,TNFRSF14,Tnfsf9 | 272 (11) |
| OXT | 2.00e-02 | other | NA | -8.30e-01 | 1.0e-02 | ACTC1,CIDEA,CREB1,FASN,FOS,PTGS2 | 476 (24) |
| IL4R | 1.35e+00 | transmembrane receptor | NA | -8.40e-01 | 0.0e+00 | ABL1,ADGRL2,CCL17,Ccl2,CD14,CD69,CLCA1,CTTNBP2,CX3CR1,FCER2,GCSAM,MUC5B,SEZ6,SOCS3,SOX2,TBX21 | 384 (19) |
| miR-27a-3p (and other miRNAs w/seed UCACAGU) | NA | mature microRNA | NA | -8.40e-01 | 0.0e+00 | ADORA2B,CLDN5,EDNRA,FASN,HNF4A,ODC1,Pmaip1,PNPLA2,PNPLA3,THRB | NA |
| PDPK1 | -1.70e-01 | kinase | NA | -8.40e-01 | 3.0e-02 | CDKN1A,CXCL10,MYC,SELL,SERPINE1,SOX2 | NA |
| NME1 | 1.30e-01 | kinase | NA | -8.40e-01 | 3.0e-02 | CDKN1A,LPAR1,PTGS2,SERPINE1,SMO,TIMP1 | NA |
| IDR-1002 | NA | chemical reagent | NA | -8.40e-01 | 0.0e+00 | C3AR1,CCL2,Ccl2,CCL4,CSF3R,CXCL2,CXCL3,CXCL6,PTGIR,SLC11A1 | NA |
| SPIB | -2.80e-01 | transcription regulator | NA | -8.40e-01 | 0.0e+00 | ATF3,BMP6,CCL24,CCR9,CD300C,CLEC10A,COL2A1,DLL1,GEM,IKZF3,IRF4,KDR,LILRB3,P2RY10,Siglech | NA |
| IL12 (complex) | NA | complex | NA | -8.50e-01 | 0.0e+00 | ADGRE1,BCL2L1,CCL17,CCL19,CCL2,Ccl2,CCL4,CCR6,CD28,CD40LG,CD69,CXCL10,CXCL6,FOS,GADD45B,GADD45G,GZMA,GZMB,IL12B,IRF4,ISG15,KLRD1,LTA,LTB,MAP3K8,MMP9,MYC,PRF1,PTGS2,SELL,SELP,SOCS2,SOCS3,TBX21,TIMP1,XCL1 | 399 (18) |
| SERPINE2 | 2.60e-01 | other | NA | -8.50e-01 | 0.0e+00 | CCL17,CCL19,Ccl2,CCL4,CXCL10,CXCL3,GLI1,IL1A,LTA,LTB,MMP9,SELE | 418 (16) |
| IFNGR1 | 5.50e-01 | transmembrane receptor | NA | -8.50e-01 | 1.0e-02 | CCL17,Ccl2,CCL4,CCR10,CXCL10,CXCL3,CXCL6,GBP5,IL1A,IL1R2,IL6R,MMP9,MX1,PRKCG,TBX21,TRAF3IP3,UBC | NA |
| DENR | -2.30e-01 | other | NA | -8.50e-01 | 0.0e+00 | ABLIM1,CD274,CDKL5,STAT1 | NA |
| omeprazole | NA | chemical drug | NA | -8.50e-01 | 0.0e+00 | ADORA1,ADORA2A,BCL2L1,CDKN1A,CXCR4,FOS,HDC,POR,WFDC1 | 325 (13) |
| baclofen | NA | chemical drug | NA | -8.50e-01 | 0.0e+00 | BMP2,FOS,GNRH1,PER1 | 496 (21) |
| ilomastat | NA | chemical drug | NA | -8.50e-01 | 1.0e-02 | CCL2,Ccl2,CXCL10,CXCL3,MMP9 | 411 (18) |
| sulfasalazine | NA | chemical drug | NA | -8.50e-01 | 2.0e-02 | BCL2L1,GZMB,IER3,NFKBIA | NA |
| NFIA | -1.90e-01 | transcription regulator | NA | -8.50e-01 | 2.0e-02 | LOX,PCK1,PPARA,RGN,TNFSF18 | NA |
| TNFRSF11A | 3.30e-01 | transmembrane receptor | NA | -8.50e-01 | 3.0e-02 | BCL2L1,CCL19,IL12B,SOX2 | NA |
| 2,3 butanedione monoxime | NA | chemical drug | NA | -8.50e-01 | 3.0e-02 | ATP1A1,ATP2B4,KCNJ5,RYR2 | NA |
| GDF11 | -4.00e-02 | growth factor | NA | -8.50e-01 | 4.0e-02 | BMP2,BMP7,COL2A1,FOS,LPAR5,PDGFB,PTGS2,THBS1 | NA |
| SPRY1 | NA | other | NA | -8.50e-01 | 5.0e-02 | ISG15,LMO4,LOX,MYOCD | NA |
| Y 27632 | NA | chemical drug | NA | -8.50e-01 | 0.0e+00 | Acan,ANKRD1,BMP2,CCL2,Ccl2,CDKN1A,CLDN5,COL2A1,CXCL10,CXCL2,FOS,MMP9,MYC,MYOCD,PTGS2,SERPINE1,THBS1 | 477 (21) |
| minocycline | NA | chemical drug | NA | -8.50e-01 | 0.0e+00 | ADGRE1,ATF3,BCL2L1,Ccl2,CD163,FOS,IL1A,IL6R,KCNA3,NGFR,PDGFB,PTGS2 | 482 (15) |
| poly(dG-dC) | NA | chemical reagent | NA | -8.50e-01 | 0.0e+00 | CXCL10,ISG15,RSAD2,STAT1 | 227 (12) |
| PEBP1 | 1.30e-01 | other | NA | -8.50e-01 | 0.0e+00 | BCL2L1,Ccl2,CIDEA,CXCL2,CXCL3,FASN,PCK1,PON1,RBP4 | 390 (15) |
| SOX2 | -1.23e+00 | transcription regulator | NA | -8.60e-01 | 0.0e+00 | ADAMTS4,ADORA2A,AFAP1L2,ALB,APCDD1,ATF3,BCL2L1,BHLHE40,BMP6,BMPER,CD274,CDKN1A,CHST3,CLDN11,CXCL10,CXCL3,CXCR4,DLL1,DUSP1,Elf5,EPHA2,FGFR4,FOS,GAB2,GADD45B,GBP4,GLI1,INHBA,IRS1,KDR,KRT17,KRT7,LIMS2,LPAR1,Meis1,MYC,MYCN,Nes,NR5A2,NRP1,Oasl2,PPARA,PPL,PRKCH,PSAT1,S1PR5,SERPINE1,SOSTDC1,SOX2,TBX6,TET1,TGM1,TIMP3,TNFRSF14,TNFRSF19,TXNRD1,USP18,WNT5A | 491 (27) |
| pimagedine | NA | chemical drug | NA | -8.60e-01 | 0.0e+00 | ALB,BCL2L1,CRP,GADD45B,HMOX1,POU2F2,SERPINE1,TNFSF10 | 516 (22) |
| phytohemagglutinin | NA | chemical drug | NA | -8.60e-01 | 0.0e+00 | AFF1,CAP2,CCL2,CCL4,CD69,CD83,CLCN4,CXCL10,CXCR4,FOS,FOSL2,GAB2,GCLC,GNRH1,GPR55,GZMB,IKZF3,IL1R2,IL21R,IL24,ITIH4,JAK3,KCNMB1,LTA,MAOA,MMP9,PAX5,PEMT,PGF,PLCD1,PRF1,PTGER3,PTPRC,SPHK1,STAT1,TBX21,TIMP1,TIMP3,TNFSF10,XCL1 | 405 (17) |
| AGTR1 | 3.30e-01 | G-protein coupled receptor | NA | -8.70e-01 | 0.0e+00 | DUSP1,EDN1,FOS,HMOX1,PTGS2,SERPINE1,TXNIP,XDH | 478 (18) |
| advanced glycation end-products | NA | chemical - endogenous mammalian | NA | -8.70e-01 | 2.0e-02 | CCL2,CDKN1A,CLDN5,MMP9,PDGFB,PTGS2,SERPINE1 | NA |
| THRA | -4.00e-02 | ligand-dependent nuclear receptor | NA | -8.80e-01 | 0.0e+00 | ATF4,CCL17,CCL2,Ccl2,CCL28,CDKN1A,CIRBP,CPT1A,CTSH,CXCL10,CXCL2,CXCL3,DIO1,FASN,FOS,FZD9,GHRHR,HEPACAM,HMOX1,IL1A,INHBA,Nrgn,PCK1,Pln,POR,SERPINE1,SLC6A12,THRB,TRH | 495 (24) |
| PD184352 | NA | chemical drug | NA | -8.80e-01 | 4.0e-02 | BCL2L1,CXCL3,FOS,TP73 | NA |
| ELAVL1 | -4.60e-01 | other | NA | -8.90e-01 | 0.0e+00 | ANKRD1,ARG2,ATF3,BCL2L1,CD83,CDKN1A,Csprs (includes others),DUSP1,F830016B08Rik,FOS,HMOX1,IFI44,IL1R2,IRF4,Irgm1,MYC,NFKBIA,OAS2,PBK,PTGS2,PTPRC,SAT1,SLC7A7,STAT1,TBX21,USP18,WNT5A,ZFP36 | 475 (20) |
| NOX1 | 3.30e-01 | enzyme | NA | -8.90e-01 | 0.0e+00 | F3,HMOX1,KDR,MMP9,NFKBIA,TGFA | 390 (15) |
| PARP1 | -1.80e-01 | enzyme | NA | -8.90e-01 | 0.0e+00 | Ccl2,CCL4,CCR6,CD274,CD83,CDKN1A,CXCL10,CXCL3,ECE1,FASN,FOS,GBP2,GBP4,GBP7,HMOX1,Igtp,IL12B,LIF,MMP9,MYC,NELL2,PTGS2,RAPGEF4,SELP,SFTPB,SLC38A2,SOCS2,STAT1,TBX21,TGFA,TIMP1,XCL1 | 488 (19) |
| GPBAR1 | NA | G-protein coupled receptor | NA | -9.00e-01 | 1.0e-02 | ADGRE1,Ccl2,DIO2,GCLC,LIMK1,PPARA,SELE | 315 (7) |
| I-BET-151 | NA | chemical reagent | NA | -9.00e-01 | 3.0e-02 | CXCL2,CXCL3,CXCL6,MYCN,TRERF1,UCK2 | NA |
| PD173074 | NA | chemical reagent | NA | -9.00e-01 | 0.0e+00 | BCL2L1,CR2,F3,GABRP,KRT7,LTB,MYC,NUPR1,PGF,PRKCH,SLC13A4,SLC38A3,SPNS2 | 392 (16) |
| Hsp90 | NA | group | NA | -9.00e-01 | 0.0e+00 | AR,BCL2L1,CD28,CD40LG,CD69,CIITA,ERBB3,KCNJ11,KLRD1,LCK,MYC,ZFAND2A | 535 (22) |
| PI3K (family) | NA | group | NA | -9.00e-01 | 0.0e+00 | CCL2,CD274,CXCL10,CXCR4,DDIT4,FASN,FOS,GCLC,GLI1,HMOX1,IFIT1,IL12B,ISG15,MMP9,MYC,PDGFB,PTGS2,SERPINE1,THBS1,TNFSF10,TP73,TXNIP | 466 (17) |
| alitretinoin | NA | chemical drug | NA | -9.00e-01 | 0.0e+00 | ABCB11,ADAMTS4,ANGPTL3,AR,BCL2A1,BCL2L1,BMP3,BMP7,CCL24,CD14,CD5L,CD83,CDKN1A,CIDEA,CPT1B,CXCL10,DNASE1L3,DUSP1,FASN,FOS,GHRHR,HNF4A,IL2RB,ISG15,MMP9,NR0B2,PGLYRP1,PPARA,SFTPB,SOAT1,UBA7 | 517 (21) |
| miR-17-5p (and other miRNAs w/seed AAAGUGC) | NA | mature microRNA | NA | -9.00e-01 | 0.0e+00 | ADAMTS5,BMP2,C1QTNF1,Ccl2,CD274,CDKN1A,CREB1,HSF2BP,IRAK2,KRT17,KRT81,PPARA,TP73,TXNIP | NA |
| LPL | 4.40e-01 | enzyme | NA | -9.10e-01 | 0.0e+00 | APOB,CCL2,CPT1A,FABP3,IRS1,PDK4,PNPLA2,PPARA,SELE,THBS1,TIMP1 | 518 (24) |
| RIGI | NA | enzyme | NA | -9.10e-01 | 0.0e+00 | BLK,CCL2,Ccl2,CCL4,CD83,CX3CR1,CXCL10,DLL1,GEM,IFI44,IFIT1,IL1A,IL4R,IRAK2,ISG15,JAK3,MX1,PLAUR,Pmaip1,PTGS2,RSAD2,SLC11A1,SOCS3,STAT1,TBX21,THBS1,TLR5,TNFRSF18,TNFSF10,UBA7,USP18 | 309 (17) |
| MSI2 | 3.30e-01 | other | NA | -9.20e-01 | 2.0e-02 | CDKN1A,CLDN5,MYC,SOX2 | NA |
| MXI1 | 7.00e-02 | transcription regulator | NA | -9.20e-01 | 2.0e-02 | MYC,MYCN,ODC1,SLC7A1 | NA |
| CpG ODN 1826 | NA | chemical reagent | NA | -9.20e-01 | 0.0e+00 | ADRA1A,CCL2,CCL4,CD14,CD274,CD69,CD83,CIITA,CXCL10,CXCL3,IL12B,IL1A,OAS2,Oasl2,Tnfsf9,TRPV1,XCL1 | 313 (19) |
| IL5 | NA | cytokine | NA | -9.20e-01 | 0.0e+00 | AOC1,ATF4,ATP1B1,BCL2L1,CA4,CCL2,CCR3,CCR9,CD40LG,CD69,CD79A,CDKN1A,CIITA,CRELD2,CSF3R,CX3CR1,CXCR4,CYSLTR1,EGR3,FOSL2,GADD45A,GADD45G,GBP2,GBP4,GBP7,IER3,IL1R2,IL4R,IL6R,ITGAD,ITGB7,LTA,LTB,MMD,MMP9,MYC,NFIL3,P4HA1,PAX5,PSAT1,PTPRC,RBM3,SFPQ,SLC16A3,SLC7A5,SNAP23,SNTB1,SOCS2,SPN,TNFRSF8,TNFSF8,TRA2A,UCK2,UPP1 | 540 (20) |
| WWTR1 | -1.00e-02 | transcription regulator | NA | -9.20e-01 | 0.0e+00 | ADGRG5,BMP2,CCR10,CD3G,CDKN1A,CXCL2,CXCL3,CXCL6,EXOC3L2,FASN,IL1A,IL24,INHBA,KDR,KRT17,LAMA5,MX1,PRMT8,SERPINE1,STAT1,TNFRSF8,WDR49 | 352 (21) |
| CTBP1 | -1.10e-01 | enzyme | NA | -9.30e-01 | 0.0e+00 | BMP7,CDKN1A,CLDN11,CYP26B1,ENC1,FKBP5,FOS,MMD,THBS1 | NA |
| COL1A1 | -3.80e-01 | other | NA | -9.30e-01 | 0.0e+00 | CCL2,CDKN1A,CXCR4,EDN1,SELE | 357 (12) |
| flutamide | NA | chemical drug | NA | -9.30e-01 | 4.0e-02 | AR,Ccl2,Chn1,CXCL2,DHH,FOS,KDR,ODC1,Slco1a1,Tsx | NA |
| MMP14 | 2.10e-01 | peptidase | NA | -9.30e-01 | 4.0e-02 | ATF3,CDKN1A,IL12B,PTGS2,SMARCA1 | NA |
| CCL3 | NA | cytokine | NA | -9.30e-01 | 0.0e+00 | CCL2,CCL4,FOS,RYR2,SELE,STAT1 | 331 (20) |
| docosahexaenoic acid | NA | chemical drug | NA | -9.30e-01 | 0.0e+00 | ATF4,BCL2A1,BCL2L1,CCL2,Ccl2,CCL4,CD83,CDKN1A,CPT1A,CXCR4,ERN1,FASN,FOS,HK2,HMOX1,IL12B,LOX,LOXL1,MMP9,MYC,PCK1,PLAT,PNPLA2,PPARA,PTGS2,SELE,SERPINE1,SERPINH1,SOCS3,SPHK1,THBS1,TIMP1 | 482 (21) |
| aphidicolin | NA | chemical toxicant | NA | -9.30e-01 | 0.0e+00 | CDKN1A,GADD45A,IFI44L,IFIT1,MX1,STAT1,TP73 | 493 (22) |
| miR-26a-5p (and other miRNAs w/seed UCAAGUA) | NA | mature microRNA | NA | -9.40e-01 | 0.0e+00 | CDKN1A,CHORDC1,CXCL3,EPHA2,EZH2,MYC,PTGS2 | 227 (7) |
| nicardipine | NA | chemical drug | NA | -9.40e-01 | 0.0e+00 | CXCL2,CXCL3,Cyp4a14,SELE,SELP | 234 (9) |
| mir-34 | NA | microRNA | NA | -9.40e-01 | 0.0e+00 | AR,CCDC113,CREB1,CXCL3,DLL1,DNAH6,FOSL1,HK2,ITGA2B,KCNH1,MYC,MYCN,PFKFB3,REM2,SLC30A3,TIMP3 | 514 (20) |
| fisetin | NA | chemical drug | NA | -9.40e-01 | 0.0e+00 | BCL2L1,Ccl2,FOS,IL12B,MMP9,MYC,NFKBIA,PCK1,PTGS2 | 391 (15) |
| CIP2A | NA | other | NA | -9.40e-01 | 0.0e+00 | ENO3,GADD45A,GPR37,HK2,IER3,MYC,PDK4,PLAUR,SAT1,SCIN,SLC16A3 | 447 (16) |
| IKK (complex) | NA | complex | NA | -9.40e-01 | 0.0e+00 | BCL2L1,CXCL10,FANCG,MMP9,MYC,PTGS2,TBX21 | 379 (17) |
| nimesulide | NA | chemical drug | NA | -9.40e-01 | 1.0e-02 | EDNRA,EREG,MMP9,PTGS2 | NA |
| SMYD3 | NA | enzyme | NA | -9.50e-01 | 0.0e+00 | AR,CCNA1,CEBPD,NKX2-8,PSMD9,RASSF1 | NA |
| LRP6 | 1.20e-01 | transmembrane receptor | NA | -9.50e-01 | 0.0e+00 | Ccl2,CXCL2,CXCL3,FOS,HK2,IL1A,MMP9,MYC,PNPLA3 | 437 (22) |
| KDM8 | 3.00e-02 | enzyme | NA | -9.50e-01 | 2.0e-02 | CCNA1,ENO3,EZH2,FASN,HK2,OSR2,PDHA1,PDK4,WNT5A | NA |
| MAT2A | -5.00e-02 | enzyme | NA | -9.60e-01 | 0.0e+00 | FOS,HMOX1,LAG3,MMP9 | NA |
| KDM2B | -5.00e-02 | enzyme | NA | -9.60e-01 | 0.0e+00 | Ccl2,CDKN1A,COL2A1,CXCL10,EZH2,FOS,LAMA5,SOX7 | 479 (24) |
| choline fenofibrate | NA | chemical drug | NA | -9.60e-01 | 0.0e+00 | CPT1A,F3,NFKBIA,NPC2,PON1,PPARA,SERPINE1 | 526 (20) |
| thalidomide | NA | chemical drug | NA | -9.70e-01 | 0.0e+00 | BCL2L1,FOS,GADD45B,KDR,NRP1,PDGFB,PLAUR,SERPINE1 | 546 (18) |
| LRP5 | 7.00e-02 | transmembrane receptor | NA | -9.70e-01 | 2.0e-02 | Ccl2,CXCL2,CXCL3,HNF4A,IL1A,IRS1,NKD2 | NA |
| LY6E | 1.70e-01 | other | NA | -9.70e-01 | 0.0e+00 | CD14,CD274,CD83,IRAK2,NFKBIA,SERPINE1 | NA |
| 3-nitropropionic acid | NA | chemical toxicant | NA | -9.70e-01 | 3.0e-02 | ATP1B1,BCL2L1,GCLC,MMP9,MYC,NGFR,PPP1R1B | NA |
| betulinic acid | NA | chemical drug | NA | -9.70e-01 | 0.0e+00 | AR,BCL2L1,FASN,MMP9,PTGS2,SELP,TIMP1 | 451 (19) |
| mir-22 | NA | microRNA | NA | -9.70e-01 | 1.0e-02 | BMP6,BMP7,CDKN1A,ERBB3,FOSL1,FRAT2,HK2 | 414 (17) |
| IFI16 | 4.00e-02 | transcription regulator | NA | -9.80e-01 | 0.0e+00 | CCL2,CCL4,CD28,CDKN1A,CSF3R,CXCL10,EDN1,GADD45A,IL2RB,ISG15,MYC,NFKBIA,SELE | 484 (13) |
| GRN | 2.00e-01 | growth factor | NA | -9.80e-01 | 0.0e+00 | Acan,ADAMTS5,CCL2,Ccl2,CCL4,CD14,COL2A1,CX3CR1,CXCL2,IL12B,LGALS3,MERTK,NPC2,SOAT1,TXNIP | 527 (19) |
| ursolic acid | NA | chemical drug | NA | -9.90e-01 | 0.0e+00 | ATF3,BCL2L1,CD69,CDKN1A,CLDN11,CXCR4,FASN,FOS,HK2,MMP9,MYC,PTGS2,S1PR5,SLC38A2 | 434 (17) |
| DEF6 | -5.00e-02 | other | NA | -9.90e-01 | 3.0e-02 | FOS,IL12B,MMP9,ZEB2 | NA |
| eplerenone | NA | chemical drug | NA | -9.90e-01 | 0.0e+00 | Ccl2,EDN1,EDN3,LGALS3,MMP9,PTGS2,SERPINE1 | 539 (21) |
| HOTAIR | NA | other | NA | -9.90e-01 | 3.0e-02 | CDKN1A,CEBPD,MMP9,MX1,MYC,NFKBIA,SOX2 | NA |
| RIPK2 | -4.00e-02 | kinase | NA | -9.90e-01 | 0.0e+00 | Ccl2,CD69,CMPK2,CXCL10,CXCL2,CXCL3,CXCL6,FASN,GBP4,IFI44,IFI44L,IFIT1,IKBKE,IL1A,IL33,ISG15,LMO4,MAP3K6,MX1,MYC,MYCN,NFKBIA,OAS2,PNPLA2,PPARA,RASGRP1,RSAD2,SELE,STAT1,TNFAIP6,TNFRSF18,TNFSF10,TRIM14,USP18,ZBP1 | 448 (18) |
| HDAC4 | 5.00e-01 | transcription regulator | NA | -9.90e-01 | 0.0e+00 | ATF3,CAP2,CDKL5,CDKN1A,DRP2,FOS,FOSL1,GADD45A,ISG15,LGI1,MMP9,Pcp4l1,Pln,PPM1E,PRKCB,PTGS2,RSAD2,TNFRSF12A,TRPV1 | 453 (23) |
| ETV5 | -2.00e-02 | transcription regulator | NA | -1.00e+00 | 0.0e+00 | Ccl2,CD14,CDKN1A,CLDN4,CXCR4,FASN,GALNT3,KRT7,KRT80,LCN2,LGALS3,LGI3,MLC1,NFKBIA,PLAUR,SFTPB,SOAT1,TIMP3,TINAGL1 | 324 (13) |
| PPT1 | 4.00e-02 | enzyme | NA | -1.00e+00 | 0.0e+00 | Ccl2,CCL4,CXCL10,CXCL3 | NA |
| zeranol | NA | chemical - endogenous mammalian | NA | -1.00e+00 | 0.0e+00 | AR,BCL2L1,HMOX1,MAOA,MYC | 307 (7) |
| H3-3A/H3-3B | -2.10e-01 | other | NA | -1.00e+00 | 0.0e+00 | CD79A,CDKN1A,Meis1,MYCN,PROCR | NA |
| DGAT1 | 9.00e-02 | enzyme | NA | -1.00e+00 | 0.0e+00 | CPT1A,CPT1B,PDK4,PNPLA2,PPARA | 515 (25) |
| tiron | NA | chemical reagent | NA | -1.00e+00 | 0.0e+00 | CDKN1A,DUSP1,HMOX1,PLAUR | 379 (17) |
| ANLN | 4.40e-01 | other | NA | -1.00e+00 | 0.0e+00 | ACER2,BTG2,CDKN1A,CYP26B1,HSPA4L,PHLDB3,SESN1,SESN2,TCEA3 | NA |
| SART1 | 2.60e-01 | other | NA | -1.00e+00 | 0.0e+00 | DDIT4,MMP9,SERPINE1,SOX2 | 311 (7) |
| ENTPD1 | 6.00e-02 | enzyme | NA | -1.00e+00 | 0.0e+00 | CXCL2,CXCL3,IL12B,SERPINE1 | 410 (17) |
| lamivudine | NA | chemical drug | NA | -1.00e+00 | 0.0e+00 | EREG,IFI44L,LCN2,SERPINE1 | NA |
| NFAT (complex) | NA | complex | NA | -1.00e+00 | 0.0e+00 | ATF3,CCL2,CD40LG,F3,IL33,SERPINE1 | NA |
| gossypin | NA | chemical - endogenous non-mammalian | NA | -1.00e+00 | 0.0e+00 | BCL2L1,MMP9,MYC,PTGS2 | 372 (13) |
| isoleucine | NA | chemical - endogenous mammalian | NA | -1.00e+00 | 0.0e+00 | Ccl2,CDKN1A,CXCL2,CXCL3 | 254 (10) |
| clorgyline | NA | chemical drug | NA | -1.00e+00 | 0.0e+00 | CCL2,CEBPD,MYC,SOCS3 | 383 (13) |
| tetrathiomolybdate | NA | chemical drug | NA | -1.00e+00 | 0.0e+00 | IL1A,MMP9,SERPINE1,TIMP1 | 527 (15) |
| ACTL6A | 1.30e-01 | other | NA | -1.00e+00 | 0.0e+00 | BCL2L1,CDKN1A,HMOX1,MYC,SFN,TBX21 | 455 (15) |
| gambogic acid | NA | chemical - endogenous non-mammalian | NA | -1.00e+00 | 0.0e+00 | BCL2L1,MMP9,MYC,PTGS2 | 427 (19) |
| N(2)-(gamma-D-glutamyl)-meso-2,2’-diaminopimelic acid | NA | chemical reagent | NA | -1.00e+00 | 1.0e-02 | Ccl2,CCL4,IL1A,MMP9 | 379 (15) |
| RPL13A | 1.30e-01 | other | NA | -1.00e+00 | 1.0e-02 | Ccl2,CDKN1A,LCN2,S100A8 | 338 (10) |
| echinomycin | NA | chemical drug | NA | -1.00e+00 | 1.0e-02 | ADAMTS1,CXCR4,HK2,IL1A | 429 (15) |
| EHHADH | 2.20e-01 | enzyme | NA | -1.00e+00 | 1.0e-02 | Cyp4a14,FASN,PDK4,PEX11A | 244 (7) |
| GRIN1 | 1.20e-01 | ion channel | NA | -1.00e+00 | 1.0e-02 | ATF3,EGR3,GAL,LOX,MMP16,SERPINE1,SMIM3,TMC5,XDH | NA |
| AQP1 | 1.12e+00 | transporter | NA | -1.00e+00 | 1.0e-02 | HSPA4L,LCN2,NUPR1,TGFA | NA |
| BHLHA15 | -1.20e-01 | transcription regulator | NA | -1.00e+00 | 1.0e-02 | ARRDC3,GJB1,GJB2,NUPR1 | NA |
| SIN3A | 1.60e-01 | transcription regulator | NA | -1.00e+00 | 2.0e-02 | CD274,EPGN,GADD45B,MMP9,MYC,PTGS2,SERPINE1,TXNIP | NA |
| edaravone | NA | chemical drug | NA | -1.00e+00 | 2.0e-02 | CCL2,Ccl2,CXCL3,FASN | NA |
| selenomethylselenocysteine | NA | chemical - endogenous mammalian | NA | -1.00e+00 | 3.0e-02 | ATP1A1,CXCL3,PLAUR,TIMP3 | NA |
| SOCS2 | 8.60e-01 | other | NA | -1.00e+00 | 4.0e-02 | CCL4,CD83,CXCL10,FASN | NA |
| alpha-tocopherol | NA | chemical drug | NA | -1.00e+00 | 5.0e-02 | ALB,CXCL3,HMOX1,IL1A | NA |
| ITGB2 | 1.00e-02 | transmembrane receptor | NA | -1.01e+00 | 0.0e+00 | BCL2A1,BCL2L1,Ccl2,CCL4,CD69,CXCL10,CXCL2,CXCL3,GADD45B,IL12B,MMP9,PTGS2,TBX21 | 379 (21) |
| HLX | -4.00e-02 | transcription regulator | NA | -1.02e+00 | 1.0e-02 | ANKRD1,BMP2,IL4R,KYNU,MYC,PLXNA1 | NA |
| KEAP1 | 1.20e-01 | transcription regulator | NA | -1.02e+00 | 2.0e-02 | GCLC,GNAI2,HMOX1,MAP1LC3B,MMP9,SELP | NA |
| melatonin | NA | chemical - endogenous mammalian | NA | -1.02e+00 | 0.0e+00 | AR,BCL2L1,BMP2,CCL2,Ccl2,CDKN1A,CRY2,CXCL10,CXCL2,CXCL6,DIO2,ECE1,EDN1,FASN,FOS,GJB2,GNRH1,HMOX1,IL2RB,IRS1,JUNB,MAP1LC3B,MMP9,Mt1,MYC,PLAT,PTGS2,SELE,SELP | 376 (15) |
| ERBB4 | -4.30e-01 | kinase | NA | -1.03e+00 | 0.0e+00 | BTG2,CCL2,CDKN1A,DUSP1,GADD45A,HMOX1,MYC,PTGS2,SOCS3,THBS1,TIMP3,WNT7A | 453 (20) |
| daidzein | NA | chemical drug | NA | -1.03e+00 | 1.0e-02 | CCL2,DNASE1L3,FCMR,HMOX1,KLRD1,LY86,MAP4K1,MYC,OSBPL3,PTGS2,RASGRP1,ZEB2 | 449 (20) |
| Sik1 | 1.35e+00 | kinase | NA | -1.03e+00 | 0.0e+00 | CREM,DIO2,DUSP1,FASN | 204 (7) |
| PF-4878691 | NA | chemical drug | NA | -1.03e+00 | 0.0e+00 | BCL2L1,CCL2,CCL4,CD83,CXCL10,IL12B,ISG15,MX1,MYC,PTGS2,STAT1 | 158 (7) |
| TCF4 | 3.00e-01 | transcription regulator | NA | -1.03e+00 | 1.0e-02 | ADAMTS9,APCS,ARHGAP4,BHLHE40,BMP7,CCL28,CDKN1A,CREB1,CRELD2,CREM,CSF3R,CSRNP1,DACH1,EDEM1,GIMAP4,GPR37,GRB14,IL12B,INHBA,NEDD9,NGFR,PIK3C2B,PTGS2,SELL,SERPINB1,SOCS3,TNFSF10,TXNIP,ZBP1,ZEB2 | NA |
| mifepristone | NA | chemical drug | NA | -1.04e+00 | 0.0e+00 | ABCB1,ABCB11,ABCC2,Acan,Acot1,AGR2,AQP1,AR,ATF3,BCL2L1,BMP7,CCL2,Ccl2,CD14,CD274,CDKN1A,CEBPD,CKMT1A/CKMT1B,COL2A1,DDIT4,DIO2,DUSP1,ERRFI1,F3,FKBP5,FOS,GAL,H6PD,HDC,IL12B,IL4R,JAK3,JUNB,LAMA5,LOX,MAP4K1,MMP9,Mt1,MYC,NFKBIA,NRTN,PFKFB3,PGLYRP1,PLAT,PTGS2,PTX3,RAMP3,RFX2,SERPINE1,SLC6A2,SPEG,TIMP1,TIMP3,TNFAIP6 | 581 (19) |
| SNHG20 | NA | other | NA | -1.04e+00 | 0.0e+00 | CCNA1,CDKN1A,MYC,ZEB2 | NA |
| VEGFB | 4.00e-02 | growth factor | NA | -1.04e+00 | 0.0e+00 | Acot1,ATF3,CA4,CIDEA,DIO2,IRF4,PDK4,Pmaip1,TXNRD1 | NA |
| resatorvid | NA | chemical drug | NA | -1.04e+00 | 1.0e-02 | CCL2,Ccl2,CXCL3,HK2,LYVE1,MMP9,PTGS2 | 347 (17) |
| bisindolylmaleimide I | NA | chemical drug | NA | -1.04e+00 | 0.0e+00 | AQP3,BCL2A1,BCL2L1,CDKN1A,FOS,HMOX1,KCNJ11,MMP9,Mt1,NFKBIA,POU2F2,PTGS2,SERPINE1,TNFSF10 | 390 (16) |
| S100A9 | -5.00e-01 | other | NA | -1.04e+00 | 0.0e+00 | ADAMTS1,ADAMTS4,ADAMTS5,ATF3,BHLHE40,Ccl2,CD27,CD274,CD69,CXCL10,CXCL3,DDIT4,FOSL1,GJB2,GZMB,IL33,ISG15,KLF15,MMP9,MRO,MYC,MYCT1,NGFR,NTRK3,PER1,PIK3IP1,PTPRO,RAB20,RBFOX1,RNASE6,S100A8,SDCBP2,SIX1,SLC26A1,SLC6A12,SOCS3,Spry1,TXNIP,USP18 | 356 (19) |
| honokiol | NA | chemical - endogenous non-mammalian | NA | -1.04e+00 | 0.0e+00 | BCL2L1,CDKN1A,FOS,JUNB,KDR,MAP1LC3B,MAP3K8,MMP9,PTGS2 | 314 (13) |
| FOXF1 | 2.00e-01 | transcription regulator | NA | -1.04e+00 | 3.0e-02 | CDKN1A,ERRFI1,KDR,PDGFB,WNT5A | NA |
| PF4 | 3.30e-01 | cytokine | NA | -1.05e+00 | 0.0e+00 | CCL2,CCL4,CD83,CDKN1A,CMPK2,CXCL3,F3,IL12B,IL1A,INHBA,ISG15,MYCN,NFKBIA,RSAD2,SOX2,SPHK1,STAT1,USP18 | 487 (17) |
| IL2 | NA | cytokine | NA | -1.06e+00 | 0.0e+00 | ARHGAP20,ARNT2,BCL2A1,BCL2L1,BHLHE40,BMP2,CBLB,CCL17,CCL2,Ccl2,CCL4,CCR3,CCR6,CCR9,CD274,CD28,CD3G,CD40LG,CD69,CD83,CD8A,CDKN1A,CREB1,CSRNP1,CTSW,CX3CR1,CXCL10,CXCL3,CXCR4,CYSLTR1,DDIT4,DPYSL5,DUSP1,EDN1,EPHA4,FCMR,FOS,FOSL2,GADD45B,GADD45G,GBP2,GEM,GFI1,GZMA,GZMB,HK2,IER3,IFRD1,IKZF3,IL12B,IL1A,IL1R2,IL24,IL2RB,IL4R,IRF4,ISG15,ITGB7,JAK3,JUNB,KCNA2,KCNG1,KCNK1,KLRD1,LAMA5,LCK,LGALS12,LIF,LRRC32,LTA,LTB,MAP2K6,MAPKAPK3,MMD,MMP9,MX1,MYC,Nrgn,NRP1,ODC1,OSBPL3,PAX5,PDE4A,PPP2R2B,PRF1,PSAT1,PTGIR,PTGS2,PTPRC,RAMP3,RCN1,RGCC,RGS16,S100A8,SELL,SELP,SERPINE1,SESN1,Sik1,SLC7A5,SNAP23,SOCS2,SOCS3,STK17B,SYTL2,TBX21,TGFBR3,TIMP1,TNFRSF12A,TNFRSF13C,TNFRSF18,TNFRSF21,TNFRSF8,TNFSF10,UCK2,UPP1,XCL1,ZDHHC23 | 383 (15) |
| fingolimod | NA | chemical drug | NA | -1.06e+00 | 0.0e+00 | BCL2L1,CCL17,CCL2,Ccl2,CCL4,CD274,CD69,CDKN1A,CXCL10,CXCL2,FASN,FOSL1,SERPINE1,SPHK1,TBX21 | 483 (20) |
| EPCAM | 3.40e-01 | other | NA | -1.06e+00 | 0.0e+00 | ADGRE1,ATF3,Ccl2,CDKN1A,CXCL3,FOS,FOSL1,MMP8,MYC,SOX2 | 460 (20) |
| MAP2K3 | 3.90e-01 | kinase | NA | -1.07e+00 | 0.0e+00 | ARG2,CDKN1A,CXCL10,IL12B,ISG15,MAOB,MMP9,MUC5B,Pln,PTGS2,SERPINE1,STAT1,TNFSF10 | 459 (19) |
| AURK | NA | group | NA | -1.07e+00 | 0.0e+00 | ACER2,BTG2,CDKN1A,CYP26B1,HSPA4L,PHLDB3,SESN1,SESN2,TCEA3 | NA |
| cytochalasin B | NA | chemical toxicant | NA | -1.07e+00 | 0.0e+00 | BMP2,CDKN1A,MCAM,MMP9,SELP | 400 (14) |
| anacardic acid | NA | chemical - endogenous non-mammalian | NA | -1.07e+00 | 0.0e+00 | AR,EDN1,IL33,MMP9,PLAT | 454 (18) |
| astressin 2B | NA | biologic drug | NA | -1.07e+00 | 0.0e+00 | Ccl2,CXCL2,FOS,KCNMB1 | 360 (11) |
| CD47 | 3.00e-02 | transmembrane receptor | NA | -1.07e+00 | 0.0e+00 | CCL19,FCER2,FTL,IL12B,KDR,MYC | 531 (18) |
| mir-379 | NA | microRNA | NA | -1.07e+00 | 1.0e-02 | BMP2,BMP6,PTPRN,TXNIP | NA |
| GABBR1 | 1.00e-02 | G-protein coupled receptor | NA | -1.07e+00 | 2.0e-02 | Acan,ATF4,BMP2,COL2A1 | NA |
| SOX17 | 4.10e-01 | transcription regulator | NA | -1.07e+00 | 4.0e-02 | FOS,HNF4A,KDR,SOX2,SOX7 | NA |
| GHRH | NA | other | NA | -1.07e+00 | 4.0e-02 | FOS,GHRHR,RAPGEF3,TRIM63 | NA |
| MSC | -3.00e-02 | transcription regulator | NA | -1.07e+00 | 0.0e+00 | ASB2,BMP7,CCL2,CCL28,CCL4,CD19,CD79A,IFI44,IFI44L,IFIT1,LGALS12,PAX5,POU2F2,SELL,TRIB1,XCL1 | 99 (5) |
| PDLIM2 | 2.90e-01 | other | NA | -1.07e+00 | 0.0e+00 | CEMIP,CLCN4,CRISPLD2,F2RL1,HLA-DOB,IFI44,KYNU,NPR3,PRR16,PRUNE2,SLC43A3,SRGAP1,STAT1,TXNIP | NA |
| Ifn | NA | group | NA | -1.07e+00 | 0.0e+00 | ADAMTS1,CD69,CD83,CXCL10,EDN1,FOS,IFIT1,IL12B,IL33,ISG15,LCN2,MMP9,MX1,Mx2,OAS2,RSAD2,S100A8,SERPINE1,STAT1,TLR5,XDH,ZBP1 | 354 (15) |
| L-methionine | NA | chemical - endogenous mammalian | NA | -1.07e+00 | 0.0e+00 | ALB,ATF4,AURKB,CXCL2,DDIT4,F3,GADD45B,NFKBIA,PCK1,PLAT,PTGS2 | 467 (20) |
| ESRRA | NA | transcription regulator | NA | -1.08e+00 | 0.0e+00 | ACTC1,APOLD1,C3AR1,CCL28,CPT1B,CTSH,CX3CR1,CXCL10,CXCR4,DYSF,EGR3,EPHA2,FABP3,FASN,FRAT2,GPR37,HK2,HMOX1,IKZF3,KCNJ11,MAOB,MMP9,NEXN,NR0B2,NRP1,PDK4,Pln,PLXND1,PPARA,PPARGC1B,PPP1R1B,PPP2R2B,RYR2,SHB,TNFRSF12A,TNS4,WNT11,ZC3H12A | 407 (17) |
| nifedipine | NA | chemical drug | NA | -1.08e+00 | 0.0e+00 | ABCB1,ATP2B3,ATP2B4,BMP2,CCL2,Ccl2,Cyp4a14,EDN1,FOS,IL1A,IRS1,KCNJ11,PTGS2 | 475 (22) |
| let-7 | 3.70e-01 | microRNA | NA | -1.09e+00 | 0.0e+00 | AR,AURKB,BCL11A,BCL2L1,BTG2,CDCA7,CEBPD,CHRNA7,EDEM1,EZH2,FOSL1,GAB2,HK2,HMOX1,HNF4A,IL6R,MYC,MYCN,PCK1,PLAUR,PNKD,PTGS2,SERPINE1,SOX2,THBS1,TRIB1,ZFP36 | 450 (18) |
| IL27RA | -4.70e-01 | transmembrane receptor | NA | -1.09e+00 | 0.0e+00 | Ccl2,CCL4,CD69,CXCL10,IL12B,LCN2,LTA,LTB,SOCS3,STAT1,TBX21 | 355 (17) |
| dimethyl fumarate | NA | chemical drug | NA | -1.09e+00 | 0.0e+00 | F3,HMOX1,KDR,PTGS2,SELE,SERPINE1 | 445 (19) |
| CD86 | -1.00e-01 | transmembrane receptor | NA | -1.09e+00 | 0.0e+00 | BCL2L1,CCL4,CD27,CD28,CD69,FCER2,GZMA,IL2RB,NFKBIA,POU2F2 | 425 (17) |
| FEM1A | 1.20e-01 | transcription regulator | NA | -1.09e+00 | 0.0e+00 | Ccl2,CCL4,CXCL10,CXCL2 | 387 (16) |
| NFAM1 | -3.10e-01 | transmembrane receptor | NA | -1.09e+00 | 0.0e+00 | CCL4,IL12B,IL1A,LTA | 47 (3) |
| KPNA2 | 5.30e-01 | other | NA | -1.09e+00 | 0.0e+00 | BMP6,IFIT1,ISG15,PGF | 181 (7) |
| SRA1 | 4.00e-02 | transcription regulator | NA | -1.09e+00 | 2.0e-02 | DIO2,MMP9,PPARA,THBS1 | NA |
| salinosporamide A | NA | chemical drug | NA | -1.09e+00 | 3.0e-02 | BCL2L1,MMP9,MYC,PTGS2 | NA |
| BCL6 | 5.30e-01 | transcription regulator | NA | -1.09e+00 | 0.0e+00 | BCL2A1,BCL2L1,BMP2,CCL2,Ccl2,CCL4,CCR6,CD19,CD274,CD69,CD79B,CDKN1A,CIITA,CLEC10A,COL2A1,CPT1B,CXCL10,CXCL3,EGR3,FCER2,GABARAPL1,GADD45A,IL12B,IL1A,IL21R,IL24,IL2RB,IL4R,IL6R,IRF4,JUNB,KLHL23/PHOSPHO2-KLHL23,LPIN1,MGP,MYC,Pmaip1,PTPRO,PURG,SERPINE1,SOCS2,SOCS3,STAT1,STXBP4,TBX21,TIMP1,TNFRSF14,TNFRSF18,UBA7 | 537 (16) |
| MYC | 1.14e+00 | transcription regulator | NA | -1.09e+00 | 0.0e+00 | ABL1,ADAMTS1,ALB,APCDD1,AQP1,AR,ATF4,AURKB,BCL2A1,BCL2L1,BMPER,CCNA1,CD19,CD274,CD69,CDCA7,CDKN1A,CEBPD,Clec2d (includes others),CNTRL,COL2A1,CPT1A,CTSV,CXCL10,CXCR4,DDIT4,DDX11,DUSP1,EDN1,Elf5,EPHA2,EZH2,F3,FASN,FKBP5,FOS,FOSL1,GADD45A,GADD45B,GADD45G,GBP2,GBP4,GCLC,GFI1,GLUL,H6PD,HK2,HMOX1,HSD11B2,IER3,IFI44,IFI44L,IFIT1,IL12B,INHBA,IRF4,IRS1,ISG15,KDR,KRT17,KRT7,LOX,LRRN1,MAP4K1,MGP,MMP9,Mt1,MX1,MYBPH,MYC,MYCN,MYCT1,NFKBIA,NOCT,NRP1,Oasl2,ODC1,PAX5,PCK1,PDHA1,PFKFB3,PLA1A,PLAUR,PPARA,PPL,Ppp1r15a,PSAT1,PTGS2,PTPRC,PURG,RSAD2,SAT1,SERPINE1,SERPINH1,SLC11A1,SLC16A3,SLC7A5,SOX2,SPN,STAT1,TGM1,THBS1,TIMP1,TNFRSF12A,TNFRSF19,TNFRSF8,TNFSF10,TP73,TXNIP,TXNRD1,USP18,WNT5A,XPO1,ZFP36 | 436 (15) |
| CHD4 | -5.00e-02 | enzyme | NA | -1.09e+00 | 0.0e+00 | ADORA1,BCL11A,CDKN1A,EZH2,HMOX1,ID4,IL12B,JAK3,LOX,NGFR,SOCS2,SOCS3,TBX21 | 347 (11) |
| FASN | 8.20e-01 | enzyme | NA | -1.09e+00 | 1.0e-02 | CIDEA,DDIT4,FASN,IL12B,PCK1,PNPLA2,PON1,PTGS2,RBP4 | NA |
| retinoid | NA | chemical drug | NA | -1.10e+00 | 0.0e+00 | CDKN1A,DUSP1,EDN1,GTF3A,MYC,PTGS2,SLC10A1,TNFSF10 | 500 (25) |
| FAS | -2.60e-01 | transmembrane receptor | NA | -1.10e+00 | 0.0e+00 | ARL4A,BCL11A,BCL2A1,BCL2L1,CCL2,Ccl2,CCL4,CD22,CD300C,CD83,CDKN1A,CEBPD,CREB1,CXCL10,CXCL2,CXCL3,CXCL6,F2RL1,F3,FOS,GADD45G,GBP2,GNAI2,GRK5,IER3,IFIT1,IL1A,ITGA7,LGALS3,LTB,MERTK,MGP,MMP9,NFKBIA,P2RY10,PGLYRP1,PIK3C2B,PRKCB,PTPRN,PTX3,RSAD2,SELP,SERPINE1,SIT1,STK17B,STK38L,TNFAIP6,TNFSF10,TRIB1,ZFP36 | 385 (13) |
| miR-374b-5p (and other miRNAs w/seed UAUAAUA) | NA | mature microRNA | NA | -1.10e+00 | 1.0e-02 | BMP2,BMP6,IL1A,ZFP36 | 395 (7) |
| SCH 58261 | NA | chemical reagent | NA | -1.10e+00 | 3.0e-02 | FOS,JUNB,LILRB3,NPC2,PTGS2 | NA |
| CYP2J2 | -5.40e-01 | enzyme | NA | -1.11e+00 | 0.0e+00 | BCL2L1,Ccl2,CXCL6,MMP9,NFKBIA,SELE | 374 (17) |
| fish oils | NA | chemical drug | NA | -1.11e+00 | 1.0e-02 | Ccl2,CPT1A,EDN1,FASN,IL1A,PON1,PPARA,PTGS2 | 449 (17) |
| 4-tert-octylphenol | NA | chemical toxicant | NA | -1.11e+00 | 1.0e-02 | AR,GABRP,ITIH4,MYC,SEZ6,Slpi/Slpil2 | NA |
| RORC | NA | ligand-dependent nuclear receptor | NA | -1.11e+00 | 0.0e+00 | ATP1B1,BTLA,CCR6,CD28,CXCL2,CXCL3,Cyp3a25 (includes others),Cyp4a14,CYP7B1,GADD45B,GFPT2,HK2,IL1A,KCNK5,LCN2,LPIN2,Mt1,MYC,NOCT,PCK1,POR,PPP1R3C,PROCR,S100A8,SELENBP1,SLC30A10,SLC7A5,Slco1a1,ZBTB16 | 462 (17) |
| FOXD3 | NA | transcription regulator | NA | -1.12e+00 | 0.0e+00 | CDKN1A,CXCR4,EZH2,RND3,SOX2 | NA |
| NOSTRIN | -2.50e-01 | transcription regulator | NA | -1.12e+00 | 0.0e+00 | Ccl2,KDR,MMP9,PGF,SELE,SELP,THBS1 | 332 (11) |
| PROC | -3.00e-01 | peptidase | NA | -1.12e+00 | 0.0e+00 | BCL2A1,CCL2,Ccl2,CXCL2,CXCL3,IL12B,MMP9,PROCR,SELE,SERPINE1,THBS1 | 330 (15) |
| TFE3 | 3.40e-01 | transcription regulator | NA | -1.13e+00 | 1.0e-02 | CIDEA,FASN,HK2,IRS1,MS4A1,PHOSPHO1,PNPLA2,PPARGC1B,SERPINE1 | 365 (12) |
| NFKB2 | 2.60e-01 | transcription regulator | NA | -1.13e+00 | 0.0e+00 | AR,BCL2L1,BMP2,CCL19,Ccl2,CD83,CDKN1A,CR2,CXCL3,CXCR4,FCER2,FOS,GBP5,IRF4,KCNMB4,KRT7,LTA,MMP9,MYC,Pcp4l1,PPARGC1B,PTGS2,SELL,TNFRSF14 | 360 (15) |
| ZBTB16 | 8.20e-01 | transcription regulator | NA | -1.13e+00 | 0.0e+00 | ACER2,BMP2,BMP7,Ccl2,CCR6,CD14,CD180,CD200R1L,CD274,CD3G,CD83,CD8A,CDKN1A,CXCL10,F2RL1,H6PD,HSD17B2,IL12B,IL1A,IL21R,IL4R,Klrk1,LMO4,LY86,MMP9,MYC,ODC1,PAX5,PDGFB,Pla2g12a,PPARA,PTGS2,SELL,SELP,SGMS1,SLAMF6,TNFSF8,UCK2,ZBTB16 | 524 (24) |
| IFNA21 | NA | cytokine | NA | -1.13e+00 | 0.0e+00 | CXCL10,IFIT1,ISG15,MX1,ZBP1 | 277 (12) |
| T 0070907 | NA | chemical reagent | NA | -1.13e+00 | 0.0e+00 | Ccl2,CDKN1A,HMOX1,PTGS2 | 376 (17) |
| SDC1 | 4.00e-02 | enzyme | NA | -1.13e+00 | 0.0e+00 | Ccl2,CXCL2,CXCL3,GALNT3,JUNB | 385 (17) |
| liquiritigenin | NA | chemical - endogenous non-mammalian | NA | -1.13e+00 | 0.0e+00 | ABCB11,ABCC2,FOS,HMOX1 | 415 (13) |
| UBR5 | NA | enzyme | NA | -1.13e+00 | 0.0e+00 | CD163,CD27,CD274,CDKN1A,CXCL10,CXCL3,ISG15,KRT7,NRP1,OAS2,SELP,SOX2,STAT1 | 381 (10) |
| Sb202190 | NA | chemical drug | NA | -1.13e+00 | 0.0e+00 | ABCB1,CCL2,Ccl2,CDKN1A,CRP,CXCL10,FCER2,FOS,HAS1,HMOX1,IFIT1,IL12B,JUNB,MMP9,P4HA1,PPARA,PPARGC1B,PTGS2,S100A8,SELE,SERPINE1,TGM1,XDH | 417 (15) |
| evodiamine | NA | chemical - endogenous non-mammalian | NA | -1.13e+00 | 0.0e+00 | ABCB1,BCL2A1,BCL2L1,MMP9,MYC,PTGS2,SELE | 382 (15) |
| S100A6 | 3.40e-01 | transporter | NA | -1.13e+00 | 0.0e+00 | ADAMTS1,ATF3,CXCL2,INHBA,PBK,PCDHB2,SELE | 405 (12) |
| Hbb-b2 | NA | other | NA | -1.13e+00 | 0.0e+00 | Ccl2,CIITA,CXCL10,FTL,IL2RB,LTB,LY86,SERPINF2 | 290 (7) |
| KCNK9 | 2.00e-01 | ion channel | NA | -1.13e+00 | 1.0e-02 | GADD45B,GAL,LCN2,SEZ6L,SLC16A3,SLC6A17,ST6GALNAC5 | NA |
| HDAC1 | 1.10e-01 | transcription regulator | NA | -1.14e+00 | 0.0e+00 | ABCB1,AR,ATF3,CCNA1,CD27,CDKN1A,COL2A1,DAB2IP,DUSP1,EPGN,FAM107A,FGFBP1,FOS,GABARAPL1,GFI1,GLI1,GLUL,IL1A,IL24,ITGAD,KDR,LCN2,Meis1,MMP9,Mt1,MYC,Nes,NEXN,NFKBIA,PCK1,PDGFB,PFKFB3,PPP2R2B,PTGS2,SERPINE1,SOX2,SYCE1,TBX6,THEMIS,TNFRSF19,TP73 | 478 (24) |
| Sn50 peptide | NA | chemical toxicant | NA | -1.14e+00 | 0.0e+00 | BCL2A1,BCL2L1,Ccl2,CRP,CXCL10,CXCL2,GNAI2,GZMB,HMOX1,MMP9,MYC,PTGS2,SERPINE1,TNFRSF21,TNFSF10 | 417 (14) |
| S100A8 | -7.60e-01 | other | NA | -1.14e+00 | 0.0e+00 | ADAMTS1,ADAMTS4,ADAMTS5,ARG2,ATF3,BCL2L1,BHLHE40,CCL2,Ccl2,CD274,CD69,CXCL10,CXCL2,CXCL3,DDIT4,FOSL1,GJB2,GZMB,HMOX1,IL1A,IL33,ISG15,KLF15,MMP9,MRO,MYC,MYCT1,NFKBIA,NGFR,NTRK3,PER1,PIK3IP1,PTPRO,RAB20,RBFOX1,RNASE6,S100A8,SDCBP2,SIX1,SLC26A1,SLC6A12,SOCS3,Spry1,TXNIP,USP18 | 454 (17) |
| USP22 | 2.50e-01 | peptidase | NA | -1.15e+00 | 2.0e-02 | BCL2A1,CDKN1A,CSF3R,IFIT1,IL2RB,LRRN1,MERTK,PTPRC,SEMA4F,TBX21,USP18 | NA |
| CCL11 | -2.80e-01 | cytokine | NA | -1.15e+00 | 0.0e+00 | BCL2L1,BMP6,CCL2,CCL28,CCL4,CCR3,CXCL2,CXCL3,CXCL6,XCR1 | 367 (19) |
| batimastat | NA | chemical - protease inhibitor | NA | -1.15e+00 | 2.0e-02 | CXCL3,FCER2,MMP9,SDC4 | NA |
| PARP14 | -5.00e-01 | enzyme | NA | -1.15e+00 | 0.0e+00 | CXCL10,F3,FCER2,ISG15,Mx2 | 372 (19) |
| AIMP1 | 1.20e-01 | cytokine | NA | -1.15e+00 | 1.0e-02 | CCL2,CCL4,CXCL2,IL12B | 224 (9) |
| N-ethyl-N-nitrosourea | NA | chemical toxicant | NA | -1.16e+00 | 0.0e+00 | CCL17,CCL2,CCL24,CDKN1A,CRP,CXCL2,CXCL6,IFI44,ISG15,Mt1,Mx2,OAS2,Oasl2,TIMP1,TNFSF8 | NA |
| AIP | -2.00e-02 | transcription regulator | NA | -1.16e+00 | 0.0e+00 | ADRA1D,C3AR1,CX3CR1,CYSLTR1,DUSP1,F2RL1,NPR3,P2RY14,PPARA,RASGRP1,RGS16,RGS18 | NA |
| CGAS | NA | enzyme | NA | -1.17e+00 | 0.0e+00 | CD274,CDKN1A,CXCL10,IFI44,IFI44L,IFIT1,IL1A,ISG15,MAP1LC3B,Mx2,RSAD2,USP18 | 351 (19) |
| Go 6976 | NA | chemical drug | NA | -1.17e+00 | 0.0e+00 | BCL2L1,BMP2,BMP6,Ccl2,CCL4,CD83,CDKN1A,CXCL10,CXCL2,CXCL3,CXCL6,FOS,HMOX1,IL12B,MMP9,NFKBIA,PTGS2 | 307 (14) |
| ADRB | NA | group | NA | -1.17e+00 | 0.0e+00 | ABL1,ADAMTS4,ANKRD1,ATF3,BHLHE40,Ccl2,CDKN1A,CREM,CXCL10,CXCL2,DDIT4,DIO2,ENDOD1,FOS,GADD45A,HMOX1,JUNB,LPIN1,MMP9,NFKBIA,PDGFB,PTGS2,RSAD2,TRIM54 | 463 (18) |
| PLCG1 | -6.00e-02 | enzyme | NA | -1.17e+00 | 0.0e+00 | CCL2,FOS,KDR,SERPINE1,THBS1 | 462 (21) |
| MAS1 | 4.00e-02 | G-protein coupled receptor | NA | -1.17e+00 | 1.0e-02 | Ccl2,CLEC10A,CX3CR1,FASN | 502 (21) |
| SMPD1 | 1.00e-02 | enzyme | NA | -1.18e+00 | 0.0e+00 | ACKR4,CCL2,CCL28,CCL4,CCR3,CXCL2,CXCR4,DIO1,MAP1LC3B,TNFSF10 | 450 (20) |
| N-Ac-Leu-Leu-norleucinal | NA | chemical - protease inhibitor | NA | -1.18e+00 | 0.0e+00 | APOB,ATF4,BCL2L1,CCL2,CCL4,CDKN1A,CREB1,IER3,MYCN,NEDD9,NFKBIA,PTGS2,SELP,TP73 | 493 (21) |
| dexmedetomidine | NA | chemical drug | NA | -1.18e+00 | 0.0e+00 | CCL2,Ccl2,CDKN1A,DDIT4,EPHA2,FOS,MYC,NGFR,OSMR,PTGS2 | 451 (19) |
| IFNA10 | NA | cytokine | NA | -1.18e+00 | 0.0e+00 | CXCL10,IFIT1,ISG15,MX1,ZBP1 | 277 (12) |
| IFNA5 | NA | cytokine | NA | -1.18e+00 | 0.0e+00 | CXCL10,IFIT1,ISG15,MX1,ZBP1 | 328 (15) |
| IFNA7 | NA | cytokine | NA | -1.18e+00 | 0.0e+00 | CXCL10,IFIT1,ISG15,MX1,ZBP1 | 277 (12) |
| IFNA6 | NA | cytokine | NA | -1.18e+00 | 0.0e+00 | CXCL10,IFIT1,ISG15,MX1,ZBP1 | 328 (15) |
| IFNA16 | NA | cytokine | NA | -1.18e+00 | 0.0e+00 | CXCL10,IFIT1,ISG15,MX1,ZBP1 | 277 (12) |
| CEBPE | 8.00e-02 | transcription regulator | NA | -1.19e+00 | 0.0e+00 | BCL2L1,CD14,CLEC10A,CSF3R,CTSV,LCN2,MMP8,MMP9,MYC,PTGS2,Retnlg,SELL | 221 (7) |
| HSD17B4 | 1.60e-01 | enzyme | NA | -1.20e+00 | 0.0e+00 | BMP2,Cyp4a14,FASN,GLI1,PDK4,PEX11A,PTGS2 | 581 (11) |
| HSPA9 | 1.00e-01 | other | NA | -1.20e+00 | 0.0e+00 | CDKN1A,MMP8,MMP9,MYC,MYCN,NEDD9,SESN2,TIMP1 | 421 (22) |
| mir-10 | NA | microRNA | NA | -1.20e+00 | 1.0e-02 | AR,BCL2L1,CCL2,EDEM1,ERBB3,FKBP5,GAB2,GLI1,HDC,IL6R,IRF4,MKNK2,SMO | 463 (19) |
| LGR4 | 9.00e-02 | transmembrane receptor | NA | -1.20e+00 | 0.0e+00 | CD14,CXCL10,GLUL,IL1A,MMP9,MYC,SLC13A3,WNT5A,WNT7A,ZEB2 | 421 (17) |
| SOX4 | NA | transcription regulator | NA | -1.20e+00 | 0.0e+00 | Acot1,ADAMTS4,ADAMTS5,ADGRE5,B3GNT5,BCAR3,BLK,EIF4E3,EZH2,FOS,GFI1,GNRH1,HIPK2,KYNU,LCK,LRRN3,Mt1,NRP1,PLXNA1,PLXND1,RNF144A,SELL,TNFRSF19 | NA |
| NSC23766 | NA | chemical reagent | NA | -1.21e+00 | 1.0e-02 | BCL2L1,HMOX1,HSD11B2,PTGS2,SELP | 300 (14) |
| ANXA1 | 1.50e-01 | enzyme | NA | -1.21e+00 | 0.0e+00 | CCL2,CCR10,CD69,CD83,CXCL2,CXCR4,LGALS3,PTGS2,SELL,SPHK1 | 454 (15) |
| linolenic acid | NA | chemical - endogenous mammalian | NA | -1.21e+00 | 1.0e-02 | EDN1,FASN,NFKBIA,SELP,SERPINE1 | NA |
| PPARG | -4.30e-01 | ligand-dependent nuclear receptor | NA | -1.22e+00 | 0.0e+00 | AQP3,ARL4D,BCL2L1,CCL17,CCL2,Ccl2,CD274,CDKN1A,CIDEA,CPT1A,CPT1B,CR2,CREB1,CXCL2,CXCL3,CXCL6,Cyp4a14,DLK1,EDN1,FABP3,FASN,FOSL1,H6PD,HCAR1,HK2,HMOX1,IL33,IRS1,ITGAD,Kctd12b,MKNK2,MMP9,MUC13,NPR3,ODC1,PCK1,PCLO,PCTP,PDK4,PEX11A,PFKFB3,PLIN5,PPARA,PPARGC1B,PPP2R2B,PTGER3,PTGS2,RAB20,RBP4,S100A8,SAT1,SELE,SERPINE1,SFTPB,SMO,SOCS3,TNFSF10,TRERF1 | 470 (19) |
| KDM4D | 1.50e-01 | enzyme | NA | -1.22e+00 | 0.0e+00 | CD274,CDKN1A,GLI1,IL12B | NA |
| tyrphostin AG490 | NA | chemical drug | NA | -1.22e+00 | 0.0e+00 | BCL2L1,BMP7,CCL2,Ccl2,CD274,CDKN1A,CXCL2,EDN1,FOS,MMP9,MYC,PTGS2,PTX3,SFTPB,SOCS3,STAT1,TIMP1,TNFSF10 | 391 (18) |
| triptolide | NA | chemical drug | NA | -1.22e+00 | 0.0e+00 | AR,BCL2L1,BMP6,CALCRL,CDKN1A,DACH1,DUSP1,F2RL1,GCLC,HK2,IER3,IL1A,KDR,MCAM,MYC,PTGS2,SOCS3,TNFSF10 | 465 (17) |
| lenalidomide | NA | chemical drug | NA | -1.23e+00 | 1.0e-02 | BCL11B,BEST3,CD40LG,CTTNBP2,ERN1,FZD10,GZMB,HIPK2,IRF4,MYC,NRP1,PRF1,PTPRC,RAD18,RGS16,RNF213,SPSB1,STAMBPL1,TET1,TNFRSF21,TP73,WDR72,WNT11 | NA |
| RMRP | NA | other | NA | -1.23e+00 | 2.0e-02 | BTG2,CDKN1A,COL2A1,RSAD2 | NA |
| EZR | -3.00e-02 | other | NA | -1.23e+00 | 0.0e+00 | ATF3,ATF4,BCL2L1,DDIT4,MMP9,MYC,PTGS2 | 393 (20) |
| everolimus | NA | chemical drug | NA | -1.23e+00 | 4.0e-02 | BCL2L1,CD274,CDKN1A,KDR,MYC,SOAT1 | NA |
| H-7 | NA | chemical - kinase inhibitor | NA | -1.23e+00 | 0.0e+00 | ABCB1,Acan,ECE1,FCER2,FOS,HDC,ISG15,JUNB,Mt1,MYC,SELE,SERPINE1 | 492 (21) |
| MCC950 | NA | chemical reagent | NA | -1.24e+00 | 0.0e+00 | CCL2,Ccl2,CXCL10,CXCL2,CXCL6,MMP9,TIMP1 | 349 (15) |
| PRRX1 | -6.90e-01 | transcription regulator | NA | -1.24e+00 | 4.0e-02 | FOS,MAP1LC3B,PDGFB,SOX2 | NA |
| IFNA8 | NA | cytokine | NA | -1.24e+00 | 0.0e+00 | CXCL10,IFIT1,ISG15,MX1,ZBP1 | 277 (12) |
| EPHB4 | -3.00e-02 | kinase | NA | -1.25e+00 | 0.0e+00 | AR,BMP2,BMP7,CXCR4,KDR,MYC,Nes,PPARGC1B,SHB,WNT11,WNT5A | NA |
| SCH772984 | NA | chemical drug | NA | -1.25e+00 | 0.0e+00 | ATF4,FOS,GLI1,JUNB,MMP9 | 338 (10) |
| BCAP31 | -4.00e-02 | transporter | NA | -1.25e+00 | 1.0e-02 | ADGRE1,Ccl2,CXCL10,EDEM1,ERN1,PDGFB,PGF | NA |
| C5AR2 | -2.10e-01 | G-protein coupled receptor | NA | -1.26e+00 | 1.0e-02 | Ccl2,CXCL2,CXCL3,IL12B | NA |
| KDM1A | 2.30e-01 | enzyme | NA | -1.26e+00 | 0.0e+00 | ACSM1,ADCY5,ATF3,AZGP1,BMP2,C3AR1,CCL2,CCL4,CD22,CD274,CD84,CDKN1A,CIITA,CRYM,CXCL10,ENDOU,FASN,GALNT15,GATA5,GBP2,GBP4,GBP5,HAS3,HMOX1,IFI44,Igtp,IKZF3,IL21R,Irgm1,ISG15,KHDRBS3,LAG3,LCK,Lrrc74b,LY86,Milr1,Mx2,MYC,Oasl2,OSMR,PSAT1,PTPRC,PTX3,RNF213,SERPINB1,SERPINE1,SERPINF2,SLC38A3,SLC43A3,SOCS2,SOX2,SPOCK1,SYBU,TCN2,TGM1,THBS1,USP18,ZBP1 | 517 (23) |
| NEUROG1 | NA | transcription regulator | NA | -1.26e+00 | 0.0e+00 | CEMIP,FABP3,GFPT2,INHBA,LRRN3,MMP9,P4HA2,SLC43A3,SPOCK1,THBS1 | NA |
| CD200R1 | 2.80e-01 | transmembrane receptor | NA | -1.26e+00 | 0.0e+00 | AR,ATF3,CCR6,CCR9,IL2RB,JUNB,MYC,NFKBIA,TNFRSF12A,TNFRSF18 | 532 (20) |
| TPH1 | -3.20e-01 | enzyme | NA | -1.26e+00 | 1.0e-02 | ARRDC3,FCMR,GIMAP4,GIMAP7,GZMA,HMOX1,IL1R2,MAP4K1,SLAMF6,ZNF519 | NA |
| IRF5 | -3.80e-01 | transcription regulator | NA | -1.27e+00 | 0.0e+00 | BCL2L1,CCL19,CCL4,CDKN1A,CMPK2,CXCL10,CXCL2,CXCR4,IFI44,IFIT1,IL12B,ISG15,MYC,OAS2,Oasl2,PTGS2,RSAD2,STAT1,TNFSF10 | 467 (19) |
| PARP2 | -2.30e-01 | enzyme | NA | -1.27e+00 | 0.0e+00 | CCL4,CCR6,CD83,FASN,SFTPB,TBX21,XCL1 | NA |
| GW9662 | NA | chemical reagent | NA | -1.27e+00 | 1.0e-02 | AGR2,CCL2,CD14,CD83,CDKN1A,CX3CR1,FASN,FOS,GCLC,KDR,LCN2,PTGS2 | NA |
| PDCD4 | -8.00e-02 | other | NA | -1.28e+00 | 0.0e+00 | LOX,MAP4K1,MYC,PLAUR,PTGS2 | 532 (19) |
| RNASE2 | NA | enzyme | NA | -1.28e+00 | 1.0e-02 | CCL2,CCL24,CCL4,CD83,CXCL10,IL12B | NA |
| bryostatin 1 | NA | chemical drug | NA | -1.28e+00 | 0.0e+00 | CD22,CXCR4,MS4A1,MYC,ODC1,PRKCB,TBX21 | 488 (18) |
| TMPRSS2-ERG | NA | fusion gene/product | NA | -1.28e+00 | 0.0e+00 | ADORA2B,CBX2,DDIT4,DPYSL5,DUSP8,DYSF,EREG,HCAR1,IFI44,IL1A,INHBA,LTB,LURAP1L,MMP9,MYC,NUPR1,OSBPL6,PLAT,PSAT1,TCEA3,THBS1,ZEB2 | 438 (12) |
| THZ1 | NA | chemical drug | NA | -1.28e+00 | 0.0e+00 | ADAMTSL2,ANKRD1,ATF3,BCL2L1,CTHRC1,DIO2,GEM,LGALS3,LOX,LOXL1,MEOX1,MGP,MYC,NUPR1,SERPINB1,SERPINE1,STK17B,THBS1,TIMP1,TMEM119,TNFRSF8,TRERF1 | 423 (12) |
| olanzapine | NA | chemical drug | NA | -1.29e+00 | 2.0e-02 | ATF3,CDHR1,CHST3,CYSLTR1,FOS,HMOX1,IL2RB,KCNMB4,KLHL41,Mcpt8 (includes others),S100A8 | NA |
| maraviroc | NA | chemical drug | NA | -1.29e+00 | 0.0e+00 | Ccl2,CCL4,CHRNA7,CXCL10,RYR2 | 237 (14) |
| L-histidine | NA | chemical - endogenous mammalian | NA | -1.29e+00 | 0.0e+00 | ATF3,ATF4,DDIT4,SLC38A2 | 460 (20) |
| curcumin | NA | chemical drug | NA | -1.31e+00 | 0.0e+00 | ABCB1,ADAMTS4,ADAMTS5,AQP1,AR,BANP,BCL2L1,CCL2,Ccl2,CDKN1A,CLDN4,CRP,CRY2,CXCL3,CXCR4,EDN1,EZH2,F3,FOS,FOSL1,FOSL2,FTL,GLUL,HMOX1,IRS1,JUNB,MMP9,MYC,NFKBIA,PGF,PNPLA2,PPARA,PPP1R3A,PTGS2,SELE,SERPINB1,SERPINE1,SLC10A1,SOCS3,TET1,TIMP3,UBA7,YPEL1 | 350 (14) |
| agmatine | NA | chemical - endogenous mammalian | NA | -1.31e+00 | 0.0e+00 | BBOX1,BMP2,BMP7,KDR,ODC1,PPARA | NA |
| genistein | NA | chemical drug | NA | -1.31e+00 | 0.0e+00 | APOB,AR,ATF4,ATP6V0A4,BCL2L1,BMP2,CCL2,Ccl2,CD8A,CDKN1A,CHST7,CTSH,CTSV,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,DIO1,DNASE1L3,DNASE2B,DUSP1,EREG,F3,FCMR,FOS,GADD45A,GCLC,GJB2,GLI1,HAS1,HMOX1,HYAL3,JUNB,KLHL41,KLRD1,LY86,MAOA,MAP4K1,MMP9,Mt1,MYC,NPC2,OSBPL3,PER1,PLAT,PTGS2,RASGRP1,SERPINE1,SLC11A1,Slco1a1,SLFN12,SPHK1,STK17B,WNT5A,ZEB2 | 462 (19) |
| pyrrolidine dithiocarbamate | NA | chemical reagent | NA | -1.31e+00 | 0.0e+00 | BCL2A1,BCL2L1,BMP2,CCL2,Ccl2,CCL4,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DUSP8,GBP2,GCLC,GNAI2,GZMB,HMOX1,IL1A,MMP9,MYC,NFKBIA,PPARA,PRF1,PTGS2,SELE,SELP,SERPINE1 | 413 (13) |
| rottlerin | NA | chemical drug | NA | -1.32e+00 | 0.0e+00 | AQP1,Ccl2,CDKN1A,CIITA,CLDN4,CXCL3,ECE1,FKBP5,HMOX1,MMP9,PDGFB,PTGS2,ZFP36 | 329 (16) |
| ochratoxin A | NA | chemical toxicant | NA | -1.32e+00 | 1.0e-02 | BCL2L1,GCLC,Gsta1,MMP9,TIMP1 | 207 (7) |
| SOX11 | 3.00e-02 | transcription regulator | NA | -1.33e+00 | 2.0e-02 | ADAMTS4,ADAMTS5,BMP2,CD19,CDH26,CXCR4,FCMR,GNRH1,IKZF3,LCK,MS4A1,PAX5,STAT1,YPEL1 | NA |
| fulvestrant | NA | chemical drug | NA | -1.34e+00 | 0.0e+00 | ABL1,ACOX2,ATF4,BMP2,CA12,CBS/LOC102724560,CCL2,Ccl2,CDKN1A,CEBPD,CXCL10,DDIT4,DYNLL1,EGR3,ERBB3,FOS,FOSL2,GAB2,GADD45A,GAL,GJB2,IER3,IRS1,MAP2K6,MMD,MYC,NGFR,NRP1,PAX5,PTGER3,PTGS2,RBM14,SELP,SEMA7A,SLC7A5,TGFA,TGFBR3,TXNIP | 595 (25) |
| CDX-3379 | NA | biologic drug | NA | -1.34e+00 | 0.0e+00 | CCL17,CCL2,Ccl2,IL1A,LIF | 372 (12) |
| RXRB | -2.00e-02 | ligand-dependent nuclear receptor | NA | -1.34e+00 | 0.0e+00 | ATF4,CAMK1D,CCL17,CD200R1L,CXCL10,EHD3,FASN,FLRT3,GADD45G,GFI1,HNF4A,HSF2BP,IL1A,LCN2,MUC13,NUPR1,OSMR,PDGFB,PLCL1,PURG,RGN,S100A8,SELP,TNFSF10,Tnfsf9,ZC3H12A | 412 (11) |
| MS4A1 | -1.10e+00 | other | NA | -1.34e+00 | 0.0e+00 | CD19,CD22,CD69,HK2,MYC,PAX5 | 208 (7) |
| ebselen | NA | chemical drug | NA | -1.34e+00 | 0.0e+00 | ADGRE1,DUSP1,GCLC,HMOX1,PTGS2 | 351 (19) |
| MEIS2 | -4.60e-01 | transcription regulator | NA | -1.34e+00 | 0.0e+00 | BMP2,OSR1,OSR2,SHOX2,WNT5A,XCL1 | NA |
| N-(1-carbamoyl-2-phenyl-ethyl) butyramide | NA | chemical reagent | NA | -1.34e+00 | 0.0e+00 | ADGRE1,CD14,PPARA,PTGS2,SOCS3 | 216 (7) |
| harmine | NA | chemical - endogenous non-mammalian | NA | -1.34e+00 | 0.0e+00 | BCL2L1,BMP2,FOS,PPARA,PTGS2 | 337 (7) |
| THZ2 | NA | chemical drug | NA | -1.34e+00 | 1.0e-02 | CDKN1A,FOSL2,IRAK2,LIF,MYC | NA |
| GHR | -4.10e-01 | transmembrane receptor | NA | -1.34e+00 | 2.0e-02 | Ccl2,CDKN1A,GHRHR,MYC,SOCS2,SOCS3,TRPA1,TRPV1 | NA |
| citarinostat | NA | chemical drug | NA | -1.34e+00 | 2.0e-02 | LIF,NEDD9,RCL1,TNFRSF12A,TXNIP | NA |
| CA9 | -2.80e-01 | enzyme | NA | -1.34e+00 | 4.0e-02 | Acan,ARG2,CA12,COL2A1,SLC6A6 | NA |
| Perm1 | -5.00e-01 | other | NA | -1.34e+00 | 4.0e-02 | COQ10B,CPT1B,ENO3,ESRRG,PPARA | NA |
| NR1H4 | -1.50e-01 | ligand-dependent nuclear receptor | NA | -1.34e+00 | 0.0e+00 | ABCB11,ABCC2,ADAMTS4,ADGRE1,ANKRD1,BAAT,Ccl2,CCL28,CXCL3,EDN1,FASN,HNF4A,LCN2,MYC,NR0B2,NR5A2,PCK1,PNPLA3,PON1,PPARA,PPARGC1B,PTGS2,SEMA7A,SERPINC1,SLC10A1,Slco1a1,TIMP1,TNFSF8,TXNIP | 493 (24) |
| N-[N-(3,5-difluorophenacetyl-L-Ala)]-S-phenylglycine t-butyl ester | NA | chemical - protease inhibitor | NA | -1.35e+00 | 0.0e+00 | BCL2L1,Ccl2,COL2A1,CXCL2,CXCR4,FSTL3,GADD45B,HSF2BP,IER3,IL1A,INHBA,JUNB,KDR,LOX,MAOB,PDGFB,RND3,SERPINE1,SOX2,TFPI2 | 502 (18) |
| amino acids | NA | chemical - endogenous mammalian | NA | -1.35e+00 | 0.0e+00 | FOS,JUNB,MYC,ODC1,SELE,SLC38A2,SLC7A1 | 456 (20) |
| MTA1 | 7.00e-02 | transcription regulator | NA | -1.35e+00 | 0.0e+00 | ACTC1,BCL2L1,EPHA2,EZH2,HUNK,MMP9,MYC,PAX5,SERPINB1 | 425 (21) |
| SIGIRR | -3.90e-01 | transmembrane receptor | NA | -1.35e+00 | 1.0e-02 | Ccl2,CXCL2,CXCL3,IL1A,S100A8 | NA |
| DLX1 | -2.00e-01 | transcription regulator | NA | -1.35e+00 | 1.0e-02 | BCL2L1,BMPER,CAP2,CDH6,CTHRC1,SERPINE1,SNTB1,SOX2,WNT5A | NA |
| budesonide | NA | chemical drug | NA | -1.36e+00 | 1.0e-02 | ABLIM1,ARHGAP10,AURKB,BLK,Ccl2,CDKN1A,CXCL10,CXCL2,CYP2S1,DYNLL1,ENDOU,EREG,GNAI2,GRHL1,HDC,KRT7,LOX,LPIN1,MAP2K6,PFKFB3,PPL,PRKCG,SLC16A9,SRGAP1,TNFAIP6,TP53BP2,WNT5A | NA |
| GATA6 | -1.80e-01 | transcription regulator | NA | -1.36e+00 | 1.0e-02 | ABCB1,ACTC1,ASPA,CD163,CD5L,CDKN1A,CLEC10A,DLK1,EDN1,Elf5,HNF4A,KRT17,KRT7,LYVE1,MYC,NR5A2,PPL,SORBS3,SOX2,SOX7,TNFSF10 | 261 (7) |
| ENG | 9.00e-02 | transmembrane receptor | NA | -1.36e+00 | 2.0e-02 | CXCR4,KDR,MYC,PDGFB,SERPINE1,THBS1 | NA |
| 2-arachidonoylglycerol | NA | chemical - endogenous mammalian | NA | -1.37e+00 | 0.0e+00 | CREB3L3,F3,LPIN1,PCK1,PPARA,PTGS2 | 438 (20) |
| ILF3 | 4.00e-02 | transcription regulator | NA | -1.38e+00 | 0.0e+00 | ATF3,C3AR1,CCDC170,CD14,CD163,CIITA,CXCL10,FKBP5,FOS,IL4R,ISG15,LGALS3,PLAUR,SEMA7A,TNFRSF12A | 293 (7) |
| wortmannin | NA | chemical drug | NA | -1.38e+00 | 0.0e+00 | AQP3,AR,ATF3,BCL2L1,CCL2,Ccl2,CCL4,CCR3,CD14,CD274,CDKN1A,CEBPD,CIDEA,CREB1,CRP,CXCL10,ERBB3,F3,FASN,FOS,GCLC,HMOX1,IL12B,IRS1,MAP1LC3B,MMP9,MYC,NFKBIA,OGT,P4HA1,PTGS2,SELE,SELP,SERPINE1,SLC6A12,SLC6A2,SOCS2,SOCS3,TNFSF10 | 436 (17) |
| STEAP3 | -3.50e-01 | transporter | NA | -1.39e+00 | 0.0e+00 | ACER2,ADORA2A,BMP6,ERRFI1,KLF15,LOX,NEDD9,NUPR1,P4HA1,RGCC,SHB,SORBS3,TNFRSF12A | NA |
| TFRC | 2.00e-02 | transporter | NA | -1.39e+00 | 0.0e+00 | ATF3,ATF4,CDKN1A,DDIT4,FOS,FTL,GADD45A,GAS7,HK2,HMOX1,PFKFB3,Pmaip1,TFR2,TNFRSF12A,TNFSF10,TREML2 | 293 (13) |
| MOGAT1 | NA | enzyme | NA | -1.39e+00 | 0.0e+00 | Ccl2,CPT1A,CREB3L3,CXCL10,TIMP1 | 244 (7) |
| mesalamine | NA | chemical drug | NA | -1.39e+00 | 0.0e+00 | CD274,HMOX1,ODC1,PPARA,PTGS2 | 570 (20) |
| IFNL2 | NA | other | NA | -1.39e+00 | 0.0e+00 | CXCL10,CXCR4,IFIT1,MX1,RSAD2 | 322 (16) |
| 10-(6’-ubiquinonyl)decyltriphenylphosphonium | NA | chemical drug | NA | -1.39e+00 | 0.0e+00 | CPT1A,IL1A,KDR,PTGS2,SOCS3 | 485 (19) |
| Mt1 | 1.96e+00 | other | NA | -1.39e+00 | 0.0e+00 | ATF3,FOS,Mt1,MYC,NFKBIA,SERPINE1 | 536 (17) |
| pimozide | NA | chemical drug | NA | -1.39e+00 | 0.0e+00 | BCL2L1,CCL17,EPGN,EREG,PRF1 | 143 (6) |
| RYR2 | -7.30e-01 | ion channel | NA | -1.39e+00 | 2.0e-02 | CREB3L3,EDEM1,PCK1,PPARA,SCN4B | NA |
| ADAM15 | 3.40e-01 | peptidase | NA | -1.39e+00 | 2.0e-02 | ITGA7,KDR,NEXN,PKP1,PPP3R1 | NA |
| SERPINF1 | -5.40e-01 | other | NA | -1.39e+00 | 0.0e+00 | BCL2A1,BCL2L1,G0S2,LOXL1,MYC,NFKBIA,SELP,THBS1,TNFSF10 | 419 (13) |
| MEF2C | -5.10e-01 | transcription regulator | NA | -1.39e+00 | 0.0e+00 | ACTC1,ASPA,ATF3,BLK,CCL2,Ccl2,CCL4,CDKN1A,COL2A1,CPT1B,CXCL2,CXCL6,CXCR4,FOS,GNRH1,HAPLN2,IRF4,JUNB,KCNA5,LAG3,MMP8,PDLIM3,Pln,PPARA,PTGS2,RAB37,RYR2,S100A8,SRPK3,THBS1,ZFP36 | 394 (22) |
| MIR17HG | NA | other | NA | -1.40e+00 | 2.0e-02 | APCDD1,CD274,CDKN1A,CREB1,DAB2IP,DLL1,ECE1,FRAS1,LAMA5,MYCN,Sik1,TBX6,WNT5A | NA |
| caffeic acid phenethyl ester | NA | chemical drug | NA | -1.40e+00 | 0.0e+00 | ABCB1,ABL1,BCL2L1,Ccl2,CD83,CDKN1A,CXCL10,CXCL3,F3,FTL,GNAI2,HMOX1,NFKBIA,NGFR,PTGS2 | 388 (15) |
| IFNA14 | NA | cytokine | NA | -1.40e+00 | 0.0e+00 | CXCL10,IFIT1,ISG15,MX1,RSAD2,ZBP1 | 153 (7) |
| mir-3622 | NA | microRNA | NA | -1.40e+00 | 0.0e+00 | CDKN1A,GADD45A,GADD45B,MYC,SESN1 | NA |
| PD 169316 | NA | chemical drug | NA | -1.40e+00 | 0.0e+00 | CDKN1A,PPARGC1B,PTGS2,SLC6A2,TIMP3 | 434 (19) |
| mir-15 | NA | microRNA | NA | -1.40e+00 | 0.0e+00 | AR,CCL2,Ccl2,CD69,FASN,IFIT1,ISG15,MMP9,MX1,PLAUR,PNPLA2,PNPLA3,PTGS2,TIMP1 | 389 (17) |
| RNASE1 | NA | enzyme | NA | -1.41e+00 | 0.0e+00 | CCL2,CCL24,CCL4,CXCL10,FCER2,IL12B | NA |
| amiloride | NA | chemical drug | NA | -1.41e+00 | 1.0e-02 | ATP1A1,BCL2L1,PLAUR,PTGS2 | 449 (20) |
| IFNE | NA | cytokine | NA | -1.41e+00 | 0.0e+00 | ANGPTL3,CD83,CDKN1A,CXCL10,ISG15,PTGS2,STAT1,USP18,ZBP1 | 325 (18) |
| maneb | NA | chemical toxicant | NA | -1.41e+00 | 2.0e-02 | BCL2L1,CCL19,CEBPD,INHBA,KCNA2,MAPK15,STON2,TBCK | NA |
| TRAF3 | -3.50e-01 | enzyme | NA | -1.41e+00 | 3.0e-02 | CXCL10,CXCL2,CXCL3,FCER2,IL12B,IL2RB,ISG15,NFKBIA,ST8SIA6,TBX21,TNFRSF18 | NA |
| mir-101 | NA | microRNA | NA | -1.41e+00 | 3.0e-02 | CLDN5,DUSP1,EZH2,PTGS2 | NA |
| TFAM | -3.00e-02 | transcription regulator | NA | -1.41e+00 | 4.0e-02 | BCL2A1,CD27,FABP3,GIMAP4,MUC13,PPARA,SLC2A10,TNS4,ZBTB16 | NA |
| RARB | -1.80e-01 | ligand-dependent nuclear receptor | NA | -1.42e+00 | 0.0e+00 | ARHGAP4,ATP6V0A4,BCL2A1,CDKN1A,CXCL2,CYP26B1,GADD45A,GBP2,GJB4,IFIT1,Igtp,Irgm1,Meis1,PTGER3,PTGS2,SLC10A1,SLC26A3,SOX2,STAT1,TGM1,UBA7,USP18 | 521 (22) |
| propranolol | NA | chemical drug | NA | -1.42e+00 | 0.0e+00 | CD274,DIO2,DUSP1,FOS,HK2,LGALS12,MAOA,MYC,NFKBIA,Pln,PTGS2,SELP,Sik1 | 413 (17) |
| STING1 | NA | other | NA | -1.43e+00 | 0.0e+00 | BLK,CCL2,CCL4,CD83,CX3CR1,CXCL10,CXCL2,CXCL3,GAS7,GBP4,GBP5,HDC,IFI44,IFI44L,IFIT1,IL1A,IL22RA2,IL33,IL4R,INHBA,ISG15,JAK3,KLRD1,LCN2,LIF,MX1,PLAT,PLAUR,PTPRC,RGS16,RSAD2,SLC11A1,THBS1,UPP1,USP18 | 303 (19) |
| stallimycin | NA | biologic drug | NA | -1.43e+00 | 0.0e+00 | BMP3,BMP7,CXCL10,F3,IFI44,IFIT1,IL1A,IL24,INHBA,IRF4,ISG15,MX1,STAT1,TGFA,TNFSF10 | 421 (16) |
| RBPJ | -3.00e-02 | transcription regulator | NA | -1.43e+00 | 0.0e+00 | BMP2,BMP3,BMP7,CDCA7,CDKN1A,CIITA,CR2,CRP,CXCL3,DLL1,DUSP1,EPHA4,EZH2,FGF11,FOS,INHBA,KDR,LIF,MYC,PDGFB,PGF,PTGIR,SLC25A35,SOX2,WNT5A | 458 (20) |
| trabectedin | NA | chemical drug | NA | -1.43e+00 | 0.0e+00 | ABCB1,CDKN1A,CXCL10,EZH2,GADD45A,GNAI2,GZMB,MX1,PRF1,SAT1 | 408 (12) |
| APLN | 3.50e-01 | other | NA | -1.43e+00 | 0.0e+00 | CIDEA,CXCR4,FOS,GFI1,IRS1,ITGA2B,KDR,MYC,Nes,PDGFB,SERPINH1,SOX18,SPN,TESC,TMEM26 | 462 (25) |
| CXCR3 | 8.00e-02 | G-protein coupled receptor | NA | -1.43e+00 | 0.0e+00 | BCL2L1,Ccl2,CD69,CXCL10,HMOX1,MAP1LC3B,PRF1,SLC26A3,TBX21 | 429 (19) |
| FFAR3 | NA | G-protein coupled receptor | NA | -1.43e+00 | 0.0e+00 | BCL11A,CBS/LOC102724560,CCL28,CXCL10,GBP2,IL1A,KCNH1,KLF15,LAX1,LY86,MLPH,P4HA2,RCN1,SCN1B,SGIP1,SPOCK1 | NA |
| CYP7A1 | -2.80e-01 | enzyme | NA | -1.43e+00 | 1.0e-02 | Ccl2,CYP7B1,FASN,PTGS2,TIMP1 | 533 (24) |
| miR-21-5p (and other miRNAs w/seed AGCUUAU) | NA | mature microRNA | NA | -1.44e+00 | 1.0e-02 | BCL2L1,BTG2,CD274,CD69,CDKN1A,IL6R,KDR,SESN1,Spry1,TIMP3 | 406 (16) |
| NAB2 | 0.00e+00 | transcription regulator | NA | -1.45e+00 | 0.0e+00 | CDKN1A,F3,FOS,ID4,TNFSF10 | 426 (19) |
| calphostin C | NA | chemical drug | NA | -1.45e+00 | 0.0e+00 | ABCB1,BCL2L1,CCL2,CDKN1A,DUSP1,ECE1,FOS,MAOB,MMP9,MYC,POU2F2,PTGS2,S100A8 | 365 (18) |
| IFN alpha/beta | NA | group | NA | -1.45e+00 | 0.0e+00 | CCL2,CCL24,CD69,CD83,CLEC10A,CXCL10,GAS7,Irgm1,ITGA2B,Mx2,Pmaip1,RNF213,RSAD2,STAT1,TLR5,TNFSF10,TREM3 | 351 (15) |
| RARA | 0.00e+00 | ligand-dependent nuclear receptor | NA | -1.45e+00 | 0.0e+00 | ABCC2,ABLIM1,ADH1C,AR,ARNT2,ATP6V0A4,CA12,CCNA1,CCR9,CD14,CD84,CDKN1A,CYP26B1,DUSP1,EGR3,FGFR4,FOS,FOSL2,FOXC1,GJB4,GLI1,IFI44,IFI44L,IL1A,IL6R,MAOB,Meis1,MGP,MYC,MYCN,NEDD9,NRP1,PBK,PCK1,PTGS2,RASGRP4,RSAD2,SELL,SESN1,SFPQ,SFTPB,SGSM3,SLC10A1,SOX2,STAT1,TRH,UBA7,UBXN10,YPEL1 | 586 (24) |
| miR-128-3p (and other miRNAs w/seed CACAGUG) | NA | mature microRNA | NA | -1.45e+00 | 1.0e-02 | ADORA2B,AFF1,NTRK3,TGFBR3,TXNIP | NA |
| FOXM1 | 2.90e-01 | transcription regulator | NA | -1.45e+00 | 0.0e+00 | AR,AURKB,Ccl2,CCL4,CCNA1,CDKN1A,CRP,EZH2,FOS,HSD11B2,KDR,LOX,MMP9,MYC,MYCN,MYOCD,Nes,PLAUR,SFTPB,SOX2,ZEB2 | 445 (19) |
| LCOR | NA | transcription regulator | NA | -1.46e+00 | 0.0e+00 | ADORA1,CDKN1A,CYP26B1,FKBP5,TFPI2 | NA |
| COL18A1 | 8.00e-02 | other | NA | -1.46e+00 | 0.0e+00 | BCL2L1,CCL2,DDIT4,EDN1,F10,F2RL1,F3,FOS,HK2,JUNB,KDR,MYC,NRP1,PTGS2,SELP,SERPINE1,SPOCK1,STAT1,THBS1,TNFRSF21 | 458 (20) |
| CLIC4 | 3.90e-01 | ion channel | NA | -1.46e+00 | 1.0e-02 | CX3CR1,CXCL2,HMCN1,IER3,IL12B,MYRIP,SLC16A3,TIMP3 | NA |
| lapatinib | NA | chemical drug | NA | -1.46e+00 | 0.0e+00 | EREG,FOS,FOSL1,FOSL2,HNF4A,JUNB,MAP1LC3B,PPARA,SOX2,WNT7A | 460 (18) |
| tretinoin | NA | chemical drug | NA | -1.47e+00 | 0.0e+00 | ABLIM1,ACTC1,ADAMTS4,ADAMTS5,ADCYAP1R1,ADGRE1,ANXA8/ANXA8L1,APCDD1,AQP1,AR,ASB2,ATF3,ATF4,ATP6V0A4,BCL2A1,BCL2L1,BHLHE40,BMP2,BMP6,BTG2,C3AR1,CBS/LOC102724560,CCL19,CCL2,Ccl2,CCL24,CCL4,CCNA1,CCR9,CD101,CD14,CD274,CD300C,CDCA7,CDH6,CDKN1A,CIDEA,CLDN11,Clec2d (includes others),COL2A1,CPT1A,CPT1B,CREM,CSF3R,CSRNP1,CUBN,CX3CR1,CXCL10,CXCL2,CXCL6,CXCR4,CYP26B1,CYP2R1,CYP2S1,Cyp4a14,DIO2,DLL1,DMC1,DNASE1L3,DPYSL5,DUSP1,DUSP9,DYNLL1,ECE1,EDN1,ERRFI1,F3,FASN,FERMT1,FGFR4,FOS,FOSL1,FOSL2,FOXC1,FRAT2,FZD10,G0S2,GAL,GAS7,GBP4,GFI1,GHRHR,GJB1,GJB4,GLI1,GZMA,HMOX1,HNF4A,HPX,IAPP,IER3,IFI44,IFI44L,IFIT1,IL12B,IL1A,IL24,IL6R,INHBA,IRF4,IRS1,ISG15,ITGA2B,ITGB7,KCNJ5,KDR,KLF15,KRT7,LCN2,LIMK1,LRRC32,MAOB,MAP3K8,Meis1,MEOX1,MERTK,MGP,MMP8,MMP9,MS4A1,Mt1,MUC5B,MYC,MYCN,MYOCD,Nes,NPC2,NR0B2,Nrgn,NRP1,NTRK3,OAS2,ODC1,P4HA2,PCK1,PCLO,PDGFB,PLAT,PLAUR,PNPLA1,Podxl,POR,PPARA,PPP1R1B,PRKCB,PRKCH,PTGS2,PTPRC,PTX3,RASGRF1,RBM14,RBP4,RCN1,RNF213,RTKN2,S100A8,SELL,SELP,SEMA5B,SEMA6B,SEMA7A,SERPINE1,SFTPB,SIX1,SLC26A3,SLC38A2,SLC6A6,SMPD3,SNX19,SOAT1,SOX2,SOX7,STAT1,TGFBR3,TGM1,THBS1,TIMP1,TLR5,TNFAIP6,TNFRSF19,TNFSF10,Tnfsf9,TP73,TRH,TRPC3,UBA7,USP18,VGLL3,WNT5A,YPEL1,ZBTB16,ZEB2 | 571 (21) |
| mir-19 | NA | microRNA | NA | -1.48e+00 | 4.0e-02 | CDKN1A,CIDEA,F3,RAPGEF4,SOCS3,THBS1 | NA |
| LTA | -7.40e-01 | cytokine | NA | -1.49e+00 | 0.0e+00 | APCS,CCL19,Ccl2,CD274,COL2A1,CRP,HDC,LTA,LYVE1,ODC1,PTGS2,SELL | 471 (16) |
| ATG5 | NA | other | NA | -1.49e+00 | 2.0e-02 | AGR2,CLEC10A,DYNLL1,HK2,IKBKE,IL1A,MAP2K6,PPP2R2B,SELE,SIX1 | NA |
| CDK5 | -5.00e-02 | kinase | NA | -1.50e+00 | 1.0e-02 | CD14,CD274,CDKN1A,CXCL2,PPP1R1B,SPOCK1 | NA |
| DCAF1 | -9.00e-02 | kinase | NA | -1.50e+00 | 0.0e+00 | CDKN1A,Pmaip1,SOCS2,SOCS3,TNFSF10,TXNIP | 394 (7) |
| MTTP | -6.40e-01 | transporter | NA | -1.51e+00 | 0.0e+00 | APOB,CCL4,CPT1A,CXCL3,ERN1,HMOX1,SOAT1 | 247 (7) |
| TCF3 | -2.40e-01 | transcription regulator | NA | -1.51e+00 | 0.0e+00 | ARHGAP4,ASB2,ATF3,AZGP1,CCL28,CCR9,CD200R1L,CD3G,CD79A,CD79B,CDKN1A,CPT1B,CR2,CRELD2,CTSV,DAB2IP,EDEM1,EPB42,GADD45A,GADD45B,GFI1,GIMAP4,GLUL,IL21R,IL2RB,IRF4,ITGB7,LCK,LMO4,MYC,MYCN,NFIL3,NR0B2,NR5A2,NUPR1,PAX5,POU2AF1,PTPRCAP,RGS16,SCIN,SCN4A,SELL,SEMA7A,SERPINB1,SLC7A5,SOCS3,ST8SIA1,STK17B,TBX21,TCEAL9,TNFRSF8,VIPR2,ZBP1,ZBTB16,ZC3H12A | 278 (12) |
| PKD1 | -3.00e-02 | ion channel | NA | -1.52e+00 | 0.0e+00 | ACOX2,ALDH8A1,ARHGAP10,ATP1A1,ATP1B1,BHMT2,Ccl2,CDKN1A,CPN2,CXCL2,Hrg,JAKMIP2,JPH2,LOX,MYC,NEDD9,PCK1,PKNOX2,PRKCB,RADIL,SEMA4C,SERPINF2,SLC16A4,TRIM15 | 427 (17) |
| ITGA5 | -2.00e-02 | transmembrane receptor | NA | -1.52e+00 | 0.0e+00 | CDKN1A,COL2A1,FOS,IL12B,JUNB,MMP9,PLAUR,SELP | 377 (17) |
| ADA | 3.10e-01 | enzyme | NA | -1.54e+00 | 0.0e+00 | ADORA1,ADORA2B,CCL17,Ccl2,CCL24,CXCL2,CXCL3,MMP9,PLAT,SERPINE1,TIMP1 | 306 (17) |
| MAVS | 0.00e+00 | other | NA | -1.55e+00 | 0.0e+00 | BLK,Ccl2,CD83,CMPK2,CX3CR1,CXCL10,CXCL2,IFIT1,IL12B,IL1A,IRAK2,ISG15,JAK3,MERTK,MX1,OAS2,Oasl2,PLAUR,RSAD2,SLC11A1,SOCS3,SOX2,STAT1,TBX21,THBS1,USP18 | 236 (14) |
| ALK | -3.40e-01 | kinase | NA | -1.55e+00 | 0.0e+00 | BCL2L1,CD274,EGR3,FOS,GLI1,ID4,MYCN,NGFR,SERPINE1,SOX2,TNFRSF8,USP18 | 435 (18) |
| RET | 3.00e-02 | kinase | NA | -1.55e+00 | 0.0e+00 | ACTC1,ATF4,CCL2,Ccl2,CLDN5,CTSV,CXCR4,DUSP8,EDN3,FOS,LOX,MEOX2,MMP9,PLAUR,Pln,SELL,TGM1,TIMP3,UNC45B,WNT11 | 404 (19) |
| Calmodulin | NA | group | NA | -1.55e+00 | 0.0e+00 | CPNE5,DOC2B,F3,ICAM5,KDR,LGI3,LRRTM3,PHOSPHO1,RIMBP2,SEZ6,SYT1 | NA |
| SMO | -7.00e-01 | G-protein coupled receptor | NA | -1.56e+00 | 5.0e-02 | DIO1,GLI1,HSD11B2,MYC,PRSS35,S100A8,SOX18,SOX2,TGFA | NA |
| taurine | NA | chemical - endogenous mammalian | NA | -1.57e+00 | 0.0e+00 | ABCB11,ABCC2,Ccl2,CDO1,CPT1A,CPT1B,MMP9,PPARA,PTGS2,SLC6A6 | 531 (22) |
| IGF2BP1 | -7.00e-02 | translation regulator | NA | -1.57e+00 | 1.0e-02 | BCL11A,CDKN1A,GADD45A,GLI1,MYC,SERPINH1 | NA |
| spironolactone | NA | chemical drug | NA | -1.57e+00 | 0.0e+00 | ABCC2,CCL2,Ccl2,CD163,CDKN1A,CIDEA,CXCR4,DUSP1,EDN1,FASN,FKBP5,HCN4,HSD11B2,KCNMB1,LGALS3,LOX,PER1,PGF,PTGS2,SELL,Slco1a1,TIMP3 | 379 (19) |
| FBXO32 | 3.40e-01 | enzyme | NA | -1.58e+00 | 0.0e+00 | CKMT1A/CKMT1B,CXCL2,CXCL3,CXCL6,DKK2,GADD45A,GCLC,HPX,MYCN,MYOCD,PTGER3,PTGS2,TFPI2 | 196 (7) |
| quercetin | NA | chemical drug | NA | -1.58e+00 | 0.0e+00 | ABCC2,ADGRL2,AR,BCL2L1,BHLHE40,CCL2,Ccl2,CDKN1A,CXCL10,Cyp4a14,EDN1,FASN,FOS,FZD10,HIPK2,HMOX1,IER3,ISG15,KRT17,LCN2,MMP9,MRGPRF,MYC,NEDD9,ODC1,PLAUR,PON1,POR,PTGS2,RFX2,SELE,SNX19,TMC5,Tnfsf9,WNT5A,ZNF710,ZSCAN18 | 248 (10) |
| testosterone | NA | chemical - endogenous mammalian | NA | -1.58e+00 | 0.0e+00 | ANKRD1,ANXA3,AR,ARG2,ATP1B1,BCL2L1,BMP7,CDKN1A,CRP,CTSV,CYP26B1,CYP7B1,DDIT4,ERBB3,FOS,FOSL1,FOSL2,GADD45A,GNRH1,Gsta1,HCN4,HCRTR1,HDC,IL33,INHBA,IRS1,MAOA,Mt1,MX1,Mx2,NFKBIA,NGFR,NR5A2,ODC1,PPARA,PRKCB,PTGS2,SELP,SLC25A10,Slco1a1,STEAP2,TGFA,THBS1,TRIM63,TXNRD1,WNT5A | 688 (23) |
| TNFAIP3 | 2.10e-01 | enzyme | NA | -1.59e+00 | 1.0e-02 | BCL2L1,Ccl2,CXCL10,IL1A,MMP9,NFKBIA,SELE,SOCS3 | 338 (14) |
| MAFB | -4.10e-01 | transcription regulator | NA | -1.59e+00 | 0.0e+00 | ADGRE1,CCL2,CCL4,CD163,CD28,CXCL2,DLK1,ITGA2B,ITGB7,LGALS3,LGI3,MMP9,PCK1,PTGIR,RBP4,SPOCK1,TMEM119,ZNF189 | NA |
| IHH | -5.00e-01 | enzyme | NA | -1.59e+00 | 0.0e+00 | Acan,Ccl2,CD163,COL2A1,CPT1B,CXCL10,DHH,EREG,GLI1,IFITM5,KDR,PDK4,PLIN5,SHOX2,SMO,TMEM169 | NA |
| 22(R)-hydroxycholesterol | NA | chemical - endogenous mammalian | NA | -1.59e+00 | 2.0e-02 | ABCB11,ANGPTL3,FASN,HAS3,NR0B2,PON1 | NA |
| IFNL4 | NA | cytokine | NA | -1.60e+00 | 0.0e+00 | CXCL10,IFIT1,ISG15,MX1,OAS2,STAT1 | 190 (9) |
| PPARGC1B | -9.30e-01 | transcription regulator | NA | -1.60e+00 | 0.0e+00 | CIDEA,CPT1B,DIO2,ESRRG,FASN,HK2,PCK1,PDK4,PHOSPHO1,PPARGC1B,TRIM63 | 460 (20) |
| SP110 | -3.40e-01 | transcription regulator | NA | -1.61e+00 | 0.0e+00 | AQP3,ATF3,CXCL10,DAB2IP,EGR3,F3,IFIT1,IL4R,IL6R,MAOA,MX1,MYC,MYCN,NFIL3,STAT1,TGFBR3,TIMP1,TNFRSF21,TXNIP | NA |
| acetovanillone | NA | chemical drug | NA | -1.62e+00 | 0.0e+00 | CCL2,CXCL10,DUSP1,EDN1,F3,HMOX1,MMP9,OSGIN1,PTGS2,RYR2,SERPINE1 | 487 (19) |
| GATA1 | NA | transcription regulator | NA | -1.62e+00 | 0.0e+00 | AFF3,AQP1,ARHGAP4,BCL2L1,BMP6,BTG2,CCR3,CDKN1A,CIITA,CREM,EPB42,EZH2,F10,HIPK2,IKZF3,IL6R,ITGA2B,JUNB,KDR,LMO4,Meis1,MS4A1,MYC,MYCN,NFIL3,PLXNA1,Podxl,SCIN,SELP,SSBP3,TFR2 | 387 (20) |
| RORA | 1.70e-01 | ligand-dependent nuclear receptor | NA | -1.62e+00 | 0.0e+00 | ATP1B1,Ccl2,CCL24,CCL4,CCR6,CDKN1A,CLCA1,CXCL10,Cyp3a25 (includes others),CYP46A1,Cyp4a14,CYP7B1,FABP3,FASN,GADD45A,GADD45B,KCNK5,LCN2,LPIN2,Mt1,MUC5B,NFKBIA,NOCT,PCK1,POR,PPP1R3C,PTGS2,RBFOX1,S100A8,SELENBP1,SLC30A10,Slco1a1,SOCS3 | 445 (18) |
| EOMES | -2.20e-01 | transcription regulator | NA | -1.63e+00 | 0.0e+00 | ACTC1,CAP2,CEMIP,CHRNA7,CRYM,CXCR4,FOXC1,GZMA,IL2RB,KDR,MAP2K6,MEOX1,PLXNA4,PRF1,RAB17,RND3,SOX2,TBX6,TFPI2,TNFSF10 | NA |
| Ptprd | NA | phosphatase | NA | -1.63e+00 | 0.0e+00 | CCL2,Ccl2,CDKN1A,CEBPD,GADD45G,MYC | 242 (7) |
| immethridine | NA | chemical reagent | NA | -1.63e+00 | 0.0e+00 | Ccl2,CD14,CXCL3,FGA,LCN2,SOCS3 | NA |
| histone deacetylase | NA | complex | NA | -1.63e+00 | 1.0e-02 | CXCR4,IL24,JUNB,MMP9,PER1,PLAT,THBS1 | 539 (20) |
| SFTPC | 2.70e-01 | other | NA | -1.63e+00 | 1.0e-02 | ATF4,CDKN1A,CLDN4,KRT7,LGALS3,SFTPB | NA |
| PAK2 | -4.00e-02 | kinase | NA | -1.63e+00 | 2.0e-02 | CD40LG,CD69,DUSP1,GADD45A,PLAUR,ZEB2 | NA |
| ZNF106 | 7.00e-02 | other | NA | -1.63e+00 | 3.0e-02 | ACTC1,CXCL10,LGALS3,S100A8,SLC11A1,TNFRSF12A | NA |
| ATP2B2 | -1.80e-01 | transporter | NA | -1.63e+00 | 3.0e-02 | CDKN1A,GADD45A,HIPK2,LOXL1,NUPR1,ZBP1 | NA |
| WNT5A | -8.40e-01 | cytokine | NA | -1.64e+00 | 0.0e+00 | ABCB1,BCL2L1,BMP3,BMP6,BMPER,BTG2,CCL19,CCL2,CD14,CLDN4,COL2A1,CXCL10,CXCL2,CXCL6,CXCR4,DAB2IP,DKK2,DLL1,DOK2,EPHA4,EREG,ERN1,HMOX1,IL12B,IL1A,ITGB7,LAG3,MMP9,MYC,NR0B2,PGF,PKN1,PTGS2,ROR2,SDC4,SOCS3,STAMBPL1,STAT1,SYT1,TLR5,TNFSF10,ZEB2 | 491 (19) |
| PTPN11 | 2.40e-01 | phosphatase | NA | -1.64e+00 | 0.0e+00 | ABL1,BCL2L1,CD14,CDKN1A,CSF3R,FASN,FOS,ISG15,KDR,PLAUR,Pln,SFTPB,SOCS3,SOX7,TP73 | 414 (21) |
| 1,25-dihydroxyvitamin D | NA | chemical drug | NA | -1.64e+00 | 1.0e-02 | CCR10,CUBN,FGFR4,GLUL,MYC,PTPRC,SLC7A5,Tlr12,TLR5 | 369 (7) |
| EBF1 | -2.60e-01 | transcription regulator | NA | -1.65e+00 | 0.0e+00 | CBLB,CCL24,CCR9,CD19,CD28,CD79A,CD79B,CXCL10,FASN,FCER2,HK2,IL12B,IRS1,LCK,MKNK2,MYC,NFIL3,PAX5,PHKG1,PPP1R3C,SOCS3,STAT1 | 458 (19) |
| cytarabine | NA | chemical drug | NA | -1.66e+00 | 0.0e+00 | ADGRE5,CD180,CD274,CD69,CDKN1A,GADD45A,GZMB,LTB,MCC,PRF1,SESN1,SESN2,THRB,TNFRSF13C | 445 (20) |
| BAPTA | NA | chemical reagent | NA | -1.66e+00 | 0.0e+00 | CLDN4,FOS,FOSL1,JUNB,MMP9,PTGS2,SELP | 419 (17) |
| CNOT3 | 2.10e-01 | other | NA | -1.66e+00 | 0.0e+00 | CDKN1A,CPT1B,MYC,PAX5,PDK4,SOAT1 | NA |
| SB 290157 | NA | chemical reagent | NA | -1.66e+00 | 0.0e+00 | ADGRE1,C3AR1,CXCL2,CXCL3,PTGS2,THBS1 | 491 (16) |
| ZNF768 | -2.70e-01 | other | NA | -1.66e+00 | 0.0e+00 | AURKB,BTG2,CCL2,EZH2,GADD45A,SERPINE1 | 337 (7) |
| SERPINA1 | -5.80e-01 | other | NA | -1.66e+00 | 0.0e+00 | ATF4,CCL2,COL2A1,CR2,CX3CR1,FCER2,IL1A,RGS16 | 427 (12) |
| KN 93 | NA | chemical drug | NA | -1.66e+00 | 2.0e-02 | CD83,CXCL2,CXCL3,FOS,SELE,SELP | NA |
| HBB | 3.70e-01 | transporter | NA | -1.67e+00 | 0.0e+00 | CCL2,Ccl2,CCL4,CREB1,CXCL10,CXCL2,CXCL3,CXCL6,CYSLTR1,IFI44,IL12B,IL1A,IL24,LIF,LTA,MMP9,OAS2,PTGS2,SERPINE1,STAT1,TLR5 | 498 (18) |
| SAHM1 | NA | chemical reagent | NA | -1.67e+00 | 0.0e+00 | ABLIM1,BHLHE40,CR2,DDIT4,HK2,MYC,P4HA1,PFKFB3,ZBED3 | NA |
| 1,1-diarylethylene-diammonium derivative | NA | chemical reagent | NA | -1.67e+00 | 0.0e+00 | AURKB,CCL2,CDKN1A,IFI44,IFIT1,ISG15,METTL7B,OAS2,STAT1 | NA |
| benzyl isothiocyanate | NA | chemical - endogenous non-mammalian | NA | -1.67e+00 | 4.0e-02 | BCL2L1,FOS,MYC,PTGS2,SELE,SERPINE1 | NA |
| S100A4 | 8.00e-02 | other | NA | -1.67e+00 | 0.0e+00 | CCL19,CCL24,CDKN1A,CXCL3,MMP9,S100A8,THBS1,TIMP1 | 415 (20) |
| ARHGAP31 | 4.20e-01 | other | NA | -1.67e+00 | 1.0e-02 | BMP2,BMP7,GADD45B,PKP1,TGFBR3,ZEB2 | NA |
| CISH | 3.20e-01 | other | NA | -1.67e+00 | 0.0e+00 | BCL2L1,CA4,CCL4,CD101,CD14,CSF3R,CXCL10,CXCL3,EDN1,HDC,HMOX1,IFRD1,IL1A,LTA,MMP8,MYC,MYCN,PLAUR,PRF1,PTGS2,Retnlg,RGCC,SPHK1,TBX21 | 405 (18) |
| SGK1 | 5.00e-01 | kinase | NA | -1.68e+00 | 1.0e-02 | CDKN1A,IL12B,KCNA2,KCNA3,KCNA5,LIF,SLC38A3,SLC5A1,SMO | 304 (12) |
| HFE | 1.20e-01 | transmembrane receptor | NA | -1.68e+00 | 0.0e+00 | BHLHE40,BMP6,CPA2,CRELD2,CTRC,CYP26B1,Cyp4a14,DIO1,DUSP1,GADD45G,IL6R,ITIH4,LCN2,LPIN1,MOXD1,Mt1,PPP1R3C,RGS16,SOCS3,TFR2 | 105 (5) |
| EGLN | NA | group | NA | -1.69e+00 | 0.0e+00 | ANGPTL3,BCL11B,CCL2,Ccl2,CCL28,FOSL2,FSTL3,FTL,HK2,LCN2,MAP3K8,MYOCD,PEX11A,RAB20,SELENBP1,SERPINE1,SLC16A3,TNFAIP6,Tnfsf9 | 329 (9) |
| MYB | NA | transcription regulator | NA | -1.70e+00 | 0.0e+00 | ACAP1,BANK1,BCL2L1,BHLHE40,CARNS1,Ccl2,CCNA1,CD14,CXCL2,CXCL6,CXCR4,EZH2,GFI1,GIMAP7,HK2,IKBKE,IL1A,ITGA2B,KDR,LCN2,LIF,METTL7B,MYC,NEDD9,PTGS2,RGCC,SDC4,SLC16A3,SLC16A4,SOCS2,SOX2,SPHK1,TNFRSF13C,ZC3H12A | 430 (15) |
| 3M-002 | NA | chemical reagent | NA | -1.70e+00 | 0.0e+00 | ACAP1,ACTC1,BANK1,BCL2A1,BMX,CCL4,CD69,CD79A,CD83,CXCL10,CXCL3,DIO2,FCMR,FOSL1,IFI44,IL12B,IRF4,LRRC34,LTA,Milr1,MLPH,MYLK3,PTGS2,SPRED3,TNFSF10,TXNIP | 350 (16) |
| AZGP1 | -7.40e-01 | transporter | NA | -1.71e+00 | 0.0e+00 | AZGP1,BCL2L1,HK2,MYC,PNPLA2,TRIM63 | 473 (18) |
| Brd4 | NA | kinase | NA | -1.71e+00 | 0.0e+00 | ADGRG5,APCS,ATP8B4,GPR174,GPR55,H2-T24,HK2,IL12B,IL1A,ITGB7,KDR,LCK,LGALS3,LOX,LY86,MKNK2,MYC,PLAT,PPARGC1B,SELE,SELL,SOX2,SPON2,TIMP1,TNFSF10,TNFSF8 | 495 (23) |
| NAE1 | -1.20e-01 | enzyme | NA | -1.72e+00 | 1.0e-02 | AURKB,CCL2,CDKN1A,SFN | 350 (10) |
| SOX10 | -6.00e-01 | transcription regulator | NA | -1.72e+00 | 0.0e+00 | CD274,CDKN1A,DHH,ERBB3,FOS,GAS7,GZMB,IRF4,NGFR | NA |
| FKBP10 | 6.30e-01 | enzyme | NA | -1.73e+00 | 0.0e+00 | ADAMTS4,C1QTNF1,CCL17,COL2A1,CRISPLD2,GLI1,INHBA,PTGS2,SERPINE1,SPHK1,TIMP1,TNFAIP6 | NA |
| BTG2 | 6.00e-01 | transcription regulator | NA | -1.73e+00 | 0.0e+00 | BTG2,CCL2,CXCL2,CXCL3,HMOX1,IL1A,SERPINE1,TIMP1 | 498 (19) |
| COMMD1 | -2.20e-01 | transporter | NA | -1.73e+00 | 1.0e-02 | DDIT4,HK2,NFKBIA,PFKFB3,STAT1 | 311 (7) |
| tyrphostin AG 1478 | NA | chemical drug | NA | -1.74e+00 | 0.0e+00 | BCL2L1,CCL17,CCL2,CDKN1A,CXCR4,EDN1,F3,FOS,MMP9,PTGS2,PTX3,SPHK1,TFPI2,TNFAIP6 | 434 (17) |
| CTCF | -3.20e-01 | transcription regulator | NA | -1.74e+00 | 0.0e+00 | CCL17,Ccl2,CD14,CD274,CD83,CDKN1A,CXCL10,CXCR4,H2-Eb2,MUC5B,MYC,MYCN,PCDHA4,PCDHB2,Pcdhb6,PTGS2,TNFRSF12A,ZBTB16 | 527 (21) |
| PRKAA2 | -3.80e-01 | kinase | NA | -1.74e+00 | 2.0e-02 | ALB,CDKN1A,CIDEA,ERN1,FASN,IFI44,IL22RA1,KCNA2,LMO4,MMP9,NFKBIA,PTPRN,SOCS3,TXNIP | NA |
| IL7 | -2.70e-01 | cytokine | NA | -1.74e+00 | 0.0e+00 | BCL2L1,BTLA,CBLB,CCL2,Ccl2,CCL4,CCR9,CD19,CD274,CD3G,CD69,CD8A,CDKN1A,CXCL2,CXCL3,CXCR4,GFI1,IL24,ITGB7,JAK3,LIF,LTA,LTB,MAPKAPK3,MMP9,MX1,MYC,PAX5,PIK3IP1,RGS16,SELL,SOCS3,TNFSF10,TNFSF8,UPP1 | 382 (17) |
| SCD | 3.50e-01 | enzyme | NA | -1.74e+00 | 0.0e+00 | ADH1C,AR,ATF3,Ccl2,CPT1A,CPT1B,CXCL10,CXCL3,CXCL6,DIO1,DIO2,FASN,FOS,G0S2,GADD45A,KRT17,LCN2,LPIN1,LPIN2,MC5R,PCK1,PDK4,PEMT,PNPLA2,PPARA,PPARGC1B,S100A8,SGPP2,SOCS3,TGFA,TGM1,THBS1,THRB,TMEM26 | 525 (20) |
| TNFSF15 | -1.50e-01 | cytokine | NA | -1.75e+00 | 1.0e-02 | CD83,CXCL2,GZMB,IL2RB,Klrk1,MMP9,TBX21 | NA |
| IgG | NA | complex | NA | -1.75e+00 | 0.0e+00 | ADGRE1,AOC1,ATP1B1,BCL2L1,BHLHE40,CCL2,Ccl2,CCL4,CCR6,CD274,CD69,CD83,CDKN1A,CEBPD,CLDN4,CLDN5,CPT1A,CXCL10,DUSP1,EDN1,EGR3,FGFBP1,FOSL2,GADD45B,IL12B,IL1R2,IL6R,INHBA,IRF4,ISG15,JUNB,LCN2,LGALS3,LIF,MAP3K8,MMP9,MS4A1,MYC,NFKBIA,PLAUR,PPARA,PPL,PTGS2,RND3,SDC4,SERPINE1,STAT1,TBX21,THBS1,TNFRSF13C,TNFRSF18,TNFSF8,TRIM16,UBC,ZFP36 | 477 (15) |
| GLI1 | -6.80e-01 | transcription regulator | NA | -1.75e+00 | 0.0e+00 | ATF3,BCL2A1,BCL2L1,CA12,CAPRIN2,Ccl2,CDKN1A,CEP70,CMPK2,CNTRL,COL2A1,CSRNP1,DIO2,EGR3,ENDOD1,FOS,GADD45B,GATA5,GLI1,IER3,IL1R2,IL33,IRS1,KLF12,KRT80,LIF,MAFF,MMP9,MYCN,NKX2-8,PDK4,PGM2L1,PLAUR,PTGS2,SAT1,SDC4,SELENBP1,SERTAD4,SESN1,SGPP2,SIX4,SLC16A5,SLC16A9,SOCS2,SOCS3,SOX18,SOX2,SYTL2,TGFBR3,TIMP1,TIMP3,TNFRSF12A,TNS4,TRIM15,WNT5A,ZFP36 | 472 (21) |
| HDAC5 | -3.20e-01 | transcription regulator | NA | -1.76e+00 | 2.0e-02 | CD27,CDKN1A,CPT1A,CPT1B,DRP2,HK2,MYC,MYCN,PPARA,SIX1 | NA |
| NCOA5 | -2.50e-01 | other | NA | -1.76e+00 | 0.0e+00 | ARRDC3,Ccl2,CDKN1A,CFAP54,Clec2e/Clec2h,CXCL2,GADD45G,MYC,POU2AF1 | NA |
| FOXC2 | -6.50e-01 | transcription regulator | NA | -1.76e+00 | 1.0e-02 | COL2A1,CXCR4,DLL1,IRS1,KDR,MMP9,PPARA,PTGS2,SYT6,WDR72,WNT5A | NA |
| Klrk1 | -7.00e-01 | transmembrane receptor | NA | -1.77e+00 | 0.0e+00 | CCL4,GZMA,Klrc2/Klrc3,KLRD1,LAG3,PRF1,SLA2,STAT1,TBX21,XDH | 316 (7) |
| bexarotene | NA | chemical drug | NA | -1.78e+00 | 0.0e+00 | BCL11B,BMP6,BMP7,CCL2,Ccl2,CTSH,DACH1,DDIT4,DLK1,DUSP1,EGR3,EPHA2,IL2RB,KRT17,MAFF,MAP3K8,Meis1,MERTK,MMP9,Nes,NGFR,ODC1,PLAT,PLAUR,PTGS2,PTPRO,SLC7A1,SLC7A5,TGFA | 544 (20) |
| Interferon alpha | NA | group | NA | -1.78e+00 | 0.0e+00 | ADAMTS1,ANXA3,AQP3,ATF3,BCL2A1,BCL2L1,BTG2,C3AR1,CBLB,CCL19,CCL2,CCNA1,CCR3,CD274,CD69,CD83,CD8A,CDKN1A,CIITA,CRELD2,CXCL10,CXCL2,CXCL3,DDIT4,EDEM1,EZH2,F3,FASN,FMO3,FOS,FOSL2,GBP2,GBP5,GCLC,GIMAP4,GLI1,GZMB,HMOX1,IFI44,IFI44L,IFIT1,IFITM2,IKBKE,IL12B,IL21R,IL2RB,IL4R,IL6R,IRF4,ISG15,KRT17,LCK,LGALS3,LIF,LOXL1,MERTK,MX1,MYC,NFIL3,NFKBIA,OAS2,Oasl2,PBK,PLAT,PLAUR,PRF1,PTGS2,RNF213,RSAD2,SAT1,SERPINB1,SGSM3,SLC5A1,SOCS2,SOCS3,STAP1,STAT1,TBX21,TGM1,TNFSF10,TNFSF18,TPBG,TRIL,UBA7,USP18,ZBP1 | 424 (16) |
| ZFP36 | 9.40e-01 | transcription regulator | NA | -1.79e+00 | 0.0e+00 | CDKN1A,CXCL2,CXCL3,FOS,FOSL1,IER3,IL12B,IL1A,LCN2,NFKBIA,PBK,PLAUR,PTGS2,S100A8,ZFP36 | 434 (13) |
| GATA4 | -6.00e-01 | transcription regulator | NA | -1.80e+00 | 0.0e+00 | ACTC1,ADORA1,ANKRD1,BCL2L1,CA12,CCL2,CCL4,CTHRC1,CXCL2,CXCL6,CXCR4,DIO2,EDN1,Elf5,F10,FOS,INHBA,KCNA5,KRT17,KRT7,LCN2,MYC,NR5A2,PDHA1,PDLIM3,Pln,PPL,PTGS2,RYR2,TIMP1 | 417 (17) |
| EBI3 | -1.60e-01 | cytokine | NA | -1.80e+00 | 0.0e+00 | CCL24,CCR6,CD274,CIITA,FOS,GADD45G,GBP2,HLA-DOB,LAG3,MX1,MYC,STAT1,TBX21,TNFSF10 | 388 (16) |
| TINCR | NA | other | NA | -1.80e+00 | 0.0e+00 | ATF4,EPHA2,FTL,MMP9,PDGFB,S100A8 | 218 (7) |
| herbimycin | NA | chemical drug | NA | -1.81e+00 | 0.0e+00 | BCL2L1,CXCR4,DUSP1,FOS,IRS1,JUNB,MMP9,PTGS2,SERPINE1 | 448 (19) |
| STAT5B | 3.00e-02 | transcription regulator | NA | -1.84e+00 | 0.0e+00 | ABCB1,Acot1,ACTC1,ANKRD1,AR,BAIAP2,BCL2L1,C9,CD27,CDKN1A,CDO1,CIDEA,CIRBP,CYP26B1,DUSP1,FAM89A,FOS,FOSL2,G0S2,GABARAPL1,GADD45A,GADD45B,GJB1,GLUL,H2-T22,IFITM2,IL24,IL2RB,KIF9,LTA,LTB,MOXD1,MYC,MYCN,MYCT1,Oasl2,PAX5,Pcp4l1,PDK4,PIK3IP1,POU2F2,PPP1R3C,PROCR,SLC16A5,SLC39A10,SLC47A1,Slco1a1,SOCS2,SOCS3,STAMBPL1,SYBU,TNFRSF14,TREM3,UBA7,ZFP36 | 559 (23) |
| metformin | NA | chemical drug | NA | -1.84e+00 | 0.0e+00 | ABCB1,APOB,ARRDC3,ATF3,ATF4,BMP2,CCL2,CCR3,CD274,CDKN1A,CFAP54,Clec2e/Clec2h,CRP,DDIT4,ENO3,ERN1,F3,FASN,FOS,GADD45B,GADD45G,GRB14,HMOX1,IFI44,IL22RA1,INHBA,IRS1,MMP9,MUC5B,MX1,MYC,NFKBIA,NR0B2,PCK1,PHKG1,POU2AF1,PPARGC1B,PROCR,PTGS2,SERPINE1,SOCS3,Tnfsf9,TXNIP | 532 (19) |
| PTPRR | -3.50e-01 | phosphatase | NA | -1.85e+00 | 3.2e-01 | BTG2,FOS,FOSL1,IFITM2,PROCR,TELO2,TMEM178A | NA |
| PP2/AG1879 tyrosine kinase inhibitor | NA | chemical drug | NA | -1.87e+00 | 4.0e-02 | CCL2,CDKN1A,DUSP1,EDN1,FOS,HMOX1,PER1,PTGS2,SERPINE1 | NA |
| CD274 | -5.90e-01 | enzyme | NA | -1.87e+00 | 0.0e+00 | ATF4,BCL2L1,CD274,CD69,CXCL2,ERN1,GZMB,IFIT1,MX1,OAS2,PRF1,PTGS2,TNFSF10 | 410 (20) |
| JAK1/2 | NA | group | NA | -1.88e+00 | 0.0e+00 | BAIAP2,BCL11B,CA12,CCL2,Ccl2,CD69,CIITA,FAM107A,FAM81A,GBP2,GBP5,ICAM5,Ifgga2l1/RGD1309362,ISG15,KCNF1,KCNG1,MX1,Mx2,Nrgn,PRKCG,RPRML,RSAD2,WIPF3 | 268 (11) |
| mir-30 | NA | microRNA | NA | -1.88e+00 | 1.0e-02 | AR,Ccl2,CDKN1A,GADD45A,IL12B,NEDD4L,SERPINE1,SNAP23 | 543 (17) |
| SMARCA5 | -6.00e-02 | transcription regulator | NA | -1.89e+00 | 0.0e+00 | ATP2B4,ATP8B4,BLK,CDKN1A,ENC1,EPHA2,FKBP5,H2-T22,IFITM2,IKZF3,KBTBD11,OSGIN1,PLXND1,Pmaip1,RASGRP4,SERPINB1,TDRD5,THEMIS | NA |
| molybdenum disulfide | NA | chemical reagent | NA | -1.89e+00 | 0.0e+00 | CCL2,EFHD1,EXTL1,HAPLN3,HMOX1,IFI44,IFIT1,ITGA7,LAMA5,LIMS2,LRRC17,MLPH,RFX8,STK38L,TFPI2,THBS1,TINAGL1,TMEM171 | NA |
| prazosin | NA | chemical drug | NA | -1.89e+00 | 0.0e+00 | CCL2,DIO2,DUSP1,FOS,GNRH1,MYC,PER1,Sik1 | 419 (18) |
| EIF4B | 2.90e-01 | translation regulator | NA | -1.89e+00 | 0.0e+00 | CXCL3,IL1R2,ISG15,Klrc2/Klrc3,KLRD1,PRF1,SLC6A12 | NA |
| HOXB13 | NA | transcription regulator | NA | -1.89e+00 | 0.0e+00 | AR,CDKN1A,EPHA4,LRRN1,MYC,NFKBIA,SLC30A10 | 438 (12) |
| pyridaben | NA | chemical toxicant | NA | -1.89e+00 | 3.0e-02 | CCL19,CEBPD,INHBA,KCNA2,MAPK15,STON2,TBCK | NA |
| RABL6 | 1.00e-01 | other | NA | -1.89e+00 | 7.0e-02 | AURKB,BTG2,EZH2,HMOX1,MYC,PBK,SERPINH1 | NA |
| WBP2 | -1.00e-02 | transcription regulator | NA | -1.89e+00 | 1.0e+00 | APOB,AQP3,CXCL2,CXCL3,FCMR,PTGS2,SLC16A3 | NA |
| GW 4064 | NA | chemical toxicant | NA | -1.90e+00 | 0.0e+00 | ABCB1,ABCB11,ABCC2,BAAT,FGA,MMP9,NR0B2,PCK1,PDK4,PON1,PPARA,SLC10A1,Slco1a1 | 382 (20) |
| IFN Beta | NA | group | NA | -1.90e+00 | 0.0e+00 | AADAT,ATF3,BCL2L1,BTG2,C3AR1,CCL2,Ccl2,CD163,CD22,CD274,CD69,CD79A,CD83,CDKN1A,CEBPD,CMPK2,CXCL10,DUSP1,EREG,FKBP5,IFI44,IFIT1,IL1A,IL24,ISG15,KYNU,MMP9,MX1,Mx2,MYC,NELL2,OAS2,RSAD2,SERPINE1,SPHK1,STAT1,THBS1,TLR5,TNFSF10,TNFSF18,TRIM14,TXNRD1,USP18,ZBP1 | 338 (14) |
| HIC1 | -5.50e-01 | transcription regulator | NA | -1.91e+00 | 0.0e+00 | ADORA2B,ANO2,CA12,CDKN1A,CDO1,CYP7B1,EPHA2,ID4,INHBA,KAZN,KCNJ6,LCN2,LIF,MCAM,TRIM16 | NA |
| E2f | NA | group | NA | -1.91e+00 | 5.3e-01 | CCNA1,DDX11,EFHC1,MYC,MYCN,SERPINE1,TGM1 | NA |
| mir-96 | NA | microRNA | NA | -1.91e+00 | 1.0e-02 | CMPK2,IFI44L,IFIT1,IRS1,ISG15,OAS2,RSAD2 | NA |
| CHKB | 2.30e-01 | kinase | NA | -1.91e+00 | 1.0e-02 | CPT1B,CREB1,FABP3,HCN4,PPARA,PPARGC1B,TXNIP | NA |
| C3AR1 | -7.40e-01 | G-protein coupled receptor | NA | -1.91e+00 | 2.0e-02 | Ccl2,CCL4,CD28,CXCL10,GULP1,KRT17,SERPINE1 | NA |
| garcinol | NA | chemical - endogenous non-mammalian | NA | -1.91e+00 | 2.2e-01 | BCL2L1,BRPF1,CCNA1,GTF3A,GULP1,PLAT,ZFP36 | NA |
| MAP4K4 | -2.50e-01 | kinase | NA | -1.91e+00 | 4.6e-01 | CBLB,FASN,GLUL,H6PD,HYAL2,PEX11A,PNPLA3 | NA |
| TBX2 | NA | transcription regulator | NA | -1.91e+00 | 1.2e-01 | ATF3,AURKB,BHLHE40,CDKN1A,ELK3,EZH2,NFIL3 | NA |
| TBX5 | -6.00e-02 | transcription regulator | NA | -1.92e+00 | 0.0e+00 | ACTC1,ANKRD1,CCL2,CCL4,CXCL2,CXCL6,CXCR4,KCNA5,PDLIM3,Pln,PTGS2,RYR2,TNFSF8 | 459 (21) |
| Ro31-8220 | NA | chemical drug | NA | -1.92e+00 | 0.0e+00 | BCL2L1,CCL2,CDKN1A,DUSP1,FSTL3,HMOX1,Mt1,PTGS2,SERPINE1,TNFSF10 | 397 (21) |
| HNF4A | -9.00e-01 | transcription regulator | NA | -1.93e+00 | 1.0e-02 | ABCB11,ABCC2,Acot1,ACOX2,ALB,ALDH8A1,AOC1,APCS,APOB,AQP1,AQP3,ARG2,ATF4,BAAT,BCL2L1,BMP7,Btnl4/Btnl6,CBS/LOC102724560,CCDC170,CDHR1,CDKN1A,CEBPD,Clec2e/Clec2h,COQ10B,CPA2,CPB2,CPT1A,CPT1B,CRP,CXCL3,CYP7B1,DACH1,DCLRE1B,DISP2,DMC1,DNAJC28,DUSP19,EHD3,Elf5,ELL,ENC1,EPHA2,EREG,F9,FGA,FKBP10,FMO3,FOSL2,G0S2,GADD45B,GADD45G,GJB1,GJB2,GPR37,GRB14,GRHL1,GRIN2D,HNF4A,HPX,HSD17B2,HSPA4L,HUNK,HYAL3,IFITM2,IGSF8,IL22RA1,IL2RB,INHBA,ITIH4,JUNB,KCNJ11,KCNJ12,KIF9,KLF15,KRT17,KRT7,LCN2,LGALS3,MAOA,MAOB,MRO,Mt1,MYC,NFYA,NR0B2,NR5A2,NUDT5,OSMR,P2RY14,PCDH20,PCK1,PDK4,PEMT,PLG,PNPLA3,PON1,POR,PPARA,PPL,PPP1R14D,PPP1R3C,PSAT1,PTPRN,PURG,PYGO1,RASL12,RASSF1,RNF152,RPS6KA6,RSAD2,SELP,SEMA7A,SERPINE1,SESN2,SLC10A1,SLC26A1,SLC43A1,Slco1a1,SNAP23,SSTR4,STAT1,SYBU,TACO1,TBC1D16,TBCK,TFR2,TIMP3,TLE3,TMTC4,TNFAIP6,TRIM15,TRMT1L,TSNAXIP1,TTC22,TXNIP,TXNRD1,WDCP,WNT11,XPO1,ZBED3,ZBTB37,ZFP36,ZNF189,ZSCAN18 | NA |
| MDM4 | -2.60e-01 | transcription regulator | NA | -1.93e+00 | 1.0e-02 | CDKN1A,HIPK2,LGALS3,NKD2,TP73,WNT7A | 396 (13) |
| ANGPTL4 | 4.90e-01 | other | NA | -1.93e+00 | 0.0e+00 | CXCL3,ERN1,FASN,LPIN1,STAT1 | 330 (11) |
| mir-183 | NA | microRNA | NA | -1.94e+00 | 1.0e-02 | CMPK2,IFI44L,IFIT1,IRS1,ISG15,OAS2,RSAD2,STAT1 | 228 (12) |
| ATG16L1 | 1.50e-01 | enzyme | NA | -1.94e+00 | 1.0e-02 | CXCL2,IL1A,IRS1,NFKBIA | 422 (16) |
| BACH1 | 2.90e-01 | transcription regulator | NA | -1.94e+00 | 3.0e-02 | CXCR4,DUSP1,FTL,GCLC,HIF3A,HK2,HMOX1,PDK4 | NA |
| ERBB3 | 8.20e-01 | kinase | NA | -1.94e+00 | 5.0e-02 | CDKN1A,CXCR4,DUSP1,ERBB3,F3,HMOX1,PTGS2,SERPINE1,SOCS3,THBS1,TIMP3 | NA |
| SOX5 | -6.00e-02 | transcription regulator | NA | -1.94e+00 | 0.0e+00 | Acan,BMP6,COL2A1,SPAG6 | NA |
| GFI1B | -1.40e-01 | transcription regulator | NA | -1.95e+00 | 1.0e-02 | BCL2L1,CDKN1A,MYC,SOCS3,TGFBR3 | 156 (5) |
| ITK | -4.00e-01 | kinase | NA | -1.95e+00 | 0.0e+00 | ARL4D,CCR10,CX3CR1,FOS,IL2RB,Klrb1f,Klrc2/Klrc3,KLRD1,Klrk1,LAT2,MYC,PRF1,PRKCB,TBX21,TNFSF10,XCL1,ZBTB16 | 486 (19) |
| anakinra | NA | biologic drug | NA | -1.96e+00 | 0.0e+00 | ABCC2,CCL2,CCL4,EDN1,GRINA,HMOX1,IL1A,PTGS2,SELE,SLC10A1,Slco1a1 | 435 (18) |
| vitamin E | NA | chemical drug | NA | -1.96e+00 | 0.0e+00 | BCL2L1,CCL2,CDKN1A,COL2A1,F3,IL1A,NFIL3,PLAT,PPARA,PTGS2,SELP,SERPINE1 | 411 (18) |
| miR-23a-3p (and other miRNAs w/seed UCACAUU) | NA | mature microRNA | NA | -1.96e+00 | 9.0e-02 | HK2,IL6R,SELE,TRIM63 | NA |
| L-lysine | NA | chemical - endogenous mammalian | NA | -1.96e+00 | 1.0e-02 | ALB,ATF4,CXCL2,DDIT4 | 397 (13) |
| ibuprofen | NA | chemical drug | NA | -1.96e+00 | 8.0e-02 | MMP9,NGFR,PTGS2,PTPRC,TNFRSF21 | NA |
| SERCA | NA | group | NA | -1.96e+00 | 0.0e+00 | BTG2,FOSL1,MYC,ZFP36 | 342 (11) |
| COPS5 | -1.40e-01 | transcription regulator | NA | -1.96e+00 | 2.0e-02 | AK1,ATF3,AURKB,CDKN1A,DDIT4,ELL,EPHA2,HMOX1,HSPA4L,IL1A,MKNK2,MYC,ODC1,PBK,SAT1,SESN1,SLC7A5,SPHK1,TBRG4,TXNIP,UPP1 | NA |
| mir-154 | 0.00e+00 | microRNA | NA | -1.96e+00 | 4.0e-02 | ADAMTS1,ATF3,HMOX1,MYC,PLAUR | NA |
| KMT2D | -2.40e-01 | transcription regulator | NA | -1.97e+00 | 0.0e+00 | Acot1,ADCY5,ADGRG2,BVES,CA4,CCL2,CD274,CDCA7,CHST7,Eda,ENO3,FABP3,GJB2,GRHL1,KRT17,LCK,LOXL1,MEOX1,MMP9,NPR3,PPP2R2B,S100A8,SIX4,SMO,STBD1,TGM1,TOX3,XKRX,ZNF184 | 232 (7) |
| RCAN1 | NA | other | NA | -1.97e+00 | 1.3e-01 | F3,FOS,PTGS2,SELE | NA |
| SGPL1 | -1.00e-01 | enzyme | NA | -1.97e+00 | 0.0e+00 | ABCB1,BCL2L1,IFIT1,ISG15,MX1,PTGS2,SPNS2 | 401 (18) |
| DACH1 | -1.24e+00 | transcription regulator | NA | -1.97e+00 | 0.0e+00 | CDKN1A,CXCL3,FOS,PLAT,PTGS2,SERPINE1,SOCS3,SOX2 | 448 (19) |
| tempol | NA | chemical drug | NA | -1.97e+00 | 1.0e-02 | BCL2L1,CXCL2,F3,MMP9,PLAUR,PTGS2,SERPINE1 | 319 (16) |
| CD2 | -3.70e-01 | transmembrane receptor | NA | -1.97e+00 | 8.0e-02 | CD40LG,CD8A,PTPRC,SELL,STAT1 | NA |
| MTA3 | 2.30e-01 | transcription regulator | NA | -1.98e+00 | 0.0e+00 | ACTC1,CD19,CD79B,CIITA,MYC,ZEB2 | NA |
| triciribine | NA | chemical drug | NA | -1.98e+00 | 1.0e-02 | ATF3,Ccl2,CIDEA,CXCL3 | 217 (7) |
| DEK | 1.70e-01 | transcription regulator | NA | -1.98e+00 | 1.0e-02 | Ccl2,CDKN1A,CSF3R,NFKBIA | 365 (12) |
| SIRT3 | 5.00e-02 | enzyme | NA | -1.98e+00 | 3.7e-01 | Ccl2,CPT1A,DIO2,PPARA,SOX2 | NA |
| IFN Lambda | NA | group | NA | -1.98e+00 | 0.0e+00 | CXCL2,ISG15,OAS2,USP18 | 183 (9) |
| PDCD10 | 2.10e-01 | other | NA | -1.98e+00 | 1.0e-02 | F2RL1,PROCR,SERPINE1,THBS1 | NA |
| GAS2L3 | 1.20e-01 | other | NA | -1.98e+00 | 1.0e-02 | BTG2,CDKN1A,LIF,SAT1 | NA |
| NEDD4 | NA | enzyme | NA | -1.98e+00 | 2.0e-02 | CDKN1A,ERBB3,ERRFI1,MMP9 | NA |
| HMGN1 | 1.30e-01 | transcription regulator | NA | -1.98e+00 | 2.0e-02 | AZGP1,CHTF8,FGA,FOS,G0S2 | NA |
| ORAI1 | 5.00e-01 | ion channel | NA | -1.98e+00 | 2.0e-02 | CDKN1A,CXCL3,KDR,TBX21 | NA |
| PD 153035 | NA | chemical drug | NA | -1.98e+00 | 2.0e-02 | BCL2L1,CCL2,FOS,PTGS2 | NA |
| Mt2 | NA | other | NA | -1.98e+00 | 4.0e-02 | ATF3,FOS,MYC,SERPINE1 | NA |
| PTPRC | -7.10e-01 | phosphatase | NA | -1.98e+00 | 9.0e-02 | BCL2A1,CCL4,CCR3,PTPRCAP,SLFN12 | NA |
| ALDH2 | 2.80e-01 | enzyme | NA | -1.98e+00 | 1.2e-01 | ATF4,GCLC,PSAT1,SLC7A5 | NA |
| miR-125b-5p (and other miRNAs w/seed CCCUGAG) | NA | mature microRNA | NA | -1.99e+00 | 2.2e-01 | ADAMTS1,ANAPC16,Ccl2,ERBB3,HK2,IL6R,PCTP,SMO | NA |
| TOPBP1 | 1.20e-01 | other | NA | -1.99e+00 | 0.0e+00 | ABL1,CDKN1A,GADD45A,MYC,Pmaip1 | 443 (19) |
| RNA fragment | NA | chemical - endogenous mammalian | NA | -1.99e+00 | 1.0e-02 | IKBKE,IL12B,MYC,NFKBIA | NA |
| PSMB11 | -5.00e-02 | peptidase | NA | -2.00e+00 | 0.0e+00 | Ccl2,CD28,CLDN4,CTSV,CXCL3,CXCL6,GADD45A,GADD45B,HMOX1,ITGB7,LGALS3,Pmaip1,PRKCB,PTGS2,PTPRC,THBS1,TNFRSF12A,TNFRSF21,TNFRSF8,TNFSF10 | 301 (7) |
| IL37 | NA | cytokine | Inhibited | -2.00e+00 | 0.0e+00 | BMP2,CCL4,CXCL10,CXCL2,CXCL3,IL1A,TIMP1 | 331 (14) |
| GLIS2 | -5.20e-01 | transcription regulator | Inhibited | -2.00e+00 | 0.0e+00 | Ccl2,CCL28,CXCL10,CXCL3,IL12B,IL33,MGP,SERPINE1 | 372 (13) |
| RHOC | 3.20e-01 | enzyme | Inhibited | -2.00e+00 | 0.0e+00 | ATF3,CDKN1A,GLUL,NAT8L | NA |
| emactuzumab | NA | biologic drug | Inhibited | -2.00e+00 | 0.0e+00 | GBP4,IFIT1,ISG15,STAT1 | NA |
| JMF3086 | NA | chemical reagent | Inhibited | -2.00e+00 | 0.0e+00 | Ccl2,CXCL2,CXCL3,PTGS2 | 548 (19) |
| RPL22 | 1.90e-01 | translation regulator | Inhibited | -2.00e+00 | 0.0e+00 | ATF3,ATF4,CDKN1A,Pmaip1 | 320 (10) |
| latrunculin A | NA | chemical toxicant | Inhibited | -2.00e+00 | 0.0e+00 | CXCL10,CXCL2,IL12B,TRPV1 | 443 (20) |
| STS | 2.80e-01 | enzyme | Inhibited | -2.00e+00 | 1.0e-02 | ADGRE1,Ccl2,CEBPD,IRS1,Mt1,PNPLA2 | 367 (10) |
| IFNK | NA | cytokine | Inhibited | -2.00e+00 | 1.0e-02 | CD83,CXCL10,MX1,STAT1,ZBP1 | 475 (21) |
| RXFP2 | -1.40e-01 | G-protein coupled receptor | Inhibited | -2.00e+00 | 1.0e-02 | AR,DHH,SOX18,SOX7 | NA |
| finerenone | NA | chemical drug | Inhibited | -2.00e+00 | 1.0e-02 | DUSP1,LCN2,LGALS3,PER1 | NA |
| NOP2 | 1.70e-01 | other | Inhibited | -2.00e+00 | 1.0e-02 | CDKN1A,CKMT1A/CKMT1B,MAP1LC3B,SESN2 | NA |
| glutamyl-Se-methylselenocysteine | NA | chemical - endogenous mammalian | Inhibited | -2.00e+00 | 1.0e-02 | ATP1A1,GNAI2,PLAUR,TIMP3 | NA |
| fumonisin B1 | NA | chemical toxicant | Inhibited | -2.00e+00 | 3.0e-02 | ABCB1,LTB,PTGS2,TNFSF10 | NA |
| MLN120B | NA | chemical drug | Inhibited | -2.00e+00 | 4.0e-02 | Ccl2,CXCL2,CXCL6,PTGS2 | NA |
| creatine | NA | chemical - endogenous mammalian | Inhibited | -2.00e+00 | 4.0e-02 | CKMT1A/CKMT1B,CXCL10,CXCL2,CXCL3 | NA |
| SRSF2 | 3.20e-01 | transcription regulator | Inhibited | -2.00e+00 | 8.0e-02 | ATF4,AURKB,BAAT,PPARA,RYR2 | NA |
| TRIM28 | 1.20e-01 | transcription regulator | Inhibited | -2.00e+00 | 2.0e-01 | CCL4,CXCL10,CXCR4,SOX2,TP73,WNT5A | NA |
| Bvht | NA | other | Inhibited | -2.00e+00 | 1.0e+00 | ACTC1,KDR,Pln,UNC45B | NA |
| ARID3A | -1.60e-01 | transcription regulator | Inhibited | -2.00e+00 | 1.0e+00 | CYP2S1,LRRN1,PIPOX,SLC39A10 | NA |
| PP1 | NA | chemical drug | Inhibited | -2.00e+00 | 0.0e+00 | BCL2L1,CCNA1,CXCR4,FOS,HMOX1,IL1A,MYC,ODC1,PTGS2,SERPINE1 | 405 (16) |
| KLF2 | -1.80e-01 | transcription regulator | Inhibited | -2.02e+00 | 0.0e+00 | CCL2,Ccl2,CCL28,CCL4,CCR3,CD40LG,CDKN1A,CR2,CRP,CX3CR1,CXCL2,CXCL3,CXCR4,DLL1,EDN1,F2RL1,F3,GADD45A,GZMM,HYAL2,IL6R,ITGB7,JUNB,KDR,MYC,NFKBIA,PGF,PRF1,PTGS2,S1PR5,SELL,SERPINE1,STAT1,TBX21,TFPI2,THBS1,TIMP1,TNFRSF8,TNFSF10 | 412 (15) |
| KCNIP3 | 1.86e+00 | transcription regulator | Inhibited | -2.03e+00 | 0.0e+00 | ADORA2B,CD28,CHRNA7,CREM,EDEM1,FOS,FOSL2,PGLYRP1,PPARA,SOCS3,TNFAIP6,ZFP36 | 448 (16) |
| MEF2A | 2.80e-01 | transcription regulator | Inhibited | -2.05e+00 | 0.0e+00 | ACTC1,ARHGAP20,CD69,CPT1B,CXCL10,EDN1,ENO3,FOS,GBP2,IFI44,IL12B,ITGA7,MEOX2,Mx2,MYOCD,Oasl2,PKNOX2,RSAD2,SYT1,ZEB2 | 196 (7) |
| FXR ligand-FXR-Retinoic acid-RXRα | NA | complex | Inhibited | -2.05e+00 | 0.0e+00 | ABCB11,ABCC2,BAAT,FASN,NR0B2,NR5A2,PPARA | NA |
| N-acetyl-L-cysteine | NA | chemical drug | Inhibited | -2.06e+00 | 0.0e+00 | ABCB1,ADGRE1,ADORA2B,AQP1,AR,ATF4,ATP1A1,BCL2A1,BCL2L1,BMP2,CCL2,Ccl2,CD274,CDKN1A,CXCL10,CXCL3,CXCR4,DDIT4,DUSP1,EDN1,FASN,FOS,GCLC,GNAI2,GZMB,HDC,HK2,HMOX1,IL12B,IL1A,MAP1LC3B,MMP9,MYC,MYOCD,NFKBIA,OSGIN1,PLAUR,PTGS2,SELE,SELP,SERPINE1,TNFRSF8,TRIM63,TXNIP | 353 (13) |
| EBF4 | -6.00e-02 | transcription regulator | Inhibited | -2.06e+00 | 0.0e+00 | CDKN1A,GZMA,IL2RB,JAK3,KLRD1,PRF1,TBX21 | NA |
| Alpha catenin | NA | group | Inhibited | -2.07e+00 | 0.0e+00 | ADAMTS1,ADAMTS4,ADAMTS5,BCL2L1,CTSV,CXCL10,CXCL2,CXCL6,ELK3,EPGN,EREG,MMP9,MYC,NFKBIA,PTGS2,PTX3,S100A8,SELE,SOCS3,STEAP2,TIMP1,TNFAIP6,TNFRSF12A,ZEB2 | 412 (18) |
| SNAI2 | -5.50e-01 | transcription regulator | Inhibited | -2.08e+00 | 1.0e-02 | Acan,ANKRD1,AR,CDH15,CDKN1A,COL2A1,CXCR4,ID4,MMP9,MYBPH,SOX2 | 482 (24) |
| SNAI1 | -2.90e-01 | transcription regulator | Inhibited | -2.10e+00 | 0.0e+00 | Acan,ANKRD1,BCL2L1,CCL2,CDKN1A,CLDN11,CLDN4,COL2A1,F3,FASN,FOS,FOSL1,GLI1,HNF4A,ID4,KRT17,LIF,MMP9,PTGS2,PTX3,SERPINE1,SERPINH1,SLC28A3,SOX2,TGFBR3,ZEB2 | 509 (20) |
| FST | -3.40e-01 | other | Inhibited | -2.10e+00 | 1.0e-02 | BMP7,CIDEA,COL2A1,FABP3,GFI1,GNRH1,LIF,PLG,PPARGC1B,ZEB2 | 298 (7) |
| RNF31 | 1.80e-01 | enzyme | Inhibited | -2.11e+00 | 0.0e+00 | ADORA1,CCL17,CCL19,CCL2,Ccl2,CCL4,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,EGR3,IL1A,IL1R2,IL24,IL33,IL4R,IL6R,NR5A2 | 419 (13) |
| HOXA9 | NA | transcription regulator | Inhibited | -2.11e+00 | 0.0e+00 | CALCRL,CCL2,CCR9,CPB2,CREB1,CREM,EDNRA,GFI1,JUNB,KCNA3,LAT2,LY86,Meis1,MYC,Nrgn,PTPRC,PTPRCAP,S100A8,SDC4,SELE,SPNS2 | 225 (7) |
| HIVEP1 | 4.00e-02 | transcription regulator | Inhibited | -2.11e+00 | 0.0e+00 | CXCL2,IL1A,IL1R2,IL33,IRAK2,LTA,MAP3K8,NFKBIA,TGFA,TGFBR3,TLR5 | 409 (9) |
| RNY3 | NA | other | Inhibited | -2.12e+00 | 0.0e+00 | CXCL10,IFI44,IFI44L,IFIT1,ISG15,MX1,OAS2,RSAD2 | 395 (7) |
| lisinopril | NA | biologic drug | Inhibited | -2.12e+00 | 0.0e+00 | Ccl2,FOS,GBP2,KDR,MMP8,MMP9,Retnlg,S100A8 | 316 (9) |
| HDL-cholesterol | NA | complex | Inhibited | -2.12e+00 | 0.0e+00 | APCS,APOB,CREM,FOSL2,MMP9,NUPR1,RASGRP1,TRIM66 | NA |
| LAS1L | 1.80e-01 | other | Inhibited | -2.12e+00 | 2.0e-02 | BTG2,CDKN1A,CEMIP,CKMT1A/CKMT1B,CPT1A,MAP1LC3B,PEMT,SESN2 | NA |
| MGA | -2.70e-01 | transcription regulator | Inhibited | -2.12e+00 | 2.0e-02 | Acot1,BTG2,CXCL10,CYP2S1,KBTBD11,P4HA2,PPP1R1B,TCN2 | NA |
| TBX21 | -9.60e-01 | transcription regulator | Inhibited | -2.13e+00 | 0.0e+00 | CCL2,CCL4,CX3CR1,CXCL10,GZMA,GZMB,IL2RB,IL6R,KLRD1,Klrk1,LAG3,PRF1,SELL,TBX21,ZEB2 | 476 (19) |
| cardiotoxin | NA | chemical - other | Inhibited | -2.13e+00 | 0.0e+00 | CCL17,CCL2,Ccl2,CCL24,CCL4,CD180,CSF3R,CTSH,CTSV,CXCL10,CXCR4,DHH,DLL1,DOK2,FGF11,FNDC5,IL1A,IL33,IL4R,IL6R,INHBA,ITGB7,Klra2,LCN2,LIF,LTA,LY86,MERTK,MMP8,PDGFB,PLG,PTPRC,S100A8,SERPINE1,THBS1,TIMP1,TNFRSF14,TNFRSF18,TNFRSF8,TXNRD1 | NA |
| HOXA7 | NA | transcription regulator | Inhibited | -2.14e+00 | 0.0e+00 | CALCRL,EDNRA,KCNA3,LAT2,LY86,Nrgn,PTPRCAP,TGM1 | NA |
| TASL | NA | enzyme | Inhibited | -2.14e+00 | 0.0e+00 | BCL2A1,CCL2,CD274,GBP4,GBP5,IFIT1,TNFAIP6,USP18 | 154 (7) |
| SMARCB1 | NA | transcription regulator | Inhibited | -2.14e+00 | 0.0e+00 | ABCB1,ARHGAP4,ATP1B1,BMP2,CDKN1A,CRP,CXCR4,Cyp3a25 (includes others),Cyp4a14,DACH1,DMC1,F10,FOS,GFI1,GJB1,GJB2,IL12B,IL1A,MX1,MYC,PCK1,PDGFB,PGLYRP1,PLCL1,PPP1R3C,RND3,SYCE1,TBX21 | 506 (21) |
| FADD | -1.90e-01 | other | Inhibited | -2.14e+00 | 0.0e+00 | ARID5A,Ccl2,CDKN1A,CXCL10,CXCL2,CXCR4,FOS,GADD45B,JUNB,MMP9,Mx2,MYC,NFIL3,STAT1 | 422 (17) |
| BNIP3L | -1.30e-01 | other | Inhibited | -2.14e+00 | 0.0e+00 | BCL2L1,Ccl2,CD19,CD22,CD79B,GADD45A,HK2,IL2RB,LTA,LTB,MAP4K1,NFKBIA,PFKFB3 | 404 (16) |
| RNF187 | -7.00e-02 | enzyme | Inhibited | -2.16e+00 | 7.0e-02 | ATF3,BHLHE40,BTG2,CDKN1A,HMOX1,NECTIN4,STAT1,ZFP36 | NA |
| SOX9 | -5.00e-02 | transcription regulator | Inhibited | -2.16e+00 | 0.0e+00 | Acan,ADAMTS1,ADAMTS10,AR,C9,CD274,CDKN1A,COL2A1,CXCR4,CYP26B1,Elf5,FGFBP1,FOS,FOXC1,FZD9,GAS7,OSR2,SMPD3,SOSTDC1,SOX2,Sry,WNT11 | 530 (23) |
| SMAD7 | -2.00e-02 | transcription regulator | Inhibited | -2.17e+00 | 0.0e+00 | Acan,ADH1C,BMP2,BMP7,CCL2,Ccl2,CDKN1A,COL2A1,CRP,CXCL10,FSTL3,GADD45A,HMOX1,IL12B,ITGA7,MMP9,MYC,NFKBIA,PLAT,SERPINE1,SOX2,TGFA,TIMP1,TIMP3 | 429 (17) |
| IL27 | 1.20e-01 | cytokine | Inhibited | -2.17e+00 | 0.0e+00 | ADGRE1,CCL2,CCL4,CCR6,CD14,CD163,CD274,CD69,CEBPD,CIITA,CXCL10,FOS,GADD45G,GBP2,GZMB,HLA-DOB,IL12B,IL1A,LAG3,MX1,MYC,PTGS2,SOCS3,STAT1,TBX21,TNFSF10,TNFSF18 | 377 (17) |
| Relaxin | NA | group | Inhibited | -2.18e+00 | 0.0e+00 | AQP3,ARG2,EDN1,HAS1,HCN4,MMP8,MMP9,TIMP1 | 367 (15) |
| MAX | 5.10e-01 | transcription regulator | Inhibited | -2.18e+00 | 0.0e+00 | ACTC1,AR,CDKN1A,EDN1,EZH2,GADD45A,GADD45B,HK2,LRRN3,MYC,MYCT1,ODC1,TXNIP,XCL1 | NA |
| DSCAML1 | 3.20e-01 | other | Inhibited | -2.18e+00 | 0.0e+00 | BMP6,CNTNAP1,GADD45G,GPR3,JAK3,KCNA2,LGI1,MYC,NRN1,PAX5,PCDHB2,PDGFB,PLXNA4,PRKCB,PRKCH,SEMA7A,SNCAIP | NA |
| IL7R | NA | transmembrane receptor | Inhibited | -2.18e+00 | 0.0e+00 | ARHGAP10,BAIAP2,CD19,CD79A,EZH2,IRF4,MYC,PAX5,PKIA,SDCBP2,SELE,SELL,SLAMF6,SOCS2 | 313 (14) |
| CREBZF | 3.70e-01 | transcription regulator | Inhibited | -2.18e+00 | 0.0e+00 | ATF4,EDEM1,ERN1,FASN,PDK4 | NA |
| CDK1 | 3.60e-01 | kinase | Inhibited | -2.18e+00 | 1.0e-02 | AR,Ccl2,CDKN1A,CXCL10,TIMP1 | NA |
| TRIM21 | -3.00e-01 | enzyme | Inhibited | -2.19e+00 | 1.0e-02 | CXCL10,GCLC,HMOX1,IL12B,MYC | NA |
| SMARCC1 | -6.00e-02 | transcription regulator | Inhibited | -2.20e+00 | 0.0e+00 | CD79A,CD79B,CDKN1A,IRS1,KDR,LPIN1,PAX5,SOX2 | NA |
| HSPB1 | 0.00e+00 | other | Inhibited | -2.20e+00 | 1.0e-02 | Ccl2,CDKN1A,CXCL2,CXCL3,IL1A | NA |
| verteporfin | NA | chemical drug | Inhibited | -2.20e+00 | 4.0e-02 | CDKN1A,CXCL2,GADD45A,IL33,NFKBIA | NA |
| torin1 | NA | chemical reagent | Inhibited | -2.20e+00 | 1.0e+00 | ADH1C,ATF4,CD274,CLDN11,FASN,HK2,PDHA1,PTGS2 | NA |
| MTM1 | -3.80e-01 | phosphatase | Inhibited | -2.21e+00 | 1.0e-02 | CTSV,GABARAPL1,MAP1LC3B,NEDD4L,TRIM63 | 451 (16) |
| CYB5R4 | -2.00e-01 | enzyme | Inhibited | -2.21e+00 | 0.0e+00 | ATF3,FASN,GCLC,HMOX1,Mt1 | 290 (11) |
| CRBN | 7.00e-02 | enzyme | Inhibited | -2.22e+00 | 0.0e+00 | ERN1,IRF4,MYC,ODC1,PTGS2 | 477 (21) |
| STO-609 | NA | chemical - kinase inhibitor | Inhibited | -2.22e+00 | 0.0e+00 | CXCL2,CXCL3,F3,SELE,SELP | 251 (9) |
| paricalcitol | NA | chemical drug | Inhibited | -2.22e+00 | 1.0e-02 | BCL2L1,BMP2,Ccl2,F2RL1,F3,PTGS2,TIMP1 | 366 (19) |
| SL 327 | NA | chemical - protease inhibitor | Inhibited | -2.22e+00 | 2.0e-02 | CA12,FOS,KCNK1,NEDD4L,NOCT | NA |
| PARK7 | 0.00e+00 | enzyme | Inhibited | -2.22e+00 | 4.0e-02 | AR,Ccl2,IL12B,PTGS2,SOX2 | NA |
| TGS1 | -1.00e-02 | enzyme | Inhibited | -2.22e+00 | 6.0e-02 | ATF4,ERN1,RASGRF1,SESN1,SESN2 | NA |
| ARRB2 | 4.00e-02 | other | Inhibited | -2.23e+00 | 0.0e+00 | Ccl2,CXCL2,CXCL3,F3,GRK5,JUNB,MYC,PTGS2,SERPINE1,STAT1 | 349 (13) |
| let-7a-5p (and other miRNAs w/seed GAGGUAG) | NA | mature microRNA | Inhibited | -2.23e+00 | 1.9e-01 | ADAMTS15,AURKB,BCL2L1,CHRNA7,EDN1,HMOX1,IFRD1,MMP9,MYC,PDGFB,PTGS2,SNAP23,TGFBR3,THBS1 | NA |
| NELFB | -6.00e-02 | other | Inhibited | -2.24e+00 | 0.0e+00 | ATF3,CDKN1A,GADD45A,GADD45B,MKNK2 | 271 (10) |
| RNF20 | -9.00e-02 | enzyme | Inhibited | -2.24e+00 | 0.0e+00 | CDKN1A,FOS,FOSL2,KCNJ11,Meis1,MYC | NA |
| xanthohumol | NA | chemical drug | Inhibited | -2.24e+00 | 1.0e-02 | BCL2L1,FASN,FOS,GAB2,HMOX1,MYC | NA |
| TYROBP | -7.00e-02 | transmembrane receptor | Inhibited | -2.24e+00 | 5.0e-02 | CCL2,CD69,CD83,CD84,KLRD1,NPC2,Siglech | NA |
| PAX1 | NA | transcription regulator | Inhibited | -2.24e+00 | 1.0e-01 | COL2A1,Elf5,KRT17,KRT7,PPL | NA |
| ABCB4 | NA | transporter | Inhibited | -2.24e+00 | 0.0e+00 | BCL2L1,Ccl2,CXCL10,LGALS3,MMP9,NR5A2,SERPINE1,SLC10A1,SOCS3,TIMP1 | 390 (17) |
| POU5F1 | NA | transcription regulator | Inhibited | -2.27e+00 | 0.0e+00 | ADORA2A,ALB,APCDD1,ATP6V0A4,BCL2A1,BMP2,BMPER,CD27,CD274,CDKN1A,CIDEA,CTSV,CXCL10,CXCL3,DUSP1,Elf5,EPHA2,GADD45A,GADD45G,GBP4,HK2,INHBA,IRS1,KRT17,LOXL1,LTA,Meis1,MMP9,MYC,MYCN,NPC2,NRP1,Oasl2,PPARA,PPL,SLC11A1,SOCS3,SOX2,TET1,TGM1,TNFRSF14,TNFRSF19,TNFRSF21,TNFSF10,TNFSF8,TP53BP2,TP73,TXNRD1,USP18,WNT5A,ZEB2 | 479 (21) |
| IL12 (family) | NA | group | Inhibited | -2.29e+00 | 0.0e+00 | AQP3,ATF3,BCL2L1,CCL4,CCR6,CD274,CD40LG,CD69,CD8A,CHRNA7,DDIT4,FOSL2,GIMAP4,GZMB,IKZF3,IRF4,KLRD1,LIF,MYC,NFIL3,NRP1,ODC1,PRF1,PTPRC,SELL,SERPINB1,SOCS2,STAT1,TBX21,TNFRSF18,TNFSF10 | 528 (19) |
| BCL3 | 4.70e-01 | transcription regulator | Inhibited | -2.29e+00 | 0.0e+00 | CD274,CD69,CXCL10,CXCL2,CXCL3,FABP3,FOS,IL1A,NFKBIA,PDK4,PLAUR,S100A8 | 353 (14) |
| PELP1 | 3.30e-01 | other | Inhibited | -2.31e+00 | 0.0e+00 | BCL2L1,BMP2,CCNA1,CDKN1A,CKMT1A/CKMT1B,CTSH,CXXC5,DOCK11,FOS,G0S2,GJB2,HS3ST5,HSD17B2,IFI44,IKBKE,IL1A,KCNK2,KRT81,KYNU,MAP1LC3B,MLPH,MMP9,MYC,PSAT1,PTGS2,SESN2,TCN2 | 503 (21) |
| oleic acid | NA | chemical - endogenous mammalian | Inhibited | -2.33e+00 | 0.0e+00 | APOB,AQP3,ATF3,ATF4,Ccl2,CERS6,CPT1B,DUSP1,EDN1,FASN,FOS,GADD45A,GADD45B,GCLC,HK2,HMOX1,IAPP,LCN2,MAP1LC3B,Mt1,NFKBIA,PCK1,PDK4,PIK3IP1,PLIN5,PNPLA2,PNPLA3,PPARA,PTGS2,SELE,SERPINE1,SOAT1,SPHK1,TXNIP | 574 (25) |
| miR-16-5p (and other miRNAs w/seed AGCAGCA) | NA | mature microRNA | Inhibited | -2.33e+00 | 5.0e-01 | ANAPC16,CA12,CHORDC1,HMOX1,HYAL3,IFRD1,NPR3,OGT,PSAT1,PTGS2,SLC16A3,SLC7A1 | NA |
| ZBTB10 | -1.00e-02 | transcription regulator | Inhibited | -2.35e+00 | 0.0e+00 | ARID5A,CCL24,CCL4,CD274,CD83,CD8A,CXCL10,CXCL3,GBP4,GBP5,IFIT1,IFITM2,Igtp,IL12B,IL4R,IRF4,Irgm1,ISG15,Klre1,Klrk1,LTA,Mx2,PTGS2,SEMA7A,SERPINE1,TNFRSF14,TNFRSF8,ZBP1 | 272 (11) |
| miR-3648 (miRNAs w/seed GCCGCGG) | NA | mature microRNA | Inhibited | -2.36e+00 | 1.4e-01 | EVA1C,FBRSL1,FRAT2,JUNB,KIF21B,MAP1LC3B,MYC,NRTN,ZBED3 | NA |
| losartan potassium | NA | chemical drug | Inhibited | -2.38e+00 | 0.0e+00 | AQP1,ATF4,ATP1A1,BMP7,Ccl2,CIDEA,CREM,CXCL10,CXCL3,EDN1,EDNRA,F3,FOS,GBP2,GRK5,KLF15,MMP8,MMP9,PTGS2,RBP4,Retnlg,S100A8,SERPINE1,SOCS3,TBX21,TIMP1,TMEM26 | 444 (19) |
| FOXC1 | -6.00e-01 | transcription regulator | Inhibited | -2.39e+00 | 0.0e+00 | COL2A1,CXCR4,DLL1,FOS,GBP4,IFIT1,ISG15,KRT75,MMP9,MX1,OAS2,OSR2,SERPINE1,SFN,SOCS3,STAT1,SYT6,TGM1,TRIM14,USP18,WDR72,WNT5A,ZSCAN18 | 232 (8) |
| HES1 | 3.00e-02 | transcription regulator | Inhibited | -2.39e+00 | 5.0e-02 | ADAMTS5,CDKN1A,DLK1,DLL1,DUSP1,GLI1,PAX5 | NA |
| POU2AF1 | -1.15e+00 | transcription regulator | Inhibited | -2.40e+00 | 0.0e+00 | BCL2L1,BTLA,CD69,CD79A,CD79B,CD83,CXCR4,EZH2,GADD45G,IFI44,IFI44L,IL4R,IRF4,LCK,MX1,MYC,PAX5,POU2AF1,TBX21,TNFRSF13C | 487 (19) |
| LY294002 | NA | chemical drug | Inhibited | -2.41e+00 | 0.0e+00 | ABCB1,ADAMTS1,ADH1C,AQP3,AR,ATF3,ATF4,BCL2L1,BHLHE40,BMP2,CCL2,Ccl2,CD14,CD274,CD40LG,CD69,CD83,CDKN1A,CLDN4,CPA2,CREM,CRP,CUBN,CXCL10,CXCL2,CXCL3,CXCL6,DNASE1L3,DUSP1,EGR3,ERBB3,EREG,F3,FASN,FOS,FOSL1,FOXC1,GCLC,GEM,HK2,HMOX1,IER3,IL12B,IL1A,IL1R2,IL33,IRS1,ITGA2B,JUNB,LCN2,LIF,LMO4,LOXL1,MAP3K8,MMP9,MYC,NFKBIA,NRN1,NTRK3,PTGS2,PTX3,RAMP3,RND3,SELP,SERPINE1,SFN,SLC38A3,SNX19,SOCS2,SOCS3,SPN,ST8SIA1,TFPI2,THBS1,TNFSF8,WNT5A,WNT7A,ZBTB16,ZFP36,ZNF184 | 508 (17) |
| WTAP | -9.00e-02 | other | Inhibited | -2.41e+00 | 0.0e+00 | Ccl2,CD14,CXCL10,CXCL3,CXCL6,PNPLA2 | 128 (3) |
| canrenoate potassium | NA | chemical drug | Inhibited | -2.42e+00 | 0.0e+00 | Ccl2,CDKN1A,Eda,EDN1,LGALS3,PTGS2 | 238 (7) |
| CDK19 | 6.00e-02 | kinase | Inhibited | -2.43e+00 | 0.0e+00 | ATF3,BAIAP2,BTG2,CDKN1A,CXCL2,DDIT4,EPHA2,GADD45A,HMOX1,HSPA4L,IL1A,LIF,MYC,OSGIN1,Podxl,PROCR,SAT1,SESN1,SFN,SPHK1,TCN2,TGFA,TXNIP,UPP1 | 254 (7) |
| obeticholic acid | NA | chemical drug | Inhibited | -2.43e+00 | 0.0e+00 | ABCB1,ABCB11,ABCC2,Ccl2,CXCL2,CXCL3,NR0B2,PCK1,PTGS2,SLC10A1,TIMP1 | 471 (16) |
| Cyp2c70 | -4.60e-01 | enzyme | Inhibited | -2.43e+00 | 0.0e+00 | ABCB1,Ccl2,CXCL10,CXCL2,CXCL3,TIMP1 | NA |
| PARP9 | -2.80e-01 | enzyme | Inhibited | -2.43e+00 | 0.0e+00 | HLA-DOB,IFI44,IFIT1,ISG15,OAS2,STAT1 | 231 (14) |
| POLR2M | 3.70e-01 | other | Inhibited | -2.43e+00 | 0.0e+00 | BTG2,CDKN1A,DDIT4,ENC1,EPHA2,SESN2 | NA |
| miR-30c-5p (and other miRNAs w/seed GUAAACA) | NA | mature microRNA | Inhibited | -2.44e+00 | 1.1e-01 | ADAMTS15,GNAI2,HEYL,IFRD1,KRT7,MYC,NPR3,P4HA2,PDGFB,PPP3R1,SLC38A2,SLC7A1,WNT5A | NA |
| HNF1A | -3.40e-01 | transcription regulator | Inhibited | -2.44e+00 | 0.0e+00 | ABCC2,ADH1C,ALB,ANGPTL3,APCS,APOB,AQP3,BCL2L1,BMP3,C9,CBS/LOC102724560,CCL28,CDO1,COQ10B,CPB2,CRP,FGA,FGL1,G0S2,GAL,GJB1,GLUL,GRTP1,HNF4A,HPX,HSD17B2,IAPP,ITIH4,MAPK15,MRO,NR0B2,NR5A2,PAX5,PCK1,PLA1A,PLG,RAB37,SERPINE1,SLC10A1,SLC26A1,SLC5A1,Slco1a1,SOCS3,SSTR4,TMPRSS4,TRPM2,UGT2B10,ZBED3 | 534 (24) |
| PXDN | -2.00e-01 | enzyme | Inhibited | -2.45e+00 | 0.0e+00 | CDKN1A,DDIT4,DUSP1,LOX,MYC,NFIL3 | NA |
| SOX7 | -6.70e-01 | transcription regulator | Inhibited | -2.45e+00 | 1.6e-01 | CALCRL,Elf5,KDR,KRT17,KRT7,PPL | NA |
| diphenyleneiodonium | NA | chemical reagent | Inhibited | -2.46e+00 | 0.0e+00 | ATF3,BMP2,CCL2,Ccl2,CLDN4,CXCL2,CXCL3,F3,FOS,GCLC,HMOX1,MMP9,PTGS2,SELE,SELL,SERPINE1,TIMP1 | 450 (17) |
| pyridostatin | NA | chemical reagent | Inhibited | -2.49e+00 | 0.0e+00 | CMPK2,CXCL10,GBP4,IFI44,IFI44L,IFIT1,IFITM2,ISG15,MX1,RSAD2,SELL,TRIM14,UBA7,USP18 | 338 (14) |
| Ifnar | NA | group | Inhibited | -2.54e+00 | 0.0e+00 | CCL2,Ccl2,CD274,CD8A,CXCL10,GBP2,IL12B,Irgm1,ISG15,MMP9,Mx2,OAS2,RNF213,RSAD2,STAT1,TNFSF10,USP18,ZBP1 | 349 (15) |
| JAK inhibitor I | NA | chemical drug | Inhibited | -2.55e+00 | 0.0e+00 | BCL2L1,CXCL10,CXCL2,CXCL3,CXCL6,MMP9,PTGS2,SOCS3,TIMP1,TRPA1 | 386 (18) |
| IFNA2 | NA | cytokine | Inhibited | -2.59e+00 | 0.0e+00 | ADGRE1,CCL2,CD274,CD28,CD69,CDKN1A,CIITA,CMPK2,CXCL10,GBP2,GBP4,GEM,HSH2D,IFI44,IFI44L,IFIT1,IFITM2,IL2RB,ISG15,KCNJ6,MMP9,MX1,Mx2,MYC,OAS2,PLAT,RASSF1,RSAD2,SOCS2,SOCS3,STAT1,TBX21,TNFSF10,TRIM14,UBA7,USP18,ZBP1 | 369 (15) |
| IFNL3 | NA | cytokine | Inhibited | -2.59e+00 | 0.0e+00 | IL12B,MMP9,MX1,Mx2,RSAD2,STAT1,USP18 | 453 (18) |
| CpG ODN 2216 | NA | chemical reagent | Inhibited | -2.62e+00 | 0.0e+00 | CD14,CD69,CD83,IL12B,STAT1,TNFSF10,TNFSF18 | 246 (15) |
| ribavirin | NA | chemical drug | Inhibited | -2.63e+00 | 1.0e-02 | CCL17,IFI44L,ISG15,MX1,RSAD2,STAT1,USP18 | 477 (19) |
| CAT | -2.60e-01 | enzyme | Inhibited | -2.64e+00 | 0.0e+00 | BCL2A1,CCL2,Ccl2,CD69,CDKN1A,CLCA1,GCLC,HMOX1,MMP9,PTGS2,SERPINE1,THBS1,TIMP1 | 492 (22) |
| IFNL1 | NA | cytokine | Inhibited | -2.64e+00 | 0.0e+00 | ATF3,CD83,CMPK2,CXCL10,GBP5,IFI44,IFI44L,IFIT1,IFITM2,IL12B,ISG15,MX1,OAS2,RSAD2,STAT1,TRIM14,USP18 | 487 (17) |
| U0126 | NA | chemical drug | Inhibited | -2.67e+00 | 0.0e+00 | ABCB1,ABCB11,Acan,ADAMTS4,ADGRE1,ADORA2B,AQP1,AQP3,ARG2,ATF3,ATF4,BCL2L1,BHLHE40,BMP6,CCL17,CCL2,Ccl2,CCL4,CCNO,CD274,CD40LG,CD69,CDKN1A,CEBPD,CIITA,CLDN4,COL2A1,CRY2,CXCL10,CXCL2,CXCL3,CXCR4,DBNDD1,DNASE1L3,DUSP1,EDN1,EGR3,ELL,EPHA2,EREG,ERRFI1,F3,FASN,FKBP5,FMO3,FOS,FOSL1,G0S2,GADD45B,GALNT3,GCLC,GFI1,GFPT2,GLI1,HMOX1,IER3,IL12B,IL1A,IL1R2,IL24,INHBA,ITGA2B,ITPKC,JUNB,KDR,LIF,MMP9,MUC5B,MYC,NRN1,OSMR,PER1,PLAUR,PRKCB,PRSS22,PTGS2,RND3,SCN1B,SELP,SERPINE1,SHB,SIX4,SOCS3,SOX2,SPNS2,STAT1,TFPI2,TGFA,THBS1,TIMP3,TRIB1,UBC,ZFP36 | 513 (15) |
| IFNB1 | NA | cytokine | Inhibited | -2.69e+00 | 0.0e+00 | BCL2L1,BHLHE40,CCL2,Ccl2,CCL4,CD14,CD274,CD83,CDKN1A,CMPK2,CREM,CXCL10,CXCL2,CXCL3,CXCL6,DLL1,FOS,GBP2,GBP4,GBP5,GBP7,GLP2R,IFIT1,Igtp,IL12B,IL1A,IL24,Irgm1,ISG15,MMP9,MX1,MYC,NOCT,OAS2,Oasl2,PDK4,PTGS2,RASSF1,RND3,RSAD2,SIDT1,STAT1,THBS1,TIMP1,TNFSF10,TRIM14,UBA7,USP18,ZBP1 | 297 (16) |
| SFTPA1 | 4.80e-01 | transporter | Inhibited | -2.71e+00 | 0.0e+00 | Ccl2,CXCL10,CXCL2,CXCL3,ERN1,EVI2B,FOS,GABRP,GFPT2,IL1A,KCNMB4,LOX,MYC,PDK4,SERPINE1,TCEA3 | 392 (16) |
| IFNA1/IFNA13 | NA | cytokine | Inhibited | -2.71e+00 | 0.0e+00 | AR,CD274,CD69,CD83,CXCL10,GEM,IFIT1,ISG15,MX1,MYC,OAS2,PTGS2,RSAD2,STAT1,ZBP1 | 292 (17) |
| SU6656 | NA | chemical toxicant | Inhibited | -2.74e+00 | 0.0e+00 | ATF3,Ccl2,GFPT2,IER3,INHBA,JUNB,Mt1,MYC,NFIL3,PTGS2,SOCS3 | 429 (18) |
| PML | -5.60e-01 | transcription regulator | Inhibited | -2.74e+00 | 0.0e+00 | ACSM1,CCNA1,CDKN1A,CIITA,CPT1A,CPT1B,CXCR4,FASN,FTL,GADD45A,HMOX1,IFI44,IFI44L,IFIT1,IL1A,ISG15,MAFF,MX1,OAS2,PDK4,PRKCH,STAT1,TXNRD1 | 497 (18) |
| IFNA4 | NA | cytokine | Inhibited | -2.79e+00 | 0.0e+00 | ATP2B4,CD274,CD69,CXCL10,GBP2,GBP5,H2-T22,H2-T24,IFIT1,Irgm1,ISG15,MAP3K8,MX1,Mx2,MYC,RSAD2,TREML2,USP18,ZBP1 | 412 (18) |
| COLQ | -5.00e-01 | other | Inhibited | -2.80e+00 | 1.0e-02 | ADAMTS5,COL2A1,FRAS1,ITGA7,MMP16,MMP9,PRIMA1,SDC4,TIMP1 | NA |
| CpG ODN 2006 | NA | chemical reagent | Inhibited | -2.81e+00 | 0.0e+00 | BCL2A1,BCL2L1,CCL2,CD22,CD27,CD274,CXCL10,DLL1,FCER2,FCN1,FOS,GBP4,GBP5,GZMB,IFI44,IFI44L,IFIT1,IL12B,IL2RB,LAT2,LAX1,LGALS3,MS4A1,MX1,PAX5,PRKCB,RGCC,RSAD2,SELL,SFPQ,STAT1,TLR10,TLR5,TNFAIP6,TNFRSF13C,TNFSF10,TNFSF18,USP18,ZC3H12A | 282 (15) |
| IL20 | -7.00e-02 | cytokine | Inhibited | -2.83e+00 | 0.0e+00 | ALB,CCL2,CRP,FGL1,MMP9,PLG,RBP4,SERPINC1 | 307 (15) |
| Immunoglobulin | NA | complex | Inhibited | -2.85e+00 | 0.0e+00 | ADAMTS5,ADGRE1,ADRA1A,ATP6V1E2,BCL2A1,BCL2L1,BMP2,BMP7,C3AR1,CBS/LOC102724560,CCL17,CCL19,CCL2,Ccl2,CCL4,CCR6,CD14,CD163,CD274,CD28,CD40LG,CD69,CD83,CD8A,CEBPD,CIDEA,CIITA,CLCA1,CMPK2,CPT1A,CRISPLD2,Csprs (includes others),CTHRC1,CTSH,CX3CR1,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,CYSLTR1,DDIT4,DUSP1,DYSF,EGR3,ENO3,EZH2,F3,FAM107A,FASN,FKBP5,FOS,GAS7,GBP5,GFI1,GLI1,GLUL,GNRH1,GZMA,GZMB,GZMM,H2-T24,HK2,HMOX1,HSD11B2,HSH2D,IER3,IFIT1,IL12B,IL1A,IL1R2,IL24,IL2RB,IL33,IL4R,INHBA,IPMK,IRF4,ISG15,KDR,KLRD1,LAG3,LCK,LCN2,LGALS3,LILRB3,LOX,LRRC32,LTA,MAFF,MAP1LC3B,MERTK,MMP9,MOXD1,MX1,Mx2,MYC,NFIL3,NFKBIA,NRP1,OAS2,OSBPL3,PAX5,PCK1,PDHA1,PDK4,PHKG1,PIK3IP1,PNPLA2,POU2F2,PPARA,PRF1,PTGS2,PTPRC,PTX3,RCN1,RGS16,RSAD2,S100A8,SAT1,SELE,SELL,SELP,SERPINB1,SLC11A1,SLC43A3,SLC6A6,SLC7A5,SOAT1,SOCS3,SOX2,SPHK1,STAT1,TBX21,TGFBR3,TIMP1,TNFRSF18,TNFRSF8,TNFSF10,TNFSF8,TRAF3IP3,TRPV1,TXNIP,TXNRD1,USP18,XCL1,ZBTB16,ZEB2 | 469 (16) |
| PAX5 | -1.03e+00 | transcription regulator | Inhibited | -2.89e+00 | 0.0e+00 | BCL2L1,BLK,CD19,CD22,CD79A,CD79B,CIITA,CR2,FCER2,GRHL1,HK2,MYC,PAX5,POU2AF1,TNFRSF13C,TXNIP | NA |
| pembrolizumab | NA | biologic drug | Inhibited | -2.89e+00 | 0.0e+00 | CCL4,CD27,CD274,CD83,CD8A,GZMA,GZMB,IFIT1,LAG3,PRF1,PTGS2,STAT1 | 182 (7) |
| actinomycin D | NA | biologic drug | Inhibited | -2.90e+00 | 0.0e+00 | ABCC2,ALB,AR,ATF4,ATP1A1,BCL2A1,CCL2,CD27,CD28,CDKN1A,CERS6,COL2A1,DDIT4,DUSP1,ERRFI1,F3,FASN,FOS,FOSL2,GADD45A,HMOX1,IL1R2,IRS1,LTA,MAOA,Mt1,MYC,PFKFB3,PLAUR,PTGS2,PTX3,SELE,SERPINE1,SOCS3,SPHK1,TGFA,THRB,TP53BP2 | 599 (22) |
| IRF9 | 4.00e-02 | transcription regulator | Inhibited | -2.91e+00 | 0.0e+00 | CCL19,CD274,CD69,CIITA,CMPK2,CXCL10,F830016B08Rik,GBP7,HDC,IFIT1,IL1A,ISG15,MX1,OAS2,Oasl2,RSAD2,SOCS3,STAT1,TNFSF10,USP18,ZBP1 | 450 (19) |
| valsartan | NA | chemical drug | Inhibited | -2.93e+00 | 1.0e-02 | AQP1,Ccl2,CD163,EDN1,F3,FOS,PTGS2,SERPINE1,TIMP1 | 415 (19) |
| NONO | -1.00e-02 | transcription regulator | Inhibited | -2.96e+00 | 0.0e+00 | CMPK2,CXCL10,EREG,FASN,GBP4,GBP5,HSH2D,IFI44,IFI44L,IFIT1,IFITM2,IKBKE,ISG15,MX1,NUPR1,OAS2,PDE10A,PDE4A,PDE4C,RNF213,RSAD2,STAT1,TNFSF10,TNFSF18,TNFSF8,USP18 | 240 (7) |
| CD3 | NA | complex | Inhibited | -2.99e+00 | 0.0e+00 | AQP3,ATF4,BCL2A1,BCL2L1,CCL17,CCL4,CCR6,CCR9,CD27,CD274,CD28,CD40LG,CD69,CD83,CD8A,CREM,CTSW,CXCL10,CXCR4,DPYSL5,EGR3,ELK3,FMO3,FOS,FTL,GFI1,GLI1,GPR37,GZMA,GZMB,HMCN1,HPX,ICAM5,ID4,IFIT1,IL12B,IL1A,IL21R,IL2RB,IL4R,IRF4,ITGB7,JAK3,JUNB,KCNA5,LCK,LTA,MAP3K8,MYC,NFKBIA,NFX1,ODC1,PDE4A,PRF1,PTGS2,PTPRC,RBM3,SLC7A1,SMO,SOCS2,SOCS3,STAT1,STEAP2,TBX21,TFPI2,THBS1,TNFRSF18,TNFRSF8,TNFSF10,TNFSF18,TP73,TRA2A,TXNRD1,VIPR2,XCL1,ZFP36 | 420 (19) |
| FLT3LG | -4.80e-01 | cytokine | Inhibited | -3.05e+00 | 0.0e+00 | ADGRE5,CCR9,CD19,CD274,CD3G,CD79A,CD83,CXCL2,CXCL3,CXCR4,IL2RB,MAP1LC3B,PAX5,PTPRC,SPN,TNFRSF18 | 454 (19) |
| SNCA | -7.00e-02 | enzyme | Inhibited | -3.13e+00 | 0.0e+00 | ADGRE5,ADRA1A,ARHGEF28,BAIAP2,BCL11B,BCL2L1,BHLHE40,CA12,CCL2,Ccl2,CD22,CDH15,CDH6,CDHR1,CIITA,CRYM,CTHRC1,CTSW,CXCR4,DLK1,DOC2B,DUSP1,ELL,FAM107A,FAM81A,GADD45A,GBP2,GBP5,GCLC,GRIN2D,ICAM5,Ifgga2l1/RGD1309362,IFRD1,IL1A,ISG15,JPH2,KCNF1,KCNG1,KCNJ11,KCNN3,MAP1LC3B,MMP8,MMP9,MX1,Mx2,Nrgn,PCDHA4,PLAUR,PRF1,PRKCG,PTGS2,RBP4,RPRML,RSAD2,SERPINB1,SERPINE1,SFN,SGMS1,SPAG8,TNFRSF19,WIPF3 | 437 (18) |
| SPI1 | -3.00e-01 | transcription regulator | Inhibited | -3.13e+00 | 0.0e+00 | ADGRE1,BCL11A,C3AR1,CCL17,CCL4,CCR6,CD14,CD180,CD19,CD40LG,CD79A,CD79B,CDKN1A,CIITA,CMPK2,CSF3R,CXCL10,FOS,GFI1,IFI44,IFI44L,IFIT1,IL12B,IL1R2,IL24,IL33,IRF4,ISG15,LILRB3,LTB,MS4A1,MX1,MYC,P2RY10,PTGS2,PTPRC,RSAD2,TNFRSF14,TNFSF10,USP18 | 405 (17) |
| PD98059 | NA | chemical - kinase inhibitor | Inhibited | -3.13e+00 | 0.0e+00 | ABCC2,ANKRD1,AR,ATF3,ATF4,BCL2L1,BMP2,CCL19,CCL2,Ccl2,CCL4,CD14,CD37,CD69,CD83,CDKN1A,CEBPD,CHRNA7,CREB1,CREM,CRP,CTSH,CXCL10,CXCL2,CXCL3,CXCR4,DIO2,DUSP1,ECE1,EDN1,EGR3,EREG,ERRFI1,F3,FASN,FGFBP1,FKBP5,FOS,FOSL1,GADD45A,GAS7,GNRH1,HAS1,HMOX1,HPCAL1,HSD11B2,IER3,IL12B,IL1A,IL24,ITGA2B,JUNB,KLF15,LAMA5,MMD,MMP9,MUC5B,MYC,MYCN,MYOCD,NFKBIA,ODC1,OSMR,PCK1,PDGFB,PER1,PLA1A,PLAT,PLAUR,PTGS2,PTX3,RAB20,S100A8,SEC14L2,SELE,SELENBP1,SELL,SERPINE1,SLC38A2,SLC6A2,SOAT1,SOCS2,SOCS3,SOX2,THBS1,TIMP1,TNFAIP6,TP73,TXNIP | 500 (17) |
| RXRA | 4.00e-02 | ligand-dependent nuclear receptor | Inhibited | -3.18e+00 | 0.0e+00 | ABCB1,ABCB11,ABCC2,Acot1,ADH1C,ANGPTL3,ARG2,ATF4,BAAT,CAMK1D,CCL17,CCR9,CD200R1L,CDKN1A,CDO1,CEBPD,CIDEA,CPT1A,CPT1B,CTSH,CXCL10,CXCL2,DLK1,EHD3,FABP3,FASN,FLRT3,FOS,FTL,GADD45G,GCLC,GFI1,GHRHR,HMOX1,HNF4A,HSD11B2,HSF2BP,IER3,IL12B,IL1A,LCN2,MAOB,MGP,MUC13,MYCN,NEDD9,NR0B2,NR5A2,NUPR1,OSMR,PCK1,PDGFB,PLCL1,PPARA,PURG,RGN,S100A8,SAT1,SELP,SFTPB,SLC10A1,TNFSF10,Tnfsf9,TRH,ZC3H12A | 577 (23) |
| SP600125 | NA | chemical drug | Inhibited | -3.19e+00 | 0.0e+00 | ABCB1,ABCB11,ADAMTS4,ADAMTS9,AQP1,ATF3,BBOX1,BCL2L1,BTG2,CA4,CCL2,Ccl2,CCL4,CD83,CDKN1A,CLDN4,CPT1B,CRYM,CTHRC1,CXCL10,CXCL2,CXCL3,CXCL6,CXCR4,DDIT4,DUSP1,F3,FASN,FLRT3,FOS,GADD45A,GBP2,HAS1,HMOX1,HNF4A,IL12B,IL1A,IL6R,INHBA,IRS1,ISG15,JUNB,LAMA5,MAP1LC3B,MMP9,MUC5B,NEDD9,NFKBIA,NR0B2,NUPR1,OSBPL6,P4HA2,PDGFD,PER1,PTGS2,PTX3,SELE,SELP,SERPINE1,SERPINH1,SOCS3,SOX2,SOX7,SPHK1,THBS1,TNFRSF18,TRIM63,TTC30B,ZFP36 | 472 (15) |
| IRF1 | -1.70e-01 | transcription regulator | Inhibited | -3.20e+00 | 0.0e+00 | CCL19,CCL2,CD274,CDKN1A,CIITA,CMPK2,CXCL10,CXCL2,CXCL3,DNASE1L3,F3,GBP2,GBP4,IFI44,IFI44L,IFIT1,IL12B,IL33,IRF4,ISG15,LTB,MMP9,MX1,MYC,OAS2,ODC1,PTGS2,RSAD2,SELL,STAT1,TNFSF10 | 355 (17) |
| VCAN | -5.30e-01 | other | Inhibited | -3.20e+00 | 0.0e+00 | ADAMTS9,ANXA8/ANXA8L1,CCL2,Ccl2,CCL4,CDKN1A,CIDEA,CRISPLD2,CXCL2,CXCL3,CXCL6,F3,HAS3,HYAL2,IFI44,IFI44L,IFIT1,IL12B,LCN2,LGALS3,MMP9,MX1,NFKBIA,OAS2,STAT1,TGFA,TIMP1 | 418 (17) |
| SENP3 | 2.70e-01 | peptidase | Inhibited | -3.21e+00 | 0.0e+00 | CCL4,CCR9,CD8A,CXCL10,H2-T22,H2-T24,IFI44,IL12B,ISG15,OAS2,Oasl2,RSAD2,STAT1,TNFSF10 | 416 (17) |
| Srgn | 7.00e-02 | other | Inhibited | -3.21e+00 | 0.0e+00 | ADGRE1,BANP,CD83,CD8A,EGR3,FCMR,IL12B,IL21R,Irgm1,LCK,MMP9,POU2AF1,SBK1,THBS1 | 212 (7) |
| IRF3 | 9.00e-02 | transcription regulator | Inhibited | -3.28e+00 | 0.0e+00 | ABCC2,ARG2,BTLA,CCL19,CCL2,Ccl2,CCL4,CD274,CD69,CMPK2,CXCL10,GBP5,IFI44,IFI44L,IFIT1,Igtp,IL12B,IL1A,IL33,Irgm1,ISG15,JUNB,Klrk1,LAG3,LCN2,MMP9,Mx2,OAS2,Oasl2,Pmaip1,RSAD2,STAT1,TIMP3,TNFSF10,USP18,ZBP1 | 218 (14) |
| CHROMR | NA | other | Inhibited | -3.29e+00 | 0.0e+00 | ARG2,CCL2,CD163,CDKN1A,CEBPD,CXCL10,DDIT4,GBP2,GBP4,GBP5,GEM,IFI44,IFI44L,IFIT1,ISG15,JUNB,MAFF,MX1,OAS2,ODC1,PFKFB3,RSAD2,S100A8,SERPINE1,SPSB1,SSBP3,STAT1,TIMP1,TNFAIP6,TNFSF10,TRIM14,UBA7,USP18 | NA |
| TSC2 | -1.10e-01 | other | Inhibited | -3.32e+00 | 0.0e+00 | ATF3,ATF4,Ccl2,CDKN1A,CXCL10,FAM107A,FASN,FOS,HK2,HMOX1,IFI44,IL22RA1,IRS1,LGALS3,LPAR1,MAOB,MGP,Mt1,NPC2,NTRK3,PDK4,PGM2L1,SOCS3,STAT1,ZFP36 | 478 (21) |
| ACOX1 | 1.00e-01 | enzyme | Inhibited | -3.33e+00 | 0.0e+00 | ACER2,ADAMTS1,APCS,BAAT,C9,CDKN1A,CTSV,Cyp3a25 (includes others),Cyp4a14,CYP7B1,DIO1,FASN,GADD45A,LCN2,LGALS3,NUPR1,PDK4,PEX11A,PIPOX,RBM3,RGN,SELENBP1 | 449 (13) |
| IRF7 | -2.70e-01 | transcription regulator | Inhibited | -3.34e+00 | 0.0e+00 | ATF4,BCL2L1,CCL19,Ccl2,CCNA1,CD69,CMPK2,CXCL10,GBP4,GBP5,IFI44,IFI44L,IFIT1,IFITM2,Igtp,IL1A,IL33,Irgm1,ISG15,MAP3K8,MX1,Mx2,OAS2,Oasl2,RSAD2,S100A8,STAT1,TNFSF10,UBA7,USP18,ZBP1 | 327 (19) |
| NC410 | NA | biologic drug | Inhibited | -3.41e+00 | 0.0e+00 | ATF3,BTG2,CCL17,CCL24,CD274,CDKN1A,CLEC10A,CMPK2,CXCL10,CXCL2,CXCL3,DUSP1,FOS,GADD45B,GBP5,HK2,IER3,IFIT1,IL1R2,JUNB,LYVE1,MMP9,Mt1,PRF1,RSAD2,STAT1 | NA |
| MSB0011359C | NA | biologic drug | Inhibited | -3.44e+00 | 0.0e+00 | ATF3,BTG2,CDKN1A,CLEC10A,CMPK2,CXCL10,CXCL3,DUSP1,FOS,GADD45B,GBP5,HK2,IER3,IFIT1,JUNB,LYVE1,Mt1,PRF1,RSAD2 | NA |
| PPARGC1A | -1.80e-01 | transcription regulator | Inhibited | -3.62e+00 | 0.0e+00 | ABCB11,ADAMTS1,ADAMTS5,AK1,ATP2B3,BMPER,Ccl2,CDKN1A,CEBPD,CIDEA,COL2A1,CPT1A,CPT1B,CXCL10,DIO1,DIO2,EDN1,FABP3,FANCG,FASN,FIBIN,FNDC5,FOS,GADD45B,HK2,HMOX1,IL1A,IL1R2,IL4R,INHBA,IRS1,KCNK1,LIF,LPIN1,MAOB,MAP2K6,MYC,NFKBIA,NR5A2,ODC1,OSMR,PCK1,PDHA1,PDK4,PLIN5,PNPLA2,PPARA,PPARGC1B,PTGS2,RBP4,SERPINH1,SESN2,Sik1,SLC24A2,SOCS3,SOX2,ST8SIA1,STAT1,TGFBR3,TIMP1,TIMP3,TNFRSF12A,TNFSF10,TRIM63,XDH | 556 (24) |
| ZMPSTE24 | -1.30e-01 | peptidase | Inhibited | -3.68e+00 | 0.0e+00 | ATF3,BTG2,CDKN1A,CTSV,CXCL2,CXCL3,DDIT4,DIO1,FGFR4,FGL1,GADD45A,GADD45B,GADD45G,RGS16,SESN1,SOCS2,SOCS3 | 489 (18) |
| SB-431542 | NA | chemical reagent | Inhibited | -3.73e+00 | 0.0e+00 | ADAMTS5,BMP6,CCL17,Ccl2,CD14,CD69,FASN,FOS,GADD45B,GAL,GJB2,IL1R2,LOX,MYC,PTX3,SERPINE1,SPSB1,TIMP1,TNFAIP6,TNFRSF12A,TNFSF10 | 620 (20) |
| IL21 | NA | cytokine | Inhibited | -4.05e+00 | 0.0e+00 | ARG2,BCL2L1,CCL17,CCL24,CCL4,CCR10,CD27,CD28,CD40LG,CD69,CDKN1A,CMPK2,CXCL10,GBP5,GZMA,GZMB,HSH2D,IFIT1,Igtp,IL21R,IL2RB,IRF4,Irgm1,ISG15,KLRD1,Klrk1,MMP9,Mx2,OAS2,PAX5,PRF1,PTPRC,RSAD2,SELL,SOCS2,SOCS3,TBX21,USP18 | 408 (15) |
| GNA14 | -4.60e-01 | enzyme | NA | NA | 0.0e+00 | ABCB1,ADAMTS1,ANKRD1,ANXA3,ATF3,BMP2,BTG2,Clec2d (includes others),CREM,CXCL3,GADD45A,GBP2,GRB14,HK2,KCNK2,KLHL41,LIF,MAP3K8,MEOX2,NFIL3,NPR3,PLAT,PLAUR,PTGS2,SELENBP1,SPHK1,STAT1,TNFAIP6,XDH | 342 (15) |
| GNA15 | -2.90e-01 | enzyme | NA | NA | 0.0e+00 | BMP3,Ccl2,CD69,CDO1,CEBPD,CXCL2,CXCL3,FOSL1,GADD45A,GBP2,GLUL,Gsta1,HMOX1,KLHL41,LGALS3,Mt1,MYC,NEXN,NPR3,ODC1,PLAT,PRSS35,PTGS2,RAPGEF4,SELENBP1,SLC6A6,SLC7A1,SNURF,TIMP1,XCL1,XDH | 433 (16) |
| IFNLR1 | 1.80e-01 | transmembrane receptor | NA | NA | 0.0e+00 | ATF3,CCL4,CMPK2,CXCL10,CXCL2,CXCL3,CXCL6,IAPP,IFI44,IL1A,ISG15,LIF,MX1,MYC,PTGS2,RSAD2,THBS1 | 329 (16) |
| MAFA | 2.10e-01 | transcription regulator | NA | NA | 0.0e+00 | ANKRD1,BCL2A1,Ccl2,CCL24,CDKN1A,CHRNA7,CXCL2,CXCL3,CXCL6,CXCR4,CYSLTR1,DLK1,ERBB3,FIGN,IL12B,IL1A,IL2RB,KCNJ11,LGALS3,LGI3,NGFR,PLCD1,Pln,PTGER3,RBP4,RYR2,SERPINE1,TNFRSF19,XCR1,ZNF189 | 88 (3) |
| RNA polymerase II | NA | complex | NA | NA | 0.0e+00 | ACTC1,ARID5A,CA12,CAP2,CD14,CD83,CDKN1A,CDO1,CIITA,CXCL2,CXCR4,DDX11,DIO1,DUSP1,FOS,FOSL1,FOSL2,FOXC1,GADD45A,GADD45B,GBP2,GBP7,HNF4A,HSD11B2,IL12B,JUNB,KCNF1,Meis1,MMP9,Mt1,MYC,MYCN,NFKBIA,NR5A2,OSGIN1,PCK1,PPARGC1B,PTGS2,RND3,SFN,SLC6A2,SOCS3,UBC | 456 (18) |
| RBCK1 | -9.00e-02 | transcription regulator | NA | NA | 0.0e+00 | ATP1A1,CCL2,CXCL10,CXCL3,CXCR4,GBP4,GBP5,IL1A,IL33,MAP2K6,MAP3K8,MYC,NFKBIA | 488 (14) |
| RGS10 | 1.50e-01 | enzyme | NA | NA | 0.0e+00 | CCL19,CCL2,CCR3,CCR6,CCR9,CD40LG,CRP,CXCL10,CXCL2,CXCL6,IL1A,IL1R2,IL2RB,LTA,SELP,XCR1 | 501 (16) |
| NKX3-1 | NA | transcription regulator | NA | NA | 0.0e+00 | AR,BTG2,CA12,CTSV,CX3CR1,FKBP5,FOS,MMP9,MYC,PRKCB,PTPRC,SDC4,SOAT1 | 437 (20) |
| mezerein | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | CDKN1A,IFIT1,IL1A,IL24,MX1,OAS2,RGS16,TXNRD1 | 295 (10) |
| KIT | -2.80e-01 | transmembrane receptor | NA | NA | 0.0e+00 | BCL2L1,C3AR1,CCL2,Ccl2,CD274,CXCL10,CXCL3,CXCR4,HDC,HMOX1,Igtp,IL4R,ITGA2B,LGALS3,LIF,MYC,SOCS2,SOCS3,STAT1 | 492 (19) |
| HNRNPA2B1 | -2.90e-01 | other | NA | NA | 0.0e+00 | ABCB1,ADGRG2,ADORA2B,BCL2L1,CA12,CEMIP,CTSV,ERBB3,HIPK2,LPAR1,MMD,MUC13,MYC,NPR3,NTRK3,P4HA1,PGM2L1,SETBP1,SYT1,TFPI2,TOX3,UBXN10 | NA |
| ETS | NA | group | NA | NA | 0.0e+00 | C3AR1,FOS,IL12B,ITGA2B,JAK3,LTB,SERPINE1,TIMP1 | NA |
| GNB2 | 1.00e-01 | enzyme | NA | NA | 0.0e+00 | CCL4,CD83,CDKN1A,CREM,CXCL3,DUSP1,FOSL2,IER3,IFITM5,IL1R2 | 380 (14) |
| Histone h4 | NA | group | NA | NA | 0.0e+00 | ABCB1,CCL4,CD69,CDKN1A,CIITA,CXCL10,CXCL3,DIO1,FASN,FOS,GADD45B,IL1A,MMP9,Mt1,NEDD4L,PTGS2,RASGRP1,SELE,SOCS3,SPHK1,TBX6,TNFSF10 | 473 (18) |
| HPSE | 2.20e-01 | enzyme | NA | NA | 0.0e+00 | CCL2,F3,IRS1,MMP9,PLAUR,PTGS2 | 393 (18) |
| GNB1 | 8.00e-02 | enzyme | NA | NA | 0.0e+00 | CCL4,CD83,CDKN1A,CREM,CXCL3,DUSP1,FOSL2,IER3,IFITM5,IL1R2 | 391 (17) |
| CSF3R | -8.60e-01 | transmembrane receptor | NA | NA | 0.0e+00 | CD14,CSF3R,FOS,GFI1,Meis1,MYC,SELE | 453 (19) |
| BSCL2 | 1.20e-01 | other | NA | NA | 0.0e+00 | ANKRD1,Ccl2,CLEC10A,IER3,IL33,LGALS12,LPIN1,NAT8L,PNPLA2,PPARGC1B,PTGS2,RSAD2,TIMP1 | 394 (11) |
| ADRA1B | 5.30e-01 | G-protein coupled receptor | NA | NA | 0.0e+00 | ADRA1A,ADRA1D,CDKN1A,CEBPD,CREM,CTSV,DUSP1,FOS,LIF,LOX,PRRX1 | 473 (18) |
| RSC1A1 | NA | other | NA | NA | 0.0e+00 | SLC28A1,SLC28A2,SLC28A3,SLC5A1 | NA |
| KCNE3 | 2.10e-01 | ion channel | NA | NA | 0.0e+00 | APOLD1,CCL17,Csprs (includes others),CSRNP1,IRF4,KCNK5,NFIL3,OSGIN1,PER1,PTGS2,Sik1,SLC2A5,TNFAIP6 | NA |
| RXRG | -2.50e-01 | ligand-dependent nuclear receptor | NA | NA | 0.0e+00 | CCL19,CCL24,CCL28,CXCL2,CXCL3,FABP3,IL33,PCK1,PDK4,TIMP3,TNFSF8,XCL1 | 113 (3) |
| MAZ | -2.00e-01 | transcription regulator | NA | NA | 0.0e+00 | ATF3,CCL24,CCL28,CDKN1A,CXCL2,LTA,MMP9,MYC,TNFSF10,TNFSF8 | 437 (16) |
| EIF2S1 | 3.00e-02 | translation regulator | NA | NA | 0.0e+00 | ATF4,GADD45A,GCLC,HHIPL1,HMOX1,IFRD1,MAP1LC3B,NUPR1,SESN2,SYBU,TGM1 | NA |
| TBP | -2.00e-02 | transcription regulator | NA | NA | 0.0e+00 | ABCB1,BCL2A1,CDKN1A,EDNRA,FOS,IER3,MEOX2,MYC,NFKBIA,PPP2R2B,PTGS2,TGFA,XDH | 557 (23) |
| L-ornithine | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | ARG2,CDKN1A,PNPLA2 | NA |
| defibrotide | NA | biologic drug | NA | NA | 0.0e+00 | F3,PLAT,SERPINE1 | NA |
| ELL | 6.50e-01 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,FOS,MYC | 517 (21) |
| PKC delta V1-1 peptide 8-17 | NA | chemical - kinase inhibitor | NA | NA | 0.0e+00 | CCL2,Ccl2,CXCL3 | 324 (9) |
| miR-296-3p (miRNAs w/seed AGGGUUG) | NA | mature microRNA | NA | NA | 0.0e+00 | CREB1,DOK2,JUNB | NA |
| L-JNK inhibitor I | NA | chemical reagent | NA | NA | 0.0e+00 | BMP6,HMOX1,SPHK1 | NA |
| IGF2BP2 | 3.10e-01 | translation regulator | NA | NA | 0.0e+00 | CCL2,Ccl2,LIMS2,TRIM54 | NA |
| 4-coumaric acid | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CDKN1A,MYC,ODC1,PTGS2 | 294 (7) |
| NR2F6 | -1.30e-01 | ligand-dependent nuclear receptor | NA | NA | 0.0e+00 | CCL24,CCL28,CXCL3,IL12B,IL33,ITGB7,XCL1 | NA |
| ATP8B1 | 1.60e-01 | transporter | NA | NA | 0.0e+00 | ABCB11,DNAH2,DNAH6,DNALI1,EFHC1 | NA |
| FANCC | -4.70e-01 | other | NA | NA | 0.0e+00 | ATP1B1,CYP7B1,FZD9,IFI44L,MX1,PCLO,PRKCB,PTGS2,PTPRC,PTX3,RND3,WNT5A | 200 (3) |
| SMARCA1 | -8.00e-01 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,GADD45A,MYC,SFN | 387 (7) |
| BLM | 1.00e-02 | enzyme | NA | NA | 0.0e+00 | CDKN1A,IFI44L,IFIT1,MX1 | 337 (7) |
| danusertib | NA | chemical drug | NA | NA | 0.0e+00 | BCL2L1,CDKN1A,GADD45A | 337 (11) |
| miR-27a-5p (miRNAs w/seed GGGCUUA) | NA | mature microRNA | NA | NA | 0.0e+00 | CX3CR1,GZMB,PRF1 | NA |
| 17-epi-resolvin D1 | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CXCL2,CXCL3,PTGS2 | 288 (14) |
| BICD2 | 2.10e-01 | other | NA | NA | 0.0e+00 | CXCL10,IFIT1,STAT1 | NA |
| ACP1 | NA | phosphatase | NA | NA | 0.0e+00 | EPHA2,FOS,MYC | 394 (20) |
| stilbene | NA | chemical reagent | NA | NA | 0.0e+00 | CXCL10,IFIT1,ISG15 | NA |
| cadmium sulfate | NA | chemical toxicant | NA | NA | 0.0e+00 | HMOX1,Mt1,PTGS2 | 204 (7) |
| iodixanol | NA | chemical drug | NA | NA | 0.0e+00 | LCN2,SELP,SERPINE1 | NA |
| TLE1 | 3.00e-01 | transcription regulator | NA | NA | 0.0e+00 | ATF3,BCL2A1,DUSP1,FOS,NUPR1 | 311 (7) |
| FGFR4 | -7.20e-01 | kinase | NA | NA | 0.0e+00 | BCL2L1,CDKN1A,FASN,FOS,KDR,LPAR1,NR0B2,SERPINE1 | 430 (21) |
| IFNAR2 | 1.10e-01 | transmembrane receptor | NA | NA | 0.0e+00 | CXCL10,GBP4,HSH2D,IFI44,ISG15,OAS2,TNFSF10,UBA7,USP18 | 344 (13) |
| Agtr1b | -4.00e-02 | G-protein coupled receptor | NA | NA | 0.0e+00 | F3,FOS,PTGS2,SLC6A2 | 293 (17) |
| MPL | -3.40e-01 | transmembrane receptor | NA | NA | 0.0e+00 | FOS,ITGA2B,MYC,SELP | 375 (20) |
| PADI4 | 2.50e-01 | enzyme | NA | NA | 0.0e+00 | BCL2L1,CDKN1A,GADD45A,OSGIN1,TNFRSF12A | 252 (7) |
| SP2 | 3.30e-01 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,FOS,GNAI2,SERPINE1,SERPINH1 | NA |
| PLAGL1 | -4.10e-01 | transcription regulator | NA | NA | 0.0e+00 | ADCYAP1R1,CCL24,CCL28,CDKN1A,LTA,RASGRF1,TNFSF8 | NA |
| OVA-8 | NA | chemical reagent | NA | NA | 0.0e+00 | BCL2L1,FOS,GADD45B,IL2RB,MYC,NFKBIA,SFPQ,XPO1 | NA |
| CERK | 2.90e-01 | kinase | NA | NA | 0.0e+00 | ACKR4,CCL2,CCL28,CCL4,CCR3,CXCL2,CXCR4,TNFSF10 | 423 (10) |
| PURA | -2.10e-01 | transcription regulator | NA | NA | 0.0e+00 | AR,CDKN1A,ITGAD,MYC,SPN | 417 (13) |
| mir-194 | NA | microRNA | NA | NA | 0.0e+00 | DACH1,PLAUR,SLC7A5,SOCS2,THBS1 | NA |
| NAP1L1 | -1.00e-02 | other | NA | NA | 0.0e+00 | ALB,CXCR4,HNF4A,WNT7A | NA |
| rhesus theta-defensin 1 | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | Ccl2,CXCL2,IL12B,IL1A | 420 (19) |
| AGRP | 3.50e-01 | other | NA | NA | 0.0e+00 | DIO2,FOS,TRH,UBC | 89 (3) |
| ENO1 | 1.30e-01 | enzyme | NA | NA | 0.0e+00 | BCL2L1,MYC,PTGS2,SELE | 423 (20) |
| IL9R | -2.00e-02 | transmembrane receptor | NA | NA | 0.0e+00 | GZMA,JUNB,MYC,SELL | 230 (7) |
| Igkv1-117 | NA | other | NA | NA | 0.0e+00 | CDKN1A,FOSL2,JUNB,MYC | 363 (15) |
| PGK1 | 1.70e-01 | kinase | NA | NA | 0.0e+00 | CXCR4,KLF15,MAP2K6,PLG | NA |
| NFKBIE | -1.00e-01 | transcription regulator | NA | NA | 0.0e+00 | CCL2,CXCL3,LIF,SELE | 287 (11) |
| IRF2BP1 | -4.00e-02 | transcription regulator | NA | NA | 0.0e+00 | ADAMTS1,ATF3,CCL2,DUSP1,EPGN,FOS,INHBA,OSR2 | NA |
| tauromuricholic acid | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | ABCB1,ABCC2,CPT1A | NA |
| UMN627 | NA | chemical reagent | NA | NA | 0.0e+00 | CXCL2,CXCL3,CXCL6 | NA |
| Cpla2 | NA | group | NA | NA | 0.0e+00 | AR,MYC,PTGS2 | 430 (19) |
| Gata | NA | group | NA | NA | 0.0e+00 | EDN1,ITGA2B,KDR | NA |
| SIRT4 | 1.10e-01 | enzyme | NA | NA | 0.0e+00 | ADGRE1,Ccl2,HMOX1 | 334 (13) |
| RAB23 | -3.90e-01 | enzyme | NA | NA | 0.0e+00 | Acan,COL2A1,GLI1 | 326 (5) |
| betulin | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | BCL2L1,PTGS2,TIMP1 | 277 (9) |
| EIF3I | 3.90e-01 | translation regulator | NA | NA | 0.0e+00 | MYC,PTGS2,SERPINE1 | 295 (7) |
| miR-370-3p (and other miRNAs w/seed CCUGCUG) | NA | mature microRNA | NA | NA | 0.0e+00 | MAP3K8,PTPRN,WNT7A | NA |
| ARLNC1 | NA | other | NA | NA | 0.0e+00 | AR,FKBP5,STEAP2 | 369 (7) |
| benidipine | NA | chemical drug | NA | NA | 0.0e+00 | CDKN1A,SELE,SELP | NA |
| pegintron | NA | biologic drug | NA | NA | 0.0e+00 | CXCL10,ISG15,USP18 | 184 (9) |
| aurothiomalate | NA | chemical drug | NA | NA | 0.0e+00 | GCLC,HAS1,HMOX1 | 408 (15) |
| RNASEH2A | -3.40e-01 | enzyme | NA | NA | 0.0e+00 | CXCL10,GBP2,IFI44,ISG15,JUNB,NFKBIA,PTGS2,RSAD2,USP18 | NA |
| desoxycorticosterone | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | Ccl2,CXCL2,FOS,PTGS2,SERPINE1 | 382 (18) |
| tetrodotoxin | NA | chemical drug | NA | NA | 0.0e+00 | ATP1B1,BMP3,CAMK1D,CNTN3,CNTNAP1,CPNE5,ESRRG,GNRH1,IFRD1,KCNA2,LGI1,LURAP1L,Mt1,PTGS2,RNF152,TLL1,TRIM14 | 153 (7) |
| SOD1 | 1.80e-01 | enzyme | NA | NA | 0.0e+00 | ADORA2B,ATF4,ATP1A1,BCL2L1,CD14,FOS,FOSL2,GCLC,H2-T24,HMOX1,HPCAL1,IFI44,INHBA,ISG15,JUNB,LIMK1,MAOB,MMP9,Mt1,NFIL3,OAS2,PRRX1,PTGS2,RBM3,RSAD2,SCN1B,SLC38A3,USP18 | 455 (21) |
| E2F5 | 3.70e-01 | transcription regulator | NA | NA | 0.0e+00 | AURKB,CCNA1,CDKN1A,MYC,MYCN,SERPINE1 | NA |
| acyline | NA | biologic drug | NA | NA | 0.0e+00 | Bhlhe41,DUSP1,FGFR4,FOS,GADD45B,GADD45G,JUNB,MYC,OSBPL6,Sik1,SLC16A3,SLC7A1,THRB,ZBTB16 | 365 (13) |
| pituitary adenylate cyclase-activating polypeptide | NA | biologic drug | NA | NA | 0.0e+00 | ACER2,ADGRL2,EPHA4,ERRFI1,FOSL1,MMD,MYCN,SMIM3 | NA |
| LGALS7/LGALS7B | 3.30e-01 | other | NA | NA | 0.0e+00 | MAOB,MMP9,RYR2,SERPINE1 | 399 (15) |
| AFP | 0.00e+00 | transporter | NA | NA | 0.0e+00 | FOS,GNRH1,MMP9,TNFRSF12A | 397 (11) |
| KLF7 | NA | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,IFIT1,MX1,TNFSF10 | NA |
| MAPK6 | 2.60e-01 | kinase | NA | NA | 0.0e+00 | DIO2,MMP9,PNPLA2,PPARA | 403 (15) |
| Ncoa6 | NA | transcription regulator | NA | NA | 0.0e+00 | FASN,FOS,SERPINE1,TGFA | NA |
| methylnitrosourea | NA | chemical toxicant | NA | NA | 0.0e+00 | ATP1A1,CXCL3,FASN,GNAI2,KDR,PLAUR,TIMP3 | 461 (18) |
| ATN1 | 1.30e-01 | transcription regulator | NA | NA | 0.0e+00 | ARHGEF28,ATP1A1,ATP1B1,BHLHE40,BMP3,CA4,GAS7,GRK5,HPCAL1,KCNA2,MCAM,PCTP,PRKCG,RGS16,Sik1,SOCS2 | NA |
| PRDM5 | 1.40e-01 | transcription regulator | NA | NA | 0.0e+00 | ACSBG1,CDC42EP4,CEMIP,EDNRA,GADD45B,IL6R,INTS3,MYC,PAX5,SOCS3,SOX2,TINAGL1 | NA |
| corticosteroid | NA | chemical drug | NA | NA | 0.0e+00 | AQP1,CD69,CLCA1,DUSP1,FKBP5,GZMA,HIPK2,IL1R2,MAFF,STK17B,XPO1 | 241 (8) |
| thyroid hormone receptor | NA | group | NA | NA | 0.0e+00 | CPT1A,FOS,KRT17,MYC,NR5A2,POR | 428 (23) |
| SLC9A3 | 1.80e-01 | ion channel | NA | NA | 0.0e+00 | Igtp,Mt1,SLC26A3,SLC5A1,STAT1,UPP1 | NA |
| Cobra Venom Factor | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | APCS,CRP,SELP | 271 (9) |
| norethindrone acetate | NA | chemical drug | NA | NA | 0.0e+00 | F3,PLAT,SERPINE1 | 411 (13) |
| Cbp/p300-Maf-Nfe2l2 | NA | complex | NA | NA | 0.0e+00 | FTL,GCLC,HMOX1 | NA |
| CDHR1 | -6.40e-01 | other | NA | NA | 0.0e+00 | CEBPD,OSMR,SOCS3 | NA |
| Integrin alpha 4 beta 1 | NA | complex | NA | NA | 0.0e+00 | BCL2L1,F3,PDGFB | 362 (14) |
| RGMB | -1.90e-01 | other | NA | NA | 0.0e+00 | CXCL2,CXCL3,LCN2 | 288 (6) |
| KMT2C | -3.10e-01 | transcription regulator | NA | NA | 0.0e+00 | CCL2,MMP9,NR0B2 | 216 (7) |
| CLEC12A | -2.60e-01 | other | NA | NA | 0.0e+00 | ISG15,RSAD2,USP18 | 248 (14) |
| mir-548 | NA | microRNA | NA | NA | 0.0e+00 | AR,CDKN1A,MMP9 | 265 (10) |
| NUCB2 | 3.00e-01 | other | NA | NA | 0.0e+00 | FOS,PTGS2,TRH | 556 (21) |
| ABHD5 | -9.00e-02 | enzyme | NA | NA | 0.0e+00 | PDK4,PNPLA2,TGM1 | 417 (14) |
| carboxymethylflavin | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | GLI1,MMP9,TIMP1 | 243 (7) |
| formylmethylflavin | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | GLI1,MMP9,TIMP1 | 243 (7) |
| BCL2A1 | -6.10e-01 | other | NA | NA | 0.0e+00 | BCL2A1,BCL2L1,CD69 | 257 (7) |
| gelam honey | NA | chemical reagent | NA | NA | 0.0e+00 | BCL2L1,NFKBIA,PTGS2 | 324 (9) |
| coxsackievirus A21 | NA | biologic drug | NA | NA | 0.0e+00 | CD274,CXCL10,LAG3 | NA |
| pyridoxal phosphate-6-azophenyl-2’,4’-disulfonic acid | NA | chemical reagent | NA | NA | 0.0e+00 | Ccl2,PTGS2,THBS1 | 393 (14) |
| XCT790 | NA | chemical reagent | NA | NA | 0.0e+00 | CDKN1A,MAOB,PDK4 | 94 (4) |
| saquinavir | NA | chemical drug | NA | NA | 0.0e+00 | MMP9,MYC,NFKBIA | 416 (18) |
| EPZ005687 | NA | chemical - protease inhibitor | NA | NA | 0.0e+00 | HSD11B2,MYC,NGFR | NA |
| lumichrome | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | GLI1,MMP9,TIMP1 | 243 (7) |
| zofenopril | NA | chemical drug | NA | NA | 0.0e+00 | Ccl2,HMOX1,TIMP1 | 216 (7) |
| UC2288 | NA | chemical reagent | NA | NA | 0.0e+00 | Acan,COL2A1 | NA |
| 2-methylthio-ATP | NA | chemical reagent | NA | NA | 0.0e+00 | FOS,SERPINE1 | 443 (13) |
| L-leucine | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | ALB,CXCL2 | NA |
| arbutin | NA | chemical drug | NA | NA | 0.0e+00 | CDKN1A,PTGS2 | NA |
| 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | ABCB11,NR0B2 | NA |
| cholestane-3,7,26-triol | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | ABCB11,NR0B2 | NA |
| 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | ABCB11,NR0B2 | NA |
| 3,7,12-trihydroxycoprostanic acid | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | ABCB11,NR0B2 | NA |
| cytochrome-c oxidase | NA | complex | NA | NA | 0.0e+00 | AQP1,MAOA | NA |
| KCN1 | NA | chemical reagent | NA | NA | 0.0e+00 | P4HA1,P4HA2 | NA |
| CC-885 | NA | chemical reagent | NA | NA | 0.0e+00 | ATF3,ATF4 | NA |
| MSK1/2 | NA | group | NA | NA | 0.0e+00 | DUSP1,FOS | 342 (7) |
| guggulu extract | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | ABCB11,NR0B2 | NA |
| 2,4,5-trichlorophenoxyacetic acid | NA | chemical toxicant | NA | NA | 0.0e+00 | ABCC2,GCLC | NA |
| polytef | NA | chemical drug | NA | NA | 0.0e+00 | F3,SELE | NA |
| CDCA7L | -1.00e-01 | other | NA | NA | 0.0e+00 | MAOA,MAOB | NA |
| ACER3 | -1.50e-01 | enzyme | NA | NA | 0.0e+00 | ACER2,CDKN1A | NA |
| OMG | 1.90e-01 | G-protein coupled receptor | NA | NA | 0.0e+00 | FOS,MYC | NA |
| 3,4-dihydroxyphenylethanol | NA | chemical drug | NA | NA | 0.0e+00 | MMP9,PTGS2 | 385 (13) |
| ASNS | 1.20e-01 | enzyme | NA | NA | 0.0e+00 | MYC,SLC7A5 | NA |
| PTPN13 | 1.60e-01 | phosphatase | NA | NA | 0.0e+00 | BCL2L1,MYC | 393 (18) |
| mir-331 | NA | microRNA | NA | NA | 0.0e+00 | MYC,PLAUR | NA |
| IGK | NA | other | NA | NA | 0.0e+00 | BCL2L1,CCL2 | 330 (11) |
| Ighe | NA | other | NA | NA | 0.0e+00 | CXCL3,CXCL6 | NA |
| POLDIP3 | 1.00e-02 | other | NA | NA | 0.0e+00 | CDKN1A,ISG15 | NA |
| FBXW8 | 1.60e-01 | enzyme | NA | NA | 0.0e+00 | IRS1,MAP4K1 | NA |
| GAD1 | -1.60e-01 | enzyme | NA | NA | 0.0e+00 | FOS,GNRH1 | 328 (14) |
| MYBPC1 | 4.00e-02 | other | NA | NA | 0.0e+00 | Ccl2,IL1A | NA |
| KHDRBS2 | -2.00e-02 | other | NA | NA | 0.0e+00 | CDKN1A,STAT1 | NA |
| STAMBP | 1.50e-01 | enzyme | NA | NA | 0.0e+00 | CXCR4,MYC | 297 (11) |
| 2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide | NA | chemical reagent | NA | NA | 0.0e+00 | AURKB,MYC | NA |
| 14,15-epoxyeicosa-5(Z)-enoic acid | NA | chemical reagent | NA | NA | 0.0e+00 | Ccl2,SELE | 216 (7) |
| CRTAP | NA | other | NA | NA | 0.0e+00 | CDKN1A,SERPINE1 | 250 (10) |
| RNF11 | NA | enzyme | NA | NA | 0.0e+00 | MMP9,SERPINE1 | 249 (10) |
| CLEC2D | NA | transmembrane receptor | NA | NA | 0.0e+00 | CD83,CXCR4 | NA |
| ZFYVE16 | -2.70e-01 | other | NA | NA | 0.0e+00 | CDKN1A,SERPINE1 | 402 (13) |
| ERH | 6.00e-02 | other | NA | NA | 0.0e+00 | SOCS3,WNT5A | NA |
| GSK-2879552 | NA | chemical drug | NA | NA | 0.0e+00 | CD274,MYC | 215 (7) |
| securinine | NA | chemical reagent | NA | NA | 0.0e+00 | CDKN1A,TP73 | NA |
| HO-3867 | NA | chemical reagent | NA | NA | 0.0e+00 | BCL2L1,TGFA | NA |
| 3-iodobenzylguanidine | NA | chemical drug | NA | NA | 0.0e+00 | MYC,MYCN | NA |
| NPC 15437 | NA | chemical drug | NA | NA | 0.0e+00 | FOS,GNRH1 | 233 (7) |
| fostriecin | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | AR,GNAI2 | NA |
| sarpogrelate | NA | chemical drug | NA | NA | 0.0e+00 | F3,SERPINE1 | NA |
| methiothepin | NA | chemical drug | NA | NA | 0.0e+00 | F3,SERPINE1 | 230 (7) |
| sibutramine | NA | chemical drug | NA | NA | 0.0e+00 | APOB,SERPINE1 | NA |
| mefenamic acid | NA | chemical drug | NA | NA | 0.0e+00 | BCL2L1,SELL | 308 (7) |
| milrinone | NA | chemical drug | NA | NA | 0.0e+00 | CREM,F3 | 290 (13) |
| sepiapterin | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | KDR,LCN2 | 281 (7) |
| hexaarginine-neomycin B conjugate | NA | chemical reagent | NA | NA | 0.0e+00 | CD8A,CXCR4 | NA |
| nisoldipine | NA | chemical drug | NA | NA | 0.0e+00 | CREB1,FOS | NA |
| barium chloride | NA | chemical toxicant | NA | NA | 0.0e+00 | LOX,LOXL1 | NA |
| NVP-BHG712 | NA | chemical drug | NA | NA | 0.0e+00 | AR,MYC | NA |
| teleocidins | NA | chemical toxicant | NA | NA | 0.0e+00 | FOS,ODC1 | NA |
| 3alpha,7alpha-dihydroxy-5beta-cholestanic acid | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | ABCB11,NR0B2 | NA |
| tibolone | NA | chemical drug | NA | NA | 0.0e+00 | PFKFB3,SERPINE1 | NA |
| interferon beta-1a | NA | biologic drug | NA | NA | 0.0e+00 | CXCR4,GADD45B,GBP5,GZMB,IFIT1,IL2RB,LILRB3,LTB,MMP9,MX1,NFIL3,NFKBIA,PLAUR,STAT1,TNFAIP6 | 192 (9) |
| PIAS2 | -5.00e-02 | transcription regulator | NA | NA | 0.0e+00 | AR,CDKN1A,FOS,SLC11A1 | 511 (22) |
| COPA | 2.00e-02 | transporter | NA | NA | 0.0e+00 | IL12B,IL1A,ISG15,RSAD2 | 456 (20) |
| SETBP1 | -6.00e-01 | transcription regulator | NA | NA | 0.0e+00 | AR,BCL11A,FSTL3,JAK3,KCNJ5,KDR,Meis1,MYC,NTRK3,PDGFB,SIX1 | NA |
| JUN/JUNB/JUND | NA | group | NA | NA | 0.0e+00 | BCL2L1,CREB3L3,FOS,FOSL1,HMOX1,PTPRO | 323 (12) |
| MAP2K2 | 2.30e-01 | kinase | NA | NA | 0.0e+00 | ACSBG1,CDKN1A,FOS,IRS1,ITGA2B,MYC | 468 (21) |
| RPA1 | -1.00e-02 | other | NA | NA | 0.0e+00 | ADGRG5,DLGAP1,FOCAD,RASSF10,SNCAIP | NA |
| ADRA1D | -9.20e-01 | G-protein coupled receptor | NA | NA | 0.0e+00 | CEBPD,CREM,CTSV,DUSP1,FOS,LIF,LOX,PRRX1 | 502 (19) |
| EPOR | -4.00e-02 | transmembrane receptor | NA | NA | 0.0e+00 | BCL2L1,HMOX1,JUNB,MERTK,MYC,SOCS3 | 345 (18) |
| trypsin | NA | group | NA | NA | 0.0e+00 | CDKN1A,F3,FOS,PTGS2 | 431 (17) |
| TWIST | NA | group | NA | NA | 0.0e+00 | CDKN1A,NRP1,SERPINH1,ST8SIA1 | NA |
| S-equol | NA | chemical drug | NA | NA | 0.0e+00 | HMOX1,MMP9,PLAT,SERPINE1 | 506 (24) |
| mangiferin | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | BCL2L1,HMOX1,MMP9,PPARA,PTGS2 | 354 (18) |
| histidinol | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | ATF4,SLC7A1,SLC7A5 | NA |
| Alpha 1 antitrypsin | NA | group | NA | NA | 0.0e+00 | Acan,ADAMTS5,COL2A1 | NA |
| Sphk | NA | group | NA | NA | 0.0e+00 | CCL2,IL33,SELE | 248 (13) |
| 4732491K20Rik | NA | other | NA | NA | 0.0e+00 | Ccl2,PTGS2,SELE | 257 (7) |
| PRMT7 | -7.00e-02 | enzyme | NA | NA | 0.0e+00 | CDKN1A,GADD45B,IRF4 | 343 (15) |
| AKIRIN2 | 1.10e-01 | other | NA | NA | 0.0e+00 | DUSP1,MMP9,MYC | 331 (12) |
| ASPN | 8.00e-02 | other | NA | NA | 0.0e+00 | Acan,COL2A1,PTGS2 | 461 (14) |
| iguratimod | NA | chemical drug | NA | NA | 0.0e+00 | Ccl2,CXCL2,CXCL3 | 389 (18) |
| NUDT16L1 | -1.20e-01 | other | NA | NA | 0.0e+00 | ANKRD1,CDKN1A,EDN1 | NA |
| CCDC50 | NA | other | NA | NA | 0.0e+00 | CXCL2,CXCL3,IL1A | 294 (7) |
| miR-491-5p (and other miRNAs w/seed GUGGGGA) | NA | mature microRNA | NA | NA | 0.0e+00 | AR,BCL2L1,MMP9 | 511 (21) |
| miR-292b-5p (and other miRNAs w/seed CUCAAAA) | NA | mature microRNA | NA | NA | 0.0e+00 | AR,BCL11A,BCL11B | NA |
| MAEL | NA | transcription regulator | NA | NA | 0.0e+00 | MYC,PTGS2,SOX2 | 360 (12) |
| PDE3A | 3.80e-01 | enzyme | NA | NA | 0.0e+00 | CDKN1A,CREM,DUSP1 | 428 (13) |
| TRIM14 | -6.60e-01 | other | NA | NA | 0.0e+00 | GBP5,ISG15,SOCS3 | 242 (7) |
| APOBEC1 | -6.00e-02 | enzyme | NA | NA | 0.0e+00 | APOB,IL12B,PTGS2 | 326 (13) |
| MED13L | 5.50e-01 | other | NA | NA | 0.0e+00 | ANKRD1,LIF,MYC | NA |
| TNFRSF14 | -6.60e-01 | transmembrane receptor | NA | NA | 0.0e+00 | BTLA,F2RL1,MMP9 | 361 (13) |
| CLEC2A | NA | other | NA | NA | 0.0e+00 | BCL2L1,CCL4,CXCL10 | 307 (7) |
| Brd4 | 4.00e-02 | kinase | NA | NA | 0.0e+00 | FOS,NFKBIA,SERPINE1 | 275 (10) |
| PRN694 | NA | chemical drug | NA | NA | 0.0e+00 | CD69,FOS,NFKBIA | 401 (8) |
| enzastaurin | NA | chemical drug | NA | NA | 0.0e+00 | AR,CLDN5,PRKCB | 312 (12) |
| diquat | NA | chemical toxicant | NA | NA | 0.0e+00 | HMOX1,Mt1,TXNRD1 | NA |
| 6-methylsulfinylhexyl isothiocyanate | NA | chemical reagent | NA | NA | 0.0e+00 | GCLC,Gsta1,SELE | 207 (7) |
| phytoestrogen | NA | chemical drug | NA | NA | 0.0e+00 | AR,BMP2,LIF | NA |
| warfarin | NA | chemical drug | NA | NA | 0.0e+00 | MGP,PDGFB,PROCR | NA |
| retroinverso ERG inhibitory peptide 2 | NA | chemical reagent | NA | NA | 0.0e+00 | ADAMTS1,CXCR4,PLAT | NA |
| retroinverso ERG inhibitory peptide 1 | NA | chemical reagent | NA | NA | 0.0e+00 | ADAMTS1,CXCR4,PLAT | NA |
| LY83583 | NA | chemical reagent | NA | NA | 0.0e+00 | CDKN1A,HMOX1,HSD11B2 | 340 (12) |
| flavone | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | BCL2L1,PON1,PTGS2 | 199 (7) |
| sanguinarine | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | CCL2,HMOX1,TIMP1 | 451 (18) |
| dobutamine | NA | chemical drug | NA | NA | 0.0e+00 | CXCL10,CXCL2,HMOX1 | NA |
| N-acetyl-L-aspartic acid | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | ASPA,CD163,FASN | NA |
| ADAM10 | -8.00e-02 | peptidase | NA | NA | 0.0e+00 | ATP6V0A4,CALCRL,CCL4,CDHR1,DLGAP1,FOS,GADD45G,Hrg,INHBA,ITIH4,LCK,MKKS,Pln,S100A8,SYT1,XCL1 | 216 (7) |
| Rac | NA | group | NA | NA | 1.0e-02 | BMP2,CCL2,FOS,PTGS2 | 452 (21) |
| Adaptor protein 1 | NA | complex | NA | NA | 1.0e-02 | CR2,MMP9,MYC,PTGS2 | NA |
| CARD14 | 4.50e-01 | other | NA | NA | 1.0e-02 | CXCL2,CXCL3,LCN2,S100A8 | 216 (7) |
| diacylglycerol | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | ODC1,PRKCB,PRKCH,RASGRP1 | 163 (7) |
| ZNF148 | -7.00e-02 | transcription regulator | NA | NA | 1.0e-02 | BCL2L1,CDKN1A,LCK,ODC1,STAT1 | 418 (13) |
| DYSF | 9.10e-01 | other | NA | NA | 1.0e-02 | ANKRD1,CD83,CTSH,CTSV,CXCL10,ERRFI1,FASN,FTL,GABARAPL1,LGALS3,TCEAL9,TIMP1 | NA |
| FECH | 1.00e-02 | enzyme | NA | NA | 1.0e-02 | Ccl2,Cyp3a25 (includes others),CYP7B1,HMOX1,SLC10A1,Slco1a1 | NA |
| arsenic | NA | chemical toxicant | NA | NA | 1.0e-02 | ERN1,FOS,FTL,GCLC,Mt1,TGFA | 432 (22) |
| ADRA1A | -9.80e-01 | G-protein coupled receptor | NA | NA | 1.0e-02 | CEBPD,CREM,CTSV,DUSP1,FOS,LIF,LOX,PRRX1 | 499 (21) |
| POU2F1 | -9.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CD79A,CD79B,CDO1,CR2,CRP,DDIT4,ELK3,GADD45A,GBP2,GNRH1,SELE,SESN2,TIMP3,TNFRSF14 | 242 (7) |
| Fibrin | NA | complex | NA | NA | 1.0e-02 | COL2A1,F3,KDR,NGFR,SERPINE1 | 383 (18) |
| ELK4 | 1.40e-01 | transcription regulator | NA | NA | 1.0e-02 | CCL2,EGR3,FOS,FOSL1,JUNB | 298 (12) |
| HRH3 | -2.90e-01 | G-protein coupled receptor | NA | NA | 1.0e-02 | Acot1,CXCL10,CXCL3,ITIH4,NPR3,RBP4,S100A8 | NA |
| ARRB1 | -7.00e-02 | transcription regulator | NA | NA | 1.0e-02 | Ccl2,F3,FASN,JUNB,MYC,PTGS2,SERPINE1 | 438 (18) |
| L-proline | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | ALB,CDKN1A,LIF | 252 (7) |
| Li+ | NA | chemical reagent | NA | NA | 1.0e-02 | EDN1,FOS,PCK1 | 382 (12) |
| N-Cadherin | NA | group | NA | NA | 1.0e-02 | CCL2,CDKN1A,MMP9 | 389 (14) |
| GCS-100 | NA | chemical drug | NA | NA | 1.0e-02 | BCL2L1,CDKN1A,LGALS3 | 316 (8) |
| Y-320 | NA | chemical reagent | NA | NA | 1.0e-02 | CXCL10,CXCL2,CXCL3 | NA |
| CENPN | 2.00e-02 | other | NA | NA | 1.0e-02 | HK2,MYC,PFKFB3 | NA |
| CHCHD5 | 6.00e-02 | other | NA | NA | 1.0e-02 | CPT1B,FASN,PPARA | NA |
| SLC39A8 | 3.90e-01 | transporter | NA | NA | 1.0e-02 | ADAMTS5,IL12B,MMP9 | NA |
| ADGRF5 | 2.30e-01 | G-protein coupled receptor | NA | NA | 1.0e-02 | Ccl2,CXCL3,MMP9 | 268 (15) |
| GSK0660 | NA | chemical reagent | NA | NA | 1.0e-02 | PDK4,THBS1,TRIM63 | 392 (13) |
| BAG6 | 1.60e-01 | enzyme | NA | NA | 1.0e-02 | CDKN1A,SERPINE1,SESN1 | 419 (15) |
| THRSP | -3.80e-01 | other | NA | NA | 1.0e-02 | DIO1,FASN,PCK1 | NA |
| ETV3 | 3.80e-01 | transcription regulator | NA | NA | 1.0e-02 | CCL2,MYC,XCL1 | NA |
| ATF7 | -2.70e-01 | transcription regulator | NA | NA | 1.0e-02 | DUSP1,DUSP8,SELE | NA |
| CYP3A4 | -7.80e-01 | enzyme | NA | NA | 1.0e-02 | GCLC,HMOX1,Slco1a1 | 103 (3) |
| TBL1X | -3.30e-01 | transcription regulator | NA | NA | 1.0e-02 | CXCL2,DIO1,USP18 | 192 (8) |
| SNW1 | 1.30e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,MMP9,SERPINE1 | 443 (14) |
| IKBKB-DT | NA | other | NA | NA | 1.0e-02 | IL1A,MMP9,MYC | 200 (7) |
| LINC01612 | NA | other | NA | NA | 1.0e-02 | ATF3,CDKN1A,MYC | 420 (12) |
| SULF1 | -9.00e-02 | enzyme | NA | NA | 1.0e-02 | Acan,ADAMTS5,COL2A1 | 224 (7) |
| TBL1XR1 | -3.20e-01 | transcription regulator | NA | NA | 1.0e-02 | CXCL2,DIO1,USP18 | 192 (7) |
| ULBP1 | NA | transmembrane receptor | NA | NA | 1.0e-02 | CCL4,CD69,CD83 | 330 (7) |
| itraconazole | NA | chemical drug | NA | NA | 1.0e-02 | AGR2,CD14,GLI1 | 247 (7) |
| GW 5074 | NA | chemical drug | NA | NA | 1.0e-02 | BCL2L1,PTGS2,SERPINE1 | 427 (20) |
| ETV6-NTRK3 | NA | fusion gene/product | NA | NA | 1.0e-02 | Igtp,Oasl2,STAT1 | 153 (7) |
| N-methyl-3,4-methylenedioxyamphetamine | NA | chemical drug | NA | NA | 1.0e-02 | BCL2L1,FOS,Mt1 | 491 (19) |
| theaflavin | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | AR,CCL2,CDKN1A | 449 (19) |
| tosyllysine chloromethyl ketone | NA | chemical - protease inhibitor | NA | NA | 1.0e-02 | NFKBIA,PTGS2,SPN | 324 (9) |
| amphotericin B | NA | chemical drug | NA | NA | 1.0e-02 | CCL2,CCL4,LCN2,TIMP1 | 487 (17) |
| PLN | NA | transporter | NA | NA | 1.0e-02 | AK1,ATP1A1,BLK,DLL1,FABP3,GNAI2,KCNJ12,PRKCB,RYR2 | NA |
| KDM6B | 1.10e-01 | enzyme | NA | NA | 1.0e-02 | GBP7,Igtp,IL12B,ITGA2B,NGFR,Oasl2 | NA |
| NRG2 | -5.10e-01 | growth factor | NA | NA | 1.0e-02 | CXCL6,EDN1,HK2,HMOX1,IER3,JUNB,PHKG1,PLG,SOX2 | 344 (11) |
| Cdkn1c | 3.70e-01 | other | NA | NA | 1.0e-02 | CDKN1A,CXCR4,NGFR,Pmaip1,PPP1R13B | 219 (4) |
| thioguanine | NA | chemical drug | NA | NA | 1.0e-02 | MYC,TNFSF10 | NA |
| mycosporine-like amino acid | NA | chemical reagent | NA | NA | 1.0e-02 | CEMIP,FOS | NA |
| VBIT-4 | NA | chemical reagent | NA | NA | 1.0e-02 | ISG15,USP18 | NA |
| tolylfluanid | NA | chemical toxicant | NA | NA | 1.0e-02 | FASN,LPIN1 | NA |
| BBS1 | 2.20e-01 | other | NA | NA | 1.0e-02 | ADRA1A,ADRA1D | NA |
| AKIP1 | -1.20e-01 | other | NA | NA | 1.0e-02 | NFKBIA,PTGS2 | 358 (11) |
| ZNF451 | 2.60e-01 | enzyme | NA | NA | 1.0e-02 | CDKN1A,SERPINE1 | NA |
| BCS1L | -3.60e-01 | other | NA | NA | 1.0e-02 | ATF4,PPARA | NA |
| KLHL21 | 2.80e-01 | enzyme | NA | NA | 1.0e-02 | DUSP1,NFKBIA | NA |
| TCF4-CTNNβ | NA | complex | NA | NA | 1.0e-02 | ID4,MYC | NA |
| methylamphotericin B | NA | chemical drug | NA | NA | 1.0e-02 | LCN2,TIMP1 | NA |
| ATP1A2 | 2.00e-01 | transporter | NA | NA | 1.0e-02 | ATP1A1,FOS | NA |
| ferric carboxymaltose | NA | chemical drug | NA | NA | 1.0e-02 | Acot1,CPT1B | NA |
| Gap | NA | group | NA | NA | 1.0e-02 | FOS,RASGRF1 | 159 (7) |
| CSNK1E | 1.60e-01 | kinase | NA | NA | 1.0e-02 | PER1,SERPINE1 | NA |
| RNF144B | 4.80e-01 | enzyme | NA | NA | 1.0e-02 | CDKN1A,TP73 | 337 (9) |
| PMEPA1 | 2.60e-01 | other | NA | NA | 1.0e-02 | AR,CDKN1A | 20 (3) |
| GAPLINC | NA | other | NA | NA | 1.0e-02 | CXCL10,TNFSF10 | NA |
| YARS1 | NA | enzyme | NA | NA | 1.0e-02 | F3,NFKBIA | 220 (9) |
| riociguat | NA | chemical drug | NA | NA | 1.0e-02 | SERPINE1,TIMP1 | 200 (7) |
| miR-509-3p (miRNAs w/seed GAUUGGU) | NA | mature microRNA | NA | NA | 1.0e-02 | AR,NTRK3 | NA |
| RPS14 | 1.40e-01 | translation regulator | NA | NA | 1.0e-02 | MYC,S100A8 | NA |
| aurora kinase inhibitor III | NA | chemical - kinase inhibitor | NA | NA | 1.0e-02 | CREM,FOS | NA |
| DOK2 | -9.20e-01 | other | NA | NA | 1.0e-02 | DOK2,MYC | NA |
| COL7A1 | 5.80e-01 | other | NA | NA | 1.0e-02 | THBS1,WNT5A | NA |
| SLC2A5 | 7.10e-01 | transporter | NA | NA | 1.0e-02 | SLC26A3,SLC2A5 | NA |
| STRAP | 2.60e-01 | other | NA | NA | 1.0e-02 | MYC,SERPINE1 | 263 (13) |
| TOR2A | 1.60e-01 | other | NA | NA | 1.0e-02 | FOS,MYC | NA |
| ADCY6 | 6.00e-02 | enzyme | NA | NA | 1.0e-02 | ATF3,Pln | 307 (7) |
| GCNT1 | -2.50e-01 | enzyme | NA | NA | 1.0e-02 | FOS,SPN | 220 (6) |
| ZNF350 | NA | transcription regulator | NA | NA | 1.0e-02 | GADD45A,MMP9 | NA |
| TXNDC5 | 1.40e-01 | enzyme | NA | NA | 1.0e-02 | MMP9,SELP | 213 (7) |
| ACS84 | NA | chemical reagent | NA | NA | 1.0e-02 | GCLC,HMOX1 | 207 (7) |
| INHBC | -3.20e-01 | growth factor | NA | NA | 1.0e-02 | INHBA,JUNB | NA |
| HES6 | 1.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,HNF4A | NA |
| ERC1 | -1.60e-01 | other | NA | NA | 1.0e-02 | NFKBIA,PTGS2 | 417 (17) |
| POLG2 | 3.20e-01 | enzyme | NA | NA | 1.0e-02 | RSAD2,USP18 | NA |
| MXD3 | NA | transcription regulator | NA | NA | 1.0e-02 | MYCN,ODC1 | NA |
| mir-297 | NA | microRNA | NA | NA | 1.0e-02 | AR,JUNB | NA |
| mercaptosteroid 4 | NA | chemical reagent | NA | NA | 1.0e-02 | CCL2,Ccl2 | NA |
| mercaptosteroid 6 | NA | chemical reagent | NA | NA | 1.0e-02 | CCL2,Ccl2 | NA |
| PX-12 | NA | chemical drug | NA | NA | 1.0e-02 | CD274,SAT1 | NA |
| SK & F 86002 | NA | chemical drug | NA | NA | 1.0e-02 | Acan,FCER2 | NA |
| mecamylamine | NA | chemical drug | NA | NA | 1.0e-02 | FOS,KCNJ11 | NA |
| tomelukast | NA | chemical drug | NA | NA | 1.0e-02 | CPT1B,MMP9 | 382 (11) |
| p-chloroamphetamine | NA | chemical drug | NA | NA | 1.0e-02 | FOS,SMO | NA |
| rocuronium | NA | chemical drug | NA | NA | 1.0e-02 | MMP9,PTGS2 | 266 (8) |
| natamycin | NA | chemical drug | NA | NA | 1.0e-02 | LCN2,TIMP1 | NA |
| tarenflurbil | NA | chemical drug | NA | NA | 1.0e-02 | JUNB,NGFR | 281 (7) |
| minodronate | NA | chemical drug | NA | NA | 1.0e-02 | CCL2,CXCR4 | NA |
| N-methylsulfonyl-12,12-dibromododec-11-enamide | NA | chemical reagent | NA | NA | 1.0e-02 | MMP9,S100A8 | NA |
| 10-decarbamoylmitomycin C | NA | chemical toxicant | NA | NA | 1.0e-02 | CDKN1A,GADD45A | NA |
| AZD4573 | NA | chemical drug | NA | NA | 1.0e-02 | BCL2A1,CCL2 | NA |
| Ala-Tyr-Pro-Gly-Lys-Phe-NH2 | NA | chemical reagent | NA | NA | 1.0e-02 | FOS,SELP | 380 (17) |
| glutathione diethyl ester | NA | chemical reagent | NA | NA | 1.0e-02 | GCLC,PLAUR | NA |
| senktide | NA | chemical reagent | NA | NA | 1.0e-02 | FOS,GNRH1 | 215 (9) |
| (-)-gallocatechin gallate | NA | chemical - protease inhibitor | NA | NA | 1.0e-02 | AR,IL12B | NA |
| Ad-ISF35 | NA | biologic drug | NA | NA | 1.0e-02 | CD274,IL1A | NA |
| 3,7-dimethyl-1-propargylxanthine | NA | chemical reagent | NA | NA | 1.0e-02 | F3,FOS | 216 (7) |
| citrus sinensis extract | NA | chemical drug | NA | NA | 1.0e-02 | TRPA1,TRPM6 | NA |
| stavudine | NA | chemical drug | NA | NA | 1.0e-02 | CPT1A,PPARA | NA |
| 2-amino-3-phosphonopropionic acid | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | FOS,JUNB | 233 (7) |
| epiallopregnanolone | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | LGALS3,PTGS2 | NA |
| Rar | NA | group | NA | NA | 1.0e-02 | AQP3,BTG2,CDKN1A,MGP,SFTPB,SLC10A1 | 424 (22) |
| ISGF3 | NA | complex | NA | NA | 1.0e-02 | ISG15,MX1,RSAD2,TNFSF10 | NA |
| KLF17 | NA | transcription regulator | NA | NA | 1.0e-02 | CCL24,CCL28,CDKN1A,TNFSF10 | NA |
| SHARPIN | 4.00e-02 | other | NA | NA | 1.0e-02 | CXCL10,CXCL6,IL12B,ISG15 | 264 (13) |
| LY96 | NA | transmembrane receptor | NA | NA | 1.0e-02 | CXCL2,CXCL3,IL12B,SELE | 316 (17) |
| RSL3 | NA | chemical reagent | NA | NA | 1.0e-02 | CXCR4,LCN2,LONRF1,PLA1A,WIPF3 | NA |
| ESRRB | -1.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CCL28,CDKN1A,HK2,IL12B,LOXL1,NR0B2,SLC6A6 | NA |
| PLK1 | 5.20e-01 | kinase | NA | NA | 1.0e-02 | ANKRD1,CDKN1A,EPHA2,IER3,MYC,SFN,THBS1,TNFAIP6 | NA |
| L-cysteine | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CDO1,FOS,MYC | NA |
| saikosaponin-D | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | Ccl2,FOSL1,PTGS2 | NA |
| MLT-827 | NA | chemical - protease inhibitor | NA | NA | 1.0e-02 | CXCL2,LCN2,S100A8 | NA |
| SW016789 | NA | chemical reagent | NA | NA | 1.0e-02 | ATF3,ATF4,DUSP1 | NA |
| SLC16A3 | 7.90e-01 | transporter | NA | NA | 1.0e-02 | HK2,MMP9,PFKFB3 | NA |
| AAMDC | -3.70e-01 | other | NA | NA | 1.0e-02 | ATF4,CBS/LOC102724560,MYC | NA |
| RASSF6 | -1.00e-02 | other | NA | NA | 1.0e-02 | BTG2,CDKN1A,TP73 | NA |
| berbamine | NA | chemical reagent | NA | NA | 1.0e-02 | BCL2L1,CD274,NFKBIA | NA |
| SETD1A | NA | ion channel | NA | NA | 1.0e-02 | EZH2,MYC,SOX2 | NA |
| TMEM120A | -2.30e-01 | ion channel | NA | NA | 1.0e-02 | ISG15,Mx2,RSAD2 | NA |
| MHC CLASS I (family) | NA | group | NA | NA | 1.0e-02 | ADGRE1,CD19,Mx2 | NA |
| dynasore | NA | chemical reagent | NA | NA | 1.0e-02 | KDR,PTGS2,SLC24A2 | NA |
| TIP60 | NA | complex | NA | NA | 1.0e-02 | CDKN1A,COL2A1,MYCN | NA |
| GLRX | 4.30e-01 | enzyme | NA | NA | 1.0e-02 | CXCL2,CXCL3,PDGFB | NA |
| UBA2 | 1.60e-01 | enzyme | NA | NA | 1.0e-02 | ALB,EZH2,MYC | NA |
| ZFP36L2 | 2.20e-01 | transcription regulator | NA | NA | 1.0e-02 | CD274,DDIT4,SESN2 | NA |
| mir-873 | NA | microRNA | NA | NA | 1.0e-02 | CCL2,Ccl2,CXCL3 | NA |
| miR-3118 (and other miRNAs w/seed GUGACUG) | NA | mature microRNA | NA | NA | 1.0e-02 | CREB1,LIMK1,NR5A2 | NA |
| Ccl6 | 4.40e-01 | cytokine | NA | NA | 1.0e-02 | Ccl2,CTSV,MMP9 | NA |
| SFRP2 | -6.80e-01 | transmembrane receptor | NA | NA | 1.0e-02 | MYC,ROR2,SOX2 | NA |
| baricitinib | NA | chemical drug | NA | NA | 1.0e-02 | CXCL10,DNASE1L3,STAT1 | NA |
| PRSS8 | 2.00e-02 | peptidase | NA | NA | 1.0e-02 | IL1A,MMP9,MYC | NA |
| NEK6 | 2.10e-01 | kinase | NA | NA | 1.0e-02 | CXCL10,PTGS2,RILPL1 | NA |
| COCH | NA | other | NA | NA | 1.0e-02 | Ccl2,CXCL2,SOX2 | NA |
| SCUBE3 | -2.60e-01 | other | NA | NA | 1.0e-02 | FGFR4,MMP9,SERPINE1 | NA |
| RTKN | -2.00e-01 | other | NA | NA | 1.0e-02 | BCL2A1,BCL2L1,FOS | NA |
| SMARCC2 | -6.00e-02 | transcription regulator | NA | NA | 1.0e-02 | KDR,NPC2,TBX21 | NA |
| HP | -2.60e-01 | peptidase | NA | NA | 1.0e-02 | CD163,FOS,HMOX1 | NA |
| CSNK1A1 | -4.00e-02 | kinase | NA | NA | 1.0e-02 | CDKN1A,CXCR4,MYC | NA |
| PDYN | 3.00e-02 | transporter | NA | NA | 1.0e-02 | KDR,NRP1,PLXND1 | NA |
| asbestos | NA | chemical toxicant | NA | NA | 1.0e-02 | FOSL1,JUNB,TGFA | NA |
| cilostamide | NA | chemical reagent | NA | NA | 1.0e-02 | ARG2,Ccl2,FOS | NA |
| cariporide | NA | chemical drug | NA | NA | 1.0e-02 | Eda,HK2,PPP3R1 | NA |
| atipamezole | NA | chemical drug | NA | NA | 1.0e-02 | Ccl2,FOS,JUNB | NA |
| PD 168393 | NA | chemical drug | NA | NA | 1.0e-02 | CCL2,CXCL10,RGS16 | NA |
| racemic flurbiprofen | NA | chemical drug | NA | NA | 1.0e-02 | IL24,MMP9,PTGS2 | NA |
| RP 73401 | NA | chemical toxicant | NA | NA | 1.0e-02 | BTG2,CXCL2,STAT1 | NA |
| ketorolac | NA | chemical drug | NA | NA | 1.0e-02 | Ccl2,NFKBIA,PTGS2 | NA |
| SR1078 | NA | chemical reagent | NA | NA | 1.0e-02 | ATF4,Ccl2,EDEM1 | NA |
| I-BOP | NA | chemical reagent | NA | NA | 1.0e-02 | CCL2,PTGS2,SELE | NA |
| cordycepin | NA | chemical drug | NA | NA | 1.0e-02 | ADORA1,FOS,MYC | NA |
| prolinedithiocarbamate | NA | chemical reagent | NA | NA | 1.0e-02 | CCL2,HSH2D,NFKBIA | NA |
| alpha-methylparatyrosine | NA | chemical drug | NA | NA | 1.0e-02 | ADGRE1,Ccl2,CXCL3 | NA |
| miricorilant | NA | chemical reagent | NA | NA | 1.0e-02 | APOB,FASN,FKBP5 | NA |
| Pln | -8.30e-01 | other | NA | NA | 1.0e-02 | AK1,ATP1A1,BLK,FABP3,GNAI2,KCNJ12,PRKCB,RYR2 | NA |
| Sod | NA | group | NA | NA | 1.0e-02 | Ccl2,CCL4,CXCL3,HMOX1 | NA |
| MESP2 | 1.80e-01 | transcription regulator | NA | NA | 1.0e-02 | FOXC1,LMO4,MYOCD,ZEB2 | NA |
| LBP | 1.90e-01 | transporter | NA | NA | 1.0e-02 | CD14,CXCL10,CXCL3,IFIT1 | NA |
| TOR1A | 2.80e-01 | enzyme | NA | NA | 1.0e-02 | ALB,Nrgn,PDE10A,STON2 | NA |
| IL19 | 2.00e-02 | cytokine | NA | NA | 1.0e-02 | CCL2,CXCR4,HMOX1,MMP9 | NA |
| AP20187 | NA | chemical reagent | NA | NA | 1.0e-02 | ATF4,CD14,FOS,PTGS2 | NA |
| mevastatin | NA | chemical drug | NA | NA | 1.0e-02 | ADAMTS1,AR,CDKN1A,PTGS2 | NA |
| HSP90AB1 | -2.00e-01 | enzyme | NA | NA | 1.0e-02 | ATF3,BCL2L1,CD274,KCNJ11,MYC | NA |
| CBX3 | -1.60e-01 | transcription regulator | NA | NA | 1.0e-02 | BCL2L1,CDKN1A,HSD11B2,ITGA7,MYC,PPL | NA |
| mercuric chloride | NA | chemical toxicant | NA | NA | 1.0e-02 | CDKN1A,GADD45A,GCLC,HMOX1,JUNB,Mt1 | NA |
| RAG1 | -4.00e-02 | enzyme | NA | NA | 1.0e-02 | BMP2,CD79A,COL2A1,CXCL10,CXCL2,ISG15,STAT1 | NA |
| GPD1 | -3.90e-01 | enzyme | NA | NA | 1.0e-02 | C9,CLCA1,Clec2e/Clec2h,CYP7B1,FMO3,GADD45A,GBP4,PFKFB3,PRIMA1,PSAT1,SERPINB1 | NA |
| cyclopropanecarboxylic acid | NA | chemical reagent | NA | NA | 1.0e-02 | CPT1A,CXCL10,F10,MYC,PCK1,PDHA1 | NA |
| EBF3 | -7.00e-01 | transcription regulator | NA | NA | 1.0e-02 | CCL24,CXCL3,IL12B,LTA,TNFSF8,XCL1 | NA |
| exenatide | NA | biologic drug | NA | NA | 1.0e-02 | FOS,HMOX1,MMP9,PER1,PTGS2,TXNIP | NA |
| leukotriene B4 | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | Ccl2,CXCL2,F3,FASN,MMP9 | NA |
| 4-nitroquinoline-1-oxide | NA | chemical toxicant | NA | NA | 1.0e-02 | AURKB,CD274,CDKN1A,MMP9,PTGS2 | NA |
| TRAF5 | -3.20e-01 | transporter | NA | NA | 1.0e-02 | FCER2,IL12B,SOCS3,TBX21 | NA |
| ADORA1 | 1.68e+00 | G-protein coupled receptor | NA | NA | 1.0e-02 | CCL17,CCL24,MMP9,Pln | NA |
| IRX5 | NA | transcription regulator | NA | NA | 1.0e-02 | CXCL10,IL33,TNFSF10,TNFSF8 | NA |
| isoliquiritigenin | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | CDKN1A,KDR,MMP9,PTGS2 | NA |
| magnolol | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | CDKN1A,FOS,MMP9,PTGS2 | NA |
| CAY10585 | NA | chemical reagent | NA | NA | 1.0e-02 | ADORA2B,CCL2,Ccl2 | NA |
| F630028O10Rik | NA | other | NA | NA | 1.0e-02 | Ccl2,CXCL2,PTPRC | NA |
| ANKRD17 | -6.00e-02 | other | NA | NA | 1.0e-02 | ARID5A,HDC,SOCS3 | NA |
| CLEC14A | 6.90e-01 | other | NA | NA | 1.0e-02 | CCL2,Ccl2,PLAUR | NA |
| NQO2 | -2.60e-01 | enzyme | NA | NA | 1.0e-02 | CXCR4,MMP9,PTGS2 | NA |
| Shc | NA | group | NA | NA | 1.0e-02 | BCL2L1,FOS,MYC | NA |
| FRS3 | -3.10e-01 | other | NA | NA | 1.0e-02 | CCL2,CCL4,CXCL6 | NA |
| CAVIN1 | NA | transcription regulator | NA | NA | 1.0e-02 | ADGRE1,CDKN1A,MYC | NA |
| PPM1D | 2.60e-01 | phosphatase | NA | NA | 1.0e-02 | BCL2L1,CDKN1A,GLI1 | NA |
| SRD5A2 | 1.70e-01 | enzyme | NA | NA | 1.0e-02 | CREB1,Mt1,SOAT1 | NA |
| LGALS8 | 0.00e+00 | other | NA | NA | 1.0e-02 | CCL2,CDKN1A,CXCL3 | NA |
| PKP2 | 6.00e-02 | other | NA | NA | 1.0e-02 | Ccl2,COL2A1,IL1A | NA |
| mir-541 | NA | microRNA | NA | NA | 1.0e-02 | AR,MYC,PTPRN | NA |
| AMBP | -3.60e-01 | transporter | NA | NA | 1.0e-02 | Ccl2,CXCL2,CXCL3 | NA |
| NMNAT1 | -1.70e-01 | enzyme | NA | NA | 1.0e-02 | NELL2,RAPGEF4,SOCS2 | NA |
| NCK1 | -1.00e-02 | kinase | NA | NA | 1.0e-02 | ATF4,CD69,FOS | NA |
| FRMD6 | -6.00e-02 | other | NA | NA | 1.0e-02 | BMP2,CDKN1A,PDGFB | NA |
| WZ-4002 | NA | chemical drug | NA | NA | 1.0e-02 | BCL2L1,CD274,HK2 | NA |
| DUSP6 | 2.50e-01 | phosphatase | NA | NA | 1.0e-02 | ARG2,CDKN1A,PCK1 | NA |
| SETD7 | -3.00e-02 | enzyme | NA | NA | 1.0e-02 | CXCL10,MYC,SOX2 | NA |
| GRM5 | -1.50e-01 | G-protein coupled receptor | NA | NA | 1.0e-02 | BCL2L1,FOS,THBS1 | NA |
| PLIN2 | -2.90e-01 | other | NA | NA | 1.0e-02 | Acot1,ADGRE1,PCK1 | NA |
| CFH | -7.00e-02 | other | NA | NA | 1.0e-02 | APOB,CRP,CXCL2 | NA |
| LY9 | -1.00e-01 | other | NA | NA | 1.0e-02 | CD19,CR2,ZBTB16 | NA |
| SH2B1 | -3.00e-02 | other | NA | NA | 1.0e-02 | FOSL1,MYC,PLAUR | NA |
| SLC6A1 | 4.70e-01 | transporter | NA | NA | 1.0e-02 | BCL2L1,STAT1,TBX21 | NA |
| TRPA1 | -7.20e-01 | transporter | NA | NA | 1.0e-02 | CXCL3,FOS,TRPA1 | NA |
| ATF5 | -1.10e-01 | transcription regulator | NA | NA | 1.0e-02 | PLAT,Pmaip1,TXNIP | NA |
| BRMS1 | NA | transcription regulator | NA | NA | 1.0e-02 | CXCR4,GJB1,GJB2 | NA |
| NEK2 | NA | kinase | NA | NA | 1.0e-02 | BCL2L1,CDKN1A,GADD45A | NA |
| GPAT4 | 2.00e-01 | enzyme | NA | NA | 1.0e-02 | ATF3,ATF4,ERN1 | NA |
| ZMYND8 | -1.50e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,DAB2IP,PIK3IP1 | NA |
| diltiazem | NA | chemical drug | NA | NA | 1.0e-02 | Cyp4a14,EDN1,FOS | NA |
| cortistatin A | NA | chemical reagent | NA | NA | 1.0e-02 | BHLHE40,FOSL2,GFI1 | NA |
| CBR-470-1 | NA | chemical drug | NA | NA | 1.0e-02 | GCLC,HMOX1,TXNRD1 | NA |
| acitretin | NA | chemical drug | NA | NA | 1.0e-02 | IL12B,ODC1,TGM1 | NA |
| mastoparan | NA | chemical toxicant | NA | NA | 1.0e-02 | CXCL10,IL12B,SELE | NA |
| BQ-788 | NA | biologic drug | NA | NA | 1.0e-02 | CXCL2,EDN1,MCAM | NA |
| 2-oxoglutaric acid | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CIDEA,DIO2,PNPLA2 | NA |
| oleoylethanolamide | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | BCL2L1,CPT1A,FOS | NA |
| L-N6-(1-iminoethyl)-lysine | NA | chemical reagent | NA | NA | 1.0e-02 | HMOX1,IRS1,PTGS2 | NA |
| SLR14 | NA | chemical reagent | NA | NA | 1.0e-02 | CD274,CXCL10,CXCL6 | NA |
| SLC25A13 | NA | transporter | NA | NA | 1.0e-02 | C9,CLCA1,Clec2e/Clec2h,CYP7B1,FMO3,GADD45A,GBP4,PFKFB3,PRIMA1,PSAT1,SERPINB1 | NA |
| IGHM | NA | transmembrane receptor | NA | NA | 2.0e-02 | BCL2L1,Ccl2,CD22,LGALS3,MYC,SELP | NA |
| SP4 | 0.00e+00 | transcription regulator | NA | NA | 2.0e-02 | CCL2,CCL24,CCL28,CDKN1A,CXCL3,IL2RB,TNFSF10 | NA |
| SMC1A | 4.00e-02 | transporter | NA | NA | 2.0e-02 | CSF3R,EZH2,Meis1,MYC,Nes,SOX2,TINAGL1 | NA |
| CLDN6 | 3.50e-01 | other | NA | NA | 2.0e-02 | ATF4,CLDN11,CLDN4,CLDN5,ERN1 | NA |
| sofalcone | NA | chemical drug | NA | NA | 2.0e-02 | GCLC,HMOX1 | NA |
| cloprostenol | NA | chemical drug | NA | NA | 2.0e-02 | SOCS3,TIMP1 | NA |
| Rp-8-Br-cGMPS | NA | chemical - kinase inhibitor | NA | NA | 2.0e-02 | FOS,RYR2 | NA |
| istradefylline | NA | chemical drug | NA | NA | 2.0e-02 | Ccl2,PPP1R1B | NA |
| 8-(3-chlorostyryl)caffeine | NA | chemical reagent | NA | NA | 2.0e-02 | ADORA2A,FOS | NA |
| PD 180970 | NA | chemical drug | NA | NA | 2.0e-02 | BCL2L1,MYC | NA |
| 4beta-hydroxycholesterol | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | FASN,LPIN1 | NA |
| N4 | NA | chemical reagent | NA | NA | 2.0e-02 | BCL2L1,MYC | NA |
| SKA3 | 1.40e-01 | other | NA | NA | 2.0e-02 | HK2,PFKFB3 | NA |
| GPR55 | -6.80e-01 | G-protein coupled receptor | NA | NA | 2.0e-02 | FASN,IRS1 | NA |
| colfosceril palmitate | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | CCL2,CXCL10 | NA |
| heat-not-burn cigarette smoke extract | NA | chemical toxicant | NA | NA | 2.0e-02 | Gsta1,HMOX1 | NA |
| Rsk | NA | group | NA | NA | 2.0e-02 | ATF4,CXCL2 | NA |
| 1-methyl-2-pyrrolidinone | NA | chemical drug | NA | NA | 2.0e-02 | FOS,MMP9 | NA |
| RAR ligand-RARα-Retinoic acid-RXRα | NA | complex | NA | NA | 2.0e-02 | ABCC2,SLC10A1 | NA |
| PHA-665752 | NA | chemical drug | NA | NA | 2.0e-02 | BCL2L1,PTGS2 | NA |
| NPSR1 | 4.00e-02 | G-protein coupled receptor | NA | NA | 2.0e-02 | GADD45A,MYC | NA |
| CHIA | 2.20e-01 | enzyme | NA | NA | 2.0e-02 | CCL17,CCL2 | NA |
| ZXDC | 2.70e-01 | transcription regulator | NA | NA | 2.0e-02 | CCL2,CD14 | NA |
| DNAJB4 | 2.30e-01 | other | NA | NA | 2.0e-02 | CDKN1A,STAT1 | NA |
| Carlr | NA | other | NA | NA | 2.0e-02 | IL1A,PTGS2 | NA |
| LEO1 | -2.10e-01 | other | NA | NA | 2.0e-02 | Meis1,SOX2 | NA |
| MYBPC3 | -2.80e-01 | other | NA | NA | 2.0e-02 | Ccl2,CXCL10 | NA |
| GJB6 | 1.30e-01 | transporter | NA | NA | 2.0e-02 | GJB1,GJB2 | NA |
| ZDHHC22 | -1.10e-01 | other | NA | NA | 2.0e-02 | LTA,TNFSF8 | NA |
| CYP2C8 | NA | enzyme | NA | NA | 2.0e-02 | Ccl2,SELE | NA |
| RNF43 | -2.20e-01 | enzyme | NA | NA | 2.0e-02 | F2RL1,GLUL | NA |
| NKAP | -1.90e-01 | transcription regulator | NA | NA | 2.0e-02 | ST8SIA1,ST8SIA6 | NA |
| XRN2 | 6.00e-02 | enzyme | NA | NA | 2.0e-02 | FRAT2,MYC | NA |
| ZDHHC20 | 2.60e-01 | enzyme | NA | NA | 2.0e-02 | LTA,TNFSF8 | NA |
| Sapk | NA | group | NA | NA | 2.0e-02 | FOS,GADD45A | NA |
| asparagine | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | ALB,ODC1 | NA |
| MOAP1 | 3.70e-01 | other | NA | NA | 2.0e-02 | GCLC,HMOX1 | NA |
| G0S2 | -1.41e+00 | other | NA | NA | 2.0e-02 | CDCA7,MYC | NA |
| ANXA5 | 2.00e-01 | transporter | NA | NA | 2.0e-02 | CDKN1A,F3 | NA |
| SPTBN1 | -1.80e-01 | other | NA | NA | 2.0e-02 | BCL2L1,FOS | NA |
| GRPR | 7.00e-02 | G-protein coupled receptor | NA | NA | 2.0e-02 | CDKN1A,MYCN | NA |
| miR-515-5p (and other miRNAs w/seed UCUCCAA) | NA | mature microRNA | NA | NA | 2.0e-02 | PIK3C2B,SPHK1 | NA |
| miR-516a-3p (and other miRNAs w/seed GCUUCCU) | NA | mature microRNA | NA | NA | 2.0e-02 | AR,WNT5A | NA |
| mir-340 | NA | microRNA | NA | NA | 2.0e-02 | PLAT,TGFA | NA |
| ANKH | -1.20e-01 | transporter | NA | NA | 2.0e-02 | COL2A1,WNT5A | NA |
| LIMK1 | 9.50e-01 | kinase | NA | NA | 2.0e-02 | LIMK1,MYC | NA |
| BMS 182874 | NA | chemical reagent | NA | NA | 2.0e-02 | SELE,SELP | NA |
| SLC12A3 | 1.00e-02 | transporter | NA | NA | 2.0e-02 | Ccl2,TRPM6 | NA |
| GCLC | 6.40e-01 | enzyme | NA | NA | 2.0e-02 | FOS,JUNB | NA |
| CD151 | 2.00e-01 | other | NA | NA | 2.0e-02 | CD69,MMP9 | NA |
| TPP2 | -9.00e-02 | peptidase | NA | NA | 2.0e-02 | PRF1,TBX21 | NA |
| IGL | NA | other | NA | NA | 2.0e-02 | BCL2L1,IL4R | NA |
| AHNAK | 1.00e-02 | other | NA | NA | 2.0e-02 | CDKN1A,MYC | NA |
| anatabine | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | IL1R2,PTGS2 | NA |
| ZDHHC17 | -2.60e-01 | enzyme | NA | NA | 2.0e-02 | LTA,TNFSF8 | NA |
| GIPC1 | 1.20e-01 | other | NA | NA | 2.0e-02 | SERPINE1,TGFBR3 | NA |
| RGD1560225 | NA | other | NA | NA | 2.0e-02 | EDN1,PTGS2 | NA |
| ELOA | 1.60e-01 | transcription regulator | NA | NA | 2.0e-02 | ATF3,CDKN1A | NA |
| AKAP13 | 1.00e-02 | other | NA | NA | 2.0e-02 | FKBP5,FOS | NA |
| S3I-1757 | NA | chemical reagent | NA | NA | 2.0e-02 | BCL2L1,MMP9 | NA |
| MTHFD2 | 3.70e-01 | enzyme | NA | NA | 2.0e-02 | CD274,SOX2 | NA |
| Hyaluronidase | NA | biologic drug | NA | NA | 2.0e-02 | ADAMTS4,TNFAIP6 | NA |
| COL1A2 | NA | other | NA | NA | 2.0e-02 | CDKN1A,SERPINE1 | NA |
| ERO1A | 1.30e-01 | enzyme | NA | NA | 2.0e-02 | CXCL2,CXCL3 | NA |
| ANGPTL7 | NA | other | NA | NA | 2.0e-02 | IRS1,SOCS3 | NA |
| GZMB | -1.22e+00 | peptidase | NA | NA | 2.0e-02 | CD274,KCNA3 | NA |
| USP17L22 (includes others) | NA | peptidase | NA | NA | 2.0e-02 | JUNB,MYC | NA |
| S100A11 | 3.00e-02 | other | NA | NA | 2.0e-02 | ADAMTS4,CDKN1A | NA |
| ZDHHC11 | NA | enzyme | NA | NA | 2.0e-02 | LTA,TNFSF8 | NA |
| ceralasertib | NA | chemical drug | NA | NA | 2.0e-02 | BTG2,CDKN1A | NA |
| RRM2B | -5.00e-01 | enzyme | NA | NA | 2.0e-02 | CDKN1A,Pmaip1 | NA |
| N-hydroxy-2,2-diphenylacetamide | NA | chemical reagent | NA | NA | 2.0e-02 | EDN1,IL12B | NA |
| 1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione | NA | chemical reagent | NA | NA | 2.0e-02 | CEBPD,CREB1 | NA |
| p38 MAP kinase inhibitor | NA | chemical drug | NA | NA | 2.0e-02 | CDKN1A,MMP9 | NA |
| abrocitinib | NA | chemical drug | NA | NA | 2.0e-02 | MYC,SOCS3 | NA |
| iopanoic acid | NA | chemical drug | NA | NA | 2.0e-02 | G0S2,PNPLA2 | NA |
| verlukast | NA | chemical drug | NA | NA | 2.0e-02 | CCL2,CCL4 | NA |
| diamide | NA | chemical reagent | NA | NA | 2.0e-02 | SDC4,SELE | NA |
| bumetanide | NA | chemical drug | NA | NA | 2.0e-02 | NGFR,PTGS2 | NA |
| 1,5-dihydroxyisoquinoline | NA | chemical reagent | NA | NA | 2.0e-02 | EDN1,EDNRA | NA |
| betamethasone valerate | NA | chemical drug | NA | NA | 2.0e-02 | MMP9,PTGS2 | NA |
| vanadium pentoxide | NA | chemical toxicant | NA | NA | 2.0e-02 | CXCL10,PTGS2 | NA |
| chlorophyllin | NA | chemical toxicant | NA | NA | 2.0e-02 | CCL2,HMOX1 | NA |
| 1,1-diethyl-2-hydroxy-2-nitrosohydrazine | NA | chemical toxicant | NA | NA | 2.0e-02 | GADD45A,NFKBIA | NA |
| WZB117 | NA | chemical reagent | NA | NA | 2.0e-02 | CXCL3,S100A8 | NA |
| SF2523 | NA | chemical drug | NA | NA | 2.0e-02 | MAP1LC3B,MYCN | NA |
| 6-cyclopropyl-1-(4-fluorophenyl)-3-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxylic acid | NA | chemical reagent | NA | NA | 2.0e-02 | PDK4,PEX11A | NA |
| 1-eicosapentaenoylglycerol | NA | chemical reagent | NA | NA | 2.0e-02 | MMP9,PTGS2 | NA |
| vapreotide | NA | biologic drug | NA | NA | 2.0e-02 | CCL2,THBS1 | NA |
| phosphoramidon | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | ECE1,EDN1 | NA |
| atosibanum | NA | biologic drug | NA | NA | 2.0e-02 | CDKN1A,PTGS2 | NA |
| D-Pen-2,5-enkephalin | NA | chemical reagent | NA | NA | 2.0e-02 | GZMB,PRF1 | NA |
| perillic acid | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | CD40LG,CD69 | NA |
| nigella sativa extract | NA | chemical drug | NA | NA | 2.0e-02 | TRPA1,TRPM6 | NA |
| anthemis hyalina extract | NA | chemical drug | NA | NA | 2.0e-02 | TRPA1,TRPM6 | NA |
| procysteine | NA | chemical drug | NA | NA | 2.0e-02 | CCL2,SMPD3 | NA |
| isoacteoside | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | GCLC,HMOX1 | NA |
| steroid hormone | NA | chemical - other | NA | NA | 2.0e-02 | CXCR4,GNRH1 | NA |
| EHMT2 | -8.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A,HSD11B2,MAP1LC3B,MYC,PPL,PTGS2,SYCE1,ZEB2 | NA |
| oridonin | NA | chemical drug | NA | NA | 2.0e-02 | BCL2L1,CDKN1A,CSF3R,HMOX1 | NA |
| PANX1 | 1.20e-01 | transporter | NA | NA | 2.0e-02 | Ccl2,CXCL2,HMOX1,IL1A | NA |
| TFEC | 9.00e-02 | transcription regulator | NA | NA | 2.0e-02 | BCL11A,CSF3R,GBP7,XCL1 | NA |
| FOXN1 | NA | transcription regulator | NA | NA | 2.0e-02 | CD274,GZMA,KRT81,SERPINB1 | NA |
| CDK5R1 | -1.80e-01 | kinase | NA | NA | 2.0e-02 | CD14,FOS,PPP1R1B,SERPINE1 | NA |
| Cux1 | NA | transcription regulator | NA | NA | 2.0e-02 | CD8A,CXCL10,DKK2,KRT75 | NA |
| GSE1 | 2.00e-02 | other | NA | NA | 2.0e-02 | ACOX2,FOS,ITGA7,LY86,RILPL1,SLC7A5 | NA |
| NSD2 | -2.00e-02 | enzyme | NA | NA | 2.0e-02 | BTG2,CXCR4,FOS,GADD45A,ITGB7,STAT1 | NA |
| PRKAG3 | -8.00e-02 | kinase | NA | NA | 2.0e-02 | ANKRD1,ANXA8/ANXA8L1,AQP1,ATP1B1,BTG2,FTL,GADD45G,JUNB,MAP2K6,MMD,ODC1,RGCC,TRIM16,WNK2,ZEB2,ZFP36 | NA |
| TAF6 | -2.80e-01 | transcription regulator | NA | NA | 2.0e-02 | ATF3,BCL11B,CDKN1A,GADD45A,TTC32 | NA |
| UDP | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | Ccl2,CCL4,SERPINE1 | NA |
| 2-chloro-N(6)cyclopentyladenosine | NA | chemical reagent | NA | NA | 2.0e-02 | BCL2L1,F3,SPHK1 | NA |
| azathioprine | NA | chemical drug | NA | NA | 2.0e-02 | CD27,IL21R,TNFSF10 | NA |
| L-serine | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | ATF4,CDKN1A,PSAT1 | NA |
| nitroglycerin | NA | chemical drug | NA | NA | 2.0e-02 | HMOX1,PLAUR,TP73 | NA |
| coal tar | NA | chemical drug | NA | NA | 2.0e-02 | GCLC,HMOX1,PTGS2 | NA |
| CPT1C | -8.00e-02 | enzyme | NA | NA | 2.0e-02 | CPT1A,CPT1B,PDK4 | NA |
| TM4SF5 | NA | other | NA | NA | 2.0e-02 | PRF1,SLAMF6,TNFSF10 | NA |
| PPP1R15B | 2.00e-01 | phosphatase | NA | NA | 2.0e-02 | ATF4,NUPR1,SESN2 | NA |
| Traj18 | NA | other | NA | NA | 2.0e-02 | Ccl2,CXCL2,CXCL3 | NA |
| DLG1 | -4.00e-02 | kinase | NA | NA | 2.0e-02 | IL12B,KCNA3,KCNJ12 | NA |
| ganetespib | NA | chemical drug | NA | NA | 2.0e-02 | AR,MYC,STAT1 | NA |
| TXK | -4.60e-01 | kinase | NA | NA | 2.0e-02 | IL2RB,TBX21,ZBTB16 | NA |
| IL17RD | -1.40e-01 | other | NA | NA | 2.0e-02 | Ccl2,CXCL3,Retnlg | NA |
| TTR | -4.10e-01 | transporter | NA | NA | 2.0e-02 | Ccl2,CXCL3,CXCL6 | NA |
| mir-449 | NA | microRNA | NA | NA | 2.0e-02 | AR,CCDC113,DNAH6 | NA |
| miR-208a-3p (and other miRNAs w/seed UAAGACG) | NA | mature microRNA | NA | NA | 2.0e-02 | CD14,CD40LG,PTGIR | NA |
| mir-224 | NA | microRNA | NA | NA | 2.0e-02 | CDKN1A,DIO1,MMP9 | NA |
| WNT5B | -9.00e-02 | other | NA | NA | 2.0e-02 | ATF4,COL2A1,SLC7A5 | NA |
| TNNI3 | -5.60e-01 | transporter | NA | NA | 2.0e-02 | Ccl2,CCL4,CXCL3 | NA |
| SLC9A1 | 1.00e-02 | ion channel | NA | NA | 2.0e-02 | HK2,PPP3R1,SELE | NA |
| ELK3 | -6.20e-01 | transcription regulator | NA | NA | 2.0e-02 | FOS,HMOX1,SERPINE1 | NA |
| Cxcl3 | 1.20e-01 | cytokine | NA | NA | 2.0e-02 | CCL24,CEBPD,IL33 | NA |
| BP-1-102 | NA | chemical reagent | NA | NA | 2.0e-02 | BCL2L1,NFIL3,TGFA | NA |
| J11-Cl | NA | chemical reagent | NA | NA | 2.0e-02 | CXCL2,CXCL3,PTGS2 | NA |
| sesame oil | NA | chemical reagent | NA | NA | 2.0e-02 | MMP9,PTGS2,TIMP1 | NA |
| Z-DEVD-FMK | NA | chemical - protease inhibitor | NA | NA | 2.0e-02 | CXCL2,CXCL3,SPHK1 | NA |
| zeaxanthin | NA | chemical drug | NA | NA | 2.0e-02 | HAS3,SPON2,TIMP1 | NA |
| hexamethoxyflavone | NA | chemical toxicant | NA | NA | 2.0e-02 | AR,MMP9,PTGS2 | NA |
| theophylline | NA | chemical drug | NA | NA | 2.0e-02 | FOS,LGALS12,THBS1 | NA |
| tyrphostin AG 1296 | NA | chemical drug | NA | NA | 2.0e-02 | Ccl2,CD14,PTGS2 | NA |
| allopregnanolone | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | FOS,LGALS3,PTGS2 | NA |
| methylselenic acid | NA | chemical reagent | NA | NA | 2.0e-02 | ADAMTS1,AR,ATF3,BCL2A1,BCL2L1,CDH15,CDKN1A,CREB1,DYNLL1,FKBP5,GADD45A,GPR37,JUNB,MYC,NEDD4L,NFIL3,RAPGEF4,RND3,SAT1,TGFBR3,WNT7A,ZBTB16 | NA |
| IDH1 | -2.00e-02 | enzyme | NA | NA | 2.0e-02 | ATF4,EDEM1,FASN,GLI1,MX1,PCK1,SERPINH1,ZEB2 | NA |
| MYOC | 2.00e-02 | other | NA | NA | 2.0e-02 | ADAMTS1,DDIT4,EBF3,EPHA2,KLHL41,PRKCB,SESN2,SOSTDC1,TRIM63,UPP1 | NA |
| SBDS | 4.30e-01 | other | NA | NA | 2.0e-02 | CRYM,ERBB3,FOS,GADD45B,IL4R,MAFF,MAOA,PCDHB2,PTPRO,XCL1 | NA |
| SOX14 | 2.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CCL2,CXCL10,TNFSF10,TNFSF8 | NA |
| TNFRSF13C | -9.80e-01 | transmembrane receptor | NA | NA | 2.0e-02 | BCL2A1,BCL2L1,CD40LG,CR2 | NA |
| Klra7 (includes others) | NA | transmembrane receptor | NA | NA | 2.0e-02 | CCL4,Mt1,TBX21,XCL1 | NA |
| ZFHX3 | -3.00e-02 | transcription regulator | NA | NA | 2.0e-02 | ALB,Elf5,F2RL1,LRRC17,Nes,NGFR,PTGER3,RGS16,TRH,VIPR2 | NA |
| beraprost | NA | chemical drug | NA | NA | 2.0e-02 | CCL2,CREM,EDN1 | NA |
| ulipristal acetate | NA | chemical drug | NA | NA | 2.0e-02 | AR,BCL2L1,KDR | NA |
| naringin | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | CCL2,HMOX1,MMP9 | NA |
| tectorigenin | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | ATF4,BCL2L1,LPAR1 | NA |
| Il8r | NA | group | NA | NA | 2.0e-02 | BCL2L1,CR2,MMP9 | NA |
| MELK | -9.00e-02 | kinase | NA | NA | 2.0e-02 | CDKN1A,MYC,SOX2 | NA |
| USP28 | 2.00e-02 | peptidase | NA | NA | 2.0e-02 | CD274,CDKN1A,MYC | NA |
| FOXK2 | NA | transcription regulator | NA | NA | 2.0e-02 | ERN1,SERPINE1,SOX2 | NA |
| MTORC2 | NA | complex | NA | NA | 2.0e-02 | CCL2,FASN,ISG15 | NA |
| ALOX12 | -3.40e-01 | enzyme | NA | NA | 2.0e-02 | CXCL3,FOSL1,IL12B | NA |
| 4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid | NA | chemical reagent | NA | NA | 2.0e-02 | Ccl2,FOS,HMOX1 | NA |
| CHRM3 | -9.00e-02 | G-protein coupled receptor | NA | NA | 2.0e-02 | FOS,HMOX1,MMP9 | NA |
| miR-451a (and other miRNAs w/seed AACCGUU) | NA | mature microRNA | NA | NA | 2.0e-02 | ABCB1,ADAMTS5,MMP9 | NA |
| miR-330-5p (and other miRNAs w/seed CUCUGGG) | NA | mature microRNA | NA | NA | 2.0e-02 | BCL2L1,SMO,TGFBR3 | NA |
| PRAME | NA | other | NA | NA | 2.0e-02 | BCL2L1,CDKN1A,CYP26B1 | NA |
| PDE3B | -3.00e-02 | enzyme | NA | NA | 2.0e-02 | FASN,SERPINE1,SOCS3 | NA |
| APOH | -5.10e-01 | transporter | NA | NA | 2.0e-02 | CD83,F3,SELE | NA |
| DDB2 | 5.00e-02 | other | NA | NA | 2.0e-02 | CDKN1A,MMP9,NFKBIA | NA |
| FYB1 | NA | other | NA | NA | 2.0e-02 | BCL2L1,CD69,IL12B | NA |
| NUMBL | 1.70e-01 | other | NA | NA | 2.0e-02 | CDKN1A,MMP9,MYC | NA |
| RNF216 | 1.50e-01 | enzyme | NA | NA | 2.0e-02 | CXCL10,IFIT1,ISG15 | NA |
| PAX4 | 2.00e-02 | transcription regulator | NA | NA | 2.0e-02 | BCL2L1,MYC,Nes | NA |
| MSI1 | -2.80e-01 | other | NA | NA | 2.0e-02 | CDKN1A,MMP9,TIMP3 | NA |
| ITGA3 | 2.80e-01 | other | NA | NA | 2.0e-02 | CTSV,PTGS2,SERPINE1 | NA |
| GRB10 | 9.00e-02 | other | NA | NA | 2.0e-02 | FOS,IRS1,KDR | NA |
| HLF | 1.10e-01 | transcription regulator | NA | NA | 2.0e-02 | F9,PER1,PPARA | NA |
| WRN | -4.80e-01 | enzyme | NA | NA | 2.0e-02 | CDKN1A,CXCL2,IL1A | NA |
| DGKA | -1.80e-01 | kinase | NA | NA | 2.0e-02 | CCL2,CD69,CXCL2 | NA |
| NDP | NA | growth factor | NA | NA | 2.0e-02 | LIF,Mt1,NUPR1 | NA |
| fatostatin | NA | chemical reagent | NA | NA | 2.0e-02 | CCL2,Ccl2,CTSV | NA |
| brusatol | NA | chemical reagent | NA | NA | 2.0e-02 | CCL2,CXCL10,SERPINE1 | NA |
| pentylenetetrazol | NA | chemical drug | NA | NA | 2.0e-02 | FOS,SLC6A2,TIMP1 | NA |
| SR 144528 | NA | chemical reagent | NA | NA | 2.0e-02 | CCL2,CCL4,NFKBIA | NA |
| orlistat | NA | chemical drug | NA | NA | 2.0e-02 | APOB,ATF4,CCL2 | NA |
| putrescine | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | CCL2,CDKN1A,FOS | NA |
| dehydrocostus lactone | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | MMP9,MYC,PRKCB | NA |
| cucurbitacin B | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | BCL2L1,CDKN1A,MYC | NA |
| midostaurin | NA | chemical drug | NA | NA | 2.0e-02 | CCL2,HMOX1,PTGS2 | NA |
| SB204990 | NA | chemical reagent | NA | NA | 2.0e-02 | HK2,IRF4,MYC | NA |
| androstenediol | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | AR,CDKN1A,FKBP5 | NA |
| Fe2+ | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | BMP6,GCLC,HMOX1 | NA |
| Nuclear factor 1 | NA | group | NA | NA | 2.0e-02 | AR,CIITA,HSD11B2,LOX,TNFSF18 | NA |
| EIF2B5 | -1.00e-02 | translation regulator | NA | NA | 2.0e-02 | ATF4,DUSP1,HSPA12A,MYC,P4HA1 | NA |
| Hmgn3 | NA | other | NA | NA | 2.0e-02 | ABL1,AZGP1,FGA,KCNJ11,SERPINH1 | NA |
| fluvoxamine | NA | chemical drug | NA | NA | 2.0e-02 | ACKR4,CD37,FOS,GNAI2,TFPI2 | NA |
| Srebp | NA | group | NA | NA | 2.0e-02 | CDKN1A,FASN,FOS,GZMB | NA |
| SEL1L | 2.00e-02 | other | NA | NA | 2.0e-02 | EDEM1,Nes,SOX2,TIMP1 | NA |
| mitoxantrone | NA | chemical drug | NA | NA | 2.0e-02 | CDKN1A,CXCL10,Mx2,OAS2,PTGS2,RSAD2 | NA |
| GSTP1 | 1.80e-01 | enzyme | NA | NA | 3.0e-02 | B3GNT5,CBS/LOC102724560,Cyp3a25 (includes others),FKBP5,GABRP,HMOX1,IL22RA2,KCNK2,LIN7A,LYVE1,PER1,Pln,PON1,SERPINE1,SIGLEC8,SLC23A1 | NA |
| estradiol 17beta-cypionate | NA | chemical drug | NA | NA | 3.0e-02 | GNRH1,PER1 | NA |
| fludrocortisone | NA | chemical drug | NA | NA | 3.0e-02 | CXCR4,SELL | NA |
| Adenosine Receptor | NA | group | NA | NA | 3.0e-02 | CLDN5,PFKFB3 | NA |
| chondroitin sulfate E | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | MRGPRF,Tnfsf9 | NA |
| ADRA1 | NA | group | NA | NA | 3.0e-02 | FOS,JUNB | NA |
| Stat dimer | NA | complex | NA | NA | 3.0e-02 | BCL2L1,FOS | NA |
| aurapten | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | CPT1A,PTGS2 | NA |
| beta-sitosterol | NA | chemical reagent | NA | NA | 3.0e-02 | PTGS2,SELE | NA |
| cefditoren | NA | chemical drug | NA | NA | 3.0e-02 | ABCC2,SLC22A7 | NA |
| SLC22A2 | -5.50e-01 | transporter | NA | NA | 3.0e-02 | CPT1A,CPT1B | NA |
| MLYCD | 1.00e-01 | enzyme | NA | NA | 3.0e-02 | CPT1B,PDK4 | NA |
| SSBP2 | -2.00e-02 | transcription regulator | NA | NA | 3.0e-02 | EPB42,MYC | NA |
| SPINDOC | NA | other | NA | NA | 3.0e-02 | C1QTNF1,IFI44L | NA |
| ZNF524 | -1.90e-01 | other | NA | NA | 3.0e-02 | IL33,LTA | NA |
| CUZD1 | 2.00e-02 | other | NA | NA | 3.0e-02 | EPGN,EREG | NA |
| YIPF6 | 0.00e+00 | other | NA | NA | 3.0e-02 | DIO2,PNPLA2 | NA |
| DRD1/5 | NA | group | NA | NA | 3.0e-02 | FOS,NAT8L | NA |
| MCOLN2 | -2.90e-01 | ion channel | NA | NA | 3.0e-02 | Ccl2,CXCL3 | NA |
| ZNF598 | 5.20e-01 | enzyme | NA | NA | 3.0e-02 | IFI44,RSAD2 | NA |
| RSF1 | 5.00e-02 | transcription regulator | NA | NA | 3.0e-02 | BCL2L1,PTGS2 | NA |
| RPE65 | -1.10e-01 | enzyme | NA | NA | 3.0e-02 | FOS,OPN4 | NA |
| 1-16:0 lysophosphatidylcholine | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | CCL2,CXCL10 | NA |
| ALDH3A2 | 3.50e-01 | enzyme | NA | NA | 3.0e-02 | GCLC,HMOX1 | NA |
| 7S NGF | NA | complex | NA | NA | 3.0e-02 | FOS,GCLC | NA |
| Mucin | NA | group | NA | NA | 3.0e-02 | CD83,PTGS2 | NA |
| AZD1480 | NA | chemical drug | NA | NA | 3.0e-02 | CBLB,SLC7A5 | NA |
| GRAP2 | -1.40e-01 | other | NA | NA | 3.0e-02 | CD69,MYC | NA |
| IL31RA | 3.80e-01 | transmembrane receptor | NA | NA | 3.0e-02 | SOCS2,SOCS3 | NA |
| CHKA | 4.90e-01 | kinase | NA | NA | 3.0e-02 | CD274,PTGS2 | NA |
| UBB | NA | enzyme | NA | NA | 3.0e-02 | CCL2,NFKBIA | NA |
| toosendanin | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | IFIT1,MX1 | NA |
| TYMS | -3.80e-01 | enzyme | NA | NA | 3.0e-02 | CDKN1A,MYC | NA |
| RNF34 | -1.70e-01 | enzyme | NA | NA | 3.0e-02 | BCL2L1,CDKN1A | NA |
| PRODH | 3.00e-01 | enzyme | NA | NA | 3.0e-02 | PTGS2,TNFSF10 | NA |
| miR-570-3p (miRNAs w/seed GAAAACA) | NA | mature microRNA | NA | NA | 3.0e-02 | CDKN1A,MMP9 | NA |
| miR-379-5p (and other miRNAs w/seed GGUAGAC) | NA | mature microRNA | NA | NA | 3.0e-02 | BMP2,BMP6 | NA |
| mir-342 | NA | microRNA | NA | NA | 3.0e-02 | HK2,PTPRN | NA |
| mir-383 | NA | microRNA | NA | NA | 3.0e-02 | GADD45G,MYC | NA |
| CALCR | 0.00e+00 | G-protein coupled receptor | NA | NA | 3.0e-02 | CDKN1A,FOS | NA |
| ELAVL4 | -1.30e-01 | translation regulator | NA | NA | 3.0e-02 | MYCN,NRN1 | NA |
| ICAM5 | -7.10e-01 | other | NA | NA | 3.0e-02 | CD40LG,CD69 | NA |
| CXADR | -2.30e-01 | transmembrane receptor | NA | NA | 3.0e-02 | CXCL10,CXCL3 | NA |
| KIDINS220 | -1.20e-01 | transcription regulator | NA | NA | 3.0e-02 | CD69,FOS | NA |
| LAMP1 | 1.30e-01 | other | NA | NA | 3.0e-02 | PRF1,TBX21 | NA |
| NME2 | 1.00e-01 | kinase | NA | NA | 3.0e-02 | MYC,PTGS2 | NA |
| SOS1 | 2.00e-02 | other | NA | NA | 3.0e-02 | CD69,SELL | NA |
| CCL22 | -2.20e-01 | cytokine | NA | NA | 3.0e-02 | CXCL2,CXCL3 | NA |
| GJB1 | -7.20e-01 | transporter | NA | NA | 3.0e-02 | GJB1,GJB2 | NA |
| SH2B2 | -5.00e-01 | other | NA | NA | 3.0e-02 | FOS,MYC | NA |
| ANKRD1 | -7.10e-01 | transcription regulator | NA | NA | 3.0e-02 | BCL2L1,RYR2 | NA |
| EXO1 | -1.00e-01 | enzyme | NA | NA | 3.0e-02 | IFI44,ISG15 | NA |
| F9 | -6.20e-01 | peptidase | NA | NA | 3.0e-02 | F9,MMP9 | NA |
| beta-elemene | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | BCL2L1,ZEB2 | NA |
| SPRY4 | 9.00e-02 | other | NA | NA | 3.0e-02 | ISG15,MYOCD | NA |
| GNL2 | 3.60e-01 | enzyme | NA | NA | 3.0e-02 | CDKN1A,MYC | NA |
| TG6-10-1 | NA | chemical reagent | NA | NA | 3.0e-02 | ALB,Ccl2 | NA |
| Nrg1 | NA | growth factor | NA | NA | 3.0e-02 | BCL2L1,FOS | NA |
| GCLM | -1.30e-01 | enzyme | NA | NA | 3.0e-02 | FOS,JUNB | NA |
| scoparone | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | MYC,SOCS3 | NA |
| H3B-8800 | NA | chemical drug | NA | NA | 3.0e-02 | CXCL10,MX1 | NA |
| N-hydroxy-N’-(4-butyl-2-methylphenyl)formamidine | NA | chemical reagent | NA | NA | 3.0e-02 | MMP9,S100A8 | NA |
| atrasentan | NA | chemical drug | NA | NA | 3.0e-02 | BCL2L1,PTGS2 | NA |
| cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate | NA | chemical reagent | NA | NA | 3.0e-02 | ARG2,Ccl2 | NA |
| lansoprazole | NA | chemical drug | NA | NA | 3.0e-02 | CD14,PTGS2 | NA |
| triiodothyronine, reverse | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | DIO2,TRH | NA |
| tranexamic acid | NA | chemical drug | NA | NA | 3.0e-02 | F3,IL1A | NA |
| oxytetracycline | NA | chemical drug | NA | NA | 3.0e-02 | BMP2,BMP6 | NA |
| alizarin | NA | chemical toxicant | NA | NA | 3.0e-02 | BCL2L1,MYC | NA |
| ethyl protocatechuate | NA | chemical reagent | NA | NA | 3.0e-02 | BCL2L1,CDKN1A | NA |
| phloretin | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | HMOX1,TXNIP | NA |
| vanadyl sulfate | NA | chemical reagent | NA | NA | 3.0e-02 | GCLC,IL1R2 | NA |
| potassium perchlorate | NA | chemical reagent | NA | NA | 3.0e-02 | DIO1,TRH | NA |
| CBFB-MYH11 | NA | fusion gene/product | NA | NA | 3.0e-02 | ATF3,SPHK1 | NA |
| AL162253.2 | NA | other | NA | NA | 3.0e-02 | CD274,STAT1 | NA |
| 1-docosapentaenoylglycerol | NA | chemical reagent | NA | NA | 3.0e-02 | MMP9,PTGS2 | NA |
| aclarubicin | NA | chemical drug | NA | NA | 3.0e-02 | BCL2L1,PTGS2 | NA |
| 9-hydroxyoctadecadienoic acid | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | IL12B,SFTPB | NA |
| decanoic acid | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | CPT1B,PCK1 | NA |
| NADPH | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | PTGS2,TP73 | NA |
| vidarabine | NA | chemical drug | NA | NA | 3.0e-02 | BMP2,FABP3 | NA |
| 5-hydroxytryptophan | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | FOS,PTGS2 | NA |
| EED | 8.00e-02 | transcription regulator | NA | NA | 3.0e-02 | BBOX1,DAB2IP,MYC,PPP2R2B,PTGS2,SCIN | NA |
| HAND2 | -2.20e-01 | transcription regulator | NA | NA | 3.0e-02 | ACTC1,CCL2,CCL4,CXCL2,CXCL6,CXCR4,PDLIM3,PTGS2 | NA |
| POLR2A | 4.00e-02 | enzyme | NA | NA | 3.0e-02 | BCL2L1,CDKN1A,CXCR4,FOS,MYC,NFKBIA,SELE,TP73 | NA |
| BMI1 | NA | transcription regulator | NA | NA | 3.0e-02 | BTG2,CDKN1A,HK2,ID4,LOX,NGFR,P4HA1,SFN | NA |
| lactosylceramide | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | Ccl2,CIITA,CXCL10,IL12B | NA |
| MAP3K5 | 5.20e-01 | kinase | NA | NA | 3.0e-02 | Ccl2,CDKN1A,HMOX1,TGM1 | NA |
| ADRB1 | -3.80e-01 | G-protein coupled receptor | NA | NA | 3.0e-02 | ACTC1,DIO2,RYR2,THBS1 | NA |
| HMGA2 | NA | enzyme | NA | NA | 3.0e-02 | BCL2A1,CXCR4,KLF15,SOX2 | NA |
| 2-mercaptoacetate | NA | chemical drug | NA | NA | 3.0e-02 | CXCL2,CXCL3,IL12B,TREML2 | NA |
| azithromycin | NA | chemical drug | NA | NA | 3.0e-02 | Ccl2,CXCL3,MMP9 | NA |
| meldonium | NA | chemical drug | NA | NA | 3.0e-02 | CPT1A,CPT1B,SOX2 | NA |
| CXCL6 | 1.48e+00 | cytokine | NA | NA | 3.0e-02 | CCL24,IL33,MMP9 | NA |
| Mmp | NA | group | NA | NA | 3.0e-02 | CLDN5,MMP9,PLG | NA |
| IL1F10 | NA | cytokine | NA | NA | 3.0e-02 | IL1A,MERTK,PTGS2 | NA |
| BPIFA1 | -2.40e-01 | other | NA | NA | 3.0e-02 | CXCL2,CXCL3,MUC5B | NA |
| TMEM165 | 1.60e-01 | other | NA | NA | 3.0e-02 | Acan,COL2A1,SERPINE1 | NA |
| PRR11 | -3.00e-02 | other | NA | NA | 3.0e-02 | CCNA1,CDKN1A,MMP9 | NA |
| LECT2 | -1.90e-01 | other | NA | NA | 3.0e-02 | Ccl2,CXCL10,CXCL3 | NA |
| double-stranded DNA | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | CXCL10,ISG15,SOCS3 | NA |
| SAR1A | NA | enzyme | NA | NA | 3.0e-02 | CPT1A,FASN,PPARA | NA |
| IgG2a | NA | complex | NA | NA | 3.0e-02 | BCL2L1,HMOX1,LTA | NA |
| FANCA | 3.20e-01 | other | NA | NA | 3.0e-02 | CDKN1A,FANCG,WNT5A | NA |
| LRAT | -2.00e-01 | enzyme | NA | NA | 3.0e-02 | CDKN1A,PDK4,TGFA | NA |
| miR-101-3p (and other miRNAs w/seed ACAGUAC) | NA | mature microRNA | NA | NA | 3.0e-02 | EZH2,MYCN,PTGS2 | NA |
| HIF3A | 1.04e+00 | transcription regulator | NA | NA | 3.0e-02 | EDN1,PLAUR,SOX2 | NA |
| ADAR | -2.60e-01 | enzyme | NA | NA | 3.0e-02 | FOS,IFI44,ISG15 | NA |
| MSLN | 5.10e-01 | other | NA | NA | 3.0e-02 | CCL19,LTB,MMP9 | NA |
| CRY2 | 6.50e-01 | enzyme | NA | NA | 3.0e-02 | FOS,PCK1,PER1 | NA |
| FABP2 | 0.00e+00 | transporter | NA | NA | 3.0e-02 | CPT1A,FASN,PPARA | NA |
| PIK3R2 | -3.00e-02 | kinase | NA | NA | 3.0e-02 | BCL2L1,CXCL10,ISG15 | NA |
| PDE4B | 4.00e-01 | enzyme | NA | NA | 3.0e-02 | CXCL10,DUSP1,SOX2 | NA |
| DOCK2 | -3.30e-01 | other | NA | NA | 3.0e-02 | Ccl2,CIDEA,PPARA | NA |
| USP2 | 3.20e-01 | peptidase | NA | NA | 3.0e-02 | CDKN1A,SERPINC1,SERPINE1 | NA |
| PRDX1 | -1.00e-02 | enzyme | NA | NA | 3.0e-02 | IL12B,PTGS2,SELP | NA |
| USP4 | 4.00e-02 | peptidase | NA | NA | 3.0e-02 | ADORA2A,CXCR4,Nes | NA |
| B4GALNT1 | -2.70e-01 | enzyme | NA | NA | 3.0e-02 | C3AR1,FOS,IL1A | NA |
| CD163 | 6.70e-01 | transmembrane receptor | NA | NA | 3.0e-02 | Ccl2,HMOX1,MMP9 | NA |
| GATA5 | -7.80e-01 | transcription regulator | NA | NA | 3.0e-02 | ACTC1,EDN1,SLC5A1 | NA |
| AK1 | -7.10e-01 | kinase | NA | NA | 3.0e-02 | AK1,CKMT1A/CKMT1B,ENO3 | NA |
| CRLF2 | 2.20e-01 | transmembrane receptor | NA | NA | 3.0e-02 | CCL17,CLCA1,IL12B | NA |
| PKHD1 | NA | other | NA | NA | 3.0e-02 | CXCL10,CXCL2,SOCS3 | NA |
| ATXN3 | -1.60e-01 | peptidase | NA | NA | 3.0e-02 | CREB1,IFIT1,ISG15 | NA |
| KRIT1 | 1.30e-01 | other | NA | NA | 3.0e-02 | BMP2,CXCR4,THBS1 | NA |
| LETMD1 | -2.60e-01 | other | NA | NA | 3.0e-02 | CCL2,CDKN1A,PTGS2 | NA |
| CRY1 | 5.60e-01 | enzyme | NA | NA | 3.0e-02 | FOS,PCK1,PER1 | NA |
| PPP5C | 4.20e-01 | phosphatase | NA | NA | 3.0e-02 | CDKN1A,DUSP1,MYC | NA |
| 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea | NA | chemical reagent | NA | NA | 3.0e-02 | IL12B,IL33,TBX21 | NA |
| OPRM1 | 4.00e-02 | G-protein coupled receptor | NA | NA | 3.0e-02 | GZMB,MMP9,PRF1 | NA |
| PA2G4 | 1.90e-01 | transcription regulator | NA | NA | 3.0e-02 | AGR2,AR,SLC43A1 | NA |
| HSPA1A/HSPA1B | -2.90e-01 | enzyme | NA | NA | 3.0e-02 | CDKN1A,CXCL2,FOS | NA |
| CCL3L3 | -2.50e-01 | cytokine | NA | NA | 3.0e-02 | Ccl2,CCL4,CXCL10 | NA |
| 6-aminopyrazolopyrimidine derivative compound II | NA | chemical drug | NA | NA | 3.0e-02 | IL1A,ISG15,Oasl2 | NA |
| meloxicam | NA | chemical drug | NA | NA | 3.0e-02 | ABCB1,CDKN1A,PTGS2 | NA |
| abscisic acid | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | CCL17,CCL2,Ccl2 | NA |
| oxonic acid | NA | chemical drug | NA | NA | 3.0e-02 | Ccl2,CCNA1,POR | NA |
| Complement | NA | complex | NA | NA | 3.0e-02 | F3,PDGFB,SELP | NA |
| spermine nitric oxide complex | NA | chemical toxicant | NA | NA | 3.0e-02 | BCL2L1,HMOX1,SELE | NA |
| ryanodine | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | CREB1,FOS,RYR2 | NA |
| cyclomaltodextrin | NA | chemical drug | NA | NA | 3.0e-02 | CXCL3,MMP8,S100A8 | NA |
| clofibric acid | NA | chemical drug | NA | NA | 3.0e-02 | Cyp4a14,PPARA,SERPINE1 | NA |
| PCSK9 | -3.80e-01 | peptidase | NA | NA | 3.0e-02 | Ccl2,CDKN1A,ISG15,MGP,PNPLA3 | NA |
| CNOT7 | 1.00e-01 | transcription regulator | NA | NA | 3.0e-02 | CMPK2,IFI44L,ISG15,OAS2,STAT1 | NA |
| vitamin A | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | AQP1,BMP2,CDKN1A,CYP26B1,KCNG1 | NA |
| CDH2 | -1.30e-01 | other | NA | NA | 3.0e-02 | AR,CDKN1A,KCNA5,MMP9 | NA |
| LTB | -6.50e-01 | cytokine | NA | NA | 3.0e-02 | CCL19,Ccl2,CRP,SELL | NA |
| SMARCD3 | -1.80e-01 | transcription regulator | NA | NA | 3.0e-02 | COL2A1,MGP,SOX2,WNT5A | NA |
| KIF3A | -3.20e-01 | enzyme | NA | NA | 3.0e-02 | CDKN1A,COL2A1,GLI1,MYC | NA |
| LCP2 | -4.60e-01 | other | NA | NA | 3.0e-02 | CD69,NRP1,SELP,ZBTB16 | NA |
| P2RX7 | NA | ion channel | NA | NA | 3.0e-02 | CCL2,CXCL10,IL1A,TNFSF10 | NA |
| TBXT | NA | transcription regulator | NA | NA | 4.0e-02 | COL2A1,DUSP8,KDR,MGP,XCL1 | NA |
| ginsenoside Rb1 | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | FASN,FOS,PPARA | NA |
| exisulind | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CDKN1A,IL24,SAT1 | NA |
| 4-nonylphenol | NA | chemical toxicant | NA | NA | 4.0e-02 | AR,FOS,MYC | NA |
| TGFBR | NA | group | NA | NA | 4.0e-02 | ADAMTS1,SOCS3,WNT5A | NA |
| UCA1 | NA | other | NA | NA | 4.0e-02 | ABCB1,EZH2,SLC7A5 | NA |
| IFNA17 | NA | cytokine | NA | NA | 4.0e-02 | CXCL10,MX1,ZBP1 | NA |
| SAMHD1 | -1.20e-01 | enzyme | NA | NA | 4.0e-02 | MX1,NFKBIA,STAT1 | NA |
| fedratinib | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L1,CCL17,Ccl2 | NA |
| withaferin A | NA | chemical reagent | NA | NA | 4.0e-02 | CDKN1A,PTGS2,SERPINE1 | NA |
| LOXL1 | -6.50e-01 | enzyme | NA | NA | 4.0e-02 | Ccl2,MMP9,TIMP1 | NA |
| PECAM1 | NA | other | NA | NA | 4.0e-02 | BCL2L1,SELP,THBS1 | NA |
| PSMB10 | 2.00e-02 | peptidase | NA | NA | 4.0e-02 | IL1A,NFKBIA,TBX21 | NA |
| APOA4 | -4.00e-01 | transporter | NA | NA | 4.0e-02 | APOB,FOS,SELP | NA |
| VASP | 1.00e-02 | other | NA | NA | 4.0e-02 | MYC,SELP,STAT1 | NA |
| MYOF | 0.00e+00 | other | NA | NA | 4.0e-02 | Ccl2,KDR,PPARA | NA |
| miR-150-5p (and other miRNAs w/seed CUCCCAA) | NA | mature microRNA | NA | NA | 4.0e-02 | CLDN5,EDN1,PDGFB | NA |
| F10 | -7.80e-01 | peptidase | NA | NA | 4.0e-02 | CCL2,F3,SELE | NA |
| LINC-ROR | NA | other | NA | NA | 4.0e-02 | CDKN1A,SOX2,TESC | NA |
| NLRC4 | -4.70e-01 | other | NA | NA | 4.0e-02 | CXCL2,CXCL3,CXCL6 | NA |
| VLDLR | -3.40e-01 | transporter | NA | NA | 4.0e-02 | APOB,FOS,SERPINE1 | NA |
| COL6A1 | 2.90e-01 | other | NA | NA | 4.0e-02 | AK1,ENO3,FASN | NA |
| PEMT | -8.80e-01 | enzyme | NA | NA | 4.0e-02 | ADGRE1,PEMT,TIMP1 | NA |
| RALA | -1.30e-01 | enzyme | NA | NA | 4.0e-02 | CDKN1A,MMP9,PLAUR | NA |
| WNT3 | 5.00e-02 | other | NA | NA | 4.0e-02 | CDKN1A,GLI1,PTGS2 | NA |
| clasto-lactacystin beta-lactone | NA | chemical - protease inhibitor | NA | NA | 4.0e-02 | ATF3,ATF4,TP53BP2 | NA |
| trans-stilbene oxide | NA | chemical reagent | NA | NA | 4.0e-02 | ABCC2,Gsta1,HMOX1 | NA |
| dehydroxymethylepoxyquinomicin | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1,CCL2,MMP9 | NA |
| picryl chloride | NA | chemical toxicant | NA | NA | 4.0e-02 | CXCL10,CXCL3,IL1A | NA |
| JTE-013 | NA | chemical reagent | NA | NA | 4.0e-02 | CCL2,F3,SELE | NA |
| metoprolol | NA | chemical drug | NA | NA | 4.0e-02 | AQP1,EDN1,MYC | NA |
| salmeterol | NA | chemical drug | NA | NA | 4.0e-02 | DDIT4,DUSP1,SOCS3 | NA |
| muromonab-CD3 | NA | biologic drug | NA | NA | 4.0e-02 | CD69,GZMB,TBX21 | NA |
| gallic acid | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | MMP9,PLAT,SELP | NA |
| noscapine | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L1,MMP9,PTGS2 | NA |
| beta-1,3-glucan | NA | chemical drug | NA | NA | 4.0e-02 | IL12B,PDGFB,TGFA | NA |
| auranofin | NA | chemical drug | NA | NA | 4.0e-02 | GCLC,HMOX1,PTGS2 | NA |
| CYD0618 | NA | chemical reagent | NA | NA | 4.0e-02 | MMP9,MYC | NA |
| 8-hydroxyguanine | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CXCL2,IL1A | NA |
| origanum majorana extract | NA | chemical reagent | NA | NA | 4.0e-02 | MMP9,PLAUR | NA |
| GPIIB-IIIA | NA | complex | NA | NA | 4.0e-02 | MMP9,PLAUR | NA |
| 1-palmitoyl-2-oleoylphosphatidyl-D-serine | NA | chemical reagent | NA | NA | 4.0e-02 | CXCL2,CXCL3 | NA |
| phytic acid | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | BCL2L1,MMP9 | NA |
| Iberiotoxin | NA | chemical reagent | NA | NA | 4.0e-02 | CCL2,SELE | NA |
| CDC14B | -3.90e-01 | phosphatase | NA | NA | 4.0e-02 | CLDN11,Nes | NA |
| hesperidin | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L1,HMOX1 | NA |
| Dynamin | NA | group | NA | NA | 4.0e-02 | FOS,KDR | NA |
| vanillyl-N-nonylamide | NA | chemical drug | NA | NA | 4.0e-02 | ATF3,GADD45A | NA |
| lupeol | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L1,PTGS2 | NA |
| obatoclax | NA | chemical drug | NA | NA | 4.0e-02 | ATF3,ATF4 | NA |
| 5R-hydroxytriptolide | NA | chemical drug | NA | NA | 4.0e-02 | CD14,STAT1 | NA |
| N-hexanoylhomoserine lactone | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | CXCL6,IL1A | NA |
| SLC5A1 | -1.22e+00 | transporter | NA | NA | 4.0e-02 | Ccl2,SLC5A1 | NA |
| CCAR1 | -3.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CEBPD,SPHK1 | NA |
| ZMIZ1 | 1.80e-01 | transcription regulator | NA | NA | 4.0e-02 | MYC,SERPINE1 | NA |
| KCNK2 | 7.30e-01 | ion channel | NA | NA | 4.0e-02 | CCL2,KCNK2 | NA |
| CMTM7 | -1.10e-01 | cytokine | NA | NA | 4.0e-02 | IRF4,PAX5 | NA |
| USP48 | NA | peptidase | NA | NA | 4.0e-02 | GLI1,MYCN | NA |
| FKBP8 | 8.00e-02 | other | NA | NA | 4.0e-02 | GLI1,MMP9 | NA |
| AQP11 | 3.00e-02 | transporter | NA | NA | 4.0e-02 | MYC,TIMP1 | NA |
| GPR37L1 | -1.70e-01 | G-protein coupled receptor | NA | NA | 4.0e-02 | MYCN,SMO | NA |
| ACOT13 | -5.30e-01 | enzyme | NA | NA | 4.0e-02 | PCTP,PPARA | NA |
| ZMYND10 | -4.40e-01 | other | NA | NA | 4.0e-02 | MMP9,THBS1 | NA |
| EN2 | 0.00e+00 | transcription regulator | NA | NA | 4.0e-02 | NGFR,PAX5 | NA |
| ZNF395 | -1.00e-01 | transcription regulator | NA | NA | 4.0e-02 | IFI44,IFIT1 | NA |
| GPR68 | -4.00e-01 | G-protein coupled receptor | NA | NA | 4.0e-02 | DUSP1,PTGS2 | NA |
| RO4929097 | NA | chemical drug | NA | NA | 4.0e-02 | HEYL,KDR | NA |
| GSK690693 | NA | chemical drug | NA | NA | 4.0e-02 | EPHA2,ERBB3 | NA |
| RAB7 | NA | group | NA | NA | 4.0e-02 | CXCL10,MYC | NA |
| SAMD4A | 4.40e-01 | translation regulator | NA | NA | 4.0e-02 | CIDEA,PPARA | NA |
| 2-chlorohexadecanoic acid | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CPT1A,SELP | NA |
| PROKR2 | -1.90e-01 | G-protein coupled receptor | NA | NA | 4.0e-02 | GNRH1,INHBA | NA |
| NEFL | -1.90e-01 | other | NA | NA | 4.0e-02 | CCL2,Ccl2 | NA |
| TFPI | -3.80e-01 | other | NA | NA | 4.0e-02 | CDKN1A,F3 | NA |
| CD27 | -7.30e-01 | transmembrane receptor | NA | NA | 4.0e-02 | BCL2L1,CXCL10 | NA |
| PRKD2 | 3.00e-02 | kinase | NA | NA | 4.0e-02 | F3,KDR | NA |
| PLSCR1 | 1.90e-01 | enzyme | NA | NA | 4.0e-02 | CDKN1A,MYC | NA |
| HSPB2 | 1.50e-01 | other | NA | NA | 4.0e-02 | CCL2,CD40LG | NA |
| FGF13 | 4.80e-01 | growth factor | NA | NA | 4.0e-02 | CDKN1A,MMP9 | NA |
| CRIP1 | -7.00e-02 | other | NA | NA | 4.0e-02 | BBOX1,SOX2 | NA |
| UBP1 | 1.90e-01 | transcription regulator | NA | NA | 4.0e-02 | CD79A,GRHL1 | NA |
| MC3R | NA | G-protein coupled receptor | NA | NA | 4.0e-02 | Ccl2,HMOX1 | NA |
| NEK10 | NA | kinase | NA | NA | 4.0e-02 | CDKN1A,GADD45A | NA |
| BCL2L12 | -7.00e-02 | other | NA | NA | 4.0e-02 | CDKN1A,Pmaip1 | NA |
| PGRMC1 | -8.00e-02 | transmembrane receptor | NA | NA | 4.0e-02 | BCL2A1,LCN2 | NA |
| mir-28 | NA | microRNA | NA | NA | 4.0e-02 | BTLA,CREB1 | NA |
| miR-340-5p (miRNAs w/seed UAUAAAG) | NA | mature microRNA | NA | NA | 4.0e-02 | SRGAP1,TGFA | NA |
| EGFL7 | NA | other | NA | NA | 4.0e-02 | NFKBIA,SELE | NA |
| ENT | NA | group | NA | NA | 4.0e-02 | AQP3,CDKN1A | NA |
| OPRD1 | 2.00e-02 | G-protein coupled receptor | NA | NA | 4.0e-02 | GZMB,PRF1 | NA |
| GNAZ | -5.00e-01 | enzyme | NA | NA | 4.0e-02 | CCL4,CXCL10 | NA |
| SLC8A1 | -4.40e-01 | transporter | NA | NA | 4.0e-02 | EDN1,SELE | NA |
| MMP13 | NA | peptidase | NA | NA | 4.0e-02 | Ccl2,CCL4 | NA |
| BDKRB1 | 4.30e-01 | G-protein coupled receptor | NA | NA | 4.0e-02 | CXCL6,EDN1 | NA |
| TAB2 | 1.10e-01 | other | NA | NA | 4.0e-02 | MMP9,PTGS2 | NA |
| SRPK1 | 8.00e-02 | kinase | NA | NA | 4.0e-02 | BCL2L1,CXCL10 | NA |
| DYNLL1 | -1.02e+00 | other | NA | NA | 4.0e-02 | CDKN1A,FOS | NA |
| SPIN1 | -6.00e-02 | other | NA | NA | 4.0e-02 | C1QTNF1,IFI44L | NA |
| STK38 | NA | kinase | NA | NA | 4.0e-02 | CXCL2,CXCL3 | NA |
| F2RL3 | 2.30e-01 | G-protein coupled receptor | NA | NA | 4.0e-02 | FOS,SELP | NA |
| PSMD4 | 1.90e-01 | other | NA | NA | 4.0e-02 | CD14,CD69 | NA |
| STX2 | -2.60e-01 | transporter | NA | NA | 4.0e-02 | BMP2,MYC | NA |
| ASGR1 | -5.20e-01 | transmembrane receptor | NA | NA | 4.0e-02 | APOB,MMP9 | NA |
| glaucocalyxin A | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | LCN2,PTGS2 | NA |
| EEF2K | 1.90e-01 | kinase | NA | NA | 4.0e-02 | BCL2L1,CDKN1A | NA |
| BTG1 | 4.70e-01 | transcription regulator | NA | NA | 4.0e-02 | BCL2L1,PTGS2 | NA |
| norisoboldine | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | CPT1A,MMP9 | NA |
| RAP1A | -1.40e-01 | enzyme | NA | NA | 4.0e-02 | CDKN1A,THBS1 | NA |
| HIVEP2 | 2.90e-01 | transcription regulator | NA | NA | 4.0e-02 | FOS,MYC | NA |
| CALCRL | -6.80e-01 | G-protein coupled receptor | NA | NA | 4.0e-02 | CALCRL,CCL2 | NA |
| tofogliflozin | NA | chemical drug | NA | NA | 4.0e-02 | CPT1A,FASN | NA |
| RPS20 | NA | other | NA | NA | 4.0e-02 | CDKN1A,MYC | NA |
| CD300C | -1.29e+00 | transmembrane receptor | NA | NA | 4.0e-02 | CXCL2,IL12B | NA |
| Hrg | -5.90e-01 | other | NA | NA | 4.0e-02 | CCL2,MMP9 | NA |
| PAXIP1 | NA | other | NA | NA | 4.0e-02 | CDKN1A,ENO3 | NA |
| PILRA | NA | other | NA | NA | 4.0e-02 | Ccl2,CXCL2 | NA |
| OBP2B | NA | transporter | NA | NA | 4.0e-02 | CPT1A,FASN | NA |
| VTX-2337 | NA | chemical drug | NA | NA | 4.0e-02 | Ccl2,GZMB | NA |
| equol | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | BCL2L1,MYC | NA |
| ZYX | -6.00e-02 | other | NA | NA | 4.0e-02 | FOS,HIPK2 | NA |
| SET | -1.00e-02 | phosphatase | NA | NA | 4.0e-02 | BCL2L1,GZMB | NA |
| LGH447 | NA | chemical drug | NA | NA | 4.0e-02 | MMP9,MYC | NA |
| fenebrutinib | NA | chemical drug | NA | NA | 4.0e-02 | MYC,POU2F2 | NA |
| COG112 peptide | NA | chemical reagent | NA | NA | 4.0e-02 | CXCL2,CXCL3 | NA |
| UCA1 | NA | other | NA | NA | 4.0e-02 | ABCB1,SLC7A5 | NA |
| 6,7-dinitroquinoxaline-2,3-dione | NA | chemical reagent | NA | NA | 4.0e-02 | FOS,JUNB | NA |
| ferric nitrilotriacetate | NA | chemical toxicant | NA | NA | 4.0e-02 | BCL2L1,PTGS2 | NA |
| BML-284 | NA | chemical reagent | NA | NA | 4.0e-02 | CD274,CPT1B | NA |
| emricasan | NA | chemical drug | NA | NA | 4.0e-02 | CXCL2,CXCL3 | NA |
| pyridoxamine | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CRP,SERPINE1 | NA |
| butylated hydroxytoluene | NA | chemical toxicant | NA | NA | 4.0e-02 | FOS,PTGS2 | NA |
| 6-cyano-7-nitroquinoxaline-2,3-dione | NA | chemical reagent | NA | NA | 4.0e-02 | FOS,JUNB | NA |
| halothane | NA | chemical drug | NA | NA | 4.0e-02 | FOS,Klrk1 | NA |
| eprosartan | NA | chemical drug | NA | NA | 4.0e-02 | ABCC2,SERPINE1 | NA |
| dibenzoylmethane | NA | chemical toxicant | NA | NA | 4.0e-02 | CDKN1A,PTGS2 | NA |
| Z-VRPR-FMK | NA | chemical - protease inhibitor | NA | NA | 4.0e-02 | BCL2A1,BCL2L1 | NA |
| sevelamer | NA | chemical drug | NA | NA | 4.0e-02 | NR0B2,TGFA | NA |
| juglone | NA | chemical toxicant | NA | NA | 4.0e-02 | AR,FASN | NA |
| RAM2061 | NA | chemical reagent | NA | NA | 4.0e-02 | ATF4,ERN1 | NA |
| NHB2005 | NA | chemical reagent | NA | NA | 4.0e-02 | ATF4,ERN1 | NA |
| edelfosine | NA | chemical drug | NA | NA | 4.0e-02 | AR,ATF3 | NA |
| 13-hydroxyoctadecadienoic acid | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | IL12B,NR0B2 | NA |
| sparfosic acid | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A,TP73 | NA |
| quisqualic acid | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | FOS,JUNB | NA |
| CTR9 | -9.00e-02 | other | NA | NA | 4.0e-02 | EGR3,Meis1,MYC,RASGRP1 | NA |
| LYL1 | -5.10e-01 | transcription regulator | NA | NA | 4.0e-02 | BCL2L1,BTG2,ID4,SCN1B | NA |
| resolvin D2 | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | Ccl2,CXCL3,HMOX1,SELL | NA |
| TRPV1 | 7.10e-01 | ion channel | NA | NA | 4.0e-02 | FOS,MAP1LC3B,PTGS2,TRPV1 | NA |
| FBN1 | 1.50e-01 | other | NA | NA | 4.0e-02 | INHBA,MMP9,SERPINE1,TIMP3 | NA |
| WNT7A | -8.10e-01 | cytokine | NA | NA | 4.0e-02 | CHRNA7,MMP9,PLAUR,WNT5A | NA |
| ZBTB7A | 2.20e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A,FOS,MYC,NRP1,SELE | NA |
| MEIS1 | NA | transcription regulator | NA | NA | 4.0e-02 | CDKN1A,DLK1,FOS,Meis1,XCL1 | NA |
| BRAF | -1.40e-01 | kinase | NA | NA | 4.0e-02 | ADAMTS9,ATF4,B3GNT5,Ccl2,CDKN1A,CNTN3,CXCL2,ERBB3,EREG,F3,GALNT3,IL1A,LOXL1,MMP9,MYC,NGFR,PLAUR,RND3,SERPINE1,SLC7A1,THBS1,TIMP1 | NA |
| Ap2 | NA | group | NA | NA | 4.0e-02 | ALB,APOB,ERBB3,MCAM,PCK1 | NA |
| TFDP1 | 1.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CCNA1,CDKN1A,MYC,MYCN,TP73 | NA |
| SFPQ | -7.00e-01 | other | NA | NA | 4.0e-02 | AR,ECE1,FOSL1,LPIN1,TNFRSF8 | NA |
| PBX1 | -3.20e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A,GNRH1,Meis1,MMP9,NFIL3 | NA |
| TRA | NA | transmembrane receptor | NA | NA | 4.0e-02 | CD79A,CDKN1A,IL12B,SOCS3 | NA |
| MSX1 | -4.40e-01 | transcription regulator | NA | NA | 4.0e-02 | BMP2,CDKN1A,COL2A1,EPHA4 | NA |
| SSTR2 | -2.30e-01 | G-protein coupled receptor | NA | NA | 4.0e-02 | FOS,HDC,MMP9,THBS1 | NA |
| ketamine | NA | chemical drug | NA | NA | 4.0e-02 | CREM,FOS,HMOX1,PTGS2 | NA |
| nystatin | NA | chemical drug | NA | NA | 4.0e-02 | IL12B,LCN2,TIMP1 | NA |
| estrone | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | AR,IRS1,SERPINE1 | NA |
| (Z,E)-5-(4-ethylbenzylidine)-2-thioxothiazolidin-4-one | NA | chemical reagent | NA | NA | 4.0e-02 | EZH2,GLI1,MYC | NA |
| HNF4α dimer | NA | complex | NA | NA | 4.0e-02 | KCNJ11,PON1,SLC22A7 | NA |
| APOL1 | NA | transporter | NA | NA | 4.0e-02 | CXCL2,MUC13,MYC | NA |
| USP38 | -3.00e-02 | peptidase | NA | NA | 4.0e-02 | CXCL2,CXCL3,TIMP1 | NA |
| BV6 | NA | chemical reagent | NA | NA | 4.0e-02 | CCL2,CD83,SIX1 | NA |
| CLCN5 | -5.00e-02 | ion channel | NA | NA | 4.0e-02 | Ccl2,CUBN,IL12B | NA |
| FOXG1 | -7.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A,PCK1,SERPINE1 | NA |
| 48s | NA | complex | NA | NA | 4.0e-02 | ATF4,MYC,MYCN | NA |
| CHRNA1 | -1.50e-01 | transmembrane receptor | NA | NA | 4.0e-02 | CD28,CD40LG,CD69 | NA |
| Betacatenin/TCF | NA | complex | NA | NA | 4.0e-02 | DKK2,MYC,NR5A2 | NA |
| SPTLC2 | 2.70e-01 | enzyme | NA | NA | 4.0e-02 | ATF4,THBS1,TIMP1 | NA |
| SMC3 | -7.00e-02 | other | NA | NA | 4.0e-02 | MYC,ODC1,THBS1 | NA |
| FERMT2 | 2.60e-01 | other | NA | NA | 4.0e-02 | Ccl2,FASN,GLI1 | NA |
| GHRHR | 1.43e+00 | G-protein coupled receptor | NA | NA | 4.0e-02 | FOS,GHRHR,HSD11B2 | NA |
| GLUL | 1.34e+00 | enzyme | NA | NA | 4.0e-02 | CXCR4,GLUL,SLC7A5 | NA |
| PIKFYVE | 7.00e-02 | kinase | NA | NA | 4.0e-02 | ATF3,MAP1LC3B,SIGLEC8 | NA |
| CAPN3 | -2.80e-01 | peptidase | NA | NA | 4.0e-02 | DUSP1,HMOX1,PTGS2 | NA |
| NHLH2 | -6.00e-02 | transcription regulator | NA | NA | 4.0e-02 | ADGRE1,GNRH1,TRH | NA |
| ZHX2 | -1.70e-01 | transcription regulator | NA | NA | 4.0e-02 | HDC,PFKFB3,ZEB2 | NA |
| KPNB1 | 1.80e-01 | other | NA | NA | 4.0e-02 | DLL1,MYC,SOX2 | NA |
| CCL19 | -7.90e-01 | cytokine | NA | NA | 4.0e-02 | BCL2L1,CCL19,CXCL10 | NA |
| ITIH1 | -5.60e-01 | other | NA | NA | 4.0e-02 | IL12B,SPHK1,TNFAIP6 | NA |
| MYH9 | NA | enzyme | NA | NA | 4.0e-02 | MYC,SOX2,WNT5A | NA |
| ginkgolide B | NA | chemical drug | NA | NA | 4.0e-02 | CCL2,CD40LG,SELP | NA |
| hydroxyflutamide | NA | chemical drug | NA | NA | 4.0e-02 | AR,GNRH1,IL1A | NA |
| chlorogenic acid | NA | chemical drug | NA | NA | 4.0e-02 | CCL2,HMOX1,PTGS2 | NA |
| Mn(III)-tetrakis-(4-benzoic acid) porphyrin | NA | chemical reagent | NA | NA | 4.0e-02 | CLDN4,SELE,SERPINE1 | NA |
| NUP98-KDM5A | NA | fusion gene/product | NA | NA | 4.0e-02 | C3AR1,Meis1,MYC | NA |
| fevipiprant | NA | chemical drug | NA | NA | 4.0e-02 | NRP1,PTGS2,TNFRSF12A | NA |
| formoterol | NA | chemical drug | NA | NA | 4.0e-02 | CXCL10,FOSL1,MMP9 | NA |
| SETDB1 | 0.00e+00 | enzyme | NA | NA | 5.0e-02 | ANO2,CBLB,HMOX1,IFI44,IFI44L,Klrk1 | NA |
| CDC73 | -1.80e-01 | other | NA | NA | 5.0e-02 | LGALS3,Meis1,MYC,STAT1 | NA |
| CD9 | 3.00e-02 | other | NA | NA | 5.0e-02 | CD69,MMP9,MYC,WNT5A | NA |
| Saa3 | NA | other | NA | NA | 5.0e-02 | BMP2,MMP9,RAMP3,S100A8 | NA |
| TAF4B | 3.70e-01 | transcription regulator | NA | NA | 5.0e-02 | IER3,INHBA,NFKBIA,ZBTB16 | NA |
| aristolochic acid I | NA | chemical toxicant | NA | NA | 5.0e-02 | CDKN1A,FOS,HMOX1,MCCC2 | NA |
Lung %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S8. Ingenuity upstream regulators predicted to have similar activatory or inhibitory effect to ozone in Lung - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))read_excel("../input_files/Upstream/Hypothalamus_upstream analysis.xls") %>% row_to_names(row_number=1) -> HT## New names:
## • `` -> `...2`
## • `` -> `...3`
## • `` -> `...4`
## • `` -> `...5`
## • `` -> `...6`
## • `` -> `...7`
## • `` -> `...8`as.numeric(HT$`Activation z-score`) -> HT$`Activation z-score`
HT <- HT[order(-HT$`Activation z-score`),]
as.numeric(HT$`Expr Log Ratio`) -> HT$`Expr Log Ratio`
as.numeric(HT$`p-value of overlap`) -> HT$`p-value of overlap`
HT %>%
mutate(
`Expr Log Ratio`=format(round(`Expr Log Ratio`,2),nsmall=2,scientific=TRUE),
`Activation z-score`=format(round(`Activation z-score`,2),nsmall=2,scientific=TRUE),
`p-value of overlap`=format(round(`p-value of overlap`,2),nsmall=2,scientific=TRUE)) %>%
kable(caption = "Supplementary Table S8. Ingenuity upstream regulators predicted to have similar activatory or inhibitory effect to ozone in HT", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(1:8,bold=ifelse(is.na(HT$`Predicted Activation State`),F,T),color= ifelse(is.na(HT$`Predicted Activation State`),"gray",ifelse(HT$`Predicted Activation State` == "Inhibited","#40004B","#00441B"))) %>%
scroll_box(width = "1200px", height = "500px")| Upstream Regulator | Expr Log Ratio | Molecule Type | Predicted Activation State | Activation z-score | p-value of overlap | Target Molecules in Dataset | Mechanistic Network |
|---|---|---|---|---|---|---|---|
| dexamethasone phosphate | NA | chemical drug | Activated | 2.98e+00 | 0.0e+00 | Arrdc2,CXCR4,GADD45G,GPD1,Mt1,NFKBIA,PLEKHF1,SGK1,TNFRSF11B | 47 (7) |
| corticosterone | NA | chemical - endogenous mammalian | Activated | 2.87e+00 | 0.0e+00 | CCND1,CDKN1A,DOCK8,FKBP5,FOS,HIF3A,MFSD2A,PNPLA2,SGK1,TLR2 | 80 (21) |
| aspirin | NA | chemical drug | Activated | 2.80e+00 | 0.0e+00 | AFAP1L1,AHR,CCND1,CDKN1A,CXCR4,KITLG,NCF1,POSTN | 100 (21) |
| plicamycin | NA | chemical drug | Activated | 2.77e+00 | 0.0e+00 | ADAMTS4,AFAP1L1,AHR,CDKN1A,GPD1,ROR1,SLC40A1,TESC | NA |
| PPARG | -1.20e-01 | ligand-dependent nuclear receptor | Activated | 2.72e+00 | 0.0e+00 | CCND1,CDKN1A,EHHADH,GPD1,INSIG1,NCF1,PEX11A,PLA2G3,PLIN4,PLIN5,SFTPB,SGK1,SLC2A1,TLR4 | 95 (20) |
| ciprofibrate | NA | chemical drug | Activated | 2.50e+00 | 0.0e+00 | CXCL12,DBI,EHHADH,LCN2,NFKBIA,PEX11A,RBM3 | 75 (14) |
| troglitazone | NA | chemical drug | Activated | 2.49e+00 | 0.0e+00 | ATP10B,CCND1,CDKN1A,CRYAB,DBI,FOS,GPD1,MLXIPL,NCF1,NFKBIA,P4HA1,PEX11A,PLIN4,SLC2A1 | 100 (21) |
| fluticasone propionate | NA | chemical drug | Activated | 2.45e+00 | 1.0e-02 | C1QB,CLEC12A,FKBP5,GBP5,IL1R2,MERTK | NA |
| JQ1 | NA | chemical reagent | Activated | 2.43e+00 | 0.0e+00 | CCND1,CXCR4,FOS,GADD45G,NFKBIA,TLR2,TLR4 | 96 (19) |
| staurosporine | NA | chemical drug | Activated | 2.43e+00 | 0.0e+00 | CCND1,CDKN1A,CSF3R,ERBB3,FOS,NCF1 | 93 (23) |
| PGR | -1.20e-01 | ligand-dependent nuclear receptor | Activated | 2.42e+00 | 4.0e-02 | CA12,CCND1,CDKN1A,FKBP5,FOS,NFKBIA,POSTN,SGK1,TGFB3 | NA |
| PPARD | 4.70e-01 | ligand-dependent nuclear receptor | Activated | 2.40e+00 | 0.0e+00 | ADORA1,C1QB,CCND1,GPD1,Irgm1,MERTK,MFSD2A,PNPLA2,TNFRSF11B | 44 (7) |
| SREBF1 | 3.20e-01 | transcription regulator | Activated | 2.36e+00 | 0.0e+00 | CDKN1A,DBI,EHHADH,ELOVL7,IL1R2,INSIG1,LGALS3,PLA2G3 | 73 (15) |
| triptolide | NA | chemical drug | Activated | 2.33e+00 | 0.0e+00 | AFAP1L1,AHR,CCR5,CDKN1A,CXCL12,KITLG,POSTN,TLR2,TLR4 | 63 (20) |
| PPARA | 9.00e-02 | ligand-dependent nuclear receptor | Activated | 2.30e+00 | 0.0e+00 | C1QB,CCND1,CDKN1A,CXCL12,CYBB,DBI,EHHADH,FOS,GPD1,INSIG1,NCF1,NFKBIA,PEX11A,PLIN4,PLIN5,PNPLA2,TLR2 | 71 (20) |
| levodopa | NA | chemical - endogenous mammalian | Activated | 2.30e+00 | 0.0e+00 | CA12,CCND1,CIART,CXCL12,CYTH4,FKBP5,FOS,GPD1,INSC,MFSD2A,NRARP,PER1,PLEK,SLC2A1 | 91 (21) |
| pirinixic acid | NA | chemical toxicant | Activated | 2.29e+00 | 0.0e+00 | CCND1,CDKN1A,CXCL12,DBI,EHHADH,GPD1,ID2,INSIG1,LCN2,LGALS3,NFKBIA,PEX11A,PLIN4,PLIN5 | 79 (17) |
| bezafibrate | NA | chemical drug | Activated | 2.20e+00 | 0.0e+00 | DBI,EHHADH,INSIG1,LGALS3,PEX11A | 71 (12) |
| BCR-ABL1 | NA | fusion gene/product | Activated | 2.19e+00 | 0.0e+00 | AURKB,CCND1,CSF3R,CXCR4,LCN2,SLC2A1 | 101 (22) |
| 4-phenylbutyric acid | NA | chemical - endogenous mammalian | Activated | 2.18e+00 | 0.0e+00 | ASPA,CCND1,CDKN1A,CXCL12,EHHADH,PEX11A | 97 (22) |
| PTGER4 | -2.00e-01 | G-protein coupled receptor | Activated | 2.16e+00 | 0.0e+00 | ADAMTS4,CXCR4,CYBB,Ifi47,Irgm1,NCF1,RNF213,SHISA3 | NA |
| epigallocatechin-gallate | NA | chemical drug | Activated | 2.07e+00 | 1.0e-02 | AHR,CCND1,CDKN1A,FOS,Ifi47,NFKBIA,TLR4 | 79 (17) |
| TP53 | -9.00e-02 | transcription regulator | Activated | 2.07e+00 | 0.0e+00 | ACER2,AEN,AURKB,CARD11,CCND1,CDKN1A,COL13A1,CRYAB,CSF3R,CXCL12,DBI,DHRS9,FIGNL1,FKBP5,FOS,GADD45G,GPD1,GPR157,GPR179,H2BC5,ID2,IRAK2,KITLG,LAMP3,LCN2,LGALS3,NCF1,NFKBIA,NRARP,P4HA1,POSTN,PRRX2,PTCH1,PTP4A3,RBM3,SGK1,SLC2A1,SLC2A12,TGFB3,TNFRSF11A,UHRF1,WNT7A | 110 (27) |
| xanthohumol | NA | chemical drug | Activated | 2.00e+00 | 0.0e+00 | CCND1,FOS,MYH6,TLR4 | 65 (14) |
| androgen | NA | chemical drug | Activated | 2.00e+00 | 0.0e+00 | CA12,CCND1,CXCR4,ERBB3,FOS,Mt1,NFKBIA | 77 (18) |
| fatty acid | NA | chemical - endogenous mammalian | Activated | 2.00e+00 | 1.0e-02 | AHR,NFKBIA,PLIN4,PLIN5,SLC2A1 | 59 (14) |
| niacinamide | NA | chemical - endogenous mammalian | Activated | 2.00e+00 | 1.0e-02 | CDKN1A,CXCL12,NFYA,SLC34A2 | NA |
| SPARC | 1.20e-01 | other | Activated | 2.00e+00 | 3.0e-02 | CIART,GPD1,SLC34A2,USP2 | NA |
| MYOD1 | 1.00e-01 | transcription regulator | NA | 2.00e+00 | 0.0e+00 | ADORA1,CDKN1A,CRYAB,GADD45G,ID2,MYBPH,MYH6,POSTN,SLC2A1 | 72 (16) |
| rosiglitazone | NA | chemical drug | NA | 2.00e+00 | 0.0e+00 | C1QB,CCND1,CDKN1A,EHHADH,FOS,GPD1,INSIG1,LCN2,LFNG,PEX11A,PLIN5,PNPLA2,POSTN,SGK1,SLC2A1,TGFB3,TLR4 | 83 (21) |
| PTX3 | 2.60e-01 | other | NA | 1.99e+00 | 0.0e+00 | CCR5,FOS,TLR2,TLR4 | 72 (13) |
| NR3C1 | -3.70e-01 | ligand-dependent nuclear receptor | NA | 1.99e+00 | 0.0e+00 | CCND1,CCR5,CDKN1A,CRYAB,CXCR4,DBI,FKBP5,FOS,IP6K3,LCN2,MFSD2A,Mt1,Mt1m/Mt2A,NFKBIA,NOTCH4,NR0B1,PER1,PLEKHF1,PNPLA2,SGK1,STON1,TLR2,TNFRSF11B | 105 (20) |
| SMAD4 | -1.00e-02 | transcription regulator | NA | 1.98e+00 | 0.0e+00 | CCND1,CDKN1A,FOS,HMCN1,ID2,KITLG,NFKBIA,SFTPB,SGK1 | 103 (23) |
| MEN1 | -1.00e-01 | transcription regulator | NA | 1.98e+00 | 0.0e+00 | CCND1,CDKN1A,FKBP5,FOS | 84 (26) |
| indole-3-carbinol | NA | chemical drug | NA | 1.98e+00 | 0.0e+00 | CCND1,CDKN1A,FOS,Slco1a4 | 90 (25) |
| S-nitroso-N-acetyl-DL-penicillamine | NA | chemical reagent | NA | 1.98e+00 | 0.0e+00 | CDKN1A,CXCL12,SLC2A1,TGFB3 | 100 (23) |
| lactacystin | NA | chemical - protease inhibitor | NA | 1.97e+00 | 0.0e+00 | CCND1,CDKN1A,CRYAB,CXCR4,MCM10,NFKBIA,SFTPB,TLR2 | 87 (23) |
| TSC22D3 | NA | transcription regulator | NA | 1.96e+00 | 0.0e+00 | CCND1,CDKN1A,SGK1,TLR2 | 91 (21) |
| FOXO4 | -2.50e-01 | transcription regulator | NA | 1.96e+00 | 0.0e+00 | CCND1,CDKN1A,ELOVL7,SGK1,SLC2A1 | 63 (16) |
| CREM | -1.20e-01 | transcription regulator | NA | 1.96e+00 | 6.0e-02 | CCND1,CIART,FOS,PER1 | NA |
| mir-8 | NA | microRNA | NA | 1.96e+00 | 1.2e-01 | CCND1,CDKN1A,Fhod1,KITLG | NA |
| Tlr | NA | group | NA | 1.95e+00 | 0.0e+00 | GPR34,ID2,LCN2,NFKBIA,RGS1 | 99 (14) |
| indomethacin | NA | chemical drug | NA | 1.95e+00 | 0.0e+00 | CCND1,CDKN1A,Ctla2a,CXCR4,FOS,LCN2,LGALS3,RBM3,SLC34A2 | 88 (21) |
| valsartan | NA | chemical drug | NA | 1.94e+00 | 0.0e+00 | CYBB,FOS,NCF1,POSTN | 108 (22) |
| AGN194204 | NA | chemical drug | NA | 1.91e+00 | 1.0e-02 | AHR,CDKN1A,DOCK8,Ifi47,IL1R2,PLIN4,SEMA4B | NA |
| allopurinol | NA | chemical drug | NA | 1.91e+00 | 0.0e+00 | Ctla2a,LCN2,LGALS3,RBM3,SLC2A1,SLC34A2,TLR4 | 66 (7) |
| docosahexaenoic acid | NA | chemical drug | NA | 1.91e+00 | 0.0e+00 | CDKN1A,CXCR4,FOS,MLXIPL,PNPLA2,SLC2A1,TGFB3 | 73 (18) |
| progesterone | NA | chemical - endogenous mammalian | NA | 1.90e+00 | 0.0e+00 | CA12,CCND1,CCR5,CDH11,CDKN1A,CRYAB,CSF3R,CXCL12,CXCR4,ERBB3,FKBP5,FOS,LCN2,LGALS3,NFKBIA,PLIN4,POSTN,SGK1,SLC2A1,SPSB1,TGFB3 | 114 (19) |
| dexamethasone | NA | chemical drug | NA | 1.89e+00 | 0.0e+00 | ATP10B,C1QB,CCND1,CDH11,CDKN1A,CRYAB,CXCL12,CXCR4,CYBB,DHRS9,EHHADH,FKBP5,FOS,GBP5,GPR34,HELZ2,ID2,IL1R2,IP6K3,LCN2,LGALS3,MERTK,Mt1,MYH6,NFKBIA,NOTCH4,NR0B1,P4HA1,PER1,PLEK,PNPLA2,Podxl,POSTN,RGS1,ROR1,SFTPB,SGK1,SH3TC1,SLC10A6,SLC26A2,SLC2A1,SLC40A1,Slco1a4,SPSB1,STON1,TGFB3,TLR2,TLR4,TNFRSF11B,USP2,ZBTB16,ZNF189 | 107 (22) |
| pyrrolidine dithiocarbamate | NA | chemical reagent | NA | 1.77e+00 | 0.0e+00 | CCR5,CXCR4,NFKBIA,SLC2A1,TLR2,TLR4 | 83 (17) |
| celecoxib | NA | chemical drug | NA | 1.77e+00 | 0.0e+00 | CCND1,CDKN1A,FOS,TLR2,TLR4,TNFRSF11A | 81 (19) |
| phenylbutazone | NA | chemical drug | NA | 1.77e+00 | 0.0e+00 | CCND1,Ctla2a,LCN2,LGALS3,RBM3,SLC34A2 | NA |
| prednisolone | NA | chemical drug | NA | 1.76e+00 | 0.0e+00 | CXCR4,EVA1A,FKBP5,FMO2,Irgm1,NOTCH4,SGK1,TNFRSF11B,ZBTB16 | 56 (11) |
| IL4 | NA | cytokine | NA | 1.75e+00 | 0.0e+00 | ADAMTS4,AHR,CCND1,CCR5,CDKN1A,CHST3,CNR2,CSF3R,CXCR4,CYBB,EHHADH,FKBP5,FOS,GADD45G,GBP5,H2BC5,IL1R2,IRAK2,Irgm1,KITLG,LFNG,LGALS3,MERTK,MFSD2A,NFKBIA,PIK3C2B,POSTN,PSTPIP1,RASGRP3,RNF213,SHISA3,SLC19A3,SLC2A1,TGFB3,TLR2,TLR4,TNFRSF11A,TNFRSF11B,USP2 | 102 (20) |
| 15-deoxy-delta-12,14 -PGJ 2 | NA | chemical - endogenous mammalian | NA | 1.75e+00 | 0.0e+00 | ADAMTS4,CCND1,CDKN1A,CYBB,FOS,NFKBIA,P4HA1,Podxl,SFTPB | 86 (20) |
| CREB1 | -4.20e-01 | transcription regulator | NA | 1.75e+00 | 0.0e+00 | CCND1,CDH11,CDKN1A,CIART,CXCR4,FOS,GADD45G,H2-T22,LCN2,MFSD2A,PER1,RSPO2,RUNX1T1,SFTPB,SGK1,SYNJ2 | 81 (19) |
| methylprednisolone | NA | chemical drug | NA | 1.74e+00 | 0.0e+00 | ASPA,C1QB,CCND1,CD180,CDKN1A,CYBB,DHRS9,FOS,GPD1,INSIG1,MLXIPL,Mt1,NFKBIA,PEX11A,PIK3AP1,SGK1,SLC40A1,TLR2,TLR4,USP2 | 101 (22) |
| DKK1 | NA | growth factor | NA | 1.73e+00 | 0.0e+00 | CCND1,CDKN1A,MYH6,WNT7A | 77 (17) |
| mir-21 | NA | microRNA | NA | 1.72e+00 | 0.0e+00 | C1QB,Casp12,CD180,CDKN1A,CSF3R,GBP5,Ifi47,Irgm1,PILRB,TLR2,TLR4 | 90 (19) |
| KL | -6.00e-02 | enzyme | NA | 1.70e+00 | 0.0e+00 | CCND1,CDKN1A,CYBB,MERTK,SLC34A2,TNFRSF11B | 86 (23) |
| KLF6 | -2.80e-01 | transcription regulator | NA | 1.69e+00 | 0.0e+00 | AHR,CDKN1A,CYBB,ID2,IRAK2,LGALS3,NFKBIA,PTCH1,SGK1,SPSB1 | 75 (18) |
| FOXO3 | 1.00e-02 | transcription regulator | NA | 1.67e+00 | 0.0e+00 | AHR,CCND1,CDKN1A,CXCR4,ELOVL7,FOS,LCN2,Mt1,NFKBIA,SGK1,SLC40A1 | 86 (15) |
| NQO1 | 1.60e-01 | enzyme | NA | 1.66e+00 | 0.0e+00 | CCND1,CDKN1A,CSF3R,CXCL12,CXCR4,SLC2A1 | 92 (20) |
| metformin | NA | chemical drug | NA | 1.63e+00 | 0.0e+00 | AHR,CCND1,CDKN1A,CXCL12,FOS,GADD45G,GPD1,Ifi47,INSIG1,NFKBIA,SLC2A1 | 77 (20) |
| ADIPOQ | 4.00e-02 | other | NA | 1.59e+00 | 0.0e+00 | CCND1,CDKN1A,CYBB,FOS,FZD9,GPD1,MLXIPL,NCF1,NFKBIA | 71 (18) |
| PD98059 | NA | chemical - kinase inhibitor | NA | 1.58e+00 | 0.0e+00 | CCND1,CDKN1A,CXCR4,FKBP5,FOS,INSIG1,NFKBIA,NR0B1,PER1,POSTN,RGS1,SLC26A2,SLC2A1,TGFB3,TLR2,TLR4,TNFRSF11A,TNFRSF11B | 69 (15) |
| cyclosporin A | NA | biologic drug | NA | 1.53e+00 | 0.0e+00 | ADORA1,CCND1,CCR5,CDH11,CDKN1A,Ctla2a,CXCR4,FKBP5,FOS,LCN2,LGALS3,NFKBIA,POSTN,RBM3,SLC34A2 | 105 (23) |
| NOTCH1 | -2.00e-02 | transcription regulator | NA | 1.52e+00 | 0.0e+00 | CCND1,CDKN1A,CXCR4,ERBB3,FOS,ID2,LFNG,NCF1,NRARP,SLC2A1,TGFB3 | 85 (22) |
| ARNT | -1.60e-01 | transcription regulator | NA | 1.52e+00 | 0.0e+00 | ACER2,AHR,CCR5,CRYAB,CXCR4,ID2,IL1R2,SLC2A1 | 68 (10) |
| aldosterone | NA | chemical - endogenous mammalian | NA | 1.48e+00 | 0.0e+00 | CYBB,FKBP5,FOS,IP6K3,LCN2,LGALS3,NCF1,NFKBIA,PER1,PGF,POSTN,SGK1,USP2,ZBTB16 | 102 (22) |
| triamcinolone acetonide | NA | chemical drug | NA | 1.46e+00 | 0.0e+00 | COL13A1,FKBP5,FOS,INSIG1,NFKBIA,PER1,ZBTB16,ZNF189 | 48 (7) |
| valproic acid | NA | chemical drug | NA | 1.46e+00 | 0.0e+00 | CA12,CCND1,CDKN1A,CXCR4,DBI,EHHADH,GRHL2,ID2,NFYA,PNPLA2,ROR1,SGK1 | 96 (21) |
| FLT3LG | -1.40e-01 | cytokine | NA | 1.45e+00 | 0.0e+00 | CCR5,CXCL12,CXCR4,CYBB,ID2 | 87 (21) |
| losartan potassium | NA | chemical drug | NA | 1.43e+00 | 1.0e-02 | CYBB,FOS,Ifi47,POSTN,TGFB3 | NA |
| laquinimod | NA | chemical drug | NA | 1.41e+00 | 0.0e+00 | CD93,COL13A1,EVA1A,FKBP5,IL1R2,PGF,SERPINB10,STON1 | NA |
| miR-16-5p (and other miRNAs w/seed AGCAGCA) | NA | mature microRNA | NA | 1.41e+00 | 5.0e-02 | CA12,CCND1,CHORDC1,KITLG,PHLDB2 | NA |
| PTC-209 | NA | chemical reagent | NA | 1.41e+00 | 0.0e+00 | CDKN1A,CRYAB,MYH6,POSTN,TNFRSF11B,USP2 | NA |
| HMOX1 | -1.10e-01 | enzyme | NA | 1.41e+00 | 0.0e+00 | CCND1,CDKN1A,CXCL12,FOS,MYH6,NCF1 | 102 (23) |
| NR4A3 | -4.30e-01 | ligand-dependent nuclear receptor | NA | 1.40e+00 | 1.0e-02 | CCND1,CDKN1A,TGFB3,UHRF1 | NA |
| ELAVL1 | -2.60e-01 | other | NA | 1.40e+00 | 1.0e-02 | CDKN1A,FOS,IL1R2,Irgm1,NFKBIA,TLR2,TLR4 | 70 (13) |
| STAT6 | -2.60e-01 | transcription regulator | NA | 1.40e+00 | 0.0e+00 | CCR5,CDKN1A,CNR2,CYBB,EHHADH,FKBP5,GADD45G,GBP5,H2-T22,Irgm1,NFKBIA,PNPLA2,PSTPIP1,RASGRP3,RNF213,STON1,TNFRSF11A,USP2 | 92 (19) |
| triamterene | NA | chemical drug | NA | 1.39e+00 | 0.0e+00 | Ctla2a,LCN2,LGALS3,RBM3,SLC34A2 | NA |
| CTCF | -2.00e-01 | transcription regulator | NA | 1.39e+00 | 0.0e+00 | CDKN1A,CXCR4,SGK1,TGFB3,TLR2,ZBTB16 | NA |
| N-acetyl-L-cysteine | NA | chemical drug | NA | 1.38e+00 | 0.0e+00 | CCND1,CCR5,CDKN1A,CXCL12,CXCR4,CYBB,FOS,NFKBIA,TLR4 | 76 (18) |
| Insulin | NA | group | NA | 1.36e+00 | 0.0e+00 | CCND1,CDKN1A,CRYAB,CYBB,DBI,EHHADH,FOS,GPD1,HIF3A,INSIG1,MLXIPL,Mt1,NCF1,NFKBIA,NR0B1,PER1,PNPLA2,SFTPB,SGK1,SLC2A1,TLR2 | 101 (21) |
| sulforafan | NA | chemical drug | NA | 1.35e+00 | 1.0e-02 | CCND1,CDKN1A,ERBB3,FOS,Mt1,NFKBIA,RUNX1T1 | NA |
| SB203580 | NA | chemical drug | NA | 1.35e+00 | 0.0e+00 | ADAMTS4,CCND1,CDKN1A,CRYAB,ELOVL7,FOS,NFKBIA,P4HA1,PHLDB2,POSTN,RBM3,SGK1,SLC2A1,TGFB3,TLR2,TLR4,TNFRSF11B | 85 (18) |
| diclofenac | NA | chemical drug | NA | 1.35e+00 | 0.0e+00 | CCND1,CDKN1A,FOS,LGALS3,SLC2A1 | 77 (20) |
| pentoxifylline | NA | chemical drug | NA | 1.34e+00 | 0.0e+00 | CCND1,CCR5,CYBB,FOS,NFKBIA,POSTN | 96 (18) |
| atorvastatin | NA | chemical drug | NA | 1.34e+00 | 0.0e+00 | CXCR4,CYBB,ENPP3,FOS,POSTN,RGS1,SLCO1C1,TGFB3,TLR2,TLR4,TNFRSF11A | 93 (18) |
| 2-bromoethylamine | NA | chemical reagent | NA | 1.34e+00 | 0.0e+00 | Ctla2a,LCN2,LGALS3,RBM3,SLC34A2 | NA |
| gentamicin C | NA | chemical drug | NA | 1.34e+00 | 0.0e+00 | Ctla2a,LCN2,LGALS3,RBM3,SLC34A2 | NA |
| lomustine | NA | chemical drug | NA | 1.34e+00 | 0.0e+00 | Ctla2a,LCN2,LGALS3,RBM3,SLC34A2 | NA |
| CD44 | 2.40e-01 | other | NA | 1.34e+00 | 0.0e+00 | CCND1,CCR5,CDKN1A,FKBP5,IL1R2,LGALS3,PTP4A3,SLC2A1,TNFRSF11A | 92 (25) |
| fenamic acid | NA | chemical reagent | NA | 1.34e+00 | 0.0e+00 | Ctla2a,LCN2,LGALS3,RBM3,SLC34A2 | NA |
| metribolone | NA | chemical reagent | NA | 1.34e+00 | 0.0e+00 | CCND1,CDKN1A,CRYAB,CXCR4,DBI,FKBP5,FOS,GADD45G,INSIG1,MERTK,SLC26A2,TRIM36 | 85 (22) |
| cadmium | NA | chemical toxicant | NA | 1.33e+00 | 0.0e+00 | CCND1,CDKN1A,LGALS3,Mt1,SGK1,SLC22A12 | 81 (23) |
| ciglitazone | NA | chemical drug | NA | 1.31e+00 | 0.0e+00 | CCND1,CDKN1A,CYBB,GPD1,LCN2,NFKBIA,Podxl | 88 (19) |
| Lh | NA | complex | NA | 1.29e+00 | 0.0e+00 | CXCR4,FKBP5,FOS,GADD45G,PER1,RPL10A,RPL6,SGK1,TNFRSF11B,ZBTB16 | 99 (24) |
| (+)-MK-801 | NA | chemical drug | NA | 1.27e+00 | 0.0e+00 | CCND1,CDKN1A,FOS,GJA5,NFKBIA | 90 (24) |
| IL5 | NA | cytokine | NA | 1.26e+00 | 0.0e+00 | CCR5,CDKN1A,CSF3R,CXCR4,GADD45G,IL1R2,LFNG,P4HA1,RBM3,SGK1,SLC2A1 | 119 (24) |
| CD38 | 2.50e-01 | enzyme | NA | 1.25e+00 | 0.0e+00 | CYBB,GADD45G,IL1R2,LFNG,LGALS3,P4HA1,SLC2A1 | NA |
| cyclic AMP | NA | chemical - endogenous mammalian | NA | 1.25e+00 | 0.0e+00 | CCND1,CDKN1A,CRYAB,FOS,NR0B1,PER1,PTCH1,SLC2A1 | 99 (25) |
| Go 6976 | NA | chemical drug | NA | 1.23e+00 | 0.0e+00 | CCND1,CDKN1A,CYBB,FOS,NFKBIA | 73 (19) |
| carbon monoxide | NA | chemical - endogenous mammalian | NA | 1.23e+00 | 0.0e+00 | CDKN1A,CXCL12,NCF1,TLR4 | 84 (24) |
| RBPJ | -2.40e-01 | transcription regulator | NA | 1.22e+00 | 0.0e+00 | CDKN1A,CXCL12,CYTH4,FOS,KITLG,LFNG,PGF,SLC2A1,TGFB3 | 108 (22) |
| BMP4 | -4.80e-01 | growth factor | NA | 1.22e+00 | 0.0e+00 | CCND1,CDKN1A,ID2,PGF,POSTN,PRR5,PTCH1,SLC40A1,TNFRSF11B | 87 (22) |
| WNT1 | NA | cytokine | NA | 1.21e+00 | 1.0e-02 | CCND1,CDKN1A,FOS,GADD45G,NOTCH4 | 88 (21) |
| palbociclib | NA | chemical drug | NA | 1.21e+00 | 1.0e-02 | CCND1,CDKN1A,ID2,PER1 | NA |
| thioacetamide | NA | chemical toxicant | NA | 1.20e+00 | 0.0e+00 | CNR2,Ctla2a,FOS,GPD1,LCN2,LGALS3,MLXIPL,RBM3,SLC34A2,TGFB3,USP2 | 76 (7) |
| eicosapentenoic acid | NA | chemical drug | NA | 1.20e+00 | 0.0e+00 | CCR5,FOS,IL1R2,MLXIPL,PNPLA2,SLC2A1,TGFB3 | 76 (15) |
| IRF2BP2 | 2.00e-02 | transcription regulator | NA | 1.20e+00 | 0.0e+00 | Casp12,CD180,GBP5,ID2,LY86,PILRB,PLEK | NA |
| PRDM1 | 2.00e-01 | transcription regulator | NA | 1.20e+00 | 2.0e-02 | CXCR4,CYTH4,EVA1A,FOS,ID2,LGALS3,PIK3AP1 | NA |
| RUNX3 | 4.00e-02 | transcription regulator | NA | 1.19e+00 | 3.0e-02 | CCND1,CDH11,CDKN1A,CHST3 | NA |
| Notch | NA | group | NA | 1.18e+00 | 0.0e+00 | CDKN1A,CSF3R,ID2,MEX3A,NCF1,PIK3AP1 | 46 (7) |
| FOXO1 | -3.00e-02 | transcription regulator | NA | 1.18e+00 | 4.0e-02 | CCND1,CDKN1A,ELOVL7,FOS,GPD1,MLXIPL,PNPLA2,SGK1,TNFRSF11A | NA |
| bortezomib | NA | chemical drug | NA | 1.16e+00 | 4.0e-02 | CCND1,CDKN1A,CRYAB,CXCL12,CXCR4,PTCH1 | NA |
| propofol | NA | chemical drug | NA | 1.15e+00 | 0.0e+00 | CYBB,FOS,NCF1,TLR4 | 64 (13) |
| IKZF1 | NA | transcription regulator | NA | 1.15e+00 | 0.0e+00 | CDKN1A,CNR2,KITLG,NRARP,RNF213,SLC2A1,SPSB1,TLR4 | 73 (7) |
| pioglitazone | NA | chemical drug | NA | 1.15e+00 | 1.0e-02 | CCND1,CDKN1A,FOS,NCF1,SLC2A1,TNFRSF11A | NA |
| simvastatin | NA | chemical drug | NA | 1.13e+00 | 0.0e+00 | CCND1,CDKN1A,CYBB,FOS,LCN2,NCF1,NFKBIA,TLR2,TLR4,TNFRSF11B | 79 (19) |
| PD173074 | NA | chemical reagent | NA | 1.12e+00 | 1.0e-02 | CCND1,PGF,PRR5,SLC40A1 | NA |
| AR | -7.00e-02 | ligand-dependent nuclear receptor | NA | 1.12e+00 | 0.0e+00 | CCND1,CDH11,CDKN1A,CXCL12,ERBB3,FKBP5,GADD45G,GPD1,GPR179,KITLG,MYH6,NR0B1,P4HA1,PER1,PTCH1,SGK1,TLR4,ZBTB16 | 96 (20) |
| MM-589 | NA | chemical reagent | NA | 1.11e+00 | 0.0e+00 | CRYAB,MYH6,POSTN,TNFRSF11B,USP2 | NA |
| mibolerone | NA | chemical drug | NA | 1.11e+00 | 1.0e-02 | AHR,CCND1,DBI,FKBP5,GADD45G | 78 (7) |
| NR3C2 | -3.20e-01 | ligand-dependent nuclear receptor | NA | 1.10e+00 | 0.0e+00 | CCR5,CXCR4,FKBP5,LCN2,PGF,PLIN4,SGK1 | 67 (12) |
| promegestone | NA | chemical drug | NA | 1.09e+00 | 0.0e+00 | CCND1,CDKN1A,ERBB3,FKBP5,NFKBIA,SGK1,ZBTB16 | 109 (25) |
| PRKAA | NA | group | NA | 1.09e+00 | 0.0e+00 | CCND1,CDKN1A,FKBP5,NCF1 | 106 (26) |
| IGF1 | -2.70e-01 | growth factor | NA | 1.09e+00 | 0.0e+00 | CCND1,CDKN1A,CRYAB,CYBB,FOS,GADD45G,GPD1,ID2,LCN2,MYH6,NFKBIA,PHLDB2,PLEK,POSTN,SGK1,SLC2A1,TLR4,TNFRSF11B,USP2 | 90 (19) |
| miR-34a-5p (and other miRNAs w/seed GGCAGUG) | NA | mature microRNA | NA | 1.07e+00 | 0.0e+00 | BIN2,CCND1,CDKN1A,DOCK8,MCM10,PLCB2,POU3F2,PTCH1 | 35 (7) |
| curcumin | NA | chemical drug | NA | 1.07e+00 | 0.0e+00 | ADAMTS4,BANP,CCND1,CDKN1A,CXCR4,EHHADH,FOS,NFKBIA,PGF,PNPLA2,POU3F2,TLR2,TLR4,TNFRSF11A | 85 (17) |
| herbimycin | NA | chemical drug | NA | 1.07e+00 | 0.0e+00 | CCND1,CXCR4,FOS,TNFRSF11B | 74 (18) |
| hexachlorobenzene | NA | chemical toxicant | NA | 1.07e+00 | 0.0e+00 | Ctla2a,LCN2,LGALS3,SLC34A2 | NA |
| mycophenolic acid | NA | chemical drug | NA | 1.07e+00 | 1.0e-02 | CDKN1A,CXCR4,CYBB,ID2 | 69 (12) |
| flutamide | NA | chemical drug | NA | 1.07e+00 | 1.0e-02 | FOS,GPD1,KITLG,PTCH1 | NA |
| INSIG1 | 7.30e-01 | other | NA | 1.07e+00 | 2.0e-02 | CCR5,CXCR4,LCN2,MLXIPL | NA |
| DDIT3 | 7.00e-02 | transcription regulator | NA | 1.07e+00 | 3.0e-02 | CA6,IRAK2,LCN2,PER1 | NA |
| mifepristone | NA | chemical drug | NA | 1.05e+00 | 0.0e+00 | C1QB,CCND1,CDKN1A,CYBB,FKBP5,FOS,Mt1,NFKBIA,POSTN,SLC2A1 | 115 (26) |
| forskolin | NA | chemical toxicant | NA | 1.05e+00 | 0.0e+00 | ACER2,ADAMTS4,CCND1,CDKN1A,CRYAB,CXCR4,FKBP5,FOS,GADD45G,ID2,KITLG,MFSD2A,Mt1,NFKBIA,PER1,PRLHR,SFTPB,SGK1,SLC2A1,Slco1a4,SYNJ2,TNFRSF11B | 100 (22) |
| SP600125 | NA | chemical drug | NA | 1.03e+00 | 0.0e+00 | ADAMTS4,CCND1,CDKN1A,CXCR4,FOS,MYH6,NFKBIA,PER1,POSTN,TLR4 | 76 (18) |
| selumetinib | NA | chemical drug | NA | 1.03e+00 | 0.0e+00 | CCND1,CDKN1A,ERBB3,FOS,MERTK,SLC2A1,WNT7A | 90 (23) |
| DRD2 | 1.10e-01 | G-protein coupled receptor | NA | 1.02e+00 | 0.0e+00 | C1QB,CRYAB,FOS,NFKBIA,PNPLA2 | 85 (21) |
| deferoxamine | NA | chemical drug | NA | 1.01e+00 | 0.0e+00 | CCND1,CDKN1A,FOS,LCN2,PLA2G3,RGS1,SLC2A1 | 74 (22) |
| isoprenaline | NA | chemical drug | NA | 1.00e+00 | 0.0e+00 | FOS,PER1,PNPLA2,SLC2A1 | 64 (14) |
| IRF2 | 2.00e-01 | transcription regulator | NA | 1.00e+00 | 0.0e+00 | CA12,CCND1,CDKN1A,Ifi47,LCN2,TLR4 | 45 (7) |
| carboplatin | NA | chemical drug | NA | 1.00e+00 | 0.0e+00 | LCN2,LGALS3,RBM3,SLC34A2 | NA |
| TLR3 | -3.00e-01 | transmembrane receptor | NA | 1.00e+00 | 0.0e+00 | ADAMTS4,FOS,Ifi47,IL1R2,LCN2,NFE2L3,RGS1,TLR4 | 84 (18) |
| trovafloxacin | NA | chemical drug | NA | 1.00e+00 | 0.0e+00 | CDKN1A,FOS,MLXIPL,NFKBIA | NA |
| rotenone | NA | chemical toxicant | NA | 1.00e+00 | 0.0e+00 | CCND1,CYBB,FOS,GADD45G | 95 (21) |
| prexasertib | NA | chemical drug | NA | 1.00e+00 | 1.0e-02 | CDKN1A,FOS,NFKBIA,SGK1 | 87 (12) |
| GPR174 | 1.20e-01 | G-protein coupled receptor | NA | 1.00e+00 | 1.0e-02 | CARD11,CD180,CHST3,CYBB | NA |
| TRIM24 | NA | transcription regulator | NA | 1.00e+00 | 2.0e-02 | Ifi47,Irgm1,LGALS3,TLR2 | NA |
| C5 | NA | cytokine | NA | 1.00e+00 | 3.0e-02 | CCND1,CDH11,CYBB,NFKBIA | NA |
| MAVS | -3.90e-01 | other | NA | 1.00e+00 | 4.0e-02 | CXCL12,IRAK2,MERTK,TNFRSF11B | NA |
| estradiol-17beta-benzoate | NA | chemical reagent | NA | 1.00e+00 | 5.0e-02 | CCND1,GALNT6,SLC2A12,SPSB1,TNFRSF11B | NA |
| hemin | NA | chemical - endogenous mammalian | NA | 1.00e+00 | 1.0e-02 | CCND1,CDKN1A,CYBB,NFYA | NA |
| fulvestrant | NA | chemical drug | NA | 1.00e+00 | 0.0e+00 | CA12,CCND1,CDKN1A,CLK1,CXCL12,ERBB3,FOS,ID2,MYH6,SLC22A12,TNFRSF11B | 79 (22) |
| methyl methanesulfonate | NA | chemical toxicant | NA | 9.80e-01 | 0.0e+00 | CDKN1A,GADD45G,LCN2,NFYA | NA |
| SREBF2 | -8.00e-02 | transcription regulator | NA | 9.80e-01 | 1.0e-02 | CDKN1A,DBI,INSIG1,PTCH1 | NA |
| tanespimycin | NA | chemical drug | NA | 9.70e-01 | 1.0e-02 | AHR,CCND1,CDKN1A,PTCH1,SLC2A1 | 79 (18) |
| PPARGC1A | -1.30e-01 | transcription regulator | NA | 9.60e-01 | 0.0e+00 | APEX2,CDKN1A,FOS,IL1R2,INSIG1,MYH6,NFKBIA,PLIN5,PNPLA2,POSTN,TNFRSF11B | 87 (22) |
| captopril | NA | chemical drug | NA | 9.60e-01 | 0.0e+00 | LCN2,LGALS3,MYH6,POSTN,RBM3,SLC34A2,TGFB3 | 65 (7) |
| NANOG | NA | transcription regulator | NA | 9.50e-01 | 1.0e-02 | AHR,CDKN1A,FOS,ID2,PILRB,TGFB3 | 72 (15) |
| etoposide | NA | chemical drug | NA | 9.40e-01 | 0.0e+00 | CCND1,CDKN1A,GADD45G,ID2,MERTK,SGK1,SLC16A4,SLC2A1,UHRF1 | 97 (21) |
| tetrachlorodibenzodioxin | NA | chemical toxicant | NA | 9.40e-01 | 0.0e+00 | ACER2,ADCY4,AHR,CCND1,CDKN1A,COL13A1,CRYAB,ERBB3,FMO2,FOS,MYH6,Nat8f5,SLC2A1,SLC40A1,Slco1a4,TGFB3 | 86 (20) |
| TP63 | -9.00e-02 | transcription regulator | NA | 9.30e-01 | 0.0e+00 | AEN,AHR,CCND1,CDKN1A,CRYAB,CXCR4,ERBB3,FOS,GRHL2,LCN2,MCM10,NFE2L3,POSTN,POU3F2,RASGRP3,TGFB3,UHRF1,WNT7A | 94 (24) |
| clofibrate | NA | chemical drug | NA | 9.30e-01 | 1.0e-02 | CCND1,EHHADH,Mt1,PEX11A | NA |
| di(2-ethylhexyl) phthalate | NA | chemical toxicant | NA | 9.10e-01 | 0.0e+00 | EHHADH,FOS,IRAK2,PEX11A | 41 (7) |
| PDX1 | NA | transcription regulator | NA | 9.00e-01 | 1.0e-02 | CCND1,CXCR4,ID2,INSIG1,Mt1,SLC2A1 | 75 (17) |
| oleic acid | NA | chemical - endogenous mammalian | NA | 9.00e-01 | 0.0e+00 | CYBB,FOS,LCN2,MLXIPL,Mt1,NCF1,NFKBIA,PLIN4,PLIN5,PNPLA2,TLR2,TLR4 | 64 (17) |
| prostaglandin E2 | NA | chemical - endogenous mammalian | NA | 9.00e-01 | 0.0e+00 | ADAMTS4,AHR,Casp12,CCND1,CCR5,CDKN1A,CLEC12A,CXCL12,CXCR4,ENPP3,FOS,GBP5,IL1R2,NFKBIA,PGF,TNFRSF11B,UHRF1 | 79 (18) |
| RXRA | 7.00e-02 | ligand-dependent nuclear receptor | NA | 8.90e-01 | 0.0e+00 | CCND1,CDKN1A,CRYAB,EHHADH,FOS,GADD45G,GPD1,INSIG1,LCN2,MLXIPL,NFE2L3,RPE65,SFTPB,Slco1a4 | 85 (20) |
| TNFRSF1A | 2.10e-01 | transmembrane receptor | NA | 8.80e-01 | 2.0e-02 | CDKN1A,LCN2,Podxl,Slco1a4,TLR4 | NA |
| tyrphostin AG 1478 | NA | chemical drug | NA | 8.70e-01 | 0.0e+00 | CCND1,CDKN1A,CXCR4,FOS,NCF1,SLC2A1 | 85 (24) |
| CEBPB | 4.60e-01 | transcription regulator | NA | 8.60e-01 | 3.0e-02 | AURKB,CCND1,CCR5,CDKN1A,CSF3R,CXCR4,FOS,LCN2,SGK1,SLC2A1,TLR4 | NA |
| ABCG1 | -3.00e-02 | transporter | NA | 8.50e-01 | 0.0e+00 | CCR5,INSIG1,SLC2A1,TLR4 | 49 (10) |
| EGLN1 | 2.20e-01 | enzyme | NA | 8.50e-01 | 0.0e+00 | CXCR4,SLC2A1,TGFB3,TNFRSF11B | 59 (18) |
| caffeic acid phenethyl ester | NA | chemical drug | NA | 8.50e-01 | 2.0e-02 | CCND1,CDKN1A,NFKBIA,TLR2 | NA |
| trichostatin A | NA | chemical drug | NA | 8.30e-01 | 0.0e+00 | AHR,AURKB,CA12,CA6,CCND1,CDKN1A,CSF3R,CXCL12,CXCR4,CYBB,FOS,GADD45G,GRHL2,ID2,NFKBIA,PNPLA2,SGK1,SLC26A2,SLC2A1,TLR2,TLR4,TNFRSF11B | 84 (18) |
| CDKN1A | 1.85e+00 | kinase | NA | 8.10e-01 | 0.0e+00 | AURKB,CCND1,CDKN1A,CRYAB,GRHL2,ID2,LGALS3,NFKBIA,P4HA1,UHRF1 | 90 (19) |
| APLN | 5.30e-01 | other | NA | 8.10e-01 | 0.0e+00 | CXCR4,FOS,MYH6,NCF1,PTP4A3,TESC | NA |
| PLX5622 | NA | chemical drug | NA | 8.10e-01 | 0.0e+00 | C1QB,CDKN1A,CXCL12,CYBB,CYTH4,LY86,NCF1,TLR2,TLR4,TNFRSF11B | NA |
| Hdac | NA | group | NA | 8.00e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,CXCR4,FOS,NOTCH4,PGF | 84 (22) |
| TCR | NA | complex | NA | 8.00e-01 | 0.0e+00 | CCND1,CCR5,CXCR4,FOS,GADD45G,NFE2L3,NFKBIA,RPL10A,RPL6,SLC2A1,TLR4 | 93 (20) |
| MYC | -3.00e-02 | transcription regulator | NA | 8.00e-01 | 1.0e-02 | AHR,AURKB,CCND1,CDKN1A,CRYAB,CST6,CXCR4,DBI,FKBP5,FOS,GADD45G,ID2,Mt1,MYBPH,NFE2L3,NFKBIA,POU3F2,RIN3,RPL10A,RPL6,SGK1,SLC2A1 | 95 (22) |
| decitabine | NA | chemical drug | NA | 7.90e-01 | 3.0e-02 | CA12,CCND1,CDH11,CDKN1A,CXCL12,CXCR4,GADD45G,LGALS3,NFKBIA,NR0B1,PTCH1,SFTPB,SGK1,WNT7A | NA |
| resveratrol | NA | chemical drug | NA | 7.70e-01 | 1.0e-02 | CCND1,CDKN1A,CYBB,FOS,NFKBIA,PTCH1,TNFRSF11A,TNFRSF11B | 65 (15) |
| IL21 | NA | cytokine | NA | 7.60e-01 | 1.0e-02 | CDKN1A,GBP5,ID2,Irgm1,SGK1,TLR4 | 84 (18) |
| semaxinib | NA | chemical drug | NA | 7.60e-01 | 0.0e+00 | AHR,C1QB,CARD11,CCR5,FOS,IL1R2,LCN2,NFKBIA | 110 (21) |
| FOXA2 | -2.00e-02 | transcription regulator | NA | 7.60e-01 | 0.0e+00 | CCND1,CCR5,CXCR4,MLXIPL,Mt1,SFTPB,SLC10A6,SPSB1,WNT7A | 72 (12) |
| CLU | 1.60e-01 | other | NA | 7.60e-01 | 0.0e+00 | CCND1,CDKN1A,GBP5,NFKBIA | 84 (23) |
| MLXIPL | -6.70e-01 | transcription regulator | NA | 7.60e-01 | 1.0e-02 | GPD1,MLXIPL,PNPLA2,RPL10A,RPL6 | NA |
| APOE | 3.00e-01 | transporter | NA | 7.60e-01 | 0.0e+00 | C1QB,CCND1,CCR5,CYBB,DBI,FKBP5,FOS,LCN2,NCF1,PTP4A3,RPL10A,TLR2 | 101 (19) |
| KLF4 | -3.00e-02 | transcription regulator | NA | 7.60e-01 | 4.0e-02 | CCND1,CDKN1A,CST6,GRHL2,MYH6,NOTCH4,TGFB3 | NA |
| PRKAA2 | -2.10e-01 | kinase | NA | 7.40e-01 | 0.0e+00 | CDKN1A,CXCL12,CYBB,Ifi47,NCF1,NFKBIA | 88 (19) |
| EIF4E | 1.50e-01 | translation regulator | NA | 7.30e-01 | 0.0e+00 | CCND1,CCR5,CDKN1A,CYBB,INSIG1,NFKBIA,PGF,RPL10A | 71 (12) |
| streptozocin | NA | chemical drug | NA | 7.20e-01 | 1.0e-02 | CDKN1A,CXCL12,FOS,LGALS3,MLXIPL,MYH6,NCF1,SLC2A1 | 107 (24) |
| NKX2-3 | NA | transcription regulator | NA | 7.00e-01 | 0.0e+00 | CDKN1A,CRYAB,GALNT15,HELZ2,Podxl,POSTN,RNF213,SLC40A1 | NA |
| camptothecin | NA | chemical drug | NA | 6.90e-01 | 0.0e+00 | AEN,CCND1,CD93,CDKN1A,FOS,GADD45G,INSIG1,LGALS3,MERTK,Mt1,NFKBIA,PIK3C2B,PSTPIP1,SYNJ2,TLR2 | 91 (24) |
| STAT5a/b | NA | group | NA | 6.90e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,FOS,ID2,TLR2 | 87 (25) |
| IL1A | -3.30e-01 | cytokine | NA | 6.90e-01 | 0.0e+00 | ADAMTS4,CDKN1A,CXCL12,FOS,IL1R2,KITLG,LCN2,NFKBIA,TERF2IP,TLR2,TNFRSF11B | 85 (15) |
| SERPINE1 | 1.60e-01 | other | NA | 6.60e-01 | 1.0e-02 | CDKN1A,FOS,NFKBIA,TLR2 | NA |
| carbon tetrachloride | NA | chemical toxicant | NA | 6.60e-01 | 0.0e+00 | CCR5,CDKN1A,CNR2,FOS,GBP5,Mt1,SLC2A1,Slco1a4,SLCO1C1 | 105 (21) |
| SCD | 2.60e-01 | enzyme | NA | 6.60e-01 | 1.0e-02 | ELOVL7,FOS,LCN2,MLXIPL,PNPLA2,SLC2A1 | 82 (21) |
| IL27 | -5.00e-02 | cytokine | NA | 6.60e-01 | 5.0e-02 | AHR,FOS,GADD45G,ID2 | NA |
| MED1 | -2.30e-01 | transcription regulator | NA | 6.50e-01 | 0.0e+00 | AURKB,CCND1,CDKN1A,EHHADH,ID2,NFKBIA,PEX11A | 81 (18) |
| SOCS1 | -1.00e-02 | other | NA | 6.40e-01 | 0.0e+00 | CCND1,CDKN1A,FKBP5,FOS,GBP5,Ifi47 | 87 (23) |
| hydrocortisone | NA | chemical - endogenous mammalian | NA | 6.40e-01 | 0.0e+00 | CCND1,CDH11,CXCR4,Mt1,NFKBIA,NOTCH4,TLR2,TNFRSF11B | 106 (20) |
| MAPK14 | -1.10e-01 | kinase | NA | 6.30e-01 | 0.0e+00 | CCND1,CRYAB,FOS,KITLG,MYH6,RGS1,SGK1,TLR2 | 69 (17) |
| alitretinoin | NA | chemical drug | NA | 6.30e-01 | 0.0e+00 | ADAMTS4,Casp12,CCND1,CDKN1A,DHRS9,FOS,MYH6,SFTPB,TGFB3 | 82 (23) |
| IgG | NA | complex | NA | 6.20e-01 | 0.0e+00 | AHR,CDKN1A,IL1R2,LCN2,LGALS3,NFKBIA,SGK1,SLC40A1,TLR4 | 84 (16) |
| filgrastim | NA | biologic drug | NA | 6.20e-01 | 0.0e+00 | CXCR4,CYBB,DHRS9,FKBP5,GBP5,GPR34,IL1R2,LGALS3,MERTK,RGS1,SGK1,TLR4 | NA |
| IFNB1 | 8.00e-02 | cytokine | NA | 6.00e-01 | 0.0e+00 | CCR5,CDKN1A,CRYAB,FOS,GBP5,Ifi47,Irgm1,MCM10,PHLDB2,PTCH1 | 95 (23) |
| OGT | -2.70e-01 | enzyme | NA | 6.00e-01 | 0.0e+00 | CCND1,CDKN1A,ELOVL7,FOS,POU2F3,PTCH1 | 83 (17) |
| HOXA10 | NA | transcription regulator | NA | 6.00e-01 | 1.0e-02 | CDKN1A,CSF3R,CYBB,DHRS9,ID2,LCN2 | NA |
| U0126 | NA | chemical drug | NA | 5.90e-01 | 0.0e+00 | ADAMTS4,CCND1,CDKN1A,CXCL12,CXCR4,CYBB,FKBP5,FOS,GPR34,IL1R2,NR0B1,PER1,POSTN,SGK1,SLC2A1,TGFB3,TLR2,TNFRSF11B | 101 (19) |
| TNFSF11 | NA | cytokine | NA | 5.80e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,FOS,LCN2,NFKBIA,SLC2A1,TLR2,TLR4,TNFRSF11A,TNFRSF11B | 88 (15) |
| glucocorticoid | NA | chemical drug | NA | 5.80e-01 | 0.0e+00 | AHR,CDKN1A,CXCR4,IL1R2,Mt1,NCF1,NFKBIA,PER1,SFTPB,SGK1,TLR2,TNFRSF11B,ZBTB16 | 88 (21) |
| enalapril | NA | biologic drug | NA | 5.80e-01 | 1.0e-02 | LCN2,LGALS3,SLC34A2,TGFB3 | NA |
| nitric oxide | NA | chemical - endogenous mammalian | NA | 5.70e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,CXCL12,FOS,Mt1,PGF,SGK1,SLC16A4 | 72 (19) |
| BMP2 | -2.00e-01 | growth factor | NA | 5.70e-01 | 0.0e+00 | CCND1,CDKN1A,CXCL12,FOS,ID2,NFYA,POSTN,SLC26A2,TNFRSF11B,ZBTB16 | 84 (23) |
| AHR | -8.40e-01 | ligand-dependent nuclear receptor | NA | 5.70e-01 | 0.0e+00 | C1QB,CARD11,CCND1,CCR5,CDKN1A,COL13A1,CRYAB,FMO2,FOS,IL1R2,Mt1,Nat8f5,SLC2A1,TGFB3 | 95 (26) |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | NA | chemical toxicant | NA | 5.70e-01 | 0.0e+00 | CLK1,CYBB,FKBP5,FOS,NRARP,PLEKHF1,SGK1,SLC40A1,TLR4,ZBTB16 | 65 (14) |
| ERBB2 | 3.00e-02 | kinase | NA | 5.60e-01 | 0.0e+00 | CCND1,CCR5,CDH11,CDKN1A,CHST3,CNR2,CXCL12,CXCR4,EHHADH,ERBB3,FOS,ID2,LCN2,LGALS3,MCM10,NFKBIA,NOTCH4,PER1,SLC2A1 | 81 (22) |
| silibinin | NA | chemical drug | NA | 5.60e-01 | 0.0e+00 | CCND1,CDKN1A,NFKBIA,SLC2A1 | 71 (18) |
| PIK3R1 | 1.00e-01 | kinase | NA | 5.60e-01 | 0.0e+00 | CCND1,CXCL12,ERBB3,FOS,SLC2A1,TGFB3 | 71 (19) |
| EML4-ALK | NA | fusion gene/product | NA | 5.60e-01 | 0.0e+00 | CDKN1A,ERBB3,NR0B1,TGFB3,TLR2 | 45 (9) |
| KAT5 | 3.10e-01 | transcription regulator | NA | 5.60e-01 | 0.0e+00 | CA6,CCND1,CDKN1A,CXCR4,MEX3A,RGS1,WNT7A | 87 (18) |
| IGF1R | -1.60e-01 | transmembrane receptor | NA | 5.60e-01 | 2.0e-02 | CCND1,CD93,CDKN1A,FOS,ID2,RBM3,RPL10A | NA |
| ATF3 | -3.70e-01 | transcription regulator | NA | 5.50e-01 | 5.0e-02 | AURKB,CCND1,CDKN1A,TLR2 | NA |
| SRC | -6.00e-02 | kinase | NA | 5.50e-01 | 0.0e+00 | CCND1,CDKN1A,FOS,POSTN,SLC2A1,TNFRSF11A | 101 (23) |
| FSH | NA | complex | NA | 5.50e-01 | 1.0e-02 | AHR,CCND1,CXCR4,FKBP5,FOS,KITLG,NR0B1,SGK1,SLC2A1,TNFRSF11B | 87 (20) |
| NR4A1 | -2.70e-01 | ligand-dependent nuclear receptor | NA | 5.40e-01 | 0.0e+00 | CCND1,CXCL12,EHHADH,GPD1,KCNIP3,KITLG,Mt1,NFKBIA,TGFB3 | 99 (20) |
| IL10RA | 3.10e-01 | transmembrane receptor | NA | 5.40e-01 | 0.0e+00 | CLEC12A,CSF3R,GBP5,H2-T22,HMCN1,Ifi47,Irgm1,KITLG,LCN2,POSTN,RNF213,SLC2A1,STARD8,TLR2 | 50 (7) |
| 17-alpha-ethinylestradiol | NA | chemical drug | NA | 5.20e-01 | 0.0e+00 | C1QB,CCR5,CDKN1A,FOS,LCN2,LY86,SGK1,SLC34A2,SLC40A1,Slco1a4,SLCO1C1,TGFB3 | 113 (17) |
| NCOA1 | -8.00e-02 | transcription regulator | NA | 5.20e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,ERBB3,FOS,NFKBIA,SFTPB,SLC2A1 | 75 (18) |
| NFATC2 | -3.00e-02 | transcription regulator | NA | 5.10e-01 | 0.0e+00 | CCR5,CDKN1A,CRYAB,HELZ2,MERTK,NFKBIA,POU3F2,RGS1,TLR2 | 102 (20) |
| vancomycin | NA | biologic drug | NA | 5.10e-01 | 0.0e+00 | C1QB,CCND1,Ctla2a,FMO2,FOS,LCN2,LGALS3,RBM3,SLC34A2,TNFRSF11A,USP2 | NA |
| KITLG | -6.40e-01 | growth factor | NA | 5.10e-01 | 0.0e+00 | CDKN1A,CSF3R,CXCL12,CXCR4,FOS,ID2,NFKBIA,Podxl | 83 (22) |
| FAS | -3.00e-01 | transmembrane receptor | NA | 5.00e-01 | 0.0e+00 | CD93,CDKN1A,FOS,GADD45G,LAMP3,LGALS3,MERTK,NFKBIA,PIK3C2B,PSTPIP1,TLR2,TNFRSF11B | 85 (18) |
| BMP7 | -1.40e-01 | growth factor | NA | 5.00e-01 | 2.0e-02 | ADORA1,CDKN1A,CXCR4,ERBB3,ID2,TGFB3 | NA |
| AGER | -4.00e-01 | transmembrane receptor | NA | 4.90e-01 | 2.0e-02 | C1QB,CCND1,CDKN1A,TLR4 | NA |
| GRIN3A | -1.60e-01 | ion channel | NA | 4.50e-01 | 0.0e+00 | HCRTR2,INSIG1,KCNA4,Mt1,RNF152 | NA |
| isobutylmethylxanthine | NA | chemical toxicant | NA | 4.50e-01 | 0.0e+00 | CCND1,CDKN1A,CXCR4,FOS,MERTK,Mt1,SGK1 | 82 (22) |
| RRAS2 | -2.00e-01 | enzyme | NA | 4.50e-01 | 1.0e-02 | ACER2,AHR,PGF,POSTN,RGS1 | NA |
| SYVN1 | 9.00e-02 | transporter | NA | 4.50e-01 | 1.0e-02 | AHR,CCND1,IRAK2,PNPLA2,SLC2A1 | NA |
| mir-802 | NA | microRNA | NA | 4.50e-01 | 1.0e-02 | CDH11,CXCL12,CXCR4,FMO2,TESC | NA |
| MITF | -3.00e-01 | transcription regulator | NA | 4.50e-01 | 4.0e-02 | APEX2,AURKB,CDKN1A,FOS,LGALS3,POU3F2 | NA |
| BHLHE40 | 2.00e-01 | transcription regulator | NA | 4.30e-01 | 0.0e+00 | AHR,CYBB,IL1R2,IRAK2,MERTK,P4HA1,PER1,RGS1,SLC2A1 | 52 (7) |
| anisomycin | NA | chemical - endogenous non-mammalian | NA | 4.20e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,CYBB,FOS,POSTN | 91 (24) |
| Tnf (family) | NA | group | NA | 4.20e-01 | 0.0e+00 | CCND1,CCR5,CXCL12,GJA5,IL1R2,IRAK2,LCN2,NFKBIA,TLR2 | 81 (17) |
| SMAD7 | -4.20e-01 | transcription regulator | NA | 4.20e-01 | 1.0e-02 | CDKN1A,CXCL12,ID2,NFKBIA,TGFB3 | NA |
| PDGF BB | NA | complex | NA | 4.20e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,CRYAB,FOS,GJA5,LGALS3,Mt1,POSTN,PRRX2,RGS1,SGK1,TGFB3,TNFRSF11B | 77 (19) |
| TREM1 | 6.00e-02 | transmembrane receptor | NA | 3.90e-01 | 0.0e+00 | CXCR4,ELOVL7,LAMP3,NFKBIA,RGS1,SYNJ2,TLR2,TLR4 | 73 (7) |
| NR1I3 | -2.00e-02 | ligand-dependent nuclear receptor | NA | 3.90e-01 | 0.0e+00 | AHR,CDKN1A,INSIG1,Mt1,Slco1a4,SLCO1C1 | NA |
| linoleic acid | NA | chemical - endogenous mammalian | NA | 3.90e-01 | 0.0e+00 | MLXIPL,NCF1,NFKBIA,PLIN4,PLIN5 | 59 (14) |
| RASSF1 | 1.20e-01 | other | NA | 3.90e-01 | 0.0e+00 | CCND1,CDKN1A,COL13A1,CXCR4,FOS | 96 (27) |
| SB-431542 | NA | chemical reagent | NA | 3.90e-01 | 0.0e+00 | CCND1,FOS,GPD1,ID2,IL1R2,POSTN,SPSB1 | 102 (24) |
| puromycin aminonucleoside | NA | chemical reagent | NA | 3.80e-01 | 0.0e+00 | Ctla2a,CYBB,LCN2,LGALS3,NCF1,RBM3,SLC34A2 | NA |
| cycloheximide | NA | chemical reagent | NA | 3.70e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,CXCR4,FOS,GADD45G,IL1R2,LCN2,Mt1,NFKBIA,NR0B1,RBM3,SERPINB10,SLC2A1,TNFRSF11B | 78 (18) |
| Z-LLL-CHO | NA | chemical - protease inhibitor | NA | 3.70e-01 | 1.0e-02 | AHR,CCND1,CDKN1A,CRYAB,FOS,MCM10,NCF1,NFKBIA,SFTPB | 83 (24) |
| INS | NA | other | NA | 3.40e-01 | 2.0e-02 | CCND1,CDKN1A,ERBB3,FOS,SLC2A1 | NA |
| wortmannin | NA | chemical drug | NA | 3.40e-01 | 0.0e+00 | CCND1,CDKN1A,ERBB3,FOS,GPD1,NFKBIA,P4HA1,POSTN | 81 (24) |
| fisetin | NA | chemical drug | NA | 3.40e-01 | 0.0e+00 | CCND1,FOS,NFKBIA,TNFRSF11A | 87 (19) |
| PTH | NA | other | NA | 3.30e-01 | 0.0e+00 | CCND1,CDKN1A,CXCL12,CXCR4,FOS,PHLDB2,POSTN,RGS1,TNFRSF11B,WNT7A | 80 (21) |
| cinnamaldehyde | NA | chemical toxicant | NA | 3.20e-01 | 0.0e+00 | FOS,INSIG1,PNPLA2,SLC2A1,SLC2A12,TLR4 | 50 (11) |
| CSF2 | NA | cytokine | NA | 3.20e-01 | 0.0e+00 | CARD11,CCND1,CCR5,CD101,CD180,CDKN1A,CXCR4,CYBB,FIGNL1,FOS,ID2,LAMP3,MFSD2A,NFKBIA,RBM3,SGK1,SLC2A1,TLR2,TLR4,TNFRSF11A,UHRF1 | 107 (19) |
| POU5F1 | NA | transcription regulator | NA | 2.90e-01 | 1.0e-02 | AHR,CCND1,CDKN1A,CST6,CXCL12,GADD45G,NR0B1,TGFB3,TNFRSF11B | NA |
| PP2/AG1879 tyrosine kinase inhibitor | NA | chemical drug | NA | 2.90e-01 | 1.0e-02 | CDKN1A,FOS,NCF1,PER1 | 84 (23) |
| dihydrotestosterone | NA | chemical - endogenous mammalian | NA | 2.90e-01 | 0.0e+00 | CCND1,CDKN1A,CST6,CYBB,DBI,ELOVL7,FKBP5,FOS,GPD1,ID2,KITLG,MCM10,MLXIPL,Mt1,NCF1,NFKBIA,NR0B1,PER1,POSTN,SFTPB,SGK1,SLC2A1,STARD8,WNT7A,ZBTB16 | 115 (24) |
| TWIST1 | -4.70e-01 | transcription regulator | NA | 2.90e-01 | 1.0e-02 | CDKN1A,CXCL12,ENPP3,FOS,LGALS3,PRRX2 | 69 (11) |
| APOA1 | -1.00e-02 | transporter | NA | 2.90e-01 | 0.0e+00 | CYBB,INSIG1,MLXIPL,MYH6,SLC2A1,TLR2,TLR4 | 73 (20) |
| cigarette smoke | NA | chemical toxicant | NA | 2.90e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,FOS,GADD45G,IRAK2,LCN2,NFKBIA,PGF,SLC2A1,TLR4 | 87 (18) |
| doxorubicin | NA | chemical drug | NA | 2.90e-01 | 0.0e+00 | AURKB,CCND1,CDKN1A,Ctla2a,CYBB,FOS,ID2,LCN2,LGALS3,NFKBIA,NIPAL4,Podxl,PTP4A3,RBM3,SLC34A2,TERF2IP,TGFB3,TLR4 | 84 (21) |
| 32-134D | NA | chemical reagent | NA | 2.80e-01 | 0.0e+00 | CXCL12,KITLG,PGF,SLC2A1,TNFRSF11B | NA |
| SPRY2 | -2.50e-01 | other | NA | 2.80e-01 | 0.0e+00 | CDKN1A,CXCR4,FOS,ID2,SFTPB,SLC2A1 | 84 (22) |
| Alpha catenin | NA | group | NA | 2.80e-01 | 1.0e-02 | ADAMTS4,CDH11,CXCL12,NFKBIA,SGK1 | NA |
| RIPK2 | 1.90e-01 | kinase | NA | 2.80e-01 | 1.0e-02 | HELZ2,MAP3K6,NFKBIA,PNPLA2,RASGRP3 | NA |
| Salmonella enterica serotype abortus equi lipopolysaccharide | NA | chemical toxicant | NA | 2.80e-01 | 2.0e-02 | ELOVL7,ID2,LAMP3,RGS1,SYNJ2 | NA |
| acetaminophen | NA | chemical drug | NA | 2.80e-01 | 3.0e-02 | AHR,CCND1,CDKN1A,Mt1,NR0B1,PNPLA2 | NA |
| L-glutamic acid | NA | chemical - endogenous mammalian | NA | 2.70e-01 | 0.0e+00 | CCND1,CDKN1A,FMO2,FOS,INSIG1,PER1 | 84 (23) |
| cobalt chloride | NA | chemical reagent | NA | 2.70e-01 | 0.0e+00 | CDKN1A,CXCR4,HIF3A,RGS1,SLC2A1,SLC40A1 | 59 (16) |
| SOX2 | -3.30e-01 | transcription regulator | NA | 2.60e-01 | 0.0e+00 | ADAMTS4,AHR,CCND1,CDKN1A,CHST3,CST6,CXCL12,CXCR4,FOS,ID2,KITLG,MFSD2A,NIPAL4,NOTCH4,NR0B1,NRARP,SGK2,TGFB3 | 47 (8) |
| ionomycin | NA | chemical reagent | NA | 2.60e-01 | 4.0e-02 | FOS,SGK1,SLC2A1,TLR2,ZBTB16 | NA |
| sodium arsenite | NA | chemical drug | NA | 2.50e-01 | 0.0e+00 | CCND1,CDKN1A,FKBP5,FOS | 103 (24) |
| IGF2 | -1.90e-01 | growth factor | NA | 2.50e-01 | 1.0e-02 | CCND1,CDKN1A,CXCR4,NFKBIA,SFTPB,UHRF1 | 82 (20) |
| KDM1A | 4.00e-02 | enzyme | NA | 2.50e-01 | 0.0e+00 | C1QB,CDKN1A,CYBB,ELOVL7,ENDOU,GALNT15,GBP5,ID2,Irgm1,LY86,NFE2L3,PHLDB2,PLIN4,RASGRP3,RNF213,SIX5,TLR2,TMEM212,UHRF1 | NA |
| DETA-NONOate | NA | chemical reagent | NA | 2.50e-01 | 0.0e+00 | CCND1,CDKN1A,FOS,TNFRSF11B | 85 (19) |
| MET | 1.50e-01 | kinase | NA | 2.40e-01 | 0.0e+00 | AURKB,CCND1,CDKN1A,FOS,MERTK,NOTCH4 | 89 (24) |
| IL10 | NA | cytokine | NA | 2.40e-01 | 0.0e+00 | CA12,CCR5,CDKN1A,CSF3R,CXCL12,CXCR4,FKBP5,FOS,IL1R2,KITLG,LAMP3,MERTK,PLEK,TLR2,TLR4,TNFRSF11A | 96 (20) |
| CG | NA | complex | NA | 2.30e-01 | 0.0e+00 | ADAMTS4,CCND1,CD93,CDKN1A,CRYAB,CXCL12,CXCR4,DBI,ENPP3,FKBP5,FOS,ID2,IL1R2,MCM10,SLC2A1,SLC2A12 | 92 (23) |
| cadmium chloride | NA | chemical toxicant | NA | 2.20e-01 | 0.0e+00 | CCND1,CRYAB,CXCL12,FKBP5,FOS,Mt1,TGFB3 | 86 (25) |
| GPER1 | 2.00e-01 | G-protein coupled receptor | NA | 2.20e-01 | 0.0e+00 | CCND1,CDKN1A,FOS,NFKBIA,SLC2A1 | 97 (25) |
| Brd4 | NA | kinase | NA | 2.20e-01 | 0.0e+00 | ADGRG5,CCR5,LGALS3,LY86,SLC2A1,TLR4 | NA |
| WNT4 | -1.00e-02 | cytokine | NA | 2.20e-01 | 0.0e+00 | CCND1,FKBP5,NR0B1,POSTN | NA |
| conjugated linoleic acid | NA | chemical drug | NA | 2.20e-01 | 0.0e+00 | CCR5,CXCR4,FOS,TNFRSF11B | 89 (20) |
| TNFRSF1B | 1.50e-01 | transmembrane receptor | NA | 2.20e-01 | 2.0e-02 | CCR5,CXCL12,Podxl,TNFRSF11A | NA |
| Nr1h | NA | group | NA | 2.10e-01 | 0.0e+00 | CCR5,ELOVL7,MERTK,MLXIPL,PTCH1,RPE65,TLR4,ZBTB16 | 17 (3) |
| Interferon alpha | NA | group | NA | 2.00e-01 | 0.0e+00 | CCND1,CCR5,CDKN1A,FOS,GBP5,HELZ2,Ifi47,LAMP3,LGALS3,MERTK,NFE2L3,NFKBIA,RGS1,RNF213,TLR2,TLR4 | 90 (20) |
| NR1D1 | 5.00e-02 | ligand-dependent nuclear receptor | NA | 1.90e-01 | 0.0e+00 | EHHADH,FOS,SLC2A1,TLR4 | 37 (7) |
| IL6 | NA | cytokine | NA | 1.90e-01 | 0.0e+00 | ACER2,ADAMTS4,AHR,CCND1,CCR5,CDKN1A,CRYAB,CSF3R,CXCR4,CYBB,FOS,GADD45G,HOMER3,ID2,LCN2,LY86,MERTK,Mt1,Mt1m/Mt2A,NFKBIA,PGF,PLEK,PTP4A3,ROR1,SFTPB,SGK1,SLC40A1,Slco1a4,TLR2,TLR4,TNFRSF11A,TNFRSF11B | 96 (18) |
| CEBPA | 2.60e-01 | transcription regulator | NA | 1.80e-01 | 3.0e-02 | CCND1,CDKN1A,CSF3R,CXCR4,FOS,ID2,LCN2,SFTPB,TNFRSF11A | NA |
| resiquimod | NA | chemical drug | NA | 1.80e-01 | 1.0e-02 | CD180,CXCL12,FOS,IRAK2,LGALS3,NFKBIA,SEMA4B,TLR2,TLR4,TNFRSF11A | 89 (20) |
| IL17A | 0.00e+00 | cytokine | NA | 1.80e-01 | 0.0e+00 | CCND1,CCR5,CXCL12,CXCR4,FOS,LCN2,MERTK,MLXIPL,PGF,SGK1,SLC2A1,SPSB1,TLR2,TLR4,TNFRSF11A,TNFRSF11B | 105 (19) |
| cuprizone | NA | chemical toxicant | NA | 1.70e-01 | 0.0e+00 | ACER2,ASPA,C1QB,CIART,CRYAB,DBI,FOS,GPR34,LGALS3,NCF1 | NA |
| 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene | NA | chemical toxicant | NA | 1.70e-01 | 0.0e+00 | CCND1,CDKN1A,INSIG1,Mt1,PNPLA2,Slco1a4,SLCO1C1 | 8 (2) |
| isoproterenol | NA | chemical drug | NA | 1.70e-01 | 2.0e-02 | FOS,LGALS3,MERTK,PNPLA2,TLR4 | NA |
| OGA | NA | enzyme | NA | 1.70e-01 | 0.0e+00 | C1QB,CCND1,CCR5,CD93,CDKN1A,ERBB3,FZD10,GADD45G,GALNT6,GPR34,IP6K3,TNFRSF11B | 52 (7) |
| NfkB1-RelA | NA | complex | NA | 1.50e-01 | 0.0e+00 | ADAMTS4,CCND1,LCN2,TNFRSF11B | NA |
| MMP1 | NA | peptidase | NA | 1.50e-01 | 0.0e+00 | CDKN1A,CXCL12,FOS,NFKBIA | 86 (19) |
| ERBB4 | 2.00e-01 | kinase | NA | 1.50e-01 | 0.0e+00 | CCND1,CDKN1A,CXCL12,SLC2A1,WNT7A | 105 (22) |
| BMP10 | -6.00e-02 | growth factor | NA | 1.50e-01 | 1.0e-02 | FOS,ID2,LCN2,NFKBIA | NA |
| HAVCR1 | NA | other | NA | 1.50e-01 | 2.0e-02 | AHR,IL1R2,NFKBIA,SLC16A4 | NA |
| N-[N-(3,5-difluorophenacetyl-L-Ala)]-S-phenylglycine t-butyl ester | NA | chemical - protease inhibitor | NA | 1.50e-01 | 2.0e-02 | CXCL12,CXCR4,SGK1,TLR4 | NA |
| CD28 | 1.50e-01 | transmembrane receptor | NA | 1.50e-01 | 1.0e-02 | AHR,CCND1,CCR5,CLK1,CXCR4,FOS,NFKBIA,RPL6,TNFRSF11A | 81 (21) |
| SMARCB1 | NA | transcription regulator | NA | 1.40e-01 | 0.0e+00 | CCND1,CDKN1A,CXCR4,DOCK8,FOS,MCM10,POSTN | 103 (21) |
| EWSR1-FLI1 | NA | fusion gene/product | NA | 1.30e-01 | 1.0e-02 | CCND1,CDKN1A,POSTN,SH3D19 | NA |
| NR1I2 | 1.50e-01 | ligand-dependent nuclear receptor | NA | 1.30e-01 | 0.0e+00 | AHR,CDKN1A,INSIG1,LCN2,Slco1a4,SLCO1C1,TNFRSF11B | 88 (13) |
| trinitrobenzenesulfonic acid | NA | chemical reagent | NA | 1.30e-01 | 0.0e+00 | CCR5,FOS,IL1R2,LCN2,Slco1a4 | NA |
| RARB | -1.10e-01 | ligand-dependent nuclear receptor | NA | 1.30e-01 | 1.0e-02 | CDKN1A,CRYAB,CXCL12,Ifi47,Irgm1,SLC2A1 | 44 (7) |
| CHUK | -2.10e-01 | kinase | NA | 1.20e-01 | 0.0e+00 | CCND1,CDKN1A,CXCL12,FOS,LCN2,Mt1,NFKBIA,SGK1,TERF2IP,TNFRSF11B | 87 (16) |
| ATF4 | 3.00e-01 | transcription regulator | NA | 1.20e-01 | 1.0e-02 | CDKN1A,LAMP3,LGALS3,PRRX2,TNFRSF11A,TNFRSF11B | NA |
| IKBKG | -1.60e-01 | kinase | NA | 1.10e-01 | 0.0e+00 | CXCL12,FOS,LCN2,Mt1,MYH6,NFKBIA,SGK1 | 82 (21) |
| actinomycin D | NA | biologic drug | NA | 1.10e-01 | 0.0e+00 | CCND1,CDKN1A,FOS,ID2,IL1R2,Mt1,NR0B1,SLC2A1,SLC40A1,TLR2 | 91 (23) |
| nitrofurantoin | NA | chemical drug | NA | 1.10e-01 | 0.0e+00 | CCND1,DBI,EHHADH,LGALS3,Mt1,NFKBIA,RPL6,SLC34A2 | NA |
| CCN1 | NA | other | NA | 1.10e-01 | 1.0e-02 | CCND1,CDKN1A,TLR4,WNT7A | 84 (24) |
| SIRT1 | 1.30e-01 | transcription regulator | NA | 1.00e-01 | 0.0e+00 | AURKB,CA12,CCND1,CDKN1A,HCRTR2,HELZ2,Ifi47,Irgm1,LGALS3,NCF1,PER1,RNF213,RPL10A,SLC2A1 | 81 (19) |
| SATB1 | -1.20e-01 | transcription regulator | NA | 1.00e-01 | 0.0e+00 | CCND1,CDKN1A,CSF3R,CYBB,HELZ2,IL1R2,KITLG,RGS1,SGK1,UHRF1 | NA |
| TSH | NA | complex | NA | 1.00e-01 | 0.0e+00 | CCND1,CDKN1A,FOS,Mt1,SLC2A1 | 94 (25) |
| MTOR | -8.00e-02 | kinase | NA | 9.00e-02 | 1.0e-02 | CCND1,CDKN1A,CXCR4,FOS,ISLR2,MLXIPL,SLC2A1,TLR4,TNFRSF11B | 99 (20) |
| 4-hydroxytamoxifen | NA | chemical drug | NA | 8.00e-02 | 1.0e-02 | CCND1,CDKN1A,FOS,NFKBIA,SGK1,SLC2A1 | 84 (23) |
| calphostin C | NA | chemical drug | NA | 6.00e-02 | 0.0e+00 | CCND1,CDKN1A,FOS,SLC2A1 | 73 (24) |
| diethylnitrosamine | NA | chemical toxicant | NA | 5.00e-02 | 0.0e+00 | AURKB,CCND1,CDKN1A,CXCL12,LCN2,Mt1 | 105 (24) |
| OSM | 1.00e-02 | cytokine | NA | 5.00e-02 | 0.0e+00 | ADAMTS4,AHR,CA6,CCND1,CDKN1A,CST6,CXCL12,ERBB3,FOS,GADD45G,ID2,IL1R2,LCN2,PGF,TLR2,TNFRSF11A,TNFRSF11B | 103 (19) |
| TLR4 | -6.50e-01 | transmembrane receptor | NA | 4.00e-02 | 0.0e+00 | CCR5,FOS,GADD45G,GPR34,HELZ2,Ifi47,Irgm1,LCN2,MERTK,NFKBIA,PLEK,RGS1,SLC2A1,TLR2,TLR4 | 104 (17) |
| IL7 | -1.00e-01 | cytokine | NA | 4.00e-02 | 5.0e-02 | AHR,CDKN1A,CXCR4,SLC2A1 | NA |
| NFKBIA | 7.30e-01 | transcription regulator | NA | 4.00e-02 | 0.0e+00 | AURKB,CCND1,CDKN1A,CRYAB,CXCL12,CXCR4,FOS,GADD45G,LCN2,MEX3A,Mt1,NFKBIA,SGK1,TLR2,TLR4,TNFRSF11B | 81 (17) |
| WT1 | 1.00e-02 | transcription regulator | NA | 4.00e-02 | 4.0e-02 | CCND1,CDKN1A,LGALS3,Podxl,SLC2A1,TGFB3 | NA |
| L-triiodothyronine | NA | chemical - endogenous mammalian | NA | 2.00e-02 | 0.0e+00 | CCND1,CDKN1A,CXCL12,EHHADH,FOS,H2-T22,ID2,LCN2,LGALS3,MLXIPL,MYBPH,MYH6,NR0B1,PER1,SLC2A1,SLCO1C1,WNT7A | 91 (24) |
| CEBPD | 4.90e-01 | transcription regulator | NA | 1.00e-02 | 0.0e+00 | CCND1,CDKN1A,CSF3R,CXCR4,FOS,SLC2A1 | 87 (19) |
| palmitic acid | NA | chemical - endogenous mammalian | NA | 0.00e+00 | 0.0e+00 | AHR,Casp12,CDKN1A,CYBB,FOS,IRAK2,LCN2,MLXIPL,Mt1,NCF1,NFKBIA,PNPLA2,SLC40A1,TLR2,TLR4 | 82 (18) |
| THZ2 | NA | chemical drug | NA | 0.00e+00 | 0.0e+00 | CCND1,CDKN1A,IRAK2,SLC2A1 | 48 (4) |
| NRAS | -3.00e-02 | enzyme | NA | 0.00e+00 | 0.0e+00 | CCND1,CDKN1A,CYBB,HOMER3,Irgm1,LCN2,LY86,PTP4A3,SLC2A1 | 98 (22) |
| TFRC | -1.30e-01 | transporter | NA | 0.00e+00 | 0.0e+00 | CDKN1A,FOS,ID2,RGS1,SLC2A1,TGFB3 | 37 (7) |
| ZC3H12A | -4.00e-02 | enzyme | NA | 0.00e+00 | 0.0e+00 | FOS,GBP5,IL1R2,LCN2,LFNG,NCF1,PLEK,SEMA4B | 56 (7) |
| ADGRE2 | NA | other | NA | 0.00e+00 | 0.0e+00 | CCND1,CDKN1A,FOS,TLR4 | 43 (7) |
| siponimod | NA | chemical drug | NA | 0.00e+00 | 0.0e+00 | ACER2,CIART,GPR34,NCF1 | NA |
| etanercept | NA | biologic drug | NA | 0.00e+00 | 0.0e+00 | CXCL12,CYBB,NCF1,Slco1a4 | 72 (7) |
| colistin | NA | biologic drug | NA | 0.00e+00 | 0.0e+00 | C1QB,CCND1,FOS,LGALS3,TNFRSF11A,USP2 | NA |
| NFE2L2 | -6.00e-02 | transcription regulator | NA | 0.00e+00 | 0.0e+00 | AHR,CDKN1A,CHORDC1,CYBB,FKBP5,GADD45G,IL1R2,Mt1,NCF1,NFE2L3,NR0B1,PTCH1,RUNX1T1,SLC2A1 | 66 (10) |
| kanamycin A | NA | chemical drug | NA | 0.00e+00 | 0.0e+00 | C1QB,CCND1,FOS,LGALS3,TNFRSF11A,USP2 | NA |
| metronidazole | NA | chemical drug | NA | 0.00e+00 | 0.0e+00 | C1QB,CCND1,FOS,LGALS3,TNFRSF11A,USP2 | 32 (7) |
| PSMB11 | 1.00e-01 | peptidase | NA | 0.00e+00 | 0.0e+00 | CCND1,CXCL12,LGALS3,NCF1,PLCB2,TNFRSF11A | NA |
| EGR2 | -9.00e-02 | transcription regulator | NA | 0.00e+00 | 0.0e+00 | AHR,CDKN1A,FOS,ID2,IL1R2,KITLG,POU3F2,TGFB3,ZBTB16 | 100 (25) |
| TGFB2 | 1.20e-01 | growth factor | NA | 0.00e+00 | 0.0e+00 | AHR,CDH11,FOS,RUNX1T1,TNFRSF11B | 98 (17) |
| FGF7 | 1.20e-01 | growth factor | NA | 0.00e+00 | 1.0e-02 | CCND1,CDKN1A,NFE2L3,SFTPB | 87 (26) |
| methotrexate | NA | chemical drug | NA | 0.00e+00 | 1.0e-02 | C1QB,CCND1,CDKN1A,CXCL12,EHHADH,Mt1,TNFRSF11B | 85 (18) |
| Irgm1 | -6.90e-01 | other | NA | 0.00e+00 | 1.0e-02 | AURKB,GBP5,ID2,TLR2 | NA |
| TNFSF12 | 1.00e-01 | cytokine | NA | 0.00e+00 | 2.0e-02 | CCND1,CCR5,IL1R2,NFKBIA | NA |
| gentamicin | NA | chemical drug | NA | 0.00e+00 | 2.0e-02 | C1QB,CCND1,CHORDC1,FOS,LCN2,LGALS3,TNFRSF11A,USP2 | NA |
| CCN2 | NA | growth factor | NA | 0.00e+00 | 2.0e-02 | ADAMTS4,CCND1,KITLG,P4HA1 | NA |
| phytohemagglutinin | NA | chemical drug | NA | 0.00e+00 | 2.0e-02 | CDH11,CXCL12,CXCR4,FOS,GPD1,IL1R2,PGF | NA |
| CDK19 | -1.60e-01 | kinase | NA | 0.00e+00 | 3.0e-02 | AEN,CDKN1A,NR0B1,Podxl | NA |
| NR0B2 | 1.10e-01 | ligand-dependent nuclear receptor | NA | 0.00e+00 | 3.0e-02 | CARD11,CDKN1A,TLR2,TNFRSF11A | NA |
| IRF8 | -4.70e-01 | transcription regulator | NA | 0.00e+00 | 4.0e-02 | CDKN1A,CSF3R,CYBB,FOS,TLR4 | NA |
| butyric acid | NA | chemical - endogenous mammalian | NA | -2.00e-02 | 0.0e+00 | CCND1,CCR5,CDH11,CDKN1A,CXCR4,FOS,NFKBIA,PLCB2,SGK1,SLC26A2,SLC2A1,TLR2 | 70 (19) |
| iron | NA | chemical - endogenous mammalian | NA | -2.00e-02 | 0.0e+00 | CCND1,CDKN1A,GADD45G,LCN2,Mt1,NFYA,SLC40A1 | 91 (21) |
| vasoactive intestinal peptide | NA | biologic drug | NA | -3.00e-02 | 0.0e+00 | FOS,KITLG,TLR4,TNFRSF11B | NA |
| GPS2 | 2.80e-01 | transcription regulator | NA | -3.00e-02 | 0.0e+00 | CCND1,CDKN1A,NFKBIA,PLA2G3,SGK1 | 80 (21) |
| Immunoglobulin | NA | complex | NA | -3.00e-02 | 0.0e+00 | ADCY4,AHR,C1QB,CCND1,CD93,CXCL12,CXCR4,DBI,ENPP3,FKBP5,FOS,GBP5,GPR34,HELZ2,IL1R2,LCN2,LGALS3,MERTK,MFSD2A,NFKBIA,PLA2G3,PLEK,PLIN4,PNPLA2,POSTN,SEMA4B,SLC2A1,TLR2,TNFRSF11A,TNFRSF11B,ZBTB16 | 84 (18) |
| lipopolysaccharide | NA | chemical drug | NA | -4.00e-02 | 0.0e+00 | ADAMTS4,ADORA1,AEN,AHR,AURKB,CARD11,Casp12,CCND1,CCR5,CD180,CDH11,CDKN1A,CHST3,CNR2,CRYAB,CSF3R,CXCL12,CXCR4,CYBB,DOCK8,EHHADH,FOS,GADD45G,GBP5,GJA5,GPD1,GPR34,ID2,Ifi47,IL1R2,INSIG1,IRAK2,Irgm1,KITLG,LAMP3,LCN2,LGALS3,LY86,MAP3K6,MCM10,MERTK,Mt1,NCF1,NFKBIA,NOTCH4,NRARP,P4HA1,PHLDB2,PIK3AP1,PLEK,PLIN4,Podxl,PRR5,PTCH1,RASGRP3,RGS1,RNF213,SFTPB,SLC2A1,SLC40A1,Slco1a4,TLR2,TLR4,TNFRSF11A,UHRF1,ZBTB16 | 115 (21) |
| ZFP36 | 3.70e-01 | transcription regulator | NA | -5.00e-02 | 0.0e+00 | CDKN1A,CYBB,FOS,LCN2,NFKBIA,TLR4 | 92 (20) |
| capsaicin | NA | chemical drug | NA | -6.00e-02 | 0.0e+00 | CCND1,FOS,KCNA4,KITLG,SGK1,TNFRSF11B | 90 (20) |
| CCL5 | 3.20e-01 | cytokine | NA | -7.00e-02 | 0.0e+00 | AHR,CCR5,FOS,SGK1,TLR4 | 88 (20) |
| CDKN2A | NA | transcription regulator | NA | -7.00e-02 | 0.0e+00 | AURKB,CCND1,CDKN1A,FOS,GADD45G,IL1R2,KITLG,LGALS3,PGF,TGFB3,TLR4,ZBTB16 | 118 (23) |
| hydrogen peroxide | NA | chemical - endogenous mammalian | NA | -8.00e-02 | 0.0e+00 | AEN,BANP,CCND1,CCR5,CDKN1A,CRYAB,CSF3R,CXCR4,FOS,INSIG1,KITLG,LCN2,PGF,SFTPB,SGK1,TLR4,UHRF1 | 89 (20) |
| bisindolylmaleimide I | NA | chemical drug | NA | -9.00e-02 | 0.0e+00 | CDKN1A,FOS,Mt1,MYH6,NFKBIA,TGFB3 | 82 (23) |
| CD3 | NA | complex | NA | -9.00e-02 | 0.0e+00 | AHR,CCND1,CCR5,CLK1,CXCR4,FOS,HMCN1,NFKBIA,PLEK,RBM3,RPL6,SERPINB10,TLR2,TNFRSF11A | 99 (18) |
| Mapk | NA | group | NA | -9.00e-02 | 0.0e+00 | CCND1,CDKN1A,CYBB,FOS,PER1 | 88 (24) |
| IRF1 | -2.00e-01 | transcription regulator | NA | -9.00e-02 | 5.0e-02 | CCND1,CDKN1A,CYBB,HELZ2,Ifi47 | NA |
| WNT5A | -4.80e-01 | cytokine | NA | -1.00e-01 | 0.0e+00 | CCND1,CRYAB,CXCL12,CXCR4,ID2,PGF,POSTN,RPE65,TLR4,TNFRSF11A | 123 (22) |
| testosterone | NA | chemical - endogenous mammalian | NA | -1.00e-01 | 0.0e+00 | CCND1,CDKN1A,ERBB3,FOS,HCRTR2,Mt1,NFKBIA,PTCH1,TLR4,TNFRSF11B | 78 (19) |
| PPP5C | 3.10e-01 | phosphatase | NA | -1.10e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,SGK1 | 81 (22) |
| MAP2K1 | 9.00e-02 | kinase | NA | -1.10e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,CRYAB,FOS,LGALS3,NFKBIA,TNFRSF11A | 101 (20) |
| NFAT5 | -2.20e-01 | transcription regulator | NA | -1.30e-01 | 0.0e+00 | CYBB,Irgm1,LCN2,NFKBIA,SGK1,TLR2,TNFRSF11B | 53 (10) |
| mir-182 | NA | microRNA | NA | -1.30e-01 | 0.0e+00 | CARD11,CXCL12,GADD45G,PGF,TLR4 | NA |
| adavosertib | NA | chemical drug | NA | -1.30e-01 | 1.0e-02 | CXCL12,IRAK2,MERTK,TNFRSF11B | NA |
| CD40 | -1.10e-01 | transmembrane receptor | NA | -1.40e-01 | 0.0e+00 | CCND1,CDKN1A,CNR2,CXCL12,FOS,LGALS3,MAP3K6,NFKBIA,SLC2A1,TLR2,TNFRSF11B,ZBTB16 | 81 (15) |
| TGFA | 2.20e-01 | growth factor | NA | -1.40e-01 | 1.0e-02 | CCND1,CDKN1A,FOS,LCN2 | 102 (24) |
| norepinephrine | NA | chemical - endogenous mammalian | NA | -1.50e-01 | 0.0e+00 | CXCR4,FOS,GPD1,IRAK2,NFKBIA,PER1,PTCH1,SGK1,SLC2A1 | 81 (22) |
| THRB | -5.00e-02 | ligand-dependent nuclear receptor | NA | -1.50e-01 | 0.0e+00 | CCND1,CXCR4,EHHADH,ERBB3,FOS,FZD9,GJA5,MLXIPL,MYH6,NCF1,PER1,TLR2,WNT7A | 88 (20) |
| caspase | NA | group | NA | -1.50e-01 | 0.0e+00 | ACER2,CCND1,CDKN1A,NCF1 | 66 (17) |
| HIC1 | -4.00e-01 | transcription regulator | NA | -1.50e-01 | 0.0e+00 | CA12,CCND1,CDKN1A,LCN2 | 59 (11) |
| miR-204-5p (and other miRNAs w/seed UCCCUUU) | NA | mature microRNA | NA | -1.50e-01 | 0.0e+00 | AURKB,CDH11,ID2,TGFB3 | NA |
| IL6R | 5.40e-01 | transmembrane receptor | NA | -1.50e-01 | 1.0e-02 | CDKN1A,LCN2,TNFRSF11A,TNFRSF11B | 84 (20) |
| DUSP1 | 8.00e-02 | phosphatase | NA | -1.50e-01 | 1.0e-02 | CYBB,HELZ2,MERTK,PEX11A,TLR2 | NA |
| CYP1B1 | -1.60e-01 | enzyme | NA | -1.50e-01 | 3.0e-02 | CCND1,INSC,Mt1,TGFB3 | NA |
| SLC15A4 | -2.50e-01 | transporter | NA | -1.50e-01 | 4.0e-02 | FOS,GBP5,LGALS3,RGS1 | NA |
| CXCL12 | -6.50e-01 | cytokine | NA | -1.60e-01 | 0.0e+00 | CCND1,CXCL12,CXCR4,FOS,Podxl,TNFRSF11A,TNFRSF11B,ZBTB16 | 72 (19) |
| Akt | NA | group | NA | -1.80e-01 | 0.0e+00 | CCND1,CDKN1A,CHST3,CXCL12,CXCR4,ERBB3,FKBP5,FOS,HIF3A,LCN2,MLXIPL,NFKBIA,RPL6,SGK1,SLC2A1,TLR2,TNFRSF11A | 75 (18) |
| E. coli B4 lipopolysaccharide | NA | chemical toxicant | NA | -1.80e-01 | 0.0e+00 | C1QB,CYTH4,GADD45G,LCN2,NCF1,NFKBIA,PLEK,TLR2,TLR4,UHRF1 | 86 (18) |
| NFKB1 | -1.40e-01 | transcription regulator | NA | -1.80e-01 | 1.0e-02 | ADORA1,CCND1,CDKN1A,CYBB,FOS,NFKBIA,RGS1,TLR2 | 88 (14) |
| IKBKB | -1.10e-01 | kinase | NA | -1.80e-01 | 0.0e+00 | AURKB,CCND1,CDKN1A,CXCL12,CXCR4,FOS,LCN2,Mt1,NFKBIA,POSTN,SGK1,TERF2IP,TNFRSF11B | 64 (17) |
| PSEN1 | -3.40e-01 | peptidase | NA | -1.90e-01 | 0.0e+00 | C1QB,Casp12,CCND1,CCR5,DBI,FOS,H2BC5,LFNG,MCM10,MERTK,PSTPIP1,RBM3 | 63 (8) |
| Pka | NA | complex | NA | -1.90e-01 | 0.0e+00 | CDKN1A,FOS,NCF1,SFTPB,SGK1,TNFRSF11B | 83 (21) |
| HMGB1 | NA | transcription regulator | NA | -1.90e-01 | 1.0e-02 | CDKN1A,MERTK,TLR2,TLR4 | NA |
| GDF2 | 7.00e-02 | growth factor | NA | -2.00e-01 | 0.0e+00 | CDH11,CRYAB,CXCL12,CXCR4,FOS,ID2,NFKBIA,POSTN,SHISA3,SLC40A1,TLR4 | 67 (14) |
| JAG1 | -5.60e-01 | growth factor | NA | -2.00e-01 | 0.0e+00 | CCND1,CDKN1A,ERBB3,NOTCH4,TGFB3 | 84 (19) |
| RELA | 2.10e-01 | transcription regulator | NA | -2.00e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,CRYAB,CXCR4,CYBB,DOCK8,FOS,NFKBIA,RGS1,TERF2IP,TLR2,TNFRSF11B | 86 (20) |
| CSF1 | -1.80e-01 | cytokine | NA | -2.00e-01 | 0.0e+00 | CCND1,CCR5,CDKN1A,CYBB,FOS,GPR34,ID2,MERTK,SLC2A1,TLR2,TNFRSF11A | 110 (19) |
| dextran sulfate | NA | chemical drug | NA | -2.20e-01 | 0.0e+00 | AHR,CARD11,CCND1,CDKN1A,FIGNL1,FZD10,PGF,PTP4A3,SLC2A1,TGFB3,TLR4,UHRF1 | 91 (19) |
| prostaglandin D2 | NA | chemical - endogenous mammalian | NA | -2.20e-01 | 0.0e+00 | AHR,CCND1,ENPP3,TNFRSF11B | 68 (14) |
| DNMT3B | 4.00e-02 | enzyme | NA | -2.20e-01 | 3.0e-02 | ADORA1,CDKN1A,MYH6,PIK3C2B,RPL10A | NA |
| HGF | -5.00e-02 | growth factor | NA | -2.20e-01 | 0.0e+00 | AHR,AURKB,CCND1,CD93,CDKN1A,CRYAB,CXCR4,FKBP5,FOS,INSIG1,KITLG,LCN2,MERTK,PGF,SGK1 | 77 (16) |
| sirolimus | NA | chemical drug | NA | -2.20e-01 | 0.0e+00 | AURKB,CCND1,CCR5,CDKN1A,CXCR4,ERBB3,FOS,GPD1,ID2,LCN2,LGALS3,Mt1,MYH6,POSTN,RPL10A,RPL6,SLC2A1,TNFRSF11B | 91 (20) |
| VHL | 0.00e+00 | transcription regulator | NA | -2.40e-01 | 0.0e+00 | CA12,CCND1,CDKN1A,CXCL12,CXCR4,SLC2A1,SLC40A1 | 69 (21) |
| LY294002 | NA | chemical drug | NA | -2.40e-01 | 0.0e+00 | CCND1,CDKN1A,ERBB3,FOS,GPD1,IL1R2,LCN2,NFKBIA,POSTN,RGS1,SGK1,SLC2A1,TLR2,WNT7A,ZBTB16 | 84 (21) |
| PRKAA1 | -1.60e-01 | kinase | NA | -2.40e-01 | 0.0e+00 | CDKN1A,CXCL12,FKBP5,ID2,Ifi47,NCF1,NFKBIA,SLC2A1 | 96 (21) |
| TO-901317 | NA | chemical reagent | NA | -2.40e-01 | 0.0e+00 | Casp12,CCND1,EHHADH,GPD1,LGALS3,MLXIPL,Mt1,NFKBIA,TLR4 | 67 (18) |
| TGM2 | -1.00e-02 | enzyme | NA | -2.40e-01 | 1.0e-02 | CCND1,CD101,CD93,CXCL12,MERTK,RNF213,TNFRSF11B | 62 (10) |
| Creb | NA | group | NA | -2.50e-01 | 1.0e-02 | CCND1,CDKN1A,FOS,GJA5,PER1,PRLHR,SLC2A1,Slco1a4,TNFRSF11B | 77 (19) |
| PRKCD | -4.30e-01 | kinase | NA | -2.50e-01 | 0.0e+00 | CCND1,CDKN1A,CXCL12,FOS,GRHL2,MAST4,NFKBIA,PTCH1,TLR2,TNFRSF11B | 73 (15) |
| FN1 | -2.00e-02 | enzyme | NA | -2.80e-01 | 1.0e-02 | CCND1,CDKN1A,FOS,NFKBIA,SLC2A1,TLR2 | NA |
| FGF1 | -1.60e-01 | growth factor | NA | -2.80e-01 | 0.0e+00 | AHR,CCND1,CDH11,CDKN1A,FOS,GADD45G,Irgm1,POSTN,TGFB3 | 88 (23) |
| FGF2 | 5.00e-01 | growth factor | NA | -2.80e-01 | 0.0e+00 | ACER2,CCND1,CDH11,CDKN1A,CRYAB,CXCL12,CXCR4,FOS,ID2,NOTCH4,PGF,Podxl,SLC2A1 | 74 (20) |
| erlotinib | NA | chemical drug | NA | -2.80e-01 | 0.0e+00 | CYBB,NFKBIA,TLR2,TLR4,TNFRSF11B | 94 (15) |
| thyroid hormone | NA | chemical - endogenous mammalian | NA | -2.80e-01 | 1.0e-02 | CCND1,CDKN1A,DBI,FOS,MYH6,PER1 | 78 (22) |
| SOX9 | -2.00e-01 | transcription regulator | NA | -2.90e-01 | 1.0e-02 | CDKN1A,CXCR4,FOS,FZD9,POSTN | 101 (24) |
| tacrolimus | NA | chemical drug | NA | -2.90e-01 | 0.0e+00 | CCND1,CXCR4,CYBB,FKBP5,FOS,IL1R2,NFKBIA,WNT7A | 75 (19) |
| FOS | -6.40e-01 | transcription regulator | NA | -3.00e-01 | 1.0e-02 | CCND1,CDH11,Fhod1,FOS,KITLG,LGALS3,MYH6,NOTCH4,TNFRSF11A,TNFRSF11B,Trib2,WNT7A | 71 (11) |
| STAT4 | NA | transcription regulator | NA | -3.00e-01 | 2.0e-02 | BANP,CCR5,GADD45G,Mt1,PER1,TGFB3 | NA |
| VIP | 3.70e-01 | other | NA | -3.10e-01 | 0.0e+00 | CCND1,FOS,IRAK2,NFKBIA,TLR4,TNFRSF11A | 94 (22) |
| Pkc(s) | NA | group | NA | -3.20e-01 | 0.0e+00 | AHR,CCR5,CDKN1A,CXCR4,CYBB,FOS,ID2,NOTCH4,PER1,TNFRSF11A | 96 (21) |
| SMARCA5 | 0.00e+00 | transcription regulator | NA | -3.30e-01 | 0.0e+00 | AEN,AHR,CD93,CDKN1A,CLEC12A,FKBP5,H2-T22,LFNG,MAST4 | NA |
| 2-deoxyglucose | NA | chemical drug | NA | -3.30e-01 | 1.0e-02 | CCND1,CDKN1A,FOS,SLC2A1 | NA |
| glycine | NA | chemical - endogenous mammalian | NA | -3.40e-01 | 0.0e+00 | CCND1,CDKN1A,FOS,TLR4 | 80 (23) |
| zoledronic acid | NA | chemical drug | NA | -3.40e-01 | 0.0e+00 | CXCR4,TLR4,TNFRSF11A,TNFRSF11B | 98 (20) |
| ACVRL1 | -2.30e-01 | kinase | NA | -3.40e-01 | 0.0e+00 | CDKN1A,CXCL12,CXCR4,ID2,TLR4 | 37 (7) |
| CRH | 3.90e-01 | cytokine | NA | -3.40e-01 | 0.0e+00 | FOS,SGK1,SLC2A1,TLR4 | 81 (21) |
| tunicamycin | NA | chemical - endogenous non-mammalian | NA | -3.50e-01 | 0.0e+00 | CA6,Casp12,CCND1,CDKN1A,ERBB3,MFSD2A,MLXIPL,NFKBIA,SLC2A1,TLR2 | 93 (19) |
| MAPK1 | 2.00e-02 | kinase | NA | -3.50e-01 | 1.0e-02 | CCND1,CDKN1A,FOS,GBP5,LAMP3,LGALS3,POSTN,RPE65,SPSB1 | NA |
| BCL3 | 2.90e-01 | transcription regulator | NA | -3.70e-01 | 0.0e+00 | CCND1,FOS,ID2,NFKBIA | 94 (25) |
| BCR (complex) | NA | complex | NA | -3.80e-01 | 0.0e+00 | CCND1,CDKN1A,CXCR4,FOS,IL1R2,LFNG,PLEK,SEMA4B,SLC2A1,ZBTB16 | 80 (18) |
| SNCA | 3.50e-01 | enzyme | NA | -3.80e-01 | 0.0e+00 | CA12,CXCR4,CYBB,GBP5,Ifi47,NCF1,RPRML,RSPO2,SYNJ2,TLR2,TLR4 | 98 (18) |
| IRF4 | -1.10e-01 | transcription regulator | NA | -3.80e-01 | 0.0e+00 | CXCR4,DBI,DOCK8,ERBB3,RGS1,RPL6,SLC2A1 | NA |
| CCND1 | -8.80e-01 | transcription regulator | NA | -3.80e-01 | 1.0e-02 | CCND1,CDKN1A,ELOVL7,Klra2,MCM10,TGFB3,UHRF1,WNT7A | NA |
| RAF1 | 0.00e+00 | kinase | NA | -3.80e-01 | 0.0e+00 | CCND1,CDKN1A,CLK1,CRYAB,FOS,RGS1,SLC26A2 | 85 (22) |
| diethylstilbestrol | NA | chemical drug | NA | -3.80e-01 | 0.0e+00 | AHR,AURKB,CCND1,CDKN1A,ENDOU,FOS,IL1R2,Slco1a4,TGFB3,WNT7A | 98 (22) |
| TGFB1 | -2.10e-01 | growth factor | NA | -3.90e-01 | 0.0e+00 | ADAMTS4,ADORA1,AHR,C1QB,CCND1,CCR5,CD101,CDH11,CDKN1A,CHST3,CXCL12,CXCR4,CYBB,FOS,GPD1,GRHL2,ID2,INSIG1,IRAK2,KITLG,LCN2,LGALS3,MLXIPL,NCF1,NFKBIA,P4HA1,POSTN,PTP4A3,RASGRP3,RBM3,RNF152,ROR1,SERPINB10,SFTPB,SGK1,SHISA3,SLC19A3,SLC2A1,TGFB3,TLR2,TLR4,TNFRSF11A,TNFRSF11B,WNT7A | 108 (19) |
| SPP1 | -1.60e-01 | cytokine | NA | -3.90e-01 | 4.0e-02 | CCND1,CDKN1A,CXCL12,FOS,INSIG1 | NA |
| ADRB | NA | group | NA | -4.00e-01 | 0.0e+00 | ADAMTS4,ADCY4,CCND1,CDKN1A,CRYAB,FOS,INSIG1,NFKBIA,SLC40A1 | 89 (23) |
| EPO | NA | cytokine | NA | -4.00e-01 | 0.0e+00 | CDKN1A,CXCL12,CXCR4,FOS,ID2,NFKBIA,PLCB2,Podxl,TLR4,TNFRSF11B | 85 (18) |
| bucladesine | NA | chemical toxicant | NA | -4.00e-01 | 0.0e+00 | ACER2,CCND1,CCR5,CDKN1A,CRYAB,CXCR4,FOS,IRAK2,KITLG,Mt1,NR0B1,PTCH1,SFTPB,SLC2A1,Slco1a4,TGFB3 | 105 (24) |
| phenobarbital | NA | chemical drug | NA | -4.10e-01 | 0.0e+00 | CCND1,CDKN1A,INSIG1,Slco1a4,SLCO1C1 | 59 (12) |
| TNF | -1.50e-01 | cytokine | NA | -4.10e-01 | 0.0e+00 | ADAMTS4,ADORA1,CA12,Casp12,CCND1,CCR5,CDH11,CDKN1A,CNR2,CRYAB,CXCL12,CXCR4,CYBB,CYYR1,DBI,DOCK8,ELOVL7,ENPP3,FOS,GADD45G,GPD1,IL1R2,INSIG1,IRAK2,KITLG,LAMP3,LCN2,LFNG,LGALS3,MERTK,MFSD2A,Mt1,NCF1,NFKBIA,NOTCH4,NRARP,PEX11A,PGF,PIK3C2B,PILRB,PLA2G3,PLIN4,POSTN,POU3F2,RGS1,SERPINB10,SFTPB,SGK1,SLC19A3,SLC2A1,SLC40A1,Slco1a4,SPSB1,TERF2IP,TGFB3,TLR2,TLR4,TNFRSF11A,TNFRSF11B,USP2,WNT7A | 120 (23) |
| XDH | 2.40e-01 | enzyme | NA | -4.20e-01 | 0.0e+00 | CCR5,CXCR4,CYBB,SLC2A1 | 97 (22) |
| calcimycin | NA | chemical reagent | NA | -4.20e-01 | 0.0e+00 | FOS,LCN2,SLC2A1,TLR2,TLR4 | 71 (18) |
| GSK3B | -2.40e-01 | kinase | NA | -4.40e-01 | 0.0e+00 | CCND1,CDH11,CDKN1A,FOS,LCN2,MYH6,NFE2L3 | 102 (26) |
| AKT1 | 1.80e-01 | kinase | NA | -4.40e-01 | 0.0e+00 | AURKB,CCND1,CDKN1A,CXCR4,FOS,LCN2,MYH6,PEX11A,SLC2A1 | 83 (22) |
| TSC2 | 6.00e-02 | other | NA | -4.50e-01 | 0.0e+00 | CCND1,CDKN1A,CRYAB,CST6,CXCL12,FOS,Ifi47,LGALS3,Mt1,SLC2A1 | 86 (21) |
| CYBB | -6.00e-01 | enzyme | NA | -4.50e-01 | 0.0e+00 | CDKN1A,CXCL12,CYBB,TGFB3,TNFRSF11A | 115 (20) |
| SELPLG | 0.00e+00 | other | NA | -4.50e-01 | 0.0e+00 | CDKN1A,CLK1,CXCR4,FOS,IL1R2 | 76 (14) |
| RUNX1 | -3.80e-01 | transcription regulator | NA | -4.50e-01 | 0.0e+00 | CCND1,CDKN1A,GPATCH4,ID2,Irgm1,MAP3K6,Mt1,PLEK,Podxl,PTCH1,ZBTB16 | 64 (13) |
| HIVEP1 | -2.30e-01 | transcription regulator | NA | -4.50e-01 | 0.0e+00 | CARD11,IL1R2,IRAK2,NFKBIA,TLR4 | NA |
| NPC1 | 2.10e-01 | transporter | NA | -4.50e-01 | 0.0e+00 | CCND1,CCR5,GPR34,LGALS3,MERTK,PLIN4,TLR4 | 67 (13) |
| JAK1/2 | NA | group | NA | -4.50e-01 | 0.0e+00 | CA12,GBP5,Ifi47,RPRML,RSPO2 | NA |
| COP1 | NA | enzyme | NA | -4.50e-01 | 0.0e+00 | CA12,CDKN1A,FOS,PEX11A,SLC26A2 | 67 (12) |
| SIX1 | -3.10e-01 | transcription regulator | NA | -4.50e-01 | 1.0e-02 | CRYAB,ERBB3,LFNG,MYBPH,POSTN | 23 (4) |
| HFE | 4.00e-02 | transmembrane receptor | NA | -4.50e-01 | 1.0e-02 | GADD45G,LCN2,MCM10,MFSD2A,Mt1 | 32 (5) |
| PAX3-FOXO1 | NA | fusion gene/product | NA | -4.50e-01 | 5.0e-02 | CCND1,CDKN1A,CXCR4,DBI,ERBB3,RPL6 | NA |
| miR-29b-3p (and other miRNAs w/seed AGCACCA) | NA | mature microRNA | NA | -4.60e-01 | 0.0e+00 | CCND1,ID2,INSIG1,PTP4A3,TGFB3 | 72 (7) |
| Sb202190 | NA | chemical drug | NA | -4.70e-01 | 1.0e-02 | CCND1,CDKN1A,FOS,P4HA1,SGK1 | 80 (22) |
| TLR2 | -7.60e-01 | transmembrane receptor | NA | -4.80e-01 | 0.0e+00 | CCR5,CDKN1A,CYBB,FOS,POSTN,SLC40A1,TLR2,TLR4 | 86 (17) |
| cyclophosphamide | NA | chemical drug | NA | -4.80e-01 | 0.0e+00 | Ctla2a,FOS,IL1R2,KITLG,LGALS3,RBM3,SLC34A2 | NA |
| STAT3 | 1.80e-01 | transcription regulator | NA | -4.80e-01 | 0.0e+00 | AHR,CCND1,CCR5,CDH11,CDKN1A,CXCR4,FOS,GADD45G,GBP5,ID2,Irgm1,LCN2,Mt1,NR0B1,ROR1,RPE65,SFTPB,SGK1,SLC2A1 | 99 (20) |
| P38 MAPK | NA | group | NA | -5.00e-01 | 0.0e+00 | CCND1,CDKN1A,CXCL12,CXCR4,CYBB,FOS,MYBPH,POSTN,SGK1,TLR2 | 83 (22) |
| IL3 | NA | cytokine | NA | -5.00e-01 | 0.0e+00 | CCND1,CDKN1A,CXCR4,FOS,GADD45G,LAMP3,LCN2,Mt1,NCF1,PLCB2,RBM3,RPL6,SLC2A1,TLR2,TLR4,TNFRSF11A | 95 (20) |
| IL1B | -3.00e-02 | cytokine | NA | -5.10e-01 | 0.0e+00 | ADAMTS4,CA12,CCND1,CCR5,CDKN1A,CNR2,CRYAB,CXCL12,CXCR4,CYBB,DBI,FKBP5,FOS,GBP5,HELZ2,ID2,Ifi47,IL1R2,IRAK2,LCN2,Mt1,NFKBIA,PLA2G3,POSTN,SLC19A3,SLC2A1,Slco1a4,TGFB3,TLR2,TLR4,TNFRSF11A,TNFRSF11B | 94 (16) |
| CSF3 | NA | cytokine | NA | -5.20e-01 | 0.0e+00 | CSF3R,CXCL12,CXCR4,CYBB,FOS,GADD45G,KITLG,LCN2,PLCB2,RGS1,TLR2,TLR4 | 102 (17) |
| LDL | NA | complex | NA | -5.20e-01 | 0.0e+00 | CCND1,CDKN1A,CYBB,FOS,GJA5,INSIG1,NCF1,SLC2A1,TLR2,TLR4 | 74 (18) |
| cisplatin | NA | chemical drug | NA | -5.20e-01 | 0.0e+00 | Casp12,CCND1,CCR5,CDKN1A,Ctla2a,CYBB,ERBB3,FOS,ID2,LCN2,LGALS3,Mt1,NCF1,NFKBIA,RBM3,SLC2A1,SLC34A2,TLR4,UHRF1,USP2 | 104 (23) |
| estrogen | NA | chemical drug | NA | -5.30e-01 | 0.0e+00 | CCND1,CDKN1A,CXCL12,CYBB,ERBB3,FOS,LCN2,PLIN4,SFTPB,TGFB3,TNFRSF11B,UHRF1 | 81 (22) |
| STAT5A | -5.00e-02 | transcription regulator | NA | -5.50e-01 | 0.0e+00 | CCND1,CCR5,CDKN1A,FOS,GADD45G,ID2,LCN2,SLC2A1,SLC34A2,TNFRSF11A | 95 (19) |
| EP300 | -1.00e-01 | transcription regulator | NA | -5.50e-01 | 0.0e+00 | CA12,CCND1,CDKN1A,CXCR4,FOS,ID2,KCNIP3,NFKBIA,PLEKHF1,SLC2A1,SPSB1,TESC,TLR2,WNT7A | 92 (18) |
| lenalidomide | NA | chemical drug | NA | -5.60e-01 | 0.0e+00 | CCND1,FZD10,RASGRP3,RGS1,RNF213,ROR1,SPSB1,TLR4 | 13 (2) |
| kainic acid | NA | chemical toxicant | NA | -5.60e-01 | 3.0e-02 | CCND1,CIART,FOS,LCN2,PER1 | NA |
| EZH2 | 0.00e+00 | transcription regulator | NA | -5.60e-01 | 0.0e+00 | CA6,CCND1,CCR5,CDKN1A,CSF3R,CXCR4,FKBP5,KITLG,LCN2,NFKBIA,PER1,PGF,POU2F3,RPL10A,TGFB3,ZBTB16 | 97 (23) |
| MAPK3 | 4.00e-02 | kinase | NA | -5.70e-01 | 2.0e-02 | CCND1,CDKN1A,FOS,RPE65 | NA |
| YY1 | -6.00e-02 | transcription regulator | NA | -5.80e-01 | 0.0e+00 | AURKB,CCR5,CD93,CDKN1A,CRYAB,CXCL12,CXCR4,CYBB,FOS,GADD45G,ID2,IL1R2,MYH6,UHRF1 | 98 (22) |
| SELP | 1.20e-01 | transmembrane receptor | NA | -5.80e-01 | 0.0e+00 | CDKN1A,CLK1,CXCR4,IL1R2 | 37 (8) |
| CREBBP | -2.50e-01 | transcription regulator | NA | -5.80e-01 | 0.0e+00 | CCND1,CCR5,CDKN1A,CXCL12,CXCR4,CYBB,EHHADH,FOS,KCNIP3,NFKBIA,PLEKHF1,SFTPB,SPSB1,TESC,TLR2,WNT7A | 72 (16) |
| TGFB3 | -6.50e-01 | growth factor | NA | -5.90e-01 | 2.0e-02 | CDKN1A,FOS,TGFB3,TNFRSF11B | NA |
| PPP3R1 | 9.00e-02 | phosphatase | NA | -6.00e-01 | 0.0e+00 | CYYR1,SFTPB,SLC34A2,TNFRSF11A,USP2 | NA |
| PTEN | -1.50e-01 | phosphatase | NA | -6.00e-01 | 0.0e+00 | AURKB,CA12,CCND1,CDKN1A,CST6,CXCR4,EHHADH,ERBB3,FOS,GJA5,GPR157,GPR179,LAMP3,LGALS3,NOTCH4,NR0B1,SFTPB,STARD8,TNFRSF11B,ZBTB16 | 104 (23) |
| Vegf | NA | group | NA | -6.10e-01 | 0.0e+00 | AHR,AURKB,CD93,CRYAB,CXCL12,CXCR4,CYYR1,EHHADH,ERBB3,FKBP5,FOS,INSIG1,KITLG,LCN2,NOTCH4,NRARP,PGF,SGK1,TGFB3,TNFRSF11A,TNFRSF11B | 90 (19) |
| calcitriol | NA | chemical drug | NA | -6.10e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,CXCL12,CYBB,ERBB3,FIGNL1,FOS,GADD45G,ID2,LCN2,MFSD2A,NFKBIA,PIK3AP1,RUNX1T1,SLC34A2,TLR2,TLR4,TNFRSF11B | 79 (16) |
| TCF12 | -2.80e-01 | transcription regulator | NA | -6.20e-01 | 4.0e-02 | CD93,CDKN1A,ID2,ZBTB16 | NA |
| SMAD3 | -1.70e-01 | transcription regulator | NA | -6.20e-01 | 0.0e+00 | ADORA1,CCND1,CDH11,CDKN1A,FOS,ID2,PTP4A3,SFTPB,TGFB3 | 112 (22) |
| S100A8 | 1.00e-02 | other | NA | -6.40e-01 | 0.0e+00 | ADAMTS4,C1QB,CCND1,NFKBIA,PER1,POSTN,SGK1 | 104 (23) |
| NCOA2 | -1.40e-01 | transcription regulator | NA | -6.50e-01 | 0.0e+00 | ADORA1,AHR,CCND1,CDKN1A,GBP5,GPR34,NFKBIA,SFTPB | 73 (18) |
| FBXW7 | 0.00e+00 | enzyme | NA | -6.50e-01 | 0.0e+00 | CARD11,NFE2L3,NFKBIA,NOTCH4,TLR4 | 38 (7) |
| NOX4 | -3.40e-01 | enzyme | NA | -6.50e-01 | 0.0e+00 | CDKN1A,CYBB,NCF1,SLC2A1 | 98 (22) |
| TET2 | -1.20e-01 | enzyme | NA | -6.50e-01 | 1.0e-02 | ASPA,MYH6,RGS1,SLC2A1,ZBTB16 | NA |
| ERBB3 | -6.90e-01 | kinase | NA | -6.60e-01 | 0.0e+00 | CCND1,CDKN1A,CXCL12,CXCR4,ERBB3,SGK1 | 82 (23) |
| PAX7 | 1.20e-01 | transcription regulator | NA | -6.60e-01 | 0.0e+00 | AHR,CDH11,CXCR4,ID2 | NA |
| INSR | -1.40e-01 | kinase | NA | -6.60e-01 | 2.0e-02 | CA6,CCND1,CDKN1A,CXCR4,FOS,INSIG1,PNPLA2,SLC2A1,TGFB3,TLR2,UHRF1 | NA |
| PKD1 | -1.60e-01 | ion channel | NA | -6.60e-01 | 5.0e-02 | CDKN1A,SLC16A4,SLC5A10,SYNJ2,TNFRSF11B | NA |
| TICAM1 | NA | other | NA | -6.60e-01 | 5.0e-02 | Ifi47,Irgm1,NFKBIA,TLR2 | NA |
| EGFR | -2.00e-01 | kinase | NA | -6.70e-01 | 0.0e+00 | CCND1,CDKN1A,CLK1,CRYAB,CXCL12,CXCR4,ERBB3,FOS,LCN2,NFKBIA,POSTN,SLC26A2,SLC2A1,TNFRSF11B | 95 (18) |
| MEF2C | -7.00e-02 | transcription regulator | NA | -6.70e-01 | 0.0e+00 | ASPA,CCR5,CDKN1A,CXCR4,FOS,GJA5,MYH6,POSTN | 72 (13) |
| cholecalciferol | NA | chemical - endogenous mammalian | NA | -6.80e-01 | 1.0e-02 | FOS,MYH6,NFYA,RGS1,TNFRSF11B | 41 (7) |
| medroxyprogesterone acetate | NA | chemical drug | NA | -6.80e-01 | 0.0e+00 | ADCY4,CCND1,CCR5,CDKN1A,CSF3R,CXCR4,ERBB3,ID2,NFKBIA,NOTCH4,P4HA1,PTCH1,SGK1,SLC2A1,TGFB3,ZBTB16 | 98 (20) |
| RB1 | -3.00e-01 | transcription regulator | NA | -6.90e-01 | 0.0e+00 | AURKB,CCND1,CDKN1A,FOS,GPR157,GPR179,ID2,MCM10,MYH6,NFKBIA,PER1,TRIM72 | 75 (22) |
| EGR1 | -5.70e-01 | transcription regulator | NA | -6.90e-01 | 3.0e-02 | CCND1,CDKN1A,PNPLA2,SGK1,TLR4 | NA |
| GATA1 | NA | transcription regulator | NA | -6.90e-01 | 1.0e-02 | CCND1,CCR5,CDKN1A,CYBB,NRARP,PLEK,Podxl,UHRF1 | 43 (7) |
| NPY | 2.50e-01 | other | NA | -7.00e-01 | 0.0e+00 | FKBP5,FOS,PER1,PNPLA2 | 76 (18) |
| GW3965 | NA | chemical reagent | NA | -7.00e-01 | 0.0e+00 | DHRS9,GADD45G,MERTK,MLXIPL,NFKBIA,RGS1,UHRF1 | 13 (2) |
| nicotine | NA | chemical drug | NA | -7.00e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,DBI,FOS,HCRTR2,LGALS3,POSTN,WNT7A | 89 (26) |
| EGF | 2.20e-01 | growth factor | NA | -7.10e-01 | 0.0e+00 | AURKB,CCND1,CDH11,CDKN1A,CXCR4,ERBB3,FOS,ID2,IL1R2,LCN2,NCF1,PER1,PGF,Podxl,TGFB3,TNFRSF11B,WNT7A | 94 (25) |
| SORL1 | NA | transporter | NA | -7.10e-01 | 0.0e+00 | COL13A1,CXCL12,FOS,PGF,ROR1,TLR4,TNFRSF11B,WNT7A | 56 (7) |
| LMO2 | -2.70e-01 | transcription regulator | NA | -7.10e-01 | 1.0e-02 | AHR,CD93,CDKN1A,GBP5,GPR34,PSTPIP1,SLC40A1,TLR2 | NA |
| LDB1 | 1.70e-01 | transcription regulator | NA | -7.10e-01 | 1.0e-02 | AHR,CD93,CDKN1A,GBP5,GPR34,PSTPIP1,SLC40A1,TLR2 | NA |
| NOS2 | NA | enzyme | NA | -7.30e-01 | 0.0e+00 | CDKN1A,CSF3R,GPD1,LCN2,MYH6,NFKBIA,SLC40A1,TLR4 | 94 (21) |
| NRG1 | -2.00e-01 | growth factor | NA | -7.30e-01 | 0.0e+00 | CCND1,CDKN1A,CXCR4,ERBB3,FOS,MYH6,SGK1,SLC2A1 | 79 (20) |
| PI3K (complex) | NA | complex | NA | -7.40e-01 | 0.0e+00 | CCND1,CDKN1A,CNR2,CXCR4,CYBB,FOS,LCN2,NFKBIA,POSTN,SGK1,TLR4,TNFRSF11A | 73 (18) |
| GLI1 | -3.80e-01 | transcription regulator | NA | -7.40e-01 | 0.0e+00 | CA12,CCND1,CDH11,CDKN1A,CST6,FOS,ID2,IL1R2,INSIG1,KITLG,LFNG,PTCH1 | 80 (17) |
| HDAC1 | 1.70e-01 | transcription regulator | NA | -7.60e-01 | 0.0e+00 | CCND1,CDKN1A,FOS,LCN2,MCM10,Mt1,NFKBIA,SGK1,Tcam1,UHRF1 | 94 (23) |
| BAG1 | 2.30e-01 | other | NA | -7.60e-01 | 0.0e+00 | CCND1,CDKN1A,FKBP5,FOS | 94 (25) |
| mir-146 | NA | microRNA | NA | -7.60e-01 | 2.0e-02 | FOS,IRAK2,NFYA,TLR4 | NA |
| morphine | NA | chemical drug | NA | -7.70e-01 | 0.0e+00 | CCND1,CCR5,CDKN1A,CNR2,CYBB,ERBB3,FOS,FZD10,TLR2,TLR4,WNT7A | 89 (25) |
| E. coli serotype 0127B8 lipopolysaccharide | NA | chemical - endogenous non-mammalian | NA | -7.80e-01 | 0.0e+00 | ADORA1,CXCL12,CXCR4,GJA5,Ifi47,LCN2,LGALS3,NFKBIA,TLR2,TLR4,TNFRSF11B | 87 (16) |
| NFkB (complex) | NA | complex | NA | -7.80e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,CXCL12,CXCR4,CYBB,FOS,GPR34,HIF3A,LCN2,NFKBIA,SLC2A1,SLC2A12,TERF2IP,TGFB3,TLR2,TLR4,TNFRSF11B | 84 (19) |
| HIF1A | -1.50e-01 | transcription regulator | NA | -7.90e-01 | 0.0e+00 | AHR,CCND1,CCR5,CDKN1A,CXCL12,CXCR4,FOS,HIF3A,ID2,KITLG,NFKBIA,NRARP,P4HA1,PGF,SLC16A4,SLC2A1,SLC40A1,TGFB3,TLR2,TNFRSF11B | 90 (18) |
| Growth hormone | NA | group | NA | -7.90e-01 | 0.0e+00 | CCND1,FKBP5,FOS,NFKBIA,PIK3C2B,SGK1,SLC2A1,TGFB3 | 100 (23) |
| Tcf7 | -1.80e-01 | transcription regulator | NA | -7.90e-01 | 1.0e-02 | CD101,CDKN1A,CNR2,ID2,NCF1,PILRB,RASGRP3,TGFB3 | NA |
| homocysteine | NA | chemical - endogenous mammalian | NA | -7.90e-01 | 2.0e-02 | CCND1,CDKN1A,CXCL12,PGF | NA |
| FOXA1 | -2.00e-02 | transcription regulator | NA | -8.00e-01 | 2.0e-02 | CDKN1A,ERBB3,MLXIPL,SLC10A6,SPSB1 | NA |
| TEAD4 | -6.00e-02 | transcription regulator | NA | -8.10e-01 | 0.0e+00 | CCND1,CDKN1A,FKBP5,NFKBIA,POSTN,SH3D19 | 48 (9) |
| TNFSF10 | -5.20e-01 | cytokine | NA | -8.10e-01 | 1.0e-02 | CXCR4,FOS,NFKBIA,PER1,SLC2A1 | 80 (21) |
| PI3K (family) | NA | group | NA | -8.20e-01 | 2.0e-02 | CXCL12,CXCR4,FOS,SLC2A1 | NA |
| TGFBR2 | -2.80e-01 | kinase | NA | -8.20e-01 | 0.0e+00 | CCND1,CDKN1A,CRYAB,FKBP5,GADD45G,H2BC5,IL1R2,MFSD2A,NFKBIA,PIK3C2B,PTCH1,SLC2A1,TGFB3,TNFRSF11B | 83 (19) |
| CNTF | -1.30e-01 | cytokine | NA | -8.20e-01 | 0.0e+00 | CCR5,CXCR4,CYBB,FOS,LCN2,LGALS3,NUDT6,TLR2 | 72 (18) |
| ANGPT2 | -3.70e-01 | growth factor | NA | -8.30e-01 | 0.0e+00 | CDKN1A,CRYAB,CXCR4,CYBB,MYH6,NCF1,POSTN,TLR4 | 100 (21) |
| epinephrine | NA | chemical - endogenous mammalian | NA | -8.30e-01 | 0.0e+00 | CCND1,CDKN1A,CXCR4,PER1,Slco1a4 | 91 (25) |
| ZBTB16 | 1.21e+00 | transcription regulator | NA | -8.30e-01 | 0.0e+00 | ACER2,CCND1,CD180,CDKN1A,GALNT6,ID2,LY86,SLC2A1,ZBTB16 | 68 (13) |
| AGT | 2.70e-01 | growth factor | NA | -8.40e-01 | 0.0e+00 | ADAMTS4,CCND1,CCR5,CDKN1A,CXCL12,CYBB,ENDOU,FKBP5,FOS,KITLG,LCN2,LGALS3,MYH6,NCF1,NFKBIA,NOTCH4,PGF,POSTN,SGK1,SLC10A6,SLC2A1,SLC34A2,TGFB3,TNFRSF11B,UHRF1 | 114 (18) |
| VDR | 5.70e-01 | transcription regulator | NA | -8.40e-01 | 1.0e-02 | CCND1,CDKN1A,GADD45G,GPD1,PNPLA2,SLC34A2,TLR2 | NA |
| E. coli B5 lipopolysaccharide | NA | chemical - endogenous non-mammalian | NA | -8.60e-01 | 0.0e+00 | CCND1,CCR5,CDKN1A,CSF3R,CXCR4,CYBB,DBI,FOS,IL1R2,MLXIPL,NCF1,NFKBIA,TGFB3,TLR2,TLR4 | 78 (16) |
| IL1 | NA | group | NA | -8.60e-01 | 0.0e+00 | ADAMTS4,AHR,CDKN1A,FOS,IL1R2,KITLG,SFTPB,SLC2A1,TGFB3,TLR2,TLR4,TNFRSF11B | 108 (19) |
| peptidoglycan | NA | chemical - endogenous non-mammalian | NA | -8.70e-01 | 0.0e+00 | CCR5,CXCR4,FOS,TLR2,TLR4 | 85 (19) |
| 8-bromo-cAMP | NA | chemical reagent | NA | -8.80e-01 | 0.0e+00 | ADCY4,CCND1,CDKN1A,CSF3R,ERBB3,FOS,ID2,KITLG,MYH6,NFKBIA,NFYA,NOTCH4,P4HA1,PTCH1,SGK1,SLC2A1,Slco1a4,TGFB3,ZBTB16 | 114 (23) |
| NGF | 1.60e-01 | growth factor | NA | -8.80e-01 | 1.0e-02 | ACER2,CCND1,CDKN1A,CRYAB,FOS,GADD45G,SLC40A1 | NA |
| EIF2AK2 | -1.00e-02 | kinase | NA | -8.90e-01 | 0.0e+00 | CCND1,CDKN1A,FOS,H2BC5,NFKBIA | 83 (21) |
| ID2 | 1.04e+00 | transcription regulator | NA | -8.90e-01 | 0.0e+00 | AURKB,CCND1,CCR5,CDKN1A,CXCR4,GADD45G,PIK3C2B,ZBTB16 | 64 (15) |
| 10E,12Z-octadecadienoic acid | NA | chemical - endogenous mammalian | NA | -9.00e-01 | 0.0e+00 | CLEC12A,ENDOU,FMO2,MCM10,NOTCH4,PNPLA2,RGS1 | NA |
| tamoxifen | NA | chemical drug | NA | -9.00e-01 | 0.0e+00 | ADORA1,CCND1,CDH11,CDKN1A,CXCL12,CXCR4,ERBB3,FOS,LAMP3,LGALS3,SFTPB,SLC2A1,SLC34A2,TLR4 | 86 (22) |
| ITK | -1.50e-01 | kinase | NA | -9.10e-01 | 1.0e-02 | AHR,FOS,SLC2A1,ZBTB16 | 74 (17) |
| beta-estradiol | NA | chemical - endogenous mammalian | NA | -9.10e-01 | 0.0e+00 | ACER2,ADAMTS4,ADCY4,ADORA1,AHR,CA12,CCND1,CCR5,CD93,CDH11,CDKN1A,COL13A1,CSF3R,CXCL12,CXCR4,CYBB,CYTH4,DHRS9,ERBB3,FMO2,FOS,GADD45G,GRHL2,HCRTR2,ID2,IL1R2,INSIG1,IP6K3,KITLG,LCN2,LGALS3,MCM10,MERTK,MYH6,NFE2L3,NFKBIA,NFYA,NOTCH4,NR0B1,P4HA1,PEX11A,PIK3C2B,PTCH1,RGS1,RPL6,SGK1,SLC26A2,SLC2A1,SLC34A2,Slco1a4,STON1,TGFB3,TJAP1,TLR2,TLR4,TNFRSF11B,WNT7A,ZBTB16 | 115 (20) |
| LGALS1 | 1.10e-01 | other | NA | -9.10e-01 | 0.0e+00 | ADAMTS4,AHR,CDKN1A,INSIG1,LGALS3,PTCH1 | 73 (14) |
| CXCR4 | -6.30e-01 | G-protein coupled receptor | NA | -9.30e-01 | 0.0e+00 | CCND1,CDH11,CDKN1A,CXCL12,CXCR4,ID2,Podxl,ZBTB16 | 76 (22) |
| Mek | NA | group | NA | -9.30e-01 | 0.0e+00 | CCND1,CDKN1A,CRYAB,ERBB3,FOS,ID2,Ifi47,POU3F2,SLC26A2,SLC2A1,STON1 | 73 (18) |
| GCG | NA | other | NA | -9.40e-01 | 3.0e-02 | FOS,NFYA,PHLDB2,SLC2A1 | NA |
| Tgf beta | NA | group | NA | -9.40e-01 | 0.0e+00 | AHR,CCND1,CDH11,CDKN1A,CXCR4,CYBB,FOS,HIF3A,ID2,MERTK,MLXIPL,POSTN,SGK1,TLR2,TMEM252,TNFRSF11A,TNFRSF11B | 109 (22) |
| CCL2 | -1.00e-01 | cytokine | NA | -9.50e-01 | 0.0e+00 | CCND1,FOS,LCN2,NCF1,SLC19A3,SLC40A1 | 101 (22) |
| HRAS | 3.90e-01 | enzyme | NA | -9.50e-01 | 1.0e-02 | AFAP1L1,AURKB,CCND1,CDKN1A,CXCL12,FOS,GADD45G,ID2,NFKBIA,PGF,POSTN,PRR5,TGFB3,TNFRSF11B | 82 (21) |
| lithium chloride | NA | chemical drug | NA | -9.60e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,FOS,PER1,POSTN | 91 (24) |
| bleomycin | NA | biologic drug | NA | -9.60e-01 | 0.0e+00 | CCR5,CDH11,CDKN1A,CIART,CXCL12,CXCR4,GPR34,KITLG,LGALS3,MAP3K6,TLR2,UHRF1 | 100 (19) |
| CD 437 | NA | chemical drug | NA | -9.70e-01 | 4.0e-02 | CDKN1A,FKBP5,FOS,INO80B,NFKBIA | NA |
| CTNNB1 | 4.00e-02 | transcription regulator | NA | -9.70e-01 | 0.0e+00 | AHR,CCND1,CDH11,CDKN1A,CXCL12,ERBB3,FOS,GADD45G,GRHL2,ID2,KITLG,LFNG,LGALS3,MYH6,NR0B1,Podxl,POU3F2,PTCH1,RPL10A,RPL6,SGK1,SLC26A2,TGFB3,TNFRSF11B,WNT7A | 106 (20) |
| Ca2+ | NA | chemical - endogenous mammalian | NA | -9.90e-01 | 0.0e+00 | AHR,CCND1,CDKN1A,CXCR4,FOS,NFKBIA,PER1,RNF152,SGK1,TLR4,TNFRSF11B | 66 (15) |
| DGCR8 | -1.70e-01 | enzyme | NA | -1.00e+00 | 0.0e+00 | CCND1,ERBB3,FOS,ID2,POU3F2 | 62 (12) |
| cytarabine | NA | chemical drug | NA | -1.00e+00 | 0.0e+00 | CD180,CDKN1A,TGFB3,TLR2 | 68 (14) |
| glutamine | NA | chemical - endogenous mammalian | NA | -1.00e+00 | 0.0e+00 | CCND1,CDKN1A,FOS,MYH6,NFKBIA | 76 (20) |
| miR-199a-5p (and other miRNAs w/seed CCAGUGU) | NA | mature microRNA | NA | -1.00e+00 | 1.0e-02 | CDKN1A,LCN2,WNT7A,ZBTB16 | NA |
| MEF2A | -2.40e-01 | transcription regulator | NA | -1.00e+00 | 1.0e-02 | FOS,Ifi47,MYH6,TGFB3 | 43 (7) |
| MRTFA | NA | transcription regulator | NA | -1.00e+00 | 1.0e-02 | CXCL12,CXCR4,FOS,LCN2,SERPINB10,SGK1 | NA |
| ascorbic acid | NA | chemical - endogenous mammalian | NA | -1.00e+00 | 2.0e-02 | CDKN1A,PTCH1,SLC2A1,TNFRSF11B | NA |
| THZ1 | NA | chemical drug | NA | -1.00e+00 | 3.0e-02 | AEN,CST6,LGALS3,POSTN | NA |
| methapyrilene | NA | chemical drug | NA | -1.00e+00 | 4.0e-02 | CCND1,DBI,EHHADH,Mt1 | NA |
| TNFSF13B | 2.00e-01 | cytokine | NA | -1.00e+00 | 5.0e-02 | AURKB,FIGNL1,PGF,PLEK | NA |
| ESR2 | -1.00e-01 | ligand-dependent nuclear receptor | NA | -1.02e+00 | 0.0e+00 | ADORA1,CA12,CCND1,CCR5,CD93,CDKN1A,COL13A1,CXCL12,CYTH4,DBI,ENPP3,FKBP5,FOS,INSIG1,IP6K3,KITLG,MYH6,NFE2L3,NFKBIA,NFYA,POSTN,SGK1,SLC26A2,STON1,TNFRSF11B | 101 (24) |
| KLF2 | -5.00e-02 | transcription regulator | NA | -1.02e+00 | 0.0e+00 | CCR5,CD93,CDKN1A,CXCR4,KITLG,NFKBIA,PGF,SLC2A1 | 62 (14) |
| BCL2 | -4.40e-01 | transporter | NA | -1.04e+00 | 2.0e-02 | CCND1,CDKN1A,FOS,NFKBIA | NA |
| EPAS1 | 1.40e-01 | transcription regulator | NA | -1.04e+00 | 0.0e+00 | CA12,CCND1,CCR5,CDKN1A,CXCL12,CXCR4,FOS,NRARP,PGF,SFTPB,SLC16A4,SLC2A1,SLC40A1,TGFB3,TNFRSF11B | 89 (23) |
| miR-146a-5p (and other miRNAs w/seed GAGAACU) | NA | mature microRNA | NA | -1.04e+00 | 0.0e+00 | COL13A1,CXCR4,IRAK2,MCM10,NFKBIA,TLR4,UHRF1 | NA |
| bisphenol A | NA | chemical - endogenous mammalian | NA | -1.05e+00 | 0.0e+00 | CCND1,CDKN1A,CXCL12,FOS,LCN2,PER1,POSTN,SGK1,TGFB3 | 102 (23) |
| Gm21596/Hmgb1 | NA | transcription regulator | NA | -1.06e+00 | 0.0e+00 | CDKN1A,CXCL12,CXCR4,TLR4 | 91 (18) |
| IL2 | NA | cytokine | NA | -1.07e+00 | 0.0e+00 | AHR,CCND1,CCR5,CDKN1A,CXCL12,CXCR4,CYTH4,FOS,GADD45G,GPR34,IL1R2,INSIG1,MFSD2A,PTCH1,SHISA3,SLC40A1,TLR2,TNFRSF11A,TNFRSF11B | 94 (19) |
| ID3 | 4.00e-02 | transcription regulator | NA | -1.07e+00 | 1.0e-02 | CCR5,CDKN1A,CXCR4,GADD45G,PIK3C2B,ZBTB16 | NA |
| tetradecanoylphorbol acetate | NA | chemical drug | NA | -1.07e+00 | 0.0e+00 | ADAMTS4,AHR,AURKB,CCND1,CDKN1A,CSF3R,CXCL12,CXCR4,CYBB,CYTH4,FKBP5,FOS,GPR34,GRHL2,ID2,INO80B,ISLR2,LCN2,MAST4,NCF1,NFKBIA,PER1,PLCB2,RGS1,SERPINB10,SFTPB,SGK1,SLC2A1,TLR2,TLR4,TNFRSF11B | 111 (18) |
| NFKB2 | -4.70e-01 | transcription regulator | NA | -1.07e+00 | 0.0e+00 | CCND1,CDKN1A,CXCL12,CXCR4,FOS,GBP5 | 65 (20) |
| IL13 | NA | cytokine | NA | -1.08e+00 | 0.0e+00 | ADAMTS4,ADORA1,CCR5,CD101,CXCR4,CYBB,IL1R2,KITLG,MERTK,POSTN,SLC19A3,TLR4,TNFRSF11A,TNFRSF11B | 118 (22) |
| PTGES | -7.00e-02 | enzyme | NA | -1.09e+00 | 0.0e+00 | CDKN1A,CYBB,ERBB3,MYH6,NCF1 | NA |
| AGTR1 | 6.00e-02 | G-protein coupled receptor | NA | -1.09e+00 | 0.0e+00 | CCND1,FOS,SGK1,TGFB3 | 103 (23) |
| rolipram | NA | chemical drug | NA | -1.09e+00 | 0.0e+00 | CXCR4,FOS,IL1R2,SFTPB | 95 (20) |
| SP1 | -1.50e-01 | transcription regulator | NA | -1.09e+00 | 0.0e+00 | ADCY4,AFAP1L1,CCND1,CDKN1A,CRYAB,CXCL12,CXCR4,FOS,Mt1,NFKBIA,SGK1,SLC2A1,SLC2A12,TLR2 | 84 (25) |
| SPI1 | -3.50e-01 | transcription regulator | NA | -1.09e+00 | 0.0e+00 | CCND1,CD180,CDKN1A,CSF3R,CYBB,FOS,HELZ2,ID2,IL1R2,LAMP3,NCF1,TLR2,TLR4 | 91 (19) |
| PTGS2 | -3.40e-01 | enzyme | NA | -1.10e+00 | 0.0e+00 | CCND1,CDKN1A,CLEC12A,CXCL12,CXCR4,CYBB,ERBB3,FOS | 79 (19) |
| RNF187 | 1.40e-01 | enzyme | NA | -1.10e+00 | 1.0e-02 | AEN,AHR,CCND1,CDKN1A | NA |
| SMARCA4 | -1.30e-01 | transcription regulator | NA | -1.11e+00 | 0.0e+00 | AHR,CCND1,CDH11,CDKN1A,CLK1,CXCR4,DHRS9,EVA1A,FKBP5,FMO2,FOS,GADD45G,LGALS3,Mt1,MYBPH,PTCH1,RGS1,SFTPB,SLC2A1,SLC40A1,TLR2,TRIM36,WNT7A | 85 (21) |
| HDAC2 | -4.00e-02 | transcription regulator | NA | -1.12e+00 | 0.0e+00 | CCND1,CDKN1A,CYBB,MCM10,NFKBIA,Tcam1 | 96 (23) |
| tretinoin | NA | chemical drug | NA | -1.13e+00 | 0.0e+00 | ADAMTS4,AHR,CCND1,CCR5,CD101,CD93,CDKN1A,CSF3R,CXCR4,CYBB,DBI,DHRS9,FOS,FZD10,ID2,KITLG,LCN2,MEI1,MERTK,Mt1,NCF1,NIPAL4,PLCB2,PLEK,Podxl,POSTN,PTCH1,PTP4A3,RNF213,ROR1,RPL6,SFTPB,TGFB3,TLR2,TNFRSF11A,TNFRSF11B,ZBTB16 | 109 (17) |
| AREG | 1.10e-01 | growth factor | NA | -1.13e+00 | 0.0e+00 | AURKB,CCND1,CDH11,CXCR4,FOS,H2BC5,NIPAL4 | 94 (23) |
| poly rI:rC-RNA | NA | biologic drug | NA | -1.14e+00 | 0.0e+00 | Casp12,CDKN1A,CXCR4,FOS,GBP5,HELZ2,IRAK2,Irgm1,MERTK,NFKBIA,NOTCH4,RGS1,RPL10A,SLC40A1,SPSB1,TLR2,TLR4,TNFRSF11B | 92 (17) |
| raloxifene | NA | chemical drug | NA | -1.15e+00 | 0.0e+00 | CCND1,CDKN1A,CLK1,CXCL12,ERBB3,TGFB3,TNFRSF11B | 79 (19) |
| THPO | NA | cytokine | NA | -1.15e+00 | 2.0e-02 | AURKB,CCND1,FOS,NFKBIA | NA |
| Pam3-Cys-Ser-Lys4 | NA | chemical reagent | NA | -1.17e+00 | 0.0e+00 | CCR5,CD180,NFKBIA,RGS1,SLC2A1,SLC40A1,TGFB3,TLR2,TLR4,TNFRSF11A | 95 (15) |
| thapsigargin | NA | chemical toxicant | NA | -1.18e+00 | 0.0e+00 | Casp12,CCND1,CDKN1A,FOS,INSIG1,LAMP3,NFKBIA,SGK1,TLR2 | 102 (23) |
| RET | 2.60e-01 | kinase | NA | -1.18e+00 | 0.0e+00 | CCND1,CRYAB,CXCL12,CXCR4,FOS,MYH6 | 81 (22) |
| F2 | 0.00e+00 | peptidase | NA | -1.19e+00 | 0.0e+00 | CCND1,CDKN1A,CXCR4,CYBB,DHRS9,FOS,NCF1,NFKBIA,SLC2A12,TGFB3 | 63 (16) |
| BCL11B | -1.00e-02 | transcription regulator | NA | -1.19e+00 | 0.0e+00 | ADORA1,AHR,CDKN1A,ID2,ZBTB16 | NA |
| SRF | -7.00e-02 | transcription regulator | NA | -1.19e+00 | 0.0e+00 | CDKN1A,CXCR4,CYBB,FOS,GADD45G,GPATCH4,HIF3A,LCN2,MYH6,SERPINB10,SLC2A1 | 50 (8) |
| CAMP | 5.00e-02 | other | NA | -1.20e+00 | 0.0e+00 | AHR,CSF3R,CXCR4,IL1R2,NOTCH4,TLR2,TLR4 | 114 (21) |
| LIF | -1.20e-01 | cytokine | NA | -1.20e+00 | 2.0e-02 | CCND1,CDKN1A,FOS,ID2,RPE65,TNFRSF11B | NA |
| NCOA3 | -1.60e-01 | transcription regulator | NA | -1.20e+00 | 0.0e+00 | AHR,CCND1,CDKN1A,LAMP3,NFKBIA,NR0B1,SFTPB,SLC2A1 | 87 (21) |
| LEF1 | -5.80e-01 | transcription regulator | NA | -1.20e+00 | 0.0e+00 | CARD11,CCND1,CD101,CDKN1A,CSF3R,CXCR4,ID2,LFNG,NCF1,NR0B1,PILRB,POU3F2,PTCH1,RASGRP3,SGK1,TLR2,TNFRSF11A | 78 (15) |
| TNC | -2.20e-01 | other | NA | -1.23e+00 | 0.0e+00 | ADAMTS4,CDH11,CDKN1A,CXCL12,FOS,ID2,TLR4 | 97 (21) |
| FOXM1 | -2.00e-01 | transcription regulator | NA | -1.24e+00 | 0.0e+00 | AURKB,CCND1,CDKN1A,CXCL12,FOS,PTCH1,SFTPB | 96 (20) |
| ATP | NA | chemical - endogenous mammalian | NA | -1.25e+00 | 0.0e+00 | AHR,CCND1,CCR5,CXCR4,FOS,LCN2,TLR4 | 83 (16) |
| dehydroisoandrosterone | NA | chemical - endogenous mammalian | NA | -1.25e+00 | 0.0e+00 | CCND1,FKBP5,LGALS3,MYH6,NFKBIA | 118 (22) |
| JAK2 | -2.40e-01 | kinase | NA | -1.26e+00 | 0.0e+00 | ACER2,CCND1,CDKN1A,CYBB,Fhod1,FOS,LCN2 | 87 (22) |
| KRAS | -2.50e-01 | enzyme | NA | -1.28e+00 | 0.0e+00 | AEN,AHR,AURKB,CCND1,CDH11,CDKN1A,CHST3,CRYAB,CSF3R,CXCL12,CXCR4,CYBB,FOS,LAMP3,LCN2,LGALS3,NCF1,NFKBIA,NR0B1,PHLDB2,PSTPIP1,PTCH1,RUNX1T1,SFTPB,SLC26A2,SLC2A1,SLC34A2,TESC,TLR2,TNFRSF11B | 75 (14) |
| IKBKE | -2.90e-01 | kinase | NA | -1.29e+00 | 0.0e+00 | CCND1,CXCL12,NFKBIA,PTCH1,SLC2A1 | 88 (21) |
| hydroxyurea | NA | chemical drug | NA | -1.29e+00 | 0.0e+00 | CCND1,CDKN1A,RASGRP3,TGFB3,UHRF1 | 85 (20) |
| PRKCA | -1.00e-01 | kinase | NA | -1.30e+00 | 0.0e+00 | CCND1,CDKN1A,CYBB,FOS,ID2,INSIG1,MLXIPL,NFKBIA,NOTCH4 | 83 (21) |
| Pdgf (complex) | NA | complex | NA | -1.31e+00 | 1.0e-02 | CCND1,CDKN1A,FOS,TGFB3 | NA |
| GATA3 | -7.00e-02 | transcription regulator | NA | -1.31e+00 | 0.0e+00 | CCND1,CCR5,CDKN1A,CST6,CXCR4,FOS,SLC2A1,ZBTB16 | 75 (19) |
| PARP1 | -2.40e-01 | enzyme | NA | -1.34e+00 | 0.0e+00 | CCND1,CCR5,CDKN1A,CXCL12,FOS,SFTPB,TLR4 | 84 (22) |
| MSB0011359C | NA | biologic drug | NA | -1.34e+00 | 0.0e+00 | CDKN1A,FOS,GBP5,Mt1,RGS1 | NA |
| RNF31 | 2.10e-01 | enzyme | NA | -1.34e+00 | 0.0e+00 | ADORA1,CCND1,CXCR4,IL1R2,TGFB3 | 74 (9) |
| RGS2 | 1.00e-01 | enzyme | NA | -1.34e+00 | 0.0e+00 | CXCL12,EVA1A,MFSD2A,PSTPIP1,SLC2A1 | NA |
| MRTFB | NA | transcription regulator | NA | -1.34e+00 | 0.0e+00 | CXCL12,CXCR4,LCN2,POSTN,SERPINB10,SGK1,SH3D19 | 54 (7) |
| CCR2 | NA | G-protein coupled receptor | NA | -1.34e+00 | 0.0e+00 | C1QB,CCR5,CXCL12,CXCR4,P4HA1 | 101 (21) |
| GRN | -2.00e-02 | growth factor | NA | -1.34e+00 | 0.0e+00 | C1QB,CCND1,GPR34,LGALS3,MERTK | NA |
| S100A9 | -2.00e-01 | other | NA | -1.34e+00 | 1.0e-02 | ADAMTS4,C1QB,CCND1,PER1,POSTN,SGK1 | 102 (22) |
| MAFB | 4.40e-01 | transcription regulator | NA | -1.34e+00 | 1.0e-02 | CXCL12,LGALS3,SLC40A1,SLC5A10,ZNF189 | NA |
| THZ531 | NA | chemical drug | NA | -1.34e+00 | 1.0e-02 | ARHGEF38,EHHADH,FKBP5,PTP4A3,SLC2A12 | NA |
| LEPR | -3.30e-01 | transmembrane receptor | NA | -1.34e+00 | 1.0e-02 | CNR2,FOS,GADD45G,ID2,IL1R2,LCN2 | NA |
| RUNX2 | 8.00e-02 | transcription regulator | NA | -1.35e+00 | 1.0e-02 | CCND1,CCR5,CDKN1A,LGALS3,TNFRSF11B | 99 (23) |
| TAFAZZIN | NA | enzyme | NA | -1.38e+00 | 0.0e+00 | AEN,CCND1,CD180,CXCL12,CXCR4,IRAK2,Irgm1,P4HA1,RNF213,SLC2A1,SLC40A1 | 51 (9) |
| hyaluronic acid | NA | chemical - endogenous mammalian | NA | -1.39e+00 | 0.0e+00 | CXCR4,FOS,NCF1,NFKBIA,TLR2,TLR4 | 82 (16) |
| STAT1 | -1.60e-01 | transcription regulator | NA | -1.40e+00 | 0.0e+00 | CCND1,CDKN1A,CSF3R,FOS,GBP5,Ifi47,IL1R2,Irgm1,LCN2,RNF213,TLR4 | 101 (21) |
| IL12 (complex) | NA | complex | NA | -1.41e+00 | 1.0e-02 | AHR,CCR5,FOS,GADD45G,TLR2,TLR4 | NA |
| ZBED6 | NA | transcription regulator | NA | -1.41e+00 | 0.0e+00 | COL13A1,KITLG,LAMP3,SGK1 | NA |
| NR5A2 | -3.20e-01 | ligand-dependent nuclear receptor | NA | -1.42e+00 | 0.0e+00 | C1QB,CCND1,CDKN1A,FOS,GADD45G,Mt1,NR0B1,TGFB3 | 74 (20) |
| MAPK8 | -3.30e-01 | kinase | NA | -1.44e+00 | 1.0e-02 | CCND1,CDKN1A,CYBB,FOS,PTCH1,TLR2 | 72 (15) |
| F2R | 1.10e-01 | G-protein coupled receptor | NA | -1.45e+00 | 0.0e+00 | CCND1,CDH11,COL13A1,CXCL12,FOS | 101 (21) |
| JUN | -3.60e-01 | transcription regulator | NA | -1.45e+00 | 1.0e-02 | C1QB,CCND1,CDH11,CDKN1A,FOS,ID2,LGALS3,MYH6,NFKBIA,SGK1,SLC2A1 | 108 (23) |
| MMP9 | 1.10e-01 | peptidase | NA | -1.46e+00 | 0.0e+00 | CCND1,CDKN1A,CXCL12,CXCR4,FOS,WNT7A | 80 (23) |
| RAS | NA | group | NA | -1.46e+00 | 0.0e+00 | CCND1,CDKN1A,CSF3R,FOS,Ifi47,POU3F2 | 92 (24) |
| APP | 7.00e-02 | other | NA | -1.47e+00 | 0.0e+00 | ADAMTS4,CA12,Casp12,CCND1,CCR5,CDKN1A,COL13A1,CXCL12,CXCR4,CYBB,DBI,FOS,H2BC5,Ifi47,Irgm1,KCNA4,LGALS3,MCM10,MERTK,Mt1,NCF1,RBM3,RNF213,RUNX1T1,SHISA3,TLR2,TLR4,TNFRSF11B | 100 (20) |
| YAP1 | NA | transcription regulator | NA | -1.47e+00 | 0.0e+00 | AURKB,CCND1,CDKN1A,CXCL12,CXCR4,ENDOU,FOS,ID2,KITLG,NFKBIA,P4HA1,RPL10A,RPL6,SGK1,UHRF1 | 91 (21) |
| ERK | NA | group | NA | -1.49e+00 | 1.0e-02 | CCND1,CDKN1A,FOS,LCN2,POSTN,SFTPB,SLC2A1 | 90 (24) |
| SHH | -1.80e-01 | peptidase | NA | -1.50e+00 | 1.0e-02 | CCND1,CD93,LFNG,PGF,PTCH1,TGFB3 | NA |
| IFNG | NA | cytokine | NA | -1.51e+00 | 0.0e+00 | ADORA1,AHR,C1QB,Casp12,CCND1,CCR5,CDKN1A,CHST3,CXCL12,CXCR4,CYBB,FKBP5,FOS,GBP5,GJA5,ID2,Ifi47,IRAK2,Irgm1,KITLG,LAMP3,LCN2,LGALS3,MERTK,MFSD2A,Mt1,NFE2L3,NFKBIA,PLEK,RGS1,SLC2A1,SLC40A1,TLR2,TLR4,TNFRSF11A,TNFRSF11B,ZBTB16 | 99 (21) |
| EDN1 | 1.00e-01 | cytokine | NA | -1.51e+00 | 1.0e-02 | CCND1,CXCR4,CYBB,FOS,NCF1,SLC2A1 | NA |
| IL18 | -1.70e-01 | cytokine | NA | -1.53e+00 | 4.0e-02 | CCR5,CXCL12,GADD45G,TLR4,TNFRSF11B | NA |
| spironolactone | NA | chemical drug | NA | -1.56e+00 | 0.0e+00 | CDKN1A,CXCR4,FKBP5,IP6K3,LGALS3,MLXIPL,PER1,PGF,POSTN,Slco1a4,USP2 | 59 (12) |
| PRL | 1.00e-01 | cytokine | NA | -1.56e+00 | 1.0e-02 | AEN,CCND1,CDKN1A,ERBB3,FOS,HELZ2,ID2,LAMP3 | NA |
| DNMT3A | -3.00e-01 | enzyme | NA | -1.57e+00 | 0.0e+00 | ADORA1,CXCR4,CYBB,Mt1,MYH6,PIK3C2B,TLR4,USP2 | 53 (7) |
| LEP | -1.00e-02 | growth factor | NA | -1.57e+00 | 0.0e+00 | CCND1,CDKN1A,CYBB,EHHADH,FOS,IL1R2,Irgm1,MLXIPL,NCF1,NOTCH4,PNPLA2,TNFRSF11B | 90 (25) |
| IFI16 | -1.00e-01 | transcription regulator | NA | -1.60e+00 | 0.0e+00 | CCND1,CDKN1A,CSF3R,ID2,NFKBIA | 109 (25) |
| GATA4 | 1.00e-02 | transcription regulator | NA | -1.62e+00 | 0.0e+00 | ADORA1,CA12,CXCR4,FOS,GJA5,LCN2,MYH6,NOTCH4,PLIN4,POSTN | 13 (3) |
| cytokine | NA | group | NA | -1.63e+00 | 0.0e+00 | ADAMTS4,CCND1,CD93,FOS,SGK1,SLC2A1,TLR2,TLR4 | 69 (18) |
| NC410 | NA | biologic drug | NA | -1.63e+00 | 0.0e+00 | CDKN1A,FOS,GBP5,IL1R2,Mt1,RGS1 | NA |
| IRF3 | -2.00e-02 | transcription regulator | NA | -1.63e+00 | 0.0e+00 | CDH11,GBP5,HELZ2,Ifi47,Irgm1,LCN2,TLR4 | 80 (17) |
| VCAN | 7.00e-02 | other | NA | -1.63e+00 | 0.0e+00 | CDKN1A,CXCL12,LCN2,LGALS3,NFKBIA,TGFB3 | 65 (15) |
| cholesterol | NA | chemical - endogenous mammalian | NA | -1.65e+00 | 0.0e+00 | CCR5,CYBB,DBI,INSIG1,KITLG,LGALS3,PTCH1,TLR4 | 94 (14) |
| cardiotoxin | NA | chemical - other | NA | -1.67e+00 | 0.0e+00 | CCND1,CCR5,CD180,CSF3R,CXCR4,Klra2,LCN2,LY86,MERTK,SERPINB10,TNFRSF11B | NA |
| WNT3A | -1.30e-01 | cytokine | NA | -1.67e+00 | 0.0e+00 | ADAMTS4,AHR,Casp12,CCND1,CXCL12,ERBB3,GADD45G,Irgm1,KITLG,LCN2,MYH6,RASGRP3,RUNX1T1,TGFB3,TNFRSF11B,WNT7A | 99 (18) |
| APC | -2.60e-01 | enzyme | NA | -1.67e+00 | 0.0e+00 | CCND1,CDKN1A,CXCL12,DHRS9,ID2,LFNG,SGK1,TNFRSF11B | 97 (20) |
| mir-223 | NA | microRNA | NA | -1.67e+00 | 0.0e+00 | CARD11,CCND1,CD180,CD93,ID2,POSTN,SLC40A1,TLR4 | NA |
| GH1 | NA | growth factor | NA | -1.67e+00 | 0.0e+00 | CXCR4,DBI,ERBB3,FOS,ID2,RPL6 | 81 (19) |
| levothyroxine | NA | chemical - endogenous mammalian | NA | -1.69e+00 | 1.0e-02 | CDKN1A,FOS,MLXIPL,MYH6 | 86 (24) |
| CD40LG | 0.00e+00 | cytokine | NA | -1.69e+00 | 0.0e+00 | AHR,CCR5,CDKN1A,CXCR4,FOS,ID2,LAMP3,NFKBIA,PLEK,RGS1,TNFRSF11A,TNFRSF11B | 102 (19) |
| buthionine sulfoximine | NA | chemical drug | NA | -1.70e+00 | 0.0e+00 | CCR5,CXCR4,FOS,NFKBIA | 94 (20) |
| SOX11 | -3.10e-01 | transcription regulator | NA | -1.70e+00 | 4.0e-02 | ADAMTS4,CCND1,CXCR4,POSTN | NA |
| quercetin | NA | chemical drug | NA | -1.71e+00 | 2.0e-02 | Casp12,CDKN1A,FOS,FZD10,LCN2,TNFRSF11A | NA |
| ESR1 | 5.00e-02 | ligand-dependent nuclear receptor | NA | -1.73e+00 | 3.0e-02 | ADORA1,CA12,CCND1,CDKN1A,COL13A1,CXCL12,ERBB3,FOS,GADD45G,HOMER3,IRAK2,LCN2,NFE2L3,NFKBIA,PTCH1,SGK1,SLC26A2,SLC2A12,SLCO1C1,TGFB3,TNFRSF11B | NA |
| PRNP | 5.00e-02 | other | NA | -1.73e+00 | 1.0e-02 | AHR,CCND1,ID2,NFKBIA | 71 (16) |
| CpG ODN 1826 | NA | chemical reagent | NA | -1.73e+00 | 1.0e-02 | CYBB,NCF1,RGS1,TLR4 | NA |
| REL | -3.90e-01 | transcription regulator | NA | -1.74e+00 | 1.0e-02 | AHR,CCND1,CDKN1A,FOS,INSC,NFKBIA,NRARP | 88 (20) |
| HMGA1 | 1.00e-02 | transcription regulator | NA | -1.76e+00 | 1.0e-02 | CCND1,CRYAB,FOS,INSIG1,KITLG,SLC26A2 | 33 (7) |
| sphingosine-1-phosphate | NA | chemical - endogenous mammalian | NA | -1.76e+00 | 0.0e+00 | ACER2,AHR,CCND1,FOS,GALNT15,GBP5,ID2,ISLR2,TNFRSF11B | 93 (20) |
| ETV5 | -2.30e-01 | transcription regulator | NA | -1.80e+00 | 0.0e+00 | CCND1,CDKN1A,CXCL12,CXCR4,CYBB,LAMP3,LCN2,LGALS3,NFKBIA,RGS1,SFTPB,SLC34A2 | 77 (13) |
| GFI1 | 1.00e-02 | transcription regulator | NA | -1.80e+00 | 0.0e+00 | CDKN1A,CXCR4,GADD45G,ID2,IRAK2,NFKBIA,SGK1,TESC | 97 (24) |
| PTPN11 | 3.30e-01 | phosphatase | NA | -1.80e+00 | 0.0e+00 | CCND1,CDKN1A,CSF3R,CYBB,FOS,SFTPB | 90 (23) |
| genistein | NA | chemical drug | NA | -1.82e+00 | 1.0e-02 | CCND1,CDKN1A,CXCL12,FOS,ID2,LY86,Mt1,PER1,TGFB3,TNFRSF11B | 92 (24) |
| TCF7L2 | -4.30e-01 | transcription regulator | NA | -1.83e+00 | 0.0e+00 | ADAMTS4,ASPA,CCND1,CDKN1A,CSF3R,EHHADH,ERBB3,FOS,ID2,RSPO2,SGK1 | 92 (20) |
| estrogen receptor | NA | group | NA | -1.84e+00 | 0.0e+00 | CA12,CCND1,CDH11,COL13A1,CXCL12,CXCR4,ERBB3,FOS,TGFB3,TLR4 | 104 (22) |
| IL33 | 2.80e-01 | cytokine | NA | -1.85e+00 | 2.0e-02 | CCND1,CSF3R,ID2,NFKBIA,P4HA1,RGS1,SLC19A3,TGFB3,TLR2 | NA |
| CDKN1B | -4.00e-02 | kinase | NA | -1.91e+00 | 3.0e-02 | CA6,CCND1,CDKN1A,LGALS3 | NA |
| N-nitro-L-arginine methyl ester | NA | chemical drug | NA | -1.91e+00 | 0.0e+00 | CCR5,CYBB,INSIG1,NFKBIA,SLC2A1,TLR2,TLR4 | 111 (20) |
| ILF3 | 8.00e-02 | transcription regulator | NA | -1.92e+00 | 1.0e-02 | FKBP5,FOS,ID2,LGALS3 | NA |
| KLF5 | -3.40e-01 | transcription regulator | NA | -1.93e+00 | 2.0e-02 | CCND1,CDKN1A,CXCL12,CXCR4 | NA |
| STAT5B | -6.00e-02 | transcription regulator | NA | -1.93e+00 | 0.0e+00 | CCND1,CDKN1A,FMO2,FOS,GPD1,H2-T22,MYH6,SLC34A2,Slco1a4,TLR2,TNFRSF11A | 78 (19) |
| TAC1 | 1.70e-01 | other | NA | -1.94e+00 | 0.0e+00 | CXCR4,FOS,KITLG,PTCH1,TNFRSF11B | 82 (20) |
| EBF1 | -1.20e-01 | transcription regulator | NA | -1.94e+00 | 6.0e-02 | CXCL12,POSTN,TLR2,TLR4 | NA |
| lipoteichoic acid | NA | chemical - endogenous non-mammalian | NA | -1.96e+00 | 0.0e+00 | CCR5,CXCR4,CYBB,TLR2,TLR4,TNFRSF11B | 81 (17) |
| GW9662 | NA | chemical reagent | NA | -1.97e+00 | 2.0e-02 | CDKN1A,FOS,INSIG1,LCN2 | NA |
| caffeine | NA | chemical drug | NA | -1.98e+00 | 0.0e+00 | CDKN1A,FOS,SFTPB,SLC2A1 | 81 (21) |
| PTK2 | -9.00e-02 | kinase | NA | -1.98e+00 | 0.0e+00 | CCND1,CDKN1A,FOS,MYH6,P4HA1 | 87 (23) |
| 25-hydroxycholesterol | NA | chemical reagent | NA | -1.98e+00 | 0.0e+00 | CCND1,FOS,INSIG1,NFKBIA,PTCH1 | 79 (18) |
| KDM5B | -6.00e-02 | transcription regulator | NA | -1.98e+00 | 5.0e-02 | CCND1,ERBB3,ID2,INSIG1 | NA |
| lipoarabinomannan | NA | chemical - endogenous non-mammalian | Inhibited | -2.00e+00 | 0.0e+00 | CCR5,CXCR4,ERBB3,TLR4 | NA |
| Hbb-b2 | NA | other | Inhibited | -2.00e+00 | 0.0e+00 | CCR5,CYBB,LY86,TLR2 | NA |
| IFNA4 | NA | cytokine | Inhibited | -2.00e+00 | 0.0e+00 | GBP5,H2-T22,Irgm1,PIK3AP1 | NA |
| USP22 | 8.00e-02 | peptidase | Inhibited | -2.00e+00 | 0.0e+00 | CDKN1A,CSF3R,CYBB,MERTK,NCF1 | 43 (7) |
| TCF20 | -2.20e-01 | transcription regulator | Inhibited | -2.00e+00 | 0.0e+00 | GALNT15,LFNG,RSPO2,SGK1 | NA |
| ITPR2 | -4.00e-02 | ion channel | Inhibited | -2.00e+00 | 0.0e+00 | CD180,Ifi47,Irgm1,NCF1 | NA |
| ZBTB10 | -1.70e-01 | transcription regulator | Inhibited | -2.00e+00 | 6.0e-02 | CYBB,GBP5,Ifi47,Irgm1 | NA |
| ethanol | NA | chemical - endogenous mammalian | Inhibited | -2.10e+00 | 0.0e+00 | CCND1,CDKN1A,CXCL12,CXCR4,FOS,Ifi47,IL1R2,MLXIPL,NCF1,NR0B1,PNPLA2,SGK1,SLC40A1,TGFB3,TLR2,TLR4 | 81 (22) |
| VEGFA | -1.30e-01 | growth factor | Inhibited | -2.12e+00 | 0.0e+00 | CCND1,CDKN1A,CXCL12,CXCR4,FOS,NOTCH4,PNPLA2,RASGRP3,SFTPB,STARD8 | 83 (24) |
| ERK1/2 | NA | group | Inhibited | -2.12e+00 | 1.0e-02 | CCND1,CDKN1A,CXCR4,CYBB,FKBP5,FOS,POSTN,SGK1 | 99 (22) |
| THRA | 2.30e-01 | ligand-dependent nuclear receptor | Inhibited | -2.13e+00 | 0.0e+00 | CCND1,CDKN1A,EHHADH,FOS,FZD9,MYH6,NCF1 | 81 (22) |
| CALCA | NA | other | Inhibited | -2.16e+00 | 1.0e-02 | CXCR4,FOS,ID2,NFKBIA,PHLDB2,TGFB3 | 99 (19) |
| SNAI2 | -2.40e-01 | transcription regulator | Inhibited | -2.20e+00 | 0.0e+00 | CCND1,CDKN1A,CXCL12,CXCR4,MYBPH | 83 (20) |
| TEAD1 | -1.00e-01 | transcription regulator | Inhibited | -2.20e+00 | 2.0e-02 | CCND1,CDKN1A,MYH6,POSTN,SH3D19 | NA |
| SOX4 | NA | transcription regulator | Inhibited | -2.21e+00 | 4.0e-02 | ADAMTS4,CXCL12,FOS,MEX3A,Mt1 | NA |
| IRF7 | -3.50e-01 | transcription regulator | Inhibited | -2.22e+00 | 2.0e-02 | GBP5,HELZ2,Ifi47,Irgm1,TLR4 | NA |
| MIF | NA | cytokine | Inhibited | -2.22e+00 | 1.0e-02 | CCND1,CCR5,CXCR4,FOS,TLR4 | NA |
| finerenone | NA | chemical drug | Inhibited | -2.24e+00 | 0.0e+00 | IP6K3,LCN2,LGALS3,PER1,USP2 | NA |
| SFTPC | -3.60e-01 | other | Inhibited | -2.24e+00 | 0.0e+00 | CDKN1A,LAMP3,LGALS3,SFTPB,SLC34A2 | NA |
| CCL20 | NA | cytokine | Inhibited | -2.24e+00 | 0.0e+00 | CYBB,GBP5,NCF1,POSTN,TLR4 | 59 (7) |
| Hbb-b1 | NA | transporter | Inhibited | -2.24e+00 | 0.0e+00 | CCR5,CYBB,LY86,Mt1,TLR2 | 54 (7) |
| IL15 | 1.30e-01 | cytokine | Inhibited | -2.32e+00 | 3.0e-02 | AHR,CCND1,CDKN1A,CXCL12,CXCR4,HMCN1,NFKBIA,PLEK,TLR2 | NA |
| MECP2 | -5.00e-02 | transcription regulator | Inhibited | -2.39e+00 | 0.0e+00 | DOCK8,FKBP5,GALNT15,LFNG,Mt1,RSPO2,SGK1 | 7 (2) |
| Jnk | NA | group | Inhibited | -2.40e+00 | 2.0e-02 | CCND1,CXCL12,CXCR4,FOS,NCF1,POSTN | NA |
| dimethyl sulfoxide | NA | chemical drug | Inhibited | -2.40e+00 | 0.0e+00 | CNR2,FOS,LCN2,MYH6,NCF1,TNFRSF11B | 90 (20) |
| MYB | NA | transcription regulator | Inhibited | -2.40e+00 | 1.0e-02 | CCND1,CXCL12,CXCR4,KITLG,LCN2,SLC16A4 | 75 (17) |
| IHH | 1.10e-01 | enzyme | Inhibited | -2.61e+00 | 0.0e+00 | CCND1,GPR34,PLIN4,PLIN5,POSTN,PTCH1,SLC26A2,TNFRSF11B | NA |
| D-glucose | NA | chemical - endogenous mammalian | Inhibited | -2.93e+00 | 0.0e+00 | Casp12,CCND1,CDKN1A,CXCR4,CYBB,DBI,EVA1A,FOS,GPD1,MLXIPL,Mt1,NCF1,SGK1,SLC16A4,SLC2A1,TGFB3,TLR2,TLR4 | 93 (22) |
| ACOX1 | 6.00e-02 | enzyme | Inhibited | -2.97e+00 | 0.0e+00 | ACER2,CDKN1A,CXCL12,EHHADH,LCN2,LGALS3,PEX11A,RBM3,SGK1 | 81 (13) |
| LDLR | 3.20e-01 | transporter | NA | NA | 0.0e+00 | AURKB,CCND1,CCR5,CDKN1A,DHRS9,GADD45G,GJA5,LCN2,LY86,MERTK,RGS1,SLC2A1,UHRF1,WNT7A | 99 (22) |
| TCL1A | NA | transcription regulator | NA | NA | 0.0e+00 | C1QB,CSF3R,CYBB,FKBP5,FOS,IL1R2,LCN2,RGS1,SLC40A1 | 52 (7) |
| MAPT | -3.00e-02 | other | NA | NA | 0.0e+00 | C1QB,CCND1,CDKN1A,CYBB,DBI,ELOVL7,ENDOU,FOS,GALNT15,GBP5,H2BC5,Irgm1,LCN2,LY86,MCM10,PLIN4,RNF213,TLR2,TMEM212 | 92 (20) |
| Histone h3 | NA | group | NA | NA | 0.0e+00 | CCND1,CDKN1A,FKBP5,FOS,ID2,Mt1,NCF1,NFKBIA,NRARP,PER1,POU2F3,PTCH1,RPL10A,RUNX1T1,SFTPB,SGK1,TLR2 | 100 (20) |
| omeprazole | NA | chemical drug | NA | NA | 0.0e+00 | ADORA1,CDKN1A,CXCL12,CXCR4,FOS,PRRX2 | NA |
| nor-binaltorphimine | NA | chemical reagent | NA | NA | 0.0e+00 | CCR5,CYBB,FOS | 43 (7) |
| MAFA | -1.20e-01 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,CXCL12,CXCR4,ERBB3,ID2,LGALS3,PLCB2,SLC5A10,ZNF189 | NA |
| NR1H3 | 2.00e-02 | ligand-dependent nuclear receptor | NA | NA | 0.0e+00 | AURKB,CCR5,CDKN1A,DHRS9,LY86,MERTK,MLXIPL,Mt1,NFKBIA,PTCH1,UHRF1 | 48 (7) |
| U 50488H | NA | chemical reagent | NA | NA | 0.0e+00 | CCR5,CYBB,FOS | 88 (22) |
| POLR2A | -1.50e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,CDKN1A,CXCR4,FOS,NFKBIA,SGK1 | 72 (11) |
| CSNK1A1 | 1.20e-01 | kinase | NA | NA | 0.0e+00 | CCND1,CDKN1A,CXCR4 | 92 (17) |
| LIPE | 3.00e-01 | enzyme | NA | NA | 0.0e+00 | CLK1,FKBP5,FOS,ID2,KITLG,PER1,PLIN5,POSTN | 46 (7) |
| ACER3 | -1.30e-01 | enzyme | NA | NA | 0.0e+00 | ACER2,CDKN1A | NA |
| KR 62436 | NA | chemical reagent | NA | NA | 0.0e+00 | CXCL12,CXCR4 | NA |
| NSC 651016 | NA | chemical reagent | NA | NA | 0.0e+00 | CCR5,CXCR4 | NA |
| DBH-AS1 | NA | other | NA | NA | 0.0e+00 | CCND1,CDKN1A,SLC2A1 | 57 (12) |
| NQO2 | -1.80e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,CXCL12,CXCR4 | 83 (17) |
| CD5L | -8.00e-02 | transmembrane receptor | NA | NA | 0.0e+00 | LCN2,TLR2,TLR4 | NA |
| PEBP4 | -1.00e-02 | other | NA | NA | 0.0e+00 | CDKN1A,NFKBIA,TLR4 | 44 (7) |
| Mt1 | 1.83e+00 | other | NA | NA | 0.0e+00 | CCND1,FOS,Mt1,NFKBIA | 82 (13) |
| clioquinol | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CDKN1A,FOS | 87 (18) |
| H2AZ1 | NA | other | NA | NA | 0.0e+00 | AURKB,CCND1,CDKN1A,CXCR4,WNT7A | NA |
| CDK9 | 6.00e-02 | kinase | NA | NA | 0.0e+00 | CDKN1A,CXCR4,FOS,H2BC5,NFKBIA | 84 (16) |
| putrescine | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CDKN1A,FOS,TLR2 | NA |
| SERPINF1 | -1.90e-01 | other | NA | NA | 0.0e+00 | CCND1,CRYAB,CYBB,NFKBIA,TNFRSF11B | 53 (10) |
| CRY2 | 1.80e-01 | enzyme | NA | NA | 0.0e+00 | FOS,PER1,SGK1 | 39 (6) |
| CRY1 | 2.60e-01 | enzyme | NA | NA | 0.0e+00 | FOS,PER1,SGK1 | 39 (7) |
| gamma-linolenic acid | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | NCF1,PLIN4,PLIN5 | NA |
| GY1-22 | NA | chemical reagent | NA | NA | 0.0e+00 | CCND1,CDKN1A | NA |
| L-ornithine | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CDKN1A,PNPLA2 | NA |
| GPC6 | -8.00e-02 | transmembrane receptor | NA | NA | 0.0e+00 | CCND1,PTCH1 | NA |
| OLA1 | 1.40e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,CDKN1A | 63 (7) |
| bis(4-hydroxycinnamoyl)methane | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | TLR2,TLR4 | NA |
| ELL | 1.30e-01 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,FOS | 58 (14) |
| U2AF2 | 7.00e-02 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | 56 (13) |
| ATOX1 | 4.00e-01 | transporter | NA | NA | 0.0e+00 | CCND1,NCF1 | NA |
| RASSF7 | 1.00e-01 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | NA |
| mizoribine | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,SGK1 | NA |
| xanthine | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CCR5,CXCR4,SLC2A1 | 66 (14) |
| RPL13A | 4.40e-01 | other | NA | NA | 0.0e+00 | CDKN1A,CXCL12,LCN2 | 58 (7) |
| CBX2 | -2.90e-01 | transcription regulator | NA | NA | 0.0e+00 | AHR,CDKN1A,NR0B1 | NA |
| LCOR | NA | transcription regulator | NA | NA | 0.0e+00 | ADORA1,CDKN1A,FKBP5 | NA |
| WNT3 | 1.60e-01 | other | NA | NA | 0.0e+00 | CDKN1A,POSTN,PTCH1 | 44 (7) |
| Cd2+ | NA | chemical toxicant | NA | NA | 0.0e+00 | CCND1,FOS,Mt1 | 75 (16) |
| NAE1 | 1.20e-01 | enzyme | NA | NA | 0.0e+00 | AURKB,CCND1,CDKN1A | 72 (12) |
| SP2 | 4.30e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A,FOS | NA |
| CTSK | -3.00e-02 | peptidase | NA | NA | 0.0e+00 | CDKN1A,TLR2,TLR4 | NA |
| GTF2I | -1.60e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A,FOS | 70 (15) |
| DEK | 2.00e-02 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,CSF3R,NFKBIA | NA |
| ACKR3 | 0.00e+00 | G-protein coupled receptor | NA | NA | 0.0e+00 | CCND1,CDKN1A,CXCL12,CXCR4 | 83 (23) |
| RBCK1 | -4.00e-02 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CXCR4,GBP5,NFKBIA | 73 (16) |
| RNA polymerase II | NA | complex | NA | NA | 0.0e+00 | CA12,CDH11,CDKN1A,CXCR4,FOS,Ifi47,KITLG,Mt1,NFKBIA,RPL10A | 73 (10) |
| NKX2-1 | -3.00e-02 | transcription regulator | NA | NA | 0.0e+00 | GRHL2,KITLG,LCN2,MYBPH,PRRX2,ROR1,SFTPB,SLC34A2 | NA |
| FGFR4 | -2.30e-01 | kinase | NA | NA | 0.0e+00 | CCND1,CDKN1A,FOS,MLXIPL | 90 (26) |
| vatalanib | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CDKN1A,CXCL12 | 83 (21) |
| Raf | NA | group | NA | NA | 0.0e+00 | CCND1,CDKN1A,FOS,ID2,STON1 | 93 (25) |
| desoxycorticosterone | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CCR5,CYBB,FOS | 33 (7) |
| bevacizumab | NA | biologic drug | NA | NA | 0.0e+00 | CXCL12,CXCR4,PGF | 64 (11) |
| triclosan | NA | chemical drug | NA | NA | 0.0e+00 | CYBB,FOS,NCF1 | 47 (7) |
| Integrin | NA | complex | NA | NA | 0.0e+00 | AHR,CCND1,FOS | 80 (22) |
| DDX17 | NA | enzyme | NA | NA | 0.0e+00 | CCND1,CDKN1A,LCN2 | 64 (7) |
| zearalenone | NA | chemical toxicant | NA | NA | 0.0e+00 | CCND1,KITLG,TLR4 | 31 (5) |
| L-alanine | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CCND1,CDKN1A | 63 (5) |
| inecalcitol | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CDKN1A | 67 (19) |
| CINP | 2.20e-01 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | NA |
| DNAJB4 | 1.00e-02 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | 80 (21) |
| TEX11 | -3.00e-02 | other | NA | NA | 0.0e+00 | CCND1,FOS | 65 (12) |
| MUCL1 | NA | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | 56 (12) |
| pertuzumab | NA | biologic drug | NA | NA | 0.0e+00 | CCND1,CDKN1A | 58 (9) |
| firtecan pegol | NA | chemical drug | NA | NA | 0.0e+00 | CXCR4,SLC2A1 | NA |
| AHNAK | -3.20e-01 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | 59 (13) |
| NASP | -8.00e-02 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | 47 (7) |
| CPT2 | 2.70e-01 | enzyme | NA | NA | 0.0e+00 | EHHADH,ELOVL7 | NA |
| PTCH2 | NA | transmembrane receptor | NA | NA | 0.0e+00 | CXCL12,KITLG | NA |
| AKAP13 | -3.10e-01 | other | NA | NA | 0.0e+00 | FKBP5,FOS | 43 (7) |
| S100A11 | 9.00e-02 | other | NA | NA | 0.0e+00 | ADAMTS4,CDKN1A | NA |
| TXN2 | 2.50e-01 | enzyme | NA | NA | 0.0e+00 | CYBB,NCF1 | NA |
| carboxyamido-triazole | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,FOS | 79 (21) |
| salsalate | NA | chemical drug | NA | NA | 0.0e+00 | NCF1,NFKBIA | NA |
| MMP2 | -3.00e-02 | peptidase | NA | NA | 0.0e+00 | CCND1,CDKN1A,CXCL12,INSIG1,MLXIPL | 101 (22) |
| histone deacetylase | NA | complex | NA | NA | 0.0e+00 | CCND1,CXCR4,ID2,PER1 | 69 (15) |
| PLC | NA | group | NA | NA | 0.0e+00 | FOS,TNFRSF11A,TNFRSF11B | 96 (26) |
| YY2 | NA | transcription regulator | NA | NA | 0.0e+00 | CXCR4,FOS,MYH6 | NA |
| magnolol | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | CDKN1A,FOS,TLR4 | 95 (26) |
| CX3CL1 | -5.00e-02 | cytokine | NA | NA | 0.0e+00 | ASPA,CCND1,CXCL12,ERBB3,ID2,POSTN,TGFB3 | 85 (16) |
| thiostrepton | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | AURKB,CCND1,MCM10 | 68 (6) |
| CSF3R | -6.70e-01 | transmembrane receptor | NA | NA | 0.0e+00 | CSF3R,CXCL12,FOS | NA |
| MUC4 | NA | other | NA | NA | 0.0e+00 | CCND1,CDKN1A,ERBB3 | 91 (25) |
| metyrapone | NA | chemical drug | NA | NA | 0.0e+00 | CXCL12,CXCR4,FOS | NA |
| STK40 | -3.10e-01 | kinase | NA | NA | 0.0e+00 | C1QB,CCR5,SFTPB,TLR4,WNT7A | NA |
| RBL1 | -4.30e-01 | transcription regulator | NA | NA | 0.0e+00 | AURKB,CCND1,CDKN1A,FOS,MCM10 | 101 (21) |
| ursolic acid | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CDKN1A,CXCR4,FOS,TLR4 | 79 (20) |
| PLCG1 | -6.00e-02 | enzyme | NA | NA | 0.0e+00 | CCND1,FOS,SLC2A1 | 87 (24) |
| HGS | 1.00e-01 | other | NA | NA | 0.0e+00 | ERBB3,FOS,POU3F2 | 46 (7) |
| NAB2 | -1.10e-01 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,FOS,ID2 | 32 (5) |
| L-aspartic acid | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CCND1,CDKN1A | 63 (5) |
| Integrinα | NA | group | NA | NA | 0.0e+00 | TLR2,TLR4 | NA |
| Gpcr | NA | group | NA | NA | 0.0e+00 | FOS,RGS1 | NA |
| SLC39A4 | 1.30e-01 | transporter | NA | NA | 0.0e+00 | CCND1,Mt1 | 46 (7) |
| CALCR | 1.80e-01 | G-protein coupled receptor | NA | NA | 0.0e+00 | CDKN1A,FOS | 77 (20) |
| FLOT1 | 1.10e-01 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | 80 (19) |
| RBBP8 | -6.00e-02 | enzyme | NA | NA | 0.0e+00 | CCND1,CDKN1A | NA |
| N-hydroxy-N’-(4-butyl-2-methylphenyl)formamidine | NA | chemical reagent | NA | NA | 0.0e+00 | CYBB,NCF1 | NA |
| silicon phthalocyanine | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CDKN1A | 76 (13) |
| Ras homolog | NA | group | NA | NA | 0.0e+00 | CCND1,CDKN1A,FOS | 95 (23) |
| MAP3K5 | -1.00e-02 | kinase | NA | NA | 0.0e+00 | CCND1,CDKN1A,CYBB | 87 (22) |
| TERF2IP | 6.40e-01 | other | NA | NA | 0.0e+00 | CA6,NFKBIA,NUDT6 | NA |
| HTT | -1.60e-01 | transcription regulator | NA | NA | 0.0e+00 | ADAMTS4,CA12,CCND1,CDH11,CDKN1A,CNR2,CRYAB,FOS,GADD45G,Mt1,PER1,SGK1,SLC2A1,SLC40A1,TESC,USP2 | 99 (23) |
| betamethasone | NA | chemical drug | NA | NA | 0.0e+00 | ASPA,HIF3A,SFTPB | NA |
| NADPH oxidase | NA | complex | NA | NA | 0.0e+00 | CYBB,FOS,NCF1 | 57 (12) |
| G6PC3 | 2.00e-02 | phosphatase | NA | NA | 0.0e+00 | CYBB,NCF1 | NA |
| vaccenic acid | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | PLIN4,PLIN5 | NA |
| PLSCR1 | -2.20e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,CDKN1A | 57 (13) |
| BCL2L12 | 6.00e-02 | other | NA | NA | 0.0e+00 | CDKN1A,CRYAB | 63 (7) |
| Nisch | NA | other | NA | NA | 0.0e+00 | FOS,MLXIPL | 61 (12) |
| DYNLL1 | 3.00e-02 | other | NA | NA | 0.0e+00 | CDKN1A,FOS | 68 (14) |
| ECT2 | -2.00e-02 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | 65 (13) |
| CDH13 | 1.50e-01 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | 85 (20) |
| CXXC4 | -2.10e-01 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | 57 (7) |
| dibenzoylmethane | NA | chemical toxicant | NA | NA | 0.0e+00 | CCND1,CDKN1A | 90 (18) |
| L-asparagine | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CCND1,CDKN1A | 61 (12) |
| RNASEH2A | 9.00e-02 | enzyme | NA | NA | 0.0e+00 | H2BC5,NFKBIA,TLR2,TLR4 | NA |
| TEAD2 | -1.40e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,POSTN,SH3D19,UHRF1 | NA |
| romidepsin | NA | biologic drug | NA | NA | 0.0e+00 | CCND1,CDKN1A,FOS,GADD45G,SLC26A2 | 93 (25) |
| ADCY | NA | group | NA | NA | 0.0e+00 | CDKN1A,FOS,PER1 | 83 (21) |
| calpain | NA | complex | NA | NA | 0.0e+00 | CCND1,NFKBIA,TLR4 | 67 (18) |
| GDF15 | 1.00e-02 | growth factor | NA | NA | 0.0e+00 | CCND1,CDKN1A,PNPLA2 | 60 (12) |
| ACVR1C | -2.10e-01 | kinase | NA | NA | 0.0e+00 | CCND1,CDKN1A,FOS | 95 (25) |
| LGALS9 | NA | other | NA | NA | 0.0e+00 | CCR5,CDKN1A,CXCR4 | NA |
| POLR2M | 8.00e-02 | other | NA | NA | 0.0e+00 | AEN,CCND1,CDKN1A | NA |
| GHRH | 5.60e-01 | other | NA | NA | 0.0e+00 | CCND1,FOS,KITLG | 79 (22) |
| LMNB1 | -9.00e-02 | other | NA | NA | 0.0e+00 | CRYAB,CXCL12,ELOVL7,PRRX2 | NA |
| TCF | NA | group | NA | NA | 0.0e+00 | CCND1,FOS,LGALS3,PTCH1,SLC26A2 | 68 (9) |
| MTORC1 | NA | complex | NA | NA | 0.0e+00 | AHR,CCND1,INSIG1,SLC2A1 | 44 (9) |
| BPIFB1 | 2.00e-02 | other | NA | NA | 0.0e+00 | CCND1,NFKBIA,SLC2A1 | 59 (12) |
| SLC2A4 | 0.00e+00 | transporter | NA | NA | 0.0e+00 | MLXIPL,SLC2A1,SLC2A12 | NA |
| MAP3K3 | -7.00e-02 | kinase | NA | NA | 0.0e+00 | FOS,POSTN,TGFB3 | 82 (23) |
| HEXIM1 | -1.10e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A,SLC2A1 | 86 (19) |
| TAF4B | 1.80e-01 | transcription regulator | NA | NA | 0.0e+00 | NFKBIA,TGFB3,ZBTB16 | NA |
| SRD5A1 | -2.00e-02 | enzyme | NA | NA | 0.0e+00 | LCN2,Mt1,PNPLA2 | NA |
| IOX2 | NA | chemical reagent | NA | NA | 0.0e+00 | CARD11,P4HA1,SLC2A1 | NA |
| H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one | NA | chemical reagent | NA | NA | 0.0e+00 | CDKN1A,FOS,TLR4 | 80 (23) |
| OSMI-1 | NA | chemical reagent | NA | NA | 0.0e+00 | CCND1,CDKN1A | 56 (11) |
| Calcineurin B | NA | group | NA | NA | 0.0e+00 | CCR5,CDKN1A | NA |
| ZNF100 | NA | transcription regulator | NA | NA | 0.0e+00 | POSTN,TGFB3 | NA |
| PRDM4 | -1.60e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A | 51 (7) |
| ZNF85 | NA | transcription regulator | NA | NA | 0.0e+00 | POSTN,TGFB3 | NA |
| ZNF254 | NA | transcription regulator | NA | NA | 0.0e+00 | POSTN,TGFB3 | NA |
| RASSF8 | -8.00e-02 | other | NA | NA | 0.0e+00 | POSTN,TGFB3 | NA |
| ZNF431 | NA | transcription regulator | NA | NA | 0.0e+00 | POSTN,TGFB3 | NA |
| RAP1GAP | 4.00e-02 | other | NA | NA | 0.0e+00 | CCND1,FOS | 100 (26) |
| DAB2 | -4.40e-01 | other | NA | NA | 0.0e+00 | CCND1,FOS | 82 (23) |
| PDE3A | -2.40e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,CDKN1A | 64 (12) |
| ZNF665 | 2.00e-02 | other | NA | NA | 0.0e+00 | POSTN,TGFB3 | NA |
| ZNF528 | NA | other | NA | NA | 0.0e+00 | POSTN,TGFB3 | NA |
| BANCR | NA | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | 79 (17) |
| ZNF43 | -2.30e-01 | transcription regulator | NA | NA | 0.0e+00 | POSTN,TGFB3 | NA |
| ZNF429 | NA | transcription regulator | NA | NA | 0.0e+00 | POSTN,TGFB3 | NA |
| GAS1 | -1.90e-01 | other | NA | NA | 0.0e+00 | CDKN1A,PTCH1 | NA |
| SLCO1B3 | 0.00e+00 | transporter | NA | NA | 0.0e+00 | CDKN1A,Slco1a4 | 16 (4) |
| PLAC8 | NA | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | 43 (7) |
| A939572 | NA | chemical reagent | NA | NA | 0.0e+00 | LCN2,PNPLA2 | NA |
| ZNF708 | NA | other | NA | NA | 0.0e+00 | POSTN,TGFB3 | NA |
| Brd4 | -1.20e-01 | kinase | NA | NA | 0.0e+00 | FOS,NFKBIA | 37 (7) |
| PRN694 | NA | chemical drug | NA | NA | 0.0e+00 | FOS,NFKBIA | 44 (7) |
| diazepam | NA | chemical drug | NA | NA | 0.0e+00 | FOS,PER1 | 66 (11) |
| FOXP3 | 1.60e-01 | transcription regulator | NA | NA | 0.0e+00 | CD101,CDKN1A,CXCR4,FOS,ID2,LGALS3,RGS1 | 98 (18) |
| VH032 | NA | chemical reagent | NA | NA | 0.0e+00 | CARD11,P4HA1,SLC2A1 | NA |
| MTA2 | 6.00e-02 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,ID2,MYH6 | NA |
| SLC9A3 | 2.80e-01 | ion channel | NA | NA | 0.0e+00 | CCND1,Ifi47,Mt1 | 50 (7) |
| TAF4 | NA | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDH11,ID2,MAP3K6,TGFB3 | NA |
| diphtheria toxin | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | ERBB3,FOS,IL1R2,MERTK,TLR2,TNFRSF11A | NA |
| SMARCC1 | -1.20e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A,NR0B1 | 58 (10) |
| L-proline | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CCND1,CDKN1A | 71 (15) |
| Li+ | NA | chemical reagent | NA | NA | 0.0e+00 | CCND1,FOS | 65 (13) |
| N-Cadherin | NA | group | NA | NA | 0.0e+00 | CCND1,CDKN1A | 43 (7) |
| GCS-100 | NA | chemical drug | NA | NA | 0.0e+00 | CDKN1A,LGALS3 | NA |
| LTBP4 | 1.00e-02 | growth factor | NA | NA | 0.0e+00 | ID2,TGFB3 | NA |
| ABCC1 | -3.10e-01 | transporter | NA | NA | 0.0e+00 | CYBB,NCF1 | NA |
| ARHGEF1 | -3.50e-01 | other | NA | NA | 0.0e+00 | CCND1,FOS | 77 (21) |
| evofosfamide | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CDKN1A | NA |
| BANP | -6.10e-01 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | 66 (18) |
| ARAF | 1.00e-02 | kinase | NA | NA | 0.0e+00 | CCND1,FOS | 85 (23) |
| WNT7B | -2.00e-02 | other | NA | NA | 0.0e+00 | CCND1,PTCH1 | NA |
| SNW1 | 2.30e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A | 37 (7) |
| CCX771 | NA | chemical reagent | NA | NA | 0.0e+00 | CXCL12,CXCR4 | 50 (9) |
| ZNF91 | -3.00e-02 | transcription regulator | NA | NA | 0.0e+00 | POSTN,TGFB3 | NA |
| amoxicillin | NA | chemical drug | NA | NA | 0.0e+00 | TLR2,TLR4 | NA |
| temsirolimus | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,SLC2A1 | 57 (12) |
| vandetanib | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CXCR4 | 69 (18) |
| epoxyeicosatrienoic acid analog B | NA | chemical reagent | NA | NA | 0.0e+00 | Casp12,CYBB | NA |
| epoxyeicosatrienoic acid analog A | NA | chemical reagent | NA | NA | 0.0e+00 | Casp12,CYBB | NA |
| JNJ-39933673 | NA | chemical reagent | NA | NA | 0.0e+00 | MLXIPL,TLR4 | NA |
| N-methyl-3,4-methylenedioxyamphetamine | NA | chemical drug | NA | NA | 0.0e+00 | FOS,Mt1 | NA |
| artemisinin | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CDKN1A | 62 (18) |
| mannan | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | TLR2,TLR4 | 44 (9) |
| CYP1A1 | -1.40e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,INSC,KITLG,Mt1,PTP4A3 | NA |
| PG3-Oc | NA | chemical reagent | NA | NA | 0.0e+00 | ACER2,CDKN1A,SLC2A1 | NA |
| PRKDC | -2.60e-01 | kinase | NA | NA | 0.0e+00 | AHR,CCND1,CDKN1A | 82 (22) |
| HEIH | NA | other | NA | NA | 0.0e+00 | FOS,KITLG,TGFB3 | NA |
| CHADL | 1.90e-01 | other | NA | NA | 0.0e+00 | CDKN1A,CRYAB,NCF1 | NA |
| HOXB13 | NA | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A,NFKBIA | 37 (7) |
| GABARAPL2 | 9.00e-02 | other | NA | NA | 0.0e+00 | CRYAB,CXCR4,INSIG1 | NA |
| magnesium | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CDKN1A,HIF3A,TNFRSF11B | 74 (21) |
| methylselenic acid | NA | chemical reagent | NA | NA | 0.0e+00 | CCND1,CDKN1A,FKBP5,ID2,SGK1,TLR2,WNT7A,ZBTB16 | 100 (25) |
| HNRNPA2B1 | -1.70e-01 | other | NA | NA | 0.0e+00 | CA12,ELOVL7,ERBB3,MAST4,P4HA1,ROR1 | NA |
| GABARAPL1 | 2.70e-01 | other | NA | NA | 0.0e+00 | CRYAB,CXCR4,INSIG1 | NA |
| ELOVL5 | -5.00e-02 | enzyme | NA | NA | 0.0e+00 | EHHADH,MLXIPL,PNPLA2 | NA |
| RACK1 | 4.00e-01 | enzyme | NA | NA | 0.0e+00 | CDKN1A,FOS,PTCH1 | 79 (23) |
| GNAI2 | 2.10e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,CCR5,CXCR4 | 97 (22) |
| OSMR | 3.60e-01 | transmembrane receptor | NA | NA | 0.0e+00 | FOS,GBP5,Ifi47,Irgm1 | 67 (12) |
| GNAQ | -1.80e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,CXCL12,FOS,INSIG1,LGALS3,SGK1 | 94 (23) |
| SLC22A5 | 3.00e-01 | transporter | NA | NA | 0.0e+00 | CDKN1A,NR0B1,TGFB3 | NA |
| BMPR2 | -1.10e-01 | kinase | NA | NA | 0.0e+00 | CXCL12,ID2,TNFRSF11B | 63 (11) |
| NR2E1 | -1.40e-01 | ligand-dependent nuclear receptor | NA | NA | 0.0e+00 | CCND1,CDKN1A,WNT7A | 43 (13) |
| MDM4 | -1.60e-01 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,LGALS3,WNT7A | 74 (14) |
| GABARAP | 2.00e-01 | transporter | NA | NA | 0.0e+00 | CRYAB,CXCR4,INSIG1 | NA |
| IDR-1002 | NA | chemical reagent | NA | NA | 0.0e+00 | CSF3R,NCF1,TLR4 | NA |
| DDB1 | -4.00e-02 | other | NA | NA | 0.0e+00 | CDKN1A,FOS,ID2 | 63 (7) |
| pilocarpine | NA | chemical drug | NA | NA | 0.0e+00 | FOS,HOMER3,LGALS3 | 49 (7) |
| bufalin | NA | chemical reagent | NA | NA | 0.0e+00 | CCND1,FOS,GJA5 | 94 (23) |
| DDX5 | 3.00e-02 | enzyme | NA | NA | 0.0e+00 | CCND1,CDKN1A,FOS,LCN2 | 87 (20) |
| SF-3-030 | NA | chemical reagent | NA | NA | 0.0e+00 | AHR,TNFRSF11B | NA |
| Ck2 | NA | complex | NA | NA | 0.0e+00 | CYBB,FOS | 76 (21) |
| MEMO1 | -1.90e-01 | other | NA | NA | 0.0e+00 | CCND1,FOS | 72 (16) |
| ZNF503-AS1 | NA | other | NA | NA | 0.0e+00 | MERTK,RPE65 | NA |
| ZIC2 | -1.40e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,WNT7A | NA |
| MED15 | 5.00e-02 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A | 52 (7) |
| genipin | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | CCND1,CDKN1A | 72 (16) |
| SCN1B | 1.60e-01 | ion channel | NA | NA | 0.0e+00 | FOS,POSTN | NA |
| ING4 | -8.00e-02 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,NFKBIA | 62 (13) |
| PRSS8 | 2.00e-01 | peptidase | NA | NA | 0.0e+00 | CCND1,TLR4 | NA |
| YBX3 | 1.20e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,ERBB3 | NA |
| MPL | 4.00e-02 | transmembrane receptor | NA | NA | 0.0e+00 | FOS,SLC2A1 | 100 (21) |
| GNRH2 | NA | other | NA | NA | 0.0e+00 | CDH11,FOS | 62 (9) |
| cordycepin | NA | chemical drug | NA | NA | 0.0e+00 | ADORA1,FOS | NA |
| PRKG1 | NA | kinase | NA | NA | 0.0e+00 | CCND1,CDKN1A,FOS | 81 (20) |
| PTH1R | -4.00e-02 | G-protein coupled receptor | NA | NA | 0.0e+00 | CCND1,TNFRSF11A,TNFRSF11B | 61 (11) |
| acyline | NA | biologic drug | NA | NA | 0.0e+00 | FOS,GADD45G,RPL10A,RPL6,ZBTB16 | 21 (3) |
| HDAC3 | 1.90e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A,FOS,NFKBIA,SLC2A1 | 66 (16) |
| JUNB | -2.20e-01 | transcription regulator | NA | NA | 0.0e+00 | C1QB,CCND1,ID2,LCN2,PNPLA2,SGK1 | 67 (12) |
| Fgf | NA | group | NA | NA | 0.0e+00 | CCND1,FOS,PER1 | 75 (20) |
| C1QA | 2.40e-01 | other | NA | NA | 0.0e+00 | LCN2,MERTK,TLR4 | 54 (7) |
| HAVCR2 | 1.70e-01 | other | NA | NA | 0.0e+00 | CCR5,CDKN1A,CXCR4 | 59 (11) |
| DHX9 | -1.10e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,ID2,RGS1 | 30 (7) |
| SSRP1 | 1.00e-01 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,ID2,MYH6 | 16 (3) |
| NFIC | -2.50e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A,RPE65 | 77 (13) |
| vitamin A | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | AHR,CDKN1A,SLC40A1 | NA |
| DIO2 | 4.60e-01 | enzyme | NA | NA | 0.0e+00 | ASPA,FOS,GADD45G,PTCH1,RBM3,SLC10A6 | NA |
| NAP1L1 | 9.00e-02 | other | NA | NA | 0.0e+00 | CXCR4,WNT7A | NA |
| HJURP | 5.00e-02 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | 77 (12) |
| TRIM29 | -4.00e-02 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,CXCR4 | NA |
| PF-4457845 | NA | chemical drug | NA | NA | 0.0e+00 | FOS,LCN2 | NA |
| PPM1D | 1.50e-01 | phosphatase | NA | NA | 0.0e+00 | CCND1,CDKN1A | 78 (21) |
| IGF2R | -2.40e-01 | transmembrane receptor | NA | NA | 0.0e+00 | POSTN,TGFB3 | NA |
| ADCY7 | -8.00e-02 | enzyme | NA | NA | 0.0e+00 | IRAK2,TLR4 | NA |
| HCRT | -1.50e-01 | other | NA | NA | 0.0e+00 | FOS,KITLG | NA |
| LOC102724428/SIK1 | NA | kinase | NA | NA | 0.0e+00 | GPD1,NR0B1 | NA |
| ulixertinib | NA | chemical drug | NA | NA | 0.0e+00 | AHR,TNFRSF11B | NA |
| RECK | -1.50e-01 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | 76 (19) |
| PRKCH | -8.00e-02 | kinase | NA | NA | 0.0e+00 | CCND1,CDKN1A | 86 (24) |
| BW 245C | NA | chemical reagent | NA | NA | 0.0e+00 | ENPP3,TNFRSF11B | 19 (3) |
| 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone | NA | chemical reagent | NA | NA | 0.0e+00 | CCND1,CDKN1A | 63 (7) |
| quinidine | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CDKN1A | 42 (9) |
| perilla alcohol | NA | chemical drug | NA | NA | 0.0e+00 | CDKN1A,NFKBIA | 75 (14) |
| N-cor | NA | group | NA | NA | 0.0e+00 | CCND1,CDKN1A,PLA2G3,SGK1,SLC2A1 | 85 (24) |
| Calcineurin A | NA | group | NA | NA | 0.0e+00 | CCND1,FOS,SLC2A1 | 99 (21) |
| Rar | NA | group | NA | NA | 0.0e+00 | CDKN1A,CRYAB,SFTPB | 49 (11) |
| bardoxolone | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CDKN1A,NFKBIA | 69 (13) |
| GNA15 | -4.60e-01 | enzyme | NA | NA | 0.0e+00 | CRYAB,LGALS3,Mt1,PRRX2,TGFB3 | NA |
| bromobenzene | NA | chemical toxicant | NA | NA | 0.0e+00 | CDKN1A,FOS,Mt1,Mt1m/Mt2A | NA |
| indican | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CDKN1A,CXCR4,SLC2A1 | 88 (22) |
| MEIS1 | NA | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,FOS,RGS1 | NA |
| sodium orthovanadate | NA | chemical reagent | NA | NA | 0.0e+00 | CCND1,CDKN1A,NFKBIA | 69 (19) |
| betulinic acid | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CXCL12,TLR4 | 111 (18) |
| eplerenone | NA | chemical drug | NA | NA | 0.0e+00 | CYBB,LGALS3,NCF1 | 31 (4) |
| vitamin D | NA | chemical drug | NA | NA | 0.0e+00 | CDKN1A,NFKBIA,SGK1,TLR4 | 83 (21) |
| RORA | 2.00e-02 | ligand-dependent nuclear receptor | NA | NA | 0.0e+00 | CDKN1A,ELOVL7,LCN2,Mt1,Nat8f5,NFKBIA,Slco1a4 | 74 (11) |
| SP3 | -2.00e-01 | transcription regulator | NA | NA | 0.0e+00 | ADCY4,AFAP1L1,CCND1,CDKN1A,FOS,SGK1,TLR2 | 106 (27) |
| KIT | -1.30e-01 | transmembrane receptor | NA | NA | 0.0e+00 | CXCR4,GPR34,Ifi47,KITLG,LGALS3 | NA |
| L-serine | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CCND1,CDKN1A | 68 (15) |
| TEAD | NA | group | NA | NA | 0.0e+00 | CCND1,POSTN | NA |
| MTF1 | -8.00e-02 | transcription regulator | NA | NA | 0.0e+00 | Mt1,PGF | NA |
| PRPF19 | 2.00e-01 | enzyme | NA | NA | 0.0e+00 | CDKN1A,PLIN4 | NA |
| SNHG20 | NA | other | NA | NA | 0.0e+00 | CCND1,CDKN1A | NA |
| EEF1A2 | 2.10e-01 | translation regulator | NA | NA | 0.0e+00 | CYBB,NCF1 | NA |
| RFC4 | 3.30e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,NRARP | 44 (7) |
| TBC1D1 | 5.00e-02 | other | NA | NA | 0.0e+00 | PLIN4,PLIN5 | NA |
| KLB | 6.00e-02 | enzyme | NA | NA | 0.0e+00 | CCND1,FOS | 70 (17) |
| ELK3 | -4.10e-01 | transcription regulator | NA | NA | 0.0e+00 | FOS,MYH6 | 35 (4) |
| CYBA | 8.00e-02 | enzyme | NA | NA | 0.0e+00 | CDKN1A,CYBB | 82 (16) |
| sesamin | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | NCF1,TNFRSF11B | 40 (7) |
| SS18-SSX2 | NA | fusion gene/product | NA | NA | 0.0e+00 | CCND1,FZD10 | NA |
| adaphostin | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CDKN1A | 80 (21) |
| allopregnanolone | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | FOS,LGALS3 | NA |
| FKBP5 | 1.47e+00 | enzyme | NA | NA | 0.0e+00 | CCND1,CDKN1A,SLC2A1 | 66 (18) |
| NFIL3 | 0.00e+00 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,ID2,PLIN4 | NA |
| PLAT | 1.90e-01 | peptidase | NA | NA | 0.0e+00 | CCND1,FOS,TLR4 | 85 (18) |
| CSNK2A1 | -1.50e-01 | kinase | NA | NA | 0.0e+00 | AHR,CCND1,TGFB3 | 41 (9) |
| trabectedin | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CDKN1A,NR0B1 | 24 (5) |
| SU6656 | NA | chemical toxicant | NA | NA | 0.0e+00 | CCND1,Mt1,TNFRSF11B | 44 (7) |
| honokiol | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | CCND1,CDKN1A,FOS | 103 (24) |
| phorbol 12,13-dibutyrate | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | CD93,CDKN1A,FOS | 99 (25) |
| GNB2 | 1.20e-01 | enzyme | NA | NA | 0.0e+00 | AHR,CDKN1A,IL1R2 | NA |
| NLRP12 | 1.50e-01 | other | NA | NA | 0.0e+00 | CXCL12,CXCR4,TLR4 | 80 (18) |
| EWSR1 | NA | other | NA | NA | 0.0e+00 | CCND1,FOS,NR0B1 | 34 (7) |
| PML-RARA | NA | fusion gene/product | NA | NA | 0.0e+00 | CDKN1A,CYTH4,FOS | NA |
| alvocidib | NA | chemical drug | NA | NA | 0.0e+00 | AEN,CCND1,CDKN1A | 77 (20) |
| sulindac sulfide | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CDKN1A,GADD45G,INSIG1 | 96 (21) |
| PIK3CA | -2.80e-01 | kinase | NA | NA | 1.0e-02 | CCND1,CDH11,CXCL12,CXCR4,NFKBIA,RUNX1T1 | 74 (18) |
| NVP-TAE684 | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,ERBB3,TGFB3 | NA |
| SUMO3 | 2.30e-01 | other | NA | NA | 1.0e-02 | ENPP3,LAMP3,PLA2G3 | NA |
| UBE2I | -9.00e-02 | enzyme | NA | NA | 1.0e-02 | CCND1,SGK1,SLC2A1 | 82 (19) |
| lisinopril | NA | biologic drug | NA | NA | 1.0e-02 | CYBB,FOS,Ifi47 | NA |
| ANTXR2 | -1.60e-01 | transmembrane receptor | NA | NA | 1.0e-02 | CCND1,KITLG | NA |
| highly active antiretroviral therapy | NA | chemical drug | NA | NA | 1.0e-02 | CCR5,CXCR4 | 36 (7) |
| USP28 | -1.90e-01 | peptidase | NA | NA | 1.0e-02 | CCND1,CDKN1A | 102 (23) |
| GADD45G | 9.90e-01 | other | NA | NA | 1.0e-02 | CDKN1A,FOS | 88 (24) |
| CST3 | 2.20e-01 | other | NA | NA | 1.0e-02 | FOS,NFKBIA | 43 (7) |
| PIAS2 | -1.30e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,FOS | 89 (23) |
| RB1CC1 | -2.00e-01 | other | NA | NA | 1.0e-02 | CCND1,CDKN1A | 61 (13) |
| DDB2 | -1.60e-01 | other | NA | NA | 1.0e-02 | CDKN1A,NFKBIA | 88 (20) |
| CCNT1 | 6.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CCND1,SLC2A1 | 35 (7) |
| FOXD3 | NA | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,CXCR4 | NA |
| PINK1 | 2.40e-01 | kinase | NA | NA | 1.0e-02 | CCND1,SLC2A1 | 43 (10) |
| baclofen | NA | chemical drug | NA | NA | 1.0e-02 | FOS,PER1 | 78 (17) |
| thymidine | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CCND1,CDKN1A | 87 (15) |
| androstenediol | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CDKN1A,FKBP5 | 78 (7) |
| AMPK | NA | complex | NA | NA | 1.0e-02 | CDKN1A,CXCL12,CYBB,NCF1,SLC2A1 | 83 (21) |
| TGFBR1 | -4.90e-01 | kinase | NA | NA | 1.0e-02 | AHR,C1QB,CCND1,CDKN1A,SFTPB | 110 (23) |
| Il3 | NA | cytokine | NA | NA | 1.0e-02 | CDKN1A,CSF3R,FOS,LCN2 | 81 (20) |
| 8-bromoguanosine 3’,5’-cyclic monophosphate | NA | chemical reagent | NA | NA | 1.0e-02 | CDKN1A,FOS,TGFB3 | 77 (19) |
| SKP2 | 3.70e-01 | other | NA | NA | 1.0e-02 | CCND1,CDKN1A,SLC2A1 | 98 (20) |
| GJA1 | -7.00e-02 | transporter | NA | NA | 1.0e-02 | CCND1,CDKN1A,TNFRSF11B | 104 (25) |
| FGFR3 | 2.20e-01 | kinase | NA | NA | 1.0e-02 | CCND1,CDKN1A,FOS | 78 (22) |
| GNB1 | 7.00e-02 | enzyme | NA | NA | 1.0e-02 | AHR,CDKN1A,IL1R2 | NA |
| MAP2K6 | -1.30e-01 | kinase | NA | NA | 1.0e-02 | CCND1,CDKN1A,CRYAB,MYH6 | 79 (21) |
| Hif1 | NA | complex | NA | NA | 1.0e-02 | CDKN1A,CXCR4,HIF3A,SLC2A1 | 43 (7) |
| BRD4 | NA | kinase | NA | NA | 1.0e-02 | AURKB,CCND1,CDKN1A,CXCR4,FOS,ID2 | 107 (20) |
| RELB | -1.50e-01 | transcription regulator | NA | NA | 1.0e-02 | CCND1,CDKN1A,CXCL12,NFKBIA | 68 (17) |
| cerivastatin | NA | chemical drug | NA | NA | 1.0e-02 | CDKN1A,DBI,ENPP3,NFYA | NA |
| interferon beta-1a | NA | biologic drug | NA | NA | 1.0e-02 | CCR5,CXCR4,GBP5,LAMP3,NFKBIA | NA |
| CLEC10A | 1.10e-01 | other | NA | NA | 1.0e-02 | ENDOU,MAP3K6,ZBTB16 | NA |
| TET1 | -2.80e-01 | enzyme | NA | NA | 1.0e-02 | FOS,MYH6,SLC40A1 | NA |
| ethionine | NA | chemical toxicant | NA | NA | 1.0e-02 | LCN2,LGALS3,SLC34A2 | NA |
| trypsin | NA | group | NA | NA | 1.0e-02 | CDKN1A,FOS | 61 (19) |
| KDM4D | 2.00e-01 | enzyme | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| CTNNBIP1 | 2.30e-01 | other | NA | NA | 1.0e-02 | CCND1,CDKN1A | 92 (18) |
| BCAR1 | 5.00e-02 | enzyme | NA | NA | 1.0e-02 | CCND1,CDKN1A | 90 (26) |
| B4GALNT1 | -1.30e-01 | enzyme | NA | NA | 1.0e-02 | C1QB,FOS | NA |
| OXTR | -2.90e-01 | G-protein coupled receptor | NA | NA | 1.0e-02 | FOS,PNPLA2 | NA |
| KRIT1 | -4.00e-02 | other | NA | NA | 1.0e-02 | CXCR4,NOTCH4 | NA |
| LETMD1 | 2.20e-01 | other | NA | NA | 1.0e-02 | CDKN1A,CYBB | 37 (7) |
| HSPA1A/HSPA1B | -4.00e-01 | enzyme | NA | NA | 1.0e-02 | CDKN1A,FOS | 77 (24) |
| sapanisertib | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CCR5 | 26 (3) |
| 1-chloro-2-(2,2,2-trichloro-1-(4-chlorophenyl)ethyl)benzene | NA | chemical toxicant | NA | NA | 1.0e-02 | AHR,CDKN1A | NA |
| astressin 2B | NA | biologic drug | NA | NA | 1.0e-02 | FOS,SLC2A1 | 58 (11) |
| oleanolic acid | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | AHR,CCND1,CDKN1A | 92 (16) |
| RCE1 | 4.00e-02 | peptidase | NA | NA | 1.0e-02 | CRYAB,CXCL12,PRRX2 | NA |
| CCR5 | -5.90e-01 | G-protein coupled receptor | NA | NA | 1.0e-02 | CCR5,CXCL12,FOS | 85 (18) |
| plerixafor | NA | chemical drug | NA | NA | 1.0e-02 | CXCL12,CXCR4,KITLG | 79 (22) |
| TBX5 | -3.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CXCR4,GJA5,MYH6,POSTN | 24 (5) |
| POR | 9.00e-02 | enzyme | NA | NA | 1.0e-02 | AHR,EHHADH,INSIG1,MAP3K6,Mt1,Slco1a4 | NA |
| MSX2 | -1.30e-01 | transcription regulator | NA | NA | 1.0e-02 | CCND1,TGFB3,WNT7A | 47 (9) |
| carbamylcholine | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CDKN1A,FOS | 72 (23) |
| ibuprofen | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CYBB,SLC2A1 | 70 (15) |
| 1,2-dimethylhydrazine | NA | chemical toxicant | NA | NA | 1.0e-02 | CCND1,RNF152,TNFRSF11B | NA |
| retinoid | NA | chemical drug | NA | NA | 1.0e-02 | CDKN1A,RPE65,TLR2 | NA |
| phenacetin | NA | chemical drug | NA | NA | 1.0e-02 | LCN2,LGALS3,SLC34A2 | NA |
| MACROH2A1 | NA | other | NA | NA | 1.0e-02 | CDKN1A,HIF3A,NOTCH4,SLC2A1 | NA |
| MBD3 | 2.00e-01 | other | NA | NA | 1.0e-02 | CCND1,Mt1,MYH6,WNT7A | NA |
| PTHLH | NA | other | NA | NA | 1.0e-02 | CCND1,CDKN1A,FOS,TNFRSF11B | 103 (23) |
| 16,16-dimethylprostaglandin E2 | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CXCR4,FOS | 64 (12) |
| Rac | NA | group | NA | NA | 1.0e-02 | CCND1,FOS | 68 (17) |
| dihydroartemisinin | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CDKN1A | 76 (22) |
| doramapimod | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,TLR2 | 63 (17) |
| Ptprd | NA | phosphatase | NA | NA | 1.0e-02 | CDKN1A,GADD45G | 46 (7) |
| SMOC2 | 1.60e-01 | other | NA | NA | 1.0e-02 | AURKB,MCM10 | NA |
| LINC-ROR | NA | other | NA | NA | 1.0e-02 | CDKN1A,TESC | NA |
| VLDLR | 2.00e-01 | transporter | NA | NA | 1.0e-02 | FOS,SLC2A1 | 43 (7) |
| ethyl 2-{[(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate | NA | chemical reagent | NA | NA | 1.0e-02 | CDKN1A,POU3F2 | NA |
| anti-benzo(a)pyrene-diol-epoxide | NA | chemical toxicant | NA | NA | 1.0e-02 | CCND1,CDKN1A | 90 (23) |
| Laminin (complex) | NA | complex | NA | NA | 1.0e-02 | CCND1,CDH11,ID2 | 73 (16) |
| SLC27A2 | -2.00e-02 | transporter | NA | NA | 1.0e-02 | EHHADH,PEX11A,PLIN5 | NA |
| pituitary adenylate cyclase-activating polypeptide | NA | biologic drug | NA | NA | 1.0e-02 | ACER2,CCND1,CRYAB | NA |
| ABL1 | 1.80e-01 | kinase | NA | NA | 1.0e-02 | CCND1,CDKN1A,TGFB3 | 88 (19) |
| SRSF2 | 7.00e-02 | transcription regulator | NA | NA | 1.0e-02 | AURKB,CCND1,MLXIPL | 64 (7) |
| thymoquinone | NA | chemical drug | NA | NA | 1.0e-02 | CDKN1A,CXCR4,TLR4 | 67 (12) |
| SUMO2 | 1.60e-01 | enzyme | NA | NA | 1.0e-02 | ENPP3,LAMP3,PLA2G3 | NA |
| IRS2 | -5.00e-02 | enzyme | NA | NA | 1.0e-02 | CCND1,FOS,SLC2A1 | 107 (23) |
| SKIL | -1.50e-01 | transcription regulator | NA | NA | 1.0e-02 | CDH11,CDKN1A,CXCL12 | NA |
| CSF1R | -3.00e-02 | kinase | NA | NA | 1.0e-02 | CCND1,CDKN1A,FOS | 80 (22) |
| ELANE | NA | peptidase | NA | NA | 1.0e-02 | CSF3R,FOS,TLR4 | 60 (11) |
| azoxymethane | NA | chemical toxicant | NA | NA | 1.0e-02 | CCND1,CDKN1A,FZD10,PTP4A3 | 53 (12) |
| sorbitol | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CDKN1A,SGK1 | 81 (21) |
| IFNL2 | NA | other | NA | NA | 1.0e-02 | CCR5,CXCR4 | 46 (7) |
| IGFBP7 | 1.00e-01 | transporter | NA | NA | 1.0e-02 | CCND1,CDKN1A | 82 (21) |
| Betacatenin/TCF | NA | complex | NA | NA | 1.0e-02 | CCND1,TNFRSF11B | NA |
| mir-455 | NA | microRNA | NA | NA | 1.0e-02 | CCND1,RUNX1T1 | NA |
| GHRHR | 2.90e-01 | G-protein coupled receptor | NA | NA | 1.0e-02 | CCND1,FOS | 92 (24) |
| PER2 | -1.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CCND1,PER1 | 42 (7) |
| KLK1 | 0.00e+00 | peptidase | NA | NA | 1.0e-02 | CYBB,NCF1 | NA |
| CAMKK2 | -4.00e-02 | kinase | NA | NA | 1.0e-02 | CCND1,CDKN1A | 109 (24) |
| zinc protoporphyrin IX | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CCND1,CDKN1A | 78 (18) |
| gamma-tocotrienol | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,NFKBIA | 65 (14) |
| zalcitabine | NA | chemical drug | NA | NA | 1.0e-02 | CXCL12,SLC2A1 | 37 (7) |
| A2M | 1.20e-01 | transporter | NA | NA | 1.0e-02 | CCND1,SLC2A1,SLC40A1 | 65 (12) |
| HOXA5 | -2.00e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,NFKBIA,TGFB3 | NA |
| EPCAM | 3.00e-01 | other | NA | NA | 1.0e-02 | CCND1,CDKN1A,FOS | 77 (21) |
| CDK8 | -7.00e-02 | kinase | NA | NA | 1.0e-02 | CXCR4,NR0B1,Podxl | NA |
| ESRRB | 0.00e+00 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,NR0B1,STARD8 | NA |
| MRGPRX3 | -3.20e-01 | G-protein coupled receptor | NA | NA | 1.0e-02 | CSF3R,CXCR4,DHRS9 | NA |
| baicalein | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CYBB,FOS | 88 (21) |
| apigenin | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | CCND1,CDKN1A,FOS,MYH6 | 75 (22) |
| PRDM5 | 9.00e-02 | transcription regulator | NA | NA | 1.0e-02 | ID2,ISLR2,POU2F3,SNRNP48 | NA |
| lipoxin A4 | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CCND1,CCR5,CDKN1A | 99 (21) |
| VitaminD3-VDR-RXR | NA | complex | NA | NA | 1.0e-02 | CDKN1A,COL13A1,CST6 | NA |
| OVOL2 | -1.90e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,SLC2A1,STARD8 | NA |
| CYP1A2 | 3.00e-02 | enzyme | NA | NA | 1.0e-02 | CCND1,INSC,Mt1 | NA |
| N-acetylsphingosine | NA | chemical reagent | NA | NA | 1.0e-02 | CDKN1A,CRYAB,FOS | 89 (23) |
| ADAM17 | -4.10e-01 | peptidase | NA | NA | 1.0e-02 | CCND1,GADD45G,PGF,TNFRSF11B,WNT7A | 112 (19) |
| BLU 9931 | NA | chemical drug | NA | NA | 1.0e-02 | CCND1 | NA |
| CSDE1 HNRNPD PABP PAIP1 SYNCRIP | NA | complex | NA | NA | 1.0e-02 | FOS | NA |
| beta-escin | NA | chemical drug | NA | NA | 1.0e-02 | CDKN1A | NA |
| azide | NA | chemical reagent | NA | NA | 1.0e-02 | SLC2A1 | NA |
| Keratin 16 | NA | group | NA | NA | 1.0e-02 | CCND1 | NA |
| LM-1685 | NA | chemical reagent | NA | NA | 1.0e-02 | CCND1 | NA |
| bixin | NA | chemical drug | NA | NA | 1.0e-02 | PTCH1 | NA |
| mitotam | NA | chemical drug | NA | NA | 1.0e-02 | CDKN1A | NA |
| 2-methylthiazoline | NA | chemical reagent | NA | NA | 1.0e-02 | FOS | NA |
| eicosa-11Z, 14Z-dienoic acid | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | PNPLA2 | NA |
| peptide YY 3-36 | NA | biologic drug | NA | NA | 1.0e-02 | FOS | NA |
| hydroxamic acid | NA | chemical - other | NA | NA | 1.0e-02 | CXCR4 | NA |
| growth factor receptor | NA | group | NA | NA | 1.0e-02 | FOS | NA |
| SHIP | NA | group | NA | NA | 1.0e-02 | Klra2 | NA |
| MK 212 | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| tandospirone | NA | chemical drug | NA | NA | 1.0e-02 | PER1 | NA |
| ginsenoside derivative | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | FOS | NA |
| GSK 189254 | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| (-)-OSU 6162 | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| HCG11 | NA | other | NA | NA | 1.0e-02 | CDKN1A | NA |
| LINC00475 | NA | other | NA | NA | 1.0e-02 | CDKN1A | NA |
| NCK | NA | group | NA | NA | 1.0e-02 | CCND1 | 34 (6) |
| pridopidine | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| ABCA3 | -1.60e-01 | transporter | NA | NA | 1.0e-02 | SFTPB | NA |
| SRF-ELK1 | NA | complex | NA | NA | 1.0e-02 | FOS | NA |
| KCNJ12 | 8.00e-02 | ion channel | NA | NA | 1.0e-02 | CCND1 | NA |
| ARMC10 | 2.00e-02 | other | NA | NA | 1.0e-02 | CDKN1A | NA |
| CALCOCO1 | 7.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CCND1 | NA |
| URGCP | 6.00e-02 | other | NA | NA | 1.0e-02 | CCND1 | NA |
| ADGRF4 | -2.00e-02 | G-protein coupled receptor | NA | NA | 1.0e-02 | CA6 | NA |
| FKBPL | 6.00e-02 | other | NA | NA | 1.0e-02 | CDKN1A | NA |
| ZBTB7C | -2.10e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A | NA |
| MACROD1 | 2.70e-01 | enzyme | NA | NA | 1.0e-02 | NFKBIA | NA |
| CXXC1 | -2.10e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A | NA |
| PART1 | NA | other | NA | NA | 1.0e-02 | ZBTB16 | NA |
| CCDC62 | -2.20e-01 | transcription regulator | NA | NA | 1.0e-02 | CCND1 | NA |
| STAT1/3 dimer | NA | complex | NA | NA | 1.0e-02 | FOS | NA |
| ZBTB8A | 3.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A | NA |
| PLEK2 | 9.00e-02 | other | NA | NA | 1.0e-02 | LCN2 | NA |
| HASPIN | NA | kinase | NA | NA | 1.0e-02 | CDKN1A | NA |
| boldine | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | NCF1 | NA |
| ZG16B | NA | other | NA | NA | 1.0e-02 | CXCR4 | NA |
| FGF14 | 1.60e-01 | growth factor | NA | NA | 1.0e-02 | FOS | NA |
| PLAC1 | NA | other | NA | NA | 1.0e-02 | CCND1 | NA |
| PCIF1 | 2.40e-01 | enzyme | NA | NA | 1.0e-02 | FOS | NA |
| Oxi-4503 | NA | chemical drug | NA | NA | 1.0e-02 | CXCL12 | NA |
| cis-vaccenic acid | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | PNPLA2 | NA |
| 7-bromoindirubin-3’-oxime | NA | chemical - kinase inhibitor | NA | NA | 1.0e-02 | CDKN1A | NA |
| vasopressins | NA | biologic drug | NA | NA | 1.0e-02 | FOS | NA |
| inolitazone | NA | chemical drug | NA | NA | 1.0e-02 | CDKN1A | NA |
| Integrin alpha 5 beta 1 | NA | complex | NA | NA | 1.0e-02 | CCND1 | NA |
| mediator | NA | complex | NA | NA | 1.0e-02 | FOS | NA |
| Mapk kinase | NA | group | NA | NA | 1.0e-02 | CCND1 | NA |
| ARHGEF17 | -6.00e-02 | other | NA | NA | 1.0e-02 | FOS | 34 (6) |
| pidilizumab | NA | biologic drug | NA | NA | 1.0e-02 | CXCR4 | NA |
| pirinixil | NA | chemical reagent | NA | NA | 1.0e-02 | EHHADH | NA |
| Tenascin | NA | group | NA | NA | 1.0e-02 | CCND1 | NA |
| CABLES1 | -7.00e-02 | other | NA | NA | 1.0e-02 | CDKN1A | NA |
| KIFAP3 | 0.00e+00 | other | NA | NA | 1.0e-02 | FOS | 34 (6) |
| CDT1 | 2.80e-01 | other | NA | NA | 1.0e-02 | CDKN1A | NA |
| PPY | NA | other | NA | NA | 1.0e-02 | FOS | NA |
| ACVR2B | -2.50e-01 | kinase | NA | NA | 1.0e-02 | CDKN1A | NA |
| GPHA2 | 0.00e+00 | other | NA | NA | 1.0e-02 | FOS | NA |
| recombinant interferon alpha | NA | biologic drug | NA | NA | 1.0e-02 | RNF213 | NA |
| ADCY2 | 8.00e-02 | enzyme | NA | NA | 1.0e-02 | CCND1 | NA |
| miR-523-3p (miRNAs w/seed AACGCGC) | NA | mature microRNA | NA | NA | 1.0e-02 | CDKN1A | NA |
| mir-1906 | NA | microRNA | NA | NA | 1.0e-02 | TLR4 | NA |
| miR-212-5p (miRNAs w/seed CCUUGGC) | NA | mature microRNA | NA | NA | 1.0e-02 | PTCH1 | NA |
| miR-1246 (miRNAs w/seed AUGGAUU) | NA | mature microRNA | NA | NA | 1.0e-02 | TERF2IP | NA |
| miR-105-5p (and other miRNAs w/seed CAAAUGC) | NA | mature microRNA | NA | NA | 1.0e-02 | TLR2 | NA |
| TIMELESS | -8.00e-02 | other | NA | NA | 1.0e-02 | PER1 | NA |
| NPVF | 3.40e-01 | other | NA | NA | 1.0e-02 | FOS | NA |
| ZBTB5 | -1.60e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A | NA |
| DHX8 | -5.00e-02 | enzyme | NA | NA | 1.0e-02 | CDKN1A | NA |
| EPSTI1 | -3.10e-01 | other | NA | NA | 1.0e-02 | NFKBIA | NA |
| ZNF613 | -2.90e-01 | transcription regulator | NA | NA | 1.0e-02 | ID2 | NA |
| TOB2 | 1.10e-01 | other | NA | NA | 1.0e-02 | CCND1 | NA |
| SLC1A2 | -1.20e-01 | transporter | NA | NA | 1.0e-02 | FOS | NA |
| GTPBP4 | 1.00e-01 | enzyme | NA | NA | 1.0e-02 | CCND1 | NA |
| GPHB5 | NA | other | NA | NA | 1.0e-02 | FOS | NA |
| SCN7A | -7.00e-02 | ion channel | NA | NA | 1.0e-02 | FOS | NA |
| DNASE1L3 | -5.00e-02 | enzyme | NA | NA | 1.0e-02 | CDKN1A | NA |
| NXF3 | 4.00e-02 | transporter | NA | NA | 1.0e-02 | TGFB3 | NA |
| CCNI | -5.00e-02 | other | NA | NA | 1.0e-02 | CDKN1A | NA |
| ANKS1A | 1.60e-01 | other | NA | NA | 1.0e-02 | FOS | NA |
| FXYD1 | 4.00e-01 | ion channel | NA | NA | 1.0e-02 | CDKN1A | NA |
| PTPRU | -1.00e-02 | phosphatase | NA | NA | 1.0e-02 | CCND1 | NA |
| PMS2 | NA | enzyme | NA | NA | 1.0e-02 | CCND1 | NA |
| XPO7 | -1.40e-01 | transporter | NA | NA | 1.0e-02 | CDKN1A | NA |
| EPGN | 2.40e-01 | growth factor | NA | NA | 1.0e-02 | FOS | NA |
| TAX1BP3 | NA | transcription regulator | NA | NA | 1.0e-02 | FOS | NA |
| ING3 | -1.00e-01 | other | NA | NA | 1.0e-02 | CDKN1A | NA |
| JAM2 | -1.00e-01 | other | NA | NA | 1.0e-02 | CXCL12 | NA |
| CTSH | 4.00e-02 | peptidase | NA | NA | 1.0e-02 | SFTPB | NA |
| JADE1 | -6.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A | NA |
| RAB5B | 6.00e-02 | enzyme | NA | NA | 1.0e-02 | FOS | NA |
| CDK20 | 1.10e-01 | kinase | NA | NA | 1.0e-02 | CCND1 | NA |
| CD164 | -2.00e-02 | other | NA | NA | 1.0e-02 | CXCR4 | NA |
| cytarabine/filgrastim/fludarabine phosphate | NA | biologic drug | NA | NA | 1.0e-02 | FOS | NA |
| PTOV1 | 9.00e-02 | other | NA | NA | 1.0e-02 | CCND1 | NA |
| UBE2E1 | 1.70e-01 | enzyme | NA | NA | 1.0e-02 | CDKN1A | NA |
| tetramethylpyrazine | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | CXCR4 | NA |
| CUL9 | -1.00e-01 | other | NA | NA | 1.0e-02 | CDKN1A | NA |
| SCML2 | 1.00e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A | NA |
| TDP-665759 | NA | chemical reagent | NA | NA | 1.0e-02 | CDKN1A | NA |
| RPLP0 | 3.20e-01 | other | NA | NA | 1.0e-02 | CCND1 | NA |
| E. coli 0111:B4 peptidoglycan | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | DBI | NA |
| belzutifan | NA | chemical drug | NA | NA | 1.0e-02 | CXCL12 | NA |
| dexamethasone/tobramycin | NA | chemical drug | NA | NA | 1.0e-02 | TLR2 | NA |
| NBI 27914 | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| 8-carboxamidocyclazocine | NA | chemical reagent | NA | NA | 1.0e-02 | CCR5 | NA |
| guanfacine | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| BW A868C | NA | chemical reagent | NA | NA | 1.0e-02 | ENPP3 | NA |
| triparanol | NA | chemical drug | NA | NA | 1.0e-02 | PTCH1 | NA |
| ondansetron | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| flurothyl | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| diisopropanolnitrosamine | NA | chemical toxicant | NA | NA | 1.0e-02 | CDKN1A | NA |
| L 733060 | NA | chemical reagent | NA | NA | 1.0e-02 | FOS | NA |
| sulfaphenazole | NA | chemical drug | NA | NA | 1.0e-02 | CCND1 | NA |
| selfotel | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| (R)-5-(2-azetidnylmethoxy)-2-chloropyridine | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| Ro 20-1724 | NA | chemical reagent | NA | NA | 1.0e-02 | CCND1 | NA |
| galnon | NA | chemical reagent | NA | NA | 1.0e-02 | FOS | NA |
| aminooxypentane-rantes | NA | chemical reagent | NA | NA | 1.0e-02 | CCR5 | NA |
| NSC 126405 | NA | chemical reagent | NA | NA | 1.0e-02 | CDKN1A | NA |
| triazolam | NA | chemical drug | NA | NA | 1.0e-02 | PER1 | NA |
| dihydrokainic acid | NA | chemical reagent | NA | NA | 1.0e-02 | FOS | NA |
| ONO-8711 | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| anti-miR-302d | NA | chemical reagent | NA | NA | 1.0e-02 | CCND1 | NA |
| anti-miR-302c inhibitor | NA | chemical reagent | NA | NA | 1.0e-02 | CCND1 | NA |
| beta-penta-O-galloyl-glucose | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | CCND1 | NA |
| CTOP | NA | chemical reagent | NA | NA | 1.0e-02 | FOS | NA |
| Ac-DEVD-CHO | NA | chemical reagent | NA | NA | 1.0e-02 | FOS | NA |
| ibutamoren | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| limonoate D-ring-lactone | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | TLR4 | NA |
| LY 354740 | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| droxidopa | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| S(-)-carbidopa | NA | chemical drug | NA | NA | 1.0e-02 | FOS | NA |
| sarcosine | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | FOS | NA |
| agar | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | RBM3 | NA |
| gestodene | NA | chemical drug | NA | NA | 1.0e-02 | TGFB3 | NA |
| NSC 228155 | NA | chemical reagent | NA | NA | 1.0e-02 | CCND1 | NA |
| NACHR | NA | group | NA | NA | 1.0e-02 | CCND1 | NA |
| AMBRA1 | 0.00e+00 | other | NA | NA | 1.0e-02 | CCND1,CDKN1A,TGFB3 | 56 (12) |
| everolimus | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CDKN1A,SLC2A1 | 92 (19) |
| cyclopamine | NA | chemical reagent | NA | NA | 1.0e-02 | CCND1,CDKN1A,PTCH1 | 63 (9) |
| prostaglandin A2 | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | CCND1,CDKN1A | 104 (26) |
| cyclic GMP | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CDKN1A,FOS | 99 (21) |
| glycerol | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | PTCH1,TLR4 | NA |
| TMPRSS6 | -4.00e-02 | peptidase | NA | NA | 1.0e-02 | CDKN1A,SLC40A1 | NA |
| COL1A1 | -1.40e-01 | other | NA | NA | 1.0e-02 | CDKN1A,CXCR4 | 32 (7) |
| mir-3622 | NA | microRNA | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| MAPK10 | 0.00e+00 | kinase | NA | NA | 1.0e-02 | FOS,WNT7A | NA |
| HNRNPD | 1.80e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,FOS | 61 (12) |
| IQGAP1 | -1.50e-01 | other | NA | NA | 1.0e-02 | CCND1,CXCR4 | 73 (20) |
| Gm12602 | NA | other | NA | NA | 1.0e-02 | CRYAB,DHRS9 | NA |
| 2-acetylaminofluorene | NA | chemical toxicant | NA | NA | 1.0e-02 | CCND1,CDKN1A | 47 (12) |
| glyburide | NA | chemical drug | NA | NA | 1.0e-02 | FOS,SLC2A1 | NA |
| N1,N11-diethylnorspermine | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CDKN1A | 87 (26) |
| spermidine | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CDKN1A,FOS | 76 (24) |
| caffeic acid | NA | chemical drug | NA | NA | 1.0e-02 | AHR,TLR4 | 38 (7) |
| mannose | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | FOS,GPD1 | NA |
| FGF19 | NA | growth factor | NA | NA | 1.0e-02 | CCND1,FOS,LCN2,SGK1 | 90 (23) |
| gemcitabine | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CDKN1A,CXCL12,CXCR4 | 81 (22) |
| Hsp27 | NA | group | NA | NA | 1.0e-02 | CCND1,CDKN1A,FOS | 89 (23) |
| ZMPSTE24 | -1.40e-01 | peptidase | NA | NA | 1.0e-02 | CDKN1A,FMO2,GADD45G | NA |
| TOB1 | -2.20e-01 | transcription regulator | NA | NA | 1.0e-02 | BANP,CCND1,CDKN1A | 93 (24) |
| ADRA1B | 2.30e-01 | G-protein coupled receptor | NA | NA | 1.0e-02 | CCND1,CDKN1A,FOS | 87 (21) |
| tetrodotoxin | NA | chemical drug | NA | NA | 1.0e-02 | HCRTR2,INSIG1,KCNA4,Mt1,RNF152 | NA |
| gefitinib | NA | chemical drug | NA | NA | 1.0e-02 | AURKB,CCND1,FMO2,IL1R2,PCDH12,TLR2 | NA |
| IL23 | NA | complex | NA | NA | 1.0e-02 | AHR,TLR2,TLR4 | NA |
| baicalin | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | TLR2,TLR4,TNFRSF11B | NA |
| ITGA5 | -1.40e-01 | transmembrane receptor | NA | NA | 1.0e-02 | CCND1,CDKN1A,FOS | NA |
| TFAP4 | 1.00e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,FOS,RPE65 | NA |
| TWIST2 | 3.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CCND1,CDKN1A,POSTN | NA |
| SP4 | -4.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CCND1,CDKN1A,KITLG | NA |
| TXN | 4.50e-01 | enzyme | NA | NA | 1.0e-02 | CDKN1A,FOS,NFKBIA | NA |
| 14,15-epoxyeicosatrienoic acid | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | TNFRSF11A,TNFRSF11B | NA |
| doxifluridine | NA | chemical drug | NA | NA | 1.0e-02 | CDKN1A,RPL10A | NA |
| UCN2 | 1.00e-01 | other | NA | NA | 1.0e-02 | FOS,TLR4 | NA |
| Hmgb1 | 1.00e-01 | transcription regulator | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| PPP1R1B | 5.70e-01 | phosphatase | NA | NA | 1.0e-02 | CCND1,FOS | NA |
| NDUFA13 | 4.20e-01 | enzyme | NA | NA | 1.0e-02 | CCND1,PRRX2 | NA |
| HBP1 | -1.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| STK3 | -1.00e-02 | kinase | NA | NA | 1.0e-02 | CCND1,SFTPB | NA |
| GAL | 2.10e-01 | other | NA | NA | 1.0e-02 | CDKN1A,FOS | NA |
| CNOT3 | -7.00e-02 | other | NA | NA | 1.0e-02 | CDKN1A,TNFRSF11A | NA |
| 7-nitroindazole | NA | chemical reagent | NA | NA | 1.0e-02 | FOS,NFKBIA | NA |
| decursin | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| hexarelin | NA | chemical toxicant | NA | NA | 1.0e-02 | INSIG1,PNPLA2 | NA |
| canrenoate potassium | NA | chemical drug | NA | NA | 1.0e-02 | CDKN1A,LGALS3 | NA |
| manganese | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CDKN1A,SLC40A1 | NA |
| RORC | NA | ligand-dependent nuclear receptor | NA | NA | 1.0e-02 | ELOVL7,LCN2,Mt1,Nat8f5,Slco1a4,ZBTB16 | NA |
| ADAM10 | -3.10e-01 | peptidase | NA | NA | 1.0e-02 | CCND1,CRYAB,CXCL12,FOS,GADD45G | NA |
| MYOCD | -3.20e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,FOS,GJA5,MYH6 | NA |
| PRKN | NA | enzyme | NA | NA | 1.0e-02 | CCND1,CDKN1A,CXCL12,TNFRSF11B | NA |
| WWTR1 | -2.50e-01 | transcription regulator | NA | NA | 1.0e-02 | ADGRG5,CCND1,CDKN1A,ID2,PLIN4 | NA |
| NOS3 | -1.10e-01 | enzyme | NA | NA | 1.0e-02 | CXCL12,SLC2A1,TLR4 | NA |
| SOX10 | -1.90e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,ERBB3,FOS | NA |
| PNPT1 | -1.20e-01 | enzyme | NA | NA | 1.0e-02 | CDKN1A,Irgm1,RNF213 | NA |
| FASLG | -3.00e-02 | cytokine | NA | NA | 1.0e-02 | FOS,TGFB3,TNFRSF11B | NA |
| PF543 | NA | chemical drug | NA | NA | 1.0e-02 | ADAMTS4,CCR5,TNFRSF11B | NA |
| D-galactosamine | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | FOS,NFKBIA,TLR4 | NA |
| nocodazole | NA | chemical reagent | NA | NA | 1.0e-02 | CCND1,CDKN1A,FOS,UHRF1 | NA |
| AURK | NA | group | NA | NA | 1.0e-02 | ACER2,AEN,CDKN1A | NA |
| H2AB3 (includes others) | NA | other | NA | NA | 1.0e-02 | CDKN1A,DHRS9,FOS | NA |
| ANLN | -1.00e-02 | other | NA | NA | 1.0e-02 | ACER2,AEN,CDKN1A | NA |
| IL11RA | 1.60e-01 | transmembrane receptor | NA | NA | 1.0e-02 | FOS,POSTN,RPE65 | NA |
| MAX | 1.00e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,ID2,MYH6,SLC2A1 | NA |
| N(6)-(3-iodobenzyl)-5’-N-methylcarboxamidoadenosine | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,FOS | NA |
| alpha-amanitin | NA | chemical toxicant | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| RNA fragment | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | NFKBIA,SLC40A1 | NA |
| Pdgf Ab | NA | complex | NA | NA | 1.0e-02 | CCND1,FOS | NA |
| AGO1 | -3.00e-01 | translation regulator | NA | NA | 1.0e-02 | CDKN1A,CXCR4 | NA |
| ERFE | 0.00e+00 | other | NA | NA | 1.0e-02 | ID2,TNFRSF11B | NA |
| hemoglobin | NA | complex | NA | NA | 1.0e-02 | CDKN1A,SLC40A1 | NA |
| ghrelin | NA | biologic drug | NA | NA | 1.0e-02 | FOS,TNFRSF11B | NA |
| Cyp2c23 | 1.00e-02 | enzyme | NA | NA | 1.0e-02 | ASPA,MERTK | NA |
| PPP3CB | 2.00e-01 | phosphatase | NA | NA | 1.0e-02 | CDKN1A,CYBB | NA |
| RAB2A | 2.60e-01 | enzyme | NA | NA | 1.0e-02 | PLIN4,PLIN5 | NA |
| PDGFRA | -1.00e-01 | kinase | NA | NA | 1.0e-02 | CDKN1A,FOS | NA |
| AKR1B1 | 1.20e-01 | enzyme | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| erastin | NA | chemical drug | NA | NA | 1.0e-02 | CDKN1A,LCN2 | NA |
| XPO1 | -3.00e-01 | transporter | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| acyclic retinoid | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| pregnenolone carbonitrile | NA | chemical drug | NA | NA | 1.0e-02 | INSIG1,Slco1a4,SLCO1C1 | NA |
| MAP2K5 | 2.20e-01 | kinase | NA | NA | 1.0e-02 | CCND1,FOS,INSIG1 | NA |
| CTBP1 | 3.00e-02 | enzyme | NA | NA | 1.0e-02 | CDKN1A,FKBP5,FOS | NA |
| IPMK | -4.00e-02 | kinase | NA | NA | 1.0e-02 | AHR,FOS,PER1 | NA |
| BCOR | -5.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,PTCH1,TLR4 | NA |
| SPHK1 | -1.10e-01 | kinase | NA | NA | 1.0e-02 | CCND1,CDKN1A,SLC2A1 | NA |
| advanced glycation end-products | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CDKN1A,CXCL12,TLR4 | NA |
| N-formyl-Met-Leu-Phe | NA | chemical reagent | NA | NA | 1.0e-02 | CCR5,CYBB,NFKBIA | NA |
| N-(1-carbamoyl-2-phenyl-ethyl) butyramide | NA | chemical reagent | NA | NA | 1.0e-02 | TLR2,TLR4 | NA |
| oridonin | NA | chemical drug | NA | NA | 1.0e-02 | CDKN1A,CSF3R | NA |
| GRK2 | 6.00e-02 | kinase | NA | NA | 1.0e-02 | FOS,TNFRSF11B | NA |
| S100B | 2.30e-01 | other | NA | NA | 1.0e-02 | CDKN1A,FOS | NA |
| SLC29A1 | 0.00e+00 | transporter | NA | NA | 1.0e-02 | CDKN1A,RPL10A | NA |
| PCBP2 | 1.00e-02 | other | NA | NA | 1.0e-02 | CDKN1A,CSF3R | NA |
| NEDD4 | NA | enzyme | NA | NA | 1.0e-02 | CDKN1A,ERBB3 | NA |
| tomatidine | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | FOS,TNFRSF11A | NA |
| hydroquinone | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | FOS,SLC2A1 | NA |
| diethylmaleate | NA | chemical toxicant | NA | NA | 1.0e-02 | CDKN1A,NFKBIA | NA |
| Histone h4 | NA | group | NA | NA | 1.0e-02 | CCND1,CDKN1A,FOS,Mt1,RPL10A | NA |
| ROCK | NA | group | NA | NA | 1.0e-02 | CCND1,CDKN1A,FOS | NA |
| ANXA1 | 4.00e-02 | enzyme | NA | NA | 1.0e-02 | CXCR4,LGALS3,TLR4 | NA |
| nitroprusside | NA | chemical drug | NA | NA | 1.0e-02 | FOS,TLR2,TNFRSF11B | NA |
| CEBPE | -1.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CSF3R,LCN2,NCF1 | NA |
| EIF2S1 | 5.00e-02 | translation regulator | NA | NA | 1.0e-02 | CA6,CCND1,PLIN4 | NA |
| NR2F1 | -2.20e-01 | ligand-dependent nuclear receptor | NA | NA | 1.0e-02 | ID2,LFNG,NR0B1 | NA |
| salicylic acid | NA | chemical drug | NA | NA | 1.0e-02 | FKBP5,KITLG,TLR4 | NA |
| kawain | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | TLR2,TLR4 | NA |
| PPP1R13L | -3.50e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,SLC2A1 | NA |
| KCNJ10 | -1.80e-01 | ion channel | NA | NA | 1.0e-02 | GBP5,LGALS3 | NA |
| LY6E | 1.60e-01 | other | NA | NA | 1.0e-02 | IRAK2,NFKBIA | NA |
| HRG | NA | other | NA | NA | 1.0e-02 | C1QB,CXCR4 | NA |
| ACTN4 | -1.50e-01 | transcription regulator | NA | NA | 1.0e-02 | CCND1,FOS | NA |
| HNRNPAB | NA | enzyme | NA | NA | 1.0e-02 | AURKB,UHRF1 | NA |
| prazosin | NA | chemical drug | NA | NA | 1.0e-02 | FOS,PER1 | NA |
| sulfasalazine | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,NFKBIA | NA |
| NCD-38 | NA | chemical reagent | NA | NA | 1.0e-02 | TNFRSF11A,UHRF1 | NA |
| (1S,2R)-NCL-1 | NA | chemical reagent | NA | NA | 1.0e-02 | TNFRSF11A,UHRF1 | NA |
| lycopene | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| KT5823 | NA | chemical - kinase inhibitor | NA | NA | 1.0e-02 | FOS,SLC2A1 | NA |
| finasteride | NA | chemical drug | NA | NA | 1.0e-02 | FOS,TGFB3 | NA |
| platelet activating factor | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CDKN1A,FOS,NFKBIA | NA |
| Stat3-Stat3 | NA | complex | NA | NA | 1.0e-02 | CCND1,CDKN1A,FOS | NA |
| VEGFB | 1.30e-01 | growth factor | NA | NA | 1.0e-02 | Casp12,EHHADH,MYH6 | NA |
| IGFBP2 | -3.00e-02 | other | NA | NA | 1.0e-02 | CCND1,POSTN,TGFB3 | NA |
| mir-24 | NA | microRNA | NA | NA | 1.0e-02 | AHR,CDKN1A,ID2 | NA |
| 3-methylcholanthrene | NA | chemical toxicant | NA | NA | 1.0e-02 | CCND1,FOS,Mt1 | NA |
| CLEC4G | 6.00e-02 | other | NA | NA | 2.0e-02 | NOTCH4,NRARP,TGFB3 | NA |
| NKX3-1 | -6.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CA12,FKBP5,FOS | NA |
| KAT2B | -4.60e-01 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A,PTCH1,SLC2A1 | NA |
| ABCA1 | -2.60e-01 | transporter | NA | NA | 2.0e-02 | INSIG1,SLC2A1,TLR4 | NA |
| luteolin | NA | chemical drug | NA | NA | 2.0e-02 | CCND1,FOS,TLR4 | NA |
| Srebp | NA | group | NA | NA | 2.0e-02 | CDKN1A,FOS | NA |
| GPR39 | 3.00e-02 | G-protein coupled receptor | NA | NA | 2.0e-02 | PGF,PNPLA2 | NA |
| FGD3 | -8.00e-02 | other | NA | NA | 2.0e-02 | NFKBIA,TLR4 | NA |
| STAP2 | -1.20e-01 | other | NA | NA | 2.0e-02 | CCND1,CXCR4 | NA |
| EDN3 | -3.30e-01 | other | NA | NA | 2.0e-02 | CCND1,FOS | NA |
| SP100 | NA | transcription regulator | NA | NA | 2.0e-02 | CDKN1A,FOS | NA |
| PER1 | 5.90e-01 | transcription regulator | NA | NA | 2.0e-02 | CCND1,PER1 | NA |
| RND3 | -2.80e-01 | enzyme | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| DLX3 | -1.10e-01 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A,PGF | NA |
| ST8SIA1 | -2.60e-01 | enzyme | NA | NA | 2.0e-02 | C1QB,CDKN1A | NA |
| PD 169316 | NA | chemical drug | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| tranylcypromine | NA | chemical drug | NA | NA | 2.0e-02 | CDKN1A,FOS | NA |
| PD 153035 | NA | chemical drug | NA | NA | 2.0e-02 | CCND1,FOS | NA |
| MDL 73811 | NA | chemical reagent | NA | NA | 2.0e-02 | CDKN1A,LGALS3 | NA |
| DMD | NA | other | NA | NA | 2.0e-02 | C1QB,CDKN1A,GJA5,GPD1,IP6K3,POSTN | NA |
| 1,1-diarylethylene-diammonium derivative | NA | chemical reagent | NA | NA | 2.0e-02 | AURKB,CDKN1A,HELZ2 | NA |
| CLUH | -6.00e-02 | translation regulator | NA | NA | 2.0e-02 | ENPP3,LCN2,TACO1 | NA |
| MAP2K4 | 6.00e-02 | kinase | NA | NA | 2.0e-02 | CCND1,CDKN1A,FOS | NA |
| CLEC11A | -2.00e-02 | growth factor | NA | NA | 2.0e-02 | CCR5,CXCL12,FOS | NA |
| FUS | NA | transcription regulator | NA | NA | 2.0e-02 | CCND1,SLC19A3,SLC2A1 | NA |
| 9,10-dimethyl-1,2-benzanthracene | NA | chemical toxicant | NA | NA | 2.0e-02 | AHR,CCND1,CDKN1A | NA |
| SOD1 | 2.90e-01 | enzyme | NA | NA | 2.0e-02 | Casp12,CCND1,CRYAB,FOS,Mt1,RBM3,SLC40A1 | NA |
| EP4-D | NA | chemical reagent | NA | NA | 2.0e-02 | CARD11,SLC40A1,ZBTB16 | NA |
| PIM1 | -2.80e-01 | kinase | NA | NA | 2.0e-02 | CDKN1A,ERBB3,ID2 | NA |
| Ccl2 | -5.00e-02 | cytokine | NA | NA | 2.0e-02 | CCR5,CYBB,TLR4 | NA |
| lactosylceramide | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | TLR2,TNFRSF11A | NA |
| prostaglandin A1 | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | CDKN1A,NFKBIA | NA |
| sitagliptin | NA | chemical drug | NA | NA | 2.0e-02 | CXCL12,LGALS3 | NA |
| MAPK8IP1 | 1.30e-01 | other | NA | NA | 2.0e-02 | CCND1,FOS | NA |
| MAPK13 | 1.40e-01 | kinase | NA | NA | 2.0e-02 | CDKN1A,FOS | NA |
| miR-503-5p (miRNAs w/seed AGCAGCG) | NA | mature microRNA | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| KLF10 | -9.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| MAPK12 | -4.00e-02 | kinase | NA | NA | 2.0e-02 | CCND1,FOS | NA |
| ITGA9 | 2.60e-01 | other | NA | NA | 2.0e-02 | CDH11,CXCL12 | NA |
| ADRB3 | -1.00e-01 | G-protein coupled receptor | NA | NA | 2.0e-02 | CXCL12,FOS | NA |
| AXIN1 | NA | other | NA | NA | 2.0e-02 | CCND1,FOS | NA |
| SUV39H1 | NA | enzyme | NA | NA | 2.0e-02 | CDKN1A,CYTH4 | NA |
| HMGA2 | NA | enzyme | NA | NA | 2.0e-02 | CXCR4,ID2 | NA |
| apicidin | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | CDKN1A,ROR1 | NA |
| mezerein | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | CDKN1A,INSIG1 | NA |
| vismodegib | NA | chemical drug | NA | NA | 2.0e-02 | LGALS3,PTCH1,TNFRSF11B | NA |
| GIP | NA | other | NA | NA | 2.0e-02 | FOS,GBP5,Ifi47 | NA |
| EIF4EBP1 | 1.00e-01 | translation regulator | NA | NA | 2.0e-02 | CCND1,PNPLA2,SLC2A1 | NA |
| IL1R1 | -3.40e-01 | transmembrane receptor | NA | NA | 2.0e-02 | CXCL12,FOS,Slco1a4 | NA |
| nickel chloride | NA | chemical toxicant | NA | NA | 2.0e-02 | CRYAB,P4HA1,SLC2A1 | NA |
| heme | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | CYBB,LCN2,PER1 | NA |
| cysteinyl-leukotriene | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | FOS | NA |
| 2-methylthio-ATP | NA | chemical reagent | NA | NA | 2.0e-02 | FOS | NA |
| Npm | NA | group | NA | NA | 2.0e-02 | CDKN1A | NA |
| primidone | NA | chemical drug | NA | NA | 2.0e-02 | FOS | NA |
| arbutin | NA | chemical drug | NA | NA | 2.0e-02 | CDKN1A | NA |
| isopropyl thiogalactoside | NA | chemical reagent | NA | NA | 2.0e-02 | CCND1 | NA |
| ginsenoside Rh2 | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | FOS | NA |
| androgen receptor antagonist (S)-11 | NA | chemical reagent | NA | NA | 2.0e-02 | CCND1 | NA |
| androgen receptor antagonist (R)-9 | NA | chemical reagent | NA | NA | 2.0e-02 | CCND1 | NA |
| eleutherococcus senticosus extract | NA | chemical drug | NA | NA | 2.0e-02 | PNPLA2 | NA |
| KCN1 | NA | chemical reagent | NA | NA | 2.0e-02 | P4HA1 | NA |
| TRE-TTC2-1/2 | NA | group | NA | NA | 2.0e-02 | CDKN1A | NA |
| CERT1 | NA | kinase | NA | NA | 2.0e-02 | CCND1 | NA |
| lonaprisan | NA | chemical drug | NA | NA | 2.0e-02 | CCND1 | NA |
| chartreusin | NA | chemical reagent | NA | NA | 2.0e-02 | CDKN1A | NA |
| 4-nitrobenzoic acid | NA | chemical toxicant | NA | NA | 2.0e-02 | SLC2A1 | NA |
| glucose oxidase | NA | group | NA | NA | 2.0e-02 | SLC2A1 | NA |
| MSK1/2 | NA | group | NA | NA | 2.0e-02 | FOS | NA |
| PLA2 | NA | group | NA | NA | 2.0e-02 | FOS | NA |
| omethoate | NA | chemical toxicant | NA | NA | 2.0e-02 | CDKN1A | NA |
| CYP4A | NA | group | NA | NA | 2.0e-02 | SGK1 | NA |
| NPS | NA | other | NA | NA | 2.0e-02 | FOS | NA |
| nitrosomethylurethane | NA | chemical reagent | NA | NA | 2.0e-02 | CCND1 | NA |
| Rps15a-ps4 | NA | other | NA | NA | 2.0e-02 | NFKBIA | NA |
| USP42 | 3.00e-02 | peptidase | NA | NA | 2.0e-02 | CDKN1A | NA |
| FBXO31 | 2.30e-01 | enzyme | NA | NA | 2.0e-02 | CCND1 | NA |
| FAM168A | -5.00e-02 | other | NA | NA | 2.0e-02 | NFKBIA | NA |
| NSA2 | 3.30e-01 | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| FBXL12 | 2.60e-01 | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| PGC | NA | peptidase | NA | NA | 2.0e-02 | SFTPB | NA |
| FBXO25 | 4.00e-02 | enzyme | NA | NA | 2.0e-02 | FOS | NA |
| ZSCAN1 | NA | transcription regulator | NA | NA | 2.0e-02 | ADAMTS4 | NA |
| GFRAL | NA | transmembrane receptor | NA | NA | 2.0e-02 | PNPLA2 | NA |
| MAGEA2/MAGEA2B | NA | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| REM2 | -3.00e-02 | enzyme | NA | NA | 2.0e-02 | CCND1 | NA |
| RPRD1B | -4.00e-02 | other | NA | NA | 2.0e-02 | CCND1 | NA |
| CCDC88C | 2.60e-01 | other | NA | NA | 2.0e-02 | CCND1 | NA |
| OSI-027 | NA | chemical drug | NA | NA | 2.0e-02 | CCND1 | NA |
| ZBTB49 | 2.20e-01 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A | NA |
| SNRPA1 | 3.00e-01 | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| ADH5 | NA | enzyme | NA | NA | 2.0e-02 | LGALS3 | NA |
| VENTX | NA | transcription regulator | NA | NA | 2.0e-02 | CCND1 | NA |
| ZNF322 | -3.20e-01 | transcription regulator | NA | NA | 2.0e-02 | CCND1 | NA |
| RNF126 | 1.80e-01 | enzyme | NA | NA | 2.0e-02 | CDKN1A | NA |
| WDR13 | 4.00e-02 | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| BEST4 | NA | other | NA | NA | 2.0e-02 | CCND1 | NA |
| AGO3 | -1.50e-01 | translation regulator | NA | NA | 2.0e-02 | CXCR4 | NA |
| ETS-ELK1 | NA | complex | NA | NA | 2.0e-02 | CCND1 | NA |
| CTNNβ-LEF1 | NA | complex | NA | NA | 2.0e-02 | CCND1 | NA |
| Importin alpha | NA | group | NA | NA | 2.0e-02 | CDKN1A | NA |
| CBP-ICSBP-IRF-1-PU.1 | NA | complex | NA | NA | 2.0e-02 | CYBB | NA |
| OMG | 5.00e-02 | G-protein coupled receptor | NA | NA | 2.0e-02 | FOS | NA |
| INTERLEUKIN | NA | group | NA | NA | 2.0e-02 | FOS | NA |
| EIF4H | 1.60e-01 | translation regulator | NA | NA | 2.0e-02 | CCND1 | NA |
| RNMT | 1.00e-01 | enzyme | NA | NA | 2.0e-02 | CCND1 | NA |
| MCF2L | 0.00e+00 | other | NA | NA | 2.0e-02 | CCND1 | NA |
| AR-12 | NA | chemical drug | NA | NA | 2.0e-02 | LCN2 | NA |
| MAPK8IP2 | 8.00e-02 | other | NA | NA | 2.0e-02 | FOS | NA |
| DAPK3 | 8.00e-02 | kinase | NA | NA | 2.0e-02 | CCND1 | NA |
| RAC3 | 1.80e-01 | enzyme | NA | NA | 2.0e-02 | CCND1 | NA |
| MLIP | 2.50e-01 | transcription regulator | NA | NA | 2.0e-02 | SLC2A1 | NA |
| SYNJ1 | -1.40e-01 | phosphatase | NA | NA | 2.0e-02 | SLC2A1 | NA |
| miR-323-3p (and other miRNAs w/seed ACAUUAC) | NA | mature microRNA | NA | NA | 2.0e-02 | ERBB3 | NA |
| mir-663 | NA | microRNA | NA | NA | 2.0e-02 | CXCR4 | NA |
| ELAC2 | 6.00e-02 | enzyme | NA | NA | 2.0e-02 | CDKN1A | NA |
| SALL2 | -2.50e-01 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A | NA |
| CCNDBP1 | 1.00e-02 | other | NA | NA | 2.0e-02 | CCND1 | NA |
| PFN2 | NA | enzyme | NA | NA | 2.0e-02 | SLC40A1 | NA |
| MAGEA4 | NA | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| POLDIP3 | 1.00e-01 | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| SYNJ2BP | -2.50e-01 | other | NA | NA | 2.0e-02 | LFNG | NA |
| HPS1 | 1.60e-01 | other | NA | NA | 2.0e-02 | LGALS3 | NA |
| TSPYL2 | 2.10e-01 | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| PEX2 | -1.20e-01 | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| ARHGEF28 | 1.10e-01 | other | NA | NA | 2.0e-02 | FOS | NA |
| CCT5 | 3.40e-01 | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| GAD1 | 5.00e-02 | enzyme | NA | NA | 2.0e-02 | FOS | NA |
| NEK4 | -3.20e-01 | kinase | NA | NA | 2.0e-02 | CDKN1A | NA |
| FBXO4 | 1.00e-02 | enzyme | NA | NA | 2.0e-02 | CCND1 | NA |
| BCLAF1 | 7.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CCND1 | NA |
| PLEKHA1 | -7.00e-02 | other | NA | NA | 2.0e-02 | SLC2A1 | NA |
| POU4F3 | NA | transcription regulator | NA | NA | 2.0e-02 | FOS | NA |
| GABRG2 | -9.00e-02 | ion channel | NA | NA | 2.0e-02 | FOS | NA |
| KCNAB2 | 8.00e-02 | ion channel | NA | NA | 2.0e-02 | KCNA4 | NA |
| ADAMTS13 | -2.00e-02 | peptidase | NA | NA | 2.0e-02 | LGALS3 | NA |
| COMP | -2.40e-01 | other | NA | NA | 2.0e-02 | LGALS3 | NA |
| PGAM1 | 1.20e-01 | phosphatase | NA | NA | 2.0e-02 | CDKN1A | NA |
| AGO4 | NA | translation regulator | NA | NA | 2.0e-02 | CXCR4 | NA |
| Hsf4 | 1.10e-01 | transcription regulator | NA | NA | 2.0e-02 | CRYAB | NA |
| ING5 | NA | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| RAMP3 | 1.40e-01 | G-protein coupled receptor | NA | NA | 2.0e-02 | FOS | NA |
| PLEKHA2 | -1.00e-01 | other | NA | NA | 2.0e-02 | SLC2A1 | NA |
| TH | 1.80e-01 | enzyme | NA | NA | 2.0e-02 | FOS | NA |
| KHDRBS2 | 5.00e-02 | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| cycloastragenol | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | CDKN1A | NA |
| GALR2 | 1.00e-01 | G-protein coupled receptor | NA | NA | 2.0e-02 | CDKN1A | NA |
| DPH1 | 0.00e+00 | enzyme | NA | NA | 2.0e-02 | CCND1 | NA |
| STAMBP | 2.30e-01 | enzyme | NA | NA | 2.0e-02 | CXCR4 | NA |
| PDHA1 | 1.10e-01 | enzyme | NA | NA | 2.0e-02 | CCND1 | NA |
| PCBP4 | 2.50e-01 | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| GRAP | -1.10e-01 | other | NA | NA | 2.0e-02 | FOS | NA |
| 2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide | NA | chemical reagent | NA | NA | 2.0e-02 | AURKB | NA |
| MMUT | NA | enzyme | NA | NA | 2.0e-02 | LCN2 | NA |
| CGGBP1 | -2.00e-01 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A | NA |
| UBE2V1 | 1.20e-01 | transcription regulator | NA | NA | 2.0e-02 | FOS | NA |
| EVC | 9.00e-02 | other | NA | NA | 2.0e-02 | PTCH1 | NA |
| GABRA2 | -1.30e-01 | ion channel | NA | NA | 2.0e-02 | TLR4 | NA |
| CRTAP | NA | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| Bhlhe41 | 4.00e-01 | transcription regulator | NA | NA | 2.0e-02 | PER1 | NA |
| Cops2 | 1.20e-01 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A | NA |
| CCL3L1 | NA | other | NA | NA | 2.0e-02 | CCR5 | NA |
| INTU | NA | other | NA | NA | 2.0e-02 | PTCH1 | NA |
| CLEC2D | NA | transmembrane receptor | NA | NA | 2.0e-02 | CXCR4 | NA |
| MI-63 | NA | chemical reagent | NA | NA | 2.0e-02 | CDKN1A | NA |
| ZFYVE16 | -3.10e-01 | other | NA | NA | 2.0e-02 | CDKN1A | NA |
| 1,5-bis-(dihexyl-N-nitrosoamino)-2,4-dinitrobenzene | NA | chemical reagent | NA | NA | 2.0e-02 | CYBB | NA |
| USP17L | NA | group | NA | NA | 2.0e-02 | CDKN1A | NA |
| indotecan | NA | chemical drug | NA | NA | 2.0e-02 | SLC2A1 | NA |
| sorafenib derivative SC-1 | NA | chemical reagent | NA | NA | 2.0e-02 | CCND1 | NA |
| securinine | NA | chemical reagent | NA | NA | 2.0e-02 | CDKN1A | NA |
| 8-aminoadenosine | NA | chemical reagent | NA | NA | 2.0e-02 | SLC2A1 | NA |
| polyethylene glycol | NA | chemical drug | NA | NA | 2.0e-02 | CDKN1A | NA |
| 2,2-(2-chlorophenyl-4’-chlorophenyl)-1,1-dichloroethene | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | AHR | NA |
| 1-(3-chlorophenyl)piperazine | NA | chemical drug | NA | NA | 2.0e-02 | FOS | NA |
| NPC 15437 | NA | chemical drug | NA | NA | 2.0e-02 | FOS | NA |
| telomestatin | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | CDKN1A | NA |
| bunazosin | NA | chemical drug | NA | NA | 2.0e-02 | CCND1 | NA |
| phosphorylethanolamine | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | CCND1 | NA |
| inostamycin | NA | chemical reagent | NA | NA | 2.0e-02 | CCND1 | NA |
| kynurenic acid | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | CDKN1A | NA |
| quiflapon | NA | chemical reagent | NA | NA | 2.0e-02 | LCN2 | NA |
| amlexanox | NA | chemical drug | NA | NA | 2.0e-02 | CCND1 | NA |
| imidapril | NA | chemical drug | NA | NA | 2.0e-02 | NCF1 | NA |
| furegrelate | NA | chemical reagent | NA | NA | 2.0e-02 | NR0B1 | NA |
| dicumarol | NA | chemical drug | NA | NA | 2.0e-02 | Mt1 | NA |
| sepiapterin | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | LCN2 | NA |
| hexaarginine-neomycin B conjugate | NA | chemical reagent | NA | NA | 2.0e-02 | CXCR4 | NA |
| AG-270 | NA | chemical drug | NA | NA | 2.0e-02 | FOS | NA |
| (S)-flurbiprofen | NA | chemical drug | NA | NA | 2.0e-02 | CCND1 | NA |
| pamidronic acid | NA | chemical drug | NA | NA | 2.0e-02 | TNFRSF11B | NA |
| chlordiazepoxide | NA | chemical drug | NA | NA | 2.0e-02 | FOS | NA |
| GYKI 52466 | NA | chemical drug | NA | NA | 2.0e-02 | FOS | NA |
| 1-o-hexadecyl-2-o-methyl-rac-glycerol | NA | chemical - kinase inhibitor | NA | NA | 2.0e-02 | CDKN1A | NA |
| gliclazide | NA | chemical drug | NA | NA | 2.0e-02 | SLC2A1 | NA |
| (S)-2-((6Z,15Z)-20- hydroxyicosa-6,15-dienamido)succinate | NA | chemical reagent | NA | NA | 2.0e-02 | SGK1 | NA |
| 5,5-dimethyl-1-pyrroline-1-oxide | NA | chemical reagent | NA | NA | 2.0e-02 | FOS | NA |
| biliverdine | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | TLR4 | NA |
| pca 4230 | NA | chemical reagent | NA | NA | 2.0e-02 | CCND1 | NA |
| nisoldipine | NA | chemical drug | NA | NA | 2.0e-02 | FOS | NA |
| hdm-2 antagonistic peptide | NA | chemical reagent | NA | NA | 2.0e-02 | CDKN1A | NA |
| NAB2-STAT6 | NA | fusion gene/product | NA | NA | 2.0e-02 | CCND1 | NA |
| GSK2656157 | NA | chemical drug | NA | NA | 2.0e-02 | ERBB3 | NA |
| (-)-epigallocatechin-3-O-(3’’-O-methyl)-gallate | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | TLR4 | NA |
| tegaserod | NA | chemical drug | NA | NA | 2.0e-02 | FOS | NA |
| veratridine | NA | chemical toxicant | NA | NA | 2.0e-02 | FOS | NA |
| teleocidins | NA | chemical toxicant | NA | NA | 2.0e-02 | FOS | NA |
| vinflunine | NA | chemical drug | NA | NA | 2.0e-02 | CDKN1A | NA |
| D-lysergic acid diethylamide | NA | chemical drug | NA | NA | 2.0e-02 | SGK1 | NA |
| 5-oxo-6-8-11-14-(e,z,z,z)-eicosatetraenoic acid | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | ENPP3 | NA |
| N(omega)-hydroxyarginine | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | CDKN1A | NA |
| 5-thio-D-glucose | NA | chemical reagent | NA | NA | 2.0e-02 | FOS | NA |
| arylsulfonamide 64B | NA | chemical reagent | NA | NA | 2.0e-02 | CXCR4 | NA |
| isosakuranetin | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | FOS | NA |
| LATS2 | -2.80e-01 | kinase | NA | NA | 2.0e-02 | AURKB,CDKN1A,ERBB3 | NA |
| EHMT2 | -1.10e-01 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A,CXCL12,Tcam1 | NA |
| Pkg | NA | group | NA | NA | 2.0e-02 | FOS,SLC2A1 | NA |
| ETS | NA | group | NA | NA | 2.0e-02 | CCND1,FOS | NA |
| PDGF-DD | NA | complex | NA | NA | 2.0e-02 | Casp12,PGF | NA |
| FAM3B | -1.90e-01 | cytokine | NA | NA | 2.0e-02 | CDKN1A,LCN2 | NA |
| HTATIP2 | -1.40e-01 | transcription regulator | NA | NA | 2.0e-02 | CCND1,FOS | NA |
| CYP2E1 | -1.00e-02 | enzyme | NA | NA | 2.0e-02 | NCF1,TLR4 | NA |
| CD200 | 4.00e-02 | other | NA | NA | 2.0e-02 | TLR2,TLR4 | NA |
| CDH2 | 3.00e-02 | other | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| FSHB | NA | other | NA | NA | 2.0e-02 | KITLG,SGK1 | NA |
| silicon dioxide | NA | chemical drug | NA | NA | 2.0e-02 | FOS,NCF1 | NA |
| desipramine | NA | chemical drug | NA | NA | 2.0e-02 | CDKN1A,FOS | NA |
| beta-glycerophosphoric acid | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | CDKN1A,TNFRSF11B | NA |
| diallyl trisulfide | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | CDKN1A,FOS | NA |
| DL-fructose | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | GPD1,TLR4 | NA |
| Zn2+ | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | FOS,Mt1 | NA |
| adenosine | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | CXCR4,FOS,TLR4 | NA |
| NCOR2 | -5.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CCND1,CDKN1A,FOS | NA |
| dexmedetomidine | NA | chemical drug | NA | NA | 2.0e-02 | CDKN1A,FOS,TLR2 | NA |
| alvespimycin | NA | chemical drug | NA | NA | 2.0e-02 | CCND1,ERBB3 | NA |
| trastuzumab | NA | biologic drug | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| SAV1 | -9.00e-02 | other | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| TOX | 1.00e-02 | transcription regulator | NA | NA | 2.0e-02 | AHR,ID2 | NA |
| SULF2 | 2.20e-01 | enzyme | NA | NA | 2.0e-02 | CCND1,POSTN | NA |
| KDM4A | 5.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| AURKA | 2.00e-01 | kinase | NA | NA | 2.0e-02 | CDKN1A,SLC2A1 | NA |
| miR-18a-5p (and other miRNAs w/seed AAGGUGC) | NA | mature microRNA | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| UCN | -1.70e-01 | other | NA | NA | 2.0e-02 | FOS,TLR4 | NA |
| HDAC7 | -7.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| RLN2 | NA | other | NA | NA | 2.0e-02 | FOS,TLR4 | NA |
| TGFB1I1 | 9.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A,FOS | NA |
| NTRK1 | 2.00e-01 | kinase | NA | NA | 2.0e-02 | CDKN1A,FOS | NA |
| DYRK1A | 9.00e-02 | kinase | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| Cdkn1c | -1.00e-01 | other | NA | NA | 2.0e-02 | CDKN1A,CXCR4 | NA |
| Mt2 | NA | other | NA | NA | 2.0e-02 | CCND1,FOS | NA |
| paroxetine | NA | chemical drug | NA | NA | 2.0e-02 | ID2,RBM12B | NA |
| S-(2,3-bispalmitoyloxypropyl)-cysteine-GDPKHPKSF | NA | chemical reagent | NA | NA | 2.0e-02 | SLC40A1,TLR2 | NA |
| chelerythrine | NA | chemical drug | NA | NA | 2.0e-02 | CYBB,NFKBIA | NA |
| nickel | NA | chemical toxicant | NA | NA | 2.0e-02 | FOS,Mt1 | NA |
| emodin | NA | chemical drug | NA | NA | 2.0e-02 | CDKN1A,CXCR4,TLR4 | NA |
| EHMT1 | -5.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A,LCN2,SH3TC1,Tcam1 | NA |
| plumbagin | NA | chemical drug | NA | NA | 2.0e-02 | CCND1,CYBB | NA |
| E2F5 | -1.20e-01 | transcription regulator | NA | NA | 2.0e-02 | AURKB,CDKN1A | NA |
| CCL3 | NA | cytokine | NA | NA | 2.0e-02 | CCR5,FOS | NA |
| FGF4 | NA | growth factor | NA | NA | 2.0e-02 | CDKN1A,FOS | NA |
| SLPI | NA | other | NA | NA | 2.0e-02 | CCND1,NFKBIA | NA |
| TNFRSF11B | -7.80e-01 | transmembrane receptor | NA | NA | 2.0e-02 | TNFRSF11A,TNFRSF11B | NA |
| HSD17B4 | -1.00e-01 | enzyme | NA | NA | 2.0e-02 | PEX11A,PTCH1 | NA |
| PD184352 | NA | chemical drug | NA | NA | 2.0e-02 | CCND1,FOS | NA |
| aphidicolin | NA | chemical toxicant | NA | NA | 2.0e-02 | CDKN1A,MYH6 | NA |
| RSL3 | NA | chemical reagent | NA | NA | 2.0e-02 | CXCR4,LCN2 | NA |
| UCN-01 | NA | chemical drug | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| creatine | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | TLR2,TLR4 | NA |
| tributyrin | NA | chemical drug | NA | NA | 2.0e-02 | CDKN1A,CXCR4,ID2 | NA |
| BSCL2 | 1.40e-01 | other | NA | NA | 2.0e-02 | CCND1,GPD1,PNPLA2 | NA |
| PPP2CA | -6.00e-02 | phosphatase | NA | NA | 2.0e-02 | AHR,CCND1,CDKN1A | NA |
| miR-182-5p (and other miRNAs w/seed UUGGCAA) | NA | mature microRNA | NA | NA | 2.0e-02 | CARD11,GADD45G,PGF | NA |
| CD200R1 | -1.00e-01 | transmembrane receptor | NA | NA | 2.0e-02 | CCR5,NFKBIA,TGFB3 | NA |
| sulindac | NA | chemical drug | NA | NA | 2.0e-02 | CCND1,CDKN1A,ERBB3 | NA |
| arsenite | NA | chemical toxicant | NA | NA | 2.0e-02 | AHR,CCND1,CDKN1A,FOS | NA |
| 1,25-dihydroxyvitamin D | NA | chemical drug | NA | NA | 2.0e-02 | CCND1,TLR2,TLR4 | NA |
| SGK1 | 7.60e-01 | kinase | NA | NA | 2.0e-02 | CDKN1A,KCNA4,SLC34A2 | NA |
| resolvin E1 | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | CCR5,TNFRSF11B | NA |
| PDGF-AA | NA | complex | NA | NA | 2.0e-02 | CDKN1A,FOS | NA |
| Smad | NA | complex | NA | NA | 2.0e-02 | CDKN1A,ID2 | NA |
| BAHCC1 | -9.00e-02 | other | NA | NA | 2.0e-02 | CDKN1A,PTCH1 | NA |
| RNF20 | -1.40e-01 | enzyme | NA | NA | 2.0e-02 | CDKN1A,FOS | NA |
| CDC73 | -2.40e-01 | other | NA | NA | 2.0e-02 | CCND1,LGALS3 | NA |
| MIR31HG | NA | other | NA | NA | 2.0e-02 | CDKN1A,TNFRSF11B | NA |
| MST1 | 1.00e-02 | growth factor | NA | NA | 2.0e-02 | CCND1,FOS | NA |
| Trp53cor1 | NA | other | NA | NA | 2.0e-02 | CDKN1A,FZD10 | NA |
| STK4 | -3.00e-02 | kinase | NA | NA | 2.0e-02 | NFKBIA,SFTPB | NA |
| JARID2 | -3.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| USP19 | -7.00e-02 | peptidase | NA | NA | 2.0e-02 | FKBP5,LCN2 | NA |
| NOS1 | -1.40e-01 | enzyme | NA | NA | 2.0e-02 | FOS,SLC2A1 | NA |
| PLK2 | 1.00e-02 | kinase | NA | NA | 2.0e-02 | MERTK,RGS1 | NA |
| PARP2 | -1.00e-01 | enzyme | NA | NA | 2.0e-02 | CCR5,SFTPB | NA |
| FOXF2 | NA | transcription regulator | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| AZGP1 | 1.00e-02 | transporter | NA | NA | 2.0e-02 | CCND1,PNPLA2 | NA |
| aristolochic acid I | NA | chemical toxicant | NA | NA | 2.0e-02 | CDKN1A,FOS | NA |
| arotinoid acid | NA | chemical toxicant | NA | NA | 2.0e-02 | CDKN1A,FOS | NA |
| immethridine | NA | chemical reagent | NA | NA | 2.0e-02 | CCR5,LCN2 | NA |
| dactolisib | NA | chemical drug | NA | NA | 2.0e-02 | CDKN1A,ERBB3,P4HA1 | NA |
| HAND2 | 3.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CXCR4,GJA5,MYH6 | NA |
| BACH1 | -1.00e-01 | transcription regulator | NA | NA | 3.0e-02 | CXCR4,HIF3A,SLC40A1 | NA |
| Gcg | NA | other | NA | NA | 3.0e-02 | FOS,MFSD2A,PEX11A | NA |
| 3,3’-diindolylmethane | NA | chemical drug | NA | NA | 3.0e-02 | CCND1,CDKN1A,NFKBIA | NA |
| GLI2 | -2.50e-01 | transcription regulator | NA | NA | 3.0e-02 | CCND1,CCR5,CDKN1A,PTCH1 | NA |
| Z36 | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A,INSIG1 | NA |
| picrotoxin | NA | chemical toxicant | NA | NA | 3.0e-02 | ADCY4,FOS | NA |
| CD300LF | -4.60e-01 | other | NA | NA | 3.0e-02 | GPD1,SLC2A1 | NA |
| BMP | NA | group | NA | NA | 3.0e-02 | ERBB3,ID2 | NA |
| thyroid hormone receptor | NA | group | NA | NA | 3.0e-02 | EHHADH,FOS | NA |
| enzalutamide | NA | chemical drug | NA | NA | 3.0e-02 | DOCK8,FKBP5 | NA |
| TF | 1.20e-01 | transporter | NA | NA | 3.0e-02 | CCND1,NFKBIA | NA |
| mir-9 | NA | microRNA | NA | NA | 3.0e-02 | CXCR4,RUNX1T1 | NA |
| SOX6 | -1.60e-01 | transcription regulator | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| TRPC1 | NA | ion channel | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| NFIX | NA | transcription regulator | NA | NA | 3.0e-02 | CCND1,POSTN | NA |
| XIAP | -2.00e-01 | enzyme | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| LTF | NA | peptidase | NA | NA | 3.0e-02 | CDKN1A,TNFRSF11B | NA |
| FGF9 | -3.70e-01 | growth factor | NA | NA | 3.0e-02 | CCND1,PTCH1 | NA |
| ERF | 1.10e-01 | transcription regulator | NA | NA | 3.0e-02 | NOTCH4,WNT7A | NA |
| PLK4 | 3.50e-01 | kinase | NA | NA | 3.0e-02 | MERTK,RGS1 | NA |
| 4-nitroquinoline-1-oxide | NA | chemical toxicant | NA | NA | 3.0e-02 | AURKB,CDKN1A | NA |
| calyculin A | NA | chemical toxicant | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| cyanocobalamin | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | PER1,PTCH1 | NA |
| octreotide | NA | biologic drug | NA | NA | 3.0e-02 | CDKN1A,FOS | NA |
| kaempferol | NA | chemical toxicant | NA | NA | 3.0e-02 | CDKN1A,CXCL12 | NA |
| PRKCB | 1.00e-02 | kinase | NA | NA | 3.0e-02 | CCND1,CDKN1A,FOS | NA |
| DOCK8 | -8.30e-01 | other | NA | NA | 3.0e-02 | HELZ2,MERTK,RGS1 | NA |
| PAX5 | -1.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CCND1,CNR2,SLC2A1 | NA |
| POU2F1 | -1.40e-01 | transcription regulator | NA | NA | 3.0e-02 | CCND1,HOMER3,RPE65,TLR4 | NA |
| TARDBP | NA | transcription regulator | NA | NA | 3.0e-02 | C1QB,INSIG1,LCN2,SLC19A3 | NA |
| UTP | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | KCNA4,TLR4 | NA |
| ZNF503 | 5.00e-02 | other | NA | NA | 3.0e-02 | MERTK,RPE65 | NA |
| ZIC1 | -2.40e-01 | transcription regulator | NA | NA | 3.0e-02 | CCND1,WNT7A | NA |
| GPNMB | 8.00e-02 | enzyme | NA | NA | 3.0e-02 | FOS,TNFRSF11A | NA |
| MC4R | -3.30e-01 | G-protein coupled receptor | NA | NA | 3.0e-02 | FOS,PNPLA2 | NA |
| REN | 3.00e-02 | peptidase | NA | NA | 3.0e-02 | FOS,MYH6 | NA |
| BTRC | 2.00e-02 | enzyme | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| MAP2K2 | 1.30e-01 | kinase | NA | NA | 3.0e-02 | CDKN1A,FOS | NA |
| CRYAB | 7.60e-01 | other | NA | NA | 3.0e-02 | CCND1,CRYAB | NA |
| P2RY2 | -1.30e-01 | G-protein coupled receptor | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| SLC2A1 | 6.30e-01 | transporter | NA | NA | 3.0e-02 | DHRS9,SLC2A1 | NA |
| SFN | 1.40e-01 | other | NA | NA | 3.0e-02 | FKBP5,SGK1 | NA |
| BMPR1B | NA | kinase | NA | NA | 3.0e-02 | CDKN1A,POSTN | NA |
| CCR1 | -2.50e-01 | G-protein coupled receptor | NA | NA | 3.0e-02 | FOS,TNFRSF11A | NA |
| TFPI2 | -4.80e-01 | other | NA | NA | 3.0e-02 | ADAMTS4,CCND1 | NA |
| HEY1 | 4.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,MYH6 | NA |
| Elf5 | -5.00e-02 | transcription regulator | NA | NA | 3.0e-02 | ENDOU,ENPP3 | NA |
| WTAP | -4.00e-02 | other | NA | NA | 3.0e-02 | ADCY4,PNPLA2 | NA |
| SL 327 | NA | chemical - protease inhibitor | NA | NA | 3.0e-02 | CA12,FOS | NA |
| MALP-2s | NA | chemical reagent | NA | NA | 3.0e-02 | TLR2,TLR4 | NA |
| titanium dioxide | NA | chemical drug | NA | NA | 3.0e-02 | CDKN1A,CRYAB | NA |
| phorbol 12,13-didecanoate | NA | chemical toxicant | NA | NA | 3.0e-02 | CDKN1A,SGK1 | NA |
| progestin | NA | chemical drug | NA | NA | 3.0e-02 | CCND1,NFKBIA | NA |
| compound SI-1 | NA | chemical reagent | NA | NA | 3.0e-02 | FKBP5 | NA |
| compound SI-2 | NA | chemical reagent | NA | NA | 3.0e-02 | FKBP5 | NA |
| [(R)-6-(4-(4-benzyl-7-chloronaphthalen-1-yl)-2-methylpiperazin-1-yl)] nicotine nitrile | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A | NA |
| lopinavir | NA | chemical drug | NA | NA | 3.0e-02 | TNFRSF11B | NA |
| HS-243 | NA | chemical - kinase inhibitor | NA | NA | 3.0e-02 | CXCL12 | NA |
| mycosporine-like amino acid | NA | chemical reagent | NA | NA | 3.0e-02 | FOS | NA |
| R2HBJJ | NA | chemical reagent | NA | NA | 3.0e-02 | CCND1 | NA |
| mineralocorticoid | NA | chemical drug | NA | NA | 3.0e-02 | SGK1 | NA |
| Osteocalcin | NA | group | NA | NA | 3.0e-02 | CCND1 | NA |
| extremely high molecular weight hyaluronic acid | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A | NA |
| LLL12B | NA | chemical reagent | NA | NA | 3.0e-02 | CCND1 | NA |
| beryllium sulfate | NA | chemical toxicant | NA | NA | 3.0e-02 | CDKN1A | NA |
| H. carbonum toxin | NA | biologic drug | NA | NA | 3.0e-02 | CDKN1A | NA |
| (diaminocyclohexane)(diacetato)(dichloro)platinum | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A | NA |
| WDR82 | -1.00e-01 | enzyme | NA | NA | 3.0e-02 | CDKN1A | NA |
| PTCHD4 | -4.20e-01 | other | NA | NA | 3.0e-02 | PTCH1 | NA |
| myosin-light-chain kinase | NA | group | NA | NA | 3.0e-02 | CCND1 | NA |
| FKHR | NA | group | NA | NA | 3.0e-02 | CCND1 | NA |
| TFIIH | NA | complex | NA | NA | 3.0e-02 | CDKN1A | NA |
| Stat1-Stat3 | NA | complex | NA | NA | 3.0e-02 | FOS | NA |
| Esr1-Estrogen-Sp1 | NA | complex | NA | NA | 3.0e-02 | FOS | NA |
| cetylpyridinium | NA | chemical drug | NA | NA | 3.0e-02 | FOS | NA |
| D-4476 | NA | chemical drug | NA | NA | 3.0e-02 | PER1 | NA |
| MLN8054 | NA | chemical drug | NA | NA | 3.0e-02 | CDKN1A | NA |
| ACTA2-AS1 | NA | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| 3,4’,5-trimethoxystilbene | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A | NA |
| SLC48A1 | 9.00e-02 | transporter | NA | NA | 3.0e-02 | SLC2A1 | NA |
| MAGEA11 | NA | other | NA | NA | 3.0e-02 | FKBP5 | NA |
| ZNF346 | 0.00e+00 | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| ZNF276 | 1.50e-01 | transcription regulator | NA | NA | 3.0e-02 | CCND1 | NA |
| RHOBTB2 | -3.80e-01 | enzyme | NA | NA | 3.0e-02 | CDKN1A | NA |
| RFFL | -4.20e-01 | enzyme | NA | NA | 3.0e-02 | CDKN1A | NA |
| TTC5 | 4.00e-02 | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| ADRM1 | 2.40e-01 | other | NA | NA | 3.0e-02 | NFKBIA | NA |
| CNPY3 | 2.20e-01 | other | NA | NA | 3.0e-02 | TLR4 | NA |
| PTPMT1 | 2.30e-01 | phosphatase | NA | NA | 3.0e-02 | CDKN1A | NA |
| NIBAN2 | NA | transcription regulator | NA | NA | 3.0e-02 | CCND1 | NA |
| NOP58 | -5.00e-02 | enzyme | NA | NA | 3.0e-02 | CCND1 | NA |
| AKIP1 | 3.70e-01 | other | NA | NA | 3.0e-02 | NFKBIA | NA |
| OR51E1 | NA | G-protein coupled receptor | NA | NA | 3.0e-02 | CDKN1A | NA |
| ZNF451 | 2.00e-01 | enzyme | NA | NA | 3.0e-02 | CDKN1A | NA |
| NDUFAF3 | 1.10e-01 | other | NA | NA | 3.0e-02 | CCND1 | NA |
| C1QL1 | 2.30e-01 | other | NA | NA | 3.0e-02 | FOS | NA |
| avexitide | NA | biologic drug | NA | NA | 3.0e-02 | FOS | NA |
| PSMD14 | 1.20e-01 | peptidase | NA | NA | 3.0e-02 | CCND1 | NA |
| potassium channel | NA | group | NA | NA | 3.0e-02 | FOS | NA |
| N4BP2L2 | -3.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A | NA |
| OXGR1 | NA | G-protein coupled receptor | NA | NA | 3.0e-02 | PNPLA2 | NA |
| ITGBL1 | -3.50e-01 | other | NA | NA | 3.0e-02 | CDH11 | NA |
| RNF32-DT | NA | other | NA | NA | 3.0e-02 | CCND1 | NA |
| CP | -1.10e-01 | enzyme | NA | NA | 3.0e-02 | SLC40A1 | NA |
| CTBP1-DT | NA | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| LUZP1 | -3.70e-01 | other | NA | NA | 3.0e-02 | PTCH1 | NA |
| KLHL2 | 6.00e-02 | other | NA | NA | 3.0e-02 | CCND1 | NA |
| DSTYK | -1.10e-01 | kinase | NA | NA | 3.0e-02 | CCND1 | NA |
| OSR2 | -1.00e-02 | transcription regulator | NA | NA | 3.0e-02 | TGFB3 | NA |
| TRPM3 | -1.40e-01 | ion channel | NA | NA | 3.0e-02 | FOS | NA |
| EXOC3L1 | -7.00e-02 | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| KLHL21 | 1.10e-01 | enzyme | NA | NA | 3.0e-02 | NFKBIA | NA |
| TCF4-CTNNβ | NA | complex | NA | NA | 3.0e-02 | ID2 | NA |
| Aldosterone-MR dimer | NA | complex | NA | NA | 3.0e-02 | SGK1 | NA |
| GPD1L | -1.70e-01 | enzyme | NA | NA | 3.0e-02 | SLC2A1 | NA |
| methylamphotericin B | NA | chemical drug | NA | NA | 3.0e-02 | LCN2 | NA |
| UBE2D3 | 0.00e+00 | enzyme | NA | NA | 3.0e-02 | CCND1 | NA |
| ATP1A2 | -1.70e-01 | transporter | NA | NA | 3.0e-02 | FOS | NA |
| Gap | NA | group | NA | NA | 3.0e-02 | FOS | NA |
| CSNK1E | 3.00e-02 | kinase | NA | NA | 3.0e-02 | PER1 | NA |
| YEATS4 | 3.10e-01 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A | NA |
| RNF144B | 6.00e-02 | enzyme | NA | NA | 3.0e-02 | CDKN1A | NA |
| SRGAP1 | -2.50e-01 | other | NA | NA | 3.0e-02 | CCND1 | NA |
| TERF1 | 9.00e-02 | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| SERTAD1 | 1.10e-01 | transcription regulator | NA | NA | 3.0e-02 | CCND1 | NA |
| GPC3 | 4.00e-02 | other | NA | NA | 3.0e-02 | CCND1 | NA |
| MPRIP | -3.00e-02 | other | NA | NA | 3.0e-02 | TLR4 | NA |
| RRAD | 4.00e-02 | enzyme | NA | NA | 3.0e-02 | CCND1 | NA |
| MAT2B | 5.00e-02 | enzyme | NA | NA | 3.0e-02 | CCND1 | NA |
| PLEC | -1.80e-01 | other | NA | NA | 3.0e-02 | CXCR4 | NA |
| PMEPA1 | 4.00e-02 | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| HPGD | 1.00e-01 | enzyme | NA | NA | 3.0e-02 | CDKN1A | NA |
| SEMA3D | 2.00e-02 | other | NA | NA | 3.0e-02 | CCND1 | NA |
| SDCBP2-AS1 | NA | other | NA | NA | 3.0e-02 | CCND1 | NA |
| YARS1 | NA | enzyme | NA | NA | 3.0e-02 | NFKBIA | NA |
| AGAP2 | 7.00e-02 | enzyme | NA | NA | 3.0e-02 | CCND1 | NA |
| MCRS1 | 2.00e-01 | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| miR-424-3p (miRNAs w/seed AAAACGU) | NA | mature microRNA | NA | NA | 3.0e-02 | LGALS3 | NA |
| ARHGAP1 | -8.00e-02 | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| aurora kinase inhibitor III | NA | chemical - kinase inhibitor | NA | NA | 3.0e-02 | FOS | NA |
| SGI 1776 | NA | chemical drug | NA | NA | 3.0e-02 | CCND1 | NA |
| RALGDS | 3.80e-01 | other | NA | NA | 3.0e-02 | CCND1 | NA |
| MGAT4A | -1.50e-01 | enzyme | NA | NA | 3.0e-02 | CCND1 | NA |
| EIF2B1 | 2.40e-01 | translation regulator | NA | NA | 3.0e-02 | CCND1 | NA |
| SRCAP | -1.40e-01 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A | NA |
| EID2 | 6.00e-02 | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| KIF23 | 0.00e+00 | other | NA | NA | 3.0e-02 | CCND1 | NA |
| PTTG1IP | 3.00e-02 | other | NA | NA | 3.0e-02 | CCND1 | NA |
| TOR2A | -1.60e-01 | other | NA | NA | 3.0e-02 | FOS | NA |
| SRPK2 | -9.00e-02 | kinase | NA | NA | 3.0e-02 | CCND1 | NA |
| SYF2 | 2.90e-01 | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| GCNT1 | -3.40e-01 | enzyme | NA | NA | 3.0e-02 | FOS | NA |
| DDX24 | 3.80e-01 | enzyme | NA | NA | 3.0e-02 | CDKN1A | NA |
| PDZD2 | -3.50e-01 | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| MXD4 | NA | transcription regulator | NA | NA | 3.0e-02 | ID2 | NA |
| CTAG1A/CTAG1B | NA | other | NA | NA | 3.0e-02 | CCND1 | NA |
| TRERF1 | -4.60e-01 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A | NA |
| SPAG9 | -8.00e-02 | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| JAGN1 | 1.40e-01 | other | NA | NA | 3.0e-02 | CSF3R | NA |
| S100A2 | NA | other | NA | NA | 3.0e-02 | SLC2A1 | NA |
| AP2A2 | 5.00e-02 | transporter | NA | NA | 3.0e-02 | CDKN1A | NA |
| UPP1 | 2.00e-01 | enzyme | NA | NA | 3.0e-02 | EHHADH | NA |
| CDK5R2 | 3.00e-02 | other | NA | NA | 3.0e-02 | FOS | NA |
| mir-467 | NA | microRNA | NA | NA | 3.0e-02 | Podxl | NA |
| HES6 | 4.20e-01 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A | NA |
| PES1 | 1.30e-01 | other | NA | NA | 3.0e-02 | CCND1 | NA |
| ERCC6 | 6.00e-02 | transcription regulator | NA | NA | 3.0e-02 | LGALS3 | NA |
| ERC1 | -3.30e-01 | other | NA | NA | 3.0e-02 | NFKBIA | NA |
| ARHGEF11 | -1.50e-01 | other | NA | NA | 3.0e-02 | FOS | NA |
| BUB3 | 2.50e-01 | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| TCP1 | 1.50e-01 | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| 8-butyl-10-[(3-methoxy-5-pyrrol-2-ylidenepyrrol-2-ylidene)methyl]-11-azabicyclo[7.2.1]dodeca-1(12),9-diene | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A | NA |
| MXD3 | 1.80e-01 | transcription regulator | NA | NA | 3.0e-02 | ID2 | NA |
| EXOSC10 | 9.00e-02 | kinase | NA | NA | 3.0e-02 | FOS | NA |
| RPL37 | NA | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| Hspa1b | NA | enzyme | NA | NA | 3.0e-02 | FOS | NA |
| CYP2C9 | 3.00e-02 | enzyme | NA | NA | 3.0e-02 | CCND1 | NA |
| TTF1 | NA | transcription regulator | NA | NA | 3.0e-02 | SFTPB | NA |
| H1-1 | NA | other | NA | NA | 3.0e-02 | FOS | NA |
| RDH16 | -1.00e-02 | enzyme | NA | NA | 3.0e-02 | CCND1 | NA |
| (+)-R-3-(4-chlorophenyl)-3-(1-hydroxymethylcyclopropylmethoxy)-2-(4-nitrobenzyl)-2,3-dihydroisoindol-1-one | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A | NA |
| ATAD2 | 5.00e-02 | enzyme | NA | NA | 3.0e-02 | CCND1 | NA |
| UIMC1 | -1.90e-01 | other | NA | NA | 3.0e-02 | CDKN1A | NA |
| HILPDA | 9.00e-02 | other | NA | NA | 3.0e-02 | PNPLA2 | NA |
| DUOX2 | 1.70e-01 | enzyme | NA | NA | 3.0e-02 | CDKN1A | NA |
| (E)-1-(2-nitrovinyl)naphthalene | NA | chemical reagent | NA | NA | 3.0e-02 | CCND1 | NA |
| (E)-9-(2-nitrovinyl)anthracene | NA | chemical reagent | NA | NA | 3.0e-02 | CCND1 | NA |
| beta2 adrenergic receptor agonist | NA | chemical drug | NA | NA | 3.0e-02 | CDKN1A | NA |
| O-(chloroacetylcarbamoyl)fumagillol | NA | chemical drug | NA | NA | 3.0e-02 | CDKN1A | NA |
| anastrozole | NA | chemical drug | NA | NA | 3.0e-02 | TNFRSF11B | NA |
| nitrous oxide | NA | chemical drug | NA | NA | 3.0e-02 | FOS | NA |
| mecamylamine | NA | chemical drug | NA | NA | 3.0e-02 | FOS | NA |
| amantadine | NA | chemical drug | NA | NA | 3.0e-02 | FOS | NA |
| dephostatin | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A | NA |
| cilomilast | NA | chemical drug | NA | NA | 3.0e-02 | CXCR4 | NA |
| GSK-3beta inhibitor II | NA | chemical drug | NA | NA | 3.0e-02 | CDKN1A | NA |
| p-chloroamphetamine | NA | chemical drug | NA | NA | 3.0e-02 | FOS | NA |
| neratinib | NA | chemical drug | NA | NA | 3.0e-02 | CCND1 | NA |
| RX-821002 | NA | chemical reagent | NA | NA | 3.0e-02 | FOS | NA |
| oxotremorine | NA | chemical drug | NA | NA | 3.0e-02 | FOS | NA |
| ethyl ether | NA | chemical reagent | NA | NA | 3.0e-02 | FOS | NA |
| rocuronium | NA | chemical drug | NA | NA | 3.0e-02 | CCND1 | NA |
| cycloserine | NA | chemical drug | NA | NA | 3.0e-02 | FOS | NA |
| natamycin | NA | chemical drug | NA | NA | 3.0e-02 | LCN2 | NA |
| tarenflurbil | NA | chemical drug | NA | NA | 3.0e-02 | CCND1 | NA |
| minodronate | NA | chemical drug | NA | NA | 3.0e-02 | CXCR4 | NA |
| oxodiperoxo(pyridine-2-carboxylate)vanadate(V) | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A | NA |
| NSC 644221 | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A | NA |
| devazepide | NA | chemical drug | NA | NA | 3.0e-02 | FOS | NA |
| ofloxacin | NA | chemical drug | NA | NA | 3.0e-02 | CDKN1A | NA |
| modafinil | NA | chemical drug | NA | NA | 3.0e-02 | FOS | NA |
| 10-decarbamoylmitomycin C | NA | chemical toxicant | NA | NA | 3.0e-02 | CDKN1A | NA |
| ethyl-3-trifluoromethylbenzyl-alpha-ketoglutarate | NA | chemical reagent | NA | NA | 3.0e-02 | SLC2A1 | NA |
| idronoxil | NA | chemical drug | NA | NA | 3.0e-02 | CDKN1A | NA |
| serpin peptide 16 | NA | biologic drug | NA | NA | 3.0e-02 | TLR4 | NA |
| SYUIQ-5 | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A | NA |
| potassium tetraperoxochromate | NA | chemical reagent | NA | NA | 3.0e-02 | TLR4 | NA |
| Ala-Tyr-Pro-Gly-Lys-Phe-NH2 | NA | chemical reagent | NA | NA | 3.0e-02 | FOS | NA |
| senktide | NA | chemical reagent | NA | NA | 3.0e-02 | FOS | NA |
| R-etodolac | NA | chemical drug | NA | NA | 3.0e-02 | CCND1 | NA |
| 3,7-dimethyl-1-propargylxanthine | NA | chemical reagent | NA | NA | 3.0e-02 | FOS | NA |
| 2-amino-3-phosphonopropionic acid | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | FOS | NA |
| ponasterone A | NA | chemical reagent | NA | NA | 3.0e-02 | CCND1 | NA |
| epiallopregnanolone | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | LGALS3 | NA |
| mir-142 | NA | microRNA | NA | NA | 3.0e-02 | AHR,CD93,GBP5 | NA |
| MAP2K3 | -1.40e-01 | kinase | NA | NA | 3.0e-02 | CDKN1A,MYH6,SGK1 | NA |
| RHO | -1.60e-01 | G-protein coupled receptor | NA | NA | 3.0e-02 | FOS,Mt1,SGK1 | NA |
| IKZF3 | -1.40e-01 | transcription regulator | NA | NA | 3.0e-02 | RNF213,SPSB1,TLR4 | NA |
| TREM2 | NA | transmembrane receptor | NA | NA | 3.0e-02 | FZD9,LGALS3,NFKBIA | NA |
| RUNX1-RUNX1T1 | NA | fusion gene/product | NA | NA | 3.0e-02 | ASPA,CDKN1A,ID2,ZBTB16 | NA |
| Wy 40905 | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A,FOS,PER1 | NA |
| PLAU | -2.70e-01 | peptidase | NA | NA | 3.0e-02 | CCND1,CCR5,SLC2A1 | NA |
| ZEB2 | -3.80e-01 | transcription regulator | NA | NA | 3.0e-02 | CCND1,CDKN1A,ID2 | NA |
| gemfibrozil | NA | chemical drug | NA | NA | 3.0e-02 | CCND1,EHHADH,NFKBIA | NA |
| trans-cinnamaldehyde | NA | chemical drug | NA | NA | 3.0e-02 | CDKN1A,NCF1 | NA |
| IFNL3 | NA | cytokine | NA | NA | 3.0e-02 | TLR2,TLR4 | NA |
| GRP | 5.00e-02 | growth factor | NA | NA | 3.0e-02 | CCND1,FOS | NA |
| ACTL6A | 2.70e-01 | other | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| SUB1 | 9.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CCND1,FOS | NA |
| NMU | 4.00e-01 | other | NA | NA | 3.0e-02 | IL1R2,Mt1 | NA |
| EPOR | 2.00e-02 | transmembrane receptor | NA | NA | 3.0e-02 | MERTK,SLC40A1 | NA |
| HOXA7 | NA | transcription regulator | NA | NA | 3.0e-02 | CD93,LY86 | NA |
| methylnitronitrosoguanidine | NA | chemical toxicant | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| dicarbethoxydihydrocollidine | NA | chemical toxicant | NA | NA | 3.0e-02 | SGK1,WNT7A | NA |
| hemozoin | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | CCR5,CXCR4 | NA |
| POU2AF1 | -7.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CCR5,CXCR4,GADD45G,LFNG | NA |
| Ap1 | NA | complex | NA | NA | 3.0e-02 | CCND1,CXCL12,FOS,NOTCH4,TLR4 | NA |
| MSTN | 3.30e-01 | growth factor | NA | NA | 3.0e-02 | CDKN1A,FOS,SLC2A1 | NA |
| KCNIP3 | 8.10e-01 | transcription regulator | NA | NA | 3.0e-02 | CCND1,CCR5,FOS | NA |
| NDRG1 | 3.10e-01 | kinase | NA | NA | 3.0e-02 | CCND1,ERBB3,FOS | NA |
| Ngf | NA | group | NA | NA | 3.0e-02 | CCND1,CDKN1A,FOS | NA |
| SUPT16H | -7.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CCND1,CDKN1A,ID2,TRIM72 | NA |
| JAK1 | 1.00e-02 | kinase | NA | NA | 3.0e-02 | CDKN1A,FOS,SFTPB | NA |
| ATM | -2.50e-01 | kinase | NA | NA | 3.0e-02 | CCND1,CDKN1A,GADD45G | NA |
| TBP | -1.00e-01 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,FOS,NFKBIA | NA |
| CHD4 | -2.10e-01 | enzyme | NA | NA | 3.0e-02 | ADORA1,CDKN1A,ID2 | NA |
| GC-GCR dimer | NA | complex | NA | NA | 3.0e-02 | IL1R2,NFKBIA | NA |
| choline fenofibrate | NA | chemical drug | NA | NA | 3.0e-02 | CXCL12,NFKBIA | NA |
| olaparib | NA | chemical drug | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| LUCAT1 | NA | other | NA | NA | 3.0e-02 | CDKN1A,ERBB3 | NA |
| RPSA | 3.40e-01 | translation regulator | NA | NA | 3.0e-02 | Ifi47,TLR4 | NA |
| SFRP4 | -9.00e-02 | transmembrane receptor | NA | NA | 3.0e-02 | CCND1,MYH6 | NA |
| MST1R | -2.30e-01 | kinase | NA | NA | 3.0e-02 | CCND1,FOS | NA |
| ferulic acid | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | CDKN1A,TLR4 | NA |
| fucoidin | NA | chemical drug | NA | NA | 3.0e-02 | CDKN1A,CXCL12 | NA |
| reactive oxygen species | NA | chemical toxicant | NA | NA | 3.0e-02 | CDKN1A,CXCR4,ERBB3,TLR2 | NA |
| G protein alpha i | NA | group | NA | NA | 3.0e-02 | FOS,GBP5,Irgm1 | NA |
| SPDEF | 4.70e-01 | transcription regulator | NA | NA | 3.0e-02 | CDH11,CDKN1A,COL13A1 | NA |
| E2F2 | -3.70e-01 | transcription regulator | NA | NA | 3.0e-02 | CCND1,CDKN1A,MCM10 | NA |
| anakinra | NA | biologic drug | NA | NA | 3.0e-02 | CXCL12,Slco1a4 | NA |
| MPT0B291 | NA | chemical reagent | NA | NA | 3.0e-02 | APEX2,MCM10 | NA |
| Stat5 dimer | NA | complex | NA | NA | 3.0e-02 | CCND1,TLR2 | NA |
| G-1 | NA | chemical reagent | NA | NA | 3.0e-02 | FOS,SLC2A1 | NA |
| RNF181 | 2.30e-01 | enzyme | NA | NA | 3.0e-02 | CXCL12,GRHL2 | NA |
| OXT | 3.40e-01 | other | NA | NA | 3.0e-02 | FOS,MYH6 | NA |
| MAPK11 | -6.00e-02 | kinase | NA | NA | 3.0e-02 | FOS,MYH6 | NA |
| SPHK2 | -4.00e-02 | kinase | NA | NA | 3.0e-02 | CDKN1A,MLXIPL | NA |
| VAV1 | -1.80e-01 | transcription regulator | NA | NA | 3.0e-02 | CCND1,FOS | NA |
| CTSB | 1.20e-01 | peptidase | NA | NA | 3.0e-02 | CCND1,CYBB | NA |
| MECOM | NA | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,GADD45G | NA |
| STS | 6.00e-02 | enzyme | NA | NA | 3.0e-02 | Mt1,PNPLA2 | NA |
| CFLAR | 1.00e-02 | other | NA | NA | 3.0e-02 | CDKN1A,FOS | NA |
| dithiothreitol | NA | chemical reagent | NA | NA | 3.0e-02 | CCND1,TLR2 | NA |
| fluvoxamine | NA | chemical drug | NA | NA | 3.0e-02 | CCR5,FOS | NA |
| crocidolite asbestos | NA | chemical toxicant | NA | NA | 3.0e-02 | CCND1,FOS | NA |
| arsenic | NA | chemical toxicant | NA | NA | 3.0e-02 | FOS,Mt1 | NA |
| corticosteroid | NA | chemical drug | NA | NA | 3.0e-02 | FKBP5,IL1R2,POSTN | NA |
| MEF2D | -1.00e-01 | transcription regulator | NA | NA | 3.0e-02 | CCND1,FOS,TGFB3 | NA |
| dinoprost | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | CCND1,FOS,ID2 | NA |
| IL11 | 1.50e-01 | cytokine | NA | NA | 3.0e-02 | FOS,POSTN,SFTPB | NA |
| NOTCH3 | -2.00e-01 | transcription regulator | NA | NA | 3.0e-02 | CDH11,CDKN1A,NRARP | NA |
| PIAS1 | 0.00e+00 | transcription regulator | NA | NA | 3.0e-02 | CCND1,CDKN1A,MYH6 | NA |
| ELK1 | 7.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,FOS,SLC2A1 | NA |
| Ppar | NA | group | NA | NA | 4.0e-02 | EHHADH,ELOVL7 | NA |
| grape seed extract | NA | chemical drug | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| Fc gamma receptor | NA | group | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| PCLAF | NA | other | NA | NA | 4.0e-02 | CDKN1A,GADD45G | NA |
| MYOG | NA | transcription regulator | NA | NA | 4.0e-02 | CDKN1A,FOS | NA |
| miR-26a-5p (and other miRNAs w/seed UCAAGUA) | NA | mature microRNA | NA | NA | 4.0e-02 | CDKN1A,CHORDC1 | NA |
| FOXF1 | -1.00e-01 | transcription regulator | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| KNG1 | NA | other | NA | NA | 4.0e-02 | CCND1,FOS | NA |
| WNT11 | -2.00e-02 | other | NA | NA | 4.0e-02 | MYH6,RSPO2 | NA |
| APEX1 | 3.10e-01 | enzyme | NA | NA | 4.0e-02 | CDKN1A,FOS | NA |
| UXT | 2.00e-01 | transcription regulator | NA | NA | 4.0e-02 | FKBP5,NFKBIA | NA |
| carvedilol | NA | chemical drug | NA | NA | 4.0e-02 | TLR4,TNFRSF11B | NA |
| urethane | NA | chemical toxicant | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| irbesartan | NA | chemical drug | NA | NA | 4.0e-02 | CYBB,FOS | NA |
| 2,4-dinitrophenol-ovalbumin conjugate | NA | chemical reagent | NA | NA | 4.0e-02 | FOS,PTCH1 | NA |
| letrozole | NA | chemical drug | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| ceramide | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | FOS,SFTPB | NA |
| TFAP2C | NA | transcription regulator | NA | NA | 4.0e-02 | CA12,CDKN1A,KITLG | NA |
| isotretinoin | NA | biologic drug | NA | NA | 4.0e-02 | CDKN1A,LCN2,TLR2 | NA |
| TFAP2A | -7.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CCND1,CDKN1A,KITLG,RPL6 | NA |
| Rp-8-Br-cGMPS | NA | chemical - kinase inhibitor | NA | NA | 4.0e-02 | FOS | NA |
| CGP 74514A | NA | chemical drug | NA | NA | 4.0e-02 | CCND1 | NA |
| 8-(3-chlorostyryl)caffeine | NA | chemical reagent | NA | NA | 4.0e-02 | FOS | NA |
| Ro 25-6760 | NA | chemical toxicant | NA | NA | 4.0e-02 | CDKN1A | NA |
| N4 | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1 | NA |
| 5-deoxy-rutaecarpine | NA | chemical reagent | NA | NA | 4.0e-02 | NFKBIA | NA |
| S-18886 | NA | chemical drug | NA | NA | 4.0e-02 | NCF1 | NA |
| PLD | NA | group | NA | NA | 4.0e-02 | PTP4A3 | NA |
| SNHG1 | NA | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| NU-7026 | NA | chemical drug | NA | NA | 4.0e-02 | FKBP5 | NA |
| tozasertib | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| 1-methyl-2-pyrrolidinone | NA | chemical drug | NA | NA | 4.0e-02 | FOS | NA |
| benoxaprofen | NA | chemical drug | NA | NA | 4.0e-02 | EHHADH | NA |
| Snhg6 | NA | other | NA | NA | 4.0e-02 | CCND1 | NA |
| WDR11 | -6.00e-02 | other | NA | NA | 4.0e-02 | PTCH1 | NA |
| DIRAS2 | -2.20e-01 | enzyme | NA | NA | 4.0e-02 | CCND1 | NA |
| ZFP42 | -3.80e-01 | transcription regulator | NA | NA | 4.0e-02 | CCND1 | NA |
| GNL3L | 3.00e-02 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| USE1 | 3.20e-01 | other | NA | NA | 4.0e-02 | CA6 | NA |
| PUM1 | -1.20e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| WAPL | -8.00e-02 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| SLC13A5 | 1.40e-01 | transporter | NA | NA | 4.0e-02 | CDKN1A | NA |
| NBR2 | NA | other | NA | NA | 4.0e-02 | SLC2A1 | NA |
| USP35 | 5.00e-02 | peptidase | NA | NA | 4.0e-02 | CCND1 | NA |
| endothelin receptor | NA | group | NA | NA | 4.0e-02 | FOS | NA |
| KCTD9 | -1.70e-01 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| Slfn1 | NA | enzyme | NA | NA | 4.0e-02 | CCND1 | NA |
| ORAI3 | -2.30e-01 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| 5730403I07Rik | NA | other | NA | NA | 4.0e-02 | CYBB | NA |
| DACT3 | 9.00e-02 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| K Channel | NA | complex | NA | NA | 4.0e-02 | CDKN1A | NA |
| Sapk | NA | group | NA | NA | 4.0e-02 | FOS | NA |
| tetrahydrocurcumin | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CDKN1A | NA |
| P-TEFb | NA | complex | NA | NA | 4.0e-02 | CDKN1A | NA |
| danusertib | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| Casein | NA | group | NA | NA | 4.0e-02 | ASPA | NA |
| ZNF467 | -1.50e-01 | transcription regulator | NA | NA | 4.0e-02 | FOS | NA |
| RAB11FIP3 | -1.40e-01 | other | NA | NA | 4.0e-02 | FOS | NA |
| TLCD3A | NA | other | NA | NA | 4.0e-02 | CCND1 | NA |
| ACTC1 | 9.00e-02 | enzyme | NA | NA | 4.0e-02 | CYBB | NA |
| CDC25B | -3.00e-01 | phosphatase | NA | NA | 4.0e-02 | CCND1 | NA |
| ADRA2B | -1.80e-01 | G-protein coupled receptor | NA | NA | 4.0e-02 | CCND1 | NA |
| PTPRF | 2.00e-02 | phosphatase | NA | NA | 4.0e-02 | CCND1 | NA |
| CELA2A | NA | peptidase | NA | NA | 4.0e-02 | CDKN1A | NA |
| SUFU | -4.70e-01 | transcription regulator | NA | NA | 4.0e-02 | PTCH1 | NA |
| ANXA5 | -7.00e-02 | transporter | NA | NA | 4.0e-02 | CDKN1A | NA |
| SPTBN1 | -1.80e-01 | other | NA | NA | 4.0e-02 | FOS | NA |
| NMB | 3.20e-01 | other | NA | NA | 4.0e-02 | FOS | NA |
| GRPR | -7.00e-02 | G-protein coupled receptor | NA | NA | 4.0e-02 | CDKN1A | NA |
| ARID1B | -5.00e-02 | transcription regulator | NA | NA | 4.0e-02 | FOS | NA |
| CUL4A | 1.20e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| miR-515-5p (and other miRNAs w/seed UCUCCAA) | NA | mature microRNA | NA | NA | 4.0e-02 | PIK3C2B | NA |
| mir-136 | NA | microRNA | NA | NA | 4.0e-02 | CXCL12 | NA |
| mir-138 | NA | microRNA | NA | NA | 4.0e-02 | LCN2 | NA |
| miR-718 (miRNAs w/seed UUCCGCC) | NA | mature microRNA | NA | NA | 4.0e-02 | TLR4 | NA |
| TOPORS | -1.70e-01 | enzyme | NA | NA | 4.0e-02 | CDKN1A | NA |
| PPP1R3C | -2.00e-01 | phosphatase | NA | NA | 4.0e-02 | SLC2A1 | NA |
| SYNM | -1.00e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| HAS3 | -4.50e-01 | enzyme | NA | NA | 4.0e-02 | CDKN1A | NA |
| TOP3A | -2.40e-01 | enzyme | NA | NA | 4.0e-02 | CDKN1A | NA |
| KLF16 | NA | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| GCLC | 1.20e-01 | enzyme | NA | NA | 4.0e-02 | FOS | NA |
| BOP1 | 1.00e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| GALR1 | -6.00e-02 | G-protein coupled receptor | NA | NA | 4.0e-02 | CCND1 | NA |
| anatabine | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | IL1R2 | NA |
| ABCC9 | -2.00e-01 | ion channel | NA | NA | 4.0e-02 | SLC2A1 | NA |
| DLL3 | -1.70e-01 | other | NA | NA | 4.0e-02 | LFNG | NA |
| CLDN5 | 5.00e-02 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| UBTF | -1.80e-01 | transcription regulator | NA | NA | 4.0e-02 | CCND1 | NA |
| CTNNAL1 | -5.00e-02 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| SNRK | -2.50e-01 | kinase | NA | NA | 4.0e-02 | CCND1 | NA |
| PFKFB1 | 0.00e+00 | kinase | NA | NA | 4.0e-02 | MYH6 | NA |
| WARS1 | NA | enzyme | NA | NA | 4.0e-02 | NFKBIA | NA |
| GP1BA | 1.40e-01 | transmembrane receptor | NA | NA | 4.0e-02 | AURKB | NA |
| ELOA | 3.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| S3I-1757 | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1 | NA |
| GLUD1 | 1.30e-01 | enzyme | NA | NA | 4.0e-02 | SLC2A1 | NA |
| Hyaluronidase | NA | biologic drug | NA | NA | 4.0e-02 | ADAMTS4 | NA |
| COL1A2 | NA | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| LOC101927189 | NA | other | NA | NA | 4.0e-02 | CYBB | NA |
| SLC9A3R2 | -1.50e-01 | transporter | NA | NA | 4.0e-02 | CCND1 | NA |
| RING1 | 1.10e-01 | transcription regulator | NA | NA | 4.0e-02 | FOS | NA |
| PARP10 | -1.50e-01 | enzyme | NA | NA | 4.0e-02 | CCND1 | NA |
| ACP1 | NA | phosphatase | NA | NA | 4.0e-02 | FOS | NA |
| ARF1 | 3.20e-01 | enzyme | NA | NA | 4.0e-02 | CCND1 | NA |
| TBPL1 | -5.00e-02 | transcription regulator | NA | NA | 4.0e-02 | FOS | NA |
| NBN | -3.00e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| NOC2L | -6.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| ceralasertib | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| ZC3H13 | -5.00e-02 | other | NA | NA | 4.0e-02 | SLC2A1 | NA |
| RRM2B | -3.00e-02 | enzyme | NA | NA | 4.0e-02 | CDKN1A | NA |
| HIF1A-AS3 | NA | other | NA | NA | 4.0e-02 | SLC2A1 | NA |
| azurin 50-77 | NA | biologic drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| GR-MD-02 | NA | chemical drug | NA | NA | 4.0e-02 | LGALS3 | NA |
| farnesyltransferase inhibitor | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| LY5 | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1 | NA |
| p38 MAP kinase inhibitor | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| benfur | NA | chemical reagent | NA | NA | 4.0e-02 | CDKN1A | NA |
| apicularen A | NA | chemical reagent | NA | NA | 4.0e-02 | NFKBIA | NA |
| iopanoic acid | NA | chemical drug | NA | NA | 4.0e-02 | PNPLA2 | NA |
| acetoacetic acid | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CCND1 | NA |
| phenformin | NA | chemical drug | NA | NA | 4.0e-02 | SLC2A1 | NA |
| ketanserin | NA | chemical drug | NA | NA | 4.0e-02 | FOS | NA |
| tirapazamine | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| hoechst 33342 | NA | chemical reagent | NA | NA | 4.0e-02 | FOS | NA |
| tipifarnib | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| KP-SD-1 | NA | chemical drug | NA | NA | 4.0e-02 | CCND1 | NA |
| arzoxifene | NA | chemical drug | NA | NA | 4.0e-02 | TGFB3 | NA |
| polymethyl methacrylate | NA | chemical reagent | NA | NA | 4.0e-02 | TNFRSF11A | NA |
| ibotenic acid | NA | chemical toxicant | NA | NA | 4.0e-02 | FOS | NA |
| phenylhydrazine | NA | chemical toxicant | NA | NA | 4.0e-02 | LCN2 | NA |
| glabridin | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | FOS | NA |
| centrinone | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| tramadol | NA | chemical drug | NA | NA | 4.0e-02 | FOS | NA |
| chloral hydrate | NA | chemical drug | NA | NA | 4.0e-02 | PTCH1 | NA |
| nabumetone | NA | chemical drug | NA | NA | 4.0e-02 | MYH6 | NA |
| cromakalim | NA | chemical drug | NA | NA | 4.0e-02 | FOS | NA |
| betamethasone valerate | NA | chemical drug | NA | NA | 4.0e-02 | CCND1 | NA |
| cadmium sulfate | NA | chemical toxicant | NA | NA | 4.0e-02 | Mt1 | NA |
| 1,1-diethyl-2-hydroxy-2-nitrosohydrazine | NA | chemical toxicant | NA | NA | 4.0e-02 | NFKBIA | NA |
| SMAD1/5/9 | NA | group | NA | NA | 4.0e-02 | CDKN1A | NA |
| nexinhib20 | NA | chemical reagent | NA | NA | 4.0e-02 | CYBB | NA |
| 6-cyclopropyl-1-(4-fluorophenyl)-3-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxylic acid | NA | chemical reagent | NA | NA | 4.0e-02 | PEX11A | NA |
| atosibanum | NA | biologic drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| elcatonin | NA | biologic drug | NA | NA | 4.0e-02 | TNFRSF11B | NA |
| C29 | NA | chemical reagent | NA | NA | 4.0e-02 | TNFRSF11A | NA |
| yohimbine | NA | chemical drug | NA | NA | 4.0e-02 | FOS | NA |
| succinylacetone | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CYBB | NA |
| fenclonine | NA | chemical drug | NA | NA | 4.0e-02 | PTCH1 | NA |
| iodixanol | NA | chemical drug | NA | NA | 4.0e-02 | LCN2 | NA |
| thymeleatoxin | NA | chemical toxicant | NA | NA | 4.0e-02 | CDKN1A | NA |
| steroid hormone | NA | chemical - other | NA | NA | 4.0e-02 | CXCR4 | NA |
| FGFR2 | -5.00e-02 | kinase | NA | NA | 4.0e-02 | CCND1,CDH11,CDKN1A,ID2 | NA |
| ATP-gamma-S | NA | chemical reagent | NA | NA | 4.0e-02 | CCR5,CXCR4,IL1R2 | NA |
| FGF21 | -8.00e-02 | growth factor | NA | NA | 4.0e-02 | CCND1,FOS,SLC2A1 | NA |
| PRKCE | 0.00e+00 | kinase | NA | NA | 4.0e-02 | CCND1,CDKN1A,FOS | NA |
| minocycline | NA | chemical drug | NA | NA | 4.0e-02 | CYBB,FOS,TLR4 | NA |
| fenretinide | NA | chemical drug | NA | NA | 4.0e-02 | ACER2,CCND1,NFKBIA | NA |
| folic acid | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CDKN1A,CYBB,LGALS3 | NA |
| prostaglandin J2 | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| CARD9 | -2.90e-01 | other | NA | NA | 4.0e-02 | CCR5,TLR2 | NA |
| BMS-690514 | NA | chemical drug | NA | NA | 4.0e-02 | CCND1,MCM10 | NA |
| Cdk | NA | group | NA | NA | 4.0e-02 | GADD45G,PLEKHF1 | NA |
| trametinib | NA | chemical drug | NA | NA | 4.0e-02 | MYBPH,ROR1 | NA |
| PCSK9 | 7.00e-02 | peptidase | NA | NA | 4.0e-02 | CDKN1A,TLR2 | NA |
| HAND1 | -2.00e-02 | transcription regulator | NA | NA | 4.0e-02 | DBI,NOTCH4 | NA |
| ARHGAP31 | 2.40e-01 | other | NA | NA | 4.0e-02 | ID2,TGFB3 | NA |
| ICMT | -2.30e-01 | enzyme | NA | NA | 4.0e-02 | CDKN1A,CRYAB | NA |
| TRPV4 | 1.40e-01 | ion channel | NA | NA | 4.0e-02 | FOS,TLR2 | NA |
| DAXX | -7.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| EGLN3 | -3.00e-02 | enzyme | NA | NA | 4.0e-02 | SLC2A1,TNFRSF11B | NA |
| TAB1 | 1.20e-01 | enzyme | NA | NA | 4.0e-02 | CDKN1A,NFKBIA | NA |
| hymecromone | NA | chemical drug | NA | NA | 4.0e-02 | ADAMTS4,CXCR4 | NA |
| TAS4464 | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A,FOS | NA |
| SUZ12 | -1.60e-01 | enzyme | NA | NA | 4.0e-02 | INSIG1,LGALS3,POU2F3,TNFRSF11B | NA |
| YBX1 | 1.70e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A,FOS,LGALS3,USP2 | NA |
| nifedipine | NA | chemical drug | NA | NA | 4.0e-02 | FOS,POSTN,SGK1 | NA |
| rottlerin | NA | chemical drug | NA | NA | 4.0e-02 | CCND1,CDKN1A,FKBP5 | NA |
| heparin | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CCND1,FOS,SLC2A1 | NA |
| RETNLB | NA | other | NA | NA | 4.0e-02 | CCR5,MAP3K6,TLR2 | NA |
| nelfinavir | NA | chemical drug | NA | NA | 4.0e-02 | CA6,PLIN4,TNFRSF11B | NA |
| N-Ac-Leu-Leu-norleucinal | NA | chemical - protease inhibitor | NA | NA | 4.0e-02 | CCND1,CDKN1A,NFKBIA | NA |
| FHIT | NA | enzyme | NA | NA | 4.0e-02 | CDKN1A,TGFB3 | NA |
| deoxycorticosterone acetate/potassium chloride/sodium chloride | NA | chemical reagent | NA | NA | 4.0e-02 | CCR5,CYBB | NA |
| 4-(2-aminoethyl)benzenesulfonylfluoride | NA | chemical - protease inhibitor | NA | NA | 4.0e-02 | CDKN1A,ENPP3 | NA |
| Gsk3 | NA | group | NA | NA | 4.0e-02 | CCND1,FOS,MYH6 | NA |
| NTRK2 | 9.00e-02 | kinase | NA | NA | 4.0e-02 | CCND1,CDKN1A,FOS | NA |
| MAP3K14 | -1.00e-01 | kinase | NA | NA | 4.0e-02 | GBP5,IL1R2,NFKBIA | NA |
| BMAL1 | NA | transcription regulator | NA | NA | 4.0e-02 | HCRTR2,MLXIPL,PER1 | NA |
| ZBTB17 | 1.70e-01 | transcription regulator | NA | NA | 4.0e-02 | AURKB,CCND1,CDKN1A | NA |
| entinostat | NA | chemical drug | NA | NA | 4.0e-02 | CCND1,CDKN1A,ERBB3 | NA |
| SOX17 | 2.00e-01 | transcription regulator | NA | NA | 4.0e-02 | CCND1,FOS | NA |
| ZC3H12C | -1.20e-01 | other | NA | NA | 4.0e-02 | CCR5,GPR34 | NA |
| leucine | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CDKN1A,FOS | NA |
| HOXC8 | 0.00e+00 | transcription regulator | NA | NA | 4.0e-02 | CDH11,IL1R2 | NA |
| ZBTB7A | -2.20e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A,FOS | NA |
| PSMD10 | 1.00e-01 | transcription regulator | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| PHB1 | NA | transcription regulator | NA | NA | 4.0e-02 | CCND1,NFKBIA | NA |
| PRLR | -1.20e-01 | transmembrane receptor | NA | NA | 4.0e-02 | CDKN1A,SLC34A2 | NA |
| IL17RA | 3.80e-01 | transmembrane receptor | NA | NA | 4.0e-02 | CSF3R,CXCL12 | NA |
| NF1 | -1.70e-01 | other | NA | NA | 4.0e-02 | CCND1,RPL10A | NA |
| PAK1 | 1.00e-01 | kinase | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| green tea polyphenol | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A,FOS | NA |
| BRAF | -1.20e-01 | kinase | NA | NA | 4.0e-02 | CCND1,CDKN1A,ERBB3,POU3F2,SLC26A2,TNFRSF11B | NA |
| fluoride | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CA6,FOS,MYH6 | NA |
| Rb | NA | group | NA | NA | 4.0e-02 | AURKB,CCND1,CDKN1A | NA |
| IFN alpha/beta | NA | group | NA | NA | 4.0e-02 | Irgm1,RNF213,TLR2 | NA |
| dorsomorphin | NA | chemical - kinase inhibitor | NA | NA | 4.0e-02 | ID2,PNPLA2,POSTN | NA |
| TPH1 | 1.40e-01 | enzyme | NA | NA | 4.0e-02 | AEN,CCR5,IL1R2 | NA |
| zinc | NA | chemical drug | NA | NA | 4.0e-02 | CCND1,Mt1,NFKBIA | NA |
| PNPLA2 | 1.24e+00 | enzyme | NA | NA | 4.0e-02 | PLIN5,PNPLA2,SLC2A1 | NA |
| JUND | 3.00e-01 | transcription regulator | NA | NA | 4.0e-02 | C1QB,CCND1,CYBB | NA |
| Ap2 | NA | group | NA | NA | 4.0e-02 | ERBB3,TGFB3 | NA |
| asoprisnil | NA | chemical drug | NA | NA | 4.0e-02 | SGK1,TGFB3 | NA |
| CRNDE | NA | other | NA | NA | 4.0e-02 | CDKN1A,PGF | NA |
| TFDP1 | 9.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| DDX3X | NA | enzyme | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| PBX1 | -2.20e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A,CYBB | NA |
| CDC42 | NA | enzyme | NA | NA | 4.0e-02 | CCND1,FOS | NA |
| mercuric chloride | NA | chemical toxicant | NA | NA | 4.0e-02 | CDKN1A,Mt1 | NA |
| verteporfin | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A,NFKBIA | NA |
| vinblastine | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A,FOS | NA |
| TFAM | 4.00e-02 | transcription regulator | NA | NA | 4.0e-02 | PLCB2,SLC2A1,ZBTB16 | NA |
| CF102 | NA | chemical drug | NA | NA | 5.0e-02 | CYBB | NA |
| p38 Sapk | NA | group | NA | NA | 5.0e-02 | CCND1 | NA |
| teniposide | NA | chemical drug | NA | NA | 5.0e-02 | CDKN1A | NA |
| ILX-23-7553 | NA | chemical drug | NA | NA | 5.0e-02 | CCND1 | NA |
| estradiol 17beta-cypionate | NA | chemical drug | NA | NA | 5.0e-02 | PER1 | NA |
| fludrocortisone | NA | chemical drug | NA | NA | 5.0e-02 | CXCR4 | NA |
| TPPP2 | 6.00e-02 | other | NA | NA | 5.0e-02 | CDKN1A | NA |
| sargramostim | NA | biologic drug | NA | NA | 5.0e-02 | CYBB | NA |
| SGI-1027 | NA | chemical reagent | NA | NA | 5.0e-02 | USP2 | NA |
| ADRA1 | NA | group | NA | NA | 5.0e-02 | FOS | NA |
| saxagliptin | NA | chemical drug | NA | NA | 5.0e-02 | TLR4 | NA |
| Alp | NA | group | NA | NA | 5.0e-02 | LCN2 | NA |
| Ctnna | NA | group | NA | NA | 5.0e-02 | CXCR4 | NA |
| Stat dimer | NA | complex | NA | NA | 5.0e-02 | FOS | NA |
| Dexamethasone-GR | NA | complex | NA | NA | 5.0e-02 | SGK1 | NA |
| ZBED1 | NA | enzyme | NA | NA | 5.0e-02 | RPL10A | NA |
| DRD3 | -7.00e-02 | G-protein coupled receptor | NA | NA | 5.0e-02 | FOS | NA |
| Jun-ATF2 | NA | complex | NA | NA | 5.0e-02 | CCND1 | NA |
| NLR | NA | group | NA | NA | 5.0e-02 | LCN2 | NA |
| DESI2 | 0.00e+00 | enzyme | NA | NA | 5.0e-02 | CDKN1A | NA |
| DACT1 | -1.00e-01 | other | NA | NA | 5.0e-02 | CCND1 | NA |
| MARCHF3 | NA | other | NA | NA | 5.0e-02 | NFKBIA | NA |
| TRIM58 | 1.20e-01 | enzyme | NA | NA | 5.0e-02 | TLR2 | NA |
| BUD23 | NA | enzyme | NA | NA | 5.0e-02 | FKBP5 | NA |
| ZMIZ2 | -6.00e-02 | transcription regulator | NA | NA | 5.0e-02 | CCND1 | NA |
| PYHIN1 | NA | other | NA | NA | 5.0e-02 | CDKN1A | NA |
| CUZD1 | 0.00e+00 | other | NA | NA | 5.0e-02 | ID2 | NA |
| YIPF6 | -2.00e-02 | other | NA | NA | 5.0e-02 | PNPLA2 | NA |
| DRD1/5 | NA | group | NA | NA | 5.0e-02 | FOS | NA |
| sGC | NA | complex | NA | NA | 5.0e-02 | FOS | NA |
| SLU7 | 1.10e-01 | enzyme | NA | NA | 5.0e-02 | CDKN1A | NA |
| CDH16 | 3.00e-02 | enzyme | NA | NA | 5.0e-02 | CCND1 | NA |
| CREB3L4 | -5.00e-02 | transcription regulator | NA | NA | 5.0e-02 | ID2 | NA |
| RPE65 | 8.40e-01 | enzyme | NA | NA | 5.0e-02 | FOS | NA |
| CDCA2 | -1.20e-01 | other | NA | NA | 5.0e-02 | CDKN1A | NA |
| TH1 Cytokine | NA | group | NA | NA | 5.0e-02 | CCR5 | NA |
| PX 478 | NA | chemical drug | NA | NA | 5.0e-02 | SLC2A1 | NA |
| Cathepsin | NA | group | NA | NA | 5.0e-02 | CCND1 | NA |
| 7S NGF | NA | complex | NA | NA | 5.0e-02 | FOS | NA |
| EIF3I | 2.20e-01 | translation regulator | NA | NA | 5.0e-02 | CCND1 | NA |
| MIR3936HG | NA | other | NA | NA | 5.0e-02 | CCND1 | NA |
| omipalisib | NA | chemical drug | NA | NA | 5.0e-02 | AURKB | NA |
| NUP98 | -1.60e-01 | enzyme | NA | NA | 5.0e-02 | CDKN1A | NA |
| UBB | NA | enzyme | NA | NA | 5.0e-02 | NFKBIA | NA |
| MCF2 | -1.20e-01 | other | NA | NA | 5.0e-02 | CCND1 | NA |
| TYMS | -5.00e-02 | enzyme | NA | NA | 5.0e-02 | CDKN1A | NA |
| RNF34 | 2.20e-01 | enzyme | NA | NA | 5.0e-02 | CDKN1A | NA |
| miR-570-3p (miRNAs w/seed GAAAACA) | NA | mature microRNA | NA | NA | 5.0e-02 | CDKN1A | NA |
| miR-466m-3p (and other miRNAs w/seed ACAUACA) | NA | mature microRNA | NA | NA | 5.0e-02 | Podxl | NA |
| miR-370-3p (and other miRNAs w/seed CCUGCUG) | NA | mature microRNA | NA | NA | 5.0e-02 | WNT7A | NA |
| MIR3662 | NA | microRNA | NA | NA | 5.0e-02 | CCND1 | NA |
| mir-383 | NA | microRNA | NA | NA | 5.0e-02 | GADD45G | NA |
| PPP1R13B | 3.40e-01 | phosphatase | NA | NA | 5.0e-02 | CDKN1A | NA |
| KCND2 | NA | ion channel | NA | NA | 5.0e-02 | KCNIP3 | NA |
| RHOH | 2.40e-01 | enzyme | NA | NA | 5.0e-02 | CDKN1A | NA |
| UTS2 | NA | other | NA | NA | 5.0e-02 | FOS | NA |
| CDR2 | -1.80e-01 | other | NA | NA | 5.0e-02 | SLC2A1 | NA |
| RBM14 | -5.70e-01 | transcription regulator | NA | NA | 5.0e-02 | CCND1 | NA |
| SEPTIN9 | NA | enzyme | NA | NA | 5.0e-02 | CCND1 | NA |
| PENK | -1.00e-02 | other | NA | NA | 5.0e-02 | FOS | NA |
| PSAP | 1.30e-01 | other | NA | NA | 5.0e-02 | CCND1 | NA |
| ALDH3A1 | -2.60e-01 | enzyme | NA | NA | 5.0e-02 | CDKN1A | NA |
| KCTD11 | -1.60e-01 | other | NA | NA | 5.0e-02 | PTCH1 | NA |
| PORCN | 2.30e-01 | enzyme | NA | NA | 5.0e-02 | CCND1 | NA |
| KIDINS220 | -7.00e-02 | transcription regulator | NA | NA | 5.0e-02 | FOS | NA |
| ARLNC1 | NA | other | NA | NA | 5.0e-02 | FKBP5 | NA |
| RPS3 | 5.50e-01 | enzyme | NA | NA | 5.0e-02 | NFKBIA | NA |
| BCAR3 | 2.30e-01 | other | NA | NA | 5.0e-02 | CCND1 | NA |
| CEL | -2.20e-01 | enzyme | NA | NA | 5.0e-02 | CCND1 | NA |
| HEPH | 8.00e-02 | transporter | NA | NA | 5.0e-02 | SLC40A1 | NA |
| SH2B2 | -2.30e-01 | other | NA | NA | 5.0e-02 | FOS | NA |
| TACC3 | 2.40e-01 | other | NA | NA | 5.0e-02 | CDKN1A | NA |
| PRMT2 | 8.00e-02 | enzyme | NA | NA | 5.0e-02 | CCND1 | NA |
| ARHGEF2 | -1.40e-01 | other | NA | NA | 5.0e-02 | CCND1 | NA |
| VCAM1 | -1.00e-01 | transmembrane receptor | NA | NA | 5.0e-02 | CCND1 | NA |
| CDC27 | -2.00e-01 | other | NA | NA | 5.0e-02 | CCND1 | NA |
| PLK3 | 1.60e-01 | kinase | NA | NA | 5.0e-02 | CDKN1A | NA |
| copanlisib | NA | chemical drug | NA | NA | 5.0e-02 | AURKB | NA |
| GNL2 | 2.20e-01 | enzyme | NA | NA | 5.0e-02 | CDKN1A | NA |
| N-lauroyl-L-phenylalanine | NA | chemical reagent | NA | NA | 5.0e-02 | GADD45G | NA |
| RSU1 | -8.00e-02 | other | NA | NA | 5.0e-02 | CDKN1A | NA |
| Nrg1 | NA | growth factor | NA | NA | 5.0e-02 | FOS | NA |
| Cox5b/Gm34962 | NA | other | NA | NA | 5.0e-02 | POSTN | NA |
| KRT10 | NA | other | NA | NA | 5.0e-02 | CCND1 | NA |
| Muc1 | 1.00e-02 | transmembrane receptor | NA | NA | 5.0e-02 | CCND1 | NA |
| TWSG1 | -1.60e-01 | other | NA | NA | 5.0e-02 | ID2 | NA |
| GCLM | -1.90e-01 | enzyme | NA | NA | 5.0e-02 | FOS | NA |
| GYS2 | 4.00e-02 | enzyme | NA | NA | 5.0e-02 | MLXIPL | NA |
| CLDN2 | -1.00e-01 | other | NA | NA | 5.0e-02 | CCND1 | NA |
| VAS-2870 | NA | chemical reagent | NA | NA | 5.0e-02 | CDKN1A | NA |
| MI-773 | NA | chemical drug | NA | NA | 5.0e-02 | CDKN1A | NA |
| CMP5 | NA | chemical reagent | NA | NA | 5.0e-02 | CCND1 | NA |
| scoparone | NA | chemical - endogenous non-mammalian | NA | NA | 5.0e-02 | CCND1 | NA |
| fluticasone | NA | chemical drug | NA | NA | 5.0e-02 | TLR4 | NA |
| gabapentin | NA | chemical drug | NA | NA | 5.0e-02 | FOS | NA |
| methylamine | NA | chemical - endogenous mammalian | NA | NA | 5.0e-02 | SLC2A1 | NA |
| phenylmethylsulfonyl fluoride | NA | chemical - protease inhibitor | NA | NA | 5.0e-02 | TLR4 | NA |
| SQ 29548 | NA | chemical reagent | NA | NA | 5.0e-02 | NR0B1 | NA |
| CP 96345 | NA | chemical drug | NA | NA | 5.0e-02 | CCR5 | NA |
| benidipine | NA | chemical drug | NA | NA | 5.0e-02 | CDKN1A | NA |
| AM 630 | NA | chemical reagent | NA | NA | 5.0e-02 | TNFRSF11A | NA |
| lindane | NA | chemical drug | NA | NA | 5.0e-02 | FOS | NA |
| vinyl carbamate | NA | chemical toxicant | NA | NA | 5.0e-02 | CDKN1A | NA |
| plevitrexed | NA | chemical drug | NA | NA | 5.0e-02 | CDKN1A | NA |
| fenoldopam | NA | chemical drug | NA | NA | 5.0e-02 | CYBB | NA |
| etidronic acid | NA | chemical drug | NA | NA | 5.0e-02 | FOS | NA |
| alizarin | NA | chemical toxicant | NA | NA | 5.0e-02 | CCND1 | NA |
| ethyl protocatechuate | NA | chemical reagent | NA | NA | 5.0e-02 | CDKN1A | NA |
| vanadyl sulfate | NA | chemical reagent | NA | NA | 5.0e-02 | IL1R2 | NA |
| sodium chlorate | NA | chemical reagent | NA | NA | 5.0e-02 | PTCH1 | NA |
| FT671 | NA | chemical - protease inhibitor | NA | NA | 5.0e-02 | CDKN1A | NA |
| dexfenfluramine | NA | chemical drug | NA | NA | 5.0e-02 | FOS | NA |
| geraniol | NA | chemical - endogenous non-mammalian | NA | NA | 5.0e-02 | CDKN1A | NA |
| cannabinoid | NA | chemical drug | NA | NA | 5.0e-02 | CXCR4 | NA |
| phloroglucinol | NA | chemical drug | NA | NA | 5.0e-02 | FOS | NA |
| 9-hydroxyoctadecadienoic acid | NA | chemical - endogenous mammalian | NA | NA | 5.0e-02 | SFTPB | NA |
| 5-hydroxydecanoic acid | NA | chemical - endogenous mammalian | NA | NA | 5.0e-02 | FOS | NA |
| 5-hydroxytryptophan | NA | chemical - endogenous mammalian | NA | NA | 5.0e-02 | FOS | NA |
| Cr6+ | NA | chemical reagent | NA | NA | 5.0e-02 | Mt1 | NA |
| GAST | 2.80e-01 | other | NA | NA | 5.0e-02 | CCND1,FOS,NFKBIA | NA |
| LYN | -2.10e-01 | kinase | NA | NA | 5.0e-02 | CDKN1A,NFKBIA,TGFB3 | NA |
| RPTOR | -1.00e-02 | other | NA | NA | 5.0e-02 | CCND1,CXCL12,Ifi47,SLC2A1 | NA |
| RNASEL | 6.00e-02 | enzyme | NA | NA | 5.0e-02 | CDKN1A,FZD10 | NA |
| DLL1 | -4.50e-01 | enzyme | NA | NA | 5.0e-02 | CDKN1A,LFNG | NA |
| SUMO1 | 7.00e-02 | enzyme | NA | NA | 5.0e-02 | CCND1,MYH6 | NA |
| IL20 | -4.00e-02 | cytokine | NA | NA | 5.0e-02 | TLR2,TNFRSF11A | NA |
| PRKCZ | -8.00e-02 | kinase | NA | NA | 5.0e-02 | CCND1,NFKBIA | NA |
| PRKCQ | -4.00e-02 | kinase | NA | NA | 5.0e-02 | CCND1,CDKN1A | NA |
| GTF2B | 2.80e-01 | transcription regulator | NA | NA | 5.0e-02 | CDKN1A,NFKBIA | NA |
| PRKAR1A | 7.00e-02 | kinase | NA | NA | 5.0e-02 | CCND1,ERBB3 | NA |
| PTCH1 | -1.09e+00 | transmembrane receptor | NA | NA | 5.0e-02 | CCND1,PTCH1 | NA |
| FOSB | 1.50e-01 | transcription regulator | NA | NA | 5.0e-02 | CCND1,FOS | NA |
| AS1842856 | NA | chemical reagent | NA | NA | 5.0e-02 | CDKN1A,TLR4 | NA |
| nafenopin | NA | chemical drug | NA | NA | 5.0e-02 | CCND1,SGK1 | NA |
| exenatide | NA | biologic drug | NA | NA | 5.0e-02 | FOS,PER1 | NA |
| ATG5 | NA | other | NA | NA | 5.0e-02 | EVA1A,SLC2A1,SLC40A1 | NA |
| IFNL1 | NA | cytokine | NA | NA | 5.0e-02 | GBP5,LAMP3,TLR2 | NA |
| HDAC4 | 6.00e-02 | transcription regulator | NA | NA | 5.0e-02 | CCND1,CDKN1A,FOS,SLC2A1 | NA |
| STAT | NA | group | NA | NA | 5.0e-02 | CDKN1A,FOS | NA |
| KDM2B | -1.70e-01 | enzyme | NA | NA | 5.0e-02 | CDKN1A,FOS | NA |
| GNRH | NA | group | NA | NA | 5.0e-02 | FOS,SGK1 | NA |
| PRDM16 | -2.20e-01 | transcription regulator | NA | NA | 5.0e-02 | CDKN1A,GADD45G | NA |
| deferasirox | NA | chemical drug | NA | NA | 5.0e-02 | FOS,RGS1 | NA |
| CTF1 | -1.00e-01 | cytokine | NA | NA | 5.0e-02 | FOS,PNPLA2 | NA |
| ISLR | -1.60e-01 | other | NA | NA | 5.0e-02 | CIART,FOS | NA |
| GDF9 | -9.00e-02 | growth factor | NA | NA | 5.0e-02 | ID2,KITLG | NA |
| SLC16A2 | -3.00e-02 | transporter | NA | NA | 5.0e-02 | RBM3,SLCO1C1 | NA |
| acetylcholine | NA | chemical - endogenous mammalian | NA | NA | 5.0e-02 | FOS,TNFRSF11B | NA |
| SBDS | 2.50e-01 | other | NA | NA | 5.0e-02 | ERBB3,FOS,TERF2IP | NA |
| CDH1 | -3.00e-01 | other | NA | NA | 5.0e-02 | CCND1,ERBB3,LCN2 | NA |
| SMO | -6.00e-02 | G-protein coupled receptor | NA | NA | 5.0e-02 | CCND1,PTCH1,TGFB3 | NA |
| FADD | 4.00e-02 | other | NA | NA | 5.0e-02 | CDKN1A,CXCR4,FOS | NA |
| OLFM4-RET | NA | fusion gene/product | NA | NA | 5.0e-02 | CYTH4,FOS,SERPINB10 | NA |
| NEDD9 | 3.70e-01 | other | NA | NA | 5.0e-02 | FOS,Podxl,SLC2A1 | NA |
| haloperidol | NA | chemical drug | NA | NA | 5.0e-02 | FOS,PER1,Slco1a4 | NA |
HT %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S9. Ingenuity upstream regulators predicted to have similar activatory or inhibitory effect to ozone in HT - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))read_excel("../input_files/Upstream/Adrenal_upstream analysis.xls") %>% row_to_names(row_number=1) -> Adrenal## New names:
## • `` -> `...2`
## • `` -> `...3`
## • `` -> `...4`
## • `` -> `...5`
## • `` -> `...6`
## • `` -> `...7`
## • `` -> `...8`as.numeric(Adrenal$`Activation z-score`) -> Adrenal$`Activation z-score`
Adrenal <- Adrenal[order(-Adrenal$`Activation z-score`),]
as.numeric(Adrenal$`Expr Log Ratio`) -> Adrenal$`Expr Log Ratio`
as.numeric(Adrenal$`p-value of overlap`) -> Adrenal$`p-value of overlap`
Adrenal %>%
mutate(
`Expr Log Ratio`=format(round(`Expr Log Ratio`,2),nsmall=2,scientific=TRUE),
`Activation z-score`=format(round(`Activation z-score`,2),nsmall=2,scientific=TRUE),
`p-value of overlap`=format(round(`p-value of overlap`,2),nsmall=2,scientific=TRUE)) %>%
kable(caption = "Supplementary Table S8. Ingenuity upstream regulators predicted to have similar activatory or inhibitory effect to ozone in Adrenal", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(1:8,bold=ifelse(is.na(Adrenal$`Predicted Activation State`),F,T),color= ifelse(is.na(Adrenal$`Predicted Activation State`),"gray",ifelse(Adrenal$`Predicted Activation State` == "Inhibited","#40004B","#00441B"))) %>%
scroll_box(width = "1200px", height = "500px")| Upstream Regulator | Expr Log Ratio | Molecule Type | Predicted Activation State | Activation z-score | p-value of overlap | Target Molecules in Dataset | Mechanistic Network |
|---|---|---|---|---|---|---|---|
| NUPR1 | 6.10e-01 | transcription regulator | Activated | 5.13e+00 | 0.0e+00 | ABL2,ACTR3B,ALOXE3,ANGEL1,ARHGEF26,ARMC7,ASIC1,AURKA,BLM,C3orf62,CARMIL1,CCNF,CHTF8,CYB5B,DEPTOR,DIDO1,DPYSL5,DUSP5,EME1,ERCC6L,ERMP1,ETV1,ETV6,FCHSD2,GADD45A,GCH1,GPCPD1,HDAC8,HK2,HLTF,HSPA2,IPP,IRF2BP2,KANK2,KLF4,KNL1,LARS2,MEGF9,MGME1,MYO18A,NAA40,NDRG1,NFIL3,NR1D1,NRBF2,NT5DC3,PARP1,PARP9,PEX12,PLK1,POLE2,RAB20,RAD51,RPA1,RTN4IP1,SAMD4A,SERPINE1,SH2D5,SHPK,SKP2,SYNE2,TANGO6,TCEANC2,TCTN2,TDRKH,TMEM19,TMEM268,TMPO,TNIP1,TOLLIP,TRERF1,TRIB1,TUBGCP5,UEVLD,UPP1,VANGL1,ZFAND2A,ZMYM3 | 490 (7) |
| forskolin | NA | chemical toxicant | Activated | 4.91e+00 | 0.0e+00 | Acan,ACE,ADAMTS1,ADAMTS4,ADGRA1,AGL,Akr1b7,AQP3,AQP5,AXIN2,BAMBI,BCL2L11,BCL3,BHLHE40,CCL5,CCND1,CD200,CD55,CD86,CDKN1A,CDKN1C,CFTR,CGREF1,CHGB,CIDEC,COL18A1,CRISPLD2,CRYAA/LOC102724652,CXCL10,CYP27B1,DHRS3,DIO2,DUSP1,DUSP14,DUSP9,EFNB2,EIF5A,EPHA5,ERFE,ESR1,EZH2,FDX1,FOSL1,GADD45A,GADD45B,GAL,GBP1,GCH1,GEM,GFRA1,GJA1,GNRHR,GPRC5B,HHIP,HK2,HSD17B7,HSPA1A/HSPA1B,HSPA2,ICAM1,ID3,IER3,ING1,INHA,INHBB,JUN,KLF4,LEP,LGALS12,MAP2K3,MAP3K5,MMP19,Mt1,MYCN,NCOA2,NFIL3,NPTX2,NR4A2,NR4A3,NT5E,OXTR,PAWR,PCNA,PDE4A,PDE4B,PDE4D,PDLIM3,PENK,PIM3,PLAT,PLIN3,POP5,PRKX,PTP4A1,PTPN1,PTPRN,RAB20,RAPGEF3,REN,RET,RNF4,RRM2,SCARB1,SENP2,SERPINB2,SERPINE1,SFTPB,SLC2A5,SLC6A17,SLC7A11,Slco1a4,SMARCA1,SPRED3,SSTR1,STAT1,STAT3,STK24,TH,THBS1,TK1,Tpm4,TRIB1,TTF2,UCP2,UPP1,USP18,VCAN,VCL,VDR,VGF | 666 (20) |
| Ttc39aos1 | NA | other | Activated | 4.40e+00 | 0.0e+00 | ATP10A,CCL5,CXCL10,DHX58,DTX3L,HEG1,IFI16,IFI35,IFI44,IFIH1,Igtp,IRF1,IRF7,IRF9,MOV10,Oas1b,OAS2,PARP14,PARP9,RNF213,RTP4,SERPINE1,TNFSF10,TRIM6-TRIM34,USP18,ZNFX1 | 176 (7) |
| CREB1 | -7.20e-01 | transcription regulator | Activated | 4.24e+00 | 0.0e+00 | ADGRA1,ALOXE3,ATF1,AURKA,BHLHE40,BPIFC,CABP7,CALN1,CARS1,CCND1,Ccnjl,CDK19,CDKN1A,CGREF1,CHGB,CSRP2,DIO2,DUSP1,DUSP14,EGR2,EHD4,ERC2,ETV6,EXOSC6,FGF13,FRMD6,FUT7,GADD45A,GADD45B,GAL,GEM,GFRA1,GPR83,GRIA3,HLA-G,HMGCS1,HSPA5,IER3,INHA,IRF7,JUN,KLF4,Ldha/RGD1562690,LEP,LSM11,LSS,MARCKSL1,Meis1,mir-154,MYBL2,NARF,NFIL3,NKX6-2,NOS1,NPTX2,NR4A2,NR4A3,OXNAD1,PCNA,PDE3B,PENK,PIM3,PLAT,PLXNC1,PRCP,PTPRN,RAD54L,RELT,REM2,REN,SEMA4A,SFTPB,SLC16A1,SOCS2,SPRED3,SRD5A1,SREBF1,SSTR1,STAT3,TFRC,TH,Tpm4,TPT1,UPP1,VGF,WARS2,ZDHHC23,ZFPM2 | 664 (19) |
| IRGM | NA | enzyme | Activated | 4.17e+00 | 0.0e+00 | CXCL10,DHX58,GBP1,GBP4,HELZ2,IFI16,IFI35,IFI44,IFI44L,IFIH1,IRF7,IRF9,ISG20,MX1,OAS2,STAT1,STAT2,TLR3,TNFSF10,TRIM21,USP18 | 355 (8) |
| SN-011 | NA | chemical reagent | Activated | 4.13e+00 | 0.0e+00 | CDKN1A,CXCL10,DTX3L,GBP4,GBP5,IFI44,IFIH1,IRF1,IRF7,IRF9,MOV10,OAS2,PML,RTP4,SLFN5,SP110,STAT1,STAT2,TNFSF10,TRIM21,USP18 | NA |
| IL4 | NA | cytokine | Activated | 4.08e+00 | 0.0e+00 | ABLIM1,ACTG1,ADAMTS4,ARSB,ASCC3,B4GALNT1,B4GALT7,BCAT1,BCL3,BHLHE40,BIN1,BIRC2,BOP1,CCDC86,CCL24,CCL5,Ccl6,CCND1,CCNE1,CCRL2,CD200,CD200R1,CD300LF,CD55,CD83,CD86,CDKN1A,CISH,CKB,CLCN3,CLEC10A,CLEC7A,COL18A1,CPOX,CRISPLD2,CSF2RB,CSTB,CX3CL1,CXCL10,CXCL11,CXCR3,CYB561A3,DARS2,DDX42,DHX58,DUSP14,DUSP28,EGR2,EIF4A1,EPAS1,EPRS1,EXT1,F2R,FADS1,FSCN1,FUT7,FYCO1,GADD45B,GBP5,GJA1,GNA15,GSDMC,GSTT2/GSTT2B,HDAC1,HK2,HOPX,HSPA1A/HSPA1B,ICAM1,ID3,IDE,IER3,IFI16,IFI44,IFI44L,IFIH1,Igtp,IL12RB1,IL15RA,IL18,IL19,IL1R2,IL33,IRAK2,IRF1,IRF7,IRF9,Irgm1,ISG20,ITGA2,ITGAV,ITGAX,JAK2,JUN,KCNH1,KCNH2,KLF4,Klrk1,LACC1,LEF1,LILRB4,LIPG,LSR,LTA4H,LY6D,MAP2K3,MAP3K5,MAPKAPK2,MEFV,MERTK,METRNL,MOV10,MSH2,MYOF,NCL,NDRG1,NEDD9,NFATC1,NFIL3,NMD3,NOCT,NOMO1 (includes others),NR4A3,OAS2,ORAI1,ORC5,PAWR,PCYOX1L,PDE1B,PDE4B,PEX14,PIK3R5,PLSCR1,POLA1,POLE2,PPM1G,PRKCD,PRKDC,PRMT1,PTBP2,PTGDR2,PTPN1,RAB30,RNF213,RPUSD3,SAMD4A,SCARB1,Scd2,SDC1,SEMA4A,Serpinb6b,SERPINE1,SFTPC,SH3BP2,SLAIN1,SLC7A5,SOCS1,SOCS2,SPATA2,SREBF1,STAT1,STAT2,STC2,TFAP4,TFRC,TGM2,THBD,TIMP3,TINAGL1,TLR2,TNC,TNFSF18,TNIP1,TRAF1,UPP1,USP18,VDR,XRCC6,ZSWIM4 | 720 (17) |
| TRIM24 | NA | transcription regulator | Activated | 4.05e+00 | 0.0e+00 | CCL5,CXCL10,DHX58,EIF5A,EPSTI1,FLRT3,GBP4,Gm12854/S100a11,IFI35,IFI44,Ifi47,IFIH1,Igtp,IRF1,IRF7,IRF9,Irgm1,JAK2,MOV10,PACSIN3,RTP4,S100G,SERPINE1,SOCS1,SOCS2,STAT1,STAT2,TLR2,TRIM6-TRIM34,TRPV6,USP18 | 585 (17) |
| PNPT1 | -5.60e-01 | enzyme | Activated | 3.97e+00 | 0.0e+00 | CCL5,CDKN1A,CXCL10,GBP4,IFI16,IFI44,IFIH1,IRF7,Irgm1,Oas1b,Oasl2,PARP14,PARP9,RNF213,RTP4,STAT1,STAT2,USP18 | 560 (10) |
| PTTG1 | 2.30e-01 | transcription regulator | Activated | 3.89e+00 | 0.0e+00 | ATM,CCND1,CDKN1A,DCLRE1A,FANCG,MLH1,MLH3,MPG,MSH3,NPRL3,PARP2,PINX1,POLD1,POLI,POLK,RAD51C,RAD52,RAD9B,WRN,XPA,XRCC6 | NA |
| norepinephrine | NA | chemical - endogenous mammalian | Activated | 3.87e+00 | 0.0e+00 | ADRB3,ATP2A2,CRY1,CRY2,Dclk1,DIO2,DUSP1,FDX1,GEM,GMNN,HHIP,IRAK2,LAMB3,LEP,LRRC73,NR4A3,PCNA,PDE10A,PDE4B,PDE4D,SERPINE1,SLC6A17,TFRC,TINAGL1,UBE2I,Xpot | 791 (21) |
| Irgm1 | -1.28e+00 | other | Activated | 3.85e+00 | 0.0e+00 | CCL5,CXCL10,DHX58,GBP4,GBP5,GSDMD,ID3,IFI16,IFI35,IFI44,IFIH1,IRF1,IRF7,IRF9,ISG20,LILRB4,Oas1b,OAS2,Oasl2,RRM2,STAT1,TK1,TLR2,TLR3,TRIM21,UBE2C,USP18 | 624 (19) |
| EPAS1 | 6.50e-01 | transcription regulator | Activated | 3.85e+00 | 0.0e+00 | ANGPTL4,BHLHE40,CA9,CAV1,CCND1,CDCP1,CDKN1A,CKB,DGAT1,EIF5A,FMO5,GADD45B,GCHFR,GJA1,HMGCS1,HSPA5,ICAM1,INHBB,Irs3,ITGA2B,ITGAV,L1CAM,LEP,LOX,MAFF,MYOM2,NDRG1,NEK8,NFIL3,NT5E,PDGFB,RASSF1,RET,SERPINE1,SFTPB,SLC7A5,SREBF1,STC2,TRIM21 | 670 (23) |
| KLF6 | -3.60e-01 | transcription regulator | Activated | 3.73e+00 | 0.0e+00 | AGT,ANGPTL4,ATP2A2,BCL2L11,BCL3,CCL24,CCL5,CD83,CD86,CDKN1A,CSF2RB,Cxcl3,EGR2,EHD1,Eif1,EXT1,GADD45B,GCH1,HIBCH,HK2,HSPA5,ICAM1,IL15RA,IRAK2,IRF1,ITGA5,JAK2,MEFV,NLRP3,NR1D1,OSMR,PARP14,PCNA,PDE4B,PIK3R5,PLAT,PTPN1,SDC1,SERPINB2,SERPINH1,SGMS2,SLC25A28,SLC31A1,SOCS1,STAT3,TNIP1,TRAF1,UPP1,VCAN,ZNFX1 | 671 (23) |
| tetradecanoylphorbol acetate | NA | chemical drug | Activated | 3.58e+00 | 0.0e+00 | Acan,ACE,ADAMTS1,ADAMTS4,ADRB3,AGER,AGT,ALOXE3,ANGPT1,ANGPTL4,ARF4,ARHGAP32,ATM,ATP23,ATP2A2,AURKA,BCAR1,BCL3,BLM,BMP7,CA11,CAV1,CAV2,CCL5,Ccl6,CCND1,CCNE1,CD55,CDCP1,CDKN1A,CFTR,CIDEC,CLEC12B,CXCL10,Cxcl3,CYP27B1,Cyp3a25 (includes others),DIO2,DUSP1,DUSP5,E2F4,EFNB2,EGR2,EGR3,EIF4A1,EIF4E,EIF5A,EIF6,EPOR,ERCC6L,ESR1,FAHD1,Fam13a,FDX1,FGF7,FJX1,FOSL1,FZD1,GADD45B,GAL,GEM,GJA1,GML,GNAZ,GNRHR,GPR83,GPRC5A,HAS1,HK2,HMBS,HMGA1,HNF1A,HOPX,HOXB7,HSPA2,HSPA5,ICAM1,ID3,IER3,IFI16,IFI35,IL12RB1,IL18,INHBB,IRAK4,IRF1,IRF7,ITGA2,ITGA2B,ITGA5,ITGAX,JUN,KAT2B,KCNA5,KLF4,LAMB3,LAT,LIPC,LIPG,LYRM2,MAD1L1,MAST4,MEFV,MMP19,MRPS12,MTRR,NCOA7,NFATC1,NFIL3,NFKBIB,NLRP3,NOCT,NQO1,NR4A2,OLR1,PAQR7,PCNA,PDE3B,PDE4D,PLAT,PLIN3,POLR1C,PRKCB,PRKCD,PRKX,PTGFR,PTPN1,PTPRN,PTPRO,REN,RIOX2,RNF4,SCNN1A,SDC1,SERPINB2,SERPINE1,SFTPB,SKAP2,SLC16A1,SLC28A3,SLC7A11,SMPD1,SOCS1,STAT1,STAT3,Tchh,TEKT1,TEX9,TGM1,TH,THBS1,TK1,TLR2,TLR3,TLR5,TMEM150C,TNFRSF10A,TNFRSF21,TNFSF10,TRAF1,TRIM45,TUBB6,UGCG,UPP1,VCAN,VCL,VDR,VEGFC,WRN,ZPBP2 | 817 (19) |
| TGFB1 | -4.10e-01 | growth factor | Activated | 3.51e+00 | 0.0e+00 | ABCD1,Acan,ACE,ACSL3,ADAM10,ADAMTS10,ADAMTS4,ADGRA1,ADGRG2,ADORA1,ADRA1D,AK1,AMD1,ANGPT1,ANGPTL4,ANPEP,ANXA11,APLNR,APOC2,ARF4,ASNS,ATF4,ATG7,ATM,ATXN1,AURKA,AXIN2,B4GAT1,BAD,BAMBI,BCAT1,BCL2L11,BCL3,BDKRB2,BHLHE40,BIN1,BMP7,CALML3,CARS1,CAV1,CAV2,CCDC28A,CCL24,CCL5,CCND1,CCNE1,CCNF,CCRL2,CD200R1,CD55,CD83,CD86,CDC25A,CDC42EP3,CDKN1A,CDKN1C,CEACAM1,CIDEC,CLDN4,CLIC4,COL18A1,COL2A1,COMP,CORO1C,CREB3L1,CSRP2,CX3CL1,CXCL10,CXCR3,CYP27B1,DAAM1,DDB2,DEPTOR,DLL3,DNAJA1,DNAJB6,DSP,DUSP1,EGR2,EGR3,EHD1,ELK3,ELN,ELOVL5,ENO3,EPRS1,ERCC5,EXT1,EXT2,EZH2,F2R,FAM107A,FGF12,FGF7,FGF9,FOSL1,FSCN1,FTL,FUT7,FXYD5,FZD1,FZD7,GADD45A,GADD45B,GAL,GAS1,GBP1,GEM,GJA1,GMPR,GNAZ,GPR146,GPR158,GPR83,GPRC5A,GPRC5B,GREM1,GRIN2C,GUCY2F,GYG1,H6PD,HAPLN3,HAS1,HK2,HLTF,HMGA1,HMGCS1,HNF1A,HOOK1,HOPX,HSPA1A/HSPA1B,HSPA5,ICAM1,ID3,ID4,IDH1,IER3,IFI16,IFIH1,IL18,IL33,ING1,INHA,INHBB,IRAK2,IRF1,ITGA11,ITGA2,ITGA5,ITGAV,ITGAX,JUN,JUP,KDELR2,KDM5B,KLF4,L1CAM,LAMB3,LAMC2,LASP1,LEF1,LEP,LOX,LSR,LTA4H,LTBP1,MAD1L1,MAP2K3,MAPKAPK2,MARK3,MCM4,ME2,MEFV,METRNL,mir-154,MPV17L,MTHFD2,MTRR,MYBL2,MYCN,MYO10,MYOF,NDST1,NEDD9,NET1,NFATC1,NLRP3,NOP58,NOS1,NPTXR,NR1H3,NR4A2,NR4A3,NT5E,NUP62,OGG1,OLFM2,OLR1,P2RY14,P4HA1,PARP1,PARP3,PBX1,PCNA,PDE4A,PDE4D,PDGFB,PDGFC,PDK2,PDLIM5,PIGF,PLA1A,PLAT,PLEK2,PLK1,PLSCR1,PLXNC1,PMEPA1,PML,POLD1,POLE2,PRC1,PROCR,PROM1,PTPRN,RAD1,RAD51,RAD51C,RAMP2,RAPGEF3,RASL11B,RASSF1,RBL2,RBM3,RHOD,RND1,RORA,RRM2,SCARB1,Scd2,SDC1,SEMA4A,SERPINE1,SERPINH1,SFTPB,SFTPC,SHMT1,SKIL,SLC13A3,SLC23A2,SLC35A5,SLC3A2,SLC7A5,SMC2,SOCS1,SORD,SPIDR,SRFBP1,ST3GAL5,STAT1,STAT3,STC2,STRAP,TFAP4,TFRC,TGFB2,TGFBR3,TGM2,THBD,THBS1,TIMP3,TLE4,TLR2,TNC,TNFRSF10A,TNFSF10,Tpm4,TPSAB1/TPSB2,TRAF1,TSC22D1,TUBB2A,TUBB4B,TXNDC5,TXNRD1,UBE2J1,ULK2,UNC119,VAT1L,VCAN,VCL,VDR,VEGFC,WNT5A,WNT5B,XRCC4,YBX1,ZFPM2,ZFYVE9,ZMIZ1,ZWINT | 857 (22) |
| RNASEH2B | -2.80e-01 | other | Activated | 3.49e+00 | 0.0e+00 | ATP2C1,CCL5,CDKN1A,CXCL10,DHX58,EPSTI1,GSDMD,HELZ2,IFI35,IFI44,IFI44L,IFIH1,Igtp,IRF1,IRF7,ISG20,MOV10,MX1,NCOA7,NLRC3,NLRP3,OAS2,PARP14,PARP9,PHLDA3,PROCR,RTP4,SP110,TRIM21,USP18 | NA |
| nitrofurantoin | NA | chemical drug | Activated | 3.27e+00 | 1.0e-02 | ACTG1,ADAMTS1,AMD1,ASNS,CCND1,COL2A1,CXCL10,EIF4E,FGF7,GADD45A,GTPBP4,HMGCS1,HSPA5,IER3,LIPC,LOX,Mt1,NQO1,NR1H4,PCNA,PLAT,PRKCB,SDC1,TIMP3 | NA |
| 5-azacytidine | NA | chemical drug | Activated | 3.23e+00 | 0.0e+00 | ATM,BTG3,CAV1,CDC25A,CDKN1A,DUSP1,ESR1,EZH2,FANCC,FANCG,FOSL1,GADD45A,HK2,HSPA5,IRF7,KLF4,LOX,MAFF,MLH1,Mt1,NDRG1,PAH,PNRC1,RASSF1,RRM2,SLC3A2,SLC7A5,SOX11,TGM2,THBS1,UPP1,XRCC4,XRCC6 | 627 (23) |
| Vegf | NA | group | Activated | 3.21e+00 | 0.0e+00 | ACE,ACKR3,ADAM10,ADAMTS1,ADGRF5,ANGEL1,ANGPT4,ANGPTL4,ANPEP,APLNR,ARHGAP18,ASNS,AURKA,AXIN2,BCL2L11,BMP7,BTBD3,C1QTNF1,CCNF,CDC25A,CRY1,CSE1L,CXCL10,CXCL11,DDX11,DIO2,DUSP5,EFNB2,EGR2,EGR3,ELN,FANCG,FGF16,FOSL1,FRMD6,GEM,GMNN,GPRC5B,GRB10,GRB14,GTDC1,HK2,HMMR,HOPX,ICAM1,IL15RA,IL18,INHBB,IRF1,ISG20,ITGA2,JUN,LEF1,LEP,LRAT,LRP2,MAD2L1,MAP2K3,MAPKAPK2,MPHOSPH10,MYCN,NCOA2,NEK3,NFATC1,NR4A2,NR4A3,NRG1,OSMR,OXTR,P2RY14,PEX5,PLK1,PLPP3,PPAN,PRC1,PRDM16,PRKCB,RAD51,RGS9,SERPINB2,SH3TC2,SKP2,SMC2,SOCS2,SSTR1,STAT3,Sult1d1,THBD,TLR3,TNC,TRIB1,UBE2C,UGCG,VASH1,VEGFC | 806 (24) |
| MYC | 5.80e-01 | transcription regulator | Activated | 3.20e+00 | 0.0e+00 | ABCB10,ABCC4,ABCD1,ACTN4,ADAMTS1,AFMID,AHCY,AMD1,ANGPT1,ANGPTL4,Arf2,ASCL2,ASNS,ATF4,B4GALT7,BCAT1,BCL2L11,BIN1,BIRC2,BMPER,BOP1,BZW2,CAV1,Ccl6,CCND1,CCNE1,CD86,CDC25A,CDC42EP3,CDKN1A,CIDEC,CLIC4,CNTRL,COL2A1,CSE1L,CSRP2,CSTB,CXCL10,CXCL11,DDB2,DDX11,DDX27,DSP,DUSP1,DUSP5,EGR2,EIF3D,EIF4A1,EIF4E,EIF5A,EXT2,EZH2,F2R,FARP1,FBN2,FBXO32,FOSL1,GADD45A,GADD45B,Gar1,GAS1,GBP4,GFER,GJA1,GLG1,GREB1,GTF2F2,H6PD,HIVEP2,HK2,HMGA1,HNRNPA1,HNRNPD,HSPA14,HSPH1,ICAM1,ID3,IDH1,IER3,IFI16,IFI35,IFI44,IFI44L,IFIH1,IRF6,IRF7,IRF9,ISG20,ITGAX,JARID2,JUN,KIF16B,KIFAP3,KLF4,LAMB3,Ldha/RGD1562690,LEP,LGR5,LOX,MAD2L1,ME2,MSH2,Mt1,MTHFD1,MX1,MYCN,NCL,NDRG1,NF2,NOCT,NOP56,NOP58,NQO1,NR1H3,Oasl2,OAZ1,OLR1,PAK1,PARP1,PCNA,PLA1A,PLK1,PLSCR1,PMEPA1,PML,POLD1,PPAT,PRKACB,PRMT1,PROM1,PTBP1,RAD51,REN,RFFL,RIOX2,RPL3L,RPL9,RPS18,RRM2,RRP1B,RRS1,SCARB1,Scd2,SEMA4A,SEPHS2,SERPINE1,SERPINH1,SHMT1,SKP2,SLC16A1,SLC25A21,SLC38A1,SLC3A2,SLC7A5,SNAPC4,SRD5A1,SREBF1,STAT1,STAT3,TAF1D,TEAD3,TFAP4,TFRC,TGFB2,TGM1,THBS1,TIAM1,TLE4,TNC,TNFRSF10A,TNFSF10,TXNRD1,UBA2,UBE2C,UBE2I,UNC119,USP18,VEGFC,WNT5A,WRN,XPO1,YBX1,YRDC | 835 (21) |
| STAG2 | -2.90e-01 | other | Activated | 3.17e+00 | 0.0e+00 | CCRL2,CXCL10,CXCL11,DHX58,HELZ2,IFI35,IFI44,IFI44L,IFIH1,IRF7,IRF9,ISG20,PARP14,PARP9,PLSCR1,SP110,USP18 | 439 (7) |
| uric acid | NA | chemical - endogenous mammalian | Activated | 3.11e+00 | 1.0e-02 | ACE,AGT,ATF1,ATM,CCL5,CD86,DDB2,ICAM1,IL18,IRF7,ITGAV,NLRP3,OGG1,PARP1,PARP2,PRIM2,PRKDC,RAD51,TDP1,USP18 | 588 (19) |
| 3-deazaneplanocin | NA | chemical drug | Activated | 3.03e+00 | 8.0e-02 | AKNA,CDKN1A,EZH2,FBXO32,FZR1,LAMB3,MAP3K14,SLC5A7,SOX12,TIMP3 | NA |
| GSTO1 | 5.00e-02 | enzyme | Activated | 3.00e+00 | 0.0e+00 | CHAC1,EIF3D,F11R,IRF9,LAMA5,NAV3,NPTXR,NR4A2,PARP9,PBX1,PDE4B,PDLIM5,SLFN5,STAT1,THBS1,TIAM1 | NA |
| PIM1 | 5.60e-01 | kinase | Activated | 2.98e+00 | 6.0e-02 | ATP2A2,CAV2,CDC25A,CDKN1A,FOSL1,GNL3,OSCAR,SKP2,SOCS1 | NA |
| nilotinib | NA | chemical drug | Activated | 2.95e+00 | 2.0e-02 | ABCC4,ANAPC1,ATM,BCL2L11,JAK2,MAD2L1,MCM3,ORC5,PRKDC | NA |
| ATF4 | 9.00e-01 | transcription regulator | Activated | 2.93e+00 | 0.0e+00 | ADAM10,AMPD1,ASNS,ATF4,ATXN1,BCAT1,CA9,CARS1,CD55,CDKN1A,CHAC1,CPOX,FUT7,GADD45A,GCH1,GRB10,HSPA5,JUN,KLF4,MID1IP1,MTHFD2,NDRG1,NR1H3,OSMR,PENK,PRKDC,SH3BP2,SLC38A1,SLC3A2,SLC7A11,SLC7A5,SNTB1,SREBF1,STAT3,STC2,TGFB2,TNIP1 | 708 (22) |
| HIF1A | -1.90e-01 | transcription regulator | Activated | 2.91e+00 | 0.0e+00 | ABCC8,ACE,ADAM10,ADAMTS1,AGT,ANGPTL4,ASNS,ATP2A2,AURKA,AXIN2,BCL6B,BCS1L,BHLHE40,BIRC2,CA9,CARS1,CAV1,CCL5,CCND1,CCRL2,CDCP1,CDKN1A,CXCL10,Cxcl3,EIF4E,EIF5A,ENO3,EPAS1,EPOR,FSCN1,FUT7,GADD45B,GCHFR,GJA1,GRIN1,HES6,HK2,HSPA5,ICAM1,IFI16,INHBB,ITGA2B,ITGA5,ITGAV,JUN,JUP,L1CAM,LEP,LOX,MAFF,MBD2,NDRG1,NEK8,NR4A3,NT5E,NUDCD2,P4HA1,PDGFB,POMK,PROM1,RAB20,RASSF1,RET,RIOK3,SERPINE1,SLC39A7,SPOP,SRD5A1,STAT1,STAT2,STAT3,STC2,TFRC,TGFB2,THBS1,TLR2,TMEM19,TNFSF10,TRIM21,VEGFC | 741 (20) |
| PGR | 8.00e-02 | ligand-dependent nuclear receptor | Activated | 2.91e+00 | 0.0e+00 | ACE,ADAMTS1,AMD1,ATXN1,BIRC2,CCND1,CDC42EP2,CDH24,CDKN1A,CDKN1C,CLDN15,ELN,EPAS1,ESR1,FLRT3,GAL,GBP1,GNRHR,GPRC5A,GRB10,GREB1,GRIA3,HSPA2,ICAM1,IER3,IFI16,IFI35,IFI44,IFI44L,IRF7,ITGA11,ITGA2,ITGAX,KCNH2,KIF18B,KLF4,LAMB3,LCP1,LDLRAD4,LOX,MAD2L1,MAP2K3,MPHOSPH10,MX1,MYCN,MYO10,NDRG1,NEDD9,NET1,OAS2,OGG1,PCNA,PDGFB,POLD1,PPIF,PTP4A1,RAD51,SBK2,SCUBE3,SCX,SDC1,SERPINE1,SERPINH1,SFI1,SLC7A5,STAT1,STAT3,TGFB2,TK1,TNC,TNFRSF21,UGCG,VCAN,VCL,VDR | 846 (22) |
| isoproterenol | NA | chemical drug | Activated | 2.88e+00 | 0.0e+00 | ACE,ACSL3,ADRB3,AGT,APLNR,AQP5,AURKA,BCL2L11,CAV1,CTF1,DHRS3,DIO2,FOSL1,HSD17B7,IL18,JUN,LEP,LGALS12,MERTK,NLRP3,NOS1,NR4A3,PDGFB,PLAT,PNPLA2,REN,TGFBR3,TH,UCP2 | 829 (23) |
| Notch | NA | group | Activated | 2.86e+00 | 0.0e+00 | ABLIM1,AGT,CD300LF,CDKN1A,CLEC10A,CSF2RB,DLL3,DUSP1,GADD45B,GFRA1,ID3,IDH1,INPP5J,KBTBD11,NET1,NFATC1,PIK3AP1,PROX1,SH2D5,SKAP2,SRFBP1,TGM1,VCL | 694 (21) |
| TREX1 | -8.00e-02 | enzyme | Activated | 2.85e+00 | 0.0e+00 | ATP2C1,CCL5,CD86,CDKN1A,CXCL10,DHX58,DTX3L,EPSTI1,GBP4,GBP5,GSDMD,HELZ2,IFI16,IFI44,IFI44L,IFIH1,IL33,IRF1,IRF7,IRF9,ISG20,MEFV,MOV10,MX1,NCOA7,NLRC3,NLRP3,OAS2,PARP14,PARP9,PLPP3,PML,PROCR,RTP4,SLFN5,SP110,STAT1,STAT2,TNFSF10,TRIM21,USP18 | 357 (15) |
| cicaprost | NA | chemical drug | Activated | 2.83e+00 | 1.0e-02 | ADAMTS1,CSF2RB,FGF7,HAS1,SDC1,THBD,VCAN,VDR | 434 (7) |
| DUX4 | NA | transcription regulator | Activated | 2.83e+00 | 1.0e-01 | BIN1,CCND1,FBXO32,FZD1,FZD7,KHDC1L,TRIM63,WNT5A | NA |
| BMP2 | -2.70e-01 | growth factor | Activated | 2.82e+00 | 0.0e+00 | Acan,BHLHE40,BTG3,CCND1,CDKN1A,CLIC4,COL2A1,CREB3L1,EVC2,FGF12,FZD1,GADD45B,GFRA1,GREM1,ID3,ID4,IFI16,JUN,KLF4,L1CAM,MRAS,NFATC1,NFYA,PCSK6,RAD1,RET,SPINT1,TGM2,TH,TIMP3,TMEM119,VCAN,VDR,ZBTB2 | 716 (21) |
| FOXM1 | 3.90e-01 | transcription regulator | Activated | 2.81e+00 | 0.0e+00 | ACE,AURKA,AXIN2,CAV1,CCL5,CCND1,CCNE1,CCNF,CDC25A,CDKN1A,CXCR3,ESR1,EZH2,FZD1,ITGA5,ITGAV,JUN,LEF1,LOX,MYCN,PCNA,PLK1,PRC1,PROM1,RRM2,SFTPB,SKP2,STAT3,VCAN | 669 (22) |
| CTCF | -1.50e-01 | transcription regulator | Activated | 2.80e+00 | 1.0e+00 | AURKA,CD83,CDKN1A,CDKN1C,CXCL10,FADS1,HSPA1A/HSPA1B,IL12RB1,MYCN,SLC7A11,TLR2 | NA |
| KRAS | 3.60e-01 | enzyme | Activated | 2.80e+00 | 0.0e+00 | ABCC4,ADAMTS1,AGER,AGT,AKAP5,ANPEP,AQP5,ASCL2,ASPH,ATG7,ATOH8,AURKA,AXIN2,B4GAT1,BZW2,CAV1,CCND1,CCP110,CDKN1A,CEACAM1,CFTR,CHSY1,CLEC10A,CLIC5,CPM,CPOX,CSE1L,CSF2RB,CX3CL1,CXCL10,Cxcl3,Dclk1,DDR1,DUSP1,DUSP5,E2F4,EGFL6,EGR2,EIF4E,EIF5A,EIF6,ELN,ETV1,EXT1,EXT2,EZH2,FGF7,FOSL1,FUT10,GADD45A,GALNT3,GAS1,GJA1,GMNN,GNPTAB,HK2,HMGA1,HNRNPD,HOPX,HSPA5,IER3,IL33,IRF1,IRF9,JUN,L1CAM,LAMA5,LAMB3,LAMC2,LEF1,LIPG,LLGL2,LOX,LRRC49,MICOS10-NBL1/NBL1,MID1IP1,MTHFD1,MTRR,Muc1,MUC13,MX1,MYBL2,MYCN,MYOF,NCL,NDOR1,NETO2,NFKBIB,NLRP3,NOS1,NQO1,NT5E,NUAK2,Oasl2,P2RY14,PAK1,PALM,PARG,PAWR,PDE4B,PDLIM5,PLA1A,PLAT,PLK1,POMK,POR,PRC1,PRKCD,PRPF19,RAB20,RAI14,RRP12,RRS1,SCARB1,SERPINB2,SERPINE1,SFTPB,SFTPC,SKP2,SLC27A6,SLC3A2,SLC6A14,SLC7A11,SREBF1,STAT1,STAT2,STAT3,TCERG1,TGM2,THBD,THBS1,TIMM9,TIMP3,TINAGL1,TK1,TLR2,TMEM109,TNC,TNFRSF10A,TNFSF10,TRIB1,TSPAN1,UBE2I,UPP1,VAPA,VCAN,ZFAND2A | 834 (25) |
| brefeldin A | NA | chemical - endogenous non-mammalian | Activated | 2.78e+00 | 1.2e-01 | ATP2A2,ESR1,GADD45B,GJA1,HSPA5,KLF4,OXTR,THBS1 | NA |
| TNFSF11 | NA | cytokine | Activated | 2.74e+00 | 0.0e+00 | AURKA,CAV1,CCL5,CCND1,CCNE1,CD300LF,CD83,CDKN1A,CIAO1,CKB,CREBRF,CUL4A,DUSP1,ECT2,EGR2,EHD1,ESR1,FGR,FOSL1,GADD45B,GCH1,GLRX,GRB10,ICAM1,IER3,IL15RA,ITGA5,ITGAV,JUN,LAT,LDB2,LSR,MARCKSL1,NFATC1,NFIL3,NFKBIB,NME6,NR1H3,OSCAR,PHLDA3,PLK1,POR,PRMT1,SDC1,SENP2,Serpinb6b,SERPINE1,SLC6A4,SLC7A7,SOCS1,SOX8,STAT1,TLR2,TNIP1,TRAF1,USP18,VRK1 | 708 (18) |
| GDF2 | -1.00e-01 | growth factor | Activated | 2.71e+00 | 2.0e-02 | BAMBI,CAV1,CDH9,EFNB2,GADD45B,GJA4,HSPB8,ICAM1,ID3,MAP2,MDFI,PIM3,PROX1,RASL11B,SLC3A2,SLC7A5,SLCO2A1,SOCS2,SREBF1,VAT1L | NA |
| BHLHE40 | 9.50e-01 | transcription regulator | Activated | 2.69e+00 | 0.0e+00 | ATP2A2,CAV1,CCRL2,CD86,CSF2RB,Cxcl3,EPSTI1,EXT1,GCH1,GLRX,HAS1,HK2,HSPA5,IER3,IFI16,IFIH1,IL12RB1,IL1R2,IRAK2,JAK2,Klrk1,LEF1,LOX,MAFF,MEFV,MERTK,MLH1,MTHFD2,NDRG1,NLRP3,OLR1,P2RY14,P4HA1,PARP9,PDE4B,PLSCR1,PNRC1,PPP2R3A,PROCR,SAP30,SGMS2,SLC15A2,SLC31A1,SOCS1,SORBS2,SREBF1,ST3GAL5,STAT1,STAT3,TGM2,TYK2,UPP1,ZNFX1 | 614 (11) |
| aldosterone | NA | chemical - endogenous mammalian | Activated | 2.69e+00 | 1.8e-01 | ACE,ADAMTS1,AGT,CCL5,CTF1,DUSP1,ELN,FOSL1,HHIP,HSPA5,ICAM1,LEP,LOX,OLR1,PROCR,PTPN1,SCNN1A,SCNN1G,SERPINE1,TPRG1 | NA |
| AR | -6.60e-01 | ligand-dependent nuclear receptor | Activated | 2.67e+00 | 0.0e+00 | ABCC4,Akap17b,Akr1b7,ALG14,AMD1,AQP3,ATAD2,ATP13A4,ATP2A2,ATP4A,B4GALNT1,BCL2L11,BOP1,Btnl10,CAV1,CAV2,CCL24,CCL5,CCND1,CDKN1A,CHTF18,CIT,CPNE8,EPAS1,ESR1,ESYT3,ETV1,FABP7,FGF7,GJA1,HOPX,HSPA5,HSPH1,ICAM1,IFIH1,IL17RE,INHA,INPP4B,ITGA2,KCNH2,KCNJ2,KDELR2,LAMA5,MAD2L1,MCM4,ME2,MICALL2,MRAS,MSI1,MTHFD2,NDRG1,NFATC1,NUSAP1,NXNL2,P3H2,P4HA1,PAQR7,PENK,PIM3,PLAT,PLK1,PMEPA1,PRKCD,RASSF3,REC8,REN,RNF128,RORA,SERPINE1,SKP2,SLC3A2,SLC45A3,SLC7A11,SRD5A1,STAT1,SYCE1,TEAD3,TGFB2,THBS1,TIMP3,TNFSF10,TSPAN8,TWF2,UBE2C,UNC5C,VCAN,VCL,VEGFC,ZFYVE19,ZWINT | 788 (22) |
| ACKR2 | 1.40e-01 | G-protein coupled receptor | Activated | 2.67e+00 | 0.0e+00 | CCL5,CXCL10,DHX58,IFI16,IFI44,Ifi47,IL20,IRF7,ISG20,OAS2,Oasl2,STAT1,STAT2,USP18 | 293 (8) |
| bucladesine | NA | chemical toxicant | Activated | 2.67e+00 | 0.0e+00 | Acan,ADAMTS1,AGL,AXIN2,BAMBI,BDKRB2,CASZ1,CCND1,CD86,CDKN1A,CXCL10,Dclk1,DIO2,Dmd,DUSP1,EGR2,EZH2,FDX1,FOSL1,GADD45B,GCH1,GEM,GJA1,GNRHR,HAS1,HCRTR1,HHIP,ICAM1,ID4,IGFALS,IL12RB1,INHBB,IRAK2,IRF1,JUN,LAMB3,LEP,LGALS12,LRRC73,MAP3K5,Mt1,MYCN,NR4A2,NR4A3,PDE10A,PDE4B,PDE4D,PLIN3,RET,SCARB1,SERPINE1,SFTPB,SFTPC,SLC6A17,SLC6A4,Slco1a4,SMARCA1,SOX7,TGFB2,TGFBR3,TH,THBD,TINAGL1,VDR,VGF,Xpot | 767 (21) |
| geldanamycin | NA | chemical drug | Activated | 2.66e+00 | 1.0e-02 | AKR1B1,AURKA,BIN1,CARS1,CCND1,CDH24,CDH9,CHORDC1,CHRM1,DNAJB1,EGR3,FLT3,GBP1,GJA1,HDAC11,HLTF,HMGA1,HSPA1A/HSPA1B,HSPA5,IFI16,IRF1,JUN,KCNA5,KNL1,MCM3,MLH1,NLRP3,PAK1,PARP1,PLK1,PRIMA1,SLC5A1,SMARCA1,STAT1,TH,THBD,TTC1 | 735 (20) |
| 1-chloro-2,4-dinitrobenzene | NA | chemical drug | Activated | 2.65e+00 | 0.0e+00 | IL19,IL1R2,IL20,NQO1,SCARB1,SLC7A11,TXNRD1 | NA |
| IGF1 | -4.40e-01 | growth factor | Activated | 2.64e+00 | 0.0e+00 | Acan,AKR1B1,ANPEP,APLF,ATM,BAD,BCL2L11,BHLHE40,CCL5,CCND1,CCNE1,CDKN1A,CGNL1,CISH,COL20A1,COL2A1,CYP27B1,DUSP1,EFNB2,EGR2,EIF4E,ELN,EPAS1,ESR1,ETV6,FBXO32,FJX1,GADD45A,GRIN1,HMGA1,HOPX,HSPA1A/HSPA1B,HSPA5,ICAM1,IER3,IL18,INHA,ITGA5,ITGAV,JUN,KCNJ5,LASP1,LEP,LGALS12,LOXL3,MYCN,ORAI1,OSMR,PARP1,PCNA,PDLIM2,PENK,PKP2,PPP3CC,RDX,RMND5B,RND1,RTKN2,Scd2,SERPINE1,SLC12A5,SLC23A2,SRD5A1,SREBF1,TGM2,TH,THBS1,TK1,TMED1,TRPV1,TTF2,UBE2G1,UGCG,VEGFC | 796 (20) |
| USP8 | -6.90e-01 | peptidase | Activated | 2.63e+00 | 4.0e-02 | CXCL10,HNRNPD,IFI16,IRF7,Irgm1,Oas1b,OAS2,Oasl2,STAT1,STAT2,TLR3 | NA |
| copper gluconate | NA | chemical drug | Activated | 2.62e+00 | 1.0e-02 | ASCC3,BIVM,DCLRE1A,MSH2,POLI,RAD51C,SMC2 | NA |
| disulfiram | NA | chemical drug | Activated | 2.62e+00 | 2.0e-02 | ASCC3,BIVM,DCLRE1A,MSH2,POLI,RAD51C,SMC2 | NA |
| AKT inhibitor VIII | NA | chemical reagent | Activated | 2.62e+00 | 7.0e-02 | BAD,BCL2L11,ICAM1,PARP1,SRD5A1,TNFSF10,TRIM21 | NA |
| CREBBP | 3.30e-01 | transcription regulator | Activated | 2.56e+00 | 0.0e+00 | AGT,AMPD1,ANGPT1,BDKRB2,BMP7,CCL5,CCND1,CDC42EP3,CDCP1,CDKN1A,CKB,CLASP2,COL2A1,CRISPLD2,CRYAA/LOC102724652,CXCL10,CXCR3,DHRS3,DUSP1,DUSP22,EDARADD,EGR2,EGR3,EPSTI1,FDX1,FMNL2,FUT7,GFRA1,GNRHR,GRIA3,GRIN1,GRIN2C,GRIN3B,HDAC11,HLA-G,HMGCS1,IL12RB1,IL17RE,INHA,IRF1,IRF6,JUN,JUP,MCM3,MSH2,NDRG1,NR4A2,NR4A3,PBX1,PCNA,PDE10A,PDE3B,PRKCD,RAPGEF3,RAPGEF4,REN,RNF39,RTP4,SCN4B,SDC1,SFTPB,SLC7A11,SREBF1,TBX4,TH,TLE2,TLE6,TLR2,TMEM38A,TMPRSS4,TNC,TNFSF10,TRAF1,USP18,WNT5B,XRCC6 | 719 (23) |
| corticosterone | NA | chemical - endogenous mammalian | Activated | 2.55e+00 | 4.0e-02 | ANGPTL4,BDKRB2,CAV1,CCND1,CDKN1A,CRISPLD2,DIO2,DOCK8,FGF7,GPAM,HSPA5,IDE,JUN,LEP,NMB,NOS1,PNPLA2,SCARB1,TGM2,TLR2,UCP2 | NA |
| IKZF1 | NA | transcription regulator | Activated | 2.54e+00 | 3.0e-02 | C1QTNF1,CAV1,CAV2,CDKN1A,CISH,CXCR3,DTX3L,DUSP5,EPOR,EPSTI1,FGF13,FLT3,FUT10,HK2,IFI16,IL15RA,ITGA2B,JUP,KIF16B,KLF4,MAP2,NLRP3,NR1H4,OPRD1,RAI14,RAPGEF4,RNF213,RTP4,RUBCN,SERPINH1,TBC1D9,TMEM119,UEVLD | NA |
| nelfinavir | NA | chemical drug | Activated | 2.53e+00 | 2.0e-02 | AKNA,ASNS,ATF4,CARS1,CHAC1,DGAT1,KLF4,MTHFD2,NFIL3,PLIN4,SLC7A11,STC2,TGM1 | NA |
| GNAS | 3.00e-01 | enzyme | Activated | 2.52e+00 | 0.0e+00 | ADAMTS1,CD200,CD55,CD86,CYP27B1,FCHSD2,GEM,GFOD1,GPRC5A,IFI16,INHA,ISY1-RAB43,KLF4,LEP,MAFF,NR4A2,NR4A3,PDE3B,PDE4A,PDE4B,PENK,PMEPA1,PRKCB,RAPGEF4,SCG3,STAT3,THBS1,TRIB1,TSC22D1,VGF,Zfp52 | 709 (20) |
| rolipram | NA | chemical drug | Activated | 2.52e+00 | 1.0e-02 | BCL2L11,CD86,DUSP1,IL1R2,NLRP3,PDE1A,PDE4B,PTPN1,SFTPB,TLR5 | NA |
| beta-estradiol | NA | chemical - endogenous mammalian | Activated | 2.47e+00 | 0.0e+00 | ABCB10,ABCC8,ABLIM1,ACE,ACKR3,ACTG1,ACTN4,ADAMTS1,ADAMTS4,ADGRF5,ADGRG2,ADORA1,ADRB3,AGER,AGT,AGXT2,AMZ1,ANGPT1,ANPEP,APBB1,AQP5,ARMT1,ARSB,ASIC4,ATAD2,ATM,ATP2B2,AURKA,BAMBI,BCAR1,BCAT1,BCL2L11,BCS1L,BHLHE40,BIN1,BOP1,C1orf226,C8orf44-SGK3/SGK3,CABP7,CAV1,CAV2,CCDC170,CCL5,CCND1,CCNE1,CD55,CD86,CDC25A,CDK18,CDKN1A,CDKN1C,CFTR,CGNL1,CHGB,CHRM1,CISH,CKB,CLCN3,CLDN4,CLDND1,CLEC4D,CLIC4,CLIC5,CNR1,COIL,COMP,CPM,Crabp2,CREB3L1,CRYAA/LOC102724652,CSE1L,CSF2RB,CSTB,CUL4A,CXCL10,CXCL11,Cxcl3,DDB2,DDR1,DGUOK,DLG2,DLL1,DSP,DUSP1,DUSP5,EFNB2,EGR2,EGR3,EIF3B,EIF3D,ELK3,EPAS1,EPHA5,EPOR,ESR1,ETV1,ETV6,EXT2,EZH2,F2R,FADS1,FAM107A,FARP1,FDFT1,FGF7,FGF9,FJX1,FLOT1,FLRT3,FMO1,FMO5,FOSL1,FSCN1,FXYD5,FZD7,GADD45A,GADD45B,GAL,GALNT7,Gar1,GCH1,GCHFR,GEM,GFRA1,GJA1,GLRB,GNL3,GNPTAB,GNRHR,GPAM,GPRC5A,GPRC5B,GRB10,GREB1,GREM1,GRIN1,GRIN2C,GTF2IRD1,GYG1,H6PD,HCRTR1,HCRTR2,HDAC1,HDAC11,HDAC4,HDAC5,HES6,HIVEP2,HMGCS1,HMMR,HNRNPA1,HNRNPD,HS1BP3,HSD17B7,HSPA2,HSPA5,HSPB8,HSPH1,HYAL3,ICAM1,ID3,ID4,IDE,IER3,Ifgga2l1/RGD1309362,IFI35,IL18,IL19,IL1R2,IL20,INHA,INHBB,INPP4B,INPP5J,IPO5,IRF1,IRF6,IRF7,ITGA11,ITGA2,ITGAV,JAK2,JUN,KAZN,KCNK5,KCTD19,KCTD6,KDELR2,KLF4,Klrk1,L1CAM,L3MBTL1,LAMB3,Ldha/RGD1562690,LEF1,LEP,LGR5,LIPC,LOX,LPCAT2,LTBP1,MAD2L1,MAGED1,MANBA,MAP2K3,MCM3,MCM4,MERTK,MGC116197 (includes others),MICAL2,MICOS10-NBL1/NBL1,MLH1,Mllt3,MPDZ,MPPED2,MRAP2,MSH2,Muc1,MX1,MYBL2,MYCN,MYO10,MYO5B,MYOF,NARF,NCOA2,NDRG1,NECTIN1,NEDD9,NET1,NFYA,NMB,NOP56,NOP58,NOS1,NPTXR,NR0B2,NR1H3,NR4A2,NR4A3,NRG1,NRIP3,Oasl2,OAZ1,OSBPL3,OXTR,P2RX5,P4HA1,PAK1,Pakap,PAQR7,PARP1,PATJ,PBX1,Pcdh10,PCNA,PDE1A,PDE3B,PDE4B,PDGFB,PDGFC,PDGFD,PDIA4,PDK2,PENK,PEX11A,PIBF1,PIK3R5,PLAT,PLK1,POLA1,POLE2,PPP1R3B,PPP2CB,PPP2R1B,PPP2R2B,PPRC1,PRC1,PRKCB,PRKCD,PRKX,PROCR,PROM1,PRSS35,PSD,PTBP2,PTGDR2,PTGFR,PTP4A1,PTPN1,PTPRN,PTPRU,RABEP2,RAD54L,RAPGEFL1,RBL2,RBM15B,RDX,REN,RET,RGS3,RGS7,RGS9,RLIM,RMND1,RND1,RNF128,RNF4,RORA,RPL9,RRM2,RTP4,S100G,SAP30,SATB1,SCARB1,SCG3,SCNN1A,SDC1,SERPINE1,SIM1,SKIL,SKP2,SLC12A5,SLC13A3,SLC14A1,SLC16A1,SLC22A8,SLC25A15,SLC31A1,SLC38A9,SLC39A7,SLC3A2,SLC45A1,SLC6A14,SLC6A17,SLC6A4,SLC7A5,Slco1a4,SLCO2A1,SMC2,SMPD1,SOCS1,SOCS2,SORD,SOX11,SPDEF,SRD5A1,SREBF1,SRP54,SSTR1,STAT1,STAT3,STBD1,STC2,SYTL4,TBC1D9,TFEB,TGFB2,TGFBR3,TGIF2,TGM2,TH,THBD,THBS1,TIAM1,TIMM8B,TIMP3,TK1,TLR2,TMEM120B,TMEM150C,TMEM164,TMEM44,TMPO,TNC,TNFRSF21,TRIB1,TRPM4,TRPV1,TSC22D1,TUBB4B,TXNRD1,TYK2,UBE2C,UBE2I,UNC5C,USP8,VAPA,VCAN,VCL,VDR,VEGFC,VGF,WNT5A,WNT5B,XPA,XPO1,ZBTB2,ZBTB42,ZMYM3,ZNF846 | 934 (21) |
| gentamicin | NA | chemical drug | Activated | 2.45e+00 | 0.0e+00 | ACSL3,AK1,ARF6,BMP7,BTG3,CCND1,CHORDC1,CSRP2,CXCL10,DDX39A,EAF1,EIF3B,EIF3D,FMO1,FXYD5,GADD45A,GFER,GNL3,HIVEP2,HSPA1A/HSPA1B,HSPA5,ICAM1,IDH1,IRF1,IRF7,JUN,L3HYPDH,LOC102549726,NCL,NOP58,NR1D1,NRG1,PDIA4,PIK3R4,PPP1R10,PTBP1,PTP4A1,PTPN1,RBBP9,RNF4,S100G,SLC9A3,SOCS2,STAT3,TFRC,TMEM120A,TSC22D1 | 525 (13) |
| NPM1 | 4.20e-01 | transcription regulator | Activated | 2.45e+00 | 0.0e+00 | BAMBI,CEACAM1,CYP27B1,DDB2,DLL1,EGR3,FAM110C,GEM,GJA1,HSPA5,ICAM1,ITGAV,JUN,KLF4,LAMC2,LOX,NAV3,NR1D1,P3H2,PDGFB,PMEPA1,RELT,TRIB1,VEGFC,WNT5A | 650 (22) |
| UBE2I | 9.10e-01 | enzyme | Activated | 2.45e+00 | 1.0e-02 | CCND1,CXCL10,IRF1,NR0B2,PML,PRDM16,SCNN1A,STAT1 | NA |
| P2RY14 | -9.50e-01 | G-protein coupled receptor | Activated | 2.45e+00 | 7.0e-02 | BAD,GAL,GHRL,GLP1R,PLCH1,SSTR1 | NA |
| ISLR | -3.80e-01 | other | Activated | 2.45e+00 | 1.0e-01 | ERCC6L,FZD1,NF2,SLC7A11,SOX11,TEAD3 | NA |
| OLFM4-RET | NA | fusion gene/product | Activated | 2.45e+00 | 1.0e+00 | EGR2,EGR3,FOSL1,SERPINB2,TCERG1L,TMPRSS4 | NA |
| Wy 40905 | NA | chemical reagent | Activated | 2.45e+00 | 0.0e+00 | ACE,BBS9,CDKN1A,EGR2,FANCC,FOSL1,FXYD5,GADD45B,GNRHR,JUN,KLF4,RFX2,SERPINE1,SKIL,SLC6A4 | 696 (23) |
| MAP2K1 | 3.40e-01 | kinase | Activated | 2.44e+00 | 0.0e+00 | AXIN2,BAD,BCL2L11,BIRC2,CCL5,CCND1,CDKN1A,DUSP1,DUSP5,EGR2,F2R,FOSL1,GADD45B,GPRC5B,GRIN1,HSPA5,IER3,ITGA2B,ITGA5,JUN,JUP,LEF1,LEP,MYCN,NET1,NOS1,PCNA,RRM2,SCARB1,SPDEF,TGM2,THBD,THBS1,TK1,TNC,TNFRSF10A,TNFSF10,TRIB1,ZWINT | 756 (21) |
| EDN1 | 5.10e-01 | cytokine | Activated | 2.44e+00 | 0.0e+00 | ARF6,ATP2A2,CCND1,CDC25A,COMP,FOSL1,GJA1,HSPA5,ICAM1,IL18,ITGA2,ITGA5,ITGAV,JUN,LEP,MARCKSL1,NRG1,OLR1,PRKCB,PRKCD,REN,SDC1,SERPINB2,SERPINE1,SKP2,SOCS1,TGM2,THBS1,TIMP3,TNC,TPT1,VCAN,VCL,VEGFC | 895 (19) |
| ICAM1 | 5.90e-01 | transmembrane receptor | Activated | 2.42e+00 | 3.5e-01 | CCL5,CD86,ICAM1,KLF4,PROM1,SREBF1 | NA |
| pyruvaldehyde | NA | chemical - endogenous mammalian | Activated | 2.41e+00 | 4.0e-02 | AGER,CDKN1A,CRYAA/LOC102724652,CRYBA1,ICAM1,NQO1,OLR1 | NA |
| ciglitazone | NA | chemical drug | Activated | 2.40e+00 | 5.0e-02 | AGT,AQP3,BRIX1,CAV1,CAV2,CCL5,CCND1,CDKN1A,ESR1,GAL,ICAM1,NFKBIB,OLR1,PARP1,SERPINE1,TGM1,TH,TNFSF10 | NA |
| SUMO3 | 2.00e-01 | other | Activated | 2.40e+00 | 0.0e+00 | AGT,CAV1,CAV2,CEACAM1,CXCL10,GRB14,HLA-G,HMGA1,Ifgga2l1/RGD1309362,PML,TNC,TNFRSF21 | 529 (13) |
| MAPK14 | 1.20e-01 | kinase | Activated | 2.39e+00 | 1.8e-01 | AXIN2,CCL5,CCND1,CD83,CD86,CXCL10,DLL1,DUSP1,GADD45A,GJA1,GREM1,ICAM1,IL18,JUN,LEF1,NFATC1,SH2D2A,SREBF1,TGM2,TLR2,TRPV1,VDR,VEGFC | NA |
| diethylmaleate | NA | chemical toxicant | Activated | 2.39e+00 | 0.0e+00 | BIRC2,CDKN1A,NQO1,SLC3A2,SLC7A11,SREBF1 | 667 (18) |
| MPT0B291 | NA | chemical reagent | Activated | 2.37e+00 | 0.0e+00 | APEX2,CHEK2,DDB2,EME1,FANCC,FANCG,GEN1,HMMR,PCNA,RAD51,RAD54L,TMPO | NA |
| simvastatin | NA | chemical drug | Activated | 2.36e+00 | 4.4e-01 | ADAMTS1,CCND1,CD55,CDKN1A,ESR1,F2R,FADS1,GJA1,ICAM1,IL18,IRF1,KLF4,NFATC1,OLR1,PLAT,SCARB1,SERPINE1,STAT1,THBD,TLR2 | NA |
| CITED2 | -5.30e-01 | transcription regulator | Activated | 2.35e+00 | 0.0e+00 | ANGPTL4,CD86,CLEC10A,CLIC5,CXCL10,DTX3L,DUSP1,EXT1,FMNL2,GADD45B,GBP4,GBP5,HOPX,ICAM1,IFI16,IFI35,IFI44,Ifi47,IFIH1,IRF1,IRF9,Irgm1,Klrk1,MTMR14,Oasl2,P2RY14,PARP14,PARP9,PDGFC,RTP4,SERPINB2,TGM2,TRIM6-TRIM34,TTC39B,UPP1,Zfp658 | 528 (14) |
| CG | NA | complex | Activated | 2.35e+00 | 0.0e+00 | ADAMTS1,ADAMTS4,Akr1b7,ANGPTL4,APLNR,APPL2,ATF4,AXIN2,BAMBI,BCAT1,BHLHE40,BLM,BTG3,CCDC86,CCND1,CDK19,CDKN1A,CPM,CRISPLD2,CX3CL1,CXCL10,DUSP1,EFNB2,EIF4E,ELK3,EPAS1,EPHB6,EPSTI1,ETV1,FAM110C,FGF12,FGF7,FGF9,FJX1,FOSL1,FZD1,GADD45B,GAL,GAS1,GHRL,GJA1,GNA15,GNRHR,GREM1,HK2,HMGA1,HMGCS1,HSD17B7,ICAM1,IER3,IFI16,IL15RA,IL18,IL1R2,IL20,IL33,INHA,INHBB,ITGA2,ITGAV,JUN,KLF4,LSS,MAP2K5,MAPKAPK2,MCM3,MMP19,NFKBIB,NR0B2,Oasl2,OXTR,PCNA,PDE4D,PDGFC,PKIA,PLAT,PLPP3,PLXND1,POLE2,PRKX,PRRG1,PTGFR,PUS3,RAB11FIP3,RORA,SCARB1,SDC1,SEMA3E,SLC5A7,SLCO2A1,SMARCA1,SPAG1,SREBF1,TDRD5,TGFB2,TGFBR3,TMEM164,TNFRSF21,TRIB1,TTC39B,UPP1,VCAN,VEGFC | 855 (16) |
| EML4-ALK | NA | fusion gene/product | Activated | 2.35e+00 | 0.0e+00 | BCL2L11,CDKN1A,DUSP1,ERCC5,FGF13,GADD45B,IL15RA,IRF1,MAP3K13,PDGFC,PTP4A1,SERPINE1,STAT3,THBD,TLR2,VCAN | 583 (17) |
| cisplatin | NA | chemical drug | Activated | 2.35e+00 | 0.0e+00 | ABCB10,ABCC4,ADAMTS1,AGXT2,ANPEP,AQP3,ASCC1,ASNS,ATF4,ATXN1,BBS9,BCL2L11,Bex2/LOC100912195,BIRC2,Casp12,CAV1,CCL5,CCND1,CDC25A,CDCP1,CDKN1A,CDKN1C,CHEK2,CLDN4,Ctla2a,CXCL10,DDB2,DHRS3,DMXL2,DPYSL5,DUSP1,EEF2K,ESR1,EZH2,F11R,FLRT3,FOSL1,FXYD5,GADD45A,GAS1,GML,GTPBP4,HK2,HMGCS1,HSPA5,ICAM1,IER3,IFIH1,IL18,INMT,JUN,KCNK5,L1CAM,LAMB3,LAMC2,LGR5,LILRB4,LIPC,MAD1L1,MCM3,MICALL2,MLF1,MSH2,Mt1,MX1,MYCN,NAV3,NQO1,NR0B2,NR1H4,PARP1,PAWR,PCNX2,PDE3B,PDE4A,PHLDA3,PLA1A,PLAT,PLEKHM1,PLK1,PRDM5,PRKDC,PROCR,PROM1,PTPRO,RAD51,RBM3,RRM2,RRP1B,SCN4B,SERPINE1,SLC15A2,SLC22A8,SLC31A1,SLC6A4,SMPD1,SPON2,STAT3,THBS1,TIMP3,TLE4,TLR3,TNC,TNFSF10,TRPV1,TSC22D1,TSPAN8,UCP2,UPP1,VDR,XRCC6,YBX1 | 825 (24) |
| CLU | 1.20e-01 | other | Activated | 2.35e+00 | 2.0e-02 | CCND1,CDKN1A,GBP5,HSPA1A/HSPA1B,HSPA5,LARS2,NFKBIB,PARP14,SREBF1,STAT1 | NA |
| sulforafan | NA | chemical drug | Activated | 2.34e+00 | 3.0e-02 | ADAMTS1,AGT,AKR1B1,Akr1b7,CCND1,CDKN1A,EFNB2,FBXL4,FTL,Fus,GOLGA4,GSTT2/GSTT2B,HDAC1,ICAM1,MED31,MICAL3,Mt1,NDST1,NQO1,NR0B2,PDK2,PHKA1,PML,SLC6A4,TGFB2,TIMP3,TK1,TMEM178A,TXNRD1,UBA2,USP18,WIPI2 | NA |
| TAS4464 | NA | chemical drug | Activated | 2.33e+00 | 0.0e+00 | ATF4,CDC25A,CDKN1A,GADD45A,ITGAX,LAMB3,PLK1,SLC3A2,SLC7A5 | 564 (12) |
| TET2 | -1.20e-01 | enzyme | Activated | 2.32e+00 | 3.5e-01 | ATP4A,BCL2L11,BCL3,BHLHE40,CLEC4D,IFI16,ITGA2,ITGAX,LILRB4,MAFF,S100G,SLC6A4,SPINT1,TBX6,TGM1 | NA |
| phenylbutazone | NA | chemical drug | Activated | 2.32e+00 | 0.0e+00 | ADAMTS1,ASNS,Bex2/LOC100912195,CCND1,CDCP1,CLDN4,Ctla2a,FXYD5,GTPBP4,IER3,LAMC2,MCM3,PLA1A,RBM3,TSPAN8,UPP1 | NA |
| mitomycin C | NA | chemical drug | Activated | 2.30e+00 | 1.0e-02 | ATP23,BCL2L11,CCND1,CDC25A,CDKN1A,GADD45A,HSPA5,IRF2BP2,IRF2BPL,JUN,NQO1,PARP2 | NA |
| allopurinol | NA | chemical drug | Activated | 2.30e+00 | 0.0e+00 | ADAMTS1,ASNS,Bex2/LOC100912195,CDCP1,CLDN4,Ctla2a,CXCL10,FXYD5,GTPBP4,IER3,IRAK4,LAMC2,MCM3,PLA1A,RBM3,REN,SLC9A3,TSPAN8,UPP1 | 446 (7) |
| NLRP3 | -8.10e-01 | other | Activated | 2.29e+00 | 0.0e+00 | ATF1,ATM,CCL24,CCL5,Cd209d,CEBPZ,CXCL10,Cxcl3,CXCR3,DDB2,GSDMD,IL18,IL33,IRF1,IRF7,NLRP3,OGG1,OLR1,PARP1,PARP2,PRIM2,PRKDC,RAD51,STAT1,STAT3,TDP1 | 536 (17) |
| Am 580 | NA | chemical reagent | Activated | 2.27e+00 | 0.0e+00 | CNR1,DUSP1,FDFT1,HMGCS1,IRF1,LRAT,LSS,MYCN,PLAT,RAI14,TGM2,THBD | 594 (12) |
| methylprednisolone | NA | chemical drug | Activated | 2.27e+00 | 0.0e+00 | AHCY,ANPEP,ARSB,ASNS,ATP2A2,ATP4A,B4GALNT1,BAIAP2,CCND1,CDKN1A,CYB5B,Cyp3a25 (includes others),DUSP1,EIF3B,ELOVL5,FABP7,FBXO32,FDFT1,FGF7,FGR,GADD45A,GCH1,GCHFR,GNL3,GSTT2/GSTT2B,HAGH,HMBS,HSD3B7,HSPA1A/HSPA1B,HSPH1,ID3,IDH1,IGFALS,IRF1,IRF7,ITGA2,ITGA5,JAK2,JUN,JUP,LOX,Mt1,NCL,NFIA,NR0B2,NR1H3,NR1H4,PAQR7,PCNA,PDE3B,PEX11A,PIK3AP1,PIM3,PKIA,PKP1,PLA1A,PLAT,PNRC1,POR,PPM1G,PRMT1,PTPN1,RAPGEF4,RBL2,RNF4,SCLY,SDC1,SEPHS2,SERPINE1,SLC12A5,SLC13A3,SLC16A1,SLC26A1,SLC30A1,SLC9A3,SLCO2A1,SORD,STAT1,STAT3,TFRC,TIMP3,TINAGL1,TLR2,TLR3,TLR5,TNIP1,TOMM20,TUBA1C,UCP3,UGCG | 755 (19) |
| DUSP11 | -1.30e-01 | phosphatase | Activated | 2.24e+00 | 3.0e-02 | IFI44,IRF7,Oasl2,SLFN13,USP18 | NA |
| HCAR1 | -8.80e-01 | G-protein coupled receptor | Activated | 2.24e+00 | 3.0e-02 | HK2,ICAM1,NEDD9,SLC16A1,TGFB2 | NA |
| xanthohumol | NA | chemical drug | Activated | 2.24e+00 | 9.0e-02 | BIRC2,CCND1,ICAM1,NFATC1,NQO1,SREBF1 | NA |
| interferon alfacon-1 | NA | biologic drug | Activated | 2.24e+00 | 1.7e-01 | IL1R2,MAFF,PARP14,PBX1,XPO1 | NA |
| sulindac sulfide | NA | chemical drug | Activated | 2.23e+00 | 0.0e+00 | ATF4,BAD,CCND1,CDKN1A,CYB5B,GADD45A,HSPA5,MAD2L1,MTHFD2,NQO1,NRG1,RRS1,STAT3,STC2,XRCC6 | 679 (20) |
| EIF2AK3 | 5.60e-01 | kinase | Activated | 2.22e+00 | 0.0e+00 | Arf2,ARF4,ASNS,ATF4,ATP2A2,BCL2L11,BIRC2,CA9,CARS1,CCND1,CLCN3,CPOX,ECD,EPRS1,FOSL1,GADD45A,GCH1,GOLGA4,GOLT1B,HSPA5,JUN,KDELR2,KLF4,NDRG1,NFIL3,SEC61A1,SLC1A7,SPATA5 | 634 (20) |
| SUMO1 | -7.00e-02 | enzyme | Activated | 2.22e+00 | 9.0e-02 | ATP2A2,CCND1,CIDEC,CXCL10,DDX39A,NR0B2 | NA |
| H2AZ1 | NA | other | Activated | 2.22e+00 | 2.9e-01 | CCND1,CDKN1A,MYBL2,NUP62,PLK1,SLC23A2 | NA |
| COMMD3-BMI1 | -1.00e-02 | transcription regulator | Activated | 2.22e+00 | 3.3e-01 | CCNE1,HOXB6,HOXB7,LEF1,WNT5A | NA |
| CL 316243 | NA | chemical drug | Activated | 2.21e+00 | 1.3e-01 | CKB,ITGAX,NQO1,PRDM16,UCP2,UCP3 | NA |
| triamterene | NA | chemical drug | Activated | 2.21e+00 | 0.0e+00 | ADAMTS1,ASNS,Bex2/LOC100912195,CDCP1,CLDN4,Ctla2a,FXYD5,GTPBP4,IER3,LAMC2,MCM3,PLA1A,RBM3,TSPAN8,UPP1 | NA |
| cyclic AMP | NA | chemical - endogenous mammalian | Activated | 2.21e+00 | 1.0e-02 | AFAP1L2,Akr1b7,CCND1,CD86,CDC25A,CDKN1A,EGR2,GCH1,GJA1,GNRHR,IL33,INHA,JUN,LEP,NFATC1,NOS1,NR4A2,OPRD1,PAH,PDE4B,PDE4D,PENK,RAPGEF3,REN,SCARB1,SERPINB2,SERPINE1,SREBF1,STAT1,STAT3,TH,THBD,TK1,TNFSF10,VGF | 822 (21) |
| NGF | 5.90e-01 | growth factor | Activated | 2.20e+00 | 0.0e+00 | AGL,ASIC1,ATM,AXIN2,BAMBI,BCL2L11,CAV1,CAV2,CCND1,CD83,CD86,CDKN1A,CHGB,DPYSL5,DUSP1,EGR2,EHD4,EPAS1,FOSL1,GADD45A,GAL,GCH1,GRIN1,ID3,IER3,ITGA2,JUN,KLF4,MAFK,MAP2,MYCN,NOS1,OPRD1,PARP1,PPP2R2B,RBL2,REN,RET,STAT3,TH,TRPV1,UNC5C,VEGFC,VGF,WNT5A,ZWINT | 862 (20) |
| SOX6 | 1.10e-01 | transcription regulator | Activated | 2.20e+00 | 7.0e-02 | Acan,CCND1,CDKN1A,COL2A1,MYH7B | NA |
| Pro-inflammatory Cytokine | NA | group | Activated | 2.20e+00 | 7.0e-02 | AKR1B1,CD55,HSPA5,ICAM1,LIPG,NR1H4,OLR1,SLC6A4,SPINT1,TLR2 | NA |
| NGLY1 | -1.12e+00 | enzyme | Activated | 2.20e+00 | 1.9e-01 | CXCL10,IFI44,IFI44L,USP18,WIPI2 | NA |
| HSPG2 | NA | enzyme | Activated | 2.20e+00 | 1.9e-01 | Acan,COL2A1,EPG5,GADD45A,MAP1LC3A | NA |
| GADD45G | 4.00e-01 | other | Activated | 2.19e+00 | 0.0e+00 | CCNE1,CDKN1A,NPTX2,RAD51,TGFB2 | 681 (21) |
| 2-bromoethylamine | NA | chemical reagent | Activated | 2.19e+00 | 0.0e+00 | ADAMTS1,CLDN4,Ctla2a,FXYD5,IER3,LAMC2,MCM3,PLA1A,RBM3,TSPAN8,UPP1 | NA |
| vitamin K3 | NA | chemical drug | Activated | 2.19e+00 | 1.4e-01 | ATF4,CHRNA9,HK2,HSPA5,PPRC1 | NA |
| IL1RN | 1.10e-01 | cytokine | Activated | 2.19e+00 | 0.0e+00 | CDKN1A,CHAC1,CXCL11,GBP1,GJA1,GSDMD,H6PD,ICAM1,IFI44,IFI44L,IFIH1,IRF1,IRF7,IRF9,ISG20,L1CAM,MX1,NR0B2,OAS2,PML,RTP4,SERPINE1,SLC6A4,STAT2,TNFSF10,USP18,VEGFC,ZNF81 | 700 (18) |
| tunicamycin | NA | chemical - endogenous non-mammalian | Activated | 2.18e+00 | 0.0e+00 | Acan,ADAM10,Arf2,ARF4,ASNS,ATF4,ATP2A2,BIRC2,Casp12,CCND1,CDKN1A,CHAC1,COL2A1,DGAT1,ECD,EDEM2,GADD45A,GADD45B,GNAT2,GOLGA4,GOLT1B,HOOK1,HSPA5,ICAM1,KDELR2,KLF4,LGR5,NDRG1,NFATC1,NFIL3,NR1H3,PCNA,PROM1,RRS1,SDC1,SEC61A1,SKP2,SLC25A28,SLC7A11,SREBF1,TLR2,TNFRSF10A | 631 (20) |
| mevastatin | NA | chemical drug | Activated | 2.18e+00 | 1.0e-02 | ADAMTS1,CDKN1A,KLF4,NOS1,SREBF1 | NA |
| tosedostat | NA | chemical drug | Activated | 2.18e+00 | 0.0e+00 | ASNS,CARS1,CDKN1A,CHAC1,CLEC7A,GADD45A,SDC1,SLC7A11,STC2 | NA |
| MAFB | -1.40e-01 | transcription regulator | Activated | 2.17e+00 | 4.5e-01 | EGR2,ESR1,F2RL3,ITGA2B,LARS2,NFATC1,NPHS2,OLFML2B,OSCAR,SERPINB2,TMEM119 | NA |
| CDK2 | -2.00e-01 | kinase | Activated | 2.16e+00 | 1.0e-02 | BCL2L11,CCNE1,CDC25A,CDKN1A,MAP2,MYBL2,PCNA,RBL2,UCP2 | NA |
| TCR | NA | complex | Activated | 2.13e+00 | 0.0e+00 | ABCD1,ABLIM1,ARPP21,BCAT1,BCL2L11,BCL3,BIN1,CCL5,CCND1,CCNE1,CD200,CISH,CXCL10,CXCL11,CXCR3,DHX58,EGR2,EIF4E,GADD45B,Gar1,GBP4,GNPDA1,GRIA3,HSPA5,ID3,IFI44,IFI44L,IFIH1,IL12RB1,IRF1,IRF7,ISG20,JUN,KCNK5,LAT,MX1,MYCN,NFATC1,NIP7,NOP58,PDE3B,PDIA4,PRKACB,PRMT1,RNF128,RPL9,RRS1,SKIL,SOCS1,SOCS2,SOX12,STAT1,STAT3,TLR3,TSC22D1,VDR,ZNFX1 | 647 (20) |
| PRDM16 | -1.06e+00 | transcription regulator | Activated | 2.13e+00 | 0.0e+00 | AGT,CCL5,CDKN1A,CXCL10,DIO2,GBP4,IFI44,IRF7,OAS2,PPRC1,SERPINE1,STAT1,STAT2 | 512 (24) |
| methapyrilene | NA | chemical drug | Activated | 2.12e+00 | 2.0e-01 | ACTG1,ATF4,CCND1,GADD45A,GFRA1,GRB14,HSPA5,IGFALS,LIPC,Mt1,NR1H4,NSFL1C,PRKCB,SLC3A2,TXNRD1 | NA |
| pirinixic acid | NA | chemical toxicant | Activated | 2.12e+00 | 2.9e-01 | ACAT2,ANGPTL4,AP3M1,APOC2,AQP3,ASNS,BMP7,CCL5,CCND1,CCNE1,CD200,CDKN1A,CEACAM1,CIDEC,ELOVL5,FADS1,FBXO32,GADD45A,GADD45B,GPAM,HMGCS1,LAMB3,Ldha/RGD1562690,LEP,LY6D,MPDZ,MYBL2,NR1D1,NR1H3,PCNA,PEX11A,PLIN4,POR,RORA,RPIA,SERPINE1,SREBF1,ST3GAL5,TIAM1,TRIM63,UCP2,UCP3 | NA |
| STAT6 | -4.40e-01 | transcription regulator | Activated | 2.12e+00 | 0.0e+00 | ABLIM1,ADAM11,BCL3,BIRC2,CCDC86,CCL24,CCL5,Ccl6,CDKN1A,CIDEC,CISH,CPOX,CXCL10,CYB561A3,DHX58,EGR2,EXT1,FADS1,FSCN1,FYCO1,GADD45B,GBP5,Gm12854/S100a11,GNA15,GSDMC,IFI16,IFI44,IFI44L,IFIH1,Igtp,IL33,IRF1,IRF7,IRF9,Irgm1,ISG20,JAK2,LACC1,LILRB4,LY6D,MAP3K5,MOV10,NEDD9,NFATC1,NFIL3,NMD3,PCYOX1L,PDGFC,PIANP,PLSCR1,PNPLA2,POLE2,PPP3CC,PTGDR2,RAB30,RNF213,SAMD4A,Scd2,SERPINE1,SOCS1,SOCS2,SPDEF,STAT2,TIMP3 | 735 (17) |
| fenamic acid | NA | chemical reagent | Activated | 2.12e+00 | 0.0e+00 | ADAMTS1,ASNS,Bex2/LOC100912195,CDCP1,CLDN4,Ctla2a,FXYD5,GTPBP4,IER3,LAMC2,MCM3,PLA1A,RBM3,TSPAN8,UPP1 | NA |
| JQ1 | NA | chemical reagent | Activated | 2.12e+00 | 1.0e-02 | BCL2L11,CCND1,CDCP1,CFTR,CISH,CLEC10A,FDFT1,HSPA5,LAMB3,LRRC49,MAPKAPK2,MCM3,MX1,MYCN,Oasl2,P2RY14,RAD51,RRM2,SLC7A11,STAT3,TLR2,TNFSF10,TRAF1 | NA |
| tetrabromobisphenol A | NA | chemical toxicant | Activated | 2.11e+00 | 1.0e-02 | BMP7,GREM1,ITGA2,JUN,LOX,LTBP1,PDGFB,SERPINH1,TGFB2,THBS1,TIMP3 | 691 (24) |
| NGEF | 3.70e-01 | other | Activated | 2.11e+00 | 1.1e-01 | COL2A1,ERC2,GBP1,IFI44L,KCNJ8,MX1,NR0B2,PARP3,PTPRU,RAPGEF4,TNFSF10 | NA |
| BCR (complex) | NA | complex | Activated | 2.11e+00 | 3.0e-02 | AFMID,ARAP2,ASNS,ATP6V1E1,BCL2L11,BCL3,CCND1,CD86,CDC25A,CDKN1A,EGR2,ELOVL5,GNL3,HK2,HSPA5,ICAM1,IL12RB1,IL1R2,IRF7,JAK2,KLF4,MCM4,MPHOSPH10,NIP7,PPRC1,RHOF,RRP12,SEMA4B,SLC38A1,SORD,STAT1,TBRG4,TNIP1,TRIB1,WDR43,ZMIZ1 | NA |
| NKX2-1 | 6.00e-01 | transcription regulator | Activated | 2.10e+00 | 0.0e+00 | ADGRF5,AGER,AGT,AQP5,BTG3,CLDN18,DIO2,IER3,INMT,LEF1,LRP2,MATN4,NOP56,RAD51,RBPJL,RET,RRM2,S100G,SATB1,SCGB3A2,SCNN1G,Serpinb6b,SERPINE1,SFTPB,SFTPC,SLC6A14,TGFB2,THBS1,TNC,WNT5B | NA |
| indole-3-carbinol | NA | chemical drug | Activated | 2.10e+00 | 1.0e-02 | CCND1,CDKN1A,ESR1,FMO1,LCP1,SFTPC,Slco1a4,TRAF1 | 534 (12) |
| vorinostat | NA | chemical drug | Activated | 2.08e+00 | 0.0e+00 | ADAMTS1,ATG7,AURKA,B3GALT1,BAD,BCL2L11,BIRC2,BRAF,CCND1,CDKN1A,CISH,CYP27B1,DUSP1,HDAC1,HMGCS1,HSPA5,ICAM1,IRF1,JUN,KLF4,LIPG,LSS,MED26,mir-154,MLH1,MMP15,MYBL2,NDRG1,OSBPL3,PARP1,PDGFB,PLIN4,RAD51,RAD52,RAD54L,SOCS1,SREBF1,ST3GAL5,TNFRSF10A,TNFSF10,TRADD,TRAF1,VEGFC | 786 (22) |
| thioacetamide | NA | chemical toxicant | Activated | 2.07e+00 | 0.0e+00 | ABCC4,ADAMTS1,ASNS,ATM,Bex2/LOC100912195,BHLHE40,BLM,CD200,CD55,CDCP1,CDH17,CIDEC,CKB,CLDN4,CSRP2,Ctla2a,ELMOD3,ELN,F2R,GDE1,GTPBP4,GYG1,IER3,JUN,LAMC2,LOX,LRAT,LTBP1,MCM3,MSH2,PCSK6,PDGFB,PDGFD,PLA1A,PLPP3,POLE2,POR,PRMT1,PROM1,PTGFRN,RBM3,Scd2,SLC13A3,SLC7A11,STEAP3,TGM2,TMC5,TSPAN8,UBLCP1,UPP1,WNT5A | 754 (13) |
| 1,25-dihydroxyvitamin D | NA | chemical drug | Activated | 2.06e+00 | 0.0e+00 | ATM,BCAT1,CCND1,LEP,REN,SLC7A5,SOCS1,STAT3,Tlr12,TLR2,TLR3,TLR5,VDR | 559 (13) |
| Lh | NA | complex | Activated | 2.06e+00 | 0.0e+00 | ADAMTS1,ATP2A2,BAD,CD55,CDKN1C,COL18A1,DHRS3,DUSP1,DUSP14,DUSP9,FDX1,GADD45B,GBP1,GEM,GJA1,GNRHR,GPRC5B,HK2,HSD17B7,INHA,INHBB,JUN,MAP2K3,MAP3K5,MBD2,MMP19,PAWR,PDE4D,PDLIM3,PIM3,PLAT,PLIN3,POP5,PRKX,PTP4A1,PTPN1,PTPRN,RAPGEF3,RGS7,RPL9,RPS18,SCARB1,SLC10A4,SLC38A1,SLC7A11,STAT1,STK24,TEX15,TGFB2,THBS1,TK1,TRIB1,UPP1,VCL,VEGFC | 907 (22) |
| RAF1 | 2.90e-01 | kinase | Activated | 2.06e+00 | 0.0e+00 | ACAT2,AMD1,ATP6V1B1,BCL2L11,CCND1,CDC25A,CDKN1A,CSTF1,DHRS3,DIO2,DUSP5,EGR3,ESR1,GNRHR,ID3,IER3,ITGA2,JUN,MYBL2,NOP56,NQO1,OSMR,PCSK6,PLAT,PPP1R10,RET,RFFL,RRM2,RTCB,SCNN1A,SDC1,SERPINB2,TGM2,TIAM1,TRAF1,TSC22D1,TUBB2A,VASH1 | 691 (22) |
| Cdk | NA | group | Activated | 2.06e+00 | 1.0e-02 | CCL5,CXCL10,DUSP1,GADD45A,ING1,MYCN,NEDD9,UCP2 | 618 (20) |
| SP3 | 1.60e-01 | transcription regulator | Activated | 2.06e+00 | 0.0e+00 | ASNS,CCND1,CDKN1A,CEACAM1,COL2A1,DUSP1,ESR1,F2R,FDX1,FOSL1,GLTP,GRIN1,HDAC4,HSPA5,ITGA2,JUN,KLF4,MYCN,NOS1,NPTXR,OPRD1,PRKCD,PROCR,PTPN1,SCARB1,SERPINE1,SERPINH1,SLC9A3,SREBF1,STAT1,STAT3,TCEAL1,TGFBR3,TGM1,TLR2,TNC,TXNRD1 | 727 (23) |
| IL1 | NA | group | Activated | 2.05e+00 | 1.0e-02 | ADAMTS1,ADAMTS4,BHLHE40,CCL5,CD55,CDKN1A,CEACAM1,CLEC7A,COL2A1,CSF2RB,CXCL10,CXCL11,DUSP1,F2RL3,FGF7,GJA1,GNRHR,ICAM1,IL1R2,IL33,IRF1,JUN,LEP,LIPC,LOX,LRAT,MAP2K3,NR1H3,NR1H4,NRG1,RORA,SERPINB2,SERPINE1,SFTPB,SFTPC,SREBF1,TGM2,THBD,TLR2,TNC,TNFSF10,UGCG,VCAN,WNT5A | 790 (20) |
| PTP4A1 | 7.90e-01 | phosphatase | Activated | 2.04e+00 | 1.3e-01 | ACTN4,AHCY,CCL5,DNAJB1,EIF6,GMPS,HSPA1A/HSPA1B,IFI16,MAP3K5,NOP56,PCNA,TMEM267,TUBA1C,VCAN | NA |
| IL6 | NA | cytokine | Activated | 2.04e+00 | 0.0e+00 | ADAMTS1,ADAMTS4,AGL,AGT,ANGPT1,ANPEP,ATP2A2,AXIN2,BAMBI,BCL2L11,BCL3,CCL24,CCL5,CCND1,CCNE1,CD83,CD86,CDKN1A,CEACAM1,CISH,CLEC10A,COL2A1,COMP,CSF2RB,CUL4A,CXCL10,CXCR3,DPP3,DUSP1,E2F4,EGR2,EPOR,EZH2,FOSL1,FSCN1,GADD45A,GADD45B,GAL,GCH1,GLRX,GREM1,GRIN1,HSPA5,ICAM1,IFI16,IL20,IRF1,IRF9,ITGAV,JAK2,JUN,LEP,MAD2L1,MAP2,MCM3,MERTK,MRAS,MSS51,Mt1,Mt1m/Mt2A,MYBL2,MYCN,NR1H4,OXTR,PCNA,PDGFB,PENK,PLAT,POLD1,PPRC1,PROM1,PTGFR,RASSF1,RET,RORA,RRM2,SCNN1A,SEMA4A,SENP2,SERPINE1,SFTPB,SLC14A1,SLC7A7,Slco1a4,SOCS1,SOCS2,SP110,STAP2,STAT1,STAT3,SV2B,TBC1D9,TFRC,TGM2,TH,THBS1,TK1,TLR2,TLR3,TLR5,TNC,TNFSF10,TYK2,UBE2C,WNT5A | 890 (18) |
| PPP3R1 | 2.10e-01 | phosphatase | Activated | 2.04e+00 | 0.0e+00 | ACTR3B,AQP5,ARID3A,ATP2A2,BCL3,CDH17,CLIC5,LRP2,Scd2,SCNN1G,SFTPB,SFTPC,SLC12A5 | 308 (7) |
| PDGF BB | NA | complex | Activated | 2.03e+00 | 0.0e+00 | ACAT2,ACKR3,ADRA1D,ANXA11,ASIC1,ATP2A2,BCL3,BDKRB2,BHLHE40,CAV2,CCND1,CCNE1,CDKN1A,COL18A1,CSRP2,DGAT1,DUSP1,DUSP5,EGR2,EGR3,FGF7,FMO1,FOSL1,FXYD5,FZD1,GADD45A,GEM,GJA1,GREM1,HDAC4,HMGCS1,HSD3B7,ID3,IER3,ITGA5,JUN,MAFK,MAP2,MICOS10-NBL1/NBL1,Mt1,MYBL2,NFIL3,NOS1,NR1H3,NR4A2,NR4A3,OLR1,PAWR,PCNA,PLAT,PRSS35,Scd2,SERPINE1,SKIL,SKP2,SLC6A4,SLC7A7,SREBF1,STAT3,TGM2,TH,THBD,THBS1,TNC,TRIB1,VCAN | 760 (19) |
| LMNA | 1.10e-01 | other | Activated | 2.02e+00 | 1.0e-02 | ABCC8,ADAMTS10,BAMBI,C8orf48,CCP110,ELN,ERCC5,FAM13C,GJA1,GSTT2/GSTT2B,HEATR5A,HMGA1,ID3,IFI44,IFIH1,IRF1,Irgm1,ISG20,JUN,LEP,MAFF,MMP15,PLD2,PNPLA2,PPCDC,SKAP2,SLC25A42,SLX4IP,SMARCA2,SREBF1,STAT1,SYNE2,TEC,TH,THUMPD3,TIMP3,TMEM164,TMPO,TOMM20 | 746 (23) |
| ETV6-RUNX1 | NA | fusion gene/product | Activated | 2.02e+00 | 0.0e+00 | ABLIM1,ARHGAP18,ARHGEF10,AURKA,BCL3,CALN1,CARD11,CCL5,CD83,CDC42EP2,CDC42EP3,DLL1,EIF4A1,FSCN2,GCH1,GMPR,GNA15,GREB1,ICAM1,IER3,IFI16,IFI35,IFIH1,IL15RA,IRF1,IRF7,IRF9,ISG20,JAK2,KCNJ2,KLC4,MAD2L1,NLRC3,OAS2,OSBPL9,PAK1,PDE4B,PDLIM5,PML,PROM1,RABEP2,SORBS2,STAT1,STAT2,STAT3,STX11,TDRD5,TFEB,TLR3,TNFRSF10A,TNFSF10,TRIM21,TRIM6-TRIM34,WDR7 | 141 (5) |
| isobutylmethylxanthine | NA | chemical toxicant | Activated | 2.01e+00 | 0.0e+00 | ACE,ACSL3,AGT,ANGPTL4,CAV1,CAV2,CCND1,CCNE1,CDKN1A,CIDEC,DHRS3,E2F4,EGR2,HSD17B7,IDH1,IRF7,JUN,KLF4,LGALS12,MERTK,Mt1,NCOA2,NR1H3,PCNA,PDE3B,PDE4D,PLAT,PTGFRN,PTPRN,RBL2,SCARB1,Scd2,SERPINE1,SREBF1,STAT1,STAT2,TH,THBS1,TIMP3,TNC,TRPV1 | 875 (26) |
| FSH | NA | complex | Activated | 2.00e+00 | 0.0e+00 | ADAMTS1,Akr1b7,AQP3,ATP2A2,AXIN2,BAD,CCND1,CD55,CDKN1C,COL18A1,CX3CL1,DHRS3,DUSP1,DUSP14,DUSP9,ESR1,FDX1,FOSL1,GBP1,GDE1,GEM,GNRHR,GPRC5A,GPRC5B,HCRTR1,HDAC5,HK2,ID4,ING1,INHA,INHBB,ISG20,ITGA5,JUN,LOX,MAP2K3,MAP3K5,MBD2,MICOS10-NBL1/NBL1,PAWR,PCNA,PCSK6,PDLIM3,PENK,PLA1A,PLAT,PLIN3,POP5,PRKX,PTP4A1,PTPN1,PTPRN,RGS7,SCARB1,SERPINE1,SRD5A1,STAT1,STK24,TFRC,TGFB2,TGFBR3,THBS1,TK1,Tpm4,TRIB1,UPP1,VCL,VEGFC,VGF | 882 (22) |
| MYO6 | -3.40e-01 | other | Activated | 2.00e+00 | 0.0e+00 | ACTG1,ATXN1,DUSP1,DUSP5,EGR3,GLRX,GRB14,HDAC4,IER3,INHA,MAP2K3,MAST4,STX11,TNC,TRPM4,VGLL3 | 605 (12) |
| phencyclidine | NA | chemical drug | Activated | 2.00e+00 | 7.0e-02 | GAL,GRIN1,IER3,NRG1 | NA |
| EMD | 5.20e-01 | other | Activated | 2.00e+00 | 8.0e-02 | IER3,IRF1,STAT1,TGM1 | NA |
| RNF138 | -2.70e-01 | enzyme | Activated | 2.00e+00 | 1.4e-01 | GADD45B,ICAM1,IER3,SH2D5 | NA |
| MDK | 1.90e-01 | growth factor | Activated | 2.00e+00 | 1.9e-01 | ACE,FOSL1,PLAT,RELT,WNT5A | NA |
| ELF4 | -7.00e-02 | transcription regulator | Activated | 2.00e+00 | 4.4e-01 | CDKN1A,DUSP1,DUSP5,KLF4 | NA |
| SELPLG | -3.30e-01 | other | Activated | 2.00e+00 | 5.0e-01 | CDKN1A,IL1R2,PRKCD,THBD | NA |
| DMD | NA | other | Activated | 2.00e+00 | 1.0e+00 | ACTG1,AMPD1,ARPP21,CDKN1A,DNAJB6,DNAJC5,FBXO32,GMPR,MLF1,MSI2,MYOM2,NOS1,PLPP3,PROX1,PSTPIP2,PTGFRN,RPL3L | NA |
| lomustine | NA | chemical drug | NA | 1.99e+00 | 0.0e+00 | ASNS,Bex2/LOC100912195,CDCP1,CLDN4,Ctla2a,FXYD5,GTPBP4,IER3,LAMC2,MCM3,PLA1A,RBM3,TSPAN8,UPP1 | NA |
| SP4 | -1.90e-01 | transcription regulator | NA | 1.99e+00 | 2.0e-02 | CCL24,CCND1,CDKN1A,GRIN1,HSPA5,IL18,PRKCD,STAT3,TNFSF10 | NA |
| NCOR1 | -1.60e-01 | transcription regulator | NA | 1.99e+00 | 2.0e-02 | BCL3,CCND1,CDKN1A,CXCL10,DUSP1,IRF7,NR1D1,Oas1b,OAS2,Oasl2,OXNAD1,SREBF1,STAT2,UCP3,WARS2 | NA |
| 15-deoxy-delta-12,14 -PGJ 2 | NA | chemical - endogenous mammalian | NA | 1.99e+00 | 0.0e+00 | ADAMTS4,BIRC2,BRIX1,CAV2,CCL5,CCND1,CD200,CDKN1A,CXCL10,CXCL11,DNAJB1,E2F4,ESR1,GADD45A,GAL,ICAM1,IRF1,JUN,KLF4,NFKBIB,NQO1,P4HA1,PARP1,RORA,SCARB1,SERPINE1,SFTPB,SOCS1,SREBF1,STAT1,TFCP2L1,TH,TXNRD1 | 690 (16) |
| linoleic acid | NA | chemical - endogenous mammalian | NA | 1.99e+00 | 2.9e-01 | ANGPTL4,DUSP1,HSPA5,ICAM1,OLR1,PLIN4,REN,UCP2 | NA |
| 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone | NA | chemical reagent | NA | 1.99e+00 | 1.0e-02 | CCND1,CCNE1,CDKN1A,GADD45A | 323 (7) |
| ERVW-1 | NA | other | NA | 1.99e+00 | 8.0e-02 | CCL5,CDKN1A,CREB3L1,HSPA5 | NA |
| CSF1 | -5.10e-01 | cytokine | NA | 1.99e+00 | 0.0e+00 | BAD,BCL2L11,BHLHE40,CCL5,CCND1,CCNE1,CD83,CD86,CDC25A,CDKN1A,CLEC7A,CPM,CXCL10,CXCL11,DUSP1,DUSP5,DUSP9,EGR2,EGR3,F2R,FDFT1,HK2,HMGCS1,HSD17B7,HSPA5,IL18,IRF1,IRF7,ITGA5,ITGAV,ITGAX,JUN,LSS,MERTK,MX1,NFATC1,OAS2,OSCAR,PCNA,SERPINB2,SLC7A5,SOCS1,SOCS2,STAT1,THBS1,TLR2,TLR5,TPT1 | 715 (19) |
| F2 | -4.80e-01 | peptidase | NA | 1.98e+00 | 0.0e+00 | AKR1B1,ANGPT1,ANGPTL4,BCL3,BIRC2,CCND1,CD55,CDKN1A,CORO1C,CX3CL1,CXCL10,DAAM1,DUSP1,EHD4,EIF4A1,F2R,F2RL3,FOSL1,GREM1,HMGA1,HYAL3,ICAM1,IER3,IL15RA,JUN,LIPC,MAP3K5,MYBL2,NCOA7,NR4A3,NUAK2,NUP62,PDGFB,PDIA4,PLAT,PLCB3,PPIF,PROCR,RGS3,SAMD4A,SERPINE1,SKP2,TGFB2,THBD,THBS1,TNFSF10,TRAF1,TXNDC5 | 788 (18) |
| GSK 650394 | NA | chemical reagent | NA | 1.98e+00 | 0.0e+00 | ESR1,HSPA5,ORAI1,SLC9A3 | NA |
| phenethyl isothiocyanate | NA | chemical drug | NA | 1.98e+00 | 1.0e-02 | BCL2L11,CCND1,EEF2K,ESR1,GSTT2/GSTT2B,HMMR,IDH1,KAT2B,MAP2,MAP2K3,PCNA,RBBP6,RLIM,SH2D2A,TTC1,TXNRD1,UBE3D | 641 (18) |
| cyclic GMP | NA | chemical - endogenous mammalian | NA | 1.98e+00 | 1.0e-02 | CDKN1A,MARCKSL1,RAD1,SERPINE1,VCL | 721 (23) |
| DNASE2 | -2.40e-01 | enzyme | NA | 1.98e+00 | 1.0e-02 | CXCL10,DHX58,IRF7,Oasl2,RTP4,TNFSF10,USP18 | NA |
| GALNT2 | -4.40e-01 | enzyme | NA | 1.98e+00 | 3.0e-02 | EPS8L1,PTP4A1,SLC6A4,SRP54 | NA |
| Hmgb1 | -2.20e-01 | transcription regulator | NA | 1.98e+00 | 5.0e-02 | AGER,CCND1,CDKN1A,CHGB | NA |
| naringenin | NA | chemical - endogenous non-mammalian | NA | 1.98e+00 | 6.0e-02 | CCL5,CLDN4,CXCL10,GJA1,HSPA5,SREBF1,TLR2 | NA |
| MAZ | 1.50e-01 | transcription regulator | NA | 1.98e+00 | 8.0e-02 | CAV1,CCL24,CDKN1A,CX3CL1,PDIA4,STAT3,TNFSF10 | NA |
| PDGF-AA | NA | complex | NA | 1.98e+00 | 1.7e-01 | CDKN1A,FGF7,ID4,PCNA | NA |
| ouabain | NA | chemical drug | NA | 1.98e+00 | 1.8e-01 | ATP4A,CDKN1A,HSPA5,PCNA,SLC6A5,TNFRSF10A | NA |
| 7(R)-maresin 1 | NA | chemical - endogenous mammalian | NA | 1.98e+00 | 2.3e-01 | ATP2A2,JUN,STAT1,TGFB2 | NA |
| CD83 | -8.00e-01 | transmembrane receptor | NA | 1.98e+00 | 2.9e-01 | CD86,KLF4,MERTK,NFATC1 | NA |
| intralipid | NA | chemical drug | NA | 1.98e+00 | 3.0e-02 | ANGPTL4,GAL,PENK,UCP3 | NA |
| EP300 | -1.10e-01 | transcription regulator | NA | 1.98e+00 | 0.0e+00 | AGT,AMPD1,ANGPT1,AQP5,AXIN2,BDKRB2,CCND1,CCNE1,CDC25A,CDC42EP3,CDCP1,CDKN1A,CKB,CLASP2,COL2A1,CRISPLD2,CRYAA/LOC102724652,DHRS3,DUSP1,DUSP22,EDARADD,EGR2,EPSTI1,FDX1,FMNL2,GFRA1,GREB1,H6PD,HDAC11,HES6,HK2,HLA-G,ID3,IL12RB1,IL15RA,IL17RE,IRF6,JUN,JUP,LAMC2,LEP,MCM3,MSH2,MSH5,NDRG1,OLR1,PARP1,PBX1,PDE10A,PRKCD,RAD51,RAPGEF3,RAPGEF4,REN,RNF39,RTP4,SCN4B,SDC1,SFTPC,SKP2,SLC7A11,TGFB2,TK1,TLE2,TLE6,TLR2,TMEM38A,TMPRSS4,TNC,TRAF1,UBE2C,ULK2,USP18,WNT5B,XRCC6 | 772 (22) |
| EGF | 2.80e-01 | growth factor | NA | 1.98e+00 | 0.0e+00 | ADAMTS1,ANGPT1,ANGPTL4,ANPEP,AQP3,ARF6,ATM,ATP2A2,AURKA,BIRC2,BRIX1,CAV1,CCND1,CCNE1,CDKN1A,CHGB,CISH,CLCN3,CTRB2,CXCR3,DIO2,DUSP1,DUSP5,EFNB2,EGR2,EGR3,EPAS1,ESR1,FABP7,FOSL1,FSCN2,GADD45A,GAL,GAS1,GJA1,GLG1,GNRHR,GPR50,HMGCS1,ICAM1,IDH1,IER3,IGFALS,IL1R2,ITGA2,JAK2,JUN,LAMB3,MAD1L1,MAD2L1,MAP3K5,MYCN,NCL,NCOA2,NR4A2,NR4A3,NRG1,PCNA,PLAT,PLPP3,PLSCR1,PRKDC,PROM1,PTPN1,PTPRN,REN,RFFL,RRM2,S100G,Scd2,SCNN1B,SDC1,SERPINB2,SERPINE1,SFTPC,SREBF1,STAT1,STAT3,TFCP2L1,TGM1,TGM2,TH,THBS1,TIMP3,TNC,TSPAN8,TYK2,VCAN,VCL,VDR,VEGFC,VIL1,XRCC6 | 841 (20) |
| CARM1 | -1.90e-01 | transcription regulator | NA | 1.98e+00 | 0.0e+00 | CCNE1,CDKN1A,CKB,CXCL10,DLG5,EGR3,FTL,GADD45A,ICAM1,STC2 | 720 (24) |
| N-acetylmuramyl-L-alanyl-D-isoglutamine | NA | chemical - endogenous non-mammalian | NA | 1.98e+00 | 2.3e-01 | AXIN2,BDKRB2,CCL5,CD200,CD86,CXCL11,ICAM1,ITGAV | NA |
| STK40 | 2.20e-01 | kinase | NA | 1.97e+00 | 0.0e+00 | DLL3,FUT10,HDAC5,JUN,LEF1,OSR1,SFTPB,SFTPC,ST8SIA6,TBX6,TLR5,TXNRD3,WNT5A,WNT5B | NA |
| YBX1 | 8.00e-01 | transcription regulator | NA | 1.97e+00 | 3.7e-01 | APOL2,CCL5,CDKN1A,FGF7,ICAM1,INHA,KLF4,LRP2,MUC13,NRG1,PDGFB,RRM2,STC2 | NA |
| THBS1 | 1.02e+00 | other | NA | 1.97e+00 | 4.4e-01 | PARP1,TGFB2,THBS1,TNFRSF10A | NA |
| IRF4 | -6.00e-02 | transcription regulator | NA | 1.97e+00 | 0.0e+00 | ATF4,CXCL10,CXCL11,DOCK8,GBP1,IL12RB1,IL15RA,IL33,INPP4B,IRF1,IRF2BP2,IRF7,IRF9,ISG20,JAK2,LEF1,MAP2K5,PCNA,PLSCR1,PROCR,RAD51,RORA,STAT1,STAT2,TK1,TNFSF10,TRAF1,TRIM21,YBX1 | 683 (18) |
| IL3 | NA | cytokine | NA | 1.97e+00 | 0.0e+00 | BCL2L11,Ccl6,CCND1,CD83,CD86,CDKN1A,CEBPZ,CISH,EGR2,EGR3,F2R,GADD45A,GADD45B,HK2,HNF1A,HSPA2,HSPA5,ICAM1,IL33,ITGAV,ITGAX,JUN,LILRB4,Mt1,NCL,NEDD9,NFATC1,NIFK,PDE1B,PPM1G,PROX1,RBM3,SERPINB2,SLC3A2,SLC7A11,SLC7A5,SOCS1,TK1,TLR2,TNFSF10,TPSAB1/TPSB2,TYK2,Ubb,UCP2,YBX1 | 601 (17) |
| NEUROD1 | -1.00e-02 | transcription regulator | NA | 1.97e+00 | 2.4e-01 | ABCC8,ACTN4,ATP2A2,CDKN1A,NR0B2,SCLY,SCNN1B | NA |
| MECOM | NA | transcription regulator | NA | 1.97e+00 | 0.0e+00 | CDKN1A,ITGA2B,MAP3K14,PBX1,PML,SCUBE3,SERPINE1,SKIL,ZFPM2 | 266 (7) |
| MFSD2A | -5.60e-01 | transporter | NA | 1.97e+00 | 0.0e+00 | FADS1,FDFT1,HK2,IDH1,LSS,Scd2,SREBF1 | NA |
| aristolochic acid I | NA | chemical toxicant | NA | 1.97e+00 | 6.0e-02 | AGER,CDKN1A,HIBCH,LEP,MAP1LC3A | NA |
| NRG1 | 2.96e+00 | growth factor | NA | 1.97e+00 | 1.0e-02 | ANGPT1,ATF1,ATF4,BIN1,CAV1,CCND1,CCNE1,CDKN1A,CXCR3,DUSP1,EGR2,EGR3,ENO3,FOSL1,FSCN1,FSCN2,GLG1,GRIN2C,HK2,HMGA1,HMMR,IER3,ITGAV,JUN,L1CAM,NDRG1,NR4A3,NRG1,SERPINE1,TGFB2,TGM2,THBS1,TK1,VCL,VEGFC,XRCC6 | 731 (21) |
| MAPK1 | -2.80e-01 | kinase | NA | 1.96e+00 | 0.0e+00 | ANGPTL4,ANPEP,ARSB,AURKA,CAV1,CCL5,CCND1,CCNF,CDK19,CDKN1A,CISH,CPPED1,CXCL11,DEPTOR,DUSP1,EGR2,EHD1,ENO3,ESR1,FBXO32,GBP1,GBP5,GFOD1,GMNN,GNRHR,GPR83,GRAMD1B,IFI16,IFI35,IFI44,IFIH1,IL12RB1,IRF7,IRF9,ISG20,ITGA2B,ITGA5,ITGAV,JUN,L3MBTL1,LOX,MSH5,MYBL2,NFATC1,NPTX2,NT5E,OAS2,OSBPL3,PDGFB,PDLIM3,PLA2G4F,PLSCR1,PML,RAD54L,SCNN1A,SERPINE1,SHANK2,SOCS2,SP110,STAT1,STAT2,TLR3,TNFSF10,TRIM21,UBE2C,UBE2I,USP18,VDR,ZNF184 | 695 (21) |
| sterol | NA | chemical - endogenous mammalian | NA | 1.96e+00 | 8.0e-02 | FDFT1,GPAM,IDH1,SCARB1,Scd2 | NA |
| TLR5 | -1.23e+00 | transmembrane receptor | NA | 1.96e+00 | 2.2e-01 | CCL5,CD86,ICAM1,IL33,NR1H4 | NA |
| BECN1 | 1.10e-01 | other | NA | 1.96e+00 | 3.7e-01 | BCL2L11,CCL5,MAP1LC3A,NPHS2 | NA |
| SUMO2 | 9.00e-02 | enzyme | NA | 1.96e+00 | 0.0e+00 | AGT,CAV1,CAV2,CEACAM1,GRB14,HLA-G,HMGA1,Ifgga2l1/RGD1309362,NR0B2,TNC,TNFRSF21 | 618 (14) |
| HIPK2 | -3.10e-01 | kinase | NA | 1.96e+00 | 1.0e+00 | ABCB10,CDKN1A,EPOR,NQO1 | NA |
| ERK1/2 | NA | group | NA | 1.96e+00 | 4.0e-02 | ADAM10,BCL2L11,BIRC2,CAV1,CCL5,CCND1,CD86,CDC25A,CDKN1A,COL2A1,CXCL10,DUSP1,EFNB2,ESR1,FOSL1,FZD1,GJA1,HK2,HMGA1,HSPA5,ICAM1,ID3,IL19,ITGA2,JUN,KCNH2,MYCN,NR4A3,PCNA,RAD51,SERPINE1,SKIL,TH,TRIM63,UNC119,VCAN | NA |
| zerumbone | NA | chemical - endogenous non-mammalian | NA | 1.96e+00 | 1.0e-02 | ATF4,BIRC2,CCND1,ICAM1,TNFRSF10A,TRAF1 | NA |
| INSIG2 | -3.40e-01 | other | NA | 1.95e+00 | 6.0e-02 | ATF4,FDFT1,GPAM,SREBF1 | NA |
| miR-9-5p (and other miRNAs w/seed CUUUGGU) | NA | mature microRNA | NA | 1.95e+00 | 1.0e+00 | FGF16,HIBCH,JAK2,SYTL4 | NA |
| ROCK2 | -5.40e-01 | kinase | NA | 1.95e+00 | 1.0e+00 | DSP,HK2,ICAM1,SERPINE1,STAT3 | NA |
| cholesterol | NA | chemical - endogenous mammalian | NA | 1.95e+00 | 0.0e+00 | ADAM11,AGT,ATF4,CAV1,CAV2,CXCL10,CYB5B,FADS1,FDFT1,GRIN1,HES6,HHIP,HMGCS1,HNRNPD,HSPA5,ICAM1,IL10RB,ITGAX,KCNA5,MAP2,Meis1,NR0B2,NR1H3,NR4A2,NR4A3,SAA2-SAA4,SCARB1,SLC28A3,SLC7A5,SREBF1,THBS1,TIMP3,UCP3,ZFPM2 | 582 (18) |
| GDF11 | 3.60e-01 | growth factor | NA | 1.95e+00 | 1.0e-02 | ATP2A2,BAMBI,BMP7,COL2A1,COMP,ICAM1,ITGA2,ITGA5,ITGAV,LAMB3,NFATC1,PDGFB,THBS1 | 263 (7) |
| SOX30 | NA | transcription regulator | NA | 1.95e+00 | 1.0e+00 | CDKN1A,ODF3,REC8,SLFNL1 | NA |
| 1-methyl-4-phenylpyridinium | NA | chemical toxicant | NA | 1.95e+00 | 2.1e-01 | ATF4,BCL2L11,CCND1,TFRC | NA |
| hydrogen peroxide | NA | chemical - endogenous mammalian | NA | 1.95e+00 | 0.0e+00 | ACAT2,ACE,AGT,ANKRA2,ATG7,AURKA,BAD,BANP,BCL2L11,CAV1,CCL5,CCND1,CCNF,CD55,CD86,CDKN1A,CNR1,CXCR3,DNAJB1,DUSP1,E2F4,ELN,EPAS1,EZH2,FBXO32,FDFT1,FOSL1,GADD45A,GADD45B,GLRX,HNRNPA1,HSPA5,ICAM1,ID3,IDE,IL10RB,ITGA2,JUN,KLF4,LEF1,MAP1LC3A,NFIL3,NOS1,NQO1,PAH,PARP1,PDGFB,PDIA4,PKIA,PSTPIP2,RIOK3,SCNN1A,SERPINE1,SERPINH1,SFTPB,SLC30A1,SLC39A7,SLC7A11,STAT3,TFRC,TGFBR3,TGM2,TTPA,TUBB2A,UCP2,VDR,WNT5A,XRCC6 | 703 (20) |
| mir-26 | -3.00e-02 | microRNA | NA | 1.95e+00 | 2.3e-01 | CCNE1,CHORDC1,EZH2,FGF9 | NA |
| ELK1 | -2.80e-01 | transcription regulator | NA | 1.94e+00 | 1.2e-01 | CDKN1A,EGR2,EGR3,FOSL1,ITGAV,JUN,MTHFD2,SKP2,SLC7A11,THBS1 | NA |
| SOCS1 | 6.50e-01 | other | NA | 1.94e+00 | 0.0e+00 | CCND1,CCNE1,CD200R1,CD86,CDKN1A,CISH,CXCL10,CXCR3,DUSP1,GBP5,H2-T24,ICAM1,IFI16,IFI44,Ifi47,IFIH1,IL12RB1,IRF1,IRF7,ISG20,JAK2,JUN,MAP3K5,MX1,Oas1b,OAS2,Oasl2,SOCS1,STAT1,STAT3,TGM2,TLR3,USP18 | 580 (15) |
| tributyrin | NA | chemical drug | NA | 1.94e+00 | 0.0e+00 | CD55,CDKN1A,DUSP1,DUSP14,GBP1,HDAC4,HNRNPD,HSPA5,ID3,NDRG1,OLR1,PDLIM5,SAMD4A,SERPINB2,SLC30A1,UGCG | 415 (8) |
| RASSF1 | 8.90e-01 | other | NA | 1.93e+00 | 1.0e-02 | BHLHE40,CAV1,CAV2,CCND1,CDKN1A,EFNB2,ESR1,KLF4,LDB2,MAP3K5,MRAS,PAK1,PROM1,RNF182,TGM2,TUBB2A | 685 (19) |
| ESR2 | 1.00e-01 | ligand-dependent nuclear receptor | NA | 1.92e+00 | 0.0e+00 | ABCC4,ABLIM1,ACKR3,ACSL3,ADAMTS1,ADORA1,AGT,ANPEP,APPBP2,AQP3,ATAD2,AURKA,BAMBI,BCAT1,BIN1,C8orf44-SGK3/SGK3,CABP7,CAV1,CCND1,CCNE1,CDC25A,CDKN1A,CDKN1C,CHRM1,CLDN4,CLIC5,COMP,CPM,DDB2,EGR3,EIF4E,ELOVL5,EPHA5,ESR1,ETV1,EZH2,FADS1,FAM110C,FSCN1,GADD45B,GALNT7,GJA1,GLRX,GNL3,GREB1,GREM1,GYG1,HMGA1,HMGCS1,HMMR,HSD17B7,HSPA2,IFI35,IFI44,IFIH1,IL20,INPP4B,IRF7,ITGA2,ITGAV,KLF4,LAMB3,LOX,LTBP1,MAD2L1,MAP2K3,MCM4,ME2,MICOS10-NBL1/NBL1,MTHFD2,MYPN,NDRG1,NEDD9,NFYA,NPM2,NR4A3,NRG1,PARP14,PCNA,PDGFB,PDLIM3,PDLIM5,PIBF1,PLAT,PLK1,PMEPA1,POLD1,PPM1G,PROM1,PTGFR,RAI2,RRP12,SCARB1,SERPINE1,SKP2,SLC5A7,SMC2,SOCS2,SORD,SOX11,SPDEF,ST8SIA6,STK24,SYTL4,TDRD5,TGFB2,TGM2,THBS1,TIGD3,TK1,TRIB1,TSC22D1,UBE2J1,USP8,ZMIZ1 | 820 (17) |
| AIRE | NA | transcription regulator | NA | 1.92e+00 | 0.0e+00 | Bmp8b,CCL5,CCRL2,CDC42EP2,CXCL10,CXCL11,ICAM1,IFI44,IRF1,IRF7,MARCKSL1,PARP14,PDE4B,PLPP3,SLC7A11,TLR2,TLR3,TNFSF10,TRAF1,UPP1,VWCE | 296 (7) |
| ANGPT2 | 0.00e+00 | growth factor | NA | 1.92e+00 | 0.0e+00 | AGT,AXIN2,BCL2L11,CCL5,CD86,CDKN1A,COL18A1,CRYAA/LOC102724652,EIF1,EXT2,FGF7,HDAC4,HDAC5,HMGCS1,HSPA1A/HSPA1B,HSPA2,HSPA5,ICAM1,IL18,ITGAX,LEP,MAP4K5,NCOA2,OLR1,POLA1,POLD1,SCNN1A,SCNN1G,SERPINE1,THBS1,TLR3 | 765 (19) |
| VE-821 | NA | chemical reagent | NA | 1.92e+00 | 1.0e-02 | CCL5,CDC25A,GPR50,IL20,ISG20,KLF4,TRAF1 | NA |
| RPSA | 2.50e-01 | translation regulator | NA | 1.92e+00 | 1.0e-02 | CCL5,DUSP1,GBP4,Ifi47,STAT1,TOLLIP,TRAF1 | NA |
| PPRC1 | 8.30e-01 | transcription regulator | NA | 1.92e+00 | 9.0e-02 | ATF4,CHRNA9,DUSP5,HK2,LAMB3,OLAH,OSCAR | NA |
| phenacetin | NA | chemical drug | NA | 1.91e+00 | 6.0e-02 | CLDN4,GTPBP4,IER3,LAMC2,PLA1A,TSPAN8,UPP1 | NA |
| prednisolone | NA | chemical drug | NA | 1.91e+00 | 0.0e+00 | ALS2,ATG10,ATG4C,ATG7,BAD,BIRC2,CD86,CXCL10,DLL1,DUSP1,ESR1,EVA1A,FANCC,FBXO32,HDAC1,IFT172,IL19,Irgm1,ISG20,KANSL1L,LDLRAD4,MAP1LC3A,MYCN,NFIL3,PIK3R4,PLAT,PPCDC,SOCS1,SPON2,STAT1,TGM2,TMEM43,TNFSF10,TRIM63,TXNRD3,UCP3,ULK2 | 663 (20) |
| cobalt chloride | NA | chemical reagent | NA | 1.91e+00 | 1.0e-02 | ABCB10,ADAMTS1,ANPEP,BHLHE40,CA9,CDKN1A,COL18A1,DUSP1,EPAS1,HK2,LEP,NCOA2,NDRG1,PROM1,TFRC,TH | 649 (17) |
| deferoxamine | NA | chemical drug | NA | 1.90e+00 | 0.0e+00 | ANGPT4,ANGPTL4,BHLHE40,CA9,CCND1,CCNE1,CDKN1A,DUSP1,DUSP5,ELN,EPAS1,GADD45A,GADD45B,GEM,HK2,HSPA1A/HSPA1B,ICAM1,IFI16,ISG20,JUN,LEP,MYCN,NDRG1,NFIL3,NR4A2,PLAT,PROM1,SERPINE1,SHMT1,SREBF1,TEC,TFRC,TGFB2,TNFSF10,TSC22D1,UBE2D1,VDR | 716 (22) |
| CD276 | -4.60e-01 | other | NA | 1.90e+00 | 0.0e+00 | CD86,CXCL10,CXCL11,IRF1,IRF7,MX1,OAS2,SOCS1,SOCS2,STAT1 | 645 (16) |
| GPR15LG | NA | cytokine | NA | 1.90e+00 | 0.0e+00 | HSD3B7,IL20,JUN,MAFF,MAP2K5,RAB7B,SEMA3E,SREBF1,TGM1,TXNRD3 | NA |
| 1-(ethylthio)-4-(2-phenylethyl)-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1’-cyclohexan]-5(7H)-one | NA | chemical reagent | NA | 1.90e+00 | 2.0e-02 | BMP7,COL2A1,ESR1,F2R,GMNN,LLGL2,NSUN6,SPDEF,STAT3,TEAD3 | NA |
| KCNIP3 | 3.20e-01 | transcription regulator | NA | 1.90e+00 | 9.0e-02 | AGER,CCL5,CCND1,CX3CL1,GHRL,ITGA2,METRNL,NLRX1,NR1H3,TGM2 | NA |
| RETNLB | NA | other | NA | 1.90e+00 | 1.5e-01 | CCL5,CD86,ELN,FZD1,PLA1A,SOCS2,TINAGL1,TLR2,UBE2C,WNT5A | NA |
| PARPBP | -4.30e-01 | other | NA | 1.89e+00 | 0.0e+00 | AMD1,ELN,INMT,REN,SPON2,TIAM1,TNC | NA |
| abemaciclib | NA | chemical drug | NA | 1.89e+00 | 3.0e-02 | AGT,CEACAM1,ESR1,PLAT,TGFB2,VGF,VWCE | NA |
| laquinimod | NA | chemical drug | NA | 1.88e+00 | 6.0e-02 | ADAMTS15,AMZ1,CX3CL1,Cxcl3,DUSP14,EVA1A,GPR15,IL1R2,INHBB,RIPK4,SERPINB2,SLC7A11,SLC9A3,SPINT1,STBD1 | NA |
| rosiglitazone | NA | chemical drug | NA | 1.88e+00 | 0.0e+00 | ADAMTS1,ADRB3,AGT,ANGPTL4,AQP3,ASCL2,CAV1,CAV2,CCL5,CCND1,CCRL2,CD86,CDKN1A,CIDEC,CLEC7A,CXCL10,CXCL11,DGAT1,DHRS3,DIO2,FDX1,FGF13,FOSL1,GBP1,GIPR,GPAM,GYG1,H6PD,HAS1,HCAR1,HSPA5,ICAM1,IDH1,IL18,IRF1,IRF7,KLF4,LAMB3,Ldha/RGD1562690,LEP,LOX,Muc1,NR1D1,NR1H3,OAS2,OLR1,PCNA,PENK,PEX11A,PLPP3,PNPLA2,PPP2R1B,PRDM16,PTPN1,PTPRO,REN,RORA,SCARB1,SERPINE1,SKP2,SLC27A6,SLC9A3,SOCS1,SPON2,SREBF1,STAT1,STAT2,THBS1,TNC,TRIM63,TSC22D1,UCP2,UCP3 | 666 (21) |
| cyclophosphamide | NA | chemical drug | NA | 1.87e+00 | 1.0e-02 | CCL5,Ctla2a,FLT3,GTPBP4,ICAM1,IER3,IL18,IL1R2,LAMC2,PLA1A,RBM3,SATB1,THBS1,TSPAN8,UGCG,UPP1 | NA |
| STAT3 | 1.01e+00 | transcription regulator | NA | 1.87e+00 | 0.0e+00 | AGT,ANGPTL4,AQP5,ASCL2,ASIC1,ATP10A,BCL2L11,BCL3,CA9,CCL5,CCND1,CCNE1,CCRL2,CD83,CD86,CDC25A,CDKN1A,CEACAM1,CEP70,CLIC5,CLN6,CTF1,CX3CL1,CXCL10,Cxcl3,CXCR3,DLL1,DUSP1,DUSP5,ECT2,EGR2,EGR3,EME1,EPAS1,ESR1,FLRT3,FLT3,FSCN1,FZD1,GADD45A,GBP5,GJA1,GRB10,HEG1,HK2,HNRNPD,ICAM1,IFI16,IFI35,IFI44,IFIH1,Igtp,IL12RB1,IL33,IRF1,IRF7,IRF9,Irgm1,ISG20,ITGA5,ITGAV,JAK2,KAT2B,KLF4,Klrk1,LAMB3,LEP,LILRB4,LOX,LRP2,MAP2,MAP2K5,MRAS,Mt1,Muc1,MX1,NDRG1,NFATC1,NFIL3,NR4A2,NT5E,NUMBL,OAS2,OSCAR,PDGFB,PDIA4,PLSCR1,PML,PROCR,PROM1,REN,RET,RNLS,RORA,RRM2,SERPINB2,Serpinb6b,SERPINE1,SFTPB,SKP2,SLC16A1,SLC2A5,SLC39A10,SLC6A4,SLC9A3,SLFN13,SLFN5,SOCS1,SOCS2,SOX11,SP110,SREBF1,STAT1,STAT2,STAT3,STC2,TGM2,THBD,THBS1,TLR3,TMC8,TNFSF10,USP18,USP7,VCAN,VEGFC,WNT5A | 722 (19) |
| cytarabine | NA | chemical drug | NA | 1.87e+00 | 6.0e-02 | BCL2L11,CCL5,CD55,CD86,CDC25A,CDKN1A,GADD45A,ICAM1,TGFB2,TLR2 | NA |
| HTT | -1.20e-01 | transcription regulator | NA | 1.87e+00 | 0.0e+00 | ABCC10,ACAT2,ADAMTS4,AGT,AMD1,ARPP21,ATP2A2,ATP2B2,ATP2C1,ATPAF2,B4GAT1,BAIAP2,BCL2L11,BCL3,BHLHE40,BIRC2,BTG3,CCL5,CCND1,CDKN1A,CIT,CNR1,COL18A1,CX3CL1,DIO2,DLL1,DNAJB1,DUSP5,EGR2,ENO3,ETV1,FABP7,FDFT1,FOSL1,GRIN1,GRIN2C,HAPLN3,HIVEP2,HMGA1,HMGCS1,HSPA5,IFI16,JUN,JUP,KCNJ1,KCNJ2,KLF4,LOX,MANEAL,MAP2,Mt1,NCS1,NDUFA5,NFIL3,NOS1,NR4A2,PABPC4,PCNA,PDE10A,PDE1B,PDE4B,PDK2,PENK,PIGF,POR,PPRC1,PRKACB,PRKCB,PRKCD,PROM1,PTBP1,RASD2,RGS9,RPH3A,RRS1,SATB1,Scd2,SCN4B,SERPINH1,SMC2,SOCS2,TBX6,TFRC,TGM2,TH,TIAM1,TIMP3,VAPA,VGF,YBX1 | 808 (26) |
| PTPRR | 4.30e-01 | phosphatase | NA | 1.86e+00 | 0.0e+00 | BTBD2,CALCOCO1,DHRS3,FOSL1,FYCO1,HDAC5,ITGA5,JUN,KLC4,MAD1L1,MYO5B,NINL,PACSIN3,PELI3,PEX14,PLCB3,PROCR,TELO2,TMEM178A,TNIP1 | NA |
| NFkB (complex) | NA | complex | NA | 1.86e+00 | 2.0e-02 | ACKR3,AGER,AGT,AQP5,ATP2A2,BAD,BAMBI,BCL3,BIRC2,BLVRA,CCL5,CCND1,CD83,CD86,CDKN1A,CFTR,CGREF1,COL18A1,COL2A1,CX3CL1,CXCL10,CXCL11,DUSP5,EPAS1,GADD45A,GADD45B,GCH1,GRIN1,ICAM1,IER3,IL15RA,IL18,IL19,IRF1,IRF7,ITGAV,JUN,Ldha/RGD1562690,MSH2,NCOA7,NOS1,NR1D1,NUAK2,NUMBL,NUP62,OLR1,PIM3,PKP1,PLK1,PPIF,PRKCD,SCLY,SENP2,SERPINB2,SERPINE1,SH2D5,SLC2A5,SLC7A5,SOCS1,TERF2IP,TFRC,TGM2,TLR2,TNFSF10,TNIP1,TOLLIP,TRAF1,VEGFC,WNT5A,XRCC6 | NA |
| JAG1 | 2.80e-01 | growth factor | NA | 1.86e+00 | 0.0e+00 | CCND1,CD86,CDKN1A,CLDN4,DUSP1,DUSP5,ESR1,F11R,GADD45A,ITGAV,LAMC2,PCNA,RNF128,TGFB2,TIMP3,TNC | 745 (21) |
| ZC3H12A | 2.40e-01 | enzyme | NA | 1.86e+00 | 7.0e-02 | ABCC4,AFMID,ARAP2,B4GALNT1,BCL3,CDK5RAP1,CEACAM1,CSRP2,DUSP1,DUSP5,ELOVL5,GBP4,GBP5,ICAM1,IL1R2,IL33,PDIA4,RHOF,SEMA4B,TNIP1,TRIB1,ZMIZ1 | NA |
| EGFR | -4.30e-01 | kinase | NA | 1.85e+00 | 0.0e+00 | AMD1,ASCL2,AXIN2,B4GAT1,BCL2L11,BZW2,CAV1,CCL5,CCND1,CDCP1,CDKN1A,CPM,CXCL10,DUSP1,EFNB2,EGR3,EHD1,EIF4A1,EIF4E,EIF5A,EIF6,ERCC6L,ESR1,EXT2,F11R,F2R,FABP7,FGF7,FOSL1,GADD45A,GBP1,GJA1,GNPDA1,HK2,HMGA1,HNRNPA1,HNRNPD,HSPA5,ICAM1,IER3,IL33,IQUB,IRF1,ITGA2,JUN,LAMB3,LAMC2,LEF1,MTHFD1,MYBL2,NCL,NT5E,OSMR,PARP2,PBX1,PCNA,PDLIM5,PLAT,PLK1,PROM1,RAI14,SCARB1,SDC1,SERPINE1,SKP2,SLC7A11,SLC7A5,STAT3,SYTL4,TCERG1,Tchh,TFRC,TGM2,THBS1,TIMM9,TNC,TSPAN1,TUBB2A,TUBB4B,VCAN,VCL,VDR | 813 (19) |
| IL5 | NA | cytokine | NA | 1.85e+00 | 0.0e+00 | ASNS,ATF4,ATXN1,BCL3,BIRC2,CCNE1,CCRL2,CD55,CDKN1A,CEACAM1,CISH,CSF2RB,CXCR3,DUSP5,EGR2,EGR3,EPOR,GADD45A,GBP4,GPAM,GSTT2/GSTT2B,HMMR,HSPA5,HSPH1,ICAM1,IER3,IL1R2,IRF7,ITGAV,METRNL,NDRG1,NFIL3,P4HA1,PDE4B,PPIF,RBM3,SAP30,Scd2,SEMA4A,SLAIN1,SLC7A5,SLFNL1,SNTB1,SOCS1,SOCS2,TRA2A,UPP1 | 759 (17) |
| TGFB1I1 | -7.00e-02 | transcription regulator | NA | 1.85e+00 | 1.4e-01 | CDKN1A,KLF4,LTBP1,SERPINE1 | NA |
| AMPK | NA | complex | NA | 1.85e+00 | 9.0e-02 | ACE,BCL2L11,CDKN1A,CXCL10,FBXO32,FSCN1,GJA1,NR0B2,ORAI1,SERPINE1,SREBF1,STAT1,UCP2,UCP3,YBX1 | NA |
| RC3H1 | NA | enzyme | NA | 1.85e+00 | 0.0e+00 | CCL24,CCL5,FOSL1,IFI16,IFI44,IFI44L,IRF1,IRF9,MX1,OAS2,PARP9,PLSCR1,SDC1,STAT1,STAT2,TRIM21,WNT5A | 708 (15) |
| trichostatin A | NA | chemical drug | NA | 1.84e+00 | 0.0e+00 | ABCB10,ABCC4,ADAMTS1,AGT,AKR1B1,ALS2,ANGPT1,APPBP2,ATAD2,ATF1,BAD,BAIAP2,BCAT1,BCL2L11,BLVRA,C8orf44-SGK3/SGK3,CA9,CCND1,CD86,CDKN1A,CDKN1C,CGREF1,CISH,COL11A2,COL2A1,CSE1L,CXCL10,DHRS3,DUSP1,EFNB2,EHD1,EIF4E,ESR1,F2R,FGF7,FLRT3,FTL,GADD45A,GLRX,GREB1,GRIN1,HDAC1,HDAC11,HMGCS1,HNRNPD,HSPA5,ICAM1,ID3,IDH1,ING1,IRF1,ITGAX,JUP,KLF4,L1CAM,LAT,LEF1,LIPH,LOX,LTBP1,MAD1L1,MAP2,MBNL1,MCM3,MICALL2,mir-154,MLH1,MSI1,MYCN,MYOF,NARF,NDRG1,NFATC1,NIFK,NQO1,NR0B2,NR1H3,NR4A2,OXTR,PAH,PAK1,PBX1,PCNA,PDLIM5,PENK,PHF19,PIGF,PINX1,PLK1,PNPLA2,PPRC1,PRKCD,PTBP2,RAD23B,RASSF1,RASSF3,RET,RIOX2,RLIM,SATB1,Scd2,SCNN1A,SCNN1B,SCNN1G,SDC1,SERPINE1,SIRT4,SLC12A5,SLC38A1,SLC5A1,SLC6A4,SLC7A11,SLC9A3,SOCS1,SOX12,SREBF1,STAT3,STC2,STEAP2,TGM1,TGM2,THBS1,TIAM1,TIMP3,TK1,TLR2,TMEM164,TMPO,TNC,TNFRSF10A,TNFSF10,TRADD,TXNRD1,UNC5C,USP7,VCAN,VCL,VEGFC,WNT5A,XPO1 | 736 (15) |
| TGFBR1 | 1.10e-01 | kinase | NA | 1.84e+00 | 0.0e+00 | Acan,BHLHE40,CCND1,CD86,CDKN1A,CXCL10,EGR2,FGF9,GAS1,GJA4,ID4,KLF4,LTBP1,OSR1,PDGFB,PIGF,PRKCB,RGS3,SCX,SERPINE1,SFTPB,STAT1,TPSAB1/TPSB2,VEGFC | 695 (21) |
| phosphate | NA | chemical - endogenous mammalian | NA | 1.83e+00 | 2.0e-01 | ATM,BLVRA,CIT,DIO2,F2R,FOSL1,GALNT3,HK2,HSPA5,MAP2K3,PCNA,STC2 | NA |
| CD28 | 2.70e-01 | transmembrane receptor | NA | 1.82e+00 | 0.0e+00 | ANAPC1,ATM,BHLHE40,BIN1,CCND1,CCNE1,CD86,CISH,CNIH4,CXCR3,DUSP14,DUSP22,E2F4,EGR2,EIF4E,GBP1,GNL2,GTF2IRD1,GTPBP4,HK2,HNRNPA1,HSPA1A/HSPA1B,IL10RB,IL12RB1,IL15RA,IRF1,JUN,KDELR2,LCP1,LTBP1,NCL,NFATC1,NOS1,OAZ1,OPRD1,ORAI1,PDE4A,PDE4B,PDE4D,RAD23B,RNF128,RORA,SH2D2A,SLC7A5,SOCS1,SOCS2,STAT3,STEAP2,TFRC,THBS1,TNFSF10,TNFSF18,TSC22D1,XRCC6,ZFYVE9 | 496 (15) |
| PAX6 | NA | transcription regulator | NA | 1.82e+00 | 3.0e-02 | CCND1,CEACAM1,CRISPLD2,CRYAA/LOC102724652,EEF2K,EFNB2,ETV6,FABP7,GIPR,GLP1R,Irx3,L1CAM,MCM3,NECAB2,NUMBL,PALM,RFFL,SMC2,SOCS1,SPAG1,TBC1D9,THNSL1,TMEM252,TNC,UROS,VSX2 | NA |
| AICAR | NA | chemical - endogenous mammalian | NA | 1.82e+00 | 2.3e-01 | ATF4,CCND1,CCNE1,CDKN1A,HDAC4,HK2,HSPA5,NQO1,PNPLA2,SCARB1,SERPINE1,SREBF1,UCP3 | NA |
| carbonyl cyanide m-chlorophenyl hydrazone | NA | chemical toxicant | NA | 1.81e+00 | 0.0e+00 | AGT,ATF4,CHRNA9,DUSP5,HK2,IL18,LAMB3,NLRP3,OLAH,OSCAR,PPRC1,SERPINE1 | 406 (10) |
| butyric acid | NA | chemical - endogenous mammalian | NA | 1.81e+00 | 0.0e+00 | CCND1,CCNE1,CD83,CD86,CDC25A,CDKN1A,CDKN1C,CLCN3,DDR1,DUSP1,E2F4,ELK3,EPOR,ESR1,FRMD6,GADD45A,GMPS,GPRC5A,GRIN1,ICAM1,IFI16,INPP5J,IRF1,ITGA5,KLF4,LEP,MAD1L1,MYCN,NCL,NF2,NFATC1,OAS2,PCNA,PDK2,PLAT,PLSCR1,PRKCB,PRKCD,PTPN1,PTPRN,S100G,SERPINB2,SERPINE1,SKP2,SLC26A5,SMPD1,SREBF1,STAT2,STAT3,TGM1,TGM2,TIMP3,TLR2,TRPV1,UCP2,USP7,WNT5A | 698 (20) |
| bleomycin | NA | biologic drug | NA | 1.81e+00 | 0.0e+00 | ACKR3,ANGPT1,BHLHE40,BLM,CCL5,CD300LF,CD86,CDH17,CDKN1A,CSF2RB,CXCL10,DUSP5,ELN,F2R,FOSL1,FZD1,GADD45A,ICAM1,IL18,IRF7,KLF4,LOX,LTBP1,MAFF,MAPKAPK2,PCNA,PLA1A,PLAT,PRPF19,RTP4,SERPINE1,SIKE1,SLFN5,SOCS2,STAT3,TBC1D9,TGFB2,TGIF2,THBS1,TIMP3,TINAGL1,TLR2,TNFRSF10A,UBE2C,WNT5A | 797 (18) |
| ERK | NA | group | NA | 1.81e+00 | 0.0e+00 | ADAM10,AGER,AGT,BCL2L11,BTG3,CAV1,CCND1,CCNE1,CDKN1A,CLDN4,CXCL10,DIO2,DUSP1,E2F4,EGR2,EPAS1,ESR1,EZH2,FOSL1,HAS1,HMGA1,ICAM1,IER3,ITGA2B,ITGAV,JUN,MAFF,NDRG1,PDGFC,RAB7B,RRS1,SERPINB2,SERPINE1,SFTPB,SFTPC,STAT1,TGM2,THBS1,UGCG,VCAN | 823 (24) |
| TGFB3 | -2.60e-01 | growth factor | NA | 1.81e+00 | 1.0e-02 | BHLHE40,CCNE1,CDKN1A,COL2A1,ELN,GJA1,ITGAV,JUN,LEF1,MICAL2,MYO10,PLK1,SERPINE1,SKIL,TGFBR3,THBS1,TIMP3,TNC | NA |
| indican | NA | chemical - endogenous mammalian | NA | 1.80e+00 | 7.0e-02 | AGT,CA9,CDKN1A,ICAM1,REN,THBS1 | NA |
| 4-tert-octylphenol | NA | chemical toxicant | NA | 1.80e+00 | 3.7e-01 | CD55,ESR1,Ldha/RGD1562690,S100G | NA |
| CD3 | NA | complex | NA | 1.80e+00 | 0.0e+00 | ACTN4,ANAPC1,AQP3,ATF4,ATM,BAMBI,BCL2L11,CCL5,CCND1,CCNE1,CD83,CD86,CDC25A,CEACAM1,CISH,CNIH4,CUL4A,CXCL10,CXCR3,DPYSL5,DUSP14,DUSP22,E2F4,EGR2,EGR3,EIF4E,ELK3,FTL,FUT7,GBP1,GNL2,GPRC5A,GTF2IRD1,GTPBP4,HNRNPA1,HSPA1A/HSPA1B,HSPA5,ICAM1,ID3,ID4,IFI35,IL10RB,IL12RB1,IL15RA,IRF1,IRF9,JAK2,JUN,KCNA5,KDELR2,LCP1,LEF1,LTBP1,MTHFD2,NCL,NFATC1,NFX1,NOS1,OAZ1,OPRD1,ORAI1,PABPC4,PCNA,PDE4A,PDE4B,PDE4D,PDIA4,PTP4A1,RAD23B,RBM3,RNF128,RORA,SH2D2A,SLC23A2,SLC26A5,SOCS1,SOCS2,SPOP,STAT1,STEAP2,TFDP2,TFRC,TGM2,THBS1,TLR2,TMPO,TNFSF10,TNFSF18,TOM1L1,TRA2A,TRAF1,TXNRD1,XRCC6,ZFYVE9 | 754 (19) |
| gentamicin C | NA | chemical drug | NA | 1.80e+00 | 0.0e+00 | ADAMTS1,ASNS,Bex2/LOC100912195,CLDN4,Ctla2a,FXYD5,GTPBP4,IER3,LAMC2,MCM3,PLA1A,RBM3,UPP1 | NA |
| IL24 | 5.90e-01 | cytokine | NA | 1.79e+00 | 2.5e-01 | BCL2L11,CCND1,GADD45A,HSPA5,XRCC4,XRCC6 | NA |
| CCR2 | NA | G-protein coupled receptor | NA | 1.79e+00 | 1.7e-01 | CCL24,CCL5,Ccl6,CD86,CX3CL1,CXCL10,IL18,P4HA1,TGFB2,TGM2,THBS1,TNC,VCAN | NA |
| diethylnitrosamine | NA | chemical toxicant | NA | 1.79e+00 | 3.0e-02 | BCL2L11,BIRC2,CCND1,CDC25A,CDKN1A,CSTB,CXCL10,JUN,LAMC2,LY6D,Mt1,NQO1,NR1H3,OGG1,PAH,PCNA,PLSCR1,PRKACB,PROM1,SERPINB2,STAT3 | NA |
| TREM2 | NA | transmembrane receptor | NA | 1.78e+00 | 4.0e-01 | ACTR3B,BAMBI,CD86,FZD9,ITGAX,LOX,TMEM163 | NA |
| pioglitazone | NA | chemical drug | NA | 1.78e+00 | 0.0e+00 | ABCB10,ADRB3,AGER,ANGPTL4,ATF4,ATP2A2,CAV1,CCL5,CCND1,CD86,CDKN1A,CXCL10,EPAS1,FOSL1,HAS1,HSPA5,ICAM1,KLF4,LEP,LIPC,NR4A3,PCNA,PDE3B,RORA,SCARB1,SCNN1G,SERPINE1,SLC9A3,SREBF1,UCP2,UCP3 | 810 (25) |
| diclofenac | NA | chemical drug | NA | 1.77e+00 | 0.0e+00 | ABCC4,ASNS,ATF4,BCAT1,CCND1,CDKN1A,CLDN4,DNAJB1,DNAJB6,EIF4A1,JUN,KLF4,MID1IP1,MTHFD2,OSMR,SERPINE1,SLC16A1,STC2,VEGFC | 718 (25) |
| PD184352 | NA | chemical drug | NA | 1.77e+00 | 2.0e-02 | BCL2L11,CCND1,CYP27B1,ESR1,HSPA5,NR4A3 | NA |
| NOTCH3 | 2.00e-02 | transcription regulator | NA | 1.77e+00 | 1.2e-01 | CDKN1A,CDKN1C,COL18A1,EPAS1,FABP7,ITGA11,ITGAX,MSI1,PBX1,PROM1 | NA |
| TRIM37 | -6.70e-01 | enzyme | NA | 1.76e+00 | 0.0e+00 | CDK5RAP2,CKB,DDR1,GREB1,PARP9,PAWR,PCNA,PEX5,PLCB3,RET | NA |
| ceruletide | NA | biologic drug | NA | 1.76e+00 | 0.0e+00 | ACTG1,ATF4,CCNE1,CEACAM1,CLDN4,DNAJA1,Fus,Gm12854/S100a11,HMGA1,HSPA5,HSPH1,IL33,IRF1,LASP1,MAP1LC3A,MICOS10-NBL1/NBL1,NFATC1,PLIN3,VPS16 | 644 (21) |
| Salmonella enterica serotype abortus equi lipopolysaccharide | NA | chemical toxicant | NA | 1.75e+00 | 0.0e+00 | ABL2,ACKR3,ASNS,CCL5,CCRL2,EGR3,ELOVL7,EZH2,FJX1,FOSL1,GADD45A,GADD45B,GBP1,GEM,GPRC5A,HAS1,IL15RA,IL18,IRF1,KCNJ2,MAD1L1,MAFF,MBNL1,NLRP3,NOCT,NR4A2,PIM3,PLA1A,SERPINB2,THBS1,TMPO,TRAF1,WNT5A,YRDC | 674 (14) |
| ethylene glycol tetraacetic acid | NA | chemical reagent | NA | 1.74e+00 | 0.0e+00 | ATP2A2,BRAF,CD83,CD86,COL2A1,GNRHR,GRIN1,HSPA5,KCNJ2 | 719 (22) |
| PIK3CG | -2.50e-01 | kinase | NA | 1.72e+00 | 5.0e-02 | BCL2L11,CXCL10,EPHB6,GBP4,GBP5,ICAM1,Igtp,IRF1,NFATC1,OAS2,OSCAR,STAT1,TK1,TLR2,TNFSF10 | NA |
| SHH | 4.50e-01 | peptidase | NA | 1.72e+00 | 1.0e-02 | ADAMTS1,AMD1,ANGPT1,AQP5,BCAR1,BMP7,CAV1,CCND1,CCNE1,CDC25A,DAAM1,HHIP,HK2,HMGA1,LASP1,MCM3,MYCN,PCNA,PLAT,RAD51,SERPINE1,SREBF1,TGFB2,TH,THBD,WDR7,WNT5A | 683 (19) |
| KAT2A | -1.60e-01 | enzyme | NA | 1.72e+00 | 0.0e+00 | ACTN4,ADAMTS1,APBB1,CCND1,CCNE1,CDC25A,CSRP2,EPHA5,EZH2,FBXO32,FBXO36,HDAC11,HMGA1,HNRNPD,HSPA5,JUN,LGR5,MAD2L1,NR1H3,PRKDC,PROM1,PTPRO,SKP2,SLC16A1,TAF1D,TNFRSF10A,TRIM63,XPO1,YBX1 | 623 (20) |
| Tgf beta | NA | group | NA | 1.72e+00 | 0.0e+00 | ABCD1,ANGPTL4,ARID1B,ARID3A,ASCL2,ATOH8,BAMBI,BHLHA15,BHLHE40,CCL5,CCND1,CCNE1,CDKN1A,CTF1,CXCL10,Cxcl3,EGR2,EPAS1,FSCN1,GADD45B,GREM1,HES6,HTATIP2,ID3,ID4,ITGA2,ITGA5,ITGAV,JARID2,JUN,LOX,MAD2L1,MAFK,MDFI,MERTK,MMP15,MYCN,NCOA2,NEDD9,NEK3,NQO1,NR4A2,PDGFB,PLAT,PLPP3,PMEPA1,PRMT1,PROM1,RORA,SCLY,SDC1,SERPINE1,SERPINH1,SIM1,SKIL,SREBF1,TFEB,TFRC,THBS1,TIMP3,TLR2,TMEM252,TNFSF10 | 784 (18) |
| troglitazone | NA | chemical drug | NA | 1.72e+00 | 0.0e+00 | ADRB3,AGER,AGT,ANGPTL4,AQP3,ARF4,AXIN2,BAD,CARS1,CAV1,CAV2,CCL5,CCND1,CD86,CDC25A,CDKN1A,CEP135,CEP70,CIDEC,CXCL10,CXCL11,DGAT1,DHRS3,E2F4,ECT2,FOSL1,GADD45A,GPAM,HMMR,HSPA5,ICAM1,IFI16,JUN,KLF4,LEP,NAGK,NDRG1,NR1H3,NR4A3,P4HA1,PCNA,PDE3B,PEX11A,PLIN4,RGS10,SCARB1,Scd3,SDC1,SERPINE1,SKP2,SLC39A10,TGIF2,TMPRSS4,TWF2,UCP2,UCP3,USP18 | 741 (21) |
| SN-38 | NA | biologic drug | NA | 1.71e+00 | 1.0e-02 | BAD,BIRC2,CDKN1A,CHEK2,CHRNA9,HK2,PARP1,PPRC1,RAD51 | 525 (11) |
| Eldr | NA | other | NA | 1.71e+00 | 5.0e-02 | AURKA,BLM,EME1,HMMR,KIF18B,MYBL2,PLK1,UBE2C,ZWINT | NA |
| hexachlorobenzene | NA | chemical toxicant | NA | 1.71e+00 | 5.0e-02 | ASNS,Bex2/LOC100912195,Ctla2a,FXYD5,GTPBP4,IER3,LAMC2,TSPAN8,UPP1 | NA |
| imatinib | NA | chemical drug | NA | 1.70e+00 | 0.0e+00 | ARID3A,ATP2C1,AURKA,BCAT1,BCL2L11,BIRC2,BMP7,CCND1,CCNE1,CDKN1A,CHD1,CXCL10,DNAJB6,ECD,ECT2,EPAS1,GADD45A,HSPA2,HSPA5,Ifi47,Igtp,IRF1,ITGAX,LSM10,MAD2L1,MCM3,NCL,NHEJ1,NQO1,PCNA,PDIA4,PIK3R4,PLK1,POLD1,PPIF,RAD51,SKP2,SMPD1,SOCS2,STAT1,STAT3,TADA3,TFRC,TNFRSF10A,VAPA | 709 (21) |
| cardiotoxin | NA | chemical - other | NA | 1.70e+00 | 0.0e+00 | ADAM10,ANGPTL4,APOC2,CCL24,CCL5,Ccl6,CCND1,CCNE1,CSF2RB,CX3CL1,CXCL10,DLL1,ERFE,FGF11,FGF12,FGF7,FGF9,FLT3,GMNN,HSPA5,IL10RB,IL18,IL33,ITGA5,LTBP1,MCM3,MERTK,METRNL,MMP15,PCNA,PDGFB,SERPINB2,SERPINE1,STAT3,THBS1,TNFRSF10A,TSC22D1,TXNRD1,UCP2,UCP3,VEGFC | NA |
| NCF1 | 1.10e-01 | enzyme | NA | 1.70e+00 | 1.0e-02 | CCL5,CDKN1A,HYAL3,ICAM1,IFIH1,SERPINE1,STAT1,THBD | 630 (21) |
| THZ531 | NA | chemical drug | NA | 1.70e+00 | 5.0e-02 | ABCC4,ACSL3,ANKRA2,DEPTOR,FBXO36,ITGA2,LYRM7,NIPAL3,PAIP2B,PEX10,PMEPA1,SLFN5,SORBS2,TANGO6,TTC39B,TUBD1,ZNF839 | NA |
| cigarette smoke | NA | chemical toxicant | NA | 1.70e+00 | 0.0e+00 | ATF4,AXIN2,CCND1,CDKN1A,CKB,CXCL10,ELN,EPAS1,FBXO32,FOSL1,FTL,HSPA5,ICAM1,IRAK2,JUN,KLF4,LEP,LRAT,MAFF,MAP1LC3A,MAP2K3,Muc1,MX1,NQO1,NRG1,OAS2,Oasl2,OGG1,PDGFB,PDK2,PTPN1,RAMP2,RAPGEF3,SERPINE1,SREBF1,TRIM63,TXNRD1,WNT5A | 796 (20) |
| cis-urocanic acid | NA | chemical drug | NA | 1.69e+00 | 0.0e+00 | ADAMTS1,CD55,GADD45B,GLRX,HSPA1A/HSPA1B,PPIF,SERPINB2 | NA |
| USP18 | -1.00e+00 | peptidase | NA | 1.69e+00 | 0.0e+00 | BCL2L11,CCL5,CXCL10,IFIH1,IRF1,IRF7,IRF9,MX1,NFATC1,SOCS1,TNFSF10 | 318 (16) |
| TOX | -3.10e-01 | transcription regulator | NA | 1.67e+00 | 1.0e-02 | CDKN1C,CXCR3,EGR3,ID3,LEF1,NFIL3 | NA |
| betamethasone | NA | chemical drug | NA | 1.67e+00 | 1.0e-02 | CAV1,CRISPLD2,NQO1,SFTPB,TGM2,TIMP3 | NA |
| H2AB3 (includes others) | NA | other | NA | 1.67e+00 | 3.0e-02 | AQP3,BCL2L11,CDKN1A,CDKN1C,CHAC1,GAS1,HIP1R,ING1,LIPH | NA |
| CKAP2L | -1.00e-01 | other | NA | 1.67e+00 | 3.0e-02 | ERCC6L,MAD2L1,PLK1,PPP2R1B,TMPO,TUBB4B,TUBB6,UBE2C,ZWINT | NA |
| NKX2-3 | NA | transcription regulator | NA | 1.66e+00 | 0.0e+00 | ADAMTSL2,ANGPTL4,ASNS,CDKN1A,CX3CL1,DHX58,F2RL3,FBN2,GALNT15,GBP1,GCH1,GMPR,HELZ2,HMMR,KLF4,MAP2,NETO2,PARP14,PARP9,PAWR,PIM3,PKIA,PLA1A,PLSCR1,RNF213,RTP4,SLC25A28,SNCAIP,SP110,STAT1,STAT2,TNFSF18,TRIM21,UCP3,USP18,ZNFX1 | NA |
| FCGR2B | 4.00e-02 | transmembrane receptor | NA | 1.66e+00 | 5.0e-02 | CCL5,CD86,CXCL10,ICAM1,MARCKSL1,MX1,SOCS1 | NA |
| kainic acid | NA | chemical toxicant | NA | 1.66e+00 | 0.0e+00 | ATF4,CCL5,CCND1,CCNE1,CD200,CHGB,CNR1,DUSP1,EGR2,EGR3,FGF9,FOSL1,GADD45B,GFRA1,GJA1,GRIA3,IL18,JUN,LEF1,NFIL3,NPTX2,NR4A2,PCNA,PENK,PIM3,PLAT,RABEP2,RET,SDC1,SLC16A1 | 756 (24) |
| cocaine | NA | chemical drug | NA | 1.65e+00 | 0.0e+00 | BHLHE40,CNR1,CTU2,Dclk1,DUSP1,DUSP14,DUSP5,EFNB2,EGR2,FOSL1,FRMD6,GADD45A,GADD45B,GRIN1,ICAM1,JUN,LAMC2,mir-154,MX1,NOS1,NPTX2,NR4A3,PARP1,PDGFB,PITHD1,PLCXD1,PPRC1,RABEP2,STAT1,STAT2,TH,THBS1 | 704 (24) |
| indomethacin | NA | chemical drug | NA | 1.65e+00 | 0.0e+00 | ADAMTS1,ANGPT1,ASNS,Bex2/LOC100912195,CCND1,CD55,CD86,CDKN1A,CLDN4,CSF2RB,Ctla2a,DGAT1,FGF7,FXYD5,GTPBP4,HAS1,ICAM1,IER3,LAMC2,MCM3,NOS1,PCNA,PLA1A,PROM1,PTGDR2,RBM3,REN,SDC1,SLC7A5,TNFRSF21,TSPAN8,UCP2,UPP1,VCAN,VDR,XRCC6 | 784 (21) |
| 8-bromo-cAMP | NA | chemical reagent | NA | 1.65e+00 | 0.0e+00 | ACE,ACTG1,ACTN4,ADRB3,ARSB,BCAR1,BMP7,CAV1,CAV2,CCND1,CDKN1A,CDKN1C,CKB,CRYAA/LOC102724652,CSF2RB,DDB2,DIO2,DUSP1,EOGT,ESR1,F2R,FDX1,FGF9,FOSL1,FZD7,GCH1,GJA1,GNPTAB,GNRHR,HYAL3,ID3,ID4,IL12RB1,IL19,IL20,INHA,INHBB,ITGA11,ITGA2,ITGAV,JAK2,JUN,LAMB3,LEF1,LOX,LTBP1,MAD2L1,MANBA,MCM3,MCM4,MSH2,NFIL3,NFYA,NOS1,NQO1,P4HA1,PAK1,PCNA,PDE1A,PDE3B,PDE4A,PDE4B,PDE4D,PDGFB,PDGFC,PDGFD,PLAT,PLK1,PPP2R1B,PRKX,PTGFR,REN,RRM2,SCARB1,SERPINB2,SERPINE1,Slco1a4,SMPD1,SOCS1,STAT1,STAT3,TFCP2L1,TGFB2,TGFBR3,THBS1,TNC,VCL,VEGFC,WNT5A,WNT5B | 961 (26) |
| LMO2 | -2.60e-01 | transcription regulator | NA | 1.64e+00 | 0.0e+00 | ABCB10,ABL2,ANGPT1,ARID3A,AXIN2,BMP7,C8orf44-SGK3/SGK3,CDKN1A,CLDN4,COL18A1,CSTB,DHX58,DUSP22,F2R,GBP5,GJA1,GPRC5B,GRB10,HS1BP3,IFIH1,JARID2,KIFAP3,LEF1,MAP3K5,NDRG1,NLRX1,NPRL3,NT5E,Oasl2,PBX1,PLSCR1,RPL3L,SLC16A1,STAT3,STX7,SYNE2,TBX4,TGFB2,TLE6,TLR2,TNFRSF10A,TRAF1,VDR,ZMIZ1,ZNF518B | NA |
| LDB1 | 1.30e-01 | transcription regulator | NA | 1.64e+00 | 0.0e+00 | ABCB10,ABL2,ANGPT1,ARID3A,AXIN2,BMP7,C8orf44-SGK3/SGK3,CDKN1A,CLDN4,COL18A1,CSTB,DHX58,DUSP22,F2R,GBP5,GJA1,GPRC5B,GRB10,HS1BP3,IFIH1,JARID2,KIFAP3,LEF1,MAP3K5,NDRG1,NLRX1,NPRL3,NT5E,Oasl2,PBX1,PLSCR1,RPL3L,SLC16A1,STAT3,STX7,SYNE2,TBX4,TGFB2,TLE6,TLR2,TNFRSF10A,TRAF1,VDR,ZMIZ1,ZNF518B | NA |
| USF2 | 1.50e-01 | transcription regulator | NA | 1.64e+00 | 4.0e-02 | ACTN4,AGT,CFTR,EIF4E,GHRL,OPRD1,P4HA1,REN,SERPINE1,THBS1,UCP2 | NA |
| UHRF2 | -5.10e-01 | enzyme | NA | 1.63e+00 | 1.0e-02 | BCL2L11,CCNE1,CKB,CSE1L,FHDC1,NFKBIB | NA |
| Z36 | NA | chemical reagent | NA | 1.63e+00 | 2.0e-02 | ASNS,ATF4,CDKN1A,CHAC1,CREBRF,HSPA5 | NA |
| progestin | NA | chemical drug | NA | 1.63e+00 | 3.0e-02 | ARMT1,CCDC170,CCND1,ESR1,RMND1,ZBTB2 | NA |
| CEBPA | 4.10e-01 | transcription regulator | NA | 1.63e+00 | 0.0e+00 | ADRB3,AGT,AKR1B1,ANPEP,APLNR,AQP5,ASNS,ATF4,BIN1,CCND1,CDKN1A,EFNB2,EGR2,EIF4E,FZD1,GADD45A,GAL,GAS1,GBP1,GCH1,GJA1,GLRX,HDAC1,HDAC4,HMGA1,HNF1A,HSPA5,ICAM1,IER3,IRF6,ITGAX,JUN,KLF4,LEP,MAPKAPK2,MSI2,MYBL2,MYCN,NF2,NFATC1,NFIL3,NR1H4,NR4A2,OAS2,OLR1,OXTR,PCNA,PCSK6,PLXND1,PTGFR,RORA,S100G,SCGB3A2,SEMA3E,SERPINB2,SERPINE1,SFTPB,SFTPC,SREBF1,TGFB2,THBD,THBS1,TIAM1,TNFRSF10A,TNFSF10,TRIB1,TUBB2A,UBE2I,VCAN,VCL,VDR,ZMIZ1 | 685 (19) |
| CNTF | 2.80e-01 | cytokine | NA | 1.62e+00 | 0.0e+00 | ANGPT1,ATP6V1E1,CCL5,Ccl6,CCRL2,CISH,CLEC7A,CLIC4,CNR1,EGR2,FGF9,FXYD5,GJA1,GPR158,IFI16,IRF1,KLF4,LDB2,LEP,NFIA,Oasl2,OSMR,PDE10A,PDE1B,PENK,RPH3A,Scd2,SLC13A3,SLC16A1,SOCS1,SOCS2,SREBF1,STAT1,STAT3,TIMM9,TLR2,WNT5A | 612 (20) |
| lovastatin | NA | chemical drug | NA | 1.62e+00 | 0.0e+00 | ACAT2,ADAM10,ADAMTS1,ATF4,BCAR1,CCL5,CCND1,CD86,CDKN1A,CXCL10,ESR1,FDFT1,FGF9,HMGCS1,IRF1,KLF4,LEP,NFKBIB,NKX6-2,NRG1,PLAT,SERPINE1,SREBF1,TH | 682 (18) |
| SMAD3 | -2.60e-01 | transcription regulator | NA | 1.62e+00 | 0.0e+00 | ADAMTS1,ADORA1,ARID3A,ATF4,AXIN2,BCL2L11,CCND1,CCNE1,CDKN1A,COL2A1,CRISPLD2,CXCL10,DEPTOR,DGAT1,ELN,ESR1,FBN2,FDFT1,GADD45B,GNRHR,HSPA5,ID3,INHA,JUN,LOX,MMP19,NET1,PABPC4,PCNA,PDGFB,PMEPA1,POR,Scd2,SERPINE1,SFTPB,SKIL,STAT3,TGFB2,THBS1,TIMP3,TNC,TPSAB1/TPSB2,VCAN,VEGFC | 723 (19) |
| filgrastim | NA | biologic drug | NA | 1.61e+00 | 0.0e+00 | ACSL3,ANGPT1,ASCL2,CCL5,CD55,CD83,CDC42EP3,CEACAM1,CLEC4D,CLEC7A,CXCL10,DGKG,DPH5,EDARADD,EGR2,EGR3,EMILIN2,EPSTI1,EXT1,GADD45A,GBP1,GBP5,HHIP,HLTF,HMGA1,IFI44,IL1R2,IRAK4,IRF2BP2,ITPKC,JAK2,JARID2,JUN,KNL1,LAMB3,LEF1,LGALS12,MAFF,MERTK,MX1,MYO10,NLRP3,NR4A3,P2RY14,PARP14,PDE4B,PDE4D,PEX11G,PTGDR2,RNF43,SLC26A6,SLC45A3,SOCS1,SORD,SPON2,STAT1,TLR5,TNFRSF10A,TRERF1,TSC22D1 | NA |
| ASAH1 | -1.60e-01 | enzyme | NA | 1.60e+00 | 1.0e-02 | Acan,CCL5,COL2A1,ELOVL7,ITGA5,NR4A2,NR4A3,SCARB1,SMPD1 | 193 (7) |
| FGFR1 | 4.10e-01 | kinase | NA | 1.59e+00 | 0.0e+00 | Acan,BMP7,CCND1,CDKN1A,CRISPLD2,DLL1,DUS2,EIF3C,EIF4E,EIF5A,ELN,FGF7,HK2,HSPA5,JUN,LOX,NR1H3,PDGFB,TH,TNC | 711 (24) |
| PTPN3 | -2.20e-01 | phosphatase | NA | 1.59e+00 | 0.0e+00 | ANGPTL4,CDKN1A,ITGAV,PDGFB,SERPINE1,TGM2,VDR | 659 (18) |
| levodopa | NA | chemical - endogenous mammalian | NA | 1.58e+00 | 0.0e+00 | AMZ2,ARPP21,ATP2A2,ATXN1,BTBD3,CASK,CASZ1,CCND1,CD200,CDC42EP2,CDC42EP3,CHAC1,CLN6,CNR1,COQ8B,CRY2,DAAM1,DCAKD,DDIT4L,DLG2,DUSP1,EGR2,EIF6,EPHA5,EPOR,F11R,FOSL1,FTL,FXYD5,GADD45B,GPR158,GRB10,GRIN1,HNRNPL,HTATIP2,IER3,IPPK,KCNA5,KDM5B,LASP1,LDAH,LDB2,LINGO3,LRRC1,LTBP1,MSANTD1,MYO5B,NDUFA5,NOCT,NOMO1 (includes others),NPTX2,NT5E,Oasl2,Pakap,PALM,PENK,PINX1,PKIA,PKP2,PTBP1,RAPGEFL1,RBL2,REM2,RHBDL3,RILP,SATB1,SCN4B,SCUBE3,SKP2,SLC10A4,ST3GAL5,TCEANC2,TDRKH,TEX261,TH,TIAM1,TIAM2,TMEM63B,TRERF1,UBE3C,VAT1L,VGF,ZNF385B | 702 (17) |
| SP1 | 1.90e-01 | transcription regulator | NA | 1.57e+00 | 0.0e+00 | ABCC8,ADAMTS1,ADRA1D,AGER,Akr1b7,ASNS,ATM,ATP2A2,BMP7,CAV1,CCL5,CCND1,CD55,CDKN1A,CEACAM1,CKB,COL2A1,CPLX1,CXCL10,DDB2,EPOR,ESR1,F2R,FDX1,FOSL1,GEN1,GJA1,GLTP,GRIN1,HAS1,HDAC1,HDAC4,HK2,HMGA1,HSD17B7,HSPA5,ICAM1,ID4,IRF1,ITGA2,ITGAV,ITGAX,JUN,KLF4,Mt1,MYBL2,MYCN,NDRG1,NOS1,NPTXR,OGG1,OPRD1,PARP1,PDGFB,PDGFC,PENK,POLD1,PRKCB,PRKCD,PROCR,PROM1,PTPN1,RAD1,RAD54L,RNLS,RRM2,SCARB1,SERPINE1,SLC31A1,SLC5A1,SLC9A3,SMPD1,SOCS1,SREBF1,STAT1,STAT3,TCEAL1,TGFB2,TGFBR3,TGM1,THBD,TIMP3,TLR2,TNC,TNFSF10,TRIB1,TXNRD1,UGCG,VDR | 733 (21) |
| PPARG | -1.60e-01 | ligand-dependent nuclear receptor | NA | 1.56e+00 | 0.0e+00 | ADRB3,AGT,ANGPTL4,AQP3,ATP2A2,ATP4A,BIN1,CAV1,CAV2,CCL5,CCND1,CDKN1A,CIDEC,CTF1,Cxcl3,DGAT1,DHRS3,EPAS1,F11R,FOSL1,FZD1,GIPR,Gm12854/S100a11,GPAM,H6PD,HCAR1,HIVEP2,HK2,HSD3B7,ICAM1,IDH1,IL33,IRAK4,JUN,KLF4,LAMB3,LEP,LY6D,MANBA,MAP2,MBNL1,MUC13,NDRG1,NDUFA5,NPEPPS,NR1D1,NR1H3,OLAH,OLR1,OXR1,PACS1,PCNA,PDE3B,PEX11A,PLIN3,PLIN4,PPP2R2B,RAB20,REN,SCARB1,SCNN1G,SDC1,SERPINE1,SFTPB,SOCS1,SREBF1,TNFSF10,TRERF1,UCP2,UCP3,VDR,ZNF703 | 837 (23) |
| carbamazepine | NA | chemical drug | NA | 1.55e+00 | 0.0e+00 | ASNS,ATF4,BCAT1,DNAJB1,EIF4A1,HDAC5,MID1IP1,MTHFD2,OSMR,STAT3,STC2,UGT1A4 | 241 (7) |
| TREM1 | 2.70e-01 | transmembrane receptor | NA | 1.55e+00 | 0.0e+00 | ABL2,ACKR3,ACSL3,ASNS,ASPH,CCL5,CCRL2,CD83,CD86,CXCL10,DUSP14,EGR2,EGR3,ELOVL7,FOSL1,GADD45B,GEM,GIPR,GPRC5A,GREM1,HAS1,HSD3B7,IL15RA,IRF1,ITGAX,KCNJ2,LRFN4,MAD1L1,MAFF,MMP19,NFKBIB,NR4A2,NRIP3,NT5E,PLCXD1,PLPP3,SERPINB2,SNUPN,THBD,THBS1,TLR2,TMPO,WNT5A,YRDC | 722 (18) |
| agmatine | NA | chemical - endogenous mammalian | NA | 1.55e+00 | 3.0e-02 | BMP7,ICAM1,PCNA,UCP2,UCP3 | NA |
| FOXA1 | 4.00e-02 | transcription regulator | NA | 1.54e+00 | 5.0e-02 | AQP3,CDKN1A,CFTR,COL18A1,CXCL10,ELK3,ESR1,FMN1,GIPR,GREB1,HHIP,HNF1A,MSH2,NPTX2,NR4A2,PRDM15,RASSF1,RORA,SFTPC,SPDEF,TH | NA |
| IL1A | 7.40e-01 | cytokine | NA | 1.53e+00 | 0.0e+00 | ADAMTS1,ADAMTS4,ASIC1,BCL3,BIRC2,CCL5,CD83,CD86,CDKN1A,CXCL10,Cxcl3,F2RL3,FGF7,FOSL1,GBP1,GCH1,GNRHR,ICAM1,IER3,IL18,IL1R2,IL20,IRF1,ITGA5,ITGAV,JUN,LEP,LOX,PDGFB,RBL2,SERPINE1,SSTR1,STAT3,TERF2IP,TK1,TLR2,VEGFC,WNT5A | 543 (14) |
| AGT | 1.10e+00 | growth factor | NA | 1.53e+00 | 0.0e+00 | Acan,ACAT2,ACE,ADAMTS4,ADAMTSL2,Aff2,AGER,AGT,AKAP5,ANGPT1,ANGPTL8,ARID1B,ARID3A,ATP2A2,ATP2B2,BDKRB2,BHLHE40,C1QTNF1,CAV1,CCBE1,CCL5,CCND1,CCNE1,CCNF,CD86,CDC25A,CDKN1A,CDKN1C,CGREF1,CIT,CNR1,COL11A2,COL18A1,COMP,CRISPLD2,CSRP2,CTF1,CTRB2,CXCL10,DIO2,DUSP1,DUSP9,EDARADD,EFNB2,ELN,ESR1,ETV1,F2R,FDFT1,FDX1,FGF13,FGF16,FGF7,FGR,FOSL1,FOXP2,FZD1,FZD7,GCH1,GFOD1,GJA1,GREM1,GRIN1,HMGCS1,HSPA1A/HSPA1B,ICAM1,ID3,IDH1,IFI16,IL18,INHBB,IRF6,IRF7,ITGA2,ITGA5,ITGAV,ITGAX,JUN,KCNJ2,KCNJ8,KLF4,L1CAM,LEP,LIPG,LIPH,LOX,LSS,LTBP1,MAD2L1,MAP1LC3A,MAP2,mir-154,NCL,NDRG1,NLRP3,NOS1,NPTX2,NR4A2,NRG1,OLR1,PARP1,PAWR,Pcdh10,PCYOX1L,PDGFB,PDGFC,PDGFD,PKP2,PNLIPRP2,PROM1,PTBP2,PTGFR,RAD51,RELT,REN,SATB1,SCARB1,SCNN1A,SCNN1B,SCUBE3,SDC1,SERPINB2,SERPINE1,SLC5A1,SLC9A3,SOCS1,SPINT1,STC2,TFRC,TGFB2,TH,THBD,THBS1,TIAM1,TIMM9,TNC,TTC7A,TTPA,UCP2,UGCG,VEGFC,WNT5B | 808 (18) |
| mir-155 | NA | microRNA | NA | 1.53e+00 | 4.0e-02 | ADAM10,CCL5,CCND1,CDKN1A,CXCL10,DNAJB1,DUSP5,HK2,IRF7,IRF9,JARID2,MLH1,MSH2,MX1,RORA,SERPINE1,SOCS1,STAT1,STAT3 | NA |
| TNFSF14 | 2.60e-01 | cytokine | NA | 1.52e+00 | 5.0e-02 | CCL5,CD86,CXCL10,CXCL11,ICAM1,LIPC,NT5E | NA |
| TNF | -1.50e-01 | cytokine | NA | 1.52e+00 | 0.0e+00 | Acan,ACE,ACKR3,ACSL3,ADAMTS4,ADORA1,ADRB3,AGER,AGT,AKR1B1,ALS2CL,ANGPT1,ANGPTL4,ANPEP,ANXA11,APOC2,AQP3,AQP5,ARF4,ARHGAP18,ARHGEF10,ARHGEF6,ASCL2,ATF4,ATP2A2,AXIN2,B4GALNT1,BAMBI,BCL2L11,BCL3,BDKRB2,BHLHE40,BIRC2,BLVRA,BMPER,BTBD3,BTG3,C1QTNF1,CABP1,Casp12,CAV1,CCL24,CCL5,Ccl6,CCND1,CCNE1,CCRL2,CD200,CD55,CD83,CD86,CDC42EP2,CDKN1A,CFTR,CIDEC,CISH,CLDN4,CLIC4,COL2A1,CRISPLD2,CRY1,CSF2RB,CX3CL1,CXCL10,CXCL11,Cxcl3,CXCR3,CYP27B1,DEPTOR,DGAT1,DHRS3,DOCK8,DUSP1,DUSP14,DUSP5,DUSP9,E2F4,EFNB2,EGR2,EGR3,EHD1,ELK3,ELOVL7,EPOR,ESR1,ETV6,EXT1,F11R,F2RL3,FADS1,FBXO32,FMO1,FOSL1,FRMD6,FSCN1,FUT7,GADD45A,GADD45B,GBP1,GBP4,GCH1,GEM,GHRL,GJA1,GNA15,GPAM,GPRC5B,GREM1,GSDMD,GTDC1,HAS1,HDAC1,HK2,HMMR,HSD17B7,HSPA1A/HSPA1B,HSPA5,ICAM1,ID3,IDE,IER3,IFI16,IFI35,IFIH1,IL12RB1,IL15RA,IL18,IL19,IL1R2,IL20,IL33,INHA,IRAK2,IRF1,IRF7,IRF9,ISG20,ITGA2,ITGA5,ITGAV,ITGAX,JARID2,JUN,JUP,KCNH2,KCNJ1,KCNJ2,KLF4,LAMB3,LAMC2,LEP,LGALS12,LGR5,LOX,LSS,LY6D,MAFF,MAP2K3,MAP3K14,MARCKSL1,MCM3,MEFV,MERTK,METRNL,MSH2,Mt1,MX1,MYBL2,NCOA2,NEDD9,NET1,NFATC1,NFKBIB,NLRP3,NLRX1,NOCT,NOS1,NQO1,NR0B2,NR1H3,NR1H4,NR4A2,NR4A3,NRIP3,NUAK2,OAS2,OLFML2B,OLR1,OSCAR,OSMR,P2RX5,P3H2,PARP1,PARP14,PCNA,PCSK6,PDE4B,PDGFB,PDIA4,PENK,PEX11A,PIM3,PLA1A,PLAT,PLEKHG1,PLIN4,PLPP3,PLSCR1,PML,PNPLA1,PPIF,PPP2R1B,PRKCD,PRKDC,PROCR,PTGFR,PTPN1,PTPRN,RABEP2,RAPGEFL1,RFX2,RGS3,RGS7,RGS9,RND1,RNF149,RORA,RRM2,SAMD4A,SCARB1,SCNN1A,SCNN1B,SCNN1G,SCUBE2,SDC1,SEC61A1,SERPINB2,SERPINE1,SFTPB,SFTPC,SH3TC2,SLC14A1,SLC5A8,SLC7A11,SLC9A3,Slco1a4,SMPD1,SOCS1,SOCS2,SREBF1,SSTR1,ST3GAL5,STAT1,STAT2,STAT3,TERF2IP,TFRC,TGFB2,TGM2,TH,THBD,THBS1,TIAM2,TIMP3,TINAGL1,TK1,TLR2,TLR3,TLR5,TNC,TNFRSF10A,TNFRSF21,TNFSF10,TNIP1,TPT1,TRADD,TRAF1,TRIM15,TRIM63,TXNRD1,TYK2,UCP2,UCP3,UGCG,VASH1,VCL,VDR,VEGFC,WNT5A | 830 (19) |
| PTGER4 | 2.30e-01 | G-protein coupled receptor | NA | 1.51e+00 | 0.0e+00 | ADAMTS4,APOC2,CXCL10,GBP4,ICAM1,IFI16,IFI35,Ifi47,IFIH1,Igtp,IL18,IRF1,IRF7,Irgm1,ISG20,MAFF,Oas1b,OLR1,PARP14,PDGFB,PDK2,RNF213,RTP4,SAP30,Serpinb6b,SLC13A3,SLFN13,SLFN5,STXBP4,TNFSF10,TRIM21,USP18 | 722 (16) |
| SYVN1 | -5.00e-02 | transporter | NA | 1.51e+00 | 0.0e+00 | ABCC4,ACSL3,BCAT1,BHLHE40,CCND1,DIO2,DUSP1,EXT2,FANCG,GPRC5A,IFI44,IL18,IRAK2,ITGAV,L1CAM,MYOF,OLR1,PLD2,PLPP3,PNPLA2,PTBP1,SLC16A1,SLC30A1,SLC39A10,SLC3A2,SLC7A5,TFRC,TRERF1 | 465 (7) |
| Mek | NA | group | NA | 1.51e+00 | 0.0e+00 | ANPEP,B4GAT1,BCL2L11,CCND1,CD200,CDCP1,CDKN1A,CEBPZ,CPM,CXCL10,CXCL11,DDR1,DSCC1,DUSP5,EGR2,EGR3,EPAS1,ESR1,ETV1,EXT1,EXT2,FOSL1,FUT10,GNL3,ICAM1,IER3,Ifi47,IRF1,ITGA2B,JUN,L1CAM,LAMB3,LAMC2,LEP,MAFF,NOP58,NQO1,NR1H3,NT5E,PLPP3,POMK,PPAT,SDC1,SEMA4C,SERPINE1,SLC6A14,THBS1,TSPAN1,VEGFC | 740 (22) |
| HGF | 1.10e-01 | growth factor | NA | 1.51e+00 | 0.0e+00 | ACKR3,ADAMTS1,ADGRF5,ANGPT4,ANGPTL4,ASNS,ATM,AURKA,BIRC2,CA9,CAV1,CCL5,CCND1,CCNF,CDC25A,CDKN1A,CGRRF1,COL2A1,CRY1,CSE1L,DDX11,DUSP1,EFNB2,FANCG,FGF16,FGF7,FOSL1,GEM,GMNN,GRB10,GRB14,HDAC5,HK2,HMMR,ICAM1,IER3,IL15RA,ISG20,ITGA2,JUN,L1CAM,LAMC2,MAD2L1,MAP2K3,MAPKAPK2,MERTK,MPHOSPH10,NCOA2,NEK3,NFATC1,NR0B2,NR4A2,NR4A3,NRG1,OSMR,PCNA,PEX5,PLK1,PLPP3,PNRC1,PPAN,PRC1,PRKDC,SERPINB2,SERPINE1,SKIL,SKP2,SMC2,SOCS2,SSTR1,TGFB2,THBD,THBS1,TIMP3,TRIB1,UBE2C,VDR,VEGFC | 789 (22) |
| SS18 | -2.30e-01 | transcription regulator | NA | 1.51e+00 | 0.0e+00 | BCL2L11,CABP7,DLL1,DUSP9,GADD45B,GCH1,METRNL,NFATC1,PDGFB,RET,SOX8 | NA |
| prostaglandin D2 | NA | chemical - endogenous mammalian | NA | 1.51e+00 | 1.0e-02 | CCL5,CCND1,CXCL10,EDARADD,EPAS1,HAS1,HSPA1A/HSPA1B,NFATC1,PRKCD,SOX8,VDR | NA |
| ARNT | -5.20e-01 | transcription regulator | NA | 1.51e+00 | 0.0e+00 | ANGPTL4,BAMBI,BHLHE40,CA9,CAV1,CDCP1,CXCL10,CXCR3,EIF6,EPAS1,GADD45B,GAS1,HES6,HK2,HNF1A,IL1R2,ITGAV,LEP,NQO1,OAZ1,PPP2CB,SERPINE1,SIM1,SOCS2,TFRC,UBE2C | 745 (20) |
| PRDM1 | 5.00e-02 | transcription regulator | NA | 1.50e+00 | 0.0e+00 | ANGPTL4,AQP3,ATG7,AXIN2,BCL2L11,BHLHA15,CA9,CASZ1,CD86,CEP112,CRISPLD2,EGR2,ESR1,EVA1A,EZH2,FGR,FOSL1,ICAM1,ID3,IRF2BP2,IRF7,LAT,MAP3K5,NFATC1,NLRP3,OAS2,PCSK6,PIK3AP1,PRKDC,PROX1,RAPGEF3,SLC2A5,SLC5A8,SOCS2,SOX8,SRD5A1,STAT1,TNFSF10,TRIB1,VSX2 | 664 (24) |
| butylated hydroxyanisol | NA | chemical toxicant | NA | 1.49e+00 | 3.0e-02 | HNF1A,IRF1,IRF7,JUN,NQO1,NR0B2,SCARB1 | NA |
| 3,4,5,3’,4’-pentachlorobiphenyl | NA | chemical toxicant | NA | 1.49e+00 | 1.0e-02 | ESR1,FGF9,GADD45A,GRIN1,HSPA1A/HSPA1B,HSPA2,IDH1,JUN,NQO1,NR0B2,PTGFR,Slco1a4,SOCS2,TNC | NA |
| VEGFB | -2.90e-01 | growth factor | NA | 1.49e+00 | 5.0e-02 | ATP2A2,BAD,BCL2L11,Casp12,DIO2,MSS51,OLR1,TXNRD1,TXNRD3 | NA |
| Ige | NA | complex | NA | 1.48e+00 | 0.0e+00 | AQP3,ATP2A2,BAIAP2,BCAT1,BCL2L11,BCL3,CARD11,CAV1,CCL24,CCL5,CD86,CDK19,CDKN1A,CEACAM1,CISH,CLEC7A,COL18A1,CX3CL1,EGR2,F2R,GADD45B,HEATR1,HIP1R,ICAM1,IER3,IL33,ITGA5,ITGAV,ITGAX,JAK2,LAMA5,MAPKAPK2,MARCKSL1,NFATC1,NFKBIB,NPHS2,PDGFB,PENK,PPAN,PPIF,PPP1R3B,PPP3CC,RAB7B,RAI14,RFX2,RHOD,RILP,SCARB1,SERPINB2,Serpinb6b,SOCS1,TFRC,TLR2,TNC,TNFRSF10A,TNFSF10,TRAF1,TUBB6,UGCG,VDR,VEGFC | 727 (16) |
| mir-21 | NA | microRNA | NA | 1.48e+00 | 0.0e+00 | ARF4,ARF6,ATAD2,C8orf44-SGK3/SGK3,CAMKK1,Casp12,CD86,CDC25A,CDKN1A,CLDND1,CSE1L,CSNK2A2,CXCL10,Cxcl3,DHX58,ECT2,EGR2,ELN,GBP5,ICAM1,IFI16,Ifi47,IL18,IRF1,Irgm1,JAK2,Klrk1,Ldha/RGD1562690,MSH2,NIFK,NLRP3,NUSAP1,OAS2,PLAT,PPP1R3B,PRC1,RAB7B,SMC2,SOCS1,STAT1,STAT2,STAT3,STRAP,TGM1,TIAM1,TIMP3,TLR2,TRAF1,TRIM37,TRMT10C,UBE2G1,VRK1 | 658 (17) |
| BTRC | 2.70e-01 | enzyme | NA | 1.46e+00 | 3.0e-02 | AXIN2,CCND1,CDKN1A,CHD1,DEPTOR,TRAF1 | NA |
| KITLG | -2.20e-01 | growth factor | NA | 1.46e+00 | 3.0e-02 | BCL2L11,BZW2,CCNE1,CDKN1A,CISH,CPSF3,CX3CL1,EFNB2,EPOR,F2R,GJA1,GNAZ,IL18,ITGA2B,ITGAV,MID1IP1,OGG1,ORAI1,PDGFB,PLSCR1,PRKCB,RNF128,SMARCD2,SOCS1,STAT3,Tpm4,TPSAB1/TPSB2,TPT1,UCP2,UGCG,XRCC4 | NA |
| SRA1 | -5.00e-02 | transcription regulator | NA | 1.45e+00 | 3.0e-02 | CAV1,DIO2,PRDM16,TGFB2,THBS1 | NA |
| Ngf | NA | group | NA | 1.44e+00 | 0.0e+00 | BAD,BCL2L11,CCND1,CDKN1A,CHGB,DIO2,DUSP1,JUN,MAP2,MAP6,MYBL2,NOS1,NR4A2,SERPINE1,TGFB2,TH,TRPV1,VGF | 742 (22) |
| bafilomycin A1 | NA | chemical drug | NA | 1.44e+00 | 2.0e-02 | Akr1b7,CD83,CFTR,CXCL10,KCNA5,KCNH2,NR0B2,TFRC,TNFRSF10A | NA |
| methylselenic acid | NA | chemical reagent | NA | 1.43e+00 | 0.0e+00 | ABCC4,ACKR3,ACSL3,ACTN4,ADAMTS1,ATAD2,AURKA,BIRC2,CCND1,CDC25A,CDK2AP2,CDKN1A,CDKN1C,CHEK2,ESR1,GADD45A,HMMR,ID3,ING1,INPP4B,IRF1,JUN,KLF4,KLHL2,MAP2K3,MAP2K5,MCM3,MYBL2,NAT2,NDRG1,NFIL3,NQO1,PCNA,PDIA4,PLK1,POLA1,POLE2,PRIM2,RAD9A,RAPGEF4,RGS10,RRM2,STX7,TAF6,TGFBR3,TLR2,TUBB4B,VEGFC | 773 (18) |
| ethanol | NA | chemical - endogenous mammalian | NA | 1.42e+00 | 0.0e+00 | ACKR3,ANPEP,ASCL2,ASPH,ATF4,AXIN2,BAD,Bmp8b,CCL5,CCND1,CDKN1A,CLIC4,CNR1,CPOX,DUSP1,EIF6,ESR1,EZH2,FOSL1,GADD45A,GDE1,GPAM,GRIN1,HSPA5,HTATIP2,ICAM1,Ifi47,IL18,IL1R2,IL33,IRF7,ITGAX,JAK2,JUN,KLF4,LSS,MAP1LC3A,MAP2,Meis1,mir-154,MYCN,MYOF,NQO1,NT5E,OPRD1,PARP1,PCNA,PDLIM5,PLAT,PNPLA2,PROM1,PRPF19,RORA,RRP12,RRS1,SERPINE1,SLC7A11,SREBF1,STAT1,STAT3,TFCP2L1,TGFB2,TGM2,TLR2 | 750 (22) |
| cuprizone | NA | chemical toxicant | NA | 1.42e+00 | 1.0e-02 | ABCD1,ALPK1,CCL5,CD86,CXCL10,FAM78A,FDFT1,GNPDA1,HMGCS1,HSPH1,KLHL40,LCP1,LEF1,MPP2,NLRP3,NT5DC3,PLEKHD1,PRKCD,PTBP1,SLC31A1,TFRC,TGM1 | 246 (7) |
| Gsk3 | NA | group | NA | 1.42e+00 | 2.0e-02 | Acan,ATF4,BCL2L11,CCND1,COL2A1,ESR1,FSCN1,ICAM1,JUN,NR4A2,SREBF1,STAT1,TBX6 | NA |
| l-asparaginase | NA | biologic drug | NA | 1.42e+00 | 0.0e+00 | ASNS,AURKA,CDKN1A,ERCC6L,HMGCS1,KIF18B,KNL1,LIPG,MAD2L1,MCM3,MCM4,MIS18BP1,MTHFD2,MYBL2,PLK1,POLE2,RAD51,RAD9B,SMC2,UBE2C | NA |
| CpG oligonucleotide | NA | chemical drug | NA | 1.42e+00 | 0.0e+00 | CA9,CD83,CD86,CLEC4D,CSE1L,CXCL10,DUSP1,ELOVL5,ICAM1,IL18,IL33,IRF7,ITGAX,Oas1b,OAS2,Oasl2,OLR1,PCNA,PRKCD,RRM2,SDC1,SERPINE1,SLC6A4,SLC7A5,STAT2,TFRC,THBS1,TLR2,TNFSF10 | 574 (19) |
| CCL5 | 7.40e-01 | cytokine | NA | 1.42e+00 | 1.0e-02 | ATF4,CCL5,CCRL2,DUSP1,F2R,HMGA1,MMP19,OLR1,PPIF,SERPINB2,STAT1,STAT3,THBS1,TUBB4B | 728 (19) |
| arsenic trioxide | NA | chemical drug | NA | 1.41e+00 | 0.0e+00 | ACAT2,ARID3A,ATF4,ATP2C1,AURKA,BAD,BCAT1,BLVRA,CCND1,CDKN1A,DNAJB6,ECD,ECT2,EPAS1,FADS1,FDFT1,FDX1,GLRX,HMGCS1,HSPA2,HSPA5,IRF1,LSS,MCM3,NCL,NQO1,PCNA,PDIA4,PIK3R4,PML,POLD1,PPIF,PRAM1,SHMT1,SKIL,SLC7A11,SREBF1,STAT3,TADA3,TFRC,TNFRSF10A,TXNRD1,VAPA,VDR | 781 (25) |
| EIF2AK4 | 2.30e-01 | kinase | NA | 1.41e+00 | 1.0e-02 | ASNS,ATF4,ATG7,ATP2A2,CHAC1,CIDEC,DGAT1,NQO1,PARP1,SCARB1 | NA |
| PRKAA | NA | group | NA | 1.41e+00 | 5.0e-02 | CCND1,CDKN1A,CXCL10,DUSP1,HDAC4,OGG1,SREBF1,STAT1,YBX1 | NA |
| APEX1 | -9.00e-02 | enzyme | NA | 1.40e+00 | 2.0e-02 | ABCB10,CDKN1A,EGR2,EGR3,GFRA1,NCL,NPTX2 | NA |
| cephaloridine | NA | chemical drug | NA | 1.39e+00 | 2.0e-02 | AMPD1,ANGPTL4,CCNE1,CXCL10,DSCC1,HSPA1A/HSPA1B,HSPH1,KCNH1,LAMB3,MCM3,NQO1,OSMR,RND1,SCGB3A2,TFRC | NA |
| FOS | 4.60e-01 | transcription regulator | NA | 1.39e+00 | 0.0e+00 | ACTG1,AGT,AQP3,ARID3A,ATF7IP,ATP2C1,BCL2L11,CASZ1,CCL5,CCND1,CCNE1,Ccnjl,COL18A1,CXCL10,DIO2,EGR2,EPAS1,ERCC5,Fhod1,FMN1,FOSL1,GAS1,GJA1,GNRHR,GREB1,HAS1,HK2,HMMR,HOOK1,HSPA5,HSPB8,HTATIP2,ICAM1,IFI16,ITGA2,JUN,LAMB3,Ldha/RGD1562690,LOX,LTBP1,MAFK,MLH1,MYO5B,NET1,NFATC1,NFIL3,NPTX2,NQO1,NR1H3,OXTR,PENK,PLAT,PMEPA1,PTP4A1,PTPRN,PTPRO,RAPGEF3,RIPK4,RPL9,RPS18,SDC1,SEMA3E,SERPINB2,SERPINE1,SMARCD2,STX11,TH,Tpm4,UGCG,VEGFC,WNT5A | 763 (21) |
| KRIT1 | -2.70e-01 | other | NA | 1.39e+00 | 0.0e+00 | EFNB2,JUN,KLF4,TGFB2,THBS1 | NA |
| FLT1 | NA | kinase | NA | 1.39e+00 | 1.0e-02 | ACTN4,AHCY,APLNR,BCAT1,CDKN1A,CLIC4,COL2A1,EIF5A,EPAS1,ICAM1,PTBP1,RDX,THBS1,TNIP1 | NA |
| doxycycline | NA | chemical drug | NA | 1.39e+00 | 1.0e-02 | ASNS,CD86,CHAC1,E2F4,EGR2,FGF7,HSPA1A/HSPA1B,IRAK4,ITGAX,L1CAM,MAP3K5,SDC1,SOCS1,SOX11,TLR2 | NA |
| GHRH | 4.00e-02 | other | NA | 1.39e+00 | 0.0e+00 | CCND1,CCNE1,GHRL,LEP,PCNA,RAPGEF3,SSTR1,TRIM63 | 710 (25) |
| VitaminD3-VDR-RXR | NA | complex | NA | 1.37e+00 | 0.0e+00 | CCL5,CDKN1A,CXCL10,CYP27B1,GADD45A,KLF4,S100G,TGFB2,THBD,TRPV6 | NA |
| nickel chloride | NA | chemical toxicant | NA | 1.37e+00 | 3.0e-02 | ATF4,EPAS1,GLRX,HSPB8,JUN,Ldha/RGD1562690,MAFF,NDRG1,P4HA1,TXNRD1 | NA |
| leukotriene D4 | NA | chemical - endogenous mammalian | NA | 1.36e+00 | 1.0e-02 | ADAMTS1,DUSP1,EGR2,EGR3,GEM,KCNJ2,KLF4,NDRG1,NEDD9,NR4A2,NR4A3 | 645 (17) |
| epigallocatechin-gallate | NA | chemical drug | NA | 1.36e+00 | 0.0e+00 | ADAM10,ANGPT1,BAD,BIRC2,CCL5,CCND1,CDKN1A,COL18A1,CXCL10,ESR1,FOSL1,GADD45A,GADD45B,GBP4,GJA1,ICAM1,Ifi47,IL18,IRF1,ITGAV,JUN,JUP,LEP,MAP3K5,NFATC1,NOS1,NR4A2,PCNA,PDIA4,SERPINE1,SLC16A1,SLC5A1,SOCS1,STAT1,STAT3,TFRC,TNFRSF10A,TNFSF10,TOLLIP,TRAF1,VEGFC | 700 (15) |
| SPIB | -2.90e-01 | transcription regulator | NA | 1.34e+00 | 0.0e+00 | CCL24,CD200,Cd209d,CD86,CLEC10A,Col17a1,COL2A1,DLL1,EGR2,GEM,GNA15,HSPA1A/HSPA1B,IL18,LGR5,MBD2,NET1,RAD51,TCEANC2 | NA |
| GPR174 | -3.30e-01 | G-protein coupled receptor | NA | 1.34e+00 | 3.0e-02 | ARAP2,BCL2L11,BCL3,CARD11,CD200,CD86,FCHSD2,GFOD1,IFI16,ISY1-RAB43,PDE3B,PDE4B,SATB1,STAT3,UGCG | NA |
| terbutaline | NA | chemical drug | NA | 1.34e+00 | 0.0e+00 | AQP5,LEP,REN,SCNN1B,SCNN1G,SFTPB | 250 (7) |
| TNFAIP2 | -3.70e-01 | other | NA | 1.34e+00 | 1.0e-02 | IL15RA,IRF1,ISG20,MERTK,PLAT | NA |
| dexamethasone phosphate | NA | chemical drug | NA | 1.34e+00 | 5.0e-02 | Arrdc2,DUSP1,ID3,Mt1,THBS1 | NA |
| EGR1 | 5.80e-01 | transcription regulator | NA | 1.34e+00 | 0.0e+00 | ACE,ATP2A2,BAIAP2,BCAR1,BCL2L11,CAV1,Ccl6,CCND1,CDKN1A,CHGB,COL2A1,EGR2,EZH2,FOSL1,FTL,GADD45A,GADD45B,GALNT3,ICAM1,JUN,LEP,NDRG1,PDGFC,PNPLA2,PTPN1,SERPINE1,SLC12A5,SOCS1,TH,THBS1,TIAM1,TNFSF10 | 853 (23) |
| S100A9 | -1.30e-01 | other | NA | 1.34e+00 | 0.0e+00 | ADAMTS1,ADAMTS4,BCL3,BHLHE40,CCND1,CPM,CSF2RB,CSTF1,CXCL10,ELN,FOSL1,GPRC5A,ICAM1,IL33,LTBP1,NR1H4,NR4A3,NRG1,OLR1,PDGFC,PTPRO,RAB20,SDCBP2,SLC26A1,USP18,VCAN,VGF | 742 (23) |
| Ca2+ | NA | chemical - endogenous mammalian | NA | 1.33e+00 | 0.0e+00 | Acan,AGER,AQP5,ATP2A2,CCND1,CCNE1,CD83,CD86,CDKN1A,CHGB,COL2A1,CRY1,CYP27B1,DUSP1,FOSL1,GJA1,GUCY1A2,HSPA5,ICAM1,ID3,IL33,IRF1,JUN,KLF4,MMP19,NDRG1,NFATC1,NOS1,NR1D1,NR4A3,ORAI1,OSCAR,PNPLA1,S100G,SCARB1,SERPINB2,SERPINE1,TGM1,TRPV6,UGCG,VDR | 816 (23) |
| mirdametinib | NA | chemical drug | NA | 1.33e+00 | 0.0e+00 | BCL2L11,CYP27B1,DEPTOR,ETV1,KLF4,MERTK,TFCP2L1,TFRC,TNFRSF10A | NA |
| TRAF3IP2 | -1.70e-01 | enzyme | NA | 1.33e+00 | 4.0e-02 | ACE,AGER,AGT,CCL24,CCL5,CX3CL1,CXCL10,ICAM1,IL18,IL19,IL33 | NA |
| GFI1 | -1.80e-01 | transcription regulator | NA | 1.33e+00 | 0.0e+00 | ATF1,BCL3,CDKN1A,DDB2,DGKG,EGR2,F2R,GJA1,HDAC4,ICAM1,IRAK2,IRF1,JUN,KAT2B,MAFF,MAP3K5,MAP4K5,NT5E,RAPGEF4,RASL11B,SLFN13,STAT1,TOLLIP,TRADD,VDR | 540 (17) |
| THBS4 | -1.50e-01 | other | NA | 1.32e+00 | 1.0e-02 | ATF4,COL2A1,CXCL10,HSPA5,ICAM1,MTHFD2,TGFB2,TNC | 619 (16) |
| ZNF768 | -7.00e-02 | other | NA | 1.32e+00 | 0.0e+00 | AURKA,EZH2,GADD45A,ICAM1,MYBL2,NUSAP1,PCNA,PLK1,PML,SERPINE1 | 537 (13) |
| E2F3 | 3.50e-01 | transcription regulator | NA | 1.31e+00 | 0.0e+00 | AKNA,BAIAP2L1,CAV2,CCND1,CCNE1,CDC25A,CDKN1A,COL18A1,CXCR3,EZH2,ID3,KRT80,LEP,MAD2L1,MCM3,MCM4,MLH1,MYBL2,MYCN,NCAPG2,NECTIN1,PCNA,PLK1,POLA1,RAD51,RRM2,SERPINE1,SERPINH1,THBD,THBS1,TIMP3,TK1,TMPO,UBE2C | 652 (20) |
| NR5A1 | 3.40e-01 | ligand-dependent nuclear receptor | NA | 1.31e+00 | 3.0e-02 | Akr1b7,GAL,GNRHR,INHA,LEP,NOS1,NR0B2,NR4A2,PCNA,SCARB1,TH | NA |
| 5-N-ethylcarboxamido adenosine | NA | chemical reagent | NA | 1.31e+00 | 0.0e+00 | ACKR3,BCL3,BHLHE40,CSF2RB,EGR2,FZD1,GADD45A,HK2,NFIL3,NR4A2,NR4A3,NT5E,PROCR,PROM1,RGS3,SERPINE1,SPINT1,THBD,THBS1,VCAN,VDR | 719 (22) |
| alvespimycin | NA | chemical drug | NA | 1.31e+00 | 5.0e-02 | CCND1,ESR1,FDFT1,HSPA1A/HSPA1B,SREBF1 | NA |
| EIF3E | NA | translation regulator | NA | 1.30e+00 | 0.0e+00 | ANGPT1,CCND1,CCNF,COL18A1,CORO1C,EIF3C,EIF3D,EPAS1,FARP1,MAD2L1,RAD54L,SMC2,THBS1,TNC,TOP3A | 539 (7) |
| TCF4 | -4.10e-01 | transcription regulator | NA | 1.30e+00 | 2.0e-02 | ANGPTL4,ARHGEF6,BHLHA15,BHLHE40,BMP7,CBLN2,CD55,CDKN1A,CDKN1C,FBXO4,FTSJ1,GEMIN6,GMPR,GRB14,HMMR,ID3,IFI16,JAK2,LY6D,MAD2L1,MPV17L,NEDD9,NIFK,PDIA4,PLPP5,PML,PPIF,PRC1,PUS3,RPS6KC1,RRM2,RRS1,SORBS2,STAT2,SURF6,TNFSF10,TRADD,TRMT10C,TSR1,TXNDC5,WDR12,ZNF467 | NA |
| lipid A | NA | chemical toxicant | NA | 1.29e+00 | 3.0e-02 | CCL5,CD86,CXCL10,ITGA5,OLR1,PRKCD,THBS1,TLR3 | NA |
| 2-deoxyglucose | NA | chemical drug | NA | 1.29e+00 | 0.0e+00 | ATF4,BCL2L11,BIRC2,CCL5,CCND1,CDKN1A,HK2,HSPA5,IRF7,JUN,LEP,LGR5,MYCN,NLRX1,SLC5A1,STAT1,TAS1R3,TOX2 | 793 (23) |
| TNFSF13B | -3.90e-01 | cytokine | NA | 1.27e+00 | 0.0e+00 | BCAR1,BCL2L11,CD200,CD83,CD86,DUSP5,ECT2,FGR,FLT3,FOSL1,ICAM1,JUN,LEP,MAGED1,MAP3K14,MEFV,MYBL2,NR4A2,PLK1,PLSCR1,PRDM16,RFFL,SOX11,THBS1,UNC5C,VDR | 780 (21) |
| methyl methanesulfonate | NA | chemical toxicant | NA | 1.27e+00 | 0.0e+00 | ATF4,CDKN1A,DDB2,EIF1,GADD45A,GADD45B,HSPA5,ISG20,JUN,KLF4,NFYA,OGG1,PHLDA3 | 707 (21) |
| metformin | NA | chemical drug | NA | 1.27e+00 | 2.0e-02 | AGER,ANGPTL4,ATF4,ATF7IP,Atp8b5,BAMBI,BCL3,CAV1,CCND1,CCNE1,CDKN1A,CIDEC,ENO3,GADD45B,GLP1R,GRB14,HMGCS1,HSPA5,IFI44,Ifi47,JAK2,KLHDC1,LEP,MX1,NR0B2,PARP14,PHLDA3,PPP1R3B,PROCR,SCARB1,SERPINE1,SREBF1,UCP2,ZFYVE19 | NA |
| celecoxib | NA | chemical drug | NA | 1.27e+00 | 4.0e-02 | ATF4,ATM,BIRC2,CCND1,CDKN1A,CLDN4,ESR1,GADD45A,HSPA5,ICAM1,PCNA,SERPINE1,TLR2,TNFRSF10A,TRAF1,VEGFC,WNT5A | NA |
| calcitriol | NA | chemical drug | NA | 1.27e+00 | 0.0e+00 | ABCB10,ABLIM1,ACAT2,AFAP1L2,AKR1B1,ATM,BCAT1,BCL3,BIRC2,BMP7,CA11,CCL5,CCND1,CCNE1,CDKN1A,CELSR3,CHTF18,CISH,CPOX,CSE1L,CXCL10,CYP27B1,DLL1,DUSP1,ECT2,EIF1,ELN,ESR1,EZH2,FAM107A,FBN2,FDX1,FTL,GADD45A,GEM,GLRX,GNPDA1,HAGH,HDAC1,HK2,IDH1,IER3,IFI44L,IL18,IRF7,ITGAX,JUN,KCNH1,KLF4,LEP,LILRB4,LTBP1,MAD2L1,MCM3,MCM4,MSI1,MX1,MYCN,NEDD9,NFATC1,NFKBIB,NPHS2,NUSAP1,OSCAR,OXR1,P3H2,PCNA,PDE4D,PDLIM2,PIK3AP1,PMEPA1,POLE2,POR,PPIF,PRC1,PRKCB,PRKCD,PTGFR,RAD51,REN,RRM2,S100G,SKP2,SLC14A1,SLC16A1,SLC30A1,SLC45A3,SLC7A7,SMC2,SPON2,SREBF1,STAT3,TGFB2,THBD,THBS1,TINAGL1,TK1,TLR2,TLR3,TNFSF10,TRPV6,UCP2,VCL,VDR,XPO1 | 790 (23) |
| KLF5 | 2.60e-01 | transcription regulator | NA | 1.27e+00 | 1.0e-02 | CCND1,CDKN1A,CGREF1,DUSP1,EGR2,EIF5A,EPAS1,ID3,JUN,LGR5,MAFF,NR1H4,PCNA,PDGFB,TRPV6,UCP2,UCP3 | 768 (25) |
| KLF11 | 8.00e-02 | transcription regulator | NA | 1.26e+00 | 2.0e-02 | ADAMTS1,AGT,BMP7,CAV1,CHRM1,DIO2,GREM1,ITGA2,ITGAV,LOX,LTBP1,PDGFB,PLAT,SERPINE1,SERPINH1,STAT1,TGFB2,THBS1,TIMP3 | NA |
| birabresib | NA | chemical drug | NA | 1.26e+00 | 0.0e+00 | ACKR3,ADAMTS1,BCAT1,CHRNA9,EFNB2,HSPA5,IFI44,IFI44L,LDB2,MYCN,NPTX2,PDE1A,PDLIM2,POLE2,RAI14,USP18 | 214 (3) |
| Ni2+ | NA | chemical reagent | NA | 1.25e+00 | 5.0e-02 | ANGPTL4,ASNS,CX3CL1,ICAM1,NDRG1 | NA |
| CAV1 | 6.80e-01 | transmembrane receptor | NA | 1.25e+00 | 0.0e+00 | ADAMTS4,ADGRG2,ATM,BCL2L11,CAV1,CAV2,CCND1,CCNE1,CD86,CDKN1A,CXCL10,ESR1,HK2,ICAM1,INHBB,LEP,NFATC1,NQO1,PCNA,PDK2,PROM1,SERPINE1,SKIL,SLC14A1,SRP54,THBS1,TNC | 660 (21) |
| PTHLH | NA | other | NA | 1.25e+00 | 1.0e-02 | Acan,ADAMTS1,ANGPT1,CCND1,CDKN1A,COL2A1,EFNB2,HSPA1A/HSPA1B,LEF1,S100G,SERPINE1,TGM1,TNC,VDR | 719 (23) |
| 1,1-bis(3’-indolyl)-1-(4-trifluoromethyl-phenyl)methane | NA | chemical reagent | NA | 1.24e+00 | 0.0e+00 | CAV1,CAV2,CDKN1A,TNFSF10 | 312 (7) |
| NR1H2 | 1.90e-01 | ligand-dependent nuclear receptor | NA | 1.23e+00 | 2.0e-02 | ACE,AGT,CCL5,CXCL10,DIO2,FDFT1,GBP4,ITGAX,NR1H3,PNPLA2,PRDM16,REN,SCARB1,Scd2,SREBF1,VEGFC | NA |
| AKT1 | -2.20e-01 | kinase | NA | 1.23e+00 | 2.0e-02 | Acan,ACAT2,ATP6V1E1,BAD,BCL2L11,CCL5,Ccl6,CCND1,CCNE1,CD86,CDKN1A,CISH,CXCL10,ESR1,FBXO32,FXYD5,HMGCS1,HNRNPL,LEP,LSS,NFATC1,NQO1,PEX11A,PROM1,REN,SERPINE1,SLC3A2,SREBF1,TGFB2,TGFBR3,THBS1,TK1,TNFSF10,TRIM63,UBE2C,VCAN,ZWINT | NA |
| phenylephrine | NA | chemical drug | NA | 1.23e+00 | 1.0e-02 | ANGPT1,ATP2A2,DIO2,DUSP1,E2F4,GJA1,HSPA5,JUN,MAP1LC3A,NRG1,PRKCB,RAPGEF3,REN,STEAP3,TFEB | NA |
| Nfat (family) | NA | group | NA | 1.22e+00 | 2.0e-02 | CCND1,CX3CL1,DAAM1,EGR2,EHD4,ICAM1,NCOA7,OSCAR,PDE3B,PDGFB,RGS3,RNF128,SAMD4A,SERPINE1,TGFB2,TRAF1 | NA |
| HOXD3 | 1.10e-01 | transcription regulator | NA | 1.22e+00 | 0.0e+00 | DSP,ITGA5,JUP,SDC1,SERPINE1,TGM2,THBS1 | NA |
| seocalcitol | NA | chemical drug | NA | 1.22e+00 | 4.0e-02 | CDKN1A,CEACAM1,FOSL1,GADD45A,NOMO1 (includes others),PCNA,SKP2,STAT3,TFAP4,VDR | NA |
| MAPK9 | -2.10e-01 | kinase | NA | 1.22e+00 | 0.0e+00 | BCL2L11,CAV1,CCL5,CDKN1A,CIDEC,DIO2,EIF4E,EPAS1,FOSL1,GADD45A,GADD45B,HMGA1,HMGCS1,IFI16,IL15RA,IL18,IRF9,ISG20,JUN,MARCKSL1,NCL,NR1H3,PARP14,PLA1A,PLAT,RAD23B,SREBF1,TLR3,VDR | 731 (16) |
| estradiol-17beta-benzoate | NA | chemical reagent | NA | 1.21e+00 | 0.0e+00 | ABCA4,ACE,ASIC4,CABP7,CBLN2,CCND1,CCNE1,CDC25A,CHGB,COL2A1,GFRA1,GREB1,GRIN1,INMT,KATNAL1,LAMB3,MAD2L1,MYCN,NECTIN1,NET1,NR4A2,Nup62cl,OXTR,PCSK6,PIM3,PROCR,REC8,RET,SDC1,SV2B,VGF | 308 (7) |
| PI3K (complex) | NA | complex | NA | 1.21e+00 | 0.0e+00 | ABCC4,ATF4,BCL2L11,CCND1,CCNE1,CD55,CD86,CDKN1A,CXCL10,DUSP1,E2F4,FBXO32,FOSL1,FUT7,GJA1,HAS1,HK2,ICAM1,IL33,INHA,JUN,LASP1,LEF1,LEP,MAP2,MAP3K5,MTHFD2,NCL,NFATC1,NQO1,NR4A2,RBL2,SERPINE1,SKIL,SREBF1,TGM2,THBS1,TNFRSF10A,TNFSF10,UGCG | 782 (22) |
| TP53 | 3.60e-01 | transcription regulator | NA | 1.21e+00 | 0.0e+00 | ACE,ACSL3,ACTN4,ADRB3,AHCY,AK1,AKR1B1,ANGPT1,APBB2,AQP3,ARAP2,ASNS,ATAD2,ATF4,ATG10,ATG4C,ATG7,ATL3,ATPAF2,ATXN1,AURKA,AXIN2,BAD,BCAT1,BCL2L11,BCL3,BCL6B,BDKRB2,BHLHE40,BIRC2,BOP1,BRAF,CA9,CARD11,CARS1,CAV1,CAV2,CCL5,CCND1,CCNE1,CCNF,CDC25A,CDC42EP3,CDKN1A,CELSR3,CGREF1,CHEK2,CHMP4C,CKB,CLIC4,COL18A1,COL2A1,CPOX,CRACR2B,CSTB,CSTF1,CTF1,CX3CL1,CXCL10,CXCR3,DCLRE1A,DDB2,DDIT4L,DDR1,DDX39A,DUSP1,DUSP5,E2F4,EDA2R,EGFL6,EGR2,EGR3,EIF4A1,ENO3,EPAS1,ERCC5,ESR1,EZH2,F11R,F2R,FDFT1,FGF13,FGF7,FMO1,FOSL1,FZD7,GADD45A,GADD45B,GAS1,GBP1,GJA1,GLRX,GML,GMNN,GNL3,GOLGA4,GPHN,GPR157,GPR83,HDAC5,HHIP,HK2,HMGA1,HMGCS1,HMMR,HSPA1A/HSPA1B,HSPA5,HSPH1,ICAM1,ID3,IDH1,IER3,IFI16,IFI35,IFI44,IFI44L,IFIH1,IGDCC4,IL12RB1,IL33,INMT,IRAK2,IRF1,IRF7,IRF9,Irs3,ITGA2,ITGA2B,ITGAV,JMJD1C,JUN,KAT2B,KCNH2,KCNJ2,KLF4,LAMA5,LAMC2,LASP1,LGR5,LOX,LRAT,LSS,LTBP1,MAD1L1,MAD2L1,MAP1LC3A,MAP2K3,MAP4K5,MATN4,MCM3,MCM4,ME2,MIS18BP1,MLH1,MPDZ,MPV17L,MRPL34,MSH2,MTHFD2,MX1,MYBL2,MYO10,MYOF,NDRG1,NLRX1,NMU,NOS1,NPEPPS,NR0B2,NR4A3,NUSAP1,P2RY14,P4HA1,PABPC4,PAK1,PARP1,PARP2,PAWR,PCNA,PCNX2,PDE4B,PDGFB,PDK2,PDLIM5,PEX2,PHLDA3,PIGF,PIK3R4,PIK3R5,PLK1,PMEPA1,PML,POLA1,POLD1,POLE2,POLK,PRC1,PRKCB,PROM1,PSTPIP2,PTP4A1,PTPN1,PTPRN,PTPRO,PTPRU,RAD51,RAD54B,RAMP2,RBBP6,RBL2,RBM3,RBM34,RHOF,RLIM,RPS18,RRM2,RRP1B,SCNN1A,SEC61A1,SERPINB2,SERPINE1,SERPINH1,SKP2,SLC16A1,SLC5A8,SLC7A11,SLC7A5,SMC2,SOCS2,SREBF1,STAT1,STAT3,STEAP3,TEX15,TFRC,TGFB2,TGM2,THBD,THBS1,TIMM9,TIMP3,TINAGL1,TLR3,TMEM43,TNC,TNFRSF10A,TNFSF10,Tpm4,TRAF1,TRIM67,TRPV1,TUBA1C,TUBB4B,TXNRD3,UBE2C,UBE2D1,UCP3,ULK2,UPP1,VANGL1,VAPA,VCAN,VCL,VDR,VRK1,VWCE,WNT5B,XPO1,YBX1 | 781 (24) |
| APC | 1.50e-01 | enzyme | NA | 1.21e+00 | 1.0e-02 | ADGRV1,ASCL2,AXIN2,CCND1,CD55,CDKN1A,CHGB,CLDN4,GHRL,HK2,HNF1A,ICAM1,ID3,ITGA2,JUN,KLF4,LGR5,NUMBL,PDK2,PRKCB,TEKT1,THBS1,TIAM1,TIMP3 | NA |
| Foxo | NA | group | NA | 1.21e+00 | 0.0e+00 | BCL2L11,CDKN1A,FBXO32,GADD45A,PAK1,TRIM63 | 534 (11) |
| GABPB1 | 5.00e-01 | transcription regulator | NA | 1.21e+00 | 3.0e-02 | AURKA,OXTR,SKP2,TNC,UCP3 | NA |
| prostaglandin E2 | NA | chemical - endogenous mammalian | NA | 1.21e+00 | 0.0e+00 | Acan,ADAMTS1,ADAMTS4,ANGPT1,ANGPTL4,AQP3,BCL2L11,Casp12,CCL5,CCND1,CD55,CD83,CD86,CDKN1A,CLEC7A,CXCL10,CXCR3,DGAT1,DLL1,DUSP1,EGR2,F2R,FOSL1,FSCN1,GBP5,GJA1,H2-T24,HEG1,ICAM1,IER3,IL12RB1,IL15RA,IL18,IL1R2,IRF1,ITGA5,JUN,KLF4,LIPG,LOX,MMP19,NEDD9,NFIL3,NR1H3,NR4A2,NT5E,OSBPL3,PDE4A,PDE4B,PENK,PROM1,SAP30,SCARB1,SLC5A1,SOCS2,TFRC,TGFBR3,THBD,THBS1,TSC22D1,UCP2,VEGFC,XRCC6 | 787 (17) |
| fluticasone propionate | NA | chemical drug | NA | 1.20e+00 | 0.0e+00 | ANGPTL4,C8orf44-SGK3/SGK3,CCL5,CD83,CD86,CXCL10,CYP27B1,FSCN1,GADD45B,GAL,GBP5,IL1R2,MERTK,MMP19,MX1,OAS2,OLFML2B,OLR1,SERPINB2,SERPINE1,SLC2A5,STAT1,TGM2,THBS1,TIMP3,TSC22D1 | 700 (17) |
| trans-cinnamaldehyde | NA | chemical drug | NA | 1.20e+00 | 1.0e-02 | CDKN1A,FMO5,MAD2L1,POR,SERPINE1,TH,TXNRD1 | 394 (7) |
| Nr1h | NA | group | NA | 1.19e+00 | 0.0e+00 | ACE,ACSL3,AGT,APOC2,AQP3,BCL3,CAV1,CCL5,CXCL10,ELOVL4,ELOVL7,F2R,GPAM,H6PD,IFIH1,MARCKSL1,MERTK,NLRP3,Oas1b,PML,REN,SCARB1,SP110,SREBF1,THBS1,TIMP3 | 497 (20) |
| PDX1 | NA | transcription regulator | NA | 1.19e+00 | 0.0e+00 | ABCC8,ACTG1,AKR1B1,ASNS,ATF4,ATP2A2,CCND1,CHGB,CKB,CX3CL1,DUSP5,GCH1,GLP1R,HSPA5,ID3,IDH1,IER3,JUN,LRRC49,LTA4H,MAP2,MPHOSPH10,Mt1,NPTX2,NQO1,PCNA,PDE4B,PDIA4,PTP4A1,S100G,TGFBR3,TSPAN8 | 503 (17) |
| everolimus | NA | chemical drug | NA | 1.19e+00 | 1.0e-02 | ABCB10,ASCL2,AXIN2,CAV1,CCND1,CCNE1,CDKN1A,FSCN1,LGR5,XPA | 658 (20) |
| cerivastatin | NA | chemical drug | NA | 1.18e+00 | 1.0e-02 | CDKN1A,ETV6,GCH1,HMGCS1,ICAM1,JUN,MYBL2,NET1,NFYA,PLAT,SERPINE1,TGFBR3,THBD | NA |
| decitabine | NA | chemical drug | NA | 1.18e+00 | 0.0e+00 | ABCB10,ABCC4,ABCC8,ADAMTS1,ALS2,ANGPTL4,ATF1,BAIAP2,BCAT1,BCL2L11,BIN1,BTG3,CA9,CAB39L,CASZ1,CAV1,CCL5,CCND1,CD86,CDKN1A,CDKN1C,CEACAM1,CFTR,CGREF1,CSE1L,CXCL10,CXCR3,DHRS3,DUSP1,EDA2R,EFNB2,EGFL6,EGR3,EHD1,EIF4E,ELOVL4,EPHA5,EPHB6,ESR1,FBN2,FLRT3,GADD45B,GFRA1,GLRB,GLRX,HK2,HLA-G,HMMR,HNRNPD,HSPA1A/HSPA1B,HSPA5,HSPB8,ICAM1,IFI16,IFI35,ING1,IRF7,ITGA2,ITGAV,ITGAX,JUP,KLF4,L1CAM,LEF1,LOX,LTBP1,MAP2,MICALL2,mir-154,MLH1,MSH2,MSI1,MX1,NDRG1,NECTIN1,NFATC1,NPTX2,NQO1,NR1H3,NR4A2,OPRD1,PAK1,PAWR,PCNA,PDGFB,PDLIM2,PDLIM5,PHF19,PKP2,PLK1,PTBP2,RAD9A,RASSF1,RASSF3,RET,RIOX2,RPL9,RTP4,SATB1,SCARB1,SERPINH1,SFTPB,SFTPC,SLC30A1,SLC38A1,SLC5A8,SMARCA2,SOCS1,SOX12,STAT1,STAT3,STC2,STEAP2,TFAP4,TFRC,TGFB2,TGM2,THBD,THBS1,TIAM1,TIMP3,TNC,TNFRSF10A,TNFSF10,TSC22D1,ULK2,USP7,VCAN,VCL,WNT5A,WRN,XPO1 | 808 (20) |
| KLF2 | -1.50e-01 | transcription regulator | NA | 1.18e+00 | 0.0e+00 | ACE,ACKR3,APLNR,AQP5,BCL3,CAV1,CCL5,CD55,CD86,CDKN1A,CXCR3,DLL1,ELN,EPAS1,FGR,GADD45A,ID3,MAP3K5,NDRG1,NQO1,PLPP3,RGS3,Serpinb6b,SERPINE1,SLCO2A1,SREBF1,STAT1,STAT3,TFRC,TGFB2,THBD,THBS1,TNFSF10 | 374 (13) |
| SORL1 | NA | transporter | NA | 1.18e+00 | 0.0e+00 | AGT,ANGPT1,CAV1,COL18A1,COL2A1,EPHA5,FGF7,GAL,ICAM1,ITGA11,ITGA2,ITGA5,ITGAV,LRP2,PACS1,PDGFC,PLXND1,RTN4R,SCARB1,SEMA3E,SSTR1,TGFBR3,TGM2,TNC,TNFRSF10A,VEGFC,WNT5A | 658 (15) |
| PBX1 | 7.20e-01 | transcription regulator | NA | 1.18e+00 | 1.0e-02 | AMD1,CDKN1A,ETV1,FABP7,Meis1,NFIL3,REN,STAT3 | NA |
| semaxinib | NA | chemical drug | NA | 1.18e+00 | 1.0e-02 | ACKR3,ARHGEF10,CARD11,CCNE1,CLEC10A,CSF2RB,CXCL10,CXCL11,EGR2,FGF12,GREM1,IL1R2,MYOF,NLRP3,NR4A2,PARP1,PCNA,SERPINE1,TFEB,THBS1,TLR5 | 785 (23) |
| ACVR1C | -6.50e-01 | kinase | NA | 1.17e+00 | 5.0e-02 | ADRB3,CCND1,CDKN1A,KLF4,SERPINE1 | NA |
| MTOR | -3.60e-01 | kinase | NA | 1.17e+00 | 1.0e-02 | ADPGK,AKR1B1,ATG7,ATP2A2,BCL2L11,CAB39L,CCND1,CCNE1,CD86,CDKN1A,DUSP1,EPAS1,EPRS1,FBXO32,GLG1,GPHN,HK2,HNF1A,HSPH1,IFI16,INHA,IRF1,JAK2,LEP,MAP2,MEFV,PCNA,PDE4A,PDK2,PLD2,PTBP1,RPS18,SKP2,SMPD1,SREBF1,STAT1,STAT3,TK1,TLR5,TMCC1,TNFRSF10A,TNFSF10,TRADD,TRIM63,UBE2C,USP40 | 759 (21) |
| 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene | NA | chemical toxicant | NA | 1.17e+00 | 1.0e-02 | ABCC4,CCND1,CDKN1A,CYP39A1,DIO2,GADD45B,ICAM1,MAD2L1,MAFF,Mt1,NEDD9,PDE3B,PNPLA2,Slco1a4,SREBF1,Sult1d1,UCP2,UCP3 | NA |
| DGAT1 | 2.10e+00 | enzyme | NA | 1.17e+00 | 4.0e-02 | DGAT1,HSPA5,LEP,PNPLA2 | NA |
| 24-hydroxycholesterol | NA | chemical - endogenous mammalian | NA | 1.16e+00 | 1.0e-02 | ACE,AGT,HSPA5,REN,SREBF1 | 601 (13) |
| CD44 | 0.00e+00 | other | NA | 1.16e+00 | 1.0e-02 | ACKR3,ACTR6,ADPGK,ANXA11,BIRC2,CCL5,CCND1,CDKN1A,CIDEC,CLEC7A,COL18A1,CX3CL1,CXCR3,FOXK1,GADD45A,HMMR,IL1R2,ITGA5,ITGAV,ITGAX,JUN,KLF4,LIMS2,LTBP1,LY6D,NR1D1,PLPP3,PMEPA1,STAT2,THBS1,TIAM1,WNT5A | 824 (21) |
| PRKCD | 7.20e-01 | kinase | NA | 1.16e+00 | 0.0e+00 | ALOXE3,ARHGAP32,BIRC2,CCL5,CCND1,CCNE1,CDKN1A,CX3CL1,CXCL10,EPOR,ERCC6L,FOSL1,FZD1,GEM,GPRC5A,ICAM1,JUN,LAMB3,LIPG,MAST4,MSI1,NOCT,NR0B2,PLSCR1,PROM1,SERPINB2,SERPINE1,SOCS1,STAT3,TLR2,TRAF1,TUBB2A,UGCG | 712 (17) |
| DYRK1A | 5.30e-01 | kinase | NA | 1.15e+00 | 0.0e+00 | CCND1,CDKN1A,MCM3,MCM4,MYBL2,SERPINE1,UBE2C | 667 (24) |
| IL13 | NA | cytokine | NA | 1.15e+00 | 2.0e-02 | ACKR3,ADAMTS4,ADORA1,AMPD2,BCL3,BIRC2,BLVRA,BPIFC,BZW2,CCL24,CCL5,Ccl6,CD86,CISH,CLEC10A,CLEC7A,COL18A1,CX3CL1,CXCL10,DMXL2,EGR2,EPAS1,FADS1,FLOT1,FZR1,GRIN1,ICAM1,IL18,IL1R2,ITGAX,JUN,KCNH2,KLF4,LTA4H,LTBP1,MERTK,NFATC1,PDGFC,PDLIM2,PLCXD1,PLXNC1,SERPINE1,SFTPC,SLC26A6,SLC7A7,SOCS1,SPDEF,SPINT1,TFRC,TGM2,THBS1,TPSAB1/TPSB2,TRPV1,WNT5A | NA |
| acetaminophen | NA | chemical drug | NA | 1.14e+00 | 1.0e-02 | ABCC4,ACTG1,AKR1B1,BLVRA,CCND1,CDKN1A,CXCL10,CXCR3,FTL,GADD45A,GLRX,HMGCS1,HSPA5,ICAM1,IDH1,IL18,JUN,LIPC,LIPH,mir-154,Mt1,NQO1,NR1H4,PCNA,PNPLA2,PRKCB,PTPN1,Scd2,SLC7A11,TLR3,TXNRD1 | NA |
| puromycin aminonucleoside | NA | chemical reagent | NA | 1.14e+00 | 0.0e+00 | ACTG1,ADAMTS1,ASNS,BCAR1,Bex2/LOC100912195,CDCP1,CLDN4,CLIC5,Ctla2a,FXYD5,GTPBP4,HSPA5,IER3,LAMC2,MCM3,PLA1A,RBM3,SCARB1,TSPAN8,UCP3,UPP1 | NA |
| INSIG1 | 5.10e-01 | other | NA | 1.14e+00 | 0.0e+00 | ATF4,CCL5,CLEC4D,CLEC7A,CXCL10,Cxcl3,FADS1,FDFT1,GPAM,HMGCS1,HSPA5,JUN,LIPG,LSS,OLR1,PLA2G4F,SCARB1,Scd2,SREBF1,STEAP2,UCP2 | 448 (11) |
| SPRY1 | NA | other | NA | 1.13e+00 | 0.0e+00 | AXIN2,ETV1,FABP7,FGF7,FGF9,LOX,LOXL3 | NA |
| TFPI2 | -1.10e-01 | other | NA | 1.13e+00 | 1.0e-02 | ADAMTS4,CCND1,CXCL10,DIO2,EFNB2,GADD45B,HSPA2 | 264 (7) |
| PIK3C3 | -1.40e-01 | kinase | NA | 1.13e+00 | 1.0e-02 | DIO2,LEP,PNPLA2,PRDM16,SCARB1,SREBF1,VPS36 | NA |
| HR | 1.80e-01 | transcription regulator | NA | 1.13e+00 | 1.0e-02 | AMD1,CSNK2A2,FGF13,GJA1,IL1R2,KDSR,LEF1,NACC2,VDR | NA |
| IMMT | -3.00e-02 | other | NA | 1.13e+00 | 4.0e-02 | CD55,CXCL10,MX1,OAS2,SERPINB2,SERPINE1,VEGFC | NA |
| noscapine | NA | chemical drug | NA | 1.13e+00 | 3.0e-02 | BIRC2,CCND1,ICAM1,TRAF1 | NA |
| CLOCK | 3.40e-01 | transcription regulator | NA | 1.13e+00 | 0.0e+00 | ABCB10,ADPGK,ANGPTL4,ARHGEF10,BHLHE40,CCND1,CD86,CHTF8,EEF2K,F2R,FABP7,FAM107A,GADD45A,GADD45B,GJA1,Gm12854/S100a11,GNPTAB,HES6,HSPH1,ICAM1,KANK2,MAP2K3,MID1IP1,NFIL3,NOCT,NR0B2,NR1D1,POR,PPIF,PRELID3B,RIOX2,RSPH3,SCN4B,SMARCD2,SRD5A1,ST3GAL5,TBRG4,THBD,THBS1,TMEM222,TNFRSF21,UBE3C | NA |
| FN1 | -1.70e-01 | enzyme | NA | 1.12e+00 | 4.0e-02 | ACE,ACTN4,AHCY,BCAT1,CCL5,CCND1,CCNE1,CD83,CDKN1A,CLIC4,EIF5A,ITGA5,ITGAV,KCNH2,PCNA,PDGFB,PTBP1,RDX,SDC1,SERPINE1,SKP2,TGM2,THBS1,TLR2,TNIP1,VCL | NA |
| SMAD4 | -1.00e-02 | transcription regulator | NA | 1.12e+00 | 0.0e+00 | Acan,ANGPT1,ANGPTL4,AURKA,BMP7,CCL24,CCND1,CCNE1,CDC42EP3,CDKN1A,COL2A1,ERCC5,ETV6,FOSL1,FSCN1,FUT7,FZR1,GADD45A,GADD45B,GJA1,GNRHR,GUCY2F,ICAM1,IER3,IL18,IL20,LEF1,MAD2L1,MYCN,PDGFB,POR,RASSF1,SERPINE1,SFTPB,SKIL,SLC23A2,TBX6,TGFB2,THBS1,TIMP3,TNC,TNFRSF10A,UNC119 | 720 (24) |
| IFI16 | -7.20e-01 | transcription regulator | NA | 1.12e+00 | 0.0e+00 | BAD,CCL5,CCND1,CDC25A,CDKN1A,CXCL10,ESR1,GADD45A,ICAM1,IFI16,MTHFD2,PCNA,SSTR1,STAT2,UCP3 | 716 (21) |
| TAB1 | 1.80e-01 | enzyme | NA | 1.12e+00 | 0.0e+00 | CCL5,CDKN1A,CXCL10,GBP1,GCH1,IFIH1,IRF7,JUN,SERPINE1,TNFSF10 | 647 (20) |
| promegestone | NA | chemical drug | NA | 1.11e+00 | 2.0e-02 | ABCC8,CCND1,CCNE1,CDKN1A,DUSP5,GAL,IER3,INHBB,LAMC2,NET1,S100G,STAT1,STAT3,TK1 | NA |
| ATF6 | 3.00e-01 | transcription regulator | NA | 1.11e+00 | 5.0e-02 | ATP2A2,AURKA,HMMR,HSPA5,NR0B2,PDIA4,PLAT,TXNDC5,UBE2C,UNC13B | NA |
| ZBTB17 | 4.10e-01 | transcription regulator | NA | 1.11e+00 | 0.0e+00 | BHLHE40,BTG3,CCND1,CDKN1A,CDKN1C,DDB2,ECT2,EDA2R,HMMR,IER3,JUN,KIF18B,NOCT,NUSAP1,OSMR,PLK1,PRC1,SOCS1,TMEM11,UBE2C | 618 (21) |
| fluvastatin | NA | chemical drug | NA | 1.11e+00 | 2.0e-02 | CCND1,CCNE1,CDKN1A,GCH1,PLAT,SERPINE1,THBD,TNFSF10 | NA |
| withaferin A | NA | chemical reagent | NA | 1.11e+00 | 3.0e-02 | BCL2L11,CDKN1A,SERPINE1,SKP2 | NA |
| azetidyl-2-carboxylic acid | NA | chemical reagent | NA | 1.10e+00 | 1.0e-02 | ASNS,ATP2A2,HSPA1A/HSPA1B,HSPA5 | NA |
| 5-hydroxytryptamine | NA | chemical - endogenous mammalian | NA | 1.09e+00 | 4.0e-02 | ANGPT1,ASIC1,BAD,BIN1,F2R,GHRL,ICAM1,ITGA2B,LIPC,PLIN3,SERPINB2,SERPINE1,SLC6A4,THBS1,TRPV1,UCP2,UCP3 | NA |
| UCP1 | 3.40e-01 | transporter | NA | 1.09e+00 | 0.0e+00 | AMD1,ASNS,ATF4,ATG7,BZW2,CDKN2AIPNL,CLCN3,CPNE2,CXCL10,FBXO32,FGF7,GADD45A,HSD17B7,LEP,MAP1LC3A,MSS51,MTHFD1,MTHFD1L,MTHFD2,PSD3,SERPINE1,SHMT1,SLC3A2,STAP2,STBD1,TBC1D31,TLR3,UCP2,UCP3 | 312 (7) |
| STAT5a/b | NA | group | NA | 1.08e+00 | 1.0e-02 | BCL2L11,CCND1,CDC25A,CDKN1A,CISH,DUSP1,ERFE,F2R,GNAZ,IGFALS,IRF1,ITGA2B,NETO2,NIFK,PDE4B,PDGFB,PROX1,RAD51,SOCS1,TLR2 | 625 (18) |
| TLR2 | -1.06e+00 | transmembrane receptor | NA | 1.07e+00 | 0.0e+00 | CCL5,CD86,CDKN1A,CISH,CXCL10,CYP27B1,DUSP1,FBXO32,GADD45A,GJA1,GRIN1,ICAM1,IL15RA,IL18,IL33,IRAK4,IRF1,ITGA2B,LEP,MX1,NR1H4,OLR1,OXTR,PTGFR,SLC7A11,SOCS1,TLR2,TNFSF10,TRIM63,VDR | 774 (17) |
| LAMA4 | 1.40e-01 | enzyme | NA | 1.07e+00 | 4.0e-02 | ANGPT1,ANPEP,CAV1,CAV2,CCND1,CTF1,GSTT2/GSTT2B,IDH1,IL18,ITGAV,LAMA5,PDGFC,THBS1,VEGFC | NA |
| P1,P4-Di(adenosine-5’) tetraphosphate | NA | chemical - endogenous mammalian | NA | 1.07e+00 | 0.0e+00 | NR0B2,TGFB2,THBS1,TPSAB1/TPSB2 | NA |
| SW016789 | NA | chemical reagent | NA | 1.07e+00 | 0.0e+00 | ATF4,DUSP1,HSPA5,NR4A3 | 319 (7) |
| PTK2B | 1.00e-01 | kinase | NA | 1.07e+00 | 2.0e-02 | BCAR1,JUN,NEDD9,SOCS1,VCL | NA |
| H-151 | NA | chemical reagent | NA | 1.07e+00 | 2.0e-02 | CCL5,CXCL10,IFI44,IRF7 | NA |
| miR-101-3p (and other miRNAs w/seed ACAGUAC) | NA | mature microRNA | NA | 1.07e+00 | 2.0e-02 | ATM,EZH2,MYCN,PRKDC | NA |
| icatibant | NA | biologic drug | NA | 1.07e+00 | 2.0e-02 | BDKRB2,CHRM1,ICAM1,STAT3 | NA |
| PPP2CA | 2.90e-01 | phosphatase | NA | 1.07e+00 | 2.0e-02 | BCL2L11,CCND1,CDKN1A,CXCL10,IRF1,IRF7,NT5E,Oas1b,SOCS1,STAT1,UPP1 | NA |
| WWTR1 | 1.40e-01 | transcription regulator | NA | 1.06e+00 | 1.0e-02 | ADGRG5,AMN1,ANGPTL4,CCND1,CDKN1A,ESR1,GJA1,ICAM1,IFIH1,IRF7,IRF9,LAMA5,MX1,NF2,OXSM,PLIN4,RRM2,SERPINE1,STAT1,TK1,TNFRSF10A | NA |
| JUND | 9.00e-02 | transcription regulator | NA | 1.06e+00 | 2.0e-02 | AGT,BCL3,CCL5,CCND1,CXCL10,FOSL1,GNRHR,PENK,SDC1,SERPINB2,SOCS1,TH,TK1 | NA |
| arsenite | NA | chemical toxicant | NA | 1.06e+00 | 0.0e+00 | ATF4,CAV1,CCND1,CDKN1A,DUSP1,FZD1,GADD45A,HSPA1A/HSPA1B,IER3,INHBB,IRF1,JUN,MAFF,NQO1,PRKDC,SERPINE1,TGFB2,THBS1,TXNRD1 | 693 (18) |
| FOXO1 | 1.30e-01 | transcription regulator | NA | 1.06e+00 | 0.0e+00 | Acan,AGT,ANGPT1,ANGPTL4,ATF4,BCL2L11,CAV1,CCND1,CCNF,CDC42EP3,CDKN1A,CDKN1C,CDKN2AIPNL,CNR1,COL2A1,COMP,CXCL10,DIO2,EGR2,ELOVL5,ELOVL7,FBXO32,GADD45A,GADD45B,GPAM,HDAC8,HSPA5,ICAM1,IER3,IL10RB,IL18,ITGAV,JUN,KLF4,LEP,LRAT,MRPL34,MRPS12,MYCN,NFATC1,NR1H4,NUSAP1,PAK1,PLSCR1,PNPLA2,PRC1,PRCP,PRKCD,RBL2,RPIA,SCARB1,SERPINB2,SERPINE1,SLC25A15,Slc25a2,SREBF1,STAT2,THBS1,TNFSF10,TRADD,TRAF1,TRIM63 | 782 (25) |
| HDAC3 | 1.70e-01 | transcription regulator | NA | 1.06e+00 | 4.0e-02 | Acan,CCND1,CD55,CDKN1A,CXCL10,ELOVL5,GPAM,HK2,ICAM1,JUP,NFATC1,SERPINE1,SMARCA2,TBX4,USP18 | NA |
| fludarabine | NA | chemical drug | NA | 1.05e+00 | 1.0e-02 | CCND1,CCNE1,CDKN1A,DDB2,IRF1,LEP,PCNA,STAT1,TNFRSF10A | 594 (23) |
| PG3-Oc | NA | chemical reagent | NA | 1.05e+00 | 3.0e-02 | ATF4,CDKN1A,DDB2,HHAT,NDRG1,TNFRSF10A | NA |
| IL2 | NA | cytokine | NA | 1.04e+00 | 0.0e+00 | ACSL3,ARHGAP32,ARHGEF6,ASNS,ATM,AURKA,BCAT1,BHLHE40,CACNG3,CCL5,CCND1,CCNE1,CCNF,CD200R1,CD83,CD86,CDC25A,CDKN1A,CDKN1C,CEACAM1,CISH,CSF2RB,CXCL10,CXCR3,DARS2,DGAT1,DPYSL5,DUSP1,DUSP5,E2F4,ELOVL5,EPAS1,FGF13,FGF7,FGF9,GADD45B,GEM,GNL3,GPR83,HDAC1,HEATR9,HK2,HMGCS1,HOPX,HSPA1A/HSPA1B,HSPA5,ICAM1,IDH1,IER3,IFI16,IL12RB1,IL18,IL1R2,IRF1,ISG20,ITGA2,JAK2,JUN,L1CAM,LAMA5,LGALS12,LILRB4,LSR,MAD2L1,MAPKAPK2,MTHFD2,MX1,NDRG1,NET1,NETO2,NIFK,NPTX2,NR4A3,NT5E,OSBPL3,PCNA,PDE3B,PDE4A,PDE4B,PDGFC,PENK,PINX1,PLK1,POLE2,POLR1C,PPAT,PPP2R2B,PRKX,RFFL,RNF128,RRM2,SATB1,Scd2,SEMA4A,SERPINE1,SHMT1,SLC30A1,SLC3A2,SLC7A5,SOCS1,SOCS2,SORD,STAT3,STC2,TFDP2,TFEB,TFRC,TGFBR3,TLR2,TNFRSF10A,TNFRSF21,TNFSF10,TRAF1,UPP1,ZDHHC23 | 715 (19) |
| fulvestrant | NA | chemical drug | NA | 1.04e+00 | 0.0e+00 | ASCC3,ASNS,ATF4,AURKA,BLM,CAV1,CAV2,CCL5,CCND1,CCNE1,CDC25A,CDKN1A,CHTF18,CXCL10,CXCL11,Cxcl3,EGR3,EPOR,ESR1,F2R,FGF9,GADD45A,GAL,GJA1,GREB1,HSD17B7,ICAM1,IER3,INHBB,IRF1,JUN,MCM3,MTHFD1,NOS1,NQO1,PCNA,RBL2,RNF4,S100G,SKP2,SLC7A5,SLC9A3,SMPD1,STAT3,TFRC,TGFB2,TGFBR3,TK1,UBE2C | 772 (22) |
| NFE2L2 | -2.00e-01 | transcription regulator | NA | 1.03e+00 | 0.0e+00 | ABCC4,ACE,ACTG1,ADAMTS1,AGT,APPBP2,ATF4,ATG7,B4GALNT1,CA11,CCL5,CD86,CDKN1A,CHGB,CHORDC1,CXCL10,EIF3C,ELN,EPAS1,ETV6,FGF13,FMO1,FTL,Fus,GSTT2/GSTT2B,HMBS,HMGCS1,HNF1A,HTATIP2,ICAM1,IDE,IDH1,IFIH1,IL19,IL1R2,IL20,INMT,L1CAM,MAFF,MAP1LC3A,MED31,Mt1,NDST1,NOCT,NQO1,NR0B2,OSCAR,PDIA4,PHKA1,PKIA,PRKCB,PTPN1,PTPRO,RAMP2,RRS1,SCARB1,SEC61A1,SERPINE1,SLC38A1,SLC7A11,SREBF1,SYT5,TGFB2,TIMP3,TK1,TOLLIP,TXNRD1,UBA2 | 595 (15) |
| TRPV4 | -1.20e-01 | ion channel | NA | 1.03e+00 | 2.0e-02 | AQP5,CCL5,COL2A1,CXCL10,DUSP1,THBS1,TLR2 | NA |
| etanercept | NA | biologic drug | NA | 1.03e+00 | 5.0e-02 | BMP7,CD83,CXCL10,ICAM1,NFATC1,Slco1a4,STAT1 | NA |
| SOX2 | -2.60e-01 | transcription regulator | NA | 1.02e+00 | 0.0e+00 | ACKR3,ADAMTS4,AFAP1L2,ANGPT1,ARHGEF10,ASCL2,ATG10,AXIN2,BHLHE40,BMPER,CCL5,CCND1,CDKN1A,CHADL,COL11A2,CXCL10,DLL1,DSP,DUSP1,DUSP5,EXT2,FABP7,FARP1,GADD45B,GBP4,GJA1,GJC2,GLTP,GREB1,HHAT,HOPX,ID3,IRF6,JARID2,JUN,KIF16B,KLF4,LEF1,LIMS2,LLGL2,LRRC4,Meis1,MYCN,NF2,NKX6-2,NSFL1C,Oasl2,PRKCD,PROM1,RNF43,SERPINE1,SLC7A11,SNX22,SOX8,TBX6,TEAD3,TEC,TFAP4,TGFB2,TGM1,TIMP3,TMEM163,TXNRD1,USP18,VCAN,VEGFC,WNT5A | 671 (18) |
| Creb | NA | group | NA | 1.02e+00 | 0.0e+00 | ABL2,ANKRA2,ATG7,ATP2A2,CCND1,CDKN1A,CIDEC,CXCL10,DDX42,DUSP1,EGR3,FHDC1,FOSL1,FSCN1,GJA1,GPR50,GTF2F2,HLA-G,HSPB8,IER3,IFI16,IL33,INHA,JUN,KCNA5,LASP1,Ldha/RGD1562690,LEP,MCM3,MED31,NCOA2,NEDD9,NPHS2,NR4A2,NR4A3,OSBPL3,PCNA,PDE3B,PDE4B,PENK,PLAT,PLIN3,POLA1,PPRC1,RET,RRM2,SERPINB2,SKIL,SLC7A11,Slco1a4,SOX12,TFEB,TGFB2,TH,TRIM6-TRIM34,USP8 | 763 (27) |
| S100A8 | -1.40e-01 | other | NA | 1.01e+00 | 0.0e+00 | ADAMTS1,ADAMTS4,BCL3,BHLHE40,BIRC2,CCND1,CPM,CSF2RB,CSTF1,CXCL10,ELN,FOSL1,GPRC5A,ICAM1,IL33,LTBP1,NR1H4,NR4A3,NRG1,OLR1,PDGFC,PTPRO,RAB20,SDCBP2,SLC26A1,USP18,VCAN,VGF | 786 (20) |
| E. coli B5 lipopolysaccharide | NA | chemical - endogenous non-mammalian | NA | 1.01e+00 | 0.0e+00 | ACKR3,ADAMTS1,BCL3,BHLHE40,BIRC2,CCL24,CCL5,Ccl6,CCND1,CD83,CD86,CDKN1A,CX3CL1,CXCL10,Cxcl3,CXCR3,DUSP1,FMO1,ICAM1,Igtp,IL15RA,IL18,IL1R2,INHBB,IRF1,ISG20,PAH,PDE4B,PRDM16,RDX,SDC1,SEPHS2,SERPINE1,SOCS2,STAT3,TGFB2,TGFBR3,TGM2,THBS1,TLR2,TLR3,TOLLIP,UBE2I | 710 (18) |
| IL1B | -1.60e-01 | cytokine | NA | 1.01e+00 | 0.0e+00 | Acan,ACE,ADAMTS1,ADAMTS4,AGER,AKR1B1,ANGPT1,ANGPTL4,APOC2,ATF4,ATG7,ATP2A2,BAMBI,BCL3,BIRC2,BMP7,C19orf25,CABP1,CAV2,CCL24,CCL5,CCND1,CCNF,CCRL2,CD55,CD83,CD86,CDKN1A,CFTR,CISH,COL2A1,CRISPLD2,CSF2RB,CX3CL1,CXCL10,CXCL11,CYP27B1,DLL1,DUSP1,DUSP5,EHD1,EIF4E,ELN,EPAS1,EPSTI1,ESR1,ETV1,FGF7,FOSL1,FUT7,FZD1,GADD45A,GADD45B,GBP1,GBP4,GBP5,GCH1,GCHFR,GEM,GFRA1,GJA1,GNA15,HAS1,HDAC1,HELZ2,HK2,HMGA1,HSPA1A/HSPA1B,HSPA5,HSPB8,ICAM1,ID3,IDH1,IER3,IFI16,Ifi47,IGFALS,IL15RA,IL18,IL19,IL1R2,IL20,IL33,IRAK2,IRF1,IRF7,ISG20,ITGA5,ITGAV,JUN,JUP,KCNH2,KCNJ1,KLF4,LAMB3,LAMC2,LCP1,Ldha/RGD1562690,LEF1,LEP,LOX,MAPKAPK2,MARCKSL1,MEFV,METRNL,Mt1,MX1,NCOA2,NFIL3,NFKBIB,NOCT,NOP56,NOS1,NQO1,NR0B2,NR1D1,NR1H3,NR1H4,NR4A2,NR4A3,OAS2,OLR1,OSGIN2,OSMR,OXTR,PAK1,PCNA,PCSK6,PDE4B,PDGFB,PDGFC,PDGFD,PELI3,PENK,PIM3,PLAT,PLSCR1,PRKCD,PTGFR,PTP4A1,PTPRN,REN,RORA,RRP1B,RRS1,SAA2-SAA4,SCARB1,SCLY,SCNN1A,SCNN1B,SCNN1G,SCUBE2,SCX,SDC1,SEC61A1,SERPINB2,SERPINE1,SERPINH1,SFTPC,SLC14A1,SLC6A4,SLC7A11,SLC9A3,Slco1a4,SOCS1,SOCS2,SPAG1,SREBF1,STAT1,STAT3,TFRC,TGFBR3,TGM1,TGM2,THBD,THBS1,TIMP3,TK1,TLE6,TLR2,TLR3,TNFRSF10A,TNFSF10,TPT1,TRAF1,TSR1,UCP3,UGCG,USP18,VCAN,VDR,VEGFC,WNT5A | 799 (19) |
| 25-hydroxycholesterol | NA | chemical reagent | NA | 1.01e+00 | 0.0e+00 | ACAT2,ASNS,ATF4,CCND1,CHAC1,FDFT1,FOSL1,HMGCS1,HSPA5,JUN,MAFF,NR4A2,NR4A3,SCARB1,SREBF1 | 623 (20) |
| GPS2 | 2.10e-01 | transcription regulator | NA | 1.00e+00 | 0.0e+00 | BIN1,CCND1,CDKN1A,CXCL10,DHRS3,FZD1,HIVEP2,IDH1,MBNL1,RAB20,SOCS1,TRERF1,ZNF703 | 631 (20) |
| NFAT5 | -3.30e-01 | transcription regulator | NA | 1.00e+00 | 0.0e+00 | Acan,AKR1B1,AQP3,ATP2A2,C1QTNF1,CHEK2,CXCL10,HSPA2,IFI16,IRF1,Irgm1,NRG1,Oas1b,PLAT,POLA1,PRIM2,PRSS35,PTGFRN,RPA1,RRM2,SCNN1A,SCNN1B,SCNN1G,SEMA4C,SLFN13,STAT1,TLR2,TNC,TNFRSF21,TNFSF10,TRAF1,VCL | 566 (17) |
| mycophenolic acid | NA | chemical drug | NA | 1.00e+00 | 0.0e+00 | ANPEP,CD55,CDKN1A,DUSP1,DUSP14,GBP1,GNL3,HNRNPD,HSPA5,ID3,OLR1,PCNA,PDLIM5,SAMD4A,SERPINB2,SERPINE1,SLC30A1,UGCG | 686 (24) |
| ADAM17 | -2.90e-01 | peptidase | NA | 1.00e+00 | 0.0e+00 | ACTG1,AXIN2,CCND1,CEACAM1,CLDN4,DNAJA1,EFNB2,Fus,Gm12854/S100a11,HMGA1,HSPH1,IRF1,LASP1,MAP1LC3A,MICOS10-NBL1/NBL1,MYCN,NFATC1,NRG1,PLAT,PLIN3,SCARB1,TBX4,VPS16,WNT5A | 796 (21) |
| PIK3CA | -2.00e-01 | kinase | NA | 1.00e+00 | 0.0e+00 | ADAMTS1,AFMID,ATOH8,BAD,CA9,CCND1,CSE1L,EZH2,GALNT3,IL19,IL33,JUN,LEF1,LLGL2,LOX,NUAK2,PALM,PDGFB,PROCR,SERPINE1,SREBF1,TGM1,THBD,TK1,TNFSF10 | 696 (21) |
| SCRIB | -2.60e-01 | other | NA | 1.00e+00 | 1.0e-02 | ASCL2,CXCL10,EPOR,LGR5 | NA |
| quinidine | NA | chemical drug | NA | 1.00e+00 | 1.0e-02 | CCND1,CDKN1A,HDAC1,KCNJ2 | 474 (12) |
| cortistatin A | NA | chemical reagent | NA | 1.00e+00 | 1.0e-02 | BHLHE40,ETV6,IRF1,JARID2 | NA |
| tridecanoic acid | NA | chemical - endogenous mammalian | NA | 1.00e+00 | 1.0e-02 | CDKN1C,DUSP5,KLF4,TNC | NA |
| soloxolone methyl | NA | chemical reagent | NA | 1.00e+00 | 1.0e-02 | ELN,IFI44,RTP4,SERPINE1 | NA |
| sphingomyelin | NA | chemical - endogenous mammalian | NA | 1.00e+00 | 1.0e-02 | ELOVL5,ICAM1,NR1H3,SREBF1 | NA |
| ARV1 | 2.30e-01 | transporter | NA | 1.00e+00 | 1.0e-02 | LEP,NR0B2,NR1H4,SREBF1 | NA |
| orlistat | NA | chemical drug | NA | 1.00e+00 | 1.0e-02 | ATF4,HSPA5,ICAM1,SKP2 | NA |
| trypsin | NA | group | NA | 1.00e+00 | 2.0e-02 | CDKN1A,ELN,ICAM1,PCNA | NA |
| YTHDF2 | 4.20e-01 | other | NA | 1.00e+00 | 2.0e-02 | HIVEP2,KLF4,NR1H3,PDGFC | NA |
| RSPO1 | 1.50e-01 | other | NA | 1.00e+00 | 2.0e-02 | ASCL2,AXIN2,LGR5,RNF43 | NA |
| 2,3,4,7,8-pentachlorodibenzofuran | NA | chemical toxicant | NA | 1.00e+00 | 3.0e-02 | ESR1,FGF9,GADD45A,HSPA1A/HSPA1B,HSPA2,IDH1,NQO1,NR0B2,PTGFR | NA |
| CRTC3 | -1.30e-01 | other | NA | 1.00e+00 | 3.0e-02 | LEP,NR4A3,PDE4B,PDE4D | NA |
| MAFF | 1.77e+00 | transcription regulator | NA | 1.00e+00 | 3.0e-02 | ABCC4,NQO1,STAT3,TXNRD1 | NA |
| ADRB3 | -2.58e+00 | G-protein coupled receptor | NA | 1.00e+00 | 3.0e-02 | DIO2,JUN,LEP,UCP2,UCP3 | NA |
| DIRAS3 | NA | enzyme | NA | 1.00e+00 | 4.0e-02 | CCND1,COL2A1,HMGA1,PARP1 | NA |
| PCYT2 | -1.70e-01 | enzyme | NA | 1.00e+00 | 4.0e-02 | CIDEC,GPAM,NR1H3,SREBF1 | NA |
| asciminib | NA | chemical drug | NA | 1.00e+00 | 4.0e-02 | ATAD2,MCM3,MCM4,PRKDC | NA |
| miR-26a-5p (and other miRNAs w/seed UCAAGUA) | NA | mature microRNA | NA | 1.00e+00 | 5.0e-02 | CCNE1,CDKN1A,CHORDC1,EZH2,FGF9,MAP2 | NA |
| OSM | 6.80e-01 | cytokine | NA | 1.00e+00 | 0.0e+00 | ABCC4,ABCC8,ACE,ACSL3,ADAMTS1,ADAMTS4,ANGPTL4,ARF6,ARHGAP32,ASNS,BAIAP2,BAMBI,BCL2L11,BCL3,BHLHE40,CASK,CCL24,CCL5,CCND1,CDKN1A,CHD1,CISH,CLDN4,COL2A1,CPM,CRY1,CSF2RB,CSNK2A2,CXCL10,Cxcl3,DDX27,DHRS3,EPHB6,FMO5,FOSL1,GBP1,GMPR,GRIN2C,HK2,HSPA2,HSPA5,ICAM1,IER3,IFI35,IL15RA,IL18,IL1R2,IL33,IRF1,IRF7,IRF9,ISG20,JMJD1C,JUN,LDLRAD4,LY6D,MAGED2,MAP2,MPP2,MX1,NMB,NOMO1 (includes others),OSMR,PCNA,PDLIM5,PPP3CC,PTP4A1,RASD2,RORA,SCNN1B,SERPINE1,SLC16A1,SLC39A7,SMPD1,SOCS1,SORD,STAT1,STAT3,STX11,TIMP3,TLR2,TLR3,TNC,UBE2G1,VDR,WNT5A,ZNF467 | 708 (20) |
| nitric oxide | NA | chemical - endogenous mammalian | NA | 1.00e+00 | 0.0e+00 | ACE,ARID1B,BIRC2,CCND1,CDKN1A,CXCL10,DUSP1,EPOR,FGF7,GADD45A,IER3,IL18,JUN,Mt1,NDRG1,NQO1,OPRD1,PDIA4,PRKDC,RAD23B,SLC23A2,TFRC,THBS1,TIMP3,TK1,TXNRD1,UBE2C,VCL | 745 (18) |
| WNT3A | 2.00e-01 | cytokine | NA | 9.90e-01 | 1.0e-02 | Acan,ADAM10,ADAMTS4,ANGPT1,AQP3,ARHGAP18,AXIN2,BCL2L11,BCS1L,Casp12,CCL5,CCND1,COL11A2,COL2A1,CXCL10,EGR2,EPAS1,EPHA5,FZD1,GAS1,HHIP,Irgm1,JUN,KLF4,LEF1,LGALS12,LGR5,Meis1,NDNF,NFATC1,NRG1,PEX5,PMEPA1,PROCR,PXYLP1,SIM1,SLC7A11,TFCP2L1,TGFB2,THBS1,TIMP3,TNC,WNT5A,ZNF703 | 675 (21) |
| Jnk | NA | group | NA | 9.80e-01 | 0.0e+00 | AGER,AGT,ATG7,BCL2L11,CCL5,CCND1,CCNE1,CD55,CD83,CD86,CLEC10A,DUSP1,E2F4,FBXO32,GADD45A,GJA1,HSPA5,ICAM1,IL19,JUN,MSH2,NQO1,PDGFB,PLAT,PLSCR1,RAD51,SERPINE1,TGM2,TINAGL1,TNFRSF10A,VCAN | 711 (17) |
| DETA-NONOate | NA | chemical reagent | NA | 9.80e-01 | 1.0e-02 | ADAM10,BIRC2,CA9,CAV1,CCND1,CDKN1A,DUSP1,ICAM1,IRF7,PDE3B,SERPINE1 | 705 (24) |
| ABL1 | 4.70e-01 | kinase | NA | 9.80e-01 | 1.0e-02 | BCL2L11,CAV1,CCND1,CCNE1,CDKN1A,GADD45A,IER3,SMPD1,TGFB2 | 721 (20) |
| N-[(2Z)-3-(4,5-dihydro-1,3-thiazol-2-yl)-1,3-thiazolidin-2-yl idene]-5H dibenzo[a,d][7]annulen-5-amine | NA | chemical reagent | NA | 9.80e-01 | 2.0e-02 | ADRB3,BCAR1,FXYD5,IL18,IRF9,MTHFD2,NCOA2,NR0B2,NR4A3,NRG1,SERPINE1,TFRC,TNFSF10 | NA |
| HEXIM1 | -2.20e-01 | transcription regulator | NA | 9.80e-01 | 2.0e-02 | ANGPT1,CCND1,CDKN1A,FGF9,PTBP1,TGFB2 | NA |
| N-Ac-Leu-Leu-norleucinal | NA | chemical - protease inhibitor | NA | 9.70e-01 | 0.0e+00 | ATF4,BCAR1,BCL2L11,CAV1,CCND1,CDC25A,CDKN1A,E2F4,EIF4E,GRIN1,ICAM1,IER3,KCNH2,MYCN,NEDD9,PAWR,SCARB1,Scd2,SREBF1 | 778 (22) |
| gamma-tocotrienol | NA | chemical drug | NA | 9.70e-01 | 3.0e-02 | CCND1,IL18,JUN,NLRP3 | NA |
| STAT5A | -1.20e-01 | transcription regulator | NA | 9.70e-01 | 0.0e+00 | ASCL2,ATM,AXIN2,CCND1,CCNE1,CDH17,CDKN1A,CEACAM1,CISH,CXCR3,CYP27B1,DUSP5,EPAS1,EPOR,ESR1,EZH2,GADD45A,GCHFR,HOXB6,ICAM1,IGFALS,IRF1,Klrk1,KRT80,LAMB3,LEF1,MAP1LC3A,MUC13,NR1H3,NR4A2,OLR1,RNF39,RORA,RPA1,SERP2,SLC7A7,SNTB1,SOCS1,SOCS2,SREBF1,TCEAL1,TLE4,TRAF1,TSPAN8,YBX1 | 612 (22) |
| WBP2 | 2.30e-01 | transcription regulator | NA | 9.70e-01 | 2.0e-02 | ALOXE3,ALPK1,AQP3,AXIN2,CORO1C,CTF1,DHX34,ESR1,HHIP,JUN,LEF1,LGR5,LIPG,NECTIN1,SLC7A11,TBCCD1,TK1,TLR3,TRAF1 | NA |
| carboplatin | NA | chemical drug | NA | 9.60e-01 | 0.0e+00 | ASNS,Bex2/LOC100912195,CDCP1,CLDN4,FXYD5,GTPBP4,IER3,LAMC2,MCM3,NT5E,PLA1A,RAD51,RBM3,UPP1 | 368 (7) |
| POR | 7.10e-01 | enzyme | NA | 9.60e-01 | 1.0e-02 | AASDH,ACAT2,ACTG1,ASNS,CAPRIN2,CHMP4C,CYB5B,CYP39A1,ELOVL5,FDFT1,GADD45B,GPHN,GREB1,HMGCS1,HSPH1,LSS,Mt1,NOCT,NR0B2,POR,RAB30,Scd2,SLC23A2,Slco1a4,STAT1,TMEM267 | NA |
| FDI6 | NA | chemical reagent | NA | 9.60e-01 | 1.0e-02 | CCND1,CDC25A,PARP1,PARP2,PLK1,RAD51 | NA |
| SMAD2 | -2.50e-01 | transcription regulator | NA | 9.60e-01 | 5.0e-02 | Acan,BCL2L11,CDKN1A,COL2A1,CRISPLD2,FDFT1,GADD45B,GNRHR,NET1,PDGFB,SERPINE1,SFTPB,SKIL,THBS1,TIMP3,VEGFC | NA |
| bee venom | NA | chemical - endogenous non-mammalian | NA | 9.60e-01 | 0.0e+00 | Arf2,CCL5,DDX27,DNAJB1,EHD1,GADD45A,HAS1,ICAM1,IPO5,IRF1,ITGA5,ITGAV,ITPKC,JUN,KLF4,MEFV,NFIL3,NLRP3,NR4A2,NUSAP1,PRC1,SERPINB2,SLC7A11,THBD,TRAF1,TSC22D1 | 549 (10) |
| ethionine | NA | chemical toxicant | NA | 9.60e-01 | 5.0e-02 | GTPBP4,IER3,LAMC2,MCM3,PLA1A,TSPAN8,UPP1 | NA |
| FGF2 | -7.70e-01 | growth factor | NA | 9.60e-01 | 0.0e+00 | ACE,AGL,AKR1B1,ANGPT1,ANGPTL4,ANPEP,AQP3,ATF4,AXIN2,BAMBI,BRIX1,CAV1,CCND1,CCNE1,CDC25A,CDKN1A,CIDEC,DLL1,EFNB2,ELN,EPAS1,EPOR,ETV1,FDX1,FOSL1,GADD45A,GAL,GBP1,GCH1,GJA1,GREM1,GRIA3,GRIN2C,HK2,HMGA1,ICAM1,ID3,ITGA5,JUN,Ldha/RGD1562690,LEF1,LOX,Meis1,MYCN,NR4A2,PCNA,PDGFB,PDGFC,PENK,PLAT,POLE2,PRKCD,PRKDC,PTPN1,RAD51,RET,RORA,SDC1,SERPINE1,TFCP2L1,TGFB2,TGFBR3,TH,THBS1,TIMP3,TNFSF10,VEGFC,VGF,WNT5A,XRCC6 | 699 (22) |
| methotrexate | NA | chemical drug | NA | 9.40e-01 | 0.0e+00 | ABCD1,ACTG1,AMD1,CCL5,CCND1,CDKN1A,CXCL10,CXCL11,CXCR3,DGAT1,DUSP1,DUSP14,ENO3,EPAS1,FADS1,FGF7,GPAM,HMGCS1,ICAM1,IL18,LILRB4,LIPC,MAPKAPK2,Mt1,NQO1,NR1H4,NR4A2,PBX1,PEX7,PLD2,PRKCB,SETD6,SFTPC,THBS1,TIMP3,TLR3 | 698 (17) |
| apatinib | NA | chemical drug | NA | 9.30e-01 | 1.0e-02 | ASNS,ATF4,PPAT,SLC36A4,SLC38A1,SLC38A9,SLC3A2,SLC7A11 | NA |
| UCN-01 | NA | chemical drug | NA | 9.30e-01 | 0.0e+00 | BCL2L11,CCND1,CDC25A,CDKN1A,PLK1,RRM2,XPA | 652 (23) |
| MRTFA | NA | transcription regulator | NA | 9.20e-01 | 0.0e+00 | ABLIM1,ACTG1,CCL5,CDC42EP2,CDC42EP3,CLDN15,EGR2,EGR3,ETV6,F11R,F2R,FSCN2,GADD45A,GAS1,ICAM1,ITGA5,LILRB4,MAFK,MAP2,Prss34,SCARB1,SERPINB2,SERPINE1,SLC6A4,STAT1,TGFB2,THBS1,TNC,Tpm4,VCL,WNT5A | 536 (14) |
| HIC1 | 0.00e+00 | transcription regulator | NA | 9.20e-01 | 1.0e-02 | ACKR3,BBOF1,CCND1,CDKN1A,CDKN1C,FADS1,ID4,KAZN,MAP2K3,MAP2K5,SLC7A11 | NA |
| NR1I2 | -8.50e-01 | ligand-dependent nuclear receptor | NA | 9.20e-01 | 1.0e-02 | ABCB10,AHCY,APOC2,CCL24,CDKN1A,CPOX,CYP39A1,FMO5,HMGCS1,IL20,IL33,JUN,LTBP1,NR0B2,NR1H4,PDIA4,POR,SCARB1,Slco1a4,SOCS1,SREBF1,STAT3,Sult1d1,TGM2,TLR3,UGT1A4 | NA |
| CYP27A1 | -5.50e-01 | enzyme | NA | 9.10e-01 | 3.0e-02 | AGT,ANPEP,HMGCS1,Slco1a4,SREBF1 | NA |
| CDK9 | 3.60e-01 | kinase | NA | 9.10e-01 | 4.0e-02 | CCL5,CDKN1A,MYBL2,NCL,NMD3,PTBP1,RAD1,STC2,WNT5A | NA |
| CHD4 | 1.10e-01 | enzyme | NA | 9.00e-01 | 0.0e+00 | ADORA1,ANGPTL4,CDKN1A,CHEK2,EZH2,ID4,JUN,LOX,Mslnl,NDNF,PDE1B,RAD51,RIPK4,RRM2,SOCS2 | 616 (15) |
| STIM1 | 8.00e-02 | ion channel | NA | 9.00e-01 | 3.0e-02 | AQP5,ATF4,CDKN1A,CREB3L1,FGF9,FOSL1,ITGA11,ITGA5,KLF4,MYBL2,NQO1 | NA |
| MAPK3 | 1.10e-01 | kinase | NA | 9.00e-01 | 1.0e-02 | ACE,BCL2L11,CCND1,CD86,CDKN1A,EGR2,ELN,ESR1,FOSL1,GNRHR,ITGA2,JUN,NPTX2,PDGFB,RET,THBS1,TNFRSF10A | 765 (22) |
| D-fructose | NA | chemical - endogenous mammalian | NA | 9.00e-01 | 1.0e-02 | AGER,AGT,CXCL10,ICAM1,SLC2A5,SLC5A1,SLC9A3,SREBF1,THBS1,TIMP3 | 781 (22) |
| NOTCH1 | 1.30e-01 | transcription regulator | NA | 9.00e-01 | 2.0e-02 | ANGPT1,AQP3,BIRC2,CCND1,CCNE1,CDKN1A,CDKN1C,CSF2RB,DLL1,DNAJA1,ECT2,EFNB2,EPAS1,FABP7,FOSL1,HK2,HSPH1,ICAM1,IFI16,IL18,IRF1,ITGA2B,LEF1,LOX,MYCN,NRG1,PDGFB,PROX1,REN,SERPINE1,SOCS1,TGFB2,TGFBR3,TH,WNT5A | NA |
| FANCC | -6.60e-01 | other | NA | 9.00e-01 | 0.0e+00 | ANKRD6,AXIN2,CASK,DLG2,FZD9,IFI44L,MX1,MYOF,PRKCB,PROX1,SKAP2,SNX7,TBC1D9,TOM1L1,WNT5A | NA |
| V-PYRRO/NO | NA | chemical reagent | NA | 9.00e-01 | 1.0e-02 | BAD,ICAM1,JUN,THBS1,TNFSF10,TRADD | NA |
| ZBTB18 | NA | transcription regulator | NA | 9.00e-01 | 2.0e-02 | C1QTNF1,IGDCC4,KANK2,LAMC2,PIK3R5,SERPINH1 | NA |
| DMRT1 | NA | transcription regulator | NA | 9.00e-01 | 2.0e-02 | ATP13A4,CLEC12B,CTRB2,DMRT2,E2F4,HOXB7,MAP2K3,Meis1,NCOA2,NR1H3,P4HA1,RET,TOX2,VCL,VRK1 | NA |
| ACVRL1 | 4.10e-01 | kinase | NA | 9.00e-01 | 3.0e-02 | CDKN1A,EFNB2,ICAM1,JUP,PLAT,SERPINE1,STAT1 | NA |
| CD3 group | NA | group | NA | 9.00e-01 | 4.0e-02 | ACSL3,CCNE1,EGR2,HK2,LPCAT2,PLA2G4B,SLC7A5,STAT3,TFRC | NA |
| GNRH | NA | group | NA | 9.00e-01 | 4.0e-02 | BMP7,DUSP1,GNRHR,INHA,JUN,SCG3,VGF | NA |
| crocidolite asbestos | NA | chemical toxicant | NA | 8.90e-01 | 4.0e-02 | BCAT1,CCND1,FOSL1,GADD45A,JUN,PRKCD | NA |
| RB1CC1 | 1.30e-01 | other | NA | 8.90e-01 | 0.0e+00 | CCL5,CCND1,CDKN1A,CXCL10,SERPINE1,SKIL | 638 (20) |
| IL33 | 2.22e+00 | cytokine | NA | 8.90e-01 | 0.0e+00 | ADAMTS1,ATP10A,ATXN1,BCL2L11,BCL3,CCL5,CCND1,CD200R1,CD83,CD86,CISH,CLEC7A,CSF2RB,CSTB,CX3CL1,CXCL10,Cxcl3,DGAT1,EGR2,EGR3,EHD1,EPAS1,FGR,FTL,GADD45B,GCHFR,ICAM1,IER3,IL33,IRF7,ITGA5,ITGAX,JAK2,KLF4,LAMA5,LILRB4,NFATC1,NFIL3,NFKBIB,NLRP3,NPHS2,NT5E,P4HA1,PDGFB,PIK3R5,PLA2G4F,PLAT,RAI14,RGS10,SCARB1,SERPINB2,SERPINE1,SFTPC,SKIL,SLC7A11,ST3GAL5,STX11,TLR2,TNFSF10,TPSAB1/TPSB2,TRAF1,TUBB6,VASH1,VEGFC | 723 (17) |
| captopril | NA | chemical drug | NA | 8.80e-01 | 1.0e-02 | ACE,AGT,Akr1b7,ASNS,CSRP2,GTPBP4,IER3,LAMC2,MCM3,RBM3,REN,TGFB2,TSPAN8,UPP1 | 510 (9) |
| EP400 | -5.00e-02 | other | NA | 8.80e-01 | 0.0e+00 | CCNF,CDC25A,CDKN1A,MCM3,MCM4,MYBL2,NCAPG2,PCNA,PLK1,RASSF1,SKP2 | 117 (5) |
| CCND1 | -7.20e-01 | transcription regulator | NA | 8.80e-01 | 0.0e+00 | ABCC4,AQP3,ATAD2,AURKA,CCND1,CCNE1,CDKN1A,COL20A1,CPED1,E2F4,ELOVL7,FGF7,FZD7,GPRC5A,HSPA1A/HSPA1B,HSPB8,ID3,IER3,ITGAV,KLHDC1,KNL1,LASP1,MAFF,MAP3K5,MBLAC2,MCM4,NOP58,NT5E,PAH,PCNA,PDLIM3,PLK1,PMEPA1,PRIM2,RAD51,RRM2,SATB1,SOX11,STBD1,TBCK,THNSL1,TIAM1,TUBA1C,ZNF462 | 483 (13) |
| SULF2 | -2.70e-01 | enzyme | NA | 8.70e-01 | 0.0e+00 | Acan,AXIN2,BAD,CCND1,COL2A1,FLT3,PDGFB,SOCS2 | 680 (16) |
| EIF3A | 5.40e-01 | translation regulator | NA | 8.60e-01 | 1.0e-02 | NDRG1,RAD23B,RPA1,XPA | NA |
| IL10 | -3.00e-02 | cytokine | NA | 8.60e-01 | 0.0e+00 | AGER,ARAP2,BCL2L11,BCL3,CCL5,Ccl6,CD55,CD83,CD86,CDKN1A,CEACAM1,CIT,CLEC7A,CSF2RB,CXCL10,CXCL11,CXCR3,DUSP1,GPRC5B,HLA-G,HTATIP2,ICAM1,Igtp,IL18,IL1R2,IL33,IRF1,JUN,LILRB4,MEFV,MERTK,MYBL2,NEDD9,NFATC1,NR4A3,NT5E,PAK1,PDE4B,PLK1,PTPN1,RAB20,SCARB1,SCGB3A2,SERPINB2,SLC6A4,SLC7A5,SOCS1,STAT1,STAT3,STX11,TFRC,TINAGL1,TLR2,TLR3,TLR5,TNFSF10,TUBB4B,VCAN | 732 (18) |
| BV6 | NA | chemical reagent | NA | 8.60e-01 | 3.0e-02 | BIRC2,CCL5,CD83,CD86 | NA |
| JAK2 | -1.12e+00 | kinase | NA | 8.60e-01 | 0.0e+00 | ACE,BCL2L11,BMP7,CCL5,CCND1,CDC25A,CDKN1A,CEP112,CXCL10,EPOR,ESR1,Fhod1,ICAM1,IL19,IRF1,ITGA5,JAK2,OSMR,PHLDA3,PRKCB,SERPINH1,SKIL,SOCS1,STAT1,STAT3,TGM2,THBS1,TSC22D1 | 681 (21) |
| NR3C2 | -5.90e-01 | ligand-dependent nuclear receptor | NA | 8.60e-01 | 4.0e-02 | ADAMTS1,AGT,CCL5,GPR83,ICAM1,MAP2,MLF1,NFIA,NR4A2,NRIP3,PLAT,PLIN4,PPAT,PROCR,RAPGEF4,SCNN1A,SERP2,SERPINE1,TGM2 | NA |
| tetrachlorodibenzodioxin | NA | chemical toxicant | NA | 8.50e-01 | 0.0e+00 | ACSL3,AKR1B1,ANGPT1,AQP3,ASNS,ATF4,ATOH8,BCAT1,C11orf24,CALN1,CCL5,CCND1,CCNE1,CD86,CDKN1A,CDKN1C,CEBPZ,CFTR,COL18A1,DMXL2,ELN,ESR1,FGF9,FZD7,GADD45B,GAS1,GLRX,GRIN1,HDAC1,HDAC11,HDAC4,HDAC5,HSPA1A/HSPA1B,HSPA2,ID3,IDH1,IRF1,ITGA5,ITGAX,JAK2,JUN,KCNA5,KCNJ5,LIPC,LRP2,MAD2L1,MDFI,MICOS10-NBL1/NBL1,MMAB,MMP15,MYO10,NAT2,NEDD9,NQO1,NR0B2,PCNA,PDE4B,PPAN,PRKCB,PTGFR,RNGTT,RPIA,SDC1,SERPINB2,SERPINE1,SERPINH1,SIM1,SLC23A2,SLC7A5,Slco1a4,SNAPC2,SOCS2,STC2,TGFB2,TGM1,TH,THBS1,TK1,TNC,UGT1A4,VEGFC | 806 (20) |
| T-5224 | NA | chemical reagent | NA | 8.50e-01 | 0.0e+00 | ADAMTS1,ANGPTL4,APPL2,ATF4,CDK19,CPM,CRISPLD2,FGF12,GADD45B,HMGCS1,IFI16,JUN,LSS,PRKX,PRRG1,RAB11FIP3,SLCO2A1,SMARCA1,TMEM164,TNFRSF21,TRIB1,TTC39B | NA |
| CASR | -1.40e-01 | G-protein coupled receptor | NA | 8.50e-01 | 0.0e+00 | Acan,BMP7,CCND1,CISH,CXCL10,EZH2,GADD45A,IER3,MAD2L1,NEDD9,NFATC1,NUSAP1,PDLIM2,PRC1,SLC7A7,TGFB2,THBD,TK1,TLR2,UCP2,VCL,VDR | 679 (22) |
| LMNB1 | 5.30e-01 | other | NA | 8.50e-01 | 1.0e-02 | ACTN4,ELOVL7,FLT3,GJA1,GPC4,HMGCS1,PCNA,POLM,RAD51,TGFB2 | NA |
| FSHR | NA | G-protein coupled receptor | NA | 8.50e-01 | 2.0e-02 | CD55,CX3CL1,DUSP1,FDX1,GDE1,INHA,INHBB,MSI1,PLA1A,PLAT | NA |
| AQP1 | 1.30e-01 | transporter | NA | 8.50e-01 | 4.0e-02 | AKR1B1,AVPR2,HSPH1,TH | NA |
| miR-291a-3p (and other miRNAs w/seed AAGUGCU) | NA | mature microRNA | NA | 8.40e-01 | 1.0e-02 | CCND1,CD83,CDK19,CDKN1A,ESR1,FYCO1,GLTP,HSPA14,NR4A2,PRC1,PRKACB,RNF149,RPIA,STX11,TFAP4,TTC8 | NA |
| USF1 | -2.40e-01 | transcription regulator | NA | 8.40e-01 | 2.0e-02 | AGT,CEACAM1,DUSP1,FBXO32,GHRL,GPAM,HDAC4,HK2,Mt1,OPRD1,P4HA1,REN,SERPINE1,UCP2 | NA |
| (+)-MK-801 | NA | chemical drug | NA | 8.40e-01 | 0.0e+00 | ATP2B2,AVPR2,CCND1,CDKN1A,GJA1,GJA4,GRIN1,HSPA1A/HSPA1B,HSPA5,ICAM1,INPP4B,ITGA2B,JUN,NPTXR,PPP2CB,STAT3 | 698 (21) |
| SKIL | 7.20e-01 | transcription regulator | NA | 8.40e-01 | 3.0e-02 | CDKN1A,CDKN2AIPNL,CLDND1,HNRNPA1,NETO2,PLSCR1,SERPINE1,SKIL | NA |
| sorafenib | NA | chemical drug | NA | 8.40e-01 | 1.0e-02 | ATF4,CCL5,CCND1,CDC25A,CISH,CXCL10,HSPA5,SLC7A11,SOCS1,SREBF1 | 573 (15) |
| palmitic acid | NA | chemical - endogenous mammalian | NA | 8.30e-01 | 0.0e+00 | ATF4,ATG7,BCL2L11,Casp12,CCL5,CD86,CDKN1A,CNR1,CXCL10,FBXO32,GLP1R,HIBCH,HK2,HNF1A,HSPA5,ICAM1,IDE,IRAK2,JUN,KDSR,KLF4,LEP,MAP1LC3A,Mt1,NDUFA5,NMU,NR0B2,NR4A2,NR4A3,NSFL1C,OLR1,PNPLA2,PPP2R2B,PROCR,PTPN1,RAD23B,SCARB1,SERPINE1,SREBF1,TFRC,THBD,TLR2,TNFSF10,TRIM63,UCP2,USP7,ZDHHC12 | 695 (24) |
| SIRT1 | -2.10e-01 | transcription regulator | NA | 8.30e-01 | 0.0e+00 | Acan,AGT,CAV1,CCL5,CCND1,CD83,CDKN1A,CLEC10A,CNR1,COL2A1,DHX58,EPAS1,ERMP1,ESR1,FBXO32,FBXO39,FGF7,GADD45A,HCRTR2,HELZ2,HK2,HSPA5,ICAM1,IFI44,Ifi47,Igtp,IRF7,Irgm1,KDM5B,LEF1,LEP,MLH1,MTHFD1L,NDUFA5,NECTIN4,NEURL1,NR1D1,NR1H4,NT5E,OAS2,Oasl2,PARP1,PARP14,PCNA,PML,PRDM16,RBPJL,RNF213,RNF39,RTP4,Scd2,Scd3,SCNN1A,SCX,SEC61A1,SERPINE1,SHANK2,SLC27A6,SLC7A11,SP110,SREBF1,STAT1,STAT3,TGM2,THBD,TIMP3,TMPRSS4,TRIM63,UCP2,USP18 | 692 (21) |
| TIMP3 | 7.60e-01 | other | NA | 8.30e-01 | 0.0e+00 | ADAM10,BAMBI,EGR2,JUN,KLF4,LAMC2,LTBP1,SERPINE1,SKIL,STAT1,STAT3,TGFBR3,THBS1 | 756 (22) |
| HNF1A | -9.10e-01 | transcription regulator | NA | 8.30e-01 | 3.0e-02 | ACAT2,ADAM32,ADCY10,AGT,ALS2,ANPEP,AP3M1,AQP3,ATG4C,ATP4A,BCL6B,CCND1,CCNE1,CD55,CLIC5,CYB5B,FMO1,FOXJ3,FUT10,FUT7,GAL,GLP1R,GSTCD,HNF1A,HOPX,HSPA5,IGFALS,LEF1,MID1IP1,MON1B,MSH5,MTHFD1,NPTX2,NR0B2,NR1D1,NR1H4,PAH,PATJ,PLA1A,RNGTT,SEMA4A,SERPINE1,SLC26A1,SLC5A1,Slco1a4,SSTR1,STN1,Sult1d1,TFRC,TMPRSS4,UCP2,VIL1,WDFY2,WDR12 | NA |
| letrozole | NA | chemical drug | NA | 8.30e-01 | 5.0e-02 | CCND1,CDKN1A,ESR1,FOSL1,GJA1,GNRHR | NA |
| mir-17 | NA | microRNA | NA | 8.30e-01 | 3.0e-02 | ATM,BCL2L11,BIRC2,CAPRIN2,CCND1,CDKN1A,ESR1,FGF9,LEF1,MAP2K3,MAP3K5,RBL2,STAT3,THBS1 | NA |
| NRAS | 6.00e-02 | enzyme | NA | 8.30e-01 | 0.0e+00 | AK1,CCL5,CCND1,CCNE1,CD86,CDKN1A,CEACAM1,CX3CL1,EPAS1,ERCC5,ETV1,FLT3,GJA1,IFI16,IFI35,IFIH1,Irgm1,ITGA2,MCM3,MYBL2,NQO1,PENK,PHLDA3,PKIA,POLD1,SCX,SDC1,SKP2,STAT1,STAT3,SV2B,TMEM43,TUBB2A,UBE2C,USP18,ZNF703 | 706 (21) |
| fenofibrate | NA | chemical drug | NA | 8.20e-01 | 0.0e+00 | ACSL3,ANGPTL4,AP3M1,APOC2,ASNS,BCL2L11,CCND1,CD200,CDC25A,DGAT1,FABP7,FBXO32,GADD45A,GPAM,GYG1,HSPA5,ICAM1,JUN,Ldha/RGD1562690,LY6D,MLH1,MPDZ,MYBL2,NR1H3,PCNA,PNPLA2,POLD1,POR,RORA,SCARB1,SERPINE1,SREBF1,STAT3,TIAM1,TRIM63,UCP2,UCP3,UGT1A4,XRCC4 | 919 (26) |
| APP | 4.00e-01 | other | NA | 8.20e-01 | 0.0e+00 | ACTG1,ADAM10,ADAMTS4,AGER,AK1,APBB1,APPBP2,ARF4,ARF6,ASCC1,ATF1,ATF4,ATG7,ATM,ATP2B2,ATP4A,ATP6V1E1,AXIN2,BAD,BCL2L11,BIN1,Bmp8b,BRPF1,CALML3,Casp12,CCL5,CCND1,CCNE1,CD86,CDK5RAP2,CDKN1A,CKB,COL18A1,CPLX1,CSF2RB,CSNK2A2,CXCL10,DNAJC5,ELMOD3,ELN,ELOVL4,EPAS1,ERMP1,ESR1,EXT1,F2RL3,Fus,FZD1,FZD7,GBP4,GRIN1,HDAC1,HDAC11,HDAC4,HEATR5A,HMGA1,HNRNPA1,HSPA1A/HSPA1B,HSPA5,ICAM1,IDE,IFI16,IFI35,Ifi47,IFIH1,Igtp,IL18,IRF1,IRF7,Irgm1,ISG20,ITGA2,JUN,L1CAM,LDB2,LEF1,MAFF,MAP2,MAP6,MAPKAPK2,Meis1,MERTK,Mt1,MTHFD1L,NDUFA5,NFATC1,NLRP3,NOS1,NR1D1,NR4A2,NRG1,Oas1b,OLR1,PAK1,PARP14,PDE4B,PDGFB,PDK2,PENK,PLAT,PLK1,PRIMA1,PRKCB,PRKDC,PRMT1,RAD52,RAD9A,RBM3,RNF213,RTP4,SAP30,SATB1,SCARB1,Serpinb6b,SERPINE1,SIRT4,SLC13A3,SLC7A11,SLFN13,SLFN5,SMARCA2,SOCS1,ST3GAL5,STAT3,STXBP4,TH,TLR2,TLR3,TLR5,TNFRSF10A,TNFSF10,TPT1,TRIM21,TUBA1C,TUBB2A,TUBB4B,TUBB6,USP18,VCAN | 543 (20) |
| Pka | NA | complex | NA | 8.20e-01 | 3.0e-02 | CAV1,CDKN1A,CXCL10,DUSP1,GHRL,GJA1,IRF1,JUN,LEP,NCOA2,NR4A2,NR4A3,OXTR,PDE4B,PDE4D,PENK,REN,SFTPB,SREBF1 | NA |
| ZFP91 | 7.00e-02 | transcription regulator | NA | 8.20e-01 | 0.0e+00 | BCAT1,HK2,IFI16,MAD2L1,RRM2,Scd2 | NA |
| CREM | -1.00e-02 | transcription regulator | NA | 8.20e-01 | 1.0e-02 | ACE,ATP2A2,BHLHE40,CCND1,CD86,DIO2,DUSP1,DUSP14,EGR2,FRMD6,FUT7,GADD45B,HMGCS1,INHA,LSS,NFATC1,NFIL3,NOS1,NR4A2,REN,SLC16A1,TH,THBS1 | 715 (22) |
| MEIS2 | 2.40e-01 | transcription regulator | NA | 8.20e-01 | 2.0e-02 | ETV1,ID3,OSR1,PBX1,SOX11,WNT5A | NA |
| NMU | 1.19e+00 | other | NA | 8.20e-01 | 3.0e-02 | ATF4,DIO2,IL1R2,LEP,Mt1,NMU | NA |
| ADAMTS18 | NA | peptidase | NA | 8.20e-01 | 4.0e-02 | CLDN4,Col17a1,LAMB3,LAMC2,MMP15,SCUBE3 | NA |
| thalidomide | NA | chemical drug | NA | 8.20e-01 | 4.0e-02 | ANGPT1,CAV1,GADD45B,ICAM1,PDGFB,SERPINE1,TRAF1 | NA |
| GATA2 | -2.40e-01 | transcription regulator | NA | 8.10e-01 | 4.0e-02 | AK1,ANGPT1,ARPP21,CCL5,CCND1,Ccnjl,CDKN1A,CELSR3,CLDN18,Col17a1,CTRB2,CX3CL1,CXCL10,Cxcl3,DDIT4L,DIO2,DLL1,EPOR,ETV6,F2R,FUT7,GFRA1,GNRHR,GREM1,ICAM1,ITGA2,ITGA2B,KHDC1L,KLF4,LY6D,LYPD6B,MFSD2B,NFIL3,PBX1,PHLDA3,Prss34,S100G,SERPINB2,Serpinb6b,SKP2,TFRC,TGFBR3,TGM2,THBS1,TMEM44,TPSAB1/TPSB2,VEGFC,ZNF462 | NA |
| tacrolimus | NA | chemical drug | NA | 8.10e-01 | 0.0e+00 | ABLIM1,ANGPT1,BCL2L11,CCL5,CCND1,CD200,CISH,COL2A1,CXCL10,CXCR3,DPYSL5,ESR1,ETV1,GNPDA1,GPR83,GPRC5B,GRIN2C,ID3,IL1R2,IL33,JUN,LAT,LILRB4,MARCKSL1,NFATC1,NOS1,NT5E,OSBPL3,OSCAR,PDE3B,PENK,PRKACB,PROM1,RRP12,SLC12A5,TGFBR3,TIAM1,TNC,TNFSF10,UNC119,VEGFC | 808 (23) |
| acrolein | NA | chemical toxicant | NA | 8.10e-01 | 4.0e-02 | ADAM10,CCND1,MLH1,OGG1,XPA | NA |
| LIN9 | -2.30e-01 | other | NA | 8.10e-01 | 1.0e-02 | AURKA,CDKN1A,MYBL2,PLK1,TMPO,UBE2C | NA |
| FABP5 | 5.20e-01 | transporter | NA | 8.10e-01 | 3.0e-02 | GADD45B,ISG20,LEP,Oas1b,RORA,TRAF1 | NA |
| estrogen | NA | chemical drug | NA | 8.10e-01 | 0.0e+00 | AGT,AURKA,BCL3,BOP1,CCND1,CDC25A,CDKN1A,CFTR,CKB,COL18A1,Crabp2,CRY2,DUSP1,EPAS1,ESR1,FGF7,GAL,GJA1,GNRHR,GREB1,HSPH1,ICAM1,ITGA5,JUN,KCNH1,LIPC,MCM3,MCM4,NFIL3,NOS1,OXTR,PCNA,PENK,PLAT,PLIN4,POLD1,PPRC1,PRDM15,RET,RRM2,S100G,SCARB1,SCX,SFTPB,SKP2,SLC6A4,SMC2,SSTR1,STAT1,STAT3,TGFB2,VDR | 752 (21) |
| FGFR2 | 4.20e-01 | kinase | NA | 8.00e-01 | 4.0e-02 | AMN,BMPER,CCND1,CDKN1A,DLL1,FLRT3,GJA1,GRB10,HHIP,ICAM1,INHBB,KBTBD11,LGR5,MRAS,S100G,SOX7,TSPAN8,VEGFC | NA |
| IL31 | NA | other | NA | 8.00e-01 | 0.0e+00 | CD86,CISH,IL33,MCM4,SOCS1,SOCS2,VGF | 709 (18) |
| bortezomib | NA | chemical drug | NA | 7.90e-01 | 0.0e+00 | ATF4,AURKA,BAD,BCL2L11,BIRC2,CAV1,CCL5,CCND1,CDKN1A,CSF2RB,CXCL10,DCAF12,DNAJA1,DNAJB1,DNAJB6,E2F4,ESR1,FANCC,FANCG,GADD45A,GADD45B,GREB1,HDAC1,HSPA14,HSPA1A/HSPA1B,HSPA5,ICAM1,IL10RB,IL33,MX1,NSFL1C,PCNA,RAD51,RAD51C,SDC1,SH3BP2,SREBF1,TNFRSF10A,TNFSF10 | 687 (18) |
| miR-223-3p (miRNAs w/seed GUCAGUU) | NA | mature microRNA | NA | 7.90e-01 | 3.0e-02 | CCND1,CCNE1,NFIA,NLRP3,STAT3,TGFBR3 | NA |
| trovafloxacin | NA | chemical drug | NA | 7.80e-01 | 0.0e+00 | BHLHE40,CDKN1A,Cxcl3,ICAM1,Igtp,IRF1,ISG20,PDE4B,RDX,SERPINE1,SOCS2,STAT3,TGM2,THBS1,UBE2I | 675 (13) |
| LEPR | -1.80e-01 | transmembrane receptor | NA | 7.60e-01 | 2.0e-02 | ADRB3,ANGPTL4,ATP2A2,CNR1,GADD45B,GPAM,HSPA1A/HSPA1B,HSPA5,IL1R2,LEP,LIPC,MMP19,PLCB3,PRMT1,PROM1,SCARB1,SERPINE1,SOCS2,SREBF1,STAT2,STAT3,TIMP3,TPRA1,TRPV1,UCP2,VGF | NA |
| romidepsin | NA | biologic drug | NA | 7.60e-01 | 0.0e+00 | ARF4,BCL2L11,BIRC2,CASZ1,CCL5,CCND1,CD86,CDKN1A,CXCL10,DUSP1,ESR1,EZH2,ICAM1,ITGAV,JUN,MED26,MLH1,NF2,PARP1,RAB3IP,SERPINB2,TIMP3 | 739 (23) |
| IDO1 | NA | enzyme | NA | 7.60e-01 | 1.0e-02 | CD86,HLA-G,ITGAX,SLC3A2,SLC7A11,SLC7A5 | 514 (7) |
| CNR1 | -1.36e+00 | G-protein coupled receptor | NA | 7.60e-01 | 2.0e-02 | ADORA1,ADRB3,APBB1,BMP7,Bmp8b,CA9,CEACAM1,CNR1,CXCL10,DLL1,HAGH,LEP,LIPC,NPHS2,PCNA,PENK,PLSCR1,SCARB1,SREBF1,STAT3,VEGFC | NA |
| ADCYAP1 | -3.50e-01 | other | NA | 7.60e-01 | 0.0e+00 | AGER,ANGPT1,Bex2/LOC100912195,CCBE1,CCL5,CD86,CHGB,CXCL10,DIO2,DLL3,EGR2,EGR3,GALNT7,GAS1,GNRHR,GREB1,ID3,IER3,IRF1,KLHL40,NOS1,NQO1,PDE10A,POR,PPP1R3B,RAB3IP,SCARB1,TGFB2,TK1,TMPO,TSC22D1,TXNRD1,UCP2 | 786 (19) |
| camptothecin | NA | chemical drug | NA | 7.50e-01 | 0.0e+00 | AGER,APBB2,APPBP2,ARAP2,ATM,AURKA,BAD,BAMBI,BIRC2,BTG3,CCND1,CCNE1,CCRL2,CD200,CD83,CD86,CDC25A,CDC42EP2,CDKN1A,CHAC1,DDB2,DNAJA1,EGR2,ENO3,EPOR,FCHSD2,FSCN1,FZD7,GADD45A,GADD45B,GDE1,GPHN,GRB10,GRIA3,GSDMD,HLA-G,HSPA1A/HSPA1B,HSPA2,HSPA5,HSPB8,HSPH1,ICAM1,ID3,IFI16,IL15RA,IL18,IRF1,JUN,LAT,LDLRAD4,LILRB4,MAD1L1,MAFF,MAP2K5,MARCKSL1,MERTK,MICAL3,Mt1,MYO10,MYO18A,NCL,NECTIN1,NLRP3,NR4A2,PBX1,PCNA,PLD2,PPIF,PRKDC,PTP4A1,PTPN1,PTPRN,RDX,RGS3,RNGTT,RRM2,SDC1,SERPINB2,SERPINE1,SERPINH1,SFTPC,SIRT4,SKIL,SLC30A1,SOCS1,STC2,STX11,TBC1D31,TFRC,THBD,TLR2,TNFRSF10A,TRA2A,TRAF1,TRIB1,TUBB2A,TWF2,TYK2,UGCG,UTP3,XRCC4 | 675 (18) |
| MYBL2 | 7.10e-01 | transcription regulator | NA | 7.50e-01 | 1.0e-02 | AURKA,BCL2L11,CCND1,ELN,FLT3,MAD1L1,MYBL2,PLK1,RRM2,UBE2C | 490 (15) |
| E. coli serotype 0127B8 lipopolysaccharide | NA | chemical - endogenous non-mammalian | NA | 7.50e-01 | 0.0e+00 | ADGRA1,ADGRG2,ADORA1,CAV1,CCL5,CCRL2,CXCL10,DIO2,EGR2,ELN,F2R,FAM107A,FGF12,FZD1,GJA1,GMPR,GPR146,GPR158,GPR83,GPRC5B,HSPA5,Ifi47,IRF1,JAK2,LAMC2,LOX,MEFV,P2RY14,PDGFB,SEMA4A,SLC7A11,SLC7A5,STAT1,STAT2,STAT3,TGFBR3,TLR2,TLR3 | 653 (17) |
| bicuculline | NA | chemical - endogenous non-mammalian | NA | 7.40e-01 | 0.0e+00 | DUSP1,EGR2,GADD45B,HK2,JUN,KLF4,MAFF,mir-154,NPTX2,NR4A2,TGFB2,TRIM21,USP8 | 715 (20) |
| CBFB | -5.30e-01 | transcription regulator | NA | 7.40e-01 | 4.0e-02 | ATF4,BCL2L11,DSP,GPR83,ICAM1,ITGA2B,KCNK5,PDE3B,PRRG1,RAB3IP,SOCS2,TGFBR3,TPSAB1/TPSB2 | NA |
| SRC | 1.10e-01 | kinase | NA | 7.30e-01 | 1.0e-02 | CAV1,CCND1,CCNE1,CDKN1A,CXCL10,DUSP1,F2R,FGR,FOSL1,GBP1,GJA1,HAS1,ICAM1,JUN,PLAT,PLK1,PRKCD,SCARB1,STAT3,VEGFC | 711 (21) |
| SMARCA4 | -8.00e-02 | transcription regulator | NA | 7.20e-01 | 0.0e+00 | ACE,ACTN4,AGT,ARL16,ASCC1,ASNS,ATP6V1B1,AXIN2,BAMBI,BIN1,CCND1,CCRL2,CDC25A,CDKN1A,CEACAM1,CHEK2,CLDND1,CPM,CUL4A,CXCR3,DGKG,DLL1,ENO3,EVA1A,FCHSD2,FGF9,GADD45A,GADD45B,GBP1,GCHFR,GPR158,GPR83,HAPLN3,HDAC4,HHIP,ICAM1,ID3,IER3,IFI16,IL15RA,IRF1,IRF6,ITGA5,ITGAV,JUN,KCNJ2,KIFAP3,KIFC3,LAMC2,LEF1,LOX,LRAT,MAFF,Mt1,NAP1L3,NECTIN1,NRIP3,NT5E,NUAK2,PDE4B,PKIA,PLAT,PLPP3,PTP4A1,RAD1,RASSF1,RRM2,SERPINB2,SERPINE1,SERPINH1,SFTPB,SFTPC,SKAP2,SLC23A2,SMARCA2,SNAPC2,SOCS2,STAMBPL1,STK33,TAOK3,TEC,TGFB2,TLR2,TNFSF10,TPK1,TRIM15,TRIM36,TSPAN8,TXNRD1 | 717 (23) |
| Go 6976 | NA | chemical drug | NA | 7.20e-01 | 2.0e-02 | CCL5,CCND1,CD55,CD83,CDKN1A,CHGB,CXCL10,HDAC5,ITGA5,NR4A2,TRAF1 | NA |
| C3AR1 | -2.50e-01 | G-protein coupled receptor | NA | 7.10e-01 | 1.0e-02 | CCL5,CD55,CD86,CXCL10,HSPA5,LTBP1,MEFV,SERPINE1,SREBF1,TGFB2 | 730 (17) |
| HNRNPU | -2.80e-01 | transporter | NA | 7.10e-01 | 5.0e-02 | IFIH1,IL18,INHA,INHBB,IRF7,Oasl2,OSR1,PDGFD,SOX8,TGFB2 | NA |
| BMS-690514 | NA | chemical drug | NA | 7.10e-01 | 1.0e-02 | BCL2L11,CCND1,CDKN1C,DNAJB6,HSPH1,MCM3,MCM4,PCNA | 623 (11) |
| PTC-209 | NA | chemical reagent | NA | 7.10e-01 | 4.0e-02 | CDKN1A,CGNL1,ELN,HOPX,KCNJ5,LOXL3,PKP2,RND1 | NA |
| CFTR | 1.23e+00 | ion channel | NA | 7.00e-01 | 5.0e-02 | ASNS,CAV1,CCL5,CFTR,Cyp3a25 (includes others),FADS1,FDFT1,GML,KCNJ1,POR,Scd2,SLC9A3,STAT1 | NA |
| WT1 | 1.50e-01 | transcription regulator | NA | 6.90e-01 | 0.0e+00 | AHCY,ANPEP,ANXA11,ASNS,CCL24,CCND1,CCNE1,CDKN1A,CLIC4,CUL4A,CX3CL1,CXCL10,EPOR,ESR1,EXT2,FDFT1,GRB10,HNRNPL,INHA,JUP,KLF4,LSS,MYCN,NDRG1,NR4A2,PDIA4,Scd2,SDC1,SERPINE1,SLC15A2,THBS1,TIMP3,TNFSF10,TRIM21,TSC22D1,VDR,YBX1,ZMIZ1 | 710 (26) |
| budesonide | NA | chemical drug | NA | 6.80e-01 | 1.0e-02 | ABLIM1,ACTG1,AHCY,BCL2L11,BRAF,BTG3,CAB39L,CCL5,CDKN1A,CGNL1,CPPED1,CXCL10,ECT2,ERCC5,GNA15,IL18,ING1,INPP4B,JUN,KAT2B,LDB2,LOX,MAD2L1,MAP2K3,MEGF9,MTHFD1L,PCNA,PLEKHM1,PSD3,RFFL,RIOK3,SCNN1B,STRADB,TIAM1,TLR2,TPRG1,TPSAB1/TPSB2,TUBB2A,WNT5A | 601 (14) |
| GLI2 | 2.00e-01 | transcription regulator | NA | 6.80e-01 | 3.0e-02 | CCL24,CCL5,CCND1,CDKN1A,CLEC7A,CXCL10,CXCR3,HHIP,HK2,IRF6,MLH1,MYCN,TFAP4,TGFB2,UGCG,VDR,WNT5A | NA |
| SGK1 | 1.90e-01 | kinase | NA | 6.70e-01 | 0.0e+00 | ASIC1,BCL2L11,CDKN1A,CFTR,KCNA5,KCNJ1,ORAI1,RBL2,SCNN1A,SCNN1B,SCNN1G,SLC15A2,SLC1A7,SLC3A2,SLC5A1,SLC9A3,TRPV6 | 653 (12) |
| Calcineurin protein(s) | NA | complex | NA | 6.70e-01 | 1.0e-02 | AQP5,ATP2A2,BCL2L11,CCL5,DUSP1,DUSP14,EGR2,NFIL3,NR4A2,NR4A3,RNF128,SERPINE1,STAT3 | 738 (24) |
| BMP10 | -3.00e-02 | growth factor | NA | 6.70e-01 | 3.0e-02 | ANGPT1,ANGPTL4,CD55,CD83,EGR2,HAS1,ICAM1,ID3,NR4A2,NR4A3,SHMT1,SKIL,THBS1,VCAN | NA |
| GH1 | NA | growth factor | NA | 6.70e-01 | 1.0e-02 | ADRB3,ATF4,CISH,GADD45A,GRIN1,HDAC1,ID3,IGFALS,JUN,JUP,MLH1,RAD23B,S100G,SATB1,SOCS1,SOCS2,SREBF1,TRPV1,XRCC6 | 722 (22) |
| MYCN | 1.00e+00 | transcription regulator | NA | 6.70e-01 | 2.0e-02 | ABCB10,ABCC4,ABCD1,ABCD4,ACTG1,ACTN4,ADAMTS1,APBB1,CAV1,CCND1,CDKN1A,COL18A1,EIF3C,EIF4A1,EIF5A,EPHA5,EZH2,FBXO32,FBXO36,FRMD6,HDAC11,HDAC5,HK2,HMGA1,ITGA2,JARID2,KDM5B,MYCN,NCL,NDRG1,PDIA4,PROM1,PTPRO,RPL9,SERPINE1,SLC16A1,SORD,TGM2,TH,TMEM109 | NA |
| CSF3 | 2.20e-01 | cytokine | NA | 6.60e-01 | 1.0e-02 | APBB1,ARHGEF10,CCL5,CCNE1,CD300LF,CISH,EGR2,EGR3,FARP1,FLOT1,GADD45A,GADD45B,GJA1,GRIN1,HOXB7,ICAM1,JUN,NECAB2,NFATC1,NFIL3,PLSCR1,PRKCB,Prrt1,SHANK2,SOCS1,STAT3,TFRC,TIAM1,TLR2,TLR5,TNFSF10 | 731 (17) |
| HBP1 | 2.40e-01 | transcription regulator | NA | 6.60e-01 | 1.0e-02 | CCL24,CCND1,CDKN1A,EZH2,MYCN | NA |
| lactacystin | NA | chemical - protease inhibitor | NA | 6.60e-01 | 0.0e+00 | AKR1B1,ASNS,BAD,BCAR1,CCND1,CCRL2,CDKN1A,CPOX,DUSP1,EIF4E,EIF5A,ESR1,FANCC,FOSL1,FTL,GJA1,HSPA5,HSPB8,IRAK4,KCNH2,MYCN,NCOA2,NCS1,NEDD9,NFKBIB,NOS1,NR1H3,RAD51,SFTPB,SLC3A2,SREBF1,TCERG1,TLR2,TUBB2A,TXNRD1,VDR | 743 (20) |
| nicotine | NA | chemical drug | NA | 6.60e-01 | 1.0e-02 | ACE,CABP1,CCND1,CD86,CDKN1A,CHGB,FGF9,GCH1,GHRL,GJA1,GJA4,HCRTR1,HCRTR2,ICAM1,LEP,MYCN,OGG1,PCNA,PENK,PLAT,PLCH1,RBBP6,SCNN1A,SERPINE1,SREBF1,STAT1,STAT3,TGM1,TH,VEGFC,WNT5A | NA |
| L-alanine | NA | chemical - endogenous mammalian | NA | 6.60e-01 | 0.0e+00 | CCND1,CCNE1,CDKN1A,PCNA | NA |
| L-aspartic acid | NA | chemical - endogenous mammalian | NA | 6.60e-01 | 0.0e+00 | CCND1,CCNE1,CDKN1A,PCNA | NA |
| L-asparagine | NA | chemical - endogenous mammalian | NA | 6.60e-01 | 0.0e+00 | CCND1,CCNE1,CDKN1A,PCNA | 599 (10) |
| L-proline | NA | chemical - endogenous mammalian | NA | 6.60e-01 | 0.0e+00 | CCND1,CCNE1,CDKN1A,PCNA | 252 (7) |
| SHC1 | 0.00e+00 | other | NA | 6.60e-01 | 4.0e-02 | BCL2L11,CDKN1A,CXCL10,FTL,ICAM1,LILRB4,MAP2K3,NQO1,PCNA,SERPINE1,THBD | NA |
| HDAC4 | -7.00e-01 | transcription regulator | NA | 6.50e-01 | 0.0e+00 | ANGPTL4,CAMTA2,CCND1,CDKN1A,DLG2,DRP2,EGR2,FGF13,FOSL1,GADD45A,GPHN,HDAC1,HDAC4,HDAC5,JUN,KLHL2,LDB2,MMD2,MYOM2,NR4A2,PRKCB,RGS7,SERPINB2,TRPV1 | 466 (9) |
| PSMD10 | -3.40e-01 | transcription regulator | NA | 6.50e-01 | 3.0e-02 | CCND1,CDKN1A,ICAM1,ME2,MRAS,MTHFD2,PCNA | NA |
| salirasib | NA | chemical drug | NA | 6.40e-01 | 1.0e-02 | ATF4,BHLHE40,CA9,HDAC1,NCL,P4HA1,PLAT,SERPINE1,TGM2,VEGFC | NA |
| BDNF | 3.40e-01 | growth factor | NA | 6.40e-01 | 0.0e+00 | ARPP21,ATP2A2,BCL2L11,BHLHE40,BMP7,CAV2,CDKN1A,CNR1,DUSP1,EGR2,EGR3,FRMD6,FSCN1,FTL,GPC4,GRB14,GRIN1,GRIN2C,HSPA2,HSPA5,INHBB,JUN,KIF5A,KLF4,LEP,mir-154,MYCN,NMB,NOS1,NR4A3,P4HA1,PCNA,PDE1A,PDLIM5,PENK,PTBP1,SCARB1,SEMA3E,SERPINH1,SLC12A5,TFRC,TGFB2,TH,THBS1,TIAM1,Ubb,VGF | 808 (25) |
| Sn50 peptide | NA | chemical toxicant | NA | 6.40e-01 | 2.0e-02 | BIRC2,Casp12,CXCL10,CYP27B1,GJA1,ICAM1,LIPG,OPRD1,SERPINE1,TNFRSF21,TNFSF10 | NA |
| L-glutamic acid | NA | chemical - endogenous mammalian | NA | 6.40e-01 | 3.0e-02 | BCL2L11,CCND1,CCNE1,CDKN1A,CIDEC,CLDND1,FADS1,FDFT1,GADD45B,GRIN1,HMGCS1,IL18,JUN,LEP,MAP2,NFIL3,NOS1,PCNA,Scd2 | NA |
| RBPJ | 4.80e-01 | transcription regulator | NA | 6.40e-01 | 0.0e+00 | AXIN2,BMP7,CDKN1A,CTRB2,DLL1,DUSP1,ECT2,EZH2,F11R,FDFT1,FGF11,FGF13,FGF7,FGF9,HMMR,HSD17B7,IL18,INHA,INHBB,JUN,MAP2K3,NFATC1,PDGFB,PLSCR1,REN,SDC1,TGFB2,TNC,VEGFC,WNT5A | 695 (23) |
| mibolerone | NA | chemical drug | NA | 6.30e-01 | 1.0e-02 | AMD1,AQP5,ARF4,CCDC116,CCND1,CEACAM1,DHRS3,EIF4A1,GMNN,HMGCS1,HSPA5,IRF7,JUN,LSS,PCNA,Scd2,TIMP3,TK1,UCP2,UCP3,USP18 | NA |
| SIX2 | 4.50e-01 | transcription regulator | NA | 6.30e-01 | 4.0e-02 | ANAPC1,CDC25A,CDKN1A,CDKN1C,CHGB,DUSP14,GREM1,MCM4,NUSAP1,PTPRN | NA |
| carbon tetrachloride | NA | chemical toxicant | NA | 6.30e-01 | 3.0e-02 | ABCC4,BCL2L11,CCL5,CD86,CDKN1A,CNR1,CXCL10,DUSP1,GADD45A,GADD45B,GBP5,GFER,ICAM1,JUN,Mt1,NQO1,NR0B2,NR1H4,PCNA,PDGFB,PDGFC,PDGFD,PROM1,PTP4A1,SERPINB2,SKIL,Slco1a4,SORD,TGFB2,TIMP3 | NA |
| RRAS2 | 4.00e-02 | enzyme | NA | 6.30e-01 | 0.0e+00 | CAV1,EGR3,FOSL1,FSCN1,IER3,IFI44L,IL18,ITGA5,ITGAV,LAMC2,NR4A3,PDGFC,PLSCR1,PROCR,RTP4,SEMA3E,SERPINE1,SGMS2,TRIM21,USP18,VCAN,VCL,VEGFC | 370 (7) |
| PNPLA8 | 1.70e-01 | enzyme | NA | 6.20e-01 | 0.0e+00 | DGAT1,FBXO32,HSPA5,Mt1,NQO1 | 622 (16) |
| SETD2 | 1.80e-01 | enzyme | NA | 6.20e-01 | 3.0e-02 | AXIN2,CAV1,CCND1,GJA4,JUN,PDGFC,SERPINE1,WNT5A | NA |
| 4-hydroxytamoxifen | NA | chemical drug | NA | 6.10e-01 | 1.0e-02 | AQP3,BCL2L11,BHLHE40,CCND1,CD55,CDKN1A,CLDN4,DUSP1,DUSP5,DUSP9,EIF5A,EPOR,ESR1,GLRX,HSD17B7,IER3,JUN,MICOS10-NBL1/NBL1,NEDD9,NR4A2,PDLIM3,RAI2,RIOX2,RND1,UNC119,VDR | 745 (20) |
| TBK1 | -4.60e-01 | kinase | NA | 6.00e-01 | 0.0e+00 | ATM,CCL5,CD86,CDKN1A,CXCL10,CXCL11,H2-T24,ICAM1,IFI16,IFI44,IFIH1,IL15RA,IL18,IRF7,ISG20,Oas1b,OAS2,Oasl2,PLA1A,SLFN13,SLFN5,TLR2,TLR3,TSC22D1,USP18 | 551 (15) |
| BRD4 | NA | kinase | NA | 6.00e-01 | 0.0e+00 | ABCC4,ABLIM1,AMPD1,ANKRA2,BCL3,BHLHE40,CCND1,CDC25A,CDCP1,CDKN1A,DCPS,ETV6,FADS1,GADD45A,HS1BP3,ICAM1,IRF1,ITGA5,JARID2,LOX,MANEAL,MCM3,MTHFD1L,MYCN,NQO1,PDGFB,PDGFC,PLAT,POLE2,RAI14,RRM2,RRS1,SFXN4,SORD,STC2,THBS1,WNT5A | 656 (21) |
| DDIT3 | 5.30e-01 | transcription regulator | NA | 6.00e-01 | 0.0e+00 | AGER,ASNS,ATF4,BCL2L11,DNAJA1,H6PD,HDAC1,HSPA5,IRAK2,ITGA2,LOX,MLF1,MTHFD2,NDRG1,NFIL3,PCNA,PLAT,SKP2,STAT3,TGFB2,TGM2,TNFRSF10A | 760 (19) |
| MDL 73811 | NA | chemical reagent | NA | 6.00e-01 | 3.0e-02 | CDKN1A,MAD2L1,PLK1,SERPINE1,TGM2 | NA |
| Map3k7 | NA | kinase | NA | 6.00e-01 | 1.0e-02 | BHLHE40,CCL5,CXCL10,EGR2,GAS1,ID4,IL15RA,ISG20,JUN,OSR1,PROM1,TLR3,TSC22D1 | 612 (16) |
| Smad | NA | complex | NA | 5.90e-01 | 2.0e-02 | ANGPTL4,CDKN1A,ID3,ID4,SERPINE1,WNT5A | NA |
| IL12B | -3.00e-02 | cytokine | NA | 5.90e-01 | 0.0e+00 | CCL5,CD86,CXCL10,DUSP5,ICAM1,IL12RB1,IRF9,PIK3AP1,SOCS1,STAT1,STAT2,STAT3 | 591 (16) |
| phytohemagglutinin | NA | chemical drug | NA | 5.80e-01 | 1.0e-02 | AGT,APOC2,ARR3,ARSB,BCL3,CCL5,CD83,CLCN4,COL18A1,CPM,CXCL10,DHX34,EIF5A,EPRS1,FGR,GJA4,GNAT1,ICAM1,IL15RA,IL1R2,JAK2,MCM4,NOP56,NT5E,OPRD1,PCNA,PDE1B,PLK1,PRKX,PTPN1,RAD52,RPA1,STAT1,STAT3,TIMP3,TMPO,TNFSF10,TRAF1 | NA |
| gefitinib | NA | chemical drug | NA | 5.80e-01 | 0.0e+00 | ADAMTS1,ADAMTS15,AURKA,BCL2L11,CCND1,CCNE1,CCNF,CHEK2,ECT2,EGR3,EHD1,EPSTI1,EZH2,FOSL1,FSCN1,GADD45B,GJA1,HYAL3,ID4,IL1R2,ITGA2,MAFF,MCM3,MMP15,Muc1,MYCN,OSMR,PCDH12,PCNA,PPP2R2B,PRC1,SKP2,SMC2,STAT1,TGM2,TIMP3,TLR2,TNFSF10,TRAF1,TSPAN8,WNT5B | 702 (20) |
| ZFTA-RELA | NA | fusion gene/product | NA | 5.80e-01 | 0.0e+00 | BCL3,CX3CL1,CXCL10,ICAM1,IL15RA,IRF1,IRF7,L1CAM,PDGFB,PRKCD,TGM2,TNIP1 | NA |
| NAE1 | -2.20e-01 | enzyme | NA | 5.80e-01 | 3.0e-02 | AURKA,CCND1,CDK5RAP1,CDKN1A | NA |
| progesterone | NA | chemical - endogenous mammalian | NA | 5.70e-01 | 0.0e+00 | ACE,ADAMTS1,AMD1,AURKA,BCAT1,BHLHA15,BHLHE40,CAPRIN2,CAV1,CCL5,CCND1,CCNE1,CD86,CDC25A,CDKN1A,CFTR,CIDEC,CLDN4,CNR1,Col17a1,CX3CL1,CXCL10,CXCL11,EPAS1,ESR1,F2R,FMO5,FOSL1,GAL,GCH1,GJA1,GNRHR,GPAM,GRB10,GREB1,GRIA3,HLA-G,HOPX,HSPA2,ICAM1,ID3,IDE,IL17RE,IL33,INHA,INMT,ISG20,ITGA11,ITGA2,ITGA5,JUN,KCNH2,LAMB3,LDLRAD4,LGR5,LRP2,MAD2L1,MAP2K3,MCM3,MCM4,Meis1,MICOS10-NBL1/NBL1,MPHOSPH10,Muc1,MX1,MYBL2,MYCN,MYO10,NDRG1,NEDD9,NET1,NFIL3,NR1D1,NR1H3,OXTR,PCNA,PLIN4,PLPP3,PRSS35,RRM2,S100G,Scd2,SCNN1B,SCNN1G,SFI1,SKP2,SOCS1,SRD5A1,SREBF1,SSTR1,STAT1,STAT3,TGFB2,TGFBR3,TGM1,TH,THBD,THBS1,TIAM1,TIMP3,TK1,TNFRSF21,TNFSF10,TRPV1,UGCG,VDR,WNT5B | 836 (20) |
| DCAF1 | 3.40e-01 | kinase | NA | 5.70e-01 | 1.0e-02 | BAD,CDKN1A,PLK1,PPIF,SOCS2,TGM2,TNFSF10 | 625 (10) |
| NPC1 | -4.10e-01 | transporter | NA | 5.60e-01 | 0.0e+00 | ATF4,ATG7,ATP6V1E1,BIN1,CAV1,CAV2,CCND1,CYP27B1,HMGCS1,ITGAX,KLF4,LIPG,LSS,MERTK,MMP15,OSBPL3,PLIN4,SRD5A1,SREBF1,STAT1,STAT2,STAT3,TMEM119,VPS16 | 651 (25) |
| MAF | -4.30e-01 | transcription regulator | NA | 5.60e-01 | 3.0e-02 | ANPEP,CRYAA/LOC102724652,CRYBA1,DEPTOR,FABP7,FDFT1,IL12RB1,LSS,MERTK,NQO1,NT5E | NA |
| OSMR | 6.70e-01 | transmembrane receptor | NA | 5.60e-01 | 0.0e+00 | BCL3,CISH,CXCL10,DHX58,GBP4,GBP5,Ifi47,Igtp,Irgm1,ITGAX,JAK2,Oasl2,OSMR,SOCS1,SREBF1,STAT3 | 608 (18) |
| FUS-DDIT3 | NA | fusion gene/product | NA | 5.60e-01 | 1.0e-02 | ASNS,JAK2,LOX,SERPINB2,SERPINE1,SOCS2,STAT2,STAT3,TYK2 | NA |
| thapsigargin | NA | chemical toxicant | NA | 5.50e-01 | 0.0e+00 | Acan,ASNS,ATF4,ATP2A2,BIRC2,CA9,Casp12,CAV1,CCND1,CD83,CD86,CDKN1A,CHAC1,CLDN4,COL18A1,COL2A1,CREB3L1,CXCL10,DIO2,ECD,EGR2,EIF1,EIF4E,ESR1,GADD45A,GADD45B,HSPA1A/HSPA1B,HSPA5,ICAM1,JUN,KLF4,LGR5,MLF1,NFIL3,NR0B2,NR4A3,OLR1,PAWR,PCNA,SDC1,SREBF1,TGM2,THBS1,TLR2,TNFSF10,TXNRD1,UBE2J1,UPP1,VCL | 680 (20) |
| sodium arsenite | NA | chemical drug | NA | 5.50e-01 | 0.0e+00 | AHCY,CCND1,CDKN1A,CISH,EGR3,EPAS1,ESR1,GADD45A,GADD45B,GREB1,HK2,JUN,OLR1,SOCS1,TH,TNFSF10 | 792 (23) |
| clofibrate | NA | chemical drug | NA | 5.50e-01 | 4.0e-02 | ABCC4,APOC2,BMP7,CCND1,CEACAM1,GADD45A,Mt1,NQO1,NR1H3,PEX11A,RORA,SLCO2A1,SREBF1,UCP2 | NA |
| dexamethasone | NA | chemical drug | NA | 5.50e-01 | 0.0e+00 | ABCC8,ACE,ACKR3,ACSL3,ACTG1,ADAM10,ADAMTS1,ADAMTS15,ADRB3,AGT,Akr1b7,ANGPT1,ANGPTL4,ANPEP,AQP5,ASCL2,ASNS,ASPH,ATF4,ATOH8,ATP2A2,AXIN2,BAD,BCAR1,BCL2L11,BCL3,BDKRB2,BHLHE40,BIRC2,BZW2,CARS1,CAV1,CAV2,CCL5,CCND1,CCNE1,CD55,CD83,CD86,CDC25A,CDC42EP3,CDKN1A,CDKN1C,CDV3,CEACAM1,CEP135,CEP70,CIDEC,CISH,CLDN18,CLEC4D,CLEC7A,CLIC4,COL11A2,COQ8B,CPSF3,CRISPLD2,CRYAA/LOC102724652,CSF2RB,CTF1,CTRB2,CX3CL1,CXCL10,CXCR3,CYP27B1,Cyp3a25 (includes others),DGKG,DIO2,DLL1,DPH5,DUSP1,DUSP5,E2F4,ECT2,EDARADD,EGR2,EGR3,EIF4E,EIF6,ELN,EMILIN2,EPAS1,EPSTI1,EXT1,FAM107A,FANCG,FBN2,FBXO32,FDX1,FGF7,FMO1,FOSL1,FTL,GADD45A,GADD45B,GAL,GAS1,GBP1,GBP5,GEM,GFOD1,GFOD2,GHRL,GJA1,GLP1R,GNRHR,GPR83,GRAMD4,GTF2IRD1,H6PD,HDAC1,HELZ2,HHIP,HK2,HLTF,HMGA1,HMMR,HSD17B7,HSPA5,HSPH1,ICAM1,IDE,IDH1,IER3,IFI35,IFI44,IGFALS,IL12RB1,IL18,IL1R2,IL33,ILVBL,INHBB,IRAK4,IRF1,IRF2BP2,IRF7,IRF9,ISG20,ITGA2,ITGA5,ITGAV,ITPKC,JAK2,JARID2,JUN,KCNH2,KCNJ1,KLF4,KNL1,LAMA5,LAMB3,LEF1,LEP,LGALS12,LILRB4,LOX,LSR,LSS,MAFF,MAP2,MAP3K5,MATN4,MBD2,MCM4,MEGF9,MERTK,MID1IP1,MMP19,Mt1,MTHFD1,MX1,MYCN,MYO10,NAGK,NAV3,NET1,NFATC1,NFIL3,NLRP3,NMB,NOS1,NQO1,NR1H3,NR4A3,NYX,OLFML2B,OLR1,OXTR,P2RY14,P4HA1,PAH,PARP14,PCNA,PCSK6,PDE4B,PDE4D,PDK2,PENK,PEX11G,PHTF2,PKP2,PLAT,PNLIPRP2,PNPLA2,POLE2,POR,PRKCB,PTGDR2,PTGFRN,RAB11FIP3,RAD51,RAPGEF4,RASL11B,RBL2,RET,RFX2,RGS10,RNF128,RNF43,RORA,RTP4,S100G,SCARB1,Scd2,SCG3,SCNN1A,SCNN1B,SCNN1G,SEC61A1,SERPINB2,SERPINE1,SFTPB,SHMT1,SLC13A3,SLC14A1,SLC26A6,SLC2A5,SLC39A10,SLC45A3,SLC5A1,SLC6A4,SLC7A7,SLC9A3,Slco1a4,SLCO2A1,SMARCD2,SOCS1,SOCS2,SORD,SPON2,SPR,SREBF1,ST3GAL5,STAT1,STAT2,Sult1d1,TAF6,TFAP4,TFRC,TGFB2,TGFBR3,TGIF2,TGM2,THBD,THBS1,TIMP3,TK1,TLE2,TLR2,TLR5,TMPRSS4,TNC,TNFRSF10A,TNFRSF21,TNFSF10,TPT1,TRAF1,TRERF1,TRIM63,TRPV1,TSC22D1,TWF2,UBE2C,UBE2G1,UCP2,UCP3,UGCG,UGT2A1,UNC13B,USP18,VCAN,VCL,VDR,VEGFC,WNT5A,ZNF467 | 872 (21) |
| INHBA | -5.60e-01 | growth factor | NA | 5.40e-01 | 0.0e+00 | AMMECR1,BAMBI,CCND1,CDC25A,CDKN1A,CLASP2,COIL,CPNE8,EFNB2,ESR1,FIGN,GNRHR,GRIA3,HLA-G,HNF1A,INHA,INHBB,IRF1,ITGA11,KLF4,LOX,MAD1L1,MPPED2,NAV3,NR4A2,NRG1,PCNA,PCSK6,PTBP2,SERPINB2,SERPINE1,SFTPC,SLC5A8,SOCS1,TPSAB1/TPSB2 | 918 (26) |
| TGFA | 4.90e-01 | growth factor | NA | 5.40e-01 | 2.0e-02 | CCL5,CCND1,CDKN1A,CXCL10,ESR1,FGF7,ICAM1,LAMC2,NR4A2,PLAT,SERPINE1,TLR5,WNT5A | NA |
| KDM1A | 1.80e-01 | enzyme | NA | 5.40e-01 | 0.0e+00 | AGT,ATAD2,BCL3,BLM,CCL5,Ccl6,CDKN1A,CLEC7A,CXCL10,Cxcl3,ELOVL7,EPSTI1,FGR,GALNT15,GBP4,GBP5,GREB1,HOXB7,HSPB8,IFI16,IFI44,Igtp,IRF7,Irgm1,ITGAX,LCP1,LGR5,MAP2,MCM3,MCM4,MYBL2,NCL,NEK3,Oasl2,OSMR,PARP14,PLIN4,PROM1,RNF213,SERPINE1,SLFN13,SOCS2,SREBF1,STEAP3,TGM1,THBS1,TLR2,TMCO4,TOX2,TRIM21,TRIM37,UCP2,USP18,VCL | 660 (23) |
| ATP | NA | chemical - endogenous mammalian | NA | 5.40e-01 | 1.0e-02 | BCL2L11,CCND1,CD200,CD83,CD86,CXCL10,DUSP1,GSDMD,ICAM1,IL18,IL33,NFATC1,NLRP3,NOS1,PLD2,REN,SERPINE1,SREBF1,THBS1,TRPV1 | 749 (19) |
| AGN194204 | NA | chemical drug | NA | 5.40e-01 | 0.0e+00 | ACAT2,Akr1b7,ANGPTL4,ANXA11,AURKA,BZW2,CDKN1A,CLIC4,DOCK8,DUSP1,ELOVL5,ENO3,EZH2,FDFT1,FDX1,GADD45A,GJA1,GPRC5A,HK2,Ifi47,Igtp,IL12RB1,IL1R2,IL33,IRF1,KRT80,LILRB4,LSS,MAD2L1,PDE1B,PENK,PLIN4,PLK1,PRC1,RGS10,Scd2,SEMA4B,SLC3A2,SMC2,SNTB1,SYT13 | NA |
| paclitaxel | NA | chemical drug | NA | 5.30e-01 | 0.0e+00 | ABCB10,ACKR3,ALPK3,ANGPT1,APLNR,ATF4,AURKA,BCL2L11,BHLHE40,CAV1,CCND1,CD86,CDC42EP3,CDK18,CDKN1A,CRY2,CXCL10,DEPDC5,DUSP5,ETV1,FOSL1,GADD45B,GRAMD1B,ICAM1,IER3,IRAK4,ITGA5,ITPKC,JUN,KDSR,KIFC3,KLF4,LCP1,LILRB4,NAV3,NCS1,NFATC1,NT5E,OSMR,PCNA,PLIN3,PPP2R3A,RBM3,REN,SERPINB2,SFI1,STAT3,THBD,THBS1,TNFRSF10A,TRAF1,TSC22D1,UGCG,VASH1,YBX1 | 778 (22) |
| mir-182 | NA | microRNA | NA | 5.20e-01 | 4.0e-02 | CARD11,CCL24,CD200R1,CLDN15,CLEC10A,CLEC7A,COL11A2,DGAT1,JUP,KLF4,SLC30A1,SLC39A7 | NA |
| CSF2 | NA | cytokine | NA | 5.10e-01 | 0.0e+00 | ACE,ATM,ATXN1,AURKA,BAD,BCL2L11,BCL3,CARD11,CCND1,CCNF,CCRL2,CD83,CD86,CDKN1A,CEACAM1,CHTF18,CISH,CLEC7A,CSF2RB,CSNK2A2,CXCL10,Cxcl3,CXCR3,DNAJC5,DSCC1,EGR2,EGR3,ELN,EPOR,ERCC6L,F2R,FOSL1,GCH1,GHRL,HK2,HSPH1,ICAM1,ID3,IER3,IL19,ITGAX,JAK2,JUN,LCP1,LEP,MCM3,MLH1,NDST1,NET1,NFATC1,NLRP3,NR1H3,NR4A2,NR4A3,NUAK2,NUSAP1,OLR1,OSMR,PDE1B,PDE4B,PIM3,PLK1,PNPLA1,POLD1,PPIF,PRC1,RAD51,RBBP9,RBM3,REC8,RRM2,SLC7A11,SMC2,SNTB1,SOCS1,SOCS2,SREBF1,STEAP3,TGM2,THBS1,TLR2,TLR5,TPT1,UBE2C,UPP1,VDR | 800 (18) |
| homocysteine | NA | chemical - endogenous mammalian | NA | 5.10e-01 | 1.0e-02 | ASNS,ATF4,CCL5,CCND1,CDKN1A,CXCL10,ELOVL5,FADS1,GADD45A,HSPA5,LEP,LTA4H,NDRG1,NPHS2,OLR1,OXTR,SREBF1 | NA |
| Fc gamma receptor | NA | group | NA | 5.10e-01 | 5.0e-02 | CCND1,CCNE1,CD86,CDKN1A,ICAM1,NOS1 | NA |
| GPER1 | 2.00e-01 | G-protein coupled receptor | NA | 5.10e-01 | 2.0e-02 | BHLHE40,CCND1,CDKN1A,DUSP1,DUSP5,ESR1,HSPA5,JUN,NOP58,NR4A2,RND1 | NA |
| mir-142 | NA | microRNA | NA | 5.10e-01 | 2.0e-02 | GBP4,GBP5,INPP4B,IRF1,ITGAV,ITGAX,PROM1,PTPN1,SOCS1,STAT1,TNFSF10,TSC22D1 | NA |
| ionomycin | NA | chemical reagent | NA | 5.00e-01 | 1.0e-02 | ATP2A2,CIDEC,CLDN4,CXCL10,DUSP1,DUSP5,EIF4E,ERFE,GBP4,GCH1,GEM,HK2,HSPA5,ICAM1,JARID2,KCNJ2,LAT,NCL,NFATC1,NFIL3,NR4A2,PTPN1,SLC3A2,SOCS2,STAT3,TLE4,TLR2,TNFSF10 | 721 (19) |
| EIF4EBP1 | -3.40e-01 | translation regulator | NA | 5.00e-01 | 1.0e-02 | ATF4,CCL5,CCND1,CXCL10,HK2,IRF7,LEP,NFIL3,PNPLA2,SERPINB2,SOCS1 | NA |
| prexasertib | NA | chemical drug | NA | 5.00e-01 | 0.0e+00 | BCL3,CDKN1A,DUSP1,EGR3,GADD45B,GHRL,ICAM1,IER3,IFIH1,IRF7,KLF4,NR4A3,PCNA,SERPINE1,SIRT4,SKIL,TRAF1 | 658 (18) |
| RARB | 1.00e-02 | ligand-dependent nuclear receptor | NA | 5.00e-01 | 0.0e+00 | ADAM10,BIRC2,CCNE1,CDKN1A,DHRS3,ENOX1,GADD45A,GSDMC,HOXB7,ICAM1,ID3,Ifi47,Igtp,Irgm1,ITGAV,JUN,KLF4,MAP2K3,Meis1,RET,SATB1,STAT1,TGM1,THBD,USP18,VEGFC,ZNF703 | 701 (22) |
| chenodeoxycholic acid | NA | chemical - endogenous mammalian | NA | 5.00e-01 | 0.0e+00 | AGT,APOC2,ATF4,CAV1,CRYAA/LOC102724652,HK2,HNF1A,LIPC,LRP2,NR0B2,NR1H4,SDC1,SLC5A8,TK1,TRPV1,TXNRD1,VDR | 634 (10) |
| TSC2 | -5.00e-02 | other | NA | 4.90e-01 | 5.0e-02 | ASCL2,ATF4,AXIN2,BCL3,CCND1,CDKN1A,CXCL10,EGR2,FAM107A,HK2,HSPA5,IFI44,Ifi47,JAK2,LGR5,Mt1,OGG1,PPP1R3B,SLC14A1,STAT1,UCP2 | NA |
| dalfampridine | NA | chemical drug | NA | 4.90e-01 | 3.0e-02 | DUSP1,EGR2,GADD45B,HK2,JUN,KCNA5,KLF4,MAFF,mir-154,NR4A2 | NA |
| COL18A1 | 6.30e-01 | other | NA | 4.90e-01 | 1.0e-02 | BAD,CCND1,EFNB2,F2R,HK2,ICAM1,ID3,IL18,ITGAV,JUN,SERPINE1,STAT1,STAT3,THBS1,TNFRSF21 | 620 (20) |
| FBXW7 | 3.80e-01 | enzyme | NA | 4.90e-01 | 0.0e+00 | BCL2L11,CARD11,CIDEC,CREB3L1,DDX11,DGAT1,DNAJA1,FDFT1,GPAM,HSPH1,IDH1,JUN,ME2,MTHFD2,NQO1,SERPINE1,SREBF1,STAT2 | 525 (8) |
| diethylstilbestrol | NA | chemical drug | NA | 4.90e-01 | 0.0e+00 | AQP3,BCAT1,CCND1,CD200,CD55,CD83,CDKN1A,COMP,ESR1,FMO1,GADD45A,GAL,GLRX,GREB1,GREM1,IL1R2,INHA,INHBB,JAK2,KLF4,Ldha/RGD1562690,LEP,MAD2L1,Muc1,NR4A3,NUMBL,OXTR,PAIP2B,PCNA,PDGFB,PROM1,REN,RNF4,S100G,SERPINB2,SLC6A14,Slco1a4,SOCS2,STEAP3,Tlr12,VDR,WNT5A | 753 (18) |
| MAP2K1/2 | NA | group | NA | 4.90e-01 | 3.0e-02 | BCL2L11,CCND1,DUSP1,EGR2,ELN,FOSL1,GJA1,HK2,HSPA5,JUN,PCNA,SCARB1 | NA |
| estradiol benzoate | NA | chemical drug | NA | 4.80e-01 | 4.0e-02 | ESR1,GJA1,GNRHR,GRIN1,HCRTR1,NQO1,OXTR,PAQR8,PENK,PLAT,UCP2,UCP3 | NA |
| MAPT | 9.00e-02 | other | NA | 4.80e-01 | 0.0e+00 | ACTG1,ANGPT1,Arf2,ARF4,ARF6,ATP4A,ATP6V1E1,BCL3,CALML3,Ccl6,CCND1,CDKN1A,CKB,CLASP2,CLEC7A,CXCL10,Cxcl3,DMXL2,DNAJC5,ELOVL7,EPRS1,EPSTI1,ERMP1,FGR,Fus,GALNT15,GBP4,GBP5,GEM,GMPS,GNAZ,GRIN1,HSPA1A/HSPA1B,HSPA5,HSPB8,HSPH1,ICAM1,IFI16,IFI44,Igtp,IRF7,Irgm1,ITGA5,ITGAX,JUN,LCP1,MAP2,MAP6,MTHFD1,MTHFD1L,NDUFA5,NOS1,NQO1,Oasl2,OSMR,PAK1,PARP14,PENK,PLIN4,RNF213,SERPINE1,SLC14A1,SLFN13,TGM1,TH,THBS1,TLR2,TMCO4,TPT1,TRIM21,TUBA1C,TUBB2A,TUBB4B,TUBB6,UCP2,USP18,WDR7 | 725 (17) |
| atorvastatin | NA | chemical drug | NA | 4.80e-01 | 1.0e-02 | AGER,CAV1,CCBE1,CD55,CDKN2AIPNL,DUSP1,F2R,FDFT1,GADD45B,GJA1,GPAM,HHIP,HMGCS1,HSD17B7,ICAM1,IER3,JUN,LEP,LIPG,LSS,MAP1LC3A,NOS1,NR0B2,NR1H3,OLR1,PLAT,SERPINE1,TLR2,TMEM106A,TMEM267 | NA |
| tofacitinib | NA | chemical drug | NA | 4.80e-01 | 0.0e+00 | CCND1,CISH,CXCL10,HK2,SOCS1,SOCS2,STAT3 | 696 (19) |
| MAP3K12 | -5.00e-02 | kinase | NA | 4.80e-01 | 3.0e-02 | ACTG1,JUN,RPS18,STAT3,TUBB2A,TUBB4B | NA |
| CGA | -1.40e-01 | other | NA | 4.80e-01 | 1.0e-02 | ADAMTS1,BHLHA15,BIRC2,CCND1,CREB3L1,EDEM2,EGR2,GTF2F2,HSPA5,IRAK2,PDIA4,SCX,SERP2,SKP2,SPOP,TIMP3,ZNF385B | 299 (7) |
| MRTFB | NA | transcription regulator | NA | 4.70e-01 | 0.0e+00 | ABLIM1,ACTG1,ADAMTS1,CCL5,CDC42EP3,CLDN15,EGR2,EGR3,ETV6,F11R,F2R,FJX1,GADD45A,GAS1,ITGA5,KAZN,LILRB4,MAFK,MAP2,Prss34,PTPRO,SCARB1,SERPINB2,SERPINE1,SLC6A4,SLFN5,TGFB2,THBS1,Tpm4,VCL,WNT5A | 277 (7) |
| 17-alpha-ethinylestradiol | NA | chemical drug | NA | 4.70e-01 | 0.0e+00 | APOC2,AQP3,ASNS,ATF4,BCAT1,BCL3,CCL5,CDKN1A,CKB,CXCL10,CXCR3,FABP7,IFI16,INHBB,JUN,NR0B2,NR1H4,PCNA,SCARB1,SERPINH1,Slco1a4,SNAPC2,SOCS1,TGM2 | 828 (21) |
| Srgn | 1.00e-01 | other | NA | 4.70e-01 | 2.0e-02 | BANP,CD300LF,CD83,EGR3,Irgm1,ITGAX,LY6D,THBS1,TPSAB1/TPSB2 | NA |
| PTK2 | -1.60e-01 | kinase | NA | 4.70e-01 | 2.0e-02 | BIRC2,CCND1,CDKN1A,DSP,ITGA5,mir-154,P4HA1,SKP2,THBS1,TIMP3,TNC | NA |
| dextran sulfate | NA | chemical drug | NA | 4.70e-01 | 0.0e+00 | ACE,ADAMTS1,AGT,ATM,AURKA,BLM,CARD11,CCL5,CCND1,CCNF,CD83,CD86,CDKN1A,CHTF18,COL18A1,CXCL10,DCLRE1A,DSCC1,EFNB2,ERCC6L,ICAM1,ID3,IL18,IRF7,LCP1,MCM3,MLH1,MSH2,MSH3,NDST1,NLRP3,NQO1,NUSAP1,OSMR,PARP1,PARP2,PCNA,PDGFB,PLK1,POLD1,PRC1,RAD51,RBBP9,REC8,REN,RRM2,SDC1,SERPINB2,SERPINE1,SMC2,SOX12,SPON2,STAT3,STEAP3,TGFB2,TGFBR3,TGM2,THBS1,UBE2C,VDR,VEGFC,WNT5A,WNT5B | 679 (19) |
| YAP1 | NA | transcription regulator | NA | 4.60e-01 | 0.0e+00 | ACAT2,ACTG1,ADAMTS1,AMPD1,ARHGEF6,ASCL2,ATAD2,B4GALT7,BCL2L11,BIN1,CCL5,CCND1,CCNF,CCRL2,CDC42EP3,CDK5RAP1,CDKN1A,CDKN1C,CEP131,CIT,E2F4,EGR2,EHD1,ESR1,F11R,FBXO32,GADD45A,GREB1,GREM1,HMGCS1,ICAM1,IFI35,ISG20,ITGA5,KCNH2,LGR5,LOX,MCM3,MPDZ,NDRG1,NF2,NIPAL3,NPEPPS,NRIP3,NUAK2,OXNAD1,P4HA1,PDE3B,PDGFB,PLK1,PMEPA1,POLA1,PPP1R3B,PRKDC,PTGFR,PTPN1,RAD51,RPL3L,RPL9,RPS18,RRM2,SENP2,SERPINE1,SKP2,SMARCA2,SPOP,STAT1,TFRC,TGFB2,THBS1,TK1,TMEM177,TPRA1,TRADD,TRIM63,TTC8,UCP2,VCL | 657 (19) |
| epinephrine | NA | chemical - endogenous mammalian | NA | 4.60e-01 | 0.0e+00 | AQP3,CCND1,CCNE1,CDKN1A,ERFE,HK2,IL33,LEP,PCNA,PENK,POLA1,PRIM2,Slco1a4,TFRC,TLR5,TRIM63 | 687 (22) |
| NCOA5 | 2.80e-01 | other | NA | 4.50e-01 | 1.0e-02 | ANGPTL4,ATF7IP,Atp8b5,CDKN1A,CIDEC,EDA2R,KLHDC1,MTHFD1,PHLDA3,ZFYVE19 | NA |
| PTH | NA | other | NA | 4.50e-01 | 0.0e+00 | Acan,ADAMTS1,ANGPT1,ATP2A2,BHLHE40,CCND1,CDKN1A,CGNL1,COL2A1,CYP27B1,DUSP1,EFNB2,EGR2,GALNT3,GJA1,HDAC4,HSPA5,ID4,IL33,ITGAV,JUN,LEF1,NFIL3,NR4A2,PALM,S100G,SLC9A3,TMEM119,VDR | 679 (21) |
| curcumin | NA | chemical drug | NA | 4.50e-01 | 0.0e+00 | ADAMTS4,BANP,BCL2L11,BIRC2,CAV1,CCL5,CCND1,CCNE1,CD86,CDKN1A,CLDN4,CRY2,CXCR3,DNAJB1,E2F4,EIF4E,EZH2,FOSL1,FTL,HDAC1,HDAC8,HSPA1A/HSPA1B,ICAM1,IL10RB,JUN,LEP,MAP2,MARCKSL1,MLH1,MTHFD1,NQO1,OGG1,OLR1,PAK1,PDE3B,PIGF,PNPLA2,SCARB1,SERPINE1,SOCS1,SREBF1,STAT3,STXBP3,TFRC,TIMP3,TLR2,TNFRSF10A,TPT1,TRAF1,UCP2 | 763 (21) |
| DEPTOR | -1.05e+00 | other | NA | 4.50e-01 | 0.0e+00 | CCL5,CX3CL1,CXCL10,CXCL11,ICAM1 | 442 (12) |
| CHRM1 | -1.24e+00 | G-protein coupled receptor | NA | 4.50e-01 | 0.0e+00 | CHRM1,EGR2,EGR3,JUN,NOS1 | 731 (24) |
| E2F6 | -1.00e-01 | transcription regulator | NA | 4.50e-01 | 1.0e-02 | CAMTA2,CCNE1,CDC25A,CHEK2,DDX11,GJA1,GMNN,MCM3,RAD51,RRM2,SERPINE1,ZNF43 | 434 (12) |
| HGS | 4.20e-01 | other | NA | 4.50e-01 | 2.0e-02 | EGR2,ESR1,JUN,SCNN1A,SREBF1 | NA |
| HRG | NA | other | NA | 4.50e-01 | 2.0e-02 | CCL24,Ccl6,CD83,ITGAX,TIMP3 | NA |
| TEAD2 | -6.80e-01 | transcription regulator | NA | 4.50e-01 | 3.0e-02 | CCND1,CCNF,FJX1,KAZN,POLA1,PTPRO,RAD51,SLFN5,THBS1 | NA |
| PDGF-DD | NA | complex | NA | 4.50e-01 | 4.0e-02 | Casp12,EGR3,PDE1B,TUBB6,UNC5C | NA |
| N-nitro-L-arginine methyl ester | NA | chemical drug | NA | 4.40e-01 | 5.0e-02 | ACE,AGT,CD83,CD86,GJA1,ICAM1,ITGAV,NOS1,OLR1,REN,SERPINE1,SREBF1,TLR2,UCP3 | NA |
| GABPA | 1.00e-01 | transcription regulator | NA | 4.40e-01 | 3.0e-02 | ATM,AURKA,IL18,NQO1,OXTR,PRKDC,SKP2,SLC7A11,TNC,XRCC6 | NA |
| sertraline | NA | chemical drug | NA | 4.40e-01 | 3.0e-02 | AFMID,ATF4,PDE4A,PDE4B,SLC7A5 | NA |
| ZFP36 | -1.50e-01 | transcription regulator | NA | 4.40e-01 | 1.0e-02 | CDKN1A,CLCN3,FOSL1,ICAM1,IER3,IRF1,JUN,MEFV,PNRC1,PRC1,SOCS1,TFRC,THBD,TRAF1,VEGFC | NA |
| APOE | 3.00e-02 | transporter | NA | 4.30e-01 | 1.0e-02 | ADAM10,AGER,ANGPTL4,ANXA11,ATF4,CABP1,CAV1,CCL5,CCND1,CD86,COL18A1,CREB3L1,CSF2RB,ESR1,F2R,GRIA3,HMMR,HSPA1A/HSPA1B,HSPA5,ICAM1,IL10RB,ITGA5,ITGAX,JUN,KLF4,LEP,LIMS2,LIPG,LTBP1,MAP2,MAP2K3,NR1H3,PLPP3,PMEPA1,PRKCB,RTN4R,SCARB1,SERPINE1,SLC16A1,STAT1,STAT3,TIAM1,TLR2,TNIP1,UCP2,VCAN | 809 (24) |
| CDC42 | NA | enzyme | NA | 4.30e-01 | 0.0e+00 | BCL2L11,CCND1,CCNE1,CD86,COL2A1,ESR1,JUN,SCARB1,STAT3,TGM2,UBE2C | 781 (21) |
| PLIN5 | -7.90e-01 | other | NA | 4.30e-01 | 2.0e-02 | ATF4,MAFK,NQO1,PNPLA2,POR,SREBF1,TXNRD1,UCP3 | NA |
| AMH | 5.80e-01 | growth factor | NA | 4.30e-01 | 2.0e-02 | CDKN1A,CEACAM1,IER3,INHA,IRF1,RBL2 | NA |
| chromium | NA | chemical drug | NA | 4.30e-01 | 3.0e-02 | CDK2AP2,ERCC5,ESR1,METTL21A,NQO1,NUMBL,PPIF,TAF6,ZWINT | NA |
| NTRK3 | NA | kinase | NA | 4.20e-01 | 3.0e-02 | CDKN1A,EGR2,GRIN1,PMEPA1,PROM1,SERPINE1 | NA |
| valproic acid | NA | chemical drug | NA | 4.20e-01 | 0.0e+00 | AKR1B1,ATAD2,ATF4,ATM,AVPR2,BCL2L11,C8orf44-SGK3/SGK3,CCND1,CD83,CDKN1A,CDKN1C,CYP39A1,ESR1,ETV6,FAM107A,FAM135B,FDFT1,FRMD6,FSCN1,GADD45B,GPAM,GREB1,H6PD,HDAC5,HMGCS1,HNRNPA1,HSD3B7,HSPA5,ICAM1,ING1,JUN,LEP,LOXL3,LRAT,MAD1L1,MCM3,MYCN,MYOF,NARF,NFYA,NQO1,NR0B2,P3H2,PAK1,PAQR7,PDGFB,PLAT,PNPLA2,PPRC1,PRKCD,SERPINE1,SERPINH1,SIRT4,SREBF1,ST3GAL5,STAT3,TGM2,TH,THBS1,TMEM164,TMPO,TNFRSF10A,TNFSF10,WDR7,WNT5A | 885 (22) |
| POMC | 6.00e-02 | other | NA | 4.20e-01 | 2.0e-02 | Akr1b7,DUSP1,FOSL1,ICAM1,IL18,JUN,LEP,NCOA2,NOS1,NR4A2,NR4A3,PCNA,REN,SCARB1,TH | NA |
| ST3-Hel2A-2 | NA | chemical reagent | NA | 4.20e-01 | 0.0e+00 | CDKN1C,EGR2,GADD45A,IER3,NR4A2 | 501 (7) |
| aflatoxin B1 | NA | chemical - endogenous non-mammalian | NA | 4.20e-01 | 0.0e+00 | ACSL3,Akr1b10,CCNE1,CDKN1A,CFTR,CLIC5,CX3CL1,DDIT4L,DDR1,ECT2,EDA2R,ERMP1,FADS1,FAM83F,Gabpb1,GJA1,GRIA3,HLTF,HMMR,HTATIP2,ITGA5,KIFC3,KNL1,LAMA5,LAMC2,MAD2L1,MCM3,MTHFD1L,Muc1,MYBL2,NDRG1,NQO1,NRG1,NUSAP1,PAK1,PHLDA3,PLK1,PRC1,RAD51,S100G,SLC5A1,SLC7A11,SMC2,TRIM37,TRPV1,TSPAN8,TXNRD1,UBE2C,VDR,WFIKKN2,XRCC6 | NA |
| Pkc(s) | NA | group | NA | 4.20e-01 | 0.0e+00 | AQP3,BCL2L11,CD55,CDKN1A,DUSP1,EGR2,FOSL1,GADD45A,GADD45B,GNRHR,HSPA5,IRF6,ITGA5,JUN,KCNJ2,MAD1L1,MAFK,MAP3K5,NOS1,NQO1,NR1D1,NR4A2,NR4A3,PDIA4,PTPRN,RBL2,SCARB1,SERPINE1,SLC6A4,STC2,TGM1,TH,VDR | 731 (22) |
| STK11 | 1.70e-01 | kinase | NA | 4.20e-01 | 0.0e+00 | ACE,AHCY,BCL2L11,BCL6B,CAMKK1,CCND1,CDKN1A,CHGB,Cxcl3,DLGAP2,FOSL1,GADD45A,GADD45B,GRIA3,HDAC4,HHIP,IL33,MAFK,MED26,MRI1,NEDD9,NET1,NPTX2,NR1D1,NR4A2,NT5E,PIK3R4,POLR1C,PRIM2,PTPRN,RASSF1,REN,RPIA,RRM2,SERPINE1,TNFSF10,TWF2,TXNRD1,WNT5A,ZNF462 | 723 (23) |
| BCL2 | -2.10e-01 | transporter | NA | 4.20e-01 | 4.0e-02 | Acan,ATP2A2,BCL2L11,CCND1,CCNE1,CDKN1A,CHGB,CLCN3,COL2A1,GADD45A,ICAM1,NDRG1,RBL2,SCG3,TGFB2 | NA |
| CTNNBIP1 | 3.00e-02 | other | NA | 4.10e-01 | 0.0e+00 | AXIN2,CCND1,CDKN1A,HMGCS1,NEDD9 | 588 (13) |
| lysophosphatidic acid | NA | chemical - other | NA | 4.10e-01 | 2.0e-02 | CCL5,CCND1,CCNE1,CXCL10,DUSP1,ICAM1,JUN,LIPG,PPP1R3B,RFFL,SCARB1,SERPINE1,SOCS1,VEGFC,WNT5A | NA |
| MGAT5 | -3.90e-01 | enzyme | NA | 4.00e-01 | 4.0e-02 | ASCL2,AXIN2,ITGA5,LGR5,PROM1 | NA |
| 5-O-mycolyl-beta-araf-(1->2)-5-O-mycolyl-alpha-araf-(1->1’)-glycerol | NA | chemical - endogenous non-mammalian | NA | 3.90e-01 | 0.0e+00 | BCL3,CD83,CXCL10,CXCL11,DUSP1,EGR2,ICAM1,IER3,NLRC3,NR4A3,NT5E,PDE4B,SERPINB2,SLC7A11,TRAF1 | 452 (8) |
| HMG20A | -1.90e-01 | transcription regulator | NA | 3.90e-01 | 0.0e+00 | ACTG1,ATP2A2,CCL5,CX3CL1,CXCL10,ELN,FDFT1,GADD45A,GCH1,HMGCS1,HSD17B7,IL15RA,IRF7,ITGA2,ITGA5,JUN,LSS,NT5E,OSMR,RTP4,SERPINE1,TGM2,TIMP3,TLR3,VCAN,VEGFC | 500 (13) |
| sorbitol | NA | chemical - endogenous mammalian | NA | 3.90e-01 | 0.0e+00 | AKR1B1,AQP5,CDKN1A,GJA1,RGS7,SORD | 683 (21) |
| EIF2S1 | 3.70e-01 | translation regulator | NA | 3.90e-01 | 4.0e-02 | ATF4,CA9,CCND1,CCNE1,CHAC1,GADD45A,PLIN4,SLC7A11,TGM1 | NA |
| SMAD5 | 3.60e-01 | transcription regulator | NA | 3.90e-01 | 5.0e-02 | DIDO1,ICAM1,ID3,ID4,PDGFB,SERPINE1 | NA |
| NFKBIA | -1.70e-01 | transcription regulator | NA | 3.90e-01 | 0.0e+00 | ACKR3,ASCL2,ATP6V1B1,BCL3,BIRC2,CCL5,CCND1,CD86,CDC25A,CDKN1A,CFTR,COL2A1,CX3CL1,CXCL10,CXCL11,FSCN1,FZD7,GADD45A,GADD45B,GCH1,GRIN1,HAS1,HK2,HMGA1,HSPA5,ICAM1,ID3,IER3,IFI16,IL15RA,IL33,IRF1,ITGA2,ITGAV,JUN,KCNH2,LAMA5,LGR5,MMP15,MSH2,Mt1,NFKBIB,NOCT,OPRD1,PCNA,PLAT,PMEPA1,POLR1C,RABEP2,RGS3,RPS18,SDC1,SERPINB2,TFCP2L1,TFRC,TGFB2,TIMP3,TLR2,TMPO,TNC,TNFRSF10A,TNFSF10,TOLLIP,TRADD,TRAF1,Ubb,VEGFC,XRCC6 | 723 (17) |
| ATG5 | NA | other | NA | 3.90e-01 | 0.0e+00 | AGT,BCL2L11,CCL5,CLASP2,CLEC10A,EIF5A,EVA1A,HK2,HSPA5,ICAM1,IFIH1,NQO1,PPP2R2B,PRKCD,SCARB1,TGM2,WIPI2 | 691 (19) |
| BAPTA-AM | NA | chemical reagent | NA | 3.90e-01 | 1.0e-02 | AQP5,CDKN1A,CISH,CXCL10,CXCL11,HSPA5,ICAM1,JUN,NFATC1,SOCS1,SOCS2 | NA |
| alitretinoin | NA | chemical drug | NA | 3.80e-01 | 2.0e-02 | ADAM10,ADAMTS4,BMP7,Casp12,CCL24,Ccl6,CCND1,CD83,CD86,CDKN1A,CPM,CXCL10,CXCL11,DUSP1,ESR1,HMGCS1,IRF1,NR0B2,SFTPB,SREBF1,TGFB2,TK1,WNT5B | NA |
| PTEN | 5.00e-02 | phosphatase | NA | 3.80e-01 | 0.0e+00 | ABCC4,ANGPT1,ARF4,ASPH,AURKA,BCL2L11,BCL3,BRPF1,CCL5,CCND1,CCNE1,CD86,CDC25A,CDKN1A,CELSR3,CHD1,CNNM4,COL11A2,COL18A1,CSTF3,CUL4A,CXCL10,CXCL11,DAAM1,DUSP1,EFNB2,EGR2,EPAS1,ESR1,EZH2,FDFT1,FGF7,FGF9,GPHN,GPR146,GPR157,GPR83,GRB10,HDAC5,HMGCS1,HSD17B7,HSPA1A/HSPA1B,ID4,IFT88,INMT,JUN,L1CAM,LGR5,LOXL3,LRAT,LSS,MAD2L1,MAFK,MMP15,Muc1,MYBL2,NDRG1,NFATC1,NFIL3,NQO1,NR4A2,P2RY14,PABPC4,PARP1,PLK1,PPP2R2B,PRKCB,RAB30,RAD51,RAD51C,RAD51D,RAMP2,RBBP6,RBL2,RNF225,SDC1,SEPHS2,SERPINE1,SETD6,SFTPB,SFTPC,SKP2,SLC5A8,SORD,SOX8,SREBF1,STAT3,TH,THBS1,TLE2,TMEM106A,TNFSF10,TRADD,UCKL1,VEGFC,VIL1,WIPI2 | 677 (23) |
| C1Q (family) | NA | group | NA | 3.80e-01 | 3.0e-02 | BCL2L11,ICAM1,MERTK,mir-154,MX1,PARP1,TNFSF10 | NA |
| THRB | -5.00e-02 | ligand-dependent nuclear receptor | NA | 3.80e-01 | 4.0e-02 | ATP2A2,BCL3,CCND1,CCNE1,CFTR,CLEC10A,CXCL10,CYP27B1,FOSL1,FZD1,FZD7,FZD9,GCH1,JUN,LEF1,LRRC49,NLRP3,NR1H3,Oasl2,P2RY14,PENK,POR,PROM1,SERPINE1,SKP2,SLC7A11,SREBF1,TLE2,TLR2,TNFRSF10A,TNFSF10,TRADD,UCP2,UCP3,WNT5B | NA |
| IL12 (complex) | NA | complex | NA | 3.80e-01 | 2.0e-02 | BCL3,CCL5,CD86,CEACAM1,CISH,CXCL10,CXCL11,CXCR3,DDB2,ERCC5,FUT7,GADD45B,GJA1,GLG1,ICAM1,IFIH1,IL12RB1,IL18,IRF1,ISG20,JUN,RAD23B,RPA1,SOCS1,SOCS2,TFRC,TLR2 | NA |
| RHOA | -3.00e-01 | enzyme | NA | 3.80e-01 | 1.0e-02 | AGT,CCND1,CCNE1,CDKN1A,CXCL10,CXCL11,ECT2,ESR1,ICAM1,IRF1,JUN,NFKBIB,PAK1,SCARB1,SKP2,SREBF1,STAT3 | NA |
| SH3PXD2A-AS1 | NA | other | NA | 3.80e-01 | 0.0e+00 | BDKRB2,CX3CL1,GML,IER3,PCNA,PROM1,SERPINE1 | 497 (11) |
| collagenase | NA | group | NA | 3.80e-01 | 2.0e-02 | CXCL10,FOSL1,ICAM1,IER3,IRF1,JUN,STAT3 | NA |
| IRAK4 | -6.60e-01 | kinase | NA | 3.80e-01 | 2.0e-02 | CD86,CXCL10,GEM,IDE,IRF1,IRF7,JUN,NLRP3,NOCT,OLR1,PDE4B,PLSCR1,SOCS1 | NA |
| eltanexor | NA | chemical drug | NA | 3.80e-01 | 2.0e-02 | CCNE1,CDC25A,FANCG,MCM4,PCNA,POLE2,RAD51 | NA |
| beta-carotene | NA | chemical - endogenous mammalian | NA | 3.80e-01 | 3.0e-02 | GJA1,HSPA1A/HSPA1B,MID1IP1,NR1D1,SCARB1,Scd2,SKP2,THBD | NA |
| MEX3A | 2.70e-01 | other | NA | 3.80e-01 | 4.0e-02 | ANGPTL4,ASCL2,AURKA,CCND1,CIDEC,FZD7,PLK1 | NA |
| ATP7B | 1.20e-01 | transporter | NA | 3.80e-01 | 5.0e-02 | FDFT1,HMGCS1,LSS,MAD2L1,Mt1,RAD51,SMC2 | NA |
| caffeic acid phenethyl ester | NA | chemical drug | NA | 3.70e-01 | 0.0e+00 | ABCB10,ATM,CCND1,CCNE1,CD83,CDKN1A,CXCL10,ESR1,FTL,ICAM1,LEP,NFKBIB,NQO1,OLR1,PCNA,PTGFR,STAT3,TLR2 | 652 (17) |
| PRKCI | -4.60e-01 | kinase | NA | 3.60e-01 | 0.0e+00 | ABCC8,CCND1,CLDN4,CXCL10,ECT2,HK2,IRF1,IRF7,SREBF1,STAT1 | 763 (20) |
| ATM | -6.60e-01 | kinase | NA | 3.60e-01 | 0.0e+00 | ATM,BIRC2,BLM,CCND1,CDKN1A,CHEK2,DUSP1,GADD45A,GADD45B,GPHN,IL33,IRF1,JUN,LEP,PCNA,RRM2,SERPINE1,TGM2 | 660 (22) |
| PP2/AG1879 tyrosine kinase inhibitor | NA | chemical drug | NA | 3.60e-01 | 3.0e-02 | ACE,AGT,BCL2L11,CDKN1A,DSP,DUSP1,FGR,GRIN2C,ICAM1,JAK2,JUP,RRM2,SERPINE1 | NA |
| VEGFA | -4.30e-01 | growth factor | NA | 3.60e-01 | 0.0e+00 | ACE,ADAMTS1,ADRB3,ANGPT1,ANPEP,BCL6B,CAV1,CCND1,CCNE1,CCRL2,CD55,CD83,CD86,CDKN1A,CEACAM1,CLIC4,CSTB,CXCL10,CYB5B,DLL1,DUSP5,EFNB2,GBP1,GJA1,GRB10,HSPA5,ICAM1,ID3,ITGA2,ITGAV,ME2,MMP15,MRPS12,MYCN,NFATC1,NR4A2,PARP1,PCNA,PDGFB,PLAT,PLPP3,PNPLA2,SERPINE1,SFTPB,SFTPC,SLC25A17,THBD,THBS1,TNC,TOMM20,VASH1 | 682 (18) |
| JAK1 | 1.20e-01 | kinase | NA | 3.60e-01 | 0.0e+00 | BCL2L11,BCL3,CDKN1A,ICAM1,IL19,IRF1,IRF7,IRF9,MX1,Oasl2,OSMR,PDGFB,SFTPB,STAT1,STAT2,STAT3,TNFRSF21,USP18 | 582 (18) |
| MDM2 | 1.40e-01 | transcription regulator | NA | 3.50e-01 | 2.0e-02 | CCND1,CDC25A,CDKN1A,EDA2R,EZH2,INHBB,KAT2B,MYCN,NR0B2,POLK,SERPINB2,SERPINE1,THBS1,TNFSF10,WRN | NA |
| miR-16-5p (and other miRNAs w/seed AGCAGCA) | NA | mature microRNA | NA | 3.40e-01 | 0.0e+00 | ABHD10,ANAPC16,CCND1,CCNE1,CCNF,CDC25A,CDK5RAP1,CENPJ,CHORDC1,EIF4E,FGF7,FLT3,GALNT7,GPAM,GRB10,HMGA1,HSPA1A/HSPA1B,HYAL3,ITGA2,JUN,LDAH,MSH2,NFIA,PLK1,PPIF,RAB30,RAD51C,RFT1,SKAP2,SLC38A1,TMEM109,TMEM43,UCP2 | 382 (7) |
| DDB1 | 9.00e-02 | other | NA | 3.40e-01 | 0.0e+00 | AXIN2,CDKN1A,DNAJB1,EGR2,EGR3,ID3,STAT1,TRIB1 | NA |
| MAPK7 | 1.10e-01 | kinase | NA | 3.40e-01 | 0.0e+00 | ADAMTS1,CCND1,CXCL10,DUSP1,HMGCS1,HSD17B7,JUN,KLF4,LSS,NQO1,PLAT,SERPINB2,SREBF1,TH,THBD | 719 (20) |
| diallyl disulfide | NA | chemical - endogenous non-mammalian | NA | 3.40e-01 | 2.0e-02 | CD55,GJA1,NFATC1,NOS1,NQO1,NT5E,PCNA | NA |
| RAC1 | 6.00e-02 | enzyme | NA | 3.40e-01 | 0.0e+00 | Acan,AGT,APBB1,CCND1,CD86,CDC25A,COL2A1,DUSP1,ESR1,FOSL1,GREB1,ICAM1,IL33,JUN,KLF4,NF2,PAK1,PROM1,STAT1,STAT3,WNT5A | 724 (20) |
| tanespimycin | NA | chemical drug | NA | 3.40e-01 | 0.0e+00 | ATM,BRAF,CAV1,CCND1,CDKN1A,COL11A2,DNAJB1,EIF4A1,FDFT1,FLT3,HMGCS1,HNRNPA1,HSPA1A/HSPA1B,HSPA5,JAK2,JUN,LAT,PCNA,SERPINE1,SERPINH1,SREBF1,STAT3,TLR3 | 725 (24) |
| INS | NA | other | NA | 3.30e-01 | 0.0e+00 | Acan,ADAM10,AGT,AQP3,ASPH,CCND1,CDKN1A,CIDEC,COL2A1,DEPTOR,DUSP1,EGR2,EIF4E,FOSL1,GHRL,GRB10,HSPA5,ICAM1,IER3,JUN,LEP,NOS1,NR1H3,PRDM16,PTPN1,SMPD1,SREBF1,SSTR1,UGCG | 766 (24) |
| RET | 2.51e+00 | kinase | NA | 3.30e-01 | 1.0e-02 | ATF4,CCND1,DNAJA1,ELN,ETV1,GFRA1,GJA1,HDAC5,HOPX,HSPA1A/HSPA1B,HSPH1,LOX,MAPKAPK2,MARK3,NOS1,PRKCD,RET,TGFB2,TGM1,TH,TIMP3,TNC,VGF | 733 (22) |
| SAFB | 3.00e-01 | other | NA | 3.30e-01 | 4.0e-02 | CCL5,CX3CL1,CXCL10,CXCL11,ISG20,JUN,L1CAM,NEDD9,TNFSF10 | NA |
| E2f | NA | group | NA | 3.10e-01 | 0.0e+00 | CAV1,CCNE1,CDC25A,CYP27B1,DDX11,E2F4,EPAS1,GMNN,GOLT1B,HDAC1,HNRNPA1,ITGA5,MAD2L1,MCM3,MCM4,MTHFD1,MYBL2,MYCN,NUSAP1,PCNA,POLA1,RAD51,RRM2,SERPINE1,TGM1,UBE2C | 617 (18) |
| TCF7L2 | -8.00e-02 | transcription regulator | NA | 3.10e-01 | 2.0e-02 | ABHD17B,ACSL3,ADAMTS4,AQP3,ARAP2,ARHGEF10,ARHGEF26,ASPH,AXIN2,BAMBI,BIN1,CCND1,CCP110,CDH17,CDK19,CDKN1A,EPAS1,FAM91A1,FBXO32,FMNL2,GJC2,GLP1R,GLTP,HHIP,HSPA2,ID3,ID4,IDH1,IL12RB1,JUN,KAT2B,KLHL2,LAMC2,LEF1,NKX6-2,PIM3,PLAT,PLEKHG1,PRRG1,PSD3,RFFL,SORBS3,SRD5A1,STAT3,STXBP3,TBC1D5,TMEM163,TPRN,UBE2G1,VCAN | NA |
| GNAQ | -2.00e-01 | enzyme | NA | 3.10e-01 | 0.0e+00 | ADAMTS1,AQP5,Arf2,ATP2A2,CCND1,CX3CL1,DUSP5,FOSL1,GADD45A,GJA4,GNRHR,GRB14,HK2,HSPB8,MAFF,NFIA,NFIL3,NR4A2,NR4A3,OLR1,PDE10A,PLAT,PLSCR1,PRKCD,SERPINE1,STAT1,TGFB2,TGM1,THBD,TUBA1C | 755 (23) |
| AMBRA1 | 4.90e-01 | other | NA | 3.10e-01 | 2.0e-02 | ANGPT1,CCND1,CDKN1A,COL11A2,COL18A1,LOXL3,MMP15,SERPINE1,TGFB2 | NA |
| phorbol 12,13-dibutyrate | NA | chemical - endogenous non-mammalian | NA | 3.00e-01 | 3.0e-02 | CD55,CDKN1A,ITGA2,PRKCB,PRKCD,RRM2,SERPINE1 | NA |
| actinomycin D | NA | biologic drug | NA | 3.00e-01 | 0.0e+00 | AGT,AQP5,ARHGEF26,ATF4,BCL2L11,BIRC2,CAV1,CCND1,CD55,CDKN1A,COL2A1,DUSP1,EPAS1,GADD45A,GCH1,GNRHR,HNRNPA1,IL1R2,IRAK4,IRF1,JUN,Mt1,RAD51,SCNN1B,SCNN1G,SERPINE1,SKIL,SLC30A1,TLR2,TNFRSF10A,TRAF1,UBE2D1,VDR,VEGFC | 707 (15) |
| wortmannin | NA | chemical drug | NA | 3.00e-01 | 0.0e+00 | AGT,ANPEP,AQP3,BCL2L11,CCL5,CCND1,CDKN1A,CIDEC,CKB,CX3CL1,CXCL10,DLG2,ESR1,F2R,GRIN1,ICAM1,IDE,IRF1,JUN,LEP,NR4A3,NT5E,OPRD1,P4HA1,PCNA,SCARB1,SERPINE1,SOCS2,SREBF1,TFRC,TH,TNFSF10 | 780 (20) |
| SNAI2 | -1.50e-01 | transcription regulator | NA | 2.90e-01 | 0.0e+00 | Acan,BCL2L11,CCND1,CDKN1A,COL2A1,DSP,EGR2,HES6,ID4,JUP,L1CAM,MAPKAPK2,OLR1,PROM1,STAT3,VDR | 557 (15) |
| TGM2 | 1.84e+00 | enzyme | NA | 2.90e-01 | 0.0e+00 | Acan,ATXN1,CCL24,CCND1,CCRL2,CD86,CEACAM1,CXCL10,EHD1,GJA1,GTPBP10,IFI35,IRF9,ITGAX,MERTK,OAS2,ORC3,PAK1,PARP14,PARP9,PLSCR1,PNRC1,POR,RNF213,RTKN2,SERPINB2,SLC16A1,SLC25A15,SLFN5,SMPD1,SP110,STAT1,THBS1,TNIP1,TUBGCP5 | 599 (20) |
| phorbol esters | NA | chemical - other | NA | 2.80e-01 | 5.0e-02 | BCAR1,CRYAA/LOC102724652,DUSP1,HK2,HOXB7,JUN,PLAT,PRKCB,PTPRO,SLC9A3,TGM1,TNFSF10,VDR | NA |
| RELA | 2.10e-01 | transcription regulator | NA | 2.80e-01 | 0.0e+00 | ACTN4,AGT,ASCL2,BCL2L11,BCL3,BHLHE40,BIRC2,BLVRA,CAV1,CCL5,CCND1,CDKN1A,CFTR,COL2A1,CX3CL1,CXCL10,CXCL11,DIO2,DOCK8,DUSP1,ELN,EPAS1,FSCN1,GBP1,GCH1,ICAM1,IER3,IL15RA,IL20,INPP4B,IRF1,IRF2BP2,IRF7,ISG20,JUN,LEF1,LGR5,NF2,NFATC1,NFKBIB,NR4A2,NR4A3,OAS2,OLR1,OPRD1,ORAI1,PARP1,PDE4B,PDGFB,PLK1,PRKCD,SFI1,SLC2A5,SREBF1,TERF2IP,TGM2,TLR2,TNFRSF10A,TNIP1,TRAF1 | 734 (15) |
| NFYA | -7.50e-01 | transcription regulator | NA | 2.80e-01 | 0.0e+00 | CDKN1A,CHEK2,GADD45A,GADD45B,GPAM,HSD17B7,HSPA5,ICAM1,IRF1,JUN,MLH1,OGG1,POLA1,RRM2,Scd2,UBE2I | 705 (18) |
| CRKL | NA | kinase | NA | 2.80e-01 | 1.0e-02 | CXCL10,IL15RA,ISG20,PLA1A,TLR3 | NA |
| PRPF19 | -7.10e-01 | enzyme | NA | 2.80e-01 | 1.0e-02 | CDKN1A,DGAT1,GPAM,PLIN4 | NA |
| MAFG | -1.20e-01 | transcription regulator | NA | 2.80e-01 | 2.0e-02 | ABCC4,HMBS,ITGA2B,NQO1,TNFSF18,TXNRD1 | NA |
| resiquimod | NA | chemical drug | NA | 2.70e-01 | 0.0e+00 | ACTG1,APPL2,ATF4,ATM,CCL24,CCL5,CCRL2,CD55,CD83,CD86,CLEC7A,CXCL10,CXCL11,DHX58,DLL1,F2R,FLT3,GBP1,HDAC5,HIVEP2,HSPA5,ICAM1,IER3,IFI16,IFI44L,IL18,IL19,IL33,IRAK2,IRF7,IRF9,ISG20,ITGAX,JUN,MLH1,MX1,NLRP3,OAS2,PDE4B,PDE4D,PLAT,PLSCR1,PML,PRKCB,PRKDC,PTPN1,SEMA4B,STAT1,STAT2,TFRC,TLR2,TNFSF10,TNIP1,XRCC6 | 692 (20) |
| Z-LLL-CHO | NA | chemical - protease inhibitor | NA | 2.70e-01 | 0.0e+00 | AKR1B1,ATF4,AURKA,BAD,BCAR1,BCL2L11,CCL5,CCND1,CDKN1A,CDKN1C,CHD1,CISH,CLDN4,CRYAA/LOC102724652,CXCL10,CYP27B1,DDB2,DUSP1,EIF4E,EIF5A,EPAS1,ESR1,EZH2,FANCC,GCH1,HDAC1,HNF1A,HNRNPL,HSPA5,ICAM1,IER3,IRAK4,IRF7,JUN,KCNH2,MAD1L1,MLH1,MYCN,NQO1,OGG1,OPRD1,PARP1,PEX5,PTGFR,RAD51,RGS7,SFTPB,SKP2,STAT1,STAT2,THBS1,TNFRSF10A,VDR,XPA | 771 (22) |
| eicosapentenoic acid | NA | chemical drug | NA | 2.70e-01 | 5.0e-02 | ANGPTL4,CD83,CD86,ELN,FADS1,IL1R2,ITGAX,JUN,LEP,PNPLA2,PROM1,SERPINE1,SREBF1,TGFB2 | NA |
| IRF2 | -4.80e-01 | transcription regulator | NA | 2.60e-01 | 0.0e+00 | C1QTNF1,CCND1,CDKN1A,CEACAM1,CFTR,CIDEC,CLEC10A,CXCL10,DNAJB6,DUSP5,GBP1,GSDMD,HK2,IDH1,IFI35,Ifi47,IRF1,IRF7,KLF4,SDC1,SOCS1,TLR3,TLR5,TNFSF10,TRIM21,TXNRD1,USP18 | 346 (17) |
| IL17A | -4.00e-02 | cytokine | NA | 2.60e-01 | 0.0e+00 | BCL3,CCL5,CCND1,CD83,COL2A1,CX3CL1,CXCL10,Cxcl3,EGR2,FMO1,FOSL1,GADD45A,HSPB8,ICAM1,IL18,IL19,IL20,IL33,IRF1,JUN,LEP,LOX,MAP2K3,MERTK,METRNL,mir-154,NFATC1,NR4A2,OSMR,PLAT,PTGFR,SERPINE1,SLC9A3,SOCS1,SREBF1,STAT1,STAT3,THBD,TIMP3,TLR2,TLR3,TNC,VEGFC | 725 (16) |
| KMT2A | 3.30e-01 | transcription regulator | NA | 2.60e-01 | 0.0e+00 | 1700056E22Rik,ARMT1,BAHCC1,CDKN1A,CLCN3,DEPTOR,HOXB6,HOXB7,KNL1,Meis1,MKX,PBX1,PRDM16,PROM1,SCARB1,TRIB1,ZFAND2A | 635 (14) |
| CYP27B1 | 8.50e-01 | enzyme | NA | 2.60e-01 | 3.0e-02 | CCND1,CYP27B1,IL18,S100G,STAT3,TLR2,TRPV6,VDR | NA |
| SOX1 | NA | transcription regulator | NA | 2.60e-01 | 0.0e+00 | ANGPT1,BMPER,DSP,DUSP1,DUSP5,EXT2,FARP1,GBP4,GREB1,KIF16B,Oasl2,TGFB2,TXNRD1,USP18,WNT5A | NA |
| GMNN | 7.10e-01 | transcription regulator | NA | 2.60e-01 | 0.0e+00 | ANGPT1,BMPER,CDKN1A,DSP,DUSP1,DUSP5,EXT2,FARP1,GBP4,GREB1,KIF16B,Oasl2,TGFB2,TXNRD1,USP18,WNT5A | NA |
| cytokine | NA | group | NA | 2.60e-01 | 0.0e+00 | ADAMTS4,BCL3,CCL5,CCND1,CCNE1,CD86,CISH,CX3CL1,DUSP1,ICAM1,IRF1,JUN,LEP,LIPG,NOS1,PCNA,PLAT,SERPINE1,SOCS1,SOCS2,STAT3,TGFB2,TLR2,UPP1 | 698 (18) |
| LYL1 | 3.20e-01 | transcription regulator | NA | 2.50e-01 | 5.0e-02 | DLG5,ID3,ID4,ITGA2,TSPAN18 | NA |
| poly dA-dT | NA | chemical reagent | NA | 2.50e-01 | 4.0e-02 | CCL5,CXCL10,ICAM1,IL18,IRF7,STAT1 | NA |
| FOXO4 | -2.50e-01 | transcription regulator | NA | 2.50e-01 | 0.0e+00 | Acan,ANGPT1,BCL2L11,CAV1,CCND1,CDC42EP3,CDKN1A,COMP,ELOVL5,ELOVL7,FDFT1,GADD45A,GADD45B,HMGCS1,HSPA5,IER3,IL10RB,LRAT,PDIA4,PRCP,PRKCD,RBL2,Scd2,SERPINE1 | 593 (23) |
| volasertib | NA | chemical drug | NA | 2.50e-01 | 2.0e-02 | ESR1,GADD45A,MSH5,NCAPG2,POLA1 | NA |
| MYOD1 | NA | transcription regulator | NA | 2.40e-01 | 4.0e-02 | ADORA1,AGT,ARID3A,BIN1,CCNE1,CDKN1A,CDKN1C,DUSP1,ENO3,ESR1,FOSL1,GADD45A,HDAC11,HES6,HSPB8,IFI16,KIF18B,KIFC3,KNL1,MYO5B,NUSAP1,PLK1,PMEPA1,PRDM16,PRIMA1,RRM2,STAT1,TGFBR3,TRIM21,UCP3 | NA |
| CD36 | -2.00e-01 | transmembrane receptor | NA | 2.40e-01 | 2.0e-02 | ADAMTS4,ATP2A2,CCL5,CD86,DGAT1,HSPA5,ICAM1,IRAK4,LEP,NLRP3,PDGFB,PNPLA2,PTPN1,SERPINB2,SERPINE1,TNFRSF10A | NA |
| EGR2 | 1.05e+00 | transcription regulator | NA | 2.20e-01 | 0.0e+00 | ACAT2,ATXN1,BCL2L11,BHLHE40,CDKN1A,CISH,DIO2,EGR2,FCHSD2,FXYD5,GALNT7,HMGCS1,HOXB7,HSPA5,ID3,ID4,IL1R2,JUN,MAP2,NCL,NDRG1,NECTIN1,NFIL3,PDE4A,PRKCD,PSD,RAB20,RASAL1,RORA,SLC16A1,SLC4A3,SOCS1,TBC1D9,TFRC,TGFBR3,TNFSF10,TOLLIP,TRAF1,TSC22D1,UCP3,XKRX | 659 (18) |
| RAD9A | -7.50e-01 | enzyme | NA | 2.20e-01 | 0.0e+00 | CDC25A,CDKN1A,MAP2K5,SATB1 | 337 (7) |
| FANCA | -2.60e-01 | other | NA | 2.20e-01 | 0.0e+00 | CDKN1A,FANCG,GNRHR,PROX1,WNT5A | NA |
| LIN28B | NA | other | NA | 2.20e-01 | 1.0e-02 | ASCL2,AXIN2,CDKN1A,COL11A2,COL2A1,LGR5,MYCN,PROM1,SCX,SOX11,SREBF1,TGFBR3 | NA |
| mir-802 | NA | microRNA | NA | 2.20e-01 | 1.0e-02 | ANGPT1,ARHGEF10,CDC42EP3,CDH17,CDK19,EFNB2,ERMP1,F2R,FGF12,FMO1,HEG1,ITGAV,LIPG,MBNL1,MRAS,PDGFC,PDGFD,PRDM16,RDX,SLC28A3,VEGFC | NA |
| PRKACA | -3.80e-01 | kinase | NA | 2.10e-01 | 0.0e+00 | BCL2L11,CCND1,DIO2,GNRHR,HSPA1A/HSPA1B,LEP,OXTR,PENK,PRKACB,SDC1 | 752 (24) |
| RUNX1 | 1.00e-01 | transcription regulator | NA | 2.10e-01 | 0.0e+00 | ATF4,BCL2L11,CCND1,CDKN1A,CDKN1C,CPOX,CSF2RB,DEPTOR,EGR2,EPAS1,FHDC1,FSCN1,FUT7,GNA15,GNL3,GPAM,GPATCH4,HSPA5,Igtp,IRF7,Irgm1,ITGA2,ITGA2B,ITGAV,KCTD6,KRT80,MAD2L1,Mt1,NFIL3,NR4A3,Oasl2,OGG1,PARP1,PLXND1,PPAN,PRKCB,SEC61A1,SERPINE1,SHANK2,ST3GAL5,STAT1,STAT3,TPSAB1/TPSB2,TRIB1,UGCG,UPP1 | 825 (26) |
| aphidicolin | NA | chemical toxicant | NA | 2.00e-01 | 0.0e+00 | CDKN1A,GADD45A,IFI16,IFI44L,ISG20,MX1,STAT1,TK1 | 706 (25) |
| Hbb-b1 | NA | transporter | NA | 1.90e-01 | 2.0e-02 | BCL2L11,CLEC7A,CXCL10,CXCR3,FTL,ICAM1,Mt1,NDUFA5,RET,TFRC,TH,TLR2,UCP2,VEGFC | NA |
| VTN | -5.90e-01 | other | NA | 1.80e-01 | 4.0e-02 | BHLHE40,CDKN1A,EFNB2,IRF9,ITGA5,SERPINE1 | NA |
| ELAVL1 | 4.00e-02 | other | NA | 1.80e-01 | 1.0e-02 | ANXA11,APPL2,CCNE1,CD83,CD86,CDKN1A,DGAT1,DUSP1,GLP1R,HNRNPD,HSPA2,IFI16,IFI44,IFIH1,IL1R2,IRF1,IRF9,Irgm1,MYBL2,NCL,Oas1b,OAS2,PRC1,PROM1,REN,SLC7A11,SLC7A7,STAT1,STAT3,TLR2,USP18,WNT5A | NA |
| POU5F1 | NA | transcription regulator | NA | 1.80e-01 | 1.0e-02 | ACKR3,ANGPT1,BAD,BCL2L11,BIRC2,BMPER,BRAF,CCL5,CCND1,CCNF,CDKN1A,CXCL10,DSP,DUSP1,DUSP5,EXT2,FARP1,GADD45A,GBP4,GREB1,HK2,HOPX,ID3,IRF6,JARID2,KIF16B,KLF4,Meis1,MYBL2,MYCN,NF2,Oasl2,ORAI1,PARP1,PCSK6,PMEPA1,PROM1,RAD54L,SMPD1,TFAP4,TFCP2L1,TGFB2,TGM1,TNFRSF10A,TNFRSF21,TNFSF10,TXNRD1,USP18,WNT5A | 593 (21) |
| GLI3 | 2.20e-01 | transcription regulator | NA | 1.80e-01 | 1.0e-02 | CCND1,CUL4A,DLL1,DLL3,DUSP1,DUSP5,GREM1,HHIP,IRF1,MAPKAPK2,MYCN,OSR1,TBX6,TGFB2,TNFRSF10A,WNT5A | 345 (7) |
| metribolone | NA | chemical reagent | NA | 1.80e-01 | 2.0e-02 | ABCC4,ACSL3,ADAMTS1,AKNA,Akr1b7,APPBP2,ATP6V1E1,CAV2,CCND1,CDKN1A,CLN6,CPOX,ELOVL5,ETV1,FADS1,FDFT1,GREB1,HES6,HIBCH,HK2,HMGCS1,HSPA5,HSPH1,INPP4B,ISG20,Ldha/RGD1562690,MERTK,MRPL34,NCOA2,NDRG1,NPEPPS,PDE4D,PDLIM5,PMEPA1,POR,PRKACB,PRKCD,RRP12,SAP30,SOCS1,SORD,SPDEF,SPON2,SRD5A1,SREBF1,STEAP2,THBS1,TIMM9,TRIM36,TSC22D1,UBE2J1,UNC13B,VCAN,WDR19,ZMIZ1 | NA |
| mir-8 | NA | microRNA | NA | 1.70e-01 | 4.0e-02 | ABL2,ADAMTS1,CCND1,CDC25A,CDKN1A,DDIT4L,EZH2,Fhod1,HDAC4,ITGAV,KLF4,LOX,LSR,MCM4,MYOF,PHLDA3,PPP2R1B,PROM1,RNF128,SKP2,TGFB2,TIAM1,TSPAN1,UBE2D1,ZFPM2 | NA |
| doxorubicin | NA | chemical drug | NA | 1.70e-01 | 0.0e+00 | ADAM10,ADAMTS1,ASNS,ATG7,ATM,ATP2A2,AURKA,BAD,BCL2L11,Bex2/LOC100912195,BHLHE40,BIRC2,CCND1,CDCP1,CDKN1A,CGREF1,CHEK2,CLDN4,CTF1,Ctla2a,CXCL10,DENND2C,DUSP1,DUSP5,EIF5A,EPOR,ESR1,FGF11,FGF13,FGF16,GADD45A,GTPBP4,HDAC1,HSPH1,IER3,IRF1,IRF7,Irs3,JAK2,JUN,KAT2B,LAMC2,MAD2L1,MCM3,NDRG1,NLRP3,NPHS2,NQO1,NRG1,NT5E,PCNA,PINX1,PLA1A,PLK1,PMEPA1,PRC1,RAD51,RBL2,RBM3,RGS7,RRM2,RRP1B,STAT1,STAT3,TERF2IP,TEX15,TGM2,TK1,TMEM19,TNFRSF10A,TNFRSF21,TNFSF10,TRIM63,TSPAN8,TTLL9,UGCG,UPP1,YBX1,ZBTB42 | 688 (23) |
| LUCAT1 | NA | other | NA | 1.60e-01 | 1.0e-02 | CDKN1A,CDKN1C,CLDN4,GLRX,HNF1A,IER3,NR4A2 | NA |
| 5-fluorouracil | NA | chemical drug | NA | 1.60e-01 | 4.0e-02 | ANKRA2,AQP5,ATF4,BAIAP2,BCL2L11,BIRC2,CCND1,CD86,CDKN1A,CGRRF1,CLDN18,CSTB,CSTF1,DDB2,DLL1,EIF1,EIF3C,EIF4A1,GADD45A,HNRNPA1,JUN,MAD1L1,NCL,NOP56,OAZ1,PHLDA3,PRC1,PROCR,RAD9A,RGS7,SDC1,SEC61A1,SKP2,SLC7A11,THBS1,TLR3,TSC22D1,UBE2C,UPP1,VDR,YBX1,ZNF43 | NA |
| NTRK2 | 3.10e-01 | kinase | NA | 1.60e-01 | 0.0e+00 | ANGPT1,BAD,BCL2L11,CCND1,CCNE1,CDKN1A,DDX11,Muc1,MYCN,PCNA,SERPINE1,SLC12A5,SLC31A1,THBS1,TNFSF10 | 678 (21) |
| Akt | NA | group | NA | 1.60e-01 | 0.0e+00 | ANGPT1,AQP3,ATF4,ATG7,BAD,BCL2L11,BHLHE40,BIRC2,CCND1,CDKN1A,CDKN1C,COL2A1,CPM,CXCL10,E2F4,EGR2,EPAS1,EPRS1,ESR1,EXT1,EXT2,EZH2,FBXO32,FOSL1,GNPTAB,HK2,IER3,JUN,KCNA5,L1CAM,LAMB3,LAMC2,LEF1,LEP,MAP2,MSI1,MYCN,NDRG1,NET1,NFATC1,NFIL3,NOS1,NR0B2,NT5E,PCNA,PRDM16,RAD51,RPL9,RRM2,SCARB1,SERPINE1,SKP2,SLC6A14,SLC7A5,THBS1,TLR2,TNC,TNFSF10,TRADD,UCP3,VCAN | 798 (23) |
| PCLAF | NA | other | NA | 1.60e-01 | 0.0e+00 | AURKA,CDKN1A,ECT2,KLF4,MAD2L1,PLK1,TGFB2,UBE2C | 384 (11) |
| PI3K (family) | NA | group | NA | 1.60e-01 | 1.0e-02 | ATG7,BCL2L11,CXCL10,CXCL11,ESR1,FBXO32,HSPA5,LEP,NQO1,PDGFB,SCARB1,SERPINE1,SKIL,SREBF1,TGM2,THBS1,TNC,TNFSF10 | 797 (24) |
| tranylcypromine | NA | chemical drug | NA | 1.50e-01 | 0.0e+00 | CCL5,CDKN1A,CXCL10,NFATC1,PDE4A,PDE4B,RASSF1,TH | 302 (7) |
| ROR2 | -4.60e-01 | kinase | NA | 1.50e-01 | 0.0e+00 | AURKA,AXIN2,BMP7,CCND1,CCNE1,CDC25A,CDK5RAP1,CDKN1A,CHEK2,IDE,MAP2,MCM3,MCM4,MUC13,RBL2,SRFBP1,TRUB1,WNT5A | 592 (14) |
| MYOC | 7.20e-01 | other | NA | 1.50e-01 | 0.0e+00 | ADAMTS1,EGR2,FBXO32,FSCN1,HHIP,HSPA5,KCNJ2,MAFK,PLXNC1,PRKCB,SLC7A11,SOX11,STC2,TRIM63,UPP1,VAPA | NA |
| FSCN1 | -9.30e-01 | other | NA | 1.50e-01 | 1.0e-02 | CXCL10,IRF7,SLC7A11,THBS1 | NA |
| puromycin | NA | chemical - endogenous non-mammalian | NA | 1.50e-01 | 2.0e-02 | HSPA5,RBM3,SERPINE1,SKIL,XPO1 | NA |
| IQGAP2 | -5.70e-01 | other | NA | 1.50e-01 | 3.0e-02 | CCND1,FOSL1,LEF1,WNT5A | NA |
| ACE | 8.30e-01 | peptidase | NA | 1.50e-01 | 3.0e-02 | ACE,AGT,CCL24,CCL5,REN,SERPINE1 | NA |
| PPP1R15A | NA | other | NA | 1.50e-01 | 3.0e-02 | ATF4,CA9,CCND1,GADD45A,HSPA5 | NA |
| lipopolysaccharide | NA | chemical drug | NA | 1.50e-01 | 0.0e+00 | ABCB10,ABCC4,ACE,ACKR3,ACTN4,ADAMTS1,ADAMTS4,ADORA1,AGER,AGT,ANGPTL4,ANXA11,APLNR,APOC2,AQP3,AQP5,Arf2,ASCC3,ATF4,ATG7,ATP2A2,AXIN2,BAMBI,BCL2L11,BCL3,BIRC2,CARD11,CARNMT1,Casp12,CAV1,CCDC170,CCL24,CCL5,CCND1,CCNE1,CCNF,CCRL2,CD200,CD300LF,CD55,CD83,CD86,CDC25A,CDC42EP2,CDC42EP3,CDKN1A,CEACAM1,CFTR,CISH,CLEC10A,CLEC4D,CLEC7A,CLIC4,CLIC5,CSF2RB,CSTB,CX3CL1,CXCL10,CXCL11,Cxcl3,CXCR3,CYP27B1,DDX27,DGAT1,DHX58,DIDO1,DIO2,DLL1,DNAJB1,DOCK8,DTX3L,DUSP1,DUSP5,EDA2R,EDEM2,EFNB2,EGR2,EGR3,EHD1,Eif1,ELK3,ELN,ENTPD7,EPAS1,EPOR,EPSTI1,ETV6,EXT1,EZH2,F2R,FBXO32,FMNL2,FOSL1,FSCN1,FZD1,FZR1,GADD45A,GADD45B,Gar1,GAS1,GBP1,GBP4,GBP5,GCH1,GCHFR,GEM,GHRL,GJA1,GLRB,GLRX,GNA15,GNL3,GNRHR,GOLGA4,GOLT1B,GPC4,GREB1,GREM1,GSDMD,GSTT2/GSTT2B,H2-T24,HAS1,HDAC11,HEG1,HIVEP2,HK2,HMGA1,HNF1A,HOPX,HSPA1A/HSPA1B,HSPA5,ICAM1,ID3,IDH1,IER3,IFI16,IFI35,IFI44,IFI44L,Ifi47,IFIH1,Igtp,IL10RB,IL12RB1,IL15RA,IL18,IL19,IL1R2,IL20,IL33,INHBB,IPO5,IRAK2,IRAK4,IRF1,IRF7,IRF9,Irgm1,ISG20,ITGA2,ITGA5,ITGAV,ITGAX,ITPKC,JAK2,JUN,KCNJ1,KCNK5,KDELR2,KLF4,Klrk1,LACC1,LASP1,LAT,LDB2,LEP,LILRB4,LIPG,LOX,LRRC58,LTA4H,LY6D,MAD2L1,MAFF,MAGED1,MAN1B1,MAP2K3,MARCKSL1,MEFV,Meis1,MERTK,METRNL,mir-154,MRAS,Mt1,MTHFD2,MTMR14,MX1,MYBL2,MYCN,NCAPG2,NCL,NCOA2,NCOA7,NDRG1,NECTIN4,NFATC1,NFIL3,NFKBIB,NKX6-2,NLRP3,NOCT,NOS1,NPHS2,NQO1,NR0B2,NR1H3,NR1H4,NR4A2,NR4A3,NSFL1C,NUSAP1,Oas1b,OAS2,Oasl2,OLFML2B,OLR1,ORAI1,OSBPL3,OSCAR,OSMR,P2RY14,P4HA1,PAK1,PARP14,PARP3,PARP9,PAWR,PCNA,PCSK6,PDE10A,PDE3B,PDE4B,PDGFB,PDIA4,PENK,PEX14,PIK3AP1,PIK3R5,PLAT,PLIN4,PLK1,PLPP5,PLSCR1,PMEPA1,PML,PNPLA1,PNRC1,POLA1,PRC1,PRKCB,PROCR,PTGFR,PTPRO,PTPRU,RAB20,RAPGEF3,RDH13,RGS7,RNF213,RORA,RTP4,SAA2-SAA4,SAP30,SATB1,SCARB1,Scd2,SCNN1A,SCNN1B,SCNN1G,SCUBE2,SDC1,SEC61A1,SERPINB2,SERPINE1,SERPINH1,SETD6,SFTPB,SFTPC,SGMS2,SKIL,SLC22A8,SLC30A1,SLC31A1,SLC39A10,SLC3A2,SLC5A1,SLC7A11,SLC7A5,SLC9A3,Slco1a4,SLCO2A1,SLFN13,SMC2,SNAPC2,SNCAIP,SOCS1,SOCS2,SPR,SREBF1,ST3GAL5,STAP2,STAT1,STAT2,STAT3,STX11,TELO2,TFDP2,TFEB,TFRC,TGFB2,TGFBR3,TGM2,TH,THBD,THBS1,TIMP3,TLR2,TLR3,TLR5,TMEM19,TNC,TNFSF10,TNFSF18,TNIP1,TOLLIP,TPT1,TRADD,TRAF1,TRIB1,TRIM21,TRIM6-TRIM34,TRIM63,TSC22D1,TTC39B,TUBB4B,TWF2,TYK2,Ubb,UBE2C,UBE2I,UBE2J1,UCP2,UCP3,UNC119,UPP1,USP18,VCAN,VCL,VDR,VEGFC,WNT5A,YBX1,ZBTB42,Zfp658,ZNFX1 | 792 (18) |
| NR3C1 | -2.70e-01 | ligand-dependent nuclear receptor | NA | 1.50e-01 | 0.0e+00 | ADRA1D,AGT,ANGPTL4,AQP5,ATXN1,BCL2L11,BHLHE40,BIN1,BIRC2,BRAF,C1QTNF1,CAV1,CCL5,CCND1,CCRL2,CD83,CDC42EP3,CDKN1A,CDKN1C,CIDEC,COQ8B,CORO1C,CSRNP2,CUL4A,CXCL10,Cxcl3,DUSP1,DUSP22,ELMOD2,ELMOD3,F2R,GADD45A,GADD45B,GAS1,GEM,GPR83,GRIA3,GRIN1,GRIN2C,H6PD,HDAC1,ICAM1,IDH1,IER3,IFIH1,IGFALS,IL15RA,IL18,IL33,ING1,IRF1,ITGAV,JUN,LEP,LGALS12,LIPC,LOX,MAP3K14,MBD2,MLF1,Mt1,Mt1m/Mt2A,MTHFD1,NAV3,NFATC1,NFIL3,NFKBIB,NLRP3,NQO1,NR0B2,OLR1,PAK1,PAWR,PDE4B,PIM3,PLAT,PNPLA2,PPP2R1B,PPP3CC,PRKACB,PRKCB,PRKCD,RAPGEF4,RELT,S100G,SCARB1,SCNN1A,SERP2,SERPINE1,SFTPC,SLC1A7,SLC2A5,SLC38A1,STAT3,TADA3,THBD,THBS1,TIMP3,TK1,TLR2,TLR5,TNFRSF10A,TNFRSF21,TRAF1,TRIM45,UGCG,UNC13B,VDR,WDR12,WNT5A,ZFYVE28 | 807 (18) |
| eflornithine | NA | chemical drug | NA | 1.50e-01 | 0.0e+00 | ATF4,CDKN1A,ITGAX,MAD2L1,MYCN,PCNA,PLK1,SERPINE1,SLC3A2,TGM2 | 827 (20) |
| KLF4 | 7.40e-01 | transcription regulator | NA | 1.50e-01 | 0.0e+00 | ADAMTS1,ANGPT1,ATP2A2,BMPER,CCND1,CDKN1A,CDKN1C,CLEC10A,CLIC4,DLL1,DSP,DUSP1,DUSP5,ETV1,EXT2,FARP1,GADD45A,GBP4,GREB1,ID3,IRF6,KIF16B,KLF4,LGR5,MSI2,NF2,Oasl2,PLAT,PROM1,SCARB1,SERPINB2,SERPINE1,SERPINH1,SOCS1,SUPT3H,TFAP4,TGFB2,TGM1,THBD,THBS1,TNC,TNFSF10,TPK1,TXNRD1,USP18,WNT5A | 723 (24) |
| MAP2K4 | -7.00e-02 | kinase | NA | 1.40e-01 | 0.0e+00 | CCL5,CCND1,CD86,CDKN1A,CXCL10,GADD45A,GNRHR,JUN,PAK1,STAT3,TUBB2A,VDR | 643 (20) |
| selumetinib | NA | chemical drug | NA | 1.40e-01 | 1.0e-02 | ABL2,BCL2L11,CCND1,CDKN1A,FGR,FOSL1,ITGA2,JAK2,JUN,LAMB3,MERTK,RET,TNFRSF10A | 699 (21) |
| dinoprost | NA | chemical - endogenous mammalian | NA | 1.40e-01 | 0.0e+00 | Acan,ATP2A2,CCND1,ESR1,HSPA1A/HSPA1B,ID3,JUN,NFIL3,NR4A2,PDIA4,POR,PTGFR,THBS1,TIMP3 | 756 (23) |
| SKP2 | 6.20e-01 | other | NA | 1.40e-01 | 2.0e-02 | CCND1,CCNE1,CDKN1A,EZH2,PCNA,RBL2,SKP2,USP18 | NA |
| palbociclib | NA | chemical drug | NA | 1.30e-01 | 0.0e+00 | ANGPT1,CCND1,CD83,CDKN1A,CXCL10,DUSP1,EGR3,GADD45A,GADD45B,GBP4,IFI44,IRF7,IRF9,JUN,MAP2K3,MX1,NR4A2,OLR1,PRKCB,TK1,USP18 | 650 (22) |
| PPARGC1B | 3.30e-01 | transcription regulator | NA | 1.30e-01 | 4.0e-02 | CCND1,CKB,DGAT1,DIO2,FBXO32,FDFT1,GPAM,HK2,LSS,MCM4,TRIM63 | NA |
| bezafibrate | NA | chemical drug | NA | 1.30e-01 | 0.0e+00 | ABCD1,ANGPTL4,APOC2,HSPA5,ICAM1,JUN,LEP,LY6D,MPG,NR1H3,OGG1,PCNA,PEX11A,PEX14,SERPINE1,UCP2,UCP3 | 628 (18) |
| 48s | NA | complex | NA | 1.30e-01 | 0.0e+00 | ATF4,CCND1,HSPA5,MYCN,NKX6-2,SREBF1 | NA |
| S-(2,3-bispalmitoyloxypropyl)-cysteine-GDPKHPKSF | NA | chemical reagent | NA | 1.30e-01 | 1.0e-02 | CCL5,CD86,CXCL10,ICAM1,SERPINE1,TLR2 | NA |
| NFkB (family) | NA | group | NA | 1.30e-01 | 1.0e-02 | ASIC1,CCL5,CCND1,CXCL10,ESR1,GSDMD,IL18,IL33,IRF1,NLRP3,PLAT,RRM2,TNFSF10 | NA |
| PCSK9 | 4.00e-02 | peptidase | NA | 1.30e-01 | 2.0e-02 | CDKN1A,ICAM1,IRF7,ISG20,OLR1,STX11,TLR2 | NA |
| IL12A | 1.50e-01 | cytokine | NA | 1.20e-01 | 0.0e+00 | CCL5,CD86,CXCL10,ICAM1,IL12RB1,IRF9,SOCS1,STAT1,STAT2,STAT3 | 616 (17) |
| dithiothreitol | NA | chemical reagent | NA | 1.20e-01 | 4.0e-02 | ATP2A2,CCND1,GADD45A,HSPA5,NR0B2,TLR2 | NA |
| CDH2 | -1.40e-01 | other | NA | 1.20e-01 | 1.0e-02 | CCND1,CDKN1A,JUN,KCNA5,NDRG1,TH | NA |
| GNRH1 | 6.30e-01 | other | NA | 1.20e-01 | 1.0e-02 | CHRNA9,EGR2,GNRHR,INHA,INHBB,JUN,MCM3,NOS1,NPTX2,PLAT,PRKCD,RTN4IP1 | 712 (21) |
| FOXF1 | 5.80e-01 | transcription regulator | NA | 1.20e-01 | 2.0e-02 | ANGPT1,CCND1,CCNE1,CDKN1A,ITGA5,PDGFB,WNT5A | NA |
| RUVBL1 | 2.00e-01 | transcription regulator | NA | 1.10e-01 | 0.0e+00 | AXIN2,CARS1,GADD45B,MCM3,MCM4,NUDCD2,PCNA,POMK,SLC39A7,SRD5A1,TMEM19 | 422 (8) |
| MAFK | 9.70e-01 | transcription regulator | NA | 1.00e-01 | 5.0e-02 | ABCC4,HMBS,ITGA2B,NQO1,TXNRD1 | NA |
| IKBKB | -2.40e-01 | kinase | NA | 1.00e-01 | 4.0e-02 | AGER,BIRC2,CCL5,CCND1,CDKN1A,CX3CL1,CXCL10,ECT2,EZH2,FSCN1,GADD45A,GCH1,HAS1,HK2,ICAM1,IFI16,IRF1,Mt1,MX1,NFKBIB,NLRP3,NOCT,PLK1,RABEP2,SERPINB2,SKP2,SOCS1,SOCS2,STAT3,TERF2IP,TIMP3,TLR3,TNC,TRIM63,VCAN | NA |
| methylnitronitrosoguanidine | NA | chemical toxicant | NA | 1.00e-01 | 0.0e+00 | CCND1,CDKN1A,CEACAM1,CGRRF1,GADD45A,IRF1,MSH2,PLAT,SERPINE1,TNFSF10 | 650 (22) |
| TCF3 | 7.00e-02 | transcription regulator | NA | 1.00e-01 | 0.0e+00 | ABCC8,ATOH8,AURKA,AXIN2,BCL2L11,BHLHA15,CCNE1,CD200R1,CD55,CDKN1A,CGREF1,CTRB2,E2F4,ECT2,EPOR,EPRS1,ESR1,FLT3,GADD45A,GADD45B,GPAM,HMMR,ID3,IFI16,IRF1,JUN,KLF4,LDLRAD4,LEF1,LILRB4,LY6D,MAD2L1,MYCN,NFIL3,NR0B2,NR4A3,NUSAP1,PDIA4,PLPP5,PML,PRC1,PTPRU,RORA,RRM2,SCX,SEMA4A,SLC7A5,SOCS1,TFCP2L1,TOX2,TXNDC5,XRCC6 | 266 (11) |
| Rxr | NA | group | NA | 1.00e-01 | 3.0e-02 | ABCB10,ADAM10,Akr1b7,ANGPTL4,AQP3,BMP7,CDKN1A,GADD45A,LEP,NR0B2,NR1H3,PDGFB,POR,PTPRO,Slco1a4,SREBF1 | NA |
| Hdac | NA | group | NA | 1.00e-01 | 1.0e-02 | ADAMTS1,CCND1,CDKN1A,CX3CL1,DLL1,E2F4,EGR3,EZH2,FBXO32,FOSL1,GADD45B,JUN,JUP,KCNH2,LRP2,MYBL2,MYCN,OSR1,PBX1,PIK3R5,RGS10,TNFSF10,WNT9B | NA |
| LCK | -3.00e-01 | kinase | NA | 9.00e-02 | 1.0e-02 | CISH,EIF6,GADD45B,Gar1,IRF1,JUN,NOP58,NR1H3,POP5,SCARB1,SKP2,UTP4,XPO1 | 721 (22) |
| cyclosporin A | NA | biologic drug | NA | 9.00e-02 | 0.0e+00 | ABLIM1,ADORA1,AGT,AKR1B1,Arf2,ASNS,BAD,BCAT1,BCL2L11,Bex2/LOC100912195,CAV1,CCL5,CCND1,CD200,CD55,CD83,CD86,CDKN1A,CLDN4,Ctla2a,CXCR3,EGR2,EIF6,FDFT1,FXYD5,GJA1,GNPDA1,GTPBP4,HSPA5,ICAM1,ID3,IER3,IL19,IL20,ITGAV,JUN,KCNA5,LAMC2,LAT,MCM3,NFATC1,NOS1,OSCAR,PCNA,PDE3B,PRKACB,RBM3,REN,SERPINE1,SERPINH1,SLC23A2,SOCS1,SOX12,SREBF1,TNFSF10,TRA2A,TSPAN8,UPP1,WNT5A | 719 (18) |
| calcimycin | NA | chemical reagent | NA | 9.00e-02 | 0.0e+00 | ACE,AMD1,ATP2A2,BCL2L11,CD83,CD86,EIF6,ELN,FDX1,FOSL1,GCH1,GNRHR,HSPA5,ICAM1,ID3,JUN,LAT,PLCB3,REN,SERPINE1,TLR2,TNFSF10 | 717 (23) |
| miR-19b-3p (and other miRNAs w/seed GUGCAAA) | NA | mature microRNA | NA | 9.00e-02 | 0.0e+00 | AQP5,BCL2L11,CCND1,ESR1,NR4A2,STAT3,THBS1,TLR5 | 365 (7) |
| anti-benzo(a)pyrene-diol-epoxide | NA | chemical toxicant | NA | 8.00e-02 | 0.0e+00 | BCL2L11,CCND1,CDKN1A,GADD45B,JUN | 673 (22) |
| vadimezan | NA | chemical drug | NA | 8.00e-02 | 3.0e-02 | CCL5,CXCL10,ICAM1,IRF1 | NA |
| GRP | -7.00e-02 | growth factor | NA | 7.00e-02 | 0.0e+00 | ARF6,CCND1,CCNE1,CTRB2,IL33,JUN,MYCN,RRM2 | 686 (19) |
| IFNGR1 | 1.70e-01 | transmembrane receptor | NA | 7.00e-02 | 0.0e+00 | CA9,CCL5,CLEC7A,COMP,CXCL10,CXCR3,CYP27B1,FSCN1,GBP5,HMGA1,ICAM1,IL12RB1,IL1R2,IRF1,IRF7,MEFV,MX1,NEK3,NLRP3,NME6,PRDM5,PRIM2,TLR3,TRAF1,TRPM4,TXNDC5,UBAC1,UCP2 | 629 (17) |
| WNT5B | -1.43e+00 | other | NA | 7.00e-02 | 0.0e+00 | ATF4,CCND1,COL2A1,PROX1,RBL2,SLC7A5,VCAN | 481 (7) |
| HSF1 | 5.00e-01 | transcription regulator | NA | 6.00e-02 | 0.0e+00 | Abi3bp,AMZ1,ANXA11,ATAD2,ATG7,BMP7,C1orf226,CCNE1,COL18A1,CSRP2,DHX34,DNAJA1,DNAJB1,DNAJB6,FGF7,GREB1,HDAC5,HERC4,HSPA1A/HSPA1B,HSPB8,HSPH1,ICAM1,INHBB,JARID2,JUN,MCM3,MCM4,MLH1,MMP19,MSH3,PLIN4,PNPLA2,PRKDC,RAD51D,SERPINH1,SNCAIP,SPR,SREBF1,SYCE1,TEX15,TRPV1,Ubb,UCP3,VCAN,ZFAND2A | 679 (19) |
| BRD7 | NA | transcription regulator | NA | 6.00e-02 | 1.0e-02 | CDKN1A,ESR1,NDRG1,RAD51,SERPINE1,VCAN | NA |
| glutathione | NA | chemical - endogenous mammalian | NA | 6.00e-02 | 0.0e+00 | BCL2L11,CA9,CCND1,CDKN1A,GNL3,HSPA5,NDRG1,PCNA,SERPINE1,SLC7A11,STAT3,TH,TNC,TNFRSF10A | 684 (22) |
| VIPR1 | 8.90e-01 | G-protein coupled receptor | NA | 6.00e-02 | 4.0e-02 | CCL5,CD86,CXCL10,IRF1 | NA |
| miR-1-3p (and other miRNAs w/seed GGAAUGU) | NA | mature microRNA | NA | 6.00e-02 | 0.0e+00 | ADPGK,ANPEP,ARF4,BLCAP,CDCP1,CHSY1,CLCN3,COIL,CORO1C,CPOX,DNAJB1,ESR1,GCH1,GJA1,HDAC4,KCNJ2,LASP1,MOV10,MTHFD2,NETO2,POLA1,PTBP1,PTBP2,PXYLP1,RBM47,RFT1,TDP1,THBS1,TIMP3,WDR11,XPNPEP3 | NA |
| EZH2 | -1.91e+00 | transcription regulator | NA | 5.00e-02 | 0.0e+00 | ABL2,ACKR3,ADAM10,APPBP2,AXIN2,BCL2L11,BMP7,CABLES2,CCL5,CCND1,CCNE1,CDKN1A,CDKN1C,CNR1,CRISPLD2,CX3CL1,CXCL10,CXCL11,CXCR3,DAAM1,DUSP5,EPAS1,EZH2,FGF11,FGF13,FLT3,FZD1,ICAM1,KLF4,LAMB3,LAMC2,LYPD6B,mir-154,MLH1,NCOA7,NDRG1,NR1H4,OXTR,PARP9,PDGFB,PDGFC,POU2F3,PPP2CB,PPP2R2B,PROM1,RAD51C,RORA,SATB1,SLC7A11,SOCS1,TGFB2,TGFBR3,TIMP3,VDR,VEGFC | 663 (22) |
| MMP9 | 2.00e-02 | peptidase | NA | 5.00e-02 | 2.0e-02 | ATM,CARMIL1,CCND1,CDKN1A,COL18A1,CXCR3,GADD45A,GJA1,ICAM1,L1CAM,NFATC1,NRG1,PBX1,PRKDC,SDC1,THBS1,XRCC6 | NA |
| salmonella minnesota R595 lipopolysaccharides | NA | chemical - endogenous non-mammalian | NA | 5.00e-02 | 0.0e+00 | ATP6V1E1,BCL3,C8orf44-SGK3/SGK3,CCL5,Ccl6,CCRL2,CD83,CD86,CXCL10,FOSL1,ICAM1,IRF1,JUN,MAFF,MEFV,PDE4B,PSTPIP2,SERPINB2,SERPINE1,SLFN13,SLFN5,TLR2,TSC22D1 | 691 (20) |
| lipoxin A4 | NA | chemical - endogenous mammalian | NA | 5.00e-02 | 1.0e-02 | CCND1,CDKN1A,CFTR,ESR1,GREB1,ICAM1,IL18,NLRP3,SERPINE1 | NA |
| ruxolitinib | NA | chemical drug | NA | 5.00e-02 | 1.0e-02 | CCND1,CISH,CXCL10,ERFE,ESR1,IL18,JAK2,NLRP3,RAB20,RAD51,SOCS2,STAT2,STAT3,TYK2 | NA |
| CTNNB1 | 3.50e-01 | transcription regulator | NA | 4.00e-02 | 0.0e+00 | ABCD4,Acan,ACAT2,ACTN4,ADGRG2,ADGRV1,AQP5,ASCL2,ATM,AURKA,AXIN2,BAMBI,BCL2L11,BCS1L,BHLHE40,BMP7,CA9,CCL5,CCND1,CCNE1,CCRL2,CDKN1A,CEACAM1,CHEK2,CIDEC,CNR1,COL2A1,CX3CL1,CXCL10,Cxcl3,DIO2,EHD1,EIF5A,ENO3,EPHA5,ETV1,F2R,FGF9,FOSL1,FZD1,FZD7,GADD45B,GCH1,GJA1,GPAM,GRAMD4,GREM1,HHIP,HK2,HMGCS1,HNF1A,HOXB7,HTATIP2,ID3,ID4,IFI16,INHA,INHBB,JUN,JUP,L1CAM,LAMC2,LEF1,LGR5,MAP3K5,MMP15,MYCN,NFATC1,NPHS2,NRG1,NUMBL,OGG1,PCNA,PCSK6,PDE4B,PLIN3,PLK1,PML,PROCR,PROM1,PRSS35,RAI14,RPL3L,RPL9,RPS18,SCNN1B,SEC61A1,SERPINB2,SERPINE1,SORBS3,SOX11,SOX7,SRFBP1,STAT1,STAT2,STAT3,TELO2,TFCP2L1,TGM1,TGM2,TIMP3,TLE4,TLR3,TNC,TNFSF10,TPRA1,TRAF1,TRUB1,TSC22D1,TSPAN8,UGCG,VCAN,WNT5B | 809 (19) |
| 2’3’-cyclic guanosine monophosphate-adenosine monophosphate | NA | chemical - endogenous mammalian | NA | 4.00e-02 | 1.0e-02 | CCL5,CD86,CXCL10,IL18,IRF7,NLRP3,OAS2,SOCS1 | 477 (18) |
| darglitazone | NA | chemical drug | NA | 4.00e-02 | 1.0e-02 | ADRB3,LEP,NR1H3,UCP2 | NA |
| IRF8 | 4.00e-01 | transcription regulator | NA | 3.00e-02 | 1.0e-02 | CCL5,CD83,CD86,CDKN1A,CXCL10,EGR2,ETV6,GBP1,GNA15,ICAM1,ID3,IFI44L,IL18,IRF7,KCNJ5,KLF4,NFATC1,OAS2,Oasl2,PML,STAT1,STAT2,STX11,TK1,TLR3,TNFSF10,TRIM21 | 688 (18) |
| hydroxyurea | NA | chemical drug | NA | 3.00e-02 | 0.0e+00 | CCL5,CCND1,CCNE1,CDC25A,CDKN1A,GADD45A,GMNN,GPR50,IL20,ISG20,KLF4,LGALS12,MCM3,MX1,ORC5,PDE4A,RAD51,RRM2,STAT1,TK1,TRAF1 | 658 (20) |
| cycloheximide | NA | chemical reagent | NA | 3.00e-02 | 0.0e+00 | Acan,Akr1b7,AQP5,BAD,BRAF,CAV1,CCND1,CD55,CDKN1A,COL2A1,CXCL10,DIO2,DUSP1,EIF4E,ESR1,FDX1,GADD45A,GADD45B,GBP1,GJA1,GREB1,HMGA1,ICAM1,IL1R2,IRAK4,IRF7,ISG20,JUN,LEP,MMP19,Mt1,MYCN,NQO1,NR1H3,OLR1,PDGFB,PEX5,PLAT,PLK1,PTBP2,RBM3,SCARB1,SERPINB2,SERPINE1,SIRT4,SLC30A1,THBD,THBS1,TK1,TNFRSF10A,TNFSF10,TNIP1,Tpm4,TRA2A,TRAF1,VDR | 745 (17) |
| MBNL1 | -6.10e-01 | other | NA | 3.00e-02 | 1.0e-02 | ABLIM1,LGR5,PROM1,TGFB2 | NA |
| BCAP31 | 7.00e-02 | transporter | NA | 2.00e-02 | 2.0e-02 | CFTR,CXCL10,EGR2,HSPA5,IRF1,IRF6,NR1H3,PDGFB,SREBF1 | NA |
| IL15 | -6.70e-01 | cytokine | NA | 2.00e-02 | 0.0e+00 | ACTN4,AQP3,ATF4,ATM,BAMBI,BCL2L11,CCL5,CCND1,CD55,CD83,CD86,CDKN1A,CEACAM1,CISH,CXCL10,CYP27B1,DARS2,DPYSL5,DUSP14,DUSP5,EGR2,EIF4E,ELK3,ENO3,GNL2,GPRC5A,HK2,ID4,IFI35,IL12RB1,IL15RA,IRF1,ITGAX,JUN,Klrk1,LAT,LEF1,LEP,LSR,MX1,NFIL3,NPTX2,OAZ1,PCNA,PDE4B,PDIA4,PTP4A1,RPIA,SERPINE1,SLC16A1,SOCS1,SOCS2,TFDP2,TFRC,TLR2,TNFSF10,TXNRD1,UPP1,VDR | 756 (17) |
| LEP | 1.41e+00 | growth factor | NA | 1.00e-02 | 0.0e+00 | ACE,ACSL3,ADRB3,ANGPTL4,AQP3,ATP2A2,AXIN2,BAD,CAV1,CCL5,CCND1,CDKN1A,COL2A1,CXCL10,CYP27B1,DGAT1,EGR2,ELOVL5,ESR1,FDX1,FMO5,GADD45A,GAL,GHRL,GNRHR,GPAM,HSPA5,ICAM1,IDH1,IFT88,IL18,IL1R2,IRF1,Irgm1,ITGAX,JAK2,JUN,LEP,LIPC,MED12,MMP19,MSI1,NLRP3,NOS1,PCNA,PLAT,PNPLA2,PRDM16,PTPN1,SCARB1,Scd2,SERPINE1,SIM1,SLC13A2,SLC16A1,SMPD1,SORD,SREBF1,STAT3,TH,THBS1,TIMP3,TNFSF10,TPRA1,TRPV1,TTPA,UCP2,UCP3,USP8,VGF,WNT5A | 773 (22) |
| Pam3-Cys-Ser-Lys4 | NA | chemical reagent | NA | 0.00e+00 | 2.0e-02 | BCL2L11,BDKRB2,CCL5,CD55,CD83,CD86,CX3CL1,CXCL10,ICAM1,IER3,IFI16,IL18,IRF1,IRF7,JUN,NLRP3,PARP14,SERPINE1,SLC3A2,STAT1,TGFB2,TLR2,TLR3,TRAF1 | NA |
| ARHGAP21 | -1.30e-01 | other | NA | 0.00e+00 | 0.0e+00 | ATM,CXCL10,IL15RA,IL18,IRF1,ISG20,MERTK,PLA1A,PLAT,TLR3,TRIM21,TSC22D1 | NA |
| DSCAM | -2.70e-01 | other | NA | 0.00e+00 | 0.0e+00 | GRIN3B,ID3,JAK2,KCNJ2,KLF4,L1CAM,MAP2,MICALL2,NOS1,PDGFB,PLXNC1,PRKCB,RET,SEMA3E,SHANK2,SNCAIP,SYTL4,VGF | NA |
| IOX2 | NA | chemical reagent | NA | 0.00e+00 | 0.0e+00 | CA9,CARD11,JUN,LOX,NDRG1,P4HA1,RAB20,STC2 | NA |
| VH032 | NA | chemical reagent | NA | 0.00e+00 | 0.0e+00 | CA9,CARD11,JUN,LOX,NDRG1,P4HA1,RAB20,STC2 | NA |
| UM101 | NA | chemical drug | NA | 0.00e+00 | 0.0e+00 | CCL5,CD200,CXCL10,CXCL11,ELOVL7,GBP4,PLA1A,VDR | NA |
| JAK | NA | group | NA | 0.00e+00 | 0.0e+00 | CD83,CXCL10,FBXO32,HES6,IFIH1,IL33,SOCS1,SOCS2,STAT1,TRIM63 | 565 (17) |
| DENR | 2.10e-01 | other | NA | 0.00e+00 | 0.0e+00 | ABLIM1,JAK2,STAT1,STAT3 | NA |
| GDF9 | -7.30e-01 | growth factor | NA | 0.00e+00 | 0.0e+00 | GREM1,HAS1,ID3,INHA,INHBB,ITGAV,LOX,PCNA,VCAN | 404 (12) |
| sphingosylphosphocholine | NA | chemical - endogenous mammalian | NA | 0.00e+00 | 0.0e+00 | ICAM1,JUN,TGM1,TGM2 | 621 (18) |
| pictilisib | NA | chemical drug | NA | 0.00e+00 | 0.0e+00 | ANGPTL4,BCL2L11,TFEB,TNFSF10 | 599 (16) |
| genipin | NA | chemical - endogenous non-mammalian | NA | 0.00e+00 | 0.0e+00 | CCND1,CCNE1,CDKN1A,PCNA | 362 (7) |
| 2-oxoadipic acid | NA | chemical - endogenous mammalian | NA | 0.00e+00 | 0.0e+00 | ABCC8,GLP1R,RPH3AL,SYTL4 | NA |
| 2-aminoadipic acid | NA | chemical - endogenous mammalian | NA | 0.00e+00 | 0.0e+00 | ABCC8,GLP1R,RPH3AL,SYTL4 | NA |
| KCNJ10 | 7.00e-02 | ion channel | NA | 0.00e+00 | 1.0e-02 | CXCL10,FOSL1,GADD45A,GBP5,ICAM1,TGM1 | NA |
| KLF3 | -4.70e-01 | transcription regulator | NA | 0.00e+00 | 1.0e-02 | ADPGK,ATF4,BCL3,C11orf24,CCL24,CD55,CX3CL1,DTNB,EIF5A,EPRS1,HDAC11,HLCS,IDH1,IL18,JAK2,MAGED1,MBLAC2,MICU2,MRPL34,MSTO1,NDRG1,OGFRL1,PARP3,PATJ,PDLIM2,POP5,PPM1G,RAD51C,RASSF1,SDC1,SEC16B,SERPINH1,SLC14A1,SLC38A9,SLX4IP,TATDN2,TMPO,TNFRSF21,TNFSF10,TRIM36,UGCG,USP7,VPS16,WDR11,ZFYVE21 | NA |
| PCDH11Y | NA | other | NA | 0.00e+00 | 1.0e-02 | AXIN2,CCND1,FOSL1,GJA1,JUN,RET | 412 (7) |
| THOC5 | -2.50e-01 | other | NA | 0.00e+00 | 1.0e-02 | CPOX,DTD2,METTL21A,TMCC1 | NA |
| OSBPL8 | -7.00e-02 | transporter | NA | 0.00e+00 | 1.0e-02 | ATF4,HSPA5,LIPC,NR1H3,SREBF1 | NA |
| trabectedin | NA | chemical drug | NA | 0.00e+00 | 1.0e-02 | CCND1,CDKN1A,CXCL10,EZH2,GADD45A,MX1,TK1,WRN | 635 (14) |
| AFP | 0.00e+00 | transporter | NA | 0.00e+00 | 1.0e-02 | EGR2,GNRHR,PTP4A1,TSC22D1 | NA |
| sudemycin D6 | NA | chemical reagent | NA | 0.00e+00 | 1.0e-02 | CCL5,ICAM1,MX1,TNFSF10 | NA |
| RNASEL | -1.50e-01 | enzyme | NA | 0.00e+00 | 1.0e-02 | CDH9,CDKN1A,FZD7,IRF7,OAS2,STAT3,TIAM1,USP18 | NA |
| VCP | 3.60e-01 | enzyme | NA | 0.00e+00 | 1.0e-02 | CCL5,CDKN1A,DUSP1,HSPA5,NCL,SYNE2,TMPO | NA |
| ADCY | NA | group | NA | 0.00e+00 | 1.0e-02 | CDKN1A,GJA1,ITGA2B,LEP,NFATC1,NR4A2 | NA |
| NSUN6 | -1.02e+00 | enzyme | NA | 0.00e+00 | 2.0e-02 | FSCN1,HMMR,NDRG1,SERPINE1,TGFB2,TGM2,THBS1,TK1 | NA |
| POLR2M | -5.30e-01 | other | NA | 0.00e+00 | 2.0e-02 | CCND1,CDKN1A,EDA2R,MYOF,PHLDA3,TNFRSF10A | NA |
| BAHCC1 | -5.90e-01 | other | NA | 0.00e+00 | 2.0e-02 | CDKN1A,CDKN1C,FZD7,HOXB6,PBX1,WNT5B | NA |
| PLK2 | 1.90e-01 | kinase | NA | 0.00e+00 | 2.0e-02 | ATM,CXCL10,IL15RA,IRF1,MERTK,PLAT | NA |
| MYF6 | NA | transcription regulator | NA | 0.00e+00 | 2.0e-02 | ANGPTL4,CCL24,CDKN1A,CX3CL1,CXCL10,DLL1,ERFE,FGF7,FGF9,IL33,METRNL,PDGFB,SERPINE1,THBS1,TNFRSF10A,VEGFC | NA |
| laminaran | NA | chemical drug | NA | 0.00e+00 | 2.0e-02 | CXCL10,ELOVL7,GCH1,IFI44L,OLR1,SERPINB2,TNC,TRAF1 | NA |
| FUS | NA | transcription regulator | NA | 0.00e+00 | 2.0e-02 | ATF4,CCND1,HSPA5,ICAM1,MCM4,NCL,NDUFA5,PLK1,SLC10A4,SLC25A15 | NA |
| PLK4 | 1.40e-01 | kinase | NA | 0.00e+00 | 2.0e-02 | ATM,CXCL10,IL15RA,IRF1,MERTK,PLAT | NA |
| belnacasan | NA | chemical drug | NA | 0.00e+00 | 3.0e-02 | GSDMD,IL18,MEFV,NLRP3 | NA |
| myristoylated protein kinase A inhibitor 14-22 amide | NA | chemical - kinase inhibitor | NA | 0.00e+00 | 3.0e-02 | CCND1,GNRHR,SKP2,TH | NA |
| xanthine derivative CB002 analog 4 | NA | chemical reagent | NA | 0.00e+00 | 3.0e-02 | DPYSL5,ERCC6L,GADD45A,PHLDA3,SERPINE1,SLFN5 | NA |
| CDH11 | -2.10e-01 | other | NA | 0.00e+00 | 3.0e-02 | AGT,JUP,LAMA5,MBD2,MMP15,PRKCD | NA |
| formoterol | NA | chemical drug | NA | 0.00e+00 | 3.0e-02 | CDKN1C,CXCL10,FOSL1,PDE4D | NA |
| LLGL2 | -7.90e-01 | other | NA | 0.00e+00 | 4.0e-02 | DUSP1,FSCN1,HMMR,NDRG1,SERPINE1,TGFB2 | NA |
| CRTC1 | -1.20e-01 | transcription regulator | NA | 0.00e+00 | 4.0e-02 | NEDD9,NQO1,NR4A2,PDE10A,PDE4D | NA |
| H3-3A/H3-3B | -1.00e-01 | other | NA | 0.00e+00 | 4.0e-02 | CDKN1A,Meis1,MYCN,PROCR | NA |
| mannose | NA | chemical - endogenous mammalian | NA | 0.00e+00 | 4.0e-02 | ATF4,HSPA5,ICAM1,THBS1 | NA |
| SOCS2 | -9.70e-01 | other | NA | 0.00e+00 | 5.0e-02 | CD83,CD86,CXCL10,PIM3,STAT3 | NA |
| CHUK | 3.20e-01 | kinase | NA | -1.00e-02 | 0.0e+00 | ACKR3,CCL5,CCND1,CDC25A,CDKN1A,COL18A1,CX3CL1,CXCL10,GADD45B,GBP4,GCH1,HES6,HK2,ICAM1,IFI16,IFI35,KCNH2,Mt1,NOCT,PCNA,PLK1,PLSCR1,RABEP2,SERPINB2,TERF2IP,TIMP3,TK1,TLR3,TNIP1,VEGFC | 680 (15) |
| REL | -3.60e-01 | transcription regulator | NA | -1.00e-02 | 1.0e-02 | APLF,ATXN1,BCL3,CCND1,CD200,CD86,CDKN1A,CTU2,CXCL10,DDX11,EDARADD,EGR2,ESR1,EZH2,FBXL4,FOSL1,GADD45B,ICAM1,IER3,IL18,IRF6,JUN,JUP,NFATC1,NR4A3,PARP14,PHF14,PIBF1,SLC25A27,STAT3,TNFRSF10A,TNFSF10,TTLL1 | 604 (15) |
| SOCS3 | -1.30e-01 | phosphatase | NA | -2.00e-02 | 1.0e-02 | CCND1,CD86,CDKN1A,CXCL10,ICAM1,IGFALS,IRF1,ISG20,JAK2,JUN,LEP,MX1,OAS2,SOCS1,SREBF1,STAT3 | 702 (18) |
| CDKN1A | 9.20e-01 | kinase | NA | -2.00e-02 | 0.0e+00 | ADAM10,ATAD2,AURKA,BIRC2,CCND1,CCNE1,CDC25A,CDKN1A,CIT,CLIC4,DPP3,DUSP1,E2F4,EPS8L1,FANCG,GADD45A,HSPA1A/HSPA1B,HSPA5,ICAM1,IL18,IRF6,ITGA2,ITGAV,MAD2L1,MCM3,MCM4,MIS18BP1,MYBL2,NUSAP1,OLFML2B,OSMR,P4HA1,PARP2,PCNA,PDGFC,PLK1,POLD1,PRC1,PROM1,RAD51,RBL2,SENP2,SERPINE1,SMC2,TGM1,THBS1,TNC,TOM1L1,TSPAN1,UBE2C,XRCC6,YBX1 | 508 (14) |
| H1-2 | NA | other | NA | -2.00e-02 | 0.0e+00 | AXIN2,CCND1,CISH,GADD45A,HSPA1A/HSPA1B,IER3 | 513 (9) |
| ING1 | 9.40e-01 | transcription regulator | NA | -2.00e-02 | 0.0e+00 | ANGPTL4,CCL5,CDKN1A,DIDO1,HDAC1,HSPA1A/HSPA1B,JAK2,PPP2R1B,TPT1 | NA |
| F2R | -6.70e-01 | G-protein coupled receptor | NA | -2.00e-02 | 0.0e+00 | ANGPT1,BCL2L11,BIRC2,CCND1,CD55,DSP,DUSP1,EGR3,ESR1,F2R,GJA1,ICAM1,LAMB3,PLAT,TGFB2,TGM2,THBS1,VEGFC | 708 (18) |
| L-triiodothyronine | NA | chemical - endogenous mammalian | NA | -2.00e-02 | 3.0e-02 | ACAT2,AGT,AMD1,APOC2,ATP2A2,BAD,BCL2L11,BCL3,Ccl6,CCND1,CCNE1,CDKN1A,CHD1,CNR1,CYP27B1,CYS1,DIO2,DUSP1,DUSP5,EGR2,EPAS1,ESR1,GBP4,GHRL,GPCPD1,H6PD,HMGCS1,HSD17B7,ID3,INHA,ITGAV,Ldha/RGD1562690,LEP,LSS,MMD2,NR1D1,NR1H3,NT5E,OXTR,PARP1,PDK2,PDLIM3,POR,PRDM16,RAB30,RASD2,REN,RET,RGS9,Scd2,SERPINE1,SLC12A5,SNX29,SREBF1,TGM2,TH,TIAM1,TK1,UCP2,UCP3,VGF | NA |
| BCR-ABL1 | NA | fusion gene/product | NA | -2.00e-02 | 1.0e-02 | AURKA,BCL2L11,BLM,CAV1,CCND1,CSF2RB,EPAS1,HK2,ITGA2B,PRKCB,PRKCD,SOCS1,SOCS2,TNFRSF10A,TNFSF10 | 718 (21) |
| STAT4 | NA | transcription regulator | NA | -2.00e-02 | 0.0e+00 | ASPH,ATF4,BAD,BANP,BCL2L11,BCL3,CXCL10,DHX8,DNAJB6,EPOR,FDX1,FSCN1,FZD7,GJA1,GLG1,HES6,IER3,IFIH1,IL12RB1,IRF1,ISG20,KDELR2,MAGED1,Mt1,NDRG1,PKP2,PRDM16,RAMP2,RASSF1,RNF128,RORA,SERPINE1,STAT1,STC2,SUPT3H,TLE6 | 753 (19) |
| tamoxifen | NA | chemical drug | NA | -3.00e-02 | 0.0e+00 | ACKR3,ADORA1,ATF4,CAV1,CAV2,CCND1,CDK5RAP2,CDKN1A,CLDN4,DNAJA1,E2F4,ESR1,F2R,FADS1,FLOT1,GNRHR,GREB1,HMGCS1,HOXB7,HSPA5,IER3,IRF1,ISG20,JUN,KRT80,LOXL3,LSS,MAFF,MX1,NOP58,NOS1,NR0B2,OXTR,PCNA,RBL2,S100G,Scd2,SCUBE2,SFTPB,SFTPC,SLC7A5,SLC9A3,SREBF1,UCP2,UGCG,VDR | 804 (23) |
| PPARA | -3.60e-01 | ligand-dependent nuclear receptor | NA | -3.00e-02 | 0.0e+00 | ACAT2,ADAM10,ADRB3,AHCY,Akr1b7,ANGPTL4,APOC2,AQP3,ASNS,AURKA,CA9,CCND1,CCNE1,CDKN1A,CEACAM1,CIDEC,CTF1,CYB5B,DIO2,ELOVL5,F11R,FADS1,FDFT1,GPAM,GSTT2/GSTT2B,HMGCS1,LAMB3,LIPG,LSS,LY6D,MAD2L1,ME2,MPG,NR1D1,NR1H3,OGG1,PAH,PAQR7,PCNA,PEX11A,PLIN4,PLK1,PNPLA2,POR,PRC1,PRDM16,SCARB1,SMC2,SOCS2,SORD,SREBF1,STBD1,TFEB,TLR2,TLR5,TMTC2,UCP2,UCP3 | 540 (18) |
| KL | -2.00e-01 | enzyme | NA | -3.00e-02 | 1.0e-02 | ADAM10,ATF4,CCND1,CDKN1A,CRYAA/LOC102724652,CYP27B1,HSPA5,ICAM1,IRF7,MERTK,SCX,VDR | 754 (27) |
| SMARCB1 | NA | transcription regulator | NA | -3.00e-02 | 0.0e+00 | ATM,AURKA,BCL2L11,CCND1,CCNE1,CDKN1A,CDKN1C,CEACAM1,COL18A1,CYP39A1,Cyp3a25 (includes others),DOCK8,EIF4E,F11R,FZD7,GJA1,GMNN,IFI16,IL15RA,JUP,MCM3,MCM4,MLH1,MX1,MYBL2,PDGFB,PIWIL4,POLA1,RAD54B,SKP2,STAT3,SYCE1 | 694 (24) |
| SLC15A4 | -3.20e-01 | transporter | NA | -3.00e-02 | 0.0e+00 | ADAMTS1,ANKRD6,ASNS,BHLHA15,CCL5,CXCL10,EPSTI1,EZH2,F2R,GBP4,GBP5,HMMR,IFI16,IFI35,IRF7,ISG20,MARCKSL1,MCM3,MTHFD2,MYOF,NUSAP1,Oasl2,PRC1,RGS10,STAP2,STC2,Tpm4,TSC22D1,TSPAN8,TUBB6,TXNDC5,USP18 | 449 (17) |
| tazemetostat | NA | chemical drug | NA | -3.00e-02 | 0.0e+00 | ABCB10,ABCC4,ADAMTS1,ALS2,ATF1,BAIAP2,BCAT1,CCND1,CSE1L,DHRS3,EFNB2,EHD1,EIF4E,ESR1,FLRT3,HNRNPD,HSPA5,KLF4,L1CAM,LEF1,LGR5,LOX,LTBP1,MAP2,MICALL2,MSI1,MUTYH,NFATC1,NQO1,NR4A2,PAK1,PCNA,PDLIM5,PHF19,PTBP2,RET,RIOX2,SATB1,SLC38A1,SOX12,STAT3,STC2,STEAP2,TIAM1,TNC,USP7,VCAN,VCL,XPO1 | NA |
| PAX3 | 7.00e-02 | transcription regulator | NA | -3.00e-02 | 1.0e-02 | ASNS,CCNE1,CDKN1A,CNR1,CRY1,EGR2,FABP7,FGF9,FLT3,ID3,ID4,LAMB3,MAP2K5,MDFI,NEDD9,NMU,PCNA,PKIA,PTP4A1,RET,SHMT1,SREBF1,TGFB2,TIMP3,TNC,TSC22D1,VCAN | 468 (7) |
| CCN1 | NA | other | NA | -4.00e-02 | 0.0e+00 | BAD,BCL2L11,CCND1,CDKN1A,CXCL10,ESR1,FZD7,IL10RB,IL18,ITGA2,ITGA5,ITGAV,JUN,RBL2,SENP2,SERPINE1,TNFSF10,TOLLIP,VEGFC,WNT5A | 670 (24) |
| ARID1A | -6.00e-02 | transcription regulator | NA | -4.00e-02 | 0.0e+00 | AGL,ASCL2,ATG10,AXIN2,C8orf44-SGK3/SGK3,CA9,CCDC90B,CD83,CDKN1A,CDKN1C,CEACAM1,CKB,ESR1,F2R,FSCN1,FZD1,FZD9,GNA15,GREB1,HERC4,HIBCH,ITGA5,KLF4,L1CAM,LGR5,LSR,MYBL2,NGLY1,NRG1,NT5DC3,P3H2,P4HA1,PDK2,PDLIM5,PEX11A,PLXND1,PTGFRN,SPR,SYNE2,TNC,WNT5A,ZFPM2 | 749 (24) |
| cadmium | NA | chemical toxicant | NA | -5.00e-02 | 2.0e-02 | AGXT2,CCND1,CDKN1A,CLCN5,HSPA5,JUN,LOX,Mt1,OGG1,SLC30A1,SLC5A1,UBE2D1 | NA |
| NFIA | -1.31e+00 | transcription regulator | NA | -6.00e-02 | 4.0e-02 | ADRB3,HSD17B7,LOX,NFIA,SFTPC,TNFSF18 | NA |
| CLDN7 | 8.00e-02 | other | NA | -7.00e-02 | 0.0e+00 | ABLIM1,AGT,B4GALNT1,CX3CL1,DNAJB6,FOSL1,HELZ2,IFI44,LTA4H,MAGED1,MRPS17,MUC13,MX1,NCOA7,NETO2,NMU,NRG1,PLGRKT,SDCBP2,SLCO2A1,TINAGL1,TPK1 | NA |
| mir-223 | NA | microRNA | NA | -7.00e-02 | 0.0e+00 | AK8,ATM,CAMKK1,CARD11,CCND1,CCNE1,EGR2,EGR3,HMGCS1,ICAM1,IFI16,IL18,INPP5J,LEF1,MUC13,MYOF,NFIA,NLRP3,NQO1,PARP1,Prss34,RASGRP4,SCARB1,SERPINB2,STAT3 | 720 (23) |
| BARX2 | -3.00e-02 | transcription regulator | NA | -7.00e-02 | 2.0e-02 | ESR1,FGF12,HK2,L1CAM,TIMP3 | NA |
| TFDP1 | 1.40e-01 | transcription regulator | NA | -7.00e-02 | 3.0e-02 | ATM,CCND1,CCNE1,CDKN1A,MYBL2,MYCN,PPP1R26 | NA |
| farnesyl pyrophosphate | NA | chemical - endogenous mammalian | NA | -7.00e-02 | 4.0e-02 | ICAM1,LIPG,SCARB1,SERPINE1 | NA |
| BMP7 | 1.02e+00 | growth factor | NA | -7.00e-02 | 0.0e+00 | ADORA1,BAD,BMP7,CAV2,CDKN1A,CSRP2,DSP,DUSP1,ESR1,F11R,FGF12,FZD7,GCH1,GJA1,GRB10,GRB14,GREM1,ICAM1,ID3,ITGA5,ITGAV,KLF4,MAP3K5,Meis1,NDRG1,NUDT13,PCSK6,PENK,PKIA,PLEK2,PMEPA1,PRDM16,PRIM2,PTPN1,SERPINE1,VCAN,WNT5A,WNT5B | 652 (19) |
| MED1 | -2.00e-02 | transcription regulator | NA | -7.00e-02 | 3.0e-02 | AURKA,BCL3,BHLHE40,BOP1,CCND1,CCNE1,CDKN1A,ERMP1,GADD45A,GPAM,GREB1,KLF4,LEF1,LY6D,MAD1L1,MAD2L1,MYCN,NCL,OLR1,PEX11A,PLK1,SLC36A4,STC2,THBS1,TRPV6,UNC5D,VDR | NA |
| CD24 | NA | other | NA | -8.00e-02 | 0.0e+00 | CAV1,CDKN1A,CFTR,CHAC1,DUSP5,EPHB6,HMMR,HSPB8,ICAM1,ISG20,JMJD1C,JUN,MBNL1,NAGK,OGG1,PDGFB,PTP4A1,RBBP6,SLC30A1,SYNE2,THBS1,VDR | 612 (16) |
| CCN2 | NA | growth factor | NA | -8.00e-02 | 1.0e-02 | Acan,ADAMTS1,ADAMTS4,BIRC2,CCND1,COL2A1,ESR1,HSD17B7,JUN,LEF1,LOX,LOXL3,P4HA1,PDGFB,PTGFR,RAMP2,SERPINE1,TIMP3 | 758 (23) |
| THEM6 | -1.40e-01 | other | NA | -8.00e-02 | 2.0e-02 | ASNS,ATF4,FDFT1,HMGCS1,HSD17B7,HSPA5,PDIA4 | NA |
| EIF4EBP2 | -4.20e-01 | translation regulator | NA | -9.00e-02 | 5.0e-02 | CCL5,CXCL10,IRF7,NFIL3,PNPLA2,SERPINB2 | NA |
| p70 S6k | NA | group | NA | -9.00e-02 | 3.0e-02 | BCL2L11,CCND1,E2F4,PABPC4,PLD2,SREBF1 | NA |
| TAF4 | NA | transcription regulator | NA | -1.00e-01 | 1.0e-02 | ABL2,BRAF,CARMIL1,CCND1,GAS1,GREM1,HOPX,KLF4,MAFF,MAFK,PDGFC,PENK,Tchh,TGM1,THBS1,VEGFC | NA |
| SP2509 | NA | chemical reagent | NA | -1.00e-01 | 0.0e+00 | ABCB10,ABCC4,ADAMTS1,ALS2,ATF1,BAIAP2,BCAT1,CCL5,CCND1,CSE1L,CXCL10,DHRS3,EFNB2,EHD1,EIF4E,ESR1,FLRT3,HNRNPD,HSPA5,KLF4,L1CAM,LEF1,LOX,LTBP1,MAP2,MICALL2,MSI1,NFATC1,NQO1,NR4A2,PAK1,PCNA,PDLIM5,PHF19,PTBP2,RET,RIOX2,SATB1,SLC38A1,SOX12,STAT3,STC2,STEAP2,TIAM1,TNC,USP7,VCAN,VCL,XPO1 | NA |
| cadmium chloride | NA | chemical toxicant | NA | -1.00e-01 | 1.0e-02 | ATF4,CCL5,CCND1,DNAJB1,EIF4E,GADD45A,HK2,HSPA1A/HSPA1B,HSPA5,HSPB8,JUN,MAFF,Mt1,PCNA,PDGFB,SLC5A1 | 738 (24) |
| ETV5 | -5.60e-01 | transcription regulator | NA | -1.00e-01 | 0.0e+00 | AGER,AKAP5,AQP5,CAV1,CCL5,CCND1,CDKN1A,CHSY1,CLDN4,CLIC5,EGFL6,FXYD5,GALNT3,GCH1,HOPX,ICAM1,IRF7,ITGA5,KRT80,MID1IP1,PKP2,RET,SCARB1,SFTPB,SFTPC,TIMP3,TINAGL1 | 543 (11) |
| DICER1 | 3.10e-01 | enzyme | NA | -1.00e-01 | 1.0e-02 | ANGPTL4,ANPEP,ARID3A,AXIN2,BCL2L11,CCND1,CD86,CDKN1A,COL18A1,CXCL10,EGR2,EGR3,HDAC1,HSD17B7,ICAM1,ID3,ITGA2,ITGA5,ITGAV,ITGAX,JUN,Klrk1,LCP1,LGR5,LIPG,MAP2,mir-154,NFATC1,NPHS2,PRKCD,PROCR,PTPRN,RET,SERPINB2,SERPINE1,STAT1,TFAP4,TGFB2,THBS1,WNT5A | NA |
| oleic acid | NA | chemical - endogenous mammalian | NA | -1.10e-01 | 0.0e+00 | ANGPTL4,AQP3,ATF4,CX3CL1,DUSP1,GADD45A,GADD45B,GPAM,HK2,HSPA5,ICAM1,MAP1LC3A,Mt1,NR1H3,OLR1,PLIN3,PLIN4,PNPLA2,REN,SERPINE1,SREBF1,TLR2,UCP2,UCP3 | 695 (22) |
| GTF2IRD1 | 9.60e-01 | transcription regulator | NA | -1.10e-01 | 2.0e-02 | ARR3,ERCC5,GNAT1,GNAT2,MKX,STAT3,VSX2,ZGRF1 | NA |
| DLX1 | 4.30e-01 | transcription regulator | NA | -1.10e-01 | 3.0e-02 | BMPER,CX3CL1,FGF13,GJA1,HNF1A,NUMBL,SDC1,SERPINE1,SNTB1,VEGFC,WNT5A | NA |
| F3 | 1.40e-01 | transmembrane receptor | NA | -1.10e-01 | 3.0e-02 | ANGPT1,DUSP9,FGF13,GJA1,ICAM1,ITGA2,LCP1,LEF1,PLPP3,SERPINE1,TGM2 | NA |
| nickel | NA | chemical toxicant | NA | -1.10e-01 | 0.0e+00 | CD86,ESR1,ICAM1,JUN,Mt1,PLAT,SERPINE1,UGCG | 595 (23) |
| ESR1 | -1.02e+00 | ligand-dependent nuclear receptor | NA | -1.20e-01 | 0.0e+00 | ABCA4,ABLIM1,ACE,ACKR3,ADORA1,AFMID,AGT,AK1,AQP3,ARHGAP18,AURKA,AXIN2,BCAT1,BCL2L11,BIN1,CABP7,CAV1,CAV2,CCND1,CCNE1,CCP110,CD55,CD83,CDC42EP2,CDC42EP3,CDK5RAP2,CDKN1A,CDKN1C,CEP135,CEP70,CHEK2,CISH,CIT,CKB,CLCN3,CLDN4,CLEC7A,COG5,CPLX1,CPM,DDB2,DLG2,DLG5,DLL1,DUSP5,DUSP9,EEF2K,EFNB2,EGR3,EIF5A,ELN,ENY2,EPOR,ESR1,FGF12,FMN1,FOSL1,GADD45B,GAL,GALNT7,GEM,GJA1,GLRX,GNRHR,GPAM,GPR158,GREB1,GREM1,GRIN1,GYG1,HDAC11,HIP1R,HLA-G,HNRNPD,HSD17B7,HSPA2,HSPH1,ICAM1,IER3,IFI44,IFI44L,INHBB,INMT,IRAK2,IRF1,ISG20,ITGA2B,JAK2,JUN,KATNAL1,KCTD6,KNL1,LEP,LIPC,LTBP1,MAD2L1,MAP2,MAP2K5,MAP3K13,MAP3K14,MAP4K5,MICOS10-NBL1/NBL1,MPDZ,MX1,NEDD9,NF2,NFATC1,NQO1,NR0B2,NR1D1,NR1H3,OLR1,OXTR,PAK1,PCNA,PDE4A,PDGFD,PDLIM3,PDLIM5,PHF19,PIBF1,PKP1,POLA1,POR,PRKACB,PRKCD,PRKX,PROM1,RAD1,RAI2,RBL2,RDX,REN,RET,RGS3,RND1,RTP4,S100G,SCARB1,Scd2,SCNN1B,SCUBE2,SDCCAG8,SERPINE1,SHANK2,SKP2,SLC16A1,SLC3A2,SLC6A4,SLC7A11,SLC7A5,SLC9A3,SMC2,SMPD1,SOCS2,SORD,SP110,SPINT1,STAT1,STAT3,STC2,TFRC,TGFB2,TGM2,TH,TMPO,TNFRSF10A,TNFSF10,TNIP1,TRIB1,TYK2,UBE2I,UNC119,USP8,VDR,VEGFC,ZNF703 | 876 (20) |
| NR0B2 | -1.11e+00 | ligand-dependent nuclear receptor | NA | -1.20e-01 | 1.0e-02 | AGT,CARD11,CD86,CDKN1A,CIDEC,CXCL10,HNF1A,IL33,LY6D,mir-154,NR0B2,NR1H4,PDIA4,PIK3R5,SCARB1,SERPINE1,SREBF1,TLR2,TLR3 | NA |
| OVOL2 | -4.40e-01 | transcription regulator | NA | -1.20e-01 | 4.0e-02 | ATM,CDKN1A,CEP135,EFNB2,EPHA5,HK2,RAD51,SKP2 | NA |
| QKI | NA | other | NA | -1.20e-01 | 4.0e-02 | CAV1,CHGB,FABP7,FDFT1,GPHN,HMGCS1,HSD17B7,ITGAX,LSS,NOS1,PTPRO,Scd3,TNC | NA |
| VDR | 6.30e-01 | transcription regulator | NA | -1.30e-01 | 0.0e+00 | ACE,AGT,ATM,BMP7,CCND1,CDKN1A,CISH,CXCL10,CYP27B1,EZH2,GADD45A,HK2,ICAM1,IER3,IFI44L,IL18,JUN,LEP,MAD2L1,NEDD9,NFATC1,NR0B2,NR1H4,NUSAP1,PDLIM2,PNPLA2,PRC1,REN,S100G,SLC7A7,SOCS1,SREBF1,TGFB2,THBD,TK1,TLR2,TRPV6,UCP2,UCP3,VCL,VDR | 585 (24) |
| TLR3 | -1.60e+00 | transmembrane receptor | NA | -1.30e-01 | 0.0e+00 | ADAMTS4,CCL5,CD86,CPM,CX3CL1,CXCL10,CXCL11,DHX58,DUSP1,GADD45B,GBP4,GCH1,ICAM1,IER3,IFI16,IFI44,IFI44L,Ifi47,IFIH1,IL19,IL1R2,IL33,IRF1,IRF7,ISG20,Klrk1,LILRB4,LIPG,MX1,Oasl2,PROCR,SERPINE1,SOCS1,STAT1,TLR3,TNC,TNFSF10,USP18,ZNFX1 | 295 (14) |
| SGPP2 | -3.00e-01 | phosphatase | NA | -1.30e-01 | 2.0e-02 | ATF4,DNAJA1,HSPA14,HSPA5,HSPB8,HSPH1 | NA |
| EWSR1 | NA | other | NA | -1.30e-01 | 3.0e-02 | ACKR3,CCND1,CHEK2,GAS1,NUSAP1,RBM11,RRM2 | NA |
| ERBB2 | -1.00e-02 | kinase | NA | -1.30e-01 | 0.0e+00 | ACKR3,ADRB3,ANGPTL4,APLNR,ATF4,AURKA,AXIN2,B4GAT1,BCL3,BHLHE40,BMP7,CCL5,CCND1,CCNE1,CCRL2,CDC25A,CDC42EP2,CDC42EP3,CDCP1,CDKN1A,CIDEC,CLDN4,CNR1,CNTD1,COL18A1,CPM,CSE1L,CXCL10,CXCR3,DAAM1,DGAT1,DLL1,DNAJB6,DSP,EIF6,ELK3,EPSTI1,ESR1,ETV1,ETV6,EXT1,EXT2,F2R,F2RL3,FGF7,FGF9,FSCN1,FUT10,GALNT3,GJA1,GNPTAB,GPAM,GYG1,H6PD,HSPA1A/HSPA1B,HSPB8,ICAM1,IDH1,IRF6,ITGA2,ITGA5,JUN,JUP,KDM5B,KIFC3,KLF4,L1CAM,LAMB3,LAMC2,LSR,LSS,MAP2K3,MCM3,MCM4,MYBL2,MYCN,MYO10,NDRG1,NDST1,NEDD9,NET1,NPTX2,NR1H3,NRG1,NT5E,OPRD1,OXTR,PBX1,PCNA,PDGFD,PDIA4,PENK,PLAT,PMEPA1,POLA1,POLD1,POLE2,POLI,POLK,POMK,PPAT,PPP2R2B,PRC1,PRIM2,PRIMA1,PROM1,PTPN1,RAD51C,RBL2,RHOD,RNF149,RPA1,RRM2,SCARB1,SDC1,SEC61A1,SERPINE1,SHMT1,SKP2,SLC6A14,SLC7A5,SMC2,SOCS2,SPAG1,SPDEF,SPINT1,SSTR1,STAT3,TGM1,THBD,THBS1,TIMP3,TK1,TMEM43,TNC,TRAF1,TSC22D1,TSPAN1,UBE2C,VCAN,VCL,VDR,VEGFC,WNT5A,WNT5B,ZNF703,ZWINT | 760 (25) |
| ferric ammonium citrate | NA | chemical drug | NA | -1.40e-01 | 0.0e+00 | ELN,FTL,GADD45A,NFYA,NR4A3,TFRC | 175 (5) |
| DUSP1 | 1.10e+00 | phosphatase | NA | -1.40e-01 | 0.0e+00 | CD86,CIDEC,CLEC10A,CXCL10,DUSP1,FOSL1,HELZ2,ICAM1,IER3,IFI16,IFI44,IFIH1,IRF1,IRF7,IRF9,ISG20,JUN,MEFV,MERTK,MX1,OLR1,PAQR7,PARP1,PDGFB,PEX11A,PLAT,PNRC1,RTP4,SERPINB2,SERPINE1,SH2D2A,SOCS1,STAT2,TGFB2,THBD,TLR2,USP18,VEGFC | 706 (17) |
| JUN | -7.30e-01 | transcription regulator | NA | -1.40e-01 | 1.0e-02 | ACAT2,ASNS,BCL2L11,BCL3,BIRC2,CAV1,CCND1,CDKN1A,CRYAA/LOC102724652,CX3CL1,CXCL10,DIO2,DUSP1,DUSP5,EHD4,EIF4A1,EPAS1,FABP7,FOSL1,GADD45A,GJA1,GNRHR,GREB1,HK2,HLA-G,HMGA1,ICAM1,IFI16,ITGAV,JUN,LAMB3,LGR5,LTBP1,mir-154,MSH2,NDRG1,NFATC1,NQO1,NR0B2,OXTR,PENK,POLI,PTBP2,PTPRN,PTPRO,SDC1,SERPINB2,SERPINE1,SH2D5,STAT1,TH,THBS1,TIMP3,TK1,TNC,TNFRSF10A,VDR,VEGFC,WNT5A | NA |
| PARP14 | -1.39e+00 | enzyme | NA | -1.50e-01 | 1.0e-02 | CCL5,CCND1,CXCL10,ID3 | NA |
| 6-hydroxydopamine | NA | chemical toxicant | NA | -1.50e-01 | 2.0e-02 | ASCC1,ATF4,BAD,CABP1,CCL5,CEACAM1,CNR1,HSPA1A/HSPA1B,HSPA5,IL18,JUN,NLRP3,NR4A2,PENK,TH | NA |
| BLVRA | 7.40e-01 | enzyme | NA | -1.50e-01 | 0.0e+00 | CCL5,CXCL10,JUN,TNFSF10 | 551 (13) |
| 6-mercaptopurine | NA | chemical drug | NA | -1.50e-01 | 1.0e-02 | CXCL10,NR4A3,PCNA,TNFSF10 | NA |
| FTH1 | 3.50e-01 | enzyme | NA | -1.50e-01 | 2.0e-02 | CD86,FTL,SHMT1,TFRC | NA |
| NTF3 | 5.50e-01 | growth factor | NA | -1.50e-01 | 2.0e-02 | ETV1,GJA1,JUN,PENK,TH,TRPV1,VGF | NA |
| PDE5A | 3.00e-01 | enzyme | NA | -1.50e-01 | 3.0e-02 | ATP2A2,NOS1,PDE4A,PDE4B | NA |
| PTCH1 | 3.40e-01 | transmembrane receptor | NA | -1.50e-01 | 3.0e-02 | CCND1,COL2A1,DLL1,GADD45A,HHIP,IL33,MYCN | NA |
| Histone h3 | NA | group | NA | -1.60e-01 | 0.0e+00 | 1700056E22Rik,ACKR3,ADAM10,AQP5,ARR3,ASCL2,ATF7IP,BAHCC1,BCL2L11,BTG3,CA9,CAV1,CCL5,CCND1,CCNE1,CDKN1A,CEACAM1,CXCL10,ENO3,ESR1,EZH2,HOXB6,HSPA5,ICAM1,INHA,IRF7,ITGA5,JUN,L1CAM,LRAT,MAD1L1,MAD2L1,MAGED2,MCM3,MCM4,Meis1,MKX,Mt1,MX1,MYBL2,NDUFA5,PCNA,PDGFB,PIK3R5,PNLIPRP2,POU2F3,PPP2R2B,RASSF1,RGS10,RGS9,RRM2,SCARB1,SCNN1A,SFTPB,SLC12A5,SNUPN,SOX11,SREBF1,SYNE2,TBX6,TLR2,TNFSF10,Tpm4,TRIB1,UPP1,USP18 | 676 (20) |
| PPARD | -8.00e-02 | ligand-dependent nuclear receptor | NA | -1.60e-01 | 0.0e+00 | ADORA1,ADPGK,ANGPTL4,AQP3,CCND1,CCNE1,CLEC7A,CYB561A3,CYP39A1,ESR1,FABP7,GPAM,HHIP,HMGCS1,HSD3B7,ICAM1,IFI44L,Irgm1,LIPG,LRAT,MDFI,MERTK,MMD2,MYOM2,NR1H3,NR1H4,NR4A2,NR4A3,OLR1,PCNA,PCSK6,PLAT,PNPLA2,RORA,SCARB1,SFI1,SORD,SREBF1,ST3GAL5,STAT1,STBD1,THBS1,Tlr12,TLR5,TMEM120A,TRIM63,UCP2,UCP3,USP38 | 675 (20) |
| CD38 | 3.10e-01 | enzyme | NA | -1.60e-01 | 0.0e+00 | ASNS,B4GALT7,CCNE1,CD86,CISH,CLCN3,CSF2RB,GBP4,GPAM,GSTT2/GSTT2B,HMMR,ICAM1,IL1R2,NDRG1,NFIL3,NT5E,P4HA1,PPP3CC,SAP30,Scd2,SDC1,SEMA4A,SLAIN1,SLC7A5,SLFNL1,SOCS1,SOCS2 | 719 (22) |
| MEOX2 | 1.70e-01 | transcription regulator | NA | -1.60e-01 | 0.0e+00 | ANGPT1,CDKN1A,CDKN1C,ICAM1,ID3,ID4,ITGAV,PCNA,TRAF1,VEGFC | 440 (10) |
| calcipotriene | NA | chemical drug | NA | -1.60e-01 | 1.0e-02 | FOSL1,IL19,IL20,IL33,JUN,PRKCD,SERPINE1 | NA |
| NFKB1 | -4.80e-01 | transcription regulator | NA | -1.60e-01 | 0.0e+00 | ADORA1,AKR1B1,BAMBI,BCL3,BHLHE40,CCL5,CCND1,CD83,CD86,CDKN1A,CFTR,COL2A1,CX3CL1,CXCL10,CXCL11,DUSP1,EPAS1,FSCN1,GADD45A,GBP1,GFRA1,GJA1,ICAM1,IER3,IFI16,IL18,IL20,IRF1,LAMB3,NFATC1,NFKBIB,NR4A2,NR4A3,ORAI1,PRKCD,STAT1,TK1,TLR2,TNFSF10,TRAF1,VEGFC | 715 (13) |
| PSEN1 | 1.30e-01 | peptidase | NA | -1.70e-01 | 2.0e-02 | ACTG1,AGER,ARF4,ARF6,ATP2A2,ATP4A,ATP6V1E1,CALML3,Casp12,CCL5,CCND1,CKB,DLL1,DLL3,DNAJC5,DUSP1,ELOVL4,ERMP1,F2R,Fus,GADD45B,GJA1,GRIN1,HSPA5,IDE,IRF7,L1CAM,MAP2,MAP6,MERTK,MTHFD1L,NDUFA5,NOS1,PAK1,PRC1,RBM3,SCARB1,SOCS1,SYT13,TH,TPT1,TUBA1C,TUBB2A,TUBB4B,TUBB6,UEVLD | NA |
| oblimersen | NA | biologic drug | NA | -1.80e-01 | 0.0e+00 | CDKN1A,DUSP1,EFNB2,GADD45A,GADD45B,IFI16,IFI35,IFI44,IRF7,MAFF,MX1,OAS2,STAT1 | NA |
| fluoride | NA | chemical - endogenous mammalian | NA | -1.80e-01 | 2.0e-02 | ACTN4,CALML3,DDX39A,EZH2,GADD45A,HSPA1A/HSPA1B,HSPA2,HSPA5,PLD2,TUBB2A,TUBB4B,TUBB6,Ubb | NA |
| entinostat | NA | chemical drug | NA | -1.80e-01 | 0.0e+00 | ASCL2,BAD,BCL2L11,CCND1,CCNE1,CD83,CDKN1A,CXCL10,DUSP1,ITGAX,LGR5,PCNA,SERPINE1,TNFRSF10A,TNFSF10,VDR | 741 (22) |
| UBA1 | 2.00e-02 | enzyme | NA | -1.90e-01 | 1.0e-02 | ATF4,BIRC2,CCND1,HSPA5,NOS1,TUBA1C | NA |
| MAP3K1 | NA | kinase | NA | -1.90e-01 | 1.0e-02 | BIRC2,CCND1,DUSP1,JUN,LOXL3,RGS7,SERPINE1,THBS1,TNC,TNFRSF10A | NA |
| RARA | 2.60e-01 | ligand-dependent nuclear receptor | NA | -1.90e-01 | 0.0e+00 | ABLIM1,ADAM10,CCND1,CDKN1A,DHRS3,DUSP1,EGR2,EGR3,ENOX1,ENY2,FGF12,GPR158,GREB1,HLA-G,HNRNPD,HOXB7,IDE,IFI44,IFI44L,IL12RB1,IRF1,IRF6,JUN,JUP,KLF4,KNL1,MAD2L1,Meis1,MYCN,NEDD9,PENK,PHF19,RASGRP4,RET,RGS3,RILP,RTP4,SFTPB,SHANK2,SLC7A11,SMPD1,SP110,STAT1,TH,THBD,TLE4,TNFRSF10A,UCP3,ZNF703 | 764 (25) |
| 27-hydroxycholesterol | NA | chemical - endogenous mammalian | NA | -1.90e-01 | 1.0e-02 | ACE,AGT,ANPEP,LEP,REN,SREBF1 | 826 (18) |
| rifampin | NA | chemical drug | NA | -1.90e-01 | 1.0e-02 | ABCB10,AXIN2,CARS1,CEP135,CEP70,CXCL10,ECT2,FMO4,FMO5,GPRC5B,HMMR,NAGK,NR0B2,RGS10,SLC39A10,TBC1D9,TGIF2,TLR2,TMPRSS4,TWF2,UGT1A4,USP18 | NA |
| olanzapine | NA | chemical drug | NA | -2.00e-01 | 0.0e+00 | CTRB2,GRIN3B,HDAC5,HLA-G,HMGCS1,LRAT,NAALADL1,NR4A2,NR4A3,NRG1,S100G,SCNN1A,SLC25A27,SLC38A1,THBD,TRIM17,TSPAN8,Vmn2r1 | NA |
| EIF2AK2 | -2.90e-01 | kinase | NA | -2.00e-01 | 3.0e-02 | ATF4,BHLHE40,BIRC2,CCND1,CDKN1A,IFI35,IRF1,ISG20,JUN,NEDD9,PARP9,PLSCR1,REC8,STAT1,USP18 | NA |
| ILKAP | -8.00e-02 | phosphatase | NA | -2.00e-01 | 3.0e-02 | CCND1,CD86,HK2,NDRG1,NR4A3 | NA |
| EWSR1-FLI1 | NA | fusion gene/product | NA | -2.00e-01 | 4.0e-02 | CAV1,CCND1,CDKN1A,EGR3,F11R,FJX1,KAZN,MAP2,PMEPA1,PTPRO,SERPINE1,SLFN5,THBS1 | NA |
| P38 MAPK | NA | group | NA | -2.10e-01 | 0.0e+00 | AGER,ANGPT1,AQP5,ATG7,CAV1,CCL24,CCL5,CCND1,CCNE1,CCNF,CD55,CD83,CD86,CDKN1A,CXCL10,CXCL11,DDB2,DIO2,DUSP1,EGR2,FBXO32,GBP1,GJA1,HSPA5,ICAM1,ID3,IER3,IRF6,IRF7,ITGAV,JUN,KLF4,LEP,MSH2,NFATC1,NR1H4,NR4A3,PCNA,PML,RAB7B,RAD51,SCNN1A,SERPINB2,SERPINE1,STAT1,TH,THBS1,TIMP3,TLR2,TNFSF10,TNIP1,TRADD,TRIB1,VDR,VEGFC,WNT5A | 788 (19) |
| SQSTM1 | 1.10e-01 | transcription regulator | NA | -2.10e-01 | 0.0e+00 | ATM,CXCL10,IL15RA,IL18,IRF1,JUN,LEP,MAP1LC3A,NQO1,PLAT,TSC22D1 | 530 (18) |
| GLI1 | -3.00e-01 | transcription regulator | NA | -2.20e-01 | 0.0e+00 | AQP5,ATAD2,BCL2L11,CAPRIN2,CAV1,CAV2,CCND1,CDK19,CDKN1A,CEP70,CLIC5,CNIH4,CNTRL,COL2A1,DIO2,DUSP5,EGR3,EPHB6,EXT2,FAM110C,FLT3,GADD45B,GPRC5A,GRIA3,HHIP,HIVEP2,ID3,IER3,IL18,IL1R2,IL20,IL33,IRF2BPL,JUP,KCNJ8,KDM5B,KLF4,KNL1,KRT80,LAMB3,LRRC1,MAFF,MCM4,METTL21A,MICAL2,MLH1,MSI2,MYCN,NAV3,NRG1,OGFRL1,PAH,PDZRN3,PPIF,PSTPIP2,PTGDR2,RGS10,SCLY,SEC61A1,SKP2,SOCS1,SOCS2,STRADB,TGFB2,TGFBR3,TIMP3,TNC,TOX2,TPK1,TRIM15,TSC22D1,TSPAN1,USP7,VEGFC,VIL1,WNT5A,ZMIZ1 | 649 (18) |
| L-serine | NA | chemical - endogenous mammalian | NA | -2.20e-01 | 0.0e+00 | ATF4,CCND1,CCNE1,CDKN1A,PCNA | 566 (12) |
| IGFBP2 | 5.10e-01 | other | NA | -2.20e-01 | 5.0e-02 | Acan,CCND1,ESR1,ITGA5,LGR5,NEDD9,NMU,PTGFRN,STAT3 | NA |
| G protein alpha i | NA | group | NA | -2.20e-01 | 0.0e+00 | ADAMTS1,CXCL10,F2R,FOSL1,GBP4,GBP5,GEM,IFIH1,Igtp,Irgm1,KLF4,MAFF,NR4A3,Oasl2,RAB20,TGM1,THBS1,TUBB6,USP18 | 593 (14) |
| KDM4A | -2.10e-01 | transcription regulator | NA | -2.20e-01 | 0.0e+00 | ALS2,CCND1,CDKN1A,CXCL10,CXCL11,MIS18BP1,PIM3 | 334 (16) |
| TXNIP | -2.10e-01 | other | NA | -2.20e-01 | 3.0e-02 | AGER,CCND1,CDKN1A,GSDMD,ICAM1,IDH1,IL18,NLRP3,NPHS2,PCNA | NA |
| KDM2B | 4.00e-02 | enzyme | NA | -2.30e-01 | 1.0e-02 | CCL5,CDKN1A,COL2A1,CX3CL1,CXCL10,EZH2,LAMA5,SOX7 | NA |
| CDK6 | 2.80e-01 | kinase | NA | -2.30e-01 | 0.0e+00 | AGT,APBB2,CA9,DSP,FGF11,GADD45A,HNRNPD,INPP5J,ITGA11,ITGA2,JUN,MICOS10-NBL1/NBL1,MLH1,PPP1R3B,PRKACB,PRKCB,RBL2,SERPINE1,SOCS1 | 643 (24) |
| FCGR2A | NA | transmembrane receptor | NA | -2.30e-01 | 1.0e-02 | CCL5,CXCL10,ICAM1,IL18,IRF7,ISG20,MARCKSL1,Oas1b,SERPINE1,STAT1,USP18 | 675 (18) |
| torkinib | NA | chemical drug | NA | -2.40e-01 | 0.0e+00 | ADAMTS1,AURKA,BLM,CCND1,CCNF,CDC25A,DEPTOR,EGR2,FOSL1,GJA1,GMNN,ID3,ITGA2,KDM5B,KIF18B,KLC4,KNL1,MAP2K3,MCM3,MTHFD2,NR4A2,NR4A3,PARP1,PCNA,PDLIM2,PMEPA1,PML,POLE2,PPIF,RAD51,RAD54B,RPA1,S100G,SKP2,SMC2,TK1,TMEM119 | 680 (20) |
| ID3 | -9.00e-01 | transcription regulator | NA | -2.40e-01 | 0.0e+00 | ASCL2,BCL2L11,BCL3,BMP7,CCL5,CCNE1,CD83,CDKN1A,CSF2RB,CXCR3,DUSP1,DUSP22,EGR2,GADD45B,GNL3,ICAM1,ID3,IFI16,INHBB,IRF6,JAK2,MAP3K14,NFATC1,NR4A3,PAWR,PIK3R5,PPAN,RAPGEF4,RORA,SDC1,TGFBR3,TNFSF10,TOX2,TRAF1 | 552 (17) |
| SOX3 | NA | transcription regulator | NA | -2.40e-01 | 0.0e+00 | ANGPT1,BMPER,DLL1,DSP,DUSP1,DUSP5,EXT2,FARP1,GBP4,GREB1,KIF16B,Oasl2,RET,TGFB2,TXNRD1,USP18,WNT5A | NA |
| mannitol | NA | chemical - endogenous mammalian | NA | -2.40e-01 | 1.0e-02 | AKR1B1,BCL2L11,ICAM1,JUN,MPDZ | NA |
| AZGP1 | -4.10e-01 | transporter | NA | -2.40e-01 | 0.0e+00 | CCND1,DSP,FBXO32,HK2,ITGA5,PNPLA2,TRIM63,UCP3 | 554 (11) |
| lapatinib | NA | chemical drug | NA | -2.50e-01 | 5.0e-02 | BCL2L11,ESR1,FOSL1,ITGA2,JUN,LAMB3,SOX8 | NA |
| HRAS | 1.10e-01 | enzyme | NA | -2.50e-01 | 0.0e+00 | Acan,ACTG1,ARF6,ASNS,ATP2A2,ATXN1,AURKA,BCL2L11,BMP7,CAV1,CCL5,CCND1,CCNE1,CDC25A,CDK18,CDKN1A,CGREF1,CISH,COL18A1,COL2A1,CSRP2,CXCL10,CXCL11,CXCR3,DLL1,DUSP1,DUSP9,EIF3C,ELK3,ELN,ETV1,F2R,FDFT1,FOSL1,FRMD6,FUT7,FZD1,GFER,GJA1,HOXB6,ICAM1,ITGA5,ITGAV,JUN,JUP,LASP1,LIPG,MGME1,MTHFD1L,MUC13,MYCN,NOP58,NQO1,NSFL1C,PABPC4,PAWR,PCNA,PDGFC,PDLIM5,PKP1,PLK1,PMEPA1,PML,PRKCB,PRKCD,PTGFRN,RAD9A,RRM2,Scd2,SCNN1A,SERPINB2,SERPINE1,SKAP2,SLC1A7,SMARCA2,SOCS2,SREBF1,TGFB2,TGM2,THBS1,TIMP3,TINAGL1,TK1,TNFRSF10A,TOX2,Tpm4,TRPV1,TSC22D1,ULK2,VCAN,VCL | 715 (22) |
| docetaxel | NA | chemical drug | NA | -2.60e-01 | 2.0e-02 | AURKA,BIRC2,CCL5,CDKN1A,CHEK2,CXCL10,CXCL11,ITGA2,ITGAV,MAD2L1,MCM4,PCNA,TGFB2,THBS1,TNFRSF10A,TNFSF10,TUBB4B,TUBB6,UGCG | NA |
| EHMT1 | 2.70e-01 | transcription regulator | NA | -2.60e-01 | 0.0e+00 | ANPEP,CDKN1A,CDKN1C,GFOD1,GRAMD4,GTF2IRD1,MEGF9,MLH1,PCSK6,PKP2,POR,RAB11FIP3,SCNN1A,SHMT1,SLC7A7,SYCE1,TDRKH,TLE2,UNC13B | NA |
| PPARGC1A | 2.00e-01 | transcription regulator | NA | -2.60e-01 | 0.0e+00 | ADAMTS1,AGT,AK1,APEX2,APOC2,ARR3,BLM,BMPER,CDKN1A,COL2A1,COMP,CPLX1,CXCL10,DGAT1,DIO2,EGFL6,EMILIN2,EPAS1,FANCG,FBXO32,GADD45B,GFRA1,GJC2,GPAM,GRIN2C,GUCY2F,HK2,ICAM1,IL18,IL1R2,IMPA1,INHA,INHBB,INPP5J,JAK2,LIPC,MCM3,MCM4,MMP15,MMP19,MSI1,NR1H3,NR1H4,OLR1,OSMR,PDE6D,PDK2,PNPLA2,SCARB1,SERPINH1,SOCS1,SREBF1,STAT1,STAT3,TGFBR3,TIMP3,TNFSF10,TRADD,TRIM63,UCP2,UCP3,VCAN | 556 (18) |
| etoposide | NA | chemical drug | NA | -2.60e-01 | 0.0e+00 | ADAM10,BCL2L11,BIN1,BIRC2,BLM,CCL5,CCND1,CCRL2,CD86,CDC25A,CDKN1A,CSF2RB,CXCL10,CXCL11,DUSP1,EPSTI1,FANCG,GADD45A,HK2,ICAM1,IER3,IFI44L,IRF1,IRF7,JAK2,JUN,MERTK,OAS2,PCNA,PDE4B,RAD9A,SENP2,STAT1,TAF6,TK1,TNFRSF10A,TNFSF10,TRADD,WRN | 612 (16) |
| FBXO32 | 1.47e+00 | enzyme | NA | -2.60e-01 | 2.0e-02 | ABCC4,AXIN2,BCL2L11,BHLHA15,CSRP2,Cxcl3,FGF9,GADD45A,HOOK1,HSPA5,LEF1,MYCN,SERPINB2 | NA |
| D-glucose | NA | chemical - endogenous mammalian | NA | -2.70e-01 | 0.0e+00 | Acan,ACE,AGER,AGT,AKR1B1,ARF4,ASNS,ATF4,ATG7,ATP2A2,ATP2B2,BAD,BCAT1,BCL2L11,C8orf44-SGK3/SGK3,CARS1,Casp12,CAV1,CCND1,CCNE1,CD55,CDKN1A,CNR1,COL2A1,CX3CL1,DUSP1,EIF5A,ERFE,EVA1A,FBXO32,GAS1,GCH1,GHRL,GIPR,GJA1,GLP1R,GPAM,GREM1,GSDMD,H6PD,HDAC1,HK2,HSPA5,ICAM1,IDH1,IL18,INHBB,ITGA5,JUN,KAT2B,KDELR2,LCP1,Ldha/RGD1562690,LEP,MAP1LC3A,MID1IP1,mir-154,Mt1,NLRP3,NPHS2,NQO1,NR1H4,NR4A2,NR4A3,PARP1,PCNA,PDIA4,PLIN3,PPP2R2B,PRKCB,PRKCD,PTPRN,REN,RRM2,S100G,Scd2,SCUBE3,SEC61A1,SEPHS2,SERPINB2,SERPINE1,SIRT4,SLC39A7,SLC3A2,SLC5A1,SREBF1,SYTL4,TAS1R3,TFRC,TGM2,THBS1,TK1,TLR2,TRIM63,TRPV6,TXNRD1,UCP2,UCP3,VCAN,VCL,VIL1,WIPI2,YBX1 | 786 (19) |
| PF4 | -1.90e-01 | cytokine | NA | -2.70e-01 | 0.0e+00 | CD83,CD86,CDKN1A,CPM,E2F4,EPSTI1,GCH1,HNF1A,ICAM1,IL19,IRF1,KLF4,MYCN,STAT1,STAT2,THBD,USP18,VDR | 729 (20) |
| SRF | 2.60e-01 | transcription regulator | NA | -2.70e-01 | 0.0e+00 | ABCA4,ACTG1,AMD1,ANKRD6,BCL2L11,CCL5,CDH9,CDKN1A,CLDN15,CPM,CSRP2,DUSP5,EGR2,EGR3,EIF6,EPG5,ETV1,FGF12,FOSL1,GADD45A,GCH1,GPATCH4,HEATR5B,HES6,ITGA2B,JUN,KDSR,MAP3K14,MBD2,MPPED2,NCOA7,NECTIN1,NET1,NPTX2,NR4A2,ODF2L,Prss34,RAI2,RBBP6,SERPINB2,SLC6A4,TMEM44,TNC,Tpm4,TUBB4B,TUBB6,VCAN,VCL | 683 (18) |
| dopamine | NA | chemical - endogenous mammalian | NA | -2.80e-01 | 2.0e-02 | BAD,CCL5,CLCN3,CNR1,CXCL10,EGR3,GIPR,GPR83,GPRC5B,GRIN1,HAS1,IFI16,JUN,KLF4,MAP2,NFATC1,NMU,NR4A3,PDE10A,PDE1B,PENK,RNLS,TH,TRPV1 | NA |
| LCAT | -1.60e-01 | enzyme | NA | -2.80e-01 | 5.0e-02 | AXIN2,CCND1,HSPA5,SCARB1,UCP3 | NA |
| bile acid | NA | chemical - endogenous mammalian | NA | -2.80e-01 | 1.0e-02 | APOC2,CAV1,DIO2,NR0B2,NR1H4,SLC23A2,SPINT1,UCP3 | 539 (13) |
| androgen | NA | chemical drug | NA | -2.80e-01 | 3.0e-02 | ADAMTS15,ARHGEF26,AXIN2,CCND1,FGF7,FOSL1,GJA1,JUN,Mt1,PRKCB,PTPN1,RET,SDC1,SKP2,SOCS1,STAT3,TPT1,TRADD,VEGFC,VIL1,WNT5A,YBX1 | NA |
| mir-29 | NA | microRNA | NA | -2.90e-01 | 1.0e-02 | ANGPTL4,BDKRB2,CCND1,ELN,FLT3,HMGA1,ITGA11,KLF4,LEP,MYBL2,MYCN,NAV3,OLR1,PDGFC,SCARB1,THBS1,TIMP3 | 821 (25) |
| bisphenol A | NA | chemical - endogenous mammalian | NA | -2.90e-01 | 0.0e+00 | AQP5,CCND1,CCNE1,CDKN1A,CXCL10,ELN,ESR1,F11R,FGF7,FGF9,GNRHR,HSPA1A/HSPA1B,LEP,NMD3,NR4A2,NR4A3,PCNA,PPP1R10,RBM47,RPH3A,RPL9,S100G,SCNN1G,SKIL,SLC12A5,SLC6A14,SLC6A4,SRD5A1,STAT3,TGM2,THBS1,TIMP3,TNC,TRA2A,TWF2,VCAN | 902 (24) |
| TRIB3 | 3.00e-02 | kinase | NA | -2.90e-01 | 3.0e-02 | ASNS,BCL2L11,CDC25A,FBXO32,HK2,MTHFD2,STC2 | NA |
| potassium chloride | NA | chemical drug | NA | -3.00e-01 | 1.0e-02 | ATP2B2,BCL2L11,CCNE1,EGR2,FGF9,HSPA5,ID3,JUN,NOS1,NR4A2,NR4A3,PDIA4,PIM3,S100G,SCNN1A,TH,TRPV6 | NA |
| PRKCB | -7.80e-01 | kinase | NA | -3.00e-01 | 1.0e-02 | ADRB3,CCND1,CD83,CD86,CDKN1A,ICAM1,JUN,NR0B2,PRKCB,PRKCD,SERPINE1,SREBF1 | NA |
| Insulin | NA | group | NA | -3.00e-01 | 0.0e+00 | ABCC8,ADAM10,ADRB3,AGT,ANGPTL4,APLNR,ATG7,BAD,CAV2,CCL5,CCND1,CCNE1,CDKN1A,CHRM1,CIDEC,COL18A1,DUSP1,E2F4,EGR2,EPAS1,FADS1,FBXO32,FDFT1,FTL,GHRL,GRB10,GRB14,GREB1,HK2,HMGCS1,HNF1A,HSPA5,ICAM1,IDE,IDH1,IGFALS,IL18,IRF7,JAK2,JUN,KLF4,LEP,LGALS12,Mt1,NFIL3,NLRP3,NOS1,NR1H3,NR1H4,NR4A2,NR4A3,PCNA,PDK2,PLAT,PLIN3,PNPLA2,PRKCB,PRKCD,PTGFRN,PTPRN,RBL2,REN,RRM2,SCARB1,Scd2,SERPINE1,SFTPB,SKP2,SLC25A27,SLC2A5,SLC31A1,SLC6A4,SOCS2,SRD5A1,SREBF1,STAT1,STAT2,STAT3,THBS1,TIMP3,TLR2,TNC,TRIM63,TRPV1,TTF2,UCP2,VGF | 748 (24) |
| S1PR2 | -5.50e-01 | G-protein coupled receptor | NA | -3.00e-01 | 2.0e-02 | CCL5,ICAM1,JUN,PCNA,PDGFB | NA |
| DDIT4 | -2.40e-01 | other | NA | -3.00e-01 | 3.0e-02 | CCL5,CXCL10,CXCR3,ICAM1,IL33,NLRP3,SREBF1 | NA |
| BRCA1 | -3.90e-01 | transcription regulator | NA | -3.00e-01 | 0.0e+00 | AK1,ANGPT1,AQP5,ASCL2,ATM,CCL5,CCND1,CCNE1,CDKN1A,COL18A1,DDB2,ERCC5,ESR1,GADD45A,GADD45B,HNRNPD,IRF7,MAD2L1,MATN4,MLH1,MX1,NEDD9,NQO1,PARP1,PCNA,PLK1,PLSCR1,RAD51,RBL2,STAT1,UBE2I,VCAN,XRCC6 | 625 (23) |
| S-nitrosoglutathione | NA | chemical toxicant | NA | -3.10e-01 | 1.0e-02 | BIRC2,CCL5,CD86,CDKN1A,CNR1,CXCL10,GJA1,ICAM1,NQO1 | 679 (23) |
| citric acid | NA | chemical - endogenous mammalian | NA | -3.10e-01 | 3.0e-02 | GSDMD,IL18,NLRP3,PRKCB | NA |
| TLR9 | 7.30e-01 | transmembrane receptor | NA | -3.10e-01 | 0.0e+00 | ADAMTS4,CCL5,CCND1,CD83,CD86,CISH,CPM,CXCL10,DUSP1,GADD45B,GCH1,ICAM1,IER3,IFI16,IFI35,IFI44L,IL18,IL19,IL33,IRAK4,IRF1,IRF7,IRF9,ISG20,LILRB4,LIPG,MX1,NR0B2,NR1H4,OAS2,Oasl2,PROCR,RAB7B,SDC1,SERPINE1,SGMS2,SMPD1,SOCS1,ST3GAL5,STAT1,STAT2,TNC,TNFSF10,UGCG,USP18 | 502 (16) |
| 3-aminobenzamide | NA | chemical toxicant | NA | -3.20e-01 | 3.0e-02 | CDKN1A,ICAM1,NCL,PARP1,PCNA | NA |
| NVP-TAE684 | NA | chemical drug | NA | -3.20e-01 | 1.0e-02 | BCL2L11,CCND1,CDC25A,CDKN1C,PTP4A1,RET,SERPINE1,VCAN | NA |
| Tnf (family) | NA | group | NA | -3.30e-01 | 1.0e-02 | BIRC2,CCL5,CCND1,CCRL2,CD86,CLDN4,CSTB,CX3CL1,CXCL10,CXCL11,FBXO32,GJA1,ICAM1,IL1R2,IL33,IRAK2,JUN,NT5E,PCNA,PDGFB,PLEK2,SERPINE1,TGM2,TLR2,TNIP1,TRAF1,TRIM63 | NA |
| IFNE | NA | cytokine | NA | -3.30e-01 | 0.0e+00 | CD83,CD86,CDKN1A,CXCL10,CXCL11,EIF4E,IFIH1,ISG20,STAT1,TLR3,USP18 | 263 (13) |
| RORA | 1.67e+00 | ligand-dependent nuclear receptor | NA | -3.40e-01 | 0.0e+00 | ASNS,B3GALT1,CCL24,CCL5,CCNE1,CDC25A,CDKN1A,CISH,CXCL10,CYP39A1,Cyp3a25 (includes others),ELOVL7,FDFT1,GADD45A,GADD45B,HSD17B7,IL18,KCNK5,Mt1,NAT2,NOCT,NR1D1,POLE2,POR,RAD51,RORA,Scd2,SLC13A2,Slco1a4,SREBF1,Sult1d1,TLR3,UCP2,UCP3 | 529 (15) |
| CDK19 | -8.90e-01 | kinase | NA | -3.40e-01 | 0.0e+00 | ANKRA2,BAIAP2,CDKN1A,CGRRF1,DDB2,FDFT1,GADD45A,HMGCS1,JUN,KLF4,LSS,PHLDA3,PROCR,RAD9A,SDC1,SEC61A1,SLC7A11,TFCP2L1,TSC22D1,UPP1,VDR | NA |
| TRAPPC1 | 1.70e-01 | other | NA | -3.40e-01 | 1.0e-02 | ATF4,Casp12,CDKN1A,DNAJA1,EDEM2,HSPA1A/HSPA1B,HSPA2,HSPA5,MAN1B1,MAP3K5,NSFL1C,PDIA4,RAD23B,SEC61A1,UBE2G1 | 360 (7) |
| E2F1 | 7.00e-02 | transcription regulator | NA | -3.40e-01 | 0.0e+00 | Acan,ATAD2,ATG7,ATM,AURKA,BAD,BCL2L11,BCS1L,CAV1,CCND1,CCNE1,CCNF,CDC25A,CDKN1A,CDKN1C,CHEK2,CKB,COL2A1,CSE1L,CYP27B1,DDB2,DDX11,DUSP1,E2F4,ECT2,EGR2,EZH2,FHDC1,GLP1R,GMNN,GRAMD4,HLTF,HMGA1,HNRNPD,ICAM1,ID3,INMT,KCNH1,LEP,LTA4H,MAD2L1,MAP3K14,MAP3K5,MCM3,MCM4,MLH1,MSH2,MTHFD1,MYBL2,MYCN,Myh9,NCL,NFKBIB,NR4A3,NUSAP1,PAWR,PCNA,POLA1,POLD1,PPM1G,PPP1R26,PRIM2,PRKDC,RAD51,RAD52,RAD54L,RRM2,RRP1B,SERPINE1,SLC16A1,SLC3A2,SLC7A11,SOX7,TGM1,THBS1,TK1,TXNRD1,UCP2,ULK2,VRK1 | 493 (15) |
| ZMPSTE24 | -1.70e-01 | peptidase | NA | -3.40e-01 | 0.0e+00 | Ccl6,CDKN1A,CISH,GADD45A,GADD45B,ICAM1,IGFALS,JAK2,NLRP3,SOCS1,SOCS2 | 717 (23) |
| ALOX15 | 8.00e-02 | enzyme | NA | -3.50e-01 | 5.0e-02 | AXIN2,CXCR3,FOSL1,ICAM1,ID3,JUN,Muc1 | NA |
| testosterone | NA | chemical - endogenous mammalian | NA | -3.60e-01 | 0.0e+00 | AGER,Akr1b7,AMD1,ANGPT1,ANPEP,ATP2A2,BCL3,BMP7,CAV1,CCND1,CCNE1,CDKN1A,CLCN3,ESR1,FBXO32,FGF7,FOSL1,GADD45A,GNRHR,GUCY1A2,HCRTR1,HCRTR2,HSPA1A/HSPA1B,HSPA5,ID3,IL33,INHBB,JAK2,JUN,LEP,Mt1,MX1,NDRG1,NOS1,PARP1,PCNA,PDE3B,PDIA4,PRKCB,PTP4A1,RAI14,REN,Scd3,SCNN1A,SDC1,SRD5A1,SSTR1,STAT3,STEAP2,TGFB2,THBS1,TK1,TRIM63,TUBB2A,TXNRD1,TYK2,VCAN,WNT5A | 907 (20) |
| azoxymethane | NA | chemical toxicant | NA | -3.60e-01 | 0.0e+00 | ACE,AGT,ATM,BLM,CCND1,CDKN1A,CXCL10,DCLRE1A,IL18,MLH1,MSH2,MSH3,PARP1,PARP2,PCNA,PRKCB,PRKCD,REN,STAT3 | 617 (20) |
| PSMB11 | 3.20e-01 | peptidase | NA | -3.70e-01 | 0.0e+00 | Abi3bp,CAV1,CCL5,CCND1,CLDN4,CYB5B,GADD45A,GADD45B,HSPA1A/HSPA1B,L1CAM,NR4A2,OLFML2B,PIK3R5,PRKCB,RELT,TGFB2,THBS1,TNFRSF21,TNFSF10,TRAF1,VCAN,VEGFC | 418 (7) |
| glycine | NA | chemical - endogenous mammalian | NA | -3.70e-01 | 1.0e-02 | ASNS,ATF4,CCND1,CCNE1,CDKN1A,PCNA | 668 (18) |
| MITF | -4.50e-01 | transcription regulator | NA | -3.70e-01 | 1.0e-02 | APEX2,C8orf44-SGK3/SGK3,CCNF,CDKN1A,CHTF18,COL2A1,ECT2,EME1,FANCG,FBXO32,GMPR,GNPTAB,GREB1,HMBS,INPP4B,KAZN,MCM4,OSCAR,PLA1A,PLK1,POLD1,POLE2,POLM,RAD51D,SCARB1,SDC1,SERPINE1,SLC14A1,STX7,TFEB,TPSAB1/TPSB2,UBE2C,UPP1,VSX2 | 286 (7) |
| 26s Proteasome | NA | complex | NA | -3.70e-01 | 0.0e+00 | ATG7,BCL2L11,BCL3,BIRC2,CDC25A,CDKN1A,ESR1,FOSL1,GCH1,GRIN1,HSPB8,ICAM1,IFI35,MAD2L1,MLF1,POLA1,PRKDC,SFTPB,SFTPC,SKIL,STAT1,TGM2,TK1,TNFSF10,UBE2I | 667 (19) |
| tyrphostin AG490 | NA | chemical drug | NA | -3.70e-01 | 1.0e-02 | ACE,AGT,BMP7,CCL5,CDKN1A,CFTR,ESR1,HDAC1,ICAM1,IRF1,JAK2,OSCAR,PCNA,SFTPB,STAT1,STAT3,TNFSF10 | 687 (19) |
| ARHGAP31 | 1.00e-02 | other | NA | -3.80e-01 | 2.0e-02 | BMP7,GADD45B,ITGA5,JUN,PKP1,TGFB2,TGFBR3 | NA |
| OSCAR | 1.25e+00 | other | NA | -3.80e-01 | 2.0e-02 | CCL24,CD83,CD86,ICAM1,JAK2,MMP19,TNFSF10 | NA |
| choline | NA | chemical - endogenous mammalian | NA | -3.80e-01 | 3.0e-02 | CDKN1A,ELN,GHRL,MBD2,MPDZ,OXTR,SLC5A7 | NA |
| ADGRE2 | NA | other | NA | -3.80e-01 | 3.0e-02 | CA9,CCND1,CDKN1A,JUN,LTBP1,TGFB2,WNT5A | NA |
| HDAC2 | -2.10e-01 | transcription regulator | NA | -3.80e-01 | 0.0e+00 | ASCL2,ATG7,AURKA,CCND1,CDKN1A,COL2A1,COMP,ESR1,EZH2,FAM107A,LAT,LGR5,MCM3,MYCN,NFATC1,PDGFB,PRIM2,RAD51,RAD54L,RRM2,SATB1,SLC12A5,SOX11,SYCE1,TDRKH,TNFSF10 | 649 (21) |
| mir-24 | NA | microRNA | NA | -3.80e-01 | 5.0e-02 | BCL2L11,CDKN1A,CXCR3,HNF1A,NDST1,NET1,PARP1,RORA,SERPINE1 | NA |
| MYD88 | -2.00e-01 | other | NA | -3.90e-01 | 0.0e+00 | ARID3A,ATF4,ATM,ATP6V1E1,AXIN2,BAMBI,BCL3,BLM,CCL5,CCNE1,CCRL2,CD200,CD200R1,CD83,CD86,CISH,CLEC10A,CLIC4,CXCL10,DCLRE1A,DUSP1,EDEM2,FBXO32,HSPA5,ICAM1,IL18,IRAK2,IRAK4,IRF1,IRF7,ITGAX,JUN,LGR5,MAFF,MCM3,MEFV,MLH1,MSH2,MSH3,NLRP3,OLR1,PARP1,PARP2,PCNA,PDE4B,PSTPIP2,SCARB1,SERPINE1,SH3BP2,SOCS1,TFRC,TLR2,TRIM63,TSC22D1,USP18,XPA | 679 (18) |
| BMP6 | 4.60e-01 | growth factor | NA | -3.90e-01 | 0.0e+00 | ADAMTS1,AQP5,ARHGAP18,CDKN1A,CYP39A1,FOSL1,ID3,INHA,INHBB,ITGA5,KLF4,Meis1,MYCN,PCSK6,PMEPA1,SAP30,SERPINE1,SLC39A10,SMARCA1,SORD,TXNRD1,VCL | 645 (20) |
| FAS | -4.00e-01 | transmembrane receptor | NA | -3.90e-01 | 0.0e+00 | AGER,APPBP2,ARAP2,BAD,BIRC2,BTG3,CCL5,CCRL2,CD200,CD83,CD86,CDC42EP2,CDKN1A,COL18A1,CXCL10,CXCL11,CXCR3,EGR2,EPOR,FSCN1,GBP1,GDE1,GRIA3,ICAM1,IER3,IL15RA,IL18,IRF1,ITGAV,JUN,LAT,LILRB4,MAP2K5,MERTK,MYO18A,NECTIN1,NR4A2,NUAK2,PLD2,PRKCB,PRKDC,PTP4A1,PTPN1,PTPRN,RDX,RGS3,RND1,SDC1,SERPINB2,SERPINE1,SFTPC,SKIL,TFRC,THBD,TLR2,TNC,TNFSF10,TRIB1,TWF2,TYK2,UGCG | 647 (17) |
| quercetin | NA | chemical drug | NA | -4.00e-01 | 2.0e-02 | APOL2,BAD,BHLHE40,Casp12,CAV1,CDKN1A,CXCL10,DUSP5,ESR1,FZD1,HSPA5,ICAM1,IER3,JUN,KLF4,LEP,MAP2,NEDD9,NF2,NLRX1,NR1D1,NT5E,POR,RFX2,SRD5A1,TLE4,TMC5,TOLLIP,TRPV6,WNT5A | NA |
| anisomycin | NA | chemical - endogenous non-mammalian | NA | -4.00e-01 | 0.0e+00 | CCND1,CDKN1A,DUSP1,GJA1,HDAC1,HMGA1,HSPA5,IRF1,JUN,RGS7,SDC1,SERPINE1,SKIL | 703 (19) |
| tert-butyl-hydroquinone | NA | chemical reagent | NA | -4.10e-01 | 1.0e-02 | AGL,CNR1,ERCC5,FOSL1,FTL,GADD45A,HNF1A,HSPA5,ICAM1,JUN,NQO1,PHKA1,SERPINE1,TXNRD1,WNT5A,ZNF184 | 737 (23) |
| JUP | -8.80e-01 | other | NA | -4.20e-01 | 0.0e+00 | AXIN2,PML,RNF8,SATB1,SPINT1 | NA |
| RGS4 | 4.00e-02 | enzyme | NA | -4.30e-01 | 0.0e+00 | ABHD10,CALN1,CPOX,GFOD1,GPC4,GPR15,GRIN3B,HEATR5B,ID4,INPP5J,MBNL1,NR4A2,NRIP3,PAQR8,SFI1,SIM1,SLC35A5,TFRC,TPRA1,UBE2G1,UGCG,VDR | NA |
| NC410 | NA | biologic drug | NA | -4.30e-01 | 0.0e+00 | CCL24,Ccl6,CDKN1A,CLEC10A,CXCL10,DUSP1,GADD45B,GBP5,HK2,HSPA1A/HSPA1B,IER3,IL1R2,IRF1,Mt1,OGFRL1,PARP14,SKIL,SOCS1,STAT1,STAT2,STAT3,TGM2 | NA |
| CCAR2 | -2.00e-02 | peptidase | NA | -4.30e-01 | 0.0e+00 | CCND1,DDB2,EAF1,GLP1R,MED12,NR1D1,PCNA,PRKCB,SLC36A4 | 236 (7) |
| TP63 | 7.00e-02 | transcription regulator | NA | -4.30e-01 | 0.0e+00 | ADAMTS1,ALOXE3,ATG10,ATG4C,ATG7,ATM,BAD,BCL2L11,BCL3,BDKRB2,BHLHE40,BLM,BMP7,BRAF,CAV1,CCND1,CCNE1,CDK18,CDKN1A,CDKN1C,CEACAM1,COL11A2,DDB2,DLL1,DNAJB1,EGR2,ELN,ERCC5,F11R,F2R,FGF11,FGF13,FOSL1,FSCN1,GADD45A,GAL,GREM1,HAGH,HIP1R,HK2,HSPA1A/HSPA1B,ICAM1,ID3,IER3,ING1,ITGA2,JUN,KLF4,L1CAM,LAMB3,LAMC2,MAD2L1,MAFF,MAP2K3,MLH1,MLPH,MRAS,NCS1,NT5E,OPRD1,PAK1,PCNA,PCNX2,PKP1,PKP2,PTPRU,RAD51,RAD9A,RASL11B,RASSF3,RBBP6,RPA1,RRM2,SERPINB2,SERPINE1,SLC7A11,SRD5A1,ST8SIA6,TGFB2,TH,THBS1,TIMP3,TINAGL1,TNC,TNFRSF10A,TNFSF10,TPSAB1/TPSB2,TRAF1,ULK2,VDR,VIL1,WDFY2,WNT5A,WNT5B | 736 (23) |
| FOXO3 | -1.30e-01 | transcription regulator | NA | -4.40e-01 | 0.0e+00 | Acan,ANGPT1,AURKA,BCL2L11,CAV1,CCND1,CDC42EP3,CDKN1A,CDKN1C,CHCHD4,COMP,CSNK2A2,CXCL10,EGR2,ELOVL5,ELOVL7,ESR1,FBXO32,GADD45A,GADD45B,GMNN,GRB14,HDAC8,HTATIP2,IER3,IFIH1,IL10RB,KLF4,LRAT,MAP1LC3A,MBNL1,MCM4,Mt1,MTHFD2,NCAPG2,NDRG1,NPHS2,NT5E,OSGIN2,PAK1,PAWR,PCNA,PDE3B,PLK1,PPRC1,PRCP,PRKCD,RBL2,RBM47,SATB1,SERPINE1,SKP2,TGFB2,TNFSF10,TRIM63,UBE2C,UCP2,YBX1,ZWINT | 670 (19) |
| HDAC1 | -6.00e-01 | transcription regulator | NA | -4.40e-01 | 0.0e+00 | ASCL2,ATG7,AXIN2,BAMBI,CCL5,CCND1,CCNE1,CDC25A,CDKN1A,CEACAM1,COL2A1,DUSP1,ESR1,FAM107A,LAT,LGR5,MAD1L1,MCM3,Meis1,Mt1,MYBL2,NCL,NFATC1,OSCAR,PDGFB,PLK1,PPP2R2B,PRIM2,RAD54L,RGS10,RRM2,SATB1,SERPINB2,SERPINE1,SLC12A5,SOX11,SREBF1,STAT3,SYCE1,TBX6,TDRKH,TGM2,UCP3,USP7,VDR | 576 (19) |
| Pkg | NA | group | NA | -4.50e-01 | 1.0e-02 | HK2,JUN,LEF1,LGR5,SLC6A4,VCL | NA |
| DMH1 | NA | chemical reagent | NA | -4.50e-01 | 1.0e-02 | CAV1,CCL5,IL18,LOX,VEGFC | NA |
| MR-409 | NA | chemical reagent | NA | -4.50e-01 | 2.0e-02 | C8orf44-SGK3/SGK3,CCL24,EPAS1,F2R,HMGA1 | NA |
| NFIC | -3.80e-01 | transcription regulator | NA | -4.50e-01 | 2.0e-02 | CCND1,CDKN1A,FABP7,LEF1,SFTPC,TNFSF18,WNT5A | NA |
| EIF4G2 | 2.10e-01 | translation regulator | NA | -4.50e-01 | 3.0e-02 | CDKN1A,JUN,KLF4,PLAT,TFCP2L1 | NA |
| HMGXB4 | -3.10e-01 | other | NA | -4.50e-01 | 4.0e-02 | ICAM1,IFIH1,PARP14,RNF213,TGM2 | NA |
| HAS2 | 2.80e-01 | enzyme | NA | -4.50e-01 | 5.0e-02 | DNAJB1,HAS1,HSPA1A/HSPA1B,LOX,PROX1 | NA |
| IL27 | 6.00e-02 | cytokine | NA | -4.50e-01 | 5.0e-02 | CCL5,CD86,CX3CL1,CXCL10,CXCL11,EGR2,ICAM1,IL10RB,IL15RA,IL18,IRF1,MX1,NFATC1,SOCS1,STAT1,STAT2,TLR3,TNFSF10,TNFSF18 | NA |
| ID2 | 5.50e-01 | transcription regulator | NA | -4.50e-01 | 0.0e+00 | ASCL2,AXIN2,BCL2L11,BCL3,BMP7,CCL5,CCND1,CCNE1,CD83,CDKN1A,CSF2RB,CXCR3,DLL1,DUSP1,DUSP22,EGR2,GADD45B,ICAM1,ID3,IFI16,INHBB,IRF6,JAK2,MAP3K14,NFATC1,NR4A3,PAWR,PIK3R5,PLK1,PROM1,RAPGEF4,RORA,SDC1,SPDEF,TGFBR3,TNFSF10,TOX2,TRAF1 | 647 (23) |
| LDL | NA | complex | NA | -4.50e-01 | 0.0e+00 | ATP2A2,BAD,BCL2L11,CCL5,CCND1,CDKN1A,CXCL10,CXCL11,DUSP1,EGR3,HSPA5,ICAM1,IRAK4,IRF7,ITGAV,JAK2,JUN,LAMB3,LASP1,MLH1,MX1,NLRP3,NR0B2,NR1H3,NR4A2,NR4A3,OLR1,OSCAR,PARP1,PLAT,SCARB1,SERPINE1,SOCS1,SREBF1,STAT3,TGFBR3,TLR2,TNFSF10,TRADD | 762 (18) |
| HAVCR1 | NA | other | NA | -4.60e-01 | 0.0e+00 | ANPEP,EGR2,FSCN1,HDAC1,HK2,IL1R2,IRF1,IRF9,JUN,L1CAM,NUDCD2,POMK,SLC39A7,SMARCA1,STAT1,STAT2,STAT3,STC2,TMEM19,TSPAN18 | 547 (10) |
| IL21 | NA | cytokine | NA | -4.60e-01 | 1.0e-02 | BCL2L11,CCL24,CCL5,CCRL2,CD86,CDKN1A,CLIC5,CXCL10,CXCR3,GBP5,IFI16,Igtp,IRF7,Irgm1,Klrk1,OAS2,PCNA,RORA,SLFN13,SOCS1,SOCS2,STAT2,STAT3,USP18 | NA |
| Ro31-8220 | NA | chemical drug | NA | -4.80e-01 | 0.0e+00 | CD55,CDKN1A,DUSP1,ICAM1,IL20,ITGA5,LAT,Mt1,SERPINE1,TNFSF10,TRAF1 | 725 (21) |
| deoxycorticosterone acetate/potassium chloride/sodium chloride | NA | chemical reagent | NA | -4.80e-01 | 2.0e-02 | AGT,Akr1b7,CCL5,ESR1,NOS1,REN,VDR | NA |
| IKK (complex) | NA | complex | NA | -4.80e-01 | 1.0e-02 | CCL5,CCND1,CXCL10,FANCC,FANCG,ICAM1,RAD51,RAD51C | 638 (18) |
| PRMT5 | -1.70e-01 | enzyme | NA | -4.80e-01 | 0.0e+00 | AXIN2,BRAF,CCND1,CCNE1,CUL4A,CXCL10,GAS1,KLF4,LEP,PTPRO,SLC45A3,SREBF1,STAT1 | 628 (20) |
| miR-34a-5p (and other miRNAs w/seed GGCAGUG) | NA | mature microRNA | NA | -4.90e-01 | 0.0e+00 | ARPP21,AXIN2,B4GALNT1,CCND1,CD55,CDC25A,CDKN1A,DLL1,DOCK8,FAM110C,GFRA1,GTF2IRD1,HAPLN3,HDAC1,ICAM1,KAT2B,KLF4,LEF1,MCM3,MYCN,SUPT3H,TBC1D19,THBS1 | 332 (7) |
| miR-221-3p (and other miRNAs w/seed GCUACAU) | NA | mature microRNA | NA | -4.90e-01 | 3.0e-02 | BCL2L11,CDKN1C,ESR1,ICAM1,SH3BP2,TIMP3,VASH1 | NA |
| dibutyl phthalate | NA | chemical toxicant | NA | -4.90e-01 | 3.0e-02 | GNRHR,INHBB,JUN,POR,SCARB1,SERPINE1 | NA |
| DACH1 | -4.40e-01 | transcription regulator | NA | -5.00e-01 | 2.0e-02 | CDC25A,CDKN1A,JUN,KLF4,PLAT,RAD51,SERPINE1,STC2 | NA |
| 2,4,5,2’,4’,5’-hexachlorobiphenyl | NA | chemical toxicant | NA | -5.00e-01 | 3.0e-02 | ACSL3,Akr1b7,CAMKK1,Cyp3a25 (includes others),FMO5,GADD45A,GADD45B,GFRA1,MAD1L1,MYO5B,PPP1R10,RBM47,SREBF1,TRA2A,TWF2,ZWINT | NA |
| Bay 11-7082 | NA | chemical - kinase inhibitor | NA | -5.00e-01 | 4.0e-02 | CCL5,CCND1,CD83,GJA1,GLRB,HSPA5,ICAM1,IL15RA,IL18,IRAK4,NLRP3,SH2D5,TLR2,TNFSF10 | NA |
| bexarotene | NA | chemical drug | NA | -5.10e-01 | 1.0e-02 | ABCB10,ASNS,BMP7,CCND1,CPLX1,DHRS3,DUSP1,DUSP5,EGR3,EIF1,FABP7,ICAM1,MAFF,Meis1,MERTK,MTHFD2,NOS1,NR4A2,PLAT,PNRC1,PTPRO,RET,RTN4R,SLC7A5,TGFB2,TGM2,TH | 752 (20) |
| tributyltin | NA | chemical reagent | NA | -5.10e-01 | 1.0e-02 | ANGPTL4,CIDEC,DOCK8,GPRC5A,IDH1,IL33,IRF7,KRT80,LEP,PCNA,PDE1B,PLIN4,SNTB1,SREBF1,STAT1,STAT2,SYT13,THBS1,TNC | NA |
| bromobenzene | NA | chemical toxicant | NA | -5.30e-01 | 1.0e-02 | ACTN4,CDKN1A,FDFT1,FMO1,GADD45A,HMGCS1,HSPA5,JUN,Mt1,Mt1m/Mt2A,NQO1,POR,TSC22D1 | NA |
| IFNAR2 | -7.00e-02 | transmembrane receptor | NA | -5.30e-01 | 0.0e+00 | CXCL10,CXCL11,GBP4,IFI44,IFIH1,IL18,OAS2,TGM2,TLR3,TNFSF10,USP18 | 608 (15) |
| NDRG1 | 1.87e+00 | kinase | NA | -5.30e-01 | 2.0e-02 | APOC2,BCL2L11,CAV1,CCND1,EGR2,JAK2,JUN,PARP1,PML,STAT3,TNC,TYK2 | NA |
| HIVEP1 | -3.00e-02 | transcription regulator | NA | -5.40e-01 | 0.0e+00 | CARD11,IL18,IL1R2,IL33,IRAK2,MAP2K3,MRAS,NFKBIB,PIK3R5,TGFBR3,TLR5,TNIP1,TRADD,TRAF1 | 418 (7) |
| CDC73 | -1.00e-01 | other | NA | -5.40e-01 | 0.0e+00 | CCND1,GBP1,HMGA1,IRF1,Meis1,SOCS1,STAT1 | 457 (14) |
| siponimod | NA | chemical drug | NA | -5.50e-01 | 1.0e-02 | ALPK1,BCL2L11,CD86,FAM78A,KLHL40,LEF1,PLEKHD1,PRKCD | NA |
| DNMT3A | -1.50e-01 | enzyme | NA | -5.60e-01 | 1.0e-02 | ABCD1,ACE,ADORA1,Akap17b,BCL2L11,CDK5RAP1,CNR1,HDAC4,IL20,IRF1,ITGAV,JUN,LRP2,MLH3,Mt1,MYH7B,NQO1,PDE1A,PLK1,PRKCB,SERPINH1,SKIL,TGM2,TLR3,TLR5,TSC22D1,TYK2 | NA |
| FKBP4 | -5.80e-01 | enzyme | NA | -5.60e-01 | 2.0e-02 | CEACAM1,ESR1,IL15RA,SREBF1,TIMP3 | NA |
| HEIH | NA | other | NA | -5.60e-01 | 1.0e-02 | DUSP1,FGF13,FGF7,GADD45B,HSPA2,JUN,PDGFC | NA |
| medroxyprogesterone acetate | NA | chemical drug | NA | -5.70e-01 | 0.0e+00 | ABCB10,ACTG1,ACTN4,ADAMTS1,ARSB,BCAR1,BCL2L11,CAV1,CAV2,CCL5,CCND1,CDKN1A,CDKN1C,CKB,CSF2RB,CXCL10,DDB2,EOGT,ESR1,F2R,FAM107A,FGF9,FOSL1,FZD7,GCH1,GNPTAB,HES6,HYAL3,ICAM1,ID3,ID4,IFI35,IL18,IL19,IL20,ITGA11,ITGA2,ITGAV,JAK2,JUN,LAMB3,LEF1,LTBP1,MAD2L1,MANBA,MCM3,MCM4,MSH2,NUSAP1,P4HA1,PAK1,PCNA,PDE1A,PDE3B,PDGFB,PDGFC,PDGFD,PLK1,PPP2R1B,PRC1,PRKX,SERPINE1,SMPD1,SOCS1,STAT1,STAT3,TGFB2,THBS1,TNC,VCAN,VCL,VEGFC,WNT5A,WNT5B | 858 (21) |
| TICAM1 | NA | other | NA | -5.70e-01 | 0.0e+00 | ATP6V1E1,BCL3,CCL5,CCRL2,CD86,CXCL10,CXCL11,DUSP1,ICAM1,IFI16,Ifi47,Igtp,IL15RA,IL18,IRF1,IRF7,Irgm1,ISG20,MAFF,MEFV,PDE4B,PSTPIP2,SERPINE1,SOCS1,TLR2,TLR3,TNFSF10,TSC22D1 | 415 (20) |
| IGFBP7 | 1.70e-01 | transporter | NA | -5.80e-01 | 3.0e-02 | ASNS,CCND1,CDKN1A,PCNA | NA |
| triamcinolone acetonide | NA | chemical drug | NA | -5.80e-01 | 2.0e-02 | ANGPTL4,AQP3,ATP10A,B4GALNT1,BCL2L11,BHLHE40,BMP7,DUSP1,EFNB2,ELK3,GAS1,GNAZ,IRF7,JUN,MDFI,MEGF9,NMD3,NOS1,PLXNC1,RASL11B,SLC16A1,SOCS2,ST3GAL5,STC2,TGFB2,TRIB1,TRIM21 | NA |
| CDKN2A | NA | transcription regulator | NA | -5.80e-01 | 0.0e+00 | AK1,AMD1,APPL2,ASNS,ATAD2,BCAT1,BCL2L11,BLM,BTG3,CCL24,CCL5,Ccl6,CCND1,CCNE1,CDC25A,CDKN1A,CX3CL1,CXCL10,DDR1,DUSP1,EGR2,EZH2,FGF11,FGF13,FLT3,GBP1,GNL3,GPRC5A,IFI35,IL1R2,IL20,ITGA2,ITGAV,JAK2,JUN,KANK2,LEF1,MAD2L1,MCM4,MYBL2,MYCN,PCNA,PDGFC,PLK1,PMEPA1,PML,POLK,RORA,RRM2,SERPINE1,SH3BP2,SHMT1,SKP2,SREBF1,TGFBR3,TK1,TMPO,VEGFC,VRK1 | 624 (18) |
| ERG | 1.00e-01 | transcription regulator | NA | -5.90e-01 | 1.0e-02 | ABCC4,ARHGEF6,AXIN2,CDK5RAP2,CHRM1,CNR1,COL11A2,DAAM1,EXT1,EZH2,F2R,FMNL2,HMMR,ICAM1,LAMA5,LEF1,MAP3K5,MYCN,MYO10,NDRG1,NFIL3,NR4A2,NRG1,PLAT,PLPP3,PSTPIP2,RASSF1,RGS3,RPA1,TDRD5,THBS1 | 631 (17) |
| TAS1R3 | 9.20e-01 | G-protein coupled receptor | NA | -5.90e-01 | 1.0e-02 | SLC16A1,SLC3A2,SLC5A1,SLC7A11 | NA |
| SP110 | -7.20e-01 | transcription regulator | NA | -6.00e-01 | 0.0e+00 | AQP3,ATM,BCL3,CXCL10,CXCL11,EEF2K,EGR3,F2R,IFIH1,IL18,ING1,IRF9,ITGAV,MX1,MYCN,NF2,NFIL3,PDGFC,PLK1,PLSCR1,RPA1,STAT1,TAF6,TGFBR3,TNFRSF21 | NA |
| PS-1145 | NA | chemical drug | NA | -6.00e-01 | 2.0e-02 | BIRC2,CCL5,HSPA5,ICAM1,IRF1 | NA |
| CTBP1 | -1.40e-01 | enzyme | NA | -6.00e-01 | 3.0e-02 | ACKR3,BMP7,C8orf44-SGK3/SGK3,CDKN1A,FSCN1,JUP,THBS1,VCAN,VDR | NA |
| pristane | NA | chemical toxicant | NA | -6.10e-01 | 0.0e+00 | CCL5,CD86,CXCL10,CXCR3,EPOR,ICAM1,IFI16,IRF7,mir-154,Oasl2,TLR3 | 673 (20) |
| WNT5A | 1.00e+00 | cytokine | NA | -6.20e-01 | 0.0e+00 | AXIN2,BIN1,BMPER,CCND1,CLDN4,COL2A1,CXCL10,DLL1,DUSP22,ESR1,F2R,GJA1,GREM1,ID3,INHBB,IRF1,LAMB3,LAT,LCP1,MAP3K21,MDFI,NR0B2,NT5E,PROM1,PTPN1,RBL2,RET,SDC1,SEMA3E,SERPINB2,STAMBPL1,STAT1,STAT3,TLR3,TLR5,TNFSF10,ZNF385B | 707 (19) |
| TWIST1 | -2.50e-01 | transcription regulator | NA | -6.30e-01 | 3.0e-02 | Acan,ADAMTS1,BCL2L11,C1QTNF1,CDKN1A,CLDN4,COL2A1,EFNB2,EGFL6,ESR1,EZH2,FBN2,FOSL1,HEG1,NT5E,PROM1,PTPRU,SLC28A3,TGFB2,TIMP3,TNFRSF21,VCAN,YBX1 | NA |
| Pdgf (complex) | NA | complex | NA | -6.30e-01 | 5.0e-02 | CAV1,CCND1,CDKN1A,EIF4E,GJA1,ICAM1,ITGA5,JUN,NR4A2,PCNA,PTPN1,SERPINE1,THBD,TIMP3 | NA |
| PAF1 | 1.50e-01 | other | NA | -6.30e-01 | 0.0e+00 | BAMBI,CCL5,HELZ2,IFI44,IFI44L,ISG20,KLF4,Meis1,OAS2,SERPINE1,ZNFX1 | 362 (7) |
| GRIN1 | 7.40e-01 | ion channel | NA | -6.30e-01 | 1.0e-02 | EGR3,GAL,GRIN1,GRIN2C,LOX,PENK,SERPINE1,SLC6A4,SOX11,TH,TMC5,TNC | 576 (11) |
| ARVib-7 | NA | chemical reagent | NA | -6.30e-01 | 2.0e-02 | CCND1,HNRNPA1,MAD2L1,NUSAP1,PLK1,PRKDC,UBE2C,XRCC6,ZMIZ1,ZWINT | NA |
| ARVib-31 | NA | chemical reagent | NA | -6.30e-01 | 2.0e-02 | CCND1,HNRNPA1,MAD2L1,NUSAP1,PLK1,PRKDC,UBE2C,XRCC6,ZMIZ1,ZWINT | NA |
| NME1 | -6.00e-02 | kinase | NA | -6.40e-01 | 0.0e+00 | BOP1,CCND1,CDKN1A,COIL,CSTF1,FZD1,L1CAM,NETO2,NOP58,RNGTT,SERPINE1 | 633 (20) |
| paricalcitol | NA | chemical drug | NA | -6.40e-01 | 3.0e-02 | AGT,ICAM1,NLRP3,PCNA,REN,S100G,TRPV6,VDR | NA |
| Collagen(s) | NA | complex | NA | -6.50e-01 | 1.0e-02 | ATF4,BCL3,CD55,CREB3L1,PLCB3,RAD1,SERPINH1,THBS1,TNC | NA |
| CL097 | NA | chemical reagent | NA | -6.50e-01 | 2.0e-02 | BCL3,CD86,CXCL10,MX1,TNFSF10 | NA |
| AHR | -2.90e-01 | ligand-dependent nuclear receptor | NA | -6.50e-01 | 0.0e+00 | ABCC4,ACKR3,AFMID,ATOH8,ATP4A,BZW2,CAMK2N2,CARD11,CCL5,CCND1,CCNE1,CCNF,CDKN1A,CGREF1,CSF2RB,CXCL10,CXCL11,DMXL2,DNAJB1,DUS2,EGR2,EHD1,ELN,ELOVL5,EMILIN2,ESR1,FBN2,FGF9,FOSL1,FZD7,GADD45A,GAS1,GPAM,GREM1,HK2,HSPA5,HSPH1,IL1R2,IRF1,ITGA5,JUN,KDSR,LAMA5,LAMC2,LTBP1,MMD2,Mt1,NEDD9,NLRP3,NQO1,NT5E,PDE4B,PDGFB,PLAT,PLK1,POLA1,RNGTT,SDC1,SERPINB2,SERPINE1,SIM1,SREBF1,STAT3,STEAP2,TGFB2,TH,THBS1,TIMP3,TK1,TLR5,TOLLIP,UGCG,VCL,VEGFC | 749 (16) |
| ATR | -5.60e-01 | kinase | NA | -6.50e-01 | 2.0e-02 | ATM,PCNA,POLI,RRM2,WRN | NA |
| CETP | NA | enzyme | NA | -6.50e-01 | 5.0e-02 | HSPA5,NR0B2,PDIA4,PLIN3,SREBF1 | NA |
| STAT2 | -7.30e-01 | transcription regulator | NA | -6.50e-01 | 0.0e+00 | CAV1,CCL5,CD86,CXCL10,GBP1,IFI35,Ifi47,IRF1,IRF7,IRF9,MX1,OAS2,Oasl2,RTP4,SOCS1,STAT1,TNFSF10,USP18 | 567 (17) |
| PARP1 | -6.80e-01 | enzyme | NA | -6.50e-01 | 1.0e-02 | CCL5,CCND1,CD83,CD86,CDKN1A,CXCL10,GBP4,ICAM1,Igtp,JUN,PARP1,POLA1,PRIM2,RAPGEF4,RPA1,SFTPB,SH3BP2,SOCS1,SOCS2,STAT1,VEGFC | 621 (18) |
| SAMSN1 | 8.00e-02 | other | NA | -6.60e-01 | 0.0e+00 | ATM,CXCL10,HDAC1,HELZ2,IL15RA,IL18,IRF1,IRF7,ISG20,MERTK,PLA1A,PLAT,PML,SAP30,SDC1,SOCS1,STAT1,STAT2,TLR3,TRIM21,TSC22D1 | 329 (7) |
| CEBPB | 7.00e-02 | transcription regulator | NA | -6.60e-01 | 0.0e+00 | ADRB3,AGT,Akr1b7,APLNR,ASNS,ATAD2,ATM,AURKA,CCL5,CCND1,CCNE1,CCP110,CCRL2,CD86,CDC25A,CDC42EP3,CDKN1A,CFTR,CHEK2,CIT,CSE1L,CXCL10,CYP27B1,DDB2,DDX39A,DSCC1,EFNB2,EZH2,FBXO32,FTL,FZD1,GADD45A,GAS1,HMGA1,HMMR,HNRNPD,ICAM1,IER3,INMT,IRF7,IRF9,JUN,KIF18B,LEP,MCM3,MCM4,MLH1,MSH2,MSH5,MYBL2,NOP56,NR1H3,OXTR,PCNA,PLK1,PLXND1,POLD1,PRIM2,PRKCD,PRMT1,PTGFR,RAD1,RORA,RPA1,RRM2,S100G,SCARB1,SEMA3E,SERPINB2,SERPINE1,SHMT1,SMC6,SREBF1,SRP54,STAT1,STAT3,TBRG4,TFRC,TK1,TMPO,UBA2,UPP1,VCAN,VDR,XPO1,XRCC6 | 671 (20) |
| bisindolylmaleimide I | NA | chemical drug | NA | -6.60e-01 | 1.0e-02 | ACE,AGT,AQP3,BAD,CD55,CDKN1A,GNRHR,HSPA5,ICAM1,ID3,Mt1,NR4A2,OXTR,PCNA,PRKCD,SERPINE1,TNFSF10,TRAF1 | 730 (21) |
| MECP2 | 9.00e-02 | transcription regulator | NA | -6.60e-01 | 2.0e-02 | ADGRF5,APOL2,ARHGAP42,CD86,DOCK8,EPHB6,ESR1,EZH2,FOXP2,GALNT15,HCRTR1,HSPA5,Mt1,NACC2,NAV3,PATJ,PROM1,RASSF1,RPH3A,SCN4B,SLC12A5,TH,TIAM1,UNC5C,UNC5D | NA |
| miR-124-3p (and other miRNAs w/seed AAGGCAC) | NA | mature microRNA | NA | -6.60e-01 | 1.0e-02 | APEX2,ATL3,BTG3,CAPRIN2,CAV1,CHSY1,CLDND1,ELK3,ELOVL5,F11R,FAM83H,HDAC4,HDAC5,HTATIP2,LRRC1,LRRC58,MYO10,NFATC1,PHF19,PTBP1,PTBP2,RBM47,RFFL,SENP8,SLC16A1,STAT3,TMEM109,TMEM248,TNFRSF21,TOM1L1,TTC7A,TUBB6 | NA |
| genistein | NA | chemical drug | NA | -6.60e-01 | 1.0e-02 | ACE,ANGPTL4,ATF4,ATP6V1B1,BAD,BCL3,BTG3,CCL5,CCND1,CD86,CDKN1A,CFTR,CHEK2,CX3CL1,CXCL10,CXCR3,DUSP1,ESR1,EXT1,FXYD5,GADD45A,GNPTAB,HAS1,HSPA1A/HSPA1B,HSPA5,HYAL3,ICAM1,IRF7,JUN,KCNJ2,KDSR,MANBA,Mt1,NR1H3,OSBPL3,PCNA,PLAT,PLK1,REN,RPH3A,S100G,SERPINE1,SLC26A6,SLC6A14,SMPD1,SOCS1,TFEB,VDR,WNT5A | 703 (18) |
| CALR | 6.00e-02 | transcription regulator | NA | -6.70e-01 | 1.0e-02 | ATP2A2,CDKN1A,GJA1,HSPA5,ICAM1,SCNN1A,SCNN1G,SREBF1,VCL,Vmn2r1 | 744 (22) |
| MAP3K5 | -9.00e-01 | kinase | NA | -6.80e-01 | 0.0e+00 | ACE,BCL2L11,CCND1,CDKN1A,JUN,MAP3K5,MSH2,TGM1 | 637 (21) |
| hyaluronic acid | NA | chemical - endogenous mammalian | NA | -6.80e-01 | 2.0e-02 | ACKR3,BAD,BCL3,CCL5,CD83,CD86,COL2A1,CXCL10,HMMR,ICAM1,JUN,NR4A2,PCNA,PROX1,SERPINE1,TGFB2,TLR2 | NA |
| DOCK8 | -1.06e+00 | other | NA | -6.90e-01 | 0.0e+00 | ATM,CXCL10,HDAC1,HELZ2,IL15RA,IL18,IRF1,IRF7,ISG20,MERTK,PLA1A,PLAT,SAP30,SOCS1,STAT1,STAT2,TLR3,TRIM21,TSC22D1 | NA |
| RGS2 | -7.00e-01 | enzyme | NA | -6.90e-01 | 0.0e+00 | AQP3,BAD,BLVRA,EVA1A,GCHFR,GJA1,IL18,ILVBL,MAGED1,PDIA4,PDLIM2,PLAT,PLXND1,SCARB1,SLC16A1,SREBF1,TOR2A,Ubb,UGCG | 560 (16) |
| MARCHF2 | NA | enzyme | NA | -6.90e-01 | 0.0e+00 | CCL5,CXCL10,TFRC,TNFRSF10A | 489 (15) |
| NKX6-1 | 6.70e-01 | transcription regulator | NA | -6.90e-01 | 0.0e+00 | GFRA1,HNF1A,NR4A3,UBE2C,UNC5C,VGF | 322 (7) |
| PDCD4 | -1.90e-01 | other | NA | -6.90e-01 | 2.0e-02 | ARF4,JUN,LOX,VEGFC,YBX1 | NA |
| FOSB | -2.20e-01 | transcription regulator | NA | -6.90e-01 | 3.0e-02 | CCND1,FOSL1,GNRHR,RABEP2,SERPINB2,SERPINE1,TH | NA |
| TRH | 4.00e-02 | other | NA | -6.90e-01 | 4.0e-02 | DIO2,DUSP1,F2R,JUN,KCNA5,SFTPB,UBOX5 | NA |
| HDAC7 | -2.40e-01 | transcription regulator | NA | -7.00e-01 | 5.0e-02 | CCND1,CDKN1A,MMD2,NFATC1,SCNN1A | NA |
| IGF2 | -6.60e-01 | growth factor | NA | -7.00e-01 | 0.0e+00 | CCND1,CDKN1A,CRY1,DUSP1,EGR2,FABP7,GADD45A,GAS1,GCH1,IDH1,IER3,ITGA5,KIFAP3,LEP,MCM4,MSH2,MYBL2,NDRG1,PDGFB,PRDM16,PSPC1,RAD51,RRM2,SATB1,SERPINE1,SFTPB,SFTPC,SKAP2,SLC30A1,SREBF1,SURF6,ULK2 | 671 (20) |
| RNF187 | -1.50e-01 | enzyme | NA | -7.10e-01 | 2.0e-02 | BHLHE40,CCND1,CDKN1A,EDA2R,IRF1,ISG20,JUN,KLF4,MOV10,NECTIN4,PML,SLC30A1,STAT1 | NA |
| RB1 | -4.80e-01 | transcription regulator | NA | -7.10e-01 | 0.0e+00 | ADAM10,APPL2,ATAD2,BCL2L11,BLM,BTG3,CCL5,CCND1,CCNE1,CD83,CDC25A,CDKN1A,CELSR3,CLIC4,CYP27B1,DDB2,DDX11,DIO2,DPP3,DUSP1,E2F4,EGR3,EZH2,FOSL1,GADD45A,GADD45B,GEM,GMNN,GMPS,GNRHR,GPR157,GPR83,GPRC5A,INMT,ITGAV,JUN,KANK2,LGR5,LRAT,MAP2K3,MCM3,MCM4,MSTO1,MYBL2,MYOM2,NDUFA5,NR4A2,NR4A3,OLR1,OSMR,P2RY14,PARP1,PCNA,PLK1,PMEPA1,PROM1,RAD51,RAMP2,RBL2,RRM2,SENP2,SERPINE1,SH3BP2,SKP2,SLC5A8,SOX7,TGFB2,TMPO,TRIM72,UBE2C,VRK1 | 610 (20) |
| MSB0011359C | NA | biologic drug | NA | -7.30e-01 | 0.0e+00 | Ccl6,CDKN1A,CLEC10A,CXCL10,DUSP1,GADD45B,GBP5,HK2,HSPA1A/HSPA1B,IER3,IRF1,Mt1,OGFRL1,PARP14,SKIL,SOCS1,TGM2 | NA |
| SPRY2 | 1.10e-01 | other | NA | -7.30e-01 | 0.0e+00 | AMMECR1,ANGPTL4,AXIN2,CAB39L,CAV1,CDKN1A,CXCL10,EPAS1,ETV1,FABP7,GALNT3,GLRX,IL33,ITGA2,LCP1,MYCN,PCNA,PTPN1,SATB1,SDCCAG8,SFTPB,SFTPC | 692 (19) |
| cholic acid | NA | chemical - endogenous mammalian | NA | -7.40e-01 | 3.0e-02 | ABCC4,ACE,AGT,APOC2,FABP7,FDFT1,LRP2,NR0B2,NR1H3,RAD23B,Slco1a4,SREBF1 | NA |
| mir-31 | NA | microRNA | NA | -7.50e-01 | 4.0e-02 | BAMBI,EZH2,ITGA2,ITGA5,RDX,TIAM1 | NA |
| MAP3K7 | -1.40e-01 | kinase | NA | -7.50e-01 | 0.0e+00 | CCL5,CXCL10,GBP1,GCH1,IFI44,IFIH1,IL19,IRF1,IRF7,JUN,MAP2K3,OAS2,PDGFB,SERPINE1,TNFSF10,WNT5A | 627 (18) |
| TAL1 | -1.70e-01 | transcription regulator | NA | -7.50e-01 | 1.0e-02 | ARPP21,BTBD3,CCNE1,CDKN1A,CEP70,CMTR2,CPLX1,CUL4A,DSCC1,ELOVL4,EPOR,GALNT7,GSDMD,ICAM1,JUN,MAP2,MCM4,NFYA,NOS1,NR4A3,OXR1,PTPRU,RIPK4,SENP7,SERPINB2,TNFSF10,TPSAB1/TPSB2,TUBB4B,XRCC6,ZFYVE9 | NA |
| COL6A1 | 3.20e-01 | other | NA | -7.60e-01 | 3.0e-02 | AK1,ENO3,IDH1,TNC | NA |
| Stat1 dimer | NA | complex | NA | -7.60e-01 | 5.0e-02 | CCL5,CXCL10,CXCL11,DUSP1,IRF1 | NA |
| 2-amino-5-phosphonovaleric acid | NA | chemical - other | NA | -7.60e-01 | 0.0e+00 | ADAMTS1,ALS2,ATF4,BTG3,CAMKK1,CCDC126,CCDC28A,CX3CL1,CYB561A3,DUSP1,EGR2,EGR3,EXT1,FHDC1,GADD45A,GADD45B,GFRA1,GRIN1,HDAC4,HDAC5,JUN,LSM11,LURAP1,NR4A2,NR4A3,REM2,SENP7,STOML1,TMEM200A,TSPAN18 | 344 (8) |
| miR-296-5p (miRNAs w/seed GGGCCCC) | NA | mature microRNA | NA | -7.60e-01 | 1.0e-02 | CCND1,HMGA1,MAP2K3,NUMBL,PCNA,TNC | NA |
| MAP2K3 | -7.50e-01 | kinase | NA | -7.60e-01 | 4.0e-02 | ATP2A2,CDKN1A,CXCL10,ICAM1,IRF9,NFATC1,OSCAR,RGS7,SERPINE1,STAT1,TNFSF10 | NA |
| WNT1 | NA | cytokine | NA | -7.70e-01 | 1.0e-02 | AXIN2,CCND1,CDKN1A,CSNK2A2,DDIT4L,DLL1,DUS2,E2F4,EIF3C,EIF4E,EIF5A,GAS1,HNF1A,JUN,LEF1,Meis1,MRAS,RBL2,SERPINE1,SIM1,VEGFC | 641 (20) |
| ADRB | NA | group | NA | -7.70e-01 | 0.0e+00 | ACAT2,ADAMTS4,ANGPTL4,BAD,BHLHE40,CCND1,CCNE1,CDKN1A,CLEC4D,CXCL10,DIO2,E2F4,FAM110C,GADD45A,HMGCS1,HSD17B7,HSD3B7,ICAM1,IDH1,JUN,KLF4,LSS,LTBP1,NCL,NQO1,NR4A2,NR4A3,PCNA,PDGFB,RAD51,RAD9A,RBL2,SLC7A11,TRAF1 | 748 (25) |
| Growth hormone | NA | group | NA | -7.70e-01 | 1.0e-02 | AGT,AKR1B1,ANGPTL4,BMP7,CCL5,CCND1,CISH,CLDN15,COL18A1,CX3CL1,CYB5B,CYP27B1,DDR1,FZD7,GHRL,ICAM1,IER3,IGFALS,IRF1,JUN,NEDD9,NR1D1,PCNA,RPH3A,SCARB1,SCNN1A,SOCS1,SOCS2,SSTR1,TNFSF10,TSC22D1,Ubb | NA |
| GATA1 | NA | transcription regulator | NA | -7.80e-01 | 0.0e+00 | ABCB10,ABCC4,BCL2L11,BZW2,CCL5,CCND1,CDKN1A,CXCR3,EPOR,EZH2,Gar1,HDAC11,INHA,INHBB,IPO5,ITGA2B,ITGAX,MAGED1,MAP3K5,MCM3,Meis1,MSH2,MTHFD1,MYCN,NCL,NCOA7,NFIL3,NR4A2,PCNA,POLD1,PSTPIP2,PTGDR2,RAD54L,SATB1,SLC38A9,SLC3A2,TFDP2,TFEB,TFRC,TGM2,USP16,VDR,ZBTB42 | 328 (14) |
| prostaglandin A2 | NA | chemical - endogenous non-mammalian | NA | -7.80e-01 | 1.0e-02 | CCND1,CDKN1A,ICAM1,NR4A3,PCNA | 657 (21) |
| CYP1B1 | 4.70e-01 | enzyme | NA | -7.80e-01 | 1.0e-02 | BMP7,Bmp8b,CCND1,CCNE1,DSP,FGF7,FLRT3,GPRC5A,MCM4,Mt1,NQO1,RAD51,SHANK2,SKP2,SLFN13,SOCS2,STEAP3,TNFSF10 | NA |
| adavosertib | NA | chemical drug | NA | -7.90e-01 | 0.0e+00 | AURKA,CD83,CXCL10,CXCL11,DHX58,ICAM1,IFI35,IFIH1,IL10RB,IL15RA,IL18,IRAK2,IRF1,IRF7,IRF9,ISG20,MERTK,MX1,RRM2,STAT1,THBS1,TLR5 | 707 (19) |
| CCN5 | NA | growth factor | NA | -7.90e-01 | 0.0e+00 | AXIN2,CCND1,DSP,ESR1,ITGA5,JUN,JUP,KLF4,LAMB3,LAMC2,PROCR,SERPINE1,TGFBR3 | 644 (19) |
| Alpha catenin | NA | group | NA | -7.90e-01 | 3.0e-02 | ADAMTS1,ADAMTS4,AXIN2,BCL3,CXCL10,EGFL6,ELK3,ELN,FMNL2,IRF1,ITGA5,LEF1,MMP19,STEAP2,TGM2,TNC,TSPAN8 | NA |
| Dst | 4.50e-01 | other | NA | -7.90e-01 | 1.0e-02 | CCL5,GRIN2C,MAP2,RPL3L,RTN4R,SCN4B,TGFB2,TMEM150C,UCP2 | NA |
| mir-34 | NA | microRNA | NA | -8.00e-01 | 0.0e+00 | CCND1,CCNE1,CDC25A,DLL1,FOSL1,HK2,ITGA2B,KCNH1,KCNH2,LEF1,MYCN,NCAPG2,PPP1R10,REM2,SEMA4B,SHPK,SLC7A11,TIMP3,TUBB4B | 607 (19) |
| tretinoin | NA | chemical drug | NA | -8.00e-01 | 0.0e+00 | ABLIM1,ADAM10,ADAM11,ADAMTS4,AGT,ALOXE3,ANGPTL4,ANPEP,APLNR,ASNS,ATF4,ATOH8,ATP2A2,ATP2B2,AURKA,B3GALT1,BAMBI,BCL3,BHLHE40,BIRC2,BRIX1,CALML3,CAMKK1,CASZ1,CCL24,CCND1,CCNE1,CCRL2,CD86,CDKN1A,CEACAM1,CEBPZ,CFTR,CHGB,CNR1,COL2A1,CSE1L,CXCL10,CYP4F22,DDB2,DDX42,DGAT1,DHRS3,DHX58,DIO2,DLL1,DPYSL5,DSP,DUSP1,DUSP9,E2F4,EHD1,EIF3B,EIF3C,EIF4A1,EIF4E,EIF6,ELN,ELOVL4,ENOX1,ERCC5,ETV1,ETV6,FBN2,FGF12,FGF13,FGR,FOSL1,GAL,GBP4,GDE1,GFRA1,GJA1,GMNN,GPR158,GPRC5A,GRB10,GREM1,GRIN1,GTPBP10,HDAC1,HMGA1,HNF1A,HNRNPD,HOXB6,HOXB7,HSPA2,ICAM1,ID3,IDE,IER3,IFI16,IFI35,IFI44,IFI44L,IFIH1,INMT,IRF1,IRF9,ITGA2,ITGA2B,ITGAX,JAK2,JUN,KAT2B,KCNJ2,KCNJ5,KLF4,LRAT,LRP2,MAD1L1,MAP2,MAP2K3,MAP2K5,MAP3K5,MAPKAPK2,MARCKSL1,Meis1,MERTK,mir-154,MLH1,MLH3,MMP19,MRAS,MSH3,MSH5,MSI1,Mt1,MTHFD2,MYBL2,MYCN,NAT2,NCL,NCOA2,NDRG1,NFATC1,NFKBIB,NPHS2,NR0B2,OAS2,ORC3,OSCAR,PAK1,PARP14,PARP9,PDE1B,PDGFB,PENK,PKP2,PLAT,PLSCR1,PML,PNLIPRP2,PNPLA1,PNRC1,POR,PPM1G,PRAM1,PRDM9,PRKCB,PRKCD,PRMT1,PROM1,PTPRU,RAD23B,RAI14,RBL2,REC8,REN,RET,RNF213,RPA1,RTKN2,RTP4,SERPINB2,SERPINE1,SFTPB,SFTPC,SHANK2,SKAP2,SKP2,SLC16A1,SLC25A15,SLC7A11,SLCO2A1,SLFN5,SMPD1,SOCS1,SOX7,SP110,SREBF1,STAT1,STAT2,STAT3,TAF6,TEX15,TFCP2L1,TFRC,TGFB2,TGFBR3,TGIF2,TGM1,TGM2,TH,THBD,THBS1,TK1,TLR2,TLR3,TLR5,TNC,TNFRSF10A,TNFSF10,TNIP1,TPT1,TUBGCP5,TYK2,Ubb,UBE2C,UCP2,UCP3,USP18,VCL,VDR,VEGFC,VGLL3,WNT5A,XPA,XRCC6,YBX1,ZNF703 | 781 (17) |
| PRKAA2 | -5.30e-01 | kinase | NA | -8.10e-01 | 0.0e+00 | CAMKK1,CDKN1A,CHGB,DLGAP2,GIPR,GLP1R,GRIA3,HSPA5,ICAM1,IFI44,Ifi47,JAK2,LEP,NOS1,PARP3,PPP1R3B,PRDM16,PTPRN,SLC16A1,SREBF1,TGM2,UCP2,YBX1,ZNF462 | 677 (22) |
| TLR7 | -1.30e-01 | transmembrane receptor | NA | -8.10e-01 | 0.0e+00 | Abi3bp,AGT,CCL5,CCND1,CD83,CD86,CDKN1A,CXCL10,DIO2,DMXL2,FOSL1,HIVEP2,ICAM1,IER3,IFI35,IFI44,IFI44L,IRAK4,IRF1,IRF7,IRF9,ISG20,ITGAX,KCNH1,MLPH,MX1,NR1H4,OAS2,PLAT,SOCS1,SPRED3,STAT1,STAT2 | 276 (14) |
| losartan potassium | NA | chemical drug | NA | -8.10e-01 | 0.0e+00 | ACE,AGT,ANGPT1,ATF4,ATP2A2,BMP7,CAV1,CXCL10,Cxcl3,GJA1,HSPA5,Ifi47,IL18,ITGAV,MAP2,NOS1,NPHS2,OLR1,PRDM16,REN,SERPINE1,STAT3,TGFB2,TH,UCP2 | 727 (19) |
| PXDN | -4.00e-01 | enzyme | NA | -8.20e-01 | 0.0e+00 | CCRL2,CDKN1A,DUSP1,JUN,LOX,NFIL3 | NA |
| BCOR | 1.70e-01 | transcription regulator | NA | -8.20e-01 | 0.0e+00 | ADAMTS1,ARID3A,BMP7,CDKN1A,COL18A1,COL2A1,ETV6,GAS1,HOXB7,NFATC1,STAT2 | 510 (13) |
| PKNOX2 | 4.00e-01 | transcription regulator | NA | -8.20e-01 | 1.0e-02 | CDKN1A,COL2A1,ESR1,GADD45A,HDAC1,STAT1 | NA |
| PPP1R13L | -4.20e-01 | transcription regulator | NA | -8.20e-01 | 1.0e-02 | CDKN1A,DSP,GJA1,ITGAV,JUP,PKP1 | 386 (7) |
| ETV7 | NA | transcription regulator | NA | -8.20e-01 | 1.0e-02 | CCL24,GCH1,ICAM1,IFI35,PARP14,PLSCR1,PROCR | NA |
| ACSS2 | -3.20e-01 | enzyme | NA | -8.20e-01 | 1.0e-02 | DGAT1,GPAM,HLCS,LSS,SCARB1,SREBF1 | 494 (13) |
| STAT1/3/5 dimer | NA | complex | NA | -8.20e-01 | 2.0e-02 | BCL3,CISH,EPAS1,IRF1,SOCS2,TIMP3 | NA |
| TASL | NA | enzyme | NA | -8.20e-01 | 2.0e-02 | CCL5,EPSTI1,GBP4,GBP5,ISG20,USP18 | NA |
| TRADD | -8.20e-01 | other | NA | -8.20e-01 | 3.0e-02 | CX3CL1,CXCL11,ICAM1,IRF1,RND1,TRAF1 | NA |
| pimagedine | NA | chemical drug | NA | -8.20e-01 | 5.0e-02 | AGER,CAV1,GADD45B,ICAM1,NOS1,SERPINE1,TNFSF10 | NA |
| RAS | NA | group | NA | -8.20e-01 | 0.0e+00 | ANPEP,AURKA,BCL2L11,CAV1,CCND1,CDKN1A,CLDN4,CXCL10,FOSL1,GRIN1,HMGA1,Ifi47,IRF1,JUN,LRAT,PDGFB,PML,SERPINE1,SREBF1,STAT1,STAT2,TGM2,UPP1 | 702 (24) |
| KAT5 | 1.00e-01 | transcription regulator | NA | -8.20e-01 | 1.0e-02 | ADAMTS1,BIRC2,CCND1,CDKN1A,CFTR,CHAC1,CHRM1,COL2A1,EFNB2,EPG5,ERCC5,GADD45A,GADD45B,GALNT7,GPAM,HSPA5,MAD1L1,MAD2L1,MICALL2,MPG,NPTX2,NT5E,PDIA4,PLCH1,POLI,RAD54B,STEAP3,VGF | 643 (21) |
| 1810019D21Rik | NA | other | NA | -8.30e-01 | 0.0e+00 | BDKRB2,CDKN1A,EDA2R,ITGA2,KCNH2,MYCN,NIPAL1,RAPGEF3,RTN4R,SLC7A11,TCEAL1,THBD,TMEM44 | NA |
| E. coli B4 lipopolysaccharide | NA | chemical toxicant | NA | -8.40e-01 | 0.0e+00 | ANXA11,BAD,CA13,CCL5,CD83,CD86,CXCL10,ESR1,FLT3,GBP4,HK2,HSPB8,ICAM1,IFI16,IFI35,Igtp,IL33,INVS,LCP1,LILRB4,NLRP3,Oasl2,PARP9,PDLIM5,RAB20,RAB7B,RTP4,SCARB1,SERPINH1,SIKE1,SLC14A1,SOCS1,STC2,TEX15,TH,TLR2,TNFSF10,TOLLIP,TRADD,USP18 | 555 (18) |
| N6AMT1 | -1.70e-01 | enzyme | NA | -8.40e-01 | 0.0e+00 | ASCL2,Casp12,CC2D2A,CDKN1A,CIT,FADS1,FHDC1,FZD7,LCP1,LGR5,NFIA,PDE3B,POLD1,POLI,PPAT,PTPRO,RASL11B,SLC39A10,SORD,SPICE1,SRL,TBC1D9,TGIF2,TNFSF10,TRIM37,VDR | NA |
| TSC22D3 | NA | transcription regulator | NA | -8.40e-01 | 0.0e+00 | BCL2L11,CCL5,CCND1,CD83,CD86,CDKN1A,DUSP1,EGR2,EGR3,ICAM1,LEP,LILRB4,TLR2 | 653 (18) |
| RXRB | -3.80e-01 | ligand-dependent nuclear receptor | NA | -8.50e-01 | 1.0e-02 | ABCA4,ATF4,CD86,CUL4A,CXCL10,DHRS3,ECT2,FLRT3,FLT3,GCHFR,IRF7,LSR,MATN4,Muc1,MUC13,OSMR,PDGFB,RAMP2,RBPJL,RRP12,SATB1,SNAPC4,SREBF1,TEAD3,TNFSF10,VCAN | NA |
| Pam3-Cys | NA | chemical toxicant | NA | -8.70e-01 | 4.0e-02 | CCL5,CD83,CD86,CXCL10,PLAT,SERPINE1,TLR2,TNC | NA |
| TGFBR2 | -4.30e-01 | kinase | NA | -8.70e-01 | 0.0e+00 | ACSL3,ANGPTL4,ATF4,BCAT1,BCL3,BHLHE40,CCND1,CCNE1,CD200,CD83,CDKN1A,CKB,CLIC4,CRISPLD2,DUSP14,DUSP28,EGR2,EPAS1,EXT2,FGF7,FGF9,GADD45B,GAL,GJA1,HK2,ICAM1,ID3,IL1R2,ING1,JUN,JUP,KCNH1,KCNJ8,Klrk1,LY6D,MAP2K3,MAPKAPK2,METRNL,MYOF,NFIL3,NT5E,ORAI1,PDGFB,PLSCR1,RBL2,RPUSD3,SDC1,Serpinb6b,SERPINE1,SH3BP2,SKIL,SLC7A5,SPAG1,SPATA2,STAT3,STC2,TGFB2,THBD,THBS1,TOX2,UPP1,VCL,ZMIZ1,ZSWIM4 | 731 (20) |
| COP1 | NA | enzyme | NA | -8.70e-01 | 0.0e+00 | CCL5,CDKN1A,CISH,CXCL10,EGR3,ESR1,GFRA1,GJA1,GREB1,HSPB8,ICAM1,IFI16,ITGAX,KAZN,KCNK5,PEX11A,RET,SREBF1 | 583 (13) |
| SASH1 | -4.20e-01 | other | NA | -8.90e-01 | 0.0e+00 | ATM,CXCL10,HDAC1,HELZ2,IL15RA,IL18,IRF1,IRF7,ISG20,MERTK,PLA1A,PLAT,PML,SAP30,SOCS1,STAT1,STAT2,TLR3,TRIM21,TSC22D1 | NA |
| CSF1R | -3.00e-02 | kinase | NA | -9.00e-01 | 1.0e-02 | CCND1,CCNE1,CDKN1A,IDE,JUN,LGR5,NR1H3,PCNA,STAT3 | NA |
| HSD11B1 | 4.20e-01 | enzyme | NA | -9.00e-01 | 2.0e-02 | AGT,ANGPTL4,GPAM,LEP,NR1H3,PNPLA2,SREBF1,UCP2 | NA |
| dihydrotestosterone | NA | chemical - endogenous mammalian | NA | -9.00e-01 | 0.0e+00 | ABCC4,ACE,ACKR3,ACSL3,ADAMTS1,ADRB3,AGT,Akr1b7,AMD1,ATAD2,ATP2A2,AXIN2,BCAR1,BMP7,CCND1,CCNE1,CDKN1A,CX3CL1,DIO2,ELN,ELOVL7,ESR1,ETV1,EZH2,F2R,FBXO32,FGF7,FOXP2,FTL,GAS1,Gm12854/S100a11,GNRHR,GOLGA4,GRB10,GREB1,HK2,HNF1A,HOXB7,HSPA1A/HSPA1B,INHBB,ITGA2,JUN,KCNH2,LAMA5,LEF1,LEP,LOX,LTBP1,MAFF,MCM4,Mt1,MYOF,NDRG1,NOS1,NPEPPS,OXTR,PMEPA1,PRIM2,REN,RPL9,SFTPB,SFTPC,SLC25A40,SLC2A5,SLC3A2,SLC7A7,SRD5A1,SREBF1,STBD1,TGFB2,TGFBR3,TGM2,THBS1,TIMP3,TNFSF10,VCAN,VCL,WNT5A | 823 (22) |
| AIP | -4.60e-01 | transcription regulator | NA | -9.00e-01 | 0.0e+00 | ACKR3,ADGRV1,ADRA1D,AKAP5,DUSP1,GPRC5A,P2RY14,PDE1B,PDE4B,PRKCD,RET,RGS7 | NA |
| STEAP3 | -8.70e-01 | transporter | NA | -9.00e-01 | 1.0e-02 | FRMD5,ITGA5,LOX,NEDD9,NR4A3,P4HA1,SORBS2,SORBS3,TFRC,TGFB2,TGM2 | NA |
| N-cor | NA | group | NA | -9.10e-01 | 0.0e+00 | AXIN2,BIN1,CCL5,CCND1,CDKN1A,CIDEC,CXCL10,DHRS3,ELOVL5,ESR1,FZD1,HIVEP2,HK2,IDH1,INPP4B,MBNL1,NFATC1,OLR1,PDGFB,RAB20,Scd2,SOCS1,SREBF1,TBX4,TBX6,TRERF1,USP18,ZNF703 | 790 (26) |
| NFATC2 | -5.30e-01 | transcription regulator | NA | -9.10e-01 | 0.0e+00 | AQP5,ATM,BCL2L11,CCL5,CCNE1,CCNF,CD83,CD86,CDKN1A,CISH,COL2A1,CX3CL1,CXCL10,EGR2,EGR3,EZH2,GBP4,HDAC1,HELZ2,IER3,IL18,IRF1,IRF7,ISG20,JARID2,JUN,MERTK,NFATC1,PLAT,PML,PTPN1,SLC3A2,SOCS1,SOCS2,STAT1,STAT2,TLE4,TLR2,TLR3,TRAF1,TSC22D1 | 737 (17) |
| HNF1B | -1.50e-01 | transcription regulator | NA | -9.10e-01 | 2.0e-02 | AXIN2,BHLHE40,DUSP1,EXT1,F11R,FZD1,HNF1A,ID3,ID4,IFT88,KIFAP3,NR1H4,PLEK2,PSTPIP2,SERPINH1,SLC5A1,Sult1d1,UPP1 | NA |
| Tcf7 | 7.00e-02 | transcription regulator | NA | -9.10e-01 | 0.0e+00 | ARHGEF26,C3orf70,CCL5,Ccl6,CD200,CD83,CDKN1A,CISH,CXCR3,EGR2,EGR3,ELK3,EMILIN2,EZH2,FLT3,FOSL1,FRMD6,GEM,GPR15,GPR83,Gprasp2,HEATR9,ID3,IL15RA,LEF1,LPCAT2,LY6D,MAPKAPK2,METRNL,NCOA7,OSBPL3,PARP1,PDGFB,PENK,PTPRO,SDC1,Serpinb6b,SOCS2,SOX12,STAT1,STX11,TEX15,TIAM1,TSC22D1,ZNF467 | 532 (7) |
| TLR4 | -3.20e-01 | transmembrane receptor | NA | -9.20e-01 | 0.0e+00 | AGER,ATM,BAMBI,CCL5,CCRL2,CD200,CD200R1,CD86,CISH,CXCL10,CYP27B1,FBXO32,GJA1,HDAC1,HELZ2,HK2,HSPA5,ICAM1,IFI16,Ifi47,Igtp,IL15RA,IL18,IRAK4,IRF1,IRF7,Irgm1,ISG20,LILRB4,MERTK,MX1,NLRP3,NOS1,NR1H4,NR4A2,NR4A3,OXTR,PAK1,PLA1A,PLAT,PML,PROX1,PTGFR,SAP30,SCARB1,SGMS2,SLC7A11,SMPD1,SOCS1,SREBF1,STAT1,STAT2,STAT3,TFRC,TLR2,TLR3,TNFRSF10A,TNFSF10,TRAF1,TRIM21,TRIM63,TSC22D1,UGCG | 765 (18) |
| TAFAZZIN | NA | enzyme | NA | -9.20e-01 | 0.0e+00 | ADAMTS1,ANXA11,ASCL2,BCL2L11,CAV1,CAV2,CCL5,CCND1,CCNE1,CCRL2,CD86,DIDO1,DUSP1,EGR2,GSTT2/GSTT2B,IDH1,IFI16,IRAK2,Irgm1,LCP1,LGR5,LOX,LRP2,LY6D,MAD2L1,MYOF,NAV3,P4HA1,PCNA,PDE3B,PPP1R3B,PRKCB,RNF213,SAMD4A,SERPINE1,SFTPC,SORBS2,STAT1,TELO2,TFRC,THBS1,TRAF1,UPP1 | 685 (19) |
| AZ-1 | NA | chemical - protease inhibitor | NA | -9.20e-01 | 3.0e-02 | EHD1,EIF4A1,ERCC6L,F11R,GNPDA1,JUN,PDLIM5,SCARB1,SYTL4,TFRC,THBS1,TUBB2A | NA |
| TOB1 | -1.70e-01 | transcription regulator | NA | -9.20e-01 | 1.0e-02 | ATM,BANP,CCND1,CDKN1A,GMNN,MATN4,MIS18BP1,PHLDA3,RBBP6,UBA6 | 509 (13) |
| DYSF | -9.00e-02 | other | NA | -9.20e-01 | 2.0e-02 | ACTG1,CAV1,CD55,CD83,CORO1C,CXCL10,DGAT1,DNAJB1,FTL,HSPA1A/HSPA1B,IFI16,LCP1,LILRB4,PLPP3,SREBF1 | NA |
| rhodamine 6G | NA | chemical toxicant | NA | -9.30e-01 | 0.0e+00 | CCND1,CCNE1,PCNA,PRC1 | NA |
| hydrocortisone | NA | chemical - endogenous mammalian | NA | -9.30e-01 | 2.0e-02 | BDKRB2,CCND1,CCNE1,CD86,FGF7,FGF9,GADD45B,GBP1,H6PD,ICAM1,ITGA2,LOX,Mt1,NUSAP1,PLAT,PROX1,SERPINE1,STC2,TH,TLE2,TLR2,ZNF143 | NA |
| MAVS | -1.70e-01 | other | NA | -9.30e-01 | 0.0e+00 | CCL5,CD83,CXCL10,CXCL11,DHX58,ICAM1,IFIH1,IL15RA,IL18,IRAK2,IRF7,ISG20,MERTK,MX1,OAS2,Oasl2,SOCS1,STAT1,STAT2,THBS1,USP18,USP8 | 270 (14) |
| EGOT | NA | other | NA | -9.30e-01 | 0.0e+00 | CXCL10,GBP1,MX1,OAS2,TGFB2,USP18 | NA |
| IgG | NA | complex | NA | -9.30e-01 | 0.0e+00 | ARSB,BCL3,BHLHE40,BIRC2,CCL5,CD83,CD86,CDKN1A,CLDN4,CXCL10,CXCR3,DSP,DUSP1,DUSP14,EGR2,EGR3,EHD1,GADD45B,GPRC5A,HSPA5,ICAM1,IFIH1,IL1R2,IRF1,NT5E,PDE3B,PMEPA1,PPIF,SERPINB2,SERPINE1,SPINT1,STAT1,STAT2,STAT3,STK24,THBS1,TLR3,TNC,TNFRSF10A,TNIP1,TRAF1,TUBB2A,UGCG,VGF | 750 (17) |
| estrogen receptor | NA | group | NA | -9.50e-01 | 0.0e+00 | BMP7,CAV1,CAV2,CCND1,CDH9,CLDN4,CNNM4,CPM,DSP,F11R,FGF12,FGF13,GAL,GREB1,HSPA1A/HSPA1B,ICAM1,JUN,JUP,LAMC2,MMP15,NEDD9,NT5E,OXTR,PDGFC,PDGFD,PLEK2,POR,S100G,SERPINE1,TGFB2,TGFBR3,TGM2,TIMP3,TNC,VEGFC,WNT5A,WNT5B | 815 (18) |
| BMI1 | NA | transcription regulator | NA | -9.50e-01 | 1.0e-02 | ATM,AURKA,CCNE1,CDKN1A,HK2,ID4,LOX,MCM3,P4HA1,PARP9,TGFB2,VEGFC | NA |
| mir-15 | NA | microRNA | NA | -9.50e-01 | 3.0e-02 | CCL5,CCND1,CCNE1,CDC25A,HSPA1A/HSPA1B,MX1,PCNA,PNPLA2,RORA,SLC6A4,SREBF1,TFAP4,UCP2 | NA |
| PDLIM2 | -6.80e-01 | other | NA | -9.50e-01 | 3.0e-02 | B3GNTL1,CCND1,CLCN4,CRISPLD2,FHDC1,FOXRED2,IFI44,OBSL1,PDLIM2,PHLDA3,RNF128,SLC10A4,STAT1,STC2 | NA |
| raloxifene | NA | chemical drug | NA | -9.60e-01 | 0.0e+00 | ASCC3,BCL3,CCL5,CCND1,CDKN1A,DUSP1,EGR3,EPOR,ESR1,F2R,FMO5,GPRC5A,GREB1,HSPA1A/HSPA1B,IER3,IL18,INHBB,INPP5J,IRF6,JUN,L1CAM,MPPED2,NDRG1,PCNA,SERPINE1,SMPD1,SOCS1,TFRC,TGFB2,THBD,TIMP3 | 791 (23) |
| TO-901317 | NA | chemical reagent | NA | -9.60e-01 | 3.0e-02 | ADAM11,Akr1b7,APOC2,Casp12,CCL24,CCND1,ELOVL5,FADS1,FDFT1,FMO1,FMO5,GPAM,HK2,LIPG,MID1IP1,Mt1,NR0B2,NR1D1,NR1H3,POR,RAI14,SAA2-SAA4,SCARB1,Scd2,SKP2,SREBF1,Sult1d1,TGM2,TIMP3 | NA |
| TWIST | NA | group | NA | -9.70e-01 | 0.0e+00 | B4GALNT1,CDKN1A,RORA,SERPINH1,ST3GAL5,YBX1 | NA |
| MAX | 5.30e-01 | transcription regulator | NA | -9.70e-01 | 1.0e-02 | Ccl6,CDC25A,CDKN1A,EZH2,FBXO32,GADD45A,GADD45B,HK2,HMGA1,JARID2,MTHFD1,NCL,UBE2C,WRN,YBX1 | NA |
| irbesartan | NA | chemical drug | NA | -9.70e-01 | 5.0e-02 | ACE,AGER,ICAM1,ITGAV,LEP,SERPINE1 | NA |
| STING1 | NA | other | NA | -9.70e-01 | 0.0e+00 | CCL5,CD83,CD86,CXCL10,CXCL11,GBP4,GBP5,GJA4,HOPX,HSPA5,ICAM1,IFI16,IFI35,IFI44,IFI44L,IL15RA,IL18,IL33,IRF7,IRF9,MX1,PLAT,THBS1,UPP1,USP18 | 421 (19) |
| Rb | NA | group | NA | -9.70e-01 | 0.0e+00 | CCND1,CCNE1,CDKN1A,CRYAA/LOC102724652,ECT2,EZH2,GMNN,HDAC1,MAD2L1,MCM3,MCM4,MYBL2,PCNA,PLK1,POLD1 | 513 (16) |
| FLCN | 4.00e-02 | other | NA | -9.70e-01 | 0.0e+00 | ACKR3,ADAMTS1,AGER,ATP6V1E1,BCL2L11,BHLHE40,CEACAM1,CKB,COL2A1,DUSP5,HK2,ICAM1,KLF4,L1CAM,LCP1,MANBA,PLXND1,PRDM16,SEMA3E,SERPINE1,UCP3 | 443 (12) |
| DNMT1 | -1.10e-01 | enzyme | NA | -9.80e-01 | 1.0e-02 | CA9,CDKN1A,CNR1,ESR1,EZH2,MLH1,Mt1,NDRG1,PRDM16,RASSF1,RGS10,SERPINB2,SLC7A11,SOCS1,TIMP3,WNT5A | NA |
| MIR17HG | NA | other | NA | -9.80e-01 | 0.0e+00 | ATM,BCL2L11,CCND1,CCNE1,CDKN1A,DLL1,DLL3,FBN2,FZD1,GLG1,HDAC4,HEG1,HOPX,LAMA5,LTBP1,MDFI,MYCN,PTPRU,SEMA3E,SOX11,TBX6,WNT5A,ZFYVE9,ZNF703 | 491 (7) |
| DCN | 1.80e-01 | other | NA | -9.80e-01 | 1.0e-02 | CDKN1A,CDKN1C,CXCL10,DUSP1,ICAM1,ITGAV,SDC1,SERPINE1,TFEB,THBS1,TIMP3 | 771 (20) |
| CIDEC | 1.07e+00 | other | NA | -9.80e-01 | 4.0e-02 | DGAT1,DIO2,LEP,PNPLA2,SDC1,SERPINE1,SREBF1 | NA |
| H3B-8800 | NA | chemical drug | NA | -1.00e+00 | 0.0e+00 | CCL5,CXCL10,CXCL11,MX1 | NA |
| CIC | 5.00e-02 | transcription regulator | NA | -1.00e+00 | 0.0e+00 | CCND1,ETV1,FOSL1,ITGA2,MAFF | 178 (7) |
| CCDC80 | 2.20e-01 | other | NA | -1.00e+00 | 0.0e+00 | AXIN2,CCND1,FZD7,LEP | NA |
| PAK2 | -3.50e-01 | kinase | NA | -1.00e+00 | 0.0e+00 | CKB,DUSP1,GADD45A,HMGA1,ID3,IFI16,PROX1,SMARCA2,WRN | 595 (11) |
| PRDX5 | 4.00e-01 | enzyme | NA | -1.00e+00 | 0.0e+00 | AURKA,LEP,PLK1,WNT5A | 393 (7) |
| IFNW1 | NA | cytokine | NA | -1.00e+00 | 1.0e-02 | CD83,CD86,CXCL10,CXCL11,IFIH1,TLR3 | 190 (8) |
| EFNA5 | 3.50e-01 | kinase | NA | -1.00e+00 | 1.0e-02 | ADAMTS4,FOSL1,IRF1,IRF7,NOS1,NT5E,PKP1,PLAT,TGM1,UBE2C | 407 (7) |
| ethidium | NA | chemical drug | NA | -1.00e+00 | 1.0e-02 | CCND1,CCNE1,PCNA,PRC1,SERPINE1 | NA |
| brusatol | NA | chemical reagent | NA | -1.00e+00 | 1.0e-02 | CCL5,CXCL10,ICAM1,SERPINE1 | NA |
| HNF4G | -6.80e-01 | transcription regulator | NA | -1.00e+00 | 2.0e-02 | Btnl4/Btnl6,DAAM1,Fhod1,ITGA2,ITGA5,ITGAV,LAMB3,LAMC2,VCL | NA |
| PDE4B | 1.32e+00 | enzyme | NA | -1.00e+00 | 2.0e-02 | CCL5,CXCL10,CXCL11,DUSP1 | NA |
| CUL3 | 1.50e-01 | enzyme | NA | -1.00e+00 | 2.0e-02 | Acan,ACE,CCND1,CCNE1,COL2A1,FBXO32,NQO1,NT5C1A,PDLIM5,UCP3 | NA |
| ACTN4 | 6.40e-01 | transcription regulator | NA | -1.00e+00 | 2.0e-02 | ANGPTL4,CCND1,MYCN,SERPINE1,WNT5A | NA |
| miR-503-5p (miRNAs w/seed AGCAGCG) | NA | mature microRNA | NA | -1.00e+00 | 3.0e-02 | CCND1,CCNE1,CCNF,CDC25A,CDKN1A | NA |
| mifepristone | NA | chemical drug | NA | -1.00e+00 | 0.0e+00 | Acan,ACE,BCAT1,BMP7,CAV1,CCND1,CDKN1A,CEACAM1,CFTR,CISH,COL18A1,COL2A1,DIO2,DUSP1,EFNB2,EGR2,FDFT1,GAL,GJA1,GNRHR,H6PD,HSPA5,ICAM1,INHBB,ITGA2,JUN,JUP,KLF4,LAMA5,LAMB3,LAMC2,LOX,LSR,MAD2L1,Mt1,Muc1,NDRG1,OXTR,PCNA,PLAT,RFX2,S100G,SCARB1,SERPINE1,SOX11,Sult1d1,TIMP3,TK1,VCAN,VDR | 828 (22) |
| SNAI1 | 1.10e-01 | transcription regulator | NA | -1.00e+00 | 1.0e-02 | Acan,CCND1,CCNE1,CD55,CDKN1A,CLDN4,COL2A1,FMNL2,FOSL1,ID4,INHA,ITGA2,L1CAM,LASP1,LEF1,MSI1,RORA,SDC1,SERPINE1,SERPINH1,SLC28A3,TGFBR3,THBD,VDR | 727 (19) |
| MET | -8.00e-02 | kinase | NA | -1.01e+00 | 0.0e+00 | AQP3,ATM,AURKA,CCND1,CDKN1A,ESR1,FBXO32,IL15RA,IL18,JUN,KLF4,LEF1,MAD1L1,MAD2L1,MERTK,PIM3,PLK1,PTPN1,RRM2,TLR3,TRIM21,TRIM63,TSC22D1,VEGFC | 705 (25) |
| BTK | 3.50e-01 | kinase | NA | -1.01e+00 | 0.0e+00 | CCNE1,CD86,CDC25A,CDKN1A,CISH,CXCL10,IFI35,IFI44L,IL18,IRF1,IRF9,ISG20,ITGAV,ITGAX,JUN,LILRB4,MTHFD2,MX1,NCL,NFATC1,OAS2,STAT1 | 711 (21) |
| GATA4 | -3.00e-02 | transcription regulator | NA | -1.02e+00 | 1.0e-02 | ADORA1,ANGPT4,ATG7,ATP2A2,CCBE1,Ccl6,CDC42EP3,DIO2,DSCC1,EPOR,FGF16,GAS1,GJA1,HSPA5,IFI16,INHA,INHBB,INMT,IRF6,JUN,KCNA5,KCNJ2,MPG,NF2,NUSAP1,PDLIM3,PGBD5,PHKA1,PLIN4,PML,SFTPC,SLC9A3,SRD5A1,TGM2 | NA |
| salubrinal | NA | chemical reagent | NA | -1.02e+00 | 1.0e-02 | ATF4,CCL5,CDC25A,HSPA5,NFATC1 | 324 (7) |
| FADD | -7.00e-02 | other | NA | -1.04e+00 | 0.0e+00 | CCNE1,CDKN1A,CXCL10,DHX58,ELMOD2,GADD45B,ICAM1,IFIH1,IRF7,JUN,NFIL3,PIWIL4,RNPC3,SOCS1,STAT1,STAT2,TIAM2,TLR3 | 333 (17) |
| miR-18a-5p (and other miRNAs w/seed AAGGUGC) | NA | mature microRNA | NA | -1.04e+00 | 0.0e+00 | AXIN2,BCL2L11,BTG3,CCND1,CDKN1A,ESR1,THBS1 | 501 (7) |
| EGR3 | 1.67e+00 | transcription regulator | NA | -1.04e+00 | 0.0e+00 | APBB1,ATXN1,BHLHE40,CISH,FCHSD2,FXYD5,GALNT7,HEATR5A,HEG1,HOXB7,ID3,INHBB,JUN,NDRG1,NECTIN1,NFIL3,PDE4A,PLXND1,PSD,RAB20,RASAL1,RET,RORA,SLC15A2,SLC4A3,SOCS1,TBC1D9,TRAF1,TSC22D1,XKRX | 312 (7) |
| MEF2A | -4.00e-01 | transcription regulator | NA | -1.04e+00 | 2.0e-02 | ATP2A2,CXCL10,ENO3,FGF16,IFI44,Ifi47,IRF1,IRF7,ISG20,JUN,Oasl2,TGFB2,THBD | NA |
| MAPKAPK2 | 8.70e-01 | kinase | NA | -1.04e+00 | 3.0e-02 | CXCL10,HSPA5,HSPB8,ICAM1,IL18,NFKBIB,PLA1A,PLAT,TLR3,TSC22D1 | NA |
| INSR | 2.50e-01 | kinase | NA | -1.05e+00 | 1.0e-02 | ACTN4,Akr1b7,ATP2A2,CCND1,CD83,CDKN1A,CEBPZ,CRY1,CSTB,DGAT1,DUSP1,EGR2,FDFT1,GADD45A,GAS1,GCH1,GPAM,GRB10,HMGCS1,HOXB7,HSD17B7,IDE,IDH1,IER3,ITGA5,KIFAP3,LCP1,LDB2,LEP,LSS,MARCKSL1,MCM4,mir-154,MYBL2,MYCN,MYOM2,NDRG1,NR1H3,OLR1,PDE4B,PDGFB,PNPLA2,PSPC1,PTPRN,RAD51,RNF4,RRM2,SATB1,SCARB1,SERPINE1,SGMS2,SKAP2,SLC30A1,SLC39A7,SOCS2,SOX7,SREBF1,SURF6,TLR2,TSC22D1,UCP2,UCP3,ULK2,YBX1 | 704 (24) |
| KDM5B | 8.70e-01 | transcription regulator | NA | -1.06e+00 | 0.0e+00 | AURKA,BBS9,CAV1,CCND1,CCNE1,ECT2,EHD1,ESR1,FJX1,GADD45A,GAL,GREB1,HMMR,IPP,MCM3,NEDD9,NMB,PDE3B,PSD3,SCNN1A,SMARCA2,TGFB2,TUBB2A | 544 (17) |
| M344 | NA | chemical reagent | NA | -1.07e+00 | 1.0e-02 | ADAM10,APBB1,BIN1,BRPF1,HDAC11,HDAC4,NRG1,SERPINE1,SIRT4 | NA |
| Gm13288 (includes others) | NA | cytokine | NA | -1.07e+00 | 1.0e-02 | CD83,CD86,IRF1,TLR3 | NA |
| L-methionine | NA | chemical - endogenous mammalian | NA | -1.07e+00 | 2.0e-02 | ASNS,ATF4,CDK19,GADD45B,HSPA5,IFI16,NF2,NUSAP1,PLAT,PRC1,SLC7A11 | NA |
| Gm12602 | NA | other | NA | -1.07e+00 | 4.0e-02 | ANPEP,CGREF1,DUSP5,SERPINB2 | NA |
| CBL | -8.00e-02 | transcription regulator | NA | -1.07e+00 | 2.0e-02 | BCL2L11,CDKN1A,CFTR,CSF2RB,FLT3,JAK2,LAT,LEP,STAT1,UCP3 | NA |
| DSCAML1 | 1.00e-01 | other | NA | -1.07e+00 | 2.0e-02 | GRIN3B,ID3,KCNJ2,KLF4,MAP2,MICALL2,NOS1,PDGFB,PLXNC1,PRKCB,SHANK2,SNCAIP,TUBB2A,VGF | NA |
| OPA1 | 1.00e-01 | enzyme | NA | -1.07e+00 | 2.0e-02 | AGER,ATF4,HSPA5,NLRP3,TLR2 | NA |
| EIF4E | 6.10e-01 | translation regulator | NA | -1.08e+00 | 1.0e-02 | Acan,ADAMTS15,BAD,BIRC2,CCND1,CDKN1A,CLEC7A,DGUOK,ESR1,FOSL1,HLA-G,IFI16,IL12RB1,IL15RA,IL18,IL33,KAT2B,LSM10,MAPKAPK2,PCNA,RRM2,SKP2,SLC2A5,SLC6A4,TMEM119,TNC,UBE2C,UPP1,VEGFC | 733 (22) |
| A2M | 3.20e-01 | transporter | NA | -1.11e+00 | 1.0e-02 | ATF4,BAD,CCND1,GADD45B,GRIN1,HSPA5,MAP3K5,SREBF1,WNT5A | NA |
| CX3CL1 | -1.16e+00 | cytokine | NA | -1.11e+00 | 0.0e+00 | ADAMTS1,ATF4,BAD,BCL2L11,BMP7,CCND1,CX3CL1,EFNB2,ETV1,FABP7,GPRC5B,GYG1,HSPA5,ICAM1,IFI16,IRF7,Meis1,MICOS10-NBL1/NBL1,NDNF,PCNA,PROM1,SPON2,TGFB2,TH | 731 (20) |
| PADI4 | 1.40e-01 | enzyme | NA | -1.11e+00 | 3.0e-02 | CDKN1A,GADD45A,HSPA5,NLRP3 | NA |
| ATF3 | 1.40e-01 | transcription regulator | NA | -1.11e+00 | 0.0e+00 | AMPD2,ASNS,ATF4,AURKA,BHLHA15,CCL5,CCND1,CCNE1,CD83,CDC25A,CDKN1A,CHAC1,CX3CL1,GBP4,HSPA5,ICAM1,JUN,MSH2,PENK,PLK1,POLA1,POLD1,POLE2,PRIM2,RRM2,SERPINE1,STAT3,TK1,TLR2 | 661 (20) |
| imiquimod | NA | chemical drug | NA | -1.12e+00 | 0.0e+00 | CA9,CCL5,CD86,CDC25A,CLEC7A,COMP,CXCL10,CXCR3,CYP27B1,DDB2,ERCC5,FOSL1,FSCN1,HHIP,HMGA1,ICAM1,IFI35,IL18,IL19,IRF7,ISG20,MSH2,MX1,NEK3,NME6,PPP1R3B,PRDM5,PRIM2,RAD23B,RNF213,RPA1,SOCS1,STAT1,TNFSF10,TRPM4,TXNDC5,UBAC1,XPA | 346 (17) |
| miR-125b-5p (and other miRNAs w/seed CCCUGAG) | NA | mature microRNA | NA | -1.12e+00 | 4.0e-02 | ADAMTS1,ANAPC16,ARID3A,CBLN2,CDC25A,HK2,ID3,JARID2,JUN,LCP1,OSBPL9,PROM1,TOR2A,TSPAN8,UBE2I | NA |
| Bcl9-Cbp/p300-Ctnnb1-Lef/Tcf | NA | complex | NA | -1.13e+00 | 0.0e+00 | AXIN2,CCND1,GJA1,HNF1A | NA |
| ADRB1 | 0.00e+00 | G-protein coupled receptor | NA | -1.13e+00 | 3.0e-02 | DIO2,HSPA5,LEP,MAP1LC3A,THBS1 | NA |
| erythromycin | NA | chemical drug | NA | -1.13e+00 | 4.0e-02 | CD86,ICAM1,TLR2,TLR3 | NA |
| SCD | -3.30e-01 | enzyme | NA | -1.14e+00 | 0.0e+00 | ADRB3,ANGPTL4,CXCL10,DAGLB,DGAT1,DIO2,ELOVL5,ELOVL7,GADD45A,GNAT1,GPAM,HMGCS1,HSPA5,IL18,JUN,KLF4,LEF1,LEP,LRAT,NR1H3,PNPLA2,PRDM16,PTPN1,Scd2,Scd3,SGMS2,SMPD1,SREBF1,TGM1,THBS1,TNC,UCP2,UCP3,UGCG,VDR | 779 (24) |
| molybdenum disulfide | NA | chemical reagent | NA | -1.15e+00 | 3.0e-02 | CKB,CSF2RB,ELN,FZD7,GPC4,GREM1,HAPLN3,HMGA1,IFI44,ITGA11,JUP,L1CAM,LAMA5,LIMS2,MLPH,NQO1,SERPINB2,THBS1,TINAGL1 | NA |
| N’-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide | NA | chemical reagent | NA | -1.17e+00 | 1.0e-02 | ATM,CDC25A,CISH,IER3,SDC1 | 142 (3) |
| PLAT | 1.37e+00 | peptidase | NA | -1.17e+00 | 3.0e-02 | AGER,ANGPT1,CCND1,CXCL10,JUN,PLAT,SERPINE1 | NA |
| PML | -7.50e-01 | transcription regulator | NA | -1.18e+00 | 0.0e+00 | ACTG1,CCND1,CCNE1,CDKN1A,CIT,CXCL11,DNAJB6,EPSTI1,FTL,GADD45A,GPAM,HMGCS1,HSD17B7,IFI35,IFI44,IFI44L,IFIH1,IRF7,ISG20,JUP,LEP,LIPC,MAFF,MX1,NDRG1,NQO1,NSFL1C,OAS2,PLSCR1,PML,SREBF1,STAT1,TXNRD1,UCP2,UCP3 | 677 (21) |
| EHD2 | 3.20e-01 | other | NA | -1.18e+00 | 0.0e+00 | CAV1,CAV2,PNPLA2,SREBF1 | NA |
| IFNAR1 | -1.90e-01 | transmembrane receptor | NA | -1.18e+00 | 0.0e+00 | CCL24,CCL5,CD86,CLEC4D,CLIC5,CXCL10,CXCL11,Cxcl3,DLL1,GBP4,HMGCS1,IFI16,IFI44,IFIH1,IL18,IRF1,IRF7,ITGAV,OAS2,Oasl2,PLAT,RTP4,SDC1,SERPINE1,SOCS1,STAT1,TGM2,THBS1,TLR2,TLR3,TNFSF10,TRIM21,USP18,VCAN | 568 (16) |
| Sb202190 | NA | chemical drug | NA | -1.18e+00 | 5.0e-02 | ANGPTL4,CCND1,CD55,CD86,CDKN1A,CFTR,CXCL10,HAS1,HSPA5,ICAM1,IL18,IL20,MAP1LC3A,P4HA1,SERPINE1,TGM1,TNFRSF10A,VDR | NA |
| IRF6 | 7.00e-01 | transcription regulator | NA | -1.19e+00 | 3.0e-02 | CD86,CLEC10A,IL18,KLF4,MAD1L1,NLRP3,NR4A2,SCARB1,SOCS1,TFAP4 | NA |
| PDCD10 | 1.10e-01 | other | NA | -1.20e+00 | 1.0e-02 | KLF4,PROCR,SERPINE1,THBD,THBS1 | 542 (11) |
| DDX17 | NA | enzyme | NA | -1.20e+00 | 1.0e-02 | CCND1,CDKN1A,FOSL1,JUN,NET1 | NA |
| SB203580 | NA | chemical drug | NA | -1.21e+00 | 0.0e+00 | Acan,ADAMTS4,AGT,ATM,BCL2L11,CCL5,CCND1,CCNE1,CCRL2,CD200,CD55,CD83,CD86,CDKN1A,CEACAM1,CHEK2,CX3CL1,CXCL10,CXCL11,Cxcl3,DUSP1,ELOVL7,F2RL3,FDFT1,GADD45A,GBP4,GJA1,GLRX,GMPR,HAS1,HK2,HSPA5,ICAM1,IER3,IFI35,IL12RB1,IL18,IRF1,IRF7,ISG20,JUN,MX1,NOL9,NPHS2,NQO1,NR4A3,OLR1,P4HA1,PATJ,PDE4B,PDGFB,PENK,PLA1A,PLAT,PRMT1,RBM3,RGS7,RND1,RNF149,Serpinb6b,SERPINE1,SGMS2,SOX7,STAT1,STC2,TGFB2,TGM1,TGM2,THBS1,TIMP3,TLR2,TLR3,TMCC1,TNFSF10,TRADD,TRAF1,TRPV1,UCP2,UCP3,VDR,VEGFC,VGLL3 | 718 (16) |
| miR-199a-5p (and other miRNAs w/seed CCAGUGU) | NA | mature microRNA | NA | -1.21e+00 | 3.0e-02 | CDKN1A,CSTB,DDR1,GPRC5A,ID3,KLF4,LAMC2,NECTIN1,NEDD9,RND1,TGFBR3,WNT5B | NA |
| RABL6 | -2.80e-01 | other | NA | -1.21e+00 | 0.0e+00 | ATXN1,CDC25A,CHEK2,CX3CL1,EZH2,HMMR,MAD2L1,PARP2,PLK1,POLA1,POLD1,POLE2,PRC1,RAD54B,SERPINH1,UBE2C,VRK1 | 463 (10) |
| SMARCA5 | 2.00e-01 | transcription regulator | NA | -1.21e+00 | 5.0e-02 | ALPK1,ANKRD6,CDKN1A,GFRA1,GPRC5B,GRIA3,IRF7,KBTBD11,KHDC1L,MAST4,PHLDA3,PLXND1,RASGRP4,RTP4,SEMA4A,TDRD5,VWCE | NA |
| E2F2 | -1.00e-01 | transcription regulator | NA | -1.22e+00 | 0.0e+00 | CCND1,CCNE1,CDC25A,CDKN1A,EZH2,MCM3,MCM4,MLH1,MYBL2,MYCN,PCNA,POLA1,RAD51,RRM2,SERPINE1 | 727 (24) |
| Raf | NA | group | NA | -1.22e+00 | 0.0e+00 | ANPEP,BCL2L11,CCND1,CDKN1A,ETV1,FOSL1,GRIN1,IER3,IFI16,JUN,MAFF,PLPP3,RET,SEMA4C | 749 (22) |
| elaidic acid | NA | chemical - endogenous mammalian | NA | -1.23e+00 | 1.0e-02 | ACAT2,ACSL3,CYB5B,DGAT1,DHRS3,FADS1,FDFT1,HMGCS1,HSD17B7,IDE,LIPH,LSS,PNLIPRP2,PRPF19,SCNN1A | NA |
| iron | NA | chemical - endogenous mammalian | NA | -1.24e+00 | 1.0e-02 | CCND1,CCNE1,CDKN1A,FTL,GADD45A,GADD45B,Mt1,NDRG1,NFYA,TFRC,UBE2D1 | 625 (22) |
| GW9662 | NA | chemical reagent | NA | -1.24e+00 | 0.0e+00 | AGER,ANGPTL4,CAV1,CCL5,CD83,CD86,CDKN1A,CEACAM1,GIPR,GPAM,HSPA5,KLF4,MID1IP1,NR1D1,RORA,SDC1,SREBF1,UCP2 | 646 (22) |
| SREBF1 | -6.60e-01 | transcription regulator | NA | -1.25e+00 | 1.0e-02 | ARF4,BHLHE40,CDKN1A,CXCL10,CYP27B1,ELOVL5,ELOVL7,FABP7,FADS1,FBXO32,FDFT1,GLP1R,GPAM,HK2,HMGCS1,HSPA1A/HSPA1B,HSPA5,IDH1,IL1R2,LEP,LSS,NFIL3,NR0B2,NR1H3,PPAT,SCARB1,Scd2,SERPINE1,SMPD1,SORBS3,SREBF1,TRIM63,UCP2,UCP3,ULK2,VGF | 671 (23) |
| RNF181 | -3.10e-01 | enzyme | NA | -1.25e+00 | 1.0e-02 | ARF6,DCLRE1A,ESR1,GREB1,PTP4A1,UGCG,ZNF385B | NA |
| H89 | NA | chemical drug | NA | -1.27e+00 | 0.0e+00 | ACE,AQP5,CCL5,CCND1,CD55,CD83,CD86,CDKN1A,COL2A1,CYP27B1,DUSP1,EGR2,EGR3,ESR1,EZH2,GJA1,HDAC1,JUN,NFIL3,NOS1,NR4A2,PDE3B,REN,SDC1,SERPINE1,SH2D2A,UCP2 | 724 (18) |
| FGF1 | -8.00e-02 | growth factor | NA | -1.28e+00 | 0.0e+00 | AKR1B1,AXIN2,CCND1,CDKN1A,DCAF8,DLL1,FZD1,FZD7,ICAM1,Irgm1,ITGAX,JUN,NDNF,NQO1,NR1H3,NR4A2,PMEPA1,PNLIPRP2,PXYLP1,TGFB2,TGM2,TH,THBS1,TIMP3,VEGFC | 814 (24) |
| THPO | NA | cytokine | NA | -1.28e+00 | 0.0e+00 | AURKA,CCND1,CCNE1,CISH,E2F4,EPSTI1,GCH1,HNF1A,ICAM1,IRF1,ITGA2B,JAK2,KLF4,MYCN,STAT1,STAT2,USP18,VDR | 619 (19) |
| ENG | 4.70e-01 | transmembrane receptor | NA | -1.29e+00 | 5.0e-02 | ELN,ITGA5,MMP19,PAK1,PDGFB,SERPINE1,THBS1 | NA |
| RXRA | -1.10e-01 | ligand-dependent nuclear receptor | NA | -1.29e+00 | 0.0e+00 | ABCA4,ACSL3,AHCY,ASNS,ATF4,Ccl6,CCND1,CD86,CDKN1A,CRYAA/LOC102724652,CUL4A,CXCL10,CYP27B1,DHRS3,ECT2,FLRT3,FLT3,FTL,GCHFR,IER3,IL20,IRF7,LSR,MATN4,MID1IP1,Muc1,MUC13,MYCN,NEDD9,NR0B2,NR1D1,NR1H3,OLR1,OSMR,PDGFB,RAMP2,RBPJL,REN,RET,RORA,RRP12,S100G,SATB1,SDC1,SFTPB,Slco1a4,SNAPC4,SREBF1,TEAD3,TGFB2,TH,THBD,TK1,TNFSF10,UCP3,VCAN,VDR | 755 (21) |
| IGFBP3 | 3.10e-01 | other | NA | -1.30e+00 | 2.0e-02 | BAD,CCL5,CDKN1A,COL2A1,ICAM1,SERPINE1,STAT1,TNC | NA |
| KMT2D | 1.00e-02 | transcription regulator | NA | -1.31e+00 | 1.0e-02 | ADGRG2,BTG3,CCDC91,CD55,ENO3,GLYCTK,HOPX,IRF1,IRF6,KLF4,LAMB3,METRNL,NT5E,OXR1,PPP1R26,PPP2R2B,RIOX2,SCARB1,SFXN4,SORD,STBD1,TCEAL1,TGM1,Tpm4,WDSUB1,XKRX,ZNF184,ZNF641 | 209 (7) |
| Ro41-5253 | NA | chemical reagent | NA | -1.31e+00 | 4.0e-02 | CDKN1A,IRF1,PLAT,TGFB2,THBD | NA |
| ZBTB16 | 4.30e-01 | transcription regulator | NA | -1.32e+00 | 1.0e-02 | ATF1,B4GALNT1,BMP7,CCND1,CD200R1,CD55,CD83,CD86,CDKN1A,CXCL10,CXCR3,DHRS3,EARS2,EGR2,F2R,FABP7,H6PD,ID3,IL12RB1,IRF6,ITGAV,KCNJ8,Klrk1,PBX1,PDGFB,POLD1,RORA,SATB1,SGMS2,TSC22D1 | 512 (7) |
| GJA1 | -7.10e-01 | transporter | NA | -1.32e+00 | 4.0e-02 | CCND1,CDKN1A,GJA1,GJC2,ICAM1,SKP2,THBS1 | NA |
| benzo(a)pyrene | NA | chemical toxicant | NA | -1.33e+00 | 0.0e+00 | ARHGEF6,BCL2L11,BRAF,BTG3,CDK2AP2,CDKN1A,ECT2,ERCC5,FGF9,FZD1,HK2,HSPA1A/HSPA1B,IER3,ING1,INHBB,JUN,LCP1,LDB2,MAD2L1,MAFF,MAP2K3,METTL21A,NQO1,NUMBL,PCNA,PPIF,SERPINE1,SFTPC,TAF6,TGFB2,THBS1,TXNRD1,XPA,ZWINT | 714 (22) |
| PURPL | NA | other | NA | -1.34e+00 | 1.0e-02 | CENPJ,CNTRL,DIO2,OAS2,TMPO | NA |
| CTR9 | -1.80e-01 | other | NA | -1.34e+00 | 1.0e-02 | EGR3,EPAS1,GREB1,Meis1,SDC1,TIAM1 | NA |
| PPP3CB | -9.10e-01 | phosphatase | NA | -1.34e+00 | 1.0e-02 | CDKN1A,FBXO32,GADD45A,RBL2,TRIM63 | NA |
| FOXC1 | 4.50e-01 | transcription regulator | NA | -1.34e+00 | 2.0e-02 | BCL2L11,COL2A1,DLL1,EFNB2,GBP1,GBP4,ICAM1,IFI35,IRF1,IRF6,ISG20,MX1,OAS2,SERPINE1,STAT1,STAT2,TGM1,TRIM68,TSC22D1,USP18,WNT5A | NA |
| IFN alpha/beta | NA | group | NA | -1.36e+00 | 0.0e+00 | ARHGEF10,BCL2L11,CCL24,CCL5,CCRL2,CD83,CD86,CLEC10A,CX3CL1,CXCL10,IFI16,IL15RA,IRF1,IRF7,Irgm1,ITGA2B,RNF213,SOCS1,STAT1,STAT2,TLR2,TLR3,TLR5,TNFSF10,TRIM21 | 624 (17) |
| miR-155-5p (miRNAs w/seed UAAUGCU) | NA | mature microRNA | NA | -1.37e+00 | 1.0e-02 | BCL2L11,CCND1,DNAJB1,FADS1,FGF7,FMNL2,JARID2,MLH1,MSH2,MSI2,MYO10,NT5E,PDLIM5,PLXND1,RAI14,SATB1,SERPINE1,SLC30A1,SOCS1,SYNE2,TNFRSF10A,TXNRD1,UBE2J1 | NA |
| let-7 | -6.00e-02 | microRNA | NA | -1.38e+00 | 0.0e+00 | ARID3A,AURKA,BCAT1,BOP1,CCND1,CCNF,CDC25A,CPED1,E2F4,EIF4A1,EZH2,FARP1,FOSL1,GMNN,GREB1,HK2,HMGA1,LEF1,MAD2L1,MCM3,MCM4,MYCN,NQO1,NR1H4,NXT2,PABPC4,PROM1,RIOX2,RRM2,RRP1B,SERPINE1,SKP2,STAT3,THBS1,TRIB1 | 720 (22) |
| TBX2 | NA | transcription regulator | NA | -1.38e+00 | 0.0e+00 | AURKA,BHLHE40,CDKN1A,ELK3,EZH2,MAD2L1,MCM4,NCAPG2,NFIL3,PHTF2,PLK1,PRC1,PRDM5,PRIM2,SMC2,TGFB2 | 574 (19) |
| JAK1/2 | NA | group | NA | -1.39e+00 | 1.0e-02 | BAIAP2,DGKG,FAM107A,GBP5,Ifgga2l1/RGD1309362,Ifi47,IRF1,IRF7,MX1,MYO5B,NPTXR,PSD,RPRML | 178 (7) |
| SMAD7 | 2.90e-01 | transcription regulator | NA | -1.39e+00 | 0.0e+00 | Acan,BCL2L11,BIRC2,BMP7,BZW2,CCL5,CCNE1,CDKN1A,CGREF1,COL2A1,CXCL10,DEPTOR,GADD45A,ICAM1,ID3,NET1,PCNA,PLAT,PMEPA1,PROM1,SERPINE1,SFTPC,TGFB2,TIMP3 | 659 (20) |
| TERT | -5.40e-01 | enzyme | NA | -1.39e+00 | 0.0e+00 | ASNS,CAV1,CCL24,CCL5,CCND1,CCNE1,CDKN1A,CX3CL1,CXCL10,ELK3,F2R,FRMD6,HOXB6,ICAM1,IFI16,IFI35,IFI44,IFIH1,IRF7,ISG20,ITGAV,JUP,KLF4,LGR5,LIPG,MGME1,MTHFD1L,MX1,NOP58,NSFL1C,Oas1b,OAS2,Oasl2,PARP1,PDGFC,PROM1,RRM2,SERPINB2,STAT3,TK1,TOX2 | 607 (22) |
| lysophosphatidylcholine | NA | chemical - other | NA | -1.39e+00 | 5.0e-02 | CCL5,CD86,FDFT1,GJA1,HMGCS1,ICAM1,JUN,LSS,NLRP3,OLR1,SCARB1,SERPINE1,SREBF1 | NA |
| U73122 | NA | chemical reagent | NA | -1.39e+00 | 0.0e+00 | AGT,ATF4,ATP2A2,CHRM1,HSPA5,ICAM1,NFATC1,NOS1,OXTR,PCNA | 623 (19) |
| TP73 | 1.00e-02 | transcription regulator | NA | -1.40e+00 | 0.0e+00 | ADAM10,ANGPTL4,AQP3,AQP5,ATG10,ATG4C,ATG7,ATM,AURKA,BCAR1,BCL2L11,BDKRB2,BHLHE40,BIRC2,BMP7,BRAF,Ccl6,CCNF,CD55,CD83,CDC42EP2,CDKN1A,CDKN1C,CLEC7A,COL18A1,CX3CL1,CXCL10,DCLRE1A,DHRS3,DLG5,ERCC5,FOCAD,GADD45A,GJA1,GRAMD4,HAGH,HAPLN3,HSPA1A/HSPA1B,HSPB8,HTATIP2,IER3,ITGA5,ITGAX,JAK2,KIFC3,LAMA5,LASP1,LCP1,LTBP1,LY6D,MICOS10-NBL1/NBL1,MISP,MLH1,MMP19,MTHFD1,MUTYH,MYCN,NAP1L3,NDRG1,PDGFB,PIGF,PKP2,PML,PNRC1,PRKDC,PROCR,RAB7B,RFX2,Serpinb6b,SERPINE1,SHROOM4,SLC4A3,SORBS3,SPINT1,SYNE2,TCEAL1,TFCP2L1,TGFB2,TH,THBS1,TIMP3,TLE2,TNFRSF10A,TSPAN1,UBE2C,UBE2D1,ULK2,VDR,VEGFC,WARS2,XRCC6,YBX1 | 692 (24) |
| RIGI | NA | enzyme | NA | -1.40e+00 | 0.0e+00 | CCL5,CD83,CXCL10,CXCL11,DLL1,GEM,ICAM1,IFI35,IFI44,IFIH1,IL15RA,IL18,IRAK2,IRF1,IRF7,ISG20,KLF4,MX1,SOCS1,STAT1,STAT2,THBS1,TLR3,TLR5,TNFSF10,USP18 | 311 (15) |
| NCOA2 | -6.40e-01 | transcription regulator | NA | -1.40e+00 | 0.0e+00 | ADORA1,APOC2,CCL5,CCND1,CDKN1A,CXCL10,GBP5,HMGCS1,HNF1A,IRF1,IRF7,KLF4,LIPC,LIPG,NQO1,NR1D1,NR1H3,NR4A2,NR4A3,PPP1R3B,RET,RORA,SFTPB,SREBF1,UCP3,VDR | 686 (21) |
| triptolide | NA | chemical drug | NA | -1.41e+00 | 4.0e-02 | APLNR,BAD,BIRC2,CAV1,CDKN1A,DUSP1,EFNB2,HK2,ICAM1,IER3,ITGA2,JUN,LEF1,MMP19,PCNA,SLC7A11,TLR2,TLR3,TNFSF10 | NA |
| AURKB | 4.00e-01 | kinase | NA | -1.41e+00 | 3.0e-02 | BLM,CDKN1A,DDB2,IER3,MCM3 | NA |
| VHL | 1.80e-01 | transcription regulator | NA | -1.41e+00 | 0.0e+00 | ATF4,AURKA,BCL2L11,BHLHE40,CA9,CAV1,CCND1,CDCP1,CDKN1A,CDKN1C,CLDN4,EPAS1,FTL,HK2,HNF1A,IER3,ITGA5,LOX,MAD2L1,NEDD9,NEK8,PCNA,PDGFB,RHOF,SKP2,TFRC,TH,TNFSF10,TRAF1,VEGFC | 655 (21) |
| SCX | 3.21e+00 | transcription regulator | NA | -1.41e+00 | 3.0e-02 | Acan,COMP,SCX,TIMP3,TNC | NA |
| TMEM165 | 2.00e-02 | other | NA | -1.41e+00 | 2.0e-02 | Acan,CHSY1,COL2A1,SERPINE1 | NA |
| EFNA3 | 5.00e-02 | kinase | NA | -1.41e+00 | 3.0e-02 | FOSL1,IRF1,IRF7,NT5E,PKP1,PLAT,TGM1,UBE2C | NA |
| EFNA2 | -4.70e-01 | kinase | NA | -1.41e+00 | 5.0e-02 | FOSL1,IRF7,NFIL3,NOS1,NT5E,PKP1,PLAT,TGM1,UBE2C | NA |
| BCL3 | -8.70e-01 | transcription regulator | NA | -1.42e+00 | 1.0e-02 | AGT,CCL5,CCND1,CD86,CXCL10,DUSP5,EGR2,ICAM1,IL19,IRF1,JUN,STAP2 | 715 (18) |
| imipramine blue | NA | chemical drug | NA | -1.44e+00 | 0.0e+00 | AURKA,CCND1,CCNF,CDC25A,FOXRED2,GADD45A,PCNA,PLK1,SKP2 | 475 (7) |
| TFEB | -9.30e-01 | transcription regulator | NA | -1.45e+00 | 0.0e+00 | ANAPC1,ARSB,AURKA,BCL3,CCL5,CCND1,CD55,CDC25A,CDCP1,CEP290,CHTF18,CNTRL,CUL4A,FJX1,FOSL1,GMNN,HDAC1,HMMR,HOPX,ICAM1,IL33,JUN,MAP1LC3A,MCM3,MCM4,MLH1,MYBL2,NCAPG2,NFIA,NRBF2,NUP62,ORC5,PCNA,POLD1,POLE2,PPAT,PRIM2,RAD51,RAD51C,RRM2,SMC2,SOCS1,TFEB,TMPO,TNFRSF21,TOP3A,TRAF1,UPP1,VRK1,XPO1,ZWINT | NA |
| sphingosine-1-phosphate | NA | chemical - endogenous mammalian | NA | -1.45e+00 | 1.0e-02 | ANGPT1,ATOH8,BDKRB2,CASZ1,CCL5,CCND1,CD83,CSF2RB,CXCL10,GALNT15,GBP5,ICAM1,IRF6,JUN,KCNH2,LEP,LIPC,PCSK6,PDGFB,SERPINE1,THBS1,VEGFC | 776 (20) |
| GNAI2 | 1.00e-02 | enzyme | NA | -1.45e+00 | 1.0e-02 | BHLHE40,CCND1,F2R,MLH1,PLCB3,PTPN1,STAT3 | NA |
| miR-92a-3p (and other miRNAs w/seed AUUGCAC) | NA | mature microRNA | NA | -1.45e+00 | 3.0e-02 | BCL2L11,CCND1,CCNE1,CDKN1A,CDKN1C,ITGA5,KLF4,RFFL | NA |
| PRKDC | -8.60e-01 | kinase | NA | -1.46e+00 | 0.0e+00 | ATM,CCND1,CDKN1A,EGR2,GREB1,NR1D1,PIM3,PLA1A,PLK1 | 712 (24) |
| EFNA4 | 6.60e-01 | kinase | NA | -1.46e+00 | 2.0e-02 | FOSL1,IRF1,IRF7,NT5E,PKP1,PLAT,TGM1,UBE2C | NA |
| sirolimus | NA | chemical drug | NA | -1.47e+00 | 4.0e-02 | AQP3,ASCL2,ASNS,ATF4,ATG7,AURKA,BCL2L11,BCL3,CCND1,CCNE1,CCNF,CD86,CDC25A,CDKN1A,DGAT1,EGR2,EIF4A1,EPRS1,FGF9,FSCN1,HDAC5,HK2,HSPA5,ICAM1,IDH1,IL33,IRF7,IRF9,JAK2,JUN,LEP,LGR5,LILRB4,MAP1LC3A,MAP4K5,MED12,mir-154,Mt1,MTHFD2,NCL,NLRP3,NR4A3,OAZ1,OSCAR,PARP14,PCNA,PDGFB,PEX2,PML,PRMT1,PROM1,PTP4A1,RPL9,RPS18,SERPINE1,SKIL,SLC12A5,SLC25A43,SLC3A2,SLC7A11,SLC7A5,SREBF1,STAT1,THBD,TMPO,TUBB2A,UCP2 | NA |
| GW3965 | NA | chemical reagent | NA | -1.47e+00 | 2.0e-02 | CAV1,CCL5,CD86,CHEK2,CIDEC,CXCL10,DUSP1,IER3,MERTK,MID1IP1,NR1D1,NR1H3,RAD51,Serpinb6b,SKP2,SREBF1,TRIB1,UGCG | NA |
| SLPI | NA | other | NA | -1.47e+00 | 2.0e-02 | CCL5,CCND1,CD86,ICAM1,LOX,NFKBIB | NA |
| propranolol | NA | chemical drug | NA | -1.48e+00 | 1.0e-02 | ACE,ATP2A2,DIO2,DUSP1,HK2,ICAM1,LEP,LGALS12,TH | 810 (22) |
| NR1H3 | -9.40e-01 | ligand-dependent nuclear receptor | NA | -1.49e+00 | 0.0e+00 | ACSL3,ADRB3,APOC2,AURKA,CCL24,CCL5,CD55,CDKN1A,CHEK2,CX3CL1,CXCL10,DIO2,FDFT1,GBP4,GPAM,IL12RB1,IRF7,KNL1,MERTK,MID1IP1,Mt1,NR0B2,NR1H3,NUSAP1,PLK1,PRC1,PRDM16,RAD51,REN,SCARB1,Scd2,SOCS1,SREBF1,TRIB1,UBE2C,VCAN,VEGFC | 909 (26) |
| ZNF281 | 4.30e-01 | transcription regulator | NA | -1.49e+00 | 1.0e-02 | BLM,CCL24,Ccl6,FANCG,GADD45A,IL20,LGR5,PROM1,RAD9A,XRCC4 | NA |
| RORC | NA | ligand-dependent nuclear receptor | NA | -1.49e+00 | 2.0e-02 | ASNS,B3GALT1,CCL5,CISH,CYP39A1,Cyp3a25 (includes others),ELOVL7,FDFT1,GADD45B,HK2,HSD17B7,IL12RB1,KCNK5,Mt1,NAT2,NLRP3,NOCT,POR,PPAT,PROCR,RORA,Scd2,SLC13A2,SLC7A5,Slco1a4,Sult1d1 | NA |
| PLK1 | 6.50e-01 | kinase | NA | -1.49e+00 | 0.0e+00 | ACKR3,BCL2L11,CDKN1A,DTX3L,ESR1,GMNN,IER3,IFI16,PARP9,PLK1,TGFB2,THBS1 | 673 (20) |
| NGFR | -1.80e-01 | transmembrane receptor | NA | -1.50e+00 | 2.0e-02 | CCND1,CCNE1,GRIA3,JUN,NR0B2,PCNA,PLAT,SERPINE1 | NA |
| E2F4 | 6.00e-01 | transcription regulator | NA | -1.50e+00 | 0.0e+00 | BCL2L11,CCND1,CCNE1,CDC25A,CDKN1A,CHEK2,CSTF1,DDX11,ECT2,EPAS1,FANCC,FDFT1,FGF7,GMNN,GOLT1B,HLTF,HMMR,ID3,MAD2L1,MCM3,MCM4,MLH1,MSH2,MTHFD1,MYBL2,MYCN,NCL,PCNA,PLK1,PLSCR1,POLA1,POLD1,PPP2R2B,PRC1,PRIM2,PRKDC,RAD51,RAD54L,RBL2,RRM2,SERPINE1,SLC3A2,SMC2,TK1,TMPO,UBE2C,ZSCAN12 | 535 (11) |
| PARP9 | -1.03e+00 | enzyme | NA | -1.50e+00 | 1.0e-02 | IFI44,IRF1,IRF7,OAS2,SP110,STAT1 | NA |
| SPHK1 | -4.50e-01 | kinase | NA | -1.51e+00 | 0.0e+00 | BCL2L11,BIRC2,CCL5,CCND1,CDKN1A,GCH1,ICAM1,IL33,JUN,SERPINE1,TRAF1 | 723 (19) |
| SP600125 | NA | chemical drug | NA | -1.52e+00 | 0.0e+00 | ACAT2,ADAMTS4,ANGPT1,BAD,BCL2L11,CCL5,CCND1,CD83,CD86,CDKN1A,CHAC1,CIDEC,CLDN4,CPM,CXCL10,CYP27B1,DDIT4L,DUSP1,FBXO32,FLRT3,GADD45A,GRB10,HAS1,HSPA5,ICAM1,IL18,ITGA2,JUN,LAMA5,MSH3,MTHFD2,NEDD9,NOL9,NPHS2,NR0B2,PARP1,PDGFD,PLCB3,PLSCR1,POLI,PROM1,Scd2,Serpinb6b,SERPINE1,SERPINH1,SOX7,SP110,SREBF1,THBS1,TNFRSF10A,TRIM63,VDR | 850 (25) |
| ADIPOQ | 2.30e-01 | other | NA | -1.54e+00 | 5.0e-02 | APOC2,BAD,BCL3,CCL5,CCND1,CDKN1A,CLEC10A,CXCL10,CXCL11,Cyp3a25 (includes others),DGAT1,DUSP1,FZD1,FZD7,FZD9,ICAM1,IL18,Klrk1,LEP,NR1H3,PCNA,SREBF1,STAT3,TRAF1,UCP2,UCP3,VEGFC,WNT5A,WNT5B,WNT9B | NA |
| IFNL3 | NA | cytokine | NA | -1.54e+00 | 0.0e+00 | IFIH1,ISG20,MX1,Oas1b,SOCS1,STAT1,TLR2,TLR3,USP18 | 701 (19) |
| SNCA | -1.40e-01 | enzyme | NA | -1.55e+00 | 0.0e+00 | AGT,BAIAP2,BHLHE40,CABP1,CARMIL1,CCBE1,CDC42EP3,CDH9,CHAC1,CHGB,CLEC7A,DGKG,DHRS3,DLGAP2,DMXL2,DUSP1,ERC2,FABP7,FAM107A,FBXO32,FGF13,GADD45A,GBP5,GRAMD1B,HSPA5,Ifgga2l1/RGD1309362,Ifi47,IRF1,IRF7,ITGAX,KCTD6,KLF4,MAP1LC3A,MAP2K3,METRNL,MX1,MYO5B,NLRP3,NPTX2,NPTXR,NQO1,NR4A2,PBX1,PDZRN3,PLSCR1,PLXNC1,PRKCD,PSD,RET,RPH3A,RPRML,SERPINE1,SH2D5,SLC10A4,SNX22,SPAG8,SV2B,TH,TLR2,VAT1L | 788 (19) |
| lipoteichoic acid | NA | chemical - endogenous non-mammalian | NA | -1.55e+00 | 2.0e-02 | BCL2L11,CD83,CD86,CXCL10,GLRB,ICAM1,NLRP3,NR4A2,NR4A3,TLR2,TLR3,TOLLIP | NA |
| RIPK2 | -1.60e-01 | kinase | NA | -1.57e+00 | 0.0e+00 | CCL5,CD86,CXCL10,DGAT1,DHX58,GBP1,GBP4,HELZ2,ICAM1,IFI35,IFI44,IFI44L,IFIH1,IL33,IRF7,IRF9,MARCKSL1,MEFV,MX1,MYCN,NR1H3,OAS2,PDE4B,PNPLA2,SREBF1,STAT1,STAT2,TNFSF10,TRAF1,TRIM21,USP18 | 760 (18) |
| YY1 | 3.20e-01 | transcription regulator | NA | -1.57e+00 | 3.0e-02 | ARID3A,ATF4,AURKA,BCL2L11,CDKN1A,CDKN1C,CFTR,EGR2,GBP1,GFER,HSPA5,ID3,ID4,IL1R2,KLF4,LRP2,MAD2L1,MCM4,MPG,PAWR,PCNA,PDGFD,PLK1,POLA1,POLK,PRC1,PROX1,RAD51,RLIM,SCARB1,SIM1,SLC23A2,TGFB2,TGM2,TNFRSF10A,TRA2A,VEGFC | NA |
| SPARC | -7.00e-02 | other | NA | -1.58e+00 | 0.0e+00 | ABCC4,ATM,BHLHE40,BLM,CIDEC,CLDN4,ELMOD3,IRF7,JAK2,LEF1,MAP2,MSH2,NDRG1,NIPAL1,POLE2,SERPINE1,SLC7A11,STAT1,STAT3,THEM5,TMC5,UBLCP1 | 688 (22) |
| ibrutinib | NA | chemical drug | NA | -1.59e+00 | 1.0e-02 | ASNS,ATP6V1E1,CD86,DHRS3,EIF4E,EPAS1,GNL3,HES6,HK2,MCM4,NECTIN1,NIP7,PLK1,RILP,RRP12,SLC2A5,SLC38A1,SORD,TBRG4,TGFBR3,UGCG | NA |
| STX18 | 3.30e-01 | transporter | NA | -1.61e+00 | 0.0e+00 | ALS2,ANPEP,ARF6,BCL3,CEP131,CNTRL,DDB2,EZH2,FANCC,FBN2,LAMC2,MPG,PDE4B,PMEPA1,POLD1,SDC1,SERPINE1,TAF6,TNC | NA |
| IFNG | NA | cytokine | NA | -1.62e+00 | 0.0e+00 | ACE,ADGRA1,ADGRG2,ADORA1,AFMID,AGER,AGT,AHCY,ANGPTL4,ARAP2,ASNS,ATF4,ATM,ATP2A2,BCL2L11,BCL3,BIRC2,CABP7,Casp12,CAV1,CCL5,Ccl6,CCND1,CCRL2,CD200,CD55,CD83,CD86,CDC25A,CDKN1A,CEACAM1,CENPJ,CFTR,CHAC1,CISH,CLEC10A,CLEC7A,CLIC4,CLIC5,CNR1,CSE1L,CSF2RB,CX3CL1,CXCL10,CXCL11,Cxcl3,CXCR3,DDB2,DLL1,DTX3L,DUSP1,DUSP5,DUSP9,E2F4,EFNB2,EGR2,EGR3,ELN,EPOR,EXT1,F11R,F2R,FAM107A,FGF12,FMNL2,FTL,FZD1,GADD45B,GBP1,GBP4,GBP5,GCH1,GCHFR,GJA1,GMPR,GPR146,GPR158,GPR83,GPRC5B,GSDMD,H6PD,HK2,HLA-G,HMGA1,HMGCS1,HSPA1A/HSPA1B,HSPA5,ICAM1,IDE,IDH1,IER3,IFI16,IFI35,IFI44,IFI44L,Ifi47,IFIH1,Igtp,IL12RB1,IL15RA,IL18,IL19,IRAK2,IRF1,IRF7,IRF9,Irgm1,ISG20,ITGA5,ITGAV,ITGAX,JAK2,JUN,KCNJ1,KLF4,Klrk1,KNL1,LAMC2,Ldha/RGD1562690,LEP,LOX,MAFF,MAP2,MARCKSL1,MCM4,MEFV,MERTK,METRNL,mir-154,MRAS,MSH2,Mt1,MTHFD2,MX1,MYCN,NEDD9,NFKBIB,NLRP3,NOS1,NQO1,NR1D1,NR4A3,Oas1b,OAS2,Oasl2,OLR1,P2RY14,PARP14,PARP9,PDE3B,PDGFB,PDGFC,PENK,PIM3,PLSCR1,PML,POLE2,PRKCD,PROM1,PTPN1,PTPRN,RAB20,RTP4,SCARB1,SCLY,SCNN1A,SCNN1B,SCNN1G,SDC1,SDCCAG8,SEC61A1,SEMA4A,SERPINE1,SERPINH1,SKP2,SLC14A1,SLC7A11,SLC7A5,SLC9A3,SLFN5,SOCS1,SOCS2,SP110,SREBF1,SRP54,STAT1,STAT2,STAT3,STX11,TFRC,TGFB2,TGFBR3,TGM1,THBS1,TIMP3,TLR2,TLR3,TLR5,TNFRSF10A,TNFSF10,TRIM21,UBA2,UBE2C,UBE2D1,UCP2,USP18,VDR,VEGFC,WNT5A,ZNF81 | 747 (18) |
| SB 216763 | NA | chemical drug | NA | -1.62e+00 | 3.0e-02 | AXIN2,BHLHE40,CCND1,DLG2,FSCN1,NR4A2,NR4A3,SREBF1,TNFSF10 | NA |
| miR-30c-5p (and other miRNAs w/seed GUAAACA) | NA | mature microRNA | NA | -1.63e+00 | 0.0e+00 | ADAMTS15,ADPGK,ANPEP,ATP2A2,CCND1,CDCP1,CEP72,CHD1,CPNE8,ELMOD2,GALNT7,IDH1,ITGA2,JUN,MBNL1,MYO10,NCL,NT5E,PDGFB,PTGFRN,RAD23B,SLC38A1,SLC7A11,STX7,TXNDC5,UBE2I,VCAN,WNT5A | NA |
| emactuzumab | NA | biologic drug | NA | -1.63e+00 | 0.0e+00 | DHX58,GBP4,IRF9,SOCS1,STAT1,STAT2 | NA |
| calyculin A | NA | chemical toxicant | NA | -1.63e+00 | 2.0e-02 | CCND1,CCNE1,CD200R1,CDKN1A,NR4A3,TGM2 | NA |
| MAP2K6 | -3.70e-01 | kinase | NA | -1.64e+00 | 0.0e+00 | ATP2A2,CCND1,CD83,CD86,CDKN1A,CXCL10,ESR1,IRF9,JUN,OSCAR,RGS7,STAT1,TNFSF10,VDR | 675 (20) |
| IRF9 | -7.80e-01 | transcription regulator | NA | -1.64e+00 | 0.0e+00 | CXCL10,GBP1,HELZ2,Ifi47,IL18,IRF1,IRF7,ISG20,MX1,OAS2,Oasl2,PARP14,RTP4,SLFN13,SOCS1,STAT1,STAT2,STAT3,TNFSF10,USP18 | 632 (18) |
| TFRC | 8.20e-01 | transporter | NA | -1.65e+00 | 1.0e-02 | ATF4,BCL2L11,CDKN1A,CHAC1,ERFE,FTL,GADD45A,GSTT2/GSTT2B,HK2,HSPA5,JUN,SOX11,STC2,TGFB2,TNFSF10 | NA |
| THZ1 | NA | chemical drug | NA | -1.65e+00 | 1.0e-02 | ADAMTSL2,CLDN15,COMP,CSRP2,DIO2,GEM,HSPA1A/HSPA1B,LOX,LOXL3,MICOS10-NBL1/NBL1,PMEPA1,SDC1,SERPINE1,THBS1,TIAM2,TMEM119,TRAF1,TRERF1,VCAN | NA |
| N-acetyl-L-cysteine | NA | chemical drug | NA | -1.65e+00 | 0.0e+00 | ASCC1,ATF4,BCL2L11,BIRC2,CAV1,CCL5,CCND1,CD86,CDKN1A,CFTR,CHRNA9,CXCL10,DUSP1,FBXO32,GJA1,GNL3,HK2,HSPA5,ICAM1,IL18,IRAK4,JUN,MAP1LC3A,NFATC1,NLRP3,NQO1,PARP1,PCNA,PPRC1,PRKDC,SERPINE1,SLC16A1,THBD,TNC,TNFRSF10A,TRIM63,VEGFC | 774 (21) |
| CD40LG | -1.40e-01 | cytokine | NA | -1.66e+00 | 0.0e+00 | ARSB,ASCC3,BIRC2,BTG3,CCL5,CD83,CD86,CDKN1A,CXCL10,CXCR3,DDX42,DUSP1,DUSP5,FSCN1,GADD45A,GCH1,HK2,HSPA1A/HSPA1B,ICAM1,ID3,IFI44,IL12RB1,IRF1,JAK2,JUN,MAP2K3,MARCKSL1,MSH2,MX1,NET1,NFKBIB,NR4A3,ORC5,PAWR,PEX14,PML,POLA1,PRKDC,PTPN1,SERPINE1,SOCS1,STAT1,STAT3,TFAP4,TFRC,TGM2,TNFSF10,TNIP1,TRADD,TRAF1,WNT5A,XRCC6 | 734 (15) |
| P2RY2 | 1.00e-01 | G-protein coupled receptor | NA | -1.66e+00 | 1.0e-02 | CCND1,CDKN1A,ICAM1,JUN,OGG1,SCNN1A,SERPINE1 | 633 (18) |
| ALDH2 | 1.70e-01 | enzyme | NA | -1.66e+00 | 3.0e-02 | ATF4,MTHFD2,PARP1,SHMT1,SLC3A2,SLC7A11,SLC7A5 | NA |
| PELP1 | 4.40e-01 | other | NA | -1.66e+00 | 3.0e-02 | ANGPTL4,ASNS,BAD,CCND1,CDKN1A,EDEM2,FBN2,GREB1,GSTT2/GSTT2B,IFI44,KAT2B,LCP1,LEP,MLPH,MRAS,NDRG1,P3H2,TGM2,TOX2 | NA |
| NUP98-DDX10 | NA | fusion gene/product | NA | -1.67e+00 | 2.0e-02 | ANGPT1,Ccl6,CLEC7A,GADD45B,HOXB6,HOXB7,Meis1,MYCN,REN | NA |
| TINCR | NA | other | NA | -1.67e+00 | 1.0e-02 | ALOXE3,ATF4,CHAC1,EPAS1,FTL,PDGFB | NA |
| ECSIT | -1.80e-01 | transcription regulator | NA | -1.67e+00 | 2.0e-02 | BCL3,CD83,IER3,IRF7,NR4A2,TRAF1 | NA |
| EPO | NA | cytokine | NA | -1.69e+00 | 0.0e+00 | ADAMTS10,ATOH8,BCL2L11,BCL3,BLM,BZW2,CD86,CDKN1A,CISH,CPSF3,EPOR,ERFE,IDE,IL18,IL20,JUN,KAT2B,L3MBTL1,LCP1,MID1IP1,mir-154,MLH1,NFATC1,NMU,PCNA,PDLIM2,PRKCB,PRKCD,REN,RNF128,SKP2,SMARCD2,SOCS1,SOCS2,STAT3,STRADB,TFRC,TNFSF10,TPT1,UCP2,UGCG,VEGFC,YBX1 | 712 (18) |
| RNF31 | -6.00e-02 | enzyme | NA | -1.70e+00 | 0.0e+00 | ACE,ADORA1,AURKA,C8orf44-SGK3/SGK3,CCL5,Ccl6,CCND1,CXCL10,Cxcl3,EGR3,ESR1,GREB1,IL15RA,IL18,IL19,IL1R2,IL33,SCARB1 | 728 (15) |
| TMPRSS2-ERG | NA | fusion gene/product | NA | -1.70e+00 | 5.0e-02 | CHAC1,CREB3L1,DHRS3,DPYSL5,FOXP2,FSCN1,GPRC5B,HCAR1,ID3,IFI44,PLAT,SLC7A11,STC2,THBS1,TLR2,VEGFC,WNT5B | NA |
| nitrofen | NA | chemical toxicant | NA | -1.71e+00 | 0.0e+00 | APLNR,CLIC4,EPAS1,GLP1R,KCNJ8,SCNN1A,SCNN1G,TGFBR3,TIMP3 | NA |
| GIP | NA | other | NA | -1.71e+00 | 3.0e-02 | ACE,CCL5,CXCL10,GBP5,Ifi47,PRDM16,RFX6,SERPINE1,STX11,UCP2 | NA |
| FZD9 | 9.70e-01 | G-protein coupled receptor | NA | -1.71e+00 | 0.0e+00 | CCL5,CXCL10,IFI16,IFI44,IRF7,Oasl2,STAT1 | 413 (7) |
| ritonavir | NA | chemical drug | NA | -1.72e+00 | 3.0e-02 | ACAT2,AXIN2,CARS1,CEP135,CEP70,ECT2,FDFT1,HMMR,ICAM1,LEP,NAGK,RGS10,SLC39A10,SREBF1,TGIF2,TMPRSS4,TWF2,USP18,WNT5B | NA |
| IFNA14 | NA | cytokine | NA | -1.72e+00 | 0.0e+00 | CXCL10,CXCL11,IFIH1,IRF7,ISG20,MX1 | 190 (8) |
| N-ethyl-N-nitrosourea | NA | chemical toxicant | NA | -1.73e+00 | 0.0e+00 | CCL24,CCL5,CDKN1A,CX3CL1,ICAM1,IFI35,IFI44,IFIH1,IRF7,ISG20,Mt1,Oas1b,OAS2,Oasl2,TGM2 | NA |
| chloropromazine | NA | chemical drug | NA | -1.76e+00 | 2.0e-02 | ACAT2,CD83,FDFT1,HMGCS1,IL18,LSS,NR4A2,NR4A3 | NA |
| PLAUR | 4.30e-01 | transmembrane receptor | NA | -1.76e+00 | 3.0e-02 | ATM,CCL5,CCND1,FOSL1,JUN,PRKDC,SOCS1,XRCC6 | NA |
| PROC | -3.60e-01 | peptidase | NA | -1.77e+00 | 0.0e+00 | ACE,AGT,ANGPT1,BIRC2,ICAM1,PCNA,PROCR,SERPINE1,THBD,THBS1,TLR2 | 721 (18) |
| mevalonic acid | NA | chemical - endogenous mammalian | NA | -1.77e+00 | 1.1e-01 | CD55,ICAM1,PLAT,SCARB1,SERPINE1,SREBF1 | NA |
| CpG ODN 2006 | NA | chemical reagent | NA | -1.78e+00 | 0.0e+00 | ACTG1,APPL2,ATM,CCL5,CD55,CD86,CXCL10,CXCL11,DLL1,EPSTI1,FLT3,GBP1,GBP4,GBP5,HDAC5,ICAM1,IFI35,IFI44,IFI44L,IFIH1,IL15RA,IRF7,IRF9,ISG20,MLH1,MX1,PDE4B,PDE4D,PRKCB,PRKDC,SEMA4B,STAT1,TFRC,TLR5,TNFSF10,TNFSF18,TNIP1,TRAF1,USP18,XRCC6 | 326 (14) |
| topotecan | NA | chemical drug | NA | -1.78e+00 | 0.0e+00 | ARHGAP42,ATF4,AURKA,BCL3,CARNMT1,CCNE1,CD200,CD83,CDC25A,CDKN1A,CEBPZ,CHD1,CSTF1,CXCL10,DUSP5,EGR3,ENTPD7,EPOR,FZR1,GADD45B,Gar1,GCH1,GOLT1B,HMMR,HSPA1A/HSPA1B,ICAM1,IRF1,ITGA2,JMJD1C,JUN,KDELR2,MAP2K3,MAP2K5,MARCKSL1,MSH2,MYBL2,MYCN,NFIA,PDE4B,PIK3R5,PLK1,RDH13,SETD6,SLC7A5,SOCS1,TIAM1,UNC5D,VCL,YBX1 | 630 (16) |
| IRS1 | -3.00e-01 | enzyme | NA | -1.81e+00 | 9.0e-02 | CCND1,EFNB2,FBXO32,FMO1,GJA1,GLRB,KLF4,LEP,MYBL2,PLPP3,PRDM16,SREBF1,TRIM63,UCP2,UCP3,WNT5A | NA |
| PRL | 0.00e+00 | cytokine | NA | -1.82e+00 | 0.0e+00 | ATP2A2,CAV1,CCND1,CDKN1A,CISH,CXCL10,CXCL11,Cxcl3,DHX58,DTX3L,EPSTI1,ESR1,GMPR,GNRHR,HELZ2,HSD17B7,ICAM1,ID3,IDE,IER3,IFI35,IFI44,IFI44L,IFIH1,IGFALS,IRF1,IRF7,IRF9,JAK2,JUN,MAGED1,MICOS10-NBL1/NBL1,NEDD9,OAS2,PAQR7,PAQR8,PARP14,PCNA,PDIA4,PDK2,PENK,PIM3,PLAT,PLSCR1,POLR1C,PPRC1,PROX1,PTGFR,REC8,SCARB1,SDC1,SOCS1,SOCS2,SP110,STAT1,STAT2,STAT3,STC2,TSC22D1,USP18,VDR | 808 (19) |
| poly rI:rC-RNA | NA | biologic drug | NA | -1.82e+00 | 0.0e+00 | Abi3bp,ACSL3,ADAM10,APOL2,ATF4,BCL3,BIRC2,CARS1,Casp12,CCL5,CD200,CD83,CD86,CDKN1A,CEACAM1,CLEC7A,CX3CL1,CXCL10,CXCL11,CYP27B1,DCLRE1A,DHX58,DIO2,DLL1,DTX3L,DUSP1,DUSP5,EIF3B,EIF5A,ELMOD2,EPSTI1,ERFE,EXT1,FOSL1,GADD45B,Gar1,GBP1,GBP4,GBP5,GCH1,GEM,GPHN,H2-T24,HAS1,HELZ2,HLA-G,HSPA5,ICAM1,IFI16,IFI35,IFI44,IFI44L,IFIH1,Igtp,IL15RA,IL18,IL33,IRAK2,IRF1,IRF7,IRF9,Irgm1,ISG20,ITGA5,ITGAX,JAK2,JUN,KLF4,Klrk1,LIPG,LTA4H,MAFF,MERTK,mir-154,MOV10,MRAS,MX1,NCOA7,NEDD9,NFIL3,NLRP3,NOP56,NOP58,NR4A2,NR4A3,Oas1b,OAS2,Oasl2,OLR1,PABPC4,PARG,PARP14,PIM3,PIWIL4,PLSCR1,PML,PRKCD,PTBP2,RNF4,RNPC3,RTP4,SCARB1,SERPINB2,SERPINE1,SLC25A28,SLFN13,SLFN5,SOCS1,SP110,STAT1,STAT2,THBD,THBS1,TIAM2,TLR2,TLR3,TLR5,TNFRSF10A,TNFRSF21,TNFSF10,TNIP1,TOLLIP,TRAF1,TRIM27,TRIM6-TRIM34,TRPV1,UCKL1,USP18,VEGFC,WNT5A,XPO1 | 559 (15) |
| glutamine | NA | chemical - endogenous mammalian | NA | -1.86e+00 | 0.0e+00 | ASNS,ATF4,ATG7,BCAT1,BCL2L11,CARS1,CCND1,CDKN1A,DUSP1,GADD45A,HSPA1A/HSPA1B,HSPA5,ICAM1,IDH1,JUN,KLF4,OAZ1,PARP1,PCNA,PDGFB,PROM1,SLC16A1,THEM5 | 640 (21) |
| MMP2 | 4.80e-01 | peptidase | NA | -1.86e+00 | 0.0e+00 | CCL5,Ccl6,CCND1,CDKN1A,COL18A1,CSF2RB,CX3CL1,IRF7,JAK2,NR1H3,PDK2,SCARB1,SOCS1,TYK2 | 671 (16) |
| AS1842856 | NA | chemical reagent | NA | -1.86e+00 | 0.0e+00 | Acan,BCL2L11,CCL5,CDKN1A,COL2A1,CXCL10,FBXO32,ICAM1,TNFSF10,TRIM63 | NA |
| IFNK | NA | cytokine | NA | -1.89e+00 | 0.0e+00 | CD83,CD86,CXCL10,CXCL11,IFIH1,IRF1,MX1,STAT1,TLR3 | 457 (15) |
| TNK1 | 1.70e-01 | kinase | NA | -1.89e+00 | 0.0e+00 | IFI16,IFIH1,IRF7,ISG20,Oas1b,OAS2,TNFSF10 | 194 (10) |
| telmisartan | NA | chemical drug | NA | -1.89e+00 | 1.2e-01 | AGT,APLNR,CLEC10A,ICAM1,ITGAX,LEP,NR4A2,PRMT1 | NA |
| PF543 | NA | chemical drug | NA | -1.89e+00 | 1.3e-01 | Acan,ADAMTS4,DIO2,FGR,ITGAX,LOX,TNC | NA |
| NPY | 7.80e-01 | other | NA | -1.89e+00 | 2.0e-02 | CRY1,CRY2,DIO2,GAL,LEP,MAP2K3,NUDT12,PNPLA2,TH,TTC7A,UCP3 | NA |
| mir-96 | NA | microRNA | NA | -1.90e+00 | 0.0e+00 | IFI44L,JUP,OAS2,RPH3AL,RTP4,SLC30A1,SLC39A7,SLFN5,SP110,SYTL4 | NA |
| EFNA1 | -1.20e-01 | other | NA | -1.91e+00 | 3.7e-01 | FOSL1,IRF7,NT5E,PKP1,PLAT,TGM1,UBE2C | NA |
| let-7a-5p (and other miRNAs w/seed GAGGUAG) | NA | mature microRNA | NA | -1.92e+00 | 4.2e-01 | ADAMTS15,ANAPC1,CCND1,CCNE1,CDC25A,COIL,DSP,HMGA1,MTRR,NF2,NQO1,PDGFB,RPP38,SLC38A1,STAT3,TGFBR3,THBS1,VCAN | NA |
| miR-29b-3p (and other miRNAs w/seed AGCACCA) | NA | mature microRNA | NA | -1.92e+00 | 1.0e-02 | ADAMTS15,ANGPTL4,AXIN2,BCL2L11,CAV2,CCND1,HDAC4,KLF4,LEP,MLF1,MYBL2,NAV3,PDGFB,STAT3,TUBB2A,VCAN | NA |
| AGO1 | -3.60e-01 | translation regulator | NA | -1.93e+00 | 6.0e-02 | BCL2L11,CDKN1A,GREB1,TFAP4 | NA |
| mir-154 | 1.04e+00 | microRNA | NA | -1.93e+00 | 3.3e-01 | ADAMTS1,BCL2L11,CCND1,STAT3 | NA |
| OGA | NA | enzyme | NA | -1.93e+00 | 0.0e+00 | ABLIM1,ACTG1,ACTN4,ADGRG2,APOC2,BRAF,CAV1,CCBE1,Ccl6,CCND1,CD55,CD86,CDKN1A,CEACAM1,CSF2RB,CXCR3,DAGLB,EFNB2,EGR2,EPHB6,FABP7,FDFT1,FGF13,FGF9,FSCN1,GADD45A,GALNT7,GAS1,GFOD1,GTF2F2,GTF2IRD1,HIVEP2,HMGCS1,HSD3B7,IL18,ITGA2,JUN,LEP,LIPC,LSS,MICALL2,MYO10,NDUFA5,NFKBIB,PLIN3,PLPP3,PROM1,Scd2,SOCS1,SOCS2,STAT1,STAT2,TGFBR3,THBS1,TIMP3,TNC,TRADD | 682 (20) |
| FTO | -3.00e-01 | enzyme | NA | -1.94e+00 | 2.0e-02 | CCND1,HSPA1A/HSPA1B,ICAM1,JUN,LEP,PDE4B,PDGFC,SAMD4A | NA |
| mir-25 | NA | microRNA | NA | -1.94e+00 | 4.6e-01 | BCL2L11,CDKN1A,GADD45A,ITGA5 | NA |
| IRS2 | -2.00e-01 | enzyme | NA | -1.95e+00 | 5.2e-01 | CCND1,LEP,MX1,SREBF1 | NA |
| IFNA21 | NA | cytokine | NA | -1.95e+00 | 3.0e-02 | CXCL10,CXCL11,IFIH1,MX1 | NA |
| IFNA10 | NA | cytokine | NA | -1.96e+00 | 3.0e-02 | CXCL10,CXCL11,IFIH1,MX1 | NA |
| IFNA5 | NA | cytokine | NA | -1.96e+00 | 3.0e-02 | CXCL10,CXCL11,IFIH1,MX1 | NA |
| IFNA7 | NA | cytokine | NA | -1.96e+00 | 3.0e-02 | CXCL10,CXCL11,IFIH1,MX1 | NA |
| IFNA6 | NA | cytokine | NA | -1.96e+00 | 3.0e-02 | CXCL10,CXCL11,IFIH1,MX1 | NA |
| IFNA16 | NA | cytokine | NA | -1.96e+00 | 3.0e-02 | CXCL10,CXCL11,IFIH1,MX1 | NA |
| IFIH1 | -6.90e-01 | enzyme | NA | -1.96e+00 | 1.5e-01 | CCL5,CISH,CXCL10,IFI44L,IRF7,OAS2,USP18 | NA |
| CTSB | 8.00e-02 | peptidase | NA | -1.96e+00 | 2.7e-01 | ATM,CCND1,PRKDC,XRCC6 | NA |
| CTNS | -3.60e-01 | transporter | NA | -1.96e+00 | 0.0e+00 | ATF4,HSPA5,RILP,TFEB | NA |
| ISGF3 | NA | complex | NA | -1.96e+00 | 1.0e-02 | IFIH1,IRF1,IRF7,MX1,TNFSF10 | NA |
| IGF2BP1 | 2.60e-01 | translation regulator | NA | -1.96e+00 | 3.0e-02 | ASCL2,AXIN2,BIRC2,CDKN1A,GADD45A,SERPINH1,TNC | NA |
| dasatinib | NA | chemical drug | NA | -1.96e+00 | 3.0e-02 | CDKN1A,CXCL10,NHEJ1,PAWR,RAD51,SCARB1,SREBF1 | NA |
| mir-3622 | NA | microRNA | NA | -1.96e+00 | 4.0e-02 | CCND1,CDKN1A,GADD45A,GADD45B | NA |
| PTGS1 | -1.70e-01 | enzyme | NA | -1.96e+00 | 1.8e-01 | ANGPT1,CFTR,GEM,GJA1,NRG1,OXTR | NA |
| SESN2 | 5.20e-01 | enzyme | NA | -1.97e+00 | 7.0e-02 | ATF4,HSPA5,SCARB1,THBS1 | NA |
| lithocholic acid | NA | chemical - endogenous mammalian | NA | -1.97e+00 | 4.2e-01 | APOC2,CD86,CHAC1,LRP2,Slco1a4 | NA |
| IFNA8 | NA | cytokine | NA | -1.98e+00 | 3.0e-02 | CXCL10,CXCL11,IFIH1,MX1 | NA |
| MTM1 | -3.70e-01 | phosphatase | NA | -1.98e+00 | 1.1e-01 | FBXO32,MAP1LC3A,STAT3,TRIM63 | NA |
| ZNF503 | 4.80e-01 | other | NA | -1.98e+00 | 2.1e-01 | LRAT,MERTK,PENK,PLXND1 | NA |
| HNF4A | -7.20e-01 | transcription regulator | NA | -1.98e+00 | 0.0e+00 | ABCB10,ABHD10,ABHD6,ABT1,ADCY10,AGT,AGXT2,AKR1B1,Akr1b7,ALS2,ANKRA2,ANPEP,AP3M1,APOC2,AQP3,ARMT1,ASNS,ATF4,ATG4C,ATP10A,AXIN2,BAD,BCAR1,BCS1L,BMP7,Btnl4/Btnl6,C2orf42,CAV1,CCDC170,CCDC90B,CCND1,CCNE1,CCP110,CD55,CDC25A,CDC42EP2,CDC42EP3,CDK2AP2,CDKN1A,CDKN2AIPNL,CEACAM1,CHEK2,CIAO1,CIDEC,CLDND1,CPED1,CRY1,CUTC,DAAM1,DCAF8,DDX27,DHX8,DNAJC28,DPH5,DTX3L,DUSP19,E2F4,EAF1,ECD,ELMOD3,ERCC5,F11R,FDX1,FGF13,FGF7,Fhod1,FIG4,FLOT1,FMO1,FN3KRP,FOXJ3,FTSJ1,FUT10,FYCO1,FZD1,GADD45B,GAS1,GCHFR,GDAP2,GFER,GNL3,GOLGA4,GOLT1B,GPR146,GRB14,GSTCD,GYG1,HDAC8,HIKESHI,HLA-G,HNF1A,HSPA5,HSPH1,HYAL3,IMPA1,INVS,IRF6,ISY1-RAB43,ITGA2,ITGA5,ITGAV,JUN,KLC4,LAMB3,LAMC2,LARS2,LDAH,LGR5,LIPC,LRSAM1,LSR,LTA4H,MAP2K5,MCM3,MDFI,MGME1,MID1IP1,mir-154,MIS18BP1,MLH1,MON1B,MOV10,MRPL34,MRPS12,Mt1,MTHFD1,MTRF1,MUTYH,NDRG1,NDUFA5,NF2,NFYA,NIPAL1,NR0B2,NR1D1,NR1H3,NR1H4,NUAK2,NUP62,NXT2,ORC3,OSCAR,OSMR,P2RY14,PARP9,PATJ,PCNA,PDK2,PEX12,PKP2,PLD2,PLSCR1,POLR1C,POP5,POR,PPP1R10,PPP1R3B,PRCP,PRDM16,PRDM5,PRELID3B,PRMT1,PROM1,PTGFR,PTPRN,PUS3,RAB30,RAD51,RAI2,RASSF1,RBL2,RIOK3,RIOX2,RMND1,RNGTT,RORA,RPS18,RPS6KC1,RSPH3,RTCB,RTN4IP1,S100G,SARS2,SCARB1,SDC1,SERPINE1,SKP2,SLC22A8,SLC25A40,SLC26A1,SLC31A1,SLC35A5,SLC38A1,SLC39A7,Slco1a4,SMC2,SPATA2,SREBF1,SRP54,SSTR1,STAT1,STK24,STOML1,STRAP,STX17,SUPT3H,SYTL4,TACO1,TADA3,TAF6,TAOK3,TBCK,TDRKH,TEAD3,TERF2IP,TFAP4,TFRC,TIMM9,TIMP3,TMEM161A,TMEM43,TMTC4,TNC,TOR2A,TRIM15,TRMT1L,TRMT6,TXNRD1,UCP2,UROS,UTP3,VCL,VEGFC,WARS2,WASHC3,WDFY2,WDR12,XPA,XPNPEP3,XPO1,XRCC4,YBX1,ZFYVE19 | 915 (25) |
| DSP | 1.28e+00 | other | NA | -1.98e+00 | 1.0e-01 | AXIN2,GJA1,JUP,PKP1 | NA |
| RPL22 | 1.30e-01 | translation regulator | NA | -1.98e+00 | 2.0e-02 | ATF4,BCL2L11,CDKN1A,HSPA5 | NA |
| mocetinostat | NA | chemical drug | NA | -1.98e+00 | 1.4e-01 | CXCL10,PDGFC,SERPINE1,UNC5C | NA |
| PROCR | 9.00e-01 | other | NA | -1.98e+00 | 1.9e-01 | ANGPT1,CCND1,GBP4,ICAM1 | NA |
| COL5A1 | 2.90e-01 | other | NA | -1.98e+00 | 3.7e-01 | Acan,Gm12854/S100a11,ITGAV,LOX | NA |
| NELFB | -1.30e-01 | other | Inhibited | -2.00e+00 | 1.0e-02 | CDKN1A,GADD45A,GADD45B,MAD2L1 | NA |
| ARHGDIA | 3.60e-01 | other | Inhibited | -2.00e+00 | 3.0e-02 | ESR1,SCNN1A,SCNN1B,SCNN1G | NA |
| quetiapine | NA | chemical drug | Inhibited | -2.00e+00 | 3.0e-02 | GRIA3,GRIN1,GRIN2C,NR4A3 | NA |
| SFRP4 | 4.00e-02 | transmembrane receptor | Inhibited | -2.00e+00 | 1.1e-01 | AXIN2,CCND1,GREM1,IL18,INHA | NA |
| coenzyme Q10 | NA | chemical drug | Inhibited | -2.00e+00 | 1.1e-01 | AGER,GRIN1,PLCB3,SCARB1 | NA |
| DL-fructose | NA | chemical - endogenous mammalian | Inhibited | -2.00e+00 | 1.3e-01 | IRAK4,NLRP3,SLC2A5,SREBF1 | NA |
| SIRT2 | 8.00e-02 | transcription regulator | Inhibited | -2.00e+00 | 1.7e-01 | CXCL10,FDFT1,LSS,Oasl2 | NA |
| TRIB1 | 9.40e-01 | kinase | Inhibited | -2.00e+00 | 1.0e+00 | PRDM16,Scd2,SMARCD2,SOCS2 | NA |
| ERBB4 | 2.20e-01 | kinase | Inhibited | -2.03e+00 | 8.0e-02 | CCND1,CDKN1A,DUSP1,EFNB2,FGF7,GADD45A,GJA1,JUN,MAP2K3,THBS1,TIMP3,TNC | NA |
| UBR5 | NA | enzyme | Inhibited | -2.04e+00 | 0.0e+00 | ATMIN,CCND1,CDKN1A,CXCL10,CXCR3,GREB1,IFIH1,IL18,IRF1,IRF7,JAK2,OAS2,OLR1,STAT1,STAT2 | 507 (11) |
| vitamin E | NA | chemical drug | Inhibited | -2.05e+00 | 1.0e-02 | Casp12,CAV1,CDKN1A,COL2A1,NFIL3,NOS1,PCNA,PLAT,PRMT1,SCARB1,SERPINE1,UCP2 | NA |
| AGTR1 | 5.00e-01 | G-protein coupled receptor | Inhibited | -2.06e+00 | 1.0e-02 | AGT,CCL5,CCND1,DUSP1,JUN,OLR1,REN,SCNN1A,SCNN1B,SERPINE1 | 700 (22) |
| PNPLA2 | 6.00e-01 | enzyme | Inhibited | -2.06e+00 | 5.0e-02 | HSPA5,ICAM1,ITGAX,LEP,PLIN3,PNPLA2,SLC16A1,SREBF1,TGFB2,TRIM63,UCP2,UCP3 | NA |
| U0126 | NA | chemical drug | Inhibited | -2.08e+00 | 0.0e+00 | Acan,ACKR3,ADAMTS4,AGT,ALPK3,ANGPTL4,APLNR,AQP3,ATF4,AXIN2,BAD,BCL2L11,BHLHE40,CA9,CAV1,CCL5,CCND1,CCNE1,CD200,CDC42EP3,CDK18,CDKN1A,CDKN1C,CFTR,CHGB,CLDN4,COL2A1,CRY2,CXCL10,CXCL11,DEPDC5,DUSP1,DUSP5,EGR3,ELN,ESR1,ETV1,FOSL1,GADD45B,GALNT3,GJA1,GRAMD1B,HSD17B7,HSPA5,ICAM1,IER3,IFT88,IL1R2,IRF1,ITGA2B,ITGA5,ITPKC,JUN,KDSR,KIFC3,LAMB3,LEP,MRPS12,NAV3,NETO2,NFATC1,NOS1,NR4A2,NR4A3,OSMR,PAWR,PML,PPP2R3A,PRKCB,REN,SCNN1A,SERPINB2,SERPINE1,SFI1,SFTPC,SOCS1,SREBF1,STAT1,STAT3,STC2,TGFB2,TGM2,TH,THBD,THBS1,TIMP3,TLR2,TRAF1,TRIB1,TSC22D1,VASH1,YBX1,ZWINT | 760 (19) |
| miR-122-5p (miRNAs w/seed GGAGUGU) | NA | mature microRNA | Inhibited | -2.09e+00 | 5.0e-02 | ANXA11,CLDN18,FOXJ3,NFATC1,NUMBL,OSMR,PALM,SLC7A11,TRIB1,TRPV6 | NA |
| STAT1 | -1.44e+00 | transcription regulator | Inhibited | -2.11e+00 | 0.0e+00 | ACE,AGT,ALPK1,APOC2,BAD,BCL2L11,CCL5,CCND1,CCNE1,CCRL2,CD86,CDKN1A,CEACAM1,CLIC5,CX3CL1,CXCL10,CXCL11,CXCR3,EPSTI1,FGF7,GBP1,GBP4,GBP5,GREB1,GRIN1,HAPLN3,ICAM1,IFI16,IFI35,IFI44,IFI44L,Ifi47,IFIH1,Igtp,IL15RA,IL18,IL1R2,IL33,IRF1,IRF7,IRF9,Irgm1,ITGA2,ITGA5,ITGAX,JAK2,JUN,KLF4,Klrk1,MX1,NR1H3,OAS2,Oasl2,PARP9,PDGFB,PDGFC,PLSCR1,RNF213,RTP4,SLFN13,SLFN5,SOCS1,SP110,SREBF1,STAT1,STAT2,STAT3,TGFB2,TLR3,TNC,TNFSF10,TRIM21,UCP2,USP18 | 609 (15) |
| Ifn gamma | NA | complex | Inhibited | -2.11e+00 | 0.0e+00 | AGT,CCL5,CD86,CDKN1A,CSE1L,CXCL10,CXCR3,ESR1,GBP1,ICAM1,IFI44L,IL33,JAK2,NR4A3,PML,SOCS1,STAT1,TGFB2,TLR3,TNFSF10 | 569 (13) |
| aldesleukin | NA | biologic drug | Inhibited | -2.12e+00 | 1.0e-02 | CD86,EIF5A,HLA-G,IFI35,IRF1,IRF9,JAK2,MX1,NUP62,STAT1 | NA |
| bis(4-hydroxyphenyl)sulfone | NA | chemical reagent | Inhibited | -2.13e+00 | 2.0e-02 | ANGPTL4,ESR1,OLFML2B,PCSK6,SREBF1 | NA |
| dexmedetomidine | NA | chemical drug | Inhibited | -2.14e+00 | 1.0e-02 | CCNE1,CDKN1A,F2R,ICAM1,ITGA2,ITGA5,LAMB3,LAMC2,OSMR,TLR2,TNC | NA |
| miR-141-3p (and other miRNAs w/seed AACACUG) | NA | mature microRNA | Inhibited | -2.15e+00 | 7.0e-02 | BCL2L11,FOXJ3,GADD45A,IRF6,ITGAV,LEF1,LSR,RNF128,SATB1,TGFB2,ZFPM2 | NA |
| BAK1 | 4.10e-01 | other | Inhibited | -2.16e+00 | 0.0e+00 | BCL2L11,CCL5,CDKN1A,CXCL10,IRF7,Oas1b,TRIM6-TRIM34,TYK2 | 498 (20) |
| BCL11B | 1.80e-01 | transcription regulator | Inhibited | -2.16e+00 | 1.0e+00 | ADORA1,CDKN1A,LEF1,PLXND1,RORA | NA |
| MAPKAP1 | -1.60e-01 | other | Inhibited | -2.19e+00 | 1.0e-02 | CXCL10,IFI16,OAS2,SLFN5,SREBF1 | 526 (14) |
| SALL4 | NA | transcription regulator | Inhibited | -2.20e+00 | 0.0e+00 | ADAM10,ANGPTL4,CAV2,CCND1,CHEK2,EFNB2,FZD1,GUCY1A2,ID3,IRF7,ISG20,ITGAV,JUN,LASP1,LEF1,LRP2,LRRC4,NFATC1,PDGFC,RAD51,RAD9A,SERPINE1,STAT2,TLR3,VCL,WNT5A | NA |
| diazoxide | NA | chemical drug | Inhibited | -2.20e+00 | 2.0e-02 | ADRB3,KCNJ8,LEP,PTPRN,SLC39A7,UCP2 | NA |
| spironolactone | NA | chemical drug | Inhibited | -2.21e+00 | 3.0e-02 | ACE,ADRB3,CDKN1A,CTF1,CYP27B1,DUSP1,HHIP,ICAM1,LOX,PRDM16,REN,SCNN1A,Slco1a4,SLCO2A1,TIMP3 | NA |
| PLIN1 | 2.10e-01 | other | Inhibited | -2.21e+00 | 2.0e-02 | CIDEC,ITGAX,LEP,UCP2,UCP3 | NA |
| IRF1 | -1.00e+00 | transcription regulator | Inhibited | -2.21e+00 | 0.0e+00 | CCL5,CCND1,CDKN1A,CEACAM1,CFTR,CXCL10,CXCL11,GBP4,HELZ2,HLA-G,IFI35,IFI44,IFI44L,Ifi47,IFIH1,IL12RB1,IL18,IL33,IRF1,IRF7,IRF9,JAK2,MX1,OAS2,PCNA,PML,SOCS1,SP110,STAT1,STAT2,STAT3,TLR3,TNFSF10,TRADD,TRIM21 | 621 (18) |
| tiron | NA | chemical reagent | Inhibited | -2.22e+00 | 0.0e+00 | AGT,CDKN1A,DUSP1,HSPA5,TNC | 668 (19) |
| Betacatenin/TCF | NA | complex | Inhibited | -2.22e+00 | 1.0e-02 | CCND1,FGF9,GJA1,JUN,LEF1 | NA |
| olaparib | NA | chemical drug | Inhibited | -2.22e+00 | 4.0e-02 | CCND1,CDKN1A,CXCL10,PARP1,PARP2,RAD51 | NA |
| histone deacetylase | NA | complex | Inhibited | -2.22e+00 | 1.3e-01 | AFMID,CCND1,LAT,PLAT,THBS1,TNFRSF10A | NA |
| ACOX1 | -2.60e-01 | enzyme | Inhibited | -2.23e+00 | 4.0e-02 | ADAMTS1,CDKN1A,CPOX,CSTB,Cyp3a25 (includes others),GADD45A,GSDMC,HDAC1,HSPA5,LY6D,NR1H3,PAH,PEX11A,PLSCR1,RBM3,SLC16A1,TNFRSF10A,UCP2,UGCG | NA |
| TCF | NA | group | Inhibited | -2.23e+00 | 0.0e+00 | ADGRG2,CCND1,CEACAM1,DIO2,FGF9,GJA1,ID3,INHBB,LEF1,LGR5,PCSK6,SERPINE1,TK1,TSC22D1,TSPAN8,UGCG | 602 (13) |
| ETV6-NTRK3 | NA | fusion gene/product | Inhibited | -2.24e+00 | 0.0e+00 | Igtp,IRF7,IRF9,Oasl2,STAT1 | 170 (7) |
| STRA8 | NA | other | Inhibited | -2.24e+00 | 1.9e-01 | ATP2B2,MLH3,MSH5,PRDM9,TEX15 | NA |
| monobutyl phthalate | NA | chemical toxicant | Inhibited | -2.24e+00 | 2.2e-01 | HERC4,PPP1R10,RBM47,TRA2A,TWF2 | NA |
| RBL1 | -6.10e-01 | transcription regulator | Inhibited | -2.25e+00 | 0.0e+00 | BCL2L11,CCND1,CCNE1,CDC25A,CDKN1A,E2F4,MCM3,MYBL2,MYCN,PCNA,PLK1,RBL2,RRM2,SKP2,THBS1 | 657 (20) |
| IFNA4 | NA | cytokine | Inhibited | -2.26e+00 | 0.0e+00 | CCRL2,CD86,CLIC4,CXCL10,CXCL11,GBP5,H2-T24,IFIH1,Irgm1,LILRB4,MX1,PIK3AP1,PMEPA1,USP18 | 579 (17) |
| CBX5 | -3.40e-01 | transcription regulator | Inhibited | -2.27e+00 | 0.0e+00 | ASCL2,AXIN2,CDC25A,CDH17,CDKN1A,CEACAM1,GCHFR,HOXB6,KRT80,LAMB3,LEF1,MAP1LC3A,MUC13,OLR1,RNF39,RORA,SERP2,SLC7A7,SNTB1,TCEAL1,TLE4,TSPAN8 | NA |
| IFNA2 | NA | cytokine | Inhibited | -2.27e+00 | 0.0e+00 | CAV1,CCL5,CD86,CDKN1A,CEACAM1,CISH,CXCL10,CXCL11,CXCR3,GBP1,GBP4,GEM,HMGCS1,IFI16,IFI35,IFI44,IFI44L,IFIH1,IL10RB,IRF1,IRF7,IRF9,ISG20,KCNJ1,LILRB4,MX1,NPTX2,NT5E,OAS2,PARP9,PLAT,PLSCR1,PML,RASSF1,RBL2,REC8,SDC1,SOCS1,SOCS2,SP110,STAT1,TGM2,TLR3,TNFSF10,TRIM21,USP18,VEGFC | 600 (18) |
| N-[N-(3,5-difluorophenacetyl-L-Ala)]-S-phenylglycine t-butyl ester | NA | chemical - protease inhibitor | Inhibited | -2.27e+00 | 3.0e-02 | ACKR3,CCL5,CCNE1,CHAC1,COL2A1,GADD45B,HLA-G,ICAM1,IER3,ITGA5,LOX,PDGFB,POFUT1,SERPINE1,SKIL,SKP2 | NA |
| MUC1 | NA | other | Inhibited | -2.27e+00 | 2.8e-01 | BAD,CCND1,CD83,CD86,HSPA5,IFIH1,RASSF1,STAT1,TXNRD1,UPP1 | NA |
| IFN Beta | NA | group | Inhibited | -2.30e+00 | 0.0e+00 | AFMID,CAV1,CCL5,CD83,CD86,CDC25A,CDKN1A,CXCL10,CXCL11,DHX58,DUSP1,HLA-G,ICAM1,IFI16,IFI35,IFI44,IFIH1,IL15RA,IL20,IRF1,IRF7,IRF9,ISG20,LILRB4,MSH2,MX1,Oas1b,OAS2,OLR1,PPP1R3B,RAB30,SERPINE1,SLC7A11,SOCS1,STAT1,STAT2,THBS1,TLR3,TLR5,TNFSF10,TNFSF18,TXNRD1,USP18,VDR | 594 (16) |
| trans-hydroxytamoxifen | NA | chemical drug | Inhibited | -2.30e+00 | 0.0e+00 | ACTN4,ASCC3,BRPF1,CAV1,DUSP1,EGR3,EPOR,FGF9,FMO5,GPRC5A,GREB1,IER3,INHBB,INPP5J,IRF6,ITGA2,L1CAM,LOX,LOXL3,MPPED2,NDRG1,RAB30,SMPD1,SRD5A1,STAT1,STXBP3,TGFB2,VEGFC | 662 (12) |
| SENP3 | 7.00e-02 | peptidase | Inhibited | -2.31e+00 | 0.0e+00 | CD86,CXCL10,H2-T24,IFI44,IRF7,ISG20,OAS2,Oasl2,PML,SP110,STAT1,TNFSF10 | 524 (14) |
| IFN type 1 | NA | group | Inhibited | -2.32e+00 | 0.0e+00 | CCL5,CX3CL1,CXCL10,DHX58,IFI16,IFIH1,IRF1,PML,STAT1,STAT2,TNFSF10 | 537 (16) |
| calphostin C | NA | chemical drug | Inhibited | -2.32e+00 | 3.0e-02 | AGT,AXIN2,CCND1,CDC25A,CDKN1A,DUSP1,HSPA5,ICAM1,NQO1,PDIA4,SCARB1 | NA |
| PHF12 | 1.70e-01 | transcription regulator | Inhibited | -2.33e+00 | 0.0e+00 | BRIX1,EXOSC6,GTPBP10,GTPBP4,NMD3,RRS1,SURF6,TSR1,WDR12 | NA |
| 1,1-diarylethylene-diammonium derivative | NA | chemical reagent | Inhibited | -2.36e+00 | 0.0e+00 | AURKA,CDKN1A,HELZ2,ICAM1,IFI35,IFI44,IFIH1,IRF7,IRF9,ISG20,OAS2,PARP14,PARP9,PDE4B,PLK1,SP110,ST3GAL5,STAT1 | NA |
| BAX | -1.10e-01 | transporter | Inhibited | -2.38e+00 | 1.0e-02 | BCL2L11,BIRC2,CCL5,CDKN1A,CXCL10,ETV1,IRF7,Oas1b,TGM2,TRIM6-TRIM34,TYK2 | 594 (22) |
| CD274 | -4.00e-02 | enzyme | Inhibited | -2.38e+00 | 4.0e-02 | ATF4,ATG7,ATM,CCL5,CD86,CXCR3,ICAM1,MX1,OAS2,STAT3,TGFB2,TNFSF10 | NA |
| SCAP | -2.70e-01 | other | Inhibited | -2.38e+00 | 9.0e-02 | ASNS,ELOVL5,FADS1,FDFT1,GPAM,HES6,HMGCS1,LSS,MTHFD2,OLR1,Scd2,SREBF1 | NA |
| CHEK1 | NA | kinase | Inhibited | -2.38e+00 | 1.0e-02 | BCL2L11,CDC25A,CDKN1A,MAD2L1,PCNA,RRM2 | 484 (16) |
| MAP2K5 | -6.70e-01 | kinase | Inhibited | -2.39e+00 | 0.0e+00 | BCAR1,CCND1,FDFT1,HMGCS1,HSD17B7,JUN,LSS,NR4A3,SREBF1,TH,THBS1 | 490 (13) |
| Interferon alpha | NA | group | Inhibited | -2.39e+00 | 0.0e+00 | ADAMTS1,ANKRD6,APOL2,AQP3,ASNS,BCL3,BHLHA15,CABP7,CAV1,CCL5,CCND1,CD83,CD86,CDC25A,CDKN1A,CEACAM1,CISH,CSF2RB,CXCL10,CXCL11,CXCR3,DHX58,E2F4,EIF1,EPSTI1,EZH2,F2R,GBP1,GBP5,GNA15,HELZ2,HLA-G,HMMR,HSPA1A/HSPA1B,ICAM1,IFI16,IFI35,IFI44,IFI44L,Ifi47,IFIH1,IL15RA,IRF1,IRF7,IRF9,ISG20,ITGA11,LILRB4,LTBP1,MARCKSL1,MCM3,MEFV,MERTK,MTHFD2,MX1,MYOF,NF2,NFIL3,NT5E,NUSAP1,Oas1b,OAS2,Oasl2,PARP14,PARP9,PLAT,PLSCR1,PML,PRC1,PTBP1,RGS10,RNF213,RTP4,SLC5A1,SLC6A4,SLFN13,SLFN5,SOCS1,SOCS2,SP110,STAP2,STAT1,STAT2,STAT3,STC2,TGM1,TGM2,TLR2,TLR3,TNFSF10,TNFSF18,Tpm4,TRIM21,TSC22D1,TSPAN8,TUBB6,USP18,VCAN | 548 (15) |
| mir-30 | NA | microRNA | Inhibited | -2.40e+00 | 4.0e-02 | CDKN1A,GADD45A,ITGA2,MYBL2,NT5E,SERPINE1,SKP2,TXNDC5,UBE2I | NA |
| mir-181 | NA | microRNA | Inhibited | -2.40e+00 | 4.8e-01 | BCL2L11,CDKN1A,EZH2,ICAM1,PRKCD,TGM2,TIMP3 | NA |
| CSHL1 | NA | growth factor | Inhibited | -2.41e+00 | 4.5e-01 | CISH,GHRL,IRF1,SERPINH1,SOCS2,SRD5A1 | NA |
| NOSTRIN | 2.00e-01 | transcription regulator | Inhibited | -2.42e+00 | 5.0e-02 | ACE,CAV1,CCL5,COL18A1,ITGA5,THBS1 | NA |
| 2,3-bis(4-hydroxyphenyl)-propionitrile | NA | chemical reagent | Inhibited | -2.42e+00 | 1.0e-02 | BAD,CCND1,Cxcl3,FDFT1,H6PD,HDAC4,HDAC5,HMGCS1,INPP4B,NQO1,PCNA | 524 (11) |
| tripterine | NA | chemical - endogenous non-mammalian | Inhibited | -2.42e+00 | 7.0e-02 | DNAJB1,HSPA1A/HSPA1B,HSPH1,NF2,OLR1,TRIM63 | NA |
| LY294002 | NA | chemical drug | Inhibited | -2.42e+00 | 0.0e+00 | ACKR3,ADAMTS1,AGL,ANPEP,AQP3,ATF4,ATM,ATP2B2,AURKA,BAD,BCL2L11,BHLHE40,CA9,CCL5,CCND1,CCNE1,CD83,CD86,CDKN1A,CLCN3,CLDN4,CNR1,CRYAA/LOC102724652,CUL4A,CXCL10,DLG2,DUSP1,EFNB2,EGR2,EGR3,EPAS1,ESR1,F2R,FDFT1,FGF7,FOSL1,GBP1,GEM,GJA1,GRB10,HK2,HMGCS1,HSPA5,ICAM1,IDE,IER3,IL19,IL1R2,IL33,INHA,INHBB,INPP4B,IRF1,ISG20,ITGA2B,ITGAV,JUN,JUP,L3MBTL1,LAMB3,LAMC2,LEP,MAP2,MPDZ,MTHFD2,NDRG1,NPHS2,NQO1,NR4A2,NR4A3,OPRD1,PCNA,PDE4B,PLPP3,PTPN1,PTPRU,RBL2,REN,SATB1,SCARB1,SERPINE1,SMC2,SOCS2,SREBF1,THBD,THBS1,TLR2,UBE2C,VCAN,VEGFC,WNT5A,ZNF184,ZWINT | 761 (21) |
| IRF5 | 8.00e-02 | transcription regulator | Inhibited | -2.42e+00 | 0.0e+00 | CCL5,CDKN1A,CXCL10,CXCL11,DHX58,IFI44,IFIH1,IRF7,ISG20,OAS2,Oasl2,PLSCR1,SP110,STAT1,STAT2,TMPO,TNFSF10,USP8 | 481 (17) |
| IL2RG | -3.10e-01 | transmembrane receptor | Inhibited | -2.43e+00 | 3.1e-01 | CRY1,CXCL10,ILVBL,IRF7,JUN,STAT1,TLR3 | NA |
| SRSF2 | 3.70e-01 | transcription regulator | Inhibited | -2.45e+00 | 0.0e+00 | ATF4,AURKA,CCND1,HNRNPL,HSD3B7,NR1H4,PLK1,PTBP1,RRM2,SREBF1,TNFRSF10A | 474 (11) |
| ATP2B2 | -7.00e-01 | transporter | Inhibited | -2.45e+00 | 1.8e-01 | Casp12,CDKN1A,GADD45A,HSPA5,IL12RB1,TYK2 | NA |
| IFNA1/IFNA13 | NA | cytokine | Inhibited | -2.46e+00 | 0.0e+00 | CD83,CD86,CXCL10,CXCL11,DHX58,GEM,IFIH1,IRF1,IRF7,MX1,OAS2,PLSCR1,SOCS1,STAT1,STAT2,TLR3,UBE2D1 | 597 (18) |
| COPS5 | -1.20e-01 | transcription regulator | Inhibited | -2.47e+00 | 0.0e+00 | AK1,AMD1,BLCAP,CCNE1,CCNF,CDKN1A,CSE1L,DDX39A,DSCC1,E2F4,F2R,FGF13,HMGA1,HMMR,HNRNPD,INHBB,MAD2L1,MPG,MRAS,MSH2,MYBL2,NCL,PCNA,PDE4B,PHLDA3,POLD1,SLC3A2,SLC7A5,SMC2,SMC6,SNAPC4,STAT3,TBRG4,TFRC,TK1,TMPO,UPP1,WRN | 713 (24) |
| RBL2 | -6.90e-01 | other | Inhibited | -2.47e+00 | 0.0e+00 | AURKA,BCL2L11,CCND1,CCNE1,CCNF,CDC25A,CDKN1A,E2F4,MAP2K3,MAP3K14,MYBL2,MYCN,PCNA,PLK1,POLD1,PPM1G,PRIM2,RBL2,RRM2,TMEM11 | 548 (17) |
| Immunoglobulin | NA | complex | Inhibited | -2.51e+00 | 0.0e+00 | ACBD5,ADAM10,AGER,AGT,ANPEP,APLNR,APOL2,ATG7,ATM,ATP6V1E2,BAD,BCAT1,BCL2L11,BCL3,BIN1,BMP7,CCL5,CCND1,CCNE1,CD300LF,CD83,CD86,CDKN1C,CHEK2,CISH,CLDN15,CLEC7A,CRISPLD2,CSF2RB,CUL4A,CXCL10,CXCL11,CXCR3,CYP27B1,DSP,DUSP1,EGR2,EGR3,ELN,ENO3,ESR1,EXT1,EZH2,FAM107A,GBP5,GMPR,GPR83,H2-T24,HELZ2,HK2,HLA-G,HMGA1,ICAM1,IER3,IFI16,IL10RB,IL15RA,IL18,IL1R2,IL33,IRF1,IRF7,ISG20,ITGAX,JAK2,JUP,KLF4,LILRB4,LOX,MAD2L1,MAFF,MAP3K14,MEFV,MERTK,MICAL2,MMP15,MMP19,MOV10,MSS51,MTHFD1,MTHFD2,MX1,NFATC1,NFIL3,NLRP3,NOS1,NT5E,Oas1b,OAS2,OLR1,OSBPL3,PARP14,PDE3B,PENK,PIK3R5,PLIN4,PLSCR1,PNPLA2,PPAT,RAD51,RNF128,RPIA,RRM2,SATB1,Scd2,SDC1,SEMA4B,SLC25A43,SLC3A2,SLC7A11,SLC7A5,SLFN13,SOCS1,STAT1,STAT2,STAT3,TFRC,TGFBR3,THBD,TLR2,TLR3,TNFSF10,TRADD,TRAF1,TRPV1,TXNRD1,USP18,USP38,VCAN,VPS16,ZFYVE21 | 713 (20) |
| CST5 | NA | other | Inhibited | -2.53e+00 | 0.0e+00 | ABLIM1,ABT1,ACAT2,ARF6,BRIX1,CAV1,CEBPZ,DSP,DTNB,ELK3,GNL3,GPRC5A,GTPBP10,ID3,JMJD1C,KDM5B,MYO10,MYO5B,NAV3,NCL,NF2,NIFK,NIP7,NOL9,NT5DC3,NT5E,PDLIM5,PPAN,PRKACB,RBM3,RBM47,RNPC3,RRP1,RRS1,SH3TC2,SLC7A11,STN1,SURF6,VCAN,VPS36 | NA |
| MSC | 2.80e-01 | transcription regulator | Inhibited | -2.53e+00 | 4.0e-02 | BMP7,EPSTI1,FUT7,IFI44,IFI44L,IRF7,LGALS12,PSD3,SYNE2,TRIB1 | NA |
| TFAP2A | 4.50e-01 | transcription regulator | Inhibited | -2.54e+00 | 2.0e-02 | ADRA1D,BLCAP,CCND1,CDKN1A,CX3CL1,ESR1,EZH2,F2R,GEM,IL20,KLF4,NOS1,POR,RAD51,RBL2,RRM2,SERPINE1,SMPD1,STX7 | NA |
| stallimycin | NA | biologic drug | Inhibited | -2.59e+00 | 0.0e+00 | BMP7,CXCL10,IFI16,IFI44,IFIH1,IL20,IRF1,IRF7,MX1,PML,SP110,STAT1,TNFSF10 | 568 (15) |
| FMR1 | -1.40e-01 | translation regulator | Inhibited | -2.62e+00 | 1.0e+00 | ATP2B2,ATP6V1E1,DLG2,DLGAP2,EGR3,GRIN1,MRPL34,MTG2,PLAT,RPL9,RPS18,SLC38A1,STX11,SV2B,SYT5,VGF | NA |
| IFNL4 | NA | cytokine | Inhibited | -2.64e+00 | 0.0e+00 | CXCL10,CXCL11,DHX58,IFIH1,MX1,OAS2,STAT1 | 221 (9) |
| RNY3 | NA | other | Inhibited | -2.65e+00 | 1.0e-02 | CXCL10,EPSTI1,IFI44,IFI44L,MX1,OAS2,RTP4 | NA |
| aprepitant | NA | chemical drug | Inhibited | -2.65e+00 | 4.0e-02 | FLRT3,L1CAM,LAMB3,SPON2,TIMP3,TNC,VDR | NA |
| IFNB1 | 3.90e-01 | cytokine | Inhibited | -2.70e+00 | 0.0e+00 | AGL,APOL2,BHLHE40,CCL5,CD83,CD86,CDKN1A,CX3CL1,CXCL10,CXCL11,DHX58,DLL1,F2R,GAS1,GBP1,GBP4,GBP5,GPC4,HMGCS1,IFI16,Ifi47,IFIH1,Igtp,IL18,IRAK4,IRF1,IRF7,IRF9,Irgm1,ISG20,ITGAV,ITGAX,MX1,NFATC1,NOCT,Oas1b,OAS2,Oasl2,PARP14,PARP9,PKP2,PML,RAD51,RASSF1,SERPINB2,SLFN13,SOCS1,STAT1,STAT2,THBS1,TLR3,TNFRSF10A,TNFSF10,TRIM21,TRIM6-TRIM34,USP18,VCL,VDR | 552 (15) |
| SKIC2 | NA | enzyme | Inhibited | -2.71e+00 | 0.0e+00 | ASNS,BCAT1,BHLHE40,GLRX,HK2,IL33,MTHFD2,P4HA1,SLC7A11,SLC7A5,TFRC | NA |
| mir-183 | NA | microRNA | Inhibited | -2.72e+00 | 1.0e-02 | IFI44L,JUP,KLF4,OAS2,RTP4,SLC30A1,SLC39A7,SLFN5,SP110,STAT1,TRIM27 | 197 (10) |
| bromodeoxyuridine | NA | chemical drug | Inhibited | -2.75e+00 | 0.0e+00 | BMP7,CXCL10,IFI16,IFI44,IFIH1,IL20,IRF1,IRF7,MX1,PML,SERPINE1,SP110,STAT1,TNFSF10 | 624 (21) |
| IRF3 | -6.70e-01 | transcription regulator | Inhibited | -2.85e+00 | 0.0e+00 | BIRC2,CCL5,CCRL2,CD86,CLIC4,CX3CL1,CXCL10,Cxcl3,DHX58,GBP1,GBP5,HELZ2,ICAM1,IFI16,IFI44,IFI44L,Ifi47,IFIH1,Igtp,IL20,IL33,IRF1,IRF7,Irgm1,ISG20,Klrk1,OAS2,Oasl2,PAH,PARP14,PML,PPP2R3A,SAP30,STAT1,STAT2,TIMP3,TLR3,TMPO,TNFSF10,USP18,USP8 | 266 (13) |
| PD98059 | NA | chemical - kinase inhibitor | Inhibited | -2.97e+00 | 0.0e+00 | ACAT2,ACE,AGT,AMD1,ANPEP,ATF4,ATP6V1B1,BCL2L11,CAV1,CCL5,CCND1,CCNE1,CD55,CD83,CD86,CDC25A,CDKN1A,CSTF1,CXCL10,DHRS3,DIO2,DUSP1,DUSP5,E2F4,EGR2,EGR3,ELN,EPAS1,F2R,FOSL1,GADD45A,GHRL,GJA1,GNRHR,GRIN1,GRIN2C,HAS1,HSPA5,ICAM1,ID3,IER3,ITGA2,ITGA2B,ITGAV,ITGAX,JUN,LAMA5,LAT,LEP,LIPG,MAPKAPK2,MYBL2,MYCN,NOP56,NOS1,NQO1,OSMR,PAWR,PCNA,PCSK6,PDGFB,PLA1A,PLAT,PPP1R10,RAB20,REN,RRM2,RTCB,SCARB1,SCNN1A,SDC1,SERPINB2,SERPINE1,SLC3A2,SOCS2,SREBF1,STAT3,TH,THBD,THBS1,TLR2,TNFRSF10A,TRAF1,TSC22D1,TUBB2A,VAPA,VASH1,VCAN,VDR,VEGFC,ZNF143 | 756 (18) |
| MXD1 | 1.80e-01 | transcription regulator | Inhibited | -2.98e+00 | 2.6e-01 | EIF4A1,EIF4E,Gar1,ITGAX,NEDD9,NOP56,NOP58,RBL2,TNFRSF21 | NA |
| ARID2 | -3.00e-01 | transcription regulator | Inhibited | -3.00e+00 | 3.0e-02 | EFNB2,EIF6,EXT1,HAS1,HEG1,PTPRN,RAD51,THBS1,WNT5A | NA |
| RICTOR | 0.00e+00 | other | Inhibited | -3.05e+00 | 1.0e+00 | ATP4A,ATP6V1B1,ATP6V1E1,ATP6V1E2,BAD,BCL2L11,HK2,IFI16,NDUFA5,NIPAL1,OAS2,PAK1,PRKCB,RPL9,RPS18,SREBF1,TRIM21 | NA |
| Ifn | NA | group | Inhibited | -3.06e+00 | 0.0e+00 | ADAMTS1,CD83,CD86,CXCL10,CXCL11,CXCR3,DHX58,ICAM1,IFI16,IFIH1,IL15RA,IL33,IRF1,IRF7,ISG20,MX1,OAS2,PML,SERPINE1,SOCS1,STAT1,TFRC,TLR2,TLR3,TLR5,TRIM21 | 544 (16) |
| IFNL1 | NA | cytokine | Inhibited | -3.11e+00 | 0.0e+00 | CD83,CHAC1,CXCL10,CXCL11,F2R,GBP1,GBP5,IFI35,IFI44,IFI44L,IFIH1,IRF9,ISG20,MX1,OAS2,PLSCR1,PML,RTP4,SP110,STAT1,STAT2,TLR2,USP18 | 726 (18) |
| pyridostatin | NA | chemical reagent | Inhibited | -3.16e+00 | 0.0e+00 | CCL5,CCRL2,CXCL10,CXCL11,DHX58,GBP4,GMPR,HELZ2,IFI35,IFI44,IFI44L,IFIH1,IRF1,IRF7,IRF9,ISG20,MOV10,MX1,PARP14,PARP9,PLSCR1,RTP4,SLC25A28,SP110,STAT2,TRIM21,USP18 | 271 (13) |
| LEF1 | -1.27e+00 | transcription regulator | Inhibited | -3.17e+00 | 2.0e-02 | Acan,ARHGEF26,AXIN2,C3orf70,CARD11,CAV1,CCL5,Ccl6,CCND1,CD200,CD83,CDKN1A,EMILIN2,FLT3,FRMD6,GEM,GPR15,GPR83,Gprasp2,HEATR9,LEF1,LY6D,METRNL,NCOA7,NLRP3,NUMBL,PDGFB,PENK,PTPRO,RNF8,Serpinb6b,STX11,TEX15,TIAM1,TLR2,TSC22D1,ZNF467 | NA |
| ZBTB10 | 9.00e-02 | transcription regulator | Inhibited | -3.36e+00 | 0.0e+00 | BCL2L11,CCL24,CCL5,CD83,CD86,CX3CL1,CXCL10,DHX58,DTX3L,ELMOD2,ESR1,GBP4,GBP5,HLA-G,IFI16,Ifi47,IFIH1,Igtp,IL10RB,IL20,IRF1,Irgm1,ISG20,Klrk1,MAP3K14,NLRX1,NR4A3,PARP9,RTP4,SERPINE1,SLFN13,STAT2,TRIM6-TRIM34 | 627 (11) |
| Ifnar | NA | group | Inhibited | -3.41e+00 | 0.0e+00 | CCL5,CD86,CXCL10,HLA-G,IFI16,IFI35,IFIH1,IRF1,IRF7,IRF9,Irgm1,ISG20,NLRP3,OAS2,RNF213,STAT1,STAT2,TLR2,TLR3,TNFSF10,TRIM21,USP18 | 582 (16) |
| IRF7 | -7.40e-01 | transcription regulator | Inhibited | -3.49e+00 | 0.0e+00 | ATF4,CCL5,CCRL2,CXCL10,DHX58,DNAJA1,FZD1,GBP1,GBP4,GBP5,HELZ2,IFI16,IFI35,IFI44,IFI44L,Ifi47,IFIH1,Igtp,IL15RA,IL33,IRF1,IRF7,IRF9,Irgm1,ISG20,ITGAX,JAK2,MX1,OAS2,Oasl2,PARP14,PLSCR1,RTP4,SAP30,SOCS1,STAT1,STAT2,TMPO,TNFSF10,TRAF1,TRIM21,USP18,USP8 | 265 (14) |
| NONO | -2.60e-01 | transcription regulator | Inhibited | -3.54e+00 | 0.0e+00 | ATP10A,CCL5,CXCL10,CXCL11,EPSTI1,GBP1,GBP4,GBP5,GCH1,GMPR,IFI44,IFI44L,IFIH1,ISG20,MX1,OAS2,PARP14,PARP9,PDE10A,PDE1B,PDE3B,PDE4A,PDE4B,PDE4D,PLSCR1,PML,RNF213,RTP4,SLFN5,SP110,STAT1,STAT2,TLR3,TNFSF10,TNFSF18,USP18 | 312 (7) |
| CHROMR | NA | other | Inhibited | -4.78e+00 | 0.0e+00 | BCL3,CDKN1A,CXCL10,CXCL11,DHX58,DTX3L,DUSP5,EPSTI1,EXT1,GBP1,GBP4,GBP5,GCH1,GEM,IFI16,IFI35,IFI44,IFI44L,IFIH1,IRF1,JAK2,MAFF,MOV10,MX1,OAS2,PABPC4,PIM3,PLSCR1,PML,RTP4,SERPINE1,SLC25A28,SP110,STAT1,STAT2,THBD,TLR3,TNFSF10,USP18,VEGFC | NA |
| Histone H2b | NA | group | NA | NA | 0.0e+00 | HTATIP2,Ifi47,IRF1,IRF2BPL,PPP1R3B,SLC7A11,TNFSF10 | NA |
| Histone h4 | NA | group | NA | NA | 0.0e+00 | AFMID,AGT,BTG3,CCL5,CCND1,CCNE1,CDC25A,CDKN1A,CXCL10,ESR1,GADD45B,GAS1,ICAM1,IRF1,KDM5B,LEF1,MAD1L1,MAD2L1,MCM3,MCM4,MSH2,MSH5,Mt1,NEURL1,PCNA,RRM2,SHANK2,SREBF1,STAT3,TBX4,TBX6,TNFSF10,TRPV6 | 664 (20) |
| ADRA1D | 8.90e-01 | G-protein coupled receptor | NA | NA | 0.0e+00 | CCNE1,CSRP2,DUSP1,EGR2,FGF7,JUN,LOX,NR4A2,PAK1,PCNA,POLA1,PRIM2,Scd2,STAT3,TMPO | 670 (18) |
| TRRAP | -5.20e-01 | transcription regulator | NA | NA | 0.0e+00 | BCL2L11,CDKN1A,MAD1L1,MAD2L1,MCM3,MCM4,NCL,PCNA | 591 (16) |
| RNASEH2A | 3.00e-02 | enzyme | NA | NA | 0.0e+00 | ACKR3,CXCL10,IFI16,IFI35,IFI44,IFIH1,IRF1,IRF7,IRF9,ISG20,PARP9,TLR2,TLR3,TRIM21,USP18 | NA |
| ADRA1A | -7.90e-01 | G-protein coupled receptor | NA | NA | 0.0e+00 | CCNE1,CSRP2,DUSP1,EGR2,FGF7,JUN,LOX,NR4A2,PAK1,PCNA,POLA1,PRIM2,Scd2,STAT3,TMPO | 740 (24) |
| TIP60 | NA | complex | NA | NA | 0.0e+00 | CDKN1A,COL2A1,MCM3,MCM4,MYCN,PCNA | 633 (20) |
| ADRA1B | 6.70e-01 | G-protein coupled receptor | NA | NA | 0.0e+00 | ADRA1D,CCND1,CDKN1A,CSRP2,DUSP1,EGR2,FGF7,JUN,LEP,LOX,NR4A2,PAK1,Scd2,TMPO | 699 (19) |
| PRKAG3 | -4.40e-01 | kinase | NA | NA | 0.0e+00 | ACKR3,AMD1,ANGPTL4,ASPH,CD55,CIDEC,CLCN3,DDIT4L,FTL,GJA1,GLRX,HIVEP2,HSPA5,JPH1,KLF4,LEP,MID1IP1,NOS1,PHLDA3,PLIN3,POLK,RASD2,RNF128,Scd2,SLC4A3,SORD,SREBF1,STK11IP,TFRC,TSPAN8 | NA |
| CDC27 | 1.20e-01 | other | NA | NA | 0.0e+00 | CCND1,PLK1,SKP2,UBE2C | 176 (8) |
| GNA15 | -8.00e-01 | enzyme | NA | NA | 0.0e+00 | ACKR3,CAV2,FGF7,FMO1,FOSL1,FXYD5,GADD45A,HSD3B7,MAFK,MAP2,MICOS10-NBL1/NBL1,Mt1,OLR1,PAWR,PLAT,PRSS35,RAPGEF4,SLC6A4,SORBS2,THBD,VCAN | 658 (13) |
| n-nitrosomethylbenzylamine | NA | chemical toxicant | NA | NA | 0.0e+00 | ACTN4,ALS2,CCND1,DUSP5,GREM1,GSTT2/GSTT2B,HMMR,IDH1,INHBB,KIFAP3,LAMB3,MAP2K3,MYO10,PCNA,RAD23B,RBBP6,RLIM,SDC1,SH2D2A,SLC30A1,TTC1,TUBB6,UBE2C,UBE3D | NA |
| PSMD14 | 2.20e-01 | peptidase | NA | NA | 0.0e+00 | BCL2L11,BCL3,CCND1 | 554 (13) |
| OLA1 | -1.30e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,CCNE1,CDKN1A | 394 (11) |
| RBCK1 | -4.70e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CXCL10,CXCL11,ESR1,GBP1,GBP4,GBP5,ICAM1,IL33,IRF1 | 672 (16) |
| DYNLL1 | -3.00e-01 | other | NA | NA | 0.0e+00 | BCL2L11,CCNE1,CDKN1A,NOS1 | 634 (13) |
| GNA14 | 3.90e-01 | enzyme | NA | NA | 0.0e+00 | ADAMTS1,ANPEP,CX3CL1,DUSP5,GADD45A,GJA4,GRB14,HK2,HSPB8,NFIL3,NR4A2,OLR1,PDLIM5,PLAT,STAT1 | 505 (7) |
| SP2 | 4.40e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A,CEACAM1,PRKCD,SERPINE1,SERPINH1 | NA |
| RRP1B | 9.70e-01 | transcription regulator | NA | NA | 0.0e+00 | AURKA,BMP7,CCND1,CCNE1,CDKN1A,GADD45A,HDAC11,MCM3,MCM4,MRAS,NCOA2,PCNA,PDGFC,PLK1,POLD1,PRKCD,RPA1,RRP1B,VDR,VEGFC | NA |
| SBDS | 3.20e-01 | other | NA | NA | 0.0e+00 | AKNA,CHAC1,CPLX1,DNAJB1,FBXO32,GADD45B,GSTT2/GSTT2B,HOXB6,HSPA5,IFI16,LGR5,MAFF,P2RX5,PTBP2,PTPRO,TERF2IP,TNC | NA |
| GNB1 | 2.70e-01 | enzyme | NA | NA | 0.0e+00 | CD83,CDKN1A,DGAT1,DUSP1,F2R,IER3,IL1R2,NR4A2,PDE4B,THBD | 535 (13) |
| RUVBL2 | 0.00e+00 | transcription regulator | NA | NA | 0.0e+00 | AXIN2,CCND1,MCM3,MCM4,PCNA | 113 (5) |
| IFNLR1 | 4.50e-01 | transmembrane receptor | NA | NA | 0.0e+00 | CCL5,CLEC4D,CXCL10,Cxcl3,IFI44,IFIH1,IRF7,ITGAV,MX1,THBS1,TLR2 | 562 (17) |
| SLC9A3 | -1.98e+00 | ion channel | NA | NA | 0.0e+00 | CCL5,CCND1,Ifi47,Igtp,Mt1,SLC5A1,STAT1,UPP1 | 515 (7) |
| black raspberry extract | NA | chemical drug | NA | NA | 0.0e+00 | ACTN4,ALS2,DUSP5,GREM1,HMMR,INHBB,KIFAP3,LAMB3,MAP2K3,MYO10,RAD23B,RBBP6,RLIM,SDC1,SH2D2A,SLC30A1,TTC1,TUBB6,UBE2C,UBE3D | NA |
| APC (complex) | NA | complex | NA | NA | 0.0e+00 | CCNE1,PLK1,SKP2,UBE2C | 356 (8) |
| LDLR | 5.00e-02 | transporter | NA | NA | 0.0e+00 | AURKA,AXIN2,CCL5,CCND1,CD55,CDKN1A,CX3CL1,DUSP1,GJA1,GJA4,GPAM,H6PD,HK2,HSPA5,ICAM1,IER3,IL12RB1,IRF7,KNL1,MERTK,MID1IP1,NR1H3,NUSAP1,PARP1,PLK1,PRC1,RAD51,SCARB1,Serpinb6b,SOCS1,SREBF1,TRIB1,UBE2C,UCP3,VCAN | 751 (20) |
| KIT | 1.00e-01 | transmembrane receptor | NA | NA | 0.0e+00 | BCL2L11,CISH,CSF2RB,CXCL10,ETV1,ICAM1,Ifi47,Igtp,IL12RB1,IL15RA,IRF1,ITGA2B,ITGAX,LILRB4,PSTPIP2,SH3BP2,SOCS1,SOCS2,STAT1,STAT3 | 762 (21) |
| halofuginone | NA | chemical drug | NA | NA | 0.0e+00 | BHLHE40,CD200,CD55,CDH17,CKB,CXCL10,ELN,F2R,GDE1,GYG1,IL33,LOX,LRAT,LTBP1,PCSK6,PLPP3,POR,PROM1,PTGFRN,Scd2,SLC13A3,STEAP3,TGM2,WNT5A | 575 (12) |
| NDUFB2 | 6.00e-02 | enzyme | NA | NA | 0.0e+00 | CCL5,CXCL10,CXCL11 | 486 (16) |
| DNAJB4 | -4.70e-01 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A,STAT1 | 563 (15) |
| CHFR | -1.80e-01 | enzyme | NA | NA | 0.0e+00 | AURKA,PARP1,PLK1 | NA |
| GIPC1 | 7.00e-02 | other | NA | NA | 0.0e+00 | PROX1,SERPINE1,TGFBR3 | NA |
| BANP | -1.27e+00 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A,STAT3,TUBGCP5 | 552 (16) |
| BLM | -7.50e-01 | enzyme | NA | NA | 0.0e+00 | CDKN1A,IFI44L,ISG20,MX1 | 351 (7) |
| EIF2A | -1.30e-01 | translation regulator | NA | NA | 0.0e+00 | ATF4,ECD,EGR2,HSPA5,ICAM1,ITGAX,JUN | 608 (16) |
| GNB2 | 2.00e-02 | enzyme | NA | NA | 0.0e+00 | CD83,CDKN1A,DGAT1,DUSP1,IER3,IL1R2,NR4A2,PDE4B,THBD | 80 (3) |
| IFNA17 | NA | cytokine | NA | NA | 0.0e+00 | CD86,CXCL10,CXCL11,IFIH1,MX1 | 190 (8) |
| NPFF | -4.50e-01 | other | NA | NA | 0.0e+00 | ACE,ADRB3,CTF1,ID3,SREBF1 | NA |
| discodermolide | NA | chemical drug | NA | NA | 0.0e+00 | BLM,CDC25A,CDKN1A,FANCG,GADD45A,PLK1,PRC1,RAD51,SMC2 | 458 (7) |
| PHF8 | -1.01e+00 | enzyme | NA | NA | 0.0e+00 | CCNE1,CDC25A,PRAM1,TGM2 | 314 (11) |
| p38 Sapk | NA | group | NA | NA | 1.0e-02 | CCND1,CD83,CD86 | NA |
| RAR-RXR | NA | complex | NA | NA | 1.0e-02 | IRF1,PRDM16,TGM2 | NA |
| CYP | NA | group | NA | NA | 1.0e-02 | CD86,CYP27B1,NQO1 | NA |
| DRD3 | NA | G-protein coupled receptor | NA | NA | 1.0e-02 | LEP,SLC9A3,TH | NA |
| ZMIZ2 | -2.10e-01 | transcription regulator | NA | NA | 1.0e-02 | AXIN2,CCND1,JUN | NA |
| YIPF6 | 1.20e-01 | other | NA | NA | 1.0e-02 | ADRB3,DIO2,PNPLA2 | 344 (7) |
| AZD1480 | NA | chemical drug | NA | NA | 1.0e-02 | SLC3A2,SLC7A5,SOX11 | NA |
| IL31RA | 3.50e-01 | transmembrane receptor | NA | NA | 1.0e-02 | CISH,SOCS1,SOCS2 | NA |
| ZBTB46 | -2.00e-01 | transcription regulator | NA | NA | 1.0e-02 | PHF7,STAT3,VEGFC | NA |
| RSC1A1 | NA | other | NA | NA | 1.0e-02 | LEP,SLC28A3,SLC5A1 | NA |
| PSAP | 2.10e-01 | other | NA | NA | 1.0e-02 | BIRC2,CCND1,ESR1 | 526 (14) |
| AGA | -1.00e-02 | enzyme | NA | NA | 1.0e-02 | CHEK2,MCM3,MCM4 | NA |
| POLB | -3.60e-01 | enzyme | NA | NA | 1.0e-02 | GSDMD,IL18,NLRP3 | NA |
| Foxp2 | NA | transcription regulator | NA | NA | 1.0e-02 | HOPX,MYCN,SFTPC | NA |
| GSK-2606414 | NA | chemical reagent | NA | NA | 1.0e-02 | ESR1,HSPA5,PDIA4 | NA |
| CLDN2 | -5.30e-01 | other | NA | NA | 1.0e-02 | CCND1,ITGA2,ITGA5 | NA |
| silicon phthalocyanine | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CCNE1,CDKN1A | 504 (16) |
| Collagen type V | NA | complex | NA | NA | 1.0e-02 | ITGA2,ITGA5,ITGAV | NA |
| CNOT7 | 3.00e-02 | transcription regulator | NA | NA | 1.0e-02 | IFI35,IFI44L,OAS2,PLSCR1,SLC14A1,SLC7A11,SP110,STAT1 | 172 (7) |
| GTF2I | -3.70e-01 | transcription regulator | NA | NA | 1.0e-02 | CCND1,CDKN1A,HSPA5,PDIA4,THBS1 | 596 (14) |
| MVP | -2.60e-01 | other | NA | NA | 1.0e-02 | CD83,CD86,ICAM1,IRF7,JUN,NFATC1 | 693 (19) |
| Cd33 | -2.80e-01 | other | NA | NA | 1.0e-02 | ACTR3B,ITGAX,LOX,TMEM163 | NA |
| THAP11 | 4.30e-01 | transcription regulator | NA | NA | 1.0e-02 | ATL3,GPC4,LCP1,LOX | NA |
| UGDH | 1.00e-02 | enzyme | NA | NA | 1.0e-02 | HAS1,LIPG,TBX6,TNC | NA |
| UC2288 | NA | chemical reagent | NA | NA | 1.0e-02 | Acan,COL2A1 | NA |
| DTYMK | -2.80e-01 | kinase | NA | NA | 1.0e-02 | CCL5,MAPKAPK2 | NA |
| SFTPB | 9.00e-01 | other | NA | NA | 1.0e-02 | SFTPB,SFTPC | NA |
| SCNN1G | 1.16e+00 | ion channel | NA | NA | 1.0e-02 | KCNJ1,SCNN1A | NA |
| miR-101-5p (miRNAs w/seed AGUUAUC) | NA | mature microRNA | NA | NA | 1.0e-02 | ATM,PRKDC | NA |
| CCNDBP1 | -1.70e-01 | other | NA | NA | 1.0e-02 | CCND1,MKX | NA |
| DCTN4 | -8.00e-02 | other | NA | NA | 1.0e-02 | CCL5,CXCL10 | NA |
| POLA2 | -4.80e-01 | enzyme | NA | NA | 1.0e-02 | ATXN1,POLA1 | NA |
| KHDRBS2 | -1.30e-01 | other | NA | NA | 1.0e-02 | CDKN1A,STAT1 | NA |
| GALR2 | 4.00e-02 | G-protein coupled receptor | NA | NA | 1.0e-02 | BAD,CDKN1A | NA |
| nitrosonifedipine | NA | chemical reagent | NA | NA | 1.0e-02 | AGT,ICAM1 | NA |
| CRTAP | NA | other | NA | NA | 1.0e-02 | CDKN1A,SERPINE1 | 128 (4) |
| ELDR | NA | other | NA | NA | 1.0e-02 | CCNE1,PCNA | 359 (7) |
| ZFYVE16 | -5.20e-01 | other | NA | NA | 1.0e-02 | CDKN1A,SERPINE1 | 642 (13) |
| hydroxyl radical | NA | chemical toxicant | NA | NA | 1.0e-02 | CAV1,KLF4 | NA |
| oxazepam | NA | chemical drug | NA | NA | 1.0e-02 | GADD45B,TSC22D1 | NA |
| sodium fluoride | NA | chemical drug | NA | NA | 1.0e-02 | ICAM1,LEP | 343 (7) |
| SGC-CBP30 | NA | chemical reagent | NA | NA | 1.0e-02 | CDCP1,GREB1 | 450 (7) |
| antarelix | NA | biologic drug | NA | NA | 1.0e-02 | GNRHR,NOS1 | NA |
| androsterone | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | APOC2,SLC45A3 | NA |
| SMC1A | -2.30e-01 | transporter | NA | NA | 1.0e-02 | ATM,EZH2,FLT3,IDH1,JAK2,KLF4,LEF1,Meis1,SOCS1,TINAGL1 | NA |
| ATF1 | 5.90e-01 | transcription regulator | NA | NA | 1.0e-02 | FOSL1,FUT7,HLA-G,JUN,PCNA,PDE3B,REN,THBS1,UCP3 | 338 (9) |
| mezerein | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | CDKN1A,IFIH1,IRF9,MX1,OAS2,TXNRD1 | NA |
| Hif | NA | complex | NA | NA | 1.0e-02 | ANGPTL4,CDKN1C,CKB,L1CAM,TH | NA |
| pituitary adenylate cyclase-activating polypeptide | NA | biologic drug | NA | NA | 1.0e-02 | AGL,ARHGAP32,AXIN2,BAMBI,CCND1,FOSL1,GCH1,MYCN,RET | NA |
| ATN1 | 4.20e-01 | transcription regulator | NA | NA | 1.0e-02 | BHLHE40,BTG3,CHGB,CNR1,ETV1,GRIN2C,IFI16,JUP,MARCKSL1,PABPC4,PDE1B,PENK,PRKACB,PRKCD,PTBP1,SATB1,SMC2,SOCS2,SOX11,TIAM1 | NA |
| antrodia camphorata polysaccharide | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | ASCC1,IL18,NLRP3 | NA |
| warburgia ugandensis dimethyl carbonate extract | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | CCND1,CCNE1,SKP2 | NA |
| vanillyl-N-nonylamide | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,GADD45A,HSPA5 | NA |
| olmesartan | NA | chemical drug | NA | NA | 1.0e-02 | ICAM1,SCARB1,UCP2 | NA |
| AMER1 | -2.20e-01 | other | NA | NA | 1.0e-02 | AXIN2,CDKN1A,LGR5 | NA |
| SAMD4A | 1.61e+00 | translation regulator | NA | NA | 1.0e-02 | PRDM16,UCP2,UCP3 | NA |
| SLC7A11-AS1 | NA | other | NA | NA | 1.0e-02 | CCND1,JUN,MAP3K5 | NA |
| SLC12A2 | -1.80e-01 | transporter | NA | NA | 1.0e-02 | SCNN1A,SCNN1B,SCNN1G | NA |
| NUCKS1 | 4.00e-01 | kinase | NA | NA | 1.0e-02 | CDKN1A,LEP,SKP2 | NA |
| TRPV6 | -1.06e+00 | ion channel | NA | NA | 1.0e-02 | S100G,TGM1,TRPV6 | NA |
| LGK-974 | NA | chemical drug | NA | NA | 1.0e-02 | AXIN2,LEF1,WNT9B | NA |
| BRL 37344 | NA | chemical reagent | NA | NA | 1.0e-02 | LEP,UCP2,UCP3 | NA |
| ORIN1001 | NA | chemical drug | NA | NA | 1.0e-02 | LIPC,NR1H3,SREBF1 | NA |
| 3’,4’,7-trihydroxyisoflavone | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | CCND1,CCNE1,ESR1 | NA |
| DHTKD1 | -1.70e-01 | enzyme | NA | NA | 1.0e-02 | ABCC8,GLP1R,RPH3AL,SYTL4 | NA |
| Fcor | NA | enzyme | NA | NA | 1.0e-02 | BCL2L11,CDKN1A,GADD45A,RBL2 | NA |
| pargyline | NA | chemical drug | NA | NA | 1.0e-02 | CDKN1A,MAP2,NOS1,TH | NA |
| clioquinol | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CDKN1A,HDAC1,JUN | NA |
| trifluoperazine | NA | chemical drug | NA | NA | 1.0e-02 | CHRM1,NOS1,PCNA,PROM1 | NA |
| KCNE3 | 3.00e-02 | ion channel | NA | NA | 1.0e-02 | BCAT1,CISH,HSD17B7,HSPA1A/HSPA1B,KCNJ2,KCNK5,KLF4,NFIL3,NR4A2,Slc25a2,SLC2A5,TMEM120B | NA |
| GDF15 | -6.90e-01 | growth factor | NA | NA | 1.0e-02 | CCND1,CDKN1A,LTBP1,PNPLA2,SERPINE1,TIMP3 | NA |
| NUP98-HOXA9 | NA | fusion gene/product | NA | NA | 1.0e-02 | HOXB6,HOXB7,Meis1,MSI2,NR4A2,SORBS2,TLE4 | NA |
| NFIB | -2.90e-01 | transcription regulator | NA | NA | 1.0e-02 | AQP5,CDK18,GFRA1,HSD17B7,LOX,NT5E,SFTPC,SLC16A14,TNFSF18 | NA |
| putrescine | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CDKN1A,JUN,OAZ1,TLR2 | NA |
| thymidine | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CCND1,CDKN1A,LGALS12,TK1 | NA |
| KLK4 | NA | peptidase | NA | NA | 1.0e-02 | CDKN1A,CUL4A,GADD45A,PCNA,RAD9A | NA |
| OVA-8 | NA | chemical reagent | NA | NA | 2.0e-02 | CISH,EIF6,GADD45B,Gar1,NOP58,POP5,UTP4,XPO1 | NA |
| E2F5 | 2.10e-01 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A,MYBL2,MYCN,PCNA,SERPINB2,SERPINE1 | NA |
| OSMI-1 | NA | chemical reagent | NA | NA | 2.0e-02 | CCND1,CDKN1A,HSPA5 | NA |
| histidinol | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | ASNS,ATF4,SLC7A5 | NA |
| NLGN1 | -2.70e-01 | enzyme | NA | NA | 2.0e-02 | CCND1,L1CAM,LAMC2 | NA |
| ATE1 | -1.60e-01 | enzyme | NA | NA | 2.0e-02 | CCND1,JUN,REC8 | NA |
| DGAT2 | -5.00e-02 | enzyme | NA | NA | 2.0e-02 | GPAM,SREBF1,UCP2 | NA |
| PCM1 | 4.00e-02 | other | NA | NA | 2.0e-02 | CDKN1A,MCM3,PCNA | NA |
| Collagen type III | NA | complex | NA | NA | 2.0e-02 | ITGA2,ITGA5,ITGAV | NA |
| GNE | -5.60e-01 | kinase | NA | NA | 2.0e-02 | ASNS,CHAC1,ST3GAL5 | NA |
| CCNA2 | 4.90e-01 | other | NA | NA | 2.0e-02 | CDKN1A,MYBL2,PCNA | NA |
| PDE3A | 4.80e-01 | enzyme | NA | NA | 2.0e-02 | CCND1,CDKN1A,DUSP1 | NA |
| GATAD2B | 1.20e-01 | transcription regulator | NA | NA | 2.0e-02 | EZH2,RAD51,RRM2 | NA |
| STEAP4 | -9.00e-02 | enzyme | NA | NA | 2.0e-02 | ATF4,LEP,TFEB | NA |
| YWHAB | -3.30e-01 | other | NA | NA | 2.0e-02 | CCND1,DUSP1,SCNN1A | NA |
| RAPGEF4 | 9.60e-01 | other | NA | NA | 2.0e-02 | CDKN1A,NFATC1,THBS1 | NA |
| KLKB1 | -3.40e-01 | peptidase | NA | NA | 2.0e-02 | BDKRB2,ICAM1,KLF4 | NA |
| CTH | NA | enzyme | NA | NA | 2.0e-02 | ASNS,CDKN1A,HSPA5 | NA |
| A939572 | NA | chemical reagent | NA | NA | 2.0e-02 | ATF4,LRAT,PNPLA2 | NA |
| dacarbazine | NA | chemical drug | NA | NA | 2.0e-02 | CCL5,CDKN1A,CXCL10 | NA |
| diquat | NA | chemical toxicant | NA | NA | 2.0e-02 | Mt1,NQO1,TXNRD1 | NA |
| retroinverso ERG inhibitory peptide 2 | NA | chemical reagent | NA | NA | 2.0e-02 | ADAMTS1,NDRG1,PLAT | NA |
| retroinverso ERG inhibitory peptide 1 | NA | chemical reagent | NA | NA | 2.0e-02 | ADAMTS1,NDRG1,PLAT | NA |
| HI-TOPK32 | NA | chemical reagent | NA | NA | 2.0e-02 | JUN,SLC45A3,SPDEF | NA |
| cyclosporin | NA | biologic drug | NA | NA | 2.0e-02 | CCND1,ICAM1,IL19 | NA |
| mercury | NA | chemical toxicant | NA | NA | 2.0e-02 | ESR1,Mt1,PLAT | NA |
| TAF4B | 3.20e-01 | transcription regulator | NA | NA | 2.0e-02 | IER3,INHA,INHBB,IRF1,JUN,RET | NA |
| BCO1 | 2.60e-01 | enzyme | NA | NA | 2.0e-02 | HTATIP2,NR1D1,SCARB1,SPON2 | NA |
| double-stranded DNA | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | CCL5,CXCL10,ICAM1,IRF7 | NA |
| ANG | 1.20e-01 | enzyme | NA | NA | 2.0e-02 | CCL5,CDKN1A,CXCL10,NQO1 | NA |
| FZR1 | 1.18e+00 | kinase | NA | NA | 2.0e-02 | CCND1,CCNE1,SKP2,TK1 | NA |
| PTGER1 | 0.00e+00 | G-protein coupled receptor | NA | NA | 2.0e-02 | ANGPTL4,EGR2,ICAM1,VEGFC | NA |
| S-equol | NA | chemical drug | NA | NA | 2.0e-02 | CD86,NQO1,PLAT,SERPINE1 | NA |
| BSCL2 | 3.30e-01 | other | NA | NA | 2.0e-02 | ADRB3,CCND1,CIDEC,CLEC10A,GREM1,HMGA1,IER3,IL33,LEP,LGALS12,PNPLA2 | NA |
| GY1-22 | NA | chemical reagent | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| phosphatidylethanolamine | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | STAT1,STAT2 | NA |
| minoxidil | NA | chemical drug | NA | NA | 2.0e-02 | AXIN2,LEF1 | NA |
| L-ornithine | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | CDKN1A,PNPLA2 | NA |
| DPTIP | NA | chemical reagent | NA | NA | 2.0e-02 | CX3CL1,CXCL10 | NA |
| hexa-D-arginine | NA | biologic drug | NA | NA | 2.0e-02 | GJA1,PTGFR | NA |
| ZNF219 | 3.90e-01 | transcription regulator | NA | NA | 2.0e-02 | COL11A2,COL2A1 | NA |
| BBS1 | -2.60e-01 | other | NA | NA | 2.0e-02 | ADRA1D,TH | NA |
| RHOBTB2 | -4.40e-01 | enzyme | NA | NA | 2.0e-02 | CDKN1A,MSI2 | NA |
| LRRC8E | -5.70e-01 | ion channel | NA | NA | 2.0e-02 | CCL5,CXCL10 | NA |
| Snhg5 | NA | other | NA | NA | 2.0e-02 | EPAS1,KLF4 | NA |
| ZNF451 | 2.60e-01 | enzyme | NA | NA | 2.0e-02 | CDKN1A,SERPINE1 | NA |
| NDUFAF3 | -2.10e-01 | other | NA | NA | 2.0e-02 | CCND1,ESR1 | NA |
| potassium channel | NA | group | NA | NA | 2.0e-02 | JUN,SCNN1A | NA |
| KLHL2 | -7.50e-01 | other | NA | NA | 2.0e-02 | CCND1,JUN | NA |
| ECD | -6.70e-01 | transcription regulator | NA | NA | 2.0e-02 | ATF4,HSPA5 | NA |
| bis(4-hydroxycinnamoyl)methane | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | TLR2,TLR3 | NA |
| GW 9508 | NA | chemical reagent | NA | NA | 2.0e-02 | CXCL10,NFATC1 | NA |
| defibrotide | NA | biologic drug | NA | NA | 2.0e-02 | PLAT,SERPINE1 | NA |
| MCC | 2.50e-01 | other | NA | NA | 2.0e-02 | PARP1,RAD51 | NA |
| RRAD | 1.90e-01 | enzyme | NA | NA | 2.0e-02 | ATP2A2,CCND1 | NA |
| EMP2 | 6.20e-01 | other | NA | NA | 2.0e-02 | CAV1,ITGA5 | NA |
| GAPLINC | NA | other | NA | NA | 2.0e-02 | CXCL10,TNFSF10 | NA |
| U2AF2 | 2.20e-01 | other | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| mir-675 | NA | microRNA | NA | NA | 2.0e-02 | COL2A1,KHDC1L | NA |
| MAPK15 | 5.50e-01 | kinase | NA | NA | 2.0e-02 | JUN,PCNA | NA |
| KCNQ1 | 2.00e-01 | ion channel | NA | NA | 2.0e-02 | CDKN1C,SCNN1A | NA |
| CLCN1 | 1.10e-01 | ion channel | NA | NA | 2.0e-02 | HDAC4,HDAC5 | NA |
| COL7A1 | 4.40e-01 | other | NA | NA | 2.0e-02 | THBS1,WNT5A | NA |
| ASPH | -6.40e-01 | enzyme | NA | NA | 2.0e-02 | ASPH,CCNE1 | NA |
| EIF2B1 | 4.30e-01 | translation regulator | NA | NA | 2.0e-02 | ATF4,CCND1 | NA |
| FTMT | NA | enzyme | NA | NA | 2.0e-02 | FTL,TFRC | NA |
| SLC2A5 | -8.60e-01 | transporter | NA | NA | 2.0e-02 | SLC2A5,SLC9A3 | NA |
| STRAP | 7.00e-01 | other | NA | NA | 2.0e-02 | JUN,SERPINE1 | NA |
| DDOST | 2.10e-01 | enzyme | NA | NA | 2.0e-02 | AGER,PROM1 | NA |
| DLST | 1.20e-01 | enzyme | NA | NA | 2.0e-02 | JUN,PRKDC | NA |
| PGD | NA | enzyme | NA | NA | 2.0e-02 | SLC3A2,TFRC | NA |
| SYF2 | 7.30e-01 | other | NA | NA | 2.0e-02 | CDKN1A,POLA1 | NA |
| PDZD2 | -4.30e-01 | other | NA | NA | 2.0e-02 | BAD,CDKN1A | NA |
| CUX2 | 0.00e+00 | transcription regulator | NA | NA | 2.0e-02 | DLL1,KDM5B | NA |
| GOPC | NA | transporter | NA | NA | 2.0e-02 | CFTR,KCNH1 | NA |
| SPAG9 | 9.00e-02 | other | NA | NA | 2.0e-02 | CDKN1A,FOXK1 | NA |
| RASSF7 | -4.50e-01 | other | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| CYP2C9 | -6.00e-01 | enzyme | NA | NA | 2.0e-02 | CCND1,DUSP1 | NA |
| IRX1 | 9.10e-01 | transcription regulator | NA | NA | 2.0e-02 | BDKRB2,FGF7 | NA |
| 2,5-di-tert-butylhydroquinone | NA | chemical toxicant | NA | NA | 2.0e-02 | ASNS,EIF1 | NA |
| methoxyacetic acid | NA | chemical toxicant | NA | NA | 2.0e-02 | PDE4D,PLK1 | NA |
| CGP 12177 | NA | chemical reagent | NA | NA | 2.0e-02 | UCP2,UCP3 | NA |
| pirenzepine | NA | chemical drug | NA | NA | 2.0e-02 | CHRM1,NOS1 | NA |
| 10-decarbamoylmitomycin C | NA | chemical toxicant | NA | NA | 2.0e-02 | CDKN1A,GADD45A | NA |
| taprostene | NA | chemical reagent | NA | NA | 2.0e-02 | CDKN1C,DUSP1 | NA |
| BRF110 | NA | chemical reagent | NA | NA | 2.0e-02 | GCH1,TH | NA |
| alpha-ergocryptine | NA | chemical toxicant | NA | NA | 2.0e-02 | PAQR7,PAQR8 | NA |
| raffinose | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | AKR1B1,ICAM1 | NA |
| desogestrel | NA | chemical drug | NA | NA | 2.0e-02 | INHA,SRD5A1 | NA |
| HOXD13 | NA | transcription regulator | NA | NA | 2.0e-02 | ANGPT1,FBN2,NT5E,RET,TNC | NA |
| RPA1 | -8.30e-01 | other | NA | NA | 2.0e-02 | Abi3bp,ADGRG5,FOCAD,HSPA1A/HSPA1B,SNCAIP | NA |
| Vhl | NA | complex | NA | NA | 2.0e-02 | BIRC2,CCND1,INHBB | NA |
| XMU-MP-1 | NA | chemical drug | NA | NA | 2.0e-02 | ESR1,GREB1,HMGCS1 | NA |
| N6-benzoyl-cAMP | NA | chemical reagent | NA | NA | 2.0e-02 | GJA1,NR4A2,NR4A3 | NA |
| N-Cadherin | NA | group | NA | NA | 2.0e-02 | CCND1,CDKN1A,SOX11 | NA |
| ARID3B | 5.40e-01 | transcription regulator | NA | NA | 2.0e-02 | BCL2L11,TNFSF10,TRADD | NA |
| TRPC4AP | 1.60e-01 | transporter | NA | NA | 2.0e-02 | BZW2,NOP56,SLC25A21 | NA |
| GSK0660 | NA | chemical reagent | NA | NA | 2.0e-02 | FBXO32,THBS1,TRIM63 | NA |
| NFE2L3 | 8.90e-01 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A,IL33,NQO1 | NA |
| HINT1 | 2.00e-02 | enzyme | NA | NA | 2.0e-02 | ELOVL5,FADS1,TPSAB1/TPSB2 | NA |
| MCL1 | NA | transporter | NA | NA | 2.0e-02 | CCND1,NQO1,TPT1 | NA |
| RLN1 | NA | other | NA | NA | 2.0e-02 | AQP3,ESR1,OXTR | NA |
| SCNN1A | 7.60e-01 | ion channel | NA | NA | 2.0e-02 | HSPA5,KCNJ1,SCNN1G | NA |
| LPA | NA | other | NA | NA | 2.0e-02 | ICAM1,SERPINB2,SERPINE1 | NA |
| SNW1 | 3.30e-01 | transcription regulator | NA | NA | 2.0e-02 | CCND1,CDKN1A,SERPINE1 | NA |
| SULF1 | 2.40e-01 | enzyme | NA | NA | 2.0e-02 | Acan,CCND1,COL2A1 | NA |
| RACGAP1 | 1.30e-01 | transporter | NA | NA | 2.0e-02 | CDKN1A,HOXB7,JUN | NA |
| Duxbl1 | NA | transcription regulator | NA | NA | 2.0e-02 | Oas1b,OAS2,Oasl2 | NA |
| raclopride | NA | chemical drug | NA | NA | 2.0e-02 | GRIN1,NR4A2,NR4A3 | NA |
| 5-nitro-2-(3-phenylpropylamino)benzoic acid | NA | chemical reagent | NA | NA | 2.0e-02 | CCND1,CLCN3,CLCN5 | NA |
| aplidine | NA | biologic drug | NA | NA | 2.0e-02 | DUSP1,FOSL1,JUN | NA |
| melanotan-II | NA | chemical drug | NA | NA | 2.0e-02 | SIM1,UCP2,UCP3 | NA |
| BRAF | 9.10e-01 | kinase | NA | NA | 3.0e-02 | ATF4,B4GAT1,BCL2L11,BIRC2,CCND1,CD86,CDKN1A,COL11A2,COL18A1,CPM,EPAS1,EXT2,FGF7,GALNT3,ICAM1,JUN,LAMB3,LAMC2,LOXL3,mir-154,MMP15,NRG1,NT5E,PCNA,POMK,RFFL,SDC1,SERPINE1,SLC6A14,THBS1,TNFRSF10A,TSC22D1,TSPAN1 | NA |
| RBM20 | -1.40e-01 | other | NA | NA | 3.0e-02 | ATM,ATP2A2,CARS1,CAV1,CHORDC1,CLIC4,DSP,EIF3C,EIF4E,HOPX,MSI2,MYPN,PKP2,PRKDC,SCN4B,TGFB2 | NA |
| HNRNPA2B1 | 3.20e-01 | other | NA | NA | 3.0e-02 | ADGRG2,CIDEC,DDR1,ELOVL7,FSCN1,GJA1,GPRC5B,INHBB,JUP,MAST4,MUC13,P4HA1,PBX1,PDE1A,PDGFC,SFI1,SLC6A14,TGFB2,VCAN,VIL1 | NA |
| glycochenodeoxycholate | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | BIRC2,MUTYH,NR0B2,TNFRSF10A | NA |
| CDH5 | 1.00e-01 | other | NA | NA | 3.0e-02 | CDKN1A,HMGCS1,ICAM1,TIAM1 | NA |
| pyrimidin-2-one beta-ribofuranoside | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A,CRYAA/LOC102724652,HSPA5,RASSF1 | NA |
| SOD1 | 1.30e-01 | enzyme | NA | NA | 3.0e-02 | ARL16,ATF1,ATF4,BAD,Casp12,CCND1,CKB,CNR1,GRIN1,H2-T24,HSPB8,ICAM1,IFI16,IFI44,IFIH1,IRF7,JUN,KCNJ2,Mt1,NETO2,NFIL3,NOS1,OAS2,PAWR,RBM3,RDX,SHANK2,SLFN13,SLFN5,SSTR1,TFRC,USP18,VAPA,VGF | NA |
| GPD1 | 1.00e-01 | enzyme | NA | NA | 3.0e-02 | ABCC4,Akr1b7,ASNS,CAMK2N2,CCND1,CGREF1,CPNE8,CYP39A1,GADD45A,GBP4,GPCPD1,MTHFD1L,NQO1,PRIMA1 | NA |
| MAFA | -1.90e-01 | transcription regulator | NA | NA | 3.0e-02 | ABCC8,CCL24,CDKN1A,CHRM1,CSF2RB,ESR1,FIGN,FLT3,GLP1R,GNA15,ICAM1,LARS2,NOS1,OXTR,PRKCD,PTGFR,SERPINE1,STEAP3,STK33,ZMIZ1 | NA |
| PER1 | 1.00e-02 | transcription regulator | NA | NA | 3.0e-02 | BCL2L11,CCND1,CCNE1,CRY1,LEP | NA |
| SIN3B | NA | transcription regulator | NA | NA | 3.0e-02 | FBXO32,GADD45B,NCL,RRM2,SRD5A1 | NA |
| SETBP1 | -2.50e-01 | transcription regulator | NA | NA | 3.0e-02 | BCL3,CARD11,CCND1,KCNJ5,KNL1,Meis1,NR4A3,PDGFB,STAT3,TNC,WRN,XPA | NA |
| SLC25A13 | NA | transporter | NA | NA | 3.0e-02 | ABCC4,Akr1b7,ASNS,CAMK2N2,CCND1,CGREF1,CPNE8,CYP39A1,GADD45A,GBP4,GPCPD1,MTHFD1L,NQO1,PRIMA1 | NA |
| TAF6 | -8.10e-01 | transcription regulator | NA | NA | 3.0e-02 | C11orf24,CDKN1A,GADD45A,IRF1,JUN,TTC32 | NA |
| POLDIP2 | NA | other | NA | NA | 3.0e-02 | HK2,KLF4,POLD1,SREBF1 | NA |
| GREM1 | 2.24e+00 | other | NA | NA | 3.0e-02 | AXIN2,CDKN1A,ELN,RET | NA |
| ZNF148 | 3.60e-01 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,DEPTOR,FDX1,RNLS,STAT1 | NA |
| APC/APC2 | NA | group | NA | NA | 3.0e-02 | CDKN1A,JUP,TRAF1 | NA |
| bendamustine | NA | chemical drug | NA | NA | 3.0e-02 | AURKA,CDKN1A,PLK1 | NA |
| Hoxa11os | NA | other | NA | NA | 3.0e-02 | IL18,NLRP3,STAT3 | NA |
| AAMDC | -1.30e-01 | other | NA | NA | 3.0e-02 | ASNS,ATF4,MTHFD1L | NA |
| ZBED2 | NA | transcription regulator | NA | NA | 3.0e-02 | IRF7,MX1,STAT2 | NA |
| FBXO42 | -2.40e-01 | other | NA | NA | 3.0e-02 | CCL5,ICAM1,STAT1 | NA |
| SETD1A | NA | ion channel | NA | NA | 3.0e-02 | CCND1,EZH2,PROM1 | NA |
| MEMO1 | -3.50e-01 | other | NA | NA | 3.0e-02 | CCND1,JUN,STC2 | NA |
| tryptase | NA | group | NA | NA | 3.0e-02 | CXCL10,F2R,PLAT | NA |
| SPTAN1 | -4.00e-02 | other | NA | NA | 3.0e-02 | CDKN1A,ITGA5,ITGAV | NA |
| TRG | NA | other | NA | NA | 3.0e-02 | CAV1,CAV2,NT5E | NA |
| DNM3OS | NA | other | NA | NA | 3.0e-02 | ATM,CHEK2,PRKDC | NA |
| mir-497 | NA | microRNA | NA | NA | 3.0e-02 | CCND1,CCNE1,CDC25A | NA |
| CTSZ | -1.00e-02 | peptidase | NA | NA | 3.0e-02 | CD83,CD86,LILRB4 | NA |
| ING4 | 7.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,CXCL10,NFKBIB | NA |
| OTUD7B | 3.50e-01 | peptidase | NA | NA | 3.0e-02 | ESR1,GREB1,ICAM1 | NA |
| PPM1A | 3.00e-01 | phosphatase | NA | NA | 3.0e-02 | CDKN1A,ITGA5,ITGAV | NA |
| YBX3 | 1.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CCND1,JUN,PCNA | NA |
| TKT | 1.00e-01 | enzyme | NA | NA | 3.0e-02 | CCND1,LEP,STAT3 | NA |
| CSNK1A1 | 2.60e-01 | kinase | NA | NA | 3.0e-02 | AXIN2,CCND1,CDKN1A | NA |
| cyclopentenone | NA | chemical reagent | NA | NA | 3.0e-02 | CCND1,HSPA1A/HSPA1B,ICAM1 | NA |
| prodigiosin | NA | chemical toxicant | NA | NA | 3.0e-02 | CDKN1A,HSPA5,RAD51 | NA |
| 5-iodotubercidin | NA | chemical - kinase inhibitor | NA | NA | 3.0e-02 | CCND1,LEF1,MYCN | NA |
| methylphenidate | NA | chemical drug | NA | NA | 4.0e-02 | AKR1B1,GCH1,NECTIN1,NUDT22,SAMD10,SNX22,Spin2c,TH,UBE3D | NA |
| Ro 25-6760 | NA | chemical toxicant | NA | NA | 4.0e-02 | CCNE1,CDKN1A | NA |
| inecalcitol | NA | chemical drug | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| QC6352 | NA | chemical reagent | NA | NA | 4.0e-02 | CXCL10,CXCL11 | NA |
| chondroitin sulfate B | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CXCL10,ICAM1 | NA |
| SKA3 | 3.70e-01 | other | NA | NA | 4.0e-02 | HK2,PLK1 | NA |
| colfosceril palmitate | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CXCL10,ICAM1 | NA |
| tozasertib | NA | chemical drug | NA | NA | 4.0e-02 | AURKA,CDKN1A | NA |
| GBP5 | -7.10e-01 | enzyme | NA | NA | 4.0e-02 | IL18,NLRP3 | NA |
| CINP | 1.80e-01 | other | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| Snhg6 | NA | other | NA | NA | 4.0e-02 | CCND1,CCNE1 | NA |
| MINDY1 | NA | peptidase | NA | NA | 4.0e-02 | ESR1,GREB1 | NA |
| SOCS2-AS1 | NA | other | NA | NA | 4.0e-02 | ACSL3,TNFSF10 | NA |
| ZFP42 | NA | transcription regulator | NA | NA | 4.0e-02 | CCND1,MAP2K3 | NA |
| CYTH2 | 1.10e-01 | other | NA | NA | 4.0e-02 | ARF6,PROX1 | NA |
| HSPBP1 | 3.30e-01 | other | NA | NA | 4.0e-02 | HSPA1A/HSPA1B,HSPA2 | NA |
| RS1 | NA | other | NA | NA | 4.0e-02 | GNAT1,RGS9 | NA |
| MYBPC3 | 4.10e-01 | other | NA | NA | 4.0e-02 | ATP2A2,CXCL10 | NA |
| ASCC1 | -8.20e-01 | transcription regulator | NA | NA | 4.0e-02 | BIRC2,TNFSF10 | NA |
| USP35 | 3.30e-01 | peptidase | NA | NA | 4.0e-02 | CCND1,GREB1 | NA |
| RETREG1 | NA | other | NA | NA | 4.0e-02 | ATF4,HSPA5 | NA |
| ATMIN | 7.20e-01 | transcription regulator | NA | NA | 4.0e-02 | MUTYH,OGG1 | NA |
| MUCL1 | NA | other | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| NKAP | -2.20e-01 | transcription regulator | NA | NA | 4.0e-02 | SLC7A11,ST8SIA6 | NA |
| DACT3 | -3.00e-01 | other | NA | NA | 4.0e-02 | AXIN2,CCND1 | NA |
| Sapk | NA | group | NA | NA | 4.0e-02 | FBXO32,GADD45A | NA |
| asparagine | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | ASNS,OAZ1 | NA |
| pertuzumab | NA | biologic drug | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| danusertib | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A,GADD45A | NA |
| TRDN | 1.90e-01 | other | NA | NA | 4.0e-02 | ASPH,JPH1 | NA |
| DIO1 | -5.50e-01 | enzyme | NA | NA | 4.0e-02 | SLC16A1,UCP3 | NA |
| N-docosahexaenoylethanolamine | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | ESR1,JUN | NA |
| IBSP | NA | other | NA | NA | 4.0e-02 | ITGAV,THBS1 | NA |
| CLIP1 | NA | other | NA | NA | 4.0e-02 | ICAM1,PCNA | NA |
| GRPR | -5.00e-02 | G-protein coupled receptor | NA | NA | 4.0e-02 | CDKN1A,MYCN | NA |
| mir-216 | NA | microRNA | NA | NA | 4.0e-02 | HK2,YBX1 | NA |
| ANKH | 0.00e+00 | transporter | NA | NA | 4.0e-02 | COL2A1,WNT5A | NA |
| TOP3A | -6.10e-01 | enzyme | NA | NA | 4.0e-02 | BLM,CDKN1A | NA |
| TIAM1 | -1.01e+00 | other | NA | NA | 4.0e-02 | JUN,LEF1 | NA |
| RAB11A | -2.00e-01 | enzyme | NA | NA | 4.0e-02 | SCARB1,SLC2A5 | NA |
| BOP1 | 6.70e-01 | other | NA | NA | 4.0e-02 | BOP1,CDKN1A | NA |
| GALR1 | 4.40e-01 | G-protein coupled receptor | NA | NA | 4.0e-02 | CCND1,CDKN1C | NA |
| STK16 | 6.00e-02 | kinase | NA | NA | 4.0e-02 | ATXN1,SERPINE1 | NA |
| AHNAK | -4.70e-01 | other | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| NASP | 3.10e-01 | other | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| anatabine | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | IL18,IL1R2 | NA |
| CHRM4 | 1.00e-02 | G-protein coupled receptor | NA | NA | 4.0e-02 | ITGA5,ITGAV | NA |
| KLK6 | 0.00e+00 | peptidase | NA | NA | 4.0e-02 | ADAM10,BCL2L11 | NA |
| CTNNAL1 | -1.10e-01 | other | NA | NA | 4.0e-02 | CCND1,ITGAV | NA |
| FER | -5.00e-01 | kinase | NA | NA | 4.0e-02 | B4GAT1,PRKCD | NA |
| TRPV5 | 1.00e-02 | ion channel | NA | NA | 4.0e-02 | S100G,TRPV6 | NA |
| C8orf44-SGK3/SGK3 | -9.70e-01 | kinase | NA | NA | 4.0e-02 | ATF4,ESR1 | NA |
| DDX19B | NA | enzyme | NA | NA | 4.0e-02 | ATM,CHEK2 | NA |
| ATP2A1 | 1.10e-01 | transporter | NA | NA | 4.0e-02 | ATP2A2,HSPA5 | NA |
| PTP4A2 | 4.20e-01 | phosphatase | NA | NA | 4.0e-02 | BCAR1,VCL | NA |
| BICD2 | -1.60e-01 | other | NA | NA | 4.0e-02 | CXCL10,STAT1 | NA |
| ELOA | 1.70e-01 | transcription regulator | NA | NA | 4.0e-02 | CCNE1,CDKN1A | NA |
| YWHAE | 3.30e-01 | other | NA | NA | 4.0e-02 | ATXN1,FOSL1 | NA |
| FOXL1 | NA | transcription regulator | NA | NA | 4.0e-02 | SDC1,WNT5A | NA |
| 2-[[4-[(e)-styryl]phenoxy]methyl]oxirane | NA | chemical reagent | NA | NA | 4.0e-02 | NR1H3,SREBF1 | NA |
| VSNL1 | -4.60e-01 | other | NA | NA | 4.0e-02 | ITGA5,ITGAV | NA |
| COL1A2 | NA | other | NA | NA | 4.0e-02 | CDKN1A,SERPINE1 | NA |
| CFL1 | 5.70e-01 | other | NA | NA | 4.0e-02 | ICAM1,JUN | NA |
| IL20RA | 4.00e-01 | transmembrane receptor | NA | NA | 4.0e-02 | ICAM1,IL18 | NA |
| SLC9A3R2 | 2.10e-01 | transporter | NA | NA | 4.0e-02 | CCND1,SCARB1 | NA |
| HMGN2 | NA | other | NA | NA | 4.0e-02 | CISH,IER3 | NA |
| S100A11 | 5.90e-01 | other | NA | NA | 4.0e-02 | ADAMTS4,CDKN1A | NA |
| MK-8776 | NA | chemical drug | NA | NA | 4.0e-02 | CDC25A,RRM2 | NA |
| phenylacetate | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CAV1,CAV2 | NA |
| NSC719239 | NA | chemical drug | NA | NA | 4.0e-02 | ITGA2,ITGA5 | NA |
| tirapazamine | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A,RPA1 | NA |
| ascomycin | NA | chemical reagent | NA | NA | 4.0e-02 | CD83,CD86 | NA |
| liarozole | NA | chemical drug | NA | NA | 4.0e-02 | TGM1,VDR | NA |
| chlorothiazide | NA | chemical drug | NA | NA | 4.0e-02 | S100G,TRPV6 | NA |
| LY117018 | NA | chemical drug | NA | NA | 4.0e-02 | ELN,THBD | NA |
| methyl cellosolve | NA | chemical reagent | NA | NA | 4.0e-02 | PDE4D,PLK1 | NA |
| phenanthridine | NA | chemical toxicant | NA | NA | 4.0e-02 | CD83,CD86 | NA |
| ruthenium red | NA | chemical reagent | NA | NA | 4.0e-02 | AQP5,COL2A1 | NA |
| NUP98-HOXD13 | NA | fusion gene/product | NA | NA | 4.0e-02 | PRKDC,XRCC4 | NA |
| atosibanum | NA | biologic drug | NA | NA | 4.0e-02 | CDKN1A,GJA1 | NA |
| myristoylated protein kinase C peptide inhibitor | NA | biologic drug | NA | NA | 4.0e-02 | CD55,TH | NA |
| 5R,11R-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol | NA | chemical reagent | NA | NA | 4.0e-02 | ESR1,TGFBR3 | NA |
| phosphorus | NA | chemical reagent | NA | NA | 4.0e-02 | CYP27B1,S100G | NA |
| N-butyldeoxynojirimycin | NA | chemical drug | NA | NA | 4.0e-02 | ICAM1,PAWR | NA |
| 4alpha-phorbol 12,13-didecanoate | NA | chemical reagent | NA | NA | 4.0e-02 | AQP5,COL2A1 | NA |
| thymeleatoxin | NA | chemical toxicant | NA | NA | 4.0e-02 | CD55,CDKN1A | NA |
| Co2+ | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CA9,NDRG1 | NA |
| FAM3B | 1.30e-01 | cytokine | NA | NA | 4.0e-02 | CAV1,CDKN1A,GJA1,IER3,ITGA5 | NA |
| MPZ | -3.00e-02 | other | NA | NA | 4.0e-02 | ATF4,FDFT1,HMGCS1,HSPA5,JUN | NA |
| ELK4 | -2.40e-01 | transcription regulator | NA | NA | 4.0e-02 | EGR2,EGR3,FOSL1,IL18,NCOA7 | NA |
| COL1A1 | 1.60e-01 | other | NA | NA | 4.0e-02 | CDKN1A,CLIC4,ICAM1,PCNA | NA |
| mir-194 | NA | microRNA | NA | NA | 4.0e-02 | GYG1,SLC7A5,SOCS2,THBS1 | NA |
| spermidine | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | AMD1,CDKN1A,HSPA5,OAZ1 | NA |
| Nuclear factor 1 | NA | group | NA | NA | 4.0e-02 | Akr1b7,FABP7,HSD17B7,LOX,S100G,TNFSF18 | NA |
| NSD2 | -4.50e-01 | enzyme | NA | NA | 4.0e-02 | CDC25A,GADD45A,HDAC4,IRF7,JUN,STAT1,STAT3 | NA |
| RNA polymerase II | NA | complex | NA | NA | 5.0e-02 | ANGPTL4,ASNS,AURKA,CCL5,CD83,CDKN1A,CHEK2,CISH,DDX11,DUSP1,ESR1,FOSL1,GADD45A,GADD45B,HNF1A,HSPA1A/HSPA1B,ICAM1,Ifi47,ITGA5,JUN,L1CAM,MAD2L1,MCM3,Meis1,Mt1,MYBL2,MYCN,NMD3,NR1H4,PBX1,PCNA,SLC36A4,TRPV6 | NA |
| belinostat | NA | chemical drug | NA | NA | 5.0e-02 | BCL2L11,CDKN1A,RAD52 | NA |
| Stat1-Stat2 | NA | complex | NA | NA | 5.0e-02 | IRF1,IRF7,TLR3 | NA |
| DBH-AS1 | NA | other | NA | NA | 5.0e-02 | CCND1,CCNE1,CDKN1A | NA |
| HJURP | -3.90e-01 | other | NA | NA | 5.0e-02 | CCND1,CCNE1,CDKN1A | NA |
| ZGPAT | 7.00e-02 | transcription regulator | NA | NA | 5.0e-02 | CDC25A,PDGFB,RGS3 | NA |
| TLR2/3/4/9 | NA | group | NA | NA | 5.0e-02 | CD83,CD86,ICAM1 | NA |
| DAZ2 | NA | translation regulator | NA | NA | 5.0e-02 | INHA,INHBB,TFCP2L1 | NA |
| TRPM8 | 6.40e-01 | ion channel | NA | NA | 5.0e-02 | HSPA1A/HSPA1B,RBM3,UCP3 | NA |
| BCO2 | NA | enzyme | NA | NA | 5.0e-02 | HTATIP2,NR1D1,SPON2 | NA |
| CAVIN1 | NA | transcription regulator | NA | NA | 5.0e-02 | ATM,CDKN1A,ITGAX | NA |
| cercosporin | NA | chemical - endogenous non-mammalian | NA | NA | 5.0e-02 | AXIN2,CCND1,CDC25A | NA |
| GFPT1 | 1.40e-01 | enzyme | NA | NA | 5.0e-02 | LEP,THBS1,TK1 | NA |
| PDGFA | 1.60e-01 | growth factor | NA | NA | 5.0e-02 | ELN,FGF7,PROM1 | NA |
| PKP2 | -1.27e+00 | other | NA | NA | 5.0e-02 | COL2A1,DSP,GJA1 | NA |
| NMNAT1 | -4.00e-02 | enzyme | NA | NA | 5.0e-02 | RAPGEF4,SOCS2,TGFB2 | NA |
| WZ-4002 | NA | chemical drug | NA | NA | 5.0e-02 | BAD,BCL2L11,HK2 | NA |
| MLH1 | -1.06e+00 | enzyme | NA | NA | 5.0e-02 | CCND1,MLH1,RAD51 | NA |
| PEA15 | 2.30e-01 | transporter | NA | NA | 5.0e-02 | EGR2,JUN,PLD2 | NA |
| DHH | 4.40e-01 | peptidase | NA | NA | 5.0e-02 | ADAMTS1,GJA1,HHIP | NA |
| CDKN1C | -7.90e-01 | other | NA | NA | 5.0e-02 | CCND1,CDKN1C,PARP1 | NA |
| NEK2 | NA | kinase | NA | NA | 5.0e-02 | CDKN1A,GADD45A,MYO18A | NA |
| Sik1 | 4.20e-01 | kinase | NA | NA | 5.0e-02 | DIO2,DUSP1,SREBF1 | NA |
| capivasertib | NA | chemical drug | NA | NA | 5.0e-02 | AXIN2,PROM1,TGM2 | NA |
| RECK | 3.20e-01 | other | NA | NA | 5.0e-02 | CCND1,CDKN1A,SKP2 | NA |
| PRKCH | -1.30e-01 | kinase | NA | NA | 5.0e-02 | CCND1,CDKN1A,TGM1 | NA |
| INCB054329 | NA | chemical drug | NA | NA | 5.0e-02 | CCND1,JAK2,STAT3 | NA |
| SS18-SSX1 | NA | fusion gene/product | NA | NA | 5.0e-02 | AXIN2,CCND1,CDC25A | NA |
| 2,4-dinitrobenzenesulfonic acid | NA | chemical reagent | NA | NA | 5.0e-02 | CD86,ICAM1,SCARB1 | NA |
| diazooxonorleucine | NA | chemical drug | NA | NA | 5.0e-02 | AGT,SREBF1,THBS1 | NA |
| NTRK1 | 1.20e-01 | kinase | NA | NA | 5.0e-02 | CDKN1A,GADD45A,RET,TSC22D1,WNT5A | NA |
Adrenal %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S10. Ingenuity upstream regulators predicted to have similar activatory or inhibitory effect to ozone in Adrenal - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))read_excel("../input_files/Upstream/Liver_upstream analysis.xls") %>% row_to_names(row_number=1) -> Liver## New names:
## • `` -> `...2`
## • `` -> `...3`
## • `` -> `...4`
## • `` -> `...5`
## • `` -> `...6`
## • `` -> `...7`
## • `` -> `...8`as.numeric(Liver$`Activation z-score`) -> Liver$`Activation z-score`
Liver <- Liver[order(-Liver$`Activation z-score`),]
as.numeric(Liver$`Expr Log Ratio`) -> Liver$`Expr Log Ratio`
as.numeric(Liver$`p-value of overlap`) -> Liver$`p-value of overlap`
Liver %>%
mutate(
`Expr Log Ratio`=format(round(`Expr Log Ratio`,2),nsmall=2,scientific=TRUE),
`Activation z-score`=format(round(`Activation z-score`,2),nsmall=2,scientific=TRUE),
`p-value of overlap`=format(round(`p-value of overlap`,2),nsmall=2,scientific=TRUE)) %>%
kable(caption = "Supplementary Table S8. Ingenuity upstream regulators predicted to have similar activatory or inhibitory effect to ozone in Liver", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(1:8,bold=ifelse(is.na(Liver$`Predicted Activation State`),F,T),color= ifelse(is.na(Liver$`Predicted Activation State`),"gray",ifelse(Liver$`Predicted Activation State` == "Inhibited","#40004B","#00441B"))) %>%
scroll_box(width = "1200px", height = "500px")| Upstream Regulator | Expr Log Ratio | Molecule Type | Predicted Activation State | Activation z-score | p-value of overlap | Target Molecules in Dataset | Mechanistic Network |
|---|---|---|---|---|---|---|---|
| methylprednisolone | NA | chemical drug | Activated | 7.92e+00 | 0.0e+00 | ADGRL2,ADRA1B,APEX1,ARG1,ARL4A,ASNS,ASPA,ASS1,ATP1B1,AZIN1,B4GALNT1,BAIAP2,CBLB,CCND1,CCNG1,CD180,Cd24a,CD79B,CDKN1A,CLDN3,CREM,DDIT4,DUSP6,DYNLL1,EDNRB,EFNA1,EPHX2,FABP7,FDFT1,FGR,Fn3k,FOXA1,FOXA2,GBP2,GCK,GCLM,GNL3,Gnmt,GOT1,GSTT2/GSTT2B,HSD17B2,Hsd3b4 (includes others),HSPH1,ID3,IGFALS,IGFBP1,IL1RN,IL6R,INSIG1,IRF1,ITPR1,JUN,KLF15,KLF9,LAMA3,LDLR,LGALS9B,LRP3,LYN,MAFB,MAP1LC3B,Mx2,MYO1B,NFE2L2,NFYB,NOLC1,NR3C1,ODC1,PCYT1A,PDE3B,PER2,PEX11A,PIK3R1,PIM3,POLG2,POR,PPL,PPP2CA,PSAT1,PTPN1,RB1,RND3,RNF4,SDC4,SDS,SEPHS2,SERPINB9,SERPINE1,SIRPA,SLC16A6,SLC25A30,SLC7A2,STAT3,SULT1B1,SULT1C3,SYK,TDO2,TFRC,THRB,TINAGL1,TLR6,TNFAIP3,TNK2,TOMM20,Tsc22d3,UBE2G2,USP2,VMP1,Wasl,ZFP36L1,ZNF354A | 467 (24) |
| dexamethasone | NA | chemical drug | Activated | 4.57e+00 | 0.0e+00 | AACS,ACKR4,ADAMTS1,AGT,AKR1C4,ALPL,ARHGAP24,ARHGEF19,ASNS,ATF3,ATOH8,ATP1B1,ATP6V1B2,BCL2L11,BCL3,BHLHE40,BHMT,BIRC2,BIRC3,BTG2,C12orf42,C9orf72,CBLB,CCND1,CCND2,CCNE1,CCNJ,CD274,CDKN1A,CEBPB,Ces2/Ces2c,CIDEC,CISH,CMPK2,CNTF,CYP26A1,DBT,DDIT4,DEXI,DFFB,DHCR24,DLL1,EDEM1,EDNRA,EDNRB,EFNA1,EGF,ELAVL1,ENC1,EPB41,ERLIN1,ETNPPL,ETV5,EXT1,FANCB,FASN,FKBP5,FOXO1,GADD45B,GBP2,GCK,GCLM,GDF15,GFOD2,GOLIM4,GOT1,GTF2IRD1,HDAC2,HELZ2,HERPUD1,HSPH1,ID2,IFI44,IFIT3,IFRD1,IGFALS,IGFBP1,IHH,IL15,IL17RB,IL1RL2,IL1RN,IL33,IL6R,INHBA,IRF1,IRF2BP2,ITPKA,ITPR1,JUN,KLF15,KLF9,KLRD1,KPNA2,LAMA3,LAMC1,LDLR,LIMK2,LMO4,LPAR6,LPIN1,LRRC8A,LYN,LYSMD2,MAF,MAP2K6,MAP3K5,MAPK6,MAT1A,MEGF9,MID1IP1,MRPL47,MSLN,MTHFD1,MX1,N4BP2L1,NCOA4,NET1,NFKBIZ,NLRP3,NR3C1,NREP,NRIP1,ODC1,P2RY10,P4HA1,PAH,PARP14,PATZ1,PCSK6,PCSK9,PER1,PER2,PFKFB2,PFKFB3,PIK3IP1,PIK3R1,PKP2,PLD1,PNPLA2,POR,PPARD,PPARGC1A,PPL,PREP,PRKAG2,PRRG4,PTK6,RARRES1,RB1,RBP7,RFX5,RGS1,ROR1,RSAD2,RTP4,S1PR1,SDS,SEC22B,SELENBP1,SERPINB9,SERPINE1,SFSWAP,SLC10A6,SLC19A2,SLC25A22,SLC25A33,SLC25A34,SLC30A2,SLC38A4,SLC45A3,SLC8B1,SMARCD2,SOCS2,SPECC1,SPON2,SPSB1,SRSF4,SSBP3,ST3GAL5,STOM,SULT1B1,Sult1c2/Sult1c2a,SULT1C3,SYK,TAT,TDO2,TFRC,TGFB1,TK1,TMEM140,TNFAIP3,TNFRSF11B,TNS1,TRPM6,TSC22D1,Tsc22d3,TSPYL4,UBC,UGP2,USP2,VCAN,VMP1,WNT4,XBP1,ZC3H12A,ZFP36L1,ZNF189,ZNF750 | 532 (20) |
| Ttc39aos1 | NA | other | Activated | 3.90e+00 | 0.0e+00 | Apol9a/Apol9b,ATP10A,DTX3L,GBP2,IFI44,IFIT3,Igtp,IRF1,Mx2,Oas1b,OAS2,PARP14,PARP9,PYCARD,RSAD2,RTP4,SERPINE1,TRIM6-TRIM34,ZNFX1 | 105 (7) |
| Gcg | NA | other | Activated | 3.64e+00 | 0.0e+00 | AGXT,ARG1,ASL,ASS1,ATP1B1,CYP17A1,ETNPPL,MAT1A,MFSD2A,NNMT,PEX11A,PPARGC1A,RARRES1,SDS,SLC25A15,SLC7A2,TFRC | 207 (9) |
| IL1RN | 9.30e-01 | cytokine | Activated | 3.64e+00 | 0.0e+00 | ATF3,CDKN1A,CNTF,CXCL11,CYP7A1,IFI44,IFI44L,IFIT3,IRF1,MX1,OAS2,RARRES1,RSAD2,RTP4,SERPINE1,TCF7L2,ZNF81 | 373 (15) |
| STAG2 | -2.30e-01 | other | Activated | 3.30e+00 | 0.0e+00 | CD274,CMPK2,CXCL11,GBP2,HELZ2,IFI44,IFI44L,IFIT3,PARP14,PARP9,RSAD2 | NA |
| TREX1 | 2.00e-02 | enzyme | Activated | 3.24e+00 | 0.0e+00 | CD274,CDKN1A,CMPK2,DTX3L,HELZ2,IFI44,IFI44L,IFIT3,IL15,IL33,IRF1,LGALS9B,MX1,Mx2,NLRP3,OAS2,PARP14,PARP9,PLA2G4A,RSAD2,RTP4,TLR6,TNFAIP3 | 149 (12) |
| NR3C1 | -8.10e-01 | ligand-dependent nuclear receptor | Activated | 3.15e+00 | 0.0e+00 | AGT,ATP1B1,BCL2L11,BHLHE40,BIRC2,BIRC3,BRWD1,CARD10,CCND1,CD274,CDKN1A,CEBPB,CIDEC,CLCF1,CPT1A,CYP7A1,DBT,DDIT4,DYNLL1,EFNA1,ENC1,FKBP5,FOXO1,GADD45B,GBP2,GCLM,HDAC2,HERPUD1,HNF4A,Hsd3b4 (includes others),IGFALS,IGFBP1,IL15,IL15RA,IL33,INHBA,IRF1,JUN,KLF9,LMO4,LPIN1,LRRC8A,LYST,MAP3K14,MAT1A,MFSD2A,MKNK2,Mt1m/Mt2A,MTHFD1,NLRP3,NR3C1,ONECUT1,PAWR,PER1,PFKFB3,PIK3R1,PIM3,PLA2G4A,PNPLA2,PPP2CA,RB1,RHOB,SDS,SERPINB9,SERPINE1,SGPL1,SLC19A2,SLC25A33,STAT3,STC1,STOM,TADA3,TAT,TGFB1,TK1,TNFAIP1,TNFAIP3,TNFRSF11B,TPST2,TRIM45,TUBA3E,WDR26,WDR3 | 495 (21) |
| FOXO3 | 1.10e-01 | transcription regulator | Activated | 3.13e+00 | 0.0e+00 | Acot1,APEX1,AURKA,BCL2L11,CCND1,CCND2,CDKN1A,CDT1,CLDN1,DDIT4,EDNRB,FASN,FGFR2,FOXO1,GADD45B,IGFBP1,INHBA,MAP1LC3B,NCAPD2,NOLC1,NRP2,NUPR1,PAWR,PCSK9,PDE3B,PIK3IP1,PPARGC1A,Rcan1,SERPINE1,SLC1A4,SOX5,TGFB1,TP53INP1,UBC | 458 (25) |
| RNASEH2B | -9.00e-02 | other | Activated | 3.05e+00 | 0.0e+00 | CDKN1A,CMPK2,HELZ2,IFI44,IFI44L,IFIT3,Igtp,IL15,IRF1,MX1,NLRP3,OAS2,PARP14,PARP9,PYCARD,RSAD2,RTP4,TLR6,TNFAIP3 | 52 (4) |
| TRIM24 | NA | transcription regulator | Activated | 3.05e+00 | 0.0e+00 | Apol9a/Apol9b,CMPK2,GBP2,IFI44,Ifi47,IFIT3,Igtp,IRF1,Irgm1,RTP4,SERPINE1,SOCS2,TRIM6-TRIM34,TRPV6 | 225 (13) |
| FOXA2 | -1.35e+00 | transcription regulator | Activated | 3.01e+00 | 0.0e+00 | BIRC2,CCND1,CPT1A,CYP26A1,DDIT4,FOXA1,FOXA2,FOXO1,GCK,HNF1A,HNF4A,IGFBP1,IL33,MAFB,NR1I2,NR4A2,ONECUT1,SH3PXD2A,SLC10A6,SLCO1B3,SPSB1,TAT,TDO2,TGFB1 | 441 (21) |
| Irgm1 | -1.58e+00 | other | Activated | 2.90e+00 | 0.0e+00 | Apol9a/Apol9b,FAS,GBP2,ID2,ID3,IFI44,IFIT3,IRF1,Mx2,NUPR1,Oas1b,OAS2,Oasl2,RSAD2,TK1 | 314 (16) |
| PNPT1 | -4.00e-02 | enzyme | Activated | 2.89e+00 | 0.0e+00 | Apol9a/Apol9b,CDKN1A,CMPK2,GBP2,IFI44,IFIT3,Irgm1,Oas1b,Oasl2,PARP14,PARP9,RTP4,TOR3A | 301 (7) |
| bromobenzene | NA | chemical toxicant | Activated | 2.83e+00 | 0.0e+00 | BHMT,CDKN1A,EGF,FDFT1,FMO3,GOT1,HMGCS1,JUN,MSMO1,Mt1m/Mt2A,POR,TSC22D1 | NA |
| aldosterone | NA | chemical - endogenous mammalian | Activated | 2.79e+00 | 8.0e-02 | ADAMTS1,AGT,ATP1B1,FKBP5,NR3C1,PER1,PPARGC1A,PTPN1,SERPINE1,SLC12A3,TAT,TGFB1,USP2 | NA |
| MYC | -4.50e-01 | transcription regulator | Activated | 2.79e+00 | 0.0e+00 | ADAMTS1,ALDOA,AMD1,APEX1,ARG1,ASNS,ASS1,ATAD3A,AZIN1,BCL2L11,BIRC2,CCND1,CCND2,CCNE1,CD274,CDKN1A,CEP85,CHKA,CIDEC,CLDN1,CPT1A,CPT2,CXCL11,CYP26A1,DDB2,DDIT4,DFFB,DUSP6,EIF2B3,ELAVL1,FAS,FASN,FKBP5,FOXA2,GADD45B,GADD45G,GART,GBP2,GCK,GCLM,GOT1,HDAC2,HNRNPD,HSPH1,ID2,ID3,IFI44,IFI44L,IFIT3,IL17RB,INHBA,IRF6,ITPR1,JUN,LDLR,LIMA1,LYN,MTHFD1,MX1,MYO1B,NFE2L2,NOCT,NOLC1,NOP56,Oasl2,ODC1,PFKFB1,PFKFB3,POLG2,PPARD,PPL,PPP2CA,PREP,PSAT1,RARRES1,RB1,REN,RHOB,RPS18,RSAD2,SARDH,SCAMP5,SEPHS2,SERPINE1,SLC3A2,SLC7A5,SMOX,SOX5,SOX6,STAT3,SUMO3,SYCP3,TAT,TFRC,TGFB1,TGM1,UNC119,VMP1,WEE1,WWC1,XBP1,ZFP36L1 | 467 (23) |
| fluticasone propionate | NA | chemical drug | Activated | 2.77e+00 | 1.0e-02 | DDIT4,FKBP5,FSCN1,GADD45B,IL1RN,KLF9,MBL2,MX1,OAS2,PPARGC1A,RARRES1,SDC4,SERPINE1,SLC16A6,TGFB1,TSC22D1 | 399 (16) |
| ID2 | -7.60e-01 | transcription regulator | Activated | 2.76e+00 | 0.0e+00 | BCL2L11,BCL3,BIRC3,BTG2,CCND1,CCND2,CCNE1,CCNG1,CDKN1A,CEBPB,DLL1,DLL4,FAS,FOXO1,GADD45B,GADD45G,ID3,IL17RB,IL6R,IRF6,LMO4,LRIG1,MAF,MAP2K6,MAP3K14,PAWR,PIK3IP1,PIK3R1,RPRM,SOX5 | 361 (15) |
| AMPK | NA | complex | Activated | 2.73e+00 | 0.0e+00 | AACS,ACO2,BCL2L11,CCND2,CDKN1A,CLDN1,Esrra,FASN,FSCN1,IDH3A,IL1RN,LPIN1,NOX4,PFKFB3,PPARGC1A,SERPINE1,Tsc22d3 | 420 (22) |
| corticosterone | NA | chemical - endogenous mammalian | Activated | 2.71e+00 | 0.0e+00 | ATP1B1,CCND1,CDKN1A,CEBPB,CPT1A,CPT2,DBP,DDIT4,FASN,FKBP5,GCK,HIF3A,JUN,KLF9,MFSD2A,NOX4,NR3C1,PNPLA2,PPARGC1A,SERPINA7,SLC12A3,TAT,Tsc22d3,XBP1 | 450 (24) |
| PPARGC1A | 2.46e+00 | transcription regulator | Activated | 2.70e+00 | 0.0e+00 | ACO2,ADAMTS1,AGT,CDKN1A,CEBPB,CPT1A,CYP7A1,DLAT,Esrra,FAM20A,FAS,FASN,GADD45B,GDF15,IDH3A,IL1RN,INHBA,INSIG1,INSIG2,LDLR,LGALS9B,LPIN1,MAP2K6,MRPS31,MSI1,MSMO1,NFKBIZ,ODC1,PIK3R1,PLIN5,PNPLA2,PPARGC1A,PPARGC1B,SERPINA7,SESN2,SLC25A25,STAT3,STC1,TNFRSF11B,VCAN,WDR77,XBP1 | 451 (23) |
| PGR | -5.50e-01 | ligand-dependent nuclear receptor | Activated | 2.69e+00 | 0.0e+00 | ADAMTS1,AMD1,ARHGAP29,ATP1B1,BIRC2,BIRC3,CA12,CCND1,CDH23,CDKN1A,CDT1,CEBPB,CPT2,CREB3L2,DCHS1,DYNLL1,EDNRA,ELL2,ENC1,FKBP5,FOXO1,GOT1,IFI44,IFI44L,IFIT3,IGFBP1,IHH,KLF11,KLF9,MPHOSPH10,MTSS1,MX1,NET1,NPC1,OAS2,PFKFB3,PPIF,PTP4A1,RND3,RSAD2,SCUBE3,SERPINB8,SERPINE1,SLC7A5,STAT3,STC1,TAT,TBC1D8,TENM3,TGFB1,TK1,VCAN,WNT4,ZNF354A | 450 (21) |
| triamcinolone acetonide | NA | chemical drug | Activated | 2.67e+00 | 0.0e+00 | ACKR4,AGXT,ATF3,ATP10A,B4GALNT1,BCL2L11,BHLHE40,BTG2,CD79B,CHKA,CYTIP,EDNRA,EPHA4,FGFR2,FKBP5,INSIG1,JUN,KLF15,KLF9,LDLR,MEGF9,NR3C1,PALLD,PER1,PEX6,SOCS2,ST3GAL5,TAT,TCF7L2,ZNF189 | 341 (12) |
| bortezomib | NA | chemical drug | Activated | 2.62e+00 | 0.0e+00 | ALPL,ATF3,AURKA,BCL2L11,BIRC2,BIRC3,CCND1,CCND2,CDKN1A,DNAJA1,FAS,FOXO1,GADD45B,GDF15,HDAC2,IL33,INHBA,KLF9,MAPK6,MX1,NOX4,ODC1,RSAD2,SH3BP2,TGFB1,XBP1 | 396 (25) |
| NR4A3 | -9.00e-02 | ligand-dependent nuclear receptor | Activated | 2.58e+00 | 0.0e+00 | AASS,BIRC3,CCND1,CCND2,CDKN1A,FOXA2,FOXO1,LPIN1,PPARGC1A,PPARGC1B,SERPINE1 | 460 (23) |
| tosedostat | NA | chemical drug | Activated | 2.54e+00 | 0.0e+00 | ASNS,ASS1,ATF3,CBS/LOC102724560,CDKN1A,CEBPB,DDIT4,PSAT1,SESN2,SLC38A2 | NA |
| rosiglitazone | NA | chemical drug | Activated | 2.53e+00 | 0.0e+00 | ACO2,ADAMTS1,ADIPOR2,AGT,ARG1,CCND1,CDKN1A,CIDEC,CPT1A,CPT2,CXCL11,DHRS3,EDNRA,EPHX2,FASN,FOXA2,GBP2,GCK,GDF15,GOT1,GPAT3,IDH3A,IFIT3,IGFBP1,IL1RN,IL21R,INHBA,INSIG1,IRF1,KLF11,LPIN1,NOX4,OAS2,PEX11A,PIK3R1,PLIN5,PNPLA2,PPARGC1A,PPARGC1B,PTPN1,PTPRO,REN,SERPINE1,SPON2,TSC22D1 | 397 (20) |
| TET2 | 2.80e-01 | enzyme | Activated | 2.50e+00 | 2.0e-02 | ASPA,BCL2L11,BCL3,BHLHE40,CMPK2,FBXO15,IFIT3,MTSS1,RGS1,RND3,RNF144A,RSAD2,TGM1 | NA |
| Scd2 | -3.90e-01 | enzyme | Activated | 2.45e+00 | 0.0e+00 | CMPK2,HELZ2,IFIT3,OAS2,PARP14,RSAD2 | 143 (9) |
| SU6656 | NA | chemical toxicant | Activated | 2.45e+00 | 0.0e+00 | ATF3,CCND1,INHBA,NR4A2,TNFRSF11B,ZFP36L1 | 367 (18) |
| ACKR2 | 1.80e-01 | G-protein coupled receptor | Activated | 2.45e+00 | 2.0e-02 | IFI44,Ifi47,IFIT3,OAS2,Oasl2,RSAD2 | NA |
| ADIPOR1 | -2.00e-02 | transmembrane receptor | Activated | 2.44e+00 | 0.0e+00 | ARG1,CLEC10A,Esrra,FAS,PPARGC1A,PYCARD | 418 (24) |
| PTCH1 | -2.00e-01 | transmembrane receptor | Activated | 2.43e+00 | 0.0e+00 | BTG2,CCND1,DLL1,DLL4,IL33,MTSS1,SOX5 | 268 (5) |
| ZAP70 | 4.40e-01 | kinase | Activated | 2.43e+00 | 5.0e-02 | BCL2L11,DEXI,FKBP5,ITPR1,RBM3,TAT | NA |
| NPPB | NA | other | Activated | 2.42e+00 | 0.0e+00 | FDFT1,HMGCS1,LDLR,MSMO1,PPARGC1A,TGFB1 | 437 (12) |
| apatinib | NA | chemical drug | Activated | 2.38e+00 | 1.0e-02 | ASL,ASNS,ASS1,GOT1,SLC1A4,SLC3A2 | NA |
| forskolin | NA | chemical toxicant | Activated | 2.34e+00 | 0.0e+00 | ACER2,ADAMTS1,ADCY9,ADGRL2,AGL,ALDOA,ALPL,ATF3,ATP1B1,ATP6V1B2,BCL2L11,BCL3,BHLHE40,BTG2,CARD10,CCND1,CCND2,CDKN1A,CEBPB,CGREF1,CIDEC,CITED4,CREM,CYP17A1,DDIT4,DHRS3,DUOX2,DUSP6,ELL2,EPHA4,Esrra,FAS,FGFR2,FKBP5,FOXO1,GADD45B,GADD45G,GNA14,Hsd3b4 (includes others),ID2,ID3,IGFBP1,INHBA,ITPR1,JUN,MAP1LC3B,MAP3K5,MFSD2A,MSMO1,NPC1,NR4A2,ODC1,PAWR,PER1,PIM3,PPARGC1A,PPP1R3C,PPP2CA,PTP4A1,PTPN1,RASGEF1B,REN,RHOB,RNF4,RPRM,SERPINE1,STARD7,STAT3,STC1,STOM,TAT,TK1,TNFAIP3,TNFRSF11B,USH2A,VCAN,WNT4 | 382 (20) |
| Z36 | NA | chemical reagent | Activated | 2.33e+00 | 0.0e+00 | ASNS,CDKN1A,CEBPB,HERPUD1,INSIG1,MAP1LC3B,MAP1LC3B2,NUPR1,XBP1 | 268 (10) |
| CITED2 | 3.80e-01 | transcription regulator | Activated | 2.32e+00 | 0.0e+00 | ABTB2,ARG1,ARL4A,ASAP3,ATXN7L1,CD274,CLEC10A,CMPK2,DTX3L,EXT1,GADD45B,GBP2,IFI44,Ifi47,IFIT3,IFRD1,IL1RN,INPP5B,IRF1,Irgm1,LGALS9B,MAPK6,Mx2,Oasl2,PARP14,PARP9,PFKFB3,PRRG4,RGS1,RSAD2,RTP4,SECTM1,SLC38A2,TMEM140,TNFAIP3,TRIM6-TRIM34 | 231 (14) |
| niacinamide | NA | chemical - endogenous mammalian | Activated | 2.31e+00 | 0.0e+00 | CDKN1A,FASN,IL15,IRF1,NFYA,NFYB,NNMT,PINX1,RB1,SLC34A2,TOMM20,UBE2F | 303 (12) |
| progesterone | NA | chemical - endogenous mammalian | Activated | 2.29e+00 | 0.0e+00 | Acot1,ADAMTS1,ADCYAP1R1,AKR1C4,ALPL,AMD1,ANKH,ARL4A,ATF3,ATP1B1,ATP6V1B2,AURKA,BHLHE40,BIRC3,C9orf72,CA12,CAPRIN2,CCND1,CCNE1,CCNG1,CDKN1A,CDT1,CEBPB,CIDEC,CLDN3,CRCP,CREB3L2,CSF3R,CXCL11,CYP26A1,DBP,EDNRA,EFNA1,EGF,ELL2,ENC1,FGFR2,FKBP5,FOXO1,HAND2,HSD17B2,ID3,IGFBP1,IHH,IL15,IL33,IL6R,INHBA,JUN,KLF11,KLF9,LPIN1,LRP2,MPHOSPH10,MTSS1,MX1,NET1,NPC1,NUPR1,OSGIN1,PER2,PFKFB3,PIK3R1,PLIN4,PPP2CA,PTGER3,PYCARD,RAB11FIP5,REM1,SPSB1,STAT3,TAT,TBC1D8,TCF7L2,TDO2,TGFB1,TGM1,TK1,WNT4,ZNF354A | 487 (23) |
| berberine | NA | chemical drug | Activated | 2.29e+00 | 2.0e-02 | BIRC2,BIRC3,CCND1,CDKN1A,CPT1A,CYP7A1,FAS,LDLR,PCSK9,PPARD,TGFB1 | NA |
| IRGM | NA | enzyme | Activated | 2.27e+00 | 0.0e+00 | CMPK2,HELZ2,IFI44,IFI44L,IFIT3,MAP3K6,MAPK11,MX1,OAS2,RSAD2,TNFAIP3 | 180 (7) |
| CD276 | 6.00e-02 | other | Activated | 2.24e+00 | 1.0e-02 | CXCL11,IRF1,MX1,OAS2,SOCS2 | 348 (15) |
| LILRB4 | 2.50e-01 | other | Activated | 2.24e+00 | 2.0e-02 | CD79B,CSF3R,CXCL11,FAS,KLRD1 | NA |
| H1-6 | NA | other | Activated | 2.24e+00 | 3.4e-01 | BCL3,BHMT,CYTH1,DOT1L,SF3A1 | NA |
| H1f1 | NA | other | Activated | 2.24e+00 | 3.4e-01 | BCL3,BHMT,CYTH1,DOT1L,SF3A1 | NA |
| PPIF | 7.40e-01 | enzyme | Activated | 2.24e+00 | 4.2e-01 | ACKR4,MEIS2,PDZRN3,RGS3,SPON2 | NA |
| 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone | NA | chemical reagent | Activated | 2.22e+00 | 0.0e+00 | CCND1,CCND2,CCNE1,CDKN1A,RB1 | 242 (7) |
| AMP | NA | chemical - endogenous mammalian | Activated | 2.22e+00 | 0.0e+00 | ETNPPL,FOXO1,MFSD2A,PIK3R1,SLC25A25 | NA |
| DUSP11 | -2.10e-01 | phosphatase | Activated | 2.22e+00 | 0.0e+00 | CMPK2,IFI44,IFIT3,Oasl2,RSAD2 | 114 (7) |
| cis-urocanic acid | NA | chemical drug | Activated | 2.22e+00 | 0.0e+00 | ADAMTS1,CLDN1,GADD45B,PPIF,TNFAIP3 | 138 (7) |
| ADAM12 | -2.70e-01 | peptidase | Activated | 2.21e+00 | 2.5e-01 | C1QTNF3,CEBPB,GDF15,IL33,SERPINE1 | NA |
| GNA11 | 1.00e-02 | enzyme | Activated | 2.20e+00 | 0.0e+00 | ADAMTS1,ALPL,CCNG1,HAND2,KLF15 | NA |
| GC-GCR dimer | NA | complex | Activated | 2.19e+00 | 0.0e+00 | AGT,BCL2L11,IL1RN,PFKFB1,PIK3R1,TAT | NA |
| 1-methyl-4-phenylpyridinium | NA | chemical toxicant | Activated | 2.18e+00 | 1.0e-02 | BACH1,BCL2L11,CCND1,DDIT4,TFRC | 424 (23) |
| lapatinib | NA | chemical drug | Activated | 2.17e+00 | 3.0e-02 | BCL2L11,ETV5,HNF4A,JUN,MAP1LC3B | NA |
| PD173074 | NA | chemical reagent | Activated | 2.15e+00 | 3.0e-02 | CCND1,CCND2,CEBPB,DUSP6,EFNA1,MAFK,NUPR1,PPARD | NA |
| GCG | NA | other | Activated | 2.14e+00 | 0.0e+00 | BTG2,CBS/LOC102724560,CEBPB,CPT1A,CYP7A1,ETNPPL,FASN,FOXA2,GREM2,IGFBP1,LIMA1,LPIN1,NFYA,NFYB,NR3C1,NR4A2,ODC1,Plekha6,PLK3,PPARGC1A,PPARGC1B,PPP1R3C,SDS,SEC22B,SLC25A25,TAT,TGFB1,TNS1 | 455 (17) |
| clofibrate | NA | chemical drug | Activated | 2.13e+00 | 0.0e+00 | Acot1,BAAT,CCND1,CCND2,CPT1A,CPT2,FAS,IGFBP1,IL1RN,LDLR,NR2C1,PCSK9,PEX11A | 501 (28) |
| pirinixic acid | NA | chemical toxicant | Activated | 2.12e+00 | 0.0e+00 | Acot1,ADIPOR2,ASL,ASNS,CCND1,CCNE1,Cd24a,CDKN1A,CIDEC,CPT1A,CPT2,CYP7A1,DLAT,DYNLL1,FAS,FASN,GADD45B,GOT1,HMGCS1,HNF4A,ID2,IL1RN,INSIG1,KLF11,LDLR,MBL2,NPC1,NR2C1,NRG4,PCSK9,PEX11A,PLIN4,PLIN5,POR,PPARGC1A,PXMP4,SERPINE1,SLC25A32,ST3GAL5,SYCP3,THRB,TIMM17A,WEE1 | 306 (19) |
| glucocorticoid | NA | chemical drug | Activated | 2.11e+00 | 0.0e+00 | AGT,BCL2L11,BCL3,CD79B,CDKN1A,CEBPB,CPT2,CYP7A1,DBP,FAS,FASN,FNDC3A,GOT1,IGFBP1,IL1RN,IL6R,LPIN1,NR3C1,NR4A2,ODC1,PAH,PER1,PER2,PPARGC1A,SERPINA7,SERPINE1,STC1,TAT,TDO2,TGFB1,TK1,TNFRSF11B | 468 (23) |
| EHMT1 | 1.00e-01 | transcription regulator | Activated | 2.11e+00 | 0.0e+00 | CDKN1A,EFNA1,GTF2IRD1,MEGF9,MSLN,PCSK6,PKP2,POR,PPL,RARRES1,SELENBP1,SLC8B1,TDRKH | NA |
| CEBPB | 7.00e-01 | transcription regulator | Activated | 2.11e+00 | 0.0e+00 | AGT,ARG1,ASNS,AURKA,BHMT,CCND1,CCND2,CCNE1,CD274,CDKN1A,CDT1,CEBPB,CHEK2,CIRBP,CPT1A,CSF3R,CTPS1,CYP17A1,DDB2,FAS,FGFR2,FZD1,GDF15,HNRNPD,IFIT3,IGFBP1,IL1RN,JUN,KPNA2,LAMC1,LDLR,LMNB1,LPIN1,LYN,MBL2,NCAPD2,NFKBIZ,NOP56,NUPR1,ODC1,PLA2G4A,PLXND1,PPARD,PPARGC1A,RAD18,SERPINE1,SESN2,SLC38A2,STAT3,TBRG4,TFRC,TGFB1,TK1,TMPO,UBE2F,UBR7,VCAN,WEE1,XBP1 | 507 (22) |
| aspirin | NA | chemical drug | Activated | 2.10e+00 | 1.0e-02 | CCND1,CDKN1A,CNTF,DLL4,EDNRB,EFNA1,GDF15,LAMA3,NOX4,NPC1,PLA2G4A,PPARD,PTGER3,SERPINB9,TGFB1 | NA |
| FOXO4 | -3.00e-01 | transcription regulator | Activated | 2.08e+00 | 0.0e+00 | BCL2L11,CCND1,CCND2,CDKN1A,DHCR24,EDNRB,FASN,FDFT1,GADD45B,HMGCS1,IGFBP1,MAP1LC3B,NRP2,SERPINE1,SOX5,TGFB1 | 428 (26) |
| EP300 | -5.00e-02 | transcription regulator | Activated | 2.08e+00 | 0.0e+00 | AGT,ALDOA,ARHGAP24,CA12,CCND1,CCNE1,CD274,CDKN1A,CHKA,CPT1A,CPT2,CYP7A1,DHRS3,Esrra,FASN,FOXO1,ID2,ID3,IL15RA,IRF6,ITGA9,JUN,LAMA3,MAF,NR3C1,PCYT1A,PFKFB3,PLA2G4A,PPARGC1A,PPFIBP2,PSAT1,RB1,REN,RNF157,RNF39,RSAD2,RTP4,SDC4,SPSB1,STOM,TK1,TNFAIP1,TNFAIP3,Tsc22d3,XBP1 | 462 (23) |
| triptolide | NA | chemical drug | Activated | 2.08e+00 | 7.0e-02 | BIRC2,CDKN1A,DLL4,EDNRB,EFNA1,FAS,GCLM,JUN,LAMA3,NFE2L2,SERPINB9 | NA |
| PRKAA | NA | group | Activated | 2.04e+00 | 1.0e-02 | CCND1,CDKN1A,CLDN1,CPT1A,FASN,FKBP5,PPARGC1A | NA |
| cyclic AMP | NA | chemical - endogenous mammalian | Activated | 2.02e+00 | 0.0e+00 | AFAP1L2,ARG1,ASS1,CCND1,CCND2,CDKN1A,CEBPB,CNTF,CREM,CYP17A1,DUOX2,GCK,GOT1,IGFBP1,IL15,IL1RN,IL33,INHBA,JUN,NR4A2,ODC1,PAH,PER1,PFKFB1,PLA2G4A,PPARGC1A,REN,SERPINE1,STAT3,TAT,TK1 | 455 (27) |
| myclobutanil | NA | chemical toxicant | Activated | 2.00e+00 | 0.0e+00 | Ces2/Ces2c,GSTM4,HAO2,Hsd3b4 (includes others),POR,SLC3A2,SQLE | NA |
| triadimefon | NA | chemical toxicant | Activated | 2.00e+00 | 1.0e-02 | Ces2/Ces2c,GSTM4,HAO2,Hsd3b4 (includes others),POR,SLC3A2,SQLE | NA |
| betamethasone | NA | chemical drug | Activated | 2.00e+00 | 2.0e-02 | ASPA,GCLM,HIF3A,NR3C1 | NA |
| CDH11 | -7.00e-01 | other | Activated | 2.00e+00 | 4.0e-02 | AGT,EGF,PIK3R1,TNK2 | NA |
| RUVBL1 | -1.90e-01 | transcription regulator | Activated | 2.00e+00 | 5.0e-02 | CCND2,GADD45B,KIFC2,NUCKS1,SESN2 | NA |
| pevonedistat | NA | chemical drug | Activated | 2.00e+00 | 7.0e-02 | ARG1,BCL2L11,CDT1,RHOB | NA |
| TLR7/8 | NA | group | Activated | 2.00e+00 | 1.1e-01 | NFKBIZ,RECQL4,RGS1,TNFAIP3 | NA |
| PF543 | NA | chemical drug | Activated | 2.00e+00 | 1.9e-01 | FGR,GDF15,TGFB1,TNFRSF11B | NA |
| propylthiouracil | NA | chemical drug | Activated | 2.00e+00 | 3.0e-01 | BTG2,C1QTNF3,CA1,CHKA,FMO3,GSTT2/GSTT2B,JUN,NNMT,NRN1,PKP2,RUSC2,SLC16A10 | NA |
| GSTO1 | -1.00e-01 | enzyme | Activated | 2.00e+00 | 3.3e-01 | DUSP6,NR4A2,PARP9,ZFP36L1 | NA |
| GNA12 | -3.00e-02 | enzyme | Activated | 2.00e+00 | 4.9e-01 | BAIAP2,GCLM,PIK3R1,SOS1 | NA |
| U0126 | NA | chemical drug | NA | 2.00e+00 | 0.0e+00 | AGT,ALPL,ATF3,BCL2L11,BHLHE40,BIRC3,BRAP,CCND1,CCND2,CCNE1,CD274,CDKN1A,CEBPB,CLCF1,CLDN2,CNTF,CTDP1,CXCL11,CYP7A1,DBP,DCHS1,DUSP6,EDNRB,EGF,ETV5,FASN,FGFR2,FKBP5,FMO3,GADD45B,GDF15,HERPUD1,IGFBP1,IHH,IL17RB,INHBA,IRF1,JUN,LDLR,NFE2L2,NR4A2,NREP,NRN1,PAWR,PER1,PER2,PLA2G4A,PLD1,PPARD,REN,RND3,SERPINE1,SIRPA,STAT3,STC1,SYK,TCF7L2,TNFRSF11B,TSC22D1,UBC | 394 (20) |
| AMBRA1 | 1.60e-01 | other | NA | 1.99e+00 | 1.6e-01 | CCND1,CCND2,CDKN1A,SERPINE1 | NA |
| guanidinopropionic acid | NA | chemical drug | NA | 1.99e+00 | 1.8e-01 | Esrra,PPARD,PPARGC1A,PPARGC1B | NA |
| ZBED6 | NA | transcription regulator | NA | 1.99e+00 | 6.0e-02 | DDIT4,GCK,MAP3K14,WWC1 | NA |
| brefeldin A | NA | chemical - endogenous non-mammalian | NA | 1.99e+00 | 2.6e-01 | ADRA1B,CEBPB,GADD45B,SESN2 | NA |
| lipofermata | NA | chemical reagent | NA | 1.98e+00 | 0.0e+00 | ATF3,CPT1A,CPT2,PPARGC1A,TGFB1,XBP1 | NA |
| gamma-tocotrienol | NA | chemical drug | NA | 1.98e+00 | 0.0e+00 | CCND1,JUN,NLRP3,TNFAIP3 | 361 (18) |
| MST1 | 4.50e-01 | growth factor | NA | 1.98e+00 | 3.0e-02 | CCND1,FAS,IL15,IL1RN | NA |
| apigenin | NA | chemical - endogenous non-mammalian | NA | 1.98e+00 | 1.9e-01 | CCND1,CCND2,CDKN1A,CREM,CYP17A1,GCLM | NA |
| Stat6 dimer | NA | complex | NA | 1.98e+00 | 8.0e-02 | ARG1,FAS,PPARD,PPARGC1A | NA |
| PALMD | -6.20e-01 | other | NA | 1.98e+00 | 3.0e-02 | ALPL,PFKFB3,PIK3R1,TNFAIP3 | NA |
| NOG | -3.00e-02 | growth factor | NA | 1.98e+00 | 2.2e-01 | FAS,ID3,ID4,VCAN | NA |
| phorbol 12,13-dibutyrate | NA | chemical - endogenous non-mammalian | NA | 1.98e+00 | 8.0e-02 | ALPL,CCND2,CDKN1A,SERPINE1 | NA |
| letrozole | NA | chemical drug | NA | 1.97e+00 | 5.0e-02 | CCND1,CDKN1A,CYP17A1,PPP1R9B | NA |
| SP3 | 1.50e-01 | transcription regulator | NA | 1.97e+00 | 4.0e-02 | ASNS,ATF3,CBS/LOC102724560,CCND1,CDKN1A,CYP17A1,CYP26A1,FAS,GDF15,JUN,LDLR,PCYT1A,PTPN1,SERPINE1,STAT3,TGM1 | NA |
| carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone | NA | chemical reagent | NA | 1.97e+00 | 0.0e+00 | ASNS,ITPR1,PPARGC1A,PPARGC1B | 364 (16) |
| CRTC1 | -2.00e-02 | transcription regulator | NA | 1.96e+00 | 2.0e-02 | IDH3A,NR4A2,PER1,PPARGC1A | NA |
| KAT6A | 0.00e+00 | enzyme | NA | 1.96e+00 | 4.7e-01 | CC2D2A,CDKN1A,HAND2,PKDCC | NA |
| hydrocortisone | NA | chemical - endogenous mammalian | NA | 1.96e+00 | 1.0e-02 | CCND1,CCND2,CCNE1,CEBPB,FAS,GADD45B,IGFBP1,INHBA,NR3C1,PLA2G4A,SERPINE1,TAT,TNFAIP3,TNFRSF11B | NA |
| Go 6976 | NA | chemical drug | NA | 1.96e+00 | 1.8e-01 | CCND1,CDKN1A,NR4A2,PLD1,STC1 | NA |
| ETV6-RUNX1 | NA | fusion gene/product | NA | 1.95e+00 | 0.0e+00 | ARHGAP24,AURKA,BCL3,DCHS1,DDIT4,DLL1,FTSJ3,GBP2,GNA15,ID2,IFIT3,IL15,IL15RA,IRF1,KLC4,LYN,MKNK2,Mx2,OAS2,PRMT2,PSMD9,RNF144A,RSAD2,STAT3,TCF7L2,TGFB1,TNFRSF14,TNK2,TRIM6-TRIM34 | 127 (6) |
| CRTC2 | 2.80e-01 | other | NA | 1.94e+00 | 0.0e+00 | BACH2,CCND1,Esrra,GOT1,IDH3A,PPARGC1A,SDS | 195 (7) |
| ESR2 | -2.00e-02 | ligand-dependent nuclear receptor | NA | 1.93e+00 | 0.0e+00 | ADAMTS1,ADCYAP1R1,AGT,ANKH,APEX1,ARL4A,ATF3,AURKA,BTG2,CA12,CBS/LOC102724560,CCND1,CCNE1,CDC14B,CDKN1A,CLDN1,CTPS1,CYP17A1,DDB2,DHCR24,ELL2,FAM110C,FASN,FKBP5,FOXA1,FOXO1,FSCN1,GADD45B,GBP2,GNL3,HAND2,HMGCS1,IFI44,IFIT3,INSIG1,KPNA2,LMNB1,LMO4,LSM2,LYN,MAF,MAP2K6,MBL2,MSLN,NCOA4,NFYA,NRP2,ODC1,PARP14,PPP1R3C,PSAT1,RRP12,RSAD2,S1PR1,SDC4,SEC24D,SERPINE1,SLC38A2,SOCS2,SOS1,STC1,TAT,TGFB1,TK1,TNFRSF11B,TP53INP1,TSC22D1,Tsc22d3,WEE1 | 488 (20) |
| RC3H1 | NA | enzyme | NA | 1.93e+00 | 0.0e+00 | CLDN1,IFI44,IFI44L,IFIT3,IRF1,MX1,OAS2,PARP9,RSAD2,TNFAIP3 | 311 (12) |
| MYOCD | -2.00e-01 | transcription regulator | NA | 1.93e+00 | 1.0e+00 | CDKN1A,HAND2,VCAN,XBP1 | NA |
| CD40 | -5.50e-01 | transmembrane receptor | NA | 1.92e+00 | 0.0e+00 | ASNS,ATP6V1B2,BCL2L11,BIRC3,CCND1,CCND2,CDKN1A,COX10,DUSP6,EDEM1,FAS,GNL3,IL15,IL15RA,IL1RN,IL6R,IRF1,JUN,KLF9,MAP3K14,MAP3K6,NDUFAF4,NOLC1,ODC1,RRP12,SERPINE1,SLC38A2,TBRG4,TNFAIP3,TNFRSF11B,WDR43,XBP1 | 377 (17) |
| HSPB8 | -2.20e-01 | kinase | NA | 1.91e+00 | 0.0e+00 | ALDOA,CPT1A,CPT2,LPIN1,MAP1LC3B,PFKFB2,PPARGC1A | NA |
| rolipram | NA | chemical drug | NA | 1.91e+00 | 1.0e-02 | BCL2L11,IL1RN,NLRP3,PPP2CA,PTPN1,PYCARD,TGFB1 | 398 (18) |
| PDCD1 | 1.00e-01 | transmembrane receptor | NA | 1.90e+00 | 0.0e+00 | CBLB,FAS,IL33,KPNA2,NLRP3,PRKD3,RAB30,SLC7A5,TGFB1,ZFP57 | 289 (19) |
| ZFTA-RELA | NA | fusion gene/product | NA | 1.89e+00 | 0.0e+00 | BCL3,BIRC3,IL15RA,IL1RN,IRF1,SDC4,TNFAIP3 | NA |
| diclofenac | NA | chemical drug | NA | 1.88e+00 | 0.0e+00 | ASNS,ATF3,BACH1,CCND1,CDKN1A,CEBPB,GDF15,HERPUD1,JUN,KLF9,MAP1LC3B,MID1IP1,PSAT1,SERPINE1,SLC38A2,SOS1 | 401 (26) |
| LEPR | -4.30e-01 | transmembrane receptor | NA | 1.87e+00 | 1.0e-02 | ATF3,CREB3L2,FASN,GADD45B,GADD45G,GCK,ID2,IL1RN,LDLR,PPARD,PPARGC1A,SERPINE1,SOCS2,STAT3,TCF7L2,TGFB1,TP53INP1 | 423 (25) |
| DCN | 9.00e-02 | other | NA | 1.86e+00 | 2.3e-01 | CDKN1A,S1PR1,SERPINE1,TGFB1 | NA |
| nelfinavir | NA | chemical drug | NA | 1.85e+00 | 0.0e+00 | ASNS,ATF3,HERPUD1,NNMT,NUPR1,PLIN4,PSAT1,SESN2,SLC1A4,TGM1,TNFRSF11B,XBP1 | NA |
| SIRT1 | 7.00e-02 | transcription regulator | NA | 1.85e+00 | 0.0e+00 | AGT,ARG1,BIRC3,CA12,CCND1,CCND2,CD79B,CDKN1A,CEBPB,CLEC10A,CMPK2,CPT1A,DBP,EDEM1,Esrra,FAS,FASN,FOXO1,GCK,GSTM4,HELZ2,Hsd3b4 (includes others),IFI44,Ifi47,IFIT3,Igtp,Irgm1,ITPKA,LDLR,MADD,MAF,NFE2L2,NMRK1,OAS2,Oasl2,PARP14,PER1,PPARGC1A,RNF39,RSAD2,RTP4,SDS,SERPINE1,SLC7A10,SSBP3,STAT3,TBC1D8,Wasl | 489 (22) |
| bucladesine | NA | chemical toxicant | NA | 1.84e+00 | 0.0e+00 | ACER2,ADAMTS1,ADGRL2,AGL,ASS1,CCND1,Cd24a,CDKN1A,CEBPB,CITED4,CLCF1,COQ10B,CPT1A,CREM,CYP17A1,CYP7A1,DUSP6,EPHA4,FOXO1,GADD45B,GCK,GDF15,ID4,IGFALS,IGFBP1,IRF1,JUN,LDLR,MAP3K5,NR4A2,ODC1,Rcan1,SERPINE1,STC1,STOM,TGFB1,TINAGL1,WNT4 | 447 (23) |
| pioglitazone | NA | chemical drug | NA | 1.83e+00 | 1.0e-02 | ADIPOR2,CCND1,CDKN1A,CYP17A1,CYP7A1,DFFB,IL1RN,LDLR,LPIN1,PDE3B,PPARD,PPARGC1A,PPARGC1B,RB1,SERPINE1,TGFB1,XBP1 | 434 (25) |
| resveratrol | NA | chemical drug | NA | 1.83e+00 | 0.0e+00 | ATF3,BIRC3,CCND1,CCND2,CCNE1,CDKN1A,CPT1A,CYP17A1,CYP7A1,DYNLL1,FAS,FASN,FOXA2,FOXO1,GCK,GDF15,HNF1A,IGFBP1,JUN,LDLR,NCOA4,NRIP1,PPARGC1A,PPP1R13B,SARM1,SERPINE1,SESN2,TFRC,TGFB1,TGM1,TNFRSF11B,TNS1,XBP1 | 535 (23) |
| ADIPOQ | -2.00e-02 | other | NA | 1.83e+00 | 0.0e+00 | ADIPOR2,ARG1,BCL3,CCND1,CDKN1A,CEBPB,CLEC10A,CXCL11,CYP7A1,FASN,FGFR2,FZD1,GCK,HNF4A,LDLR,NOX4,PFKFB1,PPARD,PPARGC1A,STAT3,TGFB1,TNFAIP3,WNT4 | 444 (25) |
| BCR (complex) | NA | complex | NA | 1.80e+00 | 0.0e+00 | ALDOA,ASNS,ATF3,ATP6V1B2,BCL2L11,BCL3,CCND1,CCND2,CDKN1A,CLCF1,COX10,FAS,FOXO1,GBP2,GNL3,KLF9,LGALS9B,MPHOSPH10,NDUFAF4,NOLC1,ODC1,PDE7A,PPFIBP2,RHOF,RRP12,S1PR1,SLC38A2,TBRG4,WDR43,XBP1,ZNF608 | 414 (23) |
| STK11 | -1.00e-01 | kinase | NA | 1.79e+00 | 0.0e+00 | ALDOA,ASS1,ATF3,BCL2L11,BCL6B,CCND1,CD274,CDKL3,CDKN1A,CSF3R,CTPS1,FGFR2,GADD45B,GART,IGFBP1,IL33,KLF12,LGALS9B,MAFK,NET1,NR4A2,NRCAM,PPARGC1A,PSAT1,RB1,REN,RGS1,SARDH,SERPINE1,SLC16A4,TNFAIP3 | 480 (24) |
| NUPR1 | 9.80e-01 | transcription regulator | NA | 1.79e+00 | 0.0e+00 | ABHD15,ABL2,ADCY9,ARHGEF26,ATF3,AURKA,CCNF,CEBPB,DHCR24,ELL2,ETV6,GBP2,GDF15,GNE,IL6R,IRF2BP2,KANK2,LMNB1,MAP1LC3B2,MCM10,MEGF9,MRS2,MTFMT,NAA40,NRBF2,NUCKS1,NUPR1,PARP9,PFKFB3,PIK3R1,PLEKHM3,PLK3,PPFIBP2,PRELID2,RAB11FIP5,RFX5,RUSC2,SERPINE1,SESN2,SHROOM3,SLC16A10,SLC16A6,SPATS2L,SPRTN,SRGAP2,ST6GALNAC6,TDRKH,TMPO,TNFAIP8L1,UNC5B,VANGL1,WDCP,XBP1,ZFAND2A,ZFP36L1 | NA |
| fingolimod | NA | chemical drug | NA | 1.78e+00 | 1.6e-01 | CD274,CDKN1A,FASN,S1PR1,SERPINE1,TGFB1 | NA |
| Lh | NA | complex | NA | 1.77e+00 | 0.0e+00 | ADAMTS1,ADCY9,ALPL,CARD10,CCND2,CYP17A1,DHRS3,FGFR2,FKBP5,GADD45B,GADD45G,ITPR1,JUN,LDLR,MAFB,MAP1LC3B,MAP3K5,MAPK6,MSMO1,PAWR,PER1,PIM3,PTP4A1,PTPN1,RGS7,RHOB,RPRM,RPS18,SLC1A4,THRB,TK1,TNFAIP3,TNFRSF11B | 498 (25) |
| IL10 | 8.00e-02 | cytokine | NA | 1.76e+00 | 0.0e+00 | ARG1,BCL2L11,BCL3,CA12,CCND2,Cd24a,CD274,CDKN1A,CSF3R,CXCL11,ELAVL1,FAS,FKBP5,Igtp,IL17RB,IL1RN,IL33,INHBA,IRF1,JUN,KLRD1,LYN,LZTS1,MAF,NCAPD2,NUP98,PTPN1,RARRES1,SLC7A5,STAT3,TFRC,TGFB1,TINAGL1,VCAN,WEE1 | 397 (20) |
| LY294002 | NA | chemical drug | NA | 1.76e+00 | 0.0e+00 | ADAMTS1,ADIPOR2,AGL,ATF3,ATP2B2,AURKA,BCL2L11,BHLHE40,BIRC3,BRAP,CCND1,CCND2,CCNE1,CD274,CDKN1A,CEBPB,CREM,CYP7A1,DHCR24,DUSP6,Esrra,FAS,FASN,FDFT1,FOXO1,GCK,GDF15,HDAC2,HERPUD1,HMGCS1,IL1RN,IL33,IRF1,JUN,LMO4,MAF,MEIS2,NFE2L2,NR4A2,NRN1,PIK3R1,PPARD,PTPN1,REN,RGS1,RND3,S1PR1,SERPINE1,SOCS2,SOS1,SQLE,SYK,TGFB1,TNFAIP3,VCAN,XBP1,ZNF184 | 433 (22) |
| nicotinamide-beta-riboside | NA | chemical - endogenous mammalian | NA | 1.76e+00 | 0.0e+00 | AKR1C4,ARG1,FMO3,HSD17B2,IDH3A,NLRP3,POR,PPARGC1A,RDH16 | NA |
| hydrogen peroxide | NA | chemical - endogenous mammalian | NA | 1.75e+00 | 0.0e+00 | AGT,APEX1,ATF3,AURKA,BANP,BCL2L11,BIRC3,BTG2,CCND1,CCNF,CDKN1A,CSF3R,DDIT4,ENC1,FAS,FASN,FDFT1,GADD45B,GCLM,GDF15,HDAC2,ID3,INSIG1,JUN,LDLR,MSMO1,NFE2L2,NUCKS1,ODC1,OSGIN1,PAH,PPARGC1A,PPARGC1B,SERPINE1,SQLE,STAT3,STC1,SUSD6,TFRC,TGFB1,TNFAIP3,TP53INP1,WDR26,WNT4,XBP1 | 477 (23) |
| KAT2B | -1.70e-01 | transcription regulator | NA | 1.75e+00 | 0.0e+00 | ALDOA,CDKN1A,EDEM1,FASN,FGR,NR2C1,PFKFB3,RB1 | 392 (20) |
| linoleic acid | NA | chemical - endogenous mammalian | NA | 1.75e+00 | 5.0e-02 | CPT1A,FASN,LDLR,PLIN4,PLIN5,PPARD,REN | NA |
| PTP4A1 | 1.33e+00 | phosphatase | NA | 1.74e+00 | 2.0e-02 | ALDOA,ELAVL1,FASN,GMPS,HNF4A,MAP3K5,NOP56,PIK3R1,PPP2CA,SOS1,VCAN | NA |
| fenofibrate | NA | chemical drug | NA | 1.74e+00 | 0.0e+00 | Acot1,ADIPOR2,APEX1,ASNS,BCL2L11,CCND1,CEBPB,CPT1A,CPT2,CYP17A1,CYP7A1,DLAT,FABP7,FASN,GOT1,ID2,JUN,LDLR,NR3C1,PNPLA2,POR,PPARGC1A,SERPINE1,STAT3,TGFB1,THRB,TIMM17A,TP53INP1 | 395 (18) |
| RIPK1 | -1.00e-01 | kinase | NA | 1.73e+00 | 2.0e-02 | ARG1,ASNS,ASS1,GOT1,IL33,MAP3K14,TNFAIP3 | NA |
| HNF1B | -9.00e-02 | transcription regulator | NA | 1.73e+00 | 0.0e+00 | AKR1C4,BHLHE40,CLDN1,EXT1,FOXA2,FZD1,HNF1A,HNF4A,ID3,ID4,IGFBP1,IHH,MAFB,ONECUT1,PCSK9,SGK2,SLC26A3 | 358 (11) |
| FOXO1 | 1.79e+00 | transcription regulator | NA | 1.72e+00 | 0.0e+00 | AGT,AGXT,BACH2,BCL2L11,BIRC3,CCND1,CCNF,CD79B,CDKN1A,COX10,CPT1A,CPT2,CYP7A1,DDIT4,EDNRB,EFHD1,FAS,FASN,FOXA2,FOXO1,GADD45B,GCK,IGFBP1,IL15,JUN,MAP1LC3B,MRPL47,NDUFAF4,NPC1,NRP2,PIK3IP1,PNPLA2,PPARGC1A,PPARGC1B,Rcan1,S1PR1,SERPINE1,SLC25A15,SLC25A22,SLC25A25,SLC25A30,SOX5,SQLE,TAT,TDO2,TGFB1,TOMM40,UBASH3B,WNT4 | 466 (26) |
| CDK2 | 1.60e-01 | kinase | NA | 1.72e+00 | 0.0e+00 | BCL2L11,CCNE1,CDKN1A,GCK,PCYT1A,RB1,TNFAIP3 | 305 (18) |
| Fgf | NA | group | NA | 1.72e+00 | 2.0e-02 | CCND1,GNL3,JUN,ODC1,PER1 | NA |
| AICAR | NA | chemical - endogenous mammalian | NA | 1.71e+00 | 0.0e+00 | ARG1,CCND1,CCNE1,CDKN1A,CEBPB,FASN,FOXO1,PNPLA2,PPARD,PPARGC1A,SERPINE1,SESN2,TGFB1 | 469 (24) |
| F2 | -4.00e-02 | peptidase | NA | 1.71e+00 | 0.0e+00 | BCL3,BIRC2,BIRC3,CCND1,CCND2,CDKN1A,CITED4,CTPS1,DIO3,EDNRB,ELL2,EPB41,HIVEP1,IL15RA,JUN,MAP3K5,MTSS1,PLA2G4A,PPIF,RGS3,RHOB,SDC4,SERPINE1,TNFAIP3,TOMM40 | 395 (21) |
| entinostat | NA | chemical drug | NA | 1.71e+00 | 3.0e-02 | BCL2L11,CCND1,CCNE1,CDKN1A,NFE2L2,RB1,SERPINE1,XBP1 | NA |
| Notch | NA | group | NA | 1.70e+00 | 0.0e+00 | AGT,CD300LF,CDKN1A,CLEC10A,CSF3R,DLL4,GADD45B,ID2,ID3,IL17RB,MEX3B,NET1,PATZ1,PIK3IP1,SRFBP1,TGM1 | 312 (14) |
| clopidogrel | NA | chemical drug | NA | 1.68e+00 | 0.0e+00 | ASNS,ATF3,ATOH8,C11orf86,DHRS3,HERPUD1,IFRD1,KLF15,NUPR1,PSAT1,RASL11A,SESN2,SLC1A4,SLC3A2,XBP1 | NA |
| NFAT5 | -2.70e-01 | transcription regulator | NA | 1.66e+00 | 0.0e+00 | CHEK2,DDIT4,IFIT3,IL1RN,IL6R,IRF1,Irgm1,LAMA3,Mx2,NOX4,Oas1b,POLA1,PPARD,RSAD2,SLC7A2,TNFAIP3,TNFRSF11B | 352 (22) |
| vorinostat | NA | chemical drug | NA | 1.65e+00 | 0.0e+00 | ACKR4,ADAMTS1,ALPL,AURKA,B3GALT1,BCL2L11,BIRC2,BIRC3,CCND1,CCND2,CD79B,CDKN1A,CHKA,CISH,CLDN2,ELAVL1,FAS,HDAC2,HMGCS1,IRF1,JUN,LDLR,PLIN4,RB1,ST3GAL5 | 376 (18) |
| PNPLA2 | 2.09e+00 | enzyme | NA | 1.64e+00 | 0.0e+00 | ACO2,Acot1,ARG1,CPT1A,CPT2,FASN,PLIN5,PNPLA2,PPARGC1A,PPARGC1B,TGFB1 | 414 (22) |
| cholesterol | NA | chemical - endogenous mammalian | NA | 1.64e+00 | 0.0e+00 | Acot1,AGT,ARG1,ATF3,CPT1A,CYP7A1,FASN,FDFT1,HMGCS1,HNRNPD,IHH,IL1RN,INHBA,INSIG1,KLF11,LDLR,MAP1LC3B,MSMO1,NR4A2,PCSK9,PPARD,PPARGC1A,PPARGC1B,PSAT1,SLC7A5,SQLE,TGFB1,XBP1 | 266 (16) |
| UHRF2 | 3.80e-01 | enzyme | NA | 1.63e+00 | 0.0e+00 | ADIPOR2,BCL2L11,CCNE1,FOXO1,PPP1R13B,ZNF672 | NA |
| fluocinolone acetonide | NA | chemical drug | NA | 1.63e+00 | 1.0e-02 | ACKR4,FKBP5,IL33,KLF15,TAT,UBR7,WNT4 | NA |
| VitaminD3-VDR-RXR | NA | complex | NA | 1.63e+00 | 2.0e-02 | CDKN1A,FOXO1,HSD17B2,IGFBP1,PPARD,TRPV6 | NA |
| ziritaxestat | NA | chemical drug | NA | 1.63e+00 | 3.0e-02 | CEMIP,DDIT4,GBP2,IFIT3,MX1,OAS2 | NA |
| trans-hydroxytamoxifen | NA | chemical drug | NA | 1.61e+00 | 0.0e+00 | ADCY9,ARHGAP24,BRPF1,DDIT4,EFNA1,ENC1,GNE,INSIG2,IRF6,MYO1B,PPP1R3C,PTGER3,RAB30,RND3,S1PR1,SELENBP1,SERPINB9,STC1,UNC5B,XBP1 | 318 (7) |
| PRKCD | -9.00e-02 | kinase | NA | 1.60e+00 | 0.0e+00 | BIRC2,BIRC3,CCND1,CCNE1,CDKN1A,CEBPB,CEMIP,DUSP6,FZD1,GDF15,IL1RN,JUN,LDLR,LYST,MAP1LC3B,MSI1,NOCT,ODC1,PALMD,SERPINE1,SETBP1,STAT3,TNFRSF11B | 353 (19) |
| deferoxamine | NA | chemical drug | NA | 1.59e+00 | 0.0e+00 | ALDOA,BACH1,BHLHE40,CACNB4,CCND1,CCND2,CCNE1,CDKN1A,CYTH1,FASN,GADD45B,GDF15,JUN,LAMA3,MAP1LC3B,NCOA4,NR4A2,PFKFB1,PFKFB3,PLA2G4A,RB1,RGS1,RSAD2,SERPINB8,SERPINE1,TFRC,TGFB1,TSC22D1,UBE2D1 | 391 (21) |
| SPRY2 | -1.20e-01 | other | NA | 1.59e+00 | 1.0e-02 | ARG1,CDKN1A,DUSP6,ETV5,FABP7,ID2,IL33,LMO4,PFKFB3,PTPN1,SDCCAG8 | NA |
| SOCS1 | 3.70e-01 | other | NA | 1.59e+00 | 0.0e+00 | ARG1,CCND1,CCND2,CCNE1,CD274,CDKN1A,CISH,FAS,FKBP5,IFI44,Ifi47,IFIT3,IL15,IRF1,JUN,MAP3K5,MX1,Mx2,Oas1b,OAS2,Oasl2,RB1,RSAD2,STAT3 | 346 (18) |
| MAPK8 | 1.70e-01 | kinase | NA | 1.57e+00 | 0.0e+00 | BAAT,BCL2L11,BIRC3,CCND1,CDKN1A,CEBPB,CYP7A1,DUSP6,EGF,FOXO1,GCK,HMGCS1,JUN,MAP3K9,NOX4,PPARD,PPARGC1A,PPARGC1B,SESN2,TNFAIP3,WNT4 | 454 (23) |
| mir-142 | NA | microRNA | NA | 1.57e+00 | 1.0e-02 | ADCY9,FNDC3A,GBP2,IL21R,IRF1,PTPN1,TSC22D1,Wasl | NA |
| ZC3H12A | 8.00e-01 | enzyme | NA | 1.56e+00 | 1.0e-02 | B4GALNT1,BCL3,CEBPB,CLCF1,IL21R,IL33,MAF,NFKBIZ,P2RY10,PDE7A,PEAK1,PPFIBP2,RHOF,TGFB1,ZFP36L1,ZNF608 | NA |
| resolvin D1 | NA | chemical - endogenous mammalian | NA | 1.56e+00 | 1.0e-02 | ARG1,CCND1,GBP2,IL33,JUN,TGFB1 | NA |
| ATF4 | -1.60e-01 | transcription regulator | NA | 1.56e+00 | 0.0e+00 | APEX1,ARHGAP24,ASNS,ATF3,CDKN1A,CEBPB,CPT1A,CYP7A1,DDIT4,FASN,GDF15,GYS1,HERPUD1,HNF4A,IHH,JUN,KLF9,MAP1LC3B,MID1IP1,NOX4,NUPR1,PSAT1,SESN2,SFXN5,SH3BP2,SLC1A4,SLC38A2,SLC3A2,SLC7A5,STAT3,TNFRSF11B | 399 (21) |
| pidnarulex | NA | chemical drug | NA | 1.55e+00 | 0.0e+00 | ASS1,BTG2,CDKN1A,CEMIP,DDB2,FABP7,FAS,GSTT2/GSTT2B,INHBA,MAP1LC3B,SESN2 | 270 (7) |
| norepinephrine | NA | chemical - endogenous mammalian | NA | 1.55e+00 | 1.0e-02 | ADRA1B,Cd24a,CEBPB,CITED4,COQ10B,CREM,GDF15,PER1,PPARGC1A,Rcan1,SERPINE1,TFRC,TGFB1,TINAGL1,USH2A | NA |
| diphenyleneiodonium | NA | chemical reagent | NA | 1.54e+00 | 1.0e-02 | AGT,ATF3,GDF15,NFE2L2,NLRP3,NOX4,PYCARD,SERPINE1,TGFB1 | 500 (24) |
| TGFB1I1 | 6.00e-02 | transcription regulator | NA | 1.54e+00 | 2.0e-02 | CDKN1A,NOX4,SERPINE1,TNS1 | NA |
| LMNA | -7.00e-02 | other | NA | 1.54e+00 | 1.0e-02 | ACKR4,ALPL,AMMECR1L,CERS6,FOXA2,GSTT2/GSTT2B,HIVEP1,ID3,IFI44,IRF1,Irgm1,JUN,KLF15,LMNB1,NPC1,PNPLA2,PPARGC1A,PPARGC1B,RB1,SLC38A2,TGFB1,TMPO,TOMM20 | 402 (26) |
| HDAC5 | -5.00e-01 | transcription regulator | NA | 1.52e+00 | 4.0e-02 | AURKA,CDKN1A,CPT1A,CPT2,ETNPPL,IGFBP1,JUN,PPARGC1A | NA |
| JQ1 | NA | chemical reagent | NA | 1.52e+00 | 0.0e+00 | BCL2L11,BIRC3,CCND1,CD274,CISH,CLEC10A,DHCR24,FDFT1,GADD45G,MAP1LC3B,MAP2K6,MAPK11,MX1,Oasl2,STAT3,TNFAIP3,TNFRSF14 | 425 (21) |
| FOXP3 | -6.40e-01 | transcription regulator | NA | 1.51e+00 | 0.0e+00 | BCL2L11,CD101,CDKN1A,DDB2,DUSP6,GBP2,ID2,IL6R,JUN,MAF,NRN1,P2RY10,PCYT1A,PDE3B,POLD3,RGS1,SDC4,SOCS2,TGFB1,TNFAIP3,XBP1 | 410 (21) |
| GW501516 | NA | chemical drug | NA | 1.51e+00 | 1.0e-02 | Acot1,CCND1,CDKN1A,CHKA,CPT1A,FASN,IGFBP1,LPIN1,PPARD,PPARGC1A,PPL | 402 (19) |
| SN-011 | NA | chemical reagent | NA | 1.51e+00 | 0.0e+00 | CD274,CDKN1A,DTX3L,IFI44,IFIT3,IRF1,LGALS9B,OAS2,RSAD2,RTP4,TNFAIP3 | NA |
| KLF11 | 7.30e-01 | transcription regulator | NA | 1.50e+00 | 4.0e-02 | ADAMTS1,AGT,CEBPB,CHRNA2,CPT2,EGF,IDH3A,PLA2G4A,PPARGC1A,SERPINE1,TGFB1 | NA |
| fenretinide | NA | chemical drug | NA | 1.50e+00 | 3.0e-02 | ACER2,ATF3,BIRC2,CCND1,HDAC2,JUN,MAPK6,NFE2L2 | NA |
| SETDB1 | -1.80e-01 | enzyme | NA | 1.47e+00 | 1.0e-02 | CBLB,ID2,IFI44,IFI44L,IL15,NFE2L2,STAT3 | 201 (7) |
| ARNT | 2.20e-01 | transcription regulator | NA | 1.47e+00 | 0.0e+00 | ACER2,ALDOA,BHLHE40,CARD10,CCND2,CD274,CEBPB,CLDN1,GADD45B,GDF15,HNF1A,HNF4A,ID2,MAFB,NR3C1,S1PR1,SERPINE1,SOCS2,STC1,TDO2,TFRC | 421 (20) |
| IL4 | NA | cytokine | NA | 1.46e+00 | 0.0e+00 | ARG1,ASS1,B4GALNT1,BCL3,BHLHE40,BIRC2,CCDC86,CCND1,CCND2,CCNE1,Cd24a,CD274,CD300LF,CD79B,CDKN1A,CEBPB,CHST3,CISH,CLDN2,CLEC10A,CMPK2,CNTF,CSF3R,CXCL11,CYTH1,DDIT4,DENND4A,DUOX2,Esrra,EXT1,FAS,FASN,FKBP5,FNIP2,FOXA1,FOXA2,FSCN1,GADD45B,GADD45G,GBP2,GNA14,GNA15,GNPNAT1,GSTT2/GSTT2B,ID3,IFI44,IFI44L,IFIT3,Igtp,IL15,IL15RA,IL17RB,IL1RL2,IL1RN,IL33,IRF1,Irgm1,JUN,KCNH1,KLRD1,LGALSL,MAF,MAFB,MAP3K5,MAPKAPK3,MFSD2A,NFKBIZ,NOCT,NR3C1,OAS2,ODC1,PAWR,PIK3R1,PLD1,POLA1,PPARGC1A,PPARGC1B,PSTPIP1,PTPN1,RAB30,RASGEF1B,RIPK3,Serpinb6b,SERPINB8,SERPINB9,SERPINE1,SGTB,SH3BP2,SIRPA,SLC25A25,SLC7A2,SLC7A5,SOCS2,SPATA2,Srrm1,SYK,TFRC,TGFB1,TINAGL1,TNFAIP3,TNFAIP8L1,TNFRSF11B,TNFRSF14,TUBA3E,USP2,XBP1,ZC3H12A,ZNF608 | 410 (18) |
| IL10RA | -1.00e-01 | transmembrane receptor | NA | 1.45e+00 | 0.0e+00 | ADGRL2,ANKH,ASS1,CBS/LOC102724560,Cd24a,CD300LF,CSF3R,DDIT4,EDNRB,EGF,FAS,GBP2,GNE,H2-T22,HAO2,Ifi47,IL15RA,IL1RN,INHBA,IRF1,Irgm1,LMO4,PPARGC1A,RIPK3,RSAD2,S1PR1,SECTM1,SELENBP1,Serpinb6b,SERPINB9,ST3GAL6,STAT3,TGFB1,TNFRSF14 | 261 (15) |
| USP8 | -4.20e-01 | peptidase | NA | 1.45e+00 | 1.0e-02 | CD274,HNRNPD,IFIT3,Irgm1,Oas1b,OAS2,Oasl2,SHANK3 | NA |
| IRF4 | -2.30e-01 | transcription regulator | NA | 1.44e+00 | 0.0e+00 | ALPL,ARG1,BIRC3,CDC14A,CXCL11,ELL2,GPRIN3,IL15RA,IL1RN,IL33,IRF1,IRF2BP2,LYST,RGS1,RHOB,TK1,XBP1,ZFP36L1 | 304 (14) |
| dihydrotestosterone | NA | chemical - endogenous mammalian | NA | 1.43e+00 | 0.0e+00 | ACO2,ADAMTS1,ADIPOR2,AGT,ALDOA,AMD1,ARG1,BTG2,CCND1,CCND2,CCNE1,CDKN1A,CPT1A,CREB3L2,CYP17A1,DHCR24,DYNLL1,EFNA1,EGF,ELAVL1,FASN,FKBP5,FOXA2,FOXO1,HACL1,HNF1A,ID2,IL17RB,IL6R,JUN,KLF15,LDLR,MAF,MAP2K6,MCM10,NR3C1,ODC1,PER1,PER2,PREP,RB1,REN,RHOB,RNF6,SELENBP1,SLC16A6,SLC19A2,SLC1A4,SLC2A9,SLC3A2,SQLE,SRGAP2,STBD1,UGDH,VCAN,WEE1,WNT4 | 489 (19) |
| NGLY1 | 1.50e-01 | enzyme | NA | 1.43e+00 | 2.0e-02 | IFI44,IFI44L,IFIT3,NFE2L2,RSAD2 | NA |
| Hif1 | NA | complex | NA | 1.43e+00 | 2.0e-02 | ADRA1B,ALDOA,CDKN1A,DDIT4,HIF3A,LPIN1,SERPINE1,TFRC | NA |
| EIF2AK3 | -1.70e-01 | kinase | NA | 1.42e+00 | 0.0e+00 | ASNS,ATF3,BCL2L11,BIRC2,BIRC3,BTG2,CCND1,CD274,CEBPB,EDEM1,HERPUD1,JUN,LMO4,MAP1LC3B,NUPR1,SEC22B,SEC24D,SLC1A4,XBP1 | 407 (24) |
| SB203580 | NA | chemical drug | NA | 1.42e+00 | 0.0e+00 | AGT,ALPL,ARG1,ATF3,BCL2L11,CCND1,CCNE1,Cd24a,CD274,CDKN1A,CEBPB,CHEK2,CLDN1,CNTF,COBL,CXCL11,DCHS1,DUOX2,EDNRB,EFNA1,EGF,FAS,FDFT1,FOXO1,GBP2,IFIT3,IL1RN,IRF1,JUN,MAP2K6,MAPK6,MORC4,MX1,NOX4,P4HA1,PALLD,PPARD,PPARGC1A,PPARGC1B,PRRG4,RBM3,RGS7,SECTM1,Serpinb6b,SERPINB9,SERPINE1,TAT,TGFB1,TGM1,TNFRSF11B | 409 (19) |
| 8-chlorophenylthio-adenosine 3’,5’-cyclic monophosphate | NA | chemical reagent | NA | 1.42e+00 | 0.0e+00 | BCL2L11,BIRC3,CDKN1A,CEBPB,CREM,HSD17B2,IGFBP1,LPIN1,PPARGC1A | 410 (25) |
| trichostatin A | NA | chemical drug | NA | 1.41e+00 | 0.0e+00 | ABHD5,ADAMTS1,ADGRL2,AGT,ALPL,ALS2,AMACR,ARG1,BAIAP2,BCL2L11,CA12,CCND1,CCND2,CD79B,CDKN1A,CEBPB,CGREF1,CISH,CLDN1,CREM,CSF3R,CTPS1,CYP26A1,DHRS3,DOK2,FAS,FASN,FOXA1,FOXO1,GADD45G,GCLM,GSTM4,HDAC2,HMGCS1,HNRNPD,ID2,ID3,IGFBP1,IRF1,LAMA3,LDLR,LIMA1,LMNB1,MAF,MAP1LC3B,MAT1A,MSI1,MYO1B,NFE2L2,NIFK,NPC1,NR4A2,NUCKS1,PAH,PCDH20,PCYT1A,PINX1,PNPLA2,PPARGC1B,PSAT1,RAC3,RASSF3,RECQL4,RHOB,RND3,SERPINE1,SGPL1,STAT3,TAT,TCF7L2,TGFB1,TGM1,TK1,TMPO,TNFRSF11B,UGDH,UNC5C,VCAN,WDR77,XBP1 | 424 (21) |
| gentamicin C | NA | chemical drug | NA | 1.41e+00 | 1.0e-02 | ADAMTS1,ASNS,BIRC3,Ctla2a,GTPBP4,IGFBP1,RBM3,SLC34A2 | NA |
| 15-deoxy-delta-12,14 -PGJ 2 | NA | chemical - endogenous mammalian | NA | 1.41e+00 | 1.0e-02 | BIRC2,BIRC3,CCND1,CCND2,CCNG1,CDKN1A,CXCL11,GCLM,GDF15,IRF1,JUN,MAP1LC3B,NFE2L2,NOX4,P4HA1,PLA2G4A,SERPINE1,SYCP3,TAT | NA |
| AXIN1 | NA | other | NA | 1.41e+00 | 0.0e+00 | CCND1,CCND2,CD274,ENC1,TCF7L2 | 369 (22) |
| GPS2 | 1.40e-01 | transcription regulator | NA | 1.41e+00 | 0.0e+00 | ADIPOR2,CCND1,CDKN1A,CYP7A1,DHRS3,FOXO1,FZD1,RHOB,RNF144B,TBC1D2,ZNF703 | 421 (22) |
| PTEN | -4.00e-02 | phosphatase | NA | 1.40e+00 | 0.0e+00 | ACO2,ARG1,ATF3,AURKA,BCL2L11,BCL3,BRPF1,BTG2,CA12,CCND1,CCNE1,CD274,CDKN1A,CEBPB,CLDN1,CRCP,CXCL11,DLAT,DLL4,EGF,Esrra,FAS,FASN,FDFT1,FGFR2,FOXA2,FOXO1,GART,GPR146,GPR157,GYS1,HMGCS1,ID4,IDH3A,IFRD1,JUN,LAMA3,LDLR,MAFK,MAPKAPK3,NFE2L2,NR3C1,NR4A2,PFKFB3,PIK3R1,PPARGC1A,PPP2R2B,PRMT2,RAB30,RAD51D,RB1,SDC4,SEPHS2,SERPINE1,SMOX,SQLE,STAT3,STOM,SYK,TGFB1,TNFAIP1,TNFRSF11B,TNFRSF14,WNT4 | 470 (23) |
| triamterene | NA | chemical drug | NA | 1.40e+00 | 1.0e-02 | ADAMTS1,ASNS,BIRC3,Ctla2a,GTPBP4,IGFBP1,RBM3,SLC34A2 | NA |
| MEOX2 | -9.40e-01 | transcription regulator | NA | 1.40e+00 | 3.0e-02 | CDKN1A,EFNA1,ID3,ID4,TNFAIP3 | NA |
| HOXA5 | -3.50e-01 | transcription regulator | NA | 1.39e+00 | 0.0e+00 | BIRC3,CDKN1A,CLDN1,GADD45B,IGFBP1,IHH,TGFB1 | NA |
| TAB1 | 8.00e-02 | enzyme | NA | 1.39e+00 | 2.0e-02 | BIRC3,CDKN1A,GBP2,JUN,SERPINE1 | NA |
| CHKB | 2.80e-01 | kinase | NA | 1.39e+00 | 2.0e-02 | CHKA,CPT2,FABP7,PPARD,PPARGC1A,PPARGC1B | NA |
| SCARB1 | 1.10e-01 | transporter | NA | 1.39e+00 | 2.0e-02 | DDIT4,FASN,FOXO1,IL1RN,LDLR,NLRP3 | NA |
| mir-21 | NA | microRNA | NA | 1.38e+00 | 0.0e+00 | BTG2,CD180,CD274,CDKN1A,CSF3R,DBP,EIF4E3,FAS,GBP2,Ifi47,IL6R,IRF1,Irgm1,NCAPD2,NIFK,NLRP3,NUCKS1,OAS2,PER2,PRRG4,RHOB,SIRPA,SLC16A10,SOX5,STAT3,TGFB1,TGM1,VRK1 | 363 (19) |
| S-adenosylmethionine | NA | chemical - endogenous mammalian | NA | 1.38e+00 | 1.0e-02 | FASN,GCLM,MAF,MAT1A,PPARGC1A,TGFB1 | NA |
| KL | -4.40e-01 | enzyme | NA | 1.37e+00 | 1.0e-02 | ATF3,CCND1,CDKN1A,IHH,SLC34A2,TGFB1,TNFRSF11B,XBP1 | 294 (19) |
| PPARG | -4.20e-01 | ligand-dependent nuclear receptor | NA | 1.36e+00 | 0.0e+00 | ADIPOR2,AGT,ARG1,CCND1,CD274,CDKN1A,CEBPB,CERS3,CIDEC,CPT1A,CPT2,CRAT,CTPS1,CYP26A1,DHRS3,DLAT,FASN,FOXA2,FZD1,GCK,GDF15,IGFBP1,IHH,IL33,INSIG1,INSIG2,JUN,KLF11,LDLR,MKNK2,NFE2L2,NOX4,ODC1,PDE3B,PEX11A,PEX6,PFKFB3,PLIN4,PLIN5,PPARD,PPARGC1A,PPARGC1B,PPP2R2B,Ppp2r3d,PTGER3,REN,RHOB,RNF144B,SERPINE1,TBC1D2,VSIR,ZNF703 | 448 (22) |
| phenylbutazone | NA | chemical drug | NA | 1.35e+00 | 1.0e-02 | ADAMTS1,ASNS,CCND1,Ctla2a,GTPBP4,IGFBP1,RBM3,SLC34A2 | NA |
| fenamic acid | NA | chemical reagent | NA | 1.35e+00 | 1.0e-02 | ADAMTS1,ASNS,BIRC3,Ctla2a,GTPBP4,IGFBP1,RBM3,SLC34A2 | NA |
| carbamazepine | NA | chemical drug | NA | 1.34e+00 | 0.0e+00 | ASNS,ATF3,BACH1,CEBPB,GDF15,HDAC2,HERPUD1,KLF9,MAP1LC3B,MID1IP1,PSAT1,SOS1,STAT3 | 302 (12) |
| indirubin | NA | chemical drug | NA | 1.34e+00 | 0.0e+00 | BIRC2,BIRC3,CCND1,IGFBP1,JUN | 386 (16) |
| RACK1 | -8.00e-02 | enzyme | NA | 1.34e+00 | 0.0e+00 | ADCYAP1R1,CDKN1A,IFI44,IFIT3,RB1,RSAD2 | 407 (24) |
| RNF138 | -1.40e-01 | enzyme | NA | 1.34e+00 | 0.0e+00 | BIRC3,CCND2,GADD45B,PLK3,SPECC1 | NA |
| IMMT | 3.10e-01 | other | NA | 1.34e+00 | 3.0e-02 | IL15,INHBA,MX1,OAS2,SERPINE1 | NA |
| EFNA3 | -2.00e-02 | kinase | NA | 1.34e+00 | 4.0e-02 | DUSP6,ETV5,FOXA2,IRF1,TGM1 | NA |
| STAT3 | 8.80e-01 | transcription regulator | NA | 1.33e+00 | 0.0e+00 | AGT,ALPL,APEX1,ARG1,ATP10A,BCL2L11,BCL3,CCND1,CCND2,CCNE1,CD274,CDKN1A,CEBPB,CMPK2,COBL,CYP26A1,DDIT4,DIO3,DLL1,FAS,FASN,FSCN1,FZD1,GADD45G,GBP2,HNF4A,HNRNPD,ID2,IFI44,IFIT3,IGFBP1,Igtp,IHH,IL1RN,IL33,IL6R,IRF1,Irgm1,LRP2,MAF,MAFB,MX1,Mx2,NFKBIZ,NOX4,NR4A2,NRP2,OAS2,OSCAR,PCSK9,PLA2G4A,PPARGC1A,REN,ROR1,RSAD2,S1PR1,SDC4,Serpinb6b,SERPINB9,SERPINE1,SOCS2,SOX6,STAT3,STC1,TGFB1,TNS1,VCAN,XBP1 | 431 (19) |
| ATF6 | 1.70e-01 | transcription regulator | NA | 1.33e+00 | 3.0e-02 | AURKA,CEBPB,CHKA,CPT1A,CPT2,MAP1LC3B,XBP1 | NA |
| FOXP1 | NA | transcription regulator | NA | 1.33e+00 | 4.0e-02 | CD274,CDKN1A,JUN,S1PR2,XBP1 | NA |
| HAVCR1 | NA | other | NA | 1.33e+00 | 0.0e+00 | CEBPB,CEMIP,CHKA,CTPS1,FSCN1,IL6R,IRF1,JUN,LMO4,LYN,NR3C1,NUCKS1,ODC1,PFKFB3,RB1,SESN2,SLC16A4,STAT3 | 205 (8) |
| ATM | -1.60e-01 | kinase | NA | 1.31e+00 | 0.0e+00 | BIRC2,CCND1,CDKN1A,CHEK2,FAS,GADD45B,GADD45G,IL33,IRF1,JUN,LPIN1,SERPINE1,TNFAIP3 | 387 (18) |
| TFE3 | 0.00e+00 | transcription regulator | NA | 1.31e+00 | 1.0e-02 | CCNE1,FASN,GCK,INSIG1,PNPLA2,PPARGC1A,PPARGC1B,SERPINE1 | 368 (16) |
| UCP1 | -1.10e-01 | transporter | NA | 1.31e+00 | 0.0e+00 | AMD1,ASNS,Cd24a,DBT,FASN,GDF15,GOT1,GREM2,IFIT3,ITPR1,MTHFD1,NUPR1,ODC1,PSAT1,SERPINE1,SLC3A2,SMOX,SMTNL2,STBD1,TGFB1,TPPP,UBC | 287 (7) |
| mevalonic acid | NA | chemical - endogenous mammalian | NA | 1.31e+00 | 3.0e-02 | FASN,LDLR,PCSK9,SERPINE1,TGFB1 | NA |
| GPR174 | -2.70e-01 | G-protein coupled receptor | NA | 1.29e+00 | 0.0e+00 | BCL2L11,BCL3,CBLB,CD180,CDT1,CHST3,CREM,CYTH1,CYTIP,DENND4A,GOT1,LAMC1,P2RY10,PDE3B,STAT3 | NA |
| mifepristone | NA | chemical drug | NA | 1.28e+00 | 0.0e+00 | Acot1,AKR1C4,ALPL,ARG1,ATF3,CCND1,Cd24a,CD274,CDKN1A,CEBPB,CISH,CLDN3,DDIT4,EDNRB,FAS,FDFT1,FKBP5,FOXA1,FOXA2,JUN,KLF11,KLF9,LDLR,NFE2L2,NOX4,NR3C1,PFKFB3,PLA2G4A,REM1,RHOB,SERPINE1,SLCO1B3,TAT,TENM3,TGFB1,TK1,VCAN,XBP1 | 456 (21) |
| hexarelin | NA | chemical toxicant | NA | 1.28e+00 | 0.0e+00 | FASN,INSIG1,INSIG2,PNPLA2,PPARGC1A | 327 (17) |
| NR3C2 | -3.80e-01 | ligand-dependent nuclear receptor | NA | 1.27e+00 | 0.0e+00 | ADAMTS1,AGT,ARG1,ATP1B1,Cmya5,DDIT4,FKBP5,INHBA,KLF9,LYST,NOX4,NR3C1,NR4A2,PLIN4,SERPINE1,TGFB1,TSPYL4 | 487 (24) |
| prexasertib | NA | chemical drug | NA | 1.26e+00 | 0.0e+00 | ATF3,BCL3,BIRC3,BTG2,CDKN1A,GADD45B,GDF15,IFIT3,SERPINE1,TNFAIP3 | 431 (20) |
| HNF4A | 6.70e-01 | transcription regulator | NA | 1.25e+00 | 0.0e+00 | AASS,Acnat1/Acnat2,ACO2,Acot1,AGT,AKR1C4,ALS2,AMACR,ARG1,ARHGEF19,ASB7,ASNS,ATP10A,BAAT,BHMT,BRAP,CBS/LOC102724560,CCND1,CCNE1,CCNG1,CDC14A,CDK2AP2,CDKL3,CDKN1A,CEBPB,CEP85,CHD1L,CHEK2,CIDEC,CLDN1,CLDN2,CLDN3,CLPX,COA7,COQ10B,CPT1A,CPT2,CRAT,CYP26A1,CYP7A1,DBP,DBT,DCAF13,DCLRE1B,DHDDS,DNAJC28,DTX3L,DUSP19,DUSP6,EFNA1,ENC1,ERLIN1,ETNPPL,FAM117A,FAM216A,FAS,FBXO31,FMO3,FOXA1,FOXA2,FOXJ3,FOXO1,FZD1,GADD45B,GADD45G,GDF15,GLYAT,GNL3,GOLIM4,GOT1,GPR146,GPR37,GSTM4,GTF2E1,HAO2,HNF1A,HNF4A,HSD17B2,Hsd3b4 (includes others),HSPH1,IGFBP1,IGSF8,IL15,INHBA,IRF6,ITGA9,JUN,KLC4,KLF15,LAMC1,LDLR,LRSAM1,MBL2,MCM8,MID1IP1,MRM3,MTHFD1,NCAPD2,NCOA4,NFE2L2,NFYA,NOLC1,NOX4,NR1I2,NUDT11,ONECUT1,ORC1,OSCAR,PALMD,PARP9,PCDH20,PCYT1A,PEX16,PEX6,PITPNB,PKP2,PLA2G4A,POR,PPARD,PPARGC1A,PPCS,PPFIBP2,PPL,PPME1,PPP1R3C,PRELID2,PRELID3B,PSAT1,QRSL1,QTRT2,RAB30,RABGEF1,RAD17,RBM48,RPS18,RSAD2,SEC24D,SERPINA10,SERPINB8,SERPINE1,SESN2,SFSWAP,SGK2,SH3PXD2A,SLC16A6,SLC17A2,SLC25A32,SLC38A4,SNX11,SPATA2,SPATS2L,STARD7,STOM,SUPT7L,TACO1,TADA3,TAT,TBCK,TCF7L2,TDO2,TDRKH,TFRC,TIMM17A,TMEM140,TMTC4,TNFAIP1,TNFRSF11B,TRMT6,USP2,VMP1,WDCP,WDR77,WNT4,XBP1,ZBED3,ZFYVE19,ZNF189 | 456 (24) |
| USP19 | 3.50e-01 | peptidase | NA | 1.25e+00 | 0.0e+00 | BIRC2,BIRC3,CBLB,DDIT4,FKBP5,KLF15,NR3C1,PFKFB3 | NA |
| ursolic acid | NA | chemical drug | NA | 1.24e+00 | 0.0e+00 | ATF3,CCND1,CDKN1A,CNTF,FASN,GDF15,MOG,NR3C1,SLC38A2,STAT3 | 437 (23) |
| DIO2 | 2.20e-01 | enzyme | NA | 1.24e+00 | 1.0e-02 | ASPA,ATF3,CIRBP,DDIT4,GADD45G,GREM2,INHBA,KLF15,MYOM1,NR4A2,PPARGC1A,RBM3,SLC10A6,TUBA3E | NA |
| thioacetamide | NA | chemical toxicant | NA | 1.23e+00 | 0.0e+00 | AACS,ADAMTS1,ASNS,BHLHE40,BIRC3,Cd24a,CHRNA2,CIDEC,Ctla2a,EDNRB,FANCB,GOT1,GTPBP4,IGFBP1,JUN,LIN7A,NFE2L2,ODC1,PAX8,PCSK6,POR,RBM3,SERPINA7,SLC34A2,TGFB1,Tsc22d3,USP2 | 469 (17) |
| NVP-TAE684 | NA | chemical drug | NA | 1.23e+00 | 0.0e+00 | BCL2L11,CCND1,CCND2,CD274,ETV5,PTP4A1,SERPINE1,VCAN | 407 (19) |
| imatinib | NA | chemical drug | NA | 1.22e+00 | 0.0e+00 | ATP1B1,AURKA,BCL2L11,BIRC2,CCND1,CCND2,CCNE1,CD274,CDKN1A,CEBPB,ETV5,HDAC2,Ifi47,IFIT3,IFRD1,Igtp,IRF1,LYN,MADD,MAPK6,MKNK2,PPIF,SOCS2,STAT3,TADA3,TFRC,TGFB1,TNFAIP3 | 382 (22) |
| ADCYAP1 | -1.50e-01 | other | NA | 1.22e+00 | 2.0e-02 | ADCYAP1R1,AMACR,AZIN1,BTG2,CEBPB,CLCF1,ELAVL1,FGFR2,GCLM,GREM2,ID3,IRF1,MOG,POR,RHOB,TK1,TMPO,TSC22D1 | NA |
| trovafloxacin | NA | chemical drug | NA | 1.21e+00 | 0.0e+00 | BHLHE40,BIRC3,CDKN1A,CLDN14,CYP7A1,FASN,GNPNAT1,IGFBP1,Igtp,IRF1,LDLR,SERPINE1,SLCO1B3,SOCS2,STAT3,TAT,TNFAIP3 | 366 (12) |
| LRAT | -1.80e-01 | enzyme | NA | 1.21e+00 | 0.0e+00 | CCNE1,CDKN1A,CYP26A1,PPARD,RBP7 | NA |
| HDAC7 | -8.00e-02 | transcription regulator | NA | 1.21e+00 | 0.0e+00 | CCND1,CDKN1A,DLL4,ETNPPL,IGFBP1,RPRM | 235 (12) |
| MACROH2A1 | NA | other | NA | 1.20e+00 | 0.0e+00 | CCND2,CDKN1A,FASN,FITM2,GCK,HIF3A,MAP2K6,PTPRO,SERPINA7,SERPINE1,SLC7A2,SOCS2 | NA |
| promegestone | NA | chemical drug | NA | 1.20e+00 | 0.0e+00 | BIRC3,BTG2,CCND1,CCNE1,CDKN1A,CEBPB,FKBP5,HSD17B2,IFIT3,NET1,STAT3,TK1 | 466 (25) |
| CEBPA | 1.00e-01 | transcription regulator | NA | 1.19e+00 | 0.0e+00 | AGT,ARG1,ASL,ASNS,ASS1,BHMT,BTG2,CCND1,CCND2,CDKN1A,CEBPB,CPT1A,CSF3R,CYP7A1,FASN,FOXA2,FOXO1,FZD1,HNF1A,ID2,IL1RN,IL6R,IRF6,JUN,NR1I2,NR4A2,OAS2,ONECUT1,PCSK6,PLXND1,PPARD,PPARGC1A,PPL,PPP1R3C,SECTM1,SERPINE1,THRB,VCAN,ZBTB48 | 488 (21) |
| mitomycin C | NA | chemical drug | NA | 1.18e+00 | 0.0e+00 | ATF3,ATP23,BCL2L11,BTG2,CCND1,CDKN1A,FAS,IRF2BP2,JUN,PARP2,PYCARD,SESN2,TP53INP1,VMP1,WEE1 | 418 (24) |
| RAB2A | -2.00e-02 | enzyme | NA | 1.18e+00 | 1.0e-02 | CIDEC,FASN,PLIN4,PLIN5 | NA |
| docosahexaenoic acid | NA | chemical drug | NA | 1.17e+00 | 0.0e+00 | ARG1,BACH1,CDKN1A,CEBPB,CPT1A,FAS,FASN,FOXO1,IGFBP1,INSIG2,LDLR,NFE2L2,NOX4,PIK3R1,PLA2G4A,PNPLA2,SERPINE1,TGFB1 | 386 (25) |
| RB1CC1 | 1.00e-01 | other | NA | 1.17e+00 | 0.0e+00 | CCND1,CDKN1A,RB1,SERPINE1 | 389 (26) |
| mir-26 | -4.00e-02 | microRNA | NA | 1.17e+00 | 1.0e-02 | CCND2,CCNE1,CHORDC1,PFKFB3,RB1 | NA |
| METTL3 | -2.30e-01 | enzyme | NA | 1.16e+00 | 0.0e+00 | ASAP3,BTG2,CDKN1A,CGREF1,CISH,EGF,ELAVL1,Esrra,FAS,JUN,LPIN1,PPARGC1A,RB1,RPRM,TBC1D8 | 199 (15) |
| methapyrilene | NA | chemical drug | NA | 1.16e+00 | 0.0e+00 | ALDOA,AMACR,ASS1,ATF3,ATP6V1B2,AZIN1,BHMT,BTG2,CBS/LOC102724560,CCND1,CCNG1,CPT1A,CYP7A1,IFRD1,IGFALS,IGFBP1,LGALS9B,MAPK6,Mx2,ODC1,RIPK3,SLC3A2 | NA |
| NFE2L2 | -1.39e+00 | transcription regulator | NA | 1.16e+00 | 0.0e+00 | ADAMTS1,AGT,ALDOA,ATF3,B4GALNT1,BHMT,CDKN1A,CHORDC1,CPT1A,DYNLL1,EPB41,ETV6,FASN,FKBP5,Fus,GADD45G,GCLM,GNA14,GOT1,GSTM4,GSTT2/GSTT2B,HERPUD1,HMGCS1,HNF1A,IFRD1,IL1RN,IL6R,KIFC2,MAP1LC3B,MSMO1,NFE2L2,NOCT,OSCAR,OSGIN1,PIK3R1,PPARGC1A,PPARGC1B,PREP,PSAT1,PTPN1,PTPRO,RSAD2,SERPINE1,SLC1A4,SLCO1B3,TGFB1,TK1,UBC,UGDH,XBP1 | 400 (18) |
| 1-chloro-2-(2,2,2-trichloro-1-(4-chlorophenyl)ethyl)benzene | NA | chemical toxicant | NA | 1.15e+00 | 0.0e+00 | CDKN1A,CYP17A1,GADD45B,INSIG2 | 395 (15) |
| maslinic acid | NA | chemical - endogenous non-mammalian | NA | 1.15e+00 | 0.0e+00 | CCND1,CCND2,CEBPB,CPT2,FAS,LIMK2,MAP2K6,PIK3R1,PNPLA2,PPARD,SOS1,TGFB1 | 459 (22) |
| TWIST2 | -1.20e-01 | transcription regulator | NA | 1.14e+00 | 0.0e+00 | CCND1,CDKN1A,DUSP6,MAF,OSGIN1,PPARGC1A,PRKAA1,TGFB1 | 301 (13) |
| EWSR1-FLI1 | NA | fusion gene/product | NA | 1.14e+00 | 0.0e+00 | BIRC3,CCND1,CDKN1A,EDNRA,GPR37,NFKBIZ,NREP,NRXN2,PTPRO,S1PR1,SERPINE1,TNFAIP3 | 200 (7) |
| calyculin A | NA | chemical toxicant | NA | 1.13e+00 | 0.0e+00 | CCND1,CCND2,CCNE1,CDKN1A,IL21R,ODC1,SLC12A3 | 361 (21) |
| ARID2 | -6.00e-02 | transcription regulator | NA | 1.13e+00 | 1.0e-02 | ALPL,CD274,EXT1,FGFR2,NR3C1,NREP,SOX5 | NA |
| mirdametinib | NA | chemical drug | NA | 1.13e+00 | 2.0e-02 | BCL2L11,CHKA,DDIT4,TFRC,TGFB1 | NA |
| Vhl | NA | complex | NA | 1.13e+00 | 0.0e+00 | BIRC2,BIRC3,CCND1,TGFB1 | 233 (10) |
| PTH | NA | other | NA | 1.12e+00 | 0.0e+00 | ADAMTS1,ALPL,BHLHE40,CCND1,CDKN1A,CEBPB,CREM,ID4,IL33,IL6R,JUN,LIMA1,NR4A2,ODC1,Plekha6,RGS1,SDC4,SEC22B,STC1,TGFB1,TNFRSF11B,TNS1,WNT4 | 397 (22) |
| nickel | NA | chemical toxicant | NA | 1.12e+00 | 2.0e-02 | IL1RN,JUN,NUPR1,SERPINE1 | NA |
| E2F1 | 1.90e-01 | transcription regulator | NA | 1.12e+00 | 0.0e+00 | ADIPOR2,ALPL,AURKA,BCL2L11,CCND1,CCND2,CCNE1,CCNF,CD274,CDCA4,CDKN1A,CHEK2,CPT2,DDB2,Esrra,FAS,FGFR2,FOXO1,HNRNPD,ID3,IDH3A,KCNH1,MAF,MAP3K14,MAP3K5,MCM10,MTHFD1,NRIP1,ORC1,PAWR,PIK3R1,POLA1,PPARGC1A,PPP1R13B,PPP1R26,PSAT1,RB1,RND3,SERPINE1,SLC3A2,TGFB1,TGM1,TK1,TP53INP1,UGDH,VRK1,WEE1,ZNF672 | 307 (14) |
| imipramine blue | NA | chemical drug | NA | 1.12e+00 | 2.0e-02 | AURKA,CCND1,CCNF,FOXRED2,GSTO2 | NA |
| STAT3 inhibitor VI | NA | chemical reagent | NA | 1.11e+00 | 2.0e-02 | AGT,BCL2L11,CD274,TGFB1 | NA |
| PIK3CG | -5.60e-01 | kinase | NA | 1.11e+00 | 3.0e-02 | ARG1,BCL2L11,GBP2,Igtp,IRF1,OAS2,OSCAR,SECTM1,TGFB1,TK1 | NA |
| eflornithine | NA | chemical drug | NA | 1.11e+00 | 2.0e-02 | CDKN1A,ODC1,ORC1,RB1,SERPINE1,SLC3A2 | NA |
| RYR2 | -4.20e-01 | ion channel | NA | 1.11e+00 | 1.0e-02 | CAPN10,CEBPB,EDEM1,FOXO1,PPARGC1A | 281 (7) |
| EFNA4 | -1.90e-01 | kinase | NA | 1.11e+00 | 4.0e-02 | DUSP6,ETV5,FOXA2,IRF1,TGM1 | NA |
| BCL2L11 | 1.06e+00 | other | NA | 1.10e+00 | 2.0e-02 | BCL2L11,CCND1,CD274,TGFB1 | NA |
| indomethacin | NA | chemical drug | NA | 1.10e+00 | 0.0e+00 | ADAMTS1,ASNS,BIRC3,BTG2,CCND1,CDKN1A,CEBPB,CLDN1,CPT1A,Ctla2a,DYNLL1,FASN,GDF15,GTPBP4,IGFBP1,IL17RB,LDLR,LIMA1,NR1I2,PLA2G4A,PPARD,RBM3,REN,SLC34A2,SLC7A5,VCAN | 414 (20) |
| HTT | 4.00e-02 | transcription regulator | NA | 1.09e+00 | 0.0e+00 | AGT,ALDOA,AMACR,AMD1,ATF3,ATL2,ATP2B2,AZIN1,BAIAP2,BCL2L11,BCL3,BHLHE40,BIRC2,C1QTNF3,CA12,CCND1,Cd24a,CDKN1A,CEBPB,CHKA,CLDN1,DBP,DLL1,DUSP6,EDNRB,Esrra,ETNPPL,FABP7,FASN,FDFT1,GADD45G,GCLM,HMGCS1,IL15,ITPR1,JUN,KLF9,LDLR,MAST3,MEIS2,NFE2L2,NR4A2,NREP,PER1,PER2,POR,PPARD,PPARGC1A,PPARGC1B,SCAMP5,SEC22B,SGTB,SIRPA,SLC25A22,SOCS2,TFRC,THRB,UBE2G2,USP2,XBP1 | 468 (25) |
| INSIG2 | -6.60e-01 | other | NA | 1.09e+00 | 1.0e-02 | FASN,FDFT1,INSIG1,LDLR | 157 (8) |
| RPS6KB1 | 1.50e-01 | kinase | NA | 1.09e+00 | 1.0e-02 | CCND1,CCNE1,CDKN1A,DHCR24,RB1,SERPINE1 | NA |
| testosterone | NA | chemical - endogenous mammalian | NA | 1.09e+00 | 0.0e+00 | ALDOA,AMD1,ATP1B1,BCL3,CCND1,CCNE1,CDKN1A,DDIT4,DFFB,DHCR24,EGF,FAS,FGFR2,FOXO1,ID3,IGFBP1,IL33,INHBA,JUN,MX1,Mx2,ODC1,PDE3B,PIK3R1,PPP2CA,PTP4A1,REN,STAT3,SYK,TK1,TNFRSF11B,VCAN,XBP1 | 518 (22) |
| prostaglandin A2 | NA | chemical - endogenous non-mammalian | NA | 1.08e+00 | 0.0e+00 | CCND1,CDKN1A,ELAVL1,LPAR6 | 290 (18) |
| ACLY | -4.90e-01 | enzyme | NA | 1.08e+00 | 4.0e-02 | FASN,GDF15,IDH3A,PPARGC1A | NA |
| acetaminophen | NA | chemical drug | NA | 1.07e+00 | 1.0e-02 | AMACR,APEX1,ASL,BTG2,CCND1,CCNG1,CDKN1A,CEBPB,FAS,GCLM,HMGCS1,IFRD1,IGFBP1,JUN,NFE2L2,ODC1,PNPLA2,PPARGC1B,PTPN1,UGDH | 425 (23) |
| trans-cinnamaldehyde | NA | chemical drug | NA | 1.07e+00 | 0.0e+00 | CDKN1A,CYP7A1,FAS,NFE2L2,POR,SERPINE1 | 258 (10) |
| OSMR | 1.60e-01 | transmembrane receptor | NA | 1.07e+00 | 0.0e+00 | BCL3,BIRC3,CISH,FASN,GBP2,Ifi47,Igtp,IL6R,Irgm1,Mx2,Oasl2,RASL11A,STAT3 | 238 (14) |
| A-769662 | NA | chemical reagent | NA | 1.07e+00 | 1.0e-02 | ARG1,FASN,PPARGC1A,SERPINE1 | 351 (18) |
| pimozide | NA | chemical drug | NA | 1.07e+00 | 1.0e-02 | CCND1,CCND2,CISH,PRKAA1 | 77 (3) |
| BMP7 | -1.50e-01 | growth factor | NA | 1.07e+00 | 1.0e-02 | ADGRL2,ASL,CDKN1A,CEBPB,Esrra,FASN,ID2,ID3,IL1RN,MADD,MAP3K5,PCSK6,PIK3R1,PPARGC1A,PPARGC1B,PTPN1,SERPINE1,TGFB1,VCAN | 359 (19) |
| jasminoidin | NA | chemical drug | NA | 1.07e+00 | 1.0e-02 | CCNG1,CIRBP,EGF,FABP7 | NA |
| GNL3 | 7.70e-01 | other | NA | 1.07e+00 | 2.0e-02 | CCNE1,CDKN1A,EDNRA,RB1 | NA |
| GW7647 | NA | chemical drug | NA | 1.07e+00 | 3.0e-02 | CPT1A,IGFBP1,NPC1,PPARGC1A | NA |
| telmisartan | NA | chemical drug | NA | 1.07e+00 | 5.0e-02 | AGT,CLEC10A,CPT1A,NR4A2,PPARD,TGFB1 | NA |
| ILF3 | -9.00e-02 | transcription regulator | NA | 1.07e+00 | 2.0e-02 | ATF3,CCNE1,CHKA,FKBP5,ID2,IL1RN,LDLR,MAFB,SLC3A2 | NA |
| IL33 | -9.90e-01 | cytokine | NA | 1.06e+00 | 0.0e+00 | ADAMTS1,ALDOA,ARG1,ATP10A,BCL2L11,BCL3,BIRC3,CCND1,CISH,CREM,CSF3R,EPHX2,FAS,FGR,GADD45B,ID2,IL15,IL17RB,IL1RN,IL33,LMO4,NFKBIZ,NLRP3,NR3C1,ODC1,P4HA1,PSAT1,RAMP1,RGS1,SDC4,SERPINB9,SERPINE1,SNX24,SOS1,ST3GAL5,TGFB1,TNFAIP3,VMP1,ZC3H12A | 409 (18) |
| (+)-MK-801 | NA | chemical drug | NA | 1.04e+00 | 3.0e-02 | ALDOA,ATP2B2,CCND1,CDKN1A,CREM,IL6R,JUN,STAT3 | NA |
| bardoxolone | NA | chemical drug | NA | 1.04e+00 | 0.0e+00 | CCND1,CDKN1A,CEBPB,GCLM,HERPUD1,UGDH | 478 (20) |
| GDF15 | -1.32e+00 | growth factor | NA | 1.04e+00 | 0.0e+00 | CCND1,CDKN1A,GDF15,PNPLA2,RND3,SERPINE1 | 438 (27) |
| cobalt chloride | NA | chemical reagent | NA | 1.04e+00 | 0.0e+00 | ADAMTS1,ALDOA,BACH1,BHLHE40,CD274,CDKN1A,DDIT4,HIF3A,NCOA4,PFKFB3,RGS1,TFRC | 407 (19) |
| 1,2-dithiol-3-thione | NA | chemical reagent | NA | 1.04e+00 | 1.0e-02 | ALDOA,B4GALNT1,BHMT,CHORDC1,DYNLL1,EPB41,ETV6,FKBP5,GCLM,GNA14,GSTT2/GSTT2B,MSMO1,NFE2L2,NOCT,PSAT1,TFRC,XBP1 | NA |
| FHL2 | 2.90e-01 | transcription regulator | NA | 1.04e+00 | 3.0e-02 | ARG1,BCL2L11,CCND1,CLEC10A,S1PR1,TGFB1 | NA |
| prednisolone | NA | chemical drug | NA | 1.03e+00 | 0.0e+00 | ALS2,ARG1,BIRC2,BIRC3,DLL1,DRAM2,EDNRA,FAS,FKBP5,Irgm1,KLF9,LIMK2,MAP1LC3B,NR3C1,PRKAA1,RB1,RECQL4,SPON2,TGFB1,TNFAIP3,TNFRSF11B | 347 (16) |
| ID3 | -6.90e-01 | transcription regulator | NA | 1.02e+00 | 0.0e+00 | BCL2L11,BCL3,BTG2,CCND2,CCNE1,CCNG1,CDKN1A,CEBPB,FOXO1,GADD45B,GADD45G,GNL3,ID3,IL17RB,IL6R,IRF6,LMO4,MAF,MAP2K6,MAP3K14,PAWR,PIK3IP1,PIK3R1,PREP,RPRM,SOX5 | 358 (13) |
| SLC7A11-AS1 | NA | other | NA | 1.02e+00 | 0.0e+00 | CCND1,GCLM,JUN,MAP3K5 | NA |
| sulforafan | NA | chemical drug | NA | 1.02e+00 | 3.0e-02 | ADAMTS1,AGT,CCND1,CDKN1A,FAS,Fus,GCLM,GSTT2/GSTT2B,HAO2,IGFBP1,IL6R,KLHL7,LAMC1,NFE2L2,PIK3R1,PPARGC1B,TBC1D8,TK1,TTLL12 | NA |
| bezafibrate | NA | chemical drug | NA | 1.01e+00 | 0.0e+00 | Acot1,APEX1,CHKA,CYP7A1,FASN,HNF4A,INSIG1,JUN,NPC1,PEX11A,PPARGC1A,SERPINE1 | 381 (20) |
| resiquimod | NA | chemical drug | NA | 1.01e+00 | 0.0e+00 | ANKRD33B,ATF3,ATP6V1B2,BTBD19,CCND2,CD180,CEBPB,CTPS1,CXCL11,DLL1,DLL4,EIF2B3,FAS,GDF15,HERPUD1,HHEX,IFI44L,IFIT3,IL15,IL21R,IL33,INHBA,JUN,LYN,LYST,MX1,NFE2L2,NFKBIZ,NLRP3,OAS2,PTPN1,PYCARD,TFRC,TNFAIP3,XBP1,ZC3H12A,ZFP36L1 | 284 (16) |
| SOCS3 | -2.50e-01 | phosphatase | NA | 1.01e+00 | 0.0e+00 | ARG1,ATF3,CCND1,CDKN1A,FASN,IGFALS,IL1RN,IRF1,JUN,MX1,Mx2,OAS2,PCSK9,PPARGC1A,STAT3,TGFB1 | 425 (22) |
| R-WIN 55,212 | NA | chemical reagent | NA | 1.01e+00 | 4.0e-02 | CCND1,CCND2,CCNE1,RB1 | NA |
| 4-phenylbutyric acid | NA | chemical - endogenous mammalian | NA | 1.00e+00 | 2.0e-02 | ADIPOR2,ASPA,CCND1,CDKN1A,EDEM1,LPAR6,MOG,NLRP3,NUPR1,PEX11A,XBP1 | NA |
| mir-223 | NA | microRNA | NA | 1.00e+00 | 0.0e+00 | CCND1,CCNE1,CD180,CD274,EGF,FNIP2,FOXO1,GALC,HMGCS1,ID2,IL1RN,MSMO1,NLRP3,RIPK3,SGPL1,SOX6,STAT3 | 388 (17) |
| erastin | NA | chemical drug | NA | 1.00e+00 | 0.0e+00 | CDKN1A,GCLM,MAP1LC3B,NCOA4,TFRC | 287 (10) |
| soloxolone methyl | NA | chemical reagent | NA | 1.00e+00 | 0.0e+00 | IFI44,RSAD2,RTP4,SERPINE1 | NA |
| fontolizumab | NA | biologic drug | NA | 1.00e+00 | 1.0e-02 | FAS,IL15RA,MX1,RSAD2 | NA |
| SLC29A1 | -4.90e-01 | transporter | NA | 1.00e+00 | 1.0e-02 | CCNG1,CDKN1A,FAS,TP53INP1 | 254 (13) |
| FDFT1 | -6.10e-01 | enzyme | NA | 1.00e+00 | 1.0e-02 | CYP7A1,FASN,PCSK9,SQLE | NA |
| diethylmaleate | NA | chemical toxicant | NA | 1.00e+00 | 1.0e-02 | BIRC2,CDKN1A,SLC3A2,TNFAIP3 | 349 (14) |
| naringenin | NA | chemical - endogenous non-mammalian | NA | 1.00e+00 | 1.0e-02 | CPT1A,LDLR,LYN,NR3C1,PPARGC1A,TGFB1 | NA |
| AZD8055 | NA | chemical drug | NA | 1.00e+00 | 1.0e-02 | BCL2L11,CCND2,CYP17A1,FOXO1 | NA |
| MFSD2A | 1.74e+00 | transporter | NA | 1.00e+00 | 2.0e-02 | FASN,FDFT1,INSIG1,LDLR | NA |
| dexamethasone phosphate | NA | chemical drug | NA | 1.00e+00 | 2.0e-02 | DDIT4,GADD45G,ID3,TNFRSF11B | NA |
| THZ2 | NA | chemical drug | NA | 1.00e+00 | 2.0e-02 | CCND1,CDKN1A,TCF7L2,WEE1 | NA |
| Nppb | NA | other | NA | 1.00e+00 | 2.0e-02 | ADRA1B,EIF2B3,PRKAG2,RND3 | NA |
| ZBTB18 | NA | transcription regulator | NA | 1.00e+00 | 2.0e-02 | CHSY3,KANK2,PIK3R1,STC1 | NA |
| ECSIT | 6.00e-02 | transcription regulator | NA | 1.00e+00 | 3.0e-02 | BCL3,IL1RN,NR4A2,TNFAIP3 | NA |
| TFPI2 | -4.10e-01 | other | NA | 1.00e+00 | 4.0e-02 | ATF3,BTG2,CCND1,GADD45B | NA |
| CYP27B1 | 2.20e-01 | enzyme | NA | 1.00e+00 | 5.0e-02 | ALPL,CCND1,IL15,STAT3,TRPV6 | NA |
| USP18 | -2.80e-01 | peptidase | NA | 1.00e+00 | 5.0e-02 | BCL2L11,IL15,IRF1,MX1 | NA |
| EIF2AK4 | 5.00e-02 | kinase | NA | 1.00e+00 | 0.0e+00 | ASNS,ATF3,CIDEC,DDIT4,FASN,GCK,MOG,NFE2L2,PSAT1 | 277 (7) |
| metformin | NA | chemical drug | NA | 9.90e-01 | 0.0e+00 | ADIPOR2,ALDOA,ARG1,ARRDC3,ATF3,Atp8b5,BCL3,CCND1,CCND2,CCNE1,CD274,CDKN1A,CEBPB,CIDEC,DDIT4,FASN,GADD45B,GADD45G,GDF15,HMGCS1,IFI44,Ifi47,IL17RB,IL1RN,INHBA,INSIG1,MX1,NFE2L2,PARP14,PPARGC1A,PPARGC1B,SERPINE1,SLC25A30,SOS1,TGFB1,XBP1,ZFYVE19 | 480 (25) |
| epigallocatechin-gallate | NA | chemical drug | NA | 9.90e-01 | 2.0e-02 | BIRC2,CCND1,CDKN1A,CEBPB,FAS,GADD45B,HDAC2,Ifi47,IRF1,JUN,LDLR,MAP3K5,NFE2L2,NR4A2,SERPINE1,STAT3,TFRC,TGFB1 | NA |
| S-nitroso-N-acetyl-DL-penicillamine | NA | chemical reagent | NA | 9.80e-01 | 2.0e-02 | CCNE1,CDKN1A,FAS,LDLR,PPARD,PPARGC1A,TGFB1 | NA |
| CREM | -7.90e-01 | transcription regulator | NA | 9.80e-01 | 0.0e+00 | ATF3,BHLHE40,BTG2,CCND1,CCND2,CEBPB,CIART,CREM,GADD45B,HAND2,HMGCS1,LDLR,MKNK2,MSMO1,NR4A2,PER1,REN,RHOB | 352 (19) |
| gefitinib | NA | chemical drug | NA | 9.80e-01 | 0.0e+00 | ADAMTS1,AURKA,BCL2L11,BTG2,CCND1,CCNE1,CCNF,CD274,CEBPB,CHEK2,EFNA1,ETV5,FGFR2,FSCN1,GADD45B,ID4,LPIN1,MAP2K6,MCM8,NOX4,NRP2,PCDH12,PPP2R2B,RAD18,RHOB,SOS1,TP53INP1 | 435 (21) |
| KLF6 | -1.80e-01 | transcription regulator | NA | 9.70e-01 | 0.0e+00 | AGT,ALDOA,ARG1,ATF3,BCL2L11,BCL3,BIRC3,CD274,CDKN1A,CEBPB,CLCF1,EXT1,GADD45B,HNF4A,ID2,IL15RA,IRF1,LYN,MSLN,NFE2L2,NLRP3,PARP14,PFKFB3,PLA2G4A,PTPN1,RHOB,SERPINB8,SLC16A6,SPSB1,STAT3,TGFB1,TNFAIP3,VCAN,ZC3H12A,ZNFX1 | 390 (18) |
| Ngf | NA | group | NA | 9.70e-01 | 1.0e-02 | BCL2L11,CCND1,CDKN1A,JUN,NR4A2,ODC1,PPARGC1A,SERPINE1,TGFB1 | 374 (23) |
| PPARD | 8.50e-01 | ligand-dependent nuclear receptor | NA | 9.70e-01 | 0.0e+00 | ARG1,ASS1,C11orf86,CCND1,CCND2,CCNE1,CEBPB,CERS3,CPT1A,CPT2,CYP7A1,DET1,FABP7,FASN,GCK,HMGCS1,IFI44L,IGFBP1,Irgm1,LDLR,MFSD2A,MOG,NR4A2,OAF,PCSK6,PCSK9,PNPLA2,PPARD,PPARGC1A,PPARGC1B,ST3GAL5,STBD1,Tlr12,TMEM120A,TNFAIP3,TNFRSF11B,UBC | 369 (18) |
| CGA | NA | other | NA | 9.70e-01 | 1.0e-02 | ADAMTS1,BIRC2,CCND1,ETV5,FOXO1,HERPUD1,KLF9,NUPR1,SGTB,TP53INP1,ZNF385B | 360 (16) |
| NQO1 | -1.00e-02 | enzyme | NA | 9.70e-01 | 3.0e-02 | ALDOA,BIRC2,BIRC3,CCND1,CDKN1A,CSF3R | NA |
| P38 MAPK | NA | group | NA | 9.70e-01 | 0.0e+00 | ASS1,ATF3,CCND1,CCND2,CCNE1,CCNF,CDKN1A,CEBPB,CXCL11,DDB2,DIO3,DUOX2,EDNRB,FAS,ID3,IL1RN,INHBA,IRF6,IRX1,JUN,KLF15,LAMA3,NFE2L2,PLA2G4A,PPARGC1A,RB1,RHOB,RND3,SERPINE1,TGFB1 | 463 (22) |
| thyroid hormone | NA | chemical - endogenous mammalian | NA | 9.70e-01 | 1.0e-02 | AGT,BTG2,CCND1,CDKN1A,CPT1A,CRAT,CYP7A1,EGF,FASN,FDFT1,KLF9,PER1,PPP2CA,SEMA6B,THRB,UGP2 | 431 (20) |
| ANGPT2 | -3.30e-01 | growth factor | NA | 9.60e-01 | 2.0e-02 | AGT,BCL2L11,CDKN1A,CEBPB,CWC22,EPHX2,FAS,HDAC2,HMGCS1,KPNA2,LYN,NOX4,POLA1,RHOB,SERPINE1,SLC12A3,TGFB1 | NA |
| lomustine | NA | chemical drug | NA | 9.60e-01 | 3.0e-02 | ASNS,BIRC3,Ctla2a,GTPBP4,IGFBP1,RBM3,SLC34A2 | NA |
| GLI3 | 1.20e-01 | transcription regulator | NA | 9.60e-01 | 3.0e-02 | CCND1,CCND2,DLL1,FOXA2,FOXO1,HAND2,IRF1,NFKBIZ,TNFAIP3 | NA |
| metribolone | NA | chemical reagent | NA | 9.50e-01 | 0.0e+00 | ADAMTS1,ALDOA,ANKH,ARG1,ATP1B1,CCND1,CDC14B,CDKN1A,COX10,CPT2,DHCR24,DLAT,EDEM1,ELL2,FASN,FDFT1,FKBP5,FLVCR2,FOXO1,GADD45G,GALE,GDF15,GOT1,HMGCS1,HSPH1,IDH3A,INSIG1,LDLR,LRIG1,MAF,NCOA4,NNMT,PFKFB2,POR,RRAGD,RRP12,SEC24D,SLC1A4,SLC38A2,SPON2,TAT,TIMM10,TRIM36,TSC22D1,UGDH,VCAN,WEE1 | 453 (24) |
| KRAS | 1.80e-01 | enzyme | NA | 9.50e-01 | 0.0e+00 | ADAMTS1,AGT,AKAP5,ALDOA,ARG1,ATAD3A,ATF3,ATOH8,ATP1B1,AURKA,BIRC3,CCND1,CD274,CDKN1A,CDT1,CEBPB,CHST3,CLEC10A,CSF3R,DUSP6,EDEM1,EFNA1,ETV5,EXT1,FAS,FASN,GALNT10,GCLM,HNRNPD,IL33,IRF1,JUN,LAMA3,LGALS9B,LMNB1,MADD,MAP1LC3B,MID1IP1,MSLN,MTHFD1,MX1,NFE2L2,NFYB,NLRP3,NPC1,NR3C1,NRN1,Oasl2,ODC1,PALLD,PAWR,PLD1,POR,PPARD,PSTPIP1,PYCARD,QTRT2,RHOB,RRP12,SDC4,SERPINE1,SIRPA,SLC25A32,SLC34A2,SLC3A2,SLC7A10,SNX16,SOS1,ST3GAL6,STAT3,STOM,TGFB1,TIMM10,TINAGL1,TK1,TNFRSF11B,UNC5B,VCAN,VMP1,WEE1,ZFAND2A,ZFP36L1 | 470 (23) |
| JARID2 | -1.10e-01 | transcription regulator | NA | 9.40e-01 | 0.0e+00 | CCND1,CCND2,CCNE1,CDKN1A,PPARGC1A,RB1,TGFB1 | 388 (22) |
| ONECUT1 | -1.56e+00 | transcription regulator | NA | 9.30e-01 | 0.0e+00 | AASS,ABL2,AKR1C4,CLDN2,CYP7A1,DDB2,FAM117A,FAS,FASN,FOXA2,GTF2E1,HNF4A,HSPH1,IRF6,NDUFAF4,NOLC1,NR1I2,ONECUT1,ORC1,PEX6,PFKFB1,PPARD,PPFIA1,RBM48,SERPINB8,TAT,TBCK,TDO2 | 143 (5) |
| IGBP1 | -5.00e-02 | phosphatase | NA | 9.30e-01 | 0.0e+00 | CLDN1,CLDN3,ELAVL1,IRF1 | 100 (4) |
| USP28 | -1.10e-01 | peptidase | NA | 9.30e-01 | 0.0e+00 | CCND1,CD274,CDKN1A,PLK3 | 406 (20) |
| CYB5R4 | -2.10e-01 | enzyme | NA | 9.30e-01 | 1.0e-02 | ATF3,FASN,PPARGC1A,XBP1 | NA |
| BCAP31 | 6.00e-02 | transporter | NA | 9.20e-01 | 0.0e+00 | ARG1,CEBPB,EDEM1,GCK,INSIG1,IRF1,IRF6,XBP1 | 288 (9) |
| Calcineurin protein(s) | NA | complex | NA | 9.20e-01 | 1.0e-02 | BCL2L11,CBLB,ITPR1,LIN7A,NR4A2,PPARGC1A,Rcan1,SERPINE1,STAT3 | 442 (25) |
| KITLG | -5.00e-01 | growth factor | NA | 9.10e-01 | 0.0e+00 | ATP6V1B2,BCL2L11,CCNE1,Cd24a,CDKN1A,CIAPIN1,CISH,CSF3R,CYTH1,DHCR24,EDNRB,ID2,IL1RN,KPNA2,LDLR,MAPK11,MID1IP1,MYOM1,N4BP2L1,NR3C1,PIK3IP1,PTGER3,SEC22B,SF3A1,SMARCD2,STAT3,SYK,WEE1 | 349 (21) |
| cocaine | NA | chemical drug | NA | 9.10e-01 | 3.0e-02 | Acot1,BHLHE40,CPT1A,CPT2,DYNLL1,FOXO1,GADD45B,INHBA,JUN,MAP2K6,MKNK2,MX1,PER1,SLC16A10,UBASH3B | NA |
| PTGER4 | 4.80e-01 | G-protein coupled receptor | NA | 9.10e-01 | 0.0e+00 | ARRDC3,CMPK2,GBP2,HERPUD1,Ifi47,Igtp,IRF1,Irgm1,LPAR6,MAFB,Mx2,Oas1b,PARP14,PTGER3,RNF144B,RSAD2,RTP4,S1PR1,Serpinb6b,TOR3A,TP53INP1,ZFP36L1 | 338 (11) |
| AR | -1.80e-01 | ligand-dependent nuclear receptor | NA | 9.10e-01 | 0.0e+00 | AASS,AMD1,ARG1,ASB7,B4GALNT1,BCL2L11,CAPN10,CCND1,Cd24a,CDKN1A,CDT1,CEBPB,CERS6,CITED4,CLDN3,CYP17A1,DDIT4,DHCR24,EDNRA,EDNRB,FABP7,FGFR2,FKBP5,FOXA1,FOXO1,GADD45G,GDF15,HSPH1,IGSF8,JAM3,KPNA2,LRIG1,MSI1,MSMO1,MYO1B,MYOM1,NCAPD2,NCOA4,NPC1,NR3C1,NUPR1,ODC1,P4HA1,PER1,PFKFB2,PIM3,RARRES1,RASSF3,REN,RHOB,SERPINE1,SLC3A2,SLC45A3,SMOX,SYNE1,TAT,TBC1D8,TGFB1,TIMM10,TLR6,UNC5C,VCAN,WEE1,WNT4,XBP1,ZFYVE19 | 462 (21) |
| ELAVL1 | -8.60e-01 | other | NA | 9.00e-01 | 1.0e-02 | 9930111J21Rik1/Gm12185,ATF3,CCNE1,CDKN1A,CLDN1,CLDN3,ELAVL1,HNRNPD,IFI44,IRF1,Irgm1,LGALS9B,Oas1b,OAS2,REN,STAT3,SYK,TIMM17A,TP53INP1,WEE1 | 280 (15) |
| L-triiodothyronine | NA | chemical - endogenous mammalian | NA | 9.00e-01 | 0.0e+00 | Acnat1/Acnat2,ADCY9,AGT,AMD1,ASS1,ATP1B1,BCL2L11,BCL3,BTG2,CA1,CCND1,CCNE1,CDCA4,CDKN1A,CIAPIN1,COQ10B,CPT1A,CPT2,CYP17A1,CYP7A1,DBP,DBT,DHCR24,DIO3,EFNA1,EGF,FAS,FASN,GCK,GDF15,GNA14,H2-T22,HMGCS1,Hsd3b4 (includes others),ID2,ID3,IDH3A,IGFBP1,ITPR1,KLF11,KLF9,LDLR,LRCH4,MSMO1,NCOA4,ODC1,PER1,POR,PPARGC1A,PPARGC1B,PSAT1,RAB30,RARRES1,REN,SBK1,SERPINE1,SLC16A10,SQLE,TGFB1,THRB,TK1,WNT4 | 413 (21) |
| SYVN1 | 2.00e-02 | transporter | NA | 9.00e-01 | 0.0e+00 | ADCY9,BHLHE40,CCND1,CTPS1,FAS,FASN,IFI44,NFE2L2,PNPLA2,SLC12A3,SLC3A2,SLC7A2,SLC7A5,STOM,TFRC | 338 (12) |
| PRDM16 | -2.70e-01 | transcription regulator | NA | 9.00e-01 | 0.0e+00 | AGT,CDKN1A,GADD45G,IFI44,Mx2,OAS2,PPARGC1A,SERPINE1 | 335 (18) |
| SIRT6 | 9.00e-02 | enzyme | NA | 9.00e-01 | 2.0e-02 | AACS,BIRC3,CIDEC,DBP,FASN,PPARGC1A,SERPINE1,TDO2,TGFB1 | NA |
| tofacitinib | NA | chemical drug | NA | 9.00e-01 | 0.0e+00 | CBLB,CCND1,CISH,IFIT3,SOCS2,STAT3 | 440 (24) |
| TGS1 | 1.00e-02 | enzyme | NA | 9.00e-01 | 1.0e-02 | ANKS4B,CCND1,CCND2,HERPUD1,SESN2,XBP1 | NA |
| CREB1 | -3.40e-01 | transcription regulator | NA | 8.90e-01 | 0.0e+00 | ARG1,ATF3,AURKA,BHLHE40,BTG2,CCND1,CDK19,CDKN1A,CEBPB,CGREF1,CIART,CPT1A,CREM,ETV6,FASN,FGFR2,GADD45B,GADD45G,H2-T22,HERPUD1,HMGCS1,INHBA,JUN,LDLR,MFSD2A,MKNK2,MSMO1,MTSS1,MYO1B,NR4A2,NREP,NRP2,PAX8,PCDH20,PDE3B,PER1,PER2,PIM3,PITPNB,PLA2G4A,PLXNA2,PPARGC1A,RAC3,RASGEF1B,RB1,REN,RP1,RPRM,SOCS2,STAT3,STC1,TFRC,ZDHHC23 | 397 (22) |
| ascorbic acid | NA | chemical - endogenous mammalian | NA | 8.90e-01 | 0.0e+00 | ALPL,CDKN1A,DUOX2,FAS,IL15,LDLR,NUPR1,PCSK9,SERPINE1,TFRC,TGFB1,TNFRSF11B | 366 (20) |
| APOE | 0.00e+00 | transporter | NA | 8.80e-01 | 0.0e+00 | Aox3,ATF3,C5AR2,CCND1,CCND2,CPT1A,CYP7A1,FKBP5,HERPUD1,IL1RN,IL6R,JUN,LDLR,LIMS2,MADD,MYO1B,NOX4,PCSK9,PPARD,PPARGC1B,PPFIBP2,SDC4,SEMA6B,SERPINE1,STAT3,TGFB1,TNFRSF14,VCAN,XBP1 | 380 (23) |
| miR-124-3p (and other miRNAs w/seed AAGGCAC) | NA | mature microRNA | NA | 8.80e-01 | 1.0e-02 | ABHD5,ARHGAP29,CAPRIN2,CDC14B,CHST14,CREB3L2,DFFB,DHCR24,FOXA2,KLF15,LAMC1,LDLR,LMNB1,OAF,PTTG1IP,SLC25A30,STAT3,STOM,STX2,ZBED3 | NA |
| SMARCB1 | NA | transcription regulator | NA | 8.70e-01 | 0.0e+00 | ATP1B1,AURKA,BCL2L11,CCND1,CCNE1,CDKN1A,CDT1,FAS,FGFR2,IL15RA,MCM10,MX1,MYOM1,PFKFB1,POLA1,PPP1R3C,RND3,STAT3,SYCP3 | 407 (21) |
| tamoxifen | NA | chemical drug | NA | 8.70e-01 | 0.0e+00 | ASS1,BRWD1,CCND1,CDKN1A,CYP7A1,DNAJA1,EPHA4,ETV5,FASN,GCK,GDF15,HMGCS1,IDH3A,IL1RN,IRF1,JUN,LDLR,MX1,NCAPD2,NNMT,NRCAM,RB1,SAMD11,SDS,SLC34A2,SLC7A2,SLC7A5,SYNE1,TDO2,TOR3A | 479 (24) |
| levodopa | NA | chemical - endogenous mammalian | NA | 8.60e-01 | 0.0e+00 | ALPL,ARHGEF19,BACH1,CA12,CACNB2,CAPN10,CCND1,CIART,CITED4,DBP,DUSP6,EDNRB,EFNA5,ERLIN1,FKBP5,FOXO1,GADD45B,GNE,GOLIM4,INSC,ITPKA,KLF9,MAPK11,MBNL2,MEIS2,MFSD2A,MSMO1,MTERF2,MYO1B,NOCT,Oasl2,OTULIN,PER1,PER2,PIK3R1,PINX1,PKP2,PPP1R13B,PPP2R2D,PPTC7,PRKD3,RAMP1,RELL1,S1PR2,SBK1,SCUBE3,SF3A1,SH3PXD2B,SHANK3,SLC38A2,SLC8B1,SOX5,ST3GAL5,SYNE1,TDRKH,TNFAIP1,VMP1,ZNF385B | NA |
| TMBIM6 | 6.00e-02 | other | NA | 8.60e-01 | 1.0e-02 | EDEM1,HERPUD1,MAP1LC3B,XBP1 | NA |
| Nfat (family) | NA | group | NA | 8.50e-01 | 1.0e-02 | ATF3,CCND1,ELL2,FAS,ITPR1,NOX4,OSCAR,PDE3B,RGS3,SDC4,SERPINE1 | 174 (7) |
| TRAPPC1 | 1.00e-01 | other | NA | 8.50e-01 | 2.0e-02 | CDKN1A,DNAJA1,EDEM1,HERPUD1,MAP3K5,SEC24D,UBE2G2,XBP1,YOD1 | NA |
| 5-azacytidine | NA | chemical drug | NA | 8.50e-01 | 4.0e-02 | CDKN1A,CLCF1,CLDN1,ETV5,GDF15,INHBA,MYO1B,PAH,RHOB,SERPINB8,SHANK3,SLC26A3,SLC3A2,SLC7A5 | NA |
| SPRY1 | NA | other | NA | 8.50e-01 | 3.0e-02 | ETV5,FABP7,ID2,LMO4 | NA |
| AZGP1 | 3.00e-02 | transporter | NA | 8.50e-01 | 3.0e-02 | CCND1,CEBPB,GYS1,PNPLA2 | NA |
| romidepsin | NA | biologic drug | NA | 8.50e-01 | 4.0e-02 | BCL2L11,BIRC2,CCND1,CDKN1A,DUSP6,GADD45G,JUN,RHOB | NA |
| wortmannin | NA | chemical drug | NA | 8.40e-01 | 0.0e+00 | AGT,ATF3,BCL2L11,CCND1,CCND2,CD274,CDKN1A,CIDEC,CYP17A1,FASN,GCK,IRF1,JUN,MAF,MAP1LC3B,NFE2L2,P4HA1,PPARD,RB1,SERPINE1,SOCS2,TFRC | 436 (20) |
| GFI1 | -2.80e-01 | transcription regulator | NA | 8.40e-01 | 0.0e+00 | BCL3,CCND2,CDKN1A,CHD7,DDB2,FOXO1,GADD45G,ID2,IL6R,IRF1,JUN,MAFB,MAP3K5,RB1,S1PR1,TNK2 | 349 (21) |
| INHA | 1.00e-01 | growth factor | NA | 8.40e-01 | 0.0e+00 | ADAMTS1,ADAMTSL2,CCND2,CCNE1,CYP17A1,HSD17B2,INHBA,ITGA9,PIK3IP1,PIK3R1,SERPINE1,TP53INP1 | 242 (12) |
| di(2-ethylhexyl) phthalate | NA | chemical toxicant | NA | 8.40e-01 | 1.0e-02 | Acot1,CCND2,CYP17A1,IGFBP1,JUN,PEX11A,POR | NA |
| E2F3 | -2.20e-01 | transcription regulator | NA | 8.30e-01 | 0.0e+00 | BAIAP2L1,CA12,CCND1,CCNE1,CDCA4,CDKN1A,FGFR2,ID3,INHBA,MCM10,NECTIN1,NUCKS1,ORC1,POLA1,PPP1R13B,PTGER3,RB1,SERPINE1,TK1,TMPO | 360 (20) |
| SLC13A1 | NA | transporter | NA | 8.30e-01 | 0.0e+00 | ANKS4B,CLPX,EDEM1,GALE,GBP2,Igtp,INSIG1,KLF9,NRN1,SLC38A4,SLCO1B3,UPP2,XBP1 | NA |
| ABT-737 | NA | chemical drug | NA | 8.30e-01 | 1.0e-02 | BCL2L11,CDKN1A,CEBPB,IRF1 | NA |
| BCL6 | 2.50e-01 | transcription regulator | NA | 8.30e-01 | 0.0e+00 | ADCY9,ARG1,BACH2,BCL3,CCND1,CCND2,CD274,CD79B,CDKN1A,CISH,CLEC10A,DUSP6,FAS,IL21R,IL6R,IRF1,LDLR,LPIN1,MAF,MAPK6,ORC1,PLA2G4A,PTPRO,RHOF,SERPINE1,SH3PXD2B,SOCS2,SOX5,SOX6,STAT3,SYK,TGFB1,TNFRSF14,XBP1 | 423 (19) |
| TG | 1.00e-01 | other | NA | 8.30e-01 | 5.0e-02 | CEBPB,CPT1A,CYP7A1,THRB | NA |
| COL18A1 | 2.50e-01 | other | NA | 8.20e-01 | 5.0e-02 | CCND1,DDIT4,EDNRB,EFNA1,ID3,JUN,SERPINE1,STAT3 | NA |
| ABCA1 | -3.90e-01 | transporter | NA | 8.20e-01 | 1.0e-02 | CPT1A,FASN,FDFT1,INSIG1,LDLR,PIK3R1,PPARGC1A | NA |
| ABCG1 | -4.30e-01 | transporter | NA | 8.20e-01 | 3.0e-02 | FASN,INSIG1,LDLR,PIK3R1,PPARGC1A,TGFB1 | NA |
| HLX | -3.00e-02 | transcription regulator | NA | 8.10e-01 | 0.0e+00 | Cd24a,CLDN1,GDF15,JUN,RB1,UNC5B | NA |
| filgrastim | NA | biologic drug | NA | 8.10e-01 | 0.0e+00 | ALPL,ARHGAP24,ATF3,BIRC3,BTG2,DEXI,ERLIN1,EXT1,FKBP5,GOLIM4,IFI44,IFIT3,IRF2BP2,JUN,KLF9,KLRD1,LDLR,LPAR6,LYSMD2,MAP2K6,MAPK6,MX1,NCOA4,NLRP3,P2RY10,PARP14,PATZ1,PCSK9,PFKFB2,PFKFB3,PRKAG2,PRRG4,RARRES1,RBP7,RFX5,RGS1,RSAD2,S1PR1,SLC25A22,SLC45A3,SPECC1,SPON2,SSBP3,SULT1B1,TMEM140,TSC22D1,XBP1,ZFP36L1 | NA |
| TRIB1 | 3.10e-01 | kinase | NA | 8.00e-01 | 0.0e+00 | CBLB,CPT1A,CPT2,FASN,IL15,LDLR,PRKAG2,SMARCD2,SOCS2 | NA |
| EGFR | 3.50e-01 | kinase | NA | 8.00e-01 | 0.0e+00 | AMD1,ARG1,ATAD3A,BCL2L11,CCND1,CD274,CDKN1A,CEBPB,CHKA,CLDN2,EDEM1,EGF,FABP7,FASN,GALNT10,GCLM,HERPUD1,HNRNPD,IL33,IQUB,IRF1,JUN,LAMA3,LDLR,MTHFD1,ODC1,PARP2,PLA2G4A,PTTG1IP,QTRT2,RB1,RHOB,RND3,RNMT,SERPINE1,SLC25A32,SLC7A5,STAT3,TFRC,TIMM10,TNFRSF11B,UNC5B,VCAN,WEE1,WNT4 | 401 (20) |
| troglitazone | NA | chemical drug | NA | 7.80e-01 | 0.0e+00 | Acot1,AGT,ARHGEF19,ATF3,BIRC3,C12orf42,C9orf72,CCND1,CCND2,CCNJ,CDKN1A,CIDEC,CPT2,CXCL11,CYP7A1,DHRS3,ELAVL1,FASN,GBP2,GCK,GDF15,IFRD1,JUN,LAMA3,MRPL47,NNMT,NRIP1,P4HA1,PDE3B,PEX11A,PLIN4,PPARGC1A,RB1,SERPINE1,TGFB1,WEE1 | 458 (25) |
| trametinib | NA | chemical drug | NA | 7.80e-01 | 0.0e+00 | CD274,ETV5,MAF,MX1,ROR1,TNFAIP3 | 302 (13) |
| MPT0B291 | NA | chemical reagent | NA | 7.80e-01 | 5.0e-02 | CHEK2,DDB2,MCM10,TMPO | NA |
| staurosporine | NA | chemical drug | NA | 7.80e-01 | 2.0e-02 | BTG2,CCND1,CDKN1A,CSF3R,DFFB,FAS,IGFBP1,ODC1,S1PR1,SERPINE1,TK1 | NA |
| 1,25-dihydroxyvitamin D | NA | chemical drug | NA | 7.80e-01 | 1.0e-02 | CCND1,CCND2,DBT,PPM1K,REN,SLC7A5,STAT3,Tlr12 | 279 (20) |
| RUNX1 | -2.80e-01 | transcription regulator | NA | 7.60e-01 | 0.0e+00 | APEX1,ATF3,BCL2L11,BTG2,CCND1,CCND2,CDKN1A,EDEM1,FAS,FSCN1,GNA15,GNL3,GPATCH4,ID2,Igtp,IHH,IL6R,Irgm1,ITGA9,JAM3,LGALS9B,LMO4,MAP3K6,Oasl2,PIK3R1,PLXND1,RSAD2,SERPINE1,SOX5,SOX6,ST3GAL5,STAT3,UNC5B | 433 (21) |
| valine | NA | chemical - endogenous mammalian | NA | 7.60e-01 | 0.0e+00 | Acot1,CDKN1A,HACL1,PPM1K | NA |
| CTBP2 | -1.90e-01 | transcription regulator | NA | 7.60e-01 | 4.0e-02 | CCND1,DLL4,LDLR,NPC1 | NA |
| ADRB | NA | group | NA | 7.60e-01 | 0.0e+00 | AACS,ARG1,ATF3,BHLHE40,CCND1,CCNE1,CDKN1A,CREM,DDIT4,FAM110C,FAS,GCLM,GDF15,HMGCS1,IFIT3,INSIG1,JUN,LPIN1,MSMO1,NR4A2,PPARGC1A,RSAD2,WEE1 | 393 (25) |
| IRF2 | -1.90e-01 | transcription regulator | NA | 7.60e-01 | 0.0e+00 | ARG1,CA12,CCND1,CD274,CDKN1A,CIDEC,CLDN2,CLEC10A,Ifi47,IGFBP1,IRF1,MAPK6,PFKFB3,RARRES1 | 184 (13) |
| SIRT1 inhibitor III | NA | chemical drug | NA | 7.60e-01 | 1.0e-02 | CCNG1,CDKN1A,FASN,GCK,SESN2,TAF1B,TGFB1 | NA |
| doxifluridine | NA | chemical drug | NA | 7.50e-01 | 1.0e-02 | CCNG1,CDKN1A,FAS,TP53INP1 | NA |
| FGF1 | -3.60e-01 | growth factor | NA | 7.50e-01 | 0.0e+00 | CCND1,CDKN1A,DIO3,DLL1,DUSP6,FZD1,GADD45G,GCLM,Irgm1,JUN,NFE2L2,NR4A2,ODC1,PXYLP1,SGMS1,SLC7A2,TCF7L2,TGFB1 | 374 (22) |
| calcimycin | NA | chemical reagent | NA | 7.40e-01 | 2.0e-02 | AMD1,ATF3,BCL2L11,DDIT4,HERPUD1,ID3,INHBA,JUN,ODC1,REN,SERPINE1 | NA |
| SCD | 2.10e-01 | enzyme | NA | 7.30e-01 | 0.0e+00 | ABHD5,ATF3,CEBPB,CPT1A,DHCR24,DIO3,FAS,FASN,HERPUD1,HMGCS1,IL1RN,INSIG2,JUN,LPIN1,PNPLA2,PPARD,PPARGC1A,PPARGC1B,PTK6,PTPN1,RDH16,SGPL1,SQLE,TGM1,THRB,XBP1 | 377 (20) |
| FBXW7 | -1.70e-01 | enzyme | NA | 7.30e-01 | 0.0e+00 | BCL2L11,CIDEC,DNAJA1,FDFT1,HSPH1,JUN,LDLR,NR3C1,PPARGC1A,RHOB,SERPINE1,SQLE,TGFB1 | 429 (19) |
| SPARC | -8.00e-02 | other | NA | 7.30e-01 | 0.0e+00 | BHLHE40,C17orf78,CHRNA2,CIART,CIDEC,CLDN1,FANCB,IFIT3,PER2,SERPINA7,SERPINE1,SLC34A2,STAT3,TGFB1,USP2 | 483 (25) |
| UCN-01 | NA | chemical drug | NA | 7.30e-01 | 0.0e+00 | BCL2L11,CCND1,CDKN1A,RB1,RHOB | 374 (21) |
| Rhox5 | 4.00e-01 | transcription regulator | NA | 7.30e-01 | 0.0e+00 | BACH2,Cd24a,IDH3A,KLF9,PPARGC1A,TFRC,UNC5C | NA |
| PIM1 | 1.30e-01 | kinase | NA | 7.30e-01 | 5.0e-02 | CCND2,CDKN1A,GNL3,ID2,OSCAR,PPARGC1A | NA |
| phenobarbital | NA | chemical drug | NA | 7.30e-01 | 2.0e-02 | CCND1,CDKN1A,CYP7A1,GADD45B,HNF1A,HNF4A,INSIG1,SULT1C3,TAT | NA |
| TFEB | 1.20e-01 | transcription regulator | NA | 7.20e-01 | 2.0e-02 | ATP6V1B2,AURKA,BCL3,CCND1,CDT1,FASN,IL33,JUN,MCM10,MCM8,NRBF2,ORC1,POLD3,PPARGC1A,PRKAG2,RAD17,RECQL4,RGS1,TMPO,VPS18,VRK1,WDHD1 | NA |
| CG | NA | complex | NA | 7.20e-01 | 0.0e+00 | ABTB2,ADAMTS1,ADCYAP1R1,ARHGAP6,BHLHE40,BHMT,BTG2,CCDC86,CCND1,CCND2,CDK19,CDKN1A,CEBPB,CREM,CYP17A1,CYP26A1,DUOX2,DUSP6,FAM110C,FAS,FKBP5,FZD1,GADD45B,GNA15,GREM2,GTF2E1,GYS1,HMGCS1,HSD17B2,Hsd3b4 (includes others),ID2,IFIT3,IL15RA,IL17RB,IL33,INHBA,ITPR1,JUN,LDLR,MAF,MCM10,NRIP1,Oasl2,ORC1,PFKFB3,PLXND1,RAPH1,SDC4,SQLE,STC1,TNS1,UGP2,VCAN,WNT4 | 499 (24) |
| HDL-cholesterol | NA | complex | NA | 7.10e-01 | 0.0e+00 | CEBPB,CREM,FDFT1,HMGCS1,HNRNPD,MSMO1,NUPR1,SQLE | NA |
| CHD4 | 2.10e-01 | enzyme | NA | 7.10e-01 | 0.0e+00 | CDKN1A,CHEK2,CLCF1,DUOX2,FAS,ID2,ID4,JUN,SOCS2,SQLE | 346 (14) |
| ARID3A | -9.00e-02 | transcription regulator | NA | 7.10e-01 | 2.0e-02 | AASS,AZIN1,BRWD1,CCNE1,FOXO1,PRKD3,TMPO,WDHD1 | NA |
| K+ | NA | chemical - endogenous mammalian | NA | 7.00e-01 | 0.0e+00 | ATF3,BCL2L11,CYP17A1,ITPR1,JUN,NR4A2,REN,SLC12A3 | 413 (23) |
| NKX2-3 | NA | transcription regulator | NA | 7.00e-01 | 0.0e+00 | ADAMTSL2,ALPL,ASNS,CBS/LOC102724560,CDKN1A,CMPK2,GBP2,GDF15,HELZ2,HSD17B2,PARP14,PARP9,PAWR,PIM3,PLD1,PLEKHA4,PSAT1,REEP1,RTP4,TNFAIP8L1,ZNFX1 | 69 (3) |
| actinomycin D | NA | biologic drug | NA | 7.00e-01 | 0.0e+00 | AGT,ARHGEF26,ASS1,BCL2L11,BIRC2,BIRC3,CCND1,CDKN1A,CERS6,DDIT4,DIO3,FAS,FASN,ID2,IRF1,JUN,LMNB1,MADD,MAT1A,PFKFB3,SERPINE1,TGFB1,THRB,UBE2D1 | 420 (22) |
| C5 | NA | cytokine | NA | 7.00e-01 | 0.0e+00 | ATF3,BCL6B,C5AR2,CCND1,CCNE1,GDF15,HIVEP1,MBL2,NFE2L2,PLK3,RGS3,SERPINE1,SLC25A15,TGFB1,TNFAIP3 | 413 (22) |
| 3,3’-diindolylmethane | NA | chemical drug | NA | 7.00e-01 | 0.0e+00 | ATF3,CCND1,CDKN1A,FAS,FASN,GDF15,MAP1LC3B,OAS2,PARP2 | 429 (23) |
| PTTG1 | -6.00e-02 | transcription regulator | NA | 6.90e-01 | 1.0e-02 | APEX1,CCND1,CDKN1A,CEBPB,EGF,NPRL3,PARP2,PINX1,RAD18 | NA |
| Salmonella enterica serotype abortus equi lipopolysaccharide | NA | chemical toxicant | NA | 6.90e-01 | 0.0e+00 | ABL2,ASNS,ATP1B1,BIRC3,CD274,GADD45B,ID2,IL15RA,INHBA,IRF1,NFKBIZ,NLRP3,NOCT,NR4A2,OSGIN1,PDSS1,PIM3,PLD1,PTTG1IP,RGS1,TMPO | 404 (13) |
| FTI-277 | NA | chemical reagent | NA | 6.90e-01 | 1.0e-02 | CCND1,RHOB,SERPINE1,TGFB1 | 495 (23) |
| KLF10 | 5.50e-01 | transcription regulator | NA | 6.90e-01 | 2.0e-02 | CCND1,CDKN1A,SERPINE1,TGFB1 | NA |
| THRB | -6.30e-01 | ligand-dependent nuclear receptor | NA | 6.90e-01 | 0.0e+00 | BCL3,BIRC3,BTG2,CCND1,CCND2,CCNE1,CLEC10A,CPT1A,CYP7A1,EGF,FASN,FZD1,JUN,KLF9,LDLR,NCOA4,NLRP3,NOX4,Oasl2,PER1,POR,PPP2CA,RIPK3,SERPINE1,TGFB1,THRB,WNT4 | 421 (24) |
| stattic | NA | chemical reagent | NA | 6.80e-01 | 2.0e-02 | CCND1,CD274,FAS,STAT3,TGFB1 | NA |
| mono-(2-ethylhexyl)phthalate | NA | chemical toxicant | NA | 6.80e-01 | 0.0e+00 | ACO2,ACSBG1,ADIPOR2,CCND2,CCNE1,CPT2,DDIT4,Esrra,FAS,FASN,GCK,GNPNAT1,IDH3A,LDLR,PHF7,PPARD,PPARGC1A,PPARGC1B,PPTC7,TCF7L2,WDR43 | 389 (20) |
| TBK1 | -1.50e-01 | kinase | NA | 6.70e-01 | 0.0e+00 | BACH1,CDKN1A,CMPK2,CXCL11,IFI44,IFIT3,IL15,IL15RA,INHBA,Mx2,NFKBIZ,Oas1b,OAS2,Oasl2,RSAD2,TSC22D1,ZC3H12A | 296 (15) |
| EBF1 | -5.00e-02 | transcription regulator | NA | 6.60e-01 | 0.0e+00 | CBLB,CD79B,CEBPB,FASN,FOXO1,GYS1,IRF1,MKNK1,MKNK2,PDE3B,PIK3R1,PPARGC1A,PPP1R3C,PRKAA1,PRKAG2,PTPN1,SOS1 | 518 (23) |
| RLN2 | NA | other | NA | 6.60e-01 | 2.0e-02 | EDNRB,NLRP3,PYCARD,TGFB1 | NA |
| methotrexate | NA | chemical drug | NA | 6.50e-01 | 0.0e+00 | ADIPOR2,ALDOA,AMACR,AMD1,ANKH,APEX1,ASS1,BTG2,CCND1,CCNG1,CDKN1A,CLDN2,CPT1A,CXCL11,CYP7A1,DLAT,FAS,FASN,HMGCS1,LPIN1,MAP2K6,NR3C1,NR4A2,PCYT1A,PPARD,SDS,TGFB1,TNFRSF11B,TP53INP1,ZFP36L1 | 427 (22) |
| bleomycin | NA | biologic drug | NA | 6.40e-01 | 0.0e+00 | ARG1,ARRDC3,ATF3,BHLHE40,CCND2,CD300LF,CDKN1A,CIART,FAS,FZD1,GDF15,KLF15,LMNB1,MAP1LC3B,MAP3K6,PPARGC1A,PPTC7,RTP4,SDC4,SERPINE1,SIRPA,SOCS2,STAT3,STOM,TGFB1,TINAGL1,VPS18 | 427 (19) |
| isobutylmethylxanthine | NA | chemical toxicant | NA | 6.40e-01 | 0.0e+00 | AGT,CCND1,CCNE1,CDKN1A,CEBPB,CIDEC,CREM,CYP17A1,DHRS3,ENC1,IFIT3,INHBA,JUN,PDE3B,PPARD,PPARGC1A,RB1,SERPINE1,SYK,TGFB1,ZC3H12A | 535 (24) |
| abemaciclib | NA | chemical drug | NA | 6.40e-01 | 0.0e+00 | ABHD15,AGT,GDF15,LAMA3,LAMC1,PLXNB1 | NA |
| isoprenaline | NA | chemical drug | NA | 6.40e-01 | 1.0e-02 | EPHX2,LGALSL,MAP1LC3B,NR4A2,PER1,PNPLA2,TGFB1 | NA |
| epinephrine | NA | chemical - endogenous mammalian | NA | 6.40e-01 | 1.0e-02 | ADRA1B,CCND1,CCNE1,CDKN1A,IL33,PER1,POLA1,PPARGC1A,TFRC | NA |
| 5-O-mycolyl-beta-araf-(1->2)-5-O-mycolyl-alpha-araf-(1->1’)-glycerol | NA | chemical - endogenous non-mammalian | NA | 6.30e-01 | 0.0e+00 | ATF3,BCL3,CXCL11,GPAT3,IFIT3,NFKBIZ,RGS1,RND3,SDC4,TNFAIP3 | 281 (11) |
| SOX10 | -1.90e-01 | transcription regulator | NA | 6.20e-01 | 2.0e-02 | CD274,CDKN1A,CNTF,EDNRB,IRF1,RB1 | NA |
| butylated hydroxyanisol | NA | chemical toxicant | NA | 6.20e-01 | 2.0e-02 | GSTM4,HNF1A,IRF1,JUN,NFE2L2 | NA |
| NFKB1 | -4.00e-02 | transcription regulator | NA | 6.20e-01 | 1.0e-02 | ARG1,BCL3,BHLHE40,BIRC3,BTG2,CCND1,CCND2,CD274,CDKN1A,CXCL11,DLL4,FAS,FSCN1,IL1RN,IRF1,ITPR1,NR4A2,PLK3,RGS1,RIPK3,SDC4,TGFB1,TK1,TNFAIP3 | 412 (16) |
| L-glutamic acid | NA | chemical - endogenous mammalian | NA | 6.10e-01 | 0.0e+00 | ASL,BCL2L11,CCND1,CCNE1,CDKN1A,CIDEC,CLDN1,CYP7A1,DHCR24,FASN,FDFT1,GADD45B,HMGCS1,INSIG1,JUN,Kcnn2,MSMO1,PER1,PLA2G4A,PPARGC1A,SQLE,TOR3A | 438 (25) |
| gemfibrozil | NA | chemical drug | NA | 6.10e-01 | 0.0e+00 | CCND1,CPT1A,CPT2,LDLR,MOG,NR2C1,PCSK9,POR,PPARD,SERPINE1 | 424 (24) |
| Pka | NA | complex | NA | 6.10e-01 | 1.0e-02 | CDKN1A,CEBPB,CNTF,CREM,FOXA2,HNF4A,IRF1,JUN,LDLR,NR4A2,PLD1,PPARGC1A,REN,TNFRSF11B | 301 (19) |
| WNT4 | 1.88e+00 | cytokine | NA | 6.00e-01 | 4.0e-02 | CCND1,CYP17A1,FKBP5,FOXO1,PAX8,TGFB1 | NA |
| mir-133 | NA | microRNA | NA | 5.90e-01 | 4.0e-02 | CCND2,ELAVL1,FSCN1,HAND2,KLF15,PITPNB,VCAN | NA |
| oleic acid | NA | chemical - endogenous mammalian | NA | 5.90e-01 | 0.0e+00 | ARG1,ATF3,CEBPB,CERS6,CPT2,FASN,GADD45B,GDF15,LDLR,MAP1LC3B,PIK3IP1,PLIN4,PLIN5,PNPLA2,PPARGC1A,PRKAA1,REN,SERPINE1,XBP1 | 402 (23) |
| MK2206 | NA | chemical drug | NA | 5.80e-01 | 4.0e-02 | BCL2L11,CCND1,CD274,FOXO1,PFKFB3 | NA |
| NAE1 | 7.00e-02 | enzyme | NA | 5.80e-01 | 0.0e+00 | AURKA,CCND1,CDKN1A,RB1 | 314 (13) |
| CDK6 | -1.40e-01 | kinase | NA | 5.80e-01 | 0.0e+00 | AGT,ATP6V1B2,BIRC3,CACNB4,FGF11,HNRNPD,INHBA,ITPR1,JUN,MAP2K6,NFKBIZ,SERPINE1 | 411 (20) |
| thapsigargin | NA | chemical toxicant | NA | 5.80e-01 | 0.0e+00 | ADIPOR2,ASNS,ATF3,BIRC2,BIRC3,CAPN10,CCND1,CDKN1A,CEBPB,CPT1A,CREB3L2,CREM,DDIT4,EDEM1,GADD45B,GDF15,HERPUD1,INSIG1,JUN,LPIN1,LRIG1,NFE2L2,PAWR,PPP2CA,SESN2,XBP1 | 378 (21) |
| TCF4 | -1.20e-01 | transcription regulator | NA | 5.70e-01 | 4.0e-02 | BACH2,BHLHE40,CCDC117,CDKN1A,CREB3L2,CREM,CSF3R,EDEM1,FAS,FOXO1,GNE,GPR37,ID2,ID3,IL15,INHBA,NIFK,PPIF,QTRT2,RCBTB2,SEC24D,TMEM140,VSIR,XBP1 | NA |
| miR-503-5p (miRNAs w/seed AGCAGCG) | NA | mature microRNA | NA | 5.60e-01 | 0.0e+00 | CCND1,CCNE1,CCNF,CDC14A,CDKN1A,IHH,WEE1 | 133 (7) |
| NLRP3 | -6.10e-01 | other | NA | 5.60e-01 | 2.0e-02 | ARG1,CD274,DDB2,FAS,IFIT3,IL33,IRF1,NFE2L2,NLRP3,PARP2,PPME1,STAT3,TGFB1 | NA |
| indican | NA | chemical - endogenous mammalian | NA | 5.60e-01 | 0.0e+00 | AGT,CDKN1A,NFE2L2,NOX4,REN,TGFB1 | 368 (23) |
| SMAD1 | -1.60e-01 | transcription regulator | NA | 5.60e-01 | 0.0e+00 | ALPL,BTG2,CDKN1A,GADD45B,HHEX,ID4,IRF1 | 271 (7) |
| thalidomide | NA | chemical drug | NA | 5.60e-01 | 1.0e-02 | BIRC3,GADD45B,GDF15,NRP2,SERPINE1,TGFB1 | 448 (20) |
| FUS-DDIT3 | NA | fusion gene/product | NA | 5.60e-01 | 1.0e-02 | ASNS,IL6R,PALLD,SERPINE1,SOCS2,STAT3 | NA |
| PTGS1 | -1.20e-01 | enzyme | NA | 5.60e-01 | 1.0e-02 | ARG1,ATF3,CEBPB,PLA2G4A,PTGER3,STC1 | NA |
| CA9 | 1.40e-01 | enzyme | NA | 5.60e-01 | 2.0e-02 | ALDOA,CA12,COX10,SLC1A4,SLC3A2 | NA |
| NPY | -4.00e-02 | other | NA | 5.50e-01 | 0.0e+00 | CBS/LOC102724560,CYP7A1,FAS,FKBP5,LPIN1,NR3C1,PER1,PER2,PNPLA2,PPARGC1A,TOR3A | 460 (26) |
| N-acetyl-L-cysteine | NA | chemical drug | NA | 5.40e-01 | 0.0e+00 | BACH1,BCL2L11,BIRC2,BIRC3,CCND1,CCND2,CD274,CDKN1A,DDIT4,DUSP6,FAS,FASN,GCK,GCLM,GNL3,IL15,JUN,MAP1LC3B,NFE2L2,NFKBIZ,NLRP3,OSGIN1,PPARGC1A,PYCARD,RHOB,SERPINE1,TGFB1,TLR6 | 449 (21) |
| GAST | NA | other | NA | 5.40e-01 | 1.0e-02 | CCND1,CREM,DLAT,DNAJA1,HERPUD1,JUN,ODC1,PIK3R1,POR,STAT3 | 482 (28) |
| CDK19 | 9.60e-01 | kinase | NA | 5.40e-01 | 0.0e+00 | ATF3,BAIAP2,BTG2,CCND2,CCNG1,CDKN1A,DDB2,DDIT4,FAS,FDFT1,HMGCS1,JUN,OSGIN1,PLK3,RB1,STOM,TGFB1,TSC22D1,ZFP36L1 | 212 (7) |
| tretinoin | NA | chemical drug | NA | 5.40e-01 | 0.0e+00 | ABHD5,ADCYAP1R1,AGT,ALPL,APEX1,ARG1,ARHGAP29,ASNS,ATF3,ATOH8,ATP2B2,ATP6V1B2,AURKA,B3GALT1,BACH2,BCL3,BHLHE40,BHMT,BIRC2,BIRC3,BTG2,CBS/LOC102724560,CCND1,CCND2,CCNE1,CCNG1,CD101,CD274,CDKN1A,CEBPB,CERS3,CHKA,CLDN1,CPT1A,CRAT,CREM,CSF3R,CYP17A1,CYP26A1,CYP7A1,DACT2,DDB2,DHRS3,DIO3,DLL1,DLL4,DYNLL1,ETV6,FASN,FGR,FOXA1,FOXO1,GCK,GDF15,HNF1A,HNF4A,HNRNPD,ID2,ID3,IFI44,IFI44L,IFIT3,IL15,IL6R,INHBA,IRF1,ISLR,JUN,KLF15,KLF9,LRP2,LYN,MAFB,MAP3K5,MAPK6,MEIOB,MEIS2,MSI1,MSLN,NAT2,NDUFAF4,NFE2L2,NR2C1,NR3C1,NRIP1,OAS2,ODC1,OSCAR,PALLD,PARP14,PARP9,PCYT1A,PIK3R1,PKP2,PLD1,PLK3,POR,PPARD,PPARGC1A,PPP2CA,RARRES1,RB1,RCBTB2,REN,ROR1,RTP4,SEMA6B,SERPINB8,SERPINB9,SERPINE1,SIRPA,SLC17A9,SLC25A15,SLC26A3,SLC38A2,SLC7A2,SMOX,SOX5,SOX6,STAT3,STC1,SYCP3,TAT,TFRC,TGFB1,TGM1,TK1,TNFAIP3,TNFRSF11B,VMP1,WDR3,XBP1,ZNF703 | 441 (20) |
| estradiol-17beta-benzoate | NA | chemical reagent | NA | 5.40e-01 | 2.0e-02 | CCND1,CCNE1,CLDN2,INF2,ISLR,NECTIN1,NET1,NR4A2,PCDH20,PCSK6,PIM3,SPSB1,STC1,TGFB1,TNFRSF11B,UNC5B,WNT4 | NA |
| SMAD7 | -3.70e-01 | transcription regulator | NA | 5.30e-01 | 2.0e-02 | BCL2L11,BIRC2,CCNE1,CDKN1A,CGREF1,FAS,FOXA2,FOXO1,ID2,ID3,NET1,SERPINE1,TGFB1 | NA |
| BRD7 | NA | transcription regulator | NA | 5.20e-01 | 0.0e+00 | CCNG1,CDKN1A,FASN,PYCARD,SERPINE1,VCAN | 427 (22) |
| TNFAIP3 | 7.90e-01 | enzyme | NA | 5.20e-01 | 0.0e+00 | BIRC3,FAS,MAP3K5,NLRP3,SLC3A2,TFRC,TGFB1,TNFAIP3 | 353 (18) |
| RBL2 | 2.20e-01 | other | NA | 5.20e-01 | 0.0e+00 | AURKA,BCL2L11,CCND1,CCNE1,CCNF,CDKN1A,CDT1,CHKA,FAS,KPNA2,MAP3K14,RB1 | 392 (21) |
| nitric oxide | NA | chemical - endogenous mammalian | NA | 5.20e-01 | 0.0e+00 | ATF3,BIRC2,CCND1,CCNG1,CDKN1A,DUSP6,FAS,GCLM,JUN,NFE2L2,NR3C1,ODC1,PPARGC1A,SLC16A4,TFRC,TK1 | 436 (21) |
| 2-deoxyglucose | NA | chemical drug | NA | 5.20e-01 | 1.0e-02 | BCL2L11,BIRC2,CCND1,CDKN1A,DDIT4,GOT1,IFIT3,JUN,KLRD1,ODC1 | NA |
| Creb | NA | group | NA | 5.10e-01 | 0.0e+00 | AASS,ABL2,ARG1,ATF3,CCND1,CDKN1A,CEBPB,CIDEC,CNTF,CPT1A,CREM,CYP17A1,EDAR,Esrra,ETV5,FAS,FSCN1,GSTM4,IL33,JUN,LDLR,LMO4,NR3C1,NR4A2,NRN1,PDE3B,PER1,PER2,POLA1,PPARGC1A,PPP2CA,TNFRSF11B,TRIM6-TRIM34,UBC | 388 (21) |
| MYF6 | NA | transcription regulator | NA | 5.10e-01 | 0.0e+00 | CDKN1A,CNTF,DLL1,EGF,IL15,IL1RN,IL33,INHBA,SERPINE1,TGFB1,TNFRSF11B,TNFRSF14 | NA |
| benzo(a)pyrene | NA | chemical toxicant | NA | 5.10e-01 | 0.0e+00 | BCL2L11,CDK2AP2,CDKN1A,Chn1,FASN,FZD1,GCLM,GNA14,HDAC2,INHBA,ITPR1,JUN,LIMK2,MAF,MAP2K6,PDSS1,PPCS,PPIF,PPP1R3C,SELENBP1,SERPINE1,SLC1A4,TGFB1 | 361 (17) |
| paricalcitol | NA | chemical drug | NA | 5.10e-01 | 1.0e-02 | AGT,NLRP3,PYCARD,REN,TGFB1,TRPV6 | NA |
| INCB054329 | NA | chemical drug | NA | 5.10e-01 | 0.0e+00 | CCND1,CCND2,IL6R,STAT3 | 200 (7) |
| CLOCK | 9.00e-02 | transcription regulator | NA | 5.00e-01 | 0.0e+00 | BHLHE40,CA1,CCND1,CEMIP,CHST3,CYP26A1,DBP,DTX4,EEF2K,FABP7,FASN,FKBP5,GADD45B,GCK,GTF2E1,HSPH1,IHH,JAM3,KANK2,LPIN1,MID1IP1,MKNK2,MSMO1,NCOA4,NOCT,NOLC1,NR2C1,PER1,PER2,POR,PPIF,PRELID3B,SLC12A3,SMARCD2,ST3GAL5,TBRG4,TNFAIP1,USP2,WEE1 | 42 (2) |
| NFkB (complex) | NA | complex | NA | 5.00e-01 | 0.0e+00 | AGT,ATF3,BCL3,BIRC2,BIRC3,CARD10,CCND1,CCND2,Cd24a,CD274,CDKN1A,CEBPB,CGREF1,CITED4,CLCF1,CNTF,CREM,CXCL11,DBP,DBT,EDNRB,EFNA1,ELL2,FAS,GADD45B,GBP2,GDF15,HIF3A,HIVEP1,HNF4A,IL15,IL15RA,IL1RN,IRF1,ITPR1,JUN,MBL2,MTSS1,NFKBIZ,NLRP12,NOP14,ODC1,PIM3,PLD1,PLK3,PPIF,RSAD2,SDC4,SERPINE1,SLC7A5,SOX5,TDO2,TFRC,TGFB1,TNFAIP3,TNFRSF11B,ZC3H12A | 399 (14) |
| 25-hydroxycholesterol | NA | chemical reagent | NA | 5.00e-01 | 0.0e+00 | ASNS,ATF3,CCND1,CYP7A1,FASN,FDFT1,HMGCS1,INSIG1,JUN,LDLR,NR4A2,ODC1 | 239 (16) |
| androgen | NA | chemical drug | NA | 4.90e-01 | 2.0e-02 | ARHGEF26,BTG2,CA12,CCND1,DHCR24,FGFR2,IHH,INHBA,JUN,PIK3R1,PTPN1,SDC4,STAT3,VMP1 | NA |
| CCNC | 2.30e-01 | other | NA | 4.90e-01 | 1.0e-02 | CPT2,FAS,FASN,PNPLA2,PPARGC1A | 208 (7) |
| miR-26a-5p (and other miRNAs w/seed UCAAGUA) | NA | mature microRNA | NA | 4.90e-01 | 1.0e-02 | CCND2,CCNE1,CDKN1A,CHORDC1,RB1 | NA |
| ASAH1 | -1.10e-01 | enzyme | NA | 4.90e-01 | 3.0e-02 | CERS3,CERS6,CYP17A1,NR4A2,TGFB1 | NA |
| tunicamycin | NA | chemical - endogenous non-mammalian | NA | 4.90e-01 | 0.0e+00 | ADCYAP1R1,ADIPOR2,ASNS,ATF3,BIRC2,BIRC3,CCND1,CDKN1A,CEBPB,CPT1A,CPT2,CREB3L2,DDIT4,EDEM1,FASN,FITM2,GADD45B,HERPUD1,IFRD1,IHH,LPIN1,MFSD2A,PAX8,SEC22B,SEC24D,SESN2,XBP1 | 376 (23) |
| EGR2 | 3.80e-01 | transcription regulator | NA | 4.80e-01 | 0.0e+00 | ABHD5,ARHGAP24,ASS1,ATF3,BCL2L11,BHLHE40,CBLB,CDKN1A,CEBPB,CHKA,CISH,DEXI,DOK2,EPHA4,HMGCS1,ID2,ID3,ID4,IL21R,IL6R,JUN,LYSMD2,NECTIN1,NRP2,PDE7A,PPL,PPP2CA,SPECC1,SQLE,TFRC,TSC22D1 | 449 (22) |
| crizotinib | NA | chemical drug | NA | 4.80e-01 | 0.0e+00 | BCL2L11,CD274,FASN,PPARGC1A,PTP4A1,SERPINE1,VCAN | 436 (22) |
| conjugated linoleic acid | NA | chemical drug | NA | 4.80e-01 | 0.0e+00 | CBS/LOC102724560,GDF15,IL1RN,MAT1A,NLRP3,PPARGC1A,PPARGC1B,TNFAIP3,TNFRSF11B | 417 (18) |
| NUP62 | 3.10e-01 | transporter | NA | 4.70e-01 | 0.0e+00 | CDKN1A,EDAR,IHH,WWC1,ZNF750 | 257 (7) |
| captopril | NA | chemical drug | NA | 4.70e-01 | 0.0e+00 | AGT,ASNS,EPHX2,GTPBP4,IGFBP1,IL1RN,RBM3,REN,SLC34A2,TGFB1 | 319 (17) |
| methyl methanesulfonate | NA | chemical toxicant | NA | 4.60e-01 | 0.0e+00 | ATF3,BTG2,CCNG1,CDKN1A,DDB2,GADD45B,GADD45G,HERPUD1,JUN,NFYA,NUPR1,TP53INP1 | 401 (21) |
| SB-431542 | NA | chemical reagent | NA | 4.60e-01 | 0.0e+00 | CCND1,CYP17A1,DHCR24,FASN,GADD45B,HMGCS1,ID2,ID3,KCNJ8,Kcnn2,MAFB,SERPINE1,SPSB1,SQLE,STAT3,TFRC,TGFB1 | 518 (23) |
| MED1 | 2.60e-01 | transcription regulator | NA | 4.50e-01 | 0.0e+00 | AURKA,BCL3,BHLHE40,CCND1,CCND2,CCNE1,CCNJ,CD79B,CDKN1A,CYP17A1,CYP7A1,FASN,FOXO1,GCK,ID2,IGFBP1,NR3C1,ODC1,PEX11A,TRPV6,XBP1 | 418 (21) |
| MI-503 | NA | chemical reagent | NA | 4.50e-01 | 0.0e+00 | CBS/LOC102724560,CCND2,DDIT4,FGF11,TGFB1 | NA |
| acetaldehyde | NA | chemical - endogenous mammalian | NA | 4.50e-01 | 0.0e+00 | CEBPB,JUN,KLF9,SMOX,TGFB1 | 363 (18) |
| lipoxin A4 | NA | chemical - endogenous mammalian | NA | 4.50e-01 | 2.0e-02 | CCND1,CDKN1A,LIMK2,NLRP3,SERPINE1,TGFB1 | NA |
| DDX3X | NA | enzyme | NA | 4.50e-01 | 2.0e-02 | CCND1,CDKN1A,MAPK11,ODC1,XBP1 | NA |
| NLRP12 | -5.90e-01 | other | NA | 4.50e-01 | 2.0e-02 | BCL3,IL1RN,JUN,MAP3K14,NR3C1 | NA |
| NSUN6 | -5.90e-01 | enzyme | NA | 4.50e-01 | 3.0e-02 | ETV5,FSCN1,SERPINE1,TK1,TNS1 | NA |
| OMA1 | -1.00e-01 | peptidase | NA | 4.50e-01 | 3.0e-02 | ASNS,FASN,GDF15,PPARGC1A,PPARGC1B | NA |
| Z-LLL-CHO | NA | chemical - protease inhibitor | NA | 4.50e-01 | 0.0e+00 | ATF3,AURKA,BCL2L11,BIRC3,CBS/LOC102724560,CCND1,CCND2,CCNG1,CDKN1A,CDT1,CEBPB,CISH,DDB2,ELAVL1,ETV5,FAS,FASN,FOXO1,HNF1A,JUN,MAPK6,MCM10,NFE2L2,NOX4,NR1I2,NR3C1,ODC1,PFKFB3,PLK3,RB1,RGS7,SLC12A3,TNK2 | 432 (21) |
| Wy 40905 | NA | chemical reagent | NA | 4.40e-01 | 0.0e+00 | ATF3,BTG2,CDKN1A,CREM,GADD45B,JUN,NFKBIZ,PER1,SERPINB9,SERPINE1 | 433 (25) |
| Ige | NA | complex | NA | 4.40e-01 | 0.0e+00 | ARG1,BAIAP2,BCL2L11,BCL3,CCND2,CDK19,CDKN1A,CISH,CLCF1,CMPK2,DUSP6,ETV5,FAS,GADD45B,GDF15,HIP1R,IL15,IL33,MAPKAPK3,NXPE4,PIK3IP1,PLK3,PPIF,RSAD2,Serpinb6b,TFRC,TGFB1,TNFRSF11B,TPST2,VMP1 | 400 (16) |
| PRDM1 | 4.20e-01 | transcription regulator | NA | 4.40e-01 | 0.0e+00 | ALPL,BCL2L11,CLDN1,DDIT4,FGR,GPAT3,HHEX,ID2,ID3,IFIT3,IRF2BP2,ITPR1,LIMK2,MAF,MAFB,MAP3K5,MAPK11,MTMR11,NLRP12,NLRP3,OAS2,PCSK6,PLA2G4A,RSAD2,SOCS2,TNFRSF14,XBP1 | 445 (22) |
| TGFA | 3.20e-01 | growth factor | NA | 4.40e-01 | 1.0e-02 | BIRC3,CCND1,CDKN1A,CEBPB,NR4A2,PLA2G4A,RB1,SERPINE1,TGFB1 | NA |
| EGLN1 | 1.20e-01 | enzyme | NA | 4.40e-01 | 1.0e-02 | AURKA,CNTF,DLL1,IL1RL2,INHBA,SDC4,TGFB1,TNFRSF11B | NA |
| SP1 | -5.00e-02 | transcription regulator | NA | 4.30e-01 | 0.0e+00 | ADAMTS1,ADRA1B,ALPL,ANKH,ASNS,ASS1,ATF3,CBS/LOC102724560,CCND1,CCND2,CD79B,CDKN1A,CEBPB,CIRBP,CREM,CYP17A1,CYP26A1,DDB2,DHCR24,DLAT,FAS,FASN,GDF15,GOT1,HDAC2,HNF4A,ID4,IGFBP1,IL15,IL21R,IRF1,ITPR1,JUN,LDLR,MEOX2,NOX4,PCYT1A,PLA2G4A,PPARD,PTPN1,RB1,RECQL4,SERPINE1,STAT3,TGFB1,TGM1,THRB,TNFAIP3,UBC,UGDH | 455 (22) |
| vancomycin | NA | biologic drug | NA | 4.30e-01 | 0.0e+00 | AASS,ADAMTS1,ASNS,BACH1,BIRC3,CCND1,CMPK2,Ctla2a,GTPBP4,IGFBP1,MYO1B,NOX4,NRIP1,RBM3,SEC22B,SLC34A2,SOCS2,ST3GAL6,STAT3,USP2 | 292 (7) |
| enalapril | NA | biologic drug | NA | 4.30e-01 | 2.0e-02 | ADAMTS1,AGT,ASNS,GTPBP4,IGFBP1,REN,SERPINE1,SLC34A2,TGFB1 | NA |
| homocysteine | NA | chemical - endogenous mammalian | NA | 4.30e-01 | 3.0e-02 | ASNS,ATF3,BHMT,CCND1,CDKN1A,CRAT,FASN,HERPUD1,MSMO1,XBP1 | NA |
| Bay 11-7082 | NA | chemical - kinase inhibitor | NA | 4.30e-01 | 3.0e-02 | CCND1,CD274,ELAVL1,IL15,IL15RA,IL17RB,NFKBIZ,NLRP3,PYCARD | NA |
| RAF1 | -2.70e-01 | kinase | NA | 4.20e-01 | 0.0e+00 | AMD1,BCL2L11,CCND1,CDKN1A,CLDN1,DHRS3,DUSP6,FAS,ID3,JUN,LAMA3,MCM8,NOP56,PCSK6,PLD1,RGS1,RND3,SELENBP1,SQLE,TOMM40,TSC22D1 | 390 (25) |
| allopurinol | NA | chemical drug | NA | 4.20e-01 | 1.0e-02 | ADAMTS1,ASNS,BIRC3,Ctla2a,GTPBP4,IGFBP1,RBM3,REN,SLC34A2,TLR6 | NA |
| MTORC1 | NA | complex | NA | 4.20e-01 | 0.0e+00 | CCND1,CYP17A1,FASN,INSIG1,MOG,NOX4,ODC1,PPARGC1A | 397 (20) |
| HNRNPK | 3.40e-01 | other | NA | 4.20e-01 | 0.0e+00 | AGT,CDKN1A,LDLR,LPIN1,NFE2L2,NRXN2,RB1,VCAN | 291 (11) |
| CTLA4 | -1.40e-01 | transmembrane receptor | NA | 4.20e-01 | 4.0e-02 | CBLB,KPNA2,PRKD3,RAB30,SLC7A5,TGFB1,ZFP57 | NA |
| EGR3 | -2.00e-02 | transcription regulator | NA | 4.10e-01 | 0.0e+00 | ABHD5,ARHGAP24,ATF3,BHLHE40,CBLB,CISH,DEXI,DOK2,ID3,IL21R,IL6R,INSC,JUN,LYSMD2,NECTIN1,NRP2,PLXND1,PPL,SPECC1,TSC22D1 | NA |
| DETA-NONOate | NA | chemical reagent | NA | 4.10e-01 | 0.0e+00 | BIRC2,BIRC3,CCND1,CDKN1A,FAS,ODC1,PDE3B,SERPINE1,TNFRSF11B | 386 (19) |
| E. coli B5 lipopolysaccharide | NA | chemical - endogenous non-mammalian | NA | 4.10e-01 | 0.0e+00 | ADAMTS1,AKR1C4,BCL3,BHLHE40,BHMT,BIRC2,BIRC3,CCND1,CD274,CDKN1A,CLDN14,CSF3R,CYP7A1,FASN,GBP2,GCLM,GNPNAT1,IGFBP1,Igtp,IL15,IL15RA,IL21R,IL6R,IRF1,LDLR,MAT1A,PAH,PPARGC1A,RHOB,SELENBP1,SEPHS2,SERPINE1,SLCO1B3,SOCS2,STAT3,TAT,TGFB1,TLR6,TNFAIP3 | 417 (17) |
| NR5A2 | 1.40e-01 | ligand-dependent nuclear receptor | NA | 4.10e-01 | 0.0e+00 | BAAT,CCND1,CDKN1A,CEBPB,CYP17A1,CYP7A1,FASN,FOXA2,GADD45G,GOT1,HNF1A,HNF4A,IGFBP1,IL1RN,JUN,LDLR,NR1I2,ONECUT1,PLK3,TGFB1 | 437 (25) |
| MAPK14 | 1.00e-02 | kinase | NA | 4.10e-01 | 1.0e-02 | ATF3,BTG2,CCND1,CYP7A1,DLL1,DUSP6,EFNA1,ELAVL1,FAS,FASN,HAND2,JUN,LDLR,MAP2K6,MAPK11,PPARGC1A,PPARGC1B,RGS1,TGFB1 | 480 (26) |
| reactive oxygen species | NA | chemical toxicant | NA | 4.10e-01 | 3.0e-02 | APEX1,CDKN1A,FAS,GCK,JUN,LPIN1,NFE2L2,SERPINE1,TGFB1,TNFAIP3,XBP1 | NA |
| PRKAA1 | 7.80e-01 | kinase | NA | 4.10e-01 | 0.0e+00 | ARG1,ATF3,BIRC3,CDKN1A,EGF,FGFR2,FKBP5,HIGD1A,ID2,IFI44,Ifi47,IL17RB,LMO4,PPARGC1A,RND3,SOS1,TNS1,ZFP36L1 | 389 (22) |
| OSM | 2.20e-01 | cytokine | NA | 4.00e-01 | 0.0e+00 | ADAMTS1,AMACR,ARG1,ARL4A,ASNS,ATF3,BAIAP2,BCL2L11,BCL3,BHLHE40,CCND1,CCND2,CDKN1A,CISH,CLPX,DHCR24,DHRS3,DNAH17,FASN,GADD45G,GART,GBP2,ID2,IL15,IL15RA,IL33,IL6R,IRF1,JUN,LDLR,MAP2K6,MKNK2,MX1,NRIP1,P2RY10,PFKFB2,PFKFB3,PLA2G4A,PREP,PTP4A1,RAD17,RASL11A,SERPINB8,SERPINE1,SLC16A6,SLC4A8,STAT3,SYNE1,TAT,TDO2,TNFRSF11B | 459 (21) |
| artepillin C | NA | chemical reagent | NA | 4.00e-01 | 0.0e+00 | FASN,HMGCS1,LDLR,PCSK9,PPARGC1A,PPARGC1B | 276 (17) |
| aflatoxin B1 | NA | chemical - endogenous non-mammalian | NA | 3.90e-01 | 0.0e+00 | ADAMTS7,CCNE1,CCNG1,Cd24a,CDKN1A,CLDN1,DBP,EDNRB,EGF,FAS,Gabpb1,GCLM,GDF15,GORAB,INHBA,LDLR,MCM8,NRCAM,PRMT2,PRRG4,PSAT1,RAD18,SERPINB9,SQLE,UGDH,WNT4 | 234 (7) |
| JUN/JUNB/JUND | NA | group | NA | 3.90e-01 | 1.0e-02 | IGFBP1,JUN,LGALS9B,PTPRO,STAT3 | NA |
| 9,10-dimethyl-1,2-benzanthracene | NA | chemical toxicant | NA | 3.90e-01 | 5.0e-02 | ARG1,CCND1,CDKN1A,EGF,JUN,SERPINE1 | NA |
| UCHL1 | -6.00e-02 | peptidase | NA | 3.90e-01 | 0.0e+00 | ADCY9,BACH2,CDKN1A,EIF2B3,LDLR,LPIN1,MAPK6,ORC1,PLA2G4A,RHOF,SERPINE1 | 270 (7) |
| selumetinib | NA | chemical drug | NA | 3.80e-01 | 0.0e+00 | ABL2,BCL2L11,CCND1,CD274,CDKN1A,EPHA4,FGFR2,FGR,JUN,LYN,PKDCC,PPARGC1A,SRMS | 376 (21) |
| miR-125b-5p (and other miRNAs w/seed CCCUGAG) | NA | mature microRNA | NA | 3.80e-01 | 1.0e-02 | ADAMTS1,ARG1,DIO3,ELAVL1,ID2,ID3,IL1RN,IL6R,JUN,SGPL1,VSIR | 453 (17) |
| dactolisib | NA | chemical drug | NA | 3.80e-01 | 3.0e-02 | BCL2L11,CDKN1A,DDIT4,GYS1,MAP1LC3B,P4HA1,STC1 | NA |
| S100A6 | -1.00e-01 | transporter | NA | 3.80e-01 | 0.0e+00 | ADAMTS1,ATF3,AURKA,INHBA,STC1,TMPO,TNFAIP3 | NA |
| daporinad | NA | chemical drug | NA | 3.80e-01 | 0.0e+00 | BHLHE40,CD274,CEBPB,LMNB1,LRIG1,MCM10,SERPINE1 | 313 (11) |
| PPRC1 | 3.40e-01 | transcription regulator | NA | 3.80e-01 | 0.0e+00 | CLDN1,DDIT4,GDF15,NFKBIZ,OSCAR,RND3,ZFP36L1 | NA |
| HIC1 | -5.20e-01 | transcription regulator | NA | 3.80e-01 | 2.0e-02 | CA12,CCND1,CDKN1A,ID4,INHBA,ITPR1,PLA2G4A | NA |
| INSIG1 | 1.89e+00 | other | NA | 3.60e-01 | 0.0e+00 | AACS,ATF3,DHCR24,FASN,FDFT1,HMGCS1,JUN,LDLR,LPIN1,NFE2L2,NFKBIZ,PLD1,SQLE,TGFB1 | 175 (10) |
| CDKN2A | NA | transcription regulator | NA | 3.60e-01 | 0.0e+00 | AMD1,ASNS,ASS1,BACH2,BCL2L11,BTG2,CCND1,CCNE1,CCNG1,CD274,CD79B,CDCA4,CDKN1A,CEBPB,EFNA1,Esrra,FAS,FASN,FGF11,FOXA1,GADD45G,GNL3,GOT1,IL15,IL6R,JUN,KANK2,MCM8,NOX4,NR3C1,ODC1,POLD3,PSAT1,RB1,RECQL4,SERPINE1,SH3BP2,TK1,TMPO,TP53INP1,UBR7,VRK1 | 399 (21) |
| FOS | 3.90e-01 | transcription regulator | NA | 3.60e-01 | 2.0e-02 | AGT,ASL,ATF3,BCL2L11,CCND1,CCNE1,CCNG1,CLDN2,CYP17A1,CYP7A1,EPHX2,FASN,FOXA1,IGFBP1,JUN,LAMA3,MAFK,MAPK6,MSLN,NET1,NFE2L2,NR3C1,NRIP1,NUPR1,ODC1,PLD1,PTP4A1,PTPRO,RPS18,SELENBP1,SERPINB9,SERPINE1,SIRPA,SMARCD2,TGFB1,TNFRSF11B,WEE1,WNT4 | NA |
| ARID1A | -1.70e-01 | transcription regulator | NA | 3.60e-01 | 1.0e-02 | AGL,ALPL,CD274,CDKN1A,DLL4,FOXA1,FSCN1,FZD1,GNA15,GYS1,MARS2,MIEF2,MSLN,P4HA1,PEX11A,PIK3IP1,PLXND1,RGP1,RNF144A,TCF7L2,WNT4 | 356 (16) |
| hemin | NA | chemical - endogenous mammalian | NA | 3.60e-01 | 4.0e-02 | CCND1,CDKN1A,IL33,JUN,NFE2L2,NFYA,NFYB,PTPN1,TGFB1 | NA |
| CDX2 | NA | transcription regulator | NA | 3.60e-01 | 2.0e-02 | CA1,CDKN1A,CLDN1,CLDN2,CYP26A1,DLL1,HNF4A,JUN,NLRP3,SH3PXD2A,SLC26A3,SOX5,TCF7L2,TGFB1 | NA |
| HIF1A | -1.30e-01 | transcription regulator | NA | 3.50e-01 | 0.0e+00 | ADAMTS1,AGT,ALDOA,ASNS,AURKA,BACH2,BCL6B,BHLHE40,BIRC2,CCND1,CD274,CDKN1A,CEMIP,CHKA,CLDN1,CTPS1,DDIT4,DLL4,EDNRA,EDNRB,FAS,FSCN1,GADD45B,GCK,HIF3A,ID2,IL15,INSIG2,ITPR1,JUN,KIFC2,MAF,NCOA4,NFKBIZ,NOX4,NRN1,NUCKS1,P4HA1,PER2,PFKFB3,PTK6,SDC4,SERPINE1,SESN2,SLC16A4,STAT3,TCF7L2,TFRC,TGFB1,TLR6,TNFRSF11B,ZNF608 | 387 (18) |
| TAF4 | NA | transcription regulator | NA | 3.50e-01 | 0.0e+00 | ABL2,CCND1,CLDN1,FOXA2,ID2,IL1RN,MAFK,MAP3K6,PPARGC1A,TGFB1,TGM1,WWC1 | 283 (12) |
| indole-3-carbinol | NA | chemical drug | NA | 3.50e-01 | 2.0e-02 | CCND1,CDKN1A,GDF15,NFE2L2,RB1 | NA |
| WWTR1 | 3.00e-02 | transcription regulator | NA | 3.50e-01 | 3.0e-02 | CCND1,CDKN1A,CYP17A1,FASN,FOXA1,ID2,INHBA,LAMA3,MX1,PLIN4,SERPINE1,TK1 | NA |
| TNFSF10 | -5.60e-01 | cytokine | NA | 3.40e-01 | 2.0e-02 | BIRC2,BIRC3,CD274,DDIT4,IL17RB,IL1RN,JUN,PER1,PIK3IP1,TFRC,TNFAIP3,TNK2 | NA |
| ATG5 | NA | other | NA | 3.40e-01 | 2.0e-02 | AGT,ARG1,BCL2L11,CLEC10A,DYNLL1,MAP2K6,NFE2L2,PPP2R2B,TOMM40 | NA |
| 8-bromo-cAMP | NA | chemical reagent | NA | 3.40e-01 | 0.0e+00 | ARG1,ASS1,BIRC3,CCND1,CCND2,CDKN1A,CEBPB,CREM,CSF3R,CYP17A1,DDB2,DLL4,ENC1,FAS,FOXO1,HDAC2,ID2,ID3,ID4,IGFBP1,IL15,INHBA,ITGA9,JUN,LDLR,NFYA,NFYB,NPC1,ODC1,P4HA1,PDE3B,PIK3R1,PPARD,PPARGC1A,PPL,PTGER3,REN,SERPINE1,STAT3,TGFB1,WEE1,WNT4 | 507 (24) |
| BACH2 | 2.01e+00 | transcription regulator | NA | 3.30e-01 | 0.0e+00 | ETV5,FOXO1,ID3,JUN,LAMC1,MAF,MAFB,PDE3B,XBP1 | 394 (16) |
| MYO6 | 1.00e-02 | other | NA | 3.30e-01 | 1.0e-02 | ATF3,BACH2,DUSP6,KLF9,LPIN1,NFKBIZ,RHOB,SDC4,TNK2 | NA |
| IGFBP5 | -2.90e-01 | other | NA | 3.30e-01 | 1.0e-02 | BHLHE40,CCND1,LAMC1,PFKFB3,SERPINE1 | 412 (21) |
| DUSP1 | -5.60e-01 | phosphatase | NA | 3.30e-01 | 0.0e+00 | AACS,CIDEC,CLEC10A,CMPK2,CYP17A1,DUSP6,GDF15,HELZ2,IFI44,IFIT3,IL1RN,IRF1,JUN,MX1,Mx2,PEX11A,PIK3R1,RSAD2,RTP4,SERPINE1,SPRYD7 | 409 (19) |
| fatty acid | NA | chemical - endogenous mammalian | NA | 3.20e-01 | 0.0e+00 | CREM,CYP7A1,FAS,FASN,GCK,LDLR,NR4A2,PLIN4,PLIN5,PPARD,PPARGC1A,PRKAA1,SERPINE1,ST3GAL5 | 425 (19) |
| KLF5 | -1.80e-01 | transcription regulator | NA | 3.20e-01 | 0.0e+00 | ARG1,CCND1,CDKN1A,CDT1,CGREF1,CITED4,FOXA1,HHEX,ID3,JUN,MEOX2,NFKBIZ,PPARD,TBC1D14,TRPV6,ZFP36L1 | 435 (24) |
| TP63 | 3.00e-02 | transcription regulator | NA | 3.20e-01 | 0.0e+00 | ADAMTS1,ARG1,BCL2L11,BCL3,BHLHE40,CCND1,CCND2,CCNE1,CCNG1,CDKN1A,CLDN3,CPT2,DDB2,DDIT4,DLL1,DUSP6,FAS,FASN,FGF11,FGFR2,FOXA2,FSCN1,HIP1R,ID3,IHH,INHBA,JUN,LAMA3,LIMK2,LYN,MCM10,PKP2,PPARGC1A,PPP2CA,PRKAG2,RASL11A,RASSF3,S1PR1,SERPINE1,SESN2,TCF7L2,TGFB1,TINAGL1,TP53INP1,VMP1,WEE1,WNT4,ZNF750 | 382 (17) |
| glutamine | NA | chemical - endogenous mammalian | NA | 3.20e-01 | 0.0e+00 | ASNS,ASS1,BCL2L11,CCND1,CD274,CDKN1A,CEBPB,DDIT4,IL15,JUN,NUP98,PPARGC1A,TIMM17A,XBP1 | 531 (23) |
| diethylstilbestrol | NA | chemical drug | NA | 3.10e-01 | 4.0e-02 | ADCYAP1R1,ALPL,Aox3,CCND1,CDKN1A,CYP17A1,DUSP6,EGF,Esrra,FAS,INHBA,LMO4,MAFB,NR3C1,PTTG1IP,REN,RNF4,SOCS2,TGFB1,Tlr12,WNT4 | NA |
| pregnenolone carbonitrile | NA | chemical drug | NA | 3.00e-01 | 1.0e-02 | CPT1A,CYP7A1,INSIG1,NR1I2,SLCO1B3,SULT1B1,TNFRSF14 | 408 (18) |
| KMT2D | 1.00e-02 | transcription regulator | NA | 3.00e-01 | 1.0e-02 | Acot1,ADGRG2,ASL,CD274,FAM117A,IRF1,IRF6,PPP1R26,PPP2R2B,PRR15,RELL1,STBD1,TGM1,WDSUB1,ZNF184,ZNF23,ZNF750 | NA |
| carbonyl cyanide m-chlorophenyl hydrazone | NA | chemical toxicant | NA | 3.00e-01 | 0.0e+00 | AGT,CLDN1,DDIT4,GDF15,MAP1LC3B,NFKBIZ,NLRP3,OSCAR,RND3,SERPINE1,TGFB1,ZFP36L1 | 421 (24) |
| Nr1h | NA | group | NA | 3.00e-01 | 0.0e+00 | AGT,ATP1B1,BCL3,CCND2,CERS3,CPT2,CYP7A1,EDNRA,FASN,GCK,IL15,INSIG2,ITPR1,Mx2,NFKBIZ,NLRP3,NPC1,Oas1b,PPARGC1A,REN | 340 (24) |
| 3-deazaneplanocin | NA | chemical drug | NA | 3.00e-01 | 0.0e+00 | CD274,CDKN1A,CEBPB,FAS,FOXA1,MAP3K14,NOX4,NUPR1,PLXNB1,SLC7A2,TGFB1 | 440 (25) |
| FGF21 | -2.40e-01 | growth factor | NA | 3.00e-01 | 0.0e+00 | ARG1,ASNS,CCND1,CPT1A,FAS,FASN,FGFR2,IGFBP1,ITPR1,LDLR,PPARGC1A,PPARGC1B,SERPINE1,TGFB1,XBP1 | 395 (21) |
| TSH | NA | complex | NA | 2.90e-01 | 0.0e+00 | CCND1,CCNE1,CDKN1A,FOXO1,FZD1,IL1RN,NOX4,PAX8,PPARD | 414 (24) |
| FGFR2 | -8.70e-01 | kinase | NA | 2.90e-01 | 2.0e-02 | CCND1,CCND2,CD274,CDKN1A,CYP7A1,DLL1,FAS,FGFR2,FOXA2,ID2,IHH,TENM3 | NA |
| medroxyprogesterone acetate | NA | chemical drug | NA | 2.90e-01 | 0.0e+00 | ADAMTS1,ASS1,BCL2L11,BIRC3,BTG2,CCND1,CCND2,CDKN1A,CLDN1,CSF3R,DDB2,DLL4,ENC1,FAS,FASN,FOXO1,HDAC2,ID2,ID3,ID4,IGFBP1,IL15,IL6R,INHBA,ITGA9,JUN,NPC1,ODC1,P4HA1,PDE3B,PIK3R1,PPL,PTGER3,REEP1,SERPINE1,STAT3,TGFB1,VCAN,WEE1,WNT4 | 500 (22) |
| NR1I3 | -1.50e-01 | ligand-dependent nuclear receptor | NA | 2.90e-01 | 0.0e+00 | CDKN1A,CYP7A1,FASN,GADD45B,GSTM4,HNF4A,INSIG1,INSIG2,NR1I2,PDE3B,POR,RARRES1,SLCO1B3,SULT1C3 | 330 (10) |
| RARA | 7.00e-02 | ligand-dependent nuclear receptor | NA | 2.80e-01 | 0.0e+00 | AASS,CA12,CCND1,CDKN1A,CEBPB,COBL,CYP26A1,CYP7A1,DHRS3,ELL2,GCK,GDF15,HNRNPD,IFI44,IFI44L,IL6R,IRF1,IRF6,JUN,MAFB,NR2C1,PLXNA2,RARRES1,RGS3,RSAD2,RTP4,SLC17A9,TGFB1,TNFAIP8L1,TNFRSF11B,XBP1,ZNF703 | 423 (22) |
| TRAF2 | -2.90e-01 | enzyme | NA | 2.80e-01 | 0.0e+00 | AURKA,BIRC2,BIRC3,CHKA,EFNA1,FAS,PPARGC1A,PPFIBP2,TK1,TNFAIP3,WEE1 | 383 (20) |
| JINK1/2 | NA | group | NA | 2.80e-01 | 1.0e-02 | CYP7A1,FAS,FASN,FOXO1,RHOB | NA |
| calcitriol | NA | chemical drug | NA | 2.80e-01 | 0.0e+00 | ACKR4,ADCY9,AFAP1L2,ALPL,ARG1,BACH1,BCL3,BIRC2,CCND1,CCND2,CCNE1,CDKN1A,CDT1,CEBPB,CISH,CPT1A,CYP7A1,DACT2,DHCR24,DLL1,ETV5,FAS,FASN,FOXA2,GADD45G,GCK,HSD17B2,ID2,IFI44L,IL15,IL1RN,JUN,KCNH1,KPNA2,KSR2,LRTM2,MAF,MFSD2A,MSI1,MX1,NCAPD2,NOX4,NUPR1,ODC1,OSCAR,PALMD,PLD1,POR,PPARD,PPIF,RARRES1,RB1,REN,RNF144A,RSAD2,S1PR2,SARDH,SERPINB9,SLC34A2,SLC45A3,SNX24,SPON2,STAT3,STXBP6,TGFB1,TINAGL1,TK1,TNFAIP3,TNFRSF11B,TP53INP1,TRPV6,WEE1,ZNF608 | 425 (27) |
| CSF3 | 3.00e-02 | cytokine | NA | 2.80e-01 | 0.0e+00 | ARG1,BIRC3,CCND2,CCNE1,CD300LF,CEBPB,CISH,CSF3R,DUSP6,GADD45B,GADD45G,IL1RN,JUN,NCDN,ODC1,RGS1,STAT3,TFRC,TGFB1,TNFAIP3 | 420 (18) |
| kainic acid | NA | chemical toxicant | NA | 2.80e-01 | 0.0e+00 | ATF3,BTG2,CCND1,CCNE1,CEBPB,CIART,CNTF,CREM,EGF,FGFR2,GADD45B,JUN,NR3C1,NR4A2,ODC1,PER1,PIM3,PTGER3,TCF7L2 | 369 (21) |
| RARB | 2.40e-01 | ligand-dependent nuclear receptor | NA | 2.80e-01 | 0.0e+00 | BIRC2,CCNE1,CDKN1A,CYP26A1,DHRS3,GBP2,ID3,Ifi47,Igtp,Irgm1,JUN,PTGER3,SLC17A9,SLC26A3,TGFB1,TGM1,ZNF703 | 439 (26) |
| proteasome inhibitor PSI | NA | chemical - protease inhibitor | NA | 2.80e-01 | 1.0e-02 | FAS,MAPK6,MCM10,NFE2L2,SYK | NA |
| Laminin (complex) | NA | complex | NA | 2.80e-01 | 1.0e-02 | BIRC3,CCND1,ETV5,ID2,SDC4,SERPINE1 | NA |
| TXNRD1 | -2.30e-01 | enzyme | NA | 2.80e-01 | 5.0e-02 | FAS,GSTM4,LPIN1,UGDH,UGP2 | NA |
| topotecan | NA | chemical drug | NA | 2.70e-01 | 2.0e-02 | ARHGAP24,ASAP3,ATF3,AURKA,BCL3,BIRC3,CCNE1,CDKN1A,CREB3L2,FAS,GADD45B,GDF15,GSE1,HDAC2,IFIT3,IRF1,JUN,MBNL2,OAF,PLK3,RCBTB2,RDH13,SESN2,SLC7A5,TNFAIP3 | NA |
| NGFR | -4.50e-01 | transmembrane receptor | NA | 2.70e-01 | 0.0e+00 | CCND1,CCNE1,FGFR2,JUN,LDLR,RB1,RHOB,SERPINE1 | 433 (20) |
| KCNIP3 | -1.00e-02 | transcription regulator | NA | 2.70e-01 | 2.0e-02 | CCND1,CREM,EDEM1,IL17RB,LDLR,RABGEF1,SIRPA,TNFAIP3 | NA |
| TNFRSF1A | 1.80e-01 | transmembrane receptor | NA | 2.60e-01 | 0.0e+00 | BIRC3,CDKN1A,CEBPB,EFNA1,GCLM,IL15,JUN,LGALS9B,NFE2L2,PPARD,RGS7,SERPINE1,SOX6,TFRC,TGFB1,TNFAIP3 | 398 (16) |
| miR-92a-3p (and other miRNAs w/seed AUUGCAC) | NA | mature microRNA | NA | 2.60e-01 | 0.0e+00 | BCL2L11,CCND1,CCND2,CCNE1,CDKN1A,EDNRB,NOX4 | 360 (15) |
| THPO | NA | cytokine | NA | 2.60e-01 | 0.0e+00 | AURKA,BIRC3,CCND1,CCND2,CCNE1,CIAPIN1,CISH,CMPK2,FOXA2,HNF1A,INHBA,IRF1,NFE2L2,NFKBIZ,RSAD2,TNFAIP3 | 427 (27) |
| arotinoid acid | NA | chemical toxicant | NA | 2.50e-01 | 3.0e-02 | CDKN1A,ODC1,RARRES1,TK1 | NA |
| N-acetylsphingosine | NA | chemical reagent | NA | 2.50e-01 | 0.0e+00 | CDKN1A,CEBPB,HNF1A,JUN,MAP3K5,PDE3B,RB1,SERPINE1 | 394 (25) |
| YY1 | 2.10e-01 | transcription regulator | NA | 2.50e-01 | 0.0e+00 | AURKA,BCL2L11,BTG2,CDKN1A,CEBPB,CHRDL1,DDIT4,FAS,GADD45G,ID2,ID3,ID4,LDLR,LMNB1,LRP2,MYOM1,NCAPD2,NFKBIZ,NR3C1,PAWR,POLA1,RAD18,RND3,STC1,TBC1D14,TP53INP1 | 449 (24) |
| GW9662 | NA | chemical reagent | NA | 2.50e-01 | 5.0e-02 | CDKN1A,CNTF,FASN,FOXA2,GDF15,INSIG1,MID1IP1,PPARGC1A,TGFB1 | NA |
| ciprofibrate | NA | chemical drug | NA | 2.50e-01 | 0.0e+00 | ADAMTS1,AKR1C4,BAAT,CCND2,CHKA,CRAT,CYP26A1,CYP7A1,GOT1,IGFBP1,MBL2,NPC1,PAH,PALMD,PEX11A,RBM3,SELENBP1,SLC22A25,UPP2 | 318 (14) |
| mir-15 | NA | microRNA | NA | 2.50e-01 | 1.0e-02 | CCND1,CCND2,CCNE1,FASN,FOXO1,MX1,PNPLA2,RNF144B,SOX5,WEE1 | 275 (13) |
| CpG ODN 2006 | NA | chemical reagent | NA | 2.50e-01 | 0.0e+00 | ANKRD33B,BIRC3,BTBD19,CCND2,CD274,CTPS1,CXCL11,DLL1,EIF2B3,HHEX,IFI44,IFI44L,IFIT3,IL15RA,LYN,MAFB,MX1,NFKBIZ,RSAD2,TFRC,TGFB1,TNFAIP3,XBP1,ZC3H12A,ZFP36L1 | 221 (16) |
| miR-16-5p (and other miRNAs w/seed AGCAGCA) | NA | mature microRNA | NA | 2.40e-01 | 0.0e+00 | CA12,CCND1,CCND2,CCNE1,CCNF,CDC14A,CDC14B,CHORDC1,GSTM4,IFRD1,JUN,LAMC1,PPIF,PSAT1,RAB30,RNF144B,SLC25A22,UGDH,UGP2,WEE1 | 196 (7) |
| EPHA2 | 5.40e-01 | kinase | NA | 2.40e-01 | 1.0e-02 | ARRDC3,ATF3,CD274,IL33,JUN,NFKBIZ | NA |
| THRA | 3.60e-01 | ligand-dependent nuclear receptor | NA | 2.40e-01 | 0.0e+00 | CCND1,CDKN1A,CIRBP,CPT1A,CYP7A1,DIO3,Esrra,FASN,INHBA,IRF1,JUN,KLF9,LDLR,NCOA4,NLRP3,NOX4,POR,PPARGC1A,RB1,RIPK3,SERPINE1,TGFB1,THRB,TK1,TOMM20 | 388 (22) |
| RBPJ | 2.00e-02 | transcription regulator | NA | 2.40e-01 | 4.0e-02 | CDKN1A,DLL1,DLL4,EGF,EPHA4,ETHE1,FDFT1,FGF11,IL1RN,INHBA,JUN,MAPK6,NRP2,REN,SOS1 | NA |
| caspase | NA | group | NA | 2.40e-01 | 0.0e+00 | ACER2,CCND1,CCND2,CCNE1,CDKN1A,HERPUD1,RB1 | 424 (26) |
| LGALS3 | 2.40e-01 | other | NA | 2.40e-01 | 0.0e+00 | ARG1,CCND1,CDKN1A,CEBPB,DUSP6,FAS,FASN,FSCN1,LMNB1,PNPLA2,PPARGC1A,RB1,TCF7L2,TGFB1 | 394 (19) |
| IL6R | 1.10e+00 | transmembrane receptor | NA | 2.40e-01 | 5.0e-02 | CCNE1,CDKN1A,IGFBP1,IL6R,IRF1,STAT3,TGFB1,TNFRSF11B | NA |
| lactacystin | NA | chemical - protease inhibitor | NA | 2.40e-01 | 2.0e-02 | ASNS,ATF3,CCND1,CCND2,CDKN1A,FAS,FOXO1,IFRD1,LDLR,MAPK6,MCM10,NFE2L2,NR3C1,SLC3A2,SYK,THRB | NA |
| SLC15A4 | -2.20e-01 | transporter | NA | 2.30e-01 | 4.0e-02 | ADAMTS1,ASNS,CBLB,CD274,EDEM1,IFIT3,MAFB,Oasl2,RGS1,TSC22D1,XBP1 | NA |
| budesonide | NA | chemical drug | NA | 2.30e-01 | 0.0e+00 | ADIPOR2,BCL2L11,CDKN1A,DYNLL1,EFNA5,GNA14,GNA15,HDAC2,IL1RL2,IL1RN,ITPR1,JUN,KIF21A,KLF9,LIMK2,LPIN1,MAF,MAP2K6,MEGF9,MOSPD1,MSMO1,NR3C1,PFKFB3,PLD1,PPL,RASGEF1B,SNX16,SNX24,WDR26 | 385 (15) |
| mir-24 | NA | microRNA | NA | 2.30e-01 | 0.0e+00 | BCL2L11,CDKN1A,HNF1A,ID2,MAF,NET1,SERPINE1,SH3PXD2A,TGFB1 | 339 (16) |
| PRKAA2 | 2.30e-01 | kinase | NA | 2.20e-01 | 1.0e-02 | CDKN1A,FASN,FGFR2,HIGD1A,IFI44,Ifi47,IL17RB,LMO4,NOX4,PPARGC1A,SOS1,TNS1,ZFP36L1 | NA |
| RUNX1-RUNX1T1 | NA | fusion gene/product | NA | 2.20e-01 | 0.0e+00 | ASPA,ATF3,CDKN1A,DUSP6,ETV6,FOXO1,GNA15,ID2,ID3,IL6R,MTSS1,RCBTB2,RND3,RNF144A,UBASH3B,XBP1,ZBTB24,ZFP36L1 | 435 (16) |
| l-asparaginase | NA | biologic drug | NA | 2.20e-01 | 0.0e+00 | ASNS,AURKA,BTG2,CDKN1A,FASN,HMGCS1,INSIG1,LDLR,MSMO1,NCAPD2,NUPR1,ORC1,PCSK9,PSAT1,REM1,SQLE | NA |
| cyanocobalamin | NA | chemical - endogenous mammalian | NA | 2.20e-01 | 0.0e+00 | EGF,FZD1,JUN,PER1,PER2,WNT4 | 279 (7) |
| trastuzumab | NA | biologic drug | NA | 2.20e-01 | 0.0e+00 | CCND1,CCNE1,CDKN1A,CEBPB,LRIG1 | 409 (21) |
| HDAC4 | -4.00e-02 | transcription regulator | NA | 2.20e-01 | 2.0e-02 | ATF3,CCND1,CDKN1A,CHRDL1,DLL4,ETNPPL,HDAC2,IGFBP1,JUN,NR4A2,NRCAM,RGS7,RSAD2 | NA |
| VHL | 1.10e-01 | transcription regulator | NA | 2.20e-01 | 0.0e+00 | AURKA,BCL2L11,BHLHE40,CA12,CCND1,CDKN1A,CPT2,DUOX2,HNF1A,INSIG2,MAF,NOX4,NREP,PFKFB3,RHOF,TFRC,ZFP36L1 | 389 (23) |
| 4-hydroxytamoxifen | NA | chemical drug | NA | 2.10e-01 | 0.0e+00 | ATF3,BCL2L11,BHLHE40,CCND1,CDKN1A,CEBPB,DDIT4,DYNLL1,FOXA1,FOXO1,IGFBP1,JUN,NR4A2,PPARGC1A,RB1,SERPINB9,THRB,TNFAIP3,UNC119 | 411 (23) |
| CCL20 | -2.00e-02 | cytokine | NA | 2.00e-01 | 4.0e-02 | IL1RN,NLRP3,SLC7A2,SYK,ZC3H12A | NA |
| GW3965 | NA | chemical reagent | NA | 2.00e-01 | 0.0e+00 | ABHD5,CHEK2,CIDEC,CYP7A1,CYTH1,CYTIP,EDNRA,FASN,GADD45G,GCK,IL1RN,LDLR,LPIN1,MID1IP1,PTGER3,RGS1,Serpinb6b | 351 (17) |
| Ca2+ | NA | chemical - endogenous mammalian | NA | 1.90e-01 | 0.0e+00 | ABHD5,ANKH,APEX1,ATF3,CCND1,CCND2,CCNE1,CDKN1A,CEBPB,CREM,DBP,FASN,FGFR2,ID3,IL33,IL6R,IRF1,ITPR1,JUN,ODC1,OSCAR,PER1,PER2,PPARGC1A,Rcan1,SERPINE1,SLC12A3,STC1,TCF7L2,TGFB1,TGM1,TNFRSF11B,TRPV6 | 420 (23) |
| EGF | 6.30e-01 | growth factor | NA | 1.80e-01 | 0.0e+00 | ADAMTS1,ATF3,AURKA,BIRC2,BTG2,CCND1,CCND2,CCNE1,CD274,CDKN1A,CEBPB,CISH,CLDN2,CLDN3,CREM,DIO3,DUSP6,FABP7,FASN,FOXA2,GDF15,HMGCS1,HNF4A,ID2,IGFALS,IGFBP1,INHBA,JUN,LIMK2,MAP3K5,MAPK11,NR4A2,ODC1,PER1,PFKFB1,PIK3R1,PPARD,PTPN1,REN,RHOB,SERPINE1,STAT3,SYCP3,TAT,TGFB1,TGM1,TNFAIP1,TNFAIP3,TNFRSF11B,VCAN | 452 (24) |
| carbamylcholine | NA | chemical drug | NA | 1.80e-01 | 4.0e-02 | BTG2,CCND1,CDKN1A,ITPR1,JUN | NA |
| SP600125 | NA | chemical drug | NA | 1.80e-01 | 0.0e+00 | ATF3,BCL2L11,BTG2,CCDC117,CCND1,Cd24a,CDKN1A,CEBPB,CIDEC,CREB3L2,CYP7A1,DDIT4,FAS,FASN,FOXO1,GBP2,HNF4A,IL15,IL17RB,IL1RN,IL6R,INHBA,JUN,LDLR,LGALS9B,MAFB,MAP1LC3B,NUPR1,PER1,PLA2G4A,POLD3,RB1,Serpinb6b,SERPINE1,SGPL1,SLC16A6,TCF7L2,TGFB1,TNFAIP3 | 505 (24) |
| CTBP1 | -2.30e-01 | enzyme | NA | 1.70e-01 | 1.0e-02 | CDKN1A,ENC1,FKBP5,FSCN1,LDLR,NPC1,VCAN | NA |
| MIF | NA | cytokine | NA | 1.70e-01 | 4.0e-02 | ARG1,CCND1,CEBPB,FASN,IFIT3,IL15,IL15RA,JUN,MAP1LC3B,OAS2,SOX6,TGFB1 | NA |
| torkinib | NA | chemical drug | NA | 1.70e-01 | 0.0e+00 | ADAMTS1,ADGRL2,ATF3,AURKA,CCND1,CCNF,CPT1A,DCLRE1B,DDIT4,DHCR24,GREM2,ID3,IFRD1,IL1RN,IL6R,INHBA,KLC4,KPNA2,MCM10,NR4A2,ORC1,POLD3,PPIF,SDC4,SMOX,TK1,TNFAIP8L1 | NA |
| SRF | -1.00e-02 | transcription regulator | NA | 1.60e-01 | 0.0e+00 | AMD1,ATF3,BCL2L11,CDKN1A,CLDN1,CLDN3,DHCR24,GADD45G,GPATCH4,HIF3A,IL15,ITGA9,JUN,LAMA3,LDLR,LIMA1,MAP3K14,MAT1A,MYO1B,MYOM1,NECTIN1,NET1,NOX4,NR4A2,RAMP1,RFX5,RND3,VCAN | 385 (13) |
| ERBB2 | -2.80e-01 | kinase | NA | 1.60e-01 | 0.0e+00 | ABHD5,ADIPOR2,ATF3,AURKA,BCL3,BHLHE40,BIRC3,BTG2,CCND1,CCND2,CCNE1,CDC14B,CDC37L1,CDCA4,CDKN1A,CDT1,CEBPB,CHD1L,CHD7,CHST3,CIDEC,CLDN1,CLDN3,CPT2,DLL1,DUSP6,EDNRB,ELL2,EPHX2,ETV5,ETV6,EXT1,FASN,FOXA1,FOXO1,FSCN1,GART,ID2,IGFBP1,IL6R,IRF6,JUN,LMO4,MAF,MCM10,MCM8,MKNK2,MSLN,NCAPD2,NET1,NNMT,NOX4,NPC1,ORC1,PER1,PFKFB3,POLA1,POLD3,POLG2,POLR3A,PPP2R2B,PTPN1,PTTG1IP,RHOB,SERPINE1,SHROOM3,SIRPA,SLC7A5,SOCS2,SOWAHC,SQLE,ST3GAL6,STAT3,SYCP3,TGFB1,TGM1,TK1,TNFAIP3,TSC22D1,UNC5B,VCAN,WWC1,XBP1,ZNF703 | 428 (23) |
| PPARA | 4.40e-01 | ligand-dependent nuclear receptor | NA | 1.60e-01 | 0.0e+00 | Acot1,AGXT,APEX1,ARG1,ASL,ASNS,ASS1,AURKA,BAAT,CCND1,CCNE1,Cd24a,CDKN1A,CEBPB,CHKA,CHRNA2,CIDEC,CPT1A,CPT2,CYP7A1,DYNLL1,ETHE1,FASN,FDFT1,GCK,GSTT2/GSTT2B,HACL1,HMGCS1,HNF4A,IGFBP1,IL1RN,INSIG1,INSIG2,MBL2,MSMO1,NFE2L2,NR1I2,PAH,PEX11A,PLIN4,PLIN5,PNPLA2,POR,PPARD,PPARGC1A,RBP7,SARDH,SELENBP1,SOCS2,SQLE,STBD1,SYCP3 | 351 (23) |
| PPARGC1B | 1.99e+00 | transcription regulator | NA | 1.50e-01 | 4.0e-02 | CCND1,DHCR24,FASN,FDFT1,GCK,PPARGC1B,SQLE | NA |
| FGFR3 | 2.80e-01 | kinase | NA | 1.50e-01 | 0.0e+00 | CCND1,CD274,CDKN1A,DLL1,DUSP6,IHH,MAF | 359 (18) |
| PNN | 1.10e-01 | other | NA | 1.50e-01 | 0.0e+00 | CDKN1A,GDF15,JUN,TBRG4 | NA |
| collagen type i (family) | NA | group | NA | 1.50e-01 | 4.0e-02 | HNF4A,IL1RN,NR1I2,SERPINE1 | NA |
| CBX7 | -6.00e-02 | other | NA | 1.50e-01 | 4.0e-02 | CBX2,CCND1,CLDN1,GDF15 | NA |
| SMO | -3.80e-01 | G-protein coupled receptor | NA | 1.50e-01 | 4.0e-02 | CCND1,DIO3,FAS,HDAC2,NRCAM,NRP2,SOX5,VCAN | NA |
| arginine | NA | chemical - endogenous mammalian | NA | 1.50e-01 | 1.0e-02 | DDIT4,PIK3R1,PPARGC1A,SLC7A5,TGFB1,XBP1 | 505 (22) |
| camptothecin | NA | chemical drug | NA | 1.40e-01 | 0.0e+00 | ALDOA,AMACR,ARL4A,ATF3,AURKA,BIRC2,BIRC3,BTG2,CCND1,CCNE1,CCNG1,CDKN1A,DDB2,DNAH17,DNAJA1,DUSP6,ENC1,FAS,FNDC3A,FOXO1,FSCN1,GADD45B,GADD45G,GBP2,GSE1,HSPH1,ID3,IL15RA,INSIG1,IRF1,ITPR1,ITSN1,JUN,LDLR,LPIN1,MBNL2,NECTIN1,NLRP3,NR3C1,NR4A2,NUCKS1,P2RY10,PLD1,PPFIA1,PPFIBP2,PPIF,PSTPIP1,PTP4A1,PTPN1,PYCARD,RB1,RBM48,RECQL4,RGS3,RRAGD,RSAD2,SDC4,SERPINB9,SERPINE1,SOWAHC,SYK,SYNE1,TFRC,TGFB1,TLR6,TNFAIP1,TNFAIP3,TNK2,TP53INP1,ZFP36L1 | 393 (20) |
| lisinopril | NA | biologic drug | NA | 1.40e-01 | 1.0e-02 | GBP2,Ifi47,JUN,LDLR,REN,TGFB1 | 288 (10) |
| NCOA5 | -3.00e-01 | other | NA | 1.40e-01 | 0.0e+00 | ARRDC3,Atp8b5,CDKN1A,CIDEC,GADD45G,GDF15,GNA14,MTHFD1,SLC25A30,ZFYVE19 | NA |
| TWIST1 | 5.00e-02 | transcription regulator | NA | 1.30e-01 | 3.0e-02 | ADAMTS1,ARG1,BCL2L11,CBX2,CDKN1A,FAS,FGFR2,FOXO1,IGFBP1,OSGIN1,PPARGC1A,TGFB1,UNC5B,VCAN | NA |
| RXRA | 3.90e-01 | ligand-dependent nuclear receptor | NA | 1.30e-01 | 0.0e+00 | Acot1,ASNS,BAAT,CCND1,CD200R1L,CDKN1A,CPT1A,CPT2,CYP26A1,CYP7A1,DHRS3,FASN,FOXA1,GADD45G,GCK,HNF4A,IGFBP1,INSIG1,KLF9,MID1IP1,NUPR1,ONECUT1,PLD1,POLG2,PPARD,PPARGC1A,REN,RRP12,TGFB1,TK1,VCAN,VMP1,WEE1,ZC3H12A | 494 (25) |
| aphidicolin | NA | chemical toxicant | NA | 1.30e-01 | 2.0e-02 | CDKN1A,IFI44L,MX1,TK1 | NA |
| EGR1 | 2.00e-01 | transcription regulator | NA | 1.30e-01 | 0.0e+00 | ATF3,BAIAP2,BCL2L11,CCND1,CCND2,CDKN1A,CREM,CYP17A1,FAS,GADD45B,GDF15,IL6R,JUN,LDLR,MAP1LC3B,PNPLA2,PTPN1,RB1,SERPINE1,SQLE,TGFB1,WNT4 | 476 (20) |
| ABL1 | -3.00e-02 | kinase | NA | 1.30e-01 | 1.0e-02 | BCL2L11,CCND1,CCND2,CCNE1,CDKN1A,FAS | NA |
| lithium | NA | chemical drug | NA | 1.30e-01 | 4.0e-02 | ADRA1B,CDKN1A,FAS,JUN,PER2,TCF7L2,THRB,XBP1 | NA |
| JUN | -9.30e-01 | transcription regulator | NA | 1.30e-01 | 0.0e+00 | APEX1,ARG1,ASNS,ATF3,BCL2L11,BCL3,BIRC2,BIRC3,CCND1,CCND2,CD274,CDKN1A,CLDN2,CYP17A1,CYP7A1,DUSP6,EPHX2,FABP7,FAS,FOXA1,FOXA2,GOT1,ID2,IGFBP1,JUN,LPIN1,MAF,NFKBIZ,NRCAM,NUPR1,PLA2G4A,PPP2CA,PTPRO,RHOB,SERPINB9,SERPINE1,SLC38A2,Srrm1,SYK,TCF7L2,TGFB1,TK1,WNT4 | 461 (22) |
| glutathione | NA | chemical - endogenous mammalian | NA | 1.30e-01 | 0.0e+00 | ASS1,ATF3,BCL2L11,CCND1,CD274,CDKN1A,DFFB,DLAT,GNL3,SERPINE1,STAT3 | 397 (23) |
| losartan potassium | NA | chemical drug | NA | 1.30e-01 | 0.0e+00 | AGT,CNTF,CREM,EDNRA,EGF,GBP2,Ifi47,KLF15,NOX4,PPARGC1A,REN,SERPINE1,STAT3,TGFB1,XBP1 | 343 (19) |
| MYB | NA | transcription regulator | NA | 1.20e-01 | 2.0e-02 | AURKA,BHLHE40,BIRC3,CCND1,CCNE1,FOXO1,HAND2,ITPR1,JUN,MTSS1,POLA1,SDC4,SLC16A4,SOCS2,ZC3H12A | NA |
| MMP1 | NA | peptidase | NA | 1.20e-01 | 3.0e-02 | CCNE1,CDKN1A,FGFR2,JUN,SERPINE1,TGFB1 | NA |
| valproic acid | NA | chemical drug | NA | 1.10e-01 | 0.0e+00 | AACS,ABHD5,AKR1C4,ATF3,BCL2L11,CA12,CCND1,CCND2,CDKN1A,CHKA,CITED4,CPT1A,CRAT,CTPS1,CYP17A1,EDEM1,ETV6,FAS,FDFT1,FSCN1,GADD45B,GCLM,HERPUD1,HMGCS1,ID2,INSIG2,JUN,LDLR,LIMA1,MSMO1,NFYA,NR3C1,NRG4,PNPLA2,PPP2R2D,PRMT2,RDH16,RNF144A,ROR1,SERPINE1,SQLE,ST3GAL5,STAT3,TCF7L2,TENM3,TGFB1,THRB,TMPO,TNK2,TNS1,XBP1 | 508 (24) |
| LIPE | 4.30e-01 | enzyme | NA | 1.10e-01 | 0.0e+00 | AMACR,ATF3,CEBPB,FASN,FKBP5,ID2,MEOX2,NET1,NRIP1,PER1,PFKFB1,PLIN5,PPARGC1A,RAMP1,RB1,SDC4,ST3GAL5,TGFB1 | 364 (21) |
| N-nitro-L-arginine methyl ester | NA | chemical drug | NA | 1.10e-01 | 2.0e-02 | AGT,ATF3,FAS,INSIG1,LDLR,PPARD,PPARGC1A,REN,SERPINE1,TGFB1 | NA |
| prostaglandin E2 | NA | chemical - endogenous mammalian | NA | 1.10e-01 | 0.0e+00 | 9930111J21Rik1/Gm12185,ADAMTS1,ARG1,ATF3,BCL2L11,BIRC3,CCND1,CD274,CDKN1A,CEBPB,CREM,CYTH1,CYTIP,DLL1,DYNLL1,FAS,FASN,FBXO31,FOXO1,FSCN1,IGFBP1,IL15RA,IL1RN,IRF1,JUN,LYSMD2,MAFB,NFKBIZ,NR4A2,PLA2G4A,PLEKHA4,PYCARD,RASGEF1B,SOCS2,TCF7L2,TFRC,TGFB1,TNFRSF11B,TSC22D1 | 405 (20) |
| TGFB1 | -6.00e-01 | growth factor | NA | 1.10e-01 | 0.0e+00 | AASS,Acot1,ADCY9,ADGRG2,ALDOA,AMD1,ANKH,ARG1,ARHGAP24,ARHGEF19,ARL4A,ASNS,ASS1,ATF3,ATP1B1,AURKA,BCL2L11,BCL3,BHLHE40,BIRC3,CCND1,CCND2,CCNE1,CCNF,CD101,CD274,CDKN1A,CDT1,CEBPB,CEMIP,CHST3,CIDEC,CLDN1,CTPS1,CYP17A1,CYP7A1,DACT1,DBP,DDB2,DDIT4,DHCR24,DNAJA1,DTX4,DYNLL1,EDNRA,EDNRB,EGF,ELAVL1,EXT1,FAS,FASN,FGFR2,FOXA1,FOXA2,FOXO1,FSCN1,FZD1,GADD45B,GBP2,GDF15,GNA14,GPR146,GSE1,HDAC2,HHEX,HMGCS1,HNF1A,HNF4A,ID2,ID3,ID4,IFIT3,IFRD1,IL15,IL17RB,IL1RN,IL33,IL6R,INHBA,INSIG1,IRF1,ITPR1,JUN,Kcnn2,KLF15,KLF9,KLRD1,LAMC1,LDLR,LIMK2,LSM2,MAF,MAPK6,MBNL2,MKNK2,MSMO1,NCAPD2,NET1,NFE2L2,NLRP3,NNMT,NOX4,NR4A2,NUPR1,ORC1,P4HA1,PATZ1,PAX8,PDE7A,PFKFB3,PLA2G4A,PPARD,PPARGC1A,PPFIBP2,PPP1R13B,PPP1R3C,PPP2CA,PSAT1,PYCARD,RASGEF1B,RB1,RBM3,RHOB,ROR1,RSAD2,S1PR1,S1PR2,SDC4,SELENBP1,SERPINE1,SLC1A4,SLC3A2,SLC7A5,SQLE,SRFBP1,SRSF4,ST3GAL5,ST3GAL6,STAT3,TCF7L2,TFRC,TGFB1,TNFAIP3,TNFRSF11B,TNFRSF14,TPST2,TSC22D1,UNC119,VCAN,WNT4,XBP1,ZNF354A | 529 (23) |
| CRY1 | 5.00e-02 | enzyme | NA | 1.00e-01 | 0.0e+00 | DBP,IHH,PER1,PER2 | 74 (6) |
| PD98059 | NA | chemical - kinase inhibitor | NA | 1.00e-01 | 0.0e+00 | AGT,ALDOA,AMD1,ATF3,BCL2L11,CCND1,CCND2,CCNE1,CDKN1A,CEBPB,CREM,CYP17A1,CYP7A1,DHRS3,DIO3,DUSP6,EDNRB,FAS,FASN,FKBP5,ID3,IGFBP1,IL1RN,INSIG1,JUN,KLF15,LAMA3,LDLR,MCM8,NFE2L2,NFYB,NOP56,NPC1,ODC1,PAWR,PCSK6,PCYT1A,PER1,PFKFB1,PIK3R1,PLA2G4A,PPARD,RB1,REN,RGS1,SELENBP1,SERPINE1,SIRPA,SLC38A2,SLC3A2,SOCS2,SQLE,STAT3,STC1,STOM,TGFB1,TNFRSF11B,TOMM40,TSC22D1,VCAN,WNT4,XBP1,ZFP36L1 | 424 (23) |
| PI3K (complex) | NA | complex | NA | 1.00e-01 | 0.0e+00 | ATF3,BCL2L11,BIRC3,CCND1,CCND2,CCNE1,CD274,CD79B,CDKN1A,CEBPB,CYP7A1,DDIT4,DLL4,FOXO1,GCLM,IGFBP1,IL1RN,IL33,JUN,MAP3K5,NFE2L2,NOX4,NR4A2,PLA2G4A,Rcan1,RHOB,RND3,SERPINE1,SLC26A3,TNFAIP3,XBP1 | 448 (23) |
| MAPK1 | 3.00e-02 | kinase | NA | 1.00e-01 | 0.0e+00 | ATF3,ATP1B1,AURKA,CCND1,CCNF,CDK19,CDKN1A,CISH,CXCL11,FAM20A,FOXO1,GBP2,HSD17B2,IFI44,IFIT3,IL1RN,JUN,MAST3,NFE2L2,NRN1,NUPR1,OAS2,ORC1,PLA2G4A,PLD1,PSAT1,SECTM1,SERPINE1,SOCS2,SPSB1,STC1,ZNF184 | 387 (22) |
| semaxinib | NA | chemical drug | NA | 9.00e-02 | 0.0e+00 | ALDOA,ARG1,ATF3,CCNE1,CLEC10A,CXCL11,EPHX2,FOXO1,GDF15,IL15,IL21R,NFE2L2,NLRP3,NR4A2,SEMA6B,SERPINE1,TGFB1,TNFRSF14 | 493 (24) |
| ATF3 | -8.40e-01 | transcription regulator | NA | 9.00e-02 | 0.0e+00 | ASNS,ATF3,AURKA,BIRC3,CCND1,CCNE1,CDKN1A,CTPS1,GBP2,JUN,LDLR,NFKBIZ,POLA1,POLD3,PSAT1,RSAD2,SERPINE1,STAT3,TK1,XBP1 | 409 (22) |
| PF4 | -4.60e-01 | cytokine | NA | 9.00e-02 | 0.0e+00 | BIRC3,CDKN1A,CMPK2,FOXA2,HNF1A,IL1RN,INHBA,IRF1,NFE2L2,NFKBIZ,RSAD2,TGFB1,TNFAIP3 | 396 (21) |
| TNFSF11 | NA | cytokine | NA | 8.00e-02 | 0.0e+00 | AURKA,CCND1,CCNE1,CD300LF,CDKN1A,DOK2,DUSP6,FAS,FGR,FOXO1,GADD45B,IFRD1,IL15,IL15RA,IL1RN,JUN,MAFB,NFKBIZ,OSCAR,PLD1,POR,RHOB,SDC4,Serpinb6b,SERPINB9,SERPINE1,SH3PXD2A,TGFB1,TNFRSF11B,VRK1 | 397 (18) |
| anti-benzo(a)pyrene-diol-epoxide | NA | chemical toxicant | NA | 8.00e-02 | 0.0e+00 | BCL2L11,CCND1,CDKN1A,GADD45B,JUN | 450 (22) |
| miR-182-5p (and other miRNAs w/seed UUGGCAA) | NA | mature microRNA | NA | 8.00e-02 | 0.0e+00 | CMPK2,CYP7A1,FNDC3A,FOXO1,GADD45G,IFI44L,IGFBP1,MTSS1,OAS2,PAX8,RSAD2,RTP4,SOS1 | NA |
| cerivastatin | NA | chemical drug | NA | 8.00e-02 | 0.0e+00 | ASS1,CDKN1A,ETV6,HMGCS1,JUN,NET1,NFYA,PCSK9,SERPINE1,TGFB1 | 412 (20) |
| PML | -5.40e-01 | transcription regulator | NA | 7.00e-02 | 0.0e+00 | CCND1,CCNE1,CDKN1A,CIAPIN1,CPT1A,CXCL11,FAS,FASN,GCLM,HMGCS1,ID2,IFI44,IFI44L,IFIT3,LDLR,MAF,MAPK11,MX1,NFE2L2,NR3C1,OAS2,PPARGC1A,TNFAIP3 | 410 (20) |
| HRAS | 2.10e-01 | enzyme | NA | 7.00e-02 | 0.0e+00 | AMACR,ASNS,AURKA,BCL2L11,BIRC3,BTG2,CBX2,CCND1,CCND2,CCNE1,CCNG1,CD274,CDKN1A,CEBPB,CGREF1,CISH,CLCF1,CPT1A,CXCL11,DLL1,DOK2,DUSP6,ETV5,FAS,FASN,FDFT1,FOXO1,FZD1,GADD45G,GNA14,ID2,JUN,LMNB1,MSMO1,NUCKS1,OAF,PAWR,PCYT1A,PER2,PLA2G4A,PPARGC1B,RHOB,SERPINB9,SERPINE1,SHROOM3,SIRPA,SOCS2,SOX5,SPSB4,SQLE,TENM3,TGFB1,TINAGL1,TK1,TNFRSF11B,TSC22D1,UBASH3B,VCAN | 440 (24) |
| IL3 | NA | cytokine | NA | 7.00e-02 | 0.0e+00 | ARG1,ARHGAP29,BCL2L11,BIRC3,BTG2,CCND1,CCND2,CCNG1,CDKN1A,CIAPIN1,CISH,CPT1A,CRAT,CREM,DOK2,FAS,FASN,GADD45B,GADD45G,GART,HNF1A,HNF4A,IL17RB,IL33,JUN,KLF9,LYN,NIFK,ODC1,RB1,RBM3,SLC3A2,SLC7A5,SOX5,TK1,XBP1 | 403 (22) |
| PRKCE | 3.80e-01 | kinase | NA | 6.00e-02 | 0.0e+00 | BIRC3,CCND1,CCNE1,CDKN1A,CEBPB,JUN,LDLR,ODC1,PTGER3,STAT3 | 435 (23) |
| CSF1R | 1.40e-01 | kinase | NA | 6.00e-02 | 0.0e+00 | ARG1,CCND1,CCND2,CCNE1,CDKN1A,JUN,STAT3 | 349 (19) |
| Bcl9-Cbp/p300-Ctnnb1-Lef/Tcf | NA | complex | NA | 6.00e-02 | 0.0e+00 | CCND1,HNF1A,PPARD,TCF7L2 | NA |
| NTRK3 | -3.00e-01 | kinase | NA | 6.00e-02 | 4.0e-02 | BIRC3,CDKN1A,SERPINE1,TNFAIP3 | NA |
| cigarette smoke | NA | chemical toxicant | NA | 6.00e-02 | 0.0e+00 | CCND1,CDKN1A,DDIT4,GADD45G,GCLM,HDAC2,JUN,MAP1LC3B,MX1,NFE2L2,NOX4,OAS2,Oasl2,PTPN1,PYCARD,SERPINE1,SLC1A4,UBC,UGDH,XBP1 | 447 (22) |
| FASN | -6.40e-01 | enzyme | NA | 6.00e-02 | 1.0e-02 | CIDEC,DDIT4,DHCR24,EDNRB,FASN,FOXO1,PNPLA2,RBP7 | NA |
| mir-8 | NA | microRNA | NA | 6.00e-02 | 4.0e-02 | ABL2,ADAMTS1,ATF3,CCND1,CCND2,CDKN1A,CLDN1,CLDN3,CPT1A,FGFR2,GSE1,MSLN,UBE2D1,Wasl,XBP1 | NA |
| WNT5A | -4.60e-01 | cytokine | NA | 5.00e-02 | 0.0e+00 | ARG1,BTG2,CCND1,DLL1,DOK2,EPHA4,ID2,ID3,IL15,IRF1,LAMA3,MAP3K21,MAP3K9,MUL1,PTPN1,SDC4,SH3PXD2A,STAMBPL1,STAT3,STC1,SYK,TGFB1,ZNF385B | 404 (17) |
| FOXD3 | NA | transcription regulator | NA | 5.00e-02 | 0.0e+00 | CDKN1A,FOXA1,FOXA2,RND3 | NA |
| RNF187 | -9.00e-02 | enzyme | NA | 5.00e-02 | 0.0e+00 | ATF3,BHLHE40,BTG2,CCND1,CDKN1A,IRF1,JUN,LDLR,PPP1R9B,TP53INP1,ZFP36L1 | 333 (10) |
| sterol | NA | chemical - endogenous mammalian | NA | 5.00e-02 | 0.0e+00 | CYP7A1,FASN,FDFT1,LDLR,LPIN1,PCSK9,PCYT1A | 147 (12) |
| cuprizone | NA | chemical toxicant | NA | 5.00e-02 | 0.0e+00 | ACER2,ASPA,BACH2,CIART,FAM78A,FDFT1,GYS1,HMGCS1,HSPH1,ITPR1,JAM3,NCOA4,NLRP3,PYCARD,S1PR1,TFRC,TGM1 | NA |
| INHBA | -1.82e+00 | growth factor | NA | 5.00e-02 | 1.0e-02 | ATXN7L1,CCND1,CCND2,CDKN1A,CHD7,CYP17A1,EDAR,FOXA2,HNF1A,INHBA,IRF1,IRX1,MAF,MAFB,NR4A2,PCSK6,PSMD9,SERPINE1 | 421 (26) |
| zinc | NA | chemical drug | NA | 5.00e-02 | 1.0e-02 | ASPG,CCND1,FAS,HNF4A,KPNA2,RB1,SELENBP1,SLC30A2,TFRC | NA |
| ruxolitinib | NA | chemical drug | NA | 4.00e-02 | 0.0e+00 | CBS/LOC102724560,CCND1,CD274,CD79B,CISH,FOXA1,IL17RB,IL6R,MAP1LC3B,NLRP3,PSAT1,PYCARD,SOCS2,STAT3 | 325 (14) |
| CHUK | 2.90e-01 | kinase | NA | 4.00e-02 | 0.0e+00 | ATF3,CCND1,CDKN1A,CEBPB,CLDN1,DUSP6,EGF,FAS,GADD45B,GBP2,IL1RN,NOCT,PLA2G4A,PPARGC1B,RB1,Rtp3,TK1,TNFAIP3,TNFRSF11B | 420 (17) |
| HNF1A | 8.90e-01 | transcription regulator | NA | 2.00e-02 | 0.0e+00 | AGT,AKR1C4,ALS2,ANKS4B,ASB7,BACH2,BCL6B,CBS/LOC102724560,CCND1,CCNE1,CLDN2,COQ10B,CYP7A1,DCAF13,DUSP6,ETV5,FAS,FOXA2,FOXJ3,GCK,GOT1,GTF2E1,HACL1,HNF1A,HNF4A,HSD17B2,IGFALS,IGFBP1,IHH,KLF11,LDLR,MID1IP1,MTHFD1,MTMR11,ONECUT1,PAH,PCSK9,PFKFB2,PPCS,SERPINA10,SERPINA7,SERPINE1,SGK2,SLC17A2,SLC38A4,SLC7A2,SLCO1B3,TAT,TFRC,TMEM140,XBP1,ZBED3 | 498 (21) |
| BDNF | 4.40e-01 | growth factor | NA | 2.00e-02 | 2.0e-02 | APEX1,BCL2L11,BHLHE40,CCND2,CDKN1A,CEBPB,DUSP6,FSCN1,HIVEP1,IFRD1,ITPR1,JUN,LAMC1,NCDN,P4HA1,PALMD,PER2,PFKFB3,PREP,RPRM,SBK1,TBC1D8,TFRC,TNFRSF11B | NA |
| POR | 2.14e+00 | enzyme | NA | 0.00e+00 | 0.0e+00 | Acot1,ASNS,CAPRIN2,CHMP4C,CLDN3,CPT1A,CPT2,CYP17A1,CYP26A1,CYP7A1,DHCR24,ETHE1,FDFT1,FLVCR2,GADD45B,GBP2,GCK,HMGCS1,Hsd3b4 (includes others),HSPH1,IHH,INSIG1,LDLR,LGALSL,MAP3K6,MSMO1,NOCT,NRG4,PFKFB3,PNPLA7,POR,RAB30,SDC4,SDS,SQLE,UGDH | 99 (3) |
| GNAQ | -8.00e-02 | enzyme | NA | 0.00e+00 | 0.0e+00 | ADAMTS1,ARG1,ATF3,BTG2,CCND1,CCNG1,CLCF1,CREM,GALE,GBP2,HAND2,HIGD1A,IL1RN,INSIG1,KLF15,MAPK11,MEOX2,NR4A2,RHOB,SELENBP1,SERPINE1,TGM1,ZFP36L1 | 454 (22) |
| IgG | NA | complex | NA | 0.00e+00 | 0.0e+00 | ATP1B1,BCL3,BHLHE40,BIRC2,BIRC3,CCND2,CD274,CDKN1A,CEBPB,CLDN3,CPT1A,FOXO1,GADD45B,IL15,IL1RN,IL6R,INHBA,IRF1,LDLR,MAF,MAFB,PDE3B,PPARGC1A,PPIF,PPL,RHOB,RND3,S1PR1,SDC4,SERPINE1,SLC16A6,STAT3,TGFB1,TNFAIP3,UBC | 411 (17) |
| NCOR1 | -3.30e-01 | transcription regulator | NA | 0.00e+00 | 0.0e+00 | BCL3,CCND1,CDKN1A,CREM,CSF3R,CYP17A1,CYP7A1,FASN,IFIT3,IGFBP1,IL15,Oas1b,OAS2,Oasl2,PFKFB1 | 433 (26) |
| tributyrin | NA | chemical drug | NA | 0.00e+00 | 0.0e+00 | ATF3,BIRC3,CD274,CDKN1A,CLDN1,HNRNPD,ID2,ID3,INHBA,TNFAIP3 | NA |
| NEDD9 | -4.40e-01 | other | NA | 0.00e+00 | 0.0e+00 | ATP2B2,AURKA,BHLHE40,DDIT4,EDDM3B,GDF15,LIN7A,MKNK2,NRN1,PAX8,SERPINE1,STC1 | 287 (12) |
| TREM1 | 2.30e-01 | transmembrane receptor | NA | 0.00e+00 | 0.0e+00 | ABL2,ASNS,ATF3,ATP1B1,CD274,CEBPB,FNDC3A,GADD45B,GCLM,IL15RA,IL6R,INHBA,IRF1,NPC1,NR4A2,OSGIN1,PLD1,PTTG1IP,RGS1,TMPO | 340 (14) |
| vanillin | NA | chemical - endogenous non-mammalian | NA | 0.00e+00 | 0.0e+00 | DDIT4,DUSP6,FGFR2,GCLM,INSIG1,UGP2 | NA |
| raloxifene | NA | chemical drug | NA | 0.00e+00 | 0.0e+00 | ADCY9,BCL3,CCND1,CDKN1A,DDIT4,DYNLL1,IRF6,JUN,LDLR,MYO1B,PLK3,PPP1R3C,PTGER3,SELENBP1,SERPINE1,STC1,TFRC,TNFRSF11B | 464 (23) |
| NFYA | -7.30e-01 | transcription regulator | NA | 0.00e+00 | 0.0e+00 | CBS/LOC102724560,CDKN1A,CHEK2,FASN,FGFR2,GADD45B,IRF1,JUN,LPIN1,POLA1,RHOB | 403 (17) |
| RPL22 | 4.00e-02 | translation regulator | NA | 0.00e+00 | 0.0e+00 | ATF3,BCL2L11,CDKN1A,XBP1 | 266 (10) |
| CFTR | -1.00e-02 | ion channel | NA | 0.00e+00 | 0.0e+00 | ASNS,EPHX2,FAS,FDFT1,HDAC2,HSD17B2,ITPR1,NFKBIZ,POR,SQLE,TNFAIP3 | 405 (15) |
| CD5 | NA | transmembrane receptor | NA | 0.00e+00 | 0.0e+00 | BCL3,CEBPB,FAS,LDLR,MSMO1,STAT3,TGFB1,UBE2D1 | 254 (12) |
| SS18 | 6.00e-02 | transcription regulator | NA | 0.00e+00 | 1.0e-02 | BCL2L11,DLL1,FGFR2,GADD45B,SLC34A2,SYNE1 | NA |
| CSF | NA | group | NA | 0.00e+00 | 1.0e-02 | CD274,IL1RL2,IL1RN,SERPINB8,SERPINB9,SERPINE1,TNFAIP3,TNFRSF14 | NA |
| MGA | 1.70e-01 | transcription regulator | NA | 0.00e+00 | 1.0e-02 | Acot1,BTG2,CCND1,CLDN2,NREP,RNF157,SYCP3,TDRKH | NA |
| SORL1 | NA | transporter | NA | 0.00e+00 | 1.0e-02 | ADCYAP1R1,AGT,EDNRA,EFNA1,EFNA5,EPHA4,FGFR2,INHBA,LAMC1,LRP2,NRP2,PLXND1,ROR1,SDC4,TGFB1,TNFRSF11B | 282 (7) |
| HSD11B1 | 1.30e-01 | enzyme | NA | 0.00e+00 | 1.0e-02 | AGT,CPT1A,FASN,PFKFB3,PNPLA2,PPARGC1A | 438 (27) |
| E. coli serotype 0127B8 lipopolysaccharide | NA | chemical - endogenous non-mammalian | NA | 0.00e+00 | 1.0e-02 | Acot1,ADGRG2,EDEM1,EDNRA,EDNRB,FZD1,GNA14,GPR146,Ifi47,IL15,IRF1,LAMC1,RSAD2,SLC7A5,STAT3,TNFRSF11B | 330 (16) |
| PDK1 | 2.00e-02 | kinase | NA | 0.00e+00 | 1.0e-02 | FOXO1,GALC,ID3,MAP3K14,NRN1,PIK3R1,SGPL1,SYNE1 | NA |
| PKNOX2 | 4.00e-02 | transcription regulator | NA | 0.00e+00 | 1.0e-02 | BTG2,CDKN1A,FAS,RPRM | NA |
| PTPN11 | -1.00e-02 | phosphatase | NA | 0.00e+00 | 1.0e-02 | CCND1,CCNG1,CDKN1A,CSF3R,FASN,IFIT3,JUN,LYN,MAP3K5,RPRM,TCF7L2 | NA |
| THZ1 | NA | chemical drug | NA | 0.00e+00 | 1.0e-02 | ADAMTSL2,ASS1,ATF3,ATXN7L1,BIRC3,CYTIP,LYST,MTSS1,NUPR1,RAPH1,SERPINE1,VCAN | NA |
| ASPSCR1-TFE3 | NA | fusion gene/product | NA | 0.00e+00 | 1.0e-02 | ATP6V1B2,BHLHE40,CYP17A1,DEXI,GDF15,POPDC2,PPARGC1A,RRAGD,SLC19A2,STOM | NA |
| LAMA4 | -4.70e-01 | enzyme | NA | 0.00e+00 | 1.0e-02 | CCND1,CCND2,DLL4,GSTM4,GSTO2,GSTT2/GSTT2B,IL15,IL6R,LAMC1,TNFRSF14 | NA |
| EIF4G2 | 0.00e+00 | translation regulator | NA | 0.00e+00 | 2.0e-02 | CCND2,CDKN1A,JUN,SOS1 | NA |
| farnesol | NA | chemical reagent | NA | 0.00e+00 | 2.0e-02 | ATF3,CDKN1A,HERPUD1,XBP1 | NA |
| SOD1 | -5.00e-02 | enzyme | NA | 0.00e+00 | 2.0e-02 | APEX1,ASL,ASS1,C5AR2,CACNB4,CCND1,FAS,GCLM,IFI44,IL15,INHBA,JUN,MYOM1,NFE2L2,OAS2,PAWR,RBM3,RSAD2,TFRC,TGFB1,TNFAIP3 | NA |
| retinol | NA | chemical drug | NA | 0.00e+00 | 2.0e-02 | CYP26A1,JUN,PPARD,TGFB1 | NA |
| SUZ12 | 1.00e-01 | enzyme | NA | 0.00e+00 | 2.0e-02 | ABL2,CYP26A1,FOXA1,HAND2,HNF4A,INSIG1,PCDH20,POU2F3,PPP2R2B,SLC7A5,TGFB1,TNFRSF11B | NA |
| CASR | -4.60e-01 | G-protein coupled receptor | NA | 0.00e+00 | 2.0e-02 | CCND1,CCND2,CDT1,CISH,CLDN14,GADD45G,NCAPD2,NUPR1,ODC1,RB1,RNF144A,TK1 | NA |
| H2AB3 (includes others) | NA | other | NA | 0.00e+00 | 3.0e-02 | ATF3,BCL2L11,CDKN1A,EFNA1,HIP1R,SERPINB9 | NA |
| TIMP3 | -1.10e-01 | other | NA | 0.00e+00 | 3.0e-02 | CEBPB,FAS,JUN,SERPINE1,STAT3,TGFB1 | NA |
| kanamycin A | NA | chemical drug | NA | 0.00e+00 | 3.0e-02 | BACH1,CCND1,CNTF,MYO1B,NRIP1,SEC22B,SOCS2,ST3GAL6,STAT3,USP2 | NA |
| KDM6A | NA | enzyme | NA | 0.00e+00 | 3.0e-02 | ANKS4B,CD274,HNF4A,IGFALS,PAH,SERPINA10 | NA |
| RETNLB | NA | other | NA | 0.00e+00 | 3.0e-02 | FZD1,KLF15,LMNB1,MAP3K6,SOCS2,STOM,TGFB1,TINAGL1 | NA |
| progestin | NA | chemical drug | NA | 0.00e+00 | 4.0e-02 | CCND1,FOXO1,SYNE1,TBC1D14 | NA |
| CEBPE | 1.60e-01 | transcription regulator | NA | 0.00e+00 | 4.0e-02 | CCND2,CCNE1,CEBPB,CLEC10A,CSF3R,IL1RN | NA |
| LMO2 | -2.10e-01 | transcription regulator | NA | 0.00e+00 | 4.0e-02 | ABL2,CCND2,CD79B,CDKN1A,CLDN2,HHEX,INPP5B,KLF11,LYN,MAP3K5,NPRL3,Oasl2,PATZ1,PLA2G4A,PSTPIP1,SMOX,STAT3,TGFB1,TNFAIP3,TOR3A | NA |
| NGEF | 2.10e-01 | other | NA | 0.00e+00 | 4.0e-02 | CCND2,IFI44L,KCNJ8,MAFB,MAST3,MX1,PFKFB1,SLC12A3 | NA |
| SH3TC2 | -2.50e-01 | other | NA | 0.00e+00 | 4.0e-02 | AACS,DHCR24,HMGCS1,SQLE | NA |
| pemetrexed | NA | chemical drug | NA | 0.00e+00 | 4.0e-02 | ARRDC3,CDKN1A,GDF15,LYSMD2 | NA |
| infliximab | NA | biologic drug | NA | 0.00e+00 | 4.0e-02 | CCND2,DDIT4,IL15,INHBA,MYO1B,SLC7A5,WEE1 | NA |
| LLGL2 | 1.80e-01 | other | NA | 0.00e+00 | 4.0e-02 | ETV5,FSCN1,SERPINE1,TNS1 | NA |
| ELL2 | 1.44e+00 | transcription regulator | NA | 0.00e+00 | 5.0e-02 | CREB3L2,CYP26A1,EDEM1,FNDC3A,SEC24D,XBP1 | NA |
| LDB1 | 3.90e-01 | transcription regulator | NA | 0.00e+00 | 5.0e-02 | ABL2,CCND2,CD79B,CDKN1A,CLDN2,HHEX,INPP5B,KLF11,LYN,MAP3K5,NPRL3,Oasl2,PATZ1,PLA2G4A,PSTPIP1,SMOX,STAT3,TGFB1,TNFAIP3,TOR3A | NA |
| HBEGF | 1.60e-01 | growth factor | NA | 0.00e+00 | 5.0e-02 | ALDOA,BCL3,BHLHE40,CCND1,CCND2,NFKBIZ | NA |
| IGF2 | -7.00e-02 | growth factor | NA | 0.00e+00 | 5.0e-02 | ARL4A,CCND1,CDKN1A,FABP7,FEM1A,KLF9,PIK3R1,PSPC1,RHOB,SERPINE1,SLC38A2,TAT,TOMM40 | NA |
| DSCAML1 | 5.00e-02 | other | NA | 0.00e+00 | 5.0e-02 | ETV5,GADD45G,ID3,KLF9,NRCAM,NRN1,PLD1,SOX6 | NA |
| IL17A | NA | cytokine | NA | -2.00e-02 | 1.0e-02 | BCL3,CCND1,CD274,CEBPB,DUOX2,FAS,GBP2,IL1RN,IL33,IRF1,ITPR1,JUN,NFKBIZ,NR4A2,S1PR1,S1PR2,SERPINE1,SLC12A3,SPSB1,STAT3,TGFB1,TNFAIP3,TNFRSF11B,TNFRSF14,ZC3H12A | 414 (17) |
| methylnitronitrosoguanidine | NA | chemical toxicant | NA | -2.00e-02 | 0.0e+00 | BTG2,CCND1,CDKN1A,FAS,GDF15,IRF1,SERPINE1 | 394 (23) |
| Gsk3 | NA | group | NA | -3.00e-02 | 1.0e-02 | BCL2L11,CCND1,FASN,FSCN1,GDF15,JUN,LDLR,NR4A2,TNFAIP3 | NA |
| EPAS1 | 4.50e-01 | transcription regulator | NA | -5.00e-02 | 0.0e+00 | ARG1,BHLHE40,BIRC3,CA12,CCND1,CD274,CDKN1A,CEBPB,CEMIP,CHKA,CLDN1,FASN,GADD45B,HMGCS1,ITPR1,LDLR,NCOA4,NRN1,PFKFB3,PTK6,SERPINE1,SLC16A4,SLC7A5,TGFB1,TNFAIP3,TNFRSF11B,UGP2 | 412 (19) |
| Pam3-Cys-Ser-Lys4 | NA | chemical reagent | NA | -5.00e-02 | 0.0e+00 | BCL2L11,CD180,CD274,CLDN1,HIVEP1,IL15,IRF1,JUN,NFKBIZ,NLRP3,PARP14,RGS1,SERPINE1,SLC3A2,TLR6,TNFAIP3,TNFRSF14,XBP1 | 409 (18) |
| gentamicin | NA | chemical drug | NA | -5.00e-02 | 0.0e+00 | ALPL,APEX1,ASL,ATF3,AZIN1,BACH1,BTG2,CBS/LOC102724560,CCND1,CCNG1,CEBPB,CHKA,CHORDC1,CIPC,EGF,EPHX2,Fn3k,GDF15,GNL3,Gnmt,HACL1,HNF4A,IFRD1,IGFBP1,IRF1,JUN,L3HYPDH,MAF,MAPK6,MAPKAPK3,MYO1B,NRIP1,PSAT1,PTP4A1,PTPN1,RIPK3,RNF4,SEC22B,SOCS2,ST3GAL6,STAT3,TFRC,TGFB1,TMEM120A,TSC22D1,USP2,ZFP36L1,ZNF354A | NA |
| JAK1 | -9.00e-02 | kinase | NA | -6.00e-02 | 2.0e-02 | BCL2L11,BCL3,CDKN1A,IRF1,MX1,Oasl2,STAT3,TGFB1 | NA |
| sodium arsenite | NA | chemical drug | NA | -6.00e-02 | 0.0e+00 | CBS/LOC102724560,CCND1,CCND2,CDKN1A,CISH,FKBP5,GADD45B,GCLM,JUN,NFE2L2 | 412 (23) |
| 5-fluorouracil | NA | chemical drug | NA | -6.00e-02 | 0.0e+00 | ALDOA,ATF3,BAIAP2,BCL2L11,BIRC2,BTG2,CCND1,CCND2,CCNG1,CDKN1A,DDB2,DLL1,DLL4,FAS,FGFR2,FOXO1,GDF15,JUN,NOP56,NUCKS1,OSGIN1,PLK3,RB1,RGS7,RHOB,STOM,TGFB1,TSC22D1,ZFP36L1 | 464 (25) |
| roscovitine | NA | chemical drug | NA | -6.00e-02 | 1.0e-02 | BCL2L11,CCND1,CD274,CDKN1A,JUN,PCYT1A,RB1 | 369 (20) |
| miR-18a-5p (and other miRNAs w/seed AAGGUGC) | NA | mature microRNA | NA | -7.00e-02 | 2.0e-02 | BCL2L11,CCND1,CDKN1A,SOX6 | NA |
| CALCA | NA | other | NA | -7.00e-02 | 0.0e+00 | ALDOA,ARG1,CREM,GADD45B,ID2,IL17RB,LIMA1,LMO4,NR3C1,ODC1,Plekha6,PSAT1,RAMP1,SDC4,SEC22B,SERPINB9,SERPINE1,SOS1,TNFAIP3,TNS1 | 421 (18) |
| COP1 | NA | enzyme | NA | -7.00e-02 | 1.0e-02 | CA12,CDKN1A,CEBPB,CISH,ETV5,FAS,IL17RB,PEX11A,PPARGC1A | 389 (17) |
| AGN194204 | NA | chemical drug | NA | -7.00e-02 | 0.0e+00 | Acot1,ASS1,ATF3,AURKA,Cd24a,CDKN1A,CHKA,CPT1A,EPB41,FDFT1,FOXA2,GBP2,Ifi47,Igtp,IL33,IRF1,NRIP1,NRXN2,PLIN4,PPARGC1A,PPL,SLC3A2,XBP1 | 162 (7) |
| TOB1 | 4.30e-01 | transcription regulator | NA | -7.00e-02 | 1.0e-02 | BANP,CCND1,CDKN1A,CDT1,MBNL2,RPRM,WDHD1 | 284 (11) |
| RIPK2 | 2.10e-01 | kinase | NA | -7.00e-02 | 0.0e+00 | CMPK2,CYP7A1,FASN,HELZ2,IFI44,IFI44L,IFIT3,IL33,LDLR,LMO4,MAP3K6,MAPK11,MX1,OAS2,PNPLA2,PPARD,PPARGC1A,RSAD2,TNFAIP3 | 439 (19) |
| TSC2 | -2.10e-01 | other | NA | -8.00e-02 | 4.0e-02 | ATF3,ATP6V1B2,BCL3,CCND1,CCND2,CDKN1A,FASN,GALC,IFI44,Ifi47,IL17RB,NPC1,SOS1 | NA |
| cycloheximide | NA | chemical reagent | NA | -8.00e-02 | 0.0e+00 | ADRA1B,ALDOA,ASS1,BIRC3,BTG2,CCND1,CDKN1A,CEBPB,DDIT4,DIO3,FAS,GADD45B,GADD45G,GCLM,GOT1,HNF4A,IGFBP1,IL1RN,JUN,KSR2,NFE2L2,NR3C1,PAX8,PFKFB3,RBM3,RHOB,RSAD2,SERPINE1,TGFB1,THRB,TK1,TNFAIP3,TNFRSF11B | 423 (20) |
| mycophenolic acid | NA | chemical drug | NA | -9.00e-02 | 0.0e+00 | ATF3,BIRC3,CCND2,CD274,CDKN1A,CLDN1,GNL3,HNRNPD,ID2,ID3,INHBA,LDLR,SERPINE1,TNFAIP3 | 385 (21) |
| atorvastatin | NA | chemical drug | NA | -9.00e-02 | 1.0e-02 | CRCP,CYP7A1,DHCR24,EDNRA,FDFT1,GADD45B,HMGCS1,JUN,LDLR,MSMO1,NOX4,PCSK9,RGS1,RHOB,SERPINE1,SLCO1B3,SQLE,TGFB1 | NA |
| CD44 | -5.00e-02 | other | NA | -9.00e-02 | 0.0e+00 | ALDOA,BIRC2,BIRC3,CCND1,CCND2,CCNG1,CD274,CDKN1A,CIDEC,FAS,FASN,FKBP5,IL1RN,JUN,LAMC1,LIMS2,MYO1B,NOX4,PFKFB3,SBK1,SDC4,STAC3 | 378 (20) |
| NCOA1 | -1.00e-02 | transcription regulator | NA | -1.00e-01 | 0.0e+00 | AGL,ALDOA,BTG2,CCND1,CDKN1A,CEBPB,CYP17A1,CYP7A1,DBP,Esrra,FGFR2,HNF1A,IL1RN,LPIN1,NFKBIZ,NOCT,PAWR,PPARD,RB1,SERPINE1 | 320 (21) |
| GDF2 | -2.00e-02 | growth factor | NA | -1.00e-01 | 0.0e+00 | ANKH,CNTF,FAM89A,FASN,GADD45B,ID2,ID3,NRCAM,PIM3,RAMP1,SERPINB9,SLC12A3,SLC3A2,SLC7A5,SOCS2,UNC5B | 17 (2) |
| lovastatin | NA | chemical drug | NA | -1.00e-01 | 0.0e+00 | ADAMTS1,ATF3,CCND1,CDKN1A,CNTF,ENC1,FASN,FDFT1,HMGCS1,IRF1,LDLR,MOG,NOX4,PCSK9,PPARD,RB1,RHOB,SDC4,SERPINE1,TGFB1,TNFRSF11B | 444 (26) |
| Smad | NA | complex | NA | -1.10e-01 | 1.0e-02 | CDKN1A,ID2,ID3,ID4,SERPINE1 | 177 (3) |
| CCN5 | NA | growth factor | NA | -1.10e-01 | 0.0e+00 | CCND1,CLDN1,FOXA1,JUN,SDC4,SERPINE1,TGFB1,XBP1 | 384 (19) |
| NANOG | NA | transcription regulator | NA | -1.10e-01 | 1.0e-02 | CCND2,CDKN1A,FOXA2,GCK,ID2,ID3,ID4,IER5L,IGFBP1,IRF6,LYN,NRIP1,ONECUT1,PRR30,SEC22B | NA |
| IKZF1 | NA | transcription regulator | NA | -1.20e-01 | 0.0e+00 | CCND2,CD79B,CDKN1A,CISH,DTX3L,EIF4E3,FOXO1,IFIT3,IGSF11,IL15RA,LILRB3,LYN,MYO1B,NFKBIZ,NLRP3,NR3C1,PREP,RTP4,SHROOM3,SPSB1,ST3GAL6,TDO2,TENM3 | 240 (7) |
| cholecalciferol | NA | chemical - endogenous mammalian | NA | -1.20e-01 | 0.0e+00 | BRAP,CEBPB,JUN,NDUFAF4,NFYA,PPARGC1A,PPARGC1B,PSAT1,RB1,RGS1,SERPINB8,SERPINE1,TGFB1,TNFRSF11B | 432 (26) |
| RB1 | -6.20e-01 | transcription regulator | NA | -1.20e-01 | 0.0e+00 | ACO2,ALPL,ATF3,ATP1B1,BCL2L11,CCND1,CCNE1,CD274,CDCA4,CDKN1A,CDT1,CLDN3,DDB2,DLAT,DNAJC11,EDNRA,Esrra,FAS,GADD45B,GMPS,GPR157,ID2,JUN,KANK2,LAMC1,MAF,MCM10,MCM8,MUL1,NR4A2,ORC1,PER1,POLD3,PPARGC1A,PPARGC1B,RB1,RECQL4,REEP1,RHOB,SERPINE1,SH3BP2,TGFB1,TMPO,TPST2,UBR7,VRK1 | 360 (18) |
| NCOA2 | -3.10e-01 | transcription regulator | NA | -1.20e-01 | 2.0e-02 | CCND1,CDKN1A,CEBPB,CYP17A1,CYP7A1,FASN,GCK,HMGCS1,HNF1A,IRF1,LDLR,LPIN1,NR4A2,PPP1R3C | NA |
| isoproterenol | NA | chemical drug | NA | -1.30e-01 | 3.0e-02 | AGT,ATF3,AURKA,BCL2L11,CNTF,CREM,DHRS3,JUN,NLRP3,ODC1,PNPLA2,PRKD3,REN,TGFB1 | NA |
| RORA | 4.80e-01 | ligand-dependent nuclear receptor | NA | -1.30e-01 | 0.0e+00 | ADIPOR2,Aox3,ASNS,ATP1B1,B3GALT1,BHMT,CCNE1,CDKN1A,CISH,DHCR24,FASN,FDFT1,GADD45B,GOT1,GSTM4,Hsd3b4 (includes others),IGFBP1,ITPR1,NAT2,NNMT,NOCT,POR,PPARGC1A,PPP1R3C,RDH16,SELENBP1,SLC13A2,SLC16A10,SULT1C3 | 273 (11) |
| GAS2L3 | 2.60e-01 | other | NA | -1.30e-01 | 0.0e+00 | BTG2,CCND2,CCNG1,CDKN1A,FAS,SLC19A2 | NA |
| asoprisnil | NA | chemical drug | NA | -1.30e-01 | 0.0e+00 | EGF,HSD17B2,IL15,MAP3K5,RARRES1,WNT4 | NA |
| SLC16A2 | -7.00e-02 | transporter | NA | -1.30e-01 | 1.0e-02 | CIRBP,DIO3,KLF9,RBM3,SLC7A5,SLCO1B3 | NA |
| LRP5 | -1.00e-02 | transmembrane receptor | NA | -1.30e-01 | 1.0e-02 | FOXA1,FOXA2,GCK,HNF1A,HNF4A,LDLR,LRP2 | 527 (21) |
| EML4-ALK | NA | fusion gene/product | NA | -1.30e-01 | 0.0e+00 | BCL2L11,CD274,CDC14B,CDKN1A,DUSP6,GADD45B,IGFBP1,IL15RA,IL6R,IRF1,NNMT,PIK3R1,PTP4A1,RHOB,SERPINE1,STAT3,TNFAIP3,VCAN | 306 (20) |
| BMI1 | NA | transcription regulator | NA | -1.30e-01 | 0.0e+00 | AURKA,BTG2,CCNE1,CDC14A,CDKN1A,FAS,ID4,P4HA1,PARP9 | 349 (18) |
| mir-155 | NA | microRNA | NA | -1.30e-01 | 0.0e+00 | ALDOA,ARG1,CCND1,CDKN1A,CEBPB,CLDN1,IFIT3,MAF,MX1,S1PR1,SERPINE1,STAT3,TGFB1,TP53INP1,WEE1 | 418 (18) |
| FAS | -8.00e-01 | transmembrane receptor | NA | -1.30e-01 | 0.0e+00 | ARL4A,BIRC2,BIRC3,CDKN1A,CXCL11,DNAH17,EFNA1,FAS,FOXO1,FSCN1,GADD45G,GBP2,IL15RA,IRF1,ITPR1,JUN,LDLR,NECTIN1,NR3C1,NR4A2,P2RY10,PLD1,PPFIA1,PPFIBP2,PSTPIP1,PTP4A1,PTPN1,RGS3,RRAGD,RSAD2,SERPINB9,SERPINE1,SYK,TFRC,TGFB1,TNFAIP3,TNFRSF11B,TNK2 | 362 (14) |
| NR1H2 | 4.00e-02 | ligand-dependent nuclear receptor | NA | -1.40e-01 | 0.0e+00 | AGT,CYP7A1,FASN,FDFT1,GCK,IL1RN,LDLR,PFKFB1,PNPLA2,RB1,REN,SLC16A10,THRB | 349 (22) |
| NOTCH1 | 2.80e-01 | transcription regulator | NA | -1.40e-01 | 1.0e-02 | ALDOA,BIRC2,BIRC3,CCND1,CCND2,CCNE1,CDKN1A,CEBPB,DLL1,DLL4,DNAJA1,EPHA4,FABP7,HSPH1,ID2,IRF1,PFKFB3,RB1,REN,RND3,SERPINE1,TGFB1,WNT4 | 405 (19) |
| BTG2 | 8.90e-01 | transcription regulator | NA | -1.40e-01 | 3.0e-02 | BTG2,CCND1,CCNE1,NOX4,SERPINE1 | NA |
| nitrofurantoin | NA | chemical drug | NA | -1.40e-01 | 0.0e+00 | ADAMTS1,AMACR,AMD1,APEX1,ASL,ASNS,ASS1,BTG2,CCND1,CCNG1,CPT1A,FAS,GTPBP4,HMGCS1,HNF4A,IFRD1,IGFBP1,ODC1,PCYT1A,SELENBP1,SLC34A2 | NA |
| ALB | 1.10e-01 | transporter | NA | -1.50e-01 | 1.0e-02 | AGT,CDKN1A,EDNRA,EDNRB,HNF1A,TGFB1,XBP1 | 502 (26) |
| bis(4-hydroxyphenyl)sulfone | NA | chemical reagent | NA | -1.50e-01 | 1.0e-02 | MTSS1,PCSK6,SNX16,STC1 | NA |
| Cyp2c70 | -6.00e-02 | enzyme | NA | -1.50e-01 | 1.0e-02 | CYP7A1,LDLR,PPARGC1A,TGFB1 | NA |
| ZNF768 | 1.40e-01 | other | NA | -1.50e-01 | 3.0e-02 | AURKA,BTG2,FAS,SERPINE1 | NA |
| Hdac | NA | group | NA | -1.50e-01 | 0.0e+00 | ADAMTS1,ATF3,CCND1,CDKN1A,DLL1,EDNRA,EDNRB,FOXA1,GADD45B,IL6R,JUN,KLF9,LRP2,MEOX2,ONECUT1,PPARGC1A,WNT4 | 423 (22) |
| JAG1 | -5.60e-01 | growth factor | NA | -1.60e-01 | 1.0e-02 | CCND1,CCND2,CDKN1A,CLDN1,DUSP6,GDF15,IGFBP1,TGFB1,WNT4 | 477 (26) |
| arsenite | NA | chemical toxicant | NA | -1.60e-01 | 0.0e+00 | APEX1,CCND1,CDKN1A,FZD1,GCLM,HDAC2,INHBA,IRF1,JUN,NFE2L2,PDSS1,PPP1R3C,SERPINE1,SLC38A2,TGFB1,UGDH | 417 (21) |
| PTPN1 | 6.20e-01 | phosphatase | NA | -1.70e-01 | 0.0e+00 | ADRA1B,EDEM1,FASN,HHEX,IGFALS,NOX4,PIK3R1,PPARGC1A | 399 (20) |
| fludarabine | NA | chemical drug | NA | -1.70e-01 | 1.0e-02 | CCND1,CCNE1,CDKN1A,DDB2,FAS,IRF1 | 397 (27) |
| RPTOR | -1.40e-01 | other | NA | -1.70e-01 | 0.0e+00 | BCL3,CCND1,CCND2,DHCR24,DUSP6,FASN,FDFT1,HIGD1A,HMGCS1,IFI44,Ifi47,IL17RB,JUN,MSMO1,NLRP3,OSCAR,PYCARD,SOS1,SQLE | 400 (21) |
| PP1 | NA | chemical drug | NA | -1.70e-01 | 0.0e+00 | BCL2L11,CCND2,IL1RN,JUN,ODC1,SERPINE1,SIRPA | 378 (21) |
| Hsp27 | NA | group | NA | -1.90e-01 | 1.0e-02 | CCND1,CD274,CDKN1A,IL6R,NOX4,STAT3,TGFB1 | 365 (18) |
| Am 580 | NA | chemical reagent | NA | -1.90e-01 | 3.0e-02 | CPT1A,FASN,FDFT1,HMGCS1,IRF1,SQLE | NA |
| MTOR | 2.00e-02 | kinase | NA | -1.90e-01 | 0.0e+00 | AMACR,BCL2L11,CCND1,CCNE1,CD274,CDKN1A,CEBPB,CHKA,CPT2,CYP17A1,DDIT4,EFNA1,FASN,HNF1A,HSD17B2,HSPH1,IRF1,MADD,MAF,MAP1LC3B,MOG,NOX4,PFKFB2,PPARD,PPARGC1A,PPARGC1B,PPP2CA,RPS18,S1PR1,SEC22B,SLC26A3,STAT3,TCF7L2,TK1,TNFRSF11B,TPPP | 443 (20) |
| estrogen | NA | chemical drug | NA | -1.90e-01 | 0.0e+00 | AGT,AURKA,BCL3,CCND1,CDKN1A,CYP17A1,EGF,FAS,FOXA2,HSPH1,IGFBP1,IHH,JUN,KCNH1,LDLR,MEOX2,NRIP1,PLIN4,S1PR1,SERPINB9,SLC12A3,STAT3,TNFRSF11B,XBP1 | 475 (24) |
| ESRRA | NA | transcription regulator | NA | -1.90e-01 | 2.0e-02 | ARHGAP24,CHKA,CYP17A1,EFNA1,EGF,Esrra,FASN,GOT1,GPR37,HMGCS1,IDH3A,JAM3,KCNJ8,NRIP1,NRP2,PLXND1,PPARGC1A,PPARGC1B,PPP2R2B,UNC5B,XBP1,ZC3H12A | NA |
| PRKN | NA | enzyme | NA | -1.90e-01 | 2.0e-02 | CCND1,CCNE1,CDKN1A,EGF,SERPINE1,TCF7L2,TNFRSF11B,TOMM20,XBP1 | NA |
| TRPC1 | NA | ion channel | NA | -2.00e-01 | 1.0e-02 | CCND1,CCND2,CDKN1A,FOXO1,IGFBP1 | 438 (24) |
| N-[(2Z)-3-(4,5-dihydro-1,3-thiazol-2-yl)-1,3-thiazolidin-2-yl idene]-5H dibenzo[a,d][7]annulen-5-amine | NA | chemical reagent | NA | -2.00e-01 | 1.0e-02 | CEBPB,CRAT,CREM,FASN,HSD17B2,PPARGC1A,SERPINE1,TFRC,UBC | NA |
| piceatannol | NA | chemical - endogenous non-mammalian | NA | -2.00e-01 | 3.0e-02 | BCL2L11,BIRC3,CCND1,CCND2,FAS | NA |
| SKIL | 3.00e-01 | transcription regulator | NA | -2.00e-01 | 5.0e-02 | CDKN1A,DCHS1,FOXA2,SERPINE1,SLC16A6 | NA |
| gemcitabine | NA | chemical drug | NA | -2.00e-01 | 0.0e+00 | BTG2,CCND1,CD274,CDKN1A,CPT1A,EGF,FAS,FASN,JUN,RIPK3,VMP1 | 421 (24) |
| Mek | NA | group | NA | -2.00e-01 | 0.0e+00 | BCL2L11,CCND1,CCND2,CDKN1A,CLDN2,CXCL11,DUSP6,EDEM1,ETV5,EXT1,FASN,GALNT10,GBP2,GDF15,GNL3,ID2,Ifi47,IL15,IRF1,JUN,LAMA3,MAF,MSLN,NOX4,NPC1,PAX8,PPARGC1A,PTTG1IP,RND3,SERPINE1,SLC16A6,TNFAIP3,UNC5B | 424 (23) |
| MAP3K8 | 1.40e-01 | kinase | NA | -2.00e-01 | 0.0e+00 | ARG1,ARRDC3,BIRC3,DOK2,DUSP6,FSCN1,GPR146,INHBA,JUN,PPARGC1B,RGS3,RHOF,RNMT,SBK1,SENP7,SPATS2L,TDRKH | 460 (20) |
| rottlerin | NA | chemical drug | NA | -2.00e-01 | 3.0e-02 | BIRC3,CCND1,CDKN1A,CLDN1,EEF2K,FKBP5,JUN,PLD1 | NA |
| TRAF3 | -3.00e-02 | enzyme | NA | -2.10e-01 | 4.0e-02 | BIRC3,CHKA,FAS,MAP3K14,PPFIBP2,PTK6,TK1,TNFAIP3,XBP1 | NA |
| miR-34a-5p (and other miRNAs w/seed GGCAGUG) | NA | mature microRNA | NA | -2.10e-01 | 2.0e-02 | ATF3,B4GALNT1,CCND1,CCND2,CDKN1A,DLL1,EFHD1,FAM110C,GTF2IRD1,LGALS9B,MCM10,SERPINB8,TP53INP1 | NA |
| FGF2 | 2.50e-01 | growth factor | NA | -2.10e-01 | 0.0e+00 | ACER2,ADGRL2,AGL,BTG2,CCND1,CCND2,CCNE1,CD274,CDKN1A,CIDEC,CNTF,DIO3,DLL1,DLL4,DUSP6,EDNRB,EPHA4,ETV5,FAS,FGFR2,FOXO1,ID2,ID3,INHBA,JUN,MEOX2,NR3C1,NR4A2,ODC1,PTPN1,RB1,SERPINE1,STOM,SYCP3,TAT,TGFB1,WNT4,ZFP57 | 466 (24) |
| cholic acid | NA | chemical - endogenous mammalian | NA | -2.20e-01 | 0.0e+00 | AGT,CCNG1,CIRBP,CYP7A1,EGF,FABP7,FDFT1,LRP2,NR1I2,PPARGC1A,SLCO1B3,SQLE | 374 (18) |
| PG3-Oc | NA | chemical reagent | NA | -2.20e-01 | 0.0e+00 | ACER2,ATF3,CDKN1A,DDB2,FAS,GDF15,TP53INP1 | NA |
| BMPR1A | 2.80e-01 | kinase | NA | -2.20e-01 | 0.0e+00 | CDKN1A,CYP17A1,HHEX,ID3,INHBA,SERPINE1,SOX5,SOX6 | 364 (23) |
| zVAD-FMK | NA | chemical - protease inhibitor | NA | -2.20e-01 | 1.0e-02 | ARG1,BCL2L11,BIRC2,BIRC3,CCNE1,CDKN1A,MAP1LC3B | 390 (22) |
| salirasib | NA | chemical drug | NA | -2.20e-01 | 3.0e-02 | ATF3,BHLHE40,P4HA1,PFKFB3,SERPINE1,STC1 | NA |
| SPHK2 | 2.10e-01 | kinase | NA | -2.20e-01 | 1.0e-02 | CDKN1A,CPT1A,FASN,FGR,LYN | NA |
| Raf | NA | group | NA | -2.20e-01 | 0.0e+00 | BCL2L11,CCND1,CDKN1A,DUSP6,EGF,ETV5,GDF15,ID2,JUN,PPARGC1A,RND3,SLC16A6,TNFAIP3 | 439 (23) |
| EPO | NA | cytokine | NA | -2.30e-01 | 0.0e+00 | ARG1,ATOH8,ATP6V1B2,BCL2L11,BCL3,CA1,CCND2,CDKN1A,CISH,CNTF,DHCR24,FAS,GDF15,ID2,JUN,KPNA2,LDLR,MID1IP1,N4BP2L1,NR3C1,NUPR1,PIK3IP1,REN,SEC22B,SMARCD2,SOCS2,STAT3,TFRC,TNFRSF11B | 350 (20) |
| IGF1 | -2.00e-02 | growth factor | NA | -2.40e-01 | 0.0e+00 | ATL2,BCL2L11,BHLHE40,BIRC3,BTG2,CCND1,CCND2,CCNE1,CCNG1,CDKN1A,CEBPB,CISH,COBL,CYP17A1,DDIT4,DUSP6,EGF,ETV6,FASN,FOXA1,FOXO1,GADD45G,GCK,ID2,IGFBP1,IHH,JUN,MARS2,NFE2L2,NNMT,NOX4,NR3C1,NUPR1,ODC1,PKP2,Rcan1,SERPINE1,SLC25A25,SQLE,TGFB1,TK1,TNFRSF11B,TOMM40,USP2,WEE1,WNT4,XBP1,ZFP36L1 | 582 (23) |
| rotenone | NA | chemical toxicant | NA | -2.40e-01 | 4.0e-02 | AGT,BIRC3,CCND1,GADD45G,NFE2L2,NR4A2,SESN2 | NA |
| NTRK2 | -2.90e-01 | kinase | NA | -2.40e-01 | 0.0e+00 | BCL2L11,CCND1,CCND2,CCNE1,CDKN1A,CEBPB,PIK3R1,PYCARD,RB1,SERPINE1 | 399 (22) |
| deoxycorticosterone acetate/potassium chloride/sodium chloride | NA | chemical reagent | NA | -2.40e-01 | 2.0e-02 | AGT,HNF4A,NOX4,REN,THRB | NA |
| TGFB3 | 1.40e-01 | growth factor | NA | -2.40e-01 | 0.0e+00 | BHLHE40,CCNE1,CDKN1A,JUN,MAPK11,MICAL2,PALLD,PPARGC1A,SERPINE1,SH3PXD2A,TGFB1,TNFRSF11B,TNS1 | 411 (22) |
| caffeic acid phenethyl ester | NA | chemical drug | NA | -2.50e-01 | 1.0e-02 | BIRC3,CCND1,CCNE1,CCNG1,CDKN1A,NFE2L2,PLD1,RB1,RHOB,STAT3,TGFB1 | 411 (24) |
| A2M | 3.20e-01 | transporter | NA | -2.50e-01 | 1.0e-02 | CCND1,FASN,FOXO1,GADD45B,MAP3K5,XBP1 | NA |
| MAP2K6 | 7.70e-01 | kinase | NA | -2.50e-01 | 2.0e-02 | CCND1,CDKN1A,IHH,JUN,LDLR,OSCAR,PPARGC1A,RGS7 | NA |
| amino acids | NA | chemical - endogenous mammalian | NA | -2.60e-01 | 0.0e+00 | ASNS,ELAVL1,FOXA2,IGFBP1,JUN,ODC1,SLC38A2,SLC7A2 | 446 (20) |
| BMP4 | -1.70e-01 | growth factor | NA | -2.60e-01 | 2.0e-02 | CCND1,CCNG1,CDKN1A,CEBPB,CYP17A1,DIO3,EFNA1,FGFR2,ID2,ID3,INHBA,JUN,MAFK,NUPR1,PFKFB3,PPARD,SERPINE1,TNFRSF11B | NA |
| BRCA1 | 9.00e-02 | transcription regulator | NA | -2.60e-01 | 0.0e+00 | BACH1,CARD10,CCND1,CCNE1,CCNG1,Cd24a,CDKN1A,DDB2,DDIT4,ELAVL1,FAS,FKBP5,FOXA1,FOXO1,GADD45B,GDF15,HNRNPD,IFIT3,LAMA3,LPIN1,MX1,NFE2L2,NR3C1,RB1,STC1,VCAN,WEE1 | 426 (19) |
| CLDN7 | -4.00e-02 | other | NA | -2.60e-01 | 1.0e-02 | AGT,B4GALNT1,CA12,CBX2,HELZ2,IFI44,LIMA1,LYSMD2,MX1,NNMT,SLC25A22,TINAGL1 | NA |
| 10E,12Z-octadecadienoic acid | NA | chemical - endogenous mammalian | NA | -2.70e-01 | 0.0e+00 | ATF3,CPT1A,FASN,GDF15,GPRIN3,IL1RN,ITPKA,LDLR,LPIN1,MCM10,NR4A2,PNPLA2,RGS1,SMTNL2,SOX6,TK1,XBP1 | 416 (22) |
| NAMPT | -1.00e-02 | cytokine | NA | -2.70e-01 | 1.0e-02 | AKR1C4,FMO3,GDF15,HSD17B2,IDH3A,JUN,POR,PPARGC1A,RDH16,SOCS2,TGFB1 | 521 (23) |
| TXNIP | 1.50e-01 | other | NA | -2.70e-01 | 0.0e+00 | Acot1,ALDOA,CCND1,CDKN1A,DDIT4,FASN,NLRP3,NOX4,PPARGC1A | 400 (19) |
| STAT5a/b | NA | group | NA | -2.70e-01 | 0.0e+00 | ARG1,BCL2L11,CCND1,CCND2,CDKN1A,CISH,EPHA4,ID2,IGFALS,IRF1,MAF,MYOM1,NIFK,PTGER3,UGP2,WDR3 | 371 (21) |
| GH1 | NA | growth factor | NA | -2.70e-01 | 0.0e+00 | ATF3,CEBPB,CISH,FASN,Hsd3b4 (includes others),ID2,ID3,IGFALS,IGFBP1,JUN,LDLR,SLCO1B3,SOCS2 | 437 (24) |
| 2-amino-5-phosphonovaleric acid | NA | chemical - other | NA | -2.80e-01 | 0.0e+00 | ADAMTS1,ALS2,CRCP,DACT2,DUSP6,EXT1,FOXO1,GADD45B,GADD45G,HDHD3,IFRD1,JUN,NR4A2,NRN1,PER2,PLK3,RASGEF1B,RASL11A,SENP7,SLC25A29,TNFAIP3,ZNF750 | 91 (3) |
| PER2 | -1.32e+00 | transcription regulator | NA | -2.80e-01 | 0.0e+00 | CCND1,CCNE1,DBP,IHH,PER1,PER2 | 233 (13) |
| leucine | NA | chemical - endogenous mammalian | NA | -2.80e-01 | 0.0e+00 | ASNS,ATF3,CDKN1A,CRAT,FASN,HERPUD1,IGFBP1 | 438 (22) |
| FABP1 | -2.00e-01 | transporter | NA | -2.80e-01 | 0.0e+00 | ABHD5,CYP7A1,FASN,GOT1,PNPLA2 | 332 (18) |
| ACE | -1.50e-01 | peptidase | NA | -2.80e-01 | 1.0e-02 | AGT,CEBPB,PREP,REN,SERPINE1 | 167 (7) |
| BRD4 | NA | kinase | NA | -2.80e-01 | 1.0e-02 | BCL3,BHLHE40,BTG2,CCND1,CCND2,CD274,CDKN1A,ETV6,ID2,IL6R,IRF1,SESN2,SLC16A6,SLC7A2,XBP1 | NA |
| NPM1 | 8.00e-02 | transcription regulator | NA | -2.80e-01 | 2.0e-02 | CEBPB,DDB2,DLL1,FAM110C,INHBA,JUN,MTSS1,S1PR2,SDC4,STC1,TNFAIP3,XBP1,ZC3H12A,ZFP36L1 | NA |
| methyl-beta-cyclodextrin | NA | chemical drug | NA | -2.80e-01 | 2.0e-02 | CCND1,CCNE1,FDFT1,LDLR,SERPINE1 | NA |
| MAP3K12 | 4.90e-01 | kinase | NA | -2.80e-01 | 4.0e-02 | JUN,NRN1,RPS18,STAT3 | NA |
| simvastatin | NA | chemical drug | NA | -2.80e-01 | 0.0e+00 | ADAMTS1,ADCYAP1R1,ASL,CCND1,CCND2,CDKN1A,ELAVL1,ENC1,IRF1,LDLR,MAP1LC3B,NRIP1,PCSK9,RHOB,SDC4,SERPINE1,TIMM10,TNFRSF11B,WNT4,ZNF354A | 431 (22) |
| POU5F1 | NA | transcription regulator | NA | -2.80e-01 | 0.0e+00 | BCL2L11,BIRC2,BIRC3,CCND1,CCNF,CD274,CDKN1A,CYP26A1,FAS,FBXO15,FOXA1,FOXA2,GADD45G,GCK,ID3,IER5L,INHBA,IRF6,Oasl2,ONECUT1,PCSK6,PPL,PPP2CA,PYCARD,SIRPA,TGFB1,TGM1,TNFRSF11B,TNFRSF14,WEE1 | 385 (19) |
| HSF1 | 3.30e-01 | transcription regulator | NA | -2.80e-01 | 0.0e+00 | CCDC117,CCNE1,CD274,CEBPB,COBL,DNAJA1,ELAVL1,FASN,HSPH1,INHBA,JUN,LDLR,LRIG1,LSM2,PLIN4,PNPLA2,PPARGC1A,RAD51D,SMTNL2,UBC,VCAN,WWC1,ZFAND2A | 441 (23) |
| L-histidine | NA | chemical - endogenous mammalian | NA | -2.80e-01 | 0.0e+00 | ASNS,ATF3,CEBPB,DDIT4,ELAVL1,HNRNPD,SLC38A2 | 424 (24) |
| GPR39 | -2.00e-01 | G-protein coupled receptor | NA | -2.80e-01 | 1.0e-02 | EGF,INHBA,PNPLA2,SERPINE1 | NA |
| WNT1 | NA | cytokine | NA | -2.80e-01 | 2.0e-02 | CCND1,CCND2,CCNG1,CDKN1A,DLL1,DLL4,GADD45G,HNF1A,HNF4A,ISLR,JUN,SERPINE1 | NA |
| fulvestrant | NA | chemical drug | NA | -2.80e-01 | 0.0e+00 | ADCY9,ASNS,AURKA,CA12,CBS/LOC102724560,CCND1,CCNE1,CDKN1A,CXCL11,CYP17A1,DDIT4,DHCR24,DYNLL1,ID2,IRF1,JUN,LDLR,MAP2K6,MTHFD1,MYO1B,PPME1,PPP1R9B,PTGER3,RB1,RECQL4,RNF4,SERPINB9,SLC7A5,STAT3,STC1,TFRC,TGFB1,TK1,TNFRSF11B,WEE1,WNT4,XBP1 | 434 (21) |
| miR-27a-3p (and other miRNAs w/seed UCACAGU) | NA | mature microRNA | NA | -2.90e-01 | 0.0e+00 | EDNRA,FASN,FOXO1,HNF4A,JUN,ODC1,PNPLA2,THRB,WEE1 | NA |
| LEP | 1.00e-01 | growth factor | NA | -2.90e-01 | 0.0e+00 | ALDOA,ASL,ASS1,CCND1,CDKN1A,CEBPB,CPT1A,CYP17A1,CYP7A1,DFFB,DLL4,DUSP6,EPHX2,FAS,FASN,FGFR2,GCK,IL1RN,IRF1,Irgm1,JUN,LDLR,MAP1LC3B,MSI1,MSMO1,NLRP3,NR3C1,PER2,PNPLA2,PPARGC1A,PPARGC1B,PTPN1,SERPINE1,SLC13A2,STAT3,TGFB1,Tmem18,TNFRSF11B,UGP2 | 537 (24) |
| 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene | NA | chemical toxicant | NA | -2.90e-01 | 0.0e+00 | CCND1,CDKN1A,CPT1A,CYP7A1,FASN,GADD45B,INSIG1,INSIG2,PDE3B,PNPLA2,RARRES1,SLCO1B3,SULT1C3 | 453 (16) |
| KAT2A | -2.70e-01 | enzyme | NA | -2.90e-01 | 1.0e-02 | ADAMTS1,CCND1,CCND2,CCNE1,EDEM1,EFNA5,HDAC2,HNRNPD,JUN,PIK3R1,PPARGC1A,PTPRO | 422 (21) |
| PAF1 | 4.00e-01 | other | NA | -3.00e-01 | 0.0e+00 | ARL4A,BIRC3,HELZ2,IFI44,IFI44L,IFIT3,NFKBIZ,OAS2,SDC4,SERPINE1,ZNFX1 | 179 (7) |
| olanzapine | NA | chemical drug | NA | -3.00e-01 | 0.0e+00 | ATF3,CHST3,DBP,FGFR2,HDAC2,HMGCS1,LDLR,NR4A2,PLA2G4A,SLC25A27,Vmn2r1 | NA |
| HOXA10 | NA | transcription regulator | NA | -3.00e-01 | 1.0e-02 | ALPL,ARL4A,BCL2L11,CDKN1A,CSF3R,DBP,FZD1,ID2,KLF9,MEIS2,PIK3R1,PTGER3,REM1,SOS1,TDO2,WNT4 | NA |
| GLI1 | -2.50e-01 | transcription regulator | NA | -3.10e-01 | 0.0e+00 | ARHGAP29,ATF3,BCL2L11,BIRC3,C1QTNF3,CA12,CAPRIN2,CCND1,CCND2,Cd24a,CDK19,CDKN1A,CMPK2,CTPS1,DBP,DUSP6,ETV5,FAM110C,FAS,FOXA2,FOXO1,GADD45B,GREM2,ID2,ID3,IER5L,IL33,INSIG1,KCNJ8,KLF12,KLF9,LDLR,LZTS1,MAPK11,MICAL2,NREP,PAH,PDZRN3,PPARGC1A,PPIF,PTK6,RHOB,SDC4,SELENBP1,SOCS2,SOWAHC,SOX5,SOX6,SYNE1,TDO2,TNFAIP8L1,TSC22D1,VMP1 | 407 (19) |
| STAT5B | -2.00e-01 | transcription regulator | NA | -3.10e-01 | 0.0e+00 | Acnat1/Acnat2,Acot1,Aox3,BAIAP2,BIRC3,CCDC141,CCND1,CCND2,CCNE1,CDKN1A,CHRNA2,CIRBP,CISH,CYP17A1,DIP2B,FAM89A,FAS,GADD45B,GCK,H2-T22,HAO2,Hsd3b4 (includes others),IGFALS,IRF1,JUN,KLF9,LAMA3,MAF,MTMR11,NNMT,NOX4,NR4A2,NRP2,Oasl2,PDZRN3,PIK3IP1,PPME1,PPP1R3C,RAB30,SLC34A2,SOCS2,STAMBPL1,TNFRSF14,TRIM47 | 410 (22) |
| MAP2K4 | 3.40e-01 | kinase | NA | -3.10e-01 | 0.0e+00 | ATF3,BIRC3,CCND1,CDKN1A,FAS,JUN,PLA2G4A,PPARD,STAT3,TGFB1 | 425 (22) |
| paclitaxel | NA | chemical drug | NA | -3.10e-01 | 0.0e+00 | ATF3,AURKA,BCL2L11,BHLHE40,BIRC3,BTG2,CCND1,CCNG1,CD274,CDKN1A,CTDP1,DCHS1,DUSP6,ETV5,FAS,FMO3,FOXO1,GADD45B,GDF15,IHH,JUN,NREP,RB1,RBM3,REN,STAT3,STC1,TP53INP1,TSC22D1,WNT4 | 364 (19) |
| streptozocin | NA | chemical drug | NA | -3.20e-01 | 0.0e+00 | ADIPOR2,ALPL,ATF3,ATP1B1,CBS/LOC102724560,CCNG1,CDKN1A,CIDEC,CPT1A,CPT2,CREM,CYP7A1,DLL4,EGF,FAS,FASN,FOXA1,GCK,HNF4A,IGFALS,IGFBP1,INSIG2,LMNB1,MAF,MAFB,MAP1LC3B,NFE2L2,NOX4,PPARD,PPARGC1A,SERPINE1,SESN2,SLC12A3,SLC7A2,TAT,TCF7L2,TGFB1,UBC,XBP1 | 452 (25) |
| dextran sulfate | NA | chemical drug | NA | -3.20e-01 | 1.0e-02 | ADAMTS1,AGT,ARG1,AURKA,CCND1,CCNF,CDKN1A,CLDN1,CLDN2,EFNA5,EGF,FANCB,ID3,ISLR,NCAPD2,NLRP3,ODC1,PARP2,RECQL4,REN,S1PR1,SERPINE1,SPON2,STAT3,WNT4 | 449 (23) |
| cytokine | NA | group | NA | -3.20e-01 | 5.0e-02 | BCL3,CCND1,CCNE1,CISH,EFNA1,FAS,IGFBP1,IRF1,JUN,SERPINE1,SOCS2,STAT3 | NA |
| cyclosporin A | NA | biologic drug | NA | -3.30e-01 | 0.0e+00 | AGT,ASNS,ATF3,BCL2L11,BIRC3,CBLB,CCND1,CDKN1A,Ctla2a,CYP7A1,DDIT4,DEXI,EDNRA,EDNRB,EGF,ELL2,FAS,FASN,FDFT1,FKBP5,FOXO1,GTPBP4,HERPUD1,HNF4A,ID3,IGFBP1,ITPR1,JUN,KLRD1,LAMA3,LDLR,LYN,MAF,NR3C1,NRCAM,ODC1,OSCAR,PDE3B,PREP,PRKD3,RBM3,Rcan1,REN,SERPINE1,SLC12A3,SLC34A2,TGFB1 | 444 (26) |
| miR-19b-3p (and other miRNAs w/seed GUGCAAA) | NA | mature microRNA | NA | -3.30e-01 | 0.0e+00 | BCL2L11,CCND1,ITPR1,NR4A2,STAT3 | NA |
| THEM6 | -4.90e-01 | other | NA | -3.30e-01 | 0.0e+00 | ASNS,ATF3,EDEM1,FDFT1,HERPUD1,HMGCS1,MSMO1,SQLE,XBP1 | NA |
| AMH | 7.70e-01 | growth factor | NA | -3.30e-01 | 3.0e-02 | BTG2,CDKN1A,CYP17A1,IRF1 | NA |
| PTHLH | NA | other | NA | -3.40e-01 | 3.0e-02 | ADAMTS1,ADAMTS7,CCND1,CDKN1A,IHH,SERPINE1,TGM1,TNFRSF11B | NA |
| methylselenic acid | NA | chemical reagent | NA | -3.40e-01 | 0.0e+00 | ADAMTS1,ATF3,AURKA,BACH1,BIRC2,BIRC3,CCND1,CDC14B,CDK2AP2,CDKN1A,CHEK2,CREB3L2,DHCR24,DYNLL1,FKBP5,FOXA1,GDF15,GPR37,ID2,ID3,IRF1,JUN,NAT2,NREP,PATZ1,POLA1,PPFIA1,RB1,RHOB,RND3,SEC24D,TNFAIP3,UGDH | 475 (25) |
| SPP1 | 3.60e-01 | cytokine | NA | -3.50e-01 | 1.0e-02 | ARG1,AURKA,BCL2L11,CCND1,CCNE1,CDKN1A,CYP7A1,EGF,FGFR2,INSIG1,JUN,NRCAM,PIK3R1,POR,RB1,SERPINE1,TGFB1 | 463 (22) |
| Sb202190 | NA | chemical drug | NA | -3.50e-01 | 0.0e+00 | CCND1,CCND2,CDKN1A,CEBPB,FGFR2,LDLR,MAPK6,P4HA1,PLA2G4A,PPARGC1A,PPARGC1B,RB1,RHOB,SERPINE1,TGM1 | 412 (20) |
| QKI | NA | other | NA | -3.60e-01 | 5.0e-02 | DACT1,DHCR24,FABP7,FDFT1,HMGCS1,MSMO1,PPARGC1A,PTPRO | NA |
| PER1 | 1.16e+00 | transcription regulator | NA | -3.60e-01 | 0.0e+00 | BCL2L11,CCND1,CCNE1,DBP,IHH,PER1,PER2,SLC12A3 | 290 (17) |
| SHC1 | 1.60e-01 | other | NA | -3.70e-01 | 5.0e-02 | BCL2L11,CDKN1A,KLF11,S1PR1,S1PR2,SDC4,SERPINE1 | NA |
| DNMT3A | -3.00e-02 | enzyme | NA | -3.70e-01 | 0.0e+00 | ATF3,BCL2L11,CD79B,EDNRA,ETV5,FOXA1,FOXO1,IRF1,JUN,LRP2,PPP1R3C,RECQL4,S1PR1,SDC4,SYK,TGFB1,TSC22D1,USP2 | 421 (22) |
| MAP2K7 | 2.80e-01 | kinase | NA | -3.70e-01 | 2.0e-02 | ATF3,BIRC3,CCND1,CDKN1A,FAS,PLA2G4A,RHOB | NA |
| sphingosine-1-phosphate | NA | chemical - endogenous mammalian | NA | -3.80e-01 | 0.0e+00 | ACER2,ACKR4,ATOH8,CCND1,CD274,FAS,HDAC2,ID2,IRF6,JUN,NFE2L2,NRP2,PCSK6,POLG2,PPARGC1B,S1PR1,S1PR2,SERPINE1,TGFB1,TNFRSF11B | 377 (24) |
| PD 169316 | NA | chemical drug | NA | -3.80e-01 | 0.0e+00 | BIRC3,CCND1,CCND2,CDKN1A,MAPK6,PPARGC1A,PPARGC1B | 423 (24) |
| ACTL6A | 3.80e-01 | other | NA | -3.80e-01 | 0.0e+00 | BCL2L11,CCND1,CCND2,CCNG1,CDKN1A,FAS,TP53INP1 | 384 (14) |
| cardiotoxin | NA | chemical - other | NA | -3.80e-01 | 0.0e+00 | CCND1,CCND2,CCNE1,CD180,CNTF,CSF3R,DLL1,DOK2,EDNRB,EGF,FGF11,IL15,IL1RN,IL33,IL6R,INHBA,KPNA2,SERPINE1,STAT3,TGFB1,TNFRSF11B,TNFRSF14,TSC22D1 | NA |
| CYLD-AS1 | NA | other | NA | -3.80e-01 | 1.0e-02 | GCLM,IGFBP1,IRF1,NFE2L2,PAX8,PPARGC1B,TNFAIP8L1,UGDH | NA |
| BAPTA-AM | NA | chemical reagent | NA | -3.80e-01 | 2.0e-02 | ATF3,CDKN1A,CISH,CXCL11,JUN,PPP2CA,SOCS2 | NA |
| CHD8 | 8.00e-02 | enzyme | NA | -3.80e-01 | 2.0e-02 | CD274,DYNLL1,ITSN1,PIK3R1,RHOF,TFRC,VANGL1 | NA |
| folic acid | NA | chemical - endogenous mammalian | NA | -3.80e-01 | 0.0e+00 | CDKN1A,CERS6,FZD1,JUN,LGALS9B,MSI1,NLRP3,NOX4,PYCARD,TGFB1,WNT4 | 407 (22) |
| carboplatin | NA | chemical drug | NA | -3.90e-01 | 4.0e-02 | ASNS,CD274,GTPBP4,IGFBP1,RBM3,SLC34A2 | NA |
| PIK3CA | -2.50e-01 | kinase | NA | -3.90e-01 | 0.0e+00 | ADAMTS1,ATOH8,BIRC3,CCND1,Cd24a,CEBPB,CLDN1,FASN,FOXA2,GCK,IGFBP1,IL33,JUN,SERPINE1,TGFB1,TGM1,TK1 | 429 (23) |
| TFRC | 7.90e-01 | transporter | NA | -3.90e-01 | 0.0e+00 | ATF3,BCL2L11,CDKN1A,DDIT4,GSTT2/GSTT2B,HERPUD1,ID2,JUN,PFKFB3,RGS1,SERPINB8,XBP1 | NA |
| ceruletide | NA | biologic drug | NA | -3.90e-01 | 1.0e-02 | CCNE1,DNAJA1,Fus,GADD45G,HSPH1,IL33,IL6R,IRF1,PPL,SOS1,XBP1 | 213 (11) |
| E2F4 | 1.90e-01 | transcription regulator | NA | -3.90e-01 | 0.0e+00 | BCL2L11,CCND1,CCNE1,CDCA4,CDKN1A,CHEK2,DUOX2,FAS,FDFT1,ID3,MCM10,MTHFD1,ORC1,POLA1,PPARGC1A,PPP1R13B,PPP2R2B,PSAT1,RB1,SERPINE1,SLC3A2,TK1,TMPO,TP53INP1,TUBA3E | 151 (4) |
| VEGFA | -4.20e-01 | growth factor | NA | -3.90e-01 | 1.0e-02 | ABHD5,ADAMTS1,BCL6B,CCND1,CCNE1,CDKN1A,DBT,DLL1,DLL4,ETV5,GART,ID3,ITPR1,MEOX2,NR4A2,PNPLA2,PPARGC1A,SERPINE1,STC1,TBC1D8,TGFB1,TOMM20,UNC5B | NA |
| ANXA2 | -8.00e-02 | other | NA | -3.90e-01 | 2.0e-02 | CDKN1A,FAS,JUN,PCSK9,SESN2 | NA |
| GDF9 | NA | growth factor | NA | -3.90e-01 | 1.0e-02 | CYP17A1,ID2,ID3,INHBA,NRIP1,VCAN | 222 (11) |
| SMAD3 | -5.50e-01 | transcription regulator | NA | -4.00e-01 | 0.0e+00 | ADAMTS1,ALPL,ARHGAP24,BCL2L11,CCND1,CCND2,CCNE1,CDKN1A,CHRDL1,CYP7A1,FASN,FDFT1,FOXO1,GADD45B,HHEX,HNF4A,ID2,ID3,IL15,JUN,LAMC1,LDLR,LGALS9B,NET1,NOX4,POR,PPARD,PPARGC1A,RHOB,S1PR1,SERPINE1,STAT3,TGFB1,VCAN | 456 (23) |
| PAX7 | NA | transcription regulator | NA | -4.10e-01 | 5.0e-02 | ASS1,C1QTNF3,Cd24a,CLDN3,ID2,ID3,MSLN | NA |
| Pdgf (complex) | NA | complex | NA | -4.10e-01 | 0.0e+00 | CCND1,CCND2,CDKN1A,DIO3,FOXO1,INHBA,JUN,LDLR,MEOX2,NOX4,NR4A2,ODC1,PTPN1,SERPINE1,TGFB1 | 422 (20) |
| EGLN | NA | group | NA | -4.10e-01 | 0.0e+00 | DIO3,EFNA1,GPR146,GREM2,GYS1,IGFBP1,PEX11A,PPME1,PPP1R3G,RAB11FIP5,RRAGD,SELENBP1,SERPINA7,SERPINE1,SMTNL2,STC1 | NA |
| IL1 | NA | group | NA | -4.20e-01 | 0.0e+00 | ADAMTS1,BHLHE40,CDKN1A,CPT1A,CXCL11,CYP17A1,CYP7A1,FAS,GCK,GDF15,IGFBP1,IL1RN,IL33,INHBA,IRF1,JUN,LDLR,MAP2K6,NR1I2,NRP2,ODC1,PLA2G4A,PLD1,PPARGC1A,SDC4,SERPINE1,TGFB1,TNFAIP3,TNFRSF11B,VCAN | 416 (18) |
| cytarabine | NA | chemical drug | NA | -4.30e-01 | 0.0e+00 | BCL2L11,CD180,CD274,CDKN1A,FAS,MCC,SESN2,THRB,TP53INP1 | 401 (24) |
| SUPT16H | 2.40e-01 | transcription regulator | NA | -4.30e-01 | 1.0e-02 | CCND1,CCNE1,CDKN1A,CPNE4,DNAH17,EXT1,ID2,PALMD,PLXNA2,SLC1A4,STAC3,TMEM231 | NA |
| TCF3 | 2.00e-01 | transcription regulator | NA | -4.40e-01 | 0.0e+00 | ATF3,ATOH8,AURKA,BACH2,BCL2L11,CCDC117,CCND2,CCNE1,CD200R1L,CD79B,CDKN1A,CGREF1,CREB3L2,EDEM1,FGFR2,FOXO1,GADD45B,GNE,ID2,ID3,IL21R,IRF1,JUN,LMO4,MAF,MSMO1,NUPR1,RCBTB2,S1PR1,SEC24D,SLC7A5,VSIR,XBP1,ZC3H12A | 324 (13) |
| NRAS | 7.00e-02 | enzyme | NA | -4.40e-01 | 1.0e-02 | CCND1,CCNE1,CCNG1,CDKN1A,DUSP6,ETV5,FNDC3A,GALE,GBP2,IL1RN,Irgm1,KLRD1,NFE2L2,RHOB,SARDH,STAT3,WEE1,ZNF703 | 378 (23) |
| ERN1 | -1.60e-01 | kinase | NA | -4.40e-01 | 0.0e+00 | ATF3,CEBPB,CPT1A,CREB3L2,EDEM1,FAS,FASN,FITM2,GOT1,JUN,MAP1LC3B,NOX4,OAS2,SEC22B,SEC24D,TINAGL1,XBP1 | 447 (26) |
| cisplatin | NA | chemical drug | NA | -4.40e-01 | 0.0e+00 | ADAMTS1,ASNS,ATF3,BCL2L11,BIRC2,BIRC3,BTG2,CCND1,CCNG1,CDC14B,CDKN1A,CHEK2,CHKA,CPT1A,CPT2,CROCC,Ctla2a,CYP26A1,DDB2,DDIT4,DHRS3,DUSP6,EEF2K,EFNA1,EGF,FAM117A,FAS,FASN,FAXDC2,GDF15,GTPBP4,HAO2,HMGCS1,ID2,IGFBP1,IL15,INHBA,JUN,KLF12,LMO4,LPIN1,LRIG1,MAP1LC3B,MAT1A,MBNL2,MX1,NOX4,NREP,NRIP1,ODC1,PAWR,PCDH20,PDE3B,PEX6,PLK3,PPARGC1A,PTPRO,RB1,RBM3,RNF144B,SERPINE1,SESN2,SLC34A2,SMOX,SOX6,SPON2,STAT3,TGFB1,TNFAIP3,TNFRSF14,TNK2,TP53INP1,TRPM6,TSC22D1,USP2,WEE1,WNT4 | 426 (16) |
| Tgf beta | NA | group | NA | -4.40e-01 | 0.0e+00 | ALDOA,ANKH,ATOH8,ATP1B1,BACH1,BHLHE40,CCND1,CCND2,CCNE1,CD274,CDKN1A,CEBPB,FSCN1,GADD45B,HAND2,HIF3A,ID2,ID3,ID4,IL1RN,JUN,LAMA3,MADD,MAF,MAFK,NOX4,NR4A2,PDSS1,PPARGC1A,PRELID2,RHOB,SERPINE1,SSBP3,TFRC,TGFB1,TNFRSF11B | 458 (20) |
| LHX1 | -2.00e-01 | transcription regulator | NA | -4.40e-01 | 2.0e-02 | ASS1,ATP1B1,CLDN2,FOXA2,HAO2,HHEX,HNF4A,Hsd3b4 (includes others),LRP2,PAH,PKDCC | NA |
| mir-10 | NA | microRNA | NA | -4.40e-01 | 0.0e+00 | ANKH,ARG1,CXCL11,DRAM2,EDEM1,FKBP5,FLVCR2,FOXA1,IL6R,MAF,MKNK2,NOX4,PPP2CA,RB1,SGPL1 | 422 (22) |
| PROM1 | -6.00e-02 | other | NA | -4.50e-01 | 0.0e+00 | DHCR24,HMGCS1,INSIG1,NR4A2,SQLE | 138 (7) |
| entolimod | NA | biologic drug | NA | -4.50e-01 | 1.0e-02 | ATF3,GDF15,IRF1,NFKBIZ,TNFAIP3 | 138 (7) |
| CDKN2B | 7.00e-02 | transcription regulator | NA | -4.50e-01 | 1.0e-02 | ASNS,ASS1,GOT1,PSAT1,SERPINE1 | 185 (7) |
| RNF181 | -1.20e-01 | enzyme | NA | -4.50e-01 | 1.0e-02 | ONECUT1,PTP4A1,SNX24,TAF1B,ZNF385B | NA |
| MED13 | -2.20e-01 | transcription regulator | NA | -4.50e-01 | 2.0e-02 | AACS,CIDEC,FASN,GYS1,NR4A2,PCSK9 | NA |
| MARK2 | 2.40e-01 | kinase | NA | -4.50e-01 | 2.0e-02 | IL15,IRF1,LMO4,NFKBIZ,RSAD2 | NA |
| ADGRE2 | NA | other | NA | -4.50e-01 | 2.0e-02 | CCND1,CD274,CDKN1A,JUN,TGFB1 | NA |
| PRKCI | -2.80e-01 | kinase | NA | -4.50e-01 | 3.0e-02 | CCND1,CD274,FASN,FOXA2,IRF1 | NA |
| T3-TR-RXR | NA | complex | NA | -4.50e-01 | 4.0e-02 | CYP7A1,FASN,KLF9,LDLR,PDE3B | NA |
| dinoprost | NA | chemical - endogenous mammalian | NA | -4.50e-01 | 0.0e+00 | AKR1C4,CCND1,CCND2,Hsd3b4 (includes others),ID2,ID3,JUN,MAPK6,NR4A2,PLA2G4A,POR,TGFB1 | 349 (22) |
| ELOVL5 | 2.80e-01 | enzyme | NA | -4.60e-01 | 0.0e+00 | ABHD5,Acot1,FASN,FOXO1,INSIG2,PNPLA2,PPARGC1A | 337 (12) |
| IL15 | -9.20e-01 | cytokine | NA | -4.60e-01 | 0.0e+00 | ALDOA,BCL2L11,CBLB,CCND1,CCND2,CD274,CDKN1A,CEBPB,CISH,CPT1A,FAS,FMO3,GNL2,ID4,IL15,IL15RA,IL21R,IRF1,JUN,KLRD1,LYN,MAF,MAPKAPK3,MKNK1,MSLN,MX1,PFKFB2,PFKFB3,PIK3R1,PLA2G4A,PLD1,PPARD,PPARGC1A,PPARGC1B,PTP4A1,S1PR1,SERPINE1,SOCS2,SOS1,TFRC,XBP1,ZFP36L1 | 450 (21) |
| EGOT | NA | other | NA | -4.60e-01 | 1.0e-02 | ITPR1,MX1,OAS2,RSAD2 | NA |
| KDM3A | 3.00e-02 | transcription regulator | NA | -4.70e-01 | 1.0e-02 | CCND1,GDF15,IL33,PPP1R3C,SERPINE1,SLC45A3 | NA |
| MITF | -4.20e-01 | transcription regulator | NA | -4.70e-01 | 0.0e+00 | ACO2,ATP6V1B2,CCNF,CDKN1A,CDT1,CHKA,CREM,EDNRB,HPS4,IL6R,LYST,NCAPD2,NR3C1,OSCAR,PPARGC1A,PPP2CA,RAD51D,RECQL4,RRAGD,SERPINE1,SLC19A2,SOX5,SOX6,ST3GAL6,TNFRSF14 | 319 (13) |
| ERK | NA | group | NA | -4.80e-01 | 0.0e+00 | AGT,BCL2L11,BTG2,CCND1,CCNE1,CDKN1A,DIO3,FAS,FOXO1,GDF15,GOT1,IGFBP1,JUN,LDLR,MAFB,NFE2L2,NFKBIZ,ODC1,PPARD,SERPINE1,VCAN,ZFP36L1 | 395 (18) |
| P2RY2 | 5.50e-01 | G-protein coupled receptor | NA | -4.80e-01 | 0.0e+00 | CCND1,CDKN1A,FOXO1,JUN,NFE2L2,SERPINE1,SESN2 | 426 (24) |
| KLF2 | 8.00e-02 | transcription regulator | NA | -4.80e-01 | 0.0e+00 | ASS1,BCL3,CDKN1A,DLL1,EFNA1,FGR,ID3,IL6R,MAP3K5,RGS3,S1PR1,Serpinb6b,SERPINB9,SERPINE1,STAT3,TFRC,TGFB1,UGDH,WEE1 | 377 (18) |
| urethane | NA | chemical toxicant | NA | -4.80e-01 | 1.0e-02 | ARG1,CCND1,CD274,CDKN1A,RB1 | NA |
| IL31 | NA | other | NA | -4.80e-01 | 1.0e-02 | CISH,EGF,IL33,RB1,SOCS2 | 313 (11) |
| KDM4A | -1.80e-01 | transcription regulator | NA | -4.90e-01 | 0.0e+00 | ALS2,CCND1,CDKN1A,CXCL11,PIM3 | 61 (7) |
| mir-17 | NA | microRNA | NA | -4.90e-01 | 0.0e+00 | BCL2L11,BIRC2,BIRC3,CAPRIN2,CCND1,CDKN1A,CPT1A,FAS,FNDC3A,MAP3K5,PPARGC1A,RB1,S1PR1,STAT3,TNFAIP3,TP53INP1,USP2 | 425 (22) |
| CREBBP | -8.00e-02 | transcription regulator | NA | -4.90e-01 | 0.0e+00 | AGT,ARHGAP24,ASL,CCND1,CCND2,CDKN1A,CYP7A1,DHRS3,HMGCS1,IRF1,IRF6,ITGA9,JUN,LDLR,MAF,NFE2L2,NR3C1,NR4A2,PDE3B,PPARGC1A,PPFIBP2,RB1,REN,RNF157,RNF39,RSAD2,RTP4,SDC4,SPSB1,STOM,TNFAIP1,TNFAIP3 | 457 (26) |
| dalfampridine | NA | chemical drug | NA | -4.90e-01 | 1.0e-02 | ATF3,BTG2,DUSP6,GADD45B,GADD45G,JUN,NR4A2,PFKFB3 | 325 (13) |
| NFKBIA | 2.50e-01 | transcription regulator | NA | -4.90e-01 | 0.0e+00 | BCL3,BIRC2,BIRC3,BTG2,CARD10,CCND1,CCND2,CDKN1A,CEBPB,CITED4,CXCL11,DUSP6,FAS,FSCN1,GADD45B,GADD45G,GBP2,ID3,IL15,IL15RA,IL1RN,IL33,IRF1,ITPR1,JUN,LIMA1,LRIG1,NLRP12,NOCT,PIK3R1,RGS3,RPS18,Rtp3,SDC4,TAT,TFRC,TGFB1,TMPO,TNFAIP3,TNFRSF11B | 298 (12) |
| quercetin | NA | chemical drug | NA | -4.90e-01 | 1.0e-02 | ADGRL2,BHLHE40,BIRC3,CDKN1A,EFNA1,EGF,EPHX2,FASN,FZD1,JUN,LDLR,MAFB,NFE2L2,ODC1,PER2,PLD1,POR,PPARGC1A,SLC16A6,TRPV6 | 348 (23) |
| nitroprusside | NA | chemical drug | NA | -5.00e-01 | 1.0e-02 | DUSP6,FAS,FOXO1,LAMC1,PPARGC1A,SLC1A4,TNFRSF11B | NA |
| ethanol | NA | chemical - endogenous mammalian | NA | -5.00e-01 | 0.0e+00 | ADCYAP1R1,ATF3,BHMT,CCND1,CDKN1A,CEBPB,CPT1A,CYP7A1,DUSP6,EDNRB,ETNPPL,FAS,FASN,GBP2,GCK,GREM2,HAO2,HDAC2,Ifi47,IFIT3,IL15,IL1RN,IL33,JUN,LDLR,LPIN1,MAP1LC3B,MAT1A,MOG,NFE2L2,NR1I2,NR3C1,NRIP1,PCSK9,PLK3,PNPLA2,PPARGC1A,PPP1R3C,PRKAA1,RHOB,RRP12,SERPINE1,SQLE,STAT3,TAT,TGFB1,TLR6,TP53INP1,WEE1 | 492 (26) |
| TP73 | 0.00e+00 | transcription regulator | NA | -5.00e-01 | 0.0e+00 | ATF3,AURKA,BCL2L11,BHLHE40,BIRC2,BTG2,CCNF,CCNG1,Cd24a,CDKN1A,DBP,DDIT4,DHRS3,FAS,FASN,FGFR2,HIVEP1,ID2,LAMA3,LIMA1,LZTS1,MTHFD1,NUPR1,PALLD,PKP2,PPL,PRKAG2,RAD17,RB1,RNF144B,RPRM,SDC4,Serpinb6b,SERPINE1,TGFB1,UBE2D1,VMP1,WNT4 | 433 (23) |
| LIF | 0.00e+00 | cytokine | NA | -5.10e-01 | 0.0e+00 | BCL3,CCND1,CCNE1,CDKN1A,CEBPB,CISH,CYP17A1,CYP26A1,FOXA2,ID2,IRF1,JUN,PIM3,PLD1,PTPN1,SOCS2,STAT3,TNFRSF11B,XBP1,ZFP57 | 436 (24) |
| TCF12 | 2.00e-02 | transcription regulator | NA | -5.10e-01 | 1.0e-02 | CD200R1L,CDKN1A,FOXO1,ID2,ID3,IL21R,IRF1,JUN,LMO4,MAF,S1PR1,TNFAIP1,ZC3H12A | NA |
| STAT5A | -3.80e-01 | transcription regulator | NA | -5.10e-01 | 0.0e+00 | BIRC3,CCND1,CCND2,CCNE1,CDKN1A,CEBPB,CEMIP,CISH,FAS,FASN,FOXA1,GADD45G,GALC,ID2,IGFALS,IL6R,IRF1,MAF,NR4A2,ONECUT1,PPFIBP2,PTK6,RNF39,SELENBP1,SETBP1,SLC34A2,SOCS2,TNFRSF14,UGP2 | 447 (24) |
| RELA | 8.00e-02 | transcription regulator | NA | -5.10e-01 | 0.0e+00 | AGT,BACH2,BCL2L11,BCL3,BHLHE40,BIRC2,BIRC3,BTG2,CBS/LOC102724560,CCND1,CD274,CDC14A,CDKN1A,CEBPB,CXCL11,CYP17A1,FAS,FSCN1,GDF15,GPRIN3,HNF4A,IL15RA,IL1RN,IRF1,IRF2BP2,JUN,LYN,LYST,NFE2L2,NR4A2,OAS2,PLD1,PLK3,RGS1,SDC4,TGFB1,TNFAIP3,TNFRSF11B | 397 (13) |
| NR1H4 | -1.00e-01 | ligand-dependent nuclear receptor | NA | -5.10e-01 | 0.0e+00 | ABHD5,BAAT,CCNE1,CEBPB,CPT2,CYP7A1,FABP7,FAS,FASN,FOXA2,GCLM,HNF1A,HNF4A,LDLR,NR1I2,NR3C1,PPARGC1A,PPARGC1B,S1PR1,SLCO1B3,TGFB1,TK1 | 429 (25) |
| NGF | -5.20e-01 | growth factor | NA | -5.10e-01 | 0.0e+00 | ACER2,ADGRL2,AGL,ATF3,BCL2L11,BTG2,CCND1,CDKN1A,DUSP6,EPHA4,ETV5,FAS,GADD45G,ID3,IFRD1,JUN,LDLR,MAFK,PLA2G4A,PLK3,PPP2R2B,REN,S1PR2,STAT3,STOM,TGFB1,UNC5C,WNT4,XBP1 | 489 (23) |
| USF1 | -4.10e-01 | transcription regulator | NA | -5.20e-01 | 0.0e+00 | AGT,CBS/LOC102724560,CPT1A,FASN,IGFBP1,LDLR,P4HA1,REN,SERPINE1,TGFB1,TNFAIP3 | 292 (12) |
| RMRP | NA | other | NA | -5.20e-01 | 1.0e-02 | ALPL,BTG2,CDKN1A,RSAD2 | NA |
| FOXM1 | 4.60e-01 | transcription regulator | NA | -5.20e-01 | 2.0e-02 | AURKA,CCND1,CCND2,CCNE1,CCNF,CDKN1A,CYP7A1,FOXA1,FZD1,IL1RN,JUN,MCM8,STAT3,VCAN | NA |
| CL 316243 | NA | chemical drug | NA | -5.20e-01 | 4.0e-02 | ATF3,FASN,GCLM,IL17RB,PPARGC1A | NA |
| adavosertib | NA | chemical drug | NA | -5.30e-01 | 3.0e-02 | AURKA,CXCL11,IL15RA,IRF1,MAPK11,MX1,TLR6,TNFAIP3,TNFRSF11B | NA |
| glycine | NA | chemical - endogenous mammalian | NA | -5.30e-01 | 0.0e+00 | ASNS,CCND1,CCNE1,CDKN1A,ODC1,PSAT1 | 424 (25) |
| GATA1 | NA | transcription regulator | NA | -5.30e-01 | 3.0e-02 | BACH2,BCL2L11,BTG2,CA1,CCND1,CCND2,CDKN1A,CREM,GART,HHEX,IL6R,LMO4,MAP3K5,MTHFD1,NR4A2,PLXNA2,SLC3A2,SOX6,SSBP3,ST3GAL6,TFRC | NA |
| RRAS2 | -5.00e-01 | enzyme | NA | -5.40e-01 | 0.0e+00 | ACER2,ADRA1B,CLDN1,CLDN14,FSCN1,IFI44L,MSLN,RGS1,RSAD2,RTP4,SERPINB8,SERPINE1,TNFAIP3,VCAN | NA |
| SREBF1 | -1.50e-01 | transcription regulator | NA | -5.40e-01 | 0.0e+00 | AACS,ALDOA,BHLHE40,CDKN1A,CEBPB,CYP7A1,ETHE1,FABP7,FAS,FASN,FDFT1,FOXO1,GCK,HMGCS1,HNF4A,INSIG1,LDLR,LPIN1,MAT1A,MSMO1,NPC1,NUPR1,PCSK9,PCYT1A,PLEKHA4,PPCS,SERPINE1,SQLE,TGFB1 | 308 (20) |
| TEAD1 | 3.00e-01 | transcription regulator | NA | -5.40e-01 | 3.0e-02 | CCND1,CDKN1A,CPT2,EDNRA,GPR37,MSLN,NFKBIZ,NRXN2,PPARD,PPARGC1A,PPARGC1B,PTPRO,RB1 | NA |
| OGA | NA | enzyme | NA | -5.50e-01 | 0.0e+00 | ACO2,ADGRG2,ADGRL2,ARHGAP29,ASS1,BACH1,CCND1,Cd24a,CDCA4,CDKN1A,CEBPB,CIAPIN1,CLDN1,CREB3L2,EPHA4,FABP7,FAS,FDFT1,FSCN1,GADD45G,GNE,GTF2IRD1,HIGD1A,HMGCS1,IDH3A,IFIT3,IL21R,IL6R,JUN,LRIG1,MSMO1,PIK3R1,PLA2G4A,RB1,RHOB,SERPINB9,SLC2A9,SOCS2,TGFB1,TNFRSF11B | 467 (24) |
| sirolimus | NA | chemical drug | NA | -5.50e-01 | 0.0e+00 | ARG1,ASNS,ASS1,ATP6V1B2,AURKA,BCL2L11,BCL3,CCND1,CCND2,CCNE1,CCNF,CD274,CDKN1A,CEBPB,CHRNA2,CRAT,DDIT4,DOT1L,FAS,FASN,FSCN1,GALC,ID2,IGFBP1,IL33,JUN,LPIN1,MAF,MAP1LC3B,NLRP3,NR3C1,ODC1,OSCAR,PARP14,PFKFB2,PIK3R1,PPARD,PPARGC1A,PTP4A1,RPS18,SERPINE1,SLC3A2,SLC7A5,SQLE,TGFB1,TMPO,TNFAIP1,TNFRSF11B,TP53INP1,VMP1,XBP1 | 449 (23) |
| DDB1 | 5.00e-02 | other | NA | -5.60e-01 | 1.0e-02 | BTG2,CDKN1A,CEBPB,ID2,ID3 | NA |
| NOX4 | -6.80e-01 | enzyme | NA | -5.60e-01 | 4.0e-02 | AGT,BCL2L11,CDKN1A,NFE2L2,NOX4,SERPINE1 | NA |
| Insulin | NA | group | NA | -5.70e-01 | 0.0e+00 | Acot1,ADIPOR2,AGT,ALDOA,ARRDC3,ATF3,CCND1,CCNE1,CDKN1A,CEBPB,CIDEC,CRAT,CYP17A1,CYP7A1,DDIT4,DYNLL1,FASN,FDFT1,FOXA1,FOXA2,FOXO1,GCK,HIF3A,HMGCS1,HNF1A,HNF4A,IFIT3,IGFALS,IGFBP1,INHBA,INSIG1,INSIG2,JUN,LDLR,LPIN1,MAT1A,NLRP3,NR3C1,NR4A2,ODC1,PCSK9,PER1,PER2,PFKFB3,PIK3R1,PNPLA2,PPARD,PPARGC1A,PPARGC1B,PYCARD,REN,SERPINE1,SLC25A27,SLC38A2,SOCS2,SQLE,STAT3,TAT,TCF7L2,TGFB1,WNT4,XBP1 | 467 (24) |
| NEUROG3 | NA | transcription regulator | NA | -5.70e-01 | 2.0e-02 | AGT,Cd24a,CDKN1A,DLL1,DLL4,FASN,GCK,HHEX,RHOB,TDO2 | NA |
| STAT6 | 1.60e-01 | transcription regulator | NA | -5.70e-01 | 0.0e+00 | Acot1,ARG1,ASS1,BCL3,BIRC2,CCDC86,CCND2,Cd24a,CD79B,CDKN1A,CIDEC,CISH,CLDN2,CMPK2,CPT1A,CYTH1,DENND4A,DUOX2,EXT1,FASN,FKBP5,FNIP2,FSCN1,GADD45B,GADD45G,GBP2,GNA14,GNA15,H2-T22,IFI44,IFI44L,IFIT3,Igtp,IL15,IL1RN,IL33,IRF1,Irgm1,MAF,MAP3K5,PLD1,PNPLA2,PPARGC1A,PSTPIP1,RAB30,RIPK3,SELENBP1,SERPINE1,SLC25A25,SOCS2,SYK,TGFB1,USP2,XBP1,ZNF608 | 420 (19) |
| SPHK1 | 1.60e-01 | kinase | NA | -5.80e-01 | 0.0e+00 | BCL2L11,BIRC2,BIRC3,CCND1,CDKN1A,IL33,JUN,MAP2K6,SERPINE1 | 425 (22) |
| MAPK9 | 1.00e-02 | kinase | NA | -5.80e-01 | 0.0e+00 | BAAT,BCL2L11,BIRC3,CDKN1A,CDT1,CEBPB,CIDEC,EGF,FAS,FASN,GADD45B,HMGCS1,IL15RA,JUN,PARP14,PLA2G4A,TNFAIP3 | 414 (21) |
| SKIC2 | NA | enzyme | NA | -5.80e-01 | 0.0e+00 | ALDOA,ASNS,BHLHE40,CCNG1,DDIT4,GOT1,IL33,P4HA1,SLC7A5,SQLE,STC1,TFRC | NA |
| FOXL2 | NA | transcription regulator | NA | -5.80e-01 | 1.0e-02 | ATF3,CYP17A1,ETV6,FAS,INHBA,NFE2L2,PPARGC1A,S1PR1,TNFAIP3 | NA |
| Fcer1 | NA | complex | NA | -5.80e-01 | 2.0e-02 | DUSP6,IL1RN,IL33,INHBA,ITPR1,JUN,S1PR2 | NA |
| curcumin | NA | chemical drug | NA | -5.80e-01 | 5.0e-02 | BANP,BCL2L11,BIRC2,BIRC3,CCND1,CCND2,CCNE1,CDC14B,CDKN1A,CEBPB,ELAVL1,FAS,GCLM,HDAC2,JUN,KLF9,MTHFD1,NFE2L2,PDE3B,PNPLA2,PPARGC1A,SERPINE1,STAT3,TFRC,WEE1 | NA |
| IL5 | NA | cytokine | NA | -5.80e-01 | 0.0e+00 | ALDOA,ASNS,ASS1,ATP1B1,BCL3,BIRC2,CCND2,CCNE1,CDKN1A,CISH,CSF3R,DUSP6,ELL2,FAS,GADD45G,GBP2,GCLM,GSTT2/GSTT2B,HIGD1A,HSPH1,IL6R,LIMK2,LMNB1,MAPK6,MKNK1,P4HA1,PPIF,PSAT1,RBM3,SLC7A5,SOCS2,TGFB1,XBP1 | 444 (22) |
| ESR1 | -4.70e-01 | ligand-dependent nuclear receptor | NA | -5.80e-01 | 0.0e+00 | AASS,AGT,APEX1,ARRDC3,ASS1,ATF3,ATP1B1,AURKA,BCL2L11,BIRC3,BRAP,BRWD1,CA12,CCND1,CCNE1,CCNG1,CDKN1A,CEBPB,CHEK2,CISH,CLDN1,CLDN2,COBL,CYP17A1,CYP7A1,DDB2,DDIT4,DHCR24,DLL1,EEF2K,EFNA1,EGF,FAS,FASN,FGFR2,FOXA1,FOXO1,GADD45B,GADD45G,GDF15,GPR37,HIP1R,HNRNPD,HSPH1,IFI44,IFI44L,IFRD1,IRF1,JUN,LDLR,LIMA1,MADD,MAP2K6,MAP3K14,MAP3K9,MAPK11,MX1,NFYB,NRCAM,NRIP1,NUP42,PALLD,PDE7A,PLXNA2,POLA1,POLR3A,POR,PPARD,PPARGC1A,PPP1R3C,PPP1R9B,PRKAA1,PRKD3,PSAT1,PTGER3,PTTG1IP,RB1,RDH16,REN,RGS3,RND3,RPRM,RSAD2,RTP4,SAMD11,SDCCAG8,SERPINB9,SERPINE1,SHANK3,SLC1A4,SLC38A2,SLC3A2,SLC7A2,SLC7A5,SOCS2,SOS1,STAT3,TCF7L2,TDO2,TFRC,TGFB1,THRB,TMPO,TNFAIP3,TNFAIP8L1,TNFRSF11B,UGP2,UNC119,WEE1,WNT4,XBP1,ZNF703 | 464 (21) |
| salmonella minnesota R595 lipopolysaccharides | NA | chemical - endogenous non-mammalian | NA | -5.80e-01 | 1.0e-02 | BCL3,CMPK2,EDNRB,GDF15,IRF1,JUN,NFKBIZ,RSAD2,SERPINE1,SLC7A2,TNFAIP3,TSC22D1 | 394 (19) |
| CpG oligonucleotide | NA | chemical drug | NA | -5.90e-01 | 0.0e+00 | CD274,CEBPB,DLL4,FAS,IFIT3,IL15,IL33,LYN,NFKBIZ,NR1I2,Oas1b,OAS2,Oasl2,SERPINE1,SLC7A5,SYK,TFRC | 366 (18) |
| geranylgeranylacetone | NA | chemical drug | NA | -5.90e-01 | 0.0e+00 | HSPH1,MX1,NPC1,STAT3 | 29 (3) |
| AKT1 | 7.00e-02 | kinase | NA | -6.00e-01 | 0.0e+00 | ANKH,ASS1,BCL2L11,BIRC3,CCND1,CCND2,CCNE1,CDKN1A,CISH,CYP7A1,FAS,FASN,FOXO1,GCK,GCLM,GDF15,HMGCS1,IGFBP1,KLF15,MSMO1,NFE2L2,NOX4,PEX11A,PIK3R1,PLA2G4A,PPARGC1A,RAMP1,REN,RHOB,SERPINE1,SLC3A2,TK1,UNC5B,VCAN | 535 (25) |
| TLR2 | -4.00e-01 | transmembrane receptor | NA | -6.00e-01 | 3.0e-02 | ARG1,ATF3,CDKN1A,CEBPB,CISH,FOXO1,IL15,IL15RA,IL1RN,IL33,IRF1,MX1,NLRP12,TGFB1,XBP1 | NA |
| quizartinib | NA | chemical drug | NA | -6.00e-01 | 0.0e+00 | CBS/LOC102724560,CCND2,DDIT4,FGF11,GADD45G | NA |
| carbon tetrachloride | NA | chemical toxicant | NA | -6.00e-01 | 0.0e+00 | ASS1,ATF3,BCL2L11,BIRC3,CCND2,CDKN1A,CEBPB,EGF,FOXA1,GADD45B,GDF15,IGFBP1,JUN,ODC1,PPARD,PTP4A1,RB1,RIPK3,S1PR2,SLCO1B3,TGFB1 | 487 (24) |
| FZR1 | 2.90e-01 | kinase | NA | -6.00e-01 | 0.0e+00 | CCND1,CCNE1,PFKFB3,RNF157,TK1 | 260 (13) |
| TGM2 | -2.80e-01 | enzyme | NA | -6.00e-01 | 2.0e-02 | ALPL,BIRC3,BTG2,CCND1,CD101,IFIT3,MAFB,OAS2,PARP14,PARP9,POR,SEMA6B,SIRPA,SLC25A15,SLC7A2,TGFB1,TNFRSF11B,WDR3 | NA |
| FOXA1 | -8.90e-01 | transcription regulator | NA | -6.00e-01 | 0.0e+00 | CDKN1A,DDIT4,EFHD1,FOXA1,FOXA2,GBP2,HNF1A,HNF4A,IGFBP1,LYN,NR4A2,NRIP1,PFKFB1,RPRM,SLC10A6,SPSB1,TAT,XBP1 | 430 (20) |
| PP2/AG1879 tyrosine kinase inhibitor | NA | chemical drug | NA | -6.10e-01 | 4.0e-02 | AGT,BCL2L11,BIRC3,CDKN1A,FGR,LYN,PER1,SERPINE1 | NA |
| miR-223-3p (miRNAs w/seed GUCAGUU) | NA | mature microRNA | NA | -6.10e-01 | 0.0e+00 | CCND1,CCNE1,FOXO1,NLRP3,RHOB,SOX6,STAT3 | 308 (13) |
| SATB1 | -3.00e-02 | transcription regulator | NA | -6.10e-01 | 0.0e+00 | CCND1,CDK19,CDKN1A,CSF3R,FOXJ3,GADD45B,GDF15,GTF2E1,HELZ2,ID3,IL17RB,MAF,NFE2L2,NR4A2,PIK3IP1,RB1,RGS1,S1PR1 | 360 (17) |
| PTGS2 | -2.60e-01 | enzyme | NA | -6.10e-01 | 1.0e-02 | ARG1,BIRC3,CCND1,CCNE1,CD274,CDKN1A,CHKA,DYNLL1,EDNRA,FAS,IRX1,NFE2L2,NR4A2,PLA2G4A,PTGER3,PYCARD,SOCS2,STC1,TFRC,TGFB1 | 378 (18) |
| SMAD2 | -2.00e-01 | transcription regulator | NA | -6.10e-01 | 2.0e-02 | ALPL,BCL2L11,CDKN1A,FDFT1,GADD45B,HHEX,IL6R,IRX1,NET1,S1PR1,SERPINE1 | NA |
| H89 | NA | chemical drug | NA | -6.20e-01 | 0.0e+00 | ALPL,CCND1,CDKN1A,CEBPB,CLCF1,CNTF,CREM,CYP17A1,IGFBP1,JUN,NR4A2,PDE3B,PLA2G4A,PLD1,PPARD,PPARGC1A,REN,SERPINE1 | 406 (21) |
| NPC1 | -1.01e+00 | transporter | NA | -6.20e-01 | 0.0e+00 | ACKR4,AKR1C4,ALPL,ATP6V1B2,CCND1,CD79B,CHKA,CYP7A1,HMGCS1,ITPR1,LDLR,NPC1,PCSK9,PLIN4,STAT3,TGFB1,XBP1 | 284 (19) |
| PRKACA | -1.70e-01 | kinase | NA | -6.20e-01 | 0.0e+00 | BCL2L11,CCND1,CCND2,CEBPB,CREM,CYP17A1,ID2 | 299 (18) |
| Fc gamma receptor | NA | group | NA | -6.20e-01 | 1.0e-02 | CCND1,CCNE1,CDKN1A,TGFB1,TNFAIP3 | NA |
| CRNDE | NA | other | NA | -6.20e-01 | 2.0e-02 | ABL2,CDKN1A,DUSP6,GADD45B,TGFB1 | NA |
| FGF19 | NA | growth factor | NA | -6.30e-01 | 2.0e-02 | CCND1,CYP17A1,CYP7A1,FASN,GCK,IGFBP1,IL1RN,PPARGC1B,SQLE | NA |
| ACOX1 | 1.80e-01 | enzyme | NA | -6.30e-01 | 0.0e+00 | ACER2,ADAMTS1,AKR1C4,BAAT,CDKN1A,CRAT,CYP26A1,FASN,GOT1,IGFBP1,MBL2,NFE2L2,NUPR1,PAH,PALMD,PEX11A,RBM3,SELENBP1,SLC22A25,UPP2,XBP1 | 149 (7) |
| GNAS | 5.00e-02 | enzyme | NA | -6.30e-01 | 0.0e+00 | ADAMTS1,ALPL,ANKH,ATF3,BACH2,CDT1,CREM,CYTIP,DENND4A,DTX4,FASN,GADD45G,GOT1,NR4A2,P2RY10,PDE3B,PLA2G4A,PPARGC1A,STAT3,SYK,TSC22D1 | 348 (21) |
| laquinimod | NA | chemical drug | NA | -6.30e-01 | 3.0e-02 | Aox3,FKBP5,PALMD,PPP1R3C,PPP1R3G,RUSC2,SERPINB8,STBD1,SYT15,WNT4 | NA |
| dibutyl phthalate | NA | chemical toxicant | NA | -6.30e-01 | 1.0e-02 | CYP17A1,JUN,NFE2L2,POR,SERPINE1 | 447 (22) |
| IL1A | -3.90e-01 | cytokine | NA | -6.30e-01 | 0.0e+00 | ADAMTS1,ATF3,BCL3,BIRC2,BIRC3,CD274,CDKN1A,CYP17A1,FAS,IL1RN,INHBA,IRF1,JUN,NFKBIZ,NR3C1,PLA2G4A,SERPINE1,STAT3,TGFB1,TK1,TNFAIP3,TNFRSF11B,ZC3H12A | 428 (18) |
| ERK1/2 | NA | group | NA | -6.40e-01 | 1.0e-02 | ALPL,BCL2L11,BHMT,BIRC2,BIRC3,CCND1,CCND2,CDKN1A,CEBPB,CYP17A1,CYP7A1,FGFR2,FKBP5,FOXO1,FZD1,ID3,JUN,LDLR,MKNK1,NOX4,RB1,SERPINE1,UNC119,VCAN | 437 (20) |
| mir-34 | NA | microRNA | NA | -6.40e-01 | 2.0e-02 | BIRC3,CCND1,CCND2,CCNE1,DLL1,DNAH6,KCNH1,LYST,NRIP1,PFKFB3 | NA |
| YAP1 | NA | transcription regulator | NA | -6.40e-01 | 0.0e+00 | ADAMTS1,ADGB,ARG1,BCL2L11,CCND1,CCNF,CD274,CDKN1A,CEP85,CLDN2,CPT1A,CPT2,CYTIP,FAS,FASN,GDF15,HMGCS1,ID2,INF2,INHBA,ITPR1,LAMC1,LMNB1,MAPK11,MSLN,NUPR1,P4HA1,PDE3B,POLA1,PTPN1,RAC3,RPS18,SERPINE1,SYK,TBC1D2,TFRC,TGFB1,TK1,UGP2,WWC1 | 393 (22) |
| STUB1 | 0.00e+00 | enzyme | NA | -6.40e-01 | 2.0e-02 | CD274,CDKN1A,FOXO1,MAP3K14,RB1,RIPK3,TGFB1 | NA |
| MTTP | -5.00e-02 | transporter | NA | -6.40e-01 | 3.0e-02 | CIDEC,CPT1A,GOT1,JUN,XBP1 | NA |
| E2F2 | 5.20e-01 | transcription regulator | NA | -6.50e-01 | 0.0e+00 | CCND1,CCNE1,CDCA4,CDKN1A,CPT2,FGFR2,MCM10,ORC1,POLA1,SERPINE1 | 393 (20) |
| WDR77 | 7.00e-01 | transcription regulator | NA | -6.50e-01 | 0.0e+00 | Igtp,PTK6,SGK2,SLC26A3,TGFB1 | NA |
| MLX | 5.60e-01 | transcription regulator | NA | -6.50e-01 | 0.0e+00 | ATF3,BCL2L11,CPT1A,FAS,FASN,IL1RN,MID1IP1,WNT4 | 211 (7) |
| potassium chloride | NA | chemical drug | NA | -6.50e-01 | 0.0e+00 | ATF3,ATP1B1,ATP2B2,BCL2L11,BTG2,CCNE1,FGFR2,HERPUD1,ID3,IGFBP1,JUN,NR3C1,NR4A2,ODC1,PIK3R1,PIM3,RB1,SLC12A3,TRPV6,UNC5B,XBP1 | 473 (25) |
| CRY2 | 5.80e-01 | enzyme | NA | -6.60e-01 | 0.0e+00 | DBP,IHH,PER1,PER2 | 187 (11) |
| CCND1 | -1.03e+00 | transcription regulator | NA | -6.60e-01 | 0.0e+00 | AURKA,BRWD1,CCND1,CCND2,CCNE1,CDKN1A,DHCR24,ELAVL1,HACL1,ID3,MAP3K5,MCM10,MEIS2,MORC4,PAH,PCYT1A,POLD3,PPCS,RB1,SELENBP1,SRGAP2,STBD1,STOM,TBCK,THNSL1,TOR3A,TP53INP1 | 318 (17) |
| UBE2I | 1.80e-01 | enzyme | NA | -6.60e-01 | 1.0e-02 | CCND1,CPT1A,CYP17A1,IRF1,PPARGC1A,XBP1 | 487 (22) |
| bicuculline | NA | chemical - endogenous non-mammalian | NA | -6.60e-01 | 1.0e-02 | ATF3,BTG2,DUSP6,GADD45B,GADD45G,JUN,NR4A2,PFKFB3 | 418 (19) |
| TRIM37 | 1.00e-01 | enzyme | NA | -6.60e-01 | 0.0e+00 | CA12,CDT1,CLDN1,FOXA1,PARP9,PAWR,TGFB1 | 335 (12) |
| CCN2 | NA | growth factor | NA | -6.60e-01 | 1.0e-02 | ADAMTS1,BIRC2,CCND1,CYP17A1,JUN,MBNL2,P4HA1,PDE7A,SDC4,SERPINE1,TGFB1 | NA |
| azoxymethane | NA | chemical toxicant | NA | -6.70e-01 | 1.0e-02 | AGT,CCND1,CDKN1A,FANCB,ISLR,ODC1,PARP2,REN,STAT3 | NA |
| MIR17HG | NA | other | NA | -6.80e-01 | 3.0e-02 | ALPL,BCL2L11,CCND1,CCNE1,CD274,CDKN1A,DCHS1,DLL1,FZD1,TNFAIP3,ZNF703 | NA |
| tyrphostin AG490 | NA | chemical drug | NA | -6.80e-01 | 4.0e-02 | AGT,BIRC3,CD274,CDKN1A,DUOX2,IRF1,LYN,OSCAR,STAT3 | NA |
| miR-17-5p (and other miRNAs w/seed AAAGUGC) | NA | mature microRNA | NA | -6.80e-01 | 0.0e+00 | BCL2L11,CCND1,CCND2,CCNE1,CD274,CDKN1A,PAX8,RB1,S1PR1,SLC16A6,STAT3,TBC1D2 | 320 (14) |
| TNFSF13B | 3.00e-02 | cytokine | NA | -6.90e-01 | 0.0e+00 | ASS1,BCL2L11,CCND2,Cd24a,CD274,EFNA5,FAS,FGR,FOXO1,IL15,IL1RN,INHBA,JUN,MAP3K14,NR4A2,UNC5C | 398 (16) |
| PLCL1 | -4.10e-01 | enzyme | NA | -6.90e-01 | 0.0e+00 | BCL2L11,IGFBP1,PPARD,PPARGC1A,WNT4 | 426 (22) |
| miR-21-5p (and other miRNAs w/seed AGCUUAU) | NA | mature microRNA | NA | -6.90e-01 | 0.0e+00 | BTG2,CD274,CDKN1A,FAS,IL6R,PIK3R1,PRRG4,SLC16A10,SOX5,STAT3,TNFRSF11B | 397 (18) |
| PDX1 | NA | transcription regulator | NA | -7.00e-01 | 0.0e+00 | ASNS,ATF3,CCND1,CPT2,CREM,DUSP6,EFNA1,GCK,GCLM,GOT1,HNF4A,ID2,ID3,INSIG1,JUN,MPHOSPH10,PTGER3,PTP4A1,RSAD2,SSBP3,TCF7L2 | 427 (20) |
| CD38 | 3.20e-01 | enzyme | NA | -7.00e-01 | 0.0e+00 | ALDOA,ASNS,ASS1,ATP1B1,CCND2,CCNE1,CISH,ELL2,GADD45G,GBP2,GSTT2/GSTT2B,HIGD1A,IL6R,LGALSL,NOX4,P4HA1,PPARGC1A,PSAT1,SLC7A5,SOCS2,TGFB1,XBP1 | 448 (23) |
| iron | NA | chemical - endogenous mammalian | NA | -7.00e-01 | 0.0e+00 | CCND1,CCND2,CCNE1,CDKN1A,GADD45B,GADD45G,NFYA,TFRC,UBE2D1 | 426 (25) |
| tanespimycin | NA | chemical drug | NA | -7.00e-01 | 1.0e-02 | BIRC3,CCND1,CDKN1A,FAS,FASN,FDFT1,HMGCS1,IL6R,JUN,LYN,SERPINE1,STAT3,TNFAIP3 | 425 (24) |
| ASCL1 | NA | transcription regulator | NA | -7.00e-01 | 0.0e+00 | CDKN1A,DLL1,DLL4,GADD45G,ID3,PAX8,PCSK6,PLXNA2,PRMT2,SEMA6B,THRB | NA |
| bexarotene | NA | chemical drug | NA | -7.10e-01 | 0.0e+00 | ASNS,CCND1,CYP26A1,DDIT4,DHRS3,EFNA5,FABP7,HERPUD1,IL15,ITPR1,MAF,NR1I2,NR4A2,NRP2,ODC1,PCSK9,PER2,PIK3R1,PTPRO,SLC7A5,TGFB1,XBP1 | 460 (22) |
| ARHGAP21 | 1.70e-01 | other | NA | -7.10e-01 | 0.0e+00 | IFIT3,IL15,IL15RA,IRF1,LMO4,Mx2,NFKBIZ,TSC22D1 | NA |
| IL4R | -3.40e-01 | transmembrane receptor | NA | -7.10e-01 | 3.0e-02 | ADGRL2,ARG1,CACNB2,CEBPB,ETV5,FAS,ITPKA,NRXN2,PPARGC1A | NA |
| PIN1 | 1.80e-01 | enzyme | NA | -7.10e-01 | 3.0e-02 | CCND1,CD274,CDKN1A,FASN,PPARD,PPARGC1A,TGFB1,XBP1 | NA |
| BMP10 | 4.60e-01 | growth factor | NA | -7.10e-01 | 1.0e-02 | AASS,CD274,CHRNA2,CMPK2,FGFR2,ID2,ID3,NR4A2,RSAD2,VCAN | 202 (8) |
| ZMPSTE24 | -1.00e-01 | peptidase | NA | -7.20e-01 | 0.0e+00 | ATF3,BTG2,CDKN1A,CISH,DDIT4,Esrra,ETNPPL,GADD45B,GADD45G,IGFALS,IGFBP1,NLRP3,SIRPA,SOCS2 | 475 (23) |
| tacrolimus | NA | chemical drug | NA | -7.20e-01 | 1.0e-02 | BCL2L11,CCND1,CISH,ELL2,ENC1,FKBP5,ID3,IL33,ITPR1,JUN,KLRD1,MAF,NR3C1,ODC1,OSCAR,PDE3B,PIK3R1,Rcan1,RRP12,TRPM6,UNC119 | 441 (19) |
| VDR | -7.00e-02 | transcription regulator | NA | -7.20e-01 | 0.0e+00 | AGT,CCND1,CCND2,CDKN1A,CDT1,CEBPB,CISH,CLDN1,CLDN2,CPT1A,CPT2,FASN,GADD45G,IFI44L,IL1RN,JUN,KSR2,LDLR,NCAPD2,NUPR1,ODC1,PLD1,PNPLA2,PPARGC1B,RB1,REN,RNF144A,SLC34A2,SLCO1B3,TK1,TRPV6 | 440 (24) |
| CD3 group | NA | group | NA | -7.30e-01 | 0.0e+00 | CBLB,CCNE1,FASN,GBP2,NR1I2,ODC1,PLA2G4A,SLC7A5,STAT3,TFRC | 419 (18) |
| PLIN5 | 1.70e+00 | other | NA | -7.30e-01 | 0.0e+00 | ABHD5,FASN,MAFK,NFE2L2,PNPLA2,POR,PPARGC1A,PPARGC1B | 296 (10) |
| INSR | 1.10e-01 | kinase | NA | -7.30e-01 | 0.0e+00 | ACO2,ADIPOR2,ALPL,ARL4A,ARRDC3,ATF3,ATP1B1,CAPN10,CCND1,CCND2,CDKN1A,CERS6,CPT1A,CPT2,CRAT,DIO3,Esrra,FASN,FDFT1,FEM1A,FOXA2,GCK,HHEX,HMGCS1,HNF4A,IDH3A,IGFBP1,INSIG1,INSIG2,KLF9,MKNK1,MSMO1,NFE2L2,PNPLA2,PPARGC1A,PPARGC1B,PSPC1,RHOB,RNF4,SERPINE1,SOCS2,SQLE,TGFB1,TOMM40,TSC22D1 | 499 (21) |
| MAP3K7 | 1.90e-01 | kinase | NA | -7.30e-01 | 3.0e-02 | BIRC3,GBP2,IFI44,IFIT3,IRF1,JUN,OAS2,SERPINE1 | NA |
| CLPP | 4.10e-01 | peptidase | NA | -7.30e-01 | 1.0e-02 | ACO2,ALDOA,CRAT,DCHS1,DLAT,IDH3A,IFIT3,PPARGC1A,RSAD2 | NA |
| TLR7 | -3.00e-02 | transmembrane receptor | NA | -7.30e-01 | 0.0e+00 | AGT,Apol9a/Apol9b,ATF3,CCND1,CD274,CDKN1A,CEBPB,ETV5,IFI44,IFI44L,IFIT3,IL21R,IRF1,KCNH1,MOG,MX1,OAS2,RP1,RSAD2,SLC12A3,SYCP3,TNFAIP3,ZC3H12A | 279 (17) |
| INS | NA | other | NA | -7.40e-01 | 0.0e+00 | ADCYAP1R1,AGT,CBS/LOC102724560,CCND1,CDKN1A,CEBPB,CIDEC,CPT1A,CYP17A1,FAS,FASN,FOXO1,GCK,IGFBP1,IHH,JUN,NFE2L2,NOX4,PPARGC1A,PTPN1,RDH16,TGFB1,XBP1 | 471 (24) |
| luteolin | NA | chemical drug | NA | -7.40e-01 | 4.0e-02 | CCND1,FAS,GCLM,HNF1A,HNF4A,JUN | NA |
| FLCN | -9.00e-02 | other | NA | -7.40e-01 | 0.0e+00 | ADAMTS1,ALDOA,BCL2L11,BHLHE40,EGF,Esrra,GALC,HHEX,PLXND1,PPARGC1A,PPARGC1B,SERPINE1,VPS18,ZC3H12A | 430 (19) |
| bee venom | NA | chemical - endogenous non-mammalian | NA | -7.40e-01 | 0.0e+00 | CREM,CYTIP,IFRD1,IRF1,JUN,NLRP3,NR4A2,NUPR1,RGS1,TNFAIP3,TSC22D1 | 306 (11) |
| TARDBP | NA | transcription regulator | NA | -7.40e-01 | 2.0e-02 | BCL2L11,DHCR24,FDFT1,GBP2,HMGCS1,INSIG1,LDLR,MOG,NUPR1,PCSK9,SQLE | NA |
| SAA | NA | group | NA | -7.50e-01 | 3.0e-02 | ARG1,BCL2L11,IL1RN,IL33,NLRP3 | NA |
| ursodeoxycholic acid | NA | chemical - endogenous mammalian | NA | -7.60e-01 | 3.0e-02 | CYP7A1,FASN,GCLM,MAF,NFE2L2,SLCO1B3,TGFB1 | NA |
| calcium chloride | NA | chemical drug | NA | -7.60e-01 | 0.0e+00 | ANKH,ID3,STC1,TNFRSF11B | NA |
| PARP9 | -8.90e-01 | enzyme | NA | -7.60e-01 | 2.0e-02 | IFI44,IFIT3,IRF1,OAS2 | NA |
| PIK3R1 | 5.90e-01 | kinase | NA | -7.60e-01 | 4.0e-02 | CCND1,CCND2,FOXO1,NFE2L2,PIK3R1,SERPINE1,TGFB1,XBP1 | NA |
| CD28 | -3.20e-01 | transmembrane receptor | NA | -7.70e-01 | 0.0e+00 | BHLHE40,CBLB,CCND1,CCND2,CCNE1,CD274,CISH,CREM,GBP2,GNL2,GPR37,GTF2IRD1,GTPBP4,GYS1,HDAC2,IL15RA,IL21R,IRF1,JUN,MAF,MSLN,NR1I2,ODC1,SLC7A5,SOCS2,STAT3,STOM,SUSD6,TFRC,TNFAIP3,TSC22D1 | 324 (20) |
| SMARCA5 | 1.80e-01 | transcription regulator | NA | -7.80e-01 | 0.0e+00 | ASS1,CCND2,CDKN1A,CHD7,ENC1,FAS,FKBP5,H2-T22,IL17RB,LPAR6,LYN,OSGIN1,PLXND1,RTP4,TCF7L2 | 208 (7) |
| deoxynivalenol | NA | chemical toxicant | NA | -7.80e-01 | 1.0e-02 | CLDN1,CLDN2,CLDN3,CYP17A1,XBP1 | NA |
| MTA1 | -4.90e-01 | transcription regulator | NA | -7.80e-01 | 1.0e-02 | APEX1,CCND1,CCND2,GPRIN3,PIK3R1,SLC16A10,STAT3 | 373 (17) |
| EIF6 | 2.20e-01 | translation regulator | NA | -7.80e-01 | 3.0e-02 | ABHD15,Acnat1/Acnat2,CERS6,DHCR24,FASN,GALNT10,HMGCS1,LDLR,TNFAIP3,TOMM20 | NA |
| TRIB3 | 2.80e-01 | kinase | NA | -7.80e-01 | 0.0e+00 | ASNS,BCL2L11,DDIT4,GDF15,HERPUD1,PSAT1 | 303 (17) |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | NA | chemical toxicant | NA | -7.80e-01 | 1.0e-02 | BACH1,CLDN1,EPHX2,FKBP5,JUN,NLRP3,NR4A2,PAWR,PER2,PYCARD,SLC25A34 | 293 (12) |
| everolimus | NA | chemical drug | NA | -7.90e-01 | 0.0e+00 | CCND1,CCND2,CCNE1,CD274,CDKN1A,CEBPB,FSCN1 | 378 (16) |
| Pkc(s) | NA | group | NA | -7.90e-01 | 0.0e+00 | ATF3,BCL2L11,CDKN1A,CLDN1,CPT1A,DBP,FAS,GADD45B,ID2,IRF6,JUN,MAFK,MAP3K5,NOX4,NR4A2,PER1,PER2,RB1,SERPINE1,STC1,TGFB1,TGM1,XBP1 | 422 (24) |
| SOX2 | 0.00e+00 | transcription regulator | NA | -8.00e-01 | 0.0e+00 | ABTB2,AFAP1L2,ATF3,BHLHE40,CCND1,CD274,CDKN1A,CHST3,CREB3L2,CYP26A1,DLL1,ETV5,FABP7,FBXO15,FOXA2,GADD45B,GCK,ID2,ID3,IER5L,INHBA,IRF6,JAM3,JUN,LIMA1,LIMS2,MFSD2A,MOG,Oasl2,ONECUT1,PIK3R1,PLD1,PPL,PPP2CA,PRKD3,PSAT1,RASGEF1B,SERPINE1,SGK2,SOX6,TGFB1,TGM1,TNFRSF14,VCAN,ZFP57 | 367 (15) |
| BMP6 | 9.00e-02 | growth factor | NA | -8.00e-01 | 1.0e-02 | ADAMTS1,ADGRL2,CDKN1A,ETV5,ID2,ID3,INHBA,MBL2,PCSK6,SERPINE1,XBP1 | 305 (19) |
| CSF1 | -5.50e-01 | cytokine | NA | -8.00e-01 | 0.0e+00 | ARG1,BCL2L11,BHLHE40,CCND1,CCND2,CCNE1,CDKN1A,CXCL11,CYP17A1,DHCR24,DOK2,FAS,FDFT1,GDF15,HMGCS1,ID2,IRF1,JUN,MAFB,MSMO1,MX1,OAS2,OSCAR,PFKFB3,SLC7A5,SOCS2,SQLE,TGFB1,TLR6,TNFAIP3,XBP1 | 377 (23) |
| stearic acid | NA | chemical - endogenous mammalian | NA | -8.10e-01 | 0.0e+00 | ATF3,BCL2L11,FITM2,IGFBP1,PPARGC1A,PPARGC1B,PRKAA1 | 443 (25) |
| isoquercitrin | NA | chemical drug | NA | -8.20e-01 | 0.0e+00 | FASN,FDFT1,INSIG1,LDLR,MSMO1,SQLE | 75 (5) |
| COPS5 | -1.00e-02 | transcription regulator | NA | -8.20e-01 | 0.0e+00 | AMD1,ATF3,CCNE1,CCNF,CCNG1,CDKN1A,DDIT4,GTF2F1,HNRNPD,LMNB1,MKNK2,ODC1,PLK3,RB1,SLC19A2,SLC3A2,SLC7A5,SQLE,STAT3,TBRG4,TFRC,TK1,TMPO,ZFP36L1 | 415 (26) |
| PLK2 | -4.90e-01 | kinase | NA | -8.20e-01 | 0.0e+00 | CMPK2,IL15,IL15RA,IRF1,Mx2,RGS1 | NA |
| PLK4 | -8.00e-02 | kinase | NA | -8.20e-01 | 0.0e+00 | CMPK2,IL15,IL15RA,IRF1,Mx2,RGS1 | NA |
| ALDH2 | -2.00e-02 | enzyme | NA | -8.20e-01 | 0.0e+00 | ADIPOR2,GCLM,PSAT1,SLC1A4,SLC3A2,SLC7A5 | NA |
| NORAD | NA | other | NA | -8.20e-01 | 1.0e-02 | BHLHE40,GADD45B,ID3,JUN,RHOB,SSBP3 | 196 (7) |
| SAHM1 | NA | chemical reagent | NA | -8.20e-01 | 1.0e-02 | BHLHE40,DDIT4,JAM3,P4HA1,PFKFB3,ZBED3 | NA |
| lysophosphatidylinositol | NA | chemical - endogenous mammalian | NA | -8.20e-01 | 2.0e-02 | CD274,CPT1A,IL15,IL33,INSIG1,STC1 | NA |
| ARVib-7 | NA | chemical reagent | NA | -8.20e-01 | 4.0e-02 | CCND1,DHDDS,FKBP5,KPNA2,NRIP1,PATZ1 | NA |
| ARVib-31 | NA | chemical reagent | NA | -8.20e-01 | 4.0e-02 | CCND1,DHDDS,FKBP5,KPNA2,NRIP1,PATZ1 | NA |
| benzene | NA | chemical toxicant | NA | -8.20e-01 | 1.0e-02 | CCNG1,CDKN1A,DHCR24,ID2,PLD1,RHOB,STOM | NA |
| 5-N-ethylcarboxamido adenosine | NA | chemical reagent | NA | -8.20e-01 | 0.0e+00 | ARG1,BCL3,BHLHE40,BTG2,CREM,FOXA1,FOXA2,FZD1,IFIT3,INHBA,NR4A2,ODC1,RGS3,SERPINE1,TAT,TGFB1,UBC,USP2,VCAN | 392 (16) |
| IL12 (family) | NA | group | NA | -8.30e-01 | 2.0e-02 | ATF3,BCL2L11,BCL3,CD274,DDIT4,ETV5,GNA15,IRF1,KLRD1,NFKBIZ,ODC1,SOCS2,TFRC | NA |
| HJURP | -2.10e-01 | other | NA | -8.30e-01 | 0.0e+00 | CCND1,CCNE1,CDKN1A,WEE1 | 350 (13) |
| RNF2 | -3.40e-01 | transcription regulator | NA | -8.30e-01 | 0.0e+00 | CCND2,CDC14A,CDKN1A,FOXA2,GDF15,HNF4A,KLF9,MCC,SYCP3 | NA |
| molybdenum disulfide | NA | chemical reagent | NA | -8.30e-01 | 1.0e-02 | ADAMTS7,CTPS1,DUSP6,EFHD1,IFI44,LIMS2,NREP,PLA2G4A,PPME1,RARRES1,SIRPA,TINAGL1,TNS1 | NA |
| CREBZF | 3.20e-01 | transcription regulator | NA | -8.30e-01 | 0.0e+00 | CEBPB,EDEM1,FASN,HERPUD1,INSIG1,PPARGC1A,XBP1 | 272 (7) |
| cinnamaldehyde | NA | chemical toxicant | NA | -8.40e-01 | 0.0e+00 | AKR1C4,CPT1A,DDIT4,DUSP6,FGFR2,GCLM,IDH3A,INSIG1,NFE2L2,ODC1,PNPLA2,TLR6,UGP2 | 335 (13) |
| miR-29b-3p (and other miRNAs w/seed AGCACCA) | NA | mature microRNA | NA | -8.40e-01 | 0.0e+00 | BCL2L11,CCND1,CEMIP,GPR37,ID2,INSIG1,LAMC1,PIK3R1,SHROOM2,STAT3,TNFAIP3,VCAN,ZFP36L1 | 340 (12) |
| mir-19 | NA | microRNA | NA | -8.50e-01 | 2.0e-02 | BCL2L11,CCND2,CDKN1A,MSMO1,PRKAA1,TNFAIP3 | NA |
| IKBKB | -2.00e-01 | kinase | NA | -8.50e-01 | 0.0e+00 | ATF3,BIRC2,BIRC3,CBLB,CCND1,CDKN1A,CEBPB,CLDN1,DUSP6,FAS,FASN,FOXO1,FSCN1,GBP2,IL1RN,IRF1,LMNB1,MX1,NLRP3,NOCT,PLA2G4A,Rtp3,SOCS2,STAT3,TGFB1,TNFAIP3,TNFRSF11B,VCAN | 429 (18) |
| BMPR1B | NA | kinase | NA | -8.50e-01 | 1.0e-02 | CDKN1A,ID3,SERPINE1,SOX5,SOX6 | 173 (11) |
| TGFBR2 | -5.30e-01 | kinase | NA | -8.50e-01 | 0.0e+00 | ASS1,BCL3,BHLHE40,CCND1,CCNE1,CDKN1A,DDIT4,Esrra,FASN,FKBP5,FOXA1,GADD45B,GADD45G,ID3,IHH,JUN,KCNH1,KCNJ8,Kcnn2,LRIG1,MFSD2A,NFKBIZ,ODC1,Serpinb6b,SERPINE1,SGTB,SH3BP2,SLC7A5,SPATA2,STAT3,TGFB1,TNFAIP8L1,TNFRSF11B,ZC3H12A,ZNF354A | 513 (21) |
| palmitic acid | NA | chemical - endogenous mammalian | NA | -8.50e-01 | 0.0e+00 | ADCYAP1R1,ADIPOR2,ALDOA,ATF3,BCL2L11,BIRC3,CDKN1A,CERS6,CPT1A,EPHX2,ETV5,FASN,FITM2,FOXO1,GCK,GDF15,GPAT3,HNF1A,HNF4A,IGFBP1,IL1RN,IL6R,INHBA,JUN,MAFB,MAP1LC3B,NFE2L2,NR4A2,PNPLA2,PPARD,PPARGC1A,PPARGC1B,PPP2R2B,Ppp2r3d,PRKAA1,PTGER3,PTPN1,RIPK3,SERPINE1,TFRC,TGFB1,WEE1,XBP1 | 510 (23) |
| oblimersen | NA | biologic drug | NA | -8.50e-01 | 0.0e+00 | ATF3,CDKN1A,GADD45B,IFI44,IFIT3,IFRD1,MX1,OAS2,RSAD2 | NA |
| TNF | 2.00e-02 | cytokine | NA | -8.50e-01 | 0.0e+00 | ABTB2,ADAMTS7,AGT,ARG1,ARRDC3,ASS1,ATF3,B4GALNT1,BCL2L11,BCL3,BHLHE40,BIRC2,BIRC3,BTG2,CA12,CCND1,CCND2,CCNE1,CD274,CDKN1A,CEBPB,CERS6,CHSY3,CIDEC,CISH,CLCF1,CLDN1,CNTF,CPT1A,CPT2,CRCP,CREM,CXCL11,CYP17A1,CYP7A1,CYTIP,DBT,DCHS1,DDIT4,DENND4A,DHRS3,DLL4,DUSP6,EDAR,EDNRB,EFNA1,ELAVL1,ETV5,ETV6,EXT1,FAS,FASN,FGFR2,FOXO1,FSCN1,GADD45B,GADD45G,GBP2,GCLM,GDF15,GNA15,HCN3,HIVEP1,HNF4A,ID3,IFIT3,IGFBP1,IL15,IL15RA,IL17RB,IL1RL2,IL1RN,IL21R,IL33,IL6R,INHBA,INSIG1,IRF1,ITPR1,JUN,Kcnn2,LAMA3,LAMC1,LDLR,LGALS9B,LPAR6,LRIG1,LYN,MAP2K6,MAP3K14,MAPK11,MBL2,MEOX2,MFSD2A,MSLN,MX1,NET1,NFE2L2,NFKBIZ,NLRP12,NLRP3,NNMT,NOCT,NOX4,NR1I2,NR3C1,NR4A2,NRIP1,NUP98,OAS2,ODC1,OSCAR,PARP14,PCSK6,PCSK9,PCYT1A,PER2,PEX11A,PIM3,PLA2G4A,PLIN4,PLK3,PPARD,PPARGC1A,PPARGC1B,PPIF,PPP1R3C,PRRG4,PTPN1,PYCARD,RABGEF1,RAC3,RAMP1,RB1,RFX5,RGS1,RGS3,RGS7,RHOB,RIPK3,RND3,RSAD2,Rtp3,S1PR1,S1PR2,SDC4,SEC22B,SERPINB8,SERPINB9,SERPINE1,SGPL1,SIRPA,SLC1A4,SLC7A2,SOCS2,SOS1,SPSB1,SQLE,ST3GAL5,ST3GAL6,STAT3,SYK,TBC1D8,TFRC,TGFB1,TINAGL1,TK1,TLR6,TNFAIP3,TNFRSF11B,TNFRSF14,TP53INP1,USP2,VMP1,VSIR,WWC1,XBP1,ZC3H12A,ZNF750 | 413 (16) |
| MAP3K14 | -6.10e-01 | kinase | NA | -8.60e-01 | 1.0e-02 | BIRC3,FAS,FASN,IL15,PDE3B,PLA2G4A,RIPK3,TNFAIP3,XBP1 | NA |
| MAP2K5 | 7.00e-02 | kinase | NA | -8.70e-01 | 0.0e+00 | AACS,CCND1,CREM,DHCR24,FDFT1,HMGCS1,INSIG1,JUN,LDLR,MSMO1,SQLE | 258 (12) |
| L-serine | NA | chemical - endogenous mammalian | NA | -8.70e-01 | 0.0e+00 | CCND1,CCNE1,CDKN1A,PSAT1 | 372 (17) |
| TO-901317 | NA | chemical reagent | NA | -8.70e-01 | 2.0e-02 | Acot1,ADIPOR2,ASS1,CCND1,CPT1A,CRAT,CYP7A1,FASN,FDFT1,GCK,LDLR,MID1IP1,PCSK9,PFKFB3,POR,PTGER3,RDH16,TGFB1 | NA |
| Esrra | 7.50e-01 | transcription regulator | NA | -8.80e-01 | 0.0e+00 | AGL,AGT,ALDOA,CPT1A,CPT2,CRAT,DLAT,GOT1,GYS1,IDH3A,IHH,PPARGC1A,REN | 255 (7) |
| bisindolylmaleimide I | NA | chemical drug | NA | -8.80e-01 | 0.0e+00 | AGT,ALPL,BIRC3,CCND2,CDKN1A,CLCF1,CLDN1,GDF15,ID3,NR4A2,PITPNB,PLD1,S1PR1,SERPINE1 | 359 (21) |
| miR-291a-3p (and other miRNAs w/seed AAGUGCU) | NA | mature microRNA | NA | -8.80e-01 | 0.0e+00 | CCND1,CCND2,CDK19,CDKN1A,FITM2,HERPUD1,INSIG2,KPNA2,LMNB1,MBNL2,NR4A2,TBC1D2,TNFAIP1 | NA |
| okadaic acid | NA | chemical toxicant | NA | -8.80e-01 | 0.0e+00 | BCL2L11,CCND1,CCND2,CYP17A1,HNF4A,IL1RN,IL21R,JUN,ODC1,RB1,TK1 | 387 (22) |
| IL13 | NA | cytokine | NA | -8.80e-01 | 4.0e-02 | ARG1,ATF3,BCL3,BIRC2,CD101,CEBPB,CISH,CLDN2,CLEC10A,DHCR24,FAS,FOXA2,IL17RB,IL1RN,JUN,LILRB3,MAF,MAP2K6,MSMO1,MTSS1,PLA2G4A,PPARGC1A,SERPINE1,SLC16A6,SLC7A2,ST3GAL6,TFRC,TGFB1,TNFRSF11B,TNS1 | NA |
| DL-fructose | NA | chemical - endogenous mammalian | NA | -8.90e-01 | 2.0e-02 | FASN,NLRP3,NR3C1,TLR6 | NA |
| Tcf7 | -4.40e-01 | transcription regulator | NA | -8.90e-01 | 0.0e+00 | ACSBG1,ARHGEF26,BACH1,CD101,Cd24a,CD79B,CDKN1A,CISH,DHCR24,GPD1L,ID2,ID3,IL15RA,IL21R,ITSN1,LAMA3,LAMC1,LDLR,LRIG1,LYN,LYSMD2,MAF,MSMO1,NRN1,NUPR1,PRKD3,PTPRO,RASGEF1B,RRAGD,Serpinb6b,SGMS1,SOCS2,SPECC1,SQLE,TBC1D2,TGFB1,TSC22D1 | 320 (10) |
| 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole | NA | chemical drug | NA | -9.00e-01 | 0.0e+00 | CREB3L2,GCLM,HERPUD1,NFE2L2,S1PR1,XBP1 | 242 (7) |
| MAVS | -3.00e-02 | other | NA | -9.00e-01 | 1.0e-02 | ALPL,CMPK2,CXCL11,HERPUD1,IFIT3,IL15RA,MAPK11,MX1,OAS2,Oasl2,RSAD2,TLR6,TNFRSF11B | 162 (16) |
| WT1 | 3.00e-02 | transcription regulator | NA | -9.00e-01 | 1.0e-02 | ASNS,BTG2,CBS/LOC102724560,CCND1,CCNE1,CDKN1A,CIRBP,EFNA1,FDFT1,IGFBP1,IL1RN,MSLN,NR4A2,NUP98,ODC1,SERPINE1,SOS1,SQLE,TGFB1,TSC22D1,WNT4 | 424 (26) |
| pifithrin alpha | NA | chemical reagent | NA | -9.00e-01 | 4.0e-02 | CCNG1,CDKN1A,FAS,WNT4 | NA |
| KLF4 | -3.00e-02 | transcription regulator | NA | -9.00e-01 | 0.0e+00 | ABHD5,ADAMTS1,ALPL,ARG1,CCND1,CCND2,CDKN1A,CLDN1,CLEC10A,CYP26A1,DLL1,DLL4,ID3,IL15,INHBA,IRF6,Oasl2,ODC1,PPL,PPP2CA,PREP,RNF6,SERPINE1,TGFB1,TGM1,UGDH,ZC3H12A | 429 (25) |
| ZBTB20 | 1.30e-01 | transcription regulator | NA | -9.00e-01 | 0.0e+00 | CISH,FASN,GCK,GSTM4,IGFALS,IGFBP1,NR3C1,PPARGC1A,SOCS2,TFRC,UGDH | 317 (13) |
| 2,4,5,2’,4’,5’-hexachlorobiphenyl | NA | chemical toxicant | NA | -9.00e-01 | 1.0e-02 | CREM,FASN,GADD45B,GSTM4,HSD17B2,INSIG2,MBNL2,Mx2,SLC1A4,UGDH,WEE1 | NA |
| beta-estradiol | NA | chemical - endogenous mammalian | NA | -9.10e-01 | 0.0e+00 | ABHD5,ACER2,Acot1,ADAMTS1,ADCY9,ADGRG2,ADRA1B,AGT,ALDOA,ANKH,APEX1,ARG1,ARL4A,ASS1,ATF3,ATP1B1,ATP2B2,AURKA,BCL2L11,BHLHE40,BIRC3,BTG2,C5AR2,CA12,CACNB4,CBS/LOC102724560,CCDC146,CCND1,CCND2,CCNE1,CCNG1,CD274,CDKN1A,CDT1,CEBPB,CISH,CITED4,CLDN1,CLDN2,CLDN3,CPT1A,CREB3L2,CREM,CSF3R,CTPS1,CXCL11,CYP17A1,DBP,DDB2,DDIT4,DFFB,DHCR24,DLL1,DLL4,DOT1L,DUOX2,DUSP6,DYNLL1,EFNA1,EGF,ELAVL1,ENC1,Esrra,ETV5,ETV6,FAS,FASN,Fbxl19,FDFT1,FGFR2,FOXA1,FOXO1,FSCN1,GADD45B,GADD45G,GART,GBP2,GDF15,GNE,GNL3,GPRIN3,GTF2IRD1,HDAC2,HERPUD1,HIGD1A,HIVEP1,HMGCS1,HNRNPD,HSD17B2,HSPH1,ID2,ID3,ID4,Ifgga2l1/RGD1309362,IFRD1,IGFBP1,IL15,IL17RB,IL6R,INHBA,INSIG1,INSIG2,IRF1,IRF6,ITGA9,ITPKA,JUN,KLF9,KPNA2,LAMA3,LDLR,LIMA1,LIN7A,LPIN1,LRIG1,LRRC8A,MAF,MAP2K6,MCM10,MEIS2,MICAL2,Mllt3,MOSPD1,MSMO1,MX1,Mx2,MYO1B,NECTIN1,NET1,NFE2L2,NFYA,NOP56,NPC1,NR2C1,NR3C1,NR4A2,NRIP1,NRP2,NUPR1,Oasl2,ODC1,ORC1,P4HA1,PAQR3,PDE3B,PEX11A,PIK3R1,PLA2G4A,PLEKHA4,POLA1,PPARGC1A,PPARGC1B,PPL,PPM1K,PPP1R3C,PPP1R9B,PPP2CA,PPP2R2B,PREP,PSAT1,PTGER3,PTP4A1,PTPN1,PTTG1IP,PXMP4,RB1,Rcan1,REEP1,REN,RFX5,RGS1,RGS3,RGS7,RND3,RNF4,RPRM,RTP4,S1PR1,SBK1,SCML4,SDC4,SELENBP1,SERPINE1,SFXN5,SGSM2,SLC12A3,SLC19A2,SLC25A15,SLC25A25,SLC34A2,SLC38A2,SLC3A2,SLC7A2,SLC7A5,SMTNL2,SOCS2,SOS1,SOX5,SQLE,Srrm1,STARD7,STAT3,STBD1,STC1,SYK,SYNE1,TGFB1,THRB,TK1,TMEM120B,TMEM150C,TMPO,TNFAIP3,TNFRSF11B,TNK2,TNS1,TP53INP1,TSC22D1,UNC5C,VCAN,WEE1,WNT4,WWC1,XBP1,ZFP36L1 | 523 (20) |
| ZBTB16 | 5.70e-01 | transcription regulator | NA | -9.10e-01 | 0.0e+00 | ACER2,ASL,B4GALNT1,BACH2,CCND1,CD180,CD200R1L,Cd24a,CD274,CDKN1A,CYP7A1,DHRS3,EARS2,FABP7,FOXO1,GALE,GOT1,HSD17B2,ID2,ID3,IL17RB,IL21R,IRF6,KCNJ8,LMO4,MAF,NFKBIZ,ODC1,PIK3R1,Pla2g12a,POLG2,SDS,SGMS1,TCF7L2,TLR6,TNFAIP8L1,TSC22D1,UGP2,UPP2 | 359 (11) |
| miR-221-3p (and other miRNAs w/seed GCUACAU) | NA | mature microRNA | NA | -9.10e-01 | 2.0e-02 | BCL2L11,DDIT4,MAF,PIK3R1,SH3BP2 | NA |
| phenylephrine | NA | chemical drug | NA | -9.20e-01 | 3.0e-02 | EDNRA,EDNRB,Esrra,JUN,MTSS1,NFE2L2,RAPH1,REN,THRB | NA |
| MMP2 | -6.00e-02 | peptidase | NA | -9.30e-01 | 0.0e+00 | ACO2,CCND1,CDKN1A,CEBPB,CITED4,IL1RN,INSIG1,INSIG2,LDLR,PPARGC1A,TGFB1 | 452 (20) |
| Betacatenin/TCF | NA | complex | NA | -9.30e-01 | 0.0e+00 | ALPL,CCND1,JUN,TNFRSF11B | NA |
| SKP2 | -2.90e-01 | other | NA | -9.30e-01 | 1.0e-02 | CCND1,CCND2,CCNE1,CDKN1A,ODC1,PAX8 | 364 (19) |
| tetrachlorodibenzodioxin | NA | chemical toxicant | NA | -9.30e-01 | 0.0e+00 | ABHD5,ACER2,ADIPOR2,ASNS,ATOH8,BACH2,C11orf24,CARD10,CCND1,CCNE1,CD274,CDKN1A,CEBPB,CHD7,CYP17A1,DACT2,DUSP6,EGF,ENC1,FAS,FMO3,GADD45B,GDF15,Hsd3b4 (includes others),ID3,IGFBP1,INSIG2,IRF1,JUN,LRP2,LYST,MAFB,MBL2,NAT2,NFE2L2,NFYB,NR3C1,NRG4,ODC1,PLXNA2,RDH16,S1PR1,SERPINA7,SERPINE1,SLC16A10,SLC17A2,SLC7A5,Smlr1,SOCS2,TDO2,TGM1,TK1,TNFAIP8L1,UGDH,ZFP57 | 432 (22) |
| dimethyl itaconate | NA | chemical reagent | NA | -9.30e-01 | 0.0e+00 | ATF3,GCLM,IFIT3,IRF1,NFE2L2,NFKBIZ,RSAD2,XBP1 | NA |
| CD3 | NA | complex | NA | -9.40e-01 | 1.0e-02 | BCL2L11,BIRC3,CCND1,CCND2,CCNE1,CD274,CISH,CREM,FAS,FMO3,GNL2,GPR37,GTF2IRD1,GTPBP4,GYS1,HDAC2,ID3,ID4,IL15RA,IL21R,IRF1,ITPR1,JUN,LYN,MAF,MSLN,NFE2L2,ODC1,PREP,PTP4A1,RB1,RBM3,SOCS2,SOS1,STOM,SUSD6,TFRC,TGFB1,TMPO,TNFAIP3,WEE1,ZFP36L1 | 403 (18) |
| MAPK7 | -3.40e-01 | kinase | NA | -9.40e-01 | 0.0e+00 | AACS,ADAMTS1,CCND1,DHCR24,FASN,HMGCS1,INSIG1,JUN,LDLR,MSMO1,SQLE | 358 (20) |
| CPT1B | 4.90e-01 | enzyme | NA | -9.40e-01 | 0.0e+00 | CBLB,COX10,FASN,FOXO1,GCK,GLYAT,INSIG1,MKNK1,MKNK2,PDE3B,PFKFB3,PIK3R1,PPARGC1A,PPP1R3C,PRKAA1,PRKAG2,PTPN1,SOCS2,SOS1,SYCP3 | 138 (7) |
| NR0B2 | -4.00e-01 | ligand-dependent nuclear receptor | NA | -9.50e-01 | 0.0e+00 | AGT,ARG1,BAAT,CDKN1A,CIDEC,CPT1A,CYP7A1,FASN,GCK,HNF1A,HNF4A,IL1RN,IL33,LPIN1,PPARGC1A,SERPINE1,TGFB1,TNFAIP3 | 318 (21) |
| sulindac sulfide | NA | chemical drug | NA | -9.50e-01 | 0.0e+00 | ATF3,CCND1,CDKN1A,CEBPB,DYNLL1,ETNPPL,GADD45G,GDF15,IFRD1,INSIG1,MSMO1,PIK3R1,PPARD,STAT3,STC1 | 452 (22) |
| HMGA1 | -2.00e-02 | transcription regulator | NA | -9.60e-01 | 0.0e+00 | AGT,ALPL,ARL4A,CCND1,CCND2,CYP7A1,DRAM2,GNA15,ID3,IGFALS,IGFBP1,IL15,INSIG1,NECTIN1,RHOB,SDC4,SEC24D,STAT3,SYK,ZFP57 | 398 (20) |
| EIF4EBP1 | 7.00e-02 | translation regulator | NA | -9.60e-01 | 1.0e-02 | ARG1,CCND1,CEBPB,CLPX,IL1RN,MAF,PNPLA2,PPARGC1A | 401 (17) |
| RHOA | -1.00e-01 | enzyme | NA | -9.70e-01 | 0.0e+00 | AGT,CCND1,CCNE1,CDKN1A,CEBPB,CXCL11,FAS,GDF15,IRF1,JUN,RHOB,RND3,STAT3,TGFB1 | 335 (22) |
| SPI1 | -3.90e-01 | transcription regulator | NA | -9.70e-01 | 0.0e+00 | CCND1,CCND2,CD180,CD79B,CDKN1A,CMPK2,CSF3R,DUSP6,FOXO1,HELZ2,ID2,ID3,IFI44,IFI44L,IFIT3,IL1RN,IL33,JUN,LILRB3,MX1,OSCAR,P2RY10,RSAD2,TK1,TNFRSF14 | 420 (20) |
| N-cor | NA | group | NA | -9.80e-01 | 0.0e+00 | ADIPOR2,ALDOA,CCND1,CDKN1A,CIDEC,DHRS3,FASN,FZD1,RHOB,RNF144B,TBC1D2,ZNF703 | 462 (24) |
| PDGF-AA | NA | complex | NA | -9.80e-01 | 3.0e-02 | CDKN1A,ID4,LDLR,TGFB1 | NA |
| HGF | -2.40e-01 | growth factor | NA | -9.80e-01 | 0.0e+00 | ACKR4,ADAMTS1,ADGRL2,ARRDC3,ASNS,ATF3,AURKA,BIRC2,BIRC3,CCND1,CCNF,CCNG1,CDC14A,CDKN1A,CLCF1,CYP17A1,DUSP6,DYNLL1,EPHA4,FKBP5,FNDC3A,FOXA1,FOXA2,IL15RA,INHBA,INSIG1,ITPR1,JUN,LDLR,MEOX2,MPHOSPH10,NFKBIZ,NOLC1,NPC1,NR4A2,NRCAM,NRIP1,PLXNA2,PPARD,PRKAA1,RHOB,SERPINE1,SLC19A2,SOCS2,STC1,TBC1D8,TGFB1,TNFAIP3 | 464 (20) |
| spironolactone | NA | chemical drug | NA | -9.80e-01 | 2.0e-02 | CDKN1A,CEBPB,EDNRB,FASN,FKBP5,NR3C1,PER1,REN,TGFB1,USP2 | NA |
| RAC1 | -1.30e-01 | enzyme | NA | -9.90e-01 | 0.0e+00 | AGT,ATF3,CCND1,DLL4,FAS,FOXO1,IL33,IL6R,JUN,RAC3,SOX5,SOX6,STAT3,TGFB1 | 418 (21) |
| lenalidomide | NA | chemical drug | NA | -9.90e-01 | 1.0e-02 | CCND1,CEBPB,GNPNAT1,IFIT3,IGSF11,ITPR1,LIMA1,MRS2,NFKBIZ,PPIF,RAD18,RGS1,ROR1,RTP4,SLC7A2,SPRYD7,SPSB1,STAMBPL1,TCF7L2,WNT4,XBP1 | 362 (12) |
| alvocidib | NA | chemical drug | NA | -1.00e+00 | 2.0e-02 | BIRC3,CCND1,CCNE1,CDKN1A,RB1 | NA |
| MET | -3.20e-01 | kinase | NA | -1.00e+00 | 0.0e+00 | AURKA,CCND1,CCND2,CD274,CDKN1A,CLDN1,IL15,IL15RA,INHBA,JUN,LAMA3,NFKBIZ,NOX4,NREP,PIM3,PPARGC1A,PTPN1,TGFB1,TSC22D1 | 439 (25) |
| thenoyltrifluoroacetone | NA | chemical reagent | NA | -1.00e+00 | 0.0e+00 | AGT,BIRC3,SERPINE1,TGFB1 | 338 (19) |
| GPAT4 | 4.40e-01 | enzyme | NA | -1.00e+00 | 0.0e+00 | ATF3,GPAT3,NFE2L2,XBP1 | NA |
| NELFB | -2.50e-01 | other | NA | -1.00e+00 | 0.0e+00 | ATF3,CDKN1A,GADD45B,MKNK2 | 273 (7) |
| PPP3R1 | 2.20e-01 | phosphatase | NA | -1.00e+00 | 0.0e+00 | BCL3,CACNB2,CCND2,Fam169b,LRP2,SHROOM2,SLC34A2,SLC7A10,USP2 | NA |
| phytohemagglutinin | NA | chemical drug | NA | -1.00e+00 | 0.0e+00 | AGT,BCL3,CACNB2,CCND2,FAS,FGR,GYS1,HDAC2,HIVEP1,IDH3A,IL15RA,IL21R,MEIS2,NFYB,NOP56,NRIP1,PLD1,POLR3A,PTGER3,PTPN1,RB1,STAT3,TMPO,VGLL4,XBP1 | 375 (13) |
| PXDN | -3.60e-01 | enzyme | NA | -1.00e+00 | 1.0e-02 | CDKN1A,DDIT4,IGFBP1,JUN | NA |
| IHH | -7.50e-01 | enzyme | NA | -1.00e+00 | 1.0e-02 | ALPL,CA1,CCND1,FGFR2,FZD1,PLIN4,PLIN5,Serpinb6b,TCF7L2,TNFRSF11B | NA |
| BMPR2 | -5.00e-02 | kinase | NA | -1.00e+00 | 1.0e-02 | CD274,EPHA4,ID2,INHBA,TNFRSF11B | NA |
| MGLL | 2.20e-01 | enzyme | NA | -1.00e+00 | 1.0e-02 | CPT1A,FASN,PNPLA2,PPARGC1A | NA |
| JAK3 | -3.10e-01 | kinase | NA | -1.00e+00 | 2.0e-02 | CCNE1,CD274,GADD45G,IRF1,MAF,STAT3 | NA |
| STAT1/3/5 dimer | NA | complex | NA | -1.00e+00 | 2.0e-02 | BCL3,CISH,IRF1,SOCS2 | NA |
| SIRT2 | -1.00e-01 | transcription regulator | NA | -1.00e+00 | 3.0e-02 | AACS,FDFT1,Oasl2,SQLE | NA |
| IOX2 | NA | chemical reagent | NA | -1.00e+00 | 3.0e-02 | INSIG2,JUN,P4HA1,PPP1R3G | NA |
| VH032 | NA | chemical reagent | NA | -1.00e+00 | 3.0e-02 | INSIG2,JUN,P4HA1,PPP1R3G | NA |
| buthionine sulfoximine | NA | chemical drug | NA | -1.00e+00 | 4.0e-02 | CD274,NFE2L2,SERPINE1,TNFAIP3 | NA |
| IL18 | 2.70e-01 | cytokine | NA | -1.00e+00 | 4.0e-02 | ARG1,ATF3,CXCL11,DDIT4,EDNRB,FAS,GADD45B,GADD45G,GNA15,IRF1,JUN,NFKBIZ,SLC3A2,SOCS2,TNFRSF11B | NA |
| RAS | NA | group | NA | -1.01e+00 | 0.0e+00 | AURKA,BCL2L11,CCND1,CD274,CDKN1A,CSF3R,GBP2,Ifi47,IRF1,JUN,LDLR,ODC1,PLD1,PPARD,SERPINE1 | 406 (23) |
| TNFSF13 | 1.90e-01 | cytokine | NA | -1.01e+00 | 3.0e-02 | BCL2L11,CCND2,MAF,RB1,XBP1 | NA |
| GPER1 | -2.00e-02 | G-protein coupled receptor | NA | -1.02e+00 | 0.0e+00 | ATF3,BHLHE40,CCND1,CDKN1A,DDIT4,FASN,JUN,NR4A2,TNFAIP3 | 529 (25) |
| RIGI | NA | enzyme | NA | -1.02e+00 | 1.0e-02 | ALPL,CXCL11,DLL1,IFI44,IFIT3,IL15RA,IRF1,MAPK11,MX1,RSAD2,TLR6,TNFAIP3,TNFRSF11B,WNT4 | 185 (15) |
| miR-3648 (miRNAs w/seed GCCGCGG) | NA | mature microRNA | NA | -1.03e+00 | 0.0e+00 | CCND1,CITED4,DOT1L,EVA1C,ITPKA,JUN,KLHL25,MAP1LC3B,SECTM1,SMARCD2,TBC1D14,ZBED3 | NA |
| PRMT5 | 1.00e-01 | enzyme | NA | -1.03e+00 | 0.0e+00 | CCND1,CCNE1,CD274,CYP7A1,FASN,PER1,PPARGC1A,PTPRO,SLC45A3,TNFAIP3 | 455 (27) |
| CYP19A1 | 4.00e-02 | enzyme | NA | -1.03e+00 | 0.0e+00 | ASPG,CCND1,CCNE1,CLCF1,CYP17A1,CYP7A1,EGF,FASN,FKBP5,GBP2,JUN,PPP1R9B,RB1,TDO2,TGFB1,TGM1 | 425 (24) |
| LUCAT1 | NA | other | NA | -1.03e+00 | 0.0e+00 | CDKN1A,HNF1A,IGFBP1,IL15,NR4A2,SLCO1B3 | NA |
| NR1H3 | -5.10e-01 | ligand-dependent nuclear receptor | NA | -1.04e+00 | 0.0e+00 | ATF3,AURKA,CD274,CDKN1A,CHEK2,CYP7A1,CYTH1,CYTIP,FASN,FDFT1,GCK,IL1RN,INSIG2,LDLR,MID1IP1,PFKFB1,PPARGC1A,RB1,REN,SLC16A10,THRB,UBC,VCAN | 448 (23) |
| BHLHE40 | -1.07e+00 | transcription regulator | NA | -1.04e+00 | 0.0e+00 | ATF3,ATP1B1,Cd24a,CD274,EXT1,FAS,FASN,GBP2,IL6R,INHBA,LDLR,LYN,NLRP3,P4HA1,PARP9,PER1,PFKFB3,PLA2G4A,RGS1,RND3,SDC4,SH3PXD2A,SLC7A2,ST3GAL5,STAT3,TLR6,TPST2,ZNFX1 | 338 (11) |
| PRKCB | -6.00e-02 | kinase | NA | -1.04e+00 | 0.0e+00 | CCND1,CDKN1A,CYP7A1,FASN,FOXO1,GCK,JUN,PFKFB3,PPARGC1A,PPP1R3C,SERPINE1,TGFB1 | 440 (23) |
| tetradecanoylphorbol acetate | NA | chemical drug | NA | -1.04e+00 | 0.0e+00 | ADAMTS1,AGT,ARG1,ATF3,ATP23,AURKA,BCL3,BIRC3,BTG2,CBS/LOC102724560,CCND1,CCND2,CCNE1,CDKN1A,CEMIP,CIDEC,CLCF1,CLDN1,CREM,CSF3R,CYP17A1,CYP7A1,DBP,DDIT4,DIO3,DUSP6,EGF,EPHA4,ETNPPL,FAHD1,FAS,FKBP5,FZD1,GADD45B,GDF15,HNF1A,HNF4A,HSD17B2,ID2,ID3,IGFBP1,IL1RN,IL6R,INHBA,INO80B,IRF1,JUN,LDLR,LIN7A,LYST,MAF,MARS2,MEIS2,MKNK1,MTFMT,NLRP3,NOCT,NR1I2,NR4A2,ODC1,PALMD,PDE3B,PER1,PER2,PLD1,PPARD,PTPN1,PTPRO,RAD17,RECQL4,REN,RGS1,RNF4,S1PR1,SDC4,SERPINB9,SERPINE1,SETBP1,STAT3,STC1,TAT,TGFB1,TGM1,TK1,TLR6,TMEM150C,TNFAIP3,TNFRSF11B,TRIM45,VCAN | 436 (20) |
| AHR | -1.80e-01 | ligand-dependent nuclear receptor | NA | -1.05e+00 | 0.0e+00 | ADIPOR2,ALDOA,ATOH8,ATP1B1,BTG2,CCND1,CCNE1,CCNF,CD274,CDKN1A,CERS3,CERS6,CGREF1,CHD7,CXCL11,CYP17A1,DACT2,DUOX2,DUSP6,EPHX2,FAS,FASN,FGFR2,FMO3,GDF15,GOT1,Hsd3b4 (includes others),HSPH1,IGFBP1,IL15,IL21R,INSIG2,IRF1,JUN,LAMA3,LYST,NFE2L2,NFYB,NLRP3,NNMT,NRG4,PLXNA2,POLA1,RDH16,SERPINA7,SERPINE1,SLC16A10,SLC17A2,SLC1A4,Smlr1,STAT3,TDO2,TGFB1,TK1,TNFAIP8L1,TNFRSF14 | 419 (20) |
| SMAD4 | 3.00e-02 | transcription regulator | NA | -1.05e+00 | 3.0e-02 | ALPL,AURKA,CCND1,CCND2,CCNE1,CDKN1A,CYP17A1,ETV6,FSCN1,GADD45B,HHEX,HNF4A,ID2,IHH,INHBA,KLF15,NFE2L2,POR,SERPINE1,TGFB1,UNC119 | NA |
| LGALS1 | 8.00e-02 | other | NA | -1.05e+00 | 2.0e-02 | CCND2,CDKN1A,GPAT3,INSIG1,MAF,SERPINE1,TFRC,TGFB1,TNFAIP3 | NA |
| USF2 | 2.10e-01 | transcription regulator | NA | -1.06e+00 | 0.0e+00 | AGT,CPT1A,FASN,GCK,IGFBP1,P4HA1,REN,SERPINE1,TGFB1 | NA |
| CAMKK2 | -4.00e-02 | kinase | NA | -1.07e+00 | 0.0e+00 | CCND1,CDKN1A,FASN,PPARGC1A | 427 (23) |
| PURPL | NA | other | NA | -1.07e+00 | 1.0e-02 | EFNA5,MAP1LC3B,OAS2,TMPO | NA |
| hemoglobin | NA | complex | NA | -1.07e+00 | 1.0e-02 | CDKN1A,GCLM,REN,TFRC | 148 (7) |
| PS-1145 | NA | chemical drug | NA | -1.07e+00 | 1.0e-02 | BIRC2,IRF1,RB1,TNFAIP3 | 303 (11) |
| FXR ligand-FXR-Retinoic acid-RXRα | NA | complex | NA | -1.07e+00 | 2.0e-02 | BAAT,FASN,NR1I2,SLCO1B3 | NA |
| FUT8 | -1.70e-01 | enzyme | NA | -1.07e+00 | 2.0e-02 | CD274,NFE2L2,SQLE,TFRC | NA |
| SENP1 | 2.80e-01 | peptidase | NA | -1.07e+00 | 4.0e-02 | ARG1,IDH3A,LDLR,XBP1 | NA |
| FOXC1 | -4.90e-01 | transcription regulator | NA | -1.07e+00 | 0.0e+00 | ALPL,BCL2L11,DLL1,FOXA1,FOXO1,IFIT3,IHH,IRF1,IRF6,MX1,OAS2,SERPINE1,SOX6,TGM1,TSC22D1,ZNF750 | NA |
| DACH1 | -5.00e-02 | transcription regulator | NA | -1.07e+00 | 4.0e-02 | CDKN1A,JUN,SERPINE1,TGFB1,TNFAIP3 | NA |
| DIO3 | 1.07e+00 | enzyme | NA | -1.07e+00 | 3.0e-02 | ADCYAP1R1,B4GALNT1,CIRBP,FGF11,GCK,INHBA,KCNH1,KLF9,LZTS1,MEOX2,SLC13A2,SLC16A4,STC1,SYCP3 | NA |
| anisomycin | NA | chemical - endogenous non-mammalian | NA | -1.08e+00 | 0.0e+00 | ATF3,CCND1,CDKN1A,IRF1,JUN,LDLR,PPP2CA,RGS7,SERPINE1,TCF7L2 | 455 (23) |
| RBP4 | 3.00e-02 | other | NA | -1.09e+00 | 2.0e-02 | ARG1,NLRP3,PYCARD,TGFB1 | NA |
| WR 1065 | NA | chemical drug | NA | -1.09e+00 | 1.0e-02 | CDKN1A,DDB2,FAS,GDF15,ZFP36L1 | 384 (20) |
| Tnf (family) | NA | group | NA | -1.10e+00 | 0.0e+00 | ATF3,BIRC2,BIRC3,CCND1,CD274,CIRBP,CLDN2,CXCL11,IL1RL2,IL1RN,IL33,INHBA,JUN,NOX4,PTGER3,SERPINB8,SERPINB9,SERPINE1,TNFAIP3,TNFRSF14 | 375 (19) |
| siponimod | NA | chemical drug | NA | -1.10e+00 | 3.0e-02 | ACER2,BACH2,BCL2L11,CIART,FAM78A | NA |
| RORC | NA | ligand-dependent nuclear receptor | NA | -1.11e+00 | 0.0e+00 | ALDOA,Aox3,ASNS,ATP1B1,B3GALT1,BHMT,CISH,DHCR24,FDFT1,GADD45B,GOT1,GSTM4,Hsd3b4 (includes others),IDH3A,IGFBP1,NAT2,NLRP3,NNMT,NOCT,POR,PPP1R3C,RDH16,SELENBP1,SLC13A2,SLC16A10,SLC7A2,SLC7A5,SULT1C3 | NA |
| HEIH | NA | other | NA | -1.11e+00 | 4.0e-02 | CACNB2,FAS,GADD45B,JUN | NA |
| CSF2 | -2.00e-02 | cytokine | NA | -1.12e+00 | 0.0e+00 | ARG1,AURKA,BCL2L11,BCL3,BIRC3,CCND1,CCND2,CCNF,CD101,CD180,CDKN1A,CISH,CLCF1,DOK2,DUSP6,FAS,FBXO31,GCLM,GDF15,HSPH1,ID2,ID3,IFRD1,IL15,IL1RN,INHBA,JUN,MFSD2A,MKNK1,NCAPD2,NET1,NLRP3,NR4A2,ODC1,PIM3,PLD1,PPIF,PRKAA1,RB1,RBM3,RECQL4,SERPINB9,SOCS2,TGFB1,TNFAIP3,XBP1 | 468 (18) |
| EIF2AK2 | -1.90e-01 | kinase | NA | -1.12e+00 | 0.0e+00 | ARG1,ATF3,BHLHE40,BIRC2,CCND1,CDKN1A,CEBPB,FAS,IRF1,JUN,NNMT,PARP9,TNFAIP3 | 314 (16) |
| SN-38 | NA | biologic drug | NA | -1.13e+00 | 1.0e-02 | BIRC2,BIRC3,CDKN1A,CHEK2,FAS,GDF15 | 379 (18) |
| BMP15 | -1.20e-01 | growth factor | NA | -1.13e+00 | 2.0e-02 | Hsd3b4 (includes others),ID2,ID3,PCSK6 | NA |
| NLRX1 | -1.30e-01 | other | NA | -1.13e+00 | 1.0e-02 | AGT,BIRC3,CARD10,IRF1,MAP3K14,PIK3R1,TNFAIP3 | 313 (17) |
| BNIP3L | 1.70e-01 | other | NA | -1.13e+00 | 2.0e-02 | AURKA,CD79B,PFKFB3,STAT3,SYK,TFRC,TGFB1 | NA |
| ATP | NA | chemical - endogenous mammalian | NA | -1.14e+00 | 1.0e-02 | ARG1,BCL2L11,CCND1,CLDN1,FOXO1,GCLM,IL1RN,IL33,NLRP3,PYCARD,REN,SERPINE1,SLC12A3 | 439 (20) |
| TCR | NA | complex | NA | -1.15e+00 | 0.0e+00 | ALDOA,BACH2,BCL2L11,BCL3,BIRC3,CBLB,CCND1,CCNE1,CISH,CXCL11,CYTIP,ELL2,ETV5,FAS,GADD45B,GADD45G,ID3,IFI44,IFI44L,IFIT3,IRF1,JUN,LMNB1,MAF,MX1,NR3C1,ODC1,PDE3B,PIK3R1,RSAD2,SOCS2,STAT3,TGFB1,TNFAIP3,TSC22D1,ZNFX1 | 387 (20) |
| CD36 | 6.00e-02 | transmembrane receptor | NA | -1.15e+00 | 0.0e+00 | ARG1,FAS,FASN,IL15,NLRP3,PNPLA2,PPARGC1A,PTPN1,SERPINE1,SYK,TNFRSF11B,XBP1 | 455 (23) |
| 17-alpha-ethinylestradiol | NA | chemical drug | NA | -1.16e+00 | 0.0e+00 | ARRDC3,ASNS,BCL3,CDKN1A,CYP17A1,CYP7A1,FABP7,GDF15,JUN,LDLR,LPIN1,ODC1,PLK3,SLC34A2,SLCO1B3,UGP2,WNT4 | 566 (23) |
| ORMDL3 | 1.10e-01 | other | NA | -1.17e+00 | 2.0e-02 | CXCL11,MAP1LC3B,OAS2,TGFB1 | NA |
| CGAS | NA | enzyme | NA | -1.17e+00 | 0.0e+00 | ARG1,CD274,CDKN1A,IFI44,IFI44L,IFIT3,MAP1LC3B,Mx2,RSAD2 | 276 (18) |
| FSH | NA | complex | NA | -1.17e+00 | 0.0e+00 | ADAMTS1,ADCY9,ALPL,BTG2,CARD10,CCND1,CCND2,CREM,CYP17A1,DHRS3,EFNA1,ELL2,ENC1,FKBP5,FOXO1,GOT1,ID4,IL1RN,IL6R,INHBA,ITPR1,JUN,LDLR,MAP1LC3B,MAP3K5,MAPK6,MSMO1,PAWR,PCSK6,PTP4A1,PTPN1,RAD17,RGS7,RHOB,RPRM,SERPINE1,TFRC,TK1,TNFAIP3,TNFRSF11B | 473 (23) |
| GRP | NA | growth factor | NA | -1.19e+00 | 4.0e-02 | CCND1,CCNE1,IL33,JUN | NA |
| TAFAZZIN | NA | enzyme | NA | -1.19e+00 | 0.0e+00 | ADAMTS1,ADGB,ARG1,ARHGAP29,BCL2L11,CCND1,CCNE1,CD180,CD79B,CEP85,CYTIP,GSTT2/GSTT2B,Irgm1,LDLR,LRP2,P4HA1,PDE3B,PIK3R1,S1PR1,SERPINE1,TBC1D2,TELO2,TFRC,TGFB1,UGDH | 361 (21) |
| IRS1 | -5.00e-01 | enzyme | NA | -1.19e+00 | 4.0e-02 | CCND1,CEBPB,Esrra,FASN,GCK,ID2,IGFBP1,LDLR,PIK3R1,PPARGC1A,PPARGC1B | NA |
| SNCA | 0.00e+00 | enzyme | NA | -1.19e+00 | 0.0e+00 | AGT,ARG1,BAIAP2,BHLHE40,CA12,CHRNA2,COBL,COLGALT2,DHRS3,EFNA1,EGF,FABP7,GBP2,Ifgga2l1/RGD1309362,Ifi47,IFRD1,IRF1,ITPKA,KLF11,MAP1LC3B,MX1,Mx2,NLRP3,NR4A2,NRP2,PDZRN3,PLK3,RSAD2,SERPINE1,SGMS1,SLC17A9,TRIM47,WEE1 | 395 (20) |
| PARP1 | 3.00e-02 | enzyme | NA | -1.21e+00 | 0.0e+00 | CCND1,CD274,CDKN1A,FAS,FASN,GBP2,GDF15,Igtp,ITPR1,JUN,POLA1,RB1,SH3BP2,SLC38A2,SOCS2 | 448 (23) |
| STAT | NA | group | NA | -1.21e+00 | 3.0e-02 | AGT,CDKN1A,CISH,IRF1,SOCS2 | NA |
| NFIL3 | 6.00e-02 | transcription regulator | NA | -1.22e+00 | 0.0e+00 | CDKN1A,CPT1A,FAS,FASN,GADD45B,ID2,PLIN4 | 421 (23) |
| MAP3K5 | 1.38e+00 | kinase | NA | -1.22e+00 | 0.0e+00 | BCL2L11,CCND1,CDKN1A,JUN,MAP3K5,TGFB1,TGM1 | 413 (21) |
| magnesium | NA | chemical - endogenous mammalian | NA | -1.22e+00 | 0.0e+00 | CDKN1A,HIF3A,MRS2,PTP4A1,Slc41a3,TNFRSF11B | 328 (20) |
| NR1I2 | 1.16e+00 | ligand-dependent nuclear receptor | NA | -1.23e+00 | 0.0e+00 | BHMT,CDKN1A,CPT1A,CYP7A1,FASN,GOT1,HMGCS1,HNF4A,Hsd3b4 (includes others),IL33,INSIG1,INSIG2,JUN,NR1I2,POR,SLCO1B3,STAT3,TNFRSF11B,TNFRSF14 | 465 (26) |
| NFATC1 | 1.60e-01 | transcription regulator | NA | -1.23e+00 | 2.0e-02 | ATF3,CCND1,CCND2,FAS,GCK,HNF1A,HNF4A,IL33,NOX4,OSCAR,XBP1 | NA |
| MAP3K1 | NA | kinase | NA | -1.24e+00 | 0.0e+00 | ATF3,BIRC2,BIRC3,CCND1,CYP7A1,FAS,JUN,LDLR,PLA2G4A,PPARD,RGS7,SERPINE1,TGFB1 | 445 (21) |
| MAP2K2 | 4.00e-02 | kinase | NA | -1.25e+00 | 4.0e-02 | ACSBG1,CDKN1A,ETV5,PLD1 | NA |
| PDGFB | -1.90e-01 | growth factor | NA | -1.25e+00 | 3.0e-02 | ADAMTS7,CCND1,FOXO1,IL1RN,RIPK3,S1PR2,STAT3 | NA |
| SMARCA4 | -8.00e-02 | transcription regulator | NA | -1.26e+00 | 0.0e+00 | AGT,ASNS,CCND1,CCND2,CDKN1A,CEBPB,CHEK2,CLCF1,CLDN1,CLPX,CYP26A1,DLL1,DUSP6,EDNRA,EPHA4,FAS,FGFR2,FKBP5,FOXA2,GADD45B,GADD45G,GYS1,HNF4A,ID3,IL15RA,INHBA,IRF1,IRF6,ITPR1,JUN,LAMA3,NECTIN1,NFKBIZ,NRP2,PCSK9,PPCS,PTP4A1,RAMP1,RGS1,SERPINB8,SERPINE1,SOCS2,STAMBPL1,STK33,STXBP6,SYK,TCF7L2,TGFB1,TNFRSF14,TRIM36 | 394 (19) |
| arsenic trioxide | NA | chemical drug | NA | -1.26e+00 | 0.0e+00 | ATP1B1,AURKA,BACH1,CCND1,CDKN1A,CYP26A1,DHCR24,ETV5,FAS,FASN,FDFT1,GCLM,HMGCS1,IFRD1,IRF1,MADD,MAF,MAPK6,MKNK2,MSMO1,NFE2L2,PFKFB1,PPIF,SQLE,STAT3,TADA3,TFRC,TNFAIP3,XBP1 | 406 (23) |
| BMAL1 | NA | transcription regulator | NA | -1.26e+00 | 0.0e+00 | DBP,FASN,GCK,IHH,LDLR,NFE2L2,PER1,PER2,PPARGC1B,WEE1 | 378 (18) |
| WNT3A | -4.00e-02 | cytokine | NA | -1.26e+00 | 3.0e-02 | ALPL,ATP1B1,BCL2L11,CCND1,CCND2,CD274,CEBPB,CPT2,DDIT4,ETV5,FZD1,GADD45G,Irgm1,JUN,PLD1,PXYLP1,SDC4,SGMS1,SLC7A2,TCF7L2,TGFB1,TNFRSF11B,XBP1,ZNF703 | NA |
| JAK1/2 | NA | group | NA | -1.26e+00 | 0.0e+00 | BAIAP2,CA12,GBP2,Ifgga2l1/RGD1309362,Ifi47,IRF1,ITPKA,MX1,Mx2,RSAD2 | 214 (11) |
| MRTFB | NA | transcription regulator | NA | -1.26e+00 | 3.0e-02 | ADAMTS1,DHCR24,EDNRA,EFNA5,ETV6,GPR37,INHBA,MAFK,NFKBIZ,NREP,NRXN2,PTPRO,RAMP1,S1PR1,SERPINE1 | NA |
| SMPD1 | -1.00e-02 | enzyme | NA | -1.28e+00 | 1.0e-02 | ACKR4,CLCF1,CXCL11,CYP7A1,MAP1LC3B,MAT1A,TGFB1 | NA |
| SNAI1 | 0.00e+00 | transcription regulator | NA | -1.28e+00 | 2.0e-02 | CCND1,CCND2,CCNE1,CDKN1A,CLDN1,CLDN3,FASN,GDF15,HNF4A,ID4,LIMA1,MSI1,SERPINE1,TGFB1 | NA |
| CNR1 | -4.40e-01 | G-protein coupled receptor | NA | -1.29e+00 | 4.0e-02 | ALPL,CYP7A1,DLL1,EGF,FASN,FOXA2,NR3C1,PLD1,PTK6,SOX6,STAT3,TGFB1 | NA |
| SALL4 | 1.00e-01 | transcription regulator | NA | -1.29e+00 | 0.0e+00 | ATP1B1,BTG2,CCND1,CCND2,CHEK2,FBXO15,FZD1,ID2,ID3,JUN,LIMK2,LRP2,MAPK6,RND3,SERPINE1,SYNE1,TNS1 | NA |
| POLR2M | -2.40e-01 | other | NA | -1.29e+00 | 0.0e+00 | BTG2,CCND1,CCNG1,CDKN1A,DDIT4,ENC1,FAS,SESN2 | NA |
| AGTR1 | -4.20e-01 | G-protein coupled receptor | NA | -1.30e+00 | 2.0e-02 | AGT,CCND1,JUN,REN,SERPINE1,TGFB1 | NA |
| lysophosphatidylcholine | NA | chemical - other | NA | -1.31e+00 | 0.0e+00 | CD274,CNTF,FASN,FDFT1,HMGCS1,INSIG1,JUN,LDLR,MSMO1,NLRP3,SERPINE1,SQLE,TGFB1,TNFAIP3 | 401 (23) |
| ETV5 | -6.10e-01 | transcription regulator | NA | -1.32e+00 | 0.0e+00 | AKAP5,CCND1,CDKN1A,CLDN1,CLDN3,ETV5,FASN,LYN,MAF,MID1IP1,NRCAM,PKP2,RGS1,SLC34A2,TINAGL1 | 202 (7) |
| sea cucumber body wall meal | NA | chemical reagent | NA | -1.34e+00 | 0.0e+00 | CPT1A,CYP7A1,FASN,PPARGC1A,PPARGC1B | NA |
| NOP2 | -7.00e-02 | other | NA | -1.34e+00 | 0.0e+00 | ASS1,CDKN1A,GSTT2/GSTT2B,MAP1LC3B,SESN2 | NA |
| TEAD2 | -4.40e-01 | transcription regulator | NA | -1.34e+00 | 0.0e+00 | CCND1,CCNF,EDNRA,GPR37,NFKBIZ,NRXN2,POLA1,PTPRO | 225 (7) |
| TCF7L2 | -6.60e-01 | transcription regulator | NA | -1.34e+00 | 0.0e+00 | ADIPOR2,AKR1C4,ARHGEF26,ASPA,CCND1,CCND2,CDK19,CDKN1A,CLDN2,CREB3L2,CSF3R,CYP7A1,DHCR24,DRAM2,ENC1,FGFR2,GCLM,ID2,ID3,ID4,IHH,JAM3,JUN,LAMA3,LTV1,MOG,NPC1,PIM3,PPARD,PPARGC1A,RASGEF1B,RCBTB1,SLC17A2,STAT3,STX2,TBC1D14,TCF7L2,TNS1,TPPP,TXNDC16,VCAN | 426 (21) |
| lithium chloride | NA | chemical drug | NA | -1.35e+00 | 2.0e-02 | ASS1,BCL3,CCND1,CDKN1A,DLL4,FSCN1,GDF15,HMGCS1,MAP1LC3B,PER1,PLD1,VCAN | NA |
| oxaliplatin | NA | chemical drug | NA | -1.35e+00 | 2.0e-02 | BCL2L11,CCND1,CDKN1A,CHEK2,FAS,GDF15,POLA1,STAT3 | NA |
| SATB2 | -3.70e-01 | transcription regulator | NA | -1.35e+00 | 4.0e-02 | FLVCR2,IFI44,LIMA1,NNMT,NOX4,PLXNA2 | NA |
| miR-122-5p (miRNAs w/seed GGAGUGU) | NA | mature microRNA | NA | -1.37e+00 | 0.0e+00 | AACS,ALDOA,BACH2,CCNG1,CERS6,FOXJ3,GALNT10,GYS1,MAPK11,TRPV6 | NA |
| CDC42 | NA | enzyme | NA | -1.39e+00 | 0.0e+00 | ATF3,BCL2L11,CCND1,CCNE1,JUN,SOX5,STAT3 | 402 (21) |
| citarinostat | NA | chemical drug | NA | -1.39e+00 | 1.0e-02 | CISH,COA7,IFIT3,PDE7A,TSC22D1 | NA |
| IL6ST | -9.00e-02 | transmembrane receptor | NA | -1.39e+00 | 2.0e-02 | CCND1,CLDN2,IL6R,IRF1,JUN,MAF,SERPINE1,STAT3 | NA |
| LG100268 | NA | chemical reagent | NA | -1.39e+00 | 4.0e-02 | BIRC2,CYP7A1,GDF15,LDLR,NR1I2 | NA |
| elaidic acid | NA | chemical - endogenous mammalian | NA | -1.39e+00 | 0.0e+00 | AKR1C4,DHCR24,DHRS3,DLAT,FASN,FDFT1,GNE,HMGCS1,HSD17B2,LDLR,LPIN1,PCSK9,PPP1R3C,SGPL1,SQLE | NA |
| MAPT | 4.40e-01 | other | NA | -1.41e+00 | 0.0e+00 | ACO2,ALDOA,ANKS4B,ASPG,ATF3,ATP1B1,BCL3,CCND1,CD274,CDKN1A,CEBPB,FASN,FGR,Fus,GBP2,GMPS,HSPH1,IFI44,IFIT3,Igtp,IL1RN,IL21R,Irgm1,JUN,LAMA3,MAPK11,MCM10,MOG,MTHFD1,Mx2,Oasl2,PARP14,PLIN4,PPP2CA,SERPINE1,SHROOM3,SYNE1,TGM1,TPPP,TRIM47,TUBA3E,UBC | 404 (20) |
| Stat5 dimer | NA | complex | NA | -1.41e+00 | 1.0e-02 | BIRC3,CCND1,CCND2,IGFALS,SOCS2 | NA |
| BAG1 | -1.00e-01 | other | NA | -1.41e+00 | 1.0e-02 | BCL2L11,CCND1,CDKN1A,FKBP5,JUN,NR3C1 | NA |
| CDKN1A | 3.34e+00 | kinase | NA | -1.41e+00 | 0.0e+00 | AURKA,BIRC2,CCND1,CCNE1,CCNG1,CD274,CDKN1A,EDNRA,FAS,GDF15,ID2,INHBA,IRF6,LAMC1,LIMA1,MAF,MBNL2,NRP2,ORC1,P4HA1,PARP2,RAMP1,RB1,SERPINE1,TGM1,TPST2,VGLL4,WDHD1,WNT4 | 308 (15) |
| CD40LG | -4.00e-02 | cytokine | NA | -1.42e+00 | 0.0e+00 | ATF3,BIRC2,BIRC3,CCNG1,CDKN1A,CYTIP,FAS,FSCN1,ID2,ID3,IFI44,IFIT3,IL15,IL21R,INHBA,IRF1,JUN,MX1,NET1,PAWR,POLA1,PTPN1,RB1,RGS1,SERPINA10,SERPINE1,STAT3,TFRC,TNFAIP3,TNFRSF11B,ZFP36L1 | 406 (18) |
| MEF2D | 2.30e-01 | transcription regulator | NA | -1.42e+00 | 0.0e+00 | BACH2,CCND1,CCNE1,CDT1,GCLM,JUN,MEOX2,NFE2L2,PPARGC1A,SYK,TGFB1 | 277 (7) |
| IL1B | -1.90e-01 | cytokine | NA | -1.43e+00 | 0.0e+00 | ADAMTS1,ALPL,ANKH,ARG1,ASB7,ASS1,ATF3,BCL3,BIRC2,BIRC3,BTG2,C19orf25,CA12,CCND1,CCNF,CCNJ,Cd24a,CD274,CDKN1A,CEBPB,CERS6,CISH,CLDN1,CMPK2,CNTF,CREM,CXCL11,CYP7A1,CYTIP,DBP,DDIT4,DLL1,DLL4,EDNRB,EFNA1,ELAVL1,FAS,FGFR2,FKBP5,FOXO1,FZD1,GADD45B,GBP2,GCK,GDF15,GNA15,GTF2F1,GYS1,HELZ2,HNF4A,HSD17B2,ID2,ID3,IER5L,Ifi47,IFIT3,IFRD1,IGFALS,IGFBP1,IL15,IL15RA,IL17RB,IL1RN,IL33,IL6R,INHBA,IRF1,JUN,LAMA3,LDLR,LGALS9B,MAP2K6,MAPK11,MX1,NFE2L2,NFKBIZ,NFYB,NOCT,NOP56,NR4A2,OAS2,ODC1,PCSK6,PIM3,PLA2G4A,PLD1,PLK3,PPARGC1A,PPARGC1B,PTP4A1,REN,RHOB,RSAD2,S1PR1,S1PR2,SDC4,SERPINB9,SERPINE1,SGPL1,SLC25A25,SLC2A9,SOCS2,STAT3,TFRC,TGFB1,TGM1,TK1,TNFAIP3,TNFRSF11B,UGDH,VCAN,ZC3H12A | 433 (18) |
| IL6 | NA | cytokine | NA | -1.44e+00 | 0.0e+00 | ACER2,ADAMTS1,ADGRL2,AGL,AGT,ARG1,ATF3,BCL2L11,BCL3,BTG2,CCND1,CCNE1,CD274,CDKN1A,CEBPB,CISH,CLDN2,CLEC10A,CSF3R,CYTIP,DUSP6,EPHA4,FAS,FSCN1,GADD45B,GADD45G,GALE,GBP2,ID2,IGFBP1,IL15,IL1RN,IL6R,IRF1,ITPR1,JUN,KLRD1,LDLR,MAF,Mt1m/Mt2A,NFE2L2,NR1I2,NR3C1,RB1,ROR1,S1PR1,S1PR2,SERPINA7,SERPINE1,SMOX,SOCS2,SOX6,STAT3,STOM,TFRC,TGFB1,TK1,TLR6,TNFRSF11B,WEE1,WNT4,XBP1 | 410 (17) |
| NFATC2 | -1.00e-01 | transcription regulator | NA | -1.45e+00 | 0.0e+00 | BCL2L11,CCNE1,CCNF,CD274,CDKN1A,CISH,CMPK2,FAS,HELZ2,IFIT3,IL15,INHBA,IRF1,ITPR1,JUN,LMO4,MAF,Mx2,NFKBIZ,NOX4,PLD1,PPARGC1A,PTPN1,RGS1,RSAD2,SLC3A2,SOCS2,TGFB1,TSC22D1 | 421 (18) |
| IFN alpha/beta | NA | group | NA | -1.45e+00 | 0.0e+00 | BCL2L11,CLEC10A,IFIT3,IL15,IL15RA,IRF1,Irgm1,Mx2,RSAD2,SERPINB9 | 340 (16) |
| mir-33 | NA | microRNA | NA | -1.47e+00 | 0.0e+00 | AGT,CPT1A,GCK,PPARGC1A,PRKAA1 | NA |
| HFE | 1.60e-01 | transmembrane receptor | NA | -1.47e+00 | 0.0e+00 | ALPL,BHLHE40,CISH,GADD45G,GSTT2/GSTT2B,HHEX,HMGCS1,HSPH1,IL6R,LPIN1,MCM10,MFSD2A,PPP1R3C,TFRC | 85 (4) |
| JAK2 | 0.00e+00 | kinase | NA | -1.49e+00 | 0.0e+00 | ACER2,BCL2L11,CCND1,CCND2,CD274,CDKN1A,FOXO1,GBP2,IRF1,LYN,NFKBIZ,ODC1,SDC4,SEMA6B,STAT3,TP53INP1,TSC22D1 | 271 (18) |
| AKT2 | -1.30e-01 | kinase | NA | -1.50e+00 | 0.0e+00 | BCL2L11,CDKN1A,CEBPB,FOXO1,GCLM,MTSS1,PALLD,TGFB1 | 416 (24) |
| MGP | 2.20e-01 | other | NA | -1.50e+00 | 0.0e+00 | CD274,HHEX,HNF1A,HNF4A,IL15,IL15RA,MAP3K14,PAH | 150 (7) |
| HMG20A | 3.60e-01 | transcription regulator | NA | -1.50e+00 | 0.0e+00 | ATF3,FASN,FDFT1,HMGCS1,IL15RA,INHBA,JUN,LDLR,NNMT,RTP4,SDC4,SERPINE1,SQLE,TGFB1,TNFRSF11B,VCAN | 207 (7) |
| ATP7B | -1.00e-02 | transporter | NA | -1.51e+00 | 0.0e+00 | AACS,AMACR,CCNG1,CYP7A1,FASN,FDFT1,HMGCS1,LDLR,LPIN1,MSMO1,SQLE | NA |
| IRF6 | -8.10e-01 | transcription regulator | NA | -1.51e+00 | 1.0e-02 | ARG1,CD274,CLEC10A,NLRP3,NR4A2,PPARGC1A,PPARGC1B,SLC7A2 | 321 (15) |
| TP53 | -4.00e-02 | transcription regulator | NA | -1.52e+00 | 0.0e+00 | ACER2,ACO2,ALDOA,ANKH,APEX1,ARG1,ASL,ASNS,ASS1,ATF3,AURKA,BCL2L11,BCL3,BCL6B,BHLHE40,BIRC2,BIRC3,BTG2,CARD10,CCND1,CCND2,CCNE1,CCNF,CCNG1,CDKN1A,CDT1,CEBPB,CERS6,CGREF1,CHEK2,CHMP4C,COX10,CPT1A,CPT2,CSF3R,CTIF,DBP,DBT,DDB2,DDIT4,DFFB,DHCR24,DLAT,DNAJC11,DUSP6,DYNLL1,EDNRA,EFNA1,EGF,Esrra,FAS,FASN,FDFT1,FKBP5,FOXA2,FOXO1,GADD45B,GADD45G,GART,GDF15,GNA14,GNL3,GPD1L,GPR157,HDAC2,HMGCS1,HSPH1,ID2,ID3,IFI44,IFI44L,IFIT3,IL1RN,IL21R,IL33,INHBA,IRF1,ITSN1,JUN,KPNA2,LAMC1,LDLR,LIMA1,LIMK2,LPIN1,MAFB,MAP1LC3B,MAP2K6,MAPK6,MBNL2,MTMR11,MX1,NLRP12,NOLC1,NOX4,NR2C1,NUCKS1,NUPR1,ODC1,OSGIN1,P4HA1,PALLD,PARP2,PAWR,PDSS1,PFKFB1,PFKFB3,PHLDB3,PIK3R1,POLA1,PPARD,PPARGC1A,PPARGC1B,PPP1R13B,PPP2CA,PRKAG2,PTP4A1,PTPN1,PTPRO,PYCARD,RAD17,RB1,RBM3,RECQL4,RHOB,RHOF,RND3,RNF144B,RPRM,RPS18,RSAD2,SERPINB9,SERPINE1,SESN2,SGPL1,SGTB,SHROOM3,SLC19A2,SLC2A9,SLC7A5,SOCS2,SQLE,STAT3,STOM,TCF7L2,TDO2,TFRC,TGFB1,TIMM10,TINAGL1,TLR6,TOMM40,TP53I13,TP53INP1,UBC,UBE2D1,UGDH,UNC5B,VANGL1,VCAN,VMP1,VRK1,WDHD1,WEE1,WNT4,XBP1,ZC3H12A,ZFP36L1 | 410 (19) |
| RUNX2 | -4.80e-01 | transcription regulator | NA | -1.52e+00 | 1.0e-02 | ALPL,CCND1,CCNE1,CDKN1A,FGFR2,GADD45B,IHH,SERPINE1,SOX5,SOX6,ST3GAL5,TNFRSF11B | NA |
| CSHL1 | NA | growth factor | NA | -1.52e+00 | 1.0e-02 | CISH,FOXA2,HNF4A,IGFBP1,IRF1,ONECUT1,PIK3R1,SOCS2 | 401 (23) |
| REL | 1.90e-01 | transcription regulator | NA | -1.52e+00 | 1.0e-02 | BACH2,BCL3,CCND1,CCND2,CDKN1A,CREM,DCLRE1B,ETV5,FAS,GADD45B,INSC,IRF6,JUN,NFE2L2,PARP14,PYCARD,RSAD2,SLC25A27,STAT3,TNFAIP3 | 396 (20) |
| Jnk | NA | group | NA | -1.54e+00 | 1.0e-02 | AGT,BCL2L11,BIRC3,CCND1,CCNE1,CLDN2,CLEC10A,FAS,GDF15,HNF4A,JUN,NFE2L2,NOX4,PPARD,SERPINE1,SESN2,TGFB1,TINAGL1,VCAN | 362 (20) |
| CDK5 | -1.40e-01 | kinase | NA | -1.54e+00 | 2.0e-02 | CD274,CDKN1A,JUN,TNFAIP3,XBP1 | NA |
| SREBF2 | -4.40e-01 | transcription regulator | NA | -1.54e+00 | 0.0e+00 | AACS,CDKN1A,FABP7,FASN,FDFT1,HMGCS1,INSIG1,LDLR,MSMO1,NLRP3,PCSK9,PCYT1A,SQLE | 345 (18) |
| Map3k7 | NA | kinase | NA | -1.55e+00 | 0.0e+00 | BHLHE40,CMPK2,FASN,ID4,IL15,IL15RA,JUN,Mx2,NFKBIZ,RSAD2,TSC22D1 | 356 (19) |
| IFN Beta | NA | group | NA | -1.55e+00 | 0.0e+00 | ATF3,BTG2,CD274,CDKN1A,CEBPB,CMPK2,CXCL11,FKBP5,IFI44,IFIT3,IL15,IL15RA,IL1RN,INSIG1,IRF1,MX1,Mx2,Oas1b,OAS2,RAB30,RSAD2,SERPINE1,SLC16A6,SOX5,TDO2,TGFB1 | 319 (15) |
| IRF9 | -2.30e-01 | transcription regulator | NA | -1.57e+00 | 0.0e+00 | CD274,CMPK2,HELZ2,Ifi47,IFIT3,IRF1,MX1,OAS2,Oasl2,PARP14,RSAD2,RTP4,STAT3 | 245 (13) |
| tert-butyl-hydroquinone | NA | chemical reagent | NA | -1.57e+00 | 0.0e+00 | AGL,ATF3,BACH1,GCLM,HERPUD1,HNF1A,JUN,MAF,NFE2L2,OSGIN1,PALLD,SERPINE1,SESN2,ZNF184 | 414 (24) |
| palbociclib | NA | chemical drug | NA | -1.58e+00 | 0.0e+00 | ATF3,CCND1,CD274,CDKN1A,CDT1,GADD45B,ID2,IFI44,JUN,MX1,NR4A2,PER1,RHOB,TK1 | 452 (26) |
| Vegf | NA | group | NA | -1.60e+00 | 0.0e+00 | ACKR4,Acot1,ADAMTS1,ADGRL2,ASNS,ATF3,AURKA,BCL2L11,CCNF,CDC14A,CLCF1,CLDN1,CXCL11,DLL4,DUSP6,EFNA1,EPHA4,ETV5,FAS,FKBP5,FNDC3A,HERPUD1,IGFBP1,IHH,IL15RA,INHBA,INSIG1,IRF1,ITPR1,JUN,LDLR,LPAR6,LRIG1,LRP2,LYN,MEOX2,MPHOSPH10,NLRP12,NOLC1,NPC1,NR4A2,NRCAM,PKDCC,PLXNA2,PPARD,PPARGC1A,PRKAA1,SCML4,SLC19A2,SLC7A2,SOCS2,STAT3,STC1,TBC1D8,TGFB1,TNFRSF11B | 423 (22) |
| Akt | NA | group | NA | -1.60e+00 | 0.0e+00 | BCL2L11,BHLHE40,BIRC2,BTG2,CCND1,CCND2,CD274,CDKN1A,CEBPB,CHST3,CPT1A,DLL4,EXT1,FAS,FASN,FKBP5,FOXO1,GALNT10,GCK,HIF3A,HIGD1A,JUN,LAMA3,MSI1,MSLN,NET1,NFE2L2,NOX4,NPC1,NRP2,PLA2G4A,PPARD,PPARGC1A,PTTG1IP,RB1,RHOB,SERPINE1,SLC7A5,ST3GAL6,VCAN,XBP1 | 477 (25) |
| LCN2 | 3.70e-01 | transporter | NA | -1.60e+00 | 0.0e+00 | ARG1,FAS,FASN,IL15,IL1RN,LDLR,PNPLA2,PPARGC1A,TGFB1,TINAGL1,TNFRSF11B | 424 (23) |
| KAT5 | 2.00e-01 | transcription regulator | NA | -1.60e+00 | 0.0e+00 | ADAMTS1,APEX1,BIRC2,CACNB2,CCND1,CCND2,CDKN1A,CHKA,ERLIN1,FOXA2,GADD45B,GNPNAT1,HERPUD1,HNF4A,NPC1,PALMD,PCDH20,RGS1 | 425 (23) |
| DOCK8 | -1.00e-02 | other | NA | -1.60e+00 | 0.0e+00 | CCND2,CMPK2,HELZ2,IFIT3,IL15,IL15RA,INHBA,IRF1,LMO4,Mx2,NFKBIZ,RGS1,RSAD2,TSC22D1 | NA |
| NC410 | NA | biologic drug | NA | -1.60e+00 | 0.0e+00 | ATF3,BTG2,CD274,CDKN1A,CLEC10A,CMPK2,EDNRB,GADD45B,IRF1,PARP14,RGS1,RSAD2,STAT3,TGFB1 | NA |
| Interferon alpha | NA | group | NA | -1.61e+00 | 0.0e+00 | ADAMTS1,ASNS,ATF3,BCL3,BTG2,CBLB,CCND1,CCND2,CD274,CDKN1A,CISH,CXCL11,DDIT4,DUSP6,EDEM1,FAS,FASN,FMO3,GBP2,GNA15,HELZ2,IFI44,IFI44L,Ifi47,IFIT3,IL15,IL15RA,IL1RN,IL21R,IL6R,IRF1,ITPR1,MX1,Oas1b,OAS2,Oasl2,PARP14,PARP9,PPM1K,RB1,RGS1,RSAD2,RTP4,SERPINB9,SF3A1,SOCS2,STAT3,TGFB1,TGM1,TMEM140,TSC22D1,VCAN,XBP1 | 318 (13) |
| Immunoglobulin | NA | complex | NA | -1.62e+00 | 0.0e+00 | ACO2,ADRA1B,AGT,ALDOA,Apol9a/Apol9b,ARG1,BCL2L11,BCL3,BIRC3,CBS/LOC102724560,CCND1,CCND2,CCNE1,CD274,CD300LF,CEBPB,CHEK2,CISH,CMPK2,CPT1A,CXCL11,CYP7A1,DDIT4,DLAT,DUSP6,EDNRB,ETV5,EXT1,FAS,FASN,FGFR2,FKBP5,FOXA1,FOXO1,GCK,GYS1,HAO2,HELZ2,IDH3A,IFIT3,IL15,IL15RA,IL17RB,IL1RN,IL33,INHBA,IRF1,KLRD1,LAMC1,LDLR,LILRB3,MAF,MAP1LC3B,MAP3K14,MFSD2A,MICAL2,MTHFD1,MX1,Mx2,NFE2L2,NFKBIZ,NLRP3,Oas1b,OAS2,PARP14,PDE3B,PIK3IP1,PIK3R1,PLIN4,PLK3,PNPLA2,PPARGC1A,PTK6,PYCARD,RB1,RSAD2,S1PR1,SAMD11,SIRPA,SLC30A2,SLC3A2,SLC7A5,SMOX,SQLE,STAT3,TCF7L2,TFRC,TGFB1,TNFRSF11B,UGP2,VCAN,VSIR,XBP1 | 471 (20) |
| RBL1 | 1.20e-01 | transcription regulator | NA | -1.62e+00 | 1.0e-02 | BCL2L11,CCND1,CCNE1,CDKN1A,FAS,MCM10,ORC1,PPARGC1A,RB1 | 402 (21) |
| (-)-norephedrine | NA | chemical drug | NA | -1.63e+00 | 0.0e+00 | FDFT1,HMGCS1,LDLR,MSMO1,NPC1,SQLE | 157 (8) |
| trichloroethylene | NA | chemical toxicant | NA | -1.63e+00 | 5.0e-02 | CCNG1,DHCR24,ID2,PLD1,RHOB,STOM | NA |
| EZH2 | -6.00e-02 | transcription regulator | NA | -1.64e+00 | 0.0e+00 | ABL2,ALPL,AMACR,ATF3,BCL2L11,BIRC3,CCND1,CCND2,CCNE1,CDKN1A,CEMIP,CSF3R,CXCL11,DENND2A,EFNA1,FANCB,FGF11,FKBP5,FOXA1,FZD1,GDF15,GSTM4,IGFBP1,IL6R,MCM8,NOX4,PARP9,PCDH20,PER1,PER2,PIK3IP1,PLA2G4A,POU2F3,PPP2R2B,RAC3,RB1,SGPL1,TGFB1 | 432 (21) |
| diethylnitrosamine | NA | chemical toxicant | NA | -1.64e+00 | 0.0e+00 | ARG1,BAAT,BCL2L11,BIRC2,BIRC3,CCND1,CCND2,CDKN1A,CPT2,CYP26A1,GSTM4,HNF4A,IGFBP1,JUN,NFE2L2,PAH,PPARGC1A,SELENBP1,SESN2,SLC22A25,STAT3,TGFB1,UPP2 | 411 (22) |
| PIK3CD | -3.90e-01 | kinase | NA | -1.66e+00 | 0.0e+00 | ASNS,BCL2L11,CCND2,CCNE1,EDEM1,HDAC2,MAF,TGFB1 | 447 (23) |
| APP | -4.00e-02 | other | NA | -1.67e+00 | 0.0e+00 | ACO2,ALDOA,ANKS4B,ARG1,ARRDC3,ATP1B1,ATP2B2,BCL2L11,BRPF1,CA12,CCND1,CCND2,CCNE1,CDC14A,CDKN1A,CEBPB,CLDN1,CMPK2,EXT1,Fus,FZD1,GBP2,GDF15,HERPUD1,Ifi47,Igtp,IL15,INHBA,IRF1,Irgm1,JUN,LDLR,LMO4,LPAR6,MADD,MAF,MAFB,MCM10,Mx2,NCDN,NLRP3,NR4A2,NRP2,Oas1b,PARP14,PFKFB3,PIK3R1,PPARD,PPP2CA,PYCARD,RAMP1,RBM3,RNF144B,RSAD2,RTP4,S1PR1,SDC4,Serpinb6b,SERPINE1,SIRPA,ST3GAL5,STAT3,TGFB1,TNFRSF11B,TOR3A,TP53INP1,TPPP,TUBA3E,UBC,VCAN,WNT4,ZFP36L1 | 368 (19) |
| GIP | NA | other | NA | -1.67e+00 | 1.0e-02 | ATF3,GBP2,Ifi47,IFIT3,IL1RN,PPARGC1A,RSAD2,SERPINE1 | 451 (28) |
| SCAP | -1.30e-01 | other | NA | -1.67e+00 | 0.0e+00 | AACS,ASNS,ATF3,FASN,FDFT1,HMGCS1,INSIG1,LDLR,MSMO1,PCSK9,SQLE | 174 (11) |
| IL21 | NA | cytokine | NA | -1.68e+00 | 0.0e+00 | ARG1,BCL2L11,CCND2,CDKN1A,CMPK2,ID2,IFIT3,Igtp,IL21R,Irgm1,KLRD1,Mx2,OAS2,RSAD2,SOCS2,STAT3,TGFB1,XBP1 | 394 (20) |
| doxorubicin | NA | chemical drug | NA | -1.68e+00 | 0.0e+00 | ADAMTS1,APEX1,ASAP3,ASNS,ATF3,AURKA,BCL2L11,BHLHE40,BIRC2,BIRC3,BTG2,CCND1,CD274,CDKN1A,CGREF1,CHEK2,CHRDL1,CREM,Ctla2a,DDIT4,Esrra,FAS,FGF11,GDF15,GTPBP4,HAND2,HSPH1,ID2,IGFBP1,INHBA,IRF1,JUN,LIMA1,LPIN1,MBNL2,NFE2L2,NLRP3,NOX4,ODC1,OSGIN1,PINX1,PRKAA1,RB1,RBM3,RGS7,RPRM,SLC19A2,SLC34A2,STAT3,TBC1D8,TGFB1,TK1,TNFRSF14,TP53INP1,WNT4 | 393 (19) |
| DDX17 | NA | enzyme | NA | -1.70e+00 | 1.0e-02 | CCND1,CDKN1A,JUN,NET1 | 311 (7) |
| D-galactosamine | NA | chemical - endogenous mammalian | NA | -1.70e+00 | 2.0e-02 | EDNRA,GDF15,IL33,JUN,NFE2L2,NLRP3 | NA |
| SKI | -4.00e-01 | transcription regulator | NA | -1.71e+00 | 0.0e+00 | CDKN1A,CYP26A1,NRCAM,ODC1,SERPINE1 | 150 (9) |
| flutamide | NA | chemical drug | NA | -1.71e+00 | 0.0e+00 | B4GALNT1,Chn1,CYP17A1,EGF,FOXO1,HNF1A,Hsd3b4 (includes others),NR3C1,ODC1,REN,TGFB1 | 522 (20) |
| ezetimibe | NA | chemical drug | NA | -1.71e+00 | 1.0e-02 | CPT1A,FAS,FDFT1,HMGCS1,LDLR,PCSK9 | 137 (7) |
| bromodeoxyuridine | NA | chemical drug | NA | -1.71e+00 | 3.0e-02 | IFI44,IFIT3,INHBA,IRF1,MX1,SERPINE1 | NA |
| PLAT | 4.10e-01 | peptidase | NA | -1.71e+00 | 2.0e-02 | CCND1,INHBA,JUN,SERPINE1,TGFB1 | NA |
| IFNG | NA | cytokine | NA | -1.73e+00 | 0.0e+00 | ABTB2,Acot1,ADGB,ADGRG2,AGT,ALPL,ARG1,ASNS,ASS1,ATF3,ATP1B1,BACH1,BACH2,BCL2L11,BCL3,BIRC2,BIRC3,CCND1,CCND2,Cd24a,CD274,CDKN1A,CEBPB,CEP85,CERS6,CHST3,CIRBP,CISH,CLEC10A,CMPK2,CREM,CXCL11,CYTIP,DBP,DDB2,DLL1,DTX3L,DUOX2,EDNRA,EDNRB,EGF,ELAVL1,EXT1,FAS,FASN,FKBP5,FOXO1,FZD1,GADD45B,GART,GBP2,GCK,GDF15,GNA14,GPR146,HMGCS1,ID2,IFI44,IFI44L,Ifi47,IFIT3,IFRD1,Igtp,IL15,IL15RA,IL17RB,IL1RL2,IL1RN,IL6R,INHBA,IRF1,Irgm1,ITPR1,JUN,LAMC1,LDLR,LGALS9B,LYN,LZTS1,MAF,MFSD2A,MTSS1,MX1,Mx2,NFKBIZ,NLRP3,NOX4,NUP98,NUPR1,Oas1b,OAS2,Oasl2,ODC1,PARP14,PARP9,PDE3B,PFKFB3,PIM3,PLD1,PPARD,PPARGC1A,PPARGC1B,PTPN1,RAD18,RARRES1,RB1,RFX5,RGS1,RHOB,RRAGD,RSAD2,RTP4,S1PR1,S1PR2,SDC4,SDCCAG8,SERPINB9,SERPINE1,SF3A1,SGPL1,SLC12A3,SLC7A5,SOCS2,SQLE,STAT3,TCF7L2,TFRC,TGFB1,TGM1,TLR6,TMEM140,TNFRSF11B,TNFRSF14,UBE2D1,UNC5B,ZNF81 | 342 (16) |
| 1,1-diarylethylene-diammonium derivative | NA | chemical reagent | NA | -1.73e+00 | 0.0e+00 | AURKA,CDKN1A,FAS,HELZ2,IFI44,IFIT3,OAS2,PARP14,PARP9,ST3GAL5,TMEM140,TNFAIP3 | NA |
| KDM5B | -1.30e-01 | transcription regulator | NA | -1.73e+00 | 0.0e+00 | AURKA,CCND1,CCNE1,CDC14A,CLCF1,CLDN1,DHCR24,FGFR2,FOXA1,ID2,INSIG1,LRCH4,PDE3B,REEP1,SMOX,TGFB1,UBR7,XBP1 | 345 (16) |
| LDL | NA | complex | NA | -1.74e+00 | 0.0e+00 | ATF3,BCL2L11,CBS/LOC102724560,CCND1,CDKN1A,CREM,CXCL11,DLL4,EDNRB,FAS,FASN,GCLM,IL1RN,INSIG1,ITPR1,JUN,LDLR,MX1,NLRP3,NPC1,NR4A2,OSCAR,RND3,SERPINE1,STAT3,TGFB1,TNFAIP3,XBP1 | 496 (22) |
| AGT | 8.70e-01 | growth factor | NA | -1.74e+00 | 0.0e+00 | ADAMTSL2,AGT,AKAP5,ANGPTL8,ARG1,ASL,ATF3,ATP1B1,ATP2B2,BACH1,BHLHE40,CBS/LOC102724560,CCND1,CCND2,CCNE1,CCNF,CDKN1A,CGREF1,CREM,CYP17A1,DLL4,EDNRA,EDNRB,EFNA5,ETV5,FASN,FDFT1,FGR,FKBP5,FZD1,GDF15,HMGCS1,ID3,IL15,IRF6,JUN,KCNJ8,KLF15,LDLR,MAFB,MKNK2,MSMO1,NFE2L2,NLRP3,NOX4,NR4A2,NREP,PALLD,PAWR,PIK3R1,PKP2,PPARGC1A,PPP1R3C,Rcan1,REN,RIPK3,SCUBE3,SERPINA10,SERPINE1,SLC10A6,SLC12A3,SLC34A2,SOX6,STC1,TFRC,TGFB1,TNFRSF11B,TNS1,UNC5B | 488 (25) |
| PTK2 | -1.10e-01 | kinase | NA | -1.74e+00 | 3.0e-02 | BIRC2,BIRC3,CCND1,CDKN1A,LDLR,P4HA1,PALLD | NA |
| BMP2 | -3.80e-01 | growth factor | NA | -1.75e+00 | 0.0e+00 | ADAMTS7,ALPL,BHLHE40,CCND1,CDKN1A,CHRNA2,CLDN3,CYP17A1,EGF,EPHX2,FGFR2,FOXO1,FZD1,GADD45B,ID2,ID3,ID4,IHH,INHBA,JUN,KLF9,NFYA,NFYB,PCSK6,PLXNA2,SOX6,TNFRSF11B,VCAN,WNT4 | 384 (19) |
| IL12 (complex) | NA | complex | NA | -1.75e+00 | 5.0e-02 | BCL3,CISH,CXCL11,CYTIP,DDB2,FAS,GADD45B,GADD45G,IL15,IRF1,JUN,KLRD1,SOCS2,TFRC,TGFB1 | NA |
| PKD1 | 4.00e-02 | ion channel | NA | -1.76e+00 | 5.0e-02 | ATP1B1,CDKN1A,CLCF1,FOXO1,IL17RB,NNMT,PAH,RGS3,SLC13A2,SLC16A4,SLC2A9,SOX6,SYNE1,TNFRSF11B,TNS1 | NA |
| TICAM1 | NA | other | NA | -1.77e+00 | 0.0e+00 | BCL3,CMPK2,CXCL11,EDNRB,FAS,GDF15,Ifi47,IFIT3,Igtp,IL15,IL15RA,IRF1,Irgm1,Mx2,NFKBIZ,NOX4,RHOB,RSAD2,SERPINE1,SLC7A2,TNFAIP3,TSC22D1 | 179 (17) |
| SHH | -2.00e-02 | peptidase | NA | -1.77e+00 | 1.8e-01 | ADAMTS1,AMD1,CCND1,CCND2,CCNE1,CTPS1,FOXA1,FOXA2,HAND2,IHH,NOX4,SERPINE1 | NA |
| PRKCA | -3.00e-02 | kinase | NA | -1.78e+00 | 0.0e+00 | CCND1,CCNE1,CDKN1A,FASN,FOXO1,GDF15,ID2,ID3,IFIT3,INSIG1,JUN,PLD1,RB1,RSAD2,SERPINE1 | 416 (24) |
| chenodeoxycholic acid | NA | chemical - endogenous mammalian | NA | -1.78e+00 | 1.0e-02 | AGT,CPT1A,CYP7A1,FASN,HNF1A,HNF4A,LDLR,LRP2,SLCO1B3,TK1 | NA |
| IRF8 | -1.80e-01 | transcription regulator | NA | -1.79e+00 | 0.0e+00 | ATF3,CDKN1A,CREM,CSF3R,ETV6,FAS,GNA15,HCN3,ID3,IFI44L,IFIT3,IL15,IL1RN,MAF,MAFB,OAS2,Oasl2,STX2,TK1 | 374 (19) |
| MAP4K4 | -2.80e-01 | kinase | NA | -1.80e+00 | 0.0e+00 | ACO2,AGL,CBLB,CEBPB,COX10,DLAT,FASN,GOT1,GYS1,MAFB,PEX11A,PEX16,PTDSS2 | NA |
| PDGF BB | NA | complex | NA | -1.80e+00 | 0.0e+00 | ATF3,BCL3,BHLHE40,BRAP,CCND1,CCNE1,CDKN1A,CEBPB,DUSP6,EDNRB,ELAVL1,FASN,FZD1,GBP2,GDF15,HMGCS1,ID3,INHBA,JUN,LDLR,MAFK,NOX4,NR4A2,ODC1,Omd,PAWR,PPARD,RGS1,RHOB,RND3,S1PR2,SERPINE1,STAT3,SYK,SYNE1,TGFB1,TIMM17A,TNFAIP3,TNFRSF11B,UGDH,UNC5B,VCAN,ZFP36L1 | 426 (20) |
| 26s Proteasome | NA | complex | NA | -1.80e+00 | 0.0e+00 | ARG1,BCL2L11,BCL3,BIRC2,BIRC3,CDKN1A,EGF,FOXO1,MAP1LC3B,POLA1,PPP2CA,RB1,S1PR1,TK1,VPS18 | 400 (20) |
| MUC1 | NA | other | NA | -1.80e+00 | 1.3e-01 | ARG1,CCND1,CCND2,FASN,IFIT3,Mx2,XBP1 | NA |
| SAMSN1 | -2.60e-01 | other | NA | -1.81e+00 | 0.0e+00 | CCND2,CMPK2,HELZ2,IFIT3,IL15,IL15RA,INHBA,IRF1,LMO4,Mx2,NFKBIZ,RSAD2,TSC22D1,XBP1,ZC3H12A | 194 (7) |
| ibrutinib | NA | chemical drug | NA | -1.81e+00 | 0.0e+00 | ALDOA,ASNS,DHRS3,FAS,GNL3,LPAR6,MAP3K6,NDUFAF4,NECTIN1,NOLC1,NRIP1,ODC1,RCBTB2,RRP12,TBRG4 | NA |
| colchicine | NA | chemical drug | NA | -1.81e+00 | 5.0e-02 | ATF3,FAS,JUN,MX1,NR1I2,TAT | NA |
| sodium bisulfide | NA | chemical reagent | NA | -1.81e+00 | 2.0e-02 | AGT,CCNG1,CDKN1A,FAS,LAMC1,NOX4,SESN2 | NA |
| etoposide | NA | chemical drug | NA | -1.82e+00 | 0.0e+00 | ATF3,BCL2L11,BIRC2,BIRC3,CCND1,CD274,CDKN1A,CROCC,CXCL11,DDIT4,DFFB,FAS,FASN,GADD45G,GBP2,GDF15,ID2,IFI44L,IRF1,JUN,LIMA1,LPAR6,OAS2,ODC1,RNF144B,SLC16A4,TK1,TNFAIP3 | 368 (18) |
| UBR5 | NA | enzyme | NA | -1.83e+00 | 0.0e+00 | CCND1,CD274,CDKN1A,IFIT3,IL15,IL17RB,IL1RL2,IRF1,OAS2 | 285 (10) |
| FGF7 | -2.00e-01 | growth factor | NA | -1.84e+00 | 0.0e+00 | CCND1,CDKN1A,CYP7A1,ETV5,FASN,FGFR2,IRF1,NFE2L2,SERPINE1,TGFB1 | 365 (22) |
| SPIB | -2.60e-01 | transcription regulator | NA | -1.84e+00 | 1.0e-02 | ARHGAP6,ATF3,CLEC10A,DLL1,GNA15,LILRB3,NET1,NRXN2,P2RY10,TNFRSF11B,XBP1 | NA |
| HDAC1 | 1.00e-02 | transcription regulator | NA | -1.85e+00 | 2.0e-02 | APEX1,ATF3,CCND1,CCND2,CCNE1,CDKN1A,CDT1,FAS,MCM10,OSCAR,PAX8,PCYT1A,PFKFB3,PPARGC1A,PPP2R2B,RECQL4,RHOB,SERPINE1,STAT3,TDRKH,TNS1 | NA |
| lipopolysaccharide | NA | chemical drug | NA | -1.85e+00 | 0.0e+00 | 9930111J21Rik1/Gm12185,Acot1,ADAMTS1,ADGB,AGT,ALDOA,APEX1,ARG1,ARL4A,ARRDC3,ASAP3,ASS1,ATF3,ATXN7L1,BACH2,BCL2L11,BCL3,BIRC2,BIRC3,CBLB,CCND1,CCND2,CCNE1,CCNF,CD180,Cd24a,CD274,CD300LF,CD79B,CDKN1A,CEBPB,CEMIP,CEP85,CHD7,CHST3,CISH,CLDN1,CLDN3,CLEC10A,CMPK2,CPT1A,CREB3L2,CREM,CSF3R,CXCL11,CYP7A1,CYTIP,DDIT4,DHCR24,DLL1,DLL4,DTX3L,EDEM1,ELAVL1,ELL2,EPHX2,Esrra,ETV5,ETV6,EXT1,FAS,FASN,FNDC3A,FOXA1,FOXA2,FOXO1,FSCN1,FZD1,GADD45B,GADD45G,GBP2,GCLM,GDF15,GNA15,GNL3,GSE1,GSTT2/GSTT2B,GYS1,HDAC2,HERPUD1,HHEX,HIVEP1,HNF1A,HNF4A,ID2,ID3,IFI44,IFI44L,Ifi47,IFIT3,IFRD1,IGFBP1,Igtp,IL15,IL15RA,IL1RL2,IL1RN,IL21R,IL33,IL6R,INHBA,INPP5B,INSIG1,IRF1,Irgm1,ITGA9,JUN,LDLR,LIMK2,LMNB1,LMO4,LPIN1,LYN,LYSMD2,MAF,MAFB,MAP1LC3B,MAP3K6,MAPK11,MAPK6,MBL2,MCM10,MKNK2,MTSS1,MX1,Mx2,NFE2L2,NFKBIZ,NLRP3,NNMT,NOCT,NOX4,NR1I2,NR3C1,NR4A2,NRP2,NUPR1,OAF,Oas1b,OAS2,Oasl2,ODC1,OSCAR,P4HA1,PARP14,PARP9,PAWR,PCSK6,PDE3B,PFKFB3,PIK3R1,PLA2G4A,PLD1,PLEKHA4,PLIN4,PLK3,POLA1,PPARD,PPARGC1A,PPARGC1B,PPP1R13B,PRKAA1,PRRG4,PTPRO,PYCARD,RASGEF1B,RASL11A,RB1,RDH13,RGS1,RGS7,RHOB,RND3,RSAD2,RTP4,S1PR1,S1PR2,SARM1,SDC4,SEC24D,SECTM1,SERPINB9,SERPINE1,SIRPA,SLC16A10,SLC25A34,SLC38A2,SLC3A2,SLC7A2,SLC7A5,SLCO1B3,SOCS2,SSBP3,ST3GAL5,STAT3,STX2,SULT1B1,TCF7L2,TDO2,TELO2,TFRC,TGFB1,THRB,TLR6,TMEM140,TNFAIP1,TNFAIP3,TNK2,TOR3A,TPST2,TRIM6-TRIM34,TSC22D1,UNC119,VCAN,VSIR,WEE1,XBP1,ZC3H12A,ZNFX1 | 499 (20) |
| TLR9 | 4.70e-01 | transmembrane receptor | NA | -1.85e+00 | 0.0e+00 | ATF3,CCND1,CD274,CERS6,CISH,FAS,GADD45B,IFI44L,IFIT3,IL21R,IL33,IRF1,LYST,MX1,NFKBIZ,OAS2,Oasl2,PFKFB3,PYCARD,RSAD2,SERPINE1,SGPL1,ST3GAL5,TGFB1,XBP1 | 364 (16) |
| GATA4 | -5.10e-01 | transcription regulator | NA | -1.87e+00 | 4.2e-01 | ASS1,CA12,CLDN1,CLDN2,CYP17A1,HAO2,INHBA,IRF6,JUN,PLIN4,PPL,SGPL1,SLC25A29 | NA |
| decitabine | NA | chemical drug | NA | -1.87e+00 | 0.0e+00 | ADAMTS1,ADGRL2,ALS2,BAIAP2,BCL2L11,BIRC3,CA12,CCND1,CCND2,CD79B,CDKN1A,CGREF1,CYP17A1,CYP26A1,DHRS3,FAS,FOXA1,GADD45B,GADD45G,GCK,GDF15,GPR37,HNF4A,HNRNPD,IRX1,KLF11,LAMA3,LDLR,LMNB1,LRIG1,MAF,MAFB,MAT1A,MSI1,MX1,MYO1B,NECTIN1,NR3C1,NR4A2,NUCKS1,PAWR,PER2,PKP2,PSAT1,RARRES1,RASSF3,RB1,RPRM,RTP4,SIRPA,SLCO1B3,STAT3,SYK,TFRC,TSC22D1,UGDH,VCAN,VSIR,WDR77 | 461 (20) |
| T-5224 | NA | chemical reagent | NA | -1.89e+00 | 0.0e+00 | ABTB2,ADAMTS1,ARHGAP6,CDK19,DUOX2,DUSP6,FKBP5,GADD45B,GYS1,HMGCS1,ID2,INHBA,JUN,PFKFB3,RAPH1,SQLE,TNS1,UGP2 | NA |
| CST5 | NA | other | NA | -1.89e+00 | 8.0e-02 | ARHGAP29,CEMIP,EVA1C,GNL3,ID3,LAMC1,MRM3,NIFK,NR3C1,NUP98,PPL,RBM3,SGPL1,SRSF4,TOMM40,VCAN,WDR3,WDR77 | NA |
| CYP1A2 | -2.00e-02 | enzyme | NA | -1.89e+00 | 0.0e+00 | CCND1,CYP17A1,CYP26A1,ETHE1,INSC,SOCS2,WEE1 | 297 (7) |
| CYP1A1 | 1.50e-01 | enzyme | NA | -1.89e+00 | 1.0e-02 | CCND1,CYP17A1,CYP26A1,ETHE1,INSC,ODC1,PTP4A1,SOCS2,TMPO,TSC22D1,WEE1 | 396 (7) |
| CX3CL1 | -3.20e-01 | cytokine | NA | -1.89e+00 | 1.0e-02 | ADAMTS1,ASPA,BCL2L11,CCND1,CD200R1L,FABP7,ID2,IFIT3,LAMC1,LMO4,MEIS2,SOX5,SPON2,TGFB1 | NA |
| LAS1L | 1.60e-01 | other | NA | -1.90e+00 | 0.0e+00 | ASS1,BTG2,CDKN1A,CEMIP,CPT1A,DUSP6,GSTT2/GSTT2B,MAP1LC3B,MCM10,SESN2 | NA |
| STAR | 4.00e-02 | transporter | NA | -1.90e+00 | 0.0e+00 | AGT,CAPN10,CPT1A,PDSS1,PIK3R1,PLIN5,RB1,SLC25A33,TP53INP1,XBP1 | 143 (7) |
| ITPR2 | 1.10e-01 | ion channel | NA | -1.90e+00 | 0.0e+00 | AFAP1L2,C5AR2,CD180,CD274,Ifi47,Igtp,Irgm1,ITPR1,SYK,TNFAIP3 | NA |
| memantine | NA | chemical drug | NA | -1.90e+00 | 4.0e-02 | ATP2B2,CACNB4,CREM,ELAVL1,EPHA4,KIF21A,PIK3R1,POR,SIRPA,STAT3 | NA |
| mir-96 | NA | microRNA | NA | -1.91e+00 | 0.0e+00 | CMPK2,CYP7A1,IFI44L,IGFBP1,OAS2,RSAD2,RTP4 | NA |
| PELP1 | 2.20e-01 | other | NA | -1.93e+00 | 0.0e+00 | ASNS,ASS1,CCND1,CDKN1A,EGF,GSTT2/GSTT2B,HSD17B2,IFI44,MAP1LC3B,PPARGC1A,PSAT1,PTK6,SESN2,TCF7L2 | 369 (13) |
| SOX9 | 2.50e-01 | transcription regulator | NA | -1.93e+00 | 1.4e-01 | ADAMTS1,CD274,CDKN1A,CREB3L2,DLL4,IHH,SOX5,TCF7L2,TGFB1 | NA |
| mir-154 | NA | microRNA | NA | -1.93e+00 | 2.0e-02 | ADAMTS1,ATF3,BCL2L11,CCND1,STAT3 | NA |
| BAK1 | 1.00e-02 | other | NA | -1.94e+00 | 0.0e+00 | BCL2L11,CDKN1A,EDEM1,IL15,Oas1b,TRIM6-TRIM34,XBP1 | 253 (14) |
| MAP2K1/2 | NA | group | NA | -1.94e+00 | 6.0e-02 | ATF3,BCL2L11,CCND1,CCND2,CYP7A1,HERPUD1,JUN | NA |
| FOXG1 | 3.00e-02 | transcription regulator | NA | -1.94e+00 | 0.0e+00 | BCL2L11,CCND2,CDKN1A,GCK,SERPINE1 | 208 (7) |
| LEF1 | -3.40e-01 | transcription regulator | NA | -1.94e+00 | 0.0e+00 | ACSBG1,ARHGEF26,CCND1,CD101,Cd24a,CD274,CD79B,CDKN1A,CSF3R,FAS,ID2,ITSN1,LAMA3,LAMC1,LRIG1,LYSMD2,NLRP3,NRCAM,NRN1,PTPRO,RASGEF1B,RNF8,RRAGD,Serpinb6b,SPECC1,TBC1D2,TGFB1,TSC22D1 | 275 (11) |
| PADI4 | 2.40e-01 | enzyme | NA | -1.94e+00 | 0.0e+00 | CDKN1A,NLRP3,OSGIN1,PYCARD,XBP1 | 203 (7) |
| amphetamine | NA | chemical drug | NA | -1.94e+00 | 9.0e-02 | ATF3,INHBA,JUN,MYOM1,PPP1R9B,RGS3,TNFAIP3 | NA |
| isotretinoin | NA | biologic drug | NA | -1.94e+00 | 6.0e-02 | CDKN1A,FASN,IFIT3,IRF1,ODC1,RARRES1,TFRC | NA |
| D-glucose | NA | chemical - endogenous mammalian | NA | -1.95e+00 | 0.0e+00 | ACO2,AGT,ALDOA,ARG1,ASNS,ASS1,ATF3,ATP2B2,BCL2L11,CBS/LOC102724560,CCND1,CCND2,CCNE1,CDKN1A,CDT1,CEBPB,CPT2,CREM,CYP7A1,DDIT4,DLL4,DYNLL1,EFHD1,FAS,FASN,GART,GCK,GDF15,GOT1,HDAC2,HERPUD1,HNF4A,INHBA,ITPR1,JUN,LAMC1,LDLR,MAFB,MAP2K6,MID1IP1,NFE2L2,NLRP3,NOX4,NR1I2,NR3C1,NR4A2,NUP98,ODC1,PFKFB3,PLK3,POPDC2,PPARD,PPARGC1A,PPP2R2B,PYCARD,RDH16,REN,RIPK3,SCUBE3,SEPHS2,SERPINE1,SLC16A4,SLC3A2,TFRC,TGFB1,TIMM17A,TK1,TOMM40,TRPV6,VCAN,XBP1 | 523 (25) |
| pravastatin | NA | chemical drug | NA | -1.95e+00 | 1.0e-02 | ADCYAP1R1,CCNE1,CYP7A1,ENC1,LDLR,PCSK9,SDC4,TGFB1 | 385 (21) |
| PDPK1 | 1.10e-01 | kinase | NA | -1.96e+00 | 4.0e-02 | CCND1,CDKN1A,FOXO1,S1PR1,SERPINE1 | NA |
| IL7 | -3.00e-01 | cytokine | NA | -1.96e+00 | 0.0e+00 | BCL2L11,CBLB,CCND2,CD274,CDKN1A,CISH,FAS,FOXO1,LYN,MAF,MAPKAPK3,MX1,PIK3IP1,S1PR1,XBP1 | 392 (22) |
| SAR1A | NA | enzyme | NA | -1.96e+00 | 0.0e+00 | CPT1A,FASN,NFE2L2,PPARGC1A | NA |
| BAX | -3.20e-01 | transporter | NA | -1.96e+00 | 0.0e+00 | BCL2L11,BIRC2,CDKN1A,EDEM1,IL15,Oas1b,TRIM6-TRIM34,XBP1 | 371 (24) |
| mir-3622 | NA | microRNA | NA | -1.96e+00 | 0.0e+00 | CCND1,CCND2,CDKN1A,GADD45B | NA |
| SOST | NA | other | NA | -1.96e+00 | 6.0e-02 | CPT1A,FASN,NOX4,PPARGC1A | NA |
| SAR1B | 4.00e-01 | enzyme | NA | -1.97e+00 | 0.0e+00 | CPT1A,FASN,NFE2L2,PPARGC1A | NA |
| miR-7a-5p (and other miRNAs w/seed GGAAGAC) | NA | mature microRNA | NA | -1.98e+00 | 4.0e-02 | MKNK1,MKNK2,SLC3A2,SYNE1 | NA |
| MYD88 | -8.00e-02 | other | NA | -1.98e+00 | 0.0e+00 | ARG1,BCL3,CCNE1,CD274,CISH,CLEC10A,CMPK2,DLL4,EDNRB,FANCB,FOXO1,GDF15,IL15,IL1RN,INHBA,IRF1,JUN,MCM10,NFKBIZ,NLRP3,NOX4,PARP2,PLA2G4A,RSAD2,SERPINE1,SH3BP2,SLC7A2,TFRC,TGFB1,TNFAIP3,TSC22D1,XBP1,ZC3H12A | 458 (20) |
| POU2AF1 | -3.40e-01 | transcription regulator | NA | -1.98e+00 | 3.0e-02 | CD79B,FOXO1,GADD45G,ID3,IFI44,IFI44L,IFIT3,MX1,SDS,STAT3,TGFB1 | NA |
| S1PR1 | -7.50e-01 | G-protein coupled receptor | NA | -1.98e+00 | 1.0e-02 | BCL2L11,CCND1,MAF,NLRP3 | NA |
| CL097 | NA | chemical reagent | NA | -1.98e+00 | 1.0e-02 | BCL3,CD274,FAS,MX1 | NA |
| DDIT4 | 8.10e-01 | other | NA | -1.98e+00 | 2.0e-02 | FASN,IL33,MAP1LC3B,NLRP3,PPARGC1A | NA |
| ammonium chloride | NA | chemical drug | NA | -1.98e+00 | 3.0e-02 | FOXO1,LDLR,NPC1,TFRC | NA |
| p70 S6k | NA | group | NA | -1.98e+00 | 4.0e-02 | BCL2L11,CCND1,FASN,NOX4 | NA |
| NCOA4 | 7.00e-01 | transcription regulator | NA | -1.98e+00 | 5.0e-02 | CLDN3,FGFR2,NR3C1,ST3GAL6 | NA |
| Hsp90 | NA | group | NA | -1.99e+00 | 1.0e+00 | CCND2,KLRD1,LYN,ZFAND2A | NA |
| BHLHA15 | -4.80e-01 | transcription regulator | Inhibited | -2.00e+00 | 0.0e+00 | ARRDC3,CXCL11,FNDC3A,NUPR1,STAT3 | NA |
| MBTPS1 | -1.00e-02 | peptidase | Inhibited | -2.00e+00 | 0.0e+00 | FASN,FDFT1,IHH,LDLR | 102 (7) |
| COMMD1 | -3.00e-01 | transporter | Inhibited | -2.00e+00 | 0.0e+00 | ALDOA,BIRC3,DDIT4,PFKFB3,TFRC | 216 (7) |
| PPP2R5C | NA | other | Inhibited | -2.00e+00 | 1.0e-02 | BCL2L11,BCL3,BIRC3,TNFAIP3 | 326 (14) |
| CYP7A1 | 9.90e-01 | enzyme | Inhibited | -2.00e+00 | 2.0e-02 | CYP7A1,FASN,FDFT1,LDLR | NA |
| IFIH1 | -2.00e-01 | enzyme | Inhibited | -2.00e+00 | 3.0e-02 | CISH,FAS,IFI44L,OAS2,RND3,RSAD2 | NA |
| trabectedin | NA | chemical drug | Inhibited | -2.00e+00 | 8.0e-02 | CCND1,CDKN1A,MX1,TK1 | NA |
| GJA1 | -1.40e-01 | transporter | Inhibited | -2.00e+00 | 1.0e-01 | CCND1,CDKN1A,FOXO1,TNFRSF11B | NA |
| miR-9-5p (and other miRNAs w/seed CUUUGGU) | NA | mature microRNA | Inhibited | -2.00e+00 | 4.1e-01 | CPT1A,CPT2,FOXO1,PFKFB3 | NA |
| CTNNB1 | 0.00e+00 | transcription regulator | Inhibited | -2.02e+00 | 0.0e+00 | ADGRG2,ARL4A,AURKA,BCL2L11,BHLHE40,CCND1,CCND2,CCNE1,CD274,CDKN1A,CHEK2,CIDEC,CLDN2,CPT1A,CPT2,CRAT,Dapk2,DLL4,EDAR,ELAVL1,ENC1,FAS,FASN,FOXA2,FZD1,GADD45B,GADD45G,GALC,GCK,GDF15,GPAT3,HHEX,HMGCS1,HNF1A,HNF4A,HSD17B2,Hsd3b4 (includes others),ID2,ID3,ID4,IHH,IL15,ITSN1,JUN,MAP1LC3B,MAP3K5,NRCAM,NRP2,PAX8,PCSK6,PIK3R1,PPARD,PPP1R13B,PPP2CA,RPS18,SERPINE1,SF3A1,SLC16A6,SLC17A9,SOX5,SRFBP1,STARD7,STAT3,SYK,TCF7L2,TELO2,TGFB1,TGM1,TNFAIP3,TNFRSF11B,TSC22D1,VCAN,WNT4 | 390 (18) |
| miR-155-5p (miRNAs w/seed UAAUGCU) | NA | mature microRNA | Inhibited | -2.02e+00 | 4.0e-02 | BACH1,BCL2L11,CCND1,CEBPB,CLDN1,MAF,MAFB,PIK3R1,PLXND1,PPL,SERPINE1,TP53INP1,WEE1 | NA |
| Ifn | NA | group | Inhibited | -2.08e+00 | 0.0e+00 | ADAMTS1,CXCL11,FAS,IL15,IL15RA,IL33,IRF1,MX1,Mx2,OAS2,RSAD2,SECTM1,SERPINE1,TFRC | 267 (18) |
| let-7 | NA | microRNA | Inhibited | -2.10e+00 | 0.0e+00 | ANKH,AURKA,BTG2,CCND1,CCNF,CCNJ,CDT1,DUSP6,EDEM1,GALE,HNF4A,ID2,IL6R,LRIG1,MAPK6,MCM10,MCM8,NOLC1,ORC1,SERPINE1,SLC1A4,STARD13,STAT3 | 281 (11) |
| NCOA3 | -1.00e-01 | transcription regulator | Inhibited | -2.10e+00 | 3.0e-02 | CCND1,CCNE1,CDKN1A,FASN,FGFR2,IGFBP1,IRF1,PPARD,XBP1 | NA |
| STEAP3 | -1.30e-01 | transporter | Inhibited | -2.11e+00 | 0.0e+00 | ACER2,Cd24a,CEBPB,HAND2,KLF15,NUPR1,P4HA1,PIK3R1,S1PR1,SH3PXD2B,TFRC | NA |
| MSB0011359C | NA | biologic drug | Inhibited | -2.11e+00 | 0.0e+00 | ATF3,BTG2,CDKN1A,CLEC10A,CMPK2,EDNRB,GADD45B,IRF1,PARP14,RGS1,RSAD2 | NA |
| Growth hormone | NA | group | Inhibited | -2.11e+00 | 0.0e+00 | AGT,CCND1,CCND2,CEBPB,CISH,CYP7A1,FASN,FKBP5,FOXA2,GDF15,IGFALS,IGFBP1,IRF1,JUN,LDLR,NOX4,ONECUT1,PFKFB3,PRKAG2,SOCS2,STC1,TGFB1,TSC22D1,UGDH | 438 (25) |
| SENP3 | 1.80e-01 | peptidase | Inhibited | -2.12e+00 | 0.0e+00 | CYTH1,H2-T22,IFI44,IFIT3,IL15,OAS2,Oasl2,RSAD2 | 293 (15) |
| Srgn | -1.00e-02 | other | Inhibited | -2.12e+00 | 0.0e+00 | BANP,CD300LF,IL21R,Irgm1,SBK1,SERPINB8,SERPINB9,STAC3 | NA |
| mir-183 | NA | microRNA | Inhibited | -2.12e+00 | 0.0e+00 | CMPK2,CYP7A1,IFI44L,IGFBP1,OAS2,PPP2CA,RSAD2,RTP4 | 154 (11) |
| IFNAR1 | -2.40e-01 | transmembrane receptor | Inhibited | -2.13e+00 | 0.0e+00 | Apol9a/Apol9b,ARG1,ASS1,ATF3,CD274,CMPK2,CXCL11,DLL1,DUSP6,HMGCS1,IFI44,IFIT3,IL15,IRF1,OAS2,Oasl2,RSAD2,RTP4,SERPINE1,SQLE,TNFAIP3,VCAN | 311 (15) |
| nickel chloride | NA | chemical toxicant | Inhibited | -2.13e+00 | 1.0e-02 | ASL,DDIT4,GCLM,JUN,MAP2K6,NFE2L2,P4HA1,PLK3 | 343 (12) |
| SASH1 | -4.10e-01 | other | Inhibited | -2.14e+00 | 0.0e+00 | CCND2,CMPK2,HELZ2,HHEX,IFIT3,IL15,IL15RA,INHBA,IRF1,LMO4,Mx2,NFKBIZ,RSAD2,TSC22D1 | 143 (7) |
| SQSTM1 | -3.20e-01 | transcription regulator | Inhibited | -2.14e+00 | 0.0e+00 | IL15,IL15RA,IRF1,JUN,MAP1LC3B,NFE2L2,RSAD2,TSC22D1,UGDH | 269 (18) |
| TLR3 | -4.40e-01 | transmembrane receptor | Inhibited | -2.14e+00 | 0.0e+00 | ATF3,CD274,CMPK2,CXCL11,FAS,GADD45B,GBP2,IFI44,IFI44L,Ifi47,IFIT3,IL15,IL1RN,IL33,IRF1,LMNB1,MBL2,MX1,NFKBIZ,Oasl2,PFKFB3,PIK3R1,RGS1,RHOB,RSAD2,SERPINB9,SERPINE1,ZNFX1 | 321 (15) |
| SOX4 | NA | transcription regulator | Inhibited | -2.18e+00 | 3.4e-01 | Acot1,EFNA5,EIF4E3,NREP,NRXN2,PLXNA2,PLXND1,PXYLP1,RARRES1,RNF144A,TDRKH | NA |
| stallimycin | NA | biologic drug | Inhibited | -2.19e+00 | 5.0e-02 | IFI44,IFIT3,INHBA,IRF1,MX1 | NA |
| TEAD4 | -9.00e-02 | transcription regulator | Inhibited | -2.19e+00 | 0.0e+00 | CCND1,CDKN1A,CIDEC,EDNRA,FGFR2,FKBP5,GPR37,IRF6,JUN,NFKBIZ,NRXN2,PTPRO,RB1 | 381 (12) |
| GABA | NA | chemical - endogenous mammalian | Inhibited | -2.20e+00 | 0.0e+00 | AMACR,AMD1,ATP1B1,ATP2B2,CACNB2,CCND2,CREB3L2,DHCR24,DLAT,DNAJA1,EGF,FASN,FOXA2,FZD1,GALC,GCLM,GMPS,GNL2,GNL3,GYS1,HERPUD1,ITPR1,MTHFD1,P4HA1,PEX6,PPP2CA,PXMP4,RPS18,SF3A1,SMAP1,ST3GAL5,TGFB1,WDR3,WNT4,YOD1 | 330 (12) |
| IFNL3 | NA | cytokine | Inhibited | -2.20e+00 | 1.0e-02 | IL15,MX1,Mx2,Oas1b,RSAD2 | 211 (11) |
| rosuvastatin | NA | chemical drug | Inhibited | -2.21e+00 | 2.0e-02 | CYP7A1,FDFT1,HMGCS1,LDLR,PCSK9 | NA |
| HOXA9 | NA | transcription regulator | Inhibited | -2.22e+00 | 2.0e-02 | BCL2L11,CISH,CREM,EDNRA,FZD1,HIGD1A,ID2,JUN,LYN,MAFB,PRKD3,RCBTB2,SDC4,SERPINB9,TSC22D1 | NA |
| ribavirin | NA | chemical drug | Inhibited | -2.24e+00 | 4.0e-02 | IFI44L,IFIT3,IRF1,MX1,RSAD2 | NA |
| 12-(3-adamantan-1-yl-ureido) dodecanoic acid | NA | chemical reagent | Inhibited | -2.24e+00 | 7.0e-02 | BCL2L11,BIRC3,DFFB,FAS,PYCARD,TNFRSF11B | NA |
| 1810019D21Rik | NA | other | Inhibited | -2.24e+00 | 1.2e-01 | ASS1,CCNG1,CDKN1A,PALMD,SYNE1 | NA |
| miR-146a-5p (and other miRNAs w/seed GAGAACU) | NA | mature microRNA | Inhibited | -2.24e+00 | 4.7e-01 | ATOH8,IL1RL2,MCM10,PLEKHA4,PRR15 | NA |
| RICTOR | 2.40e-01 | other | Inhibited | -2.24e+00 | 1.0e+00 | ATP6V1B2,BCL2L11,CLDN1,COX10,GCK,IGFBP1,OAS2,PFKFB3,RPS18,SLC25A47 | NA |
| STING1 | NA | other | Inhibited | -2.24e+00 | 1.0e-02 | ARG1,CXCL11,IFI44,IFI44L,IFIT3,IL15RA,IL33,INHBA,KLRD1,MAPK11,MX1,PLEKHA4,RSAD2,TNFRSF11B | 214 (17) |
| mir-122 | 1.80e-01 | microRNA | Inhibited | -2.28e+00 | 0.0e+00 | ALDOA,CCNG1,CYP7A1,GALNT10,GNPNAT1,GYS1,INSIG1,LAMC1,PPP2CA,PTPN1,RBM3 | 109 (7) |
| E. coli B4 lipopolysaccharide | NA | chemical toxicant | Inhibited | -2.28e+00 | 1.0e-02 | CD274,CLDN1,CYP7A1,FAS,GADD45G,GBP2,GNA14,IFIT3,Igtp,IL15,IL1RN,IL33,LILRB3,NLRP3,Oasl2,PARP9,PLA2G4A,PYCARD,RSAD2,RTP4,SARM1,TNFAIP3 | NA |
| CIDEC | 6.50e-01 | other | Inhibited | -2.30e+00 | 1.0e-02 | CPT1A,FASN,PNPLA2,PPARGC1A,PPARGC1B,SERPINE1 | 391 (17) |
| BTK | -4.70e-01 | kinase | Inhibited | -2.31e+00 | 0.0e+00 | CCND2,CCNE1,CD274,CDKN1A,CEBPB,CISH,FOXO1,IFI44L,IFIT3,IL21R,IRF1,JUN,MX1,OAS2,RB1 | 445 (24) |
| MAP2K1 | 2.00e-02 | kinase | Inhibited | -2.32e+00 | 0.0e+00 | ACSBG1,ATF3,BCL2L11,BIRC2,BIRC3,CCND1,CD274,CDKN1A,CLDN2,CYP17A1,DUSP6,ETV5,FASN,GADD45B,IRX4,ITPR1,JUN,LDLR,MOG,NET1,PLA2G4A,RRAGD,SIRPA,TGFB1,TK1,UBC,UNC5B | 444 (21) |
| FADD | -1.90e-01 | other | Inhibited | -2.33e+00 | 2.0e-02 | BIRC3,CCND2,CCNE1,CDKN1A,FAS,GADD45B,JUN,Mx2,TNFAIP3 | NA |
| L-arginine | NA | chemical - endogenous mammalian | Inhibited | -2.35e+00 | 0.0e+00 | ASL,ASS1,ELAVL1,NR1I2,SERPINE1,SLC7A2,TFRC,TGFB1 | 182 (7) |
| S100A9 | -5.50e-01 | other | Inhibited | -2.36e+00 | 0.0e+00 | ADAMTS1,ALPL,ATF3,BCL3,BHLHE40,CCND1,CD274,DDIT4,EFNA1,ETV5,FAS,IL33,KLF15,PER1,PIK3IP1,PLK3,PTPRO,VCAN | 443 (21) |
| IRS2 | 2.20e-01 | enzyme | Inhibited | -2.37e+00 | 1.0e-02 | CCND1,FASN,GCK,IGFBP1,MX1,PPARGC1A | NA |
| SB 216763 | NA | chemical drug | Inhibited | -2.38e+00 | 0.0e+00 | BHLHE40,CCND1,DLL4,FASN,FSCN1,MAF,NR4A2,RGS1,RND3 | 440 (21) |
| clozapine | NA | chemical drug | Inhibited | -2.40e+00 | 1.0e-02 | FASN,FOXA1,HDAC2,HMGCS1,LDLR,NR4A2,PPARGC1A,PPP1R9B | 387 (20) |
| STAT1 | -5.40e-01 | transcription regulator | Inhibited | -2.40e+00 | 0.0e+00 | AGT,ARG1,BCL2L11,CCND1,CCND2,CCNE1,CD274,CDKN1A,CMPK2,CREM,CSF3R,CXCL11,DUOX2,FAS,FOXO1,GBP2,GCK,IFI44,IFI44L,Ifi47,IFIT3,Igtp,IL15,IL15RA,IL33,IRF1,Irgm1,JUN,MX1,Mx2,NOX4,OAS2,Oasl2,PARP9,PPARD,PPARGC1B,RSAD2,RTP4,STAT3,TGFB1,TNFAIP3 | 359 (17) |
| PI3K (family) | NA | group | Inhibited | -2.41e+00 | 0.0e+00 | BCL2L11,BIRC3,CD274,CLDN2,CXCL11,DDIT4,FASN,FOXO1,GCLM,NFE2L2,RIPK3,SERPINE1 | 446 (23) |
| FMR1 | -8.00e-02 | translation regulator | Inhibited | -2.42e+00 | 1.0e+00 | ALDOA,ATF3,ATP2B2,CACNB4,PXMP4,RPRM,RPS18,ST3GAL6 | NA |
| N-ethyl-N-nitrosourea | NA | chemical toxicant | Inhibited | -2.43e+00 | 2.0e-02 | CDKN1A,IFI44,IFIT3,Mx2,Oas1b,OAS2,Oasl2 | NA |
| AURK | NA | group | Inhibited | -2.43e+00 | 3.0e-02 | ACER2,BTG2,CDKN1A,PHLDB3,SESN2,STOM | NA |
| IRF1 | -6.40e-01 | transcription regulator | Inhibited | -2.44e+00 | 0.0e+00 | CCND1,CD274,CDKN1A,CEBPB,CMPK2,CXCL11,FAS,GBP2,HELZ2,IFI44,IFI44L,Ifi47,IFIT3,IL15,IL33,IRF1,MX1,OAS2,ODC1,RSAD2,STAT3,TGFB1,TLR6,TMEM140 | 362 (19) |
| ANLN | -3.70e-01 | other | Inhibited | -2.45e+00 | 3.0e-02 | ACER2,BTG2,CDKN1A,PHLDB3,SESN2,STOM | NA |
| FEV | -1.80e-01 | transcription regulator | Inhibited | -2.45e+00 | 2.0e-01 | ADRA1B,EFNA5,FOXA1,NR3C1,STXBP6,TCF7L2 | NA |
| SYK | -6.00e-01 | kinase | Inhibited | -2.45e+00 | 7.0e-02 | BCL2L11,BIRC3,CCND1,CREM,IRF1,OAS2,TGFB1,TP53INP1,TSC22D1 | NA |
| IRF5 | -1.20e-01 | transcription regulator | Inhibited | -2.56e+00 | 0.0e+00 | CDKN1A,CMPK2,CXCL11,FOXO1,IFI44,IFIT3,OAS2,Oasl2,RSAD2,TGFB1,TMPO | 258 (17) |
| ZBTB10 | 9.00e-02 | transcription regulator | Inhibited | -2.57e+00 | 0.0e+00 | 9930111J21Rik1/Gm12185,BCL2L11,CD274,DTX3L,Ifi47,IFIT3,Igtp,IL15,IL1RN,IRF1,Irgm1,LGALS9B,MAP3K14,Mx2,PARP9,RTP4,SERPINE1,TNFRSF14,TRIM6-TRIM34 | 155 (7) |
| IL27 | -1.90e-01 | cytokine | Inhibited | -2.58e+00 | 2.0e-02 | CCND2,CD274,CXCL11,FAS,GADD45G,GBP2,ID2,IL15RA,IL1RN,IRF1,MAF,MX1,NR3C1 | NA |
| PRL | NA | cytokine | Inhibited | -2.58e+00 | 0.0e+00 | AKR1C4,CCND1,CDKN1A,CISH,CLDN3,CMPK2,COA7,CXCL11,DTX3L,EGF,HELZ2,HERPUD1,Hsd3b4 (includes others),ID2,ID3,IFI44,IFI44L,IFIT3,IGFALS,IRF1,JUN,LAMC1,NUPR1,OAS2,ODC1,PARP14,PDE7A,PIM3,PPM1K,RSAD2,SOCS2,STAT3,TGFB1,TMEM140,TSC22D1 | 398 (21) |
| KDM1A | -2.70e-01 | enzyme | Inhibited | -2.60e+00 | 0.0e+00 | AGT,ATF3,BCL3,CCND2,CD274,CDKN1A,CEBPB,CYP7A1,ELL2,FASN,FGR,FOXA2,FOXO1,GBP2,ID2,IFI44,IFIT3,Igtp,IL1RN,IL21R,Irgm1,LAMA3,MCM8,Mx2,MYO1B,Oasl2,PARP14,PLIN4,PSAT1,SERPINE1,SHROOM3,SIX5,SLC7A10,SOCS2,TGM1 | 499 (24) |
| TLR4 | -7.00e-01 | transmembrane receptor | Inhibited | -2.60e+00 | 0.0e+00 | ALDOA,ARG1,ATF3,CCND2,CD274,CERS6,CISH,CMPK2,DLL4,DUOX2,EFNA1,EGF,FAS,FASN,GADD45G,GBP2,HELZ2,HHEX,Ifi47,IFIT3,Igtp,IL15,IL15RA,INHBA,IRF1,Irgm1,LMO4,LYST,MX1,Mx2,NFKBIZ,NLRP12,NLRP3,NR4A2,PLA2G4A,RGS1,RSAD2,SGPL1,STAT3,TFRC,TGFB1,TNFAIP3,TSC22D1,XBP1,ZC3H12A | 383 (16) |
| IL2 | NA | cytokine | Inhibited | -2.61e+00 | 0.0e+00 | ADCY9,ALDOA,ASNS,AURKA,BHLHE40,BIRC3,CARD10,CBLB,CCND1,CCND2,CCNE1,CCNF,CCNG1,CD274,CDKN1A,CISH,CTPS1,CYTIP,DDIT4,DHCR24,DUSP6,EPHA4,FAS,FGFR2,FOXO1,GADD45B,GADD45G,GART,GBP2,GDF15,GNL3,HHEX,HMGCS1,IFRD1,IL17RB,IL1RN,INSIG1,IRF1,JUN,KLRD1,LDLR,MAF,MAP2K6,MAPKAPK3,MFSD2A,MX1,NET1,NIFK,ODC1,PDE3B,PINX1,PPP2R2B,PSAT1,RASGEF1B,RHOB,RNF157,SERPINB9,SERPINE1,SLC1A4,SLC3A2,SLC7A5,SOCS2,SOS1,SQLE,STAT3,TFRC,TGFB1,TNFAIP3,TNFRSF11B,TP53INP1,UGP2,WDR3,XBP1,ZDHHC23 | 432 (18) |
| EBI3 | -2.50e-01 | cytokine | Inhibited | -2.61e+00 | 1.0e-02 | CCND2,CD274,FAS,GADD45G,GBP2,IRF1,MX1 | NA |
| MXD1 | -5.80e-01 | transcription regulator | Inhibited | -2.61e+00 | 3.0e-02 | ACO2,CCND2,CCNG1,COX10,MARS2,NOP14,NOP56,ODC1 | NA |
| IFNA1/IFNA13 | NA | cytokine | Inhibited | -2.61e+00 | 2.0e-02 | CD274,CXCL11,IRF1,MX1,OAS2,RSAD2,UBE2D1 | NA |
| CpG ODN 1826 | NA | chemical reagent | Inhibited | -2.65e+00 | 6.0e-02 | ADRA1B,CD274,DLL4,IFIT3,OAS2,Oasl2,PARP14,RGS1 | NA |
| TMPRSS2-ERG | NA | fusion gene/product | Inhibited | -2.68e+00 | 0.0e+00 | CBX2,CEBPB,DDIT4,DHRS3,FSCN1,GDF15,ID3,IFI44,INHBA,KLF11,KLF9,LAMA3,MAPK11,MSLN,NUPR1,PLXNA2,PSAT1,RNF144B,ROR1,SUMO3 | NA |
| MEF2A | -3.60e-01 | transcription regulator | Inhibited | -2.70e+00 | 0.0e+00 | ARHGEF19,GBP2,IFI44,Ifi47,IFIT3,IL15,IRF1,JUN,MEOX2,Mx2,Oasl2,PDE7A,PPARGC1A,RSAD2,TGFB1 | 142 (7) |
| G protein alpha i | NA | group | Inhibited | -2.72e+00 | 0.0e+00 | ADAMTS1,ATF3,CD274,GBP2,IFIT3,Igtp,Irgm1,LDLR,Oasl2,RSAD2,TGM1 | 261 (15) |
| IFNA4 | NA | cytokine | Inhibited | -2.76e+00 | 0.0e+00 | CD274,CXCL11,GBP2,H2-T22,Irgm1,MX1,Mx2,RSAD2 | 216 (13) |
| NRIP1 | -6.60e-01 | transcription regulator | Inhibited | -2.79e+00 | 0.0e+00 | ACO2,CCND1,CCNE1,CDKN1A,CPT2,FASN,IDH3A,NR2C1,SLC16A10,TK1 | 448 (24) |
| SLC27A2 | -3.00e-02 | transporter | Inhibited | -2.80e+00 | 0.0e+00 | Acot1,CPT2,CRAT,FITM2,PEX11A,PEX16,PLIN5,PXMP4 | NA |
| RNY3 | NA | other | Inhibited | -2.83e+00 | 0.0e+00 | IFI44,IFI44L,IFIT3,MX1,OAS2,RSAD2,RTP4,SPATS2L | NA |
| S100A8 | -4.60e-01 | other | Inhibited | -2.85e+00 | 0.0e+00 | ADAMTS1,ALPL,ATF3,BCL3,BHLHE40,BIRC2,CCND1,CD274,DDIT4,EFNA1,ETV5,FAS,IL33,KLF15,PER1,PIK3IP1,PLK3,PTPRO,VCAN | 286 (12) |
| VCAN | -9.00e-01 | other | Inhibited | -2.87e+00 | 0.0e+00 | ASS1,CDKN1A,CEBPB,FAS,IFI44,IFI44L,IL1RN,LGALS9B,MSLN,MX1,OAS2,PARP14,SPATS2L,TCF7L2,TGFB1,VCAN,WNT4 | 384 (22) |
| NONO | -6.00e-02 | transcription regulator | Inhibited | -2.87e+00 | 0.0e+00 | ATP10A,CMPK2,CXCL11,CYP17A1,FASN,HAND2,IFI44,IFI44L,IFIT3,MX1,NUPR1,OAS2,PARP14,PARP9,PDE3B,PDE7A,RSAD2,RTP4,SECTM1 | NA |
| TERT | -9.00e-02 | enzyme | Inhibited | -2.91e+00 | 0.0e+00 | AMACR,ASNS,ATF3,CCND1,CCNE1,CDKN1A,DUSP6,IFI44,IFIT3,MX1,Mx2,NUCKS1,Oas1b,OAS2,Oasl2,RB1,STAT3,TK1,UBASH3B,XBP1 | 313 (21) |
| Ifnar | NA | group | Inhibited | -3.12e+00 | 2.0e-02 | CD274,GBP2,IFIT3,IL15,IRF1,Irgm1,Mx2,NLRP3,OAS2,RSAD2 | NA |
| poly rI:rC-RNA | NA | biologic drug | Inhibited | -3.16e+00 | 0.0e+00 | ACO2,Apol9a/Apol9b,ARG1,ATF3,BCL3,BIRC2,BIRC3,CCND2,CCNG1,CD274,CDC14A,CDKN1A,CEBPB,CHD7,CMPK2,COX10,CXCL11,CYP7A1,DDIT4,DLL1,DLL4,DTX3L,EXT1,FAS,GADD45B,GBP2,GDF15,HELZ2,IFI44,IFI44L,IFIT3,IGFBP1,Igtp,IL15,IL15RA,IL1RN,IL33,INHBA,IRF1,Irgm1,JUN,LGALS9B,LYN,MAFB,MARS2,MBL2,MOG,MX1,Mx2,NFKBIZ,NLRP3,NOP14,NOP56,NR4A2,Oas1b,OAS2,Oasl2,ODC1,PARP14,PFKFB3,PIM3,PPM1K,PPP2CA,PTK6,RGS1,RNF4,RSAD2,RTP4,SDC4,SECTM1,SERPINE1,SIRPA,SLC7A2,SPSB1,SQLE,SSBP3,SYK,TCF7L2,TGFB1,TLR6,TNFAIP3,TNFRSF11B,TRIM6-TRIM34,ZC3H12A | 381 (19) |
| CHROMR | NA | other | Inhibited | -3.22e+00 | 0.0e+00 | BCL3,CDKN1A,CXCL11,DDIT4,DTX3L,EXT1,GBP2,IFI44,IFI44L,IFIT3,IL1RN,IRF1,MAFB,MX1,OAS2,ODC1,PFKFB3,PIM3,PPM1K,RSAD2,RTP4,SECTM1,SERPINE1,SIRPA,SPSB1,SQLE,SSBP3,TCF7L2,TNFAIP3 | NA |
| IFNB1 | NA | cytokine | Inhibited | -3.23e+00 | 0.0e+00 | AGL,BHLHE40,Cd24a,CD274,CDKN1A,CMPK2,CREM,CXCL11,DLL1,GBP2,HMGCS1,Ifi47,IFIT3,Igtp,IRF1,Irgm1,MCM10,MX1,NNMT,NOCT,Oas1b,OAS2,Oasl2,PARP14,PARP9,PKP2,RND3,RSAD2,SQLE,TRIM6-TRIM34 | 300 (14) |
| IFNL1 | NA | cytokine | Inhibited | -3.23e+00 | 0.0e+00 | ATF3,CMPK2,CXCL11,IFI44,IFI44L,IFIT3,MX1,OAS2,RSAD2,RTP4,TMEM140 | 349 (18) |
| IFNA2 | NA | cytokine | Inhibited | -3.61e+00 | 0.0e+00 | CD274,CDKN1A,CISH,CMPK2,CXCL11,FAS,GBP2,GOT1,HMGCS1,IFI44,IFI44L,IFIT3,IRF1,LPAR6,LYN,MX1,Mx2,OAS2,PARP9,RB1,RSAD2,SERPINB9,SOCS2,XBP1 | 234 (16) |
| pyridostatin | NA | chemical reagent | Inhibited | -3.71e+00 | 0.0e+00 | CMPK2,CXCL11,HELZ2,IFI44,IFI44L,IFIT3,IL15,IRF1,MX1,PARP14,PARP9,RSAD2,RTP4,TMEM140 | 274 (13) |
| IRF7 | -5.10e-01 | transcription regulator | Inhibited | -4.23e+00 | 0.0e+00 | CMPK2,DNAJA1,FZD1,HELZ2,IFI44,IFI44L,Ifi47,IFIT3,Igtp,IL15,IL15RA,IL33,IRF1,Irgm1,MX1,Mx2,OAS2,Oasl2,PARP14,RSAD2,RTP4,TMPO | 200 (15) |
| IRF3 | -6.00e-02 | transcription regulator | Inhibited | -4.24e+00 | 0.0e+00 | BIRC2,BIRC3,CD274,CMPK2,FAS,HELZ2,IFI44,IFI44L,Ifi47,IFIT3,Igtp,IL15,IL33,IRF1,Irgm1,Mx2,NR3C1,OAS2,Oasl2,PAH,PARP14,RSAD2,TMPO,TNFAIP3 | 166 (14) |
| RNA polymerase II | NA | complex | NA | NA | 0.0e+00 | ALPL,ARG1,ASNS,AURKA,CA12,CCND2,CDKN1A,CHEK2,CISH,CLDN3,CYP7A1,GADD45B,GBP2,GDF15,GOT1,HDAC2,HNF1A,HNF4A,Ifi47,IGFBP1,IL1RN,JUN,KPNA2,KSR2,LDLR,OSGIN1,PPARGC1B,RND3,RPRM,TGFB1,TRPV6,UBC | 343 (12) |
| INPP5F | -6.00e-02 | phosphatase | NA | NA | 0.0e+00 | CCND2,CCNE1,INHBA,MEIS2,NR3C1,PLK3,PPME1,PTP4A1,RCBTB1 | NA |
| PRKAG3 | 2.90e-01 | kinase | NA | NA | 0.0e+00 | AMD1,ATP1B1,BTG2,CIDEC,DLAT,ELL2,GADD45G,GOT1,IL15,MAP2K6,MID1IP1,MTERF2,NR3C1,NRIP1,ODC1,PDE7A,PPARGC1A,RAMP1,SLC7A2,TFRC,UGP2,WNT4 | NA |
| HNRNPA2B1 | 1.80e-01 | other | NA | NA | 0.0e+00 | ADGRG2,CA12,CACNB2,CEMIP,CIDEC,CLDN1,EDAR,FSCN1,GDF15,MEIS2,NRCAM,P4HA1,PCSK9,PPARGC1A,ROR1,SETBP1,STOM,UBASH3B,VCAN,WNT4 | NA |
| GPD1 | 3.90e-01 | enzyme | NA | NA | 0.0e+00 | Acnat1/Acnat2,ALPL,Aox3,ASNS,C11orf86,CCND1,CGREF1,FMO3,GPAT3,Hsd3b4 (includes others),PFKFB3,PSAT1,RARRES1,SERPINA7 | NA |
| GNA14 | -7.90e-01 | enzyme | NA | NA | 0.0e+00 | ADAMTS1,ARG1,ATF3,BTG2,CREM,GALE,GBP2,IL1RN,MEOX2,NR4A2,SELENBP1,ZFP36L1 | 204 (7) |
| PSMD14 | 2.30e-01 | peptidase | NA | NA | 0.0e+00 | BCL2L11,BCL3,CCND1 | 383 (15) |
| OLA1 | 1.40e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,CCNE1,CDKN1A | 242 (7) |
| SLC25A13 | NA | transporter | NA | NA | 0.0e+00 | Acnat1/Acnat2,ALPL,Aox3,ASNS,C11orf86,CCND1,CGREF1,FMO3,GPAT3,Hsd3b4 (includes others),PFKFB3,PSAT1,RARRES1,SERPINA7 | NA |
| pituitary adenylate cyclase-activating polypeptide | NA | biologic drug | NA | NA | 0.0e+00 | ACER2,ADGRL2,AGL,CCND1,CCND2,DUSP6,EPHA4,STOM,WNT4 | NA |
| PRDM5 | -7.00e-02 | transcription regulator | NA | NA | 0.0e+00 | ACSBG1,CEMIP,EDNRA,GADD45B,GCK,ID2,IL6R,INTS3,ISLR,NREP,POU2F3,SNRNP48,TINAGL1 | NA |
| EIF2S1 | 3.80e-01 | translation regulator | NA | NA | 0.0e+00 | CCND1,CCNE1,CEBPB,IFRD1,MAP1LC3B,NNMT,NUPR1,PLIN4,SESN2,TGM1 | NA |
| RBCK1 | -3.00e-02 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CXCL11,FOXO1,IFIT3,IL33,IRF1,MAP2K6,TNFAIP3 | 385 (14) |
| IRAK4 | -2.00e-01 | kinase | NA | NA | 0.0e+00 | ATF3,BIRC3,BTG2,IFRD1,IRF1,JUN,NFKBIZ,NLRP3,NOCT,SLC25A25,TNFAIP3,ZC3H12A | 288 (14) |
| TAF6 | -2.00e-01 | transcription regulator | NA | NA | 0.0e+00 | ATF3,C11orf24,CDKN1A,IRF1,JUN,PRDM10,SRSF4 | 204 (7) |
| mechlorethamine | NA | chemical drug | NA | NA | 0.0e+00 | ATF3,DUOX2,ID2,NFE2L2 | NA |
| ADRA1D | 2.90e-01 | G-protein coupled receptor | NA | NA | 0.0e+00 | ADRA1B,CCNE1,CEBPB,CREM,JUN,NR4A2,POLA1,STAT3,TMPO | 259 (10) |
| L-alanine | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CCND1,CCNE1,CDKN1A | NA |
| CINP | -1.10e-01 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A,RB1 | NA |
| AHNAK | -2.20e-01 | other | NA | NA | 0.0e+00 | CCND1,CCND2,CDKN1A | 413 (19) |
| ELOA | 3.10e-01 | transcription regulator | NA | NA | 0.0e+00 | ATF3,CCNE1,CDKN1A | 8 (2) |
| COL1A2 | NA | other | NA | NA | 0.0e+00 | CDKN1A,SERPINE1,TGFB1 | 143 (7) |
| MPZ | -2.20e-01 | other | NA | NA | 0.0e+00 | FDFT1,HMGCS1,ID2,JUN,SQLE,XBP1 | NA |
| epicatechin gallate | NA | chemical drug | NA | NA | 0.0e+00 | ARG1,CCNG1,CDKN1A,GDF15,LYN,RPRM | 388 (19) |
| GNA15 | -9.00e-01 | enzyme | NA | NA | 0.0e+00 | ARG1,GBP2,IL1RN,MAFK,NOX4,ODC1,Omd,PAWR,SELENBP1,SYNE1,UGDH,UNC5B,VCAN,ZFP36L1 | 248 (12) |
| KIT | -5.00e-02 | transmembrane receptor | NA | NA | 0.0e+00 | ANKH,BCL2L11,CCND2,CD274,CISH,Ifi47,IFIT3,Igtp,IL15,IL15RA,IRF1,SH3BP2,SOCS2,STAT3 | 357 (19) |
| diphtheria toxin | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | BCL3,Cd24a,CD274,DBT,DCLRE1B,DUSP6,EGF,HHEX,IL1RL2,NLRP3,PFKFB3,PIK3R1,PTPN1,Tlr12,TNFAIP3,ZMYND15 | NA |
| BCO2 | NA | enzyme | NA | NA | 0.0e+00 | ARRDC3,DLAT,SLC25A30,SPON2 | NA |
| Histone h3 | NA | group | NA | NA | 0.0e+00 | ADRA1B,ATF3,BCL2L11,CCND1,CCND2,CCNE1,CDKN1A,EFNA1,FASN,FGFR2,FKBP5,FOXA1,FOXA2,HNF4A,ID2,IL6R,JUN,MAF,MEIS2,MX1,NHLRC1,OSGIN1,PALLD,PER1,PIK3R1,POU2F3,PPARGC1A,PPP2R2B,RB1,RPRM,RSAD2,SHANK3,SLC16A6,SPATS2L,STOM,TGFB1,TNFAIP3,UBC,XBP1 | 441 (23) |
| TCF | NA | group | NA | NA | 0.0e+00 | ADGRG2,ARL4A,CCND1,CRAT,HSD17B2,ID3,IHH,NRCAM,PCSK6,SERPINE1,TK1,TSC22D1 | 195 (7) |
| L-aspartic acid | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CCND1,CCNE1,CDKN1A | NA |
| Cathepsin | NA | group | NA | NA | 0.0e+00 | CCND1,CCND2,CCNE1 | 220 (12) |
| AZD1480 | NA | chemical drug | NA | NA | 0.0e+00 | CBLB,SLC3A2,SLC7A5 | NA |
| CHKA | -1.51e+00 | kinase | NA | NA | 0.0e+00 | CD274,CHKA,TGFB1 | NA |
| PSAP | 9.00e-02 | other | NA | NA | 0.0e+00 | BIRC2,BIRC3,CCND1 | 324 (11) |
| silicon phthalocyanine | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CCNE1,CDKN1A | 404 (21) |
| TAF4B | 5.40e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND2,INHBA,IRF1,JUN,TGFB1,TNFAIP3 | NA |
| PBX1 | -1.00e-01 | transcription regulator | NA | NA | 0.0e+00 | AMD1,CDKN1A,FABP7,GCK,REN,STAT3,TCF7L2 | NA |
| Fcor | NA | enzyme | NA | NA | 0.0e+00 | BCL2L11,CDKN1A,PPARGC1A,RB1 | 178 (7) |
| KLF7 | NA | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,IFIT3,IL1RN,MX1 | NA |
| FGFR4 | -2.80e-01 | kinase | NA | NA | 0.0e+00 | CCND1,CDKN1A,CYP7A1,FASN,NRIP1,SERPINE1,TGFB1 | 296 (19) |
| GNB2 | 2.00e-02 | enzyme | NA | NA | 0.0e+00 | CDKN1A,CREM,CYTH1,CYTIP,FBXO31,MAFB,NR4A2 | NA |
| thymidine | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CCND1,CDKN1A,FAS,TK1 | 319 (17) |
| STAT2 | 4.20e-01 | transcription regulator | NA | NA | 0.0e+00 | Ifi47,IFIT3,IRF1,MX1,OAS2,Oasl2,RSAD2,RTP4,SF3A1 | 257 (14) |
| GNB1 | 2.90e-01 | enzyme | NA | NA | 0.0e+00 | CDKN1A,CREM,CYTH1,CYTIP,FBXO31,MAFB,NR4A2 | 157 (6) |
| IAPP | 3.00e-02 | other | NA | NA | 0.0e+00 | FDFT1,HMGCS1,MSMO1,STAT3,TK1 | 197 (7) |
| OSU-2S | NA | chemical reagent | NA | NA | 0.0e+00 | CCNE1,CDKN1A,CEBPB | NA |
| CYP3A | NA | group | NA | NA | 0.0e+00 | CYP7A1,HMGCS1,SQLE | 112 (9) |
| Ins1 | NA | other | NA | NA | 0.0e+00 | IGFBP1,TAT,TK1 | 279 (7) |
| H6PD | 5.40e-01 | enzyme | NA | NA | 0.0e+00 | GCK,MAP1LC3B,TAT | NA |
| PLSCR1 | 1.90e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,CDKN1A,ITPR1 | 166 (7) |
| mir-637 | NA | microRNA | NA | NA | 0.0e+00 | CCND1,FOXO1,NUPR1 | NA |
| DYNLL1 | -7.00e-01 | other | NA | NA | 0.0e+00 | BCL2L11,CCNE1,CDKN1A | 407 (18) |
| ASGR1 | -1.60e-01 | transmembrane receptor | NA | NA | 0.0e+00 | INSIG1,LDLR,PCSK9 | 132 (5) |
| TFF2 | NA | other | NA | NA | 0.0e+00 | CCND1,CCND2,CCNE1 | 363 (18) |
| adiporon | NA | chemical reagent | NA | NA | 0.0e+00 | CEBPB,PNPLA2,PPARGC1A | NA |
| L-asparagine | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CCND1,CCNE1,CDKN1A | 352 (12) |
| ritonavir | NA | chemical drug | NA | NA | 0.0e+00 | ARHGEF19,C12orf42,C9orf72,CCND2,CCNJ,ELAVL1,FDFT1,GBP2,IFRD1,LAMA3,LDLR,MRPL47,MSMO1,SQLE,TMEM140 | 57 (6) |
| ZBTB49 | 2.60e-01 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,RB1 | NA |
| ACER3 | -1.00e-02 | enzyme | NA | NA | 0.0e+00 | ACER2,CDKN1A | NA |
| ZNF224 | NA | transcription regulator | NA | NA | 0.0e+00 | ALDOA,TNFAIP3 | NA |
| Hnrpfl | NA | other | NA | NA | 0.0e+00 | AGT,ELL2 | NA |
| CRTAP | NA | other | NA | NA | 0.0e+00 | CDKN1A,SERPINE1 | NA |
| ZFYVE16 | -2.00e-02 | other | NA | NA | 0.0e+00 | CDKN1A,SERPINE1 | 207 (7) |
| fidarestat | NA | chemical drug | NA | NA | 0.0e+00 | NLRP3,PYCARD | NA |
| oxazepam | NA | chemical drug | NA | NA | 0.0e+00 | GADD45B,TSC22D1 | NA |
| 1-o-hexadecyl-2-o-methyl-rac-glycerol | NA | chemical - kinase inhibitor | NA | NA | 0.0e+00 | CDKN1A,RB1 | 226 (7) |
| chalcone-24 | NA | chemical reagent | NA | NA | 0.0e+00 | BIRC2,BIRC3 | NA |
| AGN 190299 | NA | chemical drug | NA | NA | 0.0e+00 | EGF,TGM1 | NA |
| tibolone | NA | chemical drug | NA | NA | 0.0e+00 | PFKFB3,SERPINE1 | NA |
| BCO1 | -3.40e-01 | enzyme | NA | NA | 0.0e+00 | ARRDC3,DLAT,SLC25A30,SPON2 | NA |
| ADRA1A | -9.00e-02 | G-protein coupled receptor | NA | NA | 0.0e+00 | CCNE1,CEBPB,CREM,JUN,NR4A2,POLA1,STAT3,TMPO | 389 (19) |
| DNASE2 | -2.40e-01 | enzyme | NA | NA | 0.0e+00 | ACKR4,Apol9a/Apol9b,IFIT3,Oasl2,RSAD2,RTP4 | NA |
| BSCL2 | 2.30e-01 | other | NA | NA | 0.0e+00 | CCND1,CIDEC,CLEC10A,GCK,IL33,LPIN1,PNPLA2,PPARGC1B,RSAD2 | 161 (7) |
| chloropromazine | NA | chemical drug | NA | NA | 0.0e+00 | FDFT1,HMGCS1,LDLR,MSMO1,NR4A2,SQLE,TMEM140 | NA |
| mezerein | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | CDKN1A,INSIG1,MX1,OAS2,SLC16A6 | 265 (7) |
| SMYD1 | 1.60e-01 | transcription regulator | NA | NA | 0.0e+00 | ACO2,AGL,FAHD1,HAND2,IDH3A,PPARGC1A,UBC,UGP2 | NA |
| rh-endostatin | NA | chemical drug | NA | NA | 0.0e+00 | FAS,JUN,MAP1LC3B | NA |
| PRMT7 | 1.80e-01 | enzyme | NA | NA | 0.0e+00 | CDKN1A,FAS,GADD45B | NA |
| PDE3A | 3.00e-02 | enzyme | NA | NA | 0.0e+00 | CCND1,CDKN1A,CREM | 372 (22) |
| CCND2 | -1.02e+00 | other | NA | NA | 0.0e+00 | CCND1,CCND2,CCNE1 | 348 (16) |
| ITGB1BP1 | -1.20e-01 | other | NA | NA | 0.0e+00 | CDKN1A,DLL1,DLL4 | 339 (12) |
| infigratinib | NA | chemical drug | NA | NA | 0.0e+00 | ALPL,CD274,TNFRSF11B | NA |
| PLAC8 | NA | other | NA | NA | 0.0e+00 | CCND1,CDKN1A,RB1 | 306 (11) |
| MAFA | 1.00e-02 | transcription regulator | NA | NA | 0.0e+00 | CA1,CDKN1A,CLCF1,EDAR,FOXO1,GNA14,GNA15,ID2,IL17RB,LAMC1,PTGER3,SERPINE1,STK33,UNC5CL,ZNF189 | NA |
| NFIC | -2.20e-01 | transcription regulator | NA | NA | 0.0e+00 | ALDOA,CCND1,CDKN1A,CYP17A1,FABP7,TGFB1 | 197 (7) |
| halofuginone | NA | chemical drug | NA | NA | 0.0e+00 | AACS,BHLHE40,Cd24a,EDNRB,GOT1,IGFBP1,IL33,LIN7A,NFE2L2,PAX8,PCSK6,POR,TGFB1,Tsc22d3,USP2 | 214 (7) |
| PLK1 | 5.80e-01 | kinase | NA | NA | 0.0e+00 | BCL2L11,CDKN1A,DTX3L,ELAVL1,PARP9,PIK3R1,PYCARD,TGFB1 | 395 (21) |
| KCNE3 | -2.10e-01 | ion channel | NA | NA | 0.0e+00 | CHKA,CISH,DUSP6,NR4A2,OSGIN1,PER1,PLK3,RDH16,TMEM120B | NA |
| PAX3 | NA | transcription regulator | NA | NA | 0.0e+00 | ASNS,ASS1,CCNE1,CDKN1A,FABP7,ID2,ID3,ID4,IL6R,MCC,MKNK1,NNMT,PRMT2,PTGER3,PTP4A1,RHOB,TSC22D1,VCAN | 275 (7) |
| SP2 | 3.10e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A,PCYT1A,SERPINE1 | NA |
| ROR2 | -4.20e-01 | kinase | NA | NA | 0.0e+00 | AURKA,CCND1,CCND2,CCNE1,CDKN1A,CHEK2,MAP1LC3B,RB1,SLC17A9,SRFBP1,WEE1 | 415 (24) |
| HBB | 1.00e-02 | transporter | NA | NA | 0.0e+00 | GDF15,IFI44,IFIT3,IL15,IL1RN,NR3C1,OAS2,PLA2G4A,SERPINE1,TGFB1,TNFAIP3 | 334 (14) |
| IFNLR1 | 1.20e-01 | transmembrane receptor | NA | NA | 0.0e+00 | ATF3,CMPK2,IFI44,IFIT3,MX1,RSAD2,TNFAIP3 | 210 (12) |
| L-proline | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CCND1,CCNE1,CDKN1A | 343 (18) |
| C4BP | NA | complex | NA | NA | 0.0e+00 | FDFT1,HMGCS1,MSMO1 | NA |
| Lefty | NA | group | NA | NA | 0.0e+00 | CDKN1A,FOXO1,IGFBP1 | NA |
| evofosfamide | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,CCND2,CDKN1A | NA |
| BANP | -1.59e+00 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A,STAT3 | 390 (21) |
| nimbolide | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | BIRC2,BIRC3,CCND1 | 307 (13) |
| MTBP | 5.40e-01 | other | NA | NA | 0.0e+00 | CCND2,CDKN1A,ODC1 | 267 (7) |
| FALEC | NA | other | NA | NA | 0.0e+00 | BTG2,CDKN1A,FAS | 242 (7) |
| BLM | 1.20e-01 | enzyme | NA | NA | 0.0e+00 | CDKN1A,IFI44L,MX1 | 267 (7) |
| SNW1 | 2.30e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A,SERPINE1 | 355 (13) |
| TNRC6A | -9.00e-02 | other | NA | NA | 0.0e+00 | BCL2L11,CDKN1A,RB1 | 294 (10) |
| Duxbl1 | NA | transcription regulator | NA | NA | 0.0e+00 | Oas1b,OAS2,Oasl2 | NA |
| DIABLO | NA | other | NA | NA | 0.0e+00 | BIRC2,BIRC3,CDKN1A | 322 (15) |
| LY-3009120 | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,DUSP6,ETV5 | 414 (18) |
| ETV6-NTRK3 | NA | fusion gene/product | NA | NA | 0.0e+00 | IFIT3,Igtp,Oasl2 | 99 (7) |
| UBE3A | 0.00e+00 | enzyme | NA | NA | 0.0e+00 | CDKN1A,NR4A2,SERPINE1,TP53INP1,WNT4 | 349 (13) |
| spermidine | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | AMD1,CDKN1A,ODC1,XBP1 | 318 (13) |
| ADRA1B | -8.80e-01 | G-protein coupled receptor | NA | NA | 1.0e-02 | CCND1,CDKN1A,CEBPB,CREM,JUN,NR4A2,TMPO | 371 (21) |
| nafenopin | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CPT1A,CYP17A1,IGFBP1,POR,PTP4A1 | 239 (12) |
| GY1-22 | NA | chemical reagent | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| L-ornithine | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CDKN1A,PNPLA2 | NA |
| tolylfluanid | NA | chemical toxicant | NA | NA | 1.0e-02 | FASN,LPIN1 | NA |
| natriuretic peptide derivative | NA | biologic drug | NA | NA | 1.0e-02 | PPARD,PPARGC1A | 196 (7) |
| ZNF451 | 3.20e-01 | enzyme | NA | NA | 1.0e-02 | CDKN1A,SERPINE1 | NA |
| avexitide | NA | biologic drug | NA | NA | 1.0e-02 | AGT,NOX4 | NA |
| KLHL2 | -1.80e-01 | other | NA | NA | 1.0e-02 | CCND1,JUN | 145 (7) |
| TCF4-CTNNβ | NA | complex | NA | NA | 1.0e-02 | ID2,ID4 | NA |
| CSNK1E | 4.00e-01 | kinase | NA | NA | 1.0e-02 | PER1,SERPINE1 | NA |
| GPC3 | -8.00e-02 | other | NA | NA | 1.0e-02 | CCND1,LDLR | NA |
| PSMC5 | 3.70e-01 | transcription regulator | NA | NA | 1.0e-02 | CCND2,LYN | NA |
| AGAP2 | 3.10e-01 | enzyme | NA | NA | 1.0e-02 | CCND1,UNC5B | 244 (7) |
| MCRS1 | 1.80e-01 | other | NA | NA | 1.0e-02 | CDKN1A,RB1 | 211 (7) |
| U2AF2 | 4.00e-02 | other | NA | NA | 1.0e-02 | CCND1,CDKN1A | 226 (7) |
| STRAP | 2.80e-01 | other | NA | NA | 1.0e-02 | JUN,SERPINE1 | NA |
| DLST | 3.80e-01 | enzyme | NA | NA | 1.0e-02 | JUN,PIK3R1 | NA |
| PGD | NA | enzyme | NA | NA | 1.0e-02 | SLC3A2,TFRC | NA |
| SYF2 | 1.40e-01 | other | NA | NA | 1.0e-02 | CDKN1A,POLA1 | NA |
| MXD4 | NA | transcription regulator | NA | NA | 1.0e-02 | ID2,ODC1 | NA |
| PAGR1 | NA | other | NA | NA | 1.0e-02 | CEBPB,NR3C1 | 317 (12) |
| RASSF7 | -2.40e-01 | other | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| SLC14A2 | 0.00e+00 | transporter | NA | NA | 1.0e-02 | REN,TGFB1 | NA |
| silvestrol | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | CD274,JUN | NA |
| HES6 | -4.60e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,HNF4A | NA |
| POLG2 | 1.42e+00 | enzyme | NA | NA | 1.0e-02 | IFIT3,RSAD2 | NA |
| MXD3 | NA | transcription regulator | NA | NA | 1.0e-02 | ID2,ODC1 | NA |
| SRSF5 | NA | other | NA | NA | 1.0e-02 | AZIN1,NR3C1 | NA |
| RDH16 | 8.70e-01 | enzyme | NA | NA | 1.0e-02 | CCND1,CYP26A1 | NA |
| HNRNPF | 2.00e-02 | other | NA | NA | 1.0e-02 | LPIN1,NFE2L2 | NA |
| CDK4 | -1.60e-01 | kinase | NA | NA | 1.0e-02 | AURKA,BCL2L11,BRWD1,CDKN1A,ELAVL1,MORC4,PAH,POLD3,PPCS,STOM,TBCK,THNSL1,TOR3A,TP53INP1 | 339 (17) |
| sphingosylphosphocholine | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | DUSP6,JUN,TGM1 | 263 (10) |
| ST-4 SEC2 mutant superantigen | NA | chemical reagent | NA | NA | 1.0e-02 | FASN,INSIG1,LDLR | 356 (17) |
| 11-dehydrocorticosterone | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | FASN,PNPLA2,PPARGC1A | 279 (12) |
| Hoxa11os | NA | other | NA | NA | 1.0e-02 | NLRP3,PYCARD,STAT3 | NA |
| TENM1 | NA | transmembrane receptor | NA | NA | 1.0e-02 | EDNRB,SLC1A4,SOX5 | NA |
| SMAD1/5 | NA | group | NA | NA | 1.0e-02 | CEBPB,ID2,ID3 | NA |
| ZFP36L2 | 4.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CD274,DDIT4,SESN2 | NA |
| MED15 | 1.00e-01 | transcription regulator | NA | NA | 1.0e-02 | CCND1,CDKN1A,LIMA1 | 192 (7) |
| genipin | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | CCND1,CCNE1,CDKN1A | 311 (12) |
| YBX3 | 6.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CCND1,CLDN2,JUN | NA |
| 1,1-bis(3’-indolyl)-1-(4-trifluoromethyl-phenyl)methane | NA | chemical reagent | NA | NA | 1.0e-02 | ATF3,CDKN1A,GDF15 | 378 (18) |
| L744832 | NA | chemical reagent | NA | NA | 1.0e-02 | CDKN1A,PLD1,RHOB | 376 (16) |
| thyroid hormone receptor | NA | group | NA | NA | 1.0e-02 | CPT1A,CYP7A1,KLF9,POR,TK1 | 311 (16) |
| LDLR | -6.60e-01 | transporter | NA | NA | 1.0e-02 | AURKA,CCND1,CD274,CDKN1A,CYP7A1,CYTH1,CYTIP,DLAT,FASN,GADD45G,IL1RN,LDLR,MID1IP1,PCSK9,PPARGC1A,PRKAA1,RGS1,Serpinb6b,UBC,VCAN | 389 (23) |
| voltage-gated calcium channel | NA | complex | NA | NA | 1.0e-02 | CCND2,ITPR1,NR4A2 | 183 (7) |
| Arntl-Clock | NA | complex | NA | NA | 1.0e-02 | DBP,PER1,PER2 | 42 (3) |
| DBH-AS1 | NA | other | NA | NA | 1.0e-02 | CCND1,CCNE1,CDKN1A | 341 (21) |
| AZD4547 | NA | chemical drug | NA | NA | 1.0e-02 | CD274,CHEK2,TGFB1 | 207 (7) |
| dabrafenib | NA | chemical drug | NA | NA | 1.0e-02 | NLRP3,PYCARD,TGFB1 | 230 (7) |
| GFPT1 | -1.80e-01 | enzyme | NA | NA | 1.0e-02 | GCK,TGFB1,TK1 | 304 (13) |
| miR-138-5p (miRNAs w/seed GCUGGUG) | NA | mature microRNA | NA | NA | 1.0e-02 | SLC45A3,TGFB1,VCAN | NA |
| LUM | 8.00e-02 | other | NA | NA | 1.0e-02 | CDKN1A,FAS,TGFB1 | NA |
| Igkv1-117 | NA | other | NA | NA | 1.0e-02 | CCND2,CDKN1A,JUN | 413 (25) |
| COPS8 | -2.00e-01 | other | NA | NA | 1.0e-02 | CCND2,CCNE1,CDKN1A | NA |
| ADAM9 | 1.50e-01 | peptidase | NA | NA | 1.0e-02 | DDIT4,SLC1A4,TGFB1 | 230 (7) |
| H3C14 | -6.00e-02 | other | NA | NA | 1.0e-02 | LRP2,LSM2,RND3 | NA |
| Hmga2 | NA | enzyme | NA | NA | 1.0e-02 | HNF4A,IL15,IL15RA | NA |
| PRKCH | 5.00e-02 | kinase | NA | NA | 1.0e-02 | CCND1,CDKN1A,TGM1 | 411 (25) |
| cortistatin A | NA | chemical reagent | NA | NA | 1.0e-02 | BHLHE40,ETV6,IRF1 | NA |
| AI-1 | NA | chemical reagent | NA | NA | 1.0e-02 | GCLM,GOT1,NFE2L2 | NA |
| phenethyl isothiocyanate | NA | chemical drug | NA | NA | 1.0e-02 | BCL2L11,CCND1,EEF2K,FTSJ3,GCLM,GSTT2/GSTT2B,IFIT3,MAPK6,NNMT,PCSK9,Srrm1 | 205 (7) |
| PRKDC | -1.40e-01 | kinase | NA | NA | 1.0e-02 | BIRC3,CCND1,CDKN1A,FASN,PIM3 | 427 (21) |
| KLF9 | 6.40e-01 | transcription regulator | NA | NA | 1.0e-02 | CCND1,CYP7A1,IGFBP1,TGFB1 | 406 (17) |
| MXI1 | -5.80e-01 | transcription regulator | NA | NA | 1.0e-02 | APEX1,ID2,ODC1,SLC1A4 | NA |
| DBP | -1.04e+00 | transcription regulator | NA | NA | 1.0e-02 | AGT,CYP26A1,CYP7A1,PER1 | NA |
| POU2F1 | 2.50e-01 | transcription regulator | NA | NA | 1.0e-02 | APEX1,CCND1,CCNG1,CD79B,COX10,DDIT4,GBP2,GCLM,GSTM4,SESN2,TNFAIP3,TNFRSF14 | 386 (12) |
| IRF2BP1 | -6.00e-02 | transcription regulator | NA | NA | 1.0e-02 | ADAMTS1,ATF3,INHBA,SEC24D,TNFAIP3,TNFRSF11B | NA |
| LPIN1 | 1.66e+00 | phosphatase | NA | NA | 1.0e-02 | CDKN1A,CPT1A,FASN,LPIN1,PPARGC1A | NA |
| olaparib | NA | chemical drug | NA | NA | 1.0e-02 | BTG2,CCND1,CDKN1A,FAS,PARP2 | NA |
| GCK | -1.30e+00 | kinase | NA | NA | 1.0e-02 | CCND2,CPT1A,CPT2,FASN,TAT | NA |
| VCP | 9.00e-02 | enzyme | NA | NA | 1.0e-02 | CDKN1A,HERPUD1,LMNB1,SYNE1,TMPO | NA |
| TERC | NA | other | NA | NA | 1.0e-02 | AURKA,CDKN1A,MCM10,NUPR1,TGFB1,UPP2 | NA |
| mitoxantrone | NA | chemical drug | NA | NA | 1.0e-02 | BCL2L11,CDKN1A,FAS,Mx2,OAS2,RSAD2 | NA |
| NAB2 | 4.30e-01 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,ID2,ID4,TGFB1 | NA |
| FXN | 8.00e-02 | kinase | NA | NA | 1.0e-02 | ACO2,ATP1B1,DLAT | NA |
| PARP14 | -1.32e+00 | enzyme | NA | NA | 1.0e-02 | CCND1,ID3,Mx2 | NA |
| MBOAT7 | -1.20e-01 | enzyme | NA | NA | 1.0e-02 | DHCR24,FASN,HMGCS1 | NA |
| LAMTOR1 | -7.00e-02 | other | NA | NA | 1.0e-02 | FASN,MTHFD1,SQLE | NA |
| Ctcflos | NA | other | NA | NA | 1.0e-02 | CEBPB,PPARGC1A,THRB | NA |
| WNT5B | 4.00e-02 | other | NA | NA | 1.0e-02 | CCND1,SLC7A5,VCAN | NA |
| GADD45B | 1.58e+00 | other | NA | NA | 1.0e-02 | BIRC2,CDKN1A,TGFB1 | NA |
| ST3-Hel2A-2 | NA | chemical reagent | NA | NA | 1.0e-02 | ATF3,HERPUD1,NR4A2 | NA |
| TBC1D1 | 4.90e-01 | other | NA | NA | 1.0e-02 | CIDEC,PLIN4,PLIN5 | NA |
| KLB | -8.00e-02 | enzyme | NA | NA | 1.0e-02 | CCND1,CYP7A1,HMGCS1 | NA |
| CNB-001 | NA | chemical reagent | NA | NA | 1.0e-02 | ASNS,ATF3,HERPUD1 | NA |
| Ncoa6 | NA | transcription regulator | NA | NA | 1.0e-02 | CYP7A1,FASN,SERPINE1 | NA |
| clioquinol | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CDKN1A,JUN | NA |
| zeaxanthin | NA | chemical drug | NA | NA | 1.0e-02 | DLAT,SLC25A30,SPON2 | NA |
| hesperetin | NA | chemical drug | NA | NA | 1.0e-02 | DHCR24,LDLR,PPARGC1A | NA |
| desmosterol | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | ARG1,DHCR24,LDLR | NA |
| 4beta-hydroxycholesterol | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | FASN,LPIN1 | NA |
| Ro 25-6760 | NA | chemical toxicant | NA | NA | 1.0e-02 | CCNE1,CDKN1A | NA |
| inecalcitol | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| PH755 | NA | chemical reagent | NA | NA | 1.0e-02 | ASNS,PSAT1 | NA |
| NU-7026 | NA | chemical drug | NA | NA | 1.0e-02 | FKBP5,GDF15 | NA |
| tozasertib | NA | chemical drug | NA | NA | 1.0e-02 | AURKA,CDKN1A | NA |
| Snhg6 | NA | other | NA | NA | 1.0e-02 | CCND1,CCNE1 | NA |
| DIRAS2 | -2.00e-02 | enzyme | NA | NA | 1.0e-02 | CCND1,RB1 | NA |
| DNAJB4 | 3.90e-01 | other | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| PLEKHO2 | 2.20e-01 | other | NA | NA | 1.0e-02 | BIRC2,BIRC3 | NA |
| MUCL1 | NA | other | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| asparagine | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | ASNS,ODC1 | NA |
| pertuzumab | NA | biologic drug | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| miR-499-5p (and other miRNAs w/seed UAAGACU) | NA | mature microRNA | NA | NA | 1.0e-02 | CACNB2,SOX6 | NA |
| mir-32 | NA | microRNA | NA | NA | 1.0e-02 | BCL2L11,BTG2 | NA |
| BOK | -5.30e-01 | other | NA | NA | 1.0e-02 | CCNE1,ITPR1 | NA |
| NASP | 2.90e-01 | other | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| RNF139 | 2.10e-01 | enzyme | NA | NA | 1.0e-02 | FASN,FDFT1 | NA |
| ceralasertib | NA | chemical drug | NA | NA | 1.0e-02 | BTG2,CDKN1A | NA |
| RRM2B | -6.10e-01 | enzyme | NA | NA | 1.0e-02 | CDKN1A,TP53INP1 | NA |
| NDUFAB1 | 9.00e-02 | enzyme | NA | NA | 1.0e-02 | DBT,DLAT | NA |
| 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one | NA | chemical reagent | NA | NA | 1.0e-02 | BIRC2,BIRC3 | NA |
| SRT2183 | NA | chemical reagent | NA | NA | 1.0e-02 | FASN,LDLR | NA |
| 1,5-dihydroxyisoquinoline | NA | chemical reagent | NA | NA | 1.0e-02 | EDNRA,EDNRB | NA |
| entacapone | NA | chemical drug | NA | NA | 1.0e-02 | DACT1,JUN | NA |
| methylpiperidinyl-3b-hydroxycholenamide | NA | chemical reagent | NA | NA | 1.0e-02 | DHCR24,LDLR | NA |
| SMAD1/5/9 | NA | group | NA | NA | 1.0e-02 | CDKN1A,S1PR2 | NA |
| MECOM | NA | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,GADD45G,MAP3K14,SCUBE3,SERPINE1 | NA |
| PC-SPES | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CCNE1,CCNG1,CDKN1A,FDFT1,HERPUD1,IRF1,LAMC1,SELENBP1,SEPHS2 | NA |
| Srebp | NA | group | NA | NA | 1.0e-02 | CDKN1A,FASN,LDLR,NPC1 | NA |
| PPP1R15A | NA | other | NA | NA | 1.0e-02 | CCND1,CEBPB,MAP1LC3B,XBP1 | NA |
| NKX3-1 | NA | transcription regulator | NA | NA | 1.0e-02 | BTG2,CA12,FKBP5,PIK3R1,RAMP1,SDC4,STAT3 | NA |
| BBP-398 | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,DUSP6,ETV5 | NA |
| 2,5-bis(5-hydroxymethyl-2-thienyl)furan | NA | chemical reagent | NA | NA | 1.0e-02 | CDKN1A,RNF8,WNT4 | NA |
| IFN Lambda | NA | group | NA | NA | 1.0e-02 | IFIT3,Oas1b,OAS2 | NA |
| ATP6AP2 | 2.00e-02 | transporter | NA | NA | 1.0e-02 | AGT,NOX4,TGFB1 | NA |
| FOXK2 | NA | transcription regulator | NA | NA | 1.0e-02 | CDC14A,SERPINE1,XBP1 | NA |
| isoleucine | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CDKN1A,DBT,PPM1K | NA |
| MED14 | 1.20e-01 | transcription regulator | NA | NA | 1.0e-02 | CIDEC,IGFBP1,NR3C1 | NA |
| NRG4 | 1.06e+00 | growth factor | NA | NA | 1.0e-02 | CIDEC,FASN,GCK | NA |
| SH3KBP1 | -3.10e-01 | other | NA | NA | 1.0e-02 | CCND2,SERPINE1,XBP1 | NA |
| PIAS2 | -1.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,IRF1,LDLR | NA |
| PDE3B | 6.00e-01 | enzyme | NA | NA | 1.0e-02 | FASN,PPARGC1A,SERPINE1 | NA |
| CARM1 | 6.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CCNE1,CDKN1A,DDIT4,EPHX2,MTSS1,PFKFB2 | NA |
| MEF2 | NA | group | NA | NA | 2.0e-02 | DLL4,IL1RN,JUN,MEOX2,PPARGC1A | NA |
| Cdk | NA | group | NA | NA | 2.0e-02 | DDIT4,Esrra,GADD45G,IDH3A,PPARGC1A | NA |
| CNOT7 | 8.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CLDN1,CMPK2,IFI44L,OAS2,PPM1K | NA |
| Igm | NA | complex | NA | NA | 2.0e-02 | BCL2L11,CCND2,CDKN1A,FAS,ID3,TNFRSF14,XBP1,ZFP36L1 | NA |
| SERPINA3 | NA | other | NA | NA | 2.0e-02 | FOXO1,LDLR,NOX4,RIPK3 | NA |
| HMGA2 | NA | enzyme | NA | NA | 2.0e-02 | ID2,IL15,KLF15,STAT3 | NA |
| GLIS2 | -1.80e-01 | transcription regulator | NA | NA | 2.0e-02 | CCND1,IL15,IL33,SERPINE1,TGFB1 | NA |
| MYOC | 5.00e-02 | other | NA | NA | 2.0e-02 | ADAMTS1,CARD10,CHRDL1,DDIT4,FSCN1,LAMC1,MAFK,SESN2,STC1 | NA |
| ACVR1 | -5.20e-01 | kinase | NA | NA | 2.0e-02 | ALPL,CDKN1A,HNF4A,ID2,IL33,RNF157 | NA |
| zidovudine | NA | chemical drug | NA | NA | 2.0e-02 | BCL3,CCND2,CDKN1A,CPT1A | NA |
| Gli | NA | group | NA | NA | 2.0e-02 | CCND1,CCND2,FOXA2,IL6R | NA |
| diallyl trisulfide | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | CDKN1A,FAS,JUN,NFE2L2 | NA |
| teniposide | NA | chemical drug | NA | NA | 2.0e-02 | CDKN1A,FAS | NA |
| tauromuricholic acid | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | ACO2,CPT1A | NA |
| CF-02 | NA | chemical reagent | NA | NA | 2.0e-02 | NLRP3,PYCARD | NA |
| SIRT | NA | group | NA | NA | 2.0e-02 | FASN,LDLR | NA |
| CpG ODN 1555 | NA | chemical reagent | NA | NA | 2.0e-02 | IL15,IL15RA | NA |
| SLC22A2 | 4.00e-02 | transporter | NA | NA | 2.0e-02 | CPT1A,CPT2 | NA |
| ENHO | 1.40e-01 | other | NA | NA | 2.0e-02 | FOXO1,GCK | NA |
| DACT1 | -1.11e+00 | other | NA | NA | 2.0e-02 | CCND1,JUN | NA |
| FOXN4 | 1.00e-02 | transcription regulator | NA | NA | 2.0e-02 | DLL4,NR4A2 | NA |
| Gpcr | NA | group | NA | NA | 2.0e-02 | JUN,RGS1 | NA |
| JADE2 | -1.00e-02 | enzyme | NA | NA | 2.0e-02 | BTG2,TOMM20 | NA |
| ZMIZ2 | -2.70e-01 | transcription regulator | NA | NA | 2.0e-02 | CCND1,JUN | NA |
| ZNF598 | 6.00e-02 | enzyme | NA | NA | 2.0e-02 | IFI44,RSAD2 | NA |
| SLU7 | 3.50e-01 | enzyme | NA | NA | 2.0e-02 | BCL2L11,CDKN1A | NA |
| CREB3L4 | -5.80e-01 | transcription regulator | NA | NA | 2.0e-02 | ANKH,ID2 | NA |
| PU-H71 | NA | chemical drug | NA | NA | 2.0e-02 | LYN,SYK | NA |
| 7S NGF | NA | complex | NA | NA | 2.0e-02 | GCLM,NFE2L2 | NA |
| EIF3I | -5.00e-02 | translation regulator | NA | NA | 2.0e-02 | CCND1,SERPINE1 | NA |
| Atf | NA | group | NA | NA | 2.0e-02 | JUN,RB1 | NA |
| MIR3936HG | NA | other | NA | NA | 2.0e-02 | CCND1,CCNE1 | NA |
| IL31RA | 7.00e-02 | transmembrane receptor | NA | NA | 2.0e-02 | CISH,SOCS2 | NA |
| Hotair | NA | other | NA | NA | 2.0e-02 | HNF1A,HNF4A | NA |
| ZBTB46 | 2.90e-01 | transcription regulator | NA | NA | 2.0e-02 | PHF7,STAT3 | NA |
| TYMS | -7.00e-02 | enzyme | NA | NA | 2.0e-02 | CDKN1A,FAS | NA |
| RBM14 | -5.50e-01 | transcription regulator | NA | NA | 2.0e-02 | CCND1,SOX6 | NA |
| FLOT1 | -2.10e-01 | other | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| EXO1 | 1.40e-01 | enzyme | NA | NA | 2.0e-02 | IFI44,IFIT3 | NA |
| ACOD1 | 5.70e-01 | enzyme | NA | NA | 2.0e-02 | NFE2L2,TNFAIP3 | NA |
| RBBP8 | 4.10e-01 | enzyme | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| PLK3 | 2.21e+00 | kinase | NA | NA | 2.0e-02 | CDKN1A,FAS | NA |
| GNL2 | 6.70e-01 | enzyme | NA | NA | 2.0e-02 | CCNE1,CDKN1A | NA |
| HLA-B | NA | transmembrane receptor | NA | NA | 2.0e-02 | ELAVL1,OAS2 | NA |
| KRT10 | NA | other | NA | NA | 2.0e-02 | CCND1,CCNE1 | NA |
| GCLM | -8.60e-01 | enzyme | NA | NA | 2.0e-02 | GCLM,JUN | NA |
| MI-773 | NA | chemical drug | NA | NA | 2.0e-02 | BCL2L11,CDKN1A | NA |
| H3B-8800 | NA | chemical drug | NA | NA | 2.0e-02 | CXCL11,MX1 | NA |
| cimetidine | NA | chemical drug | NA | NA | 2.0e-02 | FAS,GDF15 | NA |
| miconazole | NA | chemical drug | NA | NA | 2.0e-02 | NR1I2,TAT | NA |
| 3-hydroxymorphinan | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | EGF,TGFB1 | NA |
| CBFB-MYH11 | NA | fusion gene/product | NA | NA | 2.0e-02 | ATF3,JUN | NA |
| ladostigil | NA | chemical drug | NA | NA | 2.0e-02 | PIK3R1,RB1,TFRC | NA |
| KDM4D | 3.00e-02 | enzyme | NA | NA | 2.0e-02 | CCND1,CD274,CDKN1A | NA |
| EHD1 | 2.30e-01 | other | NA | NA | 2.0e-02 | CCND1,GDF15,GYS1 | NA |
| CTNNBIP1 | 3.70e-01 | other | NA | NA | 2.0e-02 | CCND1,CDKN1A,HMGCS1 | NA |
| TWIST | NA | group | NA | NA | 2.0e-02 | B4GALNT1,CDKN1A,ST3GAL5 | NA |
| IFNL4 | NA | cytokine | NA | NA | 2.0e-02 | CXCL11,MX1,OAS2 | NA |
| ACO1 | 7.00e-02 | enzyme | NA | NA | 2.0e-02 | ACO2,IGFBP1,TFRC | NA |
| iodoacetic acid | NA | chemical toxicant | NA | NA | 2.0e-02 | ATF3,IL15,TGFB1 | NA |
| gamma-linolenic acid | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | FASN,PLIN4,PLIN5 | NA |
| gambogic acid | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | BIRC2,BIRC3,CCND1 | NA |
| Histone h4 | NA | group | NA | NA | 2.0e-02 | AGT,CCND1,CCNE1,CDKN1A,FAS,FASN,GADD45B,IGFBP1,IRF1,STAT3,TNFAIP3,TRPV6,Wasl | NA |
| ADCY | NA | group | NA | NA | 2.0e-02 | CDKN1A,CREM,NR4A2,PER1 | NA |
| LYL1 | -3.70e-01 | transcription regulator | NA | NA | 2.0e-02 | BTG2,ID3,ID4,RCBTB2 | NA |
| Mt2 | NA | other | NA | NA | 2.0e-02 | ATF3,CCND1,JUN,SERPINE1 | NA |
| TFDP1 | 2.20e-01 | transcription regulator | NA | NA | 2.0e-02 | CCND1,CCNE1,CDKN1A,FGFR2,PPP1R26 | NA |
| ACVRL1 | -2.90e-01 | kinase | NA | NA | 2.0e-02 | CDKN1A,EFNA1,GDF15,ID2,SERPINE1 | NA |
| acyline | NA | biologic drug | NA | NA | 2.0e-02 | FGFR2,GADD45B,GADD45G,JUN,LDLR,MAFB,PIM3,RPS18,SLC1A4,THRB | NA |
| L-methionine | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | ASNS,CDK19,DDIT4,GADD45B,IGFBP1,MAT1A,RHOB | NA |
| GHR | -1.60e-01 | transmembrane receptor | NA | NA | 2.0e-02 | CCND1,CCNE1,CDKN1A,CISH,IGFBP1,ONECUT1,SOCS2 | NA |
| moxonidine | NA | chemical drug | NA | NA | 2.0e-02 | CDKN1A,LRP2,TGFB1 | NA |
| Ck2 alpha | NA | group | NA | NA | 2.0e-02 | BIRC2,BIRC3,Mx2 | NA |
| GON4L | 1.40e-01 | transcription regulator | NA | NA | 2.0e-02 | CCND1,CCND2,CCNF | NA |
| Ahr-aryl hydrocarbon-Arnt | NA | complex | NA | NA | 2.0e-02 | CDKN1A,FAS,NFE2L2 | NA |
| withaferin A | NA | chemical reagent | NA | NA | 2.0e-02 | BCL2L11,CDKN1A,SERPINE1 | NA |
| TLE1 | 1.50e-01 | transcription regulator | NA | NA | 2.0e-02 | ATF3,MEIS2,NUPR1 | NA |
| LCOR | NA | transcription regulator | NA | NA | 2.0e-02 | CDKN1A,FKBP5,IGFBP1 | NA |
| AIF1 | -1.90e-01 | other | NA | NA | 2.0e-02 | CCND1,CCNE1,TGFB1 | NA |
| SAT1 | 1.50e-01 | enzyme | NA | NA | 2.0e-02 | CDKN1A,KLF9,PPARGC1A | NA |
| VLDLR | -2.20e-01 | transporter | NA | NA | 2.0e-02 | SERPINE1,STAT3,TNFAIP3 | NA |
| HOXA4 | -3.00e-01 | transcription regulator | NA | NA | 2.0e-02 | CCND1,CCND2,CCNE1 | NA |
| NPFF | -2.40e-01 | other | NA | NA | 2.0e-02 | CEBPB,ID3,PIK3R1 | NA |
| clasto-lactacystin beta-lactone | NA | chemical - protease inhibitor | NA | NA | 2.0e-02 | ATF3,MAPK6,NR1I2 | NA |
| noscapine | NA | chemical drug | NA | NA | 2.0e-02 | BIRC2,BIRC3,CCND1 | NA |
| thermozymocidin | NA | chemical reagent | NA | NA | 2.0e-02 | NLRP3,PYCARD,TNFAIP3 | NA |
| fish oils | NA | chemical drug | NA | NA | 2.0e-02 | CEBPB,CPT1A,FASN,NR1I2,NRIP1,PIK3R1 | NA |
| KLF1 | -3.80e-01 | transcription regulator | NA | NA | 2.0e-02 | Cd24a,CDKN1A,EPB41,IL17RB,SLC3A2,TFRC | NA |
| FGF4 | NA | growth factor | NA | NA | 2.0e-02 | CDKN1A,FOXA2,FOXO1,HMGCS1 | NA |
| MSX1 | 1.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A,EPHA4,IGFBP1,SYCP3 | NA |
| RNASEH2A | -3.40e-01 | enzyme | NA | NA | 3.0e-02 | GBP2,IFI44,IFIT3,IRF1,PARP9,RSAD2 | NA |
| sulindac | NA | chemical drug | NA | NA | 3.0e-02 | CCND1,CCNE1,CCNG1,CDKN1A,PLA2G4A,RB1,WEE1 | NA |
| CP-55940 | NA | chemical reagent | NA | NA | 3.0e-02 | BTG2,CCNE1,JUN,TNFAIP3,UBC | NA |
| eprenetapopt | NA | chemical drug | NA | NA | 3.0e-02 | CARD10,GADD45B,LIMK2,SLC7A5,XBP1 | NA |
| GAC0001E5 | NA | chemical reagent | NA | NA | 3.0e-02 | ASNS,GOT1 | NA |
| antrodia camphorata polysaccharide | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | NLRP3,PYCARD | NA |
| IXA4 | NA | chemical reagent | NA | NA | 3.0e-02 | SEC24D,XBP1 | NA |
| warburgia ugandensis dimethyl carbonate extract | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | CCND1,CCNE1 | NA |
| SERCA | NA | group | NA | NA | 3.0e-02 | BTG2,JUN | NA |
| vanillyl-N-nonylamide | NA | chemical drug | NA | NA | 3.0e-02 | ATF3,CCND1 | NA |
| MN1 | 0.00e+00 | other | NA | NA | 3.0e-02 | BCL2L11,TNFRSF11B | NA |
| DLX6-AS1 | NA | other | NA | NA | 3.0e-02 | CDKN1A,WEE1 | NA |
| PIWIL4 | 1.40e-01 | other | NA | NA | 3.0e-02 | FGFR2,TGFB1 | NA |
| AQP11 | 4.80e-01 | transporter | NA | NA | 3.0e-02 | EGF,TGFB1 | NA |
| CLEC12A | -5.20e-01 | other | NA | NA | 3.0e-02 | IFIT3,RSAD2 | NA |
| corticotropin | NA | biologic drug | NA | NA | 3.0e-02 | PCSK6,SUMO3 | NA |
| 2-chlorohexadecanoic acid | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | CIDEC,CPT1A | NA |
| vaccenic acid | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | PLIN4,PLIN5 | NA |
| ZNF207 | -2.30e-01 | transcription regulator | NA | NA | 3.0e-02 | MBNL2,RBM3 | NA |
| BCL2L12 | 2.30e-01 | other | NA | NA | 3.0e-02 | CCNG1,CDKN1A | NA |
| ABHD5 | -1.13e+00 | enzyme | NA | NA | 3.0e-02 | PNPLA2,TGM1 | NA |
| schizandrin B | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | MAP3K5,TGFB1 | NA |
| ENT | NA | group | NA | NA | 3.0e-02 | CDKN1A,FAS | NA |
| MAPKAPK5 | 1.20e-01 | kinase | NA | NA | 3.0e-02 | MAPK6,TNFAIP3 | NA |
| MAGED1 | 1.00e-01 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,JUN | NA |
| ELMO1 | -3.50e-01 | other | NA | NA | 3.0e-02 | NOX4,TGFB1 | NA |
| RNF111 | -1.80e-01 | enzyme | NA | NA | 3.0e-02 | FOXA2,SERPINE1 | NA |
| ATP6V0A2 | NA | transporter | NA | NA | 3.0e-02 | ARG1,TGFB1 | NA |
| SENP6 | 7.00e-02 | peptidase | NA | NA | 3.0e-02 | BIRC2,CD274 | NA |
| ECT2 | 3.30e-01 | other | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| EIF5A2 | -3.00e-01 | translation regulator | NA | NA | 3.0e-02 | PEAK1,TGFB1 | NA |
| TRPV6 | 6.40e-01 | ion channel | NA | NA | 3.0e-02 | TGM1,TRPV6 | NA |
| BTG1 | 6.00e-02 | transcription regulator | NA | NA | 3.0e-02 | JUN,NR3C1 | NA |
| MATK | 1.60e-01 | kinase | NA | NA | 3.0e-02 | ALPL,LYN | NA |
| tofogliflozin | NA | chemical drug | NA | NA | 3.0e-02 | CPT1A,FASN | NA |
| Gm35986 | NA | other | NA | NA | 3.0e-02 | FDFT1,HMGCS1 | NA |
| CDH13 | -4.00e-01 | other | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| OBP2B | NA | transporter | NA | NA | 3.0e-02 | CPT1A,FASN | NA |
| CXXC4 | -5.90e-01 | other | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| coxsackievirus A21 | NA | biologic drug | NA | NA | 3.0e-02 | CD274,CXCL11 | NA |
| furosemide | NA | chemical drug | NA | NA | 3.0e-02 | REN,SLC12A3 | NA |
| arginine methyltransferase inhibitor-1 | NA | chemical reagent | NA | NA | 3.0e-02 | CEBPB,PPARGC1A | NA |
| etomidate | NA | chemical drug | NA | NA | 3.0e-02 | CISH,NR3C1 | NA |
| eprosartan | NA | chemical drug | NA | NA | 3.0e-02 | SERPINE1,TGFB1 | NA |
| dibenzoylmethane | NA | chemical toxicant | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| salvianolic acid A | NA | chemical drug | NA | NA | 3.0e-02 | DUSP6,NOX4 | NA |
| gingerenone A | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | CDKN1A,SERPINE1 | NA |
| PK11007 | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A,XBP1 | NA |
| malondialdehyde | NA | chemical toxicant | NA | NA | 3.0e-02 | CDKN1A,TGFB1 | NA |
| sevelamer | NA | chemical drug | NA | NA | 3.0e-02 | CYP7A1,SLC34A2 | NA |
| GCN2iA | NA | chemical drug | NA | NA | 3.0e-02 | ASNS,EGF | NA |
| 10,12-tricosadiynoic acid | NA | chemical reagent | NA | NA | 3.0e-02 | CPT1A,PPARGC1A | NA |
| Boc-D-FMK | NA | chemical reagent | NA | NA | 3.0e-02 | RB1,SYK | NA |
| Z-VEID-FMK | NA | chemical reagent | NA | NA | 3.0e-02 | CCND1,CCND2 | NA |
| sparfosic acid | NA | chemical drug | NA | NA | 3.0e-02 | BCL2L11,CDKN1A | NA |
| 3’,4’,7-trihydroxyisoflavone | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | CCND1,CCNE1 | NA |
| 1’-acetoxychavicol acetate | NA | chemical reagent | NA | NA | 3.0e-02 | BIRC2,BIRC3,CCND1 | NA |
| CRTC3 | -3.40e-01 | other | NA | NA | 3.0e-02 | Esrra,IDH3A,PPARGC1A | NA |
| SNORD22 | NA | other | NA | NA | 3.0e-02 | CCND1,CCND2,CCNE1 | NA |
| SELENOS | 4.40e-01 | other | NA | NA | 3.0e-02 | CEBPB,FASN,XBP1 | NA |
| CLCN5 | -2.30e-01 | ion channel | NA | NA | 3.0e-02 | CCNE1,LRP2,SLC34A2 | NA |
| IGFBP7 | -5.00e-02 | transporter | NA | NA | 3.0e-02 | ASNS,CCND1,CDKN1A | NA |
| FERMT2 | 2.00e-02 | other | NA | NA | 3.0e-02 | CCND1,FASN,FOXO1 | NA |
| BDKRB2 | -5.00e-02 | G-protein coupled receptor | NA | NA | 3.0e-02 | FOXO1,REN,TGFB1 | NA |
| TRRAP | -1.00e-02 | transcription regulator | NA | NA | 3.0e-02 | BCL2L11,CCND2,CDKN1A | NA |
| CYP51A1 | 2.00e-02 | enzyme | NA | NA | 3.0e-02 | DHCR24,MSMO1,SQLE | NA |
| RGS1 | 1.27e+00 | enzyme | NA | NA | 3.0e-02 | IL15,IL15RA,INHBA | NA |
| DEK | -1.60e-01 | transcription regulator | NA | NA | 3.0e-02 | BIRC3,CDKN1A,CSF3R | NA |
| oligomycin | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | CCND2,DDIT4,SESN2 | NA |
| perindopril | NA | chemical drug | NA | NA | 3.0e-02 | EGF,REN,TGFB1 | NA |
| pyridoxine | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | FZD1,JUN,WNT4 | NA |
| ethylene dimethanesulfonate | NA | chemical reagent | NA | NA | 3.0e-02 | CYP17A1,FAS,Hsd3b4 (includes others) | NA |
| Mn(III)-tetrakis-(4-benzoic acid) porphyrin | NA | chemical reagent | NA | NA | 3.0e-02 | AGT,SERPINE1,TGFB1 | NA |
| zinc protoporphyrin IX | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | CCND1,CDKN1A,FGFR2 | NA |
| asiatic acid | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A,FAS,PPARGC1A | NA |
| U18666A | NA | chemical reagent | NA | NA | 3.0e-02 | DHCR24,NPC1,XBP1 | NA |
| 24-hydroxycholesterol | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | AGT,LDLR,REN | NA |
| CDK1 | 1.60e-01 | kinase | NA | NA | 3.0e-02 | CDKN1A,IL1RN,JUN,XBP1 | NA |
| STK4 | 5.80e-01 | kinase | NA | NA | 3.0e-02 | BCL2L11,FAS,FOXO1,IL15 | NA |
| MTA3 | 3.70e-01 | transcription regulator | NA | NA | 3.0e-02 | CD79B,SYK,TGFB1,XBP1 | NA |
| SRD5A1 | -1.30e-01 | enzyme | NA | NA | 3.0e-02 | CLDN1,CLDN2,FASN,PNPLA2 | NA |
| RRP1B | 5.60e-01 | transcription regulator | NA | NA | 3.0e-02 | AURKA,CCND1,CCNE1,CCNG1,CDKN1A,CEBPB,FANCB,FOXO1,ORC1,TGFB1 | NA |
| rasagiline | NA | chemical drug | NA | NA | 3.0e-02 | FAS,PIK3R1,RB1,SOS1,TFRC | NA |
| ZBTB17 | 1.10e-01 | transcription regulator | NA | NA | 3.0e-02 | BHLHE40,CCND1,CDKN1A,DDB2,JUN,LDLR,NOCT,ODC1 | NA |
| H2AZ1 | NA | other | NA | NA | 3.0e-02 | CCND1,CDKN1A,DLAT,FOXA2,HNF4A,TOMM40 | NA |
| BRD2 | -2.60e-01 | kinase | NA | NA | 3.0e-02 | CISH,DNAJA1,PAWR,PRKD3,SOX5,WEE1 | NA |
| leukotriene B4 | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | FASN,JUN,NOX4,PTPN1 | NA |
| MTA2 | 2.20e-01 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,ID2,JUN,SQLE | NA |
| SLC9A3 | -1.20e-01 | ion channel | NA | NA | 3.0e-02 | CCND1,Ifi47,Igtp,SLC26A3 | NA |
| Mt1 | 4.40e-01 | other | NA | NA | 3.0e-02 | ATF3,CCND1,JUN,SERPINE1 | NA |
| 4-nitroquinoline-1-oxide | NA | chemical toxicant | NA | NA | 3.0e-02 | AURKA,CCNE1,CD274,CDKN1A | NA |
| FOXA3 | 2.70e-01 | transcription regulator | NA | NA | 3.0e-02 | CPT1A,FOXA1,FOXA2,PPARGC1A,TAT | NA |
| Rxr | NA | group | NA | NA | 3.0e-02 | BTG2,CDKN1A,CPT1A,CYP26A1,CYP7A1,EFNA5,INSIG1,POR,PTPRO,SLCO1B3 | NA |
| cyclic GMP | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | CDKN1A,PPARGC1A,SERPINE1 | NA |
| glycerol | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | AGT,LDLR,NR3C1 | NA |
| epothilone B | NA | chemical drug | NA | NA | 3.0e-02 | BTG2,CDKN1A,FAS | NA |
| lonafarnib | NA | chemical drug | NA | NA | 3.0e-02 | BIRC2,BIRC3,CCND1 | NA |
| HOXA11-AS | NA | other | NA | NA | 3.0e-02 | CD274,CDKN1A,STAT3 | NA |
| LINC00662 | NA | other | NA | NA | 3.0e-02 | ARG1,CCND1,RNF144B | NA |
| PNPLA1 | -2.00e-02 | enzyme | NA | NA | 3.0e-02 | ABHD5,CERS3,PPARD | NA |
| ISGF3 | NA | complex | NA | NA | 3.0e-02 | IRF1,MX1,RSAD2 | NA |
| THRAP3 | 2.80e-01 | transcription regulator | NA | NA | 3.0e-02 | CCND1,Cd24a,NR3C1 | NA |
| KLF17 | NA | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,IL1RN,RB1 | NA |
| DPH5 | 2.00e-01 | enzyme | NA | NA | 3.0e-02 | EGF,IRF1,STAT3 | NA |
| TRIM31 | NA | enzyme | NA | NA | 3.0e-02 | CDKN1A,CPT1A,FASN | NA |
| alisertib | NA | chemical drug | NA | NA | 3.0e-02 | HAND2,PAX8,PPARGC1A | NA |
| ZFPM2 | -2.60e-01 | transcription regulator | NA | NA | 3.0e-02 | CYP17A1,HAND2,WNT4 | NA |
| SLC2A3 | -5.00e-02 | transporter | NA | NA | 3.0e-02 | ALDOA,PFKFB3,SLC16A4 | NA |
| BLNK | -4.00e-02 | other | NA | NA | 3.0e-02 | CCND2,FOXO1,JUN | NA |
| IGFBP1 | 1.44e+00 | other | NA | NA | 3.0e-02 | CEBPB,IGFBP1,TGFB1 | NA |
| DBI | -3.00e-02 | other | NA | NA | 3.0e-02 | FASN,PPARD,SQLE | NA |
| DGAT1 | 3.30e-01 | enzyme | NA | NA | 3.0e-02 | CPT1A,PNPLA2,PPARD | NA |
| vatalanib | NA | chemical drug | NA | NA | 3.0e-02 | CCND1,CCNE1,CDKN1A | NA |
| bosutinib | NA | chemical drug | NA | NA | 3.0e-02 | CCND1,CCNE1,EPHX2 | NA |
| cystamine | NA | chemical drug | NA | NA | 3.0e-02 | FAS,NR4A2,TNFRSF11B | NA |
| 2-acetylaminofluorene | NA | chemical toxicant | NA | NA | 3.0e-02 | CCND1,CDKN1A,DLL1 | NA |
| N1,N11-diethylnorspermine | NA | chemical drug | NA | NA | 3.0e-02 | CCND1,CDKN1A,SMOX | NA |
| farnesyl pyrophosphate | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | FASN,SERPINE1,TGFB1 | NA |
| CIRBP | 1.12e+00 | translation regulator | NA | NA | 4.0e-02 | CCND1,CCNE1,HHEX,VRK1 | NA |
| MC4R | NA | G-protein coupled receptor | NA | NA | 4.0e-02 | FASN,PNPLA2,PPARGC1A,UBC | NA |
| PKNOX1 | -5.00e-02 | transcription regulator | NA | NA | 4.0e-02 | AMD1,FABP7,PPARGC1A,REN | NA |
| SMARCC1 | 1.70e-01 | transcription regulator | NA | NA | 4.0e-02 | CCND1,CD79B,CDKN1A,LPIN1 | NA |
| oleanolic acid | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | CCND1,CDKN1A,CXCL11,NFE2L2,SYCP3 | NA |
| triolein | NA | chemical drug | NA | NA | 4.0e-02 | FASN,GCK | NA |
| OSMI-1 | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| olomoucine | NA | chemical - kinase inhibitor | NA | NA | 4.0e-02 | PCYT1A,RB1 | NA |
| histidinol | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | ASNS,SLC7A5 | NA |
| phlorizin | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | HNF1A,NR3C1 | NA |
| pervanadate | NA | chemical reagent | NA | NA | 4.0e-02 | IRF1,MX1 | NA |
| Histone H2b | NA | group | NA | NA | 4.0e-02 | Ifi47,IRF1 | NA |
| triamcinolone | NA | chemical drug | NA | NA | 4.0e-02 | CBS/LOC102724560,MAT1A | NA |
| cosyntropin | NA | biologic drug | NA | NA | 4.0e-02 | DHCR24,DLL4 | NA |
| 2-(3-hydroxypropoxy)calcitriol | NA | chemical drug | NA | NA | 4.0e-02 | S1PR2,SLC34A2 | NA |
| asparaginase | NA | group | NA | NA | 4.0e-02 | ASNS,EGF | NA |
| bis(3’,5’)-cyclic diguanylic acid | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | IL15,IL15RA | NA |
| PRDM4 | -1.40e-01 | transcription regulator | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| NSUN2 | 1.40e-01 | enzyme | NA | NA | 4.0e-02 | PCYT1A,PIK3R1 | NA |
| AKIRIN2 | -3.00e-02 | other | NA | NA | 4.0e-02 | CCND1,CCND2 | NA |
| PTK | NA | group | NA | NA | 4.0e-02 | NR3C1,TGFB1 | NA |
| ATE1 | -1.00e-01 | enzyme | NA | NA | 4.0e-02 | CCND1,JUN | NA |
| GYY 4137 | NA | chemical reagent | NA | NA | 4.0e-02 | CBS/LOC102724560,ITPR1 | NA |
| WDFY2 | -4.30e-01 | other | NA | NA | 4.0e-02 | ACO2,FASN | NA |
| HDGF | -9.00e-02 | growth factor | NA | NA | 4.0e-02 | SERPINE1,TGFB1 | NA |
| PCM1 | -2.60e-01 | other | NA | NA | 4.0e-02 | CDKN1A,RB1 | NA |
| IER3 | -4.40e-01 | other | NA | NA | 4.0e-02 | BIRC2,BIRC3 | NA |
| ACIN1 | -1.60e-01 | enzyme | NA | NA | 4.0e-02 | CYP26A1,FOXA1 | NA |
| PDE6B | -1.00e-02 | enzyme | NA | NA | 4.0e-02 | NFE2L2,RIPK3 | NA |
| WNT2 | -4.00e-01 | cytokine | NA | NA | 4.0e-02 | NOX4,TK1 | NA |
| TRPV2 | -3.50e-01 | ion channel | NA | NA | 4.0e-02 | CCNE1,FAS | NA |
| KLF12 | -8.60e-01 | transcription regulator | NA | NA | 4.0e-02 | IL15,IL1RN | NA |
| RGS6 | -2.70e-01 | enzyme | NA | NA | 4.0e-02 | SERPINE1,TK1 | NA |
| CBR3-AS1 | NA | other | NA | NA | 4.0e-02 | CCND1,TGFB1 | NA |
| WNK1 | -4.00e-02 | kinase | NA | NA | 4.0e-02 | SERPINE1,SLC12A3 | NA |
| GNE | -1.31e+00 | kinase | NA | NA | 4.0e-02 | ASNS,ST3GAL5 | NA |
| DAB2 | -2.40e-01 | other | NA | NA | 4.0e-02 | CCND1,LRP2 | NA |
| PHIP | 0.00e+00 | other | NA | NA | 4.0e-02 | CCND1,CCND2 | NA |
| miR-519a-3p (and other miRNAs w/seed AAGUGCA) | NA | mature microRNA | NA | NA | 4.0e-02 | ELAVL1,PRKAA1 | NA |
| mir-329 | NA | microRNA | NA | NA | 4.0e-02 | CCND1,DDIT4 | NA |
| MYCBP | 5.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CCND2,ODC1 | NA |
| EIF5A | 1.60e-01 | translation regulator | NA | NA | 4.0e-02 | CDKN1A,PEAK1 | NA |
| rigosertib | NA | chemical drug | NA | NA | 4.0e-02 | CCND1,ELAVL1 | NA |
| BANCR | NA | other | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| SLC22A1 | -1.30e-01 | transporter | NA | NA | 4.0e-02 | CPT1A,CPT2 | NA |
| BRCA2 | 2.10e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A,SERPINE1 | NA |
| IL17B | -2.70e-01 | cytokine | NA | NA | 4.0e-02 | CDKN1A,IL17RB | NA |
| RAD9A | 0.00e+00 | enzyme | NA | NA | 4.0e-02 | CDKN1A,KLF12 | NA |
| ERBIN | 0.00e+00 | other | NA | NA | 4.0e-02 | CDKN1A,SERPINE1 | NA |
| CAPNS1 | -1.60e-01 | peptidase | NA | NA | 4.0e-02 | CCND1,CCND2 | NA |
| NPAS2 | -2.30e-01 | transcription regulator | NA | NA | 4.0e-02 | PER1,PER2 | NA |
| CTH | NA | enzyme | NA | NA | 4.0e-02 | ASNS,CDKN1A | NA |
| glyceraldehyde-BSA | NA | chemical reagent | NA | NA | 4.0e-02 | CDKN1A,FASN | NA |
| methylglyoxal-BSA | NA | chemical reagent | NA | NA | 4.0e-02 | CDKN1A,FASN | NA |
| osimertinib | NA | chemical drug | NA | NA | 4.0e-02 | CD274,FASN | NA |
| PRN694 | NA | chemical drug | NA | NA | 4.0e-02 | NFKBIZ,TNFAIP3 | NA |
| nicorandil | NA | chemical drug | NA | NA | 4.0e-02 | ATF3,JUN | NA |
| diquat | NA | chemical toxicant | NA | NA | 4.0e-02 | GCLM,NFE2L2 | NA |
| 4-coumaric acid | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CDKN1A,ODC1 | NA |
| 2-mercaptoethanol | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | ATF3,HERPUD1 | NA |
| HI-TOPK32 | NA | chemical reagent | NA | NA | 4.0e-02 | JUN,SLC45A3 | NA |
| miR-508-3p inhibitor | NA | chemical reagent | NA | NA | 4.0e-02 | CLDN1,SERPINE1 | NA |
| tyrphostin AG825 | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A,LMO4 | NA |
| Muscarinic cholinergic receptor | NA | group | NA | NA | 4.0e-02 | ALPL,JUN | NA |
| N-acetyl-L-aspartic acid | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | ASPA,FASN | NA |
| ADP | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CREM,REN,SERPINE1 | NA |
| desoxycorticosterone | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | NOX4,SERPINE1,TGFB1 | NA |
| ZC3H14 | -2.50e-01 | other | NA | NA | 4.0e-02 | IL15,IL15RA,TSC22D1 | NA |
| IL13RA2 | -7.00e-01 | transmembrane receptor | NA | NA | 4.0e-02 | CLEC10A,LILRB3,TGFB1 | NA |
| SRSF3 | 3.90e-01 | other | NA | NA | 4.0e-02 | CCND1,CCNE1,JUN | NA |
| MMP8 | 7.00e-02 | peptidase | NA | NA | 4.0e-02 | CLDN3,NR3C1,TGFB1 | NA |
| CNOT3 | -1.00e-01 | other | NA | NA | 4.0e-02 | CDKN1A,IGFBP1,PPARGC1A | NA |
| decursin | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | CCND1,CDKN1A,FASN | NA |
| mevastatin | NA | chemical drug | NA | NA | 4.0e-02 | ADAMTS1,CDKN1A,LDLR | NA |
| amlodipine | NA | chemical drug | NA | NA | 4.0e-02 | CD274,LDLR,REN | NA |
| TCF3-PBX1 | NA | fusion gene/product | NA | NA | 4.0e-02 | ASNS,LZTS1,SYK | NA |
| 2-arachidonoylglycerol | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | LPIN1,PPARD,PPARGC1A | NA |
| ethidium | NA | chemical drug | NA | NA | 4.0e-02 | CCND1,CCNE1,SERPINE1 | NA |
| MSX2 | 3.00e-02 | transcription regulator | NA | NA | 4.0e-02 | ALPL,CCND1,EPHA4,IGFBP1,IHH | NA |
| ATF1 | 1.60e-01 | transcription regulator | NA | NA | 4.0e-02 | CEBPB,INHBA,JUN,PDE3B,REN | NA |
| EPOR | -1.70e-01 | transmembrane receptor | NA | NA | 4.0e-02 | CCND2,CISH,JUN,TFRC | NA |
| FANCC | -5.80e-01 | other | NA | NA | 4.0e-02 | ATP1B1,GDF15,HHEX,IFI44L,MX1,NR3C1,RND3 | NA |
| lipid | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | AGT,LDLR,PCYT1A,SQLE,STAT3 | NA |
| choline fenofibrate | NA | chemical drug | NA | NA | 4.0e-02 | CPT1A,NPC1,PCSK9,SERPINE1 | NA |
| GNAI2 | -3.00e-02 | enzyme | NA | NA | 4.0e-02 | BHLHE40,CCND1,PTPN1,STAT3 | NA |
| DLX6 | NA | transcription regulator | NA | NA | 4.0e-02 | CYP26A1,HAND2,UNC5C | NA |
| PI-103 | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L11,CCND1,CIDEC | NA |
| AGO1 | -9.00e-02 | translation regulator | NA | NA | 4.0e-02 | BCL2L11,CDKN1A,NRIP1 | NA |
| ERFE | -2.00e-02 | other | NA | NA | 4.0e-02 | ATOH8,ID2,TNFRSF11B | NA |
| PHLPP2 | 1.50e-01 | enzyme | NA | NA | 4.0e-02 | CPT1A,CPT2,MAP1LC3B | NA |
| PPP3CB | -4.10e-01 | phosphatase | NA | NA | 4.0e-02 | CDKN1A,KLRD1,NOX4 | NA |
| FMO3 | 8.30e-01 | enzyme | NA | NA | 4.0e-02 | FASN,FOXO1,PPARGC1A | NA |
| AKR1B1 | -2.50e-01 | enzyme | NA | NA | 4.0e-02 | CCND1,CDKN1A,CPT1A | NA |
| SOD3 | -1.00e-01 | enzyme | NA | NA | 4.0e-02 | EDNRA,EDNRB,TGFB1 | NA |
| CREB3 | 1.70e-01 | transcription regulator | NA | NA | 4.0e-02 | INSIG1,INSIG2,XBP1 | NA |
| XPO1 | -3.90e-01 | transporter | NA | NA | 4.0e-02 | CCND1,CDKN1A,ELAVL1 | NA |
| 10-(6’-ubiquinonyl)decyltriphenylphosphonium | NA | chemical drug | NA | NA | 4.0e-02 | CPT1A,NFE2L2,PPIF | NA |
| n-nitrosomethylbenzylamine | NA | chemical toxicant | NA | NA | 4.0e-02 | ALS2,CCND1,CLDN1,FTSJ3,GCLM,GSTT2/GSTT2B,MAPK6,PCSK9,PLK3,RB1,Srrm1 | NA |
| sn-1,2-didecanoylglycerol | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | ODC1 | NA |
| 9-hydroxy-(S)-10,12-octadecadienoic acid | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | SERPINE1 | NA |
| SZB120 | NA | chemical reagent | NA | NA | 4.0e-02 | NFKBIZ | NA |
| BLU 9931 | NA | chemical drug | NA | NA | 4.0e-02 | CCND1 | NA |
| 3-aminoisobutanoate | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CPT1A | NA |
| beta-escin | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| ergosterol | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | BCL2L11 | NA |
| Katp Channel (family) | NA | group | NA | NA | 4.0e-02 | PPARGC1A | NA |
| Collagen type VII | NA | complex | NA | NA | 4.0e-02 | SLCO1B3 | NA |
| Keratin 16 | NA | group | NA | NA | 4.0e-02 | CCND1 | NA |
| corticosterone acetate | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | IGFBP1 | NA |
| ErSO | NA | chemical reagent | NA | NA | 4.0e-02 | XBP1 | NA |
| S. pneumoniae glucosyl-diacylglycerol | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | NLRP3 | NA |
| cortivazol | NA | chemical reagent | NA | NA | 4.0e-02 | NR3C1 | NA |
| deflazacort | NA | chemical drug | NA | NA | 4.0e-02 | EDNRA | NA |
| LM-1685 | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1 | NA |
| miR-29c-3p inhibitor | NA | chemical reagent | NA | NA | 4.0e-02 | CEMIP | NA |
| eifsixty-6 | NA | chemical reagent | NA | NA | 4.0e-02 | CEBPB | NA |
| mitotam | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| eicosa-11Z, 14Z-dienoic acid | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | PNPLA2 | NA |
| GSK3203591 | NA | chemical reagent | NA | NA | 4.0e-02 | CD274 | NA |
| euxanthone | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | STC1 | NA |
| ES-072 | NA | chemical drug | NA | NA | 4.0e-02 | CD274 | NA |
| lapachol | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | SERPINE1 | NA |
| Ggt | NA | group | NA | NA | 4.0e-02 | SLC7A5 | NA |
| AMG-9810 | NA | chemical reagent | NA | NA | 4.0e-02 | PPARGC1A | NA |
| etarotene | NA | chemical reagent | NA | NA | 4.0e-02 | ODC1 | NA |
| budesonide/formoterol | NA | chemical drug | NA | NA | 4.0e-02 | CD274 | NA |
| G-Actin | NA | group | NA | NA | 4.0e-02 | JUN | NA |
| tandospirone | NA | chemical drug | NA | NA | 4.0e-02 | PER1 | NA |
| danshen extract | NA | chemical drug | NA | NA | 4.0e-02 | TGFB1 | NA |
| FER1L4 | NA | other | NA | NA | 4.0e-02 | RB1 | NA |
| PKR dimer | NA | complex | NA | NA | 4.0e-02 | ATF3 | NA |
| Ctla2a/Ctla2b | NA | other | NA | NA | 4.0e-02 | TGFB1 | NA |
| CLTA | -2.00e-02 | other | NA | NA | 4.0e-02 | LDLR | NA |
| CCPG1 | -6.00e-02 | other | NA | NA | 4.0e-02 | CD274 | NA |
| 9030622O22Rik | NA | other | NA | NA | 4.0e-02 | FOXA2 | NA |
| AAMP | 2.90e-01 | other | NA | NA | 4.0e-02 | CD274 | NA |
| RFX8 | -7.40e-01 | transcription regulator | NA | NA | 4.0e-02 | DDX24 | NA |
| HCG11 | NA | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| LINC00475 | NA | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| PPDPF | -2.50e-01 | other | NA | NA | 4.0e-02 | FASN | NA |
| NCK | NA | group | NA | NA | 4.0e-02 | CCND1 | NA |
| Tug1 | NA | other | NA | NA | 4.0e-02 | PPARGC1A | NA |
| SRP54 | 1.80e-01 | enzyme | NA | NA | 4.0e-02 | XBP1 | NA |
| DEPDC1B | 1.40e-01 | other | NA | NA | 4.0e-02 | SCUBE3 | NA |
| FBXO46 | 1.90e-01 | other | NA | NA | 4.0e-02 | FBXO31 | NA |
| ALG2 | -2.60e-01 | enzyme | NA | NA | 4.0e-02 | CREB3L2 | NA |
| ZC3H18 | 1.20e-01 | other | NA | NA | 4.0e-02 | CD274 | NA |
| INTS13 | -4.70e-01 | other | NA | NA | 4.0e-02 | CD274 | NA |
| SCAF8 | 6.40e-01 | other | NA | NA | 4.0e-02 | CD274 | NA |
| PCBP3 | -2.40e-01 | transcription regulator | NA | NA | 4.0e-02 | PFKFB3 | NA |
| IDH3B | NA | enzyme | NA | NA | 4.0e-02 | PFKFB3 | NA |
| KCNJ12 | -2.00e-02 | ion channel | NA | NA | 4.0e-02 | CCND1 | NA |
| NOC3L | 3.10e-01 | other | NA | NA | 4.0e-02 | CCNE1 | NA |
| ARMC10 | -1.40e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| CALCOCO1 | 4.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CCND1 | NA |
| URGCP | 6.20e-01 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| FKBPL | 3.90e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| ZBTB7C | -3.00e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| RND2 | 2.70e-01 | enzyme | NA | NA | 4.0e-02 | RHOB | NA |
| DEPDC1 | 3.00e-01 | transcription regulator | NA | NA | 4.0e-02 | TNFAIP3 | NA |
| RDH11 | 7.00e-02 | enzyme | NA | NA | 4.0e-02 | NR3C1 | NA |
| VIRMA | NA | other | NA | NA | 4.0e-02 | WEE1 | NA |
| CXXC1 | 1.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| RITA1 | 1.30e-01 | other | NA | NA | 4.0e-02 | AURKA | NA |
| CCDC22 | -9.00e-02 | other | NA | NA | 4.0e-02 | BIRC3 | NA |
| BLTP3A | NA | other | NA | NA | 4.0e-02 | THRB | NA |
| ZNF319 | -5.80e-01 | transcription regulator | NA | NA | 4.0e-02 | CD274 | NA |
| MPP3 | 1.20e-01 | kinase | NA | NA | 4.0e-02 | NECTIN1 | NA |
| PKD2L1 | 1.00e-01 | ion channel | NA | NA | 4.0e-02 | PKD1L3 | NA |
| CCDC62 | 8.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CCND1 | NA |
| TNRC18 | -5.20e-01 | other | NA | NA | 4.0e-02 | CD274 | NA |
| ZBTB8A | 3.60e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| PABIR1 | NA | other | NA | NA | 4.0e-02 | WEE1 | NA |
| TSKU | 1.00e-02 | other | NA | NA | 4.0e-02 | TGFB1 | NA |
| HASPIN | NA | kinase | NA | NA | 4.0e-02 | CDKN1A | NA |
| CMTM4 | -2.30e-01 | cytokine | NA | NA | 4.0e-02 | CD274 | NA |
| RX 77368 | NA | chemical reagent | NA | NA | 4.0e-02 | NOX4 | NA |
| KCTD10 | 4.00e-02 | ion channel | NA | NA | 4.0e-02 | RHOB | NA |
| PNISR | 1.40e-01 | other | NA | NA | 4.0e-02 | CD274 | NA |
| CMTM6 | -4.50e-01 | cytokine | NA | NA | 4.0e-02 | CD274 | NA |
| TAOK1 | 1.40e-01 | kinase | NA | NA | 4.0e-02 | MX1 | NA |
| PLAC1 | NA | other | NA | NA | 4.0e-02 | CCND1 | NA |
| ZNF687 | 3.00e-02 | transcription regulator | NA | NA | 4.0e-02 | THRB | NA |
| FANK1 | -1.70e-01 | transcription regulator | NA | NA | 4.0e-02 | JUN | NA |
| PCGF5 | -7.00e-02 | other | NA | NA | 4.0e-02 | MCC | NA |
| DRAM1 | -1.90e-01 | other | NA | NA | 4.0e-02 | VRK1 | NA |
| nitecapone | NA | chemical reagent | NA | NA | 4.0e-02 | TGFB1 | NA |
| cis-vaccenic acid | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | PNPLA2 | NA |
| 7-bromoindirubin-3’-oxime | NA | chemical - kinase inhibitor | NA | NA | 4.0e-02 | CDKN1A | NA |
| cabozantinib | NA | chemical drug | NA | NA | 4.0e-02 | CD274 | NA |
| NNZ 2566 | NA | biologic drug | NA | NA | 4.0e-02 | ATF3 | NA |
| eprotirome | NA | chemical drug | NA | NA | 4.0e-02 | CYP7A1 | NA |
| black cohosh extract | NA | chemical drug | NA | NA | 4.0e-02 | SERPINE1 | NA |
| inolitazone | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| fostamatinib | NA | chemical drug | NA | NA | 4.0e-02 | PAWR | NA |
| HCV 796 | NA | chemical drug | NA | NA | 4.0e-02 | MAP1LC3B | NA |
| Integrin alpha 5 beta 1 | NA | complex | NA | NA | 4.0e-02 | CCND1 | NA |
| Mapk kinase | NA | group | NA | NA | 4.0e-02 | CCND1 | NA |
| Rho gdi | NA | group | NA | NA | 4.0e-02 | RHOB | NA |
| DLAT | 6.10e-01 | enzyme | NA | NA | 4.0e-02 | CISH | NA |
| EIF3J | 1.10e-01 | translation regulator | NA | NA | 4.0e-02 | CD274 | NA |
| PF-4523655 | NA | biologic drug | NA | NA | 4.0e-02 | DDIT4 | NA |
| mubritinib | NA | chemical drug | NA | NA | 4.0e-02 | MAF | NA |
| PRCC | 2.00e-01 | other | NA | NA | 4.0e-02 | SERPINE1 | NA |
| 5-fluorouracil/irinotecan/leucovorin | NA | chemical drug | NA | NA | 4.0e-02 | XBP1 | NA |
| PC | -1.10e-01 | enzyme | NA | NA | 4.0e-02 | FASN | NA |
| PF-3758309 | NA | chemical drug | NA | NA | 4.0e-02 | PTK6 | NA |
| Tenascin | NA | group | NA | NA | 4.0e-02 | CCND1 | NA |
| NDUFV1 | 1.20e-01 | enzyme | NA | NA | 4.0e-02 | PTPN1 | NA |
| afuresertib | NA | chemical drug | NA | NA | 4.0e-02 | CBLB | NA |
| DYNLRB1 | -6.00e-02 | other | NA | NA | 4.0e-02 | SERPINE1 | NA |
| GTF2H2 | 1.00e-01 | transcription regulator | NA | NA | 4.0e-02 | KLF9 | NA |
| OSTN | -4.00e-02 | other | NA | NA | 4.0e-02 | PPARGC1A | NA |
| SRSF9 | -1.50e-01 | enzyme | NA | NA | 4.0e-02 | NR3C1 | NA |
| CABLES1 | -4.00e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| CDT1 | 8.80e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| SLC10A2 | NA | transporter | NA | NA | 4.0e-02 | CYP7A1 | NA |
| MED7 | -9.00e-02 | transcription regulator | NA | NA | 4.0e-02 | TNFAIP3 | NA |
| ACVR2B | 1.50e-01 | kinase | NA | NA | 4.0e-02 | CDKN1A | NA |
| EXTL2 | 1.80e-01 | enzyme | NA | NA | 4.0e-02 | SDC4 | NA |
| MKRN1 | NA | enzyme | NA | NA | 4.0e-02 | KCNH1 | NA |
| Mkrn1 | 2.10e-01 | enzyme | NA | NA | 4.0e-02 | KCNH1 | NA |
| SELENOT | -1.00e-01 | enzyme | NA | NA | 4.0e-02 | NOX4 | NA |
| ADCY2 | -3.20e-01 | enzyme | NA | NA | 4.0e-02 | CCND1 | NA |
| CLTB | 9.00e-02 | other | NA | NA | 4.0e-02 | LDLR | NA |
| Lysosomal Protease | NA | group | NA | NA | 4.0e-02 | MAP1LC3B | NA |
| miR-523-3p (miRNAs w/seed AACGCGC) | NA | mature microRNA | NA | NA | 4.0e-02 | CDKN1A | NA |
| miR-675-5p (and other miRNAs w/seed GGUGCGG) | NA | mature microRNA | NA | NA | 4.0e-02 | RB1 | NA |
| miR-409-3p (miRNAs w/seed AAUGUUG) | NA | mature microRNA | NA | NA | 4.0e-02 | LMO4 | NA |
| miR-513a-5p (miRNAs w/seed UCACAGG) | NA | mature microRNA | NA | NA | 4.0e-02 | CD274 | NA |
| miR-1468-5p (miRNAs w/seed UCCGUUU) | NA | mature microRNA | NA | NA | 4.0e-02 | CD274 | NA |
| mir-617 | NA | microRNA | NA | NA | 4.0e-02 | SERPINE1 | NA |
| miR-1252-5p (miRNAs w/seed GAAGGAA) | NA | mature microRNA | NA | NA | 4.0e-02 | PFKFB2 | NA |
| miR-605-5p (miRNAs w/seed AAAUCCC) | NA | mature microRNA | NA | NA | 4.0e-02 | SEC24D | NA |
| miR-706 (miRNAs w/seed GAGAAAC) | NA | mature microRNA | NA | NA | 4.0e-02 | SLC3A2 | NA |
| R333 | NA | chemical drug | NA | NA | 4.0e-02 | MAF | NA |
| IPO5 | 1.50e-01 | transporter | NA | NA | 4.0e-02 | IL33 | NA |
| COPZ1 | 3.00e-02 | transporter | NA | NA | 4.0e-02 | NCOA4 | NA |
| TIMELESS | -2.00e-01 | other | NA | NA | 4.0e-02 | PER1 | NA |
| IFI6 | NA | other | NA | NA | 4.0e-02 | BCL2L11 | NA |
| AX 115 | NA | chemical reagent | NA | NA | 4.0e-02 | PLA2G4A | NA |
| ZBTB5 | 3.20e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| DHX8 | 1.00e-02 | enzyme | NA | NA | 4.0e-02 | CDKN1A | NA |
| BORCS8-MEF2B | NA | transcription regulator | NA | NA | 4.0e-02 | JUN | NA |
| GJA5 | -3.40e-01 | transporter | NA | NA | 4.0e-02 | REN | NA |
| RB1-DT | NA | other | NA | NA | 4.0e-02 | RB1 | NA |
| atacicept | NA | biologic drug | NA | NA | 4.0e-02 | IL15 | NA |
| ponatinib | NA | chemical drug | NA | NA | 4.0e-02 | DHCR24 | NA |
| icaritin | NA | chemical drug | NA | NA | 4.0e-02 | CD274 | NA |
| CAMK2 | NA | group | NA | NA | 4.0e-02 | BIRC3 | NA |
| ZNF613 | 3.60e-01 | transcription regulator | NA | NA | 4.0e-02 | ID2 | NA |
| LINC00278 | NA | other | NA | NA | 4.0e-02 | EEF2K | NA |
| thiazide diuretic | NA | chemical drug | NA | NA | 4.0e-02 | SLC12A3 | NA |
| COL4A2 | 4.00e-02 | other | NA | NA | 4.0e-02 | FAS | NA |
| TOB2 | 1.40e-01 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| CDC16 | 8.00e-02 | other | NA | NA | 4.0e-02 | SCUBE3 | NA |
| CUBN | 5.30e-01 | transmembrane receptor | NA | NA | 4.0e-02 | NLRP3 | NA |
| GTPBP4 | 7.80e-01 | enzyme | NA | NA | 4.0e-02 | CCND1 | NA |
| P2RX1 | 5.00e-02 | ion channel | NA | NA | 4.0e-02 | CD274 | NA |
| RNF7 | 1.30e-01 | enzyme | NA | NA | 4.0e-02 | JUN | NA |
| AURKAIP1 | NA | enzyme | NA | NA | 4.0e-02 | AURKA | NA |
| DNASE1L3 | -4.80e-01 | enzyme | NA | NA | 4.0e-02 | CDKN1A | NA |
| PSMC4 | 1.80e-01 | peptidase | NA | NA | 4.0e-02 | CCND2 | NA |
| CCNI | -1.80e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| RPL18 | 1.00e-02 | other | NA | NA | 4.0e-02 | CD274 | NA |
| FXYD1 | -1.60e-01 | ion channel | NA | NA | 4.0e-02 | CDKN1A | NA |
| PTPRU | 5.30e-01 | phosphatase | NA | NA | 4.0e-02 | CCND1 | NA |
| PSMA2 | 1.70e-01 | peptidase | NA | NA | 4.0e-02 | CCND2 | NA |
| MED21 | -2.00e-02 | transcription regulator | NA | NA | 4.0e-02 | TNFAIP3 | NA |
| GLCCI1 | 7.00e-02 | other | NA | NA | 4.0e-02 | BCL2L11 | NA |
| PMS2 | NA | enzyme | NA | NA | 4.0e-02 | CCND1 | NA |
| XPO7 | -4.30e-01 | transporter | NA | NA | 4.0e-02 | CDKN1A | NA |
| CNTNAP2 | 2.10e-01 | other | NA | NA | 4.0e-02 | ATP2B2 | NA |
| ING3 | 1.40e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| TAOK3 | -5.40e-01 | kinase | NA | NA | 4.0e-02 | MX1 | NA |
| ceritinib | NA | chemical drug | NA | NA | 4.0e-02 | CD274 | NA |
| HOXB6 | 2.00e-02 | transcription regulator | NA | NA | 4.0e-02 | REN | NA |
| MAP3K20 | 2.00e-02 | kinase | NA | NA | 4.0e-02 | SOX6 | NA |
| JADE1 | -1.40e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| M6PR | -1.10e-01 | transporter | NA | NA | 4.0e-02 | NPC1 | NA |
| serelaxin | NA | biologic drug | NA | NA | 4.0e-02 | TGFB1 | NA |
| CDK20 | -4.30e-01 | kinase | NA | NA | 4.0e-02 | CCND1 | NA |
| ATP6V1B1 | 0.00e+00 | transporter | NA | NA | 4.0e-02 | ATP6V1B2 | NA |
| GDF10 | 1.60e-01 | growth factor | NA | NA | 4.0e-02 | SERPINE1 | NA |
| LNCRNA-IUR | NA | other | NA | NA | 4.0e-02 | TFRC | NA |
| SMAD9 | -5.40e-01 | transcription regulator | NA | NA | 4.0e-02 | ALPL | NA |
| PTOV1 | -1.30e-01 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| direct black 38 | NA | chemical reagent | NA | NA | 4.0e-02 | TFRC | NA |
| UBE2E1 | 2.00e-01 | enzyme | NA | NA | 4.0e-02 | CDKN1A | NA |
| CUL9 | -1.00e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| SCML2 | 2.90e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| DNAH5 | NA | enzyme | NA | NA | 4.0e-02 | DNAH6 | NA |
| Flt1 | -1.10e-01 | kinase | NA | NA | 4.0e-02 | ATF3 | NA |
| VWA8 | NA | enzyme | NA | NA | 4.0e-02 | THRB | NA |
| VAMP1 | NA | transporter | NA | NA | 4.0e-02 | CD274 | NA |
| PTMS | NA | other | NA | NA | 4.0e-02 | TAT | NA |
| DFFA | 3.30e-01 | enzyme | NA | NA | 4.0e-02 | DFFB | NA |
| TDP-665759 | NA | chemical reagent | NA | NA | 4.0e-02 | CDKN1A | NA |
| PSAT1 | 8.20e-01 | enzyme | NA | NA | 4.0e-02 | IRF1 | NA |
| TUBG1 | -1.40e-01 | other | NA | NA | 4.0e-02 | RB1 | NA |
| PSMD6 | 5.00e-02 | enzyme | NA | NA | 4.0e-02 | CCND2 | NA |
| UNC 0642 | NA | chemical reagent | NA | NA | 4.0e-02 | MAP1LC3B | NA |
| RPLP0 | -2.00e-02 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| HADHB | 2.00e-01 | enzyme | NA | NA | 4.0e-02 | REN | NA |
| pamiparib | NA | chemical drug | NA | NA | 4.0e-02 | CD274 | NA |
| levamlodipine | NA | chemical drug | NA | NA | 4.0e-02 | CD274 | NA |
| MKC-3946 | NA | chemical reagent | NA | NA | 4.0e-02 | XBP1 | NA |
| ASP5878 | NA | chemical drug | NA | NA | 4.0e-02 | CPT1A | NA |
| astragalus saponin | NA | chemical reagent | NA | NA | 4.0e-02 | XBP1 | NA |
| renin-angiotensin-aldosterone system blocking agent | NA | chemical drug | NA | NA | 4.0e-02 | AGT | NA |
| lithocholic acid acetate | NA | chemical reagent | NA | NA | 4.0e-02 | CYP7A1 | NA |
| fluticasone/salmeterol | NA | chemical drug | NA | NA | 4.0e-02 | CD274 | NA |
| 3-mercaptopicolinic acid | NA | chemical drug | NA | NA | 4.0e-02 | NR3C1 | NA |
| impromidine | NA | chemical drug | NA | NA | 4.0e-02 | LDLR | NA |
| phenidone | NA | chemical drug | NA | NA | 4.0e-02 | REN | NA |
| diisopropanolnitrosamine | NA | chemical toxicant | NA | NA | 4.0e-02 | CDKN1A | NA |
| dihydrotetrabenazine | NA | chemical drug | NA | NA | 4.0e-02 | TGFB1 | NA |
| sulfaphenazole | NA | chemical drug | NA | NA | 4.0e-02 | CCND1 | NA |
| remikiren | NA | chemical drug | NA | NA | 4.0e-02 | AGT | NA |
| bestatin | NA | chemical drug | NA | NA | 4.0e-02 | NOX4 | NA |
| Ro 20-1724 | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1 | NA |
| BTG3-AS1 | NA | other | NA | NA | 4.0e-02 | ATF3 | NA |
| daclizumab | NA | biologic drug | NA | NA | 4.0e-02 | MAF | NA |
| phytosphingosine | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CLDN1 | NA |
| NSC 126405 | NA | chemical reagent | NA | NA | 4.0e-02 | CDKN1A | NA |
| FL3 | NA | chemical reagent | NA | NA | 4.0e-02 | CD274 | NA |
| PF-06821497 | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L11 | NA |
| triazolam | NA | chemical drug | NA | NA | 4.0e-02 | PER1 | NA |
| sodium 2-((6Z,15Z)-20-hydroxyicosa-6,15-dienamido)acetate | NA | chemical reagent | NA | NA | 4.0e-02 | AGT | NA |
| naftifine | NA | chemical drug | NA | NA | 4.0e-02 | SQLE | NA |
| anti-miR-302d | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1 | NA |
| anti-miR-302c inhibitor | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1 | NA |
| rhapontin | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | FASN | NA |
| beta-penta-O-galloyl-glucose | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | CCND1 | NA |
| sodium hypochlorite | NA | chemical drug | NA | NA | 4.0e-02 | APEX1 | NA |
| CIC-DUX4 | NA | fusion gene/product | NA | NA | 4.0e-02 | DUSP6 | NA |
| FGFR3-TACC3 | NA | fusion gene/product | NA | NA | 4.0e-02 | PPARGC1A | NA |
| BV02 | NA | chemical reagent | NA | NA | 4.0e-02 | MAT1A | NA |
| STAT3 inhibitor | NA | chemical drug | NA | NA | 4.0e-02 | CD274 | NA |
| SMER3 | NA | chemical reagent | NA | NA | 4.0e-02 | PFKFB3 | NA |
| GTF2I-RARA | NA | fusion gene/product | NA | NA | 4.0e-02 | RNF8 | NA |
| miR-454-3p inhibitor | NA | chemical reagent | NA | NA | 4.0e-02 | STAT3 | NA |
| miR-140 inhibitor | NA | chemical reagent | NA | NA | 4.0e-02 | CD274 | NA |
| anti-miR-142 inhibitor | NA | chemical reagent | NA | NA | 4.0e-02 | CD274 | NA |
| miR-340 inhibitor | NA | chemical reagent | NA | NA | 4.0e-02 | CD274 | NA |
| miR-383 inhibitor | NA | chemical reagent | NA | NA | 4.0e-02 | CD274 | NA |
| miR-454-3p mimic | NA | chemical reagent | NA | NA | 4.0e-02 | STAT3 | NA |
| hP872 | NA | chemical reagent | NA | NA | 4.0e-02 | PCSK9 | NA |
| MIND4-17 | NA | chemical reagent | NA | NA | 4.0e-02 | GCLM | NA |
| CC-90009 | NA | chemical drug | NA | NA | 4.0e-02 | ATF3 | NA |
| cilengitide | NA | biologic drug | NA | NA | 4.0e-02 | CD274 | NA |
| chymostatin | NA | chemical - protease inhibitor | NA | NA | 4.0e-02 | AGT | NA |
| NCB-0846 | NA | chemical drug | NA | NA | 4.0e-02 | JUN | NA |
| polyphosphate 65 | NA | chemical reagent | NA | NA | 4.0e-02 | NLRP3 | NA |
| SMAD3-EP300 | NA | complex | NA | NA | 4.0e-02 | SERPINE1 | NA |
| teneligliptin | NA | chemical drug | NA | NA | 4.0e-02 | NOX4 | NA |
| TEI-F00806 | NA | chemical - protease inhibitor | NA | NA | 4.0e-02 | AGT | NA |
| berberrubine | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | LDLR | NA |
| columbamine | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | LDLR | NA |
| 2-methoxy-5-(2’,3’,4’-trimethoxyphenyl)-2,4,6-cycloheptatrien-1-one | NA | chemical reagent | NA | NA | 4.0e-02 | JUN | NA |
| AG 879 | NA | chemical drug | NA | NA | 4.0e-02 | RB1 | NA |
| 10-hydroxydecanoic acid | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | IRF1 | NA |
| agar | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | RBM3 | NA |
| dihydroxyacetone | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | NR3C1 | NA |
| miR-424-5p inhibitor | NA | chemical reagent | NA | NA | 4.0e-02 | WEE1 | NA |
| dexamethasone 21-methanesulfonate | NA | chemical reagent | NA | NA | 4.0e-02 | TAT | NA |
| NSC 228155 | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1 | NA |
| NACHR | NA | group | NA | NA | 4.0e-02 | CCND1 | NA |
| 3,5-L-diiodothyronine | NA | chemical - endogenous mammalian | NA | NA | 5.0e-02 | CPT1A,CYP7A1 | NA |
| L-phenylalanine | NA | chemical - endogenous mammalian | NA | NA | 5.0e-02 | FAS,IGFBP1 | NA |
| pyrophosphate | NA | chemical - endogenous mammalian | NA | NA | 5.0e-02 | ALPL,ANKH | NA |
| N-Cadherin | NA | group | NA | NA | 5.0e-02 | CCND1,CDKN1A | NA |
| GCS-100 | NA | chemical drug | NA | NA | 5.0e-02 | CCND2,CDKN1A | NA |
| HCFC1 | 8.00e-02 | transcription regulator | NA | NA | 5.0e-02 | FASN,PPARGC1B | NA |
| rhodamine 6G | NA | chemical toxicant | NA | NA | 5.0e-02 | CCND1,CCNE1 | NA |
| CENPN | -3.40e-01 | other | NA | NA | 5.0e-02 | PFKFB2,PFKFB3 | NA |
| Cyclin A | NA | group | NA | NA | 5.0e-02 | CDKN1A,PCYT1A | NA |
| LINC00461 | NA | other | NA | NA | 5.0e-02 | CCND1,TMEM161B | NA |
| 1,3-bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole | NA | chemical reagent | NA | NA | 5.0e-02 | CCND1,PLA2G4A | NA |
| VTCN1 | 4.80e-01 | other | NA | NA | 5.0e-02 | CCND1,CCNE1 | NA |
| CHCHD5 | -3.00e-02 | other | NA | NA | 5.0e-02 | FASN,PPARGC1A | NA |
| SLC2A11 | NA | transporter | NA | NA | 5.0e-02 | PPARGC1A,PPARGC1B | NA |
| TRPC4AP | -4.00e-02 | transporter | NA | NA | 5.0e-02 | NOLC1,NOP56 | NA |
| SLC2A10 | 1.60e-01 | transporter | NA | NA | 5.0e-02 | PPARGC1A,PPARGC1B | NA |
| LTBP4 | 5.00e-02 | growth factor | NA | NA | 5.0e-02 | ID2,TGFB1 | NA |
| Proinsulin | NA | group | NA | NA | 5.0e-02 | FOXO1,GCK | NA |
| BAG6 | 7.00e-02 | enzyme | NA | NA | 5.0e-02 | CDKN1A,SERPINE1 | NA |
| NFE2L3 | 6.30e-01 | transcription regulator | NA | NA | 5.0e-02 | CDKN1A,IL33 | NA |
| mir-190 | NA | microRNA | NA | NA | 5.0e-02 | CCND1,CLDN1 | NA |
| miR-217-5p (and other miRNAs w/seed ACUGCAU) | NA | mature microRNA | NA | NA | 5.0e-02 | FASN,PPARGC1A | NA |
| POU3F3 | -2.00e-01 | transcription regulator | NA | NA | 5.0e-02 | FABP7,PTGER3 | NA |
| EGR4 | NA | transcription regulator | NA | NA | 5.0e-02 | CREM,CYP17A1 | NA |
| CYP4A11 | 4.90e-01 | enzyme | NA | NA | 5.0e-02 | AGT,SLC12A3 | NA |
| MYH10 | -3.70e-01 | enzyme | NA | NA | 5.0e-02 | PPL,TGM1 | NA |
| ANK3 | 1.60e-01 | other | NA | NA | 5.0e-02 | GDF15,KLHDC7A | NA |
| AATF | 1.10e-01 | transcription regulator | NA | NA | 5.0e-02 | CDKN1A,JUN | NA |
| APCS | -1.00e-01 | other | NA | NA | 5.0e-02 | LDLR,SIRPA | NA |
| LPA | NA | other | NA | NA | 5.0e-02 | NR3C1,SERPINE1 | NA |
| PSMC3IP | 1.20e-01 | transcription regulator | NA | NA | 5.0e-02 | CEBPB,CYP17A1 | NA |
| CUL1 | 3.70e-01 | enzyme | NA | NA | 5.0e-02 | CCND2,CCNE1 | NA |
| SUPT5H | 1.90e-01 | transcription regulator | NA | NA | 5.0e-02 | CDKN1A,MEIS2 | NA |
| DENR | 1.80e-01 | other | NA | NA | 5.0e-02 | CD274,STAT3 | NA |
| BMP5 | -2.10e-01 | growth factor | NA | NA | 5.0e-02 | CCND2,CYP17A1 | NA |
| PIWIL2 | -2.10e-01 | enzyme | NA | NA | 5.0e-02 | CCND1,STAT3 | NA |
| LINC01612 | NA | other | NA | NA | 5.0e-02 | ATF3,CDKN1A | NA |
| SMARCD1 | 2.80e-01 | transcription regulator | NA | NA | 5.0e-02 | BTG2,CDKN1A | NA |
| filgotinib | NA | chemical drug | NA | NA | 5.0e-02 | MX1,Mx2 | NA |
| RACGAP1 | 1.80e-01 | transporter | NA | NA | 5.0e-02 | CDKN1A,JUN | NA |
| RHOC | 8.00e-02 | enzyme | NA | NA | 5.0e-02 | ATF3,CDKN1A | NA |
| PCBP1 | -1.00e-02 | translation regulator | NA | NA | 5.0e-02 | HNRNPD,INHBA | NA |
| GW 5074 | NA | chemical drug | NA | NA | 5.0e-02 | FGFR2,SERPINE1 | NA |
| PQQ cofactor | NA | chemical - endogenous non-mammalian | NA | NA | 5.0e-02 | NFE2L2,PPARGC1A | NA |
| CHS-828 | NA | chemical drug | NA | NA | 5.0e-02 | CD274,LRIG1 | NA |
| vandetanib | NA | chemical drug | NA | NA | 5.0e-02 | CCND1,CCNE1 | NA |
| Pi3k class I | NA | complex | NA | NA | 5.0e-02 | CHKA,FASN | NA |
| carnosol | NA | chemical - endogenous non-mammalian | NA | NA | 5.0e-02 | GCLM,NFE2L2 | NA |
| 2,4-dinitrophenol | NA | chemical toxicant | NA | NA | 5.0e-02 | PPARGC1A,PPARGC1B | NA |
| dexamethasone/INS/isobutylmethylxanthine | NA | chemical reagent | NA | NA | 5.0e-02 | CEBPB,FASN | NA |
| artemisinin | NA | chemical drug | NA | NA | 5.0e-02 | CCND1,CDKN1A | NA |
| sulfo-N-succinimidyl oleate | NA | chemical toxicant | NA | NA | 5.0e-02 | NLRP3,TLR6 | NA |
| TBP | -3.00e-02 | transcription regulator | NA | NA | 5.0e-02 | ASNS,CDKN1A,EDNRA,LDLR,MEOX2,PPP2R2B,TNFAIP3 | NA |
Liver %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S11. Ingenuity upstream regulators predicted to have similar activatory or inhibitory effect to ozone in Liver - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))read_excel("../input_files/Upstream/Adipose_upstream analysis.xls") %>% row_to_names(row_number=1) -> Adipose## New names:
## • `` -> `...2`
## • `` -> `...3`
## • `` -> `...4`
## • `` -> `...5`
## • `` -> `...6`
## • `` -> `...7`
## • `` -> `...8`as.numeric(Adipose$`Activation z-score`) -> Adipose$`Activation z-score`
Adipose <- Adipose[order(-Adipose$`Activation z-score`),]
as.numeric(Adipose$`Expr Log Ratio`) -> Adipose$`Expr Log Ratio`
as.numeric(Adipose$`p-value of overlap`) -> Adipose$`p-value of overlap`
Adipose %>%
mutate(
`Expr Log Ratio`=format(round(`Expr Log Ratio`,2),nsmall=2,scientific=TRUE),
`Activation z-score`=format(round(`Activation z-score`,2),nsmall=2,scientific=TRUE),
`p-value of overlap`=format(round(`p-value of overlap`,2),nsmall=2,scientific=TRUE)) %>%
kable(caption = "Supplementary Table S8. Ingenuity upstream regulators predicted to have similar activatory or inhibitory effect to ozone in Adipose", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(1:8,bold=ifelse(is.na(Adipose$`Predicted Activation State`),F,T),color= ifelse(is.na(Adipose$`Predicted Activation State`),"gray",ifelse(Adipose$`Predicted Activation State` == "Inhibited","#40004B","#00441B"))) %>%
scroll_box(width = "1200px", height = "500px")| Upstream Regulator | Expr Log Ratio | Molecule Type | Predicted Activation State | Activation z-score | p-value of overlap | Target Molecules in Dataset | Mechanistic Network |
|---|---|---|---|---|---|---|---|
| methylprednisolone | NA | chemical drug | Activated | 5.31e+00 | 0.0e+00 | APEX1,ARL4A,ASPA,BTG1,CBLB,CCL4,CCND1,CD180,CD22,CD38,CDKN1A,CYLD,DDIT4,Ddx3x,ECE1,EDNRB,EPHX2,FGL2,FGR,GADD45A,GBP2,GNL3,IDH1,IL1RN,IL6R,IRF1,JUN,LOX,LRP3,LYVE1,MDFIC,Mt1,MYC,NFKB2,NFKBIA,NR3C1,PCYT1A,PDE3B,PELO,PIK3AP1,PIK3CB,RAPGEF4,RELB,RND3,SDC4,SERPINE1,SGK1,SIRPA,SLC12A7,SLC16A1,SLC19A1,SLC25A30,SLC4A11,TFRC,TINAGL1,TLR2,TNK2,TOB1,TOMM20,Tsc22d3,TYRO3,UBE2G2,VMP1,ZFP36 | 412 (16) |
| dexamethasone | NA | chemical drug | Activated | 5.25e+00 | 0.0e+00 | AACS,ACLY,ADAMTS1,ADAMTS15,ADRB3,AGT,Akr1c14,APLN,ATF4,AXIN2,BCL2,BCL2L1,BCLAF1,BHLHE40,BIRC3,BMPR2,BNIP3,BTG1,BTG2,C9orf72,CBLB,CCL4,CCND1,CD22,CD38,CD83,CDKN1A,CDKN2C,CEBPD,CEP70,CFLAR,CIDEC,CISH,CMKLR1,COL7A1,CRHR2,CRISPLD2,CRP,CSF2RB,CX3CL1,CX3CR1,CXCL10,CYP2B6,CYSLTR1,DBT,DDHD1,DDIT4,EDEM1,EDNRA,EDNRB,EGLN3,EPAS1,ERRFI1,FAM107A,FANCA,FANCG,FGD4,FGF10,FGF2,FGL2,FKBP5,FLT3LG,FMO1,FOXO1,FOXO3,FTL,GADD45A,GAL,GATA6,GBP2,GBP5,GDF5,GFOD2,GLUL,GPR34,GRAMD4,H6PD,HK2,HPGD,HSD11B1,HSD11B2,HUNK,IDH1,IFRD1,IGFBP4,IL1R2,IL1RN,IL2RB,IL6R,INHBB,IRF1,IRS1,IRS2,ITGA1,ITGB7,JAK3,JARID2,JUN,KDR,KLF4,KLF6,LEP,LGALS3,LIMK1,LOX,LPIN2,LTB4R,LYVE1,MAFF,MAP3K5,MAPK6,MBIP,MEGF9,MERTK,MRC1,Mt1,MYC,MYO10,NFATC1,NFIL3,NFKB2,NFKBIA,NFKBIZ,NOD1,NR3C1,NUCB2,P4HA1,PARP16,Pcsk1,PCSK5,PDE4D,PDK4,PENK,PER1,PER3,PISD,PLEK,PLK2,PPARD,PPARG,PRDX6,RANBP9,RAPGEF4,RASD1,RELB,RGS16,RNF43,ROCK2,RORA,S100A10,SAMHD1,SAT1,SEMA6A,SERPINE1,SGK1,SH3TC1,SLC10A6,SLC25A33,SLC26A6,SLC2A5,SLC46A3,SLC4A11,SLC7A6,SPHK1,SPSB1,SREBF1,SSBP3,STAR,STAT5A,STX1A,SYBU,SYNC,TFRC,TGM2,THBS1,TLR2,TPH1,TRAF1,TRERF1,TSC22D1,Tsc22d3,VDR,VMP1,WNT5A,ZBTB16,ZFP36,ZNF189,ZNF385D,ZNF395,ZNF467 | 496 (18) |
| NR3C1 | -7.30e-01 | ligand-dependent nuclear receptor | Activated | 3.59e+00 | 0.0e+00 | ADH1C,ADRA1D,AGT,ARID4B,BCL2,BCL2L1,BHLHE40,BIRC3,BRAF,BTG1,C1QTNF1,CARD14,CCL4,CCND1,CD38,CD83,CDKN1A,CEBPD,CIDEC,COQ8A,CSRNP1,CX3CR1,CXCL10,DBT,DDIT4,ERRFI1,FADD,FGD4,FKBP5,FOXO1,FOXO3,GADD45A,GBP2,GLP2R,GLUL,GRIA2,H6PD,HSD11B1,HSD11B2,IDH1,IRF1,JUN,LEP,LOX,MFSD2A,Mt1,Mt1m/Mt2A,MYC,NAMPT,NFATC1,NFIL3,NFKB2,NFKBIA,NR3C1,PER1,PIK3CB,PLAGL1,PLK2,PPARG,RAPGEF4,RASD1,SERPINE1,SGK1,SLC25A33,SLC2A5,SLC7A6,STAT5A,THBS1,TIPARP,TLE3,TLR2,TRAF1,TRAF4,TRAF5,TRIM45,VDR,WNT5A | 473 (21) |
| corticosterone | NA | chemical - endogenous mammalian | Activated | 3.59e+00 | 0.0e+00 | ABCA6,BCL2,CCND1,CDKN1A,CRISPLD2,DBP,DDIT4,FGF2,FKBP5,GLUL,GPAM,HIF3A,HSD11B1,IRS1,JUN,LEP,MFSD2A,MYC,NR3C1,NR3C2,PDK4,PPARG,SGK1,SLC12A3,TGM2,TLR2,Tsc22d3 | 406 (25) |
| aldosterone | NA | chemical - endogenous mammalian | Activated | 3.53e+00 | 0.0e+00 | ADAMTS1,AGT,APLN,FKBP5,HAS2,IRS1,IRS2,KDR,LEP,LGALS3,LOX,NFKBIA,NR3C1,NR3C2,PER1,PGF,PPARG,SERPINE1,SGK1,SLC12A3,ZBTB16 | 414 (21) |
| IL10RA | 3.20e-01 | transmembrane receptor | Activated | 3.31e+00 | 0.0e+00 | ADH1C,Akr1c14,BATF2,BCL2,BNIP3,CBS/LOC102724560,CD300LF,CSF3R,CSRP2,DDHD1,DDIT4,EDNRB,FADS3,GBP2,GBP5,H2-T22,HPGD,HTR7,Ifi47,IKBKE,IL1RN,IRF1,Irgm1,ITGB7,NAMPT,NOD1,PPT2,SAMHD1,ST3GAL6,TAP1,TGM2,TLR2,UPP1 | 297 (12) |
| EIF2AK3 | 3.40e-01 | kinase | Activated | 3.24e+00 | 0.0e+00 | ATF4,BIRC3,BTG2,CCND1,EDEM1,FGF2,GADD45A,JUN,KLF4,MTHFR,MYC,NDRG1,NFIL3,NFKB2,RELB,SEC24D,SLC7A1,ZFP36 | 382 (21) |
| RNASEH2B | 1.00e-01 | other | Activated | 3.21e+00 | 0.0e+00 | ATAT1,CDKN1A,CPTP,CXCL10,DHX58,IFI44L,Igtp,IRF1,MOV10,NFKB2,OAS2,PYCARD,TAP1,TRIM14,UBA7 | NA |
| Ttc39aos1 | NA | other | Activated | 3.19e+00 | 0.0e+00 | CCL4,CXCL10,DHX58,DTX3L,GBP2,Igtp,IRF1,MOV10,OAS2,PYCARD,SERPINE1,SLC15A3,TAP1,ZNFX1 | 254 (7) |
| diclofenac | NA | chemical drug | Activated | 3.18e+00 | 0.0e+00 | ATF4,BACH1,CCND1,CDKN1A,CRP,EIF4A1,HPGD,JUN,KLF4,LBH,LGALS3,MED13L,MTHFD2,MYC,PIK3C2A,SERPINE1,SLC16A1,SLC7A1 | 333 (20) |
| dexamethasone phosphate | NA | chemical drug | Activated | 3.15e+00 | 0.0e+00 | DDIT4,ERRFI1,GADD45G,LYVE1,Mt1,NFKBIA,PDK4,SGK1,THBS1,TIPARP | 308 (7) |
| TGFB1 | -3.60e-01 | growth factor | Activated | 3.07e+00 | 0.0e+00 | ACLY,ACVR1,ADAM19,ADGRG2,ADORA1,ADRA1D,ALOX12,AMD1,APLN,APLNR,ARHGAP27,ARL4A,ATF4,ATG7,AXIN2,BCL2,BCL2L1,BCL9,BFAR,BHLHE40,BIRC3,BMPR2,BTG1,CALML3,CCL24,CCL4,CCND1,CD83,CDKN1A,CDKN2C,CEBPD,CIDEC,COL12A1,COL7A1,COX5A,CRHR2,CRP,CSRP2,CUL5,CX3CL1,CX3CR1,CXCL10,DBP,DDIT4,DTX4,ECE1,EDNRA,EDNRB,EIF2S2,ELK3,ESRP2,FAM107A,FAM53B,FGF10,FGF2,FGFR2,FOXO1,FOXO3,FSCN1,FTL,FZD8,GADD45A,GAL,GBP2,GLUL,GPR19,H6PD,HAS2,HAS3,HK2,HPGD,IDH1,IFRD1,IGFBP4,IL1RN,IL2RB,IL6R,INHBB,IRAK2,IRF1,IRS1,IRS2,ITGA1,ITGA11,ITGAL,ITGB7,JUN,KCNG1,KDR,KLF4,LEP,LGALS3,LOX,LYVE1,MAPK6,MBNL2,MET,MITF,MRC1,MST1R,MTHFD2,MYBL1,MYC,MYO10,NAMPT,NFATC1,NFKB2,NFKBIA,NOG,NRP1,NT5E,NUAK1,NUCB2,OGG1,OVOL1,P4HA1,PDE4A,PDE4D,PDE7A,PI4K2B,PIP5K1B,PLAGL1,PLK2,PML,POLD1,PPARD,PPARG,PPP1R13B,PPP2R2A,PROM1,PYCARD,RASGEF1B,RBM3,ROCK2,RORA,S100A10,SAMHD1,SDC4,SERPINE1,SGK1,SKIL,SLC12A7,SLC3A2,SLC7A1,SLC7A5,SMAD7,SMURF1,SPHK1,SQLE,SRFBP1,SRR,ST3GAL6,STAR,STAT5A,TBX3,TCF7L2,TFRC,TGM2,THBS1,TLL1,TLR2,TRAF1,TRIM2,TSC22D1,TTC28,TYW3,UST,VDR,VIP,WNT5A,XYLT1,ZFP36,ZFPM2 | 456 (16) |
| TRIM24 | NA | transcription regulator | Activated | 3.01e+00 | 0.0e+00 | CCL4,CXCL10,DHX58,FLRT3,GBP2,GBP4,GLUL,Ifi47,Igtp,IRF1,Irgm1,LGALS3,MOV10,PACSIN3,SAMHD1,SERPINE1,TAP1,TLR2,UBA7 | 282 (11) |
| TREX1 | -1.30e-01 | enzyme | Activated | 2.93e+00 | 0.0e+00 | CDKN1A,CPTP,CXCL10,DHX58,DTX3L,GBP4,GBP5,IFI44L,IKBKE,IRF1,MOV10,NAMPT,NFKB2,OAS2,PML,RASSF4,SAMHD1,TAP1,TRIM14,UBA7 | 225 (15) |
| HGF | 2.10e-01 | growth factor | Activated | 2.92e+00 | 0.0e+00 | ADAMTS1,ARRDC3,BCL2,BCL2L1,BIRC3,CCL4,CCND1,CDKN1A,CDKN2C,CFLAR,CHD2,CRY1,CYP2B6,EPHA4,ERRFI1,FANCG,FKBP5,GMNN,GPSM2,HDAC5,HK2,HTR7,IGFBP4,JUN,KLF6,LYVE1,MAS1,MERTK,MET,MPHOSPH10,MYC,NAMPT,NFATC1,NFKBIZ,NRP1,ORC2,PGF,PIK3CB,PLXNA2,PPARD,PPP2R2A,PTPRR,RCC1,RGS20,SERPINE1,SGK1,SKIL,SLC7A1,THBS1,TRIB1,VDR,ZFP36 | 446 (23) |
| NUPR1 | 4.90e-01 | transcription regulator | Activated | 2.91e+00 | 0.0e+00 | ABL2,ANK1,BCL9,BLM,BNIP3,BTG1,CCDC134,CHTF8,COQ10A,DAGLA,ELL2,ETV6,FHL2,FOXO3,FZD8,GAB2,GADD45A,GBP2,GPCPD1,GPSM2,HK2,IL6R,IRS2,KLF4,KLF6,LHFPL2,MEGF9,MYC,NCKIPSD,NDRG1,NEMP1,NFIL3,NR1D1,NRROS,NUCKS1,PER3,PRND,PXDC1,RCL1,RELB,RNFT2,SAMHD1,SAT1,SERPINE1,SLC16A10,SLC6A6,TOB1,TRERF1,TRIB1,UPP1,WDCP,XRCC2,ZFAND2A | 306 (7) |
| Irgm1 | -7.00e-01 | other | Activated | 2.90e+00 | 0.0e+00 | CXCL10,DHX58,DTL,GBP2,GBP4,GBP5,IRF1,OAS2,Oasl2,SAMHD1,TLR2,TRIM14 | 344 (17) |
| Tgf beta | NA | group | Activated | 2.88e+00 | 0.0e+00 | ADH1C,ARID4B,BACH1,BCL2,BCL2L1,BHLHE40,BNIP3,CCL4,CCND1,CDKN1A,CFLAR,COL12A1,COL7A1,COQ8A,CSF3,CX3CR1,CXCL10,CXCL17,EN1,EPAS1,FGF10,FGF2,FSCN1,HIF3A,IGFBP4,IL1RN,ITGA1,JARID2,JUN,LOX,Madcam1,MAFK,MERTK,MET,MITF,MMP15,MYC,PROM1,RORA,SERPINE1,SGK1,SKIL,SMAD7,SREBF1,SSBP3,TCF3,TFEB,TFRC,THBS1,TLR2,TMEM252 | 422 (19) |
| IL10 | -3.10e-01 | cytokine | Activated | 2.87e+00 | 0.0e+00 | ABCA6,BCL2,BCL2L1,CA12,CCL4,CD83,CDKN1A,CFLAR,CSF2RB,CSF3,CSF3R,CX3CR1,CXCL10,CXCL11,FKBP5,HPGD,IGFBP4,Igtp,IL1R2,IL1RN,IRF1,ITGAL,ITGB7,JUN,MERTK,MRC1,NFATC1,NT5E,PIK3CB,PIK3CG,PLEK,RGS16,SLC7A5,TAP1,TFRC,TINAGL1,TLR2,TRAF6,WEE1,ZFP36 | 419 (17) |
| PGR | 1.70e-01 | ligand-dependent nuclear receptor | Activated | 2.86e+00 | 0.0e+00 | ADAM19,ADAMTS1,ADARB1,ALDH1A3,AMD1,AMIGO1,BCL2L1,BIRC3,BTG1,CA12,CCND1,CDC42EP2,CDKN1A,CEBPD,COL12A1,COL7A1,CREB3L2,EDNRA,ELL2,EPAS1,FGF2,FKBP5,FLRT3,FOXO1,GAL,GLUL,HAS3,HDC,HPGD,HSD11B2,IFI44L,IRS1,IRS2,ITGA1,ITGA11,KCNG1,KLF4,LIMK1,LOX,MPHOSPH10,MPZL2,MYC,MYO10,NDRG1,NFKBIA,NRP1,OAS2,OGG1,PIP5K1B,PISD,PLK2,POLD1,PPARG,RND3,SERPINE1,SGK1,SLC7A5,SNAP25,STAT5A,TIPARP,TLL1,TRAF5,VDR | 491 (22) |
| EPHA2 | -3.50e-01 | kinase | Activated | 2.83e+00 | 0.0e+00 | ARRDC3,BCL2,FGF2,JUN,KLF6,NFKBIZ,SGK1,ZFP36 | 356 (18) |
| PPRC1 | 1.40e-01 | transcription regulator | Activated | 2.83e+00 | 0.0e+00 | ATF4,DDIT4,ERRFI1,HK2,NAMPT,NFKBIZ,RND3,VIP | NA |
| CLEC4A | -3.80e-01 | transmembrane receptor | Activated | 2.83e+00 | 0.0e+00 | APOBEC1,BHLHE40,CD83,HPGD,LYVE1,MRC1,STAT5A,TLR2 | 351 (12) |
| dalfampridine | NA | chemical drug | Activated | 2.80e+00 | 0.0e+00 | BTG2,GADD45G,GRIA2,HK2,JUN,KLF4,MAFF,TIPARP | 266 (13) |
| bicuculline | NA | chemical - endogenous non-mammalian | Activated | 2.79e+00 | 0.0e+00 | BTG2,GADD45G,GRIA2,HK2,JUN,KLF4,MAFF,TIPARP | 318 (19) |
| Insulin | NA | group | Activated | 2.74e+00 | 0.0e+00 | ACLY,ADH1C,ADRB3,AGT,AGTR1,APLN,APLNR,ARRDC3,ATG7,BCL2,BCL2L1,BMPR2,CCL4,CCND1,CDKN1A,CEBPD,CFLAR,CIDEC,DDIT4,EPAS1,ERRFI1,FGF2,FGFR4,FOXO1,FOXO3,FTL,HAP1,HIF3A,HK2,HSD11B1,HSD11B2,IDH1,IGFBP4,IMPDH2,IRS1,IRS2,ITGA1,JUN,KLF4,LEP,Mt1,MYC,NFIL3,NFKBIA,NR3C1,NUCB2,PDK4,PER1,PPARD,PPARG,PRDX6,PTPN11,PYCARD,ROCK2,SERPINE1,SGK1,SLC25A27,SLC2A5,SLC7A1,SMAD7,SNAP25,SQLE,SREBF1,STAR,STAT5A,TCF7L2,THBS1,TLR2,TPO,TTF2 | 434 (20) |
| thioacetamide | NA | chemical toxicant | Activated | 2.73e+00 | 0.0e+00 | AACS,ADAMTS1,BHLHE40,BIRC3,BLM,CIDEC,CSRP2,Ctla2a,EDNRB,FGFR3,JUN,KDR,LGALS3,LOX,LRAT,LYVE1,MBD4,MET,MYC,PROM1,RBM3,S100A10,SCN1B,SMAD7,TGM2,Tsc22d3,TYRO3,UPP1,WNT5A | 432 (15) |
| sodium arsenite | NA | chemical drug | Activated | 2.72e+00 | 0.0e+00 | BCL2,CBS/LOC102724560,CCND1,CDKN1A,CISH,EPAS1,FKBP5,GADD45A,HK2,JUN,MTHFR,PPARG | 425 (20) |
| HMG20A | -6.00e-02 | transcription regulator | Activated | 2.67e+00 | 0.0e+00 | CX3CL1,CXCL10,ERRFI1,FDPS,FGF2,GADD45A,IGFBP4,JUN,MYC,NT5E,RGS16,SDC4,SERPINE1,SLC7A1,SPHK1,SQLE,TGM2 | 250 (13) |
| tetrabromobisphenol A | NA | chemical toxicant | Activated | 2.65e+00 | 1.0e-02 | COL12A1,ITGA1,JUN,LOX,MYC,SMAD7,THBS1 | NA |
| ETV6-RUNX1 | NA | fusion gene/product | Activated | 2.63e+00 | 0.0e+00 | ARHGAP4,CARD11,CD83,CDC42EP2,CORO1A,CXXC5,CYSLTR1,DDIT4,EIF4A1,GBP2,GNA15,IRF1,ITGAL,JAK3,KLF6,MYC,OAS2,PAG1,PIK3C2B,PML,PROM1,RAP1GAP2,RELB,RGS16,SAMHD1,SEMA6A,SIPA1,SMAD7,SMIM3,TAX1BP1,TCF7L2,TDRD1,TFEB,TNK2 | NA |
| PTTG1 | 5.00e-02 | transcription regulator | Activated | 2.58e+00 | 0.0e+00 | APEX1,BCL2,CCND1,CDKN1A,CEBPD,FANCG,FGF2,MBD4,MYC,NPRL3,POLD1,XRCC6 | 409 (22) |
| MAPKAPK2 | 1.70e-01 | kinase | Activated | 2.56e+00 | 0.0e+00 | CEBPD,CXCL10,HDC,HSPB8,MKNK1,MRC1,NFKBIA,STAT5A,TSC22D1,ZFP36 | 389 (20) |
| YBX1 | -1.60e-01 | transcription regulator | Activated | 2.56e+00 | 1.0e-02 | BCL2,BCL2L1,CDKN1A,CIRBP,DCLK3,FGF2,GABPB1,KLF4,LGALS3,MKNK1,MYC,PLXNA2,TRIM14 | 336 (20) |
| forskolin | NA | chemical toxicant | Activated | 2.53e+00 | 0.0e+00 | ADAMTS1,AGTR1,AXIN2,BCL2,BHLHE40,BTG2,CCND1,CD8A,CDKN1A,CEBPD,CGREF1,CIDEC,CRISPLD2,CXCL10,DDIT4,DUSP9,EGLN3,ELL2,EPHA4,ERRFI1,FGFR2,FKBP5,FOXO1,GAB2,GADD45A,GADD45G,GAL,H3-3A/H3-3B,HAS2,HAS3,HK2,HPGD,HRH3,HSD11B1,HSD11B2,INHBB,IRS2,ITGA1,JAK3,JUN,KLF4,LEP,MAP3K5,MET,MFSD2A,MITF,Mt1,MYC,NAMPT,NFIL3,NFKBIA,NT5E,PDE4A,PDE4D,PDK4,PENK,PER1,PHKA2,PI4K2A,PLAGL1,PLK2,Ppp1r15a,RAB27A,RASGEF1B,S100A10,SAT1,SEMA6D,SERPINE1,SGK1,SLC2A5,SLC7A8,SMAD7,SMIM3,SNAP25,SOX17,STAR,TCF3,THBS1,TLE3,TP53I11,TPO,TRIB1,TTF2,UPP1,VDR,VIP | 365 (21) |
| SN-011 | NA | chemical reagent | Activated | 2.53e+00 | 0.0e+00 | CDKN1A,CXCL10,DTX3L,GBP4,GBP5,IKBKE,IRF1,MOV10,NAMPT,OAS2,PML,RASSF4,SAMHD1,TAP1,TRIM14,UBA7 | NA |
| FGF2 | 1.22e+00 | growth factor | Activated | 2.52e+00 | 0.0e+00 | ATF4,AXIN2,BCL2,BCL2L1,BNIP3,BTG2,CCND1,CDKN1A,CFLAR,CIDEC,CSF3,EDNRB,EGLN3,EPAS1,EPHA4,ERRFI1,FGF2,FGFR2,FGFR3,FGFR4,FOXO1,FOXO3,GADD45A,GAL,GATA6,GRB7,HAS2,HK2,HRH3,IGFBP4,IRS1,ITGA1,JUN,KDR,LOX,LYVE1,MET,MITF,MYC,NOG,NR3C1,NR3C2,PENK,PGF,PLK2,PPARG,RORA,S100A10,SEMA6D,SERPINE1,SMIM3,SOX17,SPHK1,STAR,THBS1,TPO,WNT5A,XRCC6 | 420 (21) |
| progesterone | NA | chemical - endogenous mammalian | Activated | 2.49e+00 | 0.0e+00 | ADAMTS1,ADARB1,ADCYAP1R1,AGTR1,AMD1,ARL4A,BCL2,BCL2L1,BHLHE40,BIRC3,C9orf72,CA12,CCND1,CDKN1A,CEBPD,CIDEC,COL12A1,CREB3L2,CSF3R,CX3CL1,CXCL10,CXCL11,CYP2B6,DBP,EDNRA,ELL2,EPAS1,ERRFI1,FGFR2,FKBP5,FMO5,FOXO1,FRAT2,GAL,GPAM,HDC,HSD11B1,HSD11B2,HUNK,IL6R,IRS1,IRS2,ITGA1,ITGA11,JUN,KCNG1,KDR,LGALS3,MPHOSPH10,MRC1,MYC,MYO10,NDRG1,NFIL3,NFKBIA,NOD1,NR1D1,NR3C2,NRP1,PIP5K1B,PISD,PLIN4,PLK2,PPARG,PTGER1,PYCARD,SGK1,SPHK1,SPSB1,SREBF1,STAT5A,TCF7L2,THBS1,TIPARP,TRAF5,VDR,Wdr86 | 431 (24) |
| calcitriol | NA | chemical drug | Activated | 2.48e+00 | 0.0e+00 | ADAM19,AFAP1L2,BACH1,BCL2,BCL2L1,CCND1,CD38,CDKN1A,CEBPD,CISH,CXCL10,CYP2B6,DACT2,ERRFI1,FAM107A,FDPS,FGFR3,FOXO3,FTL,GADD45A,GADD45G,GATA6,HK2,HPGD,HSPB7,IDH1,IFI44L,IKBKE,IL1RN,ITGB7,JUN,KCNH1,KLF4,LBH,LEP,LRTM2,MFSD2A,MRC1,MYC,NFATC1,NFKB2,NFKBIA,PDE4D,PDK4,PDLIM2,PIK3AP1,PISD,PPARD,PPARG,PTPRR,RELB,SLC16A1,SMAD7,SREBF1,TAP1,TCF3,THBS1,TINAGL1,TLR2,TP53INP1,VDR,WEE1 | 370 (20) |
| STAG2 | 2.20e-01 | other | Activated | 2.45e+00 | 1.0e-02 | BATF2,CXCL10,CXCL11,DHX58,GBP2,IFI44L | NA |
| nicotinamide-beta-riboside | NA | chemical - endogenous mammalian | Activated | 2.45e+00 | 3.0e-02 | CCL4,COX5A,CXCL10,FMO3,HPGD,RDH16 | NA |
| tetrachlorodibenzodioxin | NA | chemical toxicant | Activated | 2.44e+00 | 0.0e+00 | ALDH1A3,ATF4,BACH2,BCL2,BMPR2,BTG1,CAPN9,CCND1,CDKN1A,DACT2,DCLK3,FMO2,FMO3,HDAC5,HUNK,IDH1,INPP5A,IRF1,IRS1,ITGAL,ITGB7,JUN,MMP15,MYC,MYO10,NR3C1,PLAGL1,PLXNA2,RDH16,SAT1,SERPINE1,SLC12A7,SLC16A10,SLC7A5,STAR,THBS1,TIPARP,TULP2 | 384 (24) |
| STAT3 | -1.00e-01 | transcription regulator | Activated | 2.43e+00 | 0.0e+00 | AGT,ALDH1A3,APEX1,APLN,BCAR3,BCL2,BCL2L1,CCL4,CCND1,CD83,CDKN1A,CDON,CEBPD,CEP70,CFLAR,CHL1,CRP,CSF3,CX3CL1,CXCL10,DDIT4,EPAS1,FGF2,FGL2,FLRT3,FSCN1,GADD45A,GADD45G,GBP2,GBP5,HAS2,HK2,Igtp,IKBKE,IL1RN,IL2RB,IL6R,IRF1,Irgm1,KCTD11,KDR,KLF4,LEP,LOX,MGST2,MITF,Mt1,MYC,NAMPT,NDRG1,NFATC1,NFIL3,NFKB2,NFKBIZ,NRP1,NRP2,NT5E,OAS2,OSBPL5,PLAGL1,Pmaip1,PML,PRF1,PROM1,RAB27A,RALGDS,RNLS,RORA,SDC4,SEMA6D,SERPINE1,SGK1,SLC16A1,SLC2A5,SMAD7,SREBF1,TAP1,TGM2,THBS1,TOB1,TRIM14,VIP,WNT5A,ZFP36 | 428 (15) |
| Wy 40905 | NA | chemical reagent | Activated | 2.42e+00 | 0.0e+00 | BTG2,CDKN1A,JUN,KLF4,KLF6,NFKBIZ,PER1,RASD1,SCN1B,SERPINE1,SKIL,ZFP36 | 382 (20) |
| USP8 | 2.00e-02 | peptidase | Activated | 2.42e+00 | 3.0e-02 | CXCL10,Irgm1,MET,NOD1,OAS2,Oasl2,TAP1 | NA |
| AMBRA1 | 1.90e-01 | other | Activated | 2.42e+00 | 2.0e-02 | CCND1,CDKN1A,ITGB7,MMP15,SERPINE1,SMAD7 | NA |
| carbamazepine | NA | chemical drug | Activated | 2.42e+00 | 0.0e+00 | ATF4,BACH1,BCL2,CYP2B6,EIF4A1,HDAC5,MED13L,MTHFD2,PIK3C2A,SLC7A1 | 151 (7) |
| betamethasone | NA | chemical drug | Activated | 2.41e+00 | 0.0e+00 | ASPA,CRISPLD2,HIF3A,KDR,NR3C1,TGM2 | NA |
| ELK1 | 1.10e-01 | transcription regulator | Activated | 2.41e+00 | 1.0e-02 | BCL2L1,BMPR2,CDKN1A,JUN,MTHFD2,THBS1,TIPARP,TPO,ZFP36 | 360 (14) |
| RASSF1 | 1.60e-01 | other | Activated | 2.41e+00 | 0.0e+00 | BCL2,BHLHE40,BMPR2,CCND1,CDKN1A,FGF2,KLF4,LDB2,MAP3K5,MYC,NOG,PLK2,PROM1,SAMD5,TGM2,TP53INP1 | 368 (23) |
| ETS2 | -1.00e-01 | transcription regulator | Activated | 2.39e+00 | 1.1e-01 | BCL2L1,CDKN1A,CSF3,HPGD,JUN,MYC | NA |
| cadmium chloride | NA | chemical toxicant | Activated | 2.37e+00 | 0.0e+00 | ATF4,CCND1,CRP,FKBP5,FOXO1,GADD45A,HK2,HSPB8,JUN,MAFF,Mt1,MYC | 391 (21) |
| fluticasone propionate | NA | chemical drug | Activated | 2.33e+00 | 0.0e+00 | CD83,CRP,CXCL10,DDIT4,FKBP5,FSCN1,GAL,GAPT,GBP5,HPGD,HSD11B1,IL1R2,IL1RN,IRS2,ITGB7,MDFIC,MERTK,NAMPT,OAS2,PDK4,SDC4,SERPINE1,SLC2A5,TAP1,TGM2,THBS1,TSC22D1 | 408 (15) |
| streptozocin | NA | chemical drug | Activated | 2.32e+00 | 0.0e+00 | APLN,ATF4,BCL2,BCL2L1,CBS/LOC102724560,CDKN1A,CIDEC,COL12A1,FGFR4,HSD11B2,IRS1,IRS2,LEP,LGALS3,MC5R,NR3C2,NT5E,Pcsk1,PDK4,Pmaip1,PPARD,PPARG,SERPINE1,SLC12A3,SLC2A5,SLC7A8,SREBF1,TCF7L2,TRPC3 | 428 (22) |
| glucocorticoid | NA | chemical drug | Activated | 2.32e+00 | 0.0e+00 | ACE2,ADRB3,AGT,APLN,BCL2,CDKN1A,CEBPD,CRY1,CSF3,CYP2B6,DBP,GLUL,HAS2,IL1R2,IL1RN,IL6R,JAK3,LEP,Mt1,MYC,NFKBIA,NOD1,NR3C1,PER1,PER3,PPARG,RASD1,SERPINE1,SGK1,TBC1D15,TLR2,VDR,ZBTB16 | 391 (18) |
| deferoxamine | NA | chemical drug | Activated | 2.29e+00 | 0.0e+00 | APLN,BACH1,BCL2,BHLHE40,BNIP3,CCL4,CCND1,CDKN1A,CFLAR,EGLN3,EPAS1,ERRFI1,GADD45A,HK2,IGFBP4,ITGB7,JUN,LEP,MYC,NDRG1,NFIL3,NFKB2,PIP5K1B,PPARG,PROM1,SERPINE1,SMAD7,SREBF1,TFRC,TSC22D1,VDR | 438 (23) |
| SMAD4 | 1.90e-01 | transcription regulator | Activated | 2.29e+00 | 0.0e+00 | ACVR1,CCL24,CCND1,CDKN1A,COL7A1,ETV6,FGFR3,FSCN1,GADD45A,HAS2,ITGB7,MET,MST1R,MYC,NAMPT,NFKBIA,OVOL1,SERPINE1,SGK1,SKIL,SMAD7,SPHK1,STAR,TBX3,THBS1,VIP,ZFP36 | 421 (20) |
| PRKAA | NA | group | Activated | 2.29e+00 | 0.0e+00 | BCL2,CCND1,CDKN1A,CXCL10,FKBP5,FOXO3,HSD11B1,OGG1,SREBF1,STAR,TMPRSS2 | 373 (21) |
| CCN2 | NA | growth factor | Activated | 2.28e+00 | 0.0e+00 | ADAMTS1,BCL2,BCL2L1,CCND1,CFLAR,EGLN3,ITGA1,JUN,LOX,MBNL2,MYC,P4HA1,PDE7A,PI4K2B,SDC4,SERPINE1 | 428 (21) |
| prostaglandin E2 | NA | chemical - endogenous mammalian | Activated | 2.27e+00 | 0.0e+00 | ADAMTS1,Akr1c14,BCL2,BCL2L1,BIRC3,BTG1,CCL4,CCND1,CD83,CDKN1A,CEBPD,CSF3,CXCL10,FGF2,FOXO1,FSCN1,GBP5,HAS2,HDC,IGFBP4,IL1R2,IL1RN,IRF1,JAK3,JUN,KLF4,LOX,MITF,MRC1,MYC,NFIL3,NFKBIA,NFKBIZ,NOD1,NRP1,NT5E,PDE4A,PENK,PGF,PIK3CG,PKN1,PLK2,PPARG,PROM1,PYCARD,RASGEF1B,RELB,SPHK1,STAR,TCF7L2,TFRC,THBS1,TSC22D1,XRCC6 | 445 (19) |
| Vegf | NA | group | Activated | 2.26e+00 | 0.0e+00 | ADAMTS1,Akr1c14,APLN,APLNR,AXIN2,BCL2,C1QTNF1,CDKN2C,CFLAR,CRY1,CXCL10,CXCL11,DENND2D,EPHA4,FANCG,FGF2,FKBP5,GMNN,GPSM2,HDC,HK2,HTR7,IGFBP4,INHBB,IRF1,JUN,KDR,KIAA1671,LEP,LRAT,LRIG1,LYVE1,MET,MGST2,MPHOSPH10,MYC,NAMPT,NFATC1,NRARP,NRP1,NRROS,PDK4,PGF,PIK3CB,PIK3CG,PLXNA2,PPARD,PTPRR,RCC1,RGS20,SGK1,SLC7A1,TRAF5,TRIB1 | 355 (25) |
| FOXA2 | NA | transcription regulator | Activated | 2.26e+00 | 0.0e+00 | ADH1C,Akr1c14,CCL24,CCND1,DDIT4,EN1,FOXO1,GAL,HK2,HPGD,Mt1,NFKB2,PPARG,RORA,SLC10A6,SOX17,SPSB1,STAT5A,TMPRSS2,UST,WNT5A | 423 (24) |
| IRGM | NA | enzyme | Activated | 2.25e+00 | 0.0e+00 | CXCL10,DHX58,GBP4,IFI44L,IKBKE,MAP3K6,NFKBIA,OAS2,SAMHD1,TRIM14,UBA7 | 198 (8) |
| SFN | 2.60e-01 | other | Activated | 2.24e+00 | 1.0e-02 | AMOT,BTG2,FKBP5,PDK4,SGK1 | 181 (7) |
| HOXC8 | -2.90e-01 | transcription regulator | Activated | 2.24e+00 | 2.0e-02 | ADAM19,CXCL10,GREM2,IL1R2,PLAGL1 | NA |
| CYP27B1 | -4.00e-01 | enzyme | Activated | 2.24e+00 | 4.0e-02 | BCL2,CCL4,CCND1,TLR2,VDR | NA |
| estriol | NA | chemical - endogenous mammalian | Activated | 2.24e+00 | 4.0e-02 | CCL4,CXCL10,IL1RN,IRS1,IRS2 | NA |
| ACKR2 | -4.50e-01 | G-protein coupled receptor | Activated | 2.24e+00 | 6.0e-02 | CXCL10,DHX58,Ifi47,OAS2,Oasl2 | NA |
| tributyltin | NA | chemical reagent | Activated | 2.23e+00 | 0.0e+00 | ACLY,BMPR2,CIDEC,IDH1,ITGB7,LEP,MITF,PDK4,PLIN4,PPARG,ROCK2,SREBF1,THBS1,ZNF423 | 303 (16) |
| RC3H1 | NA | enzyme | Activated | 2.22e+00 | 4.0e-02 | CCL24,CCL4,IFI44L,IRF1,NRP1,OAS2,WNT5A | NA |
| BMP10 | 7.00e-02 | growth factor | Activated | 2.21e+00 | 0.0e+00 | ALDH1A3,ALOX12,APLN,BMPR2,CCNT1,CD83,COL12A1,CX3CR1,FGF2,FGFR2,FGL2,HPGD,ITGAL,NFKBIA,SKIL,SMAD7,THBS1 | 174 (7) |
| NR1I3 | -6.00e-02 | ligand-dependent nuclear receptor | Activated | 2.21e+00 | 1.0e-02 | CDKN1A,CYP2B6,ENKD1,MAFF,Mt1,MYC,PDE3B,PTPN11,SAT1,SREBF1,TMPRSS2 | 416 (17) |
| NGLY1 | -3.00e-02 | enzyme | Activated | 2.21e+00 | 2.0e-02 | BNIP3,CXCL10,GABPB1,IFI44L,TAX1BP1 | NA |
| ATF4 | 8.20e-01 | transcription regulator | Activated | 2.20e+00 | 0.0e+00 | APEX1,ATF4,BTG1,CDKN1A,DDIT4,EIF2S2,GADD45A,JUN,KLF4,LGALS3,MED13L,MITF,MTHFD2,NDRG1,PENK,Pmaip1,PPARG,SLC3A2,SLC6A9,SLC7A1,SLC7A5,SREBF1 | 321 (22) |
| TP63 | -2.60e-01 | transcription regulator | Activated | 2.19e+00 | 0.0e+00 | ADAMTS1,ALDH1A3,ALOX12,APOBEC1,ATG7,BCL2L1,BHLHE40,BLM,BRAF,CAPN9,CCND1,CCNT1,CDK18,CDKN1A,CFLAR,CXCL17,DDIT4,FANCA,FDPS,FGF11,FGFR2,FGFR3,FOXO3,FSCN1,FZD8,GADD45A,GAL,GCNT3,HAS3,HIP1R,HK2,IFT74,IKBKE,JAK3,JUN,KCNG1,KLF4,KLF6,MAFF,MLPH,MPZL2,MYC,NT5E,Pmaip1,RASA3,RASSF4,RCC1,RELB,SERPINE1,SMAD7,ST8SIA6,STX1A,SUFU,TCF7L2,THBS1,TINAGL1,TP53INP1,TPO,TRAF1,TRAF4,VDR,VMP1,WEE1,WNT5A | 402 (18) |
| PDGF BB | NA | complex | Activated | 2.19e+00 | 0.0e+00 | ADARB1,ADRA1D,Akr1c14,BHLHE40,CCND1,CDKN1A,CEBPD,COL12A1,CSF3,CSRP2,EDNRB,FGF2,FHL2,FMO1,GADD45A,GBP2,GJA5,GLUL,IGFBP4,JUN,KLF6,LGALS3,MAFK,MAP3K4,MGST2,Mt1,MYC,NAMPT,NFIL3,PLK2,PPARD,PPARG,RND3,SAT1,SERPINE1,SGK1,SKIL,SLC6A6,SLC7A1,SPHK1,SREBF1,TGM2,THBS1,TOB1,TRIB1,TRIOBP,UCK1,ZFP36 | 389 (17) |
| USP19 | 1.00e-02 | peptidase | Activated | 2.18e+00 | 0.0e+00 | BIRC3,BNIP3,CBLB,CXCL10,DDIT4,FKBP5,FOXO3,NR3C1 | 183 (7) |
| MEN1 | -4.30e-01 | transcription regulator | Activated | 2.18e+00 | 0.0e+00 | CCND1,CDKN1A,CDKN2C,FKBP5,HOXC6,INHBB,IRS2,MYC | 358 (20) |
| PRLR | -1.70e-01 | transmembrane receptor | Activated | 2.18e+00 | 0.0e+00 | CDKN1A,CISH,FGF2,LEP,MYC,STAR,VDR | 346 (20) |
| 1-methyl-4-phenylpyridinium | NA | chemical toxicant | Activated | 2.17e+00 | 1.0e-02 | ATF4,BACH1,CCND1,DDIT4,TFRC | 328 (16) |
| NODAL | NA | growth factor | Activated | 2.17e+00 | 1.0e-02 | CCND1,CXCL10,FOXO3,MRC1,SOX17 | 426 (24) |
| PLA2G10 | NA | enzyme | Activated | 2.16e+00 | 4.3e-01 | CD8A,MRC1,STAR,TCF3,TRAF4 | NA |
| dibutyl phthalate | NA | chemical toxicant | Activated | 2.16e+00 | 1.0e-02 | INHBB,JUN,MYC,SERPINE1,STAR | 363 (23) |
| CD3E | -1.00e-02 | transmembrane receptor | Activated | 2.16e+00 | 0.0e+00 | BCL2L1,BLM,BNIP3,CBLB,CLSPN,JUN,MYC,NFATC1,NFKBIA,PIK3CG,SPHK1,WEE1,XRCC2 | 388 (21) |
| L-glutamic acid | NA | chemical - endogenous mammalian | Activated | 2.15e+00 | 0.0e+00 | ACLY,BCL2,BCL2L1,CCND1,CDKN1A,CIDEC,CYP2B6,FGF2,FMO2,GRIA2,JUN,LEP,MITF,NFIL3,PER1,ROCK2,SQLE,TAP1 | 361 (22) |
| NSUN6 | -4.00e-02 | enzyme | Activated | 2.12e+00 | 0.0e+00 | CDKN2C,FGF2,FSCN1,NDRG1,SERPINE1,SGK1,TGM2,THBS1 | NA |
| 2-bromoethylamine | NA | chemical reagent | Activated | 2.12e+00 | 0.0e+00 | ADAMTS1,Ctla2a,LGALS3,MRC1,MYC,RBM3,S100A10,UPP1 | NA |
| clopidogrel | NA | chemical drug | Activated | 2.12e+00 | 1.0e-02 | CHD2,CRP,GPT2,IFRD1,LURAP1L,MYC,RGS16,SLC3A2 | NA |
| E2F1 | -2.00e-01 | transcription regulator | Activated | 2.12e+00 | 0.0e+00 | ARHGAP4,ATG7,BCL2,BCL2L1,BCS1L,BNIP3,CCND1,CDKN1A,CDKN2C,CFLAR,CHEK2,COX5A,FGF2,FGFR2,FGFR3,FOXO1,FOXO3,GMNN,GRAMD4,HSD11B2,IRS1,IRS2,KCNH1,KDR,LEP,MAP3K5,MTBP,MYC,NFKBIA,NPAT,NRP1,PDK4,PLK2,Pmaip1,POLD1,PPARG,PPP1R13B,PPP1R26,PPT2,PTPN4,RANBP1,RND3,SERPINE1,SLC16A1,SLC3A2,STAM,TAP1,TCF3,THBS1,TP53INP1,WEE1,ZFP36 | 396 (21) |
| 1,2-dithiol-3-thione | NA | chemical reagent | Activated | 2.10e+00 | 1.0e+00 | BNIP3,ETV6,FKBP5,FMO1,NUCB2,PSMD8,SREBF1,TFRC | NA |
| acetaminophen | NA | chemical drug | Activated | 2.07e+00 | 0.0e+00 | ALOX12,APEX1,BCL2,BTG2,CCND1,CDKN1A,CRP,CXCL10,FTL,GADD45A,GLUL,Gulo,IDH1,IFRD1,IRS1,JUN,KDR,Mt1,MYC,PPARG,PRDX6 | 409 (19) |
| BSG | 8.00e-02 | transporter | Activated | 2.07e+00 | 1.0e-02 | BCL2L1,CCND1,CRP,EPAS1,KDR,SERPINE1,SLC16A1 | 361 (20) |
| IL6 | NA | cytokine | Activated | 2.06e+00 | 0.0e+00 | ACVR1,ADAMTS1,AGT,AXIN2,BCL2,BCL2L1,BTG2,CCL24,CCL4,CCND1,CD38,CD83,CDKN1A,CEBPD,CFLAR,CISH,CRP,CSF2RB,CSF3R,CX3CR1,CXCL10,CYP2B6,EGLN3,EPHA4,ERRFI1,FGF2,FSCN1,GADD45A,GADD45G,GAL,GBP2,HOMER3,HPGD,HRH3,IGFBP4,IKBKE,IL1RN,IL6R,IRF1,IRS1,ITGA1,JUN,KDR,LEP,MERTK,MET,Mt1,Mt1m/Mt2A,MYC,NAMPT,NFKBIA,NR3C1,NUCB2,PENK,PGF,PLEK,PLK2,POLD1,PPARG,PRF1,PROM1,RAB27A,RASA3,RORA,SEMA6D,SERPINE1,SGK1,SMAD7,SMIM3,TAP1,TFRC,TGM2,THBS1,TLR2,TRAF6,TYK2,VIP,WEE1,WNT5A | 430 (17) |
| metribolone | NA | chemical reagent | Activated | 2.06e+00 | 0.0e+00 | ACLY,ADAMTS1,ADH1C,ALDH1A3,ALDH9A1,APPBP2,BCL2,BCL2L1,CCND1,CDKN1A,CFLAR,COX5A,EDEM1,ELL2,ERRFI1,FDPS,FHL2,FKBP5,FLVCR2,FOXO1,FZD8,GADD45G,HK2,HUS1,INPP4B,IRS2,LRIG1,MAP7,MERTK,MYC,NDRG1,PDE4D,POLR3K,PRDX6,RAB27A,RGMA,RRP12,SAT1,SEC24D,SREBF1,THBS1,TMPRSS2,TOMM70,TSC22D1,WEE1 | 453 (22) |
| vancomycin | NA | biologic drug | Activated | 2.06e+00 | 1.0e-02 | A3GALT2,ADAMTS1,ATG7,BACH1,BIRC3,CCND1,Ctla2a,DAGLA,FMO2,LGALS3,MRC1,MYC,NUAK1,RBM3,S100A10,SLC7A8,ST3GAL6,UPP1 | 309 (15) |
| bortezomib | NA | chemical drug | Activated | 2.05e+00 | 0.0e+00 | ATF4,BCL2,BCL2L1,BIRC3,BNIP3,CCL4,CCND1,CDKN1A,CEBPD,CFLAR,CSF2RB,CXCL10,DCAF12,FANCA,FANCG,FOXO1,GADD45A,HSD11B2,IRS1,MAPK6,MITF,MYC,SREBF1,TRAF4 | 401 (23) |
| NFATC2 | -3.00e-01 | transcription regulator | Activated | 2.04e+00 | 0.0e+00 | BCL2L1,CD83,CDKN1A,CFLAR,CISH,CX3CL1,CX3CR1,CXCL10,FGL2,GBP4,GDF5,IRF1,JARID2,JUN,MERTK,MITF,MYC,NFATC1,NFKBIA,NFKBIZ,PLK2,PML,PPARG,RELB,SLC3A2,STAT5A,TLR2,TRAF1,TSC22D1 | 372 (14) |
| TGFA | -5.40e-01 | growth factor | Activated | 2.03e+00 | 0.0e+00 | BCL2L1,BIRC3,CCND1,CDKN1A,CXCL10,ERRFI1,IGFBP4,PLAGL1,S100A10,SERPINE1,WNT5A | 412 (22) |
| IL4 | NA | cytokine | Activated | 2.01e+00 | 0.0e+00 | ADAM19,ALOX12,ANKRD55,BCL2,BCL2L1,BHLHE40,BNIP3,CCL24,CCL4,CCND1,CD22,CD300LF,CD38,CD83,CD8A,CDKN1A,CFLAR,CISH,CITED1,CRISPLD2,CSF2RB,CSF3,CSF3R,CX3CL1,CXCL10,CXCL11,CYSLTR1,DDHD1,DDIT4,DHX58,EIF4A1,EPAS1,FFAR4,FKBP5,FLT3LG,FSCN1,GADD45G,GBP2,GBP5,GNA15,HDC,HK2,HPGD,HSD11B1,IFI44L,IGFBP4,Igtp,IL1R2,IL1RN,IL2RB,IRAK2,IRF1,Irgm1,ITGA1,ITGAL,ITGB7,JAK3,JUN,KCNG1,KCNH1,KLF4,KLF6,LGALS3,LPIN2,LTB4R,MAP3K5,MERTK,MFSD2A,MIF4GD,MOV10,MRC1,MYC,NDRG1,NFATC1,NFIL3,NFKB2,NFKBIA,NFKBIZ,NR3C1,NRP1,OAS2,PCYOX1L,PIK3C2B,PIP5K1B,PPARG,PRF1,PSTPIP1,RASGEF1B,RASSF4,RCC1,S100A10,SERPINE1,SIRPA,SLC25A25,Slc26a10,SLC7A5,SPHK1,SREBF1,STAT5A,TFRC,TGM2,TINAGL1,TLR2,TMED5,TMTC1,TP53I11,TRAF1,TRPV2,TYRO3,UPP1,VDR,VIPR2,XRCC6,ZFP36 | 424 (16) |
| Notch | NA | group | Activated | 2.01e+00 | 0.0e+00 | AGT,CD300LF,CDKN1A,CSF2RB,CSF3R,CXXC5,GAPT,IDH1,LTB4R,MET,MEX3B,MYC,NFATC1,NHSL2,PIK3AP1,SAMHD1,SMURF1,SRFBP1,TRAF4 | 364 (14) |
| sulforafan | NA | chemical drug | Activated | 2.01e+00 | 1.0e-02 | ADAMTS1,AGT,BCL2,BCL2L1,CCND1,CDKN1A,FTL,GABPB1,GATA6,IL6R,KDR,MED13L,MST1R,Mt1,MYO1E,NFKBIA,PLEKHH3,PML,STAR,TAX1BP1,TEAD1 | 362 (24) |
| chloroquine | NA | chemical drug | Activated | 2.00e+00 | 0.0e+00 | BCL2,BCL2L1,CD83,CXCL10,FOXO1,FOXO3,IRS1,MET,NT5E,SLC12A3,TRAF6 | 372 (19) |
| 17-alpha-ethinylestradiol | NA | chemical drug | Activated | 2.00e+00 | 1.0e-02 | ARRDC3,ATF4,CDKN1A,CXCL10,CYP2B6,EIF2S2,INHBB,INPP5A,JUN,MET,MRC1,SGK1,STAT5A,TGM2 | 481 (23) |
| Glucocorticoid-GCR | NA | complex | Activated | 2.00e+00 | 0.0e+00 | BCL2,IL1R2,MRC1,THBS1 | NA |
| oxymatrine | NA | chemical drug | Activated | 2.00e+00 | 2.0e-02 | BCL2,CYP2B6,SMAD7,SREBF1 | NA |
| SH3PXD2A-AS1 | NA | other | Activated | 2.00e+00 | 2.0e-02 | CX3CL1,MET,PROM1,SERPINE1 | NA |
| SH3TC2 | -4.50e-01 | other | Activated | 2.00e+00 | 4.0e-02 | AACS,ACLY,FDPS,SQLE | NA |
| CD276 | -2.80e-01 | other | Activated | 2.00e+00 | 4.0e-02 | CXCL10,CXCL11,IRF1,OAS2 | NA |
| CD83 | -6.50e-01 | transmembrane receptor | Activated | 2.00e+00 | 5.0e-02 | KLF4,MERTK,MRC1,NFATC1 | NA |
| SCARB1 | -1.80e-01 | transporter | Activated | 2.00e+00 | 6.0e-02 | CX3CL1,DDIT4,FOXO1,IL1RN,SREBF1 | NA |
| LILRB4 | -4.40e-01 | other | Activated | 2.00e+00 | 7.0e-02 | CD8A,CSF3R,CXCL10,CXCL11 | NA |
| etanercept | NA | biologic drug | Activated | 2.00e+00 | 9.0e-02 | CD83,CXCL10,FOXO3,NFATC1 | NA |
| 3,5-dihydroxyphenylglycine | NA | chemical reagent | Activated | 2.00e+00 | 1.0e+00 | CSMD2,GRIK3,RPL9,RPS18 | NA |
| JUND | -4.00e-02 | transcription regulator | NA | 1.99e+00 | 7.0e-02 | AGT,AGTR1,CCND1,CXCL10,HPGD,PENK,SAT1 | NA |
| GFPT1 | 6.00e-02 | enzyme | NA | 1.98e+00 | 0.0e+00 | HAS2,LEP,PPARG,THBS1 | 420 (22) |
| Fgf | NA | group | NA | 1.98e+00 | 0.0e+00 | CCND1,GNL3,JUN,KDR,MITF,PER1 | 373 (23) |
| PML-RARA | NA | fusion gene/product | NA | 1.98e+00 | 0.0e+00 | CDKN1A,CYTH4,FGR,JUN,MYC,S100A10 | 325 (12) |
| NBEAL2 | -1.50e-01 | other | NA | 1.98e+00 | 1.0e-02 | CCL4,CXCL10,MITF,THBS1 | 383 (18) |
| pirfenidone | NA | chemical drug | NA | 1.98e+00 | 4.0e-02 | CX3CR1,FOXO1,NR3C2,RND3 | NA |
| CD200 | -2.70e-01 | other | NA | 1.98e+00 | 2.0e-02 | ITGAL,MET,MRC1,TLR2 | NA |
| pitavastatin | NA | chemical drug | NA | 1.98e+00 | 5.0e-02 | FDPS,NFATC1,PPARG,SQLE | NA |
| thioctic acid | NA | chemical drug | NA | 1.97e+00 | 1.0e-02 | BCL2,JUN,LEP,MITF,MYC,PDK4,PPARD | NA |
| Ck2 | NA | complex | NA | 1.96e+00 | 0.0e+00 | ATF4,BCL2L1,MYC,ZFP36 | 415 (22) |
| MDL 73811 | NA | chemical reagent | NA | 1.96e+00 | 1.0e-02 | CDKN1A,LGALS3,SERPINE1,TGM2 | NA |
| TWIST2 | 3.00e-02 | transcription regulator | NA | 1.96e+00 | 1.6e-01 | CCND1,CDKN1A,KLF6,RNF43 | NA |
| Ck2 alpha | NA | group | NA | 1.96e+00 | 0.0e+00 | BCL2L1,BIRC3,CXCL10,MYC | 340 (19) |
| ATF3 | 3.70e-01 | transcription regulator | NA | 1.96e+00 | 0.0e+00 | AMPD2,ATF4,BIRC3,CCND1,CD83,CDKN1A,CX3CL1,GBP2,GBP4,IMPDH2,ITGA1,JUN,NFKB2,NFKBIZ,PENK,POLD1,SERPINE1,SLC15A3,TLR2 | 391 (17) |
| mevastatin | NA | chemical drug | NA | 1.95e+00 | 1.0e-02 | ADAMTS1,CDKN1A,KLF4,SREBF1 | 317 (10) |
| SOX17 | 8.10e-01 | transcription regulator | NA | 1.95e+00 | 2.0e-02 | AXIN2,CCND1,GATA6,KDR,PROM1 | NA |
| AAMDC | 9.00e-02 | other | NA | 1.95e+00 | 0.0e+00 | ATF4,CBS/LOC102724560,MTHFD1L,MYC | 88 (3) |
| ADCY | NA | group | NA | 1.95e+00 | 0.0e+00 | CDKN1A,FGF2,LEP,NFATC1,PER1 | 322 (23) |
| PTPN3 | -6.30e-01 | phosphatase | NA | 1.95e+00 | 0.0e+00 | CDKN1A,MYC,SERPINE1,SMAD7,TGM2,VDR | 370 (19) |
| allopurinol | NA | chemical drug | NA | 1.94e+00 | 0.0e+00 | A3GALT2,ADAMTS1,BIRC3,Ctla2a,CXCL10,LGALS3,MRC1,MYC,RBM3,S100A10,UPP1 | 349 (17) |
| GPER1 | -2.20e-01 | G-protein coupled receptor | NA | 1.94e+00 | 0.0e+00 | BHLHE40,CCND1,CDKN1A,CEBPD,DDIT4,ERRFI1,JUN,MYC,NFKBIA,RASD1,RGS16,ZFP36 | 492 (22) |
| PDLIM2 | 9.90e-01 | other | NA | 1.94e+00 | 1.1e-01 | BCL2,CCND1,CRISPLD2,FOXRED2,MPZL2,OBSL1,PDLIM2 | NA |
| FOXO4 | -1.40e-01 | transcription regulator | NA | 1.94e+00 | 0.0e+00 | ACLY,Akr1c14,APLN,BCL2L1,BNIP3,CCND1,CDKN1A,EDNRB,GADD45A,LRAT,NAMPT,NRP2,OVOL1,PTPRB,SERPINE1,SGK1 | 378 (19) |
| FGFR1 | -2.60e-01 | kinase | NA | 1.93e+00 | 0.0e+00 | CCND1,CDKN1A,CRISPLD2,FGF10,FGF2,FGFR3,FGFR4,HAS2,HK2,ITGA1,JUN,LOX,MYC | 348 (22) |
| THEM6 | -5.70e-01 | other | NA | 1.93e+00 | 6.0e-02 | ATF4,EDEM1,FDPS,SQLE | NA |
| MAPK14 | -2.70e-01 | kinase | NA | 1.92e+00 | 0.0e+00 | AXIN2,BCL2,BTG2,CCND1,CD83,CEBPD,CRP,CXCL10,FDPS,GADD45A,HAS2,HTR7,JUN,KDR,NFATC1,NRP1,Pmaip1,SGK1,SPHK1,SREBF1,TGM2,TLR2,VDR,VIP,ZFP36 | 437 (19) |
| IL6R | 7.40e-01 | transmembrane receptor | NA | 1.91e+00 | 4.0e-02 | BCL2L1,CDKN1A,CXCL10,GAL,IL6R,IRF1,NAMPT,PENK | NA |
| amphetamine | NA | chemical drug | NA | 1.91e+00 | 3.0e-02 | ATF4,BCL2,BCL2L1,CCNT1,FGF10,JUN,MYBL1,SGK1 | NA |
| atorvastatin | NA | chemical drug | NA | 1.91e+00 | 0.0e+00 | ACE2,BCL2,BCL2L1,CRP,CYP2B6,EDNRA,FDPS,GPAM,ITGAL,JUN,LEP,PPARG,SERPINE1,SQLE,TLR2,TMEM106A,TMEM267,USP49,ZFP36,ZNF786 | 348 (24) |
| norepinephrine | NA | chemical - endogenous mammalian | NA | 1.91e+00 | 0.0e+00 | ADRB3,ATP7B,Cbarp,COQ10B,CRY1,DCLK3,FGF2,GMNN,IRAK2,IRS2,LEP,NFKBIA,PDE4D,PER1,PLAGL1,PPARG,SERPINE1,SGK1,SMAD7,TFRC,TINAGL1 | 416 (22) |
| cobalt chloride | NA | chemical reagent | NA | 1.90e+00 | 0.0e+00 | ADAMTS1,BACH1,BCL2,BHLHE40,BNIP3,CDKN1A,DDIT4,EPAS1,HIF3A,HK2,HSD11B2,LEP,MITF,NDRG1,PROM1,SMAD7,SPHK1,TFRC | 407 (17) |
| carbonyl cyanide m-chlorophenyl hydrazone | NA | chemical toxicant | NA | 1.90e+00 | 0.0e+00 | AGT,ATF4,DDIT4,ERRFI1,HK2,NAMPT,NFKBIZ,RND3,SERPINE1,VIP | 376 (15) |
| ARNT2 | -5.00e-02 | transcription regulator | NA | 1.90e+00 | 4.1e-01 | CMKLR1,COL12A1,ELL2,GLUL,IGFBP4,IL6R,LDB2,Nat3,SLC12A3,TYK2 | NA |
| SP3 | -9.00e-02 | transcription regulator | NA | 1.90e+00 | 0.0e+00 | ALOX12,CBS/LOC102724560,CCND1,CDKN1A,CDKN2C,COL7A1,FGF10,HAS2,HSD11B2,IL2RB,JUN,KDR,KLF4,MET,PCYT1A,SERPINE1,SGK1,SLC19A1,SREBF1,TLR2,XYLT1 | 428 (24) |
| UM101 | NA | chemical drug | NA | 1.89e+00 | 0.0e+00 | CXCL10,CXCL11,GBP4,GPR88,HAS3,SLC15A3,VDR | NA |
| FLT1 | NA | kinase | NA | 1.89e+00 | 3.0e-02 | APLNR,CDKN1A,EPAS1,LIN7C,NRP1,NRP2,PREB,THBS1 | NA |
| RGS4 | -2.50e-01 | enzyme | NA | 1.89e+00 | 1.3e-01 | ABHD10,CRHR2,KDR,MBNL2,NRIP3,TFRC,VDR | NA |
| RAF1 | 2.00e-02 | kinase | NA | 1.89e+00 | 0.0e+00 | AMD1,BCL2,BTG1,CCND1,CDKN1A,CDON,CRP,FAM171A1,HDC,HSD11B2,JUN,MCF2L,MET,MYC,RND3,SQLE,TGM2,TRAF1,TSC22D1 | 345 (18) |
| IL1RN | -1.02e+00 | cytokine | NA | 1.88e+00 | 0.0e+00 | CDKN1A,CXCL11,CYLD,H6PD,HSD11B1,IFI44L,IGFBP4,IRF1,KLF6,OAS2,PML,SERPINE1,SLC15A3,STAR,TCF7L2 | 381 (15) |
| EGFR | 3.90e-01 | kinase | NA | 1.88e+00 | 0.0e+00 | ACVR1,AMD1,AXIN2,BCL2,BCL2L1,BTG1,CCND1,CDKN1A,CUL5,CXCL10,EDEM1,EIF4A1,EPS15,GADD45A,GALNT10,HAS2,HDC,HK2,HSD11B2,IGFBP4,IRF1,JUN,MET,MST1R,MTHFR,MYC,NFKBIA,NT5E,PIK3C2A,PRF1,PROM1,QTRT2,RANBP1,RCL1,RND3,SERPINE1,SLC25A32,SLC7A1,SLC7A5,SPHK1,Tchh,TFRC,TGM2,THBS1,VDR,WEE1 | 437 (21) |
| TNFRSF1B | 2.60e-01 | transmembrane receptor | NA | 1.87e+00 | 1.9e-01 | BCL2L1,CFLAR,JUN,LEP,SERPINE1,TRAF1,TRAF6 | NA |
| Mek | NA | group | NA | 1.86e+00 | 0.0e+00 | ACVR1,BCL2L1,CCND1,CDKN1A,CXCL10,CXCL11,EDEM1,EPAS1,GALNT10,GBP2,GNL3,HAS2,Ifi47,IRF1,JUN,KDR,LEP,MAFF,MST1R,MYC,NT5E,POMK,RND3,ROCK2,SEMA6A,SERPINE1,SLC7A1,THBS1 | 403 (22) |
| SRC | -5.00e-01 | kinase | NA | 1.86e+00 | 1.0e-02 | BCL2L1,CCND1,CDKN1A,CDON,CSF3,CXCL10,FGR,FMN2,HAS2,JUN,MYC,SIRPA | 354 (17) |
| REST | 5.40e-01 | transcription regulator | NA | 1.85e+00 | 1.0e-02 | ARRDC3,CMKLR1,CNTNAP1,GRIA2,GRIK3,HPGD,ITGAL,MYC,NRP1,PENK,RAB3A,SNAP25,STX1A,VIP | NA |
| ATM | 7.00e-02 | kinase | NA | 1.84e+00 | 0.0e+00 | BCL2L1,BLM,CCND1,CDKN1A,CFLAR,CHEK2,GADD45A,GADD45G,IRF1,JUN,LEP,SERPINE1,TGM2 | 384 (19) |
| triamterene | NA | chemical drug | NA | 1.84e+00 | 0.0e+00 | A3GALT2,ADAMTS1,BIRC3,Ctla2a,LGALS3,MRC1,MYC,RBM3,S100A10,UPP1 | NA |
| NRG1 | 5.00e-02 | growth factor | NA | 1.84e+00 | 0.0e+00 | ATF4,BCL2,BCL2L1,BNIP3,CCND1,CDKN1A,CDKN2C,ERRFI1,FGF2,FSCN1,GDF5,GRB7,HK2,HOXD3,JUN,MDFIC,MITF,MST1,MYC,NDRG1,PHKG1,RAB3A,SERPINE1,SGK1,TGM2,THBS1,VIP,XRCC6,ZFP36 | 403 (21) |
| YAP1 | NA | transcription regulator | NA | 1.83e+00 | 0.0e+00 | ACLY,ADAMTS1,ANK1,ARID4B,BCL2L1,CCND1,CDKN1A,CEP131,COL7A1,CSF3,DTX2,ENDOU,FDPS,GADD45A,IGFBP4,ITGA1,LOX,MRC1,MYC,NDRG1,NFKBIA,NRIP3,P4HA1,PDE3B,PDK4,RANBP1,RASSF4,RPL9,RPS18,SERPINE1,SGK1,SMAD7,STAR,STAT5A,TFRC,THBS1,TRAF6,UCK1 | 413 (21) |
| doxorubicin | NA | chemical drug | NA | 1.82e+00 | 0.0e+00 | A3GALT2,ADAMTS1,APEX1,ASAP3,ATG7,BCL2,BCL2L1,BHLHE40,BIRC3,BTG1,BTG2,CCND1,CDKN1A,CFLAR,CGREF1,CHEK2,Ctla2a,CXCL10,DDIT4,FGF10,FGF11,FOXO3,GADD45A,IGFBP4,IRF1,Irs3,JPH2,JUN,KLHL26,LGALS3,LIMA1,MBNL2,MET,MRC1,MYBL1,MYC,NDRG1,NFKBIA,NT5E,PIDD1,Pmaip1,RBM3,RGS16,S100A10,SAMHD1,SLC6A6,SMAD7,SPHK1,TAP1,TGM2,TP53INP1,UPP1,ZNF423 | 376 (19) |
| PDX1 | NA | transcription regulator | NA | 1.82e+00 | 0.0e+00 | ACE2,ATF4,CCND1,CX3CL1,FGF2,HAP1,IDH1,IRS2,JUN,KLF6,MITF,MPHOSPH10,Mt1,MYC,Pmaip1,SLC6A6,SSBP3,TCF7L2,TRPC3 | 420 (20) |
| N-acetylsphingosine | NA | chemical reagent | NA | 1.82e+00 | 0.0e+00 | BCL2,BCL2L1,BNIP3,CDKN1A,HSD11B1,JUN,MAP3K5,PDE3B,SERPINE1,SPHK1 | 319 (21) |
| levodopa | NA | chemical - endogenous mammalian | NA | 1.82e+00 | 0.0e+00 | ARHGAP4,BACH1,BCL2,BCL2L1,CA12,CCND1,CDC42EP2,CMTM8,CYLD,CYTH4,DBP,DIXDC1,ECE1,EDNRB,FAAP100,FADD,FDPS,FKBP5,FOXO1,FRAT2,FTL,GRIA2,HVCN1,Klf16,KLF6,LDB2,MBNL2,MEIS2,MFSD2A,MITF,NDUFA5,NRARP,NT5E,NUAK1,Oasl2,Pakap,PENK,PER1,PGM2L1,PIK3CG,PLEK,PLK2,PPP1R13B,PPP2R2A,RILP,S100A10,SBK1,SH3PXD2B,TRERF1,TRIOBP,TRPC3,VMP1 | 456 (24) |
| PIK3CG | -6.80e-01 | kinase | NA | 1.81e+00 | 0.0e+00 | BCL2,CD8A,CXCL10,GBP2,GBP4,GBP5,Igtp,IL2RB,IRF1,NFATC1,NOD1,OAS2,PIK3CG,PRF1,TAP1,TLR2 | 376 (17) |
| ursodeoxycholic acid | NA | chemical - endogenous mammalian | NA | 1.80e+00 | 0.0e+00 | BCL2L1,CX3CL1,CXCL10,CYP2B6,IRS1,LGALS3,NFKB2,SREBF1,VDR | 364 (18) |
| methyl methanesulfonate | NA | chemical toxicant | NA | 1.80e+00 | 0.0e+00 | ATF4,BTG1,BTG2,CDKN1A,GADD45A,GADD45G,JUN,KLF4,NUCB2,OGG1,Ppp1r15a,TP53INP1 | 377 (18) |
| fenamic acid | NA | chemical reagent | NA | 1.78e+00 | 0.0e+00 | A3GALT2,ADAMTS1,BIRC3,Ctla2a,LGALS3,MRC1,MYC,RBM3,S100A10,UPP1 | NA |
| ethanol | NA | chemical - endogenous mammalian | NA | 1.78e+00 | 0.0e+00 | ACLY,ADCYAP1R1,ADH1C,ALDH1A3,ATF4,AXIN2,BCL2,BCL2L1,CCND1,CDKN1A,CEBPD,CRP,CYP2B6,EDNRB,FGF2,GADD45A,GBP2,GPAM,GREM2,Ifi47,IL1R2,IL1RN,JUN,KLF4,KLF6,MYC,NR3C1,NT5E,PPARG,PRF1,PROM1,RORA,RRP12,SERPINE1,SGK1,SQLE,SREBF1,STAR,SYNPO2,TGM2,TLR2,TP53INP1,WEE1 | 422 (20) |
| RPTOR | 1.00e-02 | other | NA | 1.77e+00 | 0.0e+00 | BCL2,CCND1,FDPS,FGF2,HIGD1A,HK2,Ifi47,IRS1,JUN,MRC1,MYC,NR3C2,PTPN11,PYCARD,SQLE,SREBF1 | 432 (23) |
| gentamicin | NA | chemical drug | NA | 1.77e+00 | 0.0e+00 | APEX1,BACH1,BTG2,CBS/LOC102724560,CCND1,CSRP2,CXCL10,DAGLA,EPHX2,FMO1,GADD45A,GNL3,H3-3A/H3-3B,HSD11B2,IDH1,IFRD1,IRF1,JUN,KLF6,LGALS3,MAPK6,MYC,NR1D1,NUAK1,PELO,Ppp1r15a,Serbp1,SLC7A8,ST3GAL6,TAP1,TFRC,TSC22D1 | 236 (7) |
| Go 6976 | NA | chemical drug | NA | 1.76e+00 | 0.0e+00 | BCL2L1,CCL4,CCND1,CD83,CDKN1A,CSF3,CXCL10,HDAC5,NFKBIA,TRAF1 | 317 (13) |
| reactive oxygen species | NA | chemical toxicant | NA | 1.75e+00 | 0.0e+00 | APEX1,BCL2,BCL2L1,CDKN1A,CSF3,FGF2,FOXO3,GADD45A,JUN,KLF6,LEP,MYC,PPP2R2A,PRF1,SERPINE1,TLR2 | 377 (21) |
| isoproterenol | NA | chemical drug | NA | 1.75e+00 | 0.0e+00 | ADCY5,ADRB3,AGT,APLN,APLNR,ATP7B,BCL2,BVES,CSF3,FGF2,JUN,LEP,LGALS3,MERTK,MITF,NAMPT,PLAGL1,RAB27A,TYRO3 | 393 (20) |
| bleomycin | NA | biologic drug | NA | 1.74e+00 | 0.0e+00 | ACE2,ARRDC3,BCL2,BCL2L1,BHLHE40,BLM,BMPR2,CD300LF,CDKN1A,CSF2RB,CSF3,CXCL10,CYP2B6,GAB2,GADD45A,GPR34,IRS2,ITGA1,KLF4,LGALS3,LOX,MAFF,MAP3K6,MRC1,MYC,PLK2,RASD1,SDC4,SERPINE1,SIRPA,SPHK1,THBS1,TINAGL1,TLR2,TMPRSS2,WNT5A | 453 (19) |
| EHMT1 | 1.00e-02 | transcription regulator | NA | 1.73e+00 | 0.0e+00 | CD38,CDKN1A,CDKN2C,CEBPD,GRAMD4,HSD11B2,MEGF9,PISD,SAT1,SH3TC1,SLC4A11,SYBU,SYCE1,SYNC | 18 (2) |
| RLIM | 9.30e-01 | enzyme | NA | 1.73e+00 | 0.0e+00 | CDKN1A,SERPINE1,SKIL,SMAD7 | 131 (7) |
| SUMO3 | 2.00e-02 | other | NA | 1.73e+00 | 1.0e-02 | AGT,CD38,CXCL10,IRS1,PML,TAP1 | 323 (14) |
| gentamicin C | NA | chemical drug | NA | 1.73e+00 | 0.0e+00 | A3GALT2,ADAMTS1,BIRC3,Ctla2a,LGALS3,MRC1,MYC,RBM3,S100A10,UPP1 | NA |
| BCR (complex) | NA | complex | NA | 1.72e+00 | 0.0e+00 | BCL2,BCL2L1,CCL4,CCND1,CD22,CDKN1A,CFLAR,COX5A,FOXO1,GBP2,GNL3,HK2,IL1R2,IL2RB,KLF4,MPHOSPH10,MYC,NAMPT,NFKB2,NIP7,PDE7A,PLEK,RCL1,RRP12,S100A10,SEMA4B,SLC19A1,TRIB1,WDR43,ZBTB16 | 371 (22) |
| prexasertib | NA | chemical drug | NA | 1.72e+00 | 0.0e+00 | BIRC3,BTG2,CDKN1A,CSRNP1,KLF4,MYC,NFKBIA,PLK2,SERPINE1,SGK1,SKIL,TRAF1,ZFP36 | 392 (17) |
| EGF | 4.30e-01 | growth factor | NA | 1.72e+00 | 0.0e+00 | ADAMTS1,ALOX12,AMIGO1,BCL2,BCL2L1,BTG2,CCND1,CDKN1A,CEBPD,CFLAR,CISH,CYP2B6,EPAS1,EPS15,ERRFI1,FGD4,FGF2,GAB2,GADD45A,GAL,GATA6,GLUL,GRB7,HAS2,HAS3,HPGD,IDH1,IGFBP4,IL1R2,IRS1,JUN,KCTD11,MAP3K5,MET,MST1,MYC,NOG,NRP1,PDK4,PER1,PGF,PLAGL1,PPARD,PPARG,PROM1,S100A10,SEMA6A,SERPINE1,SMURF1,SNAP25,SOX17,SPHK1,SREBF1,STAR,TGM2,THBS1,TMEM88,TYK2,USP27X,VDR,VIP,XRCC6,ZFP36 | 497 (24) |
| PG3-Oc | NA | chemical reagent | NA | 1.72e+00 | 0.0e+00 | ATF4,CDKN1A,MET,NDRG1,PIDD1,TP53INP1 | NA |
| meclizine | NA | chemical drug | NA | 1.72e+00 | 0.0e+00 | CYP2B6,HK2,MYC,NAMPT | 278 (11) |
| H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one | NA | chemical reagent | NA | 1.72e+00 | 2.0e-02 | BNIP3,CD83,CD8A,CDKN1A | NA |
| CITED2 | 1.50e-01 | transcription regulator | NA | 1.71e+00 | 0.0e+00 | ARL4A,ASAP3,BCL2,BCL9,CXCL10,DTX3L,EGLN3,GATA6,GBP2,GBP4,GBP5,Ifi47,IFRD1,IL1RN,IRF1,Irgm1,KLF6,MAPK6,MED13,MRC1,NAMPT,Oasl2,OTUD1,SAT1,TGM2,UPP1 | 305 (13) |
| STAT4 | NA | transcription regulator | NA | 1.71e+00 | 0.0e+00 | ATF4,BANP,BCL2,BCL2L1,CIR1,CXCL10,ERRFI1,FSCN1,GADD45G,H3-3A/H3-3B,IRF1,Mt1,MYC,NDRG1,PER1,PRDX6,RASL12,RGS16,RORA,SAT1,SERPINE1 | 396 (18) |
| parthenolide | NA | chemical drug | NA | 1.71e+00 | 0.0e+00 | AXIN2,BCL2,BCL2L1,MITF,NR3C2,PDK4,TCF7L2 | 433 (27) |
| BMP4 | -2.90e-01 | growth factor | NA | 1.70e+00 | 0.0e+00 | BCL2,CCND1,CDKN1A,CSF3,CXXC5,FGFR2,HK2,INHBB,JUN,KDR,KLF4,MAFK,MITF,MYC,NOG,OVOL1,PGF,PPARD,PPARG,SERPINE1,SMAD7,SOX17,STAR,TBX3,TGM2,TRPV2,WNT5A | 362 (25) |
| di(2-ethylhexyl) phthalate | NA | chemical toxicant | NA | 1.70e+00 | 4.0e-02 | IRAK2,JUN,MYC,SREBF1,STAR,ZFP36 | NA |
| PTGER4 | -4.70e-01 | G-protein coupled receptor | NA | 1.69e+00 | 1.0e-02 | ARRDC3,CCL4,CXCL10,GBP2,GBP4,HAS2,Ifi47,Igtp,IRF1,Irgm1,LHFPL2,MAFF,STXBP4,TP53INP1 | 437 (19) |
| NR3C2 | -6.80e-01 | ligand-dependent nuclear receptor | NA | 1.69e+00 | 0.0e+00 | ADAMTS1,AGT,BCL2,BCL2L1,DDIT4,FGF2,FKBP5,KDR,NR3C1,NRIP3,PGF,PLIN4,RAPGEF4,SERPINE1,SGK1,SPHK1,TGM2 | 426 (20) |
| beta-estradiol | NA | chemical - endogenous mammalian | NA | 1.69e+00 | 0.0e+00 | ABCA5,ADAMTS1,ADGRG2,ADH1C,ADORA1,ADRA1A,ADRB3,AGT,AGTR1,ANK1,APEX1,ARL4A,BCL2,BCL2L1,BCS1L,BHLHE40,BIRC3,BMPR2,BTG1,BTG2,C1orf226,CA12,CBS/LOC102724560,CCL4,CCND1,CDK18,CDKN1A,CEBPD,CISH,CITED1,COL7A1,COX5A,CREB3L2,CRHR2,CRP,CSF2RB,CSF3R,CXCL10,CXCL11,CXXC4,CXXC5,CYP2B6,CYTH4,DBP,DDIT4,DLG3,EIF3A,ELK3,EPAS1,ERRFI1,ETFBKMT,ETV6,FADD,FADS3,FAM107A,FAM163B,Fbxl19,FGF2,FGFR2,FGFR3,FHL2,FLRT3,FMO1,FMO2,FMO5,FOXO1,FOXO3,FSCN1,FZD8,GAB2,GADD45A,GADD45G,GAL,GBP2,GDF5,GLUL,GNL3,GPAM,GPR88,GPSM2,GPT2,GRB7,GRIK3,H6PD,HAS2,HDAC5,HIGD1A,HOXC6,HPGD,HR,HRH3,HSD11B1,HSD11B2,HSPB8,HTR7,HUNK,IFRD1,IGFBP4,IL1R2,IL6R,IMPDH2,INHBB,INPP4B,IRF1,IRF6,IRS1,IRS2,ITGA1,ITGA11,JUN,KCND3,KDR,KLF4,KLF6,KLHL26,LEP,LGALS3,LHFPL2,LIMA1,LIMK1,LOX,LRIG1,MBD4,MDFIC,MEIS2,MERTK,MET,MOSPD2,MRAP2,MRC1,MYBL1,MYC,MYO10,NAMPT,NDRG1,NFKB2,NFKBIA,NOG,NR3C1,NR3C2,NRIP3,NRP1,NRP2,NUCB2,Oasl2,OSBPL5,OTUB2,P2RX5,P4HA1,Pakap,PDE3B,PDK4,PENK,PIK3C2A,PIK3C2B,PIP5K1B,PLAGL1,PLK2,PPARG,PREB,PRICKLE2,PROM1,PTPN11,PTPRB,RALGDS,RANBP1,RASD1,RASSF10,RBM15,RCL1,REEP1,RELB,RGS16,RLIM,RND3,RORA,RPL9,SAMHD1,SAT1,SBK1,SDC4,SERPINE1,SGK1,SKIL,SLC12A3,SLC12A7,SLC16A1,SLC25A25,SLC3A2,SLC6A9,SLC7A5,SLC7A8,SMAD7,SNAP25,SPHK1,SQLE,SREBF1,STAR,STAT5A,SUFU,SYBU,TFEB,TGM2,THBS1,TLR2,TNK2,TP53I11,TP53INP1,TPO,TRAF4,TRIB1,TRPC3,TRPV2,TSC22D1,TYK2,TYRO3,VAPA,VDR,VIPR2,WEE1,WNT5A,ZBTB16,ZFHX2,ZFP36,ZNF846 | 519 (21) |
| JUNB | 3.10e-01 | transcription regulator | NA | 1.68e+00 | 0.0e+00 | ACLY,AGTR1,CCND1,CFLAR,COL7A1,CSF3,EPAS1,HK2,HPGD,NAMPT,NFKB2,PENK,PPP2R2A,RELB,SERPINE1,SGK1,SLC7A1,STAR,TBX3 | 419 (22) |
| PTH | NA | other | NA | 1.68e+00 | 1.0e-02 | ADAMTS1,BCL2,BHLHE40,CARD14,CCND1,CDKN1A,Clec2d (includes others),IL6R,JUN,LIMA1,NFIL3,PDK4,SDC4,SMAD7,VDR | NA |
| eflornithine | NA | chemical drug | NA | 1.68e+00 | 0.0e+00 | ATF4,CDKN1A,ITGAL,LGALS3,SERPINE1,SLC3A2,TGM2 | 434 (23) |
| MMP1 | NA | peptidase | NA | 1.67e+00 | 0.0e+00 | BCL2,CDKN1A,FGFR2,JUN,KDR,MYC,NFKBIA,SERPINE1 | 303 (19) |
| IPMK | 9.00e-02 | kinase | NA | 1.67e+00 | 3.0e-02 | CORO1A,FGL2,JUN,MYC,NT5E,PER1 | NA |
| STIM1 | 1.00e-01 | ion channel | NA | 1.67e+00 | 0.0e+00 | ATF4,BCL2L1,CDKN1A,FOXO1,ITGA11,KDR,KLF4,MYBL1,MYC,TPO | 396 (20) |
| PTPRR | 7.60e-01 | phosphatase | NA | 1.67e+00 | 3.0e-02 | BTG2,CCHCR1,FBXW4,HDAC5,JUN,PACSIN3,PELI3,RALGDS,TELO2 | NA |
| ZC3H12A | 7.00e-02 | enzyme | NA | 1.67e+00 | 0.0e+00 | ADAM19,BCAR3,BCL2,CD244,CD38,CEBPD,CSRP2,CXXC4,GBP4,GBP5,IL1R2,NFKB2,NFKBIZ,PDE7A,PEAK1,PIK3CG,PLEK,PPARG,SEMA4B,SMAD7,TRIB1,ZFP36 | 357 (16) |
| alefacept | NA | biologic drug | NA | 1.66e+00 | 3.0e-02 | CBLB,CD8A,IL2RB,NFKB2,PRF1,PTPN4 | NA |
| FKBP4 | -2.20e-01 | enzyme | NA | 1.66e+00 | 1.0e-02 | PDK4,PPARG,PRDX6,SREBF1 | 147 (7) |
| promegestone | NA | chemical drug | NA | 1.65e+00 | 0.0e+00 | AMOT,BCL2L1,BIRC3,BTG2,CCND1,CDKN1A,FKBP5,GAL,HSD11B2,INHBB,IRS2,MYC,NFKBIA,NR3C2,PDK4,RASD1,SGK1,STAT5A,TIPARP,ZBTB16 | 404 (22) |
| siponimod | NA | chemical drug | NA | 1.63e+00 | 0.0e+00 | BACH2,BCL2,FAM78A,GPR34,HVCN1,KLHL40,MPP7 | NA |
| RPSA | 8.00e-02 | translation regulator | NA | 1.63e+00 | 0.0e+00 | CSF3,GBP4,Ifi47,RELB,TAP1,TRAF1 | 355 (11) |
| ROR1 | 3.50e-01 | kinase | NA | 1.63e+00 | 1.0e-02 | CDKN2C,MDFIC,NDRG1,SERPINE1,SGK1,THBS1 | NA |
| VitaminD3-VDR-RXR | NA | complex | NA | 1.63e+00 | 1.0e-02 | CDKN1A,CXCL10,FOXO1,GADD45A,KLF4,PPARD | NA |
| 5-azacytidine | NA | chemical drug | NA | 1.63e+00 | 0.0e+00 | BCL2L1,CDKN1A,FANCG,FOXO3,GADD45A,HK2,IRS2,ITGAL,KDR,KLF4,KLF6,LOX,MAFF,Mt1,MYC,NDRG1,PLAGL1,PRF1,SLC3A2,SLC7A5,SPHK1,TGM2,THBS1,UPP1,XRCC6 | 367 (22) |
| phenylbutazone | NA | chemical drug | NA | 1.63e+00 | 0.0e+00 | A3GALT2,ADAMTS1,CCND1,Ctla2a,LGALS3,MRC1,RBM3,S100A10,UPP1 | NA |
| CREM | 1.90e-01 | transcription regulator | NA | 1.62e+00 | 0.0e+00 | BCL2,BHLHE40,BTG2,CCND1,CD8A,CSRNP1,ERRFI1,GPR19,IRS2,NFATC1,NFIL3,PER1,SLC16A1,STAR,THBS1,TIPARP | 327 (20) |
| DETA-NONOate | NA | chemical reagent | NA | 1.62e+00 | 0.0e+00 | BCL2L1,BIRC3,CCND1,CDKN1A,MYC,PDE3B,SERPINE1,STAR | 381 (21) |
| EGR1 | 4.50e-01 | transcription regulator | NA | 1.61e+00 | 0.0e+00 | CCL4,CCND1,CDKN1A,FGF2,FTL,GADD45A,HPGD,IL6R,JUN,LEP,MYBL1,MYC,NDRG1,PPARG,SERPINE1,SGK1,SQLE,THBS1 | 414 (18) |
| MET | 6.60e-01 | kinase | NA | 1.61e+00 | 1.0e-02 | BCL2,CCND1,CDKN1A,FGL2,HDC,JUN,KLF4,MERTK,MPP7,MYC,NFKBIZ,PLK2,TSC22D1 | 400 (21) |
| PIM1 | -1.80e-01 | kinase | NA | 1.61e+00 | 1.0e-02 | BCL2,BCL2L1,CD38,CDKN1A,GNL3,MET,MYC | NA |
| cadmium | NA | chemical toxicant | NA | 1.60e+00 | 0.0e+00 | BCL2L1,CCND1,CDKN1A,JUN,LGALS3,LOX,Mt1,MYC,OGG1,SGK1 | 382 (22) |
| 1,25-dihydroxyvitamin D | NA | chemical drug | NA | 1.60e+00 | 0.0e+00 | BNIP3,CCND1,DBT,FGFR4,GLUL,LEP,MYC,SLC7A5,Tlr12,TLR2,VDR | 429 (23) |
| filgrastim | NA | biologic drug | NA | 1.60e+00 | 0.0e+00 | BCL2L1,BIRC3,BTG2,CCL4,CD83,CXCL10,CYSLTR1,DDHD1,FANCA,FGL2,FKBP5,FLT3LG,GADD45A,GATA6,GBP5,GPR34,HPGD,IL1R2,IL2RB,ITGB7,JARID2,JUN,KLF6,LGALS3,LTB4R,MAFF,MAPK6,MBIP,MERTK,MYO10,NOD1,PARP16,PDE4D,RELB,RNF43,S100A10,SAMHD1,SGK1,SLC26A6,SSBP3,TRERF1,TSC22D1,ZNF395 | NA |
| FOXO3 | 7.30e-01 | transcription regulator | NA | 1.60e+00 | 0.0e+00 | ACLY,ACVR1,APEX1,APLN,BNIP3,BTG1,CCND1,CDKN1A,CFLAR,CXCL10,DDIT4,EDNRB,FGFR2,FOXO1,FOXO3,GADD45A,GLUL,GMNN,IMPDH2,IRS1,IRS2,KLF4,LRAT,MET,MRC1,Mt1,MTHFD2,MYC,NAMPT,NDRG1,NFKBIA,NRP1,NRP2,NT5E,OSGIN2,OVOL1,PDE3B,PTPRB,RBM47,SERPINE1,SGK1,SLC7A1,SMAD7,TP53INP1 | 410 (21) |
| ACVR1C | -2.30e-01 | kinase | NA | 1.59e+00 | 0.0e+00 | ADRB3,BCL2L1,CCND1,CDKN1A,KLF4,SERPINE1,SMAD7 | 406 (19) |
| BHLHE40 | -7.90e-01 | transcription regulator | NA | 1.59e+00 | 0.0e+00 | BCL2L1,BTG1,CD38,CSF2RB,CSF3,EGLN3,FGL2,GBP2,HK2,IL1R2,IL2RB,IL6R,IRAK2,LOX,LTB4R,MAFF,MERTK,MET,MITF,MTHFD2,NAMPT,NDRG1,P4HA1,PER1,RGS16,RND3,SAMHD1,SDC4,SLC6A6,SREBF1,TGM2,TIPARP,TYK2,UPP1,ZNFX1 | 392 (17) |
| cisplatin | NA | chemical drug | NA | 1.58e+00 | 0.0e+00 | A3GALT2,ADAMTS1,ALDH1A3,ANK1,ATF4,BCL2,BCL2L1,BIRC3,BTG2,CCND1,CDKN1A,CFLAR,CHEK2,CROCC,Ctla2a,CXCL10,DDIT4,ECE1,FADS3,FLRT3,GADD45A,GRIA2,HAP1,HK2,JUN,KLF12,LGALS3,LRIG1,MBD4,MBNL2,MET,MRC1,Mt1,MYC,MYO1E,NAMPT,NFKBIA,PCDH20,PDE3B,PDE4A,PDK4,PIDD1,PLK2,Pmaip1,PROM1,PTPRO,RBM3,S100A10,SAMHD1,SAT1,SERPINE1,SLC6A6,SLC7A6,TAP1,THBS1,TNK2,TOB1,TP53INP1,TSC22D1,UPP1,VDR,WEE1,XRCC6,ZFP37 | 397 (20) |
| TGFBR1 | 2.90e-01 | kinase | NA | 1.58e+00 | 0.0e+00 | BHLHE40,CCL4,CCND1,CDKN1A,CXCL10,FGF10,HAS2,IL1RN,IL22RA2,KLF4,LIMK1,MST1R,MYC,PDK4,SERPINE1,SMAD7,STAR,ZFP36 | 364 (20) |
| Smad2/3-Smad4 | NA | complex | NA | 1.58e+00 | 1.0e-02 | BCL2,CDKN1A,MYC,SERPINE1,SMAD7 | NA |
| NFE2L2 | 1.00e-01 | transcription regulator | NA | 1.58e+00 | 0.0e+00 | ACE2,ADAMTS1,AGT,APPBP2,ATF4,ATG7,BCL2,BCL2L1,BNIP3,CCL4,CDKN1A,CDKN2C,CXCL10,EPAS1,ETV6,FKBP5,FMO1,FOXO3,FTL,GADD45G,IDH1,IFRD1,IL1R2,IL1RN,IL6R,ITGB7,KCNMB4,KDR,KIFC2,MAFF,MAS1,MITF,MST1R,Mt1,NUCB2,Pmaip1,PPARG,PTPRB,PTPRO,SAT1,SERPINE1,SLC6A9,SLC7A8,SREBF1,TEAD1 | 413 (20) |
| 4-methylnitrosoamino-1-(3-pyridinyl)-1-butanone | NA | chemical toxicant | NA | 1.57e+00 | 0.0e+00 | BCL2,BCL2L1,CDKN1A,IKBKE,IL6R,JUN,LOX,OGG1 | 349 (18) |
| TGFB3 | -1.00e-01 | growth factor | NA | 1.57e+00 | 1.0e-02 | ADAM19,BCL2,BHLHE40,CDKN1A,FGF2,JUN,MYO10,SERPINE1,SKIL,SMAD7,THBS1 | NA |
| KLF10 | 2.30e-01 | transcription regulator | NA | 1.57e+00 | 0.0e+00 | BCL2,CCND1,CDKN1A,PPARG,SERPINE1,SMAD7 | 396 (16) |
| N-nitro-L-arginine methyl ester | NA | chemical drug | NA | 1.56e+00 | 0.0e+00 | AGT,AGTR1,APLN,BCL2,BCL2L1,CD83,NFKBIA,NR3C2,PDK4,PPARD,SERPINE1,SREBF1,TLR2 | 441 (22) |
| tunicamycin | NA | chemical - endogenous non-mammalian | NA | 1.55e+00 | 0.0e+00 | ADCYAP1R1,ATF4,BIRC3,CCND1,CDKN1A,CEBPD,CREB3L2,DDIT4,EDEM1,GADD45A,GPT2,HSD11B1,IFRD1,KLF4,MFSD2A,MTHFR,MYC,NDRG1,NFATC1,NFIL3,NFKBIA,PPARG,PROM1,SEC24D,SLC7A1,SREBF1,STAR,SURF4,TLR2,TPO | 378 (22) |
| caffeic acid phenethyl ester | NA | chemical drug | NA | 1.54e+00 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CD83,CDKN1A,CXCL10,FTL,KLF6,LEP,NFKB2,NFKBIA,RELB,RXRB,TLR2 | 368 (18) |
| TGFB1I1 | 2.30e-01 | transcription regulator | NA | 1.54e+00 | 2.0e-02 | CDKN1A,KLF4,SERPINE1,SMAD7 | NA |
| SHC1 | 0.00e+00 | other | NA | 1.54e+00 | 0.0e+00 | BCL2,BCL2L1,CDKN1A,CXCL10,FGD4,FTL,MAGIX,SDC4,SERPINE1 | 323 (19) |
| fatty acid | NA | chemical - endogenous mammalian | NA | 1.54e+00 | 1.0e-02 | ATG7,BCL2,FFAR4,GPAM,IRS1,LPIN2,NFKBIA,PLIN4,PPARD,PPARG,SERPINE1,SREBF1 | 410 (22) |
| UCP1 | 1.60e-01 | transporter | NA | 1.53e+00 | 0.0e+00 | AMD1,ATF4,ATG7,CXCL10,DBT,GADD45A,GREM2,LEP,MTHFD1L,MTHFD2,MYC,OTUB2,SERPINE1,SLC3A2,SLC6A9,TPPP | 368 (18) |
| medroxyprogesterone acetate | NA | chemical drug | NA | 1.53e+00 | 0.0e+00 | ADAMTS1,BCL2,BCL2L1,BIRC3,BMPR2,BTG2,CCL4,CCND1,CDKN1A,CSF2RB,CSF3R,CXCL10,CXXC4,FAM107A,FGF2,FOXO1,FZD8,GLUL,HSD11B1,IL6R,ITGA1,ITGA11,JUN,LIMK1,MPZL2,MYC,NFKBIA,NOG,P4HA1,PDE3B,PPARG,PRICKLE2,RALGDS,RANBP1,REEP1,SAMHD1,SAT1,SERPINE1,SGK1,SMAD7,STAT5A,SUFU,THBS1,TRAF4,WEE1,WNT5A,ZBTB16 | 471 (20) |
| SORL1 | NA | transporter | NA | 1.53e+00 | 0.0e+00 | ADCYAP1R1,AGT,CMKLR1,EDNRA,EPHA4,FGFR2,FGFR3,GAL,GDF5,ITGA1,ITGA11,LYVE1,MET,NRP2,PGF,PLXND1,SDC4,TGM2,VIP,VIPR2,WNT5A | NA |
| NQO1 | 1.20e-01 | enzyme | NA | 1.53e+00 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,CFLAR,CSF3R,HK2 | 355 (21) |
| epigallocatechin-gallate | NA | chemical drug | NA | 1.52e+00 | 0.0e+00 | BCL2,BCL2L1,CCND1,CDKN1A,CFLAR,CSF3,CXCL10,FADD,FOXO3,GADD45A,GBP4,Ifi47,IRF1,JAK3,JUN,KDR,LEP,MAP3K5,MYC,NFATC1,NFKBIA,RELB,SERPINE1,SLC16A1,TAP1,TFRC,TRAF1 | 323 (14) |
| SOX1 | NA | transcription regulator | NA | 1.51e+00 | 0.0e+00 | ACVR1,BMPER,CITED1,GBP4,IRS1,NRP1,Oasl2,SOX17,TEAD1,TEAD2,WNT5A | NA |
| NOTCH1 | 2.50e-01 | transcription regulator | NA | 1.50e+00 | 0.0e+00 | ADAM19,BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,CEBPD,CFLAR,CSF2RB,EPAS1,EPHA4,FGF2,HK2,IGFBP4,IRF1,LOX,LYVE1,MYC,NFKB2,NRARP,PPARG,RELB,RND3,SERPINE1,WNT5A | 426 (17) |
| dopamine | NA | chemical - endogenous mammalian | NA | 1.50e+00 | 0.0e+00 | APEX1,BCL2,BCL2L1,BTG2,CSRNP1,CXCL10,H3-3A/H3-3B,HRH3,JUN,KLF4,LRTM2,NFATC1,NFKB2,PENK,PER1,PPP2R2A,RASD1,RNLS,SCN1B | 420 (23) |
| HIF1A | 4.00e-02 | transcription regulator | NA | 1.50e+00 | 0.0e+00 | ADAMTS1,AGT,AGTR1,APLN,AXIN2,BACH2,BCL2,BCL2L1,BCL6B,BCS1L,BHLHE40,BNIP3,CCL4,CCND1,CCNT1,CDKN1A,CORO1A,COX5A,CXCL10,DDIT4,ECE1,EDNRA,EDNRB,EGLN3,EPAS1,FHL2,FSCN1,GATA6,HIF3A,HK2,INHBB,IRS2,ITGA1,JUN,KIFC2,LEP,LOX,MAFF,MET,MITF,MST1R,MYC,NDRG1,NEK8,NFKB2,NFKBIA,NFKBIZ,NRARP,NT5E,NUCKS1,P4HA1,PGF,POMK,PPARG,PROM1,RELB,SDC4,SERPINE1,SMAD7,SPHK1,TCF7L2,TFRC,THBS1,TLR2 | 432 (18) |
| bee venom | NA | chemical - endogenous non-mammalian | NA | 1.50e+00 | 0.0e+00 | GADD45A,IFRD1,IRF1,JUN,KLF4,LPIN2,NFIL3,NFKBIA,PTPN11,TRAF1,TSC22D1 | 267 (9) |
| hydrogen peroxide | NA | chemical - endogenous mammalian | NA | 1.49e+00 | 0.0e+00 | AGT,APEX1,ATG7,BANP,BCL2,BCL2L1,BCL9,BIRC3,BTG2,CCL4,CCND1,CDKN1A,CDKN2C,CFLAR,CSF3,CSF3R,DDIT4,EPAS1,FDPS,FGF2,FOXO3,GADD45A,HDC,IRS1,JUN,KDR,KLF4,LTB4R,MITF,MYC,NFIL3,NR3C2,NUCKS1,PGF,Pmaip1,PPARG,PSTPIP2,RAB27A,RCC1,SERPINE1,SGK1,SQLE,STAR,TAP1,TCF3,TFRC,TGM2,TP53INP1,TRAF4,TRPC3,VDR,WNT5A,XRCC6 | 439 (21) |
| N4BP1 | 2.00e-02 | enzyme | NA | 1.49e+00 | 0.0e+00 | CCL4,CSF3,JUN,NFKB2,RELB | 364 (15) |
| NGFR | -3.00e-01 | transmembrane receptor | NA | 1.49e+00 | 1.0e-02 | CCND1,FGFR2,GRIA2,JUN,SERPINE1,SNAP25 | 383 (19) |
| CREB1 | 2.00e-02 | transcription regulator | NA | 1.48e+00 | 0.0e+00 | ADRA1A,BCL2,BCL2L1,BHLHE40,BNIP3,BTG2,CCL4,CCND1,CDKN1A,CEBPD,CGREF1,CSRNP1,CSRP2,ERRFI1,ETV6,FGFR2,FGL2,FOXO3,GADD45A,GADD45G,GAL,GDF11,GPR19,H2-T22,HAS2,HPGD,HSD11B1,IGSF10,IRS2,JUN,KLF4,LEP,MFSD2A,MRC1,MYC,NFIL3,NRP1,NRP2,PCDH20,PDE3B,PENK,PER1,PGM2L1,PITPNB,PLXNA2,PPARG,PTPRR,RASGEF1B,SAT1,SGK1,SLC16A1,SLC19A1,SREBF1,STAR,TCEAL9,TFRC,TIPARP,TPO,UPP1,ZFP36,ZFPM2,Zim1 | 400 (21) |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | NA | chemical toxicant | NA | 1.48e+00 | 0.0e+00 | BACH1,BCL2,EPHX2,FGF2,FKBP5,JUN,Klf16,NRARP,PENK,PYCARD,SGK1,ZBTB16 | 401 (24) |
| MALT1 | 7.00e-02 | peptidase | NA | 1.48e+00 | 1.0e-02 | CD38,CD83,FOXO1,FOXO3,NT5E | NA |
| sodium orthovanadate | NA | chemical reagent | NA | 1.47e+00 | 0.0e+00 | BCL2L1,CCND1,CDKN1A,NFKBIA,SERPINE1,SLC2A5,STAR | 345 (21) |
| gemcitabine | NA | chemical drug | NA | 1.47e+00 | 1.0e-02 | BCL2,BCL2L1,BTG2,CCND1,CDKN1A,DCK,JUN,MYC,NT5E,VMP1 | 425 (23) |
| AMPK | NA | complex | NA | 1.47e+00 | 2.0e-02 | AACS,CDKN1A,CXCL10,CYP2B6,FOXO3,FSCN1,IL1RN,PPARG,SERPINE1,SREBF1,Tsc22d3 | NA |
| IGF1 | -3.00e-02 | growth factor | NA | 1.47e+00 | 0.0e+00 | ATL2,BCL2,BCL2L1,BHLHE40,BIRC3,BTG2,CCL4,CCND1,CDKN1A,CEBPD,CFLAR,CISH,DDIT4,EPAS1,ERRFI1,ETV6,FOXO1,GADD45A,GADD45G,HDC,HSD11B1,HSD11B2,IGFBP4,IRS1,IRS2,JUN,KLF6,LEP,MYC,NFKBIA,NOG,NR3C1,PDLIM2,PENK,PLEK,PLK2,PPARG,SERPINE1,SGK1,SLC12A7,SLC25A25,SQLE,SREBF1,STAR,TAP1,TGM2,THBS1,TTF2,WEE1,ZFP36 | 498 (22) |
| methamphetamine | NA | chemical drug | NA | 1.47e+00 | 0.0e+00 | BCL2,BCL2L1,CXCL11,FOXRED2,GBP2,GRIK3,H3-3A/H3-3B,JUN,KLF12,MAP3K6,MRC1,MTHFR,MYC,RAI1,TPH1,VDR | 394 (24) |
| NRAS | 1.50e-01 | enzyme | NA | 1.46e+00 | 0.0e+00 | BCL2,BCL2L1,CCL4,CCND1,CDKN1A,CX3CL1,CX3CR1,CXXC5,EPAS1,GBP2,HOMER3,IL1RN,Irgm1,KDR,LIMK1,MITF,MYC,PENK,POLD1,TAP1,WEE1 | 344 (16) |
| cyclosporin A | NA | biologic drug | NA | 1.45e+00 | 0.0e+00 | A3GALT2,ADORA1,AGT,AGTR1,BCL2,BCL2L1,BIRC3,CBLB,CCL4,CCND1,CD83,CDKN1A,CFLAR,Ctla2a,CX3CR1,DDIT4,EDNRA,EDNRB,ELL2,FADD,FKBP5,FLT3LG,FOXO1,ITGAL,ITGB7,JUN,KDR,LGALS3,LYVE1,MRC1,MYC,NFATC1,NFKBIA,NR3C1,PDE3B,PRF1,RBM3,S100A10,SERPINE1,SLC12A3,SPHK1,SREBF1,STAT5A,TLE3,UPP1,WNT5A | 413 (16) |
| RB1CC1 | 1.90e-01 | other | NA | 1.45e+00 | 0.0e+00 | ALDH1A3,CCND1,CDKN1A,CXCL10,MYC,SERPINE1,SKIL,SMAD7 | 379 (20) |
| paclitaxel | NA | chemical drug | NA | 1.45e+00 | 0.0e+00 | APLNR,ATF4,BCL2,BCL2L1,BHLHE40,BIRC3,BTG2,CCND1,CDK18,CDKN1A,CFLAR,CRP,CXCL10,FAM53B,FLT3LG,FMO3,FOXO1,FOXO3,JUN,KIFC3,KLF4,LGALS3,MYC,NFATC1,NFKBIA,NT5E,RBM3,SAT1,SCN1B,THBS1,TP53INP1,TRAF1,TSC22D1 | 336 (20) |
| cholecalciferol | NA | chemical - endogenous mammalian | NA | 1.44e+00 | 0.0e+00 | BCL2,BCL2L1,CD38,CD83,CEBPD,CXCL10,HK2,JUN,PDK4,PIP5K1B,PPARG,PTPRB,SERPINE1,VDR | 408 (23) |
| 4-hydroxytamoxifen | NA | chemical drug | NA | 1.44e+00 | 0.0e+00 | BCL2,BCL2L1,BHLHE40,CCND1,CDKN1A,CEBPD,DDIT4,DUSP9,ERRFI1,FADD,FOXO1,JUN,MYC,NFKBIA,PDK4,PTPN11,RASD1,RCC1,RGS16,SGK1,SPHK1,VDR,ZFP36 | 442 (23) |
| NOTCH3 | -2.90e-01 | transcription regulator | NA | 1.44e+00 | 1.0e-02 | BCL2,CDKN1A,CFLAR,EPAS1,ITGA1,ITGA11,KDR,NRARP,PROM1 | 342 (18) |
| CTF1 | -2.20e-01 | cytokine | NA | 1.43e+00 | 0.0e+00 | AGT,CEBPD,CRP,IRF1,IRS1,LEP,PPARG,VIP | 419 (19) |
| AMP | NA | chemical - endogenous mammalian | NA | 1.43e+00 | 0.0e+00 | FOXO1,IRS2,MFSD2A,NT5E,SLC25A25 | 244 (12) |
| mirdametinib | NA | chemical drug | NA | 1.43e+00 | 0.0e+00 | DDIT4,KLF4,MERTK,MRC1,MYC,TBX3,TFRC,TYRO3 | NA |
| okadaic acid | NA | chemical toxicant | NA | 1.42e+00 | 1.0e-02 | BCL2L1,BNIP3,CCND1,CYP2B6,IL1RN,IRS1,JUN,KLF4,MYC,NDRG1 | 405 (23) |
| FOS | 3.20e-01 | transcription regulator | NA | 1.42e+00 | 0.0e+00 | AGT,AGTR1,ALDH1A3,AMIGO1,APLN,BCAR3,BCL9,CCND1,CD244,CDON,CFLAR,CSF3,CXCL10,EPAS1,EPHX2,FGF2,FOXO3,GPSM2,HAS2,HK2,HPGD,HSPB8,IRS2,JUN,KLF6,LGALS3,LOX,MAFK,MAPK6,MET,MPZL2,MYC,NAMPT,NFATC1,NFIL3,NFKB2,NR3C1,NR3C2,PENK,PIK3CB,PIP5K1B,PKN1,PLAGL1,PLK2,Pmaip1,PPP2R2A,PTPRD,PTPRO,RANBP9,RGMA,RIPK4,RPL9,RPS18,S100A10,SEMA6D,SERPINE1,SIRPA,SLC19A1,SMAD7,SMURF1,SPHK1,STAR,TIPARP,WEE1,WNT5A,XYLT1 | 376 (20) |
| NPM1 | 1.90e-01 | transcription regulator | NA | 1.41e+00 | 0.0e+00 | CCL4,COL12A1,COL7A1,CSF3,EGLN3,FZD8,JUN,KLF4,LOX,NR1D1,NUAK1,PGF,SDC4,SEMA6A,SGK1,TRAF6,TRIB1,WNT5A | 191 (8) |
| lomustine | NA | chemical drug | NA | 1.41e+00 | 1.0e-02 | A3GALT2,BIRC3,Ctla2a,LGALS3,MYC,RBM3,S100A10,UPP1 | NA |
| MYO6 | -5.00e-02 | other | NA | 1.41e+00 | 3.0e-02 | BACH2,ERRFI1,GAB2,LBH,NFKBIZ,SDC4,SYNPO2,TNK2 | NA |
| PRKAR1A | 1.10e-01 | kinase | NA | 1.41e+00 | 0.0e+00 | BCL2,CCND1,LEP,PPARG,TEAD1,VDR | 295 (16) |
| Pdgf (complex) | NA | complex | NA | 1.41e+00 | 0.0e+00 | BCL2,CCND1,CDKN1A,ERRFI1,FGF2,FOXO1,FOXO3,IRS2,JUN,MYC,NOG,PPARG,SERPINE1 | 400 (20) |
| PNPT1 | 7.00e-02 | enzyme | NA | 1.41e+00 | 0.0e+00 | BCL2L1,CDKN1A,CXCL10,GBP2,GBP4,Irgm1,MYC,Oasl2 | 346 (14) |
| ERK | NA | group | NA | 1.40e+00 | 0.0e+00 | AGT,BCAR3,BCL2,BCL2L1,BTG2,CCL4,CCND1,CDKN1A,CEBPD,CFLAR,CXCL10,EPAS1,FGF2,FOXO1,FOXO3,HAS3,IRS1,JUN,MAFF,MYC,NDRG1,NFKBIZ,PDK4,PPARD,RAB7B,SERPINE1,TGM2,THBS1,TRPC3,ZFP36 | 371 (21) |
| arsenic | NA | chemical toxicant | NA | 1.39e+00 | 1.0e-02 | BIRC3,EPHX2,FTL,Mt1,TRAF1 | NA |
| apatinib | NA | chemical drug | NA | 1.39e+00 | 2.0e-02 | ATF4,GPT2,SLC3A2,SLC6A9,SLC7A8 | NA |
| OMA1 | -2.50e-01 | peptidase | NA | 1.39e+00 | 3.0e-02 | ATF4,LEP,MTHFD1L,MTHFD2,MYC | NA |
| triamcinolone acetonide | NA | chemical drug | NA | 1.38e+00 | 0.0e+00 | BCL2,BHLHE40,BTG2,CD22,CHL1,EDNRA,ELK3,EPHA4,FGFR2,FKBP5,FOXO3,IGFBP4,JUN,MEGF9,MYC,NFKBIA,NR3C1,PER1,PER3,PLK2,PRF1,RGS16,SEMA6A,SLC16A1,TCF7L2,TRIB1,ZBTB16,ZNF189 | 405 (20) |
| MEF2C | -3.40e-01 | transcription regulator | NA | 1.37e+00 | 0.0e+00 | ACE2,ASPA,BACH2,CCL4,CDKN1A,FGFR3,GJA5,GPR17,HDAC5,HSPB7,JUN,NDUFA5,PLAGL1,PTPRB,STAR,THBS1,ZFP36 | 33 (2) |
| nickel chloride | NA | chemical toxicant | NA | 1.37e+00 | 0.0e+00 | ATF4,BNIP3,DDIT4,EGLN3,EPAS1,HSPB8,JUN,MAFF,NDRG1,P4HA1 | 213 (11) |
| cigarette smoke | NA | chemical toxicant | NA | 1.36e+00 | 0.0e+00 | ATF4,AXIN2,BCL2,BCL2L1,CCND1,CDKN1A,CXCL10,CYP2B6,DDIT4,EPAS1,FOXO3,FTL,GADD45G,HAS3,IRAK2,JUN,KDR,KLF4,LEP,LRAT,MAFF,NFKBIA,OAS2,Oasl2,OGG1,PGF,PTPRB,PYCARD,SERPINE1,SLC6A9,SMAD7,SREBF1,WNT5A | 436 (21) |
| Il3 | NA | cytokine | NA | 1.36e+00 | 0.0e+00 | ADAM19,BCL2,BCL2L1,BHLHE40,CDKN1A,CISH,CSF3,CSF3R,MYC,NFIL3 | 349 (17) |
| SMAD3 | -1.30e-01 | transcription regulator | NA | 1.36e+00 | 0.0e+00 | ACLY,ADAMTS1,ADORA1,ARHGAP27,ATF4,AXIN2,BCL2,CCL4,CCND1,CDKN1A,COL7A1,CRISPLD2,CRP,CXCL10,EN1,FOXO1,FOXO3,FZD8,HAS2,JUN,LOX,MYC,PCSK5,PPARD,SERPINE1,SKIL,SMAD7,SPHK1,STAR,TBX3,THBS1,VIP,ZFP36 | 400 (22) |
| berberine | NA | chemical drug | NA | 1.36e+00 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CCNT1,CDKN1A,CFLAR,CYP2B6,PPARD,PPARG,SAT1,SPHK1,SREBF1 | 343 (24) |
| 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene | NA | chemical toxicant | NA | 1.36e+00 | 2.0e-02 | CCND1,CDKN1A,CYP2B6,ENKD1,MAFF,Mt1,PDE3B,PTPN11,SAT1,SREBF1,TMPRSS2 | NA |
| SOCS1 | -2.60e-01 | other | NA | 1.36e+00 | 0.0e+00 | BCL2,BCL2L1,CCND1,CDKN1A,CFLAR,CISH,CSF3,CXCL10,FKBP5,GBP5,Ifi47,IL2RB,IRF1,IRS1,IRS2,JUN,MAP3K5,OAS2,Oasl2,RALGDS,STAT5A,TGM2 | 356 (18) |
| JQ1 | NA | chemical reagent | NA | 1.36e+00 | 1.0e-02 | BCL2,BCL2L1,BIRC3,CCND1,CFLAR,CISH,FOXO3,GADD45G,MYC,NFKB2,NFKBIA,NRP1,Oasl2,TLR2,TRAF1 | 416 (19) |
| CCND1 | -8.20e-01 | transcription regulator | NA | 1.34e+00 | 1.0e-02 | AFAP1,ALDH1A3,BCL2,BCLAF1,CCND1,CDKN1A,CDKN2C,CLSPN,DTL,ERRFI1,HSPB8,MAFF,MAP3K5,MARK1,MEIS2,MYBL1,MYC,NT5E,PCYT1A,PPARG,THNSL1,TMPRSS2,TP53INP1,ZFP28,ZNF423 | 421 (24) |
| RNF138 | 1.90e-01 | enzyme | NA | 1.34e+00 | 0.0e+00 | BCL2L1,BIRC3,NAMPT,NFKB2,RGS16 | 150 (8) |
| nickel | NA | chemical toxicant | NA | 1.34e+00 | 0.0e+00 | FGF2,IL1RN,JUN,Mt1,SERPINE1 | 410 (22) |
| ASXL2 | 2.70e-01 | other | NA | 1.34e+00 | 1.0e-02 | GPCPD1,HK2,HSD11B1,PPARG,SERPINE1 | 158 (7) |
| LLGL2 | -7.10e-01 | other | NA | 1.34e+00 | 1.0e-02 | CDKN2C,FSCN1,NDRG1,SERPINE1,SGK1 | NA |
| AGTR1 | 6.70e-01 | G-protein coupled receptor | NA | 1.34e+00 | 2.0e-02 | ACE2,AGT,CCND1,JUN,SERPINE1,SGK1 | NA |
| CHRNA7 | 1.00e-02 | transmembrane receptor | NA | 1.34e+00 | 2.0e-02 | CDKN1A,CXCL10,FGF10,IL1RN,PPARD | NA |
| ATP7B | 7.70e-01 | transporter | NA | 1.34e+00 | 3.0e-02 | AACS,ACLY,FDPS,Mt1,SQLE | NA |
| dihydrotestosterone | NA | chemical - endogenous mammalian | NA | 1.34e+00 | 0.0e+00 | ACLY,ADAMTS1,ADH1C,ADRB3,AGT,AGTR1,ALDH1A3,AMD1,ATP13A2,AXIN2,BCL2,BCL2L1,BMPR2,BTG2,CCND1,CDKN1A,CMKLR1,CREB3L2,CX3CL1,DTL,FGF2,FKBP5,FOXO1,FOXP2,FTL,GLUL,HK2,HOXC6,HPGD,HSD11B2,IGFBP4,IL6R,INHBB,IRS1,IRS2,JUN,LEP,LOX,MAFF,MARK1,Mt1,MYC,NDRG1,NFKBIA,NR3C1,PER1,PLAGL1,POLR2D,PPARG,RAB27A,RPL9,SGK1,SLC2A5,SLC3A2,SLC7A6,SLC7A8,SQLE,SREBF1,STAR,STAT5A,TGM2,THBS1,TMPRSS2,WEE1,WNT5A,ZBTB16 | 500 (18) |
| FOXA1 | -1.00e-02 | transcription regulator | NA | 1.34e+00 | 0.0e+00 | ADH1C,Akr1c14,CDKN1A,CXCL10,DDIT4,ELK3,EN1,GBP2,MYC,PISD,RORA,SLC10A6,SPSB1,STAT5A,TMPRSS2,TRIM2,UST | 384 (18) |
| BMP6 | 2.90e-01 | growth factor | NA | 1.34e+00 | 1.0e-02 | ADAMTS1,CDKN1A,CDKN2C,ERRFI1,INHBB,KLF4,NOG,SERPINE1,SMAD7,STAR | NA |
| pirinixic acid | NA | chemical toxicant | NA | 1.34e+00 | 0.0e+00 | ACACB,ADH1C,ALDH9A1,BNIP3,CCND1,CCNT1,CDKN1A,CIDEC,CRP,CYP2B6,GADD45A,GLUL,GPAM,HOXC6,IL1RN,KDR,LEP,LGALS3,LPIN2,MET,MGST2,MYC,NFKBIA,NR1D1,PCSK5,PDK4,PLIN4,PPARG,RORA,RXRB,SERPINE1,SLC16A13,SLC25A32,SREBF1,STK36,WEE1 | 401 (23) |
| HSF1 | -2.00e-02 | transcription regulator | NA | 1.34e+00 | 0.0e+00 | ACLY,ATG7,BCL2,BCL2L1,C1orf226,CFLAR,CSF3,CSRP2,HDAC5,HSPB8,IGFBP4,INHBB,IRS1,JARID2,JUN,LRIG1,Madcam1,MITF,PLIN4,PPARG,RAD51D,RANBP1,SREBF1,STAR,SYCE1,ZFAND2A | 417 (21) |
| EDN1 | -3.00e-02 | cytokine | NA | 1.33e+00 | 0.0e+00 | ADAM19,APLN,BCL2,CCND1,COL7A1,EDNRA,EDNRB,ERRFI1,FGF2,JUN,LEP,MAS1,MITF,MYC,RAB3A,SERPINE1,TGM2,THBS1 | 404 (23) |
| GCG | NA | other | NA | 1.31e+00 | 1.0e-02 | ADRB3,BCL2,BCL2L1,BTG2,CARD14,CBS/LOC102724560,FDPS,GREM2,IGFBP4,LIMA1,NR3C1,SLC25A25,SREBF1 | 529 (23) |
| CNR1 | -3.80e-01 | G-protein coupled receptor | NA | 1.31e+00 | 0.0e+00 | ADORA1,ADRB3,CXCL10,ERRFI1,FGF10,FGF2,LEP,NOG,NR3C1,PENK,PIK3C2A,RGMA,SMURF1,SREBF1,SUFU | 404 (20) |
| IGFBP3 | 4.10e-01 | other | NA | 1.31e+00 | 0.0e+00 | BCL2,BCL2L1,CCL4,CD38,CDKN1A,LYVE1,SERPINE1 | 382 (22) |
| Usp17la (includes others) | NA | peptidase | NA | 1.30e+00 | 1.0e-02 | CISH,KLF4,MYC,PROM1 | NA |
| Hif1 | NA | complex | NA | 1.29e+00 | 0.0e+00 | APLN,BCL2,BNIP3,CD83,CDKN1A,DDIT4,HIF3A,MET,SERPINE1,SLC16A1,TFRC | 374 (18) |
| NLRP3 | -4.90e-01 | other | NA | 1.29e+00 | 1.0e-02 | BCL2,CCL24,CCL4,CSF3,CXCL10,IL22RA2,IRF1,MAP3K4,MRC1,NFKB2,OGG1,RELB,SMAD7,TAP1 | 349 (14) |
| 5-N-ethylcarboxamido adenosine | NA | chemical reagent | NA | 1.29e+00 | 0.0e+00 | BHLHE40,BTG2,CEBPD,CSF2RB,FGF2,GADD45A,HK2,KLF6,NFIL3,NRP1,NT5E,PLK2,PROM1,SERPINE1,SOX17,THBS1,VDR | 440 (21) |
| indole-3-carbinol | NA | chemical drug | NA | 1.29e+00 | 2.0e-02 | BCL2,CCND1,CDKN1A,FMO1,TRAF1 | NA |
| arachidonic acid | NA | chemical - endogenous mammalian | NA | 1.28e+00 | 1.0e-02 | BCL2,CD83,JUN,KDR,KLF6,MRC1,NFKBIA,PENK,PPARG,SREBF1,STAR | 355 (21) |
| (+)-MK-801 | NA | chemical drug | NA | 1.28e+00 | 2.0e-02 | CCND1,CDKN1A,FGF2,GJA5,IL6R,INPP4B,JUN,NFKBIA | NA |
| dinoprost | NA | chemical - endogenous mammalian | NA | 1.28e+00 | 0.0e+00 | CCND1,FGF2,HSD11B2,JUN,MAPK6,MYC,NFIL3,SCN1B,STAR,THBS1 | 412 (20) |
| Map3k7 | NA | kinase | NA | 1.28e+00 | 0.0e+00 | BCL2L1,BHLHE40,CCL4,CXCL10,FGF10,FGL2,HAS2,JUN,NFKBIA,NFKBIZ,PROM1,SPHK1,TSC22D1 | 364 (15) |
| Lh | NA | complex | NA | 1.27e+00 | 0.0e+00 | ADAMTS1,CFLAR,DUSP9,FGFR2,FGFR4,FKBP5,GADD45G,HAS2,HK2,HSD11B1,INHBB,JUN,MAP3K5,MAPK6,MYC,PDE4D,PER1,PHKA2,PI4K2A,RAB27A,RGS16,RPL9,RPS18,SGK1,SLC7A1,SNAP25,STAR,TBX3,THBS1,TP53I11,TRIB1,TYRO3,UPP1,ZBTB16 | 379 (23) |
| EIF4E | 2.20e-01 | translation regulator | NA | 1.27e+00 | 0.0e+00 | ADAMTS15,BCL2,BCL2L1,BCLAF1,BNIP3,CCND1,CDKN1A,CX3CR1,FGF2,IGFBP4,LSM10,MYC,NFKBIA,NRP1,PGF,SLC2A5,SPHK1,UBA7,UPP1,VIP | 386 (26) |
| TSC22D3 | NA | transcription regulator | NA | 1.27e+00 | 0.0e+00 | BCL2,CCND1,CD83,CDKN1A,LEP,PPARG,SGK1,SMURF1,TLR2 | 385 (21) |
| ANXA2 | 2.20e-01 | other | NA | 1.27e+00 | 1.0e-02 | CDKN1A,GADD45A,JUN,MYC,S100A10 | NA |
| kainic acid | NA | chemical toxicant | NA | 1.26e+00 | 0.0e+00 | ATF4,BCL2,BCL2L1,BTG2,CCND1,CSRNP1,ERRFI1,FGF10,FGF2,FGFR2,FGFR3,GDF5,GPR19,GRIA2,HDC,JUN,KDR,NFIL3,NR3C1,NR3C2,PENK,PER1,SLC16A1,TCF7L2,TIPARP | 423 (23) |
| PAF1 | 2.60e-01 | other | NA | 1.26e+00 | 0.0e+00 | ARL4A,BIRC3,IFI44L,KLF4,NFKBIZ,OAS2,SDC4,SERPINE1,ZFP36,ZNFX1 | NA |
| trovafloxacin | NA | chemical drug | NA | 1.26e+00 | 0.0e+00 | BHLHE40,BIRC3,CDKN1A,ERRFI1,Igtp,IRF1,NFKBIA,SERPINE1,TGM2,THBS1 | 376 (12) |
| DNMT1 | -2.00e-01 | enzyme | NA | 1.26e+00 | 1.0e-02 | CDKN1A,Mt1,MYC,NDRG1,PPARG,PRF1,PYCARD,RGMA,SOX17,WNT5A | NA |
| laduviglusib | NA | chemical drug | NA | 1.26e+00 | 0.0e+00 | AXIN2,KLF4,MYC,NFKB2,PPARG,SOX17,SREBF1,TBX3 | 398 (24) |
| vatalanib | NA | chemical drug | NA | 1.25e+00 | 0.0e+00 | BCL2,BCL2L1,CCND1,CDKN1A,KDR | 375 (22) |
| MAP3K1 | NA | kinase | NA | 1.25e+00 | 1.0e-02 | BIRC3,CCND1,JUN,PPARD,SERPINE1,THBS1,TPH1 | 373 (21) |
| FGF1 | -1.40e-01 | growth factor | NA | 1.25e+00 | 0.0e+00 | AXIN2,CCND1,CDKN1A,COX5A,EN1,FZD8,GADD45G,HAS2,Irgm1,IRS1,JUN,MYC,SGMS1,TCF3,TCF7L2,TGM2,THBS1 | 420 (23) |
| MTOR | -9.00e-02 | kinase | NA | 1.25e+00 | 0.0e+00 | ACACB,ACLY,ALDH1A3,ATG7,BCL2,BCL2L1,BNIP3,CCND1,CDKN1A,CEBPD,CFLAR,DDIT4,EIF3A,EPAS1,FADD,FDPS,FGFR3,HK2,HSD11B1,IL2RB,IRF1,IRS1,IRS2,LEP,MYC,PDE4A,PDK4,PLD2,PPARD,PPARG,PRF1,RPS18,RXRB,SREBF1,TCF7L2,TMPRSS2,TPPP | 424 (21) |
| ERN1 | 6.00e-02 | kinase | NA | 1.25e+00 | 1.0e-02 | ATF4,CEBPD,CREB3L2,EDEM1,JUN,MPZL2,OAS2,PPARG,SEC24D,SELENOS,SLC7A1,SURF4,TINAGL1,TMPRSS2 | 205 (7) |
| IL3 | NA | cytokine | NA | 1.24e+00 | 0.0e+00 | BCL2,BCL2L1,BIRC3,BTG2,CCND1,CD83,CDKN1A,CIAPIN1,CISH,CSF3,FGFR4,GADD45A,GADD45G,HK2,HUS1,IMPDH2,ITGB7,JUN,Mt1,MYC,NFATC1,NRP1,PTPN11,RANBP1,RBM3,SLC3A2,SLC7A5,TAX1BP1,TLR2,TYK2 | 385 (23) |
| TREM1 | 3.20e-01 | transmembrane receptor | NA | 1.24e+00 | 0.0e+00 | ABL2,BCL2,CD83,CXCL10,DTL,HECW2,HS3ST3B1,IL6R,IRF1,MAFF,NFKB2,NFKBIA,NRIP3,NT5E,PPARG,RGS16,TCEAL9,THBS1,TLR2,WNT5A | 422 (18) |
| CRNDE | NA | other | NA | 1.24e+00 | 0.0e+00 | ABL2,BCL2L1,CDKN1A,FGFR3,PGF,RASA3 | 168 (7) |
| epinephrine | NA | chemical - endogenous mammalian | NA | 1.23e+00 | 3.0e-02 | CCND1,CDKN1A,CYP2B6,HK2,LEP,PENK,PER1,TFRC | NA |
| Smad | NA | complex | NA | 1.23e+00 | 0.0e+00 | CDKN1A,MYC,SERPINE1,SMAD7,VIP,WNT5A | 258 (7) |
| crocidolite asbestos | NA | chemical toxicant | NA | 1.23e+00 | 1.0e-02 | CCND1,GADD45A,JUN,MET,MYC | NA |
| MYC | 7.80e-01 | transcription regulator | NA | 1.22e+00 | 0.0e+00 | ACLY,ACVR1,ADAMTS1,ADARB1,AMD1,APEX1,ATF4,ATP13A2,BCL2,BCL2L1,BMPER,CCND1,CDKN1A,CEBPD,CFLAR,CIDEC,CITED1,Clec2d (includes others),COX5A,CSRP2,CXCL10,CXCL11,DDIT4,EIF2S2,EIF4A1,FGF10,FKBP5,GADD45A,GADD45G,GATA6,GBP2,GBP4,GLUL,GPT2,H3-3A/H3-3B,H6PD,HAS2,HK2,HSD11B2,IDH1,IFI44L,IMPA2,IRF6,IRS1,ITGA1,ITGAL,JARID2,JUN,KDR,KLF4,KLF6,LEP,LIMA1,LOX,MITF,MRC1,Mt1,MTBP,MTHFR,MYC,NDRG1,NFKBIA,NRP1,Oasl2,OVOL1,PML,POLD1,POLR2D,PPARD,PPARG,Ppp1r15a,PROM1,RANBP1,RCC1,ROCK2,RPL9,RPS18,S100A10,SAT1,Serbp1,SERPINE1,SGK1,SLC16A1,SLC3A2,SLC7A5,SOX17,SREBF1,TAF1D,TCF3,TEAD1,TEAD2,TFRC,THBS1,TOB1,VMP1,WEE1,WNT5A,ZFP36,ZFP37 | 408 (21) |
| vitamin D | NA | chemical drug | NA | 1.22e+00 | 3.0e-02 | ADAMTS1,BCL2,CDKN1A,NFKBIA,PPARG,SGK1,VDR | NA |
| NFKBIB | 5.60e-01 | transcription regulator | NA | 1.21e+00 | 1.0e-02 | BCL2L1,CFLAR,FGF10,NFKBIA,SMAD7,TP53INP1,TRAF6 | 365 (14) |
| S-nitroso-N-acetyl-DL-penicillamine | NA | chemical reagent | NA | 1.21e+00 | 0.0e+00 | BCL2,BNIP3,CDKN1A,GRIA2,MST1R,MYC,PPARD,S100A10 | 404 (25) |
| ERBB3 | -3.50e-01 | kinase | NA | 1.21e+00 | 1.0e-02 | ADAM19,CCND1,CDKN1A,CDKN2C,FGF2,HAS2,NDRG1,SERPINE1,SGK1,TGM2,THBS1 | NA |
| nitrofurantoin | NA | chemical drug | NA | 1.20e+00 | 0.0e+00 | ADAMTS1,AMD1,APEX1,BCL2L1,BTG2,CCND1,CRP,CXCL10,GADD45A,Gulo,IFRD1,LGALS3,LOX,MET,Mt1,MYC,NFKBIA,PCYT1A,S100A10 | NA |
| progestin | NA | chemical drug | NA | 1.20e+00 | 0.0e+00 | BCL2,CCND1,FOXO1,NFKBIA,PDK4,STAT5A,TBC1D14 | 254 (12) |
| hexachlorobenzene | NA | chemical toxicant | NA | 1.20e+00 | 1.0e-02 | A3GALT2,Ctla2a,LGALS3,MRC1,MYC,S100A10,UPP1 | NA |
| amitriptyline | NA | chemical drug | NA | 1.20e+00 | 2.0e-02 | CDKN1A,CYP2B6,FGF2,NR3C1 | NA |
| HEIH | NA | other | NA | 1.20e+00 | 4.0e-02 | BCL2L1,FGF10,FGF2,JUN | NA |
| SMAD2 | -4.10e-01 | transcription regulator | NA | 1.20e+00 | 4.0e-02 | CDKN1A,CRISPLD2,HAS2,IL6R,MET,SERPINE1,SKIL,SMAD7,SPHK1,THBS1 | NA |
| EPO | NA | cytokine | NA | 1.19e+00 | 2.0e-02 | ANK1,BCL2,BCL2L1,BLM,BTG1,CDKN1A,CISH,FGF2,GLUL,JUN,MRC1,MYC,NFATC1,NFKBIA,NR3C1,PDLIM2,PTPRB,ROCK2,SMAD7,TFRC,TPH1,ZFHX2 | NA |
| mir-142 | NA | microRNA | NA | 1.19e+00 | 0.0e+00 | AFAP1,GBP2,GBP4,GBP5,IL2RB,INPP4B,IRF1,ITGA1,NFKB2,NRP1,PIP5K1B,PROM1,TSC22D1 | 254 (7) |
| nitric oxide | NA | chemical - endogenous mammalian | NA | 1.19e+00 | 0.0e+00 | AGTR1,BCL2,BCL2L1,BNIP3,CCND1,CDKN1A,CXCL10,ECE1,GADD45A,JUN,Mt1,MYC,NDRG1,NR3C1,PGF,SGK1,TFRC,THBS1 | 400 (20) |
| oblimersen | NA | biologic drug | NA | 1.19e+00 | 0.0e+00 | BCL2,BCL2L1,CDKN1A,CEBPD,GADD45A,IFRD1,MAFF,OAS2,TRIM14 | NA |
| CD40 | 1.50e-01 | transmembrane receptor | NA | 1.18e+00 | 0.0e+00 | AGTR1,ATF4,BCL2,BCL2L1,BIRC3,CCL4,CCND1,CD22,CD38,CD83,CD8A,CDKN1A,CFLAR,COX5A,CSF3,CX3CL1,CXCL10,CYSLTR1,EDEM1,FLT3LG,GNL3,HK2,IL1RN,IL2RB,IL6R,IRF1,ITGAL,JUN,KLF4,LGALS3,MAP3K6,MET,MYC,NDUFA5,NFATC1,NFKB2,NFKBIA,NIP7,PRF1,RCL1,RRP12,SERPINE1,SLC19A1,SMAD7,TAP1,TCF3,TLR2,TRAF1,TRAF4,TRAF5,WDR43,ZBTB16 | 359 (15) |
| simvastatin | NA | chemical drug | NA | 1.18e+00 | 0.0e+00 | ACVR1,ADAMTS1,ADCYAP1R1,BCL2,BCL2L1,CCND1,CDKN1A,CFLAR,CRP,CYP2B6,IRF1,ITGAL,KLF4,MYC,NFATC1,NFKBIA,SDC4,SERPINE1,TLR2 | 260 (12) |
| pimozide | NA | chemical drug | NA | 1.17e+00 | 0.0e+00 | BCL2,BCL2L1,CCND1,CISH,PRF1 | 234 (12) |
| resveratrol | NA | chemical drug | NA | 1.17e+00 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,CFLAR,CX3CL1,CX3CR1,CXCL10,ECE1,FOXO1,FOXO3,HAS2,ITGA1,ITGAL,JUN,KDR,LEP,MITF,MRC1,MYC,NFATC1,NFKBIA,PDK4,PPARG,PPP1R13B,PTPN11,SERPINE1,SPHK1,STAR,TFRC,VDR | 424 (21) |
| METTL3 | -3.30e-01 | enzyme | NA | 1.17e+00 | 0.0e+00 | ASAP3,BTG2,CDKN1A,CGREF1,CISH,CX3CR1,CXCL10,JPH2,JUN,KLF4,KLHL26,MYBL1,PTPN11,ZNF423 | 226 (14) |
| spermine | NA | chemical - endogenous mammalian | NA | 1.17e+00 | 0.0e+00 | CCL4,ITGAL,SAT1,TLR2 | 160 (7) |
| GC-GCR dimer | NA | complex | NA | 1.17e+00 | 1.0e-02 | AGT,IL1R2,IL1RN,NFKBIA,PDK4 | NA |
| ERK1/2 | NA | group | NA | 1.16e+00 | 0.0e+00 | APLN,BCL2,BCL2L1,BIRC3,CCL4,CCND1,CDKN1A,CFLAR,CXCL10,ECE1,FGF2,FGFR2,FKBP5,FOXO1,HAS2,HK2,HPGD,IRS2,JUN,MKNK1,MYC,NAMPT,PTPN11,SERPINE1,SGK1,SKIL,SLC12A7,STAR,TAP1 | 482 (22) |
| 8-bromo-cAMP | NA | chemical reagent | NA | 1.16e+00 | 0.0e+00 | ADRB3,BCL2L1,BIRC3,BMPR2,CCND1,CDKN1A,CSF2RB,CSF3R,CXXC4,CYP2B6,FGF2,FOXO1,FZD8,GATA6,GLUL,HPGD,INHBB,ITGA1,ITGA11,JUN,KDR,LIMK1,LOX,MYC,NFIL3,NFKBIA,NOG,NRP1,P4HA1,PDE3B,PDE4A,PDE4D,PPARD,PPARG,PRICKLE2,RALGDS,SAT1,SERPINE1,SGK1,SMAD7,STAR,STAT5A,SUFU,THBS1,TPO,TRAF4,WEE1,WNT5A,ZBTB16 | 475 (21) |
| GMNN | 7.20e-01 | transcription regulator | NA | 1.16e+00 | 0.0e+00 | ACVR1,BMPER,CDKN1A,CITED1,FGF2,GBP4,IRS1,NRP1,Oasl2,SOX17,TEAD1,TEAD2,WNT5A | NA |
| SOX3 | NA | transcription regulator | NA | 1.16e+00 | 0.0e+00 | ACVR1,BMPER,CITED1,GBP4,IRS1,NRP1,Oasl2,SOX17,TEAD1,TEAD2,WNT5A,ZBTB16 | NA |
| IRF2 | -9.00e-02 | transcription regulator | NA | 1.16e+00 | 0.0e+00 | BCL2,C1QTNF1,CA12,CCND1,CDKN1A,CIDEC,CXCL10,HK2,IDH1,Ifi47,IRF1,KLF4,MAPK6,NAMPT,SLC7A1,TAP1 | 365 (21) |
| cocaine | NA | chemical drug | NA | 1.15e+00 | 0.0e+00 | BCL2,BHLHE40,FGF2,FHL2,FOXO1,FOXO3,GADD45A,GPR19,GRIA2,IRS2,JUN,Klf16,NFKB2,PER1,SLC16A10,THBS1,TIPARP | 425 (22) |
| staurosporine | NA | chemical drug | NA | 1.15e+00 | 0.0e+00 | BCL2,BCL2L1,BTG2,CCL4,CCND1,CDKN1A,CSF3R,HDC,INHBB,MYC,NR3C2,SERPINE1,STAR,VDR | 356 (19) |
| Z-LLL-CHO | NA | chemical - protease inhibitor | NA | 1.14e+00 | 0.0e+00 | ATF4,BCL2,BCL2L1,BIRC3,CBS/LOC102724560,CCND1,CDKN1A,CFLAR,CHD1,CISH,CRP,CXCL10,EPAS1,FADD,FGF2,FOXO1,HAS2,IRS1,IRS2,JUN,MAPK6,MET,MITF,MST1R,MYC,NFKB2,NFKBIA,NR3C1,OGG1,PPARG,RANBP1,SLC12A3,THBS1,TNK2,VDR,ZNF395 | 404 (19) |
| GNAS | 4.00e-02 | enzyme | NA | 1.14e+00 | 0.0e+00 | ADAMTS1,BACH2,BCL2L1,CD22,DTX4,GADD45G,KLF4,LEP,MAFF,MYC,NRP1,PDE3B,PDE4A,PENK,PLK2,PPARG,PRDX6,RAPGEF4,RASD1,STAR,THBS1,TRIB1,TSC22D1 | 417 (23) |
| BCR-ABL1 | NA | fusion gene/product | NA | 1.14e+00 | 0.0e+00 | BCL2,BCL2L1,BLM,CCND1,CDKN2C,CSF2RB,CSF3R,EPAS1,HK2,MYC,PIK3CG,SGMS1 | 367 (21) |
| EPAS1 | 5.90e-01 | transcription regulator | NA | 1.14e+00 | 0.0e+00 | ACLY,APLN,BCL2,BHLHE40,BIRC3,BNIP3,CA12,CCND1,CDKN1A,CORO1A,EGLN3,FGF2,FMO5,GPT2,IL2RB,INHBB,IRS2,Irs3,KDR,LEP,LOX,MAFF,NAMPT,NDRG1,NEK8,NFIL3,NRARP,NT5E,PGF,PPARG,PRF1,SERPINE1,SLC7A5,SPHK1,SREBF1,ZNF423 | 414 (23) |
| TNFSF11 | NA | cytokine | NA | 1.13e+00 | 0.0e+00 | ADRA1A,BCL2,BCL2L1,CCL4,CCND1,CD300LF,CD83,CDKN1A,CSF3,FGR,FHL2,FOXO1,IFRD1,IKBKE,IL1RN,ITGAL,JUN,LDB2,LIMK1,MYC,NFATC1,NFIL3,NFKB2,NFKBIA,NFKBIZ,PAG1,RALGDS,RCL1,RELB,RGS16,SDC4,SERPINE1,TLR2,TRAF1,TRAF6 | 334 (12) |
| phenacetin | NA | chemical drug | NA | 1.13e+00 | 0.0e+00 | A3GALT2,BIRC3,LGALS3,MRC1,MYC,S100A10,UPP1 | 249 (7) |
| ARID2 | -9.00e-02 | transcription regulator | NA | 1.13e+00 | 1.0e-02 | ACVR1,ADAM19,FGFR2,HTR7,NR3C1,THBS1,WNT5A | NA |
| AIP | 2.40e-01 | transcription regulator | NA | 1.13e+00 | 1.0e-02 | ADGRV1,ADRA1D,CMKLR1,CX3CR1,CYSLTR1,PLAGL1,RGS16 | NA |
| NFKB2 | -7.60e-01 | transcription regulator | NA | 1.12e+00 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CD83,CDKN1A,CFLAR,CX3CL1,GBP5,IGFBP4,KCNMB4,Madcam1,MYC,NFKB2,TRAF1 | 198 (11) |
| TCR | NA | complex | NA | 1.12e+00 | 0.0e+00 | ALOX12,BACH2,BCL2,BCL2L1,BIRC3,CBLB,CCL4,CCND1,CD38,CFLAR,CISH,CXCL10,CXCL11,DHX58,ELL2,GADD45G,GBP4,IFI44L,IRF1,ITGB7,JUN,LPIN2,MYC,NFATC1,NFKB2,NFKBIA,NIP7,NR3C1,NRP1,PDE3B,PRDX6,PRF1,RELB,RPL9,SKIL,SMAD7,SPHK1,STAT5A,TCF3,TLE3,TOB1,TRAF5,TSC22D1,USP21,VDR,ZNFX1 | 373 (19) |
| puromycin aminonucleoside | NA | chemical reagent | NA | 1.12e+00 | 2.0e-02 | A3GALT2,ADAMTS1,Ctla2a,CYP2B6,LGALS3,MRC1,MYC,RBM3,S100A10,UPP1 | NA |
| CBX5 | -6.00e-02 | transcription regulator | NA | 1.12e+00 | 2.0e-02 | AXIN2,CDKN1A,CYP2B6,GCNT3,NNT,PPARG,QPRT,RORA,SLC2A10,SLC7A8,STAT5A | NA |
| CAV1 | 2.50e-01 | transmembrane receptor | NA | 1.11e+00 | 0.0e+00 | ADGRG2,CCND1,CDKN1A,CXCL10,FGF2,HK2,INHBB,KDR,LEP,NFATC1,NR3C2,PROM1,SERPINE1,SKIL,THBS1 | 423 (22) |
| PIK3CA | 0.00e+00 | kinase | NA | 1.11e+00 | 0.0e+00 | ADAMTS1,ANK1,BIRC3,CCND1,CEBPD,CSF3,IRS1,IRS2,JUN,KDR,LLGL2,LOX,MYC,NFKBIA,PIK3CB,PIK3CG,SERPINE1,SREBF1 | 411 (20) |
| KAT2A | -5.40e-01 | enzyme | NA | 1.11e+00 | 0.0e+00 | ADAMTS1,BCL2L1,BNIP3,CCND1,CSRP2,EDEM1,IMPA2,JUN,MITF,PROM1,PTPRO,RANBP1,SLC16A1,TAF1D | 402 (17) |
| INSIG1 | 5.20e-01 | other | NA | 1.10e+00 | 0.0e+00 | AACS,ACACB,ACLY,ATF4,CXCL10,FDPS,GPAM,IRS2,JUN,MRC1,NFKBIZ,PPARG,PRF1,RAB27A,SQLE,SREBF1,STAT5A | 281 (9) |
| DLX2 | 6.00e-02 | transcription regulator | NA | 1.10e+00 | 1.0e-02 | BMPER,CDKN1A,MYC,TELO2 | NA |
| AXIN1 | NA | other | NA | 1.10e+00 | 1.0e-02 | CCND1,CSRNP1,PPARG,TCF7L2 | NA |
| HOXA5 | -2.70e-01 | transcription regulator | NA | 1.10e+00 | 4.0e-02 | BIRC3,CDKN1A,FGF10,NFKBIA,SAT1 | NA |
| TWIST1 | -3.20e-01 | transcription regulator | NA | 1.10e+00 | 0.0e+00 | ADAMTS1,BCL2,C1QTNF1,CBX2,CDKN1A,FGF10,FGFR2,FGFR3,FOXO1,IGFBP4,LGALS3,MET,MRC1,NT5E,PROM1,RELB,SPHK1,TCF3 | 360 (18) |
| MYOD1 | 1.20e-01 | transcription regulator | NA | 1.10e+00 | 1.0e-02 | ACACB,ADORA1,AGT,BCL2,BCL2L1,CDKN1A,DYSF,GADD45A,GADD45G,GREM2,HAS2,HSPB8,KIFC3,KLF6,PRIMA1,SBK1,SMAD7,STAM,TEAD2,UBA7 | 406 (21) |
| KLF6 | 5.90e-01 | transcription regulator | NA | 1.09e+00 | 0.0e+00 | AGT,BCL2L1,BIRC3,CCL24,CD38,CD83,CDKN1A,CFLAR,CMKLR1,CSF2RB,HK2,IRAK2,IRF1,LGALS3,MRC1,MYC,NAMPT,NFKB2,NFKBIA,NR1D1,PPARG,RELB,SGK1,SPSB1,STAT5A,TRAF1,UPP1,ZNFX1 | 389 (22) |
| CARM1 | -7.00e-02 | transcription regulator | NA | 1.08e+00 | 0.0e+00 | CDKN1A,CSF3,CXCL10,DDIT4,EPHX2,FTL,GADD45A,IGFBP4,MYC | 430 (26) |
| KRAS | 2.00e-01 | enzyme | NA | 1.08e+00 | 0.0e+00 | ACLY,ACVR1,ADAMTS1,AGT,Akr1c14,ANK1,ATG7,AXIN2,BCL2,BCL2L1,BIRC3,BMPR2,BNIP3,CCND1,CDKN1A,CDKN2C,CSF2RB,CSF3,CSF3R,CX3CL1,CXCL10,EDEM1,FGF10,FLT3LG,GADD45A,GALNT10,GCNT3,GLUL,GMNN,HK2,IRF1,JUN,KLF6,LBH,LGALS3,LLGL2,LOX,MET,MRC1,MST1R,MYC,NFKB2,NFKBIA,NR3C1,NT5E,Oasl2,Peg3,PLAGL1,POMK,PPARD,PPFIBP1,PSTPIP1,PYCARD,QTRT2,RAB27A,RANBP1,RCL1,RRP12,SAMHD1,SDC4,SERPINE1,SIRPA,SLC25A32,SLC27A6,SLC3A2,SLC7A1,SOX17,SREBF1,ST3GAL6,STAT5A,TAP1,TEAD2,TGM2,THBS1,TINAGL1,TLE3,TLR2,TRIB1,UPP1,VAPA,VMP1,WEE1,ZFAND2A | 389 (18) |
| prednisolone | NA | chemical drug | NA | 1.07e+00 | 0.0e+00 | ATG16L2,ATG7,BCL2,BCL2L1,BIRC3,BNIP3,BTG1,CEBPD,CFLAR,CRP,CXCL10,EDNRA,FADD,FKBP5,FMO2,GABPB1,Irgm1,IRS2,NFIL3,NR3C1,PIK3CG,SGK1,TGM2,TPO,ZBTB16 | 403 (19) |
| SOX2 | 0.00e+00 | transcription regulator | NA | 1.07e+00 | 0.0e+00 | ACVR1,AFAP1L2,AMOT,AXIN2,BCL2L1,BHLHE40,BMPER,CCND1,CDKN1A,CITED1,CREB3L2,CXCL10,EN1,FBXO15,FGFR4,GAB2,GATA6,GBP4,GPR17,IRF6,IRS1,JARID2,JUN,KDR,KLF4,KLF6,LIMA1,LIMS2,LLGL2,MFSD2A,MIF4GD,MYC,NFKB2,NOG,NRARP,NRP1,Oasl2,OVOL1,PPARG,PROM1,RASGEF1B,RNF43,S1PR5,SEMA6A,SERPINE1,SOX17,TBX3,TEAD1,TEAD2,UST,WNT5A | 444 (23) |
| T-5224 | NA | chemical reagent | NA | 1.07e+00 | 0.0e+00 | ADAMTS1,ARHGAP20,ATF4,CRISPLD2,FKBP5,HAS2,IRS2,JUN,KCTD11,PPP1R15B,PRICKLE2,RASD1,SQLE,TRIB1 | NA |
| CCAR1 | 2.30e-01 | transcription regulator | NA | 1.07e+00 | 0.0e+00 | CEBPD,EPAS1,PPARG,SPHK1 | NA |
| ING4 | -1.70e-01 | transcription regulator | NA | 1.07e+00 | 0.0e+00 | CDKN1A,CXCL10,MYC,NFKBIA | 351 (17) |
| MAPKAPK3 | -1.20e-01 | kinase | NA | 1.07e+00 | 1.0e-02 | BCL2,HSPB8,MKNK1,ZFP36 | NA |
| diethylmaleate | NA | chemical toxicant | NA | 1.07e+00 | 1.0e-02 | CDKN1A,NFKBIA,SLC3A2,SREBF1 | 264 (15) |
| IL37 | NA | cytokine | NA | 1.07e+00 | 2.0e-02 | CCL4,CSF3,CXCL10,IL1RN | NA |
| ICAM1 | -5.00e-02 | transmembrane receptor | NA | 1.07e+00 | 4.0e-02 | CCL4,ITGAL,KLF4,MYC,PROM1,SREBF1 | NA |
| SENP1 | 1.00e-01 | peptidase | NA | 1.07e+00 | 4.0e-02 | GABPB1,MYC,PML,PPARG | NA |
| letrozole | NA | chemical drug | NA | 1.07e+00 | 5.0e-02 | BCL2,CCND1,CDKN1A,MYC | NA |
| EP300 | 3.00e-01 | transcription regulator | NA | 1.06e+00 | 0.0e+00 | ACACB,AGT,AXIN2,BCL2L1,BCLAF1,CA12,CCND1,CDKN1A,CFLAR,CRISPLD2,CSF3,EVI2A,FOXO1,H6PD,HK2,HSD11B1,HSD11B2,HVCN1,IRF6,ITGB7,JUN,KCNIP3,KCTD1,KDR,LEP,MCF2L,MET,MFHAS1,MYC,NDRG1,NFKBIA,NR3C1,PCYT1A,PDK4,PIP5K1B,RAPGEF4,RASA3,RNF157,SDC4,SMAD7,SPHK1,SPSB1,TIPARP,TLR2,TMPRSS2,TPO,TRAF1,Tsc22d3,XRCC6 | 418 (18) |
| IRF4 | -6.10e-01 | transcription regulator | NA | 1.06e+00 | 2.0e-02 | ATF4,BIRC3,BNIP3,CFLAR,CX3CR1,CXCL10,CXCL11,ELL2,IL1RN,INPP4B,IRF1,ITGAL,MYC,RORA,TRAF1 | NA |
| tetradecanoylphorbol acetate | NA | chemical drug | NA | 1.06e+00 | 0.0e+00 | ADAMTS1,ADRB3,AGT,AGTR1,ALDH1A3,ALOX12,BCL2,BCL2L1,BIRC3,BLM,BTG1,BTG2,CBS/LOC102724560,CCL4,CCND1,CCNT1,CDKN1A,CFLAR,CIDEC,CLEC12B,CSF3,CSF3R,CXCL10,CYTH4,DBP,DDIT4,DTL,ECE1,EIF4A1,EN1,EPHA4,ERRFI1,Fam13a,FGF2,FKBP5,GAL,GPC2,GPR34,HAS2,HDC,HK2,HSD11B1,HTR7,IKBKE,IL1RN,IL22RA2,IL6R,INHBB,IRF1,ITGAL,JAK3,JUN,KLF4,KLF6,LBH,LYVE1,MEIS2,MET,MITF,MKNK1,MRC1,MST1R,MYC,NFATC1,NFIL3,NFKB2,NFKBIA,NR3C2,NRP1,PDE3B,PDE4D,PDK4,PER1,PLAGL1,PPARD,PPARG,Ppp1r15a,PRF1,PTPRB,PTPRO,RAB27A,RANBP1,RELB,RGS16,S100A10,SDC4,SERPINE1,SGK1,SLC16A1,SLC7A1,SNAP25,SPHK1,STAR,STX1A,Tchh,TEAD2,THBS1,TLR2,TPO,TRAF1,TRAF4,TRIM45,UPP1,VDR,VIP,ZFP36,ZPBP2 | 403 (15) |
| nelfinavir | NA | chemical drug | NA | 1.05e+00 | 0.0e+00 | ATF4,DENND2D,GPT2,KLF4,LONRF1,LURAP1L,MTHFD2,NFIL3,PLIN4,PPARG,PPP1R15B,SLC6A9,SYBU | NA |
| mitomycin C | NA | chemical drug | NA | 1.05e+00 | 0.0e+00 | BCL2L1,BTG2,CCND1,CDKN1A,GADD45A,JUN,PYCARD,TP53INP1,VMP1,WEE1 | 396 (20) |
| EGR2 | 3.30e-01 | transcription regulator | NA | 1.04e+00 | 0.0e+00 | ACVR1,ANKRD55,BCL2,BHLHE40,CBLB,CDKN1A,CISH,DLG3,EPHA4,FDPS,FGF2,FRAT2,GRIA2,IL1R2,IL6R,JUN,KDR,MAP7,MYC,NDRG1,NFIL3,NFKB2,NRP2,PDE4A,PDE7A,PPT2,RORA,SLC16A1,SLC4A11,Smco4,SQLE,STAR,STAT5A,TFRC,TMEM108,TRAF1,TSC22D1,ZBTB16 | 418 (24) |
| PPARD | 7.40e-01 | ligand-dependent nuclear receptor | NA | 1.04e+00 | 0.0e+00 | ACACB,ADORA1,ALDH9A1,BCL2,BCL2L1,CCND1,CYP2B6,DET1,GPAM,HSD11B2,IFI44L,IKBKE,Irgm1,LPIN2,LRAT,MERTK,MFSD2A,MRC1,PDK4,PER3,PPARD,PPARG,RORA,SAT1,SLC2A10,SREBF1,THBS1,Tlr12 | 289 (23) |
| COPS5 | 1.20e-01 | transcription regulator | NA | 1.04e+00 | 0.0e+00 | AMD1,CCNT1,CDKN1A,CDKN2C,COQ8A,DCK,DDIT4,GTF2F1,INHBB,MYC,POLD1,RANBP9,RCC1,S100A10,SAT1,SLC3A2,SLC7A5,SPHK1,SQLE,TFRC,TOB1,TRAF4,UPP1 | 355 (16) |
| miR-204-5p (and other miRNAs w/seed UCCCUUU) | NA | mature microRNA | NA | 1.04e+00 | 0.0e+00 | ACVR1,ATF4,BCL2,EFNB1,MYC,NOG,PPARG,PTPN11,SNAP25,STX1A | NA |
| CD44 | -4.90e-01 | other | NA | 1.04e+00 | 0.0e+00 | ABCA5,BCL2,BCL2L1,BIRC3,CCL4,CCND1,CD8A,CDKN1A,CIDEC,CX3CL1,CX3CR1,FKBP5,GADD45A,HAS3,IL1R2,IL1RN,JUN,KLF4,LGALS3,LIMS2,MET,MYC,NFKB2,NR1D1,PDK4,PGM2L1,PPARG,SBK1,SDC4,THBS1,TRAF6,WNT5A | 384 (14) |
| vitamin K3 | NA | chemical drug | NA | 1.04e+00 | 0.0e+00 | ATF4,BCL2,CFLAR,EGLN3,HK2,KLF6,MYC,NAMPT | 440 (19) |
| SB203580 | NA | chemical drug | NA | 1.03e+00 | 0.0e+00 | AGT,ANKRD55,BCL2,CCL4,CCND1,CD83,CDKN1A,CEBPD,CHEK2,CRP,CX3CL1,CX3CR1,CXCL10,CXCL11,EDNRB,FOXO1,GADD45A,GBP2,GBP4,GPR88,HAS2,HAS3,HK2,HSD11B2,IL1RN,IRF1,JUN,KCTD1,KDR,MAPK6,MITF,MYC,NAMPT,NFKB2,NFKBIA,P4HA1,PENK,PPARD,PPARG,RBM3,RXRB,S100A10,S1PR5,SERPINE1,SGK1,SLC15A3,STAR,TGM2,THBS1,TLR2,TRAF1,VDR,XYLT1 | 378 (13) |
| MAPK7 | -2.40e-01 | kinase | NA | 1.02e+00 | 0.0e+00 | AACS,ACLY,ADAMTS1,CCND1,CXCL10,FDPS,JUN,KLF4,MYC,NOD1,SQLE,SREBF1,TRAF4 | 426 (23) |
| IL17A | -1.90e-01 | cytokine | NA | 1.02e+00 | 0.0e+00 | BCL2,BCL2L1,CCL4,CCND1,CD83,CEBPD,CRP,CSF3,CX3CL1,CXCL10,FGF2,FMO1,GADD45A,GBP2,HSPB8,IL1RN,IRF1,JUN,LEP,LOX,MERTK,MRC1,MYC,NFATC1,NFKBIZ,NRP1,PGF,PPARG,RGS16,SERPINE1,SGK1,SLC12A3,SPSB1,SREBF1,TLR2,TRAF4,TRAF6 | 386 (14) |
| SPRY2 | 0.00e+00 | other | NA | 1.02e+00 | 1.0e-02 | AXIN2,CDKN1A,CMKLR1,CXCL10,EPAS1,FGFR3,MAP7,MET,MPZL2,SCN1B,TPH1 | 441 (22) |
| IL25 | -3.00e-02 | cytokine | NA | 1.01e+00 | 0.0e+00 | BTG2,CCL24,CIDEC,CSF3,FGF2,IL1R2,KDR,Mt1,SLC7A8 | 414 (17) |
| PRKAA1 | -7.00e-02 | kinase | NA | 1.01e+00 | 0.0e+00 | BCL2,BIRC3,BTG1,CDKN1A,CYP2B6,EGLN3,FGFR2,FKBP5,FOXO3,HIGD1A,Ifi47,IGFBP4,MRC1,NFKBIA,PTPN11,PTPRR,RND3,SLC16A1,STAR,TGM2 | 399 (22) |
| imatinib | NA | chemical drug | NA | 1.01e+00 | 0.0e+00 | BCL2,BCL2L1,CCND1,CDKN1A,CDKN2C,CFLAR,CHD1,CXCL10,EPAS1,FOXO3,GADD45A,Ifi47,IFRD1,Igtp,IRF1,ITGA1,KDR,LSM10,MAPK6,MYC,PIK3CB,POLD1,PTPN11,STAT5A,TCF3,TFRC,VAPA | 353 (20) |
| NAMPT | 6.00e-01 | cytokine | NA | 1.01e+00 | 1.0e-02 | ADRB3,AXIN2,COX5A,CXCL10,FMO3,HPGD,JUN,MITF,NAMPT,RDH16,WNT5A | 323 (19) |
| Ccl2 | -4.40e-01 | cytokine | NA | 1.00e+00 | 0.0e+00 | ADRB3,CCL4,CXCL10,KDR,KLF4,LEP,PPARG,SDC4,TBX3 | 382 (13) |
| PRKCB | 8.00e-02 | kinase | NA | 1.00e+00 | 0.0e+00 | ADRB3,BCL2L1,CCND1,CD83,CDKN1A,FGF2,FOXO1,FOXO3,IRS2,JUN,MYC,NR3C2,RELB,SERPINE1,SREBF1 | 389 (22) |
| 5-O-mycolyl-beta-araf-(1->2)-5-O-mycolyl-alpha-araf-(1->1’)-glycerol | NA | chemical - endogenous non-mammalian | NA | 1.00e+00 | 0.0e+00 | CCL4,CD83,CMKLR1,CX3CR1,CXCL10,CXCL11,NAMPT,NFKB2,NFKBIZ,NT5E,PCSK5,RGS16,RND3,SDC4,SPHK1,TRAF1 | 350 (10) |
| BC-1215 | NA | chemical reagent | NA | 1.00e+00 | 0.0e+00 | TRAF1,TRAF4,TRAF5,TRAF6 | NA |
| fingolimod phosphate | NA | chemical - endogenous mammalian | NA | 1.00e+00 | 0.0e+00 | HAS2,SERPINE1,SPHK1,THBS1 | NA |
| HTT | 3.50e-01 | transcription regulator | NA | 1.00e+00 | 0.0e+00 | ADCY5,AGT,AMD1,ATL2,BCL2,BHLHE40,CA12,CCND1,CDKN1A,CPNE5,CX3CL1,DBP,DLG3,EDNRB,EMC8,EN1,FDPS,FOXO3,GADD45G,GLUL,GPR88,HAP1,HUNK,JUN,Klf16,KLF4,LOX,MEIS2,Mt1,NDUFA5,NFIL3,PENK,PER1,PPARD,PPARG,PPP2R2A,PROM1,RGS16,SGK1,SIRPA,SNAP25,STX1A,STX1B,TCF3,TFRC,TGM2,TYRO3,UBE2G2,VAPA,VIP,VIPR2 | 376 (25) |
| MACROH2A1 | NA | other | NA | 1.00e+00 | 0.0e+00 | ALDH1A3,CDKN1A,CDKN2C,GADD45A,HIF3A,HUS1,IRS1,PPARG,PTPRO,SERPINE1,TBX3 | 263 (16) |
| LAMTOR1 | 2.40e-01 | other | NA | 1.00e+00 | 0.0e+00 | IMPDH2,MTHFD2,NRP1,SQLE | NA |
| phencyclidine | NA | chemical drug | NA | 1.00e+00 | 0.0e+00 | BCL2,BCL2L1,CDON,GAL,HDC | 381 (24) |
| TP53COR1 | NA | other | NA | 1.00e+00 | 1.0e-02 | BIRC3,CFLAR,PLK2,TP53INP1 | 285 (7) |
| WWTR1-CAMTA1 | NA | fusion gene/product | NA | 1.00e+00 | 1.0e-02 | CEBPD,PRND,SERPINE1,TEAD1 | NA |
| olanzapine | NA | chemical drug | NA | 1.00e+00 | 1.0e-02 | BCL2,CYSLTR1,DBP,FGFR2,HDAC5,IL2RB,KCNMB4,LRAT,SLC25A27,TRIM17 | NA |
| PDGF-DD | NA | complex | NA | 1.00e+00 | 2.0e-02 | FGF2,KDR,PGF,Pmaip1 | NA |
| diosgenin | NA | chemical - endogenous non-mammalian | NA | 1.00e+00 | 2.0e-02 | BCL2,CCND1,PTPN11,SERPINE1 | NA |
| TFPI2 | -3.00e-01 | other | NA | 1.00e+00 | 3.0e-02 | BTG2,CCND1,CXCL10,Ppp1r15a | NA |
| TRIM28 | -2.20e-01 | transcription regulator | NA | 1.00e+00 | 4.0e-02 | CCL4,CXCL10,EPAS1,FOXO3,MAP3K5,MITF,WNT5A | NA |
| tosedostat | NA | chemical drug | NA | 1.00e+00 | 4.0e-02 | CBS/LOC102724560,CDKN1A,DDIT4,GADD45A | NA |
| ESRRB | -5.50e-01 | transcription regulator | NA | 1.00e+00 | 4.0e-02 | BCL2,CDKN1A,FBXO15,HK2,SLC6A6 | NA |
| ZNF217 | -9.00e-02 | transcription regulator | NA | 1.00e+00 | 5.0e-02 | CITED1,CXXC4,HOXC6,MPZL2,MYC,RGS20,ST3GAL6 | NA |
| VIP | 1.00e+00 | other | NA | 1.00e+00 | 0.0e+00 | CCL4,CCND1,CEBPD,CXCL10,IRAK2,IRF1,MYC,NFKBIA,PRF1,STAR,TP53INP1,TRAF6,VIP | 404 (18) |
| TGFB2 | 4.30e-01 | growth factor | NA | 9.90e-01 | 1.0e-02 | BHLHE40,CFLAR,FGF2,HAS2,KDR,PDK4,SERPINE1,SPHK1,THBS1,TMEFF1,VDR | NA |
| IL1A | -4.00e-02 | cytokine | NA | 9.90e-01 | 0.0e+00 | ADAMTS1,ALDH1A3,BCL2,BCL2L1,BIRC3,CCL4,CD83,CDKN1A,CSF3,CXCL10,CYP2B6,FGF2,HDC,HSD11B1,HSD11B2,IL1R2,IL1RN,IRF1,JUN,LEP,LOX,MYC,NFKBIA,NFKBIZ,NR3C1,PPARG,S100A10,SERPINE1,TLR2,TOX3,VIP,WNT5A | 394 (15) |
| hyaluronic acid | NA | chemical - endogenous mammalian | NA | 9.90e-01 | 0.0e+00 | BCL2,BCL2L1,CCL4,CD83,CXCL10,JUN,LYVE1,MET,NFKBIA,NOG,PPARG,SERPINE1,SPHK1,TLR2 | 334 (16) |
| CG | NA | complex | NA | 9.80e-01 | 0.0e+00 | ADAMTS1,ADCYAP1R1,APLN,APLNR,ARHGAP20,ATF4,AXIN2,BCL2,BCL2L1,BHLHE40,BLM,BMPR2,BTG1,BTG2,CCND1,CDKN1A,CEBPD,CRISPLD2,CX3CL1,CXCL10,DTL,ELK3,EPAS1,FGL2,FKBP5,GAL,GATA6,GNA15,GREM2,HAS2,HK2,HPGD,HSD11B1,HSD11B2,IGFBP4,IL1R2,INHBB,IRS2,ITGA1,JUN,KCNT2,KCTD11,KLF4,MYC,NR3C2,NRP1,NUCB2,Oasl2,PDE4D,PLXND1,PPARG,PPP1R15B,PRICKLE2,RASD1,RGS20,RORA,S100A10,SDC4,SNAP25,SPAG1,SQLE,SREBF1,STAR,TRIB1,UPP1,XKR8 | 508 (23) |
| S-nitrosoglutathione | NA | chemical toxicant | NA | 9.80e-01 | 0.0e+00 | BCL2L1,BIRC3,CD8A,CDKN1A,CXCL10,IRS1,IRS2,NFKBIA,PPARG,S100A10 | 442 (21) |
| rifampin | NA | chemical drug | NA | 9.80e-01 | 4.0e-02 | AGTR1,AXIN2,C9orf72,CEP70,CXCL10,CYP2B6,FMO5,GATA6,GBP2,HUNK,IFRD1,TLR2 | NA |
| lactacystin | NA | chemical - protease inhibitor | NA | 9.80e-01 | 0.0e+00 | CCND1,CDKN1A,CFLAR,FOXO1,FTL,HSPB8,IFRD1,IRS1,IRS2,MAPK6,NFKBIA,NR3C1,RANBP1,SAT1,SLC3A2,SREBF1,TLR2,VDR | 436 (24) |
| BRD7 | NA | transcription regulator | NA | 9.80e-01 | 0.0e+00 | CDKN1A,FGF2,NDRG1,PIDD1,PYCARD,SERPINE1 | 400 (15) |
| gemfibrozil | NA | chemical drug | NA | 9.70e-01 | 0.0e+00 | CCND1,CRP,GADD45A,MYC,NFKBIA,PCSK5,PPARD,PPARG,SERPINE1 | 405 (21) |
| maslinic acid | NA | chemical - endogenous non-mammalian | NA | 9.70e-01 | 1.0e-02 | BCL2,BCL2L1,CCND1,FOXO3,LEP,PPARD,PPARG,SREBF1,THBS1,WNT5A | 417 (22) |
| mir-24 | NA | microRNA | NA | 9.60e-01 | 3.0e-02 | CDKN1A,JPH2,KDR,MYC,RORA,SERPINE1 | NA |
| GPS2 | 1.60e-01 | transcription regulator | NA | 9.60e-01 | 0.0e+00 | CCL4,CCND1,CDKN1A,CXCL10,FOXO1,IDH1,MYC,NFKBIA,SGK1,TRERF1,XYLT1 | 380 (24) |
| Shc | NA | group | NA | 9.60e-01 | 0.0e+00 | BCL2,BCL2L1,MYC,PPARG | 392 (23) |
| sphingosine-1-phosphate | NA | chemical - endogenous mammalian | NA | 9.50e-01 | 0.0e+00 | ALDH1A3,CCND1,CD83,CSF2RB,CXCL10,FGF2,GATA6,GBP5,HAS2,HSD11B1,IRF6,JUN,KDR,LEP,NRP1,NRP2,SERPINE1,SPHK1,STAR,THBS1 | 395 (18) |
| TNFSF14 | -8.30e-01 | cytokine | NA | 9.40e-01 | 0.0e+00 | BCL2L1,BIRC3,CXCL10,CXCL11,GATA6,Madcam1,NT5E | 327 (17) |
| RBM5-AS1 | NA | other | NA | 9.40e-01 | 0.0e+00 | CCND1,JUN,MYC,PROM1 | 265 (7) |
| BMPR1A | -2.20e-01 | kinase | NA | 9.40e-01 | 5.0e-02 | CDKN1A,EN1,NOG,SERPINE1,STAR | NA |
| GNAQ | -1.20e-01 | enzyme | NA | 9.30e-01 | 0.0e+00 | ADAMTS1,AGTR1,BNIP3,BTG2,CCND1,Clec2d (includes others),CX3CL1,GADD45A,GBP2,HAS2,HIGD1A,HK2,HSPB8,IL1RN,LGALS3,MAFF,MYC,NFIL3,SERPINE1,SGK1,SPHK1,STAR | 339 (19) |
| FOXO1 | 1.15e+00 | transcription regulator | NA | 9.30e-01 | 0.0e+00 | ACLY,AGT,APLN,ATF4,BACH2,BCL2,BIRC3,BNIP3,CCL4,CCND1,CDKN1A,CDKN2C,CEBPD,CFLAR,CXCL10,DDIT4,EDNRB,FDPS,FOXO1,GADD45A,GPAM,GPR17,HUS1,IKZF5,IRS1,IRS2,JUN,KLF4,LEP,LPIN2,LRAT,MYC,NAMPT,NFATC1,NRP2,OVOL1,PDK4,PPARG,PRF1,PTPRB,SEMA6D,SERPINE1,SGK1,SLC25A25,SLC25A30,SQLE,SREBF1,THBS1,TRAF1,TRAF6 | 422 (20) |
| P38 MAPK | NA | group | NA | 9.30e-01 | 0.0e+00 | ANK1,ATG7,BATF2,BCL2,BCL2L1,BNIP3,CCL24,CCND1,CD83,CDKN1A,CEBPD,CFLAR,CSF3,CXCL10,CXCL11,EDNRB,FADD,FGF10,FGF2,HAS2,IL1RN,IRF6,JUN,KLF4,LEP,MITF,MYC,NFATC1,PML,PPARG,RAB7B,RND3,SATB2,SERPINE1,SGK1,TCF3,THBS1,TLR2,TRIB1,TRPC3,VDR,VIP,WNT5A,ZFP36 | 364 (13) |
| ethylene glycol tetraacetic acid | NA | chemical reagent | NA | 9.30e-01 | 2.0e-02 | BCL2,BIRC3,BRAF,CD83,STAR | NA |
| PTX3 | -2.10e-01 | other | NA | 9.30e-01 | 4.0e-02 | CCL4,CX3CR1,JUN,TLR2 | NA |
| DDX25 | 2.90e-01 | enzyme | NA | 9.20e-01 | 0.0e+00 | ACSBG2,BCL2,BCL2L1,CHL1,GLUL,MBNL2,MPZL2,NFKBIA,OTUB2,PAQR5,S100A10,SGMS1,STAR,TLE3,UBE2G2 | NA |
| NFAT5 | -2.50e-01 | transcription regulator | NA | 9.10e-01 | 0.0e+00 | C1QTNF1,CHEK2,CSF3,CXCL10,DDIT4,HECW2,IL1RN,IL6R,IRF1,Irgm1,ITGA1,NFKBIA,PPARD,ROCK2,SGK1,SLC6A6,TLR2,TRAF1 | 358 (17) |
| AICAR | NA | chemical - endogenous mammalian | NA | 9.10e-01 | 0.0e+00 | ATF4,CCND1,CDKN1A,CYP2B6,FOXO1,HK2,HSD11B1,PDK4,PPARD,PPARG,SERPINE1,SREBF1,STAR | 390 (20) |
| lysophosphatidic acid | NA | chemical - other | NA | 9.10e-01 | 0.0e+00 | CCL4,CCND1,CXCL10,FKBP5,JUN,KDR,MYC,PPARG,SERPINE1,SPHK1,WNT5A | 351 (18) |
| ZEB1 | -1.80e-01 | transcription regulator | NA | 9.00e-01 | 0.0e+00 | ESRP2,HK2,ITGA1,LOX,MPZL2,MRC1,NRP1,NRP2,RBM47,S100A10,SERPINE1,THBS1 | 366 (15) |
| 15-deoxy-delta-12,14 -PGJ 2 | NA | chemical - endogenous mammalian | NA | 9.00e-01 | 0.0e+00 | AGTR1,BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,CEBPD,CFLAR,CXCL10,CXCL11,GADD45A,GAL,GATA6,IRF1,JUN,KDR,KLF4,MYC,NFKBIA,NOG,P4HA1,PPARG,RORA,SERPINE1,SOX17,SREBF1,TMPRSS2 | 401 (18) |
| carbon tetrachloride | NA | chemical toxicant | NA | 9.00e-01 | 0.0e+00 | BCL2L1,BIRC3,CCL4,CD38,CDKN1A,CX3CR1,CXCL10,DAGLA,FGFR4,GADD45A,GBP5,JUN,KDR,Mt1,MYC,PPARD,PPARG,PROM1,SKIL,SMAD7,SPHK1 | 457 (21) |
| SIRT1 inhibitor III | NA | chemical drug | NA | 9.00e-01 | 1.0e-02 | ACLY,BCL2,CDKN1A,Pmaip1,SREBF1,TAF1B,TAF1D | NA |
| LGR5 | 6.00e-02 | transmembrane receptor | NA | 9.00e-01 | 0.0e+00 | AXIN2,BCL2L1,GLUL,Gulo,RDH16,SLC16A10 | 267 (7) |
| PTEN | 1.70e-01 | phosphatase | NA | 8.90e-01 | 0.0e+00 | ALDH1A3,ARHGAP10,BCL2,BRPF1,BTG1,BTG2,CA12,CCND1,CDKN1A,CHD1,COQ10A,COX5A,CX3CR1,CXCL10,CXCL11,CYSLTR1,EN1,EPAS1,ERRFI1,FDPS,FGF10,FGFR2,FGFR3,FGFR4,FOXO1,FOXO3,GJA5,GPR157,GPR17,GPR19,GPR75,HDAC5,IFRD1,IRS2,JUN,KDR,KLF6,LGALS3,LRAT,MAFK,MET,MMP15,MPP7,MRC1,MYC,NDRG1,NFATC1,NFIL3,NOD1,NR3C1,OTUB2,PPARG,RAD51D,RCC1,SAT1,SDC4,SERPINE1,SH2B2,SLC46A3,SLC4A11,SLC7A8,SQLE,SREBF1,STAT5A,SURF4,THBS1,TMEM106A,TRAF4,UBA7,UCKL1,ZBTB16 | 435 (24) |
| THPO | NA | cytokine | NA | 8.80e-01 | 0.0e+00 | BCL2L1,BIRC3,CCND1,CIAPIN1,CISH,IRF1,KDR,KLF4,MYC,NFKB2,NFKBIA,NFKBIZ,TAP1,VDR | 381 (16) |
| pyrrolidine dithiocarbamate | NA | chemical reagent | NA | 8.80e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCL4,CX3CL1,CXCL10,GBP2,GDF11,IRF1,MST1R,MYC,NFKBIA,PPARG,PRF1,SERPINE1,TLR2 | 310 (13) |
| Stat6 dimer | NA | complex | NA | 8.80e-01 | 0.0e+00 | BCL2L1,EPAS1,KLF4,PPARD,PPARG,SREBF1 | NA |
| selumetinib | NA | chemical drug | NA | 8.80e-01 | 0.0e+00 | ABL2,CCND1,CDKN1A,EPHA4,FGFR2,FGFR3,FGFR4,FGR,FOXO3,JAK3,JUN,MERTK,MET,MITF,TYRO3 | 391 (20) |
| A2M | 4.20e-01 | transporter | NA | 8.80e-01 | 0.0e+00 | ACLY,ATF4,BCL2,CCL4,CCND1,FOXO1,MAP3K5,SREBF1,WNT5A | 407 (21) |
| vorinostat | NA | chemical drug | NA | 8.80e-01 | 0.0e+00 | ADAMTS1,ATG7,BCL2,BCL2L1,BFAR,BIRC3,BRAF,CCND1,CD8A,CDKN1A,CFLAR,CISH,FADD,HPGD,IRF1,JUN,KLF4,MMP15,MYC,NDRG1,NFKBIA,PLIN4,SREBF1,TRAF1,TRAF4 | 346 (19) |
| ADORA2B | -7.00e-02 | G-protein coupled receptor | NA | 8.70e-01 | 2.0e-02 | BCL2,CCND1,HSD11B2,KLF4,MRC1,SERPINE1 | NA |
| EIF2AK4 | 2.80e-01 | kinase | NA | 8.70e-01 | 3.0e-02 | ATF4,ATG7,BCL2,CIDEC,DDIT4,PPARG | NA |
| IL2RG | -4.50e-01 | transmembrane receptor | NA | 8.70e-01 | 0.0e+00 | ARMCX2,BCL2,CRY1,CXCL10,CXXC5,IKBKE,JUN,MYC,UBA7 | 366 (21) |
| PTHLH | NA | other | NA | 8.60e-01 | 3.0e-02 | ADAMTS1,BCL2,BCL2L1,CCND1,CDKN1A,SERPINE1,SUFU,VDR | NA |
| HDL | NA | complex | NA | 8.60e-01 | 3.0e-02 | AGTR1,CX3CL1,CX3CR1,EGLN3,SREBF1,STAR | NA |
| FOSB | 3.60e-01 | transcription regulator | NA | 8.50e-01 | 2.0e-02 | CCND1,GRIA2,HPGD,PPARG,SERPINE1 | NA |
| CYP1B1 | 2.10e-01 | enzyme | NA | 8.50e-01 | 2.0e-02 | CCND1,CYP2B6,CYSLTR1,FGF10,FLRT3,GDF5,Mt1,MYC,RGS16,SLC46A3,WEE1 | NA |
| F2 | -1.00e-01 | peptidase | NA | 8.40e-01 | 0.0e+00 | BIRC3,CCND1,CDKN1A,CFLAR,CX3CL1,CXCL10,CYP2B6,ECE1,EDNRB,EIF4A1,ELL2,FGF2,HAS2,IGFBP4,JUN,KDR,KLF6,LBH,MAP3K5,MFHAS1,MYC,NFKBIA,NUS1,PGM2L1,RAB3A,RELB,SDC4,SERPINE1,SLC12A7,SLC7A1,THBS1,TRAF1,TRPC3 | 350 (20) |
| TNFRSF9 | -7.00e-02 | transmembrane receptor | NA | 8.40e-01 | 1.0e-02 | BCL2,BCL2L1,BLM,CD83,CLSPN,NFATC1,PRF1,WEE1,XRCC2 | 276 (19) |
| INS | NA | other | NA | 8.40e-01 | 0.0e+00 | ACLY,ADCYAP1R1,AGT,BCL2L1,CBS/LOC102724560,CCND1,CDKN1A,CIDEC,CRP,CUL5,ERRFI1,FADS3,FOXO1,IGFBP4,IRS1,IRS2,JUN,LEP,PLK2,PPARG,RASL12,RDH16,SREBF1 | 432 (22) |
| ARNT | 2.70e-01 | transcription regulator | NA | 8.30e-01 | 0.0e+00 | BCL2,BHLHE40,BMPR2,BNIP3,CSF3,CXCL10,EPAS1,HK2,IL1R2,IRS2,LEP,MYC,NR3C1,PRF1,RANBP1,SERPINE1,TFRC,TIPARP | 395 (20) |
| mir-145 | NA | microRNA | NA | 8.30e-01 | 1.0e-02 | FGF10,FSCN1,GATA6,IRS1,MYC,NFATC1,PDE3B | 358 (15) |
| GSK3B | 2.60e-01 | kinase | NA | 8.30e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,CFLAR,CHD1,IRS2,KDR,MYC,NFATC1,NFKBIZ,RORA,SERPINE1,SLC16A1,SREBF1,TCF7L2,TRAF1 | 360 (21) |
| MTORC1 | NA | complex | NA | 8.20e-01 | 0.0e+00 | ATF4,CCND1,FDPS,HK2,KLF4,MYC,NFIL3,PRF1,SREBF1 | 394 (21) |
| RNF31 | -1.40e-01 | enzyme | NA | 8.20e-01 | 0.0e+00 | ADORA1,CCL4,CCND1,CXCL10,IGFBP4,IL1R2,IL1RN,IL6R,STAR | 414 (16) |
| PDK1 | 2.60e-01 | kinase | NA | 8.20e-01 | 1.0e-02 | CARD11,CD38,FOXO1,HK2,PAG1,PIK3CB,PTPN11,STAT5A | 177 (7) |
| OGT | -3.60e-01 | enzyme | NA | 8.20e-01 | 0.0e+00 | ACLY,BCL2L1,CCND1,CDKN1A,JUN,LBH,MYC,NDUFA5,PCDH20,POU2F3,RGS16,SREBF1,SUFU | 341 (20) |
| lenalidomide | NA | chemical drug | NA | 8.20e-01 | 1.0e-02 | CCND1,CD244,CD38,CDKN2C,CTTNBP2,HS3ST3B1,KLF4,LHFPL2,LIMA1,MYC,NFATC1,NFKBIZ,NRP1,OTUD1,PRF1,RASSF4,RGS16,SPSB1,TCF3,TCF7L2 | 390 (15) |
| FGFR2 | -1.18e+00 | kinase | NA | 8.20e-01 | 0.0e+00 | AMOT,BCL2,BMPER,CCND1,CDKN1A,CITED1,EN1,FGF10,FGFR2,FLRT3,GATA6,GPT2,INHBB,KLB,MYC,NOG,SOX17 | 395 (25) |
| KDM2B | -3.70e-01 | enzyme | NA | 8.20e-01 | 1.0e-02 | CDKN1A,CFLAR,CX3CL1,CXCL10,GATA6,SOX17 | 298 (17) |
| GPR15LG | NA | cytokine | NA | 8.20e-01 | 1.0e-02 | JUN,MAFF,RAB7B,RELB,SREBF1,TRAF4 | NA |
| NORAD | NA | other | NA | 8.20e-01 | 1.0e-02 | BHLHE40,IGFBP4,JUN,SGK1,SSBP3,THBS1 | NA |
| CYP1A2 | -4.00e-02 | enzyme | NA | 8.20e-01 | 1.0e-02 | CCND1,CYP2B6,Mt1,RGS16,SLC46A3,WEE1 | NA |
| lovastatin | NA | chemical drug | NA | 8.10e-01 | 0.0e+00 | ADAMTS1,ATF4,BCL2,BCL2L1,CCND1,CDKN1A,CXCL10,FDPS,IRF1,KLF4,LEP,MYC,PPARD,SDC4,SERPINE1,SREBF1 | 421 (23) |
| NR4A3 | 3.30e-01 | ligand-dependent nuclear receptor | NA | 8.10e-01 | 5.0e-02 | BIRC3,CCND1,CD300C,CDKN1A,FOXO1,NDUFA5,SERPINE1,STAR | NA |
| alvespimycin | NA | chemical drug | NA | 8.10e-01 | 2.0e-02 | BCL2,BCL2L1,CCND1,SREBF1 | NA |
| carbamylcholine | NA | chemical drug | NA | 8.10e-01 | 1.0e-02 | BTG2,CCND1,CDKN1A,ECE1,JUN,MET | 360 (21) |
| HOXA13 | NA | transcription regulator | NA | 8.10e-01 | 1.0e-02 | ACLY,AXIN2,EPHA4,NOG,TBX3,VAPA,WNT5A | NA |
| indomethacin | NA | chemical drug | NA | 8.00e-01 | 0.0e+00 | A3GALT2,ADAMTS1,BCL2L1,BIRC3,BTG2,CCND1,CDKN1A,CSF2RB,Ctla2a,CYP2B6,FGF2,HAS2,LGALS3,LIMA1,MRC1,MYC,PPARD,PPARG,PROM1,RBM3,S100A10,SLC7A5,STAR,TRAF6,UPP1,VDR,XRCC6 | 413 (21) |
| LMO2 | -1.20e-01 | transcription regulator | NA | 8.00e-01 | 0.0e+00 | ABL2,APOBEC1,ATP13A2,AXIN2,BCL2,BCL9,BMPR2,CDKN1A,CDKN2C,DHX58,EGLN3,FGFR3,GBP5,GDF11,GPR34,IRS2,ITGB7,JARID2,LHFPL2,LPIN2,MAP3K5,MGST2,MITF,NDRG1,NPRL3,NT5E,Oasl2,PAG1,PISD,PSTPIP1,SLC16A1,SLC7A8,SLIT1,STAT5A,TAP1,TLR2,TRAF1,TRIM35,VDR | 228 (6) |
| LDB1 | -2.10e-01 | transcription regulator | NA | 8.00e-01 | 0.0e+00 | ABL2,APOBEC1,ATP13A2,AXIN2,BCL2,BCL9,BMPR2,CDKN1A,CDKN2C,DHX58,EGLN3,FGFR3,GBP5,GDF11,GPR34,IRS2,ITGB7,JARID2,LHFPL2,LPIN2,MAP3K5,MGST2,MITF,NDRG1,NPRL3,NT5E,Oasl2,PAG1,PISD,PSTPIP1,SLC16A1,SLC7A8,SLIT1,STAT5A,TAP1,TLR2,TRAF1,TRIM35,VDR | NA |
| bezafibrate | NA | chemical drug | NA | 8.00e-01 | 0.0e+00 | ACACB,APEX1,BNIP3,CRP,JUN,LEP,LGALS3,OGG1,PDK4,PPARG,SERPINE1 | 360 (20) |
| 2-amino-5-phosphonovaleric acid | NA | chemical - other | NA | 7.90e-01 | 0.0e+00 | ADAM19,ADAMTS1,ATF4,BBS12,BVES,CX3CL1,DACT2,FOXO1,GADD45A,GADD45G,HDAC5,IFRD1,JUN,KDR,LBH,LHFPL2,LURAP1,Pmaip1,RASGEF1B,RELB,SLC25A29,Smco4,STOML1,ZNF605 | 210 (7) |
| SREBF2 | -7.00e-02 | transcription regulator | NA | 7.90e-01 | 0.0e+00 | AACS,ACLY,CDKN1A,FDPS,IDH1,IRS2,PCYT1A,PPARG,SQLE,SREBF1,STAR | 430 (22) |
| MECOM | NA | transcription regulator | NA | 7.80e-01 | 0.0e+00 | BCL2L1,CDKN1A,GADD45G,PML,SERPINE1,SKIL,ZFPM2 | 279 (12) |
| Nr1h | NA | group | NA | 7.80e-01 | 0.0e+00 | ACACB,ACLY,AGT,BCL2,CSF3,CXCL10,ECE1,EDNRA,ELOVL4,GPAM,H6PD,ITGAL,MERTK,NFKB2,NFKBIZ,PML,SREBF1,STAR,TAP1,THBS1,ZBTB16 | 395 (22) |
| MAPK1 | -1.00e-01 | kinase | NA | 7.80e-01 | 0.0e+00 | ADH1C,BCL2,CCL4,CCND1,CDKN1A,CISH,COL7A1,CXCL11,EGLN3,FHL2,FOXO1,GBP2,GBP5,GMNN,GRB7,HDC,IL1RN,IRS2,JUN,LGALS3,LOX,MITF,MYC,NFATC1,NRP1,NT5E,OAS2,PML,PPT2,RGS16,SAMHD1,SERPINE1,SPSB1,SUN2,TAP1,TRIM14,VDR,ZNF184 | 418 (21) |
| capsaicin | NA | chemical drug | NA | 7.80e-01 | 0.0e+00 | ATF4,BCL2,BCL2L1,CCND1,LEP,PPARD,PPARG,RXRB,SGK1,TCF7L2 | 400 (23) |
| MAFB | -2.40e-01 | transcription regulator | NA | 7.80e-01 | 1.0e-02 | ALDH1A3,CCL4,CD38,CMKLR1,EGLN3,FOXO1,ITGB7,LGALS3,NFATC1,NUAK1,SLC7A8,ZNF189 | NA |
| GW9662 | NA | chemical reagent | NA | 7.80e-01 | 0.0e+00 | ACLY,AGTR1,BCL2,CD83,CDKN1A,CX3CR1,EGLN3,FADS3,GPAM,IRS2,KDR,KLF4,NR1D1,PPARG,RORA,SREBF1 | 328 (21) |
| JUN | 6.40e-01 | transcription regulator | NA | 7.80e-01 | 0.0e+00 | ALOX12,APEX1,BCL9,BIRC3,BTG1,CCND1,CD244,CDKN1A,CFLAR,CHL1,CSF3,CX3CL1,CXCL10,EIF4A1,EPAS1,EPHX2,FGF2,FOXO3,GADD45A,HK2,HPGD,IGFBP4,IRS2,JUN,KDR,LGALS3,MCF2L,MET,MTHFR,MYC,NAMPT,NDRG1,NFATC1,NFKB2,NFKBIA,NFKBIZ,PENK,PLAGL1,Pmaip1,PPP2R2A,PTPRD,PTPRO,RELB,S100A10,SERPINE1,SGK1,SLC19A1,SLC6A6,SLC7A1,SMAD7,SPHK1,STAR,TCF7L2,THBS1,VDR,WNT5A,XYLT1,ZFP36 | 450 (18) |
| ferric ammonium citrate | NA | chemical drug | NA | 7.80e-01 | 0.0e+00 | FTL,GADD45A,MYC,TFRC | 325 (13) |
| NDRG1 | 8.10e-01 | kinase | NA | 7.70e-01 | 1.0e-02 | BCL2,CCND1,ERRFI1,JUN,MET,MYC,PML,TYK2 | NA |
| TNFSF13B | -2.20e-01 | cytokine | NA | 7.70e-01 | 0.0e+00 | APLN,BCL2,BCL2L1,CCL4,CD83,FGR,FOXO1,HPGD,IL1RN,ITGA1,JUN,LEP,MYC,NAMPT,NFKB2,PGF,PLEK,RELB,SH2B2,THBS1,VDR | 414 (19) |
| SN-38 | NA | biologic drug | NA | 7.60e-01 | 0.0e+00 | BCL2L1,BIRC3,CDKN1A,CHEK2,HK2,MYC,NAMPT | 293 (13) |
| PSMB9 | -4.00e-01 | peptidase | NA | 7.60e-01 | 0.0e+00 | NFKB2,NFKBIA,RELB,TAP1 | 321 (14) |
| NOX1 | -5.00e-02 | enzyme | NA | 7.60e-01 | 1.0e-02 | EPAS1,KDR,NFKBIA,SMAD7 | NA |
| BMP2 | 1.60e-01 | growth factor | NA | 7.60e-01 | 0.0e+00 | BCL2,BCL2L1,BHLHE40,BMPR2,CCND1,CDKN1A,EPHX2,FGF2,FGFR2,FOXO1,HAS2,JUN,KLF4,MYC,NFATC1,NOG,PLXNA2,PPARG,SMAD7,STAR,TGM2,TOB1,VDR,ZBTB16 | 415 (21) |
| IL1B | 2.60e-01 | cytokine | NA | 7.60e-01 | 0.0e+00 | ADAMTS1,AGTR1,ALOX12,ATF4,ATG7,BCL2,BCL2L1,BIRC3,BTG2,CA12,CCL24,CCL4,CCND1,CD244,CD83,CDKN1A,CEBPD,CFLAR,CISH,CRISPLD2,CRP,CSF2RB,CSF3,CSRNP1,CX3CL1,CX3CR1,CXCL10,CXCL11,CYP2B6,CYSLTR1,DBP,DDIT4,EDNRB,EGLN3,EPAS1,ERRFI1,FGF2,FGFR2,FGFR3,FKBP5,FOXO1,GADD45A,GBP2,GBP4,GBP5,GNA15,GRB7,GTF2F1,HAS2,HK2,HSD11B1,HSPB8,IDH1,Ifi47,IFRD1,IGFBP4,IKBKE,IL1R2,IL1RN,IL6R,IRAK2,IRF1,IRS1,IRS2,ITGA1,JUN,KDR,KLF4,LEP,LOX,Mt1,MYC,NAMPT,NFIL3,NFKB2,NFKBIA,NFKBIZ,NR1D1,NRP1,OAS2,OSGIN2,Pcsk1,PELI3,PENK,PPARG,PRF1,RASA3,RELB,RGS16,RIMBP2,RORA,RXRB,S100A10,SAT1,SDC4,SERPINE1,SLC25A25,SMAD7,SNAP25,SPAG1,SREBF1,STAR,STAT5A,TFRC,TGM2,THBS1,TLR2,TOB1,TRAF1,TRAF6,VDR,WNT5A,XYLT1,ZFP36 | 407 (15) |
| estrogen | NA | chemical drug | NA | 7.50e-01 | 0.0e+00 | AGT,BCL2,CCND1,CDKN1A,EPAS1,GAL,IGFBP4,IRS1,JUN,KCNH1,KDR,MYBL1,MYC,NAMPT,NFIL3,PENK,PISD,PLIN4,POLD1,SLC12A3,STAT5A,VDR,ZFP36 | 401 (18) |
| Ca2+ | NA | chemical - endogenous mammalian | NA | 7.50e-01 | 0.0e+00 | ALDH1A3,ALOX12,APEX1,BCL2,BCL2L1,CCND1,CD83,CDKN1A,CEBPD,CRY1,DBP,FGF2,FGFR2,HDC,IL6R,IRF1,IRS2,JUN,KCNG1,KLF4,NDRG1,NFATC1,NFKBIA,NR1D1,PER1,PER3,PPARG,PRDX6,RELB,SERPINE1,SGK1,SLC12A3,STAR,TCF7L2,TRIM10,VDR,VIP | 432 (23) |
| INSIG2 | 1.20e-01 | other | NA | 7.50e-01 | 0.0e+00 | ACLY,ATF4,FDPS,GPAM,SREBF1 | 217 (7) |
| anti-benzo(a)pyrene-diol-epoxide | NA | chemical toxicant | NA | 7.50e-01 | 0.0e+00 | BNIP3,CCND1,CDKN1A,JUN | 367 (20) |
| TAFAZZIN | NA | enzyme | NA | 7.40e-01 | 0.0e+00 | ADAMTS1,CCND1,CD180,CD22,HUS1,IDH1,IGFBP4,IRAK2,Irgm1,IRS1,ITGAL,KLF6,LOX,MET,MRC1,MYC,P4HA1,PDE3B,PLK2,PSMD8,SERPINE1,SIPA1,TELO2,TFRC,THBS1,TRAF1,UPP1 | 341 (20) |
| MAP2K4 | 2.90e-01 | kinase | NA | 7.40e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,CFLAR,CRP,CXCL10,ERRFI1,GADD45A,JUN,PPARD,PPARG,ROCK2,VDR | 380 (21) |
| FABP5 | -1.00e-02 | transporter | NA | 7.40e-01 | 0.0e+00 | CCL4,CUL5,LEP,PPARG,RORA,TRAF1 | 387 (16) |
| UBE2I | -5.00e-01 | enzyme | NA | 7.40e-01 | 0.0e+00 | CCND1,CEBPD,CXCL10,IRF1,MYC,PDK4,PML,PPARG,SGK1,TAP1 | 402 (21) |
| TAS4464 | NA | chemical drug | NA | 7.40e-01 | 0.0e+00 | ATF4,CDKN1A,CFLAR,GADD45A,ITGAL,KLF6,MYC,SLC3A2,SLC7A5 | 345 (12) |
| ADIPOQ | 2.60e-01 | other | NA | 7.40e-01 | 0.0e+00 | ACACB,ACLY,BCL2,CCND1,CDKN1A,CMKLR1,CXCL10,CXCL11,FGFR2,FGFR3,FZD8,IGFBP4,IRS1,KLB,LEP,NFKBIA,PPARD,PPARG,SREBF1,TRAF1,WNT5A | 405 (24) |
| PRMT5 | 5.00e-02 | enzyme | NA | 7.40e-01 | 0.0e+00 | AXIN2,BRAF,CCND1,CXCL10,KLF4,LEP,MYC,PER1,PPARG,PTPRO,SMAD7,SREBF1 | 351 (24) |
| Stat3-Stat3 | NA | complex | NA | 7.40e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,CRP,FTL,MYC,RORA,WNT5A | 399 (20) |
| DKK1 | NA | growth factor | NA | 7.40e-01 | 0.0e+00 | AXIN2,CCND1,CDKN1A,FGF2,LBH,MITF,MYC,PPARG,TBX3,TCF7L2,WNT5A | 422 (25) |
| decitabine | NA | chemical drug | NA | 7.30e-01 | 0.0e+00 | ADAMTS1,ADCY5,AMOT,BCL2,BIRC3,BMPR2,BNIP3,BTG1,CA12,CCND1,CD8A,CDKN1A,CFLAR,CGREF1,COL7A1,CX3CR1,CXCL10,EFNB1,ELOVL4,FBXL7,FGF2,FGFR3,FLRT3,GADD45G,GATA6,HK2,HPGD,HSPB8,ITGA1,KLF4,KLF6,LGALS3,LOX,LRIG1,MET,MYC,NDRG1,NFATC1,NFKBIA,NR3C1,NUCKS1,PDLIM2,PLK2,PPARG,RAB3A,RASSF10,RGMA,RPL9,S100A10,SAT1,SGK1,SIRPA,SLC19A1,SLC7A1,STAR,TFRC,TGM2,THBS1,TLL1,TRIM10,TSC22D1,TYRO3,WNT5A | 455 (22) |
| bucladesine | NA | chemical toxicant | NA | 7.30e-01 | 0.0e+00 | ADAMTS1,ATP7B,AXIN2,BCL2,Cbarp,CCND1,CD38,CD8A,CDKN1A,COQ10B,CXCL10,DCLK3,EGLN3,EPHA4,ERRFI1,FOXO1,GLUL,HAS2,HRH3,HSD11B1,HSD11B2,INHBB,IRAK2,IRF1,IRS2,ITGA1,JAK3,JUN,LEP,MAP3K5,Mt1,MYC,PDE4D,PLAGL1,PLK2,RGS16,SEMA6D,SERPINE1,SMIM3,SNAP25,SOX17,STAR,TINAGL1,TPO,TYRO3,VDR | 329 (19) |
| AURKA | 1.00e-01 | kinase | NA | 7.30e-01 | 2.0e-02 | BCL2L1,CDKN1A,HK2,MYC | NA |
| TP53 | -1.10e-01 | transcription regulator | NA | 7.30e-01 | 0.0e+00 | ACACB,ACLY,ADRA1A,ADRB3,AGTR1,ALDH1A3,ALDH9A1,ANK1,APEX1,APOBEC1,ATF4,ATG7,AXIN2,BCL2,BCL2L1,BCL6B,BHLHE40,BIRC3,BNIP3,BRAF,BTG1,BTG2,CARD11,CCL4,CCND1,CDKN1A,CEBPD,CFLAR,CGREF1,CHEK2,COL7A1,COQ8A,CORO1A,COX5A,CSF3R,CX3CL1,CXCL10,CYSLTR1,DBP,DBT,DCK,DDIT4,DYSF,EDNRA,EIF4A1,EPAS1,FDPS,FGF2,FHL2,FKBP5,FMO1,FOXO1,FOXO3,GADD45A,GADD45G,GATA6,GLUL,GMNN,GNL3,GPD1L,GPR157,GPR17,GPR19,GPR75,HAS2,HDAC5,HDC,HK2,HSPB7,IDH1,IFI44L,IGDCC4,IGFBP4,IL1RN,IRAK2,IRF1,IRS1,Irs3,ITGB7,ITSN1,JUN,KCNG1,KCTD11,KDR,KLF4,KLF6,LGALS3,LIMA1,LIMK1,LOX,LRAT,LTB4R,MAP3K4,MAPK6,MBNL2,MCAT,MED13L,MET,MGST2,MPZL2,MRC1,MST1,MTHFD2,MYBL1,MYC,MYO10,MYO1E,NAMPT,NDRG1,NFKB2,NFKBIA,NRARP,NRP1,NUCKS1,NYNRIN,P4HA1,PHKG1,PIDD1,PIK3CB,PIK3CG,PLK2,Pmaip1,PML,POLD1,PPARD,PPARG,PPFIBP1,PPP1R13B,PRDX6,PROM1,PSMD8,PSTPIP2,PTGER1,PTPN11,PTPRO,PYCARD,RBM3,RELB,RGS16,RLIM,RND3,RPS18,SAT1,SEMA6A,SERPINE1,SGK1,SLC16A1,SLC19A1,SLC6A6,SLC7A5,SMAD7,SMURF1,SPHK1,SQLE,SREBF1,TAP1,TBX3,TCF7L2,TCTN1,TFRC,TGM2,THBS1,TINAGL1,TOB1,TP53I11,TP53INP1,TRAF1,TRAF4,TTC28,UPP1,VAPA,VDR,VMP1,WEE1,ZFP36 | 456 (21) |
| ADCYAP1 | -1.80e-01 | other | NA | 7.30e-01 | 0.0e+00 | ADCYAP1R1,BCL2,BTG2,CCL4,CEBPD,CXCL10,DDHD1,FGFR2,GREM2,IRF1,KLHL40,MYC,NFKBIA,PLAGL1,PRDX6,PTPRR,S100A10,SH2B2,SNAP25,TSC22D1,VIP | 418 (21) |
| CSF1R | 1.20e-01 | kinase | NA | 7.30e-01 | 1.0e-02 | CCND1,CDKN1A,IL22RA2,JUN,MRC1,MYC | NA |
| IL6ST | 1.40e-01 | transmembrane receptor | NA | 7.30e-01 | 2.0e-02 | BCL2L1,CCND1,IL6R,IRF1,JUN,MYC,SERPINE1,VIP | NA |
| USP7 | 1.40e-01 | peptidase | NA | 7.30e-01 | 0.0e+00 | BCORL1,CDKN1A,FKBP5,ITGB7,MYC,PPARG,PPIL4,PTPN11 | 375 (21) |
| CAMP | 2.30e-01 | other | NA | 7.30e-01 | 1.0e-02 | ATG7,BCL2,BCL2L1,CCL4,CD83,CSF3R,CXCL10,FGF2,IL1R2,IL1RN,TLR2 | NA |
| EGR3 | -9.00e-02 | transcription regulator | NA | 7.20e-01 | 0.0e+00 | ANKRD55,BCL2L1,BHLHE40,CBLB,CISH,EFNB1,FRAT2,IL6R,INHBB,JUN,MAP7,MYC,NDRG1,NFIL3,NFKB2,NRP2,PDE4A,PLXND1,PTPN11,RORA,SLC4A11,Smco4,TMEM108,TRAF1,TSC22D1 | 341 (15) |
| celecoxib | NA | chemical drug | NA | 7.20e-01 | 0.0e+00 | ATF4,BCL2,BCL2L1,BFAR,CCND1,CDKN1A,CFLAR,CRP,GADD45A,HUS1,KDR,MET,PPARD,PPARG,SERPINE1,TLR2,TRAF1,TRAF4,WNT5A | 416 (18) |
| mibolerone | NA | chemical drug | NA | 7.20e-01 | 2.0e-02 | AMD1,CCND1,EIF4A1,FDPS,FKBP5,GADD45G,GMNN,JUN,MYC,SQLE,TAX1BP1,TMPRSS2 | NA |
| fenretinide | NA | chemical drug | NA | 7.20e-01 | 0.0e+00 | ATF4,BCL2,CCND1,CFLAR,JUN,LEP,MAPK6,MYC,NFKBIA,PRF1,TRAF1 | 349 (16) |
| troglitazone | NA | chemical drug | NA | 7.20e-01 | 0.0e+00 | ADRB3,AGT,AGTR1,AXIN2,BCL2,BCL2L1,BIRC3,C9orf72,CCND1,CDKN1A,CDKN2C,CEBPD,CEP70,CFLAR,CIDEC,CXCL10,CXCL11,CYP2B6,EGLN3,GADD45A,GBP2,GPAM,HUNK,IFRD1,IRS1,JUN,KLF4,LEP,Madcam1,MYC,NDRG1,NFKBIA,P4HA1,PDE3B,PDK4,PIK3CB,PLIN4,PNPLA8,PPARG,PTPN11,RASD1,SERPINE1,UCK1,WEE1 | 399 (19) |
| IL11 | 2.00e-01 | cytokine | NA | 7.20e-01 | 0.0e+00 | BCL2,BCL2L1,CEBPD,CRP,IRF1,JUN,PPARG,SPHK1,VIP,WNT5A | 338 (17) |
| DDX5 | 3.80e-01 | enzyme | NA | 7.20e-01 | 2.0e-02 | CCND1,CDKN1A,COX5A,JUN,MYC,NDUFA5,WNT5A | NA |
| pilocarpine | NA | chemical drug | NA | 7.10e-01 | 1.0e-02 | AXIN2,HK2,HOMER3,LGALS3,PDK4 | NA |
| APOE | -4.00e-02 | transporter | NA | 7.10e-01 | 0.0e+00 | ALOX12,ATF4,CCL4,CCND1,CSF2RB,CYSLTR1,DAGLA,FKBP5,GLUL,GRIA2,HSD11B1,IL1RN,IL6R,JAK3,JUN,KLF4,LEP,LIMS2,MYC,PIDD1,PPARD,PPARG,SDC4,SEMA6B,SERPINE1,SLC16A1,STAT5A,TLR2,TRAF6 | 369 (18) |
| KLF3 | -1.00e-02 | transcription regulator | NA | 7.10e-01 | 0.0e+00 | ANK1,ATF4,BCL2,CCL24,CIRBP,CX3CL1,CXCL17,GAPT,GRB7,IDH1,IL1RN,ITGB7,KLF12,LILRB3,MCAT,MGST2,NDRG1,NOD1,OGFRL1,PDE7A,PDLIM2,PI4K2B,Proser3,RAP1GAP2,SEC24D,SGK1,TMEM108 | NA |
| ATG7 | 8.70e-01 | enzyme | NA | 7.10e-01 | 1.0e-02 | ACACB,ACLY,ATF4,ATG7,HK2,IKBKE,IRS1,JUN,MYC,NFKBIA,SREBF1 | 375 (22) |
| CLU | -3.00e-01 | other | NA | 7.10e-01 | 0.0e+00 | ATP7B,BCL2,BCL2L1,CCND1,CDKN1A,GBP5,NFKBIA,SAMHD1,SREBF1 | 409 (21) |
| NFKBIA | 9.00e-01 | transcription regulator | NA | 7.10e-01 | 0.0e+00 | AGTR1,BCL2,BCL2L1,BIRC3,BMPR2,BNIP3,BTG2,CCND1,CDKN1A,CEBPD,CFLAR,CSF3,CX3CL1,CXCL10,CXCL11,FGF2,FGFR4,FHL2,FSCN1,GADD45A,GADD45G,GBP2,HK2,HOXD3,IL1RN,IRF1,JUN,LIMA1,LRIG1,MMP15,Mt1,MYC,NFKB2,NFKBIA,PICALM,RASA3,RELB,RGS16,RPS18,SAT1,SDC4,SGK1,TCEAL9,TFRC,TLR2,TRAF1,XRCC6 | 303 (14) |
| BMP7 | -2.30e-01 | growth factor | NA | 7.10e-01 | 0.0e+00 | ACVR1,ADORA1,BMPR2,CDKN1A,CEBPD,CSRP2,CXXC5,EGLN3,GLUL,HSD11B2,IGFBP4,IL1RN,IRS1,KLF4,MAP3K5,MST1R,NDRG1,NOG,PENK,PPARG,PTPRR,SERPINE1,SLC12A7,SMAD7,STAR,TCF3,WNT5A | 311 (18) |
| 12-(3-adamantan-1-yl-ureido) dodecanoic acid | NA | chemical reagent | NA | 7.10e-01 | 0.0e+00 | BCL2,BCL2L1,BCLAF1,BIRC3,CFLAR,FADD,PYCARD,TRAF1,TRAF4 | NA |
| HIVEP1 | -3.00e-02 | transcription regulator | NA | 7.10e-01 | 0.0e+00 | CARD11,IL1R2,IL1RN,IRAK2,NFKB2,NFKBIA,RELB,TRAF1 | 332 (9) |
| methapyrilene | NA | chemical drug | NA | 7.10e-01 | 0.0e+00 | ATF4,BTG2,CBS/LOC102724560,CCND1,CRP,GADD45A,Gulo,IFRD1,MAPK6,Mt1,MYC,Ppp1r15a,PPP2R2A,SLC3A2 | NA |
| NGEF | -4.00e-02 | other | NA | 7.10e-01 | 3.0e-02 | FGFR3,HTR7,IFI44L,KCNJ8,NYNRIN,RAPGEF4,SLC12A3,SLC6A9 | NA |
| methotrexate | NA | chemical drug | NA | 7.00e-01 | 0.0e+00 | ACACB,ALOX12,AMD1,APEX1,BTG2,CCL4,CCND1,CDKN1A,CRP,CXCL10,CXCL11,EPAS1,GPAM,HSD11B1,ITGA1,MET,MITF,Mt1,MYC,NR3C1,PCYT1A,PLD2,PPARD,THBS1,TOB1,TP53INP1 | 413 (18) |
| indican | NA | chemical - endogenous mammalian | NA | 6.90e-01 | 2.0e-02 | AGT,BNIP3,CDKN1A,EGLN3,THBS1 | NA |
| PD173074 | NA | chemical reagent | NA | 6.90e-01 | 0.0e+00 | BCL2L1,CCND1,MAFK,MYC,OVOL1,PGF,PPARD,PPARG,TGM2,TRPV2 | 413 (22) |
| STK11 | -1.70e-01 | kinase | NA | 6.90e-01 | 0.0e+00 | ACVR1,ALDH9A1,BCL6B,CCND1,CDKN1A,COX5A,CSF3,CSF3R,CYP2B6,EIF3A,FGFR2,GADD45A,IL2RB,IMPDH2,KLF12,MAFK,MYC,NFKB2,NOD1,NR1D1,NT5E,PPARG,SERPINE1,SUFU,VIPR2,WNT5A | 386 (23) |
| NR1D1 | -5.90e-01 | ligand-dependent nuclear receptor | NA | 6.90e-01 | 1.0e-02 | ACLY,BNIP3,CRY1,KLB,NAMPT,NR1D1 | 158 (7) |
| lactic acid | NA | chemical - endogenous mammalian | NA | 6.90e-01 | 4.0e-02 | CXCL10,KDR,MRC1,PRF1,SLC16A1 | NA |
| CALCA | NA | other | NA | 6.90e-01 | 0.0e+00 | CARD14,CCL4,CD83,CSF2RB,EGLN3,EPAS1,FGL2,IL2RB,KDR,LIMA1,MYC,NFIL3,NFKBIA,NR3C1,NRP1,PPARG,PRIMA1,SDC4,SERPINE1,TPH1,TRPV2 | 356 (15) |
| GAB2 | 6.70e-01 | other | NA | 6.90e-01 | 0.0e+00 | BCL2,BCL2L1,CCL4,KDR,SERPINE1,SMAD7 | 415 (18) |
| CDK9 | 1.50e-01 | kinase | NA | 6.90e-01 | 1.0e-02 | CDKN1A,FRAT2,MYC,NFKBIA,PDK4,PPARG,WNT5A | 336 (18) |
| dichloroacetic acid | NA | chemical drug | NA | 6.90e-01 | 1.0e-02 | FOXO3,PDK4,Pmaip1,TFEB | NA |
| BRD4 | NA | kinase | NA | 6.90e-01 | 0.0e+00 | BCL2,BCL2L1,BHLHE40,BTG2,CCND1,CDKN1A,ETV6,GADD45A,IL6R,IRF1,ITGA1,JARID2,LOX,MTHFD1L,MYC,SLC19A1,THBS1,TYRO3,WNT5A | 409 (18) |
| pioglitazone | NA | chemical drug | NA | 6.80e-01 | 0.0e+00 | ACE2,ADRB3,AGTR1,ATF4,BCL2,CCND1,CDKN1A,CEBPD,CMKLR1,CXCL10,CYP2B6,EPAS1,HAS2,HPGD,IL1RN,IRS1,IRS2,KLF4,LEP,PDE3B,PPARD,PPARG,PTPN11,RORA,SERPINE1,SREBF1 | 403 (20) |
| LEP | 5.90e-01 | growth factor | NA | 6.80e-01 | 0.0e+00 | ACLY,ADRB3,AGTR1,AXIN2,BCL2,BCL2L1,CCND1,CDKN1A,CRHR2,CRP,CSF3,CXCL10,ECE1,EPHX2,FADD,FGFR2,FMO5,FOXO3,GADD45A,GAL,GPAM,IDH1,IL1R2,IL1RN,IRF1,Irgm1,IRS1,IRS2,JUN,KDR,KLB,LEP,MED13,MYC,NAMPT,NR3C1,Pcsk1,PPARG,PRF1,SERPINE1,SLC16A1,SNAP25,SREBF1,STAR,THBS1,WNT5A,ZFP36 | 428 (25) |
| androgen | NA | chemical drug | NA | 6.70e-01 | 0.0e+00 | ACE2,ADAMTS15,AXIN2,BCL2,BTG2,CA12,CCND1,COL12A1,CRP,CX3CR1,EPS15,FGF10,FGF2,FGFR2,FOXO3,GPT2,JUN,Mt1,MYC,NFKBIA,SDC4,TMPRSS2,VMP1,WNT5A | 343 (19) |
| rituximab | NA | biologic drug | NA | 6.70e-01 | 1.0e-02 | BCL2,BCL2L1,CCL4,CD22,CDKN1A | NA |
| TP73 | -1.20e-01 | transcription regulator | NA | 6.70e-01 | 0.0e+00 | ADAM19,AFAP1,ATG7,BCL2,BHLHE40,BRAF,BTG2,CASS4,CD83,CDC42EP2,CDKN1A,CITED1,CX3CL1,CXCL10,DBP,DDIT4,FGF2,FGFR2,FGFR3,FOXO3,GAB2,GADD45A,GRAMD4,HSPB8,IGFBP4,ITGA1,ITGB7,KIFC3,LBH,LIMA1,LIMK1,MISP,MPZL2,MYC,NDRG1,NRP1,PLK2,PML,RAB7B,SAT1,SDC4,SERPINE1,TAP1,TBX3,THBS1,TP53I11,VDR,VMP1,XRCC6 | 393 (17) |
| pregna-4,17-diene-3,16-dione | NA | chemical - endogenous non-mammalian | NA | 6.60e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CFLAR,MYC,PPARG,SREBF1 | 304 (12) |
| UCN-01 | NA | chemical drug | NA | 6.60e-01 | 2.0e-02 | BCL2,BCL2L1,CCND1,CDKN1A | NA |
| SMURF1 | 6.80e-01 | enzyme | NA | 6.60e-01 | 1.0e-02 | CXCL10,IRF1,SREBF1,TRAF4 | 416 (24) |
| metformin | NA | chemical drug | NA | 6.50e-01 | 0.0e+00 | ARRDC3,ATF4,BCL2,CCND1,CDKN1A,CIDEC,CRP,CYP2B6,DDIT4,GADD45G,Ifi47,IL1RN,IRS1,LEP,MYC,NFKBIA,PHKG1,PLAGL1,PTPN11,SERPINE1,SLC25A30,SREBF1,STAR | 409 (24) |
| liraglutide | NA | biologic drug | NA | 6.50e-01 | 0.0e+00 | ACE2,AGTR1,FGFR2,FGFR3,KLB | 193 (8) |
| CEACAM1 | -5.70e-01 | transporter | NA | 6.50e-01 | 3.0e-02 | CAPN9,CSF3,IL2RB,KDR,LEP | NA |
| H1-2 | NA | other | NA | 6.50e-01 | 0.0e+00 | AXIN2,CCND1,CISH,GADD45A,MYC | 339 (13) |
| BCAP31 | 2.10e-01 | transporter | NA | 6.50e-01 | 0.0e+00 | CXCL10,EDEM1,FGF2,IRF1,IRF6,MRC1,PGF,SREBF1 | 150 (7) |
| DDB1 | 7.00e-02 | other | NA | 6.40e-01 | 0.0e+00 | AXIN2,BTG2,CDKN1A,CEBPD,PPARG,TRIB1,ZFP36 | NA |
| zinc protoporphyrin IX | NA | chemical - endogenous mammalian | NA | 6.40e-01 | 0.0e+00 | CCND1,CDKN1A,FGFR2,MET,PIK3CB | 335 (17) |
| TSHZ3 | -8.00e-02 | transcription regulator | NA | 6.40e-01 | 3.0e-02 | CXXC5,FGF10,HS3ST3B1,KCNG1,LDB2,SPSB1 | NA |
| PTPRJ | 2.00e-02 | phosphatase | NA | 6.30e-01 | 0.0e+00 | CCL4,CEBPD,FGL2,HDC,MERTK,MET,NFKBIZ,PLAGL1,TPO,TSC22D1 | 388 (20) |
| ruxolitinib | NA | chemical drug | NA | 6.30e-01 | 0.0e+00 | BCL2,BCL2L1,CBS/LOC102724560,CCND1,CISH,CXCL10,IL6R,MYC,NAMPT,PYCARD,TYK2 | 379 (16) |
| STX18 | 3.20e-01 | transporter | NA | 6.30e-01 | 3.0e-02 | CEP131,COL7A1,HUS1,IGFBP4,MYO1E,POLD1,POLR2D,SERPINE1,SLC7A1,SUN2 | NA |
| cyclic AMP | NA | chemical - endogenous mammalian | NA | 6.30e-01 | 0.0e+00 | AFAP1L2,BCL2,CCND1,CDKN1A,CEBPD,FGF2,GATA6,IGFBP4,IL1RN,JUN,KDR,LEP,MITF,MYC,NFATC1,PDE4D,PENK,PER1,SERPINE1,SREBF1,STAR,TPH1 | 402 (25) |
| F7 | -4.00e-02 | peptidase | NA | 6.20e-01 | 3.0e-02 | CCND1,GADD45A,MYC,RND3,ZFP36 | NA |
| SOX6 | 3.00e-02 | transcription regulator | NA | 6.20e-01 | 1.0e-02 | CCND1,CDKN1A,FGFR3,MYC,MYH7B | 401 (25) |
| FOXM1 | 2.00e-02 | transcription regulator | NA | 6.20e-01 | 1.0e-02 | ACE2,AXIN2,CCL4,CCND1,CDKN1A,CRP,HSD11B2,IL1RN,JUN,KDR,LOX,MET,MYC,NFKB2,PROM1 | 358 (18) |
| AKT1 | -1.10e-01 | kinase | NA | 6.20e-01 | 0.0e+00 | ACLY,BCL2,BCL2L1,BIRC3,CCL4,CCND1,CDKN1A,CEBPD,CFLAR,CISH,CXCL10,FGF2,FOXO1,HUNK,IRS1,IRS2,KDR,LEP,MYC,NFATC1,NFKB2,PPARG,PROM1,SEMA6D,SERPINE1,SLC3A2,SREBF1,THBS1 | 407 (22) |
| AHR | -3.70e-01 | ligand-dependent nuclear receptor | NA | 6.20e-01 | 0.0e+00 | ACLY,ADAM19,Aox2,BTG2,CARD11,CCND1,CD38,CD8A,CDKN1A,CDKN2C,CDON,CGREF1,COL12A1,CRP,CSF2RB,CX3CR1,CXCL10,CXCL11,CYP2B6,DACT2,DCLK3,EGLN3,EPHX2,FADS3,FGFR2,FMO2,FMO3,GADD45A,GPAM,HK2,HUNK,IL1R2,IL2RB,IRF1,JUN,Mt1,MYC,NT5E,PI4K2A,PLXNA2,PPARG,RDH16,SERPINE1,SLC16A10,SREBF1,THBS1,TIPARP | 360 (20) |
| ESR2 | 5.00e-02 | ligand-dependent nuclear receptor | NA | 6.10e-01 | 0.0e+00 | ADAMTS1,ADCYAP1R1,ADORA1,AGT,ALDH1A3,ANK1,APEX1,APPBP2,ARL4A,BCL2,BCL2L1,BMPR2,BTG2,CA12,CBS/LOC102724560,CCND1,CDKN1A,CDKN2C,CEBPD,COL7A1,CXCL17,CYTH4,ELL2,FADD,FDPS,FGF2,FKBP5,FOXO1,FOXO3,FSCN1,GBP2,GNL3,GPSM2,HOXC6,HPGD,IGFBP4,IMPDH2,INPP4B,IRS2,KCNT2,KDR,KLF4,LOX,MAP7,MPP7,MTHFD2,MYC,NDRG1,NFKB2,NFKBIA,NRP2,OTUB2,PDK4,POLD1,PROM1,RASSF10,RRP12,SDC4,SEC24D,SERPINE1,SGK1,SMAD7,SPHK1,ST8SIA6,TGM2,THBS1,TMPRSS2,TOMM70,TP53I11,TP53INP1,TRIB1,TRIM14,TSC22D1,Tsc22d3,WEE1 | 473 (20) |
| FN1 | 3.00e-02 | enzyme | NA | 6.10e-01 | 0.0e+00 | BCL2,BIRC3,CCL4,CCND1,CD83,CD8A,CDKN1A,CORO1A,CRP,FGF2,IRS1,ITGA1,LIN7C,MYC,NFKBIA,PREB,SDC4,SERPINE1,TGM2,THBS1,TLR2 | 312 (16) |
| quizartinib | NA | chemical drug | NA | 6.00e-01 | 0.0e+00 | CBS/LOC102724560,DDIT4,FGF11,FGF2,GADD45G | NA |
| SMARCA2 | 1.50e-01 | transcription regulator | NA | 6.00e-01 | 0.0e+00 | BCL2,COL7A1,CYLD,FKBP5,KDR,PPARG,RAB27A,Tsc22d3,VDR | 345 (17) |
| piceatannol | NA | chemical - endogenous non-mammalian | NA | 6.00e-01 | 1.0e-02 | BCL2,BCL2L1,BIRC3,CCND1,MYC,NFATC1 | 326 (17) |
| paricalcitol | NA | chemical drug | NA | 6.00e-01 | 4.0e-02 | AGT,BCL2,BCL2L1,PYCARD,VDR | NA |
| KCNIP3 | 8.00e-01 | transcription regulator | NA | 6.00e-01 | 4.0e-02 | CCND1,CX3CL1,EDEM1,SIRPA,STAT5A,TGM2,ZFP36 | NA |
| SOCS3 | 1.70e-01 | phosphatase | NA | 6.00e-01 | 0.0e+00 | BCL2,CCND1,CDKN1A,CXCL10,IL1RN,IRF1,IRS1,IRS2,JUN,LEP,OAS2,SREBF1,STAT5A,TRAF6 | 390 (16) |
| NANOG | NA | transcription regulator | NA | 5.80e-01 | 0.0e+00 | CDKN1A,EN1,GATA6,GDF5,IRF6,JARID2,KDR,KLF4,MYC,OVOL1,PILRB,PRR30,RIF1,SMAD7,SOX17,TBX3,TOB1 | 345 (14) |
| D-glucose | NA | chemical - endogenous mammalian | NA | 5.80e-01 | 0.0e+00 | ACE2,ACLY,ADARB1,ADCY5,AGT,AGTR1,APLN,ATF4,ATG7,BCL2,BCL2L1,BVES,CBS/LOC102724560,CCND1,CDKN1A,CFLAR,CX3CL1,DDIT4,FGF2,GABPB1,GLUL,GPAM,GRIA2,H6PD,HK2,IDH1,INHBB,IRS1,IRS2,ITGA1,JUN,KDR,LEP,MAS1,Mt1,MYC,NAMPT,NR3C1,NUAK1,Pcsk1,PPARD,PPARG,PPP2R2A,PRDX6,PREB,PYCARD,RDH16,RELB,SEMA6A,SERPINE1,SGK1,SLC3A2,SLC7A1,SNAP25,SPHK1,SREBF1,STX1A,SYNPO2,TFRC,TGM2,THBS1,TLR2,Zim1 | 432 (20) |
| EIF2AK2 | -1.30e-01 | kinase | NA | 5.80e-01 | 0.0e+00 | ATF4,BCL2,BCL2L1,BHLHE40,CCND1,CDKN1A,CEBPD,CFLAR,IRF1,IRS2,JUN,MYC,NFKB2,NFKBIA,SAMHD1 | 329 (15) |
| di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone | NA | chemical drug | NA | 5.80e-01 | 0.0e+00 | CCND1,ERRFI1,JUN,MET,MYC,NDRG1 | 340 (18) |
| bromobenzene | NA | chemical toxicant | NA | 5.80e-01 | 0.0e+00 | CDKN1A,CYP2B6,FDPS,FMO1,FMO3,GADD45A,JUN,Mt1,Mt1m/Mt2A,MYC,TSC22D1 | NA |
| tofacitinib | NA | chemical drug | NA | 5.80e-01 | 0.0e+00 | CBLB,CCND1,CISH,CXCL10,HK2,JAK3,MYC,STAT5A | 368 (19) |
| FGF19 | NA | growth factor | NA | 5.80e-01 | 0.0e+00 | ACACB,ACLY,BCL2L1,CCND1,FDPS,GADD45A,IL1RN,LEP,PROM1,RGS16,SCN1B,SGK1,SLC2A5,SQLE,SREBF1 | 347 (23) |
| SFTPA1 | 4.00e-02 | transporter | NA | 5.80e-01 | 0.0e+00 | AMOT,CXCL10,FZD8,KCNMB4,LOX,LRIG1,MRC1,MYC,NAMPT,PDK4,RASD1,SERPINE1 | 423 (17) |
| molybdenum disulfide | NA | chemical reagent | NA | 5.80e-01 | 2.0e-02 | COL12A1,CSF2RB,HSPB7,ITGA11,LBH,LIMS2,MLPH,SIRPA,SYNPO2,THBS1,TINAGL1,TP53I11 | NA |
| oxaliplatin | NA | chemical drug | NA | 5.70e-01 | 4.0e-02 | BCL2,BCL2L1,CCND1,CDKN1A,CFLAR,CHEK2,SAT1 | NA |
| HDAC6 | -4.10e-01 | transcription regulator | NA | 5.70e-01 | 0.0e+00 | ADAMTS1,BCL2,JUN,MST1,MYC,NOG,NR3C1,SERPINE1 | 402 (22) |
| NKX2-3 | NA | transcription regulator | NA | 5.70e-01 | 0.0e+00 | ADAMTSL2,ANKRD55,BATF2,BMPR2,BTG1,CBS/LOC102724560,CD38,CDKN1A,CLEC1A,CSRNP1,CX3CL1,DHX58,FGF2,GBP2,KLF4,Madcam1,REEP1,SMAD7,TAP1,TIPARP,UBA7,ZNFX1 | NA |
| PRKD1 | -5.50e-01 | kinase | NA | 5.60e-01 | 4.0e-02 | ADRB3,BMPR2,CCL4,CCND1,CFLAR,CXCL10,KDR | NA |
| bafilomycin A1 | NA | chemical drug | NA | 5.60e-01 | 0.0e+00 | BCL2L1,CD83,CXCL10,FOXO1,IRS1,NFKBIA,SLC7A1,TFRC | 427 (15) |
| TRAPPC1 | 2.50e-01 | other | NA | 5.60e-01 | 4.0e-02 | ATF4,BCL2,CDKN1A,EDEM1,MAP3K5,PREB,SEC24D,UBE2G2 | NA |
| 3,3’-diindolylmethane | NA | chemical drug | NA | 5.60e-01 | 3.0e-02 | BCL2,BCL2L1,CCND1,CDKN1A,NFKBIA,OAS2,TAP1 | NA |
| FASN | -2.40e-01 | enzyme | NA | 5.60e-01 | 3.0e-02 | ACLY,CIDEC,DDIT4,EDNRB,FOXO1,GPAM,MET | NA |
| PCYT2 | 1.70e-01 | enzyme | NA | 5.60e-01 | 0.0e+00 | CIDEC,GPAM,PISD,PPARG,SREBF1 | NA |
| entinostat | NA | chemical drug | NA | 5.60e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CD83,CDKN1A,CFLAR,CXCL10,LYVE1,MYC,SERPINE1,VDR | 334 (20) |
| XIAP | 3.50e-01 | enzyme | NA | 5.60e-01 | 1.0e-02 | CCND1,CDKN1A,CSF3,MYC,SERPINE1 | 337 (19) |
| nitrofen | NA | chemical toxicant | NA | 5.60e-01 | 2.0e-02 | APLNR,EPAS1,FGFR2,FGFR3,KCNJ8 | NA |
| TREM2 | NA | transmembrane receptor | NA | 5.60e-01 | 3.0e-02 | BCL2,CX3CR1,FGF2,LGALS3,LOX,NFKBIA,PPARG | NA |
| ABL1 | 2.30e-01 | kinase | NA | 5.60e-01 | 4.0e-02 | CCND1,CDKN1A,GADD45A,MYC,VIP | NA |
| FOSL1 | -8.00e-02 | transcription regulator | NA | 5.50e-01 | 1.0e-02 | CCL4,CCND1,CSF3,HPGD,JUN,MET,NRP1,SEMA6D,SERPINE1,THBS1 | 323 (17) |
| ATP-gamma-S | NA | chemical reagent | NA | 5.50e-01 | 0.0e+00 | BTG1,CCL24,CCL4,CD83,CD8A,FOXO3,IL1R2,IL1RN,NRP1,PYCARD,THBS1 | 428 (17) |
| Cdk | NA | group | NA | 5.50e-01 | 0.0e+00 | COX5A,CXCL10,DDIT4,FADD,GADD45A,GADD45G,MYC,TRAF6 | 339 (11) |
| salirasib | NA | chemical drug | NA | 5.50e-01 | 1.0e-02 | ATF4,BHLHE40,BNIP3,CYP2B6,P4HA1,SERPINE1,TGM2 | 320 (15) |
| CD38 | 7.20e-01 | enzyme | NA | 5.50e-01 | 0.0e+00 | BNIP3,CISH,CSF2RB,EGLN3,ELL2,FGL2,GADD45G,GBP2,GBP4,GPAM,HIGD1A,IL1R2,IL6R,ITGB7,LGALS3,NDRG1,NFIL3,NT5E,P4HA1,SLC7A5,TMED5 | 369 (16) |
| CD28 | -2.90e-01 | transmembrane receptor | NA | 5.50e-01 | 0.0e+00 | BCL2,BCL2L1,BHLHE40,BTG1,CBLB,CCL4,CCND1,CFLAR,CISH,FDPS,GBP2,HK2,IRF1,ITGAL,ITGB7,JUN,MYC,NAMPT,NFATC1,NFKB2,NFKBIA,PDE4A,PDE4D,RORA,SLC7A1,SLC7A5,TFRC,THBS1,TOB1,TSC22D1,XRCC6 | 404 (17) |
| Pka catalytic subunit | NA | group | NA | 5.40e-01 | 3.0e-02 | BCL2L1,PENK,STAR,VDR | NA |
| nitroprusside | NA | chemical drug | NA | 5.40e-01 | 1.0e-02 | BCL2,BCL2L1,CFLAR,FOXO1,HSD11B2,MYC,TLR2 | 405 (21) |
| SLC15A4 | -6.70e-01 | transporter | NA | 5.40e-01 | 1.0e-02 | ADAMTS1,CBLB,CXCL10,EDEM1,GBP4,GBP5,LGALS3,MTHFD2,Oasl2,SAT1,TRAM2,TSC22D1 | NA |
| sorafenib | NA | chemical drug | NA | 5.40e-01 | 0.0e+00 | ATF4,BCL2L1,CCND1,CFLAR,CISH,CXCL10,MET,SREBF1 | 355 (22) |
| EIF6 | 7.00e-02 | translation regulator | NA | 5.40e-01 | 0.0e+00 | ACLY,ALG10,ETFBKMT,FADS3,FDPS,GALNT10,GPAM,HK2,IRS1,PIK3AP1,PIK3C2A,PIK3CG,PPARG,TOMM20 | 126 (7) |
| GRIN3A | 4.00e-02 | ion channel | NA | 5.40e-01 | 0.0e+00 | ADAM19,BACH2,CATSPERG,CNTNAP1,CPNE5,CXXC4,IFRD1,LURAP1L,Mt1,MTHFD1L,MTHFD2,TLL1,TMEFF1,TRIM14 | NA |
| grape seed extract | NA | chemical drug | NA | 5.30e-01 | 1.0e-02 | BCL2L1,CCND1,CDKN1A,MYC,NR3C1 | NA |
| AR | -2.10e-01 | ligand-dependent nuclear receptor | NA | 5.30e-01 | 2.0e-02 | Akap17b,AMD1,ARMCX2,ATP13A2,BCL2,BCL2L1,BMPR2,CCL24,CCND1,CDKN1A,CFLAR,COX5A,CXXC5,DDIT4,EDNRA,EDNRB,EPAS1,FGF10,FGFR2,FKBP5,FOXO1,GADD45G,HSPB7,IMPDH2,INPP4B,LRIG1,MTHFD2,MYC,NDRG1,NFATC1,NR3C1,P4HA1,PENK,PER1,RORA,SERPINE1,SGK1,SLC3A2,STAR,SYCE1,THBS1,TMPRSS2,VIP,WEE1,ZBTB16 | NA |
| TCF12 | 6.00e-02 | transcription regulator | NA | 5.30e-01 | 0.0e+00 | CDKN1A,FLT3LG,FOXO1,GLUL,IL2RB,IRF1,ITGB7,JUN,KLF6,PPARG,RORA,VIPR2,XRCC6,ZBTB16 | 212 (10) |
| H89 | NA | chemical drug | NA | 5.20e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CD83,CDKN1A,FGF2,HSD11B2,JUN,MITF,MYC,NFIL3,NFKBIA,PDE3B,PLAGL1,PPARD,SERPINE1,SNAP25,STAR,TPH1 | 390 (24) |
| NPY | -6.00e-02 | other | NA | 5.10e-01 | 0.0e+00 | CBS/LOC102724560,CRY1,FKBP5,GAL,LEP,NAMPT,NR3C1,PER1,TTC7A | 403 (21) |
| E2F3 | 1.80e-01 | transcription regulator | NA | 5.10e-01 | 5.0e-02 | CA12,CCND1,CDKN1A,ECE1,FGF2,FGFR2,LEP,MYC,NPAT,NUCKS1,PPP1R13B,SERPINE1,THBS1 | NA |
| C5 | NA | cytokine | NA | 5.10e-01 | 1.0e-02 | BCL2,BCL6B,CCL4,CCND1,CRP,CSF3,CXCL10,MET,NFKBIA,SERPINE1,SMAD7,ZFP36 | NA |
| LIF | 1.90e-01 | cytokine | NA | 5.10e-01 | 0.0e+00 | BCL2L1,CCND1,CDKN1A,CEBPD,CISH,CRP,CXCL10,GAL,GATA6,GLUL,GPCPD1,HK2,IRF1,JUN,KDR,LEP,MYC,PPARG,RASA3,STAR,VIP,WNT5A | 357 (20) |
| PI3K (complex) | NA | complex | NA | 5.10e-01 | 0.0e+00 | APLN,ATF4,BCL2,BCL2L1,BIRC3,CCL4,CCND1,CCNT1,CDKN1A,CFLAR,CXCL10,DDIT4,FOXO1,HAS3,HK2,IL1RN,JUN,KDR,LEP,MAP3K5,MITF,MRC1,MTHFD2,MYC,NFATC1,NFKB2,NFKBIA,PIK3CG,RASA3,RND3,SAMHD1,SEMA6D,SERPINE1,SGK1,SKIL,SLC12A7,SREBF1,TGM2,THBS1,VIP | 382 (22) |
| luteolin | NA | chemical drug | NA | 5.00e-01 | 1.0e-02 | BCL2,BCL2L1,CCND1,CXCL10,IRS1,JUN,MYC | NA |
| concanavalin a | NA | chemical drug | NA | 4.90e-01 | 0.0e+00 | BCL2,BCL2L1,CCL4,CDKN1A,CFLAR,CSF3,CXCL10,FOXO1,HTR7,IL1RN,IRF1,MET,NR3C1,PENK,SDC4,SIPA1 | 285 (15) |
| OSMR | 5.20e-01 | transmembrane receptor | NA | 4.90e-01 | 0.0e+00 | BCL2,BIRC3,CFLAR,CISH,CXCL10,DHX58,GBP2,GBP4,GBP5,Ifi47,Igtp,IL6R,Irgm1,Oasl2,SREBF1,TRIM35,ZFP36 | 368 (21) |
| SUMO1 | 5.30e-01 | enzyme | NA | 4.90e-01 | 0.0e+00 | CCND1,CIDEC,CXCL10,MYC,NR3C1,TAP1 | 388 (21) |
| mir-130 | NA | microRNA | NA | 4.90e-01 | 3.0e-02 | GADD45A,KDR,KLF4,LRIG1,MRC1 | NA |
| GW3965 | NA | chemical reagent | NA | 4.80e-01 | 0.0e+00 | CCL4,CD38,CHEK2,CIDEC,CRP,CSF3,CX3CR1,CXCL10,EDNRA,FDPS,GADD45G,IL1RN,MERTK,NFKBIA,NR1D1,PDK4,SREBF1,STAR,TRIB1 | 264 (19) |
| TAB1 | -1.40e-01 | enzyme | NA | 4.80e-01 | 0.0e+00 | BIRC3,CDKN1A,CXCL10,GBP2,JUN,NFKBIA,SERPINE1 | 367 (19) |
| Collagen type I (complex) | NA | complex | NA | 4.80e-01 | 3.0e-02 | CCND1,CD83,FOXO3,ITGA1,KDR,MYC,S100A10 | NA |
| AGT | 1.07e+00 | growth factor | NA | 4.80e-01 | 0.0e+00 | A3GALT2,ACE2,ADAMTSL2,ADH1C,AGT,AGTR1,ALDH1A3,ALOX12,ANGPTL8,APLN,BACH1,BCL2,BHLHE40,C1QTNF1,CBS/LOC102724560,CCL4,CCND1,CD300C,CDKN1A,CGREF1,COL12A1,COX5A,CRISPLD2,CRP,CSRP2,CX3CR1,CXCL10,DUSP9,ECE1,EDNRA,EDNRB,ENDOU,ERRFI1,FGF2,FGR,FKBP5,FOXO3,FOXP2,FRAT2,HAS2,IDH1,IGFBP4,INHBB,IRF6,IRS1,IRS2,ITGA1,ITGB7,JUN,KCND3,KCNJ8,KDR,KLF4,LEP,LGALS3,LOX,MAS1,MYBL1,MYC,NAMPT,NDRG1,NFKB2,NFKBIA,OTUD1,PCSK5,PCYOX1L,PGF,PPARG,PPFIBP1,PROM1,PRSS53,RAI1,RGMA,SEMA6A,SERPINE1,SGK1,SLC10A6,SLC12A3,SMAD7,SMURF1,STAR,SUFU,TFRC,THBS1,TTC7A,VIP,WIPF3,ZFP36 | 445 (23) |
| IKBKE | -1.27e+00 | kinase | NA | 4.70e-01 | 0.0e+00 | ACLY,ATF4,BCL2,BIRC3,CCND1,CSF3,CXCL10,IKBKE,MYC,NFKBIA,PDK4,SLC16A1 | 349 (18) |
| TBK1 | 1.30e-01 | kinase | NA | 4.70e-01 | 0.0e+00 | BACH1,BCL2L1,CCL4,CDKN1A,CXCL10,CXCL11,FGL2,HDC,NFKBIZ,OAS2,Oasl2,TLR2,TSC22D1 | 320 (14) |
| NTRK3 | NA | kinase | NA | 4.70e-01 | 1.0e-02 | BCL2L1,BIRC3,CDKN1A,PROM1,SERPINE1 | 400 (19) |
| erlotinib | NA | chemical drug | NA | 4.70e-01 | 0.0e+00 | BCL2L1,CSF3,FGF2,IGFBP4,NFATC1,NFKB2,NFKBIA,PML,RELB,SERPINE1,TLR2,TRAF6 | 424 (17) |
| MAPK9 | 5.00e-02 | kinase | NA | 4.70e-01 | 0.0e+00 | ACLY,BCL2,BIRC3,CDKN1A,CIDEC,EPAS1,FGL2,GADD45A,HDC,JUN,KLF6,MYC,NR3C2,PPARG,SREBF1,VDR,ZFP36 | 400 (19) |
| MAP2K5 | -9.00e-02 | kinase | NA | 4.60e-01 | 0.0e+00 | AACS,ACLY,CCND1,FDPS,JUN,SQLE,SREBF1,THBS1 | 357 (23) |
| cerivastatin | NA | chemical drug | NA | 4.60e-01 | 0.0e+00 | CDKN1A,CYP2B6,ETV6,FDPS,FGF2,ITGAL,JUN,MYC,PPARG,SERPINE1 | 255 (14) |
| methylnitronitrosoguanidine | NA | chemical toxicant | NA | 4.60e-01 | 0.0e+00 | BTG1,BTG2,CCND1,CDKN1A,GADD45A,IRF1,SERPINE1 | 375 (18) |
| BCL3 | -4.70e-01 | transcription regulator | NA | 4.60e-01 | 1.0e-02 | AGT,BCL2,CCND1,CXCL10,IRF1,JUN,NFKBIA,PDK4 | 350 (14) |
| leukotriene D4 | NA | chemical - endogenous mammalian | NA | 4.50e-01 | 0.0e+00 | ADAMTS1,CCL4,CITED1,CYSLTR1,KLF4,NDRG1,PDK4,ZFP36 | 384 (19) |
| CCDC80 | 2.10e-01 | other | NA | 4.50e-01 | 0.0e+00 | AXIN2,BCLAF1,CCND1,LEP,PPARG | 205 (7) |
| lonafarnib | NA | chemical drug | NA | 4.50e-01 | 0.0e+00 | BCL2,BIRC3,CCND1,CFLAR,TRAF1 | 340 (19) |
| AZD8055 | NA | chemical drug | NA | 4.50e-01 | 0.0e+00 | BCL2L1,CXCL10,FOXO1,FOXO3,STAR | 366 (17) |
| LY6E | -4.00e-01 | other | NA | 4.50e-01 | 0.0e+00 | CD83,IRAK2,NFKBIA,RELB,SERPINE1 | NA |
| DMD | NA | other | NA | 4.50e-01 | 1.0e-02 | ARHGAP20,BTG2,CDKN1A,GJA5,IMPA2,MAP7,NOG,PDK4,PHKG1,PIK3CB,PSTPIP2,RAP1GAP2,S100A10,SCN1B,SLC46A3,ST3GAL6,SYNC,TMEM108 | NA |
| Brd4 | NA | kinase | NA | 4.50e-01 | 1.0e-02 | ADAM19,EDNRB,HK2,ITGAL,ITGB7,KDR,KLF4,LGALS3,LOX,MYC,SLC25A25 | 425 (18) |
| NMU | -2.00e-02 | other | NA | 4.50e-01 | 1.0e-02 | ATF4,BTG2,IL1R2,LEP,Mt1 | 325 (12) |
| citarinostat | NA | chemical drug | NA | 4.50e-01 | 1.0e-02 | BTG1,CISH,PDE7A,RCL1,TSC22D1 | NA |
| Collagen type II | NA | complex | NA | 4.50e-01 | 1.0e-02 | CCL24,CRP,CX3CR1,GDF5,IL1RN,NOG | NA |
| FUS-DDIT3 | NA | fusion gene/product | NA | 4.50e-01 | 1.0e-02 | IL6R,LOX,NAMPT,SERPINE1,STX1A,TYK2 | NA |
| cicaprost | NA | chemical drug | NA | 4.50e-01 | 1.0e-02 | ADAMTS1,CSF2RB,FGF2,HAS2,VDR | NA |
| asoprisnil | NA | chemical drug | NA | 4.50e-01 | 2.0e-02 | BCL2,IL2RB,MAP3K5,PRF1,SGK1 | NA |
| HYAL1 | 3.40e-01 | enzyme | NA | 4.50e-01 | 2.0e-02 | BMPR2,FADD,FOXO3,IGFBP4,LOX,TBX3 | NA |
| SIGLEC8 | -5.30e-01 | transmembrane receptor | NA | 4.50e-01 | 3.0e-02 | BNIP3,EGLN3,FTL,P4HA1,RANBP1 | NA |
| pinometostat | NA | chemical drug | NA | 4.50e-01 | 4.0e-02 | CDKN1A,CXXC5,GPT2,PDK4,SMAD7 | NA |
| N-methyl-D-aspartate | NA | chemical drug | NA | 4.40e-01 | 2.0e-02 | BCL2,BCL2L1,FGF2,LIMK1,MYC,SLC7A1,TCF3 | NA |
| RAS | NA | group | NA | 4.40e-01 | 0.0e+00 | BCL2,BCL2L1,BNIP3,CCND1,CDKN1A,CSF3R,CXCL10,GBP2,Ifi47,IRF1,JUN,LRAT,MET,MITF,MYC,PML,PPARD,SERPINE1,SREBF1,TGM2,UPP1 | 348 (16) |
| MUC1 | NA | other | NA | 4.40e-01 | 2.0e-02 | BCL2L1,CCND1,CD83,EGLN3,MRC1,MYC,NFKBIA,NRP1,UPP1 | NA |
| RARA | -3.40e-01 | ligand-dependent nuclear receptor | NA | 4.40e-01 | 1.0e-02 | ACACB,ADH1C,CA12,CCND1,CD38,CDKN1A,CSF3,ELL2,ENY2,FGFR4,IFI44L,IL6R,IRF1,IRF6,JUN,KLF4,MYC,NRP1,PENK,PIK3CG,PLXNA2,RASD1,RASGRP4,RILP,SAMHD1,SOX17,UBA7 | 403 (25) |
| STAT5A | -1.23e+00 | transcription regulator | NA | 4.40e-01 | 0.0e+00 | AXIN2,BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,CFLAR,CISH,CSF3,EGLN3,EPAS1,GADD45A,GADD45G,GCNT3,IL2RB,IL6R,IRF1,MYC,NNT,PPARG,PRF1,QPRT,RORA,S1PR5,SLC2A10,SLC7A8,SREBF1,STAT5A,TRAF1,TRAF4,ZFP36 | 436 (25) |
| APP | 2.70e-01 | other | NA | 4.30e-01 | 0.0e+00 | ADAM19,APPBP2,ARRDC3,ATF4,ATG7,AXIN2,BCL2,BCL2L1,BRPF1,CA12,CALML3,CCL4,CCND1,CDKN1A,CFLAR,COX5A,CSF2RB,CSF3,CXCL10,ELOVL4,EN1,EPAS1,FGF2,FOXO3,GBP2,GBP4,HAP1,Ifi47,Igtp,IRF1,Irgm1,IRS2,ITGA1,ITGAL,JUN,KCND3,LDB2,LGALS3,LHFPL2,LIMK1,MAFF,MBD4,MERTK,MRC1,Mt1,MTHFD1L,MYC,NAMPT,NDUFA5,NFATC1,NOG,NR1D1,NRP1,NRP2,PDXP,PENK,Pmaip1,PPARD,PPARG,PRDX6,PRIMA1,PYCARD,RBM3,SDC4,SERPINE1,SIRPA,SMAD7,SNAP25,STX1B,STXBP4,TLR2,TP53INP1,TPPP,TRAF6 | 443 (21) |
| LMNA | -1.70e-01 | other | NA | 4.30e-01 | 0.0e+00 | BCL2,CD38,COL12A1,GATA6,H3-3A/H3-3B,HAS3,IRF1,Irgm1,JUN,LEP,LYSMD3,MAFF,MBIP,MMP15,MYC,PIP5K1B,PLD2,PPARG,ROCK2,SELENOS,SLC25A42,Smco4,SREBF1,SUN2,TOMM20,UBA7,ZFP36 | 441 (25) |
| HDAC1 | -1.50e-01 | transcription regulator | NA | 4.30e-01 | 0.0e+00 | AGTR1,APEX1,ATG7,AXIN2,CCND1,CDKN1A,FAM107A,GLUL,KDR,Mt1,MYC,NFATC1,NFKBIA,PCYT1A,PPARG,RELB,SERPINE1,SGK1,SMAD7,SREBF1,STX1A,SYCE1,TGM2,VDR | 423 (26) |
| ZNF281 | 4.50e-01 | transcription regulator | NA | 4.30e-01 | 0.0e+00 | BLM,CCL24,CCL4,FANCA,FANCG,GADD45A,GADD45G,PROM1,XRCC2 | NA |
| Ap1 | NA | complex | NA | 4.30e-01 | 0.0e+00 | BCL2L1,CCL4,CCND1,HPGD,IFRD1,JUN,MET,MYC,NDRG1,NOG,NR3C1,Ppp1r15a,RELB,SERPINE1,VDR,VIP,XYLT1 | 424 (23) |
| TRAF2 | 6.00e-02 | enzyme | NA | 4.30e-01 | 1.0e-02 | BIRC3,CFLAR,CXCL10,CYLD,GPR34,IKBKE,NDRG1,ST8SIA6,WEE1 | NA |
| MAP2K6 | -5.80e-01 | kinase | NA | 4.20e-01 | 0.0e+00 | BCL2,CCND1,CD83,CDKN1A,CXCL10,IRS1,IRS2,JUN,RELB,VDR | 423 (23) |
| 9,10-dimethyl-1,2-benzanthracene | NA | chemical toxicant | NA | 4.20e-01 | 1.0e-02 | BCL2L1,CCND1,CDKN1A,GADD45A,JUN,MRC1,SERPINE1 | NA |
| Rxr | NA | group | NA | 4.20e-01 | 0.0e+00 | BCL2,BTG2,CDKN1A,CSF3,CYP2B6,GADD45A,HR,LEP,MYC,PDK4,PPARG,PTPRO,SREBF1,TPH1 | 353 (20) |
| NOX4 | 3.10e-01 | enzyme | NA | 4.20e-01 | 1.0e-02 | AGT,BCL2L1,CDKN1A,EPAS1,HAS2,HK2,SERPINE1 | 320 (17) |
| BAG3 | 1.30e-01 | other | NA | 4.10e-01 | 0.0e+00 | BCL2,BCL2L1,CDKN1A,HK2 | 337 (15) |
| captopril | NA | chemical drug | NA | 4.10e-01 | 0.0e+00 | AGT,CSRP2,Dgke,EPHX2,IL1RN,LGALS3,MRC1,RBM3,S100A10,UPP1 | NA |
| MGA | 7.00e-02 | transcription regulator | NA | 4.10e-01 | 0.0e+00 | ALDH1A3,BNIP3,BTG2,CCND1,CXCL10,EGLN3,EPAS1,GPC2,ITGA1,KCTD11,NDRG1,RALGDS,RNF157,TDRD1,TGM2 | NA |
| butyric acid | NA | chemical - endogenous mammalian | NA | 4.10e-01 | 0.0e+00 | ATP7B,BCL2,BCL2L1,CBS/LOC102724560,CCND1,CD300C,CD83,CDKN1A,CFLAR,CYP2B6,ELK3,GADD45A,GATA6,GBP2,IRF1,IRS1,ITGB7,KLF4,LEP,MYC,NAMPT,NFATC1,NFKB2,NFKBIA,NRP1,OAS2,PPARG,SAT1,SERPINE1,SGK1,SIPA1,SREBF1,STAR,TGM2,TLR2,WEE1,WNT5A | 404 (18) |
| MMP9 | -1.40e-01 | peptidase | NA | 4.10e-01 | 1.0e-02 | BCL2L1,CCND1,CDKN1A,GADD45A,HPGD,MYC,NFATC1,SDC4,THBS1,TRAF5,TRAF6,XRCC6 | 442 (21) |
| PF4 | 1.40e-01 | cytokine | NA | 4.10e-01 | 0.0e+00 | BIRC3,CCL4,CD83,CDKN1A,IL1RN,IRF1,KLF4,NFKB2,NFKBIA,NFKBIZ,SPHK1,VDR | 410 (23) |
| TNFRSF1A | -2.80e-01 | transmembrane receptor | NA | 4.10e-01 | 0.0e+00 | BCL2L1,BIRC3,CCL4,CD38,CD83,CDKN1A,CFLAR,CSF3,CXCL10,JUN,KDR,Madcam1,NHSL2,PPARD,SERPINE1,TFRC,TRAF1 | 363 (15) |
| GDF2 | -6.00e-02 | growth factor | NA | 4.00e-01 | 0.0e+00 | BMPR2,FGFR3,HAS2,HSPB8,LYVE1,MYC,NFKBIA,NOG,NRP1,SLC12A3,SLC3A2,SLC6A6,SLC7A5,SMAD7,SREBF1 | 79 (3) |
| ursolic acid | NA | chemical drug | NA | 4.00e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CDKN1A,EIF2S2,FGF2,HK2,LEP,MYC,NR3C1,PPARG,S1PR5,SLC6A9 | 423 (22) |
| sorbitol | NA | chemical - endogenous mammalian | NA | 4.00e-01 | 0.0e+00 | BCL2L1,CDKN1A,ERRFI1,SGK1 | 415 (24) |
| arsenic trioxide | NA | chemical drug | NA | 4.00e-01 | 0.0e+00 | ATF4,BACH1,BCL2,BCL2L1,BNIP3,CCND1,CDKN1A,CFLAR,EPAS1,FDPS,IFRD1,IRF1,MAPK6,MYC,NFKBIA,PIK3CB,PML,POLD1,PPARG,PTPN11,SKIL,SQLE,SREBF1,TFRC,VAPA,VDR | 386 (18) |
| isotretinoin | NA | biologic drug | NA | 4.00e-01 | 0.0e+00 | AGTR1,ALDH1A3,BCL2,BCL2L1,CD38,CDKN1A,HPGD,IRF1,NFKB2,TFRC,TLR2 | 467 (26) |
| mir-15 | NA | microRNA | NA | 4.00e-01 | 0.0e+00 | ACACB,ACLY,ALDH1A3,BCL2,CCND1,FGF2,FOXO1,PPARG,RORA,SREBF1,WEE1 | 358 (17) |
| CD3 | NA | complex | NA | 3.90e-01 | 0.0e+00 | ATF4,BCL2,BCL2L1,BIRC3,BTG1,CCL4,CCND1,CD83,CD8A,CFLAR,CISH,CORO1A,COX5A,CXCL10,ELK3,FDPS,FMO3,FTL,GABPB1,IL2RB,IRF1,ITGB7,JAK3,JUN,MST1,MTHFD2,MYC,NAMPT,NFATC1,NFKBIA,NFX1,NR3C2,PDE4A,PDE4D,PLEK,PPARG,PRF1,RBM3,RELB,RORA,SLC7A1,TCF3,TFRC,TGM2,THBS1,TLR2,TRAF1,TRAF5,TRAF6,VIPR2,WEE1,XRCC6,ZFP36 | 389 (17) |
| MSTN | -4.40e-01 | growth factor | NA | 3.90e-01 | 4.0e-02 | CDKN1A,GDF11,INHBB,LEP,NFATC1,PPARG,STAR | NA |
| PRKACA | -1.20e-01 | kinase | NA | 3.90e-01 | 5.0e-02 | Akr1c14,CCND1,LEP,MYC,PENK | NA |
| IHH | -1.90e-01 | enzyme | NA | 3.90e-01 | 0.0e+00 | CCND1,CXCL10,EN1,FGFR2,FGFR3,GPR34,KDR,MET,MRC1,PDK4,PLIN4,TCF7L2 | NA |
| RELA | -7.00e-02 | transcription regulator | NA | 3.80e-01 | 0.0e+00 | AGT,BACH2,BCL2,BCL2L1,BHLHE40,BIRC3,BTG2,CBS/LOC102724560,CCND1,CDKN1A,CRP,CX3CL1,CXCL10,CXCL11,CYP2B6,EPAS1,FGF10,FGF2,FMN2,FSCN1,HAS2,HSD11B2,IKBKE,IL1RN,INPP4B,IRF1,JUN,KCNT2,Madcam1,MST1R,MYC,NAMPT,NFATC1,NFKB2,NFKBIA,OAS2,Pmaip1,PPARG,PRDX6,RELB,SDC4,SLC2A5,SMAD7,SREBF1,STAR,STAT5A,TAP1,TGM2,TLR2,TPO,TRAF1 | 400 (14) |
| IL15 | -4.60e-01 | cytokine | NA | 3.80e-01 | 0.0e+00 | ATF4,BCL2,BCL2L1,BTG1,CBLB,CCL4,CCND1,CD244,CD38,CD83,CD8A,CDKN1A,CISH,CMKLR1,CORO1A,CSF3,CX3CR1,CXCL10,ELK3,FLT3LG,FMO3,GABPB1,HK2,IL2RB,IRF1,ITGB7,JUN,LEP,MKNK1,MST1,MYC,NFIL3,NFKBIA,NR3C2,PLEK,PPARD,PRF1,RGS16,SERPINE1,SLC16A1,SMAD7,TFRC,TLR2,UPP1,VDR,ZFP36 | 438 (18) |
| STAT1/3/5 dimer | NA | complex | NA | 3.80e-01 | 0.0e+00 | BCL2L1,CEBPD,CISH,CRP,EPAS1,IRF1,VIP | NA |
| IOX2 | NA | chemical reagent | NA | 3.80e-01 | 0.0e+00 | BNIP3,CARD11,JUN,LOX,NDRG1,P4HA1,PPP1R3G | NA |
| VH032 | NA | chemical reagent | NA | 3.80e-01 | 0.0e+00 | BNIP3,CARD11,JUN,LOX,NDRG1,P4HA1,PPP1R3G | NA |
| mir-25 | NA | microRNA | NA | 3.80e-01 | 0.0e+00 | CDKN1A,EDNRB,FGF2,GADD45A,MITF,TBX3,TOB1 | 368 (18) |
| daporinad | NA | chemical drug | NA | 3.80e-01 | 0.0e+00 | AXIN2,BHLHE40,LRIG1,NAMPT,PROM1,SERPINE1,VDR | 363 (12) |
| ARHGAP21 | -7.00e-02 | other | NA | 3.80e-01 | 0.0e+00 | CXCL10,FGL2,HDC,IRF1,MERTK,NFKBIZ,TSC22D1 | NA |
| HOXA3 | -2.80e-01 | transcription regulator | NA | 3.80e-01 | 0.0e+00 | EPAS1,EVI2A,PIK3CG,PLEK,PLXND1,PSTPIP1,SOX17 | NA |
| ziritaxestat | NA | chemical drug | NA | 3.80e-01 | 1.0e-02 | ALDH1A3,DDIT4,GBP2,HDAC5,OAS2,SGK1,STAC | NA |
| BAPTA-AM | NA | chemical reagent | NA | 3.80e-01 | 1.0e-02 | CDKN1A,CISH,CXCL10,CXCL11,JUN,NFATC1,TRPC3 | NA |
| KLF11 | -8.00e-02 | transcription regulator | NA | 3.80e-01 | 3.0e-02 | ADAMTS1,AGT,BCL2,ITGA1,LOX,MYC,PDK4,PPARG,SERPINE1,SMAD7,THBS1 | NA |
| TOPBP1 | -1.70e-01 | other | NA | 3.80e-01 | 0.0e+00 | BLM,CDKN1A,COQ8A,GADD45A,MYC,Pmaip1 | 378 (17) |
| Growth hormone | NA | group | NA | 3.70e-01 | 0.0e+00 | AGT,BCL2,CCND1,CEBPD,CISH,CRHR2,CX3CL1,FDPS,FGFR3,FKBP5,IRF1,JUN,MYC,NAMPT,NFKBIA,NR1D1,PDK4,PIK3C2B,PLK2,PPARG,RAB3A,SGK1,STAT5A,TSC22D1 | 393 (18) |
| fingolimod | NA | chemical drug | NA | 3.70e-01 | 3.0e-02 | BCL2,BCL2L1,CCL4,CDKN1A,CXCL10,MITF,SERPINE1,SPHK1 | NA |
| CASR | NA | G-protein coupled receptor | NA | 3.70e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CISH,CXCL10,CYP2B6,GADD45A,GADD45G,GATA6,ITGB7,LBH,NFATC1,PDLIM2,PPARG,TLR2,VDR | 398 (21) |
| buthionine sulfoximine | NA | chemical drug | NA | 3.70e-01 | 0.0e+00 | BCL2,BCL2L1,HSD11B2,NFKBIA,NR3C2,SERPINE1 | 374 (25) |
| HEXIM1 | -2.50e-01 | transcription regulator | NA | 3.70e-01 | 2.0e-02 | ACE2,CCND1,CDKN1A,FGF2 | NA |
| resiquimod | NA | chemical drug | NA | 3.70e-01 | 0.0e+00 | ANKRD33B,ATF4,BCL2,CCL24,CCL4,CD180,CD22,CD83,CMTM8,CSF3,CXCL10,CXCL11,DHX58,FGF2,HDAC5,IFI44L,IGFBP4,IRAK2,IRS2,JAK3,JUN,LGALS3,NAMPT,NFKB2,NFKBIA,NFKBIZ,OAS2,PDE4D,PIK3CG,PML,PRDX6,PSMD8,PYCARD,RELB,SEMA4B,TFRC,TLR2,TRAF6,XRCC6 | 389 (14) |
| thyroid hormone | NA | chemical - endogenous mammalian | NA | 3.60e-01 | 1.0e-02 | AGT,ATF4,BTG2,CCND1,CDKN1A,FDPS,HR,IGFBP4,LEP,MYC,PER1,PML,S100A10,SEMA6B,VIP | NA |
| EBI3 | -7.00e-01 | cytokine | NA | 3.60e-01 | 1.0e-02 | CCL24,GADD45G,GBP2,IRF1,MYC,NFATC1,TAP1 | NA |
| calcimycin | NA | chemical reagent | NA | 3.50e-01 | 0.0e+00 | AGTR1,AMD1,CD83,DDIT4,FGF2,JUN,MTHFR,MYC,PPARG,SERPINE1,STAR,TLR2,TPO | 416 (19) |
| TCF3 | -8.00e-01 | transcription regulator | NA | 3.50e-01 | 0.0e+00 | ACACB,ARHGAP4,AXIN2,BACH2,CDKN1A,CDKN2C,CGREF1,CREB3L2,DCK,EDEM1,FGFR2,FGFR3,FLT3LG,FOXO1,GADD45A,GLUL,GPAM,HSD11B1,IL2RB,IRF1,ITGB7,JUN,KLF4,KLF6,MYC,NFIL3,PML,PPARG,RASSF4,RGS16,RORA,SEC24D,SLC7A5,TCEAL9,TCF3,TMEFF1,TRAF5,VIPR2,XRCC6,ZBTB16 | 204 (11) |
| INHA | 4.00e-02 | growth factor | NA | 3.40e-01 | 0.0e+00 | ADAMTS1,ADAMTSL2,BCL2,CFLAR,FGFR4,HAS2,IGFBP4,INHBB,MYC,SERPINE1,SGK1,SMAD7,STAR,TP53INP1 | 231 (12) |
| ACACB | -6.80e-01 | enzyme | NA | 3.40e-01 | 0.0e+00 | ACACB,ACLY,LEP,PPARG,SREBF1 | 346 (16) |
| MYB | NA | transcription regulator | NA | 3.40e-01 | 0.0e+00 | AXIN2,BCL2,BCL2L1,BHLHE40,BIRC3,CCND1,CSF3,FOXO1,HK2,IKBKE,JUN,KDR,KLF4,MYC,NFKB2,PRND,SDC4,SPHK1 | 320 (15) |
| MIF | NA | cytokine | NA | 3.40e-01 | 1.0e-02 | ATG7,BCL2,BCL2L1,CCL4,CCND1,CRP,CXCL10,HAP1,HSD11B2,JUN,MET,OAS2,SREBF1 | NA |
| octanoic acid | NA | chemical - endogenous mammalian | NA | 3.40e-01 | 0.0e+00 | LEP,PPARD,PPARG,SREBF1 | NA |
| NRIP1 | 4.80e-01 | transcription regulator | NA | 3.40e-01 | 1.0e-02 | ACACB,CCND1,CDKN1A,HAS2,OTUB2,PDK4,SLC16A10,STAR | 483 (24) |
| prostaglandin A1 | NA | chemical - endogenous non-mammalian | NA | 3.40e-01 | 1.0e-02 | BCL2,BCL2L1,CDKN1A,NFKBIA | NA |
| PAX5-ELN | NA | fusion gene/product | NA | 3.30e-01 | 0.0e+00 | CD180,CD38,EPAS1,IGSF10,IL2RB,IRS1,KDR,PLK2,SEMA6D | NA |
| NLRX1 | -1.80e-01 | other | NA | 3.30e-01 | 0.0e+00 | AGT,BIRC3,FADD,IRF1,NFKB2,NFKBIA,NOD1,RELB,TRAF6 | 298 (11) |
| STAR | -6.40e-01 | transporter | NA | 3.30e-01 | 0.0e+00 | AGT,COQ8A,FGF2,NR1D1,NUAK1,PNPLA8,SLC25A33,TGM2,TP53INP1 | NA |
| LCK | -2.50e-01 | kinase | NA | 3.30e-01 | 0.0e+00 | BCL2L1,CISH,IL2RB,IRF1,ITGAL,JUN,MYC,PPARG,UTP14A | 373 (21) |
| SLC13A1 | NA | transporter | NA | 3.30e-01 | 2.0e-02 | ACLY,EDEM1,GBP2,GPAM,HK2,Igtp,MRGPRX3,Mt1,SLC16A1 | NA |
| CCL5 | -3.90e-01 | cytokine | NA | 3.30e-01 | 2.0e-02 | ATF4,CCL4,HDC,NAMPT,SGK1,SQLE,THBS1,ZFP36 | NA |
| thapsigargin | NA | chemical toxicant | NA | 3.30e-01 | 0.0e+00 | ATF4,BCL2L1,BIRC3,CCND1,CD83,CDKN1A,CFLAR,CREB3L2,CXCL10,DDIT4,EDEM1,ERRFI1,EVI2A,GADD45A,HDC,JUN,KLF4,LBH,LRIG1,MET,MTHFR,MYC,NFIL3,NFKBIA,SELENOS,SGK1,SREBF1,TGM2,THBS1,TLR2,UPP1 | 435 (23) |
| isobutylmethylxanthine | NA | chemical toxicant | NA | 3.30e-01 | 0.0e+00 | ACLY,AGT,APLN,BMPR2,CCND1,CDKN1A,CEBPD,CIDEC,IDH1,ITGA1,JUN,KLF4,MERTK,MITF,Mt1,MYC,PDE3B,PDE4D,PDK4,PPARD,PPARG,ROCK2,SERPINE1,SGK1,SREBF1,THBS1,TYRO3 | 432 (20) |
| cyclophosphamide | NA | chemical drug | NA | 3.30e-01 | 1.0e-02 | BCL2,Ctla2a,CYP2B6,FADD,IL1R2,LGALS3,MYC,RBM3,THBS1,UPP1 | NA |
| RAB2A | 2.50e-01 | enzyme | NA | 3.20e-01 | 0.0e+00 | ACLY,CIDEC,PLIN4,PPARG,SREBF1 | NA |
| phytohemagglutinin | NA | chemical drug | NA | 3.20e-01 | 0.0e+00 | AGT,BTG1,CCL4,CCNT1,CD83,CXCL10,FGFR3,FGR,GAB2,HPGD,IL1R2,JAK3,MEIS2,MET,NT5E,PGF,PRF1,RCC1,SPHK1,STAT5A,TEAD1,TRAF1,TRAF5,TRAF6,VGLL4 | 426 (17) |
| TCF/LEF | NA | group | NA | 3.20e-01 | 0.0e+00 | CCND1,JUN,MITF,MYC,SERPINE1 | NA |
| ionomycin | NA | chemical reagent | NA | 3.10e-01 | 0.0e+00 | BCL2,BCL2L1,CIDEC,CSF3,CXCL10,GBP4,HK2,HTR7,ITGAL,JARID2,MYC,NFATC1,NFIL3,NRP1,PPARG,PRF1,SGK1,SLC3A2,SLC6A6,TLR2,TRAF5,ZBTB16 | 381 (21) |
| GATA6 | 9.00e-01 | transcription regulator | NA | 3.10e-01 | 1.0e-02 | ASPA,BMPR2,BRAF,CDKN1A,CITED1,COX5A,FGF2,GATA6,IRF6,LYVE1,MRC1,MYC,OVOL1,PPARG,SOX17,STAR,TBX3 | NA |
| EWSR1-FLI1 | NA | fusion gene/product | NA | 3.10e-01 | 0.0e+00 | BCL2L1,BIRC3,CCND1,CDKN1A,EDNRA,HPGD,NFKBIZ,NUAK1,PTPRO,SAMD5,SERPINE1,SYNPO2,THBS1 | 160 (7) |
| PPP1R1B | 9.00e-02 | phosphatase | NA | 3.10e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CFLAR,MYC | 363 (21) |
| peptidoglycan | NA | chemical - endogenous non-mammalian | NA | 3.00e-01 | 2.0e-02 | CCL4,CORO1A,CSF3,CXCL10,CYLD,IL1RN,IRF1,TLR2,TRAF6,VDR | NA |
| trichostatin A | NA | chemical drug | NA | 3.00e-01 | 0.0e+00 | ADAMTS1,AGT,AMOT,APPBP2,BCL2,BCL2L1,BTG1,CA12,CCND1,CDKN1A,CFLAR,CGREF1,CISH,CSF3R,CXCL10,EFNB1,FGF2,FGFR3,FGFR4,FLRT3,FOXO1,FTL,GADD45A,GADD45G,GATA6,GDF11,GRIA2,HSD11B2,IDH1,IGFBP4,IRF1,ITGA1,KDR,KLF4,LIMA1,LMX1A,LOX,MET,MRC1,MST1,MYC,NDRG1,NFATC1,NFKB2,NFKBIA,NRP1,NUCKS1,PCDH20,PCYT1A,PENK,PLAGL1,PLK2,PPARG,PRDX6,RAB3A,RCL1,RELB,RLIM,RND3,S100A10,SAT1,SERPINE1,SGK1,SLC7A1,SLC7A8,SPHK1,SREBF1,STAR,TCF7L2,TGM2,THBS1,TLR2,TMPRSS2,TYRO3,WNT5A | 431 (18) |
| phenobarbital | NA | chemical drug | NA | 3.00e-01 | 3.0e-02 | BCL2,CCND1,CDKN1A,CYP2B6,OGG1,SAT1,SREBF1,TRPC3 | NA |
| RPS6KB1 | 4.10e-01 | kinase | NA | 2.90e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CDKN1A,CFLAR,CXCL10,IRS1,SERPINE1 | 409 (23) |
| JARID2 | 9.80e-01 | transcription regulator | NA | 2.90e-01 | 2.0e-02 | CCND1,CDKN1A,PPARG,SREBF1 | NA |
| IL1 | NA | group | NA | 2.90e-01 | 0.0e+00 | ADAMTS1,BCL2,BHLHE40,CCL4,CDKN1A,CEBPD,CRP,CSF2RB,CSF3,CXCL10,CXCL11,CYP2B6,HSD11B1,IL1R2,IL1RN,IL2RB,IRF1,JUN,KLF6,LEP,LOX,LRAT,MYC,NRP2,PPARG,RELB,RORA,SDC4,SERPINE1,SPHK1,SREBF1,TGM2,TLR2,WNT5A | 374 (14) |
| MYF6 | -5.50e-01 | transcription regulator | NA | 2.90e-01 | 0.0e+00 | ACACB,APLN,CCL24,CDKN1A,CX3CL1,CXCL10,FGF2,GDF11,IL1RN,NAMPT,SERPINE1,THBS1,TPO | NA |
| SMO | -4.40e-01 | G-protein coupled receptor | NA | 2.80e-01 | 0.0e+00 | BCL2,CCND1,CXXC4,DIXDC1,HSD11B2,MYC,NFATC1,NOG,NRP2,PPARG | 378 (22) |
| JINK1/2 | NA | group | NA | 2.80e-01 | 4.0e-02 | AXIN2,BCL2,FOXO1,SREBF1 | NA |
| DLL4 | -9.00e-02 | other | NA | 2.80e-01 | 0.0e+00 | KDR,LYVE1,MYC,NFKB2,NRARP,RELB,TCF7L2 | 195 (11) |
| TLR7/8 | NA | group | NA | 2.80e-01 | 1.0e-02 | BCL2,CFLAR,NFKBIA,NFKBIZ,RGS20,VDR | 376 (12) |
| YY1 | 9.00e-02 | transcription regulator | NA | 2.70e-01 | 0.0e+00 | ATF4,BCL2L1,BTG2,CD22,CDKN1A,CDKN2C,DDIT4,FDPS,GADD45G,HAS2,IL1R2,KDR,KLF4,MYC,NFKBIZ,NR3C1,PLAGL1,Pmaip1,RLIM,RND3,STAR,TBC1D14,TGM2,TP53INP1,TPH1 | 417 (21) |
| PLAUR | 1.50e-01 | transmembrane receptor | NA | 2.70e-01 | 1.0e-02 | BCL2L1,CCND1,JUN,KDR,MYC,XRCC6 | NA |
| plicamycin | NA | chemical drug | NA | 2.70e-01 | 0.0e+00 | CDKN1A,CX3CL1,FOXO3,HSD11B2,IGFBP4,KDR,MET,MST1R,PROM1,SERPINE1,SNAP25,STX1A,VDR,XYLT1 | 396 (24) |
| CGA | NA | other | NA | 2.70e-01 | 4.0e-02 | ADAMTS1,CCND1,FOXO1,HR,IRAK2,SGK1,STAR,STAT5A,TP53INP1 | NA |
| FOXP3 | -2.00e-01 | transcription regulator | NA | 2.70e-01 | 0.0e+00 | BCL2,CDKN1A,CYSLTR1,FGL2,GBP2,GBP4,IGFBP4,IL2RB,IL6R,JUN,LGALS3,LTB4R,NFIL3,NRP1,NT5E,PCYT1A,PDE3B,PLAGL1,Pmaip1,POLD1,PPARG,PRF1,SDC4,SMAD7,TGM2,TRAF6,USP21 | 421 (19) |
| carbon monoxide | NA | chemical - endogenous mammalian | NA | 2.60e-01 | 1.0e-02 | ATF4,BCL2,CCL4,CDKN1A,CFLAR,FADD,LEP,SERPINE1 | 374 (20) |
| mono-(2-ethylhexyl)phthalate | NA | chemical toxicant | NA | 2.60e-01 | 2.0e-02 | ACACB,APOBEC1,BCL2,DDIT4,HK2,IRS2,NAMPT,NFATC1,PDK4,PPARD,PPARG,ROCK2,TCF7L2,WDR43 | NA |
| CHUK | 5.30e-01 | kinase | NA | 2.60e-01 | 0.0e+00 | BCL2L1,CCL4,CCND1,CDKN1A,CEBPD,CX3CL1,CXCL10,GBP2,GBP4,HK2,IL1RN,Mt1,MYC,NFKB2,NFKBIA,OVOL1,RELB,RGS16,SGK1,ZNF395 | 279 (12) |
| BDNF | 1.90e-01 | growth factor | NA | 2.60e-01 | 0.0e+00 | APEX1,ATAT1,BCL2,BCL2L1,BHLHE40,CDKN1A,FSCN1,FTL,GLUL,GRIA2,IFRD1,INHBB,JUN,KLF4,LEP,LIMK1,P4HA1,PENK,RAB3A,S100A10,SBK1,SNAP25,TFRC,THBS1,TIPARP,TPH1,TRPC3 | 325 (20) |
| palbociclib | NA | chemical drug | NA | 2.60e-01 | 0.0e+00 | CCND1,CD83,CDKN1A,CLSPN,CXCL10,GADD45A,GBP4,IRS2,JUN,PER1,ZFP36 | 488 (26) |
| CDK6 | 2.00e-01 | kinase | NA | 2.60e-01 | 0.0e+00 | AGT,BIRC3,CDKN2C,FGF11,FOXO3,GADD45A,ITGA11,JUN,MGST2,MTHFR,NFKBIZ,PIK3CB,SERPINE1,TAP1,TEAD1 | 403 (21) |
| TET2 | 5.20e-01 | enzyme | NA | 2.60e-01 | 0.0e+00 | APOBEC1,ASPA,BHLHE40,FBXO15,FGL2,JAML,MAFF,Nepn,PXDC1,RND3,SLC16A12,SLC4A11,TRIOBP,XYLT1,ZBTB16 | NA |
| SIRT1 | 3.90e-01 | transcription regulator | NA | 2.60e-01 | 0.0e+00 | AGT,APLN,BCL2,BCL2L1,BCLAF1,BIRC3,BNIP3,CA12,CCND1,CD83,CDKN1A,CDKN2C,CFLAR,CORO1A,CYP2B6,DBP,DHX58,EDEM1,EIF2S2,EPAS1,FBXO39,FGF10,FGFR3,FLT3LG,FOXO1,FOXO3,GADD45A,HK2,Ifi47,Igtp,Irgm1,LEP,LGALS3,MTHFD1L,MYC,NDUFA5,NEURL1,NR1D1,NT5E,OAS2,Oasl2,PDK4,PER1,Pmaip1,PML,RELB,RGS16,SERPINE1,SLC27A6,SREBF1,SSBP3,TAP1,TGM2,UBA7 | 380 (21) |
| SPHK1 | 1.12e+00 | kinase | NA | 2.60e-01 | 0.0e+00 | BCL2L1,BIRC3,CCND1,CDKN1A,JUN,SERPINE1,SPHK1,TRAF1 | 345 (22) |
| calphostin C | NA | chemical drug | NA | 2.60e-01 | 0.0e+00 | AGT,AXIN2,BCL2,BCL2L1,CCND1,CDKN1A,ECE1,MYC,PPARG,STAR | 288 (19) |
| hydroxyurea | NA | chemical drug | NA | 2.60e-01 | 2.0e-02 | CCND1,CDKN1A,CSF3,GADD45A,GMNN,KLF4,MYC,PDE4A,TRAF1,WEE1 | NA |
| RUNX1-RUNX1T1 | NA | fusion gene/product | NA | 2.50e-01 | 0.0e+00 | ASPA,CDKN1A,ETV6,FOXO1,GNA15,IL6R,Nepn,PXDC1,RBM28,RND3,SCN1B,SLC16A12,XYLT1,ZBTB16 | 138 (7) |
| CEBPD | 8.40e-01 | transcription regulator | NA | 2.50e-01 | 0.0e+00 | ADRB3,AGT,Akr1c14,ATF4,CCND1,CDKN1A,CEBPD,CSF3R,HK2,IKBKE,LEP,MITF,MYC,PPARG | 375 (20) |
| TCF7L2 | -7.90e-01 | transcription regulator | NA | 2.50e-01 | 0.0e+00 | ABHD17B,ASPA,AXIN2,CCND1,CDKN1A,CREB3L2,CSF3,CSF3R,EFNB1,EN1,EPAS1,EPS15,EVI2A,FGFR2,GLUL,IDH1,IRS1,IRS2,JUN,LBH,MAP7,MET,MOSPD2,MYC,NPAT,PICALM,PPARD,PPARG,PTPN11,RALGDS,RASGEF1B,SGK1,SMAD7,SMURF1,STX2,TBC1D14,TCF7L2,TPPP | 427 (23) |
| HJURP | -3.30e-01 | other | NA | 2.50e-01 | 0.0e+00 | CCND1,CDKN1A,MYC,WEE1 | 342 (13) |
| raloxifene | NA | chemical drug | NA | 2.50e-01 | 0.0e+00 | BCL2,CCND1,CDKN1A,DDIT4,FMO5,IGFBP4,INHBB,IRF6,JUN,KLF6,MYBL1,NDRG1,PLK2,ROCK2,SERPINE1,SMAD7,TFRC | 452 (24) |
| caspase | NA | group | NA | 2.50e-01 | 1.0e-02 | BCL2,CCND1,CDKN1A,GLUL,THBS1 | NA |
| noscapine | NA | chemical drug | NA | 2.40e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CFLAR,TRAF1 | 348 (15) |
| SCAP | -2.80e-01 | other | NA | 2.40e-01 | 0.0e+00 | AACS,ACACB,ACLY,CYP2B6,FDPS,GPAM,LGALS3,MTHFD2,SLC7A1,SQLE,SREBF1 | 280 (9) |
| CD24 | NA | other | NA | 2.40e-01 | 0.0e+00 | BCLAF1,CDKN1A,HOMER3,HSPB8,JUN,OGG1,RELB,SPHK1,THBS1,TP53INP1,TRIM2,VDR | 351 (15) |
| ABCA1 | -5.40e-01 | transporter | NA | 2.40e-01 | 4.0e-02 | ABCA5,CSF3,LEP,NAMPT,PPARG,SREBF1 | NA |
| OSM | 5.60e-01 | cytokine | NA | 2.40e-01 | 0.0e+00 | ADAMTS1,ALOX12,ARL4A,BCL2,BHLHE40,CCL24,CCND1,CDKN1A,CEBPD,CHD1,CISH,CRP,CRY1,CSF2RB,CSF3,CXCL10,FAM171A1,FGF2,FMO5,GADD45G,GBP2,GLUL,HK2,HSD11B1,HSD11B2,IL1R2,IL6R,IRF1,IRS1,ITGAL,JAK3,JUN,KCNG1,MPZL2,MRC1,MYC,NAMPT,NUAK1,PGF,PPARG,PTPN11,RASD1,RORA,SERPINE1,SLC16A1,SLC7A8,TAP1,TLR2,TPO,TYRO3,VDR,VIP,WNT5A,ZFP36,ZNF467 | 417 (21) |
| CDKN1A | 2.30e+00 | kinase | NA | 2.40e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CDKN1A,CSF3,DTL,EDNRA,EGLN3,FANCG,FGF2,GADD45A,IRF6,LGALS3,LIMA1,MBNL2,MET,MYC,NFKBIA,NRP1,NRP2,P4HA1,PELO,PLK2,Pmaip1,POLD1,PRF1,PROM1,SERPINE1,THBS1,VGLL4,XRCC6 | 368 (19) |
| dactolisib | NA | chemical drug | NA | 2.40e-01 | 3.0e-02 | ALDH9A1,BCL2,CDKN1A,DDIT4,EGLN3,MYC,P4HA1 | NA |
| GATA3 | -2.40e-01 | transcription regulator | NA | 2.40e-01 | 0.0e+00 | BCL2,BCL2L1,CCL4,CCND1,CDKN1A,CDKN2C,ELOVL4,FSCN1,GLUL,IL2RB,IRF6,ITGAL,KLF4,LOX,MYC,MYO10,NFIL3,OVOL1,PPARD,PPARG,TBX3,TGM2,ZBTB16 | 383 (20) |
| 5-fluorouracil | NA | chemical drug | NA | 2.40e-01 | 0.0e+00 | ATF4,BCL2,BCL2L1,BNIP3,BTG2,CCND1,CDKN1A,CFLAR,EIF2S2,EIF4A1,FDPS,FGFR2,FOXO1,GADD45A,JUN,MYC,NNT,NUCKS1,PIK3CG,PLK2,SAT1,SPHK1,THBS1,TRAF4,TSC22D1,UPP1,USP27X,VDR | 420 (19) |
| nicotine | NA | chemical drug | NA | 2.40e-01 | 0.0e+00 | BCL2,CCL4,CCND1,CDKN1A,CFLAR,CYP2B6,FGF2,HSD11B2,IKBKE,KDR,LEP,LGALS3,MRC1,NR3C2,OGG1,PENK,PPARD,SERPINE1,SREBF1,WNT5A,ZFP36 | 372 (19) |
| miR-145-5p (and other miRNAs w/seed UCCAGUU) | NA | mature microRNA | NA | 2.30e-01 | 1.0e-02 | FSCN1,IRS1,KLF4,MITF,MYC,PROM1,RAB27A,SERPINE1,STAR | 424 (15) |
| Vhl | NA | complex | NA | 2.20e-01 | 0.0e+00 | BIRC3,CCND1,CFLAR,INHBB | 167 (9) |
| FOXF1 | -4.80e-01 | transcription regulator | NA | 2.20e-01 | 0.0e+00 | CCND1,CDKN1A,ERRFI1,FGF2,KDR,WNT5A | NA |
| PRKN | NA | enzyme | NA | 2.20e-01 | 0.0e+00 | AXIN2,CCND1,CDKN1A,CSF3,IGFBP4,KDR,MYC,PLK2,PRDX6,SERPINE1,TCF7L2,TOMM20 | 407 (21) |
| miR-3648 (miRNAs w/seed GCCGCGG) | NA | mature microRNA | NA | 2.20e-01 | 1.0e-02 | CCND1,FRAT2,JUN,MST1R,MYC,NDRG1,NRARP,OTUD1,PER3,TBC1D14,ZBED3 | NA |
| WNT1 | NA | cytokine | NA | 2.20e-01 | 2.0e-02 | AXIN2,CCND1,CDKN1A,EFNB1,GADD45G,JUN,LBH,LMX1A,MYC,PPARG,SERPINE1,STAT5A | NA |
| tretinoin | NA | chemical drug | NA | 2.20e-01 | 0.0e+00 | ACACB,ADCYAP1R1,AGT,AGTR1,ALDH1A3,ALDH9A1,APEX1,APLN,APLNR,ATF4,BACH2,BCL2,BCL2L1,BHLHE40,BIRC3,BMPR2,BNIP3,BTG1,BTG2,CALML3,CBS/LOC102724560,CCL24,CCL4,CCND1,CD244,CD300C,CD38,CDKN1A,CDKN2C,CHL1,Clec2d (includes others),CSF3,CSF3R,CSRNP1,CX3CR1,CXCL10,CYP2B6,CYP4F22,DACT2,DHX58,DTL,DUSP9,ECE1,EFNB1,EIF4A1,ELOVL4,EN1,ERRFI1,ETV6,FGF2,FGFR4,FGR,FMN2,FOXO1,FOXO3,FRAT2,FZD8,GAL,GATA6,GBP4,GMNN,GRB7,HAS2,HOGA1,HOXD3,HSD11B1,HUS1,IFI44L,IGFBP4,IL6R,IMPDH2,IRF1,IRS1,ITGA1,ITGAL,ITGB7,JAML,JUN,KCTD11,KDR,KLB,KLF4,LIMK1,LRAT,LTB4R,MAP3K5,MAP7,MAPK6,MEI1,MEIS2,MERTK,MST1,Mt1,MTHFD2,MYC,NDRG1,NFATC1,NFKB2,NOG,NR3C1,NRP1,OAS2,PCYT1A,PENK,PIK3C2A,PIK3CG,PLEK,PLK2,PML,PPARD,PPARG,PROM1,PTPN11,RXRB,S100A10,SAMHD1,SEMA6B,SERPINE1,SIRPA,SLC16A1,SLC16A13,SLC6A6,SMAD7,SOX17,SREBF1,STAR,TAP1,TAX1BP1,TCF3,TFRC,TGM2,THBS1,TLR2,TOB1,TRPC3,TYK2,UBA7,VDR,VIP,VMP1,WNT5A,XRCC6,ZBTB16,ZNF566 | 455 (19) |
| IKBKG | 9.00e-02 | kinase | NA | 2.20e-01 | 0.0e+00 | BIRC3,CEBPD,CFLAR,CX3CL1,CXCL10,EPAS1,GBP2,HK2,IKBKE,IL1RN,Mt1,NFKB2,NFKBIA,PPARG,RELB,RGS16,SGK1,TPO | 336 (13) |
| POLDIP2 | NA | other | NA | 2.20e-01 | 0.0e+00 | HK2,KLF4,LGALS3,POLD1,SREBF1 | NA |
| decursin | NA | chemical - endogenous non-mammalian | NA | 2.20e-01 | 1.0e-02 | CCND1,CDKN1A,KDR,MYC | 429 (23) |
| acetyl-L-carnitine | NA | chemical - endogenous mammalian | NA | 2.20e-01 | 1.0e-02 | CDKN1A,GABPB1,GADD45A,PPARG | 243 (7) |
| WR 1065 | NA | chemical drug | NA | 2.20e-01 | 3.0e-02 | CDKN1A,GADD45A,KDR,MYC | NA |
| CDK2 | -3.00e-02 | kinase | NA | 2.20e-01 | 5.0e-02 | CDKN1A,MYC,PCYT1A,RAB27A,SNAP25 | NA |
| ILF3 | 0.00e+00 | transcription regulator | NA | 2.20e-01 | 5.0e-02 | CXCL10,FDPS,FKBP5,IL1RN,LGALS3,PPARG,SLC3A2,TRAF1 | NA |
| mir-155 | NA | microRNA | NA | 2.10e-01 | 0.0e+00 | AGTR1,BCL2,CCND1,CDKN1A,CSF3,CXCL10,FADD,FOXO3,GCSAM,HK2,IKBKE,JARID2,MRC1,PPARG,RORA,SERPINE1,TP53INP1,WEE1 | 413 (21) |
| SQSTM1 | 2.40e-01 | transcription regulator | NA | 2.10e-01 | 0.0e+00 | CXCL10,CYP2B6,EGLN3,FGL2,IRF1,JUN,LEP,NFKBIA,PLK2,TSC22D1 | 305 (17) |
| oleic acid | NA | chemical - endogenous mammalian | NA | 2.10e-01 | 0.0e+00 | ACACB,ATF4,CD38,CFLAR,CX3CL1,GADD45A,GPAM,HK2,Mt1,NFKBIA,PDK4,PLIN4,PPARG,SERPINE1,SPHK1,SREBF1,TLR2 | 425 (24) |
| carboplatin | NA | chemical drug | NA | 2.10e-01 | 0.0e+00 | A3GALT2,HAS2,LGALS3,MRC1,MYC,NT5E,RBM3,UPP1 | NA |
| IKZF1 | NA | transcription regulator | NA | 2.10e-01 | 0.0e+00 | ADAM19,BCL2L1,C1QTNF1,CCL4,CD38,CD8A,CDKN1A,CISH,CSF3,DTX3L,EXOC3L1,FGFR4,FOXO1,FOXO3,HK2,IL2RB,KLF4,LHFPL2,LILRB3,MYC,NFKB2,NFKBIZ,NR3C1,NRARP,OTUD1,RAPGEF4,RASSF4,SLC19A1,SPSB1,ST3GAL6 | 434 (20) |
| SATB1 | -3.10e-01 | transcription regulator | NA | 2.10e-01 | 1.0e-02 | BCL2,CCND1,CD8A,CDKN1A,CSF3R,EPAS1,EVI2A,GPT2,HVCN1,IL1R2,LPIN2,RELB,SGK1,SUN2,TMEM241 | 389 (17) |
| PLX5622 | NA | chemical drug | NA | 2.10e-01 | 1.0e-02 | ATF4,CCL24,CCL4,CDKN1A,CNTNAP1,CSF2RB,CSF3,CX3CL1,CX3CR1,CXCL10,CYTH4,GRIA2,HAP1,IL1RN,IL2RB,IL6R,NAMPT,RAB3A,STX1A,STX2,TLR2 | NA |
| STAT6 | -3.80e-01 | transcription regulator | NA | 2.00e-01 | 0.0e+00 | ADAM19,ANKRD55,BCL2,BCL2L1,CCL24,CD38,CDKN1A,CIDEC,CISH,CXCL10,DDHD1,DHX58,FKBP5,FSCN1,GADD45G,GBP2,GBP5,GCSAM,GNA15,H2-T22,IFI44L,Igtp,IL1RN,IRF1,Irgm1,IRS2,ITGB7,LPIN2,MAP3K5,MOV10,MRC1,NFATC1,NFIL3,NFKBIA,PCYOX1L,PDK4,PSTPIP1,RASSF4,S100A10,SERPINE1,SLC25A25,SPHK1,STAT5A,TMTC1,TP53I11,TRPV2,ZFP36 | 399 (14) |
| DGAT1 | 1.60e-01 | enzyme | NA | 2.00e-01 | 0.0e+00 | LEP,PDK4,PPARD,PPARG | 400 (23) |
| PCLAF | NA | other | NA | 2.00e-01 | 1.0e-02 | CDKN1A,CDKN2C,GADD45G,KLF4,MYC | NA |
| CEBPA | -5.30e-01 | transcription regulator | NA | 2.00e-01 | 0.0e+00 | ACLY,ADH1C,ADRB3,AGT,APLN,APLNR,ATF4,BCL2,BTG1,BTG2,CCL4,CCND1,CDKN1A,CEBPD,CSF3,CSF3R,CYP2B6,FOXO1,FOXO3,GABPB1,GADD45A,GAL,GATA6,HAS2,HPGD,HSD11B1,IGFBP4,IL1RN,IL6R,IRF6,IRS1,IRS2,ITGAL,JUN,KLF4,LEP,MYC,NFATC1,NFIL3,NRP1,OAS2,OVOL1,PLXND1,PPARD,PPARG,RORA,SERPINE1,SREBF1,STAR,THBS1,TRAF4,TRIB1,VDR | 423 (21) |
| CISH | -9.70e-01 | other | NA | 1.90e-01 | 0.0e+00 | BACH2,BCL2L1,CCL4,CISH,CSF3R,CXCL10,HDC,IFRD1,MYC,PRF1,SPHK1 | 378 (19) |
| IGFBP5 | -7.00e-02 | other | NA | 1.90e-01 | 0.0e+00 | BCL2,BCL2L1,BHLHE40,CCND1,IRS1,SERPINE1 | 388 (25) |
| VTN | 2.00e-02 | other | NA | 1.90e-01 | 0.0e+00 | BCL2,BCL2L1,BHLHE40,CDKN1A,IRS1,S100A10,SERPINE1 | 398 (20) |
| mir-21 | NA | microRNA | NA | 1.90e-01 | 0.0e+00 | BCL2,BMPR2,BTG2,CD180,CDKN1A,CSF3R,CXCL10,DBP,DHX58,F830016B08Rik,FGL2,FLT3LG,GBP2,GBP5,Ifi47,IL6R,IRF1,Irgm1,MYC,NUCKS1,OAS2,PER3,PILRB,RAB7B,SIRPA,SLC16A10,SMAD7,TAP1,TLR2,TRAF1,UBA7 | 364 (16) |
| Pkc(s) | NA | group | NA | 1.90e-01 | 0.0e+00 | APLN,BCL2,BCL2L1,CDKN1A,DBP,FGF2,GADD45A,HPGD,IRF6,IRS1,JUN,KLF6,MAFK,MAP3K5,NR1D1,OVOL1,PER1,PPARG,SERPINE1,SLC6A9,STAR,VDR | 368 (22) |
| TGM2 | 9.10e-01 | enzyme | NA | 1.90e-01 | 0.0e+00 | BIRC3,BNIP3,BTG2,CCL24,CCND1,CD300C,CFLAR,CSF3,CSRNP1,CX3CR1,CXCL10,JAML,MERTK,MYC,OAS2,SAMHD1,SEMA6B,SIRPA,SLC16A1,SLC16A13,TAP1,THBS1,UBA7,VIP,ZNF566 | 381 (20) |
| PRDM16 | -5.20e-01 | transcription regulator | NA | 1.90e-01 | 0.0e+00 | AGT,CDKN1A,CXCL10,GADD45G,GBP4,OAS2,SERPINE1 | 334 (18) |
| FBXW7 | 0.00e+00 | enzyme | NA | 1.80e-01 | 0.0e+00 | BCL2,CARD11,CEBPD,CIDEC,GPAM,IDH1,JUN,MCAT,MTHFD2,MYC,NFKB2,NFKBIA,NR3C1,PPARG,SERPINE1,SQLE,SREBF1 | 381 (19) |
| RELB | -1.13e+00 | transcription regulator | NA | 1.70e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,Madcam1,MYC,NFKB2,NFKBIA,RELB | 287 (17) |
| PPARG | -6.80e-01 | ligand-dependent nuclear receptor | NA | 1.70e-01 | 0.0e+00 | ACLY,ADRB3,AGT,AGTR1,ALDH9A1,ALOX12,BCL2,BCL2L1,CCND1,CDKN1A,CDKN2C,CIDEC,CSF3,EGLN3,EPAS1,FDPS,GPAM,H6PD,HCAR1,HK2,HR,IDH1,IRS1,IRS2,JUN,KLB,KLF4,KLF6,LEP,MRC1,NDRG1,NDUFA5,NR1D1,PDE3B,PDK4,PLIN4,PPARD,PPARG,SAT1,SERPINE1,SGK1,SREBF1,STAR,TRAF6,TRERF1,UCK1,VDR,XYLT1 | 423 (22) |
| FTO | -1.00e-02 | enzyme | NA | 1.70e-01 | 3.0e-02 | CCND1,JUN,LEP,MYC,NOG | NA |
| salicylic acid | NA | chemical drug | NA | 1.60e-01 | 0.0e+00 | ADRB3,BCL2L1,CCL4,CFLAR,CSF3,CXCL10,EIF3A,FKBP5 | 410 (23) |
| PTPN6 | -3.50e-01 | phosphatase | NA | 1.60e-01 | 1.0e-02 | BCL2,BCL2L1,CCND1,CXCL10,ENY2,IRF1,MYC,TCF7L2 | NA |
| 2,4,5,2’,4’,5’-hexachlorobiphenyl | NA | chemical toxicant | NA | 1.60e-01 | 0.0e+00 | BCL2,CYP2B6,FMO5,GADD45A,MBNL2,MYC,PICALM,PIK3C2A,RBM47,SMAD7,SREBF1,WEE1 | 245 (7) |
| acyclic retinoid | NA | chemical drug | NA | 1.60e-01 | 1.0e-02 | CCND1,CDKN1A,KDR,MYC | 356 (22) |
| CCN1 | NA | other | NA | 1.60e-01 | 0.0e+00 | BCL2L1,CCL4,CCND1,CDKN1A,CXCL10,FZD8,JUN,KDR,MYC,SERPINE1,WNT5A | 349 (22) |
| ZBTB20 | 4.40e-01 | transcription regulator | NA | 1.60e-01 | 0.0e+00 | CISH,CYP2B6,HSPB8,IRS1,LEP,NFKBIA,NR3C1,PDK4,TFRC | 268 (12) |
| SOD2 | 7.00e-02 | enzyme | NA | 1.60e-01 | 0.0e+00 | BCL2,BCL2L1,CDKN1A,IQCE,MARK1,MYC,PLAGL1,PTPRO,SERPINE1,SLIT1,TMC1,TRIM14,TULP2 | 380 (22) |
| TLR4 | -3.40e-01 | transmembrane receptor | NA | 1.50e-01 | 0.0e+00 | BCL2,BCL2L1,CCL4,CD38,CEBPD,CFLAR,CISH,CSF3,CXCL10,FGL2,FLT3LG,GADD45G,GBP2,GPR34,HDC,HK2,Ifi47,Igtp,IL2RB,IRF1,Irgm1,LYVE1,MERTK,MET,MYC,NFKB2,NFKBIA,NFKBIZ,PLAGL1,PLEK,PLK2,PML,PPARG,RELB,RGS16,SPHK1,SREBF1,STAT5A,TFRC,TLR2,TRAF1,TRAF6,TSC22D1 | 400 (19) |
| ACACA | 2.90e-01 | enzyme | NA | 1.50e-01 | 0.0e+00 | ACACB,ACLY,GPAM,PPARG,SREBF1 | 225 (12) |
| FGFR4 | -9.20e-01 | kinase | NA | 1.50e-01 | 0.0e+00 | ACACB,ACLY,BCL2L1,CCND1,CDKN1A,KDR,SERPINE1,SREBF1 | 348 (20) |
| nimbolide | NA | chemical - endogenous non-mammalian | NA | 1.50e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1 | 268 (12) |
| EIF2S1 | 4.20e-01 | translation regulator | NA | 1.50e-01 | 0.0e+00 | ATF4,CCND1,CFLAR,DENND2D,GADD45A,IFRD1,PLIN4,SLC6A9,SYBU | 246 (7) |
| TAS1R3 | 1.60e-01 | G-protein coupled receptor | NA | 1.50e-01 | 0.0e+00 | DDIT4,PPARG,SLC16A1,SLC3A2 | NA |
| FGFR3 | 7.20e-01 | kinase | NA | 1.50e-01 | 1.0e-02 | BCL2L1,CCL4,CCND1,CDKN1A,HK2,NOG | 331 (19) |
| MST1R | -8.00e-01 | kinase | NA | 1.50e-01 | 1.0e-02 | CCL4,CCND1,JUN,MST1R,MYC | 329 (18) |
| PCDH11Y | NA | other | NA | 1.50e-01 | 1.0e-02 | AXIN2,CCND1,JUN,MYC | NA |
| GADD45A | -8.60e-01 | other | NA | 1.50e-01 | 1.0e-02 | BCL2,BCL2L1,CDKN1A,JUN | NA |
| Gli | NA | group | NA | 1.50e-01 | 2.0e-02 | BCL2,CCND1,IL6R,MYC | NA |
| GHR | 5.00e-02 | transmembrane receptor | NA | 1.50e-01 | 2.0e-02 | CCND1,CDKN1A,CISH,IGFBP4,LEP,MYC,PPARG | NA |
| CDKN2B | 1.00e-01 | transcription regulator | NA | 1.50e-01 | 4.0e-02 | BCL2,GLUL,GPT2,SERPINE1 | NA |
| 7(R)-maresin 1 | NA | chemical - endogenous mammalian | NA | 1.50e-01 | 4.0e-02 | ALOX12,CCL4,CSF3,JUN | NA |
| GSK3A | 1.70e-01 | kinase | NA | 1.50e-01 | 1.0e-02 | CFLAR,IRS1,KDR,SERPINE1 | NA |
| LGR4 | 4.40e-01 | transmembrane receptor | NA | 1.50e-01 | 0.0e+00 | AXIN2,CXCL10,GLUL,Gulo,MYC,NR3C2,RDH16,SLC16A10,STAR,WNT5A | 419 (18) |
| RAC1 | -1.00e-02 | enzyme | NA | 1.40e-01 | 0.0e+00 | AGT,BCL2L1,CCND1,CRP,CYLD,FGF2,FOXO1,HSD11B2,IL6R,JUN,KLF4,MYC,PROM1,WNT5A | 406 (20) |
| miR-182-5p (and other miRNAs w/seed UUGGCAA) | NA | mature microRNA | NA | 1.40e-01 | 0.0e+00 | BCL2,CARD11,FOXO1,FOXO3,GADD45G,IFI44L,MITF,OAS2,PGF | NA |
| HIPK2 | 1.30e-01 | kinase | NA | 1.40e-01 | 0.0e+00 | ANK1,BCL2,BCL2L1,CDKN1A,CITED1,GATA6,ITGA1,LGALS3,TMEM26,TMEM45B | 401 (21) |
| CRTC2 | 6.00e-02 | other | NA | 1.30e-01 | 0.0e+00 | BACH2,BCL2,CCND1,MYC,SREBF1,TCF3 | 426 (24) |
| clenbuterol | NA | chemical drug | NA | 1.30e-01 | 1.0e-02 | BCL2L1,IL1RN,SLC16A1,VDR | NA |
| BTRC | -3.00e-01 | enzyme | NA | 1.30e-01 | 0.0e+00 | AXIN2,BCL2L1,CCND1,CDKN1A,CHD1,GLUL,TRAF1 | 382 (20) |
| UCP2 | 1.10e-01 | transporter | NA | 1.30e-01 | 0.0e+00 | BCL2,EPAS1,HDC,HK2,LTB4R,MYC | 356 (19) |
| NVP-TAE684 | NA | chemical drug | NA | 1.30e-01 | 1.0e-02 | BCL2,CCND1,ESRP2,MITF,MYC,SERPINE1 | 330 (19) |
| E. coli lipopolysaccharide | NA | chemical - endogenous non-mammalian | NA | 1.30e-01 | 0.0e+00 | ATG7,BCL2,BCL2L1,CCL4,CD83,CEBPD,CXCL10,FDPS,IL1R2 | 350 (16) |
| ITGAV | 3.40e-01 | transmembrane receptor | NA | 1.20e-01 | 0.0e+00 | BCL2,BCL2L1,CCL4,CDKN1A,CXCL10,GBP2,HAS2,ITGA1,SERPINE1 | 381 (21) |
| 2-deoxyglucose | NA | chemical drug | NA | 1.20e-01 | 0.0e+00 | ATF4,BCL2,BCL2L1,CCND1,CD244,CDKN1A,CFLAR,DDIT4,HK2,JUN,LEP,MYC,PPARG,PRF1 | 406 (22) |
| DCN | 1.20e-01 | other | NA | 1.20e-01 | 0.0e+00 | CDKN1A,CXCL10,FGF2,IRS1,MET,SERPINE1,TFEB,THBS1 | 390 (21) |
| RXRA | 7.00e-02 | ligand-dependent nuclear receptor | NA | 1.20e-01 | 0.0e+00 | ACACB,ADH1C,ATF4,CCND1,CD38,CDKN1A,CEBPD,CXCL10,CYP2B6,FLRT3,FTL,GADD45G,HAS2,HSD11B2,MYO1E,NR1D1,PPARD,PPARG,PPP1R15B,RORA,RRP12,SAT1,SREBF1,STAR,TOB1,VDR,VMP1,WEE1,ZFP37,ZNF423 | 330 (20) |
| SP1 | 8.00e-02 | transcription regulator | NA | 1.20e-01 | 0.0e+00 | ADAMTS1,ADRA1D,AGTR1,ALOX12,ANK1,BCL2,CBS/LOC102724560,CCND1,CDKN1A,CDKN2C,CEBPD,CIRBP,COL7A1,CXCL10,CYP2B6,FGF10,FGF2,FGFR4,GRIA2,HAS2,HDC,HK2,HSD11B2,IGFBP4,IL2RB,IRF1,JUN,KDR,KLF4,KLF6,LTB4R,MET,MRC1,MST1R,Mt1,MYBL1,MYC,NDRG1,NFKBIA,OGG1,PCYT1A,PENK,PIGM,POLD1,PPARD,PROM1,RANBP1,RNLS,SERPINE1,SGK1,SLC19A1,SLC7A1,SMAD7,SNAP25,SREBF1,STAR,STX1A,TEAD1,TLR2,TRIB1,VDR | 439 (25) |
| STAT | NA | group | NA | 1.10e-01 | 0.0e+00 | AGT,BCL2L1,CDKN1A,CEBPD,CISH,CRP,IRF1,SMAD7,VIP | 369 (12) |
| SERPINF1 | 2.80e-01 | other | NA | 1.10e-01 | 0.0e+00 | AXIN2,BCL2,BCL2L1,CCND1,MYC,NFKBIA,PPARG,THBS1 | 379 (19) |
| P2RY2 | 2.10e-01 | G-protein coupled receptor | NA | 1.10e-01 | 0.0e+00 | BCL2L1,CCND1,CDKN1A,FOXO1,HAS2,JUN,OGG1,SERPINE1 | 371 (21) |
| CFTR | -2.00e-02 | ion channel | NA | 1.10e-01 | 5.0e-02 | CYP2B6,EPHX2,FDPS,HPGD,NFKBIA,NFKBIZ,SLC7A8,SQLE | NA |
| CpG ODN 2006 | NA | chemical reagent | NA | 1.10e-01 | 1.0e-02 | ANKRD33B,BCL2L1,BIRC3,CD22,CXCL10,CXCL11,GBP4,GBP5,HDAC5,IFI44L,IL2RB,IRS2,LGALS3,NFKB2,NFKBIZ,PDE4D,PSMD8,SEMA4B,TFRC,TRAF1,XRCC6 | 336 (13) |
| dextran sulfate | NA | chemical drug | NA | 1.10e-01 | 0.0e+00 | ADAMTS1,AGT,AGTR1,BCL2,BLM,CARD11,CCL4,CCND1,CD83,CDKN1A,CSF3,CX3CR1,CXCL10,FANCA,FGFR3,IL22RA2,KCTD11,Madcam1,MRC1,MYC,NRP1,PGF,POLD1,SERPINE1,SPHK1,TGM2,THBS1,VDR,WNT5A | 353 (16) |
| fisetin | NA | chemical drug | NA | 1.10e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,MYC,NFATC1,NFKBIA,TRAF1 | 308 (16) |
| ROR2 | 1.90e-01 | kinase | NA | 1.10e-01 | 0.0e+00 | AXIN2,BCL2,CCND1,CDKN1A,CHEK2,PIP5K1B,PPARG,ROCK2,SRFBP1,TEAD2,TRAF4,WEE1,WNT5A | 426 (24) |
| miR-27a-3p (and other miRNAs w/seed UCACAGU) | NA | mature microRNA | NA | 1.00e-01 | 0.0e+00 | ACACB,ACLY,EDNRA,FADD,FOXO1,JUN,Pmaip1,PPARG,SREBF1,WEE1 | NA |
| tacrolimus | NA | chemical drug | NA | 1.00e-01 | 0.0e+00 | ADAM19,BCL2,BCL2L1,CCL4,CCND1,CISH,CXCL10,ELL2,FKBP5,IGFBP4,IL1R2,IL2RB,ITGB7,JUN,LBH,MYC,MYO1E,NFATC1,NFKBIA,NR3C1,NRP1,NT5E,PDE3B,PENK,PRF1,PROM1,RRP12,SAMHD1,SMAD7,STAT5A,TLE3,TMEFF1 | 414 (22) |
| KDM4A | -1.00e-01 | transcription regulator | NA | 1.00e-01 | 2.0e-02 | CCND1,CDKN1A,CXCL10,CXCL11 | NA |
| NCOA1 | -5.00e-02 | transcription regulator | NA | 8.00e-02 | 0.0e+00 | BTG2,CCND1,CDKN1A,CYP2B6,DBP,FGF2,FGFR2,FRAT2,HAS2,HSD11B1,IL1RN,KDR,LEP,MYC,NFKBIA,NFKBIZ,PPARD,PPARG,SERPINE1,SREBF1 | 375 (19) |
| zerumbone | NA | chemical - endogenous non-mammalian | NA | 8.00e-02 | 0.0e+00 | ATF4,BCL2,BCL2L1,BIRC3,CCND1,CFLAR,MYC,TRAF1 | 291 (15) |
| diethylstilbestrol | NA | chemical drug | NA | 8.00e-02 | 0.0e+00 | ADCYAP1R1,ADGRD1,ADH1C,ALDH1A3,CCND1,CD83,CDKN1A,DLG3,ENDOU,FDPS,FMO1,GADD45A,GAL,GATA6,HDC,IL1R2,INHBB,IRS1,KDR,KLF4,LEP,NR3C1,PROM1,STAR,STAT5A,TDRD1,Tlr12,VDR,VIP,WNT5A | 452 (24) |
| PLAT | 4.00e-02 | peptidase | NA | 7.00e-02 | 2.0e-02 | CCND1,CXCL10,JUN,MYC,SERPINE1 | NA |
| SCD | 2.00e-01 | enzyme | NA | 7.00e-02 | 0.0e+00 | ACACB,ADH1C,ADRB3,ALDH1A3,BCL2,CXCL10,DAGLA,GADD45A,GPAM,HR,IL1RN,JUN,KLF4,LEP,LPIN2,LRAT,MC5R,PDK4,PPARD,PPARG,RDH16,SQLE,SREBF1,THBS1,TMEM26,VDR | 396 (21) |
| PRMT1 | 9.00e-02 | enzyme | NA | 7.00e-02 | 0.0e+00 | ALOX12,AXIN2,BCL2,CCND1,CFLAR,FTL,KLF4,MRC1,PDK4,PPARG,SERPINE1,SMAD7 | 408 (22) |
| GLI2 | 2.00e-01 | transcription regulator | NA | 7.00e-02 | 0.0e+00 | BCL2,BCL2L1,CCL24,CCL4,CCND1,CDKN1A,CSF3,CXCL10,HK2,HSD11B2,IL6R,IRF6,MITF,MYC,OVOL1,VDR,WNT5A | 434 (25) |
| SOX4 | NA | transcription regulator | NA | 7.00e-02 | 0.0e+00 | BCAR3,BCL2,BMPR2,EVI2A,GRB7,GRIA2,IGFBP4,MAP7,MGST2,Mt1,NRP1,NUAK1,PLXNA1,PLXNA2,PLXND1,TCF3,TEAD1,TPH1 | NA |
| PRKCE | -1.20e-01 | kinase | NA | 7.00e-02 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,CDON,CRP,CSF3,IL2RB,JUN,MYC,STAR | 369 (19) |
| HEY1 | 1.60e-01 | transcription regulator | NA | 7.00e-02 | 3.0e-02 | CDKN1A,GATA6,KDR,NFATC1 | NA |
| PI3K (family) | NA | group | NA | 7.00e-02 | 0.0e+00 | ATG7,BCL2,BIRC3,CFLAR,CXCL10,CXCL11,DDIT4,EGLN3,FDPS,FOXO1,FOXO3,LEP,MYC,SERPINE1,SKIL,SREBF1,TGM2,THBS1 | 424 (23) |
| USP2 | 5.70e-01 | peptidase | NA | 6.00e-02 | 0.0e+00 | CDKN1A,CFLAR,SERPINE1,SMAD7 | 238 (15) |
| CDX2 | NA | transcription regulator | NA | 6.00e-02 | 1.0e-02 | AXIN2,BCL2,CDKN1A,HOXC6,HOXD3,JUN,KLF4,LMX1A,MYC,NFKB2,SLC26A6,SLC7A8,SOX17,TCF7L2,TFEB | 444 (26) |
| aspirin | NA | chemical drug | NA | 5.00e-02 | 0.0e+00 | APLN,APLNR,BCL2,BCL2L1,CCL4,CCND1,CD38,CDKN1A,CRP,CSF3,CX3CL1,CXCL10,EDNRB,HPGD,ITGA1,KDR,PPARD,TFEB,THBS1,TRPC3 | 420 (17) |
| mir-29 | NA | microRNA | NA | 5.00e-02 | 1.0e-02 | BCL2,CCND1,COL7A1,FKBP5,ITGA11,KLF4,LEP,NR3C1,THBS1,TRAF4 | NA |
| CSF1 | -3.00e-01 | cytokine | NA | 5.00e-02 | 0.0e+00 | APOBEC1,BCL2,BCL2L1,BHLHE40,CCND1,CD83,CDKN1A,CX3CR1,CXCL10,CXCL11,DAGLA,DUSP9,FDPS,FHL2,GPR34,HK2,HPGD,IKBKE,IL2RB,IRF1,JUN,LYVE1,MERTK,MRC1,MYC,NFATC1,NFKB2,OAS2,PPARG,SLC7A5,SQLE,THBS1,TLR2,TRAF6,TRIM14 | 387 (18) |
| 25-hydroxycholesterol | NA | chemical reagent | NA | 4.00e-02 | 0.0e+00 | ACLY,ATF4,CCND1,FDPS,JUN,MAFF,MYC,NFKBIA,SREBF1 | 310 (20) |
| baicalein | NA | chemical drug | NA | 4.00e-02 | 1.0e-02 | BCL2,BCL2L1,CCND1,JUN,KDR,PRDX6 | NA |
| valproic acid | NA | chemical drug | NA | 4.00e-02 | 0.0e+00 | AACS,ALOX12,ATF4,BCL2,BCL2L1,CA12,CCND1,CD83,CDKN1A,CRHR2,CYP2B6,EDEM1,ETV6,FAM107A,FDPS,FSCN1,GLUL,GPAM,H6PD,HDAC5,JUN,LEP,LIMA1,LRAT,MAS1,MTHFR,NR3C1,OSBPL5,PPARG,PSMD8,RCL1,RDH16,SERPINE1,SGK1,SLC7A8,SMIM3,SQLE,SREBF1,STAR,TCF3,TCF7L2,TGM2,THBS1,TNK2,WNT5A | 510 (26) |
| sulindac sulfide | NA | chemical drug | NA | 4.00e-02 | 0.0e+00 | ATF4,BCL2L1,CCND1,CDKN1A,GADD45A,GADD45G,IFRD1,MTHFD2,PPARD,PPP2R2A,RANBP1,XRCC6 | 328 (16) |
| HNRNPK | 4.00e-01 | other | NA | 3.00e-02 | 0.0e+00 | AGT,CDKN1A,COL12A1,HUS1,IGSF10,MYC,PDLIM2,PPARG | 252 (12) |
| NfkB-RelA | NA | complex | NA | 3.00e-02 | 0.0e+00 | AGT,BCL2,BCL2L1,CXCL10,CXCL11,IRF1,MYC,NFKBIA,NR3C1 | NA |
| ERBB2 | -3.20e-01 | kinase | NA | 2.00e-02 | 0.0e+00 | ADAM19,ADRB3,APLNR,ATF4,AXIN2,BCL2,BCL2L1,BHLHE40,BIRC3,BNIP3,BTG2,CCL4,CCND1,CDC37L1,CDC42EP2,CDKN1A,CDKN2C,CDON,CIDEC,CNTD1,COL7A1,CX3CR1,CXCL10,EDNRB,ELK3,ELL2,EPHX2,EPS15,ETV6,FOXO1,FSCN1,GLUL,GPAM,H6PD,HAS2,HSPB8,IDH1,IGFBP4,IL6R,IRF6,JUN,KDR,KIFC3,KLF4,LGALS3,MITF,MRC1,MYBL1,MYC,MYO10,NDRG1,NFKB2,NFKBIA,NRP1,NT5E,NUCB2,ORC2,PDK4,PENK,PER1,POLD1,POLR2D,POLR3K,POMK,PPARG,PRIMA1,PROM1,PSMD8,PTPRB,RASA3,S1PR5,SERPINE1,SIRPA,SLC7A1,SLC7A5,SMAD7,SPAG1,SQLE,ST3GAL6,TAP1,TCEAL9,THBS1,TRAF1,TSC22D1,UCK1,VDR,WNT5A | 402 (18) |
| PTPN1 | 3.60e-01 | phosphatase | NA | 2.00e-02 | 0.0e+00 | ADRA1A,ADRA1D,CFLAR,EDEM1,IRS1,IRS2,LEP,MET,NFKBIA,PLAGL1,SMAD7,SREBF1,TMEM26 | 379 (21) |
| cytokine | NA | group | NA | 2.00e-02 | 0.0e+00 | BCL2,BCL2L1,CCND1,CISH,CRP,CX3CL1,FGF2,IRF1,JUN,LEP,MYC,SERPINE1,SGK1,STAT5A,TLR2,UPP1 | 280 (17) |
| INHBA | -2.30e-01 | growth factor | NA | 2.00e-02 | 0.0e+00 | ACVR1,BCL2,BCL2L1,CCND1,CDKN1A,EGLN3,FIGN,INHBB,IRF1,ITGA11,KLF4,LOX,PCSK5,PGM2L1,RGS16,SERPINE1,SMAD7,SOX17,STAR | 351 (19) |
| STAT5a/b | NA | group | NA | 2.00e-02 | 3.0e-02 | BCL2,BCL2L1,CCND1,CDKN1A,CDKN2C,CISH,EPHA4,IRF1,MYC,PRF1,TLR2 | NA |
| fenofibrate | NA | chemical drug | NA | 1.00e-02 | 1.0e-02 | ACACB,APEX1,CCND1,CRP,GADD45A,GLUL,GPAM,HOXC6,JUN,KDR,MITF,NR3C1,PDK4,POLD1,RORA,SERPINE1,SREBF1,STAR,STK36,TP53INP1 | NA |
| PRKCD | -4.40e-01 | kinase | NA | 0.00e+00 | 0.0e+00 | BCL2,BCL2L1,BIRC3,BNIP3,CCND1,CDKN1A,CX3CL1,CXCL10,IL1RN,JUN,KLF6,LBH,MYC,NFKB2,NFKBIA,PROM1,RELB,SERPINE1,SPHK1,STAR,TLR2,TRAF1,ZFP36 | 281 (13) |
| Mapk | NA | group | NA | 0.00e+00 | 0.0e+00 | APLN,BCL2,BCL2L1,CCND1,CDKN1A,CFLAR,DBP,HPGD,IRS1,ITGB7,JUN,LEP,MYC,NR3C1,Peg3,PER1,PPARD,PRF1,S100A10 | 379 (22) |
| gossypin | NA | chemical - endogenous non-mammalian | NA | 0.00e+00 | 0.0e+00 | BCL2,BCL2L1,CCND1,CFLAR,MYC,TRAF1 | 264 (9) |
| gambogic acid | NA | chemical - endogenous non-mammalian | NA | 0.00e+00 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,MYC,TRAF1 | 306 (14) |
| alizarin | NA | chemical toxicant | NA | 0.00e+00 | 0.0e+00 | BCL2,BCL2L1,CCND1,MYC | 321 (15) |
| LYN | -2.00e-01 | kinase | NA | 0.00e+00 | 0.0e+00 | BCL2,CCL4,CD22,CDKN1A,CFLAR,MITF,MYC,NFKB2,NFKBIA,NFKBIZ,SPHK1,STAT5A,TRAF1,TRAF5 | 383 (16) |
| sucrose | NA | chemical - endogenous mammalian | NA | 0.00e+00 | 0.0e+00 | ACACB,ACLY,GPAM,LEP,MET,PLAGL1,SNAP25,SREBF1 | NA |
| NFYA | -5.10e-01 | transcription regulator | NA | 0.00e+00 | 0.0e+00 | ACLY,BCL2,CBS/LOC102724560,CDKN1A,CHEK2,FGFR2,GADD45A,GPAM,IRF1,JUN,OGG1,PIDD1 | 359 (18) |
| CDKN1B | -3.20e-01 | kinase | NA | 0.00e+00 | 0.0e+00 | BCL2,CCND1,CDKN1A,DUSP9,FLT3LG,GAB2,HSPB8,LGALS3,MEIS2,MYC,PPT2,RAB3A,SERPINE1,SMAD7,TCF7L2 | 367 (22) |
| RPS6KB2 | 3.10e-01 | kinase | NA | 0.00e+00 | 0.0e+00 | BCL2,BCL2L1,CXCL10,IRS1 | 181 (7) |
| MAP3K14 | -4.20e-01 | kinase | NA | 0.00e+00 | 0.0e+00 | BCL2L1,BIRC3,CFLAR,GADD45A,GBP5,IL1R2,NFKB2,NFKBIA,PDE3B,RELB,SREBF1 | 286 (12) |
| mir-378 | 6.00e-02 | microRNA | NA | 0.00e+00 | 0.0e+00 | FOXO1,FOXO3,MED13,SUFU | NA |
| SASH1 | 3.00e-01 | other | NA | 0.00e+00 | 0.0e+00 | CCL4,CXCL10,FGL2,HDC,IRF1,MERTK,MET,NFKBIZ,PML,TSC22D1 | 164 (7) |
| SETD2 | 3.30e-01 | enzyme | NA | 0.00e+00 | 0.0e+00 | AXIN2,CCND1,FOXO3,JUN,SERPINE1,SOX17,WNT5A | 372 (18) |
| ZBED6 | NA | transcription regulator | NA | 0.00e+00 | 0.0e+00 | DDIT4,KCTD1,MYBL1,ROCK2,SGK1,UPP1 | NA |
| trastuzumab | NA | biologic drug | NA | 0.00e+00 | 0.0e+00 | BCL2L1,CCND1,CDKN1A,LRIG1,MYC | 430 (22) |
| oligomycin | NA | chemical - endogenous non-mammalian | NA | 0.00e+00 | 0.0e+00 | BCL2,CXCL10,DDIT4,KDR | 424 (22) |
| EP4-D | NA | chemical reagent | NA | 0.00e+00 | 0.0e+00 | CARD11,CX3CL1,EGLN3,IKBKE,IL2RB,PRF1,TRAF6,ZBTB16 | NA |
| propylthiouracil | NA | chemical drug | NA | 0.00e+00 | 0.0e+00 | ALDH1A3,BTG2,CHD1,CORO1A,FMO3,GBP4,GLUL,GPC2,GRB7,JUN,MRC1,NRP1,Pcsk1,PROM1,RXRB,SLC16A10,SLC2A5,STAT5A,TPO | NA |
| NDN | 1.00e-01 | transcription regulator | NA | 0.00e+00 | 0.0e+00 | CDKN1A,MYC,NUCB2,PPARG | 334 (13) |
| galactose | NA | chemical - endogenous mammalian | NA | 0.00e+00 | 0.0e+00 | COX5A,SREBF1,THBS1,VDR | NA |
| CHD4 | -2.10e-01 | enzyme | NA | 0.00e+00 | 0.0e+00 | ADORA1,CDKN1A,CHEK2,JAK3,JUN,LOX,RIPK4,SQLE,STAT5A | 181 (6) |
| SYVN1 | 2.90e-01 | transporter | NA | 0.00e+00 | 0.0e+00 | BHLHE40,CCND1,FANCG,IRAK2,NFKB2,PLD2,PPP1R15B,SLC12A3,SLC16A1,SLC3A2,SLC6A6,SLC7A5,TFRC,TRERF1 | 290 (7) |
| SOD1 | 3.10e-01 | enzyme | NA | 0.00e+00 | 1.0e-02 | APEX1,ATF4,BCL2,BCL2L1,CCND1,CCNT1,CFLAR,FGF10,HSPB8,JUN,LIMK1,MET,Mt1,MYBL1,NFIL3,OAS2,PRDX6,RBM3,SCN1B,TFRC,VAPA,VIP | 386 (18) |
| PPP3CB | 1.20e-01 | phosphatase | NA | 0.00e+00 | 1.0e-02 | CDKN1A,FOXO3,GADD45A,IRS1 | 386 (17) |
| APOC1 | NA | transporter | NA | 0.00e+00 | 1.0e-02 | BCL2,FGF2,FSCN1,MYC | 440 (19) |
| IFNGR1 | 4.90e-01 | transmembrane receptor | NA | 0.00e+00 | 1.0e-02 | A3GALT2,CCL4,CD38,CXCL10,FSCN1,GBP5,IL1R2,IL6R,IRF1,MITF,NFKB2,PNPLA7,TRAF1,TRAF6,UBAC1 | 377 (15) |
| RACK1 | 7.00e-02 | enzyme | NA | 0.00e+00 | 1.0e-02 | ADCYAP1R1,BCL2L1,CDKN1A,MYC,NR3C2 | 364 (21) |
| cytarabine | NA | chemical drug | NA | 0.00e+00 | 1.0e-02 | BCL2,CD180,CDKN1A,GADD45A,MCC,PRF1,TLR2,TP53INP1 | 397 (22) |
| PKNOX2 | -1.00e-01 | transcription regulator | NA | 0.00e+00 | 1.0e-02 | BTG2,CDKN1A,GADD45A,PIDD1 | NA |
| SMYD3 | NA | enzyme | NA | 0.00e+00 | 1.0e-02 | CEBPD,NEURL1,PIK3CB,SH2B2 | NA |
| DOCK8 | -4.80e-01 | other | NA | 0.00e+00 | 1.0e-02 | CCL4,CXCL10,FGL2,HDC,IRF1,MERTK,NFKBIZ,TSC22D1 | NA |
| EIF3E | NA | translation regulator | NA | 0.00e+00 | 1.0e-02 | BCL2L1,CCND1,EPAS1,FGF2,THBS1,TOP3A | NA |
| tranylcypromine | NA | chemical drug | NA | 0.00e+00 | 1.0e-02 | CDKN1A,CXCL10,NFATC1,PDE4A | NA |
| ML290 | NA | chemical reagent | NA | 0.00e+00 | 2.0e-02 | INHBB,IRAK2,NFKB2,NOG | NA |
| CTR9 | -1.50e-01 | other | NA | 0.00e+00 | 2.0e-02 | EPAS1,IGFBP4,MYC,TP53INP1 | NA |
| LCAT | 0.00e+00 | enzyme | NA | 0.00e+00 | 2.0e-02 | AXIN2,CCND1,MYC,PPARG | NA |
| LILRB1 | NA | transmembrane receptor | NA | 0.00e+00 | 2.0e-02 | BCL2,FGFR3,FOXO3,ST3GAL6 | NA |
| SP110 | -1.10e-01 | transcription regulator | NA | 0.00e+00 | 2.0e-02 | CXCL10,CXCL11,CYLD,IL6R,MTHFR,MYC,NFIL3,PPARG,ROCK2,STAT5A,TBX3,TCF3 | NA |
| PD184352 | NA | chemical drug | NA | 0.00e+00 | 2.0e-02 | BCL2,BCL2L1,CCND1,CFLAR | NA |
| HNRNPU | -9.00e-02 | transporter | NA | 0.00e+00 | 2.0e-02 | FGFR2,INHBB,LRTM2,MYC,NFKB2,Oasl2,TYRO3 | NA |
| SPRY1 | NA | other | NA | 0.00e+00 | 2.0e-02 | AXIN2,FGF10,FGFR3,LOX | NA |
| PLK2 | -6.40e-01 | kinase | NA | 0.00e+00 | 2.0e-02 | CXCL10,FGL2,IRF1,MERTK | NA |
| CCR2 | NA | G-protein coupled receptor | NA | 0.00e+00 | 3.0e-02 | CCL24,CCL4,COL12A1,CSF3,CX3CL1,CXCL10,ITGAL,P4HA1,TGM2,THBS1 | NA |
| PLK4 | 1.10e-01 | kinase | NA | 0.00e+00 | 3.0e-02 | CXCL10,FGL2,IRF1,MERTK | NA |
| calyculin A | NA | chemical toxicant | NA | 0.00e+00 | 3.0e-02 | CCND1,CDKN1A,SLC12A3,TGM2 | NA |
| ADA | -1.00e-01 | enzyme | NA | 0.00e+00 | 3.0e-02 | ADORA1,CCL24,DCK,SERPINE1 | NA |
| CBFA2T3 | 0.00e+00 | transcription regulator | NA | 0.00e+00 | 3.0e-02 | AGT,CD38,IRF6,KLB,LMX1A,OVOL1,TPH1 | NA |
| 1-(ethylthio)-4-(2-phenylethyl)-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1’-cyclohexan]-5(7H)-one | NA | chemical reagent | NA | 0.00e+00 | 4.0e-02 | FGF2,FGFR2,GMNN,LLGL2,NFKB2,TEAD2 | NA |
| bilirubin | NA | chemical - endogenous mammalian | NA | 0.00e+00 | 4.0e-02 | ADRB3,ATF4,CCND1,CYP2B6 | NA |
| SLC22A5 | -7.00e-02 | transporter | NA | 0.00e+00 | 4.0e-02 | CDKN1A,ITGB7,NOG,SMURF1 | NA |
| oltipraz | NA | chemical drug | NA | 0.00e+00 | 4.0e-02 | ACE2,AGT,MAS1,TRPC3 | NA |
| pravastatin | NA | chemical drug | NA | 0.00e+00 | 5.0e-02 | ADCYAP1R1,CRP,CYP2B6,Madcam1,PGF,SDC4 | NA |
| lipopolysaccharide | NA | chemical drug | NA | -1.00e-02 | 0.0e+00 | ACE2,ACLY,ACVR1,ADAMTS1,ADORA1,AGT,AGTR1,ALOX12,APEX1,APLNR,APOBEC1,ARL4A,ARRDC3,ASAP3,ATF4,ATG7,AXIN2,BACH2,BCL2,BCL2L1,BCL9,BIRC3,BTG1,CARD11,CBLB,CCL24,CCL4,CCND1,CD180,CD22,CD300LF,CD38,CD83,CD8A,CDC42EP2,CDKN1A,CEBPD,CFLAR,CISH,COL12A1,CORO1A,CREB3L2,CRHR2,CRP,CSF2RB,CSF3,CSF3R,CUL5,CX3CL1,CX3CR1,CXCL10,CXCL11,CYP2B6,DDIT4,DHX58,DTX3L,EDEM1,EGLN3,ELK3,ELL2,EPAS1,EPHX2,ETV6,FGF2,FGL2,FOXO1,FSCN1,GADD45A,GADD45G,GBP2,GBP4,GBP5,GJA5,GLP2R,GNA15,GNL3,GPR34,H3-3A/H3-3B,HDC,HK2,HPGD,HSD11B1,HSD11B2,HUS1,IDH1,IFI44L,Ifi47,IFRD1,IGFBP4,Igtp,IKBKE,IL1R2,IL1RN,IL2RB,IL6R,INHBB,IRAK2,IRF1,Irgm1,ITGAL,ITGB7,JAK3,JUN,KCNMB4,KDR,KLF4,KLF6,LDB2,LEP,LGALS3,LOX,LPIN2,LTB4R,LYVE1,MAFF,MAP3K6,MAPK6,MED13,MERTK,MET,MGST2,MRC1,MST1R,Mt1,MTHFD2,MYC,NAMPT,NDRG1,NFATC1,NFIL3,NFKB2,NFKBIA,NFKBIZ,NOD1,NR3C1,NRARP,NRP1,NRP2,OAS2,Oasl2,OTUD1,P4HA1,PARP11,PDE3B,PDK4,PENK,PIDD1,PIK3AP1,PIK3CG,PLEK,PLIN4,PLK2,PML,PPARD,PPARG,PPP1R13B,PSMD8,PTPN11,PTPRB,PTPRO,PYCARD,RAB27A,RALGDS,RASGEF1B,RDH13,RELB,RGS16,RND3,RORA,RXRB,SAMHD1,SAT1,SDC4,SEC24D,SERPINE1,SH2B2,SIPA1,SIRPA,SKIL,SLC15A3,SLC16A10,SLC3A2,SLC6A6,SLC7A5,SMAD7,SOX17,SPHK1,SREBF1,SSBP3,STAR,STAT5A,STX2,TAP1,TCF3,TCF7L2,TELO2,TFEB,TFRC,TGM2,THBS1,TIPARP,TLR2,TNK2,TRAF1,TRAF6,TRIB1,TSC22D1,TYK2,UPP1,VDR,VIP,VIPR2,WEE1,WNT5A,ZBTB16,ZFP36,ZNFX1 | 465 (17) |
| SPP1 | 5.20e-01 | cytokine | NA | -1.00e-02 | 3.0e-02 | BCL2,BCL2L1,CCL4,CCND1,CDKN1A,FGFR2,GATA6,HAS2,JUN,LOX,MET,MYC,PPARG,SERPINE1,SLIT1 | NA |
| VDR | 1.00e+00 | transcription regulator | NA | -1.00e-02 | 0.0e+00 | AGT,AGTR1,BCL2,BCL2L1,CCND1,CD38,CDKN1A,CISH,CXCL10,CYP2B6,GADD45A,GADD45G,GATA6,HK2,IFI44L,IL1RN,ITGB7,JUN,LBH,LEP,MYC,NFATC1,PDLIM2,PPARG,RELB,SREBF1,TCF3,TLR2,TMPRSS2,TPH1,VDR | 345 (21) |
| IL13 | NA | cytokine | NA | -1.00e-02 | 0.0e+00 | ACE2,ADORA1,AMPD2,BCL2L1,CCL24,CCL4,CISH,CX3CL1,CXCL10,CYSLTR1,EPAS1,FGFR3,GATA6,HDC,HSD11B1,IL1R2,IL1RN,JUN,KLF4,KLF6,LILRB3,MERTK,MRC1,NFATC1,PDLIM2,PPARG,SERPINE1,SLC26A6,SPHK1,ST3GAL6,TFRC,TGM2,THBS1,TYRO3,WNT5A | 434 (18) |
| dehydroisoandrosterone | NA | chemical - endogenous mammalian | NA | -2.00e-02 | 0.0e+00 | BCL2,CCND1,CYP2B6,FKBP5,HSD11B1,LGALS3,MYC,NFKBIA,PPARG,PRDX6,TMPRSS2 | 448 (25) |
| ciglitazone | NA | chemical drug | NA | -2.00e-02 | 0.0e+00 | AGT,BCL2,BCL2L1,CCND1,CDKN1A,CFLAR,GAL,GATA6,GRB7,MITF,NFKBIA,NOG,PPARG,SERPINE1 | 334 (17) |
| miR-34a-5p (and other miRNAs w/seed GGCAGUG) | NA | mature microRNA | NA | -2.00e-02 | 1.0e-02 | AXIN2,BCL2,BVES,CCND1,CDKN1A,KLF4,MET,MYC,PIK3CB,PPARG,THBS1,TP53INP1,TRAM2 | NA |
| haloperidol | NA | chemical drug | NA | -2.00e-02 | 4.0e-02 | BCL2,FGF2,Klf16,Pcsk1,PENK,PER1,SCN1B,WNT5A | NA |
| ESR1 | -6.70e-01 | ligand-dependent nuclear receptor | NA | -3.00e-02 | 0.0e+00 | ACLY,ADH1C,ADORA1,AGT,APEX1,ARRDC3,AXIN2,BCL2,BCL2L1,BCLAF1,BIRC3,BMPR2,CA12,CARD14,CCL4,CCND1,CD83,CDC42EP2,CDKN1A,CEBPD,CEP70,CHEK2,CISH,CLSPN,DDIT4,DUSP9,ENY2,FADD,FGF10,FGFR2,FLT3LG,FOXO1,FRAT2,GADD45G,GAL,GPAM,GPSM2,GRIA2,HIP1R,HOMER3,HOOK2,HOXC6,IFI44L,IFRD1,IGFBP4,IKBKE,IMPDH2,INHBB,IRAK2,IRF1,IRS1,IRS2,JAK3,JUN,LEP,LIMA1,LTB4R,MAP3K4,MAP7,MARK1,MCF2L,MET,MST1,MST1R,MYC,NFATC1,NFKB2,NFKBIA,NR1D1,OTUB2,PDE4A,PDE7A,PDK4,PLXNA2,PPARD,PPARG,PROM1,PTPN4,RAB27A,RDH16,RELB,RGS16,RND3,SAMHD1,SCN1B,SERPINE1,SGK1,SLC16A1,SLC3A2,SLC6A6,SLC7A1,SLC7A5,SLC7A8,SMURF1,STAR,STAT5A,SUFU,TAX1BP1,TCF7L2,TFRC,TGM2,TOB1,TP53I11,TRIB1,TYK2,VDR,VIP,WEE1 | 504 (21) |
| miR-124-3p (and other miRNAs w/seed AAGGCAC) | NA | mature microRNA | NA | -3.00e-02 | 0.0e+00 | ALDH9A1,CREB3L2,ELK3,HDAC5,LGALS3,MDFIC,MYO10,NFATC1,NR3C2,PARP16,PGF,RBM47,SENP8,SLC15A4,SLC16A1,SLC25A30,STX2,SURF4,TEAD1,TRAF6,TTC7A,USP49,ZBED3 | NA |
| iron | NA | chemical - endogenous mammalian | NA | -3.00e-02 | 0.0e+00 | CCND1,CDKN1A,EIF3A,FTL,GADD45A,GADD45G,Mt1,NDRG1,TFRC | 398 (23) |
| Jnk | NA | group | NA | -4.00e-02 | 0.0e+00 | ADARB1,AGT,APLN,ATG7,BCL2L1,BIRC3,BTG1,CCL4,CCND1,CD83,CFLAR,GADD45A,ITGB7,JUN,KLF6,MRC1,MYC,PPARD,SERPINE1,TGM2,TINAGL1,TRPC3,ZFP36 | 415 (18) |
| ITGB3 | -4.00e-01 | transmembrane receptor | NA | -4.00e-02 | 3.0e-02 | ACLY,BCL2,BCL2L1,HAS2,KDR,SERPINE1,SMAD7 | NA |
| THRA | 7.00e-02 | ligand-dependent nuclear receptor | NA | -4.00e-02 | 2.0e-02 | ATF4,CCND1,CDKN1A,CIRBP,CXCL10,FGFR3,IRF1,JUN,PENK,PPARG,PROM1,SERPINE1,SREBF1,TOMM20 | NA |
| hydrocortisone | NA | chemical - endogenous mammalian | NA | -4.00e-02 | 0.0e+00 | BCLAF1,BMPR2,CCND1,CEBPD,ERRFI1,FGF2,GLUL,H6PD,HSD11B1,IGFBP4,LOX,MAP3K4,Mt1,NFKBIA,NR3C1,PPARG,PTPN4,SEMA6A,SERPINE1,STAT5A,STX1A,TLR2,TP53I11 | 431 (18) |
| CpG oligonucleotide | NA | chemical drug | NA | -5.00e-02 | 3.0e-02 | BCL2,CCL4,CD83,CXCL10,MYC,NFKBIZ,OAS2,Oasl2,RASSF4,SERPINE1,SLC7A5,TFRC,THBS1,TLR2 | NA |
| bardoxolone | NA | chemical drug | NA | -5.00e-02 | 0.0e+00 | BCL2L1,CCND1,CDKN1A,CFLAR,IRS1,NFKBIA | 372 (23) |
| PROX1 | -2.90e-01 | transcription regulator | NA | -5.00e-02 | 1.0e-02 | FGFR3,FGFR4,KDR,LYVE1,NRP1,NT5E | NA |
| benzyl isothiocyanate | NA | chemical - endogenous non-mammalian | NA | -5.00e-02 | 0.0e+00 | BCL2,BCL2L1,CCND1,MET,MST1R,MYC,SERPINE1 | 377 (24) |
| Gsk3 | NA | group | NA | -5.00e-02 | 0.0e+00 | ATF4,BCL2,CCND1,CFLAR,FSCN1,IRS1,JUN,KDR,MYC,PPARG,SREBF1 | 456 (22) |
| CIP2A | NA | other | NA | -6.00e-02 | 3.0e-02 | BCL2,GADD45A,HK2,MYC,PDK4,PTPRB,SAT1 | NA |
| fluoxetine | NA | chemical drug | NA | -7.00e-02 | 0.0e+00 | ADARB1,BCL2L1,FGF2,MITF,MYC,NR3C1,NR3C2,PDE4A,S100A10,TPH1 | 419 (23) |
| Fcer1 | NA | complex | NA | -7.00e-02 | 1.0e-02 | CCL4,CD83,CFLAR,IL1RN,JUN,MRC1,NFATC1,SPHK1 | 378 (19) |
| MK2206 | NA | chemical drug | NA | -7.00e-02 | 0.0e+00 | ATF4,BCL2,CCND1,FOXO1,HK2,MYC,SREBF1 | 399 (24) |
| TLR9 | 3.20e-01 | transmembrane receptor | NA | -7.00e-02 | 0.0e+00 | BCL2,BCL2L1,CCL4,CCND1,CD38,CD83,CISH,CSF3,CXCL10,FLT3LG,IFI44L,IRF1,MYC,NAMPT,NFKBIZ,OAS2,Oasl2,PYCARD,RAB7B,SERPINE1,SPHK1 | 347 (17) |
| PRKCQ | -4.50e-01 | kinase | NA | -7.00e-02 | 2.0e-02 | BCL2L1,CCND1,CDKN1A,ITGAL,NFKB2 | NA |
| HDAC3 | 1.00e-02 | transcription regulator | NA | -8.00e-02 | 0.0e+00 | ACACB,BIRC3,CCND1,CDKN1A,CXCL10,GDF11,GPAM,HK2,MYC,NFATC1,NFKBIA,RELB,SERPINE1,SMAD7 | 288 (18) |
| Salmonella enterica serotype abortus equi lipopolysaccharide | NA | chemical toxicant | NA | -8.00e-02 | 0.0e+00 | ABL2,BIRC3,CCL4,CFLAR,CSF3,GADD45A,HECW2,HS3ST3B1,IRF1,MAFF,MAP3K4,NFKBIZ,SYNPO2,THBS1,TRAF1,WNT5A | 436 (21) |
| NPC1 | -1.60e-01 | transporter | NA | -9.00e-02 | 0.0e+00 | ATF4,ATG7,CCND1,CD22,CD8A,CX3CR1,GPR34,KLF4,LGALS3,MERTK,MMP15,MRC1,PI4K2A,PLIN4,SREBF1,TAP1 | 328 (25) |
| CYP19A1 | NA | enzyme | NA | -9.00e-02 | 0.0e+00 | BCL2,CCND1,CXCL10,FAM107A,FGF2,FKBP5,GBP2,HSD11B2,IRS1,JUN,LEP,PPARG,S100A10 | 367 (25) |
| eicosapentenoic acid | NA | chemical drug | NA | -9.00e-02 | 0.0e+00 | BCL2L1,CD83,CEBPD,IL1R2,IMPA2,JUN,LEP,MRC1,PDK4,PPARG,PROM1,SERPINE1,SREBF1 | 409 (22) |
| PLD1 | -4.60e-01 | enzyme | NA | -1.00e-01 | 2.0e-02 | BCL2,MYC,Pmaip1,PROM1 | NA |
| SAA1 | NA | transporter | NA | -1.00e-01 | 0.0e+00 | BCL2,CCL4,CCND1,CSF3,CXCL10,IL1RN,MRC1,PPARG,SREBF1 | 371 (15) |
| Raf | NA | group | NA | -1.00e-01 | 0.0e+00 | CCND1,CDKN1A,HAS2,JUN,MAFF,MYC,RND3,SEMA6A,TPO | 353 (20) |
| TFE3 | -2.70e-01 | transcription regulator | NA | -1.00e-01 | 5.0e-02 | HK2,IRS1,IRS2,PPARG,SERPINE1,SMAD7 | NA |
| prostaglandin D2 | NA | chemical - endogenous mammalian | NA | -1.00e-01 | 0.0e+00 | CCND1,CXCL10,EPAS1,HAS2,HAS3,NFATC1,NRP1,PPARG,SDC4,VDR | 370 (18) |
| Stat5 dimer | NA | complex | NA | -1.10e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,MYC,TLR2 | NA |
| alpelisib | NA | chemical drug | NA | -1.10e-01 | 1.0e-02 | BCL2L1,FOXO3,NR3C1,TGM2 | 294 (11) |
| NFkB (complex) | NA | complex | NA | -1.10e-01 | 0.0e+00 | AGT,ALDH1A3,BCL2,BCL2L1,BIRC3,CCL4,CCND1,CD83,CDKN1A,CEBPD,CFLAR,CGREF1,CRP,CSF3,CX3CL1,CXCL10,CXCL11,CYLD,DBP,DBT,EDNRB,ELL2,EPAS1,FGF2,GADD45A,GBP2,GPR34,HAS2,HIF3A,IKBKE,IL1RN,IRF1,ITGAL,JUN,KCND3,KDR,Madcam1,MFHAS1,MST1R,MYBL1,MYC,NAMPT,NFKB2,NFKBIA,NFKBIZ,NR1D1,Pcsk1,PLK2,PPARG,RELB,RGS16,SDC4,SERPINE1,SLC12A7,SLC2A5,SLC7A1,SLC7A5,SMAD7,STAT5A,TAP1,TFRC,TGM2,TLR2,TPO,TRAF1,TRPC3,WNT5A,XRCC6,ZFP36 | 407 (15) |
| TRAF3 | -1.20e-01 | enzyme | NA | -1.10e-01 | 1.0e-02 | BIRC3,CXCL10,GPR34,IL2RB,MET,NDRG1,NFKB2,NFKBIA,PIP5K1B,RELB,ST8SIA6 | 292 (17) |
| rotenone | NA | chemical toxicant | NA | -1.10e-01 | 1.0e-02 | AGT,ATF4,BIRC3,CCND1,CFLAR,GADD45G,KDR,SLC16A1 | NA |
| PPARGC1A | -8.00e-02 | transcription regulator | NA | -1.10e-01 | 0.0e+00 | ACACB,ADAMTS1,AGT,BLM,BMPER,BNIP3,CDKN1A,CEBPD,COX5A,CXCL10,CYP2B6,EPAS1,FANCG,FDPS,GDF11,GPAM,HK2,IL1R2,IL1RN,INHBB,IRS1,IRS2,MITF,MMP15,MYC,NFKB2,NFKBIA,NFKBIZ,PCSK5,PDK4,PPARG,SEMA6A,SLC19A1,SLC25A25,SMAD7,SREBF1,STAR | 401 (21) |
| methyl-beta-cyclodextrin | NA | chemical drug | NA | -1.20e-01 | 0.0e+00 | BCL2L1,CCND1,HAS2,MYC,PPARG,SERPINE1 | 352 (19) |
| Pka | NA | complex | NA | -1.20e-01 | 1.0e-02 | CDKN1A,CXCL10,HAS2,IRF1,JUN,KLF6,LEP,PDE4D,PENK,SGK1,SREBF1,STAR,TCF3 | 296 (20) |
| diethylnitrosamine | NA | chemical toxicant | NA | -1.20e-01 | 4.0e-02 | BCL2L1,BIRC3,CCND1,CDKN1A,CXCL10,JUN,MET,Mt1,MYC,OGG1,PROM1,TRPV2 | NA |
| IFN Beta | NA | group | NA | -1.20e-01 | 0.0e+00 | ACE2,BCL2,BCL2L1,BTG2,CD22,CD83,CDKN1A,CEBPD,CXCL10,CXCL11,DHX58,FKBP5,IL1RN,IRF1,MYC,OAS2,QPRT,SERPINE1,SPHK1,TAP1,THBS1,TRIM14,VDR | 381 (18) |
| BCL6 | 2.00e-01 | transcription regulator | NA | -1.20e-01 | 0.0e+00 | BACH2,BCL2,BCL2L1,CCL4,CCND1,CDKN1A,CISH,CXCL10,FGF2,GABPB1,GADD45A,IL2RB,IL6R,IRF1,KLF6,LBH,MAPK6,MITF,MRC1,MYC,NFATC1,PI4K2B,PIK3CG,Pmaip1,PTPRO,SERPINE1,SH3PXD2B,STXBP4,TRIM2,UBA7 | 388 (18) |
| CREB3L3 | -4.00e-02 | transcription regulator | NA | -1.20e-01 | 1.0e-02 | CIDEC,CRP,CYP2B6,NFATC1,SMURF1 | NA |
| BMAL1 | NA | transcription regulator | NA | -1.30e-01 | 0.0e+00 | CRY1,DBP,EGLN3,GPAM,HK2,NFIL3,NR1D1,PER1,PER3,SREBF1,STAR,WEE1 | 221 (12) |
| Nfat (family) | NA | group | NA | -1.30e-01 | 0.0e+00 | BCL2,CCND1,CFLAR,CX3CL1,ELL2,KLF6,LBH,NUS1,PDE3B,PGM2L1,RELB,SDC4,SERPINE1,SLC7A1,TRAF1 | 391 (17) |
| Ciap | NA | group | NA | -1.30e-01 | 0.0e+00 | BCL2,BCL2L1,CCL4,CCND1,CSF3,MYC | 319 (11) |
| NOG | -1.81e+00 | growth factor | NA | -1.30e-01 | 1.0e-02 | CXXC5,HAS2,KDR,MITF,MYC,NOG,WNT5A | 303 (17) |
| N-[(2Z)-3-(4,5-dihydro-1,3-thiazol-2-yl)-1,3-thiazolidin-2-yl idene]-5H dibenzo[a,d][7]annulen-5-amine | NA | chemical reagent | NA | -1.30e-01 | 3.0e-02 | ADRB3,BCAR3,FGF2,MTHFD2,MYC,SERPINE1,TFRC,VIP | NA |
| pimagedine | NA | chemical drug | NA | -1.30e-01 | 3.0e-02 | BCL2,BCL2L1,CFLAR,CRP,SERPINE1 | NA |
| TRAF6 | 6.50e-01 | enzyme | NA | -1.30e-01 | 4.0e-02 | BIRC3,CRP,CSF3,CYLD,Madcam1,PAG1,RELB | NA |
| beta-carotene | NA | chemical - endogenous mammalian | NA | -1.30e-01 | 4.0e-02 | ARRDC3,FADS3,NR1D1,PPARG,SLC16A12 | NA |
| TFAP2A | -3.00e-01 | transcription regulator | NA | -1.30e-01 | 0.0e+00 | ADRA1D,BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,COL7A1,CX3CL1,FGFR4,KLF4,PAG1,PPARD,PPARG,PPP2R2A,SERPINE1,SLC19A1 | 363 (21) |
| 48s | NA | complex | NA | -1.30e-01 | 0.0e+00 | ATF4,BCL2,CCND1,MYC,SREBF1 | NA |
| mir-34 | NA | microRNA | NA | -1.30e-01 | 0.0e+00 | BCL2,BIRC3,CCDC71L,CCND1,EFNB1,HK2,KCNH1,MET,MYC,SATB2,SEMA4B,SOX17 | 401 (27) |
| PRKG1 | NA | kinase | NA | -1.30e-01 | 0.0e+00 | BCL2,CCND1,CDKN1A,PPARG,SERPINE1,THBS1 | 327 (22) |
| Ro41-5253 | NA | chemical reagent | NA | -1.30e-01 | 2.0e-02 | CD38,CDKN1A,IRF1,PPARG | NA |
| SPINT1 | 2.20e-01 | other | NA | -1.30e-01 | 0.0e+00 | IGFBP4,SOX17,TCF7L2,WNT5A | NA |
| ANGPT1 | -2.40e-01 | growth factor | NA | -1.30e-01 | 5.0e-02 | ADAMTS1,APLN,BCL2,BCL2L1,CCND1 | NA |
| IL5 | NA | cytokine | NA | -1.30e-01 | 0.0e+00 | ATF4,BCL2,BCL2L1,BNIP3,CDKN1A,CISH,CSF2RB,CSF3R,CX3CR1,CYSLTR1,EGLN3,ELL2,FGL2,GADD45A,GADD45G,GBP2,GBP4,GPAM,HIGD1A,IL1R2,IL6R,ITGB7,MAPK6,MKNK1,MYC,NDRG1,NFIL3,P4HA1,RBM3,SGK1,SLC7A5,UPP1 | 357 (23) |
| 10E,12Z-octadecadienoic acid | NA | chemical - endogenous mammalian | NA | -1.30e-01 | 1.0e-02 | APLN,ATF4,BCL2,CDK18,CITED1,ENDOU,FMO2,GDF5,HSD11B1,IL1RN,KLF14,NAMPT,PLK2,PPARG,SREBF1 | 345 (21) |
| PPARA | 6.00e-02 | ligand-dependent nuclear receptor | NA | -1.40e-01 | 3.0e-02 | ADRB3,ALDH9A1,APEX1,BCL2,BCL2L1,CCND1,CCNT1,CDKN1A,CDKN2C,CEBPD,CIDEC,CYP2B6,FDPS,GLUL,GPAM,IL1RN,MYC,NFKBIA,NR1D1,OGG1,PDK4,PLIN4,PPARD,PPARG,PRDX6,SAT1,SQLE,SREBF1,TFEB,TLR2 | NA |
| L-triiodothyronine | NA | chemical - endogenous mammalian | NA | -1.40e-01 | 0.0e+00 | AGT,AMD1,BCAR3,BCL2,BCL2L1,BTG2,CCND1,CDKN1A,CHD1,CIAPIN1,CMKLR1,COQ10B,COX5A,CYS1,DBP,DBT,ECE1,EPAS1,FDPS,FZD8,GBP4,GPCPD1,H2-T22,H6PD,HR,HSD11B1,IGFBP4,LEP,LGALS3,MYC,NR1D1,NT5E,PDK4,PER1,Pmaip1,PPARG,PRSS53,RGS16,SBK1,SERPINE1,SH2B2,SLC16A10,SLC46A3,SMAD7,SQLE,SREBF1,STAR,TCF3,TGM2,TMPRSS2,WIPF3 | 383 (20) |
| SPARC | 2.70e-01 | other | NA | -1.40e-01 | 2.0e-02 | BHLHE40,BLM,CEBPD,CIDEC,LYVE1,MBD4,NDRG1,PAG1,SERPINE1,TBX3,TRIM2 | NA |
| diallyl trisulfide | NA | chemical - endogenous non-mammalian | NA | -1.50e-01 | 2.0e-02 | BCL2,BCL2L1,CDKN1A,JUN | NA |
| PRNP | 2.30e-01 | other | NA | -1.50e-01 | 1.0e-02 | ATF4,BCL2,CCND1,IRS1,MYC,NFKBIA,PRND,SNAP25,TCF7L2 | 423 (22) |
| quinacrine | NA | chemical drug | NA | -1.50e-01 | 0.0e+00 | BCL2,BCL2L1,CDKN1A,CFLAR | 344 (19) |
| puromycin | NA | chemical - endogenous non-mammalian | NA | -1.50e-01 | 0.0e+00 | BCL2L1,CYP2B6,RBM3,SERPINE1,SKIL | 316 (13) |
| PECAM1 | NA | other | NA | -1.50e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,THBS1 | 361 (22) |
| CTSK | 5.60e-01 | peptidase | NA | -1.50e-01 | 0.0e+00 | BCL2,CDKN1A,PPARG,TLR2 | 338 (10) |
| PPP1R15A | NA | other | NA | -1.50e-01 | 1.0e-02 | ATF4,CCND1,GADD45A,SNAP25 | NA |
| MAP2K7 | 1.40e-01 | kinase | NA | -1.50e-01 | 1.0e-02 | BIRC3,CCND1,CDKN1A,CXCL10,MYC,PTPN11,VDR | NA |
| EIF4G2 | 8.00e-02 | translation regulator | NA | -1.50e-01 | 1.0e-02 | CDKN1A,JUN,KLF4,TBX3 | NA |
| miR-18a-5p (and other miRNAs w/seed AAGGUGC) | NA | mature microRNA | NA | -1.50e-01 | 2.0e-02 | AXIN2,CCND1,CDKN1A,THBS1 | NA |
| PRKCZ | -4.10e-01 | kinase | NA | -1.50e-01 | 2.0e-02 | BCL2,CCND1,JUN,MYC,NFKBIA | NA |
| ZNF768 | -4.30e-01 | other | NA | -1.50e-01 | 2.0e-02 | BTG2,GADD45A,PML,SERPINE1 | NA |
| PTPN2 | 4.60e-01 | phosphatase | NA | -1.50e-01 | 4.0e-02 | CCND1,JAK3,MET,TMEM26 | NA |
| carbohydrate | NA | chemical - endogenous mammalian | NA | -1.50e-01 | 4.0e-02 | ACACB,ACLY,LEP,SREBF1 | NA |
| XRCC5 | 1.10e-01 | enzyme | NA | -1.50e-01 | 5.0e-02 | CXCL10,MRC1,Mt1,TGM2 | NA |
| LPIN1 | 5.70e-01 | phosphatase | NA | -1.60e-01 | 1.0e-02 | CDKN1A,FDPS,LPIN2,PPARG,SREBF1 | 350 (19) |
| laquinimod | NA | chemical drug | NA | -1.60e-01 | 0.0e+00 | ADAMTS15,CX3CL1,FKBP5,GPT2,HDC,IL1R2,INHBB,MPZL2,PGF,PPP1R3G,RIPK4,SMIM3,SYT15,TIPARP,TPH1 | NA |
| DRD2 | -1.00e-02 | G-protein coupled receptor | NA | -1.70e-01 | 1.0e-02 | EDNRB,JUN,NFKB2,NFKBIA,PENK,RELB,SERPINE1,THBS1,TRAF1,TRAF6 | 322 (14) |
| phenylephrine | NA | chemical drug | NA | -1.70e-01 | 2.0e-02 | BCL2,EDNRA,EDNRB,JUN,KCND3,MYC,PDK4,PLAGL1,TFEB | NA |
| cuprizone | NA | chemical toxicant | NA | -1.70e-01 | 0.0e+00 | ASPA,BACH2,CCL4,CXCL10,FAM78A,FDPS,GLUL,GPR34,HVCN1,KLHL40,LGALS3,MPP7,PRDX6,PYCARD,RAP1GAP2,TFRC | NA |
| REL | 4.10e-01 | transcription regulator | NA | -1.70e-01 | 0.0e+00 | BACH2,BCL2,BCL2L1,CCL4,CCND1,CDKN1A,CXCL10,FOXO3,GPT2,IFT74,IRF6,JUN,KDR,MYC,NFATC1,NFKB2,NFKBIA,NRARP,PLK2,PYCARD,RELB,SLC25A27,SLC7A6,TTLL1 | 357 (17) |
| mir-27 | NA | microRNA | NA | -1.70e-01 | 2.0e-02 | ACACB,ACLY,EDNRA,FOXO1,MET,PPARG,SEMA6A,SREBF1 | NA |
| HNF4A | -2.00e-02 | transcription regulator | NA | -1.80e-01 | 0.0e+00 | ABCA6,ABHD10,ACLY,ACVR1,AGT,ATAT1,ATF4,ATP7B,AXIN2,BCL2L1,BCLAF1,BCS1L,BTG1,Btnl4/Btnl6,CBS/LOC102724560,CCND1,CCNT1,CDC42EP2,CDKN1A,CEBPD,CHEK2,CIDEC,CIR1,COQ10B,COQ8A,CRP,CRY1,CSPG5,CUL5,CYLD,CYP2B6,DBP,DBT,DCAF13,DCK,DDX49,DNAJC28,DTL,DTX3L,DUSP19,FBXL7,FDPS,FMN2,FMO1,FMO2,FMO3,FOXO1,GABRE,GADD45G,GATA6,GNB1L,GNL3,GRIK3,HPS6,HSD11B1,HUNK,IL2RB,IRF6,ITGAL,JUN,LGALS3,LIN7C,MAIP1,MAP7,MBD4,MGST2,MOV10,MPZL2,MST1,Mt1,MYC,NAMPT,NDRG1,NDUFA5,NPAT,NR1D1,NUAK1,OSBPL11,OVOL1,PAQR5,PCDH20,PCYT1A,PDK4,PELO,PITPNB,PLD2,PPARD,PPARG,PPFIBP1,PPP1R15B,PROM1,PSMD8,PTPN11,PTPN4,QTRT2,RASL12,RBM15,RBM28,RITA1,RORA,RPS18,RXRB,SAMHD1,SEC24D,SERPINE1,SGK1,SLC25A32,SLC7A6OS,SLIRP,SOX17,SREBF1,SRR,STAM,STOML1,SYBU,TAX1BP1,TBC1D15,TCF7L2,TFRC,TLE3,TRAF6,TRMT1L,TRMT6,UTP3,VMP1,WDCP,ZBED3,ZFP36,ZFP37,ZNF189 | 460 (25) |
| NR5A2 | -4.20e-01 | ligand-dependent nuclear receptor | NA | -1.80e-01 | 0.0e+00 | BCL2,CCND1,CDKN1A,CEBPD,CRP,CXCL10,GADD45G,GPT2,IL1RN,JUN,Mt1,MYC,STAR | 357 (23) |
| POU5F1 | NA | transcription regulator | NA | -1.80e-01 | 0.0e+00 | ACVR1,BCL2,BFAR,BIRC3,BMPER,BNIP3,BRAF,BTG1,CCND1,CDKN1A,CITED1,CXCL10,EN1,FADD,FBXO15,GADD45A,GADD45G,GATA6,GBP4,HK2,IRF6,IRS1,JARID2,KLF4,MYC,NRP1,Oasl2,OVOL1,PROM1,PYCARD,SIRPA,SMAD7,SOX17,TBX3,TEAD1,TEAD2,TRAF4,WEE1,WNT5A | 448 (24) |
| DAXX | -2.00e-01 | transcription regulator | NA | -1.90e-01 | 0.0e+00 | BCL2,CCND1,CDKN1A,FADD,IKBKE,NFKB2,SERPINE1 | 427 (22) |
| gamma-tocotrienol | NA | chemical drug | NA | -1.90e-01 | 0.0e+00 | BCL2L1,CCND1,CSF3,JUN,NFKBIA,TRAF6 | 301 (13) |
| NR1H2 | -1.60e-01 | ligand-dependent nuclear receptor | NA | -1.90e-01 | 0.0e+00 | AGT,CCL4,CD38,CRP,CSF3,CXCL10,FDPS,GBP4,HSD11B1,IL1RN,ITGAL,MRC1,NFKBIA,SLC16A10,SREBF1,STAR | 375 (26) |
| 3M-002 | NA | chemical reagent | NA | -2.00e-01 | 4.0e-02 | AGT,CCL4,CCND1,CD83,CXCL10,GJA5,GPR17,Milr1,MLPH,SLC12A3 | NA |
| arsenite | NA | chemical toxicant | NA | -2.00e-01 | 0.0e+00 | APEX1,ATF4,CCND1,CDKN1A,CYP2B6,GADD45A,HAS2,INHBB,IRF1,JUN,MAFF,MYC,SERPINE1,THBS1 | 396 (20) |
| TEAD4 | -6.00e-02 | transcription regulator | NA | -2.00e-01 | 0.0e+00 | CCND1,CDKN1A,CIDEC,EDNRA,FGFR2,FKBP5,IRF6,JUN,NFKBIA,NFKBIZ,NUAK1,OVOL1,PLK2,PPARG,PTPRO,RANBP1,SAMD5,THBS1 | 266 (14) |
| ILKAP | 2.00e-01 | phosphatase | NA | -2.00e-01 | 0.0e+00 | CCND1,FOXO1,HK2,MYC,NDRG1 | 357 (15) |
| PLA2G6 | -1.70e-01 | enzyme | NA | -2.00e-01 | 0.0e+00 | ALOX12,ATF4,BCL2L1,MRC1,PPARG | 374 (24) |
| MAC | NA | complex | NA | -2.00e-01 | 1.0e-02 | BCL2,IRF1,RGS16,THBS1,ZFP36 | NA |
| IL17F | NA | cytokine | NA | -2.00e-01 | 4.0e-02 | CSF3,CX3CL1,CXCL10,LEP,TRAF6 | NA |
| TRPM2 | -4.00e-01 | ion channel | NA | -2.00e-01 | 5.0e-02 | ATG7,BNIP3,EPAS1,FOXO3 | NA |
| PPARGC1B | 1.90e-01 | transcription regulator | NA | -2.00e-01 | 0.0e+00 | ACACB,CCND1,COX5A,EGLN3,FDPS,GPAM,GRB7,HK2,MITF,PDK4,SQLE | 290 (10) |
| palmitic acid | NA | chemical - endogenous mammalian | NA | -2.00e-01 | 0.0e+00 | ACLY,ADCYAP1R1,ATF4,ATG7,BCL2,BCL2L1,BIRC3,CCL4,CDKN1A,CFLAR,CXCL10,EGLN3,EPHX2,FDPS,FOXO1,HK2,HTR7,IL1RN,IL6R,IRAK2,IRS1,IRS2,JUN,KLF4,LEP,MET,Mt1,NDUFA5,NFKB2,NFKBIA,PDK4,PPARD,PPARG,SERPINE1,SPHK1,SREBF1,TFRC,TLR2,VIPR2,WEE1 | 463 (22) |
| CNTF | 3.10e-01 | cytokine | NA | -2.00e-01 | 0.0e+00 | CEBPD,CISH,CRP,FGF2,HVCN1,IL1RN,IRF1,IRS1,KLF4,LDB2,LEP,LGALS3,NAMPT,Oasl2,PENK,SATB2,SLC15A3,SLC16A1,SREBF1,STX1B,TAP1,TLR2,VIP,WNT5A,ZFP36 | 263 (15) |
| LEPR | -2.60e-01 | transmembrane receptor | NA | -2.00e-01 | 0.0e+00 | ACE2,ADRB3,BCL2,BCL2L1,BTG1,CFLAR,CREB3L2,EIF3A,GADD45G,GPAM,IL1R2,IL1RN,IRS2,LEP,NR3C2,PPARD,PPARG,PROM1,SERPINE1,SNAP25,SREBF1,TCF7L2,TP53INP1 | 435 (21) |
| EIF4EBP2 | -1.00e-01 | translation regulator | NA | -2.00e-01 | 0.0e+00 | CEBPD,CXCL10,GRIA2,IL1RN,NFIL3,PPARG | 221 (11) |
| rosiglitazone | NA | chemical drug | NA | -2.10e-01 | 0.0e+00 | ACLY,ADAMTS1,ADRB3,AGT,AGTR1,BCL2,BMPR2,CCND1,CDKN1A,CIDEC,COX5A,CRP,CXCL10,CXCL11,CYP2B6,DDHD1,EDNRA,EGLN3,EPHX2,GBP2,GPAM,GRIA2,H6PD,HAS2,HCAR1,HPGD,HSD11B1,HSD11B2,IDH1,IL1RN,IRF1,IRS1,IRS2,ITGA1,ITGAL,KLB,KLF4,LEP,LOX,LTB4R,MET,MRC1,NR1D1,OAS2,PDK4,PENK,PPARG,PTPRO,ROCK2,RORA,SAMHD1,SERPINE1,SGK1,SLC27A6,SREBF1,THBS1,TSC22D1 | 403 (22) |
| TNFAIP3 | -3.30e-01 | enzyme | NA | -2.10e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CFLAR,CXCL10,MAP3K5,NFKBIA,SLC3A2,TFRC,TRAF6 | 340 (15) |
| BNIP3L | -8.00e-02 | other | NA | -2.10e-01 | 0.0e+00 | ANK1,BCL2L1,CD22,GADD45A,GPSM2,HK2,IL2RB,NFKB2,NFKBIA,TFRC | 305 (14) |
| RHOA | 0.00e+00 | enzyme | NA | -2.10e-01 | 0.0e+00 | AGT,BCL2,BCL2L1,CCND1,CDKN1A,CXCL10,CXCL11,IRF1,JUN,PIK3CG,RND3,ROCK2,SREBF1,STAR | 371 (21) |
| mir-3622 | NA | microRNA | NA | -2.20e-01 | 0.0e+00 | CCND1,CDKN1A,GADD45A,MYC | NA |
| SLC30A7 | 4.30e-01 | transporter | NA | -2.20e-01 | 1.0e-02 | ALOX12,EPHX2,IRS2,NT5E | NA |
| herbimycin | NA | chemical drug | NA | -2.20e-01 | 2.0e-02 | BCL2,BCL2L1,CCND1,IRS1,SERPINE1,SIRPA | NA |
| ritonavir | NA | chemical drug | NA | -2.20e-01 | 0.0e+00 | AXIN2,BCL2L1,C9orf72,CEP70,CYP2B6,FDPS,GBP2,HUNK,IFRD1,IKBKE,LEP,MET,MYC,PPARG,SQLE,SREBF1 | 372 (22) |
| TCF4 | 3.00e-01 | transcription regulator | NA | -2.20e-01 | 0.0e+00 | ARHGAP4,BACH2,BHLHE40,BNIP3,CD38,CDKN1A,CREB3L2,CSF3R,CSRNP1,DCK,EDEM1,FAM83A,FOXO1,GRB7,HSD11B1,IGFBP4,MITF,NOD1,PIK3C2B,PIK3CG,PLK2,PML,QTRT2,SEC24D,SLC12A7,SMAD7,TRAF5,ZNF467 | NA |
| dacinostat | NA | chemical drug | NA | -2.30e-01 | 0.0e+00 | BCL2,BCL2L1,CDKN1A,CEBPD,CFLAR | 376 (22) |
| aflatoxin B1 | NA | chemical - endogenous non-mammalian | NA | -2.30e-01 | 2.0e-02 | CDKN1A,CDKN2C,CLSPN,CX3CL1,DBP,EDNRB,EGLN3,Gabpb1,GRIA2,IRS2,KIFC3,MET,MTHFD1L,MYBL1,NDRG1,PRND,SQLE,STAR,STAT5A,VDR,XRCC6 | NA |
| S100A8 | 2.00e-02 | other | NA | -2.30e-01 | 1.0e-02 | ADAMTS1,APLN,BCL2,BCL2L1,BHLHE40,CCND1,CORO1A,CSF2RB,CXCL10,DDIT4,MCF2L,MYC,NFKBIA,PER1,PTPRO,SGK1 | 324 (20) |
| CCL11 | 2.10e-01 | cytokine | NA | -2.40e-01 | 1.0e-02 | BCL2,BCL2L1,CCL4,CXCL11,FGF10,ITGA1,LEP | NA |
| EFNA1 | 8.00e-02 | other | NA | -2.40e-01 | 3.0e-02 | BACH1,BACH2,FGF2,GATA6,NT5E,TCF3,TRIM2 | NA |
| SERPINE1 | 4.53e+00 | other | NA | -2.40e-01 | 1.0e-02 | CDKN1A,CSF3,CXCL10,DBP,FGF2,NFKB2,NFKBIA,PRF1,TLR2,ZFP36 | 444 (20) |
| PROC | -2.00e-02 | peptidase | NA | -2.40e-01 | 2.0e-02 | ACE2,AGT,NFKB2,SERPINE1,THBS1,TLR2 | NA |
| entolimod | NA | biologic drug | NA | -2.50e-01 | 1.0e-02 | CCL4,CXCL10,IRF1,NFKBIA,NFKBIZ | 160 (7) |
| TERT | -4.30e-01 | enzyme | NA | -2.50e-01 | 0.0e+00 | ALDH1A3,BNIP3,CCL24,CCND1,CDKN1A,CX3CL1,CXCL10,ELK3,FGF2,GATA6,IGFBP4,KLF4,MTHFD1L,MYC,NFKBIA,NUCKS1,OAS2,Oasl2,PROM1,RASA3,TBX3 | 385 (24) |
| E. coli serotype 0127B8 lipopolysaccharide | NA | chemical - endogenous non-mammalian | NA | -2.50e-01 | 0.0e+00 | ADGRG2,ADORA1,CXCL10,EDEM1,EDNRA,EDNRB,FAM107A,FGF2,GJA5,GLUL,GPR19,HAS2,Ifi47,IRF1,LGALS3,LOX,NFKBIA,SLC7A5,TLR2 | 358 (15) |
| miR-223-3p (miRNAs w/seed GUCAGUU) | NA | mature microRNA | NA | -2.50e-01 | 4.0e-02 | CCND1,FOXO1,FOXO3,IRS1 | NA |
| 27-hydroxycholesterol | NA | chemical - endogenous mammalian | NA | -2.60e-01 | 1.0e-02 | AGT,LEP,SREBF1,STAR | 448 (21) |
| LY294002 | NA | chemical drug | NA | -2.60e-01 | 0.0e+00 | ADAMTS1,ADH1C,ATF4,BCL2,BCL2L1,BHLHE40,BIRC3,CCND1,CD38,CD83,CDKN1A,CFLAR,CRP,CSF3,CXCL10,EPAS1,FGF2,FOXO1,GDF5,HAS2,HK2,IL1R2,IL1RN,INHBB,INPP4B,IRF1,IRS1,IRS2,JUN,LEP,MEIS2,MITF,MTHFD2,MYC,NDRG1,NFKBIA,PLK2,PPARD,PPARG,RAB3A,RCC1,RND3,SERPINE1,SGK1,SQLE,SREBF1,THBS1,TLR2,TPO,WNT5A,ZBTB16,ZFP36,ZNF184 | 420 (19) |
| NGF | -4.90e-01 | growth factor | NA | -2.60e-01 | 0.0e+00 | AXIN2,BCL2,BCL2L1,BTG2,CCL4,CCND1,CD83,CDKN1A,EGLN3,EPAS1,EPHA4,ERRFI1,GADD45A,GADD45G,GAL,GRIA2,HRH3,IFRD1,ITGA1,JUN,KCTD11,KLF4,MAFK,MYC,PLK2,PPARG,RASA3,SEMA6D,SMIM3,SNAP25,VIP,WNT5A,ZFP36 | 335 (20) |
| SREBF1 | -1.01e+00 | transcription regulator | NA | -2.70e-01 | 0.0e+00 | AACS,ACACB,ACLY,ADH1C,ALOX12,BCL2,BCL2L1,BHLHE40,CDKN1A,CEBPD,CXCL10,FDPS,FOXO1,GPAM,HK2,IDH1,IL1R2,IRS2,LEP,LGALS3,NFIL3,PCYT1A,PPARG,SERPINE1,SQLE,SREBF1,STAR,STX1A | 332 (17) |
| DDIT3 | -2.50e-01 | transcription regulator | NA | -2.70e-01 | 0.0e+00 | ATF4,BCL2,CEBPD,CFLAR,FOXO1,H6PD,IRAK2,LOX,MTHFD2,NDRG1,NFIL3,PER1,PPARG,STAT5A,STX1A,TGM2 | 430 (20) |
| KLF4 | 1.24e+00 | transcription regulator | NA | -2.70e-01 | 0.0e+00 | ACVR1,ADAMTS1,BCL2L1,BMPER,CCND1,CDKN1A,CITED1,GADD45A,GBP4,IRF6,IRS1,KDR,KLF4,MRC1,MYC,NRP1,Oasl2,OVOL1,PROM1,SERPINE1,SMAD7,SOX17,SPHK1,TBX3,TEAD1,TEAD2,THBS1,WNT5A | 384 (24) |
| EIF4EBP1 | -1.00e-02 | translation regulator | NA | -2.70e-01 | 0.0e+00 | ATF4,CCND1,CEBPD,CFLAR,CXCL10,HK2,IL1RN,LEP,MYC,NFIL3,PPARG | 366 (21) |
| IKK (complex) | NA | complex | NA | -2.80e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CFLAR,CXCL10,FANCA,FANCG,MYC | 314 (15) |
| BPIFB1 | -1.00e-02 | other | NA | -2.80e-01 | 0.0e+00 | BCL2,CCND1,JUN,MYC,NFKBIA,RASSF4 | 321 (22) |
| FGF4 | NA | growth factor | NA | -2.80e-01 | 0.0e+00 | CDKN1A,CSF3,FOXO1,FOXO3,SOX17 | 360 (16) |
| DCAF1 | 3.00e-02 | kinase | NA | -2.80e-01 | 1.0e-02 | CDKN1A,Pmaip1,TCF3,TGM2,TOB1 | NA |
| 1-palmitoyl-2-oleoylphosphatidylserine | NA | chemical - endogenous mammalian | NA | -2.80e-01 | 1.0e-02 | ACVR1,BMPR2,CCL4,CSF3,CXCL10 | NA |
| CA9 | -3.20e-01 | enzyme | NA | -2.80e-01 | 2.0e-02 | CA12,CSF3,EPAS1,SLC3A2,SLC6A6 | NA |
| dimethyl fumarate | NA | chemical drug | NA | -2.80e-01 | 3.0e-02 | JUN,KDR,MRC1,SERPINE1 | NA |
| CDC73 | 5.00e-01 | other | NA | -2.80e-01 | 0.0e+00 | CCND1,IGFBP4,IRF1,LGALS3,MYC | 399 (20) |
| CXCR2 | 1.60e-01 | G-protein coupled receptor | NA | -2.80e-01 | 0.0e+00 | BCL2,BCL2L1,CXCL10,IFRD1,ITGAL,PPARG | 311 (18) |
| ADRB | NA | group | NA | -2.90e-01 | 0.0e+00 | AACS,BHLHE40,BNIP3,CCND1,CDKN1A,CFLAR,CXCL10,DDIT4,FDPS,GADD45A,IDH1,JUN,KLF4,LBH,NFKBIA,NOD1,SLC6A9,TRAF1,WEE1 | 397 (22) |
| panobinostat | NA | chemical drug | NA | -2.90e-01 | 2.0e-02 | BCL2L1,CDKN1A,CEBPD,CXCL10,MITF,MYC,SERPINE1 | NA |
| MST1 | -6.50e-01 | growth factor | NA | -2.90e-01 | 2.0e-02 | BCL2L1,CCND1,IL1RN,MST1R | NA |
| GW7647 | NA | chemical drug | NA | -2.90e-01 | 3.0e-02 | HSD11B2,PDK4,SLC16A13,SREBF1 | NA |
| LUCAT1 | NA | other | NA | -2.90e-01 | 4.0e-02 | BCL2,CDKN1A,PDK4,SAT1 | NA |
| L 663536 | NA | chemical reagent | NA | -2.90e-01 | 0.0e+00 | BCL2,BCL2L1,FGF2,PPARD,PPARG | 343 (17) |
| ascorbic acid | NA | chemical - endogenous mammalian | NA | -2.90e-01 | 4.0e-02 | BCL2L1,CDKN1A,FTL,IGFBP4,ITGA1,NDRG1,PPARG,SERPINE1,TFRC | NA |
| MAPK8 | 3.80e-01 | kinase | NA | -3.00e-01 | 0.0e+00 | ADARB1,ATG7,BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,CRP,FOXO1,GADD45A,JUN,KLB,KLF6,LEP,MTHFR,MYC,NRP1,PPARD,TLR2,VDR,WNT5A,ZFP36 | 372 (18) |
| HMGA1 | -3.80e-01 | transcription regulator | NA | -3.00e-01 | 3.0e-02 | AGT,ARL4A,CCND1,CITED1,GNA15,IGFBP4,ITGAL,MYC,PPARG,SDC4,SEC24D,SOX17,TFEB,TMEM267 | NA |
| PPIF | 1.40e-01 | enzyme | NA | -3.00e-01 | 0.0e+00 | CCL4,CMKLR1,CX3CL1,CX3CR1,CXCL10,GDF5,HCAR1,INHBB,MEIS2,PDK4,WNT5A | NA |
| NCOR1 | 1.00e-01 | transcription regulator | NA | -3.10e-01 | 0.0e+00 | CCND1,CDKN1A,CSF3R,CXCL10,HAS2,HOXC6,NR1D1,OAS2,Oasl2,PDK4,PPARG,SREBF1,ZFP90 | 397 (24) |
| PRKCA | 1.70e-01 | kinase | NA | -3.10e-01 | 0.0e+00 | BCL2L1,CCND1,CDKN1A,CSF3,CXCL10,FOXO1,JUN,MYC,NFKBIA,PML,SERPINE1,SREBF1,STAR | 324 (20) |
| ZMIZ2 | 1.70e-01 | transcription regulator | NA | -3.10e-01 | 0.0e+00 | AXIN2,CCND1,JUN,MYC | NA |
| COL18A1 | 8.00e-02 | other | NA | -3.20e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CDKN2C,DDIT4,EDNRB,FGF2,HK2,JUN,KDR,MYC,NRP1,SERPINE1,THBS1 | 381 (22) |
| PNPLA2 | 4.00e-02 | enzyme | NA | -3.20e-01 | 1.0e-02 | BCL2,IRS1,LEP,MRC1,PDK4,PPARG,SLC16A1,SREBF1,ZNF423 | NA |
| CRH | NA | cytokine | NA | -3.20e-01 | 0.0e+00 | BCL2,HPGD,IL1RN,LEP,MRC1,SGK1,STAR,TPH1,VDR | 317 (22) |
| GDF9 | -2.30e-01 | growth factor | NA | -3.20e-01 | 2.0e-02 | HAS2,INHBB,LOX,SMAD7,STAR | NA |
| ADGRE2 | NA | other | NA | -3.30e-01 | 0.0e+00 | ALDH1A3,CCND1,CDKN1A,CFLAR,CXXC5,GLUL,JUN,MYC,WNT5A | 183 (7) |
| CSF | NA | group | NA | -3.30e-01 | 0.0e+00 | CCL4,CD22,IL1R2,IL1RN,IRAK2,PPARG,SERPINE1,TGM2,TRAF1 | NA |
| JAK1/2 | NA | group | NA | -3.30e-01 | 0.0e+00 | CA12,FAM107A,GBP2,GBP5,Ifi47,IRF1,KCNG1,RPRML,WIPF3 | 253 (7) |
| BTNL2 | NA | transmembrane receptor | NA | -3.30e-01 | 0.0e+00 | CDKN2C,FGL2,FGR,GBP4,GPR34,MYO10,NT5E,PDE7A,RALGDS | 234 (7) |
| RAG2 | NA | enzyme | NA | -3.30e-01 | 1.0e-02 | CMTM8,CXCL10,EPAS1,EPHA4,FGR,HDAC5,MET,NT5E,PLXNA2,TEAD1,TP53I11 | NA |
| DSCAM | 4.00e-02 | other | NA | -3.30e-01 | 2.0e-02 | ARHGAP4,CNTNAP1,GADD45G,IRS1,JAK3,KCND3,KLF4,MYC,RGMA | NA |
| torkinib | NA | chemical drug | NA | -3.40e-01 | 0.0e+00 | ACACB,ADAMTS1,BLM,BTG1,CCND1,CFLAR,CLSPN,COQ8A,CUL5,DDIT4,DTL,FOXO3,GMNN,GREM2,HAS2,IFRD1,IL1RN,IL6R,KLF6,MTHFD2,NUAK1,PDLIM2,PML,SDC4,SMAD7,XRCC2 | 290 (9) |
| Pam3-Cys-Ser-Lys4 | NA | chemical reagent | NA | -3.40e-01 | 0.0e+00 | BCL2L1,CCL4,CD180,CD83,CSF3,CX3CL1,CXCL10,CYLD,IRF1,ITGB7,JUN,NAMPT,NFKB2,NFKBIA,NFKBIZ,RELB,SERPINE1,SLC3A2,STAT5A,TLR2,TRAF1 | 359 (13) |
| PTGS2 | 4.00e-01 | enzyme | NA | -3.40e-01 | 0.0e+00 | ADCY5,AXIN2,BCL2,BCL2L1,BIRC3,CCL4,CCND1,CDKN1A,CDKN2C,CSF3,CXCL10,EDNRA,ITGAL,KDR,LEP,MRC1,MYC,PIK3CG,PPARG,PTGER1,PYCARD,STAR,TFRC,TGM2,TRAF1 | 435 (19) |
| curcumin | NA | chemical drug | NA | -3.40e-01 | 0.0e+00 | BANP,BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,CFLAR,CRP,FGF2,FTL,GLUL,IGFBP4,IRS1,JUN,KLB,LEP,MST1R,MYC,NAMPT,NFKBIA,OGG1,PDE3B,PGF,PPARG,RAB3A,SERPINE1,SMAD7,SREBF1,TFRC,TLR2,TOB1,TRAF1,UBA7,WEE1,XYLT1 | 370 (15) |
| ERG | -1.90e-01 | transcription regulator | NA | -3.40e-01 | 0.0e+00 | ALOX12,ARHGAP20,ARHGAP4,AXIN2,BIRC3,FKBP5,HPGD,IRS2,MAP3K5,MET,MYO10,NDRG1,NFIL3,PLEK,PSTPIP2,PTPN11,PTPN4,ROCK2,THBS1,TMPRSS2,TRIOBP,ZBTB16 | 320 (12) |
| LCOR | NA | transcription regulator | NA | -3.40e-01 | 0.0e+00 | ADORA1,CDKN1A,FKBP5,IGFBP4 | NA |
| GTF2I | -2.80e-01 | transcription regulator | NA | -3.40e-01 | 0.0e+00 | CCND1,CDKN1A,KDR,MYC,THBS1 | 367 (15) |
| DIO2 | 1.00e-02 | enzyme | NA | -3.40e-01 | 4.0e-02 | ASPA,CIRBP,DDIT4,GADD45G,GREM2,HR,KCND3,NT5C1A,PENK,RBM3,SLC10A6,SMIM3 | NA |
| ACLY | 8.00e-01 | enzyme | NA | -3.40e-01 | 4.0e-02 | COX5A,GPAM,MITF,SREBF1 | NA |
| PRKD | NA | group | NA | -3.40e-01 | 0.0e+00 | CCL4,CXCL10,HDAC5,PDK4,PPARD,STAR | 298 (10) |
| LPL | 4.70e-01 | enzyme | NA | -3.40e-01 | 0.0e+00 | BCL2,CX3CL1,FOXO3,IRS1,IRS2,PDK4,PPARG,THBS1 | 428 (27) |
| CD200R1 | 1.30e-01 | transmembrane receptor | NA | -3.40e-01 | 2.0e-02 | CSF2RB,IL2RB,JUN,MYC,NFKB2,NFKBIA,RELB | NA |
| ZEB2 | -3.70e-01 | transcription regulator | NA | -3.40e-01 | 4.0e-02 | CCND1,CDKN1A,CX3CR1,ESRP2,GAB2,MITF,MYC | NA |
| sunitinib | NA | chemical drug | NA | -3.40e-01 | 1.0e-02 | CDKN1A,COL7A1,CXCL10,ECE1,ITGA1,ITGAL,KDR,MET | NA |
| ADM | -8.00e-02 | other | NA | -3.40e-01 | 4.0e-02 | AGT,BCL2,FGF2,PENK,PPARG,SMAD7 | NA |
| salmonella minnesota R595 lipopolysaccharides | NA | chemical - endogenous non-mammalian | NA | -3.50e-01 | 0.0e+00 | CCL4,CD38,CD83,CEBPD,CFLAR,CXCL10,EDNRB,IKBKE,IRF1,JUN,MAFF,MDFIC,MET,NFKB2,NFKBIA,NFKBIZ,PSTPIP2,RELB,SAMHD1,SERPINE1,TLR2,TSC22D1 | 376 (14) |
| CLOCK | 1.10e-01 | transcription regulator | NA | -3.50e-01 | 0.0e+00 | BHLHE40,CCND1,CCNT1,CHTF8,DBP,DTX4,FAM107A,FKBP5,GADD45A,HAS2,IKBKE,KCND3,KCTD1,NFIL3,NR1D1,PER1,PER3,PICALM,SLC12A3,SRR,THBS1,WEE1,ZDHHC20 | 219 (10) |
| TLR7 | 5.70e-01 | transmembrane receptor | NA | -3.60e-01 | 1.0e-02 | AGT,BCL2,CCL4,CCND1,CD38,CD83,CDKN1A,CXCL10,FGF2,GPR17,IFI44L,IRF1,KCNH1,MLPH,NFKBIA,OAS2,SLC12A3 | NA |
| AZ-1 | NA | chemical - protease inhibitor | NA | -3.60e-01 | 2.0e-02 | CUL5,EIF4A1,JUN,MYC,PIK3C2A,RND3,TFRC,THBS1 | NA |
| KITLG | -1.90e-01 | growth factor | NA | -3.60e-01 | 0.0e+00 | BCL2,BCL2L1,BTG1,CCL4,CDKN1A,CIAPIN1,CISH,CSF3R,CX3CL1,EDNRB,GRIA2,IL1RN,KDR,NFKB2,NFKBIA,NR3C1,OGG1,PTPRR,TCF3,TPH1,WEE1 | 363 (20) |
| FGF21 | -3.70e-01 | growth factor | NA | -3.60e-01 | 0.0e+00 | ACLY,BCL2,CCND1,FGFR2,FGFR4,IRS2,KLB,LEP,PDK4,SERPINE1,SREBF1 | 371 (21) |
| E2F2 | -6.00e-02 | transcription regulator | NA | -3.60e-01 | 0.0e+00 | BCL2,CCND1,CDKN1A,CDKN2C,ECE1,FGFR2,MYC,NPAT,SERPINE1 | 391 (21) |
| IFNG | NA | cytokine | NA | -3.70e-01 | 0.0e+00 | ABCA6,ACE2,ACLY,ADCY5,ADGRG2,ADORA1,AGT,AGTR1,ALDH1A3,ALOX12,ATF4,BACH1,BACH2,BATF2,BCL2,BCL2L1,BIRC3,BTG1,CCL4,CCND1,CD38,CD83,CDKN1A,CEBPD,CFLAR,CIRBP,CISH,CORO1A,CSF2RB,CSF3,CX3CL1,CX3CR1,CXCL10,CXCL11,CXCL17,CYLD,DBP,DTX3L,DUSP9,ECE1,EDNRA,EDNRB,EGLN3,FAM107A,FGF2,FGL2,FHL2,FKBP5,FOXO1,FTL,GBP2,GBP4,GBP5,GJA5,GLUL,GPR19,H6PD,HAS2,HK2,IDH1,IFI44L,Ifi47,IFRD1,IGFBP4,Igtp,IKBKE,IL1RN,IL2RB,IL6R,IRAK2,IRF1,Irgm1,IRS1,IRS2,ITGAL,JAK3,JUN,KDR,KLF4,KLF6,LEP,LGALS3,LIMK1,LOX,LTB4R,MAFF,MERTK,MFSD2A,MITF,MRC1,MST1R,Mt1,MTHFD2,MYC,NAMPT,NFKB2,NFKBIA,NFKBIZ,NR1D1,NRP1,OAS2,Oasl2,Pcsk1,PDE3B,PDK4,PENK,PLEK,PML,PPARD,PPARG,PRF1,PROM1,PTPN11,PTPRB,QPRT,RAB27A,RELB,S100A10,SAMHD1,SDC4,SERPINE1,SLC12A3,SLC15A3,SLC6A6,SLC7A5,SMAD7,SMURF1,SNAP25,SQLE,SREBF1,STAR,TAP1,TCF7L2,TFRC,THBS1,TLR2,TPH1,TPO,TRAF6,TTC28,VDR,WNT5A,ZBTB16,ZFP36 | 377 (13) |
| PP2/AG1879 tyrosine kinase inhibitor | NA | chemical drug | NA | -3.70e-01 | 0.0e+00 | AGT,BCL2,BIRC3,CD38,CDKN1A,FGF2,FGR,GRIA2,PER1,SERPINE1 | 423 (24) |
| bardoxolone methyl | NA | chemical drug | NA | -3.70e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCL4,CCND1,CFLAR,MYC,TRAF1 | 358 (21) |
| 3-nitropropionic acid | NA | chemical toxicant | NA | -3.70e-01 | 3.0e-02 | BCL2,BCL2L1,FOXO3,JUN,MYC,PENK | NA |
| FOXC2 | -2.30e-01 | transcription regulator | NA | -3.80e-01 | 1.0e-02 | ADRB3,FGFR3,IRS1,IRS2,KDR,LEP,MET,PPARG,SATB2,WNT5A | 331 (11) |
| ID1 | 5.40e-01 | transcription regulator | NA | -3.80e-01 | 2.0e-02 | BCL2L1,CCND1,CDKN1A,DTX4,FGFR3,MYC,PROM1,THBS1 | NA |
| THZ2 | NA | chemical drug | NA | -3.80e-01 | 0.0e+00 | CCND1,CDKN1A,FHL2,IRAK2,MYC,TCF7L2,WEE1 | 187 (4) |
| FGF8 | NA | growth factor | NA | -3.80e-01 | 0.0e+00 | CCND1,CSF3,ELL2,EN1,ERRFI1,FGF10,FGFR2,FGFR4,LMX1A,NOG,RASD1,THBS1,VDR | 272 (16) |
| MSC | -8.00e-02 | transcription regulator | NA | -3.80e-01 | 2.0e-02 | CCL4,CHL1,IFI44L,PAG1,PCED1B,TRIB1,ZNF423 | NA |
| GRIN1 | 4.00e-02 | ion channel | NA | -3.80e-01 | 2.0e-02 | GAL,LOX,PENK,SEMA6A,SERPINE1,SMIM3,TP53I11 | NA |
| morphine | NA | chemical drug | NA | -3.80e-01 | 3.0e-02 | AXIN2,BCL2,CCND1,CDKN1A,KCNJ9,LEP,NR3C1,PENK,RGS20,THBS1,TLR2,TRAF6 | NA |
| GHRL | 7.00e-02 | growth factor | NA | -3.90e-01 | 4.0e-02 | BCL2,FOXO1,GPAM,LEP,PPARG,SREBF1,STAR | NA |
| CD40LG | 1.20e-01 | cytokine | NA | -3.90e-01 | 0.0e+00 | ARID4B,BCL2,BCL2L1,BIRC3,BNIP3,BTG1,CCL4,CD38,CD83,CD8A,CDKN1A,CFLAR,CXCL10,FFAR4,FSCN1,GADD45A,HK2,IL2RB,IRF1,ITGB7,JUN,MAP3K4,MYC,NAMPT,NFKB2,NFKBIA,PLEK,PML,RCC1,RELB,SERPINE1,STAT5A,TAP1,TFRC,TGM2,TRAF1,TRAF4,TRAF5,WNT5A,XRCC6 | 381 (14) |
| POLR2M | 8.00e-02 | other | NA | -3.90e-01 | 0.0e+00 | BTG2,CCND1,CDKN1A,DDIT4,PLK2 | NA |
| AKT2 | -3.00e-01 | kinase | NA | -3.90e-01 | 1.0e-02 | BCL2,CDKN1A,FOXO1,LEP,NFKB2,PPARG,SEMA6D | NA |
| ibuprofen | NA | chemical drug | NA | -3.90e-01 | 3.0e-02 | CCND1,COL12A1,EDNRB,EPAS1,PPARG | NA |
| choline fenofibrate | NA | chemical drug | NA | -3.90e-01 | 4.0e-02 | NFKBIA,NR1D1,PCSK5,SERPINE1 | NA |
| ABCB4 | NA | transporter | NA | -4.00e-01 | 2.0e-02 | BCL2L1,CXCL10,LGALS3,NFKB2,PROM1,SERPINE1 | NA |
| N-cor | NA | group | NA | -4.00e-01 | 0.0e+00 | ACACB,AXIN2,CCND1,CDKN1A,CIDEC,CRP,CXCL10,HK2,IDH1,INPP4B,NFATC1,SGK1,SREBF1,TRERF1,XYLT1 | 389 (24) |
| G protein alpha i | NA | group | NA | -4.10e-01 | 0.0e+00 | ADAMTS1,CEBPD,CMKLR1,CXCL10,GBP2,GBP4,GBP5,Igtp,Irgm1,KLF4,MAFF,Oasl2,SPHK1,STAR,TAP1,THBS1 | 382 (15) |
| USF1 | -2.80e-01 | transcription regulator | NA | -4.20e-01 | 2.0e-02 | AGT,APLN,CBS/LOC102724560,GPAM,HK2,Mt1,P4HA1,SERPINE1,SLC19A1 | NA |
| Bcl9-Cbp/p300-Ctnnb1-Lef/Tcf | NA | complex | NA | -4.20e-01 | 0.0e+00 | AXIN2,CCND1,MYC,PPARD,TCF7L2 | NA |
| UXT | 3.40e-01 | transcription regulator | NA | -4.20e-01 | 1.0e-02 | FKBP5,HPGD,HUS1,NFKBIA,SEC24D | NA |
| ID2 | 2.70e-01 | transcription regulator | NA | -4.20e-01 | 0.0e+00 | AXIN2,BCL2,BCL2L1,BIRC3,BTG2,CCND1,CD83,CDKN1A,CDKN2C,CSF2RB,DTX2,FGFR3,FLT3LG,FOXO1,FOXO3,GADD45G,IGFBP4,IL2RB,IL6R,INHBB,IRF6,ITGA1,KLF6,LRIG1,MYC,NFATC1,PIK3C2B,PROM1,RAPGEF4,RELB,RORA,SMAD7,TRAF1,TRAF4,TRAF5,ZBTB16 | 399 (26) |
| CREBBP | 3.10e-01 | transcription regulator | NA | -4.20e-01 | 0.0e+00 | AGT,BCL2,CCND1,CDKN1A,CRISPLD2,CXCL10,EVI2A,FDPS,FGF2,FGFR3,GRIA2,HAS2,HSD11B1,HVCN1,IL2RB,IRF1,IRF6,ITGB7,JUN,KCNIP3,KCTD1,MCF2L,MFHAS1,MST1,MYC,NDRG1,NFKBIA,NR3C1,PDE3B,PIP5K1B,PRF1,RAPGEF4,RASA3,RNF157,SDC4,SPSB1,SREBF1,STAR,TIPARP,TLR2,TMPRSS2,TRAF1,XRCC6 | 348 (21) |
| EZR | -2.30e-01 | other | NA | -4.20e-01 | 1.0e-02 | ATF4,BCL2,BCL2L1,DDIT4,MYC | NA |
| APC | 1.60e-01 | enzyme | NA | -4.20e-01 | 0.0e+00 | ADGRV1,AXIN2,CCND1,CDKN1A,COL12A1,FGF10,GLUL,HK2,JUN,KLF4,MYC,PDK4,PPARD,SGK1,TBX3,THBS1 | 448 (23) |
| INSR | 2.00e-01 | kinase | NA | -4.20e-01 | 0.0e+00 | ARL4A,ARRDC3,CCL4,CCND1,CD83,CDKN1A,CDKN2C,CORO1A,CRY1,FDPS,GADD45A,GATA6,GPAM,GRB7,HOXC6,HPGD,IDH1,IRS1,LDB2,LEP,MKNK1,MYC,NAMPT,NDRG1,NFKB2,NOG,PDK4,PLAGL1,PPARG,RGS16,SAT1,SERPINE1,SLC12A7,SOX17,SQLE,SREBF1,STAR,TEAD2,TLR2,TSC22D1 | 399 (21) |
| HSPA5 | 3.30e-01 | enzyme | NA | -4.20e-01 | 3.0e-02 | ACLY,BCL2,BCL2L1,CXCL10,GRIA2,SREBF1 | NA |
| TOB1 | -7.70e-01 | transcription regulator | NA | -4.30e-01 | 2.0e-02 | BANP,BCL2L1,CCND1,CDKN1A,GMNN,MBNL2 | NA |
| PLK1 | 2.40e-01 | kinase | NA | -4.30e-01 | 0.0e+00 | CDKN1A,CFLAR,CLSPN,DTX3L,GMNN,MYC,PYCARD,SMAD7,THBS1 | 369 (16) |
| CEBPB | 2.60e-01 | transcription regulator | NA | -4.30e-01 | 0.0e+00 | ADH1C,ADRB3,AGT,APLN,APLNR,BCL2,BCL2L1,CCL4,CCND1,CDKN1A,CDKN2C,CEBPD,CHEK2,CIRBP,CRP,CSF3,CSF3R,CXCL10,FGFR2,FHL2,FOXO3,FTL,GADD45A,HAS2,HDC,HSD11B1,HSD11B2,HUS1,IGFBP4,IKBKE,IL1RN,IRS1,IRS2,ITGAL,JUN,LEP,MRC1,MYC,NFKBIZ,NRP1,ORC2,PDK4,PLXND1,POLD1,PPARD,PPARG,RANBP1,RORA,SAT1,SERPINE1,SGK1,SLC7A1,SREBF1,STAR,TFRC,UPP1,VDR,WEE1,XRCC6 | 407 (22) |
| KL | 4.00e-02 | enzyme | NA | -4.30e-01 | 0.0e+00 | ATF4,BCL2,BCL2L1,CCND1,CDKN1A,KDR,MERTK,MITF,MYC,TYRO3,VDR | 409 (22) |
| AMH | -3.40e-01 | growth factor | NA | -4.30e-01 | 1.0e-02 | ACVR1,BTG2,CDKN1A,IRF1,STAR | 175 (12) |
| seocalcitol | NA | chemical drug | NA | -4.40e-01 | 0.0e+00 | BCL2,BCL2L1,CDKN1A,GADD45A,MST1,MYC,SGK1,TMPRSS2,VDR | 395 (22) |
| Alpha catenin | NA | group | NA | -4.40e-01 | 0.0e+00 | ADAMTS1,AXIN2,BCL2L1,BIRC3,CXCL10,ELK3,IGFBP4,IRF1,MYC,NFKBIA,NFKBIZ,RELB,SGK1,TGM2 | 361 (17) |
| bisphenol A | NA | chemical - endogenous mammalian | NA | -4.40e-01 | 0.0e+00 | BCL2,CCND1,CDKN1A,CXCL10,GABRE,KDR,LEP,MBNL2,MET,PER1,PICALM,PPARG,RBM47,RPL9,SGK1,SKIL,TGM2,THBS1 | 365 (26) |
| DYRK1A | 2.20e-01 | kinase | NA | -4.40e-01 | 0.0e+00 | CCND1,CDKN1A,IRS1,NFKB2,SERPINE1 | 423 (24) |
| RNF187 | 2.00e-02 | enzyme | NA | -4.40e-01 | 0.0e+00 | BHLHE40,BTG2,CCND1,CDKN1A,CXXC4,IRF1,JUN,KLF4,MOV10,NFKB2,PML,TP53INP1,ZFP36 | 320 (10) |
| bombesin | NA | chemical - endogenous mammalian | NA | -4.50e-01 | 0.0e+00 | MET,MYC,NR3C1,TMPRSS2,ZBTB16 | NA |
| KCNJ10 | -1.70e-01 | ion channel | NA | -4.50e-01 | 0.0e+00 | CXCL10,GADD45A,GBP5,LGALS3,Pmaip1 | NA |
| sterol | NA | chemical - endogenous mammalian | NA | -4.50e-01 | 1.0e-02 | ACLY,FDPS,GPAM,IDH1,PCYT1A | 298 (14) |
| formaldehyde | NA | chemical - endogenous mammalian | NA | -4.50e-01 | 1.0e-02 | BNIP3,HK2,JUN,NDRG1,PENK,SGK1 | 394 (20) |
| collagenase | NA | group | NA | -4.50e-01 | 1.0e-02 | CCL4,CEBPD,CXCL10,IRF1,JUN | NA |
| D-galactosamine | NA | chemical - endogenous mammalian | NA | -4.50e-01 | 2.0e-02 | BCL2,CXCL10,EDNRA,JUN,MYC,NFKBIA | NA |
| ATP2B2 | 7.00e-02 | transporter | NA | -4.50e-01 | 4.0e-02 | BATF2,BCL2,CDKN1A,GADD45A,TYK2 | NA |
| DDX17 | NA | enzyme | NA | -4.50e-01 | 1.0e-02 | CCND1,CDKN1A,JUN,MYC | 369 (11) |
| FSH | NA | complex | NA | -4.50e-01 | 0.0e+00 | ADAMTS1,APLN,AXIN2,BMPR2,BTG2,CCND1,CFLAR,CITED1,CX3CL1,DUSP9,ELL2,EPS15,FGF2,FKBP5,FOXO1,GATA6,HDAC5,HK2,HSD11B1,IGFBP4,IL1RN,IL6R,INHBB,JUN,LOX,MAP3K5,MAPK6,MYC,PENK,PHKA2,PI4K2A,PLK2,RAB27A,RGS16,SERPINE1,SGK1,SMAD7,SNAP25,STAR,TFRC,THBS1,TOB1,TP53I11,TRIB1,TYRO3,UPP1 | 357 (20) |
| apicidin | NA | chemical - endogenous non-mammalian | NA | -4.60e-01 | 1.0e-02 | CDKN1A,H6PD,ITGB7,TGM2 | NA |
| IKBKB | -1.70e-01 | kinase | NA | -4.60e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CBLB,CCL4,CCND1,CDKN1A,CEBPD,CFLAR,CX3CL1,CXCL10,FGF10,FOXO1,FOXO3,FSCN1,GADD45A,GBP2,HK2,IL1RN,IRF1,Mt1,MYC,NFKB2,NFKBIA,RELB,RGS16,SGK1,SMAD7,SMURF1,ZNF395 | 281 (13) |
| BRCA1 | -7.00e-02 | transcription regulator | NA | -4.60e-01 | 0.0e+00 | ALDH1A3,APOBEC1,BACH1,BCL2,BCL2L1,CCND1,CDKN1A,DDIT4,FHL2,FKBP5,FOXO1,FOXO3,GADD45A,H3-3A/H3-3B,HSD11B2,MYC,NR3C1,SAT1,STAT5A,TAP1,WEE1,XRCC6 | 395 (19) |
| UCHL1 | 4.80e-01 | peptidase | NA | -4.70e-01 | 0.0e+00 | BACH2,BCL2L1,CDKN1A,GABPB1,LBH,MAPK6,PI4K2B,PIK3CG,SERPINE1,STXBP4,TRIM2,UBA7 | 139 (4) |
| TRPC1 | NA | ion channel | NA | -4.70e-01 | 1.0e-02 | CCND1,CDKN1A,FOXO1,KDR,SPHK1 | 364 (21) |
| CTSB | 1.50e-01 | peptidase | NA | -4.70e-01 | 1.0e-02 | CCND1,KDR,MYC,SPHK1,XRCC6 | NA |
| docetaxel | NA | chemical drug | NA | -4.70e-01 | 3.0e-02 | BCL2,BCL2L1,CDKN1A,CHEK2,CXCL10,CXCL11,EDNRA,FGF2,KDR,THBS1,TRPC3 | NA |
| DUSP1 | 6.80e-01 | phosphatase | NA | -4.70e-01 | 0.0e+00 | AACS,BCL2,CCL4,CIDEC,CXCL10,IL1RN,IRF1,JUN,MERTK,MRC1,NAMPT,NRP1,SERPINE1,SLC15A3,STAT5A,TLR2,ZFP36 | 370 (14) |
| NTRK2 | 1.70e-01 | kinase | NA | -4.80e-01 | 0.0e+00 | CCND1,CDKN1A,CDKN2C,FGF2,KCNJ9,MYC,PYCARD,RAB3A,SERPINE1,SNAP25,THBS1 | 426 (22) |
| PELP1 | -2.00e-02 | other | NA | -4.80e-01 | 0.0e+00 | BCL2L1,CCND1,CDKN1A,COL12A1,CSF3,CXXC5,FGFR3,FMN2,IKBKE,LEP,MLPH,MRC1,MYC,NDRG1,PPARG,PRMT6,TCF7L2,TGM2 | 337 (24) |
| cholic acid | NA | chemical - endogenous mammalian | NA | -4.80e-01 | 5.0e-02 | AGT,CIRBP,CYP2B6,RAI1,SQLE,SREBF1,VIPR2 | NA |
| TNF | -5.20e-01 | cytokine | NA | -4.80e-01 | 0.0e+00 | ADCY5,ADORA1,ADRB3,AGT,AGTR1,ALDH1A3,ANKRD55,APLN,ARHGEF40,ARRDC3,ATF4,AXIN2,BCL2,BCL2L1,BHLHE40,BIRC3,BMPER,BTG1,BTG2,C1QTNF1,CA12,CCL24,CCL4,CCND1,CD38,CD83,CDC42EP2,CDKN1A,CDKN2C,CEBPD,CFLAR,CIDEC,CISH,CMKLR1,COL7A1,CRISPLD2,CRP,CRY1,CSF2RB,CSF3,CX3CL1,CX3CR1,CXCL10,CXCL11,CYLD,DBT,DDIT4,DENND2D,DUSP9,EDNRB,EGLN3,ELK3,ETV6,FADD,FDPS,FGF10,FGF2,FGFR2,FMO1,FOXO1,FSCN1,GADD45A,GADD45G,GBP2,GBP4,GNA15,GPAM,GPR88,HAS2,HAS3,HDC,HK2,HMGN3,HPGD,HSD11B1,HUS1,IGFBP4,IKBKE,IL1R2,IL1RN,IL6R,IRAK2,IRF1,IRS1,IRS2,ITGA1,ITGAL,ITGB7,JARID2,JUN,KDR,KIAA1671,KLB,KLF4,KLF6,LEP,LGALS3,LIMK1,LOX,LRIG1,LTB4R,LYVE1,Madcam1,MAFF,MAP3K4,MERTK,MET,MFHAS1,MFSD2A,MGST2,MITF,MST1,MST1R,Mt1,MYC,NAMPT,NFATC1,NFKB2,NFKBIA,NFKBIZ,NR3C1,NRARP,NRIP3,NRP1,NRROS,NUAK1,NUCB2,OAS2,P2RX5,PCYT1A,PENK,PGF,PIK3C2B,PIK3CB,PIK3CG,PILRB,PLIN4,PLK2,PML,PNPLA8,PPARD,PPARG,PTPN11,PYCARD,RANBP9,RASD1,RELB,RGS16,RGS20,RND3,RORA,RXRB,S100A10,SAT1,SDC4,SERPINE1,SGK1,SIRPA,SLC15A3,SLC7A1,SLC7A8,SMAD7,SMURF1,SPHK1,SPSB1,SQLE,SREBF1,ST3GAL6,STAC,STAR,STAT5A,TAP1,TFRC,TGM2,THBS1,TINAGL1,TLR2,TP53INP1,TPO,TRAF1,TRAF4,TRAF5,TRAF6,TRPC3,TYK2,UCK1,VDR,VIP,VIPR2,VMP1,WNT5A,ZFP36 | 445 (18) |
| USF2 | -9.00e-02 | transcription regulator | NA | -4.80e-01 | 3.0e-02 | AGT,APLN,MYC,P4HA1,SERPINE1,STAR,THBS1 | NA |
| KHDRBS1 | 1.30e-01 | transcription regulator | NA | -4.90e-01 | 1.0e-02 | BCL2L1,CCND1,ECE1,LEP | 224 (13) |
| CBL | 3.40e-01 | transcription regulator | NA | -5.00e-01 | 1.0e-02 | BCL2,CDKN1A,CFLAR,CSF2RB,EPHA4,FGFR2,LEP | NA |
| pemetrexed | NA | chemical drug | NA | -5.10e-01 | 1.0e-02 | ARRDC3,CDKN1A,DCK,MET,PLK2 | NA |
| MAP4K4 | -1.20e-01 | kinase | NA | -5.10e-01 | 1.0e-02 | ACACB,ACLY,CBLB,GLUL,H6PD,NDUFA5,PDXP,PI4K2B,PPARG,SREBF1,UCK1 | NA |
| KMT2A | -1.30e-01 | transcription regulator | NA | -5.10e-01 | 0.0e+00 | ADRA1A,BAHCC1,BCL2,CDKN1A,CDKN2C,HOXC6,HOXD3,IGFBP4,KLF6,MEIS2,MYC,PROM1,SATB2,TRIB1,ZFAND2A | 387 (18) |
| infliximab | NA | biologic drug | NA | -5.10e-01 | 0.0e+00 | ADAM19,DDIT4,NAMPT,NFKB2,NFKBIA,PRF1,SLC7A5,SPHK1,TRAF1,WEE1 | 386 (16) |
| ERBB4 | -2.30e-01 | kinase | NA | -5.10e-01 | 1.0e-02 | ADAM19,BTG2,CCND1,CDKN1A,GADD45A,IGFBP4,JUN,MYC,RASA3,THBS1 | 433 (21) |
| LIPE | 4.40e-01 | enzyme | NA | -5.10e-01 | 1.0e-02 | ADH1C,BCL2,FKBP5,H3-3A/H3-3B,MRC1,PDK4,PER1,PHKG1,PPARG,SDC4,SMAD7,SREBF1,STAR | NA |
| THRB | -2.80e-01 | ligand-dependent nuclear receptor | NA | -5.10e-01 | 4.0e-02 | BIRC3,BTG2,CCND1,CXCL10,FDPS,FGFR3,FZD8,GJA5,JUN,MET,MYC,Oasl2,PDK4,PENK,PER1,PPARG,PROM1,SERPINE1,SREBF1,TLR2 | NA |
| quercetin | NA | chemical drug | NA | -5.10e-01 | 1.0e-02 | BCL2,BCL2L1,BHLHE40,BIRC3,CDKN1A,CXCL10,EPHX2,IRS2,ITGAL,JUN,KLF4,LEP,MRGPRF,MYC,NR1D1,NT5E,SMAD7,STAR,WNT5A | 404 (23) |
| PPP2CA | 4.80e-01 | phosphatase | NA | -5.10e-01 | 0.0e+00 | BCL2,CCND1,CDKN1A,CXCL10,FOXO3,IL2RB,IRF1,ITGAL,MYC,NT5E,UPP1 | 393 (25) |
| alvocidib | NA | chemical drug | NA | -5.20e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,CFLAR,XRCC6 | 413 (23) |
| salinosporamide A | NA | chemical drug | NA | -5.20e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CFLAR,MYC,TRAF1 | 284 (11) |
| IFIH1 | 1.70e-01 | enzyme | NA | -5.20e-01 | 0.0e+00 | CCL4,CISH,CXCL10,IFI44L,NFKBIA,OAS2,PRF1,RND3 | 367 (19) |
| MAP2K1 | 1.90e-01 | kinase | NA | -5.20e-01 | 0.0e+00 | AXIN2,BCL2,BCL2L1,BIRC3,CCL4,CCND1,CDKN1A,CFLAR,CRP,ERRFI1,FGF2,HDC,IRS1,JUN,LEP,LGALS3,MITF,MYC,NFKBIA,SIRPA,STAR,TGM2,THBS1,TRIB1 | 300 (19) |
| tert-butyl-hydroquinone | NA | chemical reagent | NA | -5.30e-01 | 2.0e-02 | BACH1,BCL2,FTL,GADD45A,JUN,PPARG,SERPINE1,WNT5A,ZNF184 | NA |
| NR1H3 | -3.80e-01 | ligand-dependent nuclear receptor | NA | -5.30e-01 | 0.0e+00 | ADRB3,BCL2L1,CCL24,CCL4,CD38,CDKN1A,CHEK2,CLSPN,CRP,CSF3,CX3CL1,CX3CR1,CXCL10,FDPS,FGL2,GBP4,GPAM,HSD11B1,IL1RN,ITGAL,MERTK,Mt1,NFKBIA,NOD1,PPARG,SLC16A10,SREBF1,STAR,TAP1,TRIB1 | 440 (21) |
| HOTAIR | NA | other | NA | -5.30e-01 | 0.0e+00 | ABL2,ATG7,CDKN1A,CEBPD,MPZL2,MYC,NFKBIA,PPARG,TEAD1 | 422 (25) |
| glutathione | NA | chemical - endogenous mammalian | NA | -5.40e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CDKN1A,FOXO3,GNL3,MET,MYC,NDRG1,SERPINE1 | 382 (22) |
| SHH | 1.20e-01 | peptidase | NA | -5.40e-01 | 1.0e-02 | ADAMTS1,AMD1,BCL2,CCND1,FGF10,HK2,HSD11B2,IMPDH2,LMX1A,MET,MYC,NOG,PGF,PPARG,SERPINE1,SREBF1,WNT5A | 425 (25) |
| miR-30c-5p (and other miRNAs w/seed GUAAACA) | NA | mature microRNA | NA | -5.40e-01 | 0.0e+00 | ACVR1,ADAMTS15,CCND1,CHD1,IDH1,IFRD1,IRS2,JUN,MET,MYC,MYO10,NT5E,PPARG,SLC7A1,STX1A,WNT5A | NA |
| alitretinoin | NA | chemical drug | NA | -5.50e-01 | 0.0e+00 | ACACB,BCL2,BCL2L1,CCL24,CCND1,CD38,CD83,CDKN1A,CXCL10,CXCL11,CYP2B6,IL2RB,IRF1,PPARG,SREBF1,UBA7 | 419 (22) |
| NR0B2 | -1.40e-01 | ligand-dependent nuclear receptor | NA | -5.50e-01 | 0.0e+00 | ACLY,AGT,CARD11,CDKN1A,CIDEC,CXCL10,CYP2B6,HDC,IL1RN,PDK4,PIK3CG,PPARG,SERPINE1,SREBF1,TLR2 | 329 (23) |
| NCOA5 | -3.90e-01 | other | NA | -5.50e-01 | 0.0e+00 | ARRDC3,CDKN1A,CIDEC,GADD45G,MYBL1,MYC,PLAGL1,SLC25A30 | NA |
| MYCN | -5.80e-01 | transcription regulator | NA | -5.50e-01 | 1.0e-02 | ABCA6,ADAMTS1,APEX1,BCL2L1,CCND1,CCNT1,CDKN1A,EIF4A1,FGFR2,GATA6,HDAC5,HK2,JARID2,MITF,NDRG1,PROM1,PTPRO,RPL9,S100A10,SERPINE1,SLC16A1,SOX17,TGM2,TMPRSS2 | NA |
| NF1 | 0.00e+00 | other | NA | -5.60e-01 | 0.0e+00 | AXIN2,BCL2L1,CBS/LOC102724560,CCND1,FGF2,MYC | 354 (19) |
| SIRT2 | -6.00e-02 | transcription regulator | NA | -5.60e-01 | 0.0e+00 | AACS,ACLY,CXCL10,Oasl2,SQLE | 166 (7) |
| CYP2J2 | 1.10e-01 | enzyme | NA | -5.60e-01 | 0.0e+00 | BCL2,BCL2L1,NFKBIA,PIK3CG,PPARG | 380 (24) |
| RUVBL1 | -3.00e-02 | transcription regulator | NA | -5.60e-01 | 5.0e-02 | AXIN2,CCNT1,KIFC2,NUCKS1,POMK | NA |
| PITX2 | 1.00e-01 | transcription regulator | NA | -5.60e-01 | 1.0e-02 | ADH1C,CCND1,DACT2,FMO2,FOXO1,GADD45A,GFOD2,HPGD,IRF6,KCTD1,MYC,TBX3,WNT5A | NA |
| GATA1 | NA | transcription regulator | NA | -5.60e-01 | 0.0e+00 | ALOX12,ANK1,ARHGAP4,BACH2,BCL2,BCL2L1,BTG2,CCND1,CDKN1A,CDKN2C,CIR1,IL6R,INHBB,KDR,MAP3K5,MGST2,MITF,MYC,NFIL3,NRARP,PLEK,PLXNA1,PLXNA2,POLD1,PSTPIP2,RANBP1,SLC19A1,SLC3A2,SSBP3,ST3GAL6,STAT5A,TFEB,TFRC,TGM2,USP16,VDR | 302 (20) |
| anisomycin | NA | chemical - endogenous non-mammalian | NA | -5.60e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CDKN1A,CFLAR,IRF1,IRS1,JUN,SERPINE1,SKIL,TCF7L2,VIP | 359 (21) |
| TNFRSF8 | -5.20e-01 | transmembrane receptor | NA | -5.60e-01 | 0.0e+00 | CCL4,CDKN1A,GBP2,MYC,NFKB2,PRF1,RELB,TRAF1 | 327 (18) |
| OVOL2 | -2.30e-01 | transcription regulator | NA | -5.60e-01 | 5.0e-02 | ARHGAP20,CDKN1A,CDKN2C,EPHA4,HK2 | NA |
| tamoxifen | NA | chemical drug | NA | -5.70e-01 | 0.0e+00 | ADORA1,ATF4,BCL2,BCL2L1,CCND1,CDKN1A,CEBPD,CFLAR,CYP2B6,EPHA4,FADD,FHL2,HAS2,IGFBP4,IL1RN,IRF1,IRS1,JUN,LGALS3,MAFF,MET,MYC,PPARG,SCN1B,SLC7A5,SMAD7,SREBF1,VDR | 420 (22) |
| TO-901317 | NA | chemical reagent | NA | -5.70e-01 | 0.0e+00 | ABCA5,ACLY,ADH1C,BCL2L1,CCL24,CCND1,CRP,FDPS,FMO1,FMO5,GPAM,HK2,HSD11B1,IGFBP4,LGALS3,Mt1,NFKBIA,NR1D1,PPARG,RDH16,SREBF1,STAR,TGM2 | 426 (23) |
| miR-29b-3p (and other miRNAs w/seed AGCACCA) | NA | mature microRNA | NA | -5.70e-01 | 3.0e-02 | ADAMTS15,AXIN2,CCND1,FGFR4,FRAT2,HMGN3,KLF4,LEP,WBP11 | NA |
| STAT5B | -3.00e-01 | transcription regulator | NA | -5.80e-01 | 0.0e+00 | ADGRV1,BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,CFLAR,CIRBP,CISH,CYP2B6,FMN2,FMO2,GADD45A,GLUL,H2-T22,IL2RB,IRF1,JUN,LEP,MYC,NRP2,NT5E,NUCB2,Oasl2,PCSK5,PDK4,PROM1,RASD1,STAR,STAT5A,SYBU,TGM2,TLR2,TMEM45B,TRAF1,TRAF4,TULP2,UBA7,ZFP36 | 398 (20) |
| PER1 | 7.10e-01 | transcription regulator | NA | -5.80e-01 | 0.0e+00 | CCND1,CRY1,DBP,LEP,PER1,PER3,SLC12A3 | 243 (16) |
| TMPRSS2-ERG | NA | fusion gene/product | NA | -5.80e-01 | 1.0e-02 | CBX2,DDIT4,DYSF,FOXP2,FSCN1,HCAR1,LURAP1L,MYC,PLXNA2,PPARG,THBS1,TLR2 | NA |
| TICAM1 | NA | other | NA | -5.80e-01 | 0.0e+00 | AGTR1,CCL4,CD38,CEBPD,CFLAR,CXCL10,CXCL11,EDNRB,Ifi47,Igtp,IKBKE,IRF1,Irgm1,MAFF,MET,NFKB2,NFKBIA,NFKBIZ,PSTPIP2,RELB,SAMHD1,SERPINE1,TLR2,TSC22D1 | 361 (14) |
| Akt | NA | group | NA | -5.80e-01 | 0.0e+00 | AMOT,ATF4,ATG7,BCL2,BCL2L1,BHLHE40,BTG2,CCND1,CDKN1A,CFLAR,CXCL10,EPAS1,FKBP5,FOXO1,FOXO3,GALNT10,HIF3A,HIGD1A,HK2,HPGD,IL2RB,JUN,LEP,MYC,NDRG1,NFATC1,NFIL3,NFKBIA,NRP2,NT5E,PDK4,PPARD,PPARG,RASD1,RPL9,SEMA6D,SERPINE1,SGK1,SLC7A5,ST3GAL6,THBS1,TIPARP,TLR2 | 425 (21) |
| RUNX3 | -3.70e-01 | transcription regulator | NA | -5.80e-01 | 0.0e+00 | CCND1,CDKN1A,CFLAR,COL12A1,FGF2,FMN2,ITGAL,LILRB3,LOX,MYC,NUAK1,REEP1,TEAD1 | 345 (22) |
| MAPT | 7.00e-02 | other | NA | -5.90e-01 | 1.0e-02 | ACLY,APOBEC1,CALML3,CCL4,CCND1,CD22,CDKN1A,CORO1A,COX5A,CXCL10,ENDOU,FGFR3,FGR,GBP2,GBP4,GBP5,HSPB8,Igtp,IL1RN,Irgm1,ITGA1,JUN,MTHFD1L,NDUFA5,NFKB2,Oasl2,PENK,PLIN4,PRDX6,ROCK2,SERPINE1,SNAP25,STX1B,TAP1,THBS1,TLR2,TOMM70,TPPP | 394 (18) |
| WT1 | -3.80e-01 | transcription regulator | NA | -5.90e-01 | 0.0e+00 | BCL2,BCL2L1,BTG2,CBS/LOC102724560,CCL24,CCND1,CDKN1A,CDKN2C,CIRBP,CX3CL1,CXCL10,FDPS,IL1RN,IL2RB,KLF4,LGALS3,MED13,MYC,NDRG1,SERPINE1,SLC6A6,SQLE,THBS1,TSC22D1,VDR | 416 (27) |
| TSC1 | 4.00e-02 | other | NA | -5.90e-01 | 1.0e-02 | ACACB,AXIN2,BCL2,DLG3,FOXO1,FOXO3,GLUL,IRS1,IRS2,SREBF1 | NA |
| CTNNB1 | 0.00e+00 | transcription regulator | NA | -5.90e-01 | 0.0e+00 | ACLY,ADGRG2,ADGRV1,Akr1c14,ALDH1A3,AMIGO1,ARL4A,AXIN2,BCL2,BCL2L1,BCL9,BCS1L,BHLHE40,CCL4,CCND1,CDKN1A,CHEK2,CIDEC,COX5A,CSF3,CX3CL1,CXCL10,CXXC4,DIXDC1,FGD4,GADD45G,GLUL,GPAM,GRAMD4,Gulo,HK2,IMPDH2,INHBB,IRS1,ITGA1,ITGAL,ITGB7,ITSN1,JUN,KDR,LBH,LGALS3,MAP3K5,MITF,MMP15,MPZL2,MYC,NFATC1,NFKB2,NRP2,OGG1,PIP5K1B,PML,PPARD,PPARG,PPP1R13B,PROM1,RAB3A,RASSF4,RELB,RPL9,RPS18,SEMA6A,SERPINE1,SGK1,SH2B2,SMAD7,SOX17,SRFBP1,STAT5A,TCF3,TCF7L2,TEAD2,TELO2,TGM2,TRAF1,TRAF4,TSC22D1,ZNF778 | 387 (19) |
| miR-7a-5p (and other miRNAs w/seed GGAAGAC) | NA | mature microRNA | NA | -5.90e-01 | 1.0e-02 | IRS1,IRS2,KLF4,MKNK1,SLC3A2 | NA |
| CXCL8 | NA | cytokine | NA | -6.00e-01 | 0.0e+00 | BCL2,BCL2L1,CFLAR,COL12A1,IFRD1,ITGA1,ITGAL,KLF4,LGALS3,MYO1E,NFKBIA,NR3C1,PLD2,SREBF1,STAR,ZFP36 | 440 (18) |
| plumbagin | NA | chemical drug | NA | -6.00e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CFLAR | 348 (19) |
| CTBP1 | -6.00e-02 | enzyme | NA | -6.00e-01 | 2.0e-02 | CDKN1A,FDPS,FKBP5,FSCN1,THBS1,VDR | NA |
| SMARCA4 | 3.00e-02 | transcription regulator | NA | -6.00e-01 | 0.0e+00 | ACE2,AGT,ALDH1A3,AXIN2,BCL2,CCND1,CDKN1A,CHEK2,COL7A1,DYSF,EDNRA,EFNB1,EPHA4,FADS3,FGFR2,FHL2,FKBP5,FMO2,GADD45A,GADD45G,HPGD,IGFBP4,IRF1,IRF6,JUN,KDR,KIFC3,LGALS3,LOX,LRAT,MAFF,MC5R,Mt1,MYC,NFKB2,NFKBIZ,NRIP3,NRP1,NRP2,NT5E,PER3,PGM2L1,PIDD1,Pmaip1,PPARG,RAB27A,SERPINE1,SOX17,SPHK1,TAP1,TCF7L2,TLR2 | 382 (21) |
| vismodegib | NA | chemical drug | NA | -6.10e-01 | 0.0e+00 | BCL2,CSF3,DCK,GATA6,KLF4,LGALS3,NT5C1A,PPARG | 328 (18) |
| GATA2 | -9.00e-02 | transcription regulator | NA | -6.20e-01 | 1.0e-02 | CCND1,CDKN1A,CX3CL1,CXCL10,DENND2A,EDNRA,ETV6,FGD4,GBP2,GCSAM,HDC,IL2RB,KDR,KLF4,LTB4R,MRGPRX3,MYC,NFIL3,PIK3CG,PLK2,PPARG,SAMD5,TEAD1,TFRC,TGM2,THBS1,TMPRSS2,TPH1,TRIM10 | NA |
| APLN | -1.00e+00 | other | NA | -6.20e-01 | 1.0e-02 | ACE2,BCL2,FSCN1,IRS1,KDR,MYC,PRND,S100A10,TMEM26 | NA |
| NF2 | 8.00e-02 | other | NA | -6.30e-01 | 1.0e-02 | AMOT,CCND1,CDKN1A,GLUL,MYC,TFRC | 399 (25) |
| LDL | NA | complex | NA | -6.30e-01 | 0.0e+00 | BCL2,BCL2L1,CBS/LOC102724560,CCL4,CCND1,CDKN1A,CFLAR,CX3CR1,CXCL10,CXCL11,ECE1,EDNRB,FDPS,GJA5,HAS2,HAS3,IGFBP4,IL1RN,JUN,NAMPT,NRP1,PPARG,RANBP1,RND3,SERPINE1,SIPA1,SPHK1,SREBF1,STAR,TLR2,TRAF6 | 429 (20) |
| topotecan | NA | chemical drug | NA | -6.30e-01 | 0.0e+00 | ARHGAP42,ASAP3,ATF4,BIRC3,BTG1,CCL4,CD83,CDKN1A,CEBPD,CFLAR,CHD1,CREB3L2,CSF3,CXCL10,DCK,EFNB1,FGFR3,IRF1,IRS1,JAK3,JUN,MBNL2,MED13L,MGST2,MYC,NCKAP5,NFKB2,NFKBIA,PHKG1,PIDD1,PLK2,RDH13,RELB,SLC7A5,TRAF6,ZFP36 | 353 (17) |
| phenethyl isothiocyanate | NA | chemical drug | NA | -6.30e-01 | 4.0e-02 | BCL2,BCL2L1,CCND1,IDH1,KDR,MAPK6,Ppp1r15a,RLIM,ROCK2 | NA |
| SKIC2 | NA | enzyme | NA | -6.30e-01 | 0.0e+00 | BHLHE40,DDIT4,EGLN3,HK2,MTHFD2,P4HA1,SLC6A6,SLC7A5,SQLE,TFRC | NA |
| SAMSN1 | -3.00e-01 | other | NA | -6.30e-01 | 1.0e-02 | CCL4,CXCL10,FGL2,HDC,IRF1,MERTK,NFKBIZ,PML,STAT5A,TSC22D1 | 316 (13) |
| IL21 | NA | cytokine | NA | -6.40e-01 | 0.0e+00 | BCL2,BCL2L1,CCL24,CCL4,CD244,CD38,CDKN1A,CXCL10,FGL2,GBP5,Igtp,IL2RB,Irgm1,OAS2,PRF1,RORA,SGK1,TAP1 | 363 (16) |
| IRF8 | -2.70e-01 | transcription regulator | NA | -6.40e-01 | 0.0e+00 | BCL2,BCL2L1,CD83,CDKN1A,CSF3R,CXCL10,ETV6,GNA15,IFI44L,IL1RN,KLF4,KLF6,MET,MYC,NFATC1,OAS2,Oasl2,Pmaip1,PML,STX2 | 350 (16) |
| DNMT3B | -3.00e-01 | enzyme | NA | -6.40e-01 | 1.0e-02 | ADCY5,ADORA1,AGTR1,CDKN1A,EDNRA,ESRP2,FGF2,KDR,LONRF1,MYC,MYH7B,PIK3C2B,RCC1,RGS16,TRPC3 | NA |
| sodium bisulfide | NA | chemical reagent | NA | -6.40e-01 | 2.0e-02 | AGT,AGTR1,BCL2,CDKN1A,CX3CL1,CX3CR1,Pmaip1 | NA |
| ELAVL1 | -6.00e-02 | other | NA | -6.50e-01 | 2.0e-02 | BCL2L1,CD83,CDKN1A,F830016B08Rik,IL1R2,IRF1,Irgm1,MYC,NFKBIA,OAS2,PROM1,SAT1,TLR2,TP53INP1,TRIOBP,WEE1,WNT5A,ZFP36 | NA |
| garcinol | NA | chemical - endogenous non-mammalian | NA | -6.50e-01 | 4.0e-02 | BCL2L1,BFAR,BRPF1,PML,RELB,TCF7L2,ZFP28,ZFP36 | NA |
| IL27 | 2.30e-01 | cytokine | NA | -6.50e-01 | 0.0e+00 | CCL4,CD38,CEBPD,CFLAR,CX3CL1,CXCL10,CXCL11,GADD45G,GBP2,HPGD,IL1RN,IRF1,MRC1,MYC,NFATC1,NR3C1,TAP1 | 398 (16) |
| PROCR | 1.20e-01 | other | NA | -6.50e-01 | 1.0e-02 | CCND1,GBP2,GBP4,MYC,ROCK2 | 415 (23) |
| ZNF503 | -2.80e-01 | other | NA | -6.50e-01 | 1.0e-02 | FOXO1,LRAT,MERTK,PENK,PLXND1 | NA |
| JAK inhibitor I | NA | chemical drug | NA | -6.50e-01 | 1.0e-02 | BCL2L1,CD38,CXCL10,CXCL11,SGK1 | 327 (17) |
| miR-503-5p (miRNAs w/seed AGCAGCG) | NA | mature microRNA | NA | -6.50e-01 | 1.0e-02 | CCND1,CDKN1A,FGF2,WEE1 | NA |
| POR | -3.40e-01 | enzyme | NA | -6.50e-01 | 1.0e-02 | AASDH,ACLY,Akr1c14,CYP2B6,FDPS,FLVCR2,GBP2,KDR,MAP3K6,Mt1,PDK4,PNPLA7,PPARG,SDC4,SQLE,TMEM267 | NA |
| sertraline | NA | chemical drug | NA | -6.60e-01 | 0.0e+00 | ATF4,BCL2,DDIT4,NR3C1,PDE4A,SLC7A5,TPH1 | 184 (7) |
| Hdac | NA | group | NA | -6.60e-01 | 0.0e+00 | ADAMTS1,AGTR1,BCL2,BCL2L1,CCND1,CDKN1A,CX3CL1,EDNRA,EDNRB,HPGD,IL6R,JUN,KLF6,MYC,NRP1,PGF,STX1A,TBX3 | 404 (19) |
| PRKCI | 6.00e-02 | kinase | NA | -6.60e-01 | 3.0e-02 | CCND1,CXCL10,HK2,IRF1,SREBF1 | NA |
| CSF2 | -1.00e-02 | cytokine | NA | -6.60e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CARD11,CCL4,CCND1,CD180,CD38,CD83,CD8A,CDKN1A,CDKN2C,CISH,CSF2RB,CSF3,CX3CR1,CXCL10,FANCA,HAS2,HDC,HK2,IFRD1,IL1RN,JUN,KCTD11,LEP,MET,MFSD2A,MKNK1,MRC1,MYC,NFATC1,NFKB2,NFKBIA,NRP1,PIK3CG,POLD1,PPARG,RBM3,RELB,SGK1,SPHK1,SREBF1,TGM2,THBS1,TLR2,UPP1,VDR,ZFP36 | 404 (17) |
| CPT1B | -2.00e-01 | enzyme | NA | -6.60e-01 | 0.0e+00 | ACACB,BRAF,CBLB,COX5A,CYS1,EGLN3,EPAS1,FOXO1,GPAM,HK2,IRS1,IRS2,LEP,MKNK1,NDUFA5,NFKBIA,PDE3B,PDK4,PHKA2,PHKG1,PIK3CB,PIK3CG,SH2B2,SREBF1 | 128 (7) |
| tosylphenylalanyl chloromethyl ketone | NA | chemical - protease inhibitor | NA | -6.60e-01 | 0.0e+00 | BCL2,BIRC3,EPHX2,MYC,PRF1,SMAD7 | 351 (18) |
| telmisartan | NA | chemical drug | NA | -6.60e-01 | 0.0e+00 | ACE2,AGT,AGTR1,APLN,APLNR,BCL2,LEP,MAS1,MRC1,PPARD,PPARG,TRPC3 | 403 (22) |
| SP600125 | NA | chemical drug | NA | -6.70e-01 | 0.0e+00 | BCL2,BCL2L1,BTG2,CCL4,CCND1,CD83,CDKN1A,CIDEC,COL7A1,CREB3L2,CSF3,CXCL10,DDIT4,FLRT3,FOXO1,GADD45A,GBP2,Gulo,IL1RN,IL6R,IRS1,JUN,MTHFD2,MTHFR,NFKBIA,NR3C2,PER1,PLK2,PPARG,PROM1,SERPINE1,SOX17,SPHK1,SREBF1,TCF7L2,THBS1,VDR,ZFP36 | 438 (18) |
| estrogen receptor | NA | group | NA | -6.70e-01 | 0.0e+00 | BCL2,CA12,CCND1,COL12A1,COL7A1,CYP2B6,FGFR2,FGFR3,FGFR4,GAL,IRS1,JUN,MMP15,MYC,NT5E,PCDH20,PDK4,PPARG,SAT1,SERPINE1,TGM2,TMEFF1,WNT5A | 487 (20) |
| CCL2 | -4.20e-01 | cytokine | NA | -6.70e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CEBPD,CFLAR,CXCL10,EGLN3,HDC,ITGA1,ITGAL,KLF4,PPARG,SERPINE1 | 427 (18) |
| miR-92a-3p (and other miRNAs w/seed AUUGCAC) | NA | mature microRNA | NA | -6.70e-01 | 0.0e+00 | BMPR2,CCND1,CDKN1A,CDKN2C,EDNRB,KLF4,TBX3,TRAF4 | 267 (7) |
| NCOA2 | -2.80e-01 | transcription regulator | NA | -6.70e-01 | 0.0e+00 | ADORA1,CCL4,CCND1,CDKN1A,CXCL10,CYP2B6,GBP5,GPR34,HSD11B1,IRF1,KLF4,NFKBIA,NR1D1,PPARG,RAI1,RORA,SREBF1,STAR,TCF3,VDR | 359 (24) |
| DPP4 | -5.00e-02 | peptidase | NA | -6.80e-01 | 1.0e-02 | CSF3,CXCL10,FGF2,IL1RN,SREBF1,THBS1 | NA |
| CSF3 | 2.68e+00 | cytokine | NA | -6.80e-01 | 0.0e+00 | ADCY5,AGTR1,BCL2,BCL2L1,BIRC3,CD300LF,CEBPD,CISH,CSF3R,CX3CR1,GADD45A,GADD45G,HDC,IL1RN,JAK3,JUN,MET,MYC,NFATC1,NFIL3,PPARG,Prrt1,RAB27A,TFRC,TLR2 | 435 (19) |
| homocysteine | NA | chemical - endogenous mammalian | NA | -6.80e-01 | 0.0e+00 | ACLY,ATF4,BCL2,BCL2L1,CCND1,CDKN1A,CXCL10,FDPS,FGF2,GADD45A,LEP,MTHFR,NDRG1,PGF,Pmaip1,SREBF1 | 375 (22) |
| HBEGF | 3.80e-01 | growth factor | NA | -6.80e-01 | 0.0e+00 | BCL2,BHLHE40,CCND1,FGF2,HK2,NFKBIZ,NRP1,PDK4 | 320 (17) |
| EXT1 | -3.00e-01 | enzyme | NA | -6.90e-01 | 0.0e+00 | ACACB,CCND1,CEBPD,MYC,PPARG,SREBF1 | 378 (19) |
| CXCR3 | -4.70e-01 | G-protein coupled receptor | NA | -6.90e-01 | 4.0e-02 | BCL2,BCL2L1,CXCL10,PRF1 | NA |
| PRKAR2B | 3.30e-01 | kinase | NA | -6.90e-01 | 3.0e-02 | BIRC3,LEP,PPARG,TPO | NA |
| camptothecin | NA | chemical drug | NA | -6.90e-01 | 0.0e+00 | APPBP2,ARL4A,BCL2,BCL2L1,BFAR,BIRC3,BTG2,CCND1,CD22,CD300C,CD83,CDC42EP2,CDKN1A,CFLAR,FADD,FGL2,FOXO1,FSCN1,GADD45A,GADD45G,GBP2,H3-3A/H3-3B,HSPB8,HUS1,IMPA2,IRF1,ITSN1,JUN,LGALS3,LIMK1,MAFF,MBNL2,MED13L,MERTK,Mt1,MYC,MYO10,NFKB2,NFKBIA,NR3C1,NRP1,NUCKS1,PIDD1,PIK3C2B,PIK3CG,PLD2,PSTPIP1,PYCARD,SAT1,SDC4,SERPINE1,SIPA1,SKIL,TAP1,TFRC,TLR2,TNK2,TOB1,TP53I11,TP53INP1,TRAF1,TRAF4,TRAF5,TRIB1,TYK2,UTP3 | 341 (13) |
| N6AMT1 | 7.00e-01 | enzyme | NA | -6.90e-01 | 0.0e+00 | BCL2,BTG1,CC2D2A,CDKN1A,DTL,FAM171A1,FGFR4,GRB7,IMPDH2,IRS1,LRIG1,NOD1,PDE3B,PICALM,POLD1,PTPRO,RASA3,RASSF4,TEAD2,VDR,ZBTB12,ZNF566 | NA |
| AGN194204 | NA | chemical drug | NA | -6.90e-01 | 0.0e+00 | ADAM19,CCL4,CDKN1A,CDKN2C,FDPS,GADD45A,GBP2,HK2,Ifi47,Igtp,IL1R2,IL2RB,IRF1,IRS2,ITGB7,KLF6,MITF,MYC,PDK4,PENK,PLIN4,PPARG,SEMA4B,SLC3A2,TAP1,TRAF4,ZNF423 | 368 (18) |
| N-acetyl-L-cysteine | NA | chemical drug | NA | -6.90e-01 | 0.0e+00 | ATF4,BACH1,BCL2,BCL2L1,BIRC3,BNIP3,CCND1,CDKN1A,CFLAR,CXCL10,DDIT4,FGF2,FOXO3,GNL3,HDC,HK2,JUN,LTB4R,MRC1,MYC,NFATC1,NFKBIA,NFKBIZ,PYCARD,SERPINE1,SLC16A1 | 348 (17) |
| octreotide | NA | biologic drug | NA | -6.90e-01 | 1.0e-02 | BMPR2,CDKN1A,PLAGL1,PPARG,SMAD7 | 151 (7) |
| PLIN5 | 5.10e-01 | other | NA | -6.90e-01 | 3.0e-02 | ATF4,MAFK,PDK4,PPARG,SREBF1 | NA |
| 3-deazaneplanocin | NA | chemical drug | NA | -6.90e-01 | 3.0e-02 | BCL2L1,CDKN1A,FOXO3,KLF6,MYC,SELENOS,TRIM14 | NA |
| miR-17-5p (and other miRNAs w/seed AAAGUGC) | NA | mature microRNA | NA | -7.00e-01 | 2.0e-02 | ALDH1A3,ARID4B,BCL2,BMPR2,C1QTNF1,CCND1,CDKN1A,CDKN2C,IRAK2,PPARG | NA |
| TGFBR2 | 6.00e-02 | kinase | NA | -7.00e-01 | 0.0e+00 | ALOX12,ATF4,BCL2,BHLHE40,CCL4,CCND1,CD83,CDKN1A,CITED1,CRISPLD2,CX3CR1,DDIT4,EPAS1,FFAR4,FGF2,FKBP5,GADD45G,GAL,HDC,HK2,HPGD,HSD11B1,IL1R2,IL2RB,JAK3,JUN,KCNH1,KCNJ8,KDR,LRIG1,LTB4R,MFSD2A,MIF4GD,MRC1,NFIL3,NFKBIA,NFKBIZ,NRP1,NT5E,PIK3C2B,PLAGL1,PPARG,SERPINE1,SKIL,Slc26a10,SLC7A5,SMAD7,SPAG1,THBS1,TMPRSS2,UPP1 | 404 (20) |
| xanthohumol | NA | chemical drug | NA | -7.10e-01 | 0.0e+00 | BCL2L1,BIRC3,CCND1,GAB2,MYC,NFATC1,SREBF1,TRAF6 | 315 (19) |
| SAHM1 | NA | chemical reagent | NA | -7.10e-01 | 0.0e+00 | BHLHE40,BNIP3,DDIT4,HK2,MYC,P4HA1,PPARG,ZBED3 | NA |
| CX3CL1 | -7.10e-01 | cytokine | NA | -7.10e-01 | 1.0e-02 | ADAMTS1,ASPA,ATF4,BCL2L1,CCND1,CX3CL1,CX3CR1,EFNB1,FGF2,MEIS2,PPARG,PROM1,SNAP25,SPHK1 | 427 (22) |
| geldanamycin | NA | chemical drug | NA | -7.10e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CCNT1,CDKN2C,CEBPD,CFLAR,CUL5,FADD,FKBP5,HAP1,IRF1,IRS1,IRS2,JUN,LBH,MET,MYC,NR3C1,OPTC,PRIMA1,SLC16A10,TAP1,TOMM70,TPPP,WEE1 | 423 (21) |
| Tlr | NA | group | NA | -7.10e-01 | 1.0e-02 | CCL4,CD83,CISH,CXCL10,GPR34,IRF1,NFKBIA,RGS16,RGS20,SPHK1,WNT5A | NA |
| IFN alpha/beta | NA | group | NA | -7.10e-01 | 0.0e+00 | CCL24,CD83,CX3CL1,CXCL10,FGL2,IRF1,Irgm1,MRC1,Pmaip1,TLR2 | 327 (16) |
| silibinin | NA | chemical drug | NA | -7.10e-01 | 0.0e+00 | CCND1,CD38,CDKN1A,HK2,KLF4,MYC,NFATC1,NFKBIA,PROM1 | 413 (23) |
| MRTFB | NA | transcription regulator | NA | -7.20e-01 | 0.0e+00 | ADAMTS1,BCL2L1,EDNRA,ETV6,GADD45A,HPGD,MAFK,MGST2,NFKBIZ,NUAK1,PTPRO,SAMD5,SERPINE1,SGK1,SYNPO2,THBS1,WNT5A | 180 (7) |
| CIRBP | 6.30e-01 | translation regulator | NA | -7.20e-01 | 3.0e-02 | AXIN2,CCND1,MYC,RNF43 | NA |
| RUNX2 | -3.60e-01 | transcription regulator | NA | -7.20e-01 | 2.0e-02 | AXIN2,BCL2,CCND1,CDKN1A,CEBPD,FGFR2,ITGAL,LEP,LGALS3,PIK3CB,SERPINE1 | NA |
| BAG1 | 4.60e-01 | other | NA | -7.30e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CDKN1A,FKBP5,GADD45A,JUN,NR3C1,RAB27A | 423 (22) |
| CREBZF | 1.50e-01 | transcription regulator | NA | -7.30e-01 | 1.0e-02 | ATF4,EDEM1,PDK4,SREBF1 | 161 (7) |
| IGFBP2 | 4.00e-02 | other | NA | -7.30e-01 | 3.0e-02 | BCL2L1,CCND1,EPHA4,IGFBP4,MYC,PTPRB | NA |
| semaxinib | NA | chemical drug | NA | -7.40e-01 | 0.0e+00 | CARD11,CD8A,CMKLR1,CSF2RB,CX3CR1,CXCL10,CXCL11,EPHX2,FOXO1,GDF11,IL1R2,IL2RB,KDR,NFKBIA,SEMA6B,SERPINE1,TFEB,THBS1 | 453 (23) |
| n-3 fatty acids | NA | chemical drug | NA | -7.50e-01 | 2.0e-02 | CBS/LOC102724560,IRS1,IRS2,MTHFR,PPARG,SREBF1 | NA |
| IREB2 | 4.20e-01 | translation regulator | NA | -7.50e-01 | 2.0e-02 | EPAS1,FTL,HK2,TFRC | NA |
| vitamin A | NA | chemical - endogenous mammalian | NA | -7.50e-01 | 1.0e-02 | CDKN1A,KCNG1,LEP,LRAT,RXRB | NA |
| budesonide | NA | chemical drug | NA | -7.60e-01 | 0.0e+00 | ALOX12,ARHGAP10,BNIP3,BRAF,CDKN1A,CSF3,CXCL10,ENDOU,GNA15,GPT2,HDC,IL1RN,INPP4B,JUN,LDB2,LOX,MEGF9,MTHFD1L,NAMPT,NR3C1,PCSK5,PI4K2A,RASGEF1B,SAMD5,TAX1BP1,TIPARP,TLR2,WNT5A | 396 (15) |
| GRB10 | 2.60e-01 | other | NA | -7.60e-01 | 0.0e+00 | IRS1,KDR,MRC1,TGM2 | NA |
| PNN | 8.00e-02 | other | NA | -7.60e-01 | 0.0e+00 | BCL2L1,CDKN1A,JUN,MYC | NA |
| SRD5A1 | -2.10e-01 | enzyme | NA | -7.60e-01 | 2.0e-02 | IRS1,IRS2,Mt1,SREBF1 | NA |
| Sb202190 | NA | chemical drug | NA | -7.60e-01 | 4.0e-02 | BCL2,CCND1,CDKN1A,CRP,CXCL10,FGFR2,MAPK6,P4HA1,SERPINE1,SGK1,VDR | NA |
| CLEC11A | 1.00e-01 | growth factor | NA | -7.60e-01 | 0.0e+00 | BCL2,BCL2L1,CCL4,CD244,FHL2,GCSAM,LTB4R,STAR,TSC22D1 | 364 (20) |
| ZFTA-RELA | NA | fusion gene/product | NA | -7.80e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CX3CL1,CXCL10,IL1RN,IRF1,NFKB2,NFKBIA,RELB,SDC4,SMAD7,STAT5A,TAP1,TGM2 | NA |
| VCAN | 3.60e-01 | other | NA | -7.80e-01 | 1.0e-02 | CCL4,CDKN1A,CRISPLD2,HAS2,HAS3,IFI44L,IGFBP4,IL1RN,INHBB,LGALS3,NFKBIA,OAS2,PCSK5,PENK,TCF7L2 | 414 (19) |
| 2,3-bis(4-hydroxyphenyl)-propionitrile | NA | chemical reagent | NA | -7.80e-01 | 3.0e-02 | BCL2,CCND1,FDPS,H6PD,HDAC5,INPP4B | NA |
| TRAF3IP2 | -4.60e-01 | enzyme | NA | -7.80e-01 | 0.0e+00 | AGT,CCL24,CEBPD,CSF3,CX3CL1,CXCL10,FGF2,ITGAL,Madcam1,NFKBIZ,TRAF4 | 358 (12) |
| Ro31-8220 | NA | chemical drug | NA | -7.80e-01 | 1.0e-02 | BCL2,BCL2L1,CDKN1A,Mt1,SERPINE1,TRAF1 | NA |
| roscovitine | NA | chemical drug | NA | -7.90e-01 | 0.0e+00 | CCND1,CDKN1A,CFLAR,CYP2B6,JUN,MYC,PCYT1A,PPARG | 416 (25) |
| FEV | NA | transcription regulator | NA | -7.90e-01 | 3.0e-02 | CITED1,EN1,GABPB1,NR3C1,SLC7A8,TCF7L2,TPH1,TRPV2 | NA |
| HMGB1 | NA | transcription regulator | NA | -8.00e-01 | 0.0e+00 | ATG7,CCL4,CD83,CDKN1A,GLUL,IRS1,MERTK,MRC1,RELB,SMAD7,SREBF1,TLR2 | 383 (18) |
| tyrphostin AG 1478 | NA | chemical drug | NA | -8.00e-01 | 1.0e-02 | BCL2L1,CCND1,CDKN1A,FOXO3,HAS2,IRF1,PLAGL1,S100A10,SPHK1 | 407 (21) |
| MAX | 4.00e-02 | transcription regulator | NA | -8.10e-01 | 2.0e-02 | APEX1,CDKN1A,GADD45A,HK2,IRS2,JARID2,KLF6,MYC,RCC1 | NA |
| VHL | 2.60e-01 | transcription regulator | NA | -8.10e-01 | 0.0e+00 | ATF4,BCL2,BCL2L1,BHLHE40,BNIP3,CA12,CCND1,CDKN1A,EGLN3,EPAS1,FTL,HK2,LOX,NEK8,PISD,PREB,QPRT,TFRC,TRAF1 | 388 (19) |
| 1’-acetoxychavicol acetate | NA | chemical reagent | NA | -8.20e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CFLAR,MYC | 307 (16) |
| indirubin | NA | chemical drug | NA | -8.20e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,JUN,MYC | 377 (17) |
| evodiamine | NA | chemical - endogenous non-mammalian | NA | -8.20e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCND1,CFLAR,MYC | 324 (18) |
| TEAD3 | 2.70e-01 | transcription regulator | NA | -8.20e-01 | 2.0e-02 | EDNRA,NFKBIZ,NUAK1,PTPRO,SAMD5,THBS1 | NA |
| TCF20 | -4.00e-02 | transcription regulator | NA | -8.20e-01 | 3.0e-02 | ADARB1,ANK1,INPP5A,MYC,RGS20,SGK1,SUN2 | NA |
| GRN | 7.00e-02 | growth factor | NA | -8.20e-01 | 3.0e-02 | BCL2,CCL4,CCND1,CD300LF,CX3CR1,GPR34,LGALS3,MERTK,PICALM,SIRPA | NA |
| SFRP1 | -1.50e-01 | transmembrane receptor | NA | -8.20e-01 | 3.0e-02 | ACLY,CCND1,MYC,NAMPT,SERPINE1,SREBF1 | NA |
| MNT | NA | transcription regulator | NA | -8.20e-01 | 4.0e-02 | BNIP3,COQ8A,CXCL17,KLF6,MYC,TMEM252 | NA |
| genistein | NA | chemical drug | NA | -8.30e-01 | 0.0e+00 | ATF4,BCL2,BCL2L1,CCND1,CD8A,CDKN1A,CFLAR,CHEK2,CX3CL1,CX3CR1,CXCL10,EVI2A,GADD45A,HPGD,JUN,Mt1,MYC,NR3C1,PER1,PPARG,SERPINE1,SH2B2,SLC26A6,SPHK1,STAR,TFEB,VDR,WEE1,WNT5A,XYLT1 | 406 (24) |
| IRS1 | -1.36e+00 | enzyme | NA | -8.30e-01 | 0.0e+00 | CCND1,CDKN2C,CEBPD,COL7A1,FMO1,IGFBP4,IRS1,IRS2,KLF4,LEP,MYC,NRP1,PPARG,SREBF1,TRPC3,UCK1,WNT5A | 436 (22) |
| RRAS2 | 2.20e-01 | enzyme | NA | -8.30e-01 | 1.0e-02 | BVES,CSF3,FSCN1,IFI44L,MPZL2,NAMPT,NRP1,PGF,PLK2,RGS16,SCN1B,SERPINE1,TRIM14 | 164 (7) |
| NOS2 | NA | enzyme | NA | -8.40e-01 | 1.0e-02 | BCL2,BNIP3,CCL4,CDKN1A,CSF3R,FOXO1,IL1RN,IRS1,IRS2,KDR,KLF6,LEP,NFKBIA,PRDX6,PRF1,TNK2 | 415 (22) |
| TNFSF10 | -5.60e-01 | cytokine | NA | -8.40e-01 | 1.0e-02 | BCL2,BCL2L1,BIRC3,CFLAR,DDIT4,FADD,IL1RN,JUN,NFKBIA,PER1,TFRC,TNK2,TRAF1 | 361 (16) |
| FGF7 | 1.90e-01 | growth factor | NA | -8.50e-01 | 0.0e+00 | BCL2L1,CCND1,CDKN1A,CEBPD,FGFR2,HAS2,HAS3,IRF1,S100A10,SERPINE1,SREBF1 | 351 (19) |
| COP1 | NA | enzyme | NA | -8.50e-01 | 1.0e-02 | BCL2,CA12,CDKN1A,CISH,CXCL10,HR,HSPB8,IGFBP4,SREBF1 | 392 (16) |
| MIR17HG | NA | other | NA | -8.50e-01 | 5.0e-02 | BMPR2,CCND1,CDKN1A,CYLD,ECE1,GDF11,RGMA,TAX1BP1,TBX3,WNT5A | NA |
| PTK2 | 4.00e-02 | kinase | NA | -8.60e-01 | 2.0e-02 | BIRC3,CCND1,CDKN1A,IRS1,P4HA1,THBS1,TLL1 | NA |
| RBPJ | 7.00e-02 | transcription regulator | NA | -8.60e-01 | 0.0e+00 | AXIN2,CDKN1A,CORO1A,CRP,CSF3,CYTH4,EPHA4,FDPS,FGF10,FGF11,FGF2,GDF5,HAS2,HOXD3,IL1RN,INHBB,ITGAL,JUN,KDR,MAPK6,MYC,NFATC1,NRP2,PCED1B,PGF,PIK3CG,STAR,WNT5A | 418 (24) |
| thalidomide | NA | chemical drug | NA | -8.60e-01 | 0.0e+00 | BCL2L1,BIRC3,CFLAR,FGF2,KDR,NRP1,NRP2,SERPINE1,TRAF1 | 351 (17) |
| RB1 | -2.10e-01 | transcription regulator | NA | -8.70e-01 | 0.0e+00 | BCL2,BLM,BNIP3,CCND1,CD83,CDKN1A,CSF3,CYSLTR1,DCK,EDNRA,FANCA,FGF2,GADD45A,GMNN,GPR157,GPR17,GPR19,GPR75,GPT2,HUNK,IRS2,JUN,KDR,LRAT,MCAT,MET,MYC,NDUFA5,NFKB2,NFKBIA,NPAT,PER1,PPARG,PPFIBP1,PPT2,PROM1,PTPN4,RAB27A,RANBP1,REEP1,RELB,SERPINE1,TPO,ZFP36 | 418 (21) |
| Y 27632 | NA | chemical drug | NA | -8.70e-01 | 0.0e+00 | BMPR2,CDKN1A,COL12A1,CXCL10,HAS2,MYC,PPARG,SERPINE1,SOX17,THBS1 | 440 (21) |
| AGTR2 | -2.80e-01 | G-protein coupled receptor | NA | -8.70e-01 | 5.0e-02 | AGTR1,BCL2,BCL2L1,CX3CR1 | NA |
| RORA | 9.00e-01 | ligand-dependent nuclear receptor | NA | -8.70e-01 | 0.0e+00 | ACACB,BNIP3,CCL24,CCL4,CDKN1A,CISH,CXCL10,CYP2B6,GADD45A,HPGD,LPIN2,Mt1,NFKBIA,NR1D1,PRDX6,RDH16,RORA,SLC15A4,SLC16A10,SREBF1 | 374 (15) |
| ATP | NA | chemical - endogenous mammalian | NA | -8.80e-01 | 0.0e+00 | CCL4,CCND1,CD83,CXCL10,FOXO1,FOXO3,FZD8,IL1RN,MYC,NFATC1,NRP1,PLD2,PYCARD,SAT1,SERPINE1,SLC12A3,SPHK1,SREBF1,THBS1,TRPC3 | 376 (21) |
| S100A9 | 2.40e-01 | other | NA | -8.80e-01 | 4.0e-02 | ADAMTS1,APLN,BHLHE40,CCND1,CORO1A,CSF2RB,CXCL10,DDIT4,MCF2L,MYC,PER1,PTPRO,SGK1 | NA |
| embelin | NA | chemical - endogenous non-mammalian | NA | -8.80e-01 | 0.0e+00 | BCL2,BCL2L1,CCND1,CFLAR,MYC,PPARG | 258 (16) |
| diazoxide | NA | chemical drug | NA | -8.80e-01 | 0.0e+00 | ADRB3,BCL2,BCL2L1,KCNJ8,LEP,MYC | 357 (21) |
| FGF9 | -1.80e-01 | growth factor | NA | -8.80e-01 | 3.0e-02 | CCND1,CSF3,FGF10,STAR | NA |
| BSCL2 | -1.00e-02 | other | NA | -8.80e-01 | 2.0e-02 | ADRB3,CCND1,CIDEC,GRIA2,LEP,MARK1,PPARG | NA |
| VEGFA | 1.30e-01 | growth factor | NA | -8.80e-01 | 0.0e+00 | ADAMTS1,ADRB3,BCL2,BCL6B,CCND1,CD244,CD83,CDKN1A,CSF3,CXCL10,DBT,FGF2,GRIA2,IGFBP4,IKBKE,ITGA1,KDR,MMP15,NFATC1,NRP1,PIK3CG,SERPINE1,THBS1,TOMM20,TOMM70 | 377 (21) |
| Tnf (family) | NA | group | NA | -8.90e-01 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CCL4,CCND1,CD22,CFLAR,CIRBP,CX3CL1,CXCL10,CXCL11,CYP2B6,GJA5,HSD11B1,IKBKE,IL1R2,IL1RN,IRAK2,JUN,KDR,MYC,NFKBIA,NT5E,PPARG,SERPINE1,TGM2,TLR2,TRAF1 | 243 (12) |
| HRAS | -2.00e-02 | enzyme | NA | -8.90e-01 | 0.0e+00 | ACLY,ADARB1,ALDH1A3,BCL2,BCL2L1,BIRC3,BNIP3,BTG2,CBX2,CCND1,CDK18,CDKN1A,CDON,CEBPD,CGREF1,CISH,CRP,CSF3,CSRP2,CXCL10,CXCL11,CXXC5,DIXDC1,DUSP9,ELK3,FGF2,FOXO1,GADD45G,HAS2,HDC,IGFBP4,JUN,KLF6,LBH,MET,MTHFD1L,MYC,NFKBIA,NRP1,NUCKS1,PCYT1A,PGF,PML,PRDX6,RASA3,SERPINE1,SIRPA,SQLE,SREBF1,TAP1,TBX3,TGM2,THBS1,TINAGL1,TPH1,TPO,TRPC3,TSC22D1,TYRO3 | 425 (22) |
| mir-8 | NA | microRNA | NA | -9.00e-01 | 0.0e+00 | ABL2,ACE2,ADAMTS1,BCL2,CCND1,CDKN1A,ERRFI1,FGFR2,GRB7,KDR,KLF4,LOX,MET,MYC,Pmaip1,PROM1,ROCK2,SOX17,STAT5A,TOB1,ZFP36,ZFPM2 | 394 (22) |
| 3M-011 | NA | chemical reagent | NA | -9.00e-01 | 0.0e+00 | BCL2,BCL2L1,CCL4,CD83,CXCL10,MYC | 366 (16) |
| TNC | 6.00e-02 | other | NA | -9.00e-01 | 0.0e+00 | BCL2,CCL4,CD8A,CDKN1A,EDNRA,MET,MYC | 350 (21) |
| TLR2 | -9.30e-01 | transmembrane receptor | NA | -9.00e-01 | 1.0e-02 | CCL4,CDKN1A,CEBPD,CISH,CRP,CSF3,CXCL10,CYLD,FOXO1,GADD45A,IL1RN,IRF1,ITGB7,LEP,TLR2,VDR | NA |
| CDK19 | -2.70e-01 | kinase | NA | -9.00e-01 | 0.0e+00 | BTG2,CDKN1A,DDIT4,GADD45A,JUN,KLF4,MYC,PLK2,SAT1,SPHK1,TBX3,TRAF4,TSC22D1,UPP1,VDR | NA |
| mir-802 | NA | microRNA | NA | -9.00e-01 | 1.0e-02 | ARRDC3,DTX4,EFNB1,EPHA4,FGF2,FMO1,FMO2,HECW2,HPGD,PIK3C2A,PIK3CG,PNPLA8,SDC4 | NA |
| EML4-ALK | NA | fusion gene/product | NA | -9.00e-01 | 0.0e+00 | BCL2,CDKN1A,CDKN2C,IL6R,IRF1,MET,MITF,PPARG,RAB27A,SERPINE1,TLR2 | 328 (16) |
| MYD88 | 2.20e-01 | other | NA | -9.10e-01 | 0.0e+00 | AGTR1,ATF4,AXIN2,BLM,CCL4,CD38,CD83,CEBPD,CFLAR,CISH,CSF3,CXCL10,EDNRB,FGF10,FOXO1,HDC,IKBKE,IL1RN,IRAK2,IRF1,ITGB7,JUN,MAFF,MET,MRC1,MYC,NFKB2,NFKBIA,NFKBIZ,PRF1,PSTPIP2,RELB,SAMHD1,SERPINE1,TFRC,TLR2,TRAF6,TSC22D1 | 381 (14) |
| PRKAA2 | 9.00e-02 | kinase | NA | -9.10e-01 | 0.0e+00 | BCL2,CDKN1A,CYP2B6,FGFR2,FOXO3,HIGD1A,Ifi47,IGFBP4,LEP,NFKBIA,PPARG,PTPN11,SLC16A1,SREBF1,TGM2 | 379 (23) |
| cholesterol | NA | chemical - endogenous mammalian | NA | -9.10e-01 | 1.0e-02 | ABCA6,ACLY,AGT,ATF4,CCL4,CXCL10,FDPS,FGF2,IL1RN,LGALS3,MITF,PPARD,PPARG,RGS16,SLC7A5,SQLE,SREBF1,THBS1,ZFPM2 | NA |
| methylselenic acid | NA | chemical reagent | NA | -9.10e-01 | 0.0e+00 | ABCA5,ADAMTS1,BACH1,BCL2L1,BIRC3,CCND1,CDKN1A,CFLAR,CHEK2,CORO1A,CREB3L2,FKBP5,GADD45A,INPP4B,IRF1,JUN,KLF4,MYC,NDRG1,NFIL3,RAPGEF4,RND3,SAT1,SEC24D,SGK1,STX1A,TLR2,TMPRSS2,ZBTB16 | 479 (23) |
| IL24 | -1.40e-01 | cytokine | NA | -9.20e-01 | 0.0e+00 | BATF2,BCL2,BCL2L1,CCND1,FADD,GADD45A,GADD45G,XRCC6 | 377 (18) |
| WNT3A | NA | cytokine | NA | -9.20e-01 | 0.0e+00 | ALDH1A3,AXIN2,BCL2,BCS1L,CCND1,COX5A,CXCL10,DDIT4,EFNB1,EN1,EPAS1,FHL2,GADD45G,HAS2,HAS3,Irgm1,IRS1,IRS2,JUN,KDR,KLF4,LBH,MITF,MRGPRF,MYC,NFATC1,PPARG,ROCK2,SDC4,SGMS1,SLC7A1,SOX17,TBX3,TCF3,TCF7L2,THBS1,WNT5A | 384 (20) |
| DNMT3A | -2.50e-01 | enzyme | NA | -9.30e-01 | 0.0e+00 | ADCY5,ADORA1,Akap17b,APLN,CD38,CYSLTR1,EDNRA,FGF2,FOXO1,GATA6,IRF1,IRS1,JUN,Mt1,MYH7B,PIK3C2B,PIK3CG,PLK2,RGMA,RGS16,SDC4,SKIL,SPHK1,TGM2,TSC22D1,TYK2,XRCC2 | 371 (14) |
| mir-486 | NA | microRNA | NA | -9.30e-01 | 0.0e+00 | ADARB1,ARID4B,FOXO1,GABRE,PIK3AP1,TOB1 | NA |
| clozapine | NA | chemical drug | NA | -9.30e-01 | 5.0e-02 | FDPS,GRIA2,HTR7,SGK1,SREBF1,WNT5A | NA |
| RUNX1 | -3.90e-01 | transcription regulator | NA | -9.40e-01 | 0.0e+00 | ALOX12,ANK1,APEX1,ATF4,BTG2,CCND1,CD22,CD244,CDKN1A,CSF2RB,EDEM1,EPAS1,FSCN1,GNA15,GNL3,GPAM,GPATCH4,Igtp,IL6R,Irgm1,ITGAL,LTB4R,MAP3K6,MET,Mt1,MYC,NFIL3,Oasl2,OGG1,PLEK,PLXND1,Pmaip1,SERPINE1,SOX17,TRIB1,UPP1,ZBTB16 | 397 (22) |
| D-fructose | NA | chemical - endogenous mammalian | NA | -9.40e-01 | 2.0e-02 | AGT,CXCL10,PPARG,SLC2A5,SREBF1,THBS1 | NA |
| bromodeoxyuridine | NA | chemical drug | NA | -9.50e-01 | 3.0e-02 | CXCL10,GDF5,IGFBP4,IRF1,PML,SERPINE1 | NA |
| BCL2 | -9.90e-01 | transporter | NA | -9.50e-01 | 1.0e-02 | BCL2,BCL2L1,BNIP3,CCND1,CDKN1A,GADD45A,NDRG1,NFKBIA,PRF1,SNAP25,SPHK1 | 333 (18) |
| S100A4 | 2.90e-01 | other | NA | -9.50e-01 | 2.0e-02 | BNIP3,CCL24,CDKN1A,CSF3,THBS1,TPO | NA |
| BCL11B | -3.20e-01 | transcription regulator | NA | -9.60e-01 | 3.0e-02 | ADORA1,BCL2,CDKN1A,NRP1,PLXND1,RORA,ZBTB16 | NA |
| PF-4878691 | NA | chemical drug | NA | -9.70e-01 | 1.0e-02 | BCL2,BCL2L1,CCL4,CD83,CXCL10,MYC | NA |
| E2F4 | 1.00e-01 | transcription regulator | NA | -9.70e-01 | 1.0e-02 | BCL2,BNIP3,CCND1,CDKN1A,CDKN2C,CHEK2,EPAS1,GMNN,MYC,NPAT,POLD1,PPARG,PPP1R13B,RANBP1,SERPINE1,SLC3A2,STAM,TP53INP1 | NA |
| TAL1 | -3.20e-01 | transcription regulator | NA | -9.70e-01 | 1.0e-02 | BCL2,CDKN1A,CEP70,CYLD,ELOVL4,GDF5,JUN,KCNJ9,MAP3K4,MYC,MYO1E,NFKBIZ,RASD1,RIPK4,SLC4A11,TMEFF1,TOB1,XRCC6 | NA |
| testosterone | NA | chemical - endogenous mammalian | NA | -9.70e-01 | 0.0e+00 | AMD1,APLN,BCL2,BCL2L1,BMPR2,CCND1,CDKN1A,COX5A,CRHR2,CRP,DDIT4,FADD,FGF10,FGFR2,FGFR3,FOXO1,GADD45A,HDC,INHBB,IRS1,IRS2,JUN,LEP,Mt1,NDRG1,NFKB2,NFKBIA,PDE3B,PPARG,SLC6A9,STAR,THBS1,TYK2,WNT5A | 512 (22) |
| PPP5C | 2.20e-01 | phosphatase | NA | -9.80e-01 | 0.0e+00 | CCND1,CDKN1A,MYC,SGK1 | 392 (19) |
| MTA1 | -1.40e-01 | transcription regulator | NA | -9.90e-01 | 1.0e-02 | APEX1,AXIN2,BCL2L1,CCND1,HUNK,MYC,SLC16A10 | 387 (18) |
| enalapril | NA | biologic drug | NA | -9.90e-01 | 0.0e+00 | ACE2,ADAMTS1,AGT,KDR,LGALS3,LOX,MAS1,MYC,S100A10,SERPINE1 | 369 (15) |
| GFI1 | -5.00e-02 | transcription regulator | NA | -9.90e-01 | 0.0e+00 | CDKN1A,CFLAR,FOXO1,GADD45G,IL6R,IRAK2,IRF1,ITGB7,JAK3,JUN,MAFF,MAP3K5,MYC,NFKB2,NFKBIA,NOD1,NT5E,PER3,Pmaip1,RAPGEF4,RELB,SGK1,TNK2,TRAF5,VDR | 404 (17) |
| JAK2 | 1.60e-01 | kinase | NA | -1.00e+00 | 0.0e+00 | BCL2L1,CCND1,CDKN1A,CFLAR,CXCL10,FGF2,FOXO1,GBP2,IRF1,Milr1,MYC,NFKBIZ,PLK2,SDC4,SEMA6B,SKIL,TAP1,TGM2,THBS1,TP53INP1,TSC22D1 | 351 (16) |
| STEAP4 | 3.10e-01 | enzyme | NA | -1.00e+00 | 0.0e+00 | ATF4,LEP,TFEB,TRAF4 | NA |
| cortistatin A | NA | chemical reagent | NA | -1.00e+00 | 0.0e+00 | BHLHE40,ETV6,IRF1,JARID2 | NA |
| RFC4 | 4.10e-01 | enzyme | NA | -1.00e+00 | 0.0e+00 | BCL2,CCND1,MYC,NRARP | 252 (11) |
| trans-hydroxytamoxifen | NA | chemical drug | NA | -1.00e+00 | 0.0e+00 | ACVR1,BRPF1,BTG1,DDIT4,FGF10,FMN2,FMO5,FZD8,IGFBP4,INHBB,IRF6,KLF6,LHFPL2,LOX,MYBL1,NDRG1,PLK2,RND3 | NA |
| NUMB | 3.30e-01 | other | NA | -1.00e+00 | 0.0e+00 | BCL2L1,BIRC3,CDKN1A,CFLAR,PROM1 | 362 (16) |
| PPP2R5C | NA | other | NA | -1.00e+00 | 1.0e-02 | BCL2,BCL2L1,BIRC3,RELB | 390 (17) |
| ACTL6A | 1.80e-01 | other | NA | -1.00e+00 | 1.0e-02 | BCL2L1,CCND1,CDKN1A,MYC,TP53INP1 | 382 (19) |
| 11,12-epoxyeicosatrienoic acid | NA | chemical - endogenous mammalian | NA | -1.00e+00 | 1.0e-02 | EPHX2,NFKBIA,PIK3CG,PPARG | NA |
| PD 169316 | NA | chemical drug | NA | -1.00e+00 | 1.0e-02 | BIRC3,CCND1,CDKN1A,MAPK6 | NA |
| KIF3A | -4.60e-01 | enzyme | NA | -1.00e+00 | 2.0e-02 | ACLY,CDKN1A,FDPS,MYC | NA |
| S-(2,3-bispalmitoyloxypropyl)-cysteine-GDPKHPKSF | NA | chemical reagent | NA | -1.00e+00 | 2.0e-02 | CCL4,CXCL10,SERPINE1,TLR2 | NA |
| EIF4B | -2.00e-01 | translation regulator | NA | -1.00e+00 | 2.0e-02 | CXCL17,IL1R2,ITGAL,PRF1 | NA |
| PARP2 | -3.70e-01 | enzyme | NA | -1.00e+00 | 2.0e-02 | CCL4,CD83,LEP,PPARG | NA |
| Rb | NA | group | NA | -1.00e+00 | 3.0e-02 | CCND1,CDKN1A,FGFR2,GMNN,MYC,PCYT1A,POLD1,TPO | NA |
| TF | 6.00e-02 | transporter | NA | -1.00e+00 | 3.0e-02 | CCND1,CX3CL1,NFKBIA,TFRC | NA |
| ROCK | NA | group | NA | -1.00e+00 | 3.0e-02 | CCND1,CDKN1A,MAFK,MYC,PPARG,THBS1 | NA |
| LAMA4 | 5.00e-02 | enzyme | NA | -1.00e+00 | 3.0e-02 | CCND1,IDH1,IL6R,MET,MGST2,PIK3CG,ROCK2,SIPA1,THBS1 | NA |
| pexidartinib | NA | chemical drug | NA | -1.00e+00 | 3.0e-02 | BCL2,CD300C,CDON,ERRFI1,FAM102B,FOXO1,ITGAL,PI4K2B,PRF1 | NA |
| ShK-223 | NA | chemical reagent | NA | -1.00e+00 | 4.0e-02 | ATG7,CSF3R,CX3CR1,IL1R2,IL1RN,MERTK,PIK3CB,PIK3CG,PLD2 | NA |
| HR | -6.90e-01 | transcription regulator | NA | -1.00e+00 | 5.0e-02 | AMD1,FADD,GPD1L,IL1R2,VDR | NA |
| U0126 | NA | chemical drug | NA | -1.01e+00 | 0.0e+00 | ACLY,AGT,APLNR,ATF4,AXIN2,BCL2,BCL2L1,BHLHE40,BIRC3,CCL4,CCND1,CDK18,CDKN1A,CEBPD,CFLAR,CSF3,CXCL10,CXCL11,CYP2B6,DBP,EDNRB,ERRFI1,FAM53B,FGF2,FGFR2,FKBP5,FLT3LG,FMO3,GPR34,GRIA2,HPGD,IL1R2,IRF1,JUN,KDR,KIFC3,LEP,MET,MYC,NFATC1,NR3C2,PER1,PLAGL1,PLK2,PML,PPARD,PPARG,RND3,SCN1B,SERPINE1,SGK1,SIRPA,SREBF1,STAR,TCF7L2,TGM2,THBS1,TLR2,TRAF1,TRIB1,TSC22D1,ZFP36 | 445 (20) |
| E. coli B4 lipopolysaccharide | NA | chemical toxicant | NA | -1.01e+00 | 0.0e+00 | BCL2,BCL2L1,CA13,CCL4,CD38,CD83,CSF3,CXCL10,CYTH4,FADD,FGL2,GADD45G,GBP2,GBP4,HK2,HSPB8,Igtp,IL1RN,LILRB3,MDFIC,MRC1,NFKBIA,Oasl2,PLEK,PYCARD,RAB7B,RELB,TAP1,TLR2,TRAF5,TRAM2 | 335 (17) |
| temozolomide | NA | chemical drug | NA | -1.01e+00 | 0.0e+00 | BCL2,BCL2L1,CDKN1A,CFLAR,CXCL10,NFKBIA,QPRT | 355 (21) |
| romidepsin | NA | biologic drug | NA | -1.02e+00 | 1.0e-02 | BCL2L1,CCND1,CDKN1A,CFLAR,CXCL10,FGF2,GADD45G,JUN,MYC | NA |
| SYK | -3.60e-01 | kinase | NA | -1.02e+00 | 0.0e+00 | BCL2,BIRC3,CCL4,CCND1,CXCL10,FGL2,GADD45A,IRF1,OAS2,RASSF4,SREBF1,TP53INP1,TSC22D1 | 384 (23) |
| IRS2 | -9.20e-01 | enzyme | NA | -1.02e+00 | 0.0e+00 | ACLY,CCND1,IRS1,LEP,MYC,PPARG,SREBF1 | 424 (21) |
| tyrphostin AG490 | NA | chemical drug | NA | -1.02e+00 | 1.0e-02 | AGT,BCL2,BCL2L1,BIRC3,CDKN1A,FGF2,HPGD,IRF1,MYC,S100A10,STAR | 403 (21) |
| miR-486-5p (and other miRNAs w/seed CCUGUAC) | NA | mature microRNA | NA | -1.03e+00 | 0.0e+00 | ADARB1,ARID4B,FOXO1,GABRE,PIK3AP1,TOB1 | NA |
| miR-378a-3p (and other miRNAs w/seed CUGGACU) | NA | mature microRNA | NA | -1.03e+00 | 0.0e+00 | FOXO1,FOXO3,SUFU,TRAF1 | NA |
| miR-30a-3p (and other miRNAs w/seed UUUCAGU) | NA | mature microRNA | NA | -1.03e+00 | 2.0e-02 | LIMA1,PIK3C2A,SLC7A6,THBS1 | NA |
| RORC | NA | ligand-dependent nuclear receptor | NA | -1.03e+00 | 3.0e-02 | ACACB,CISH,CYP2B6,GPT2,HK2,HPGD,LPIN2,Mt1,MYC,RDH16,RORA,SLC15A4,SLC16A10,SLC7A5,ZBTB16 | NA |
| gefitinib | NA | chemical drug | NA | -1.04e+00 | 0.0e+00 | ADAMTS1,ADAMTS15,BCL2,BCL2L1,BTG2,CCND1,CEBPD,CFLAR,CHEK2,FGFR2,FMO2,FRAT2,FSCN1,GCNT3,IL1R2,MAFF,MMP15,MTBP,NFKB2,NRP2,PCDH12,PPARG,PTGER1,RELB,TGM2,TLR2,TP53INP1,TRAF1,XRCC2 | 409 (17) |
| spironolactone | NA | chemical drug | NA | -1.04e+00 | 0.0e+00 | ADRB3,BCL2,CDKN1A,EDNRB,FGF2,FKBP5,HSD11B2,LGALS3,LOX,NR3C1,NR3C2,PER1,PGF,PPARG,STAR | 328 (23) |
| FOXC1 | -8.00e-02 | transcription regulator | NA | -1.04e+00 | 3.0e-02 | FGFR3,FOXO1,GBP4,IRF1,IRF6,OAS2,SAMHD1,SATB2,SERPINE1,TRIM14,TSC22D1,WNT5A | NA |
| TSH | NA | complex | NA | -1.05e+00 | 0.0e+00 | CCND1,CDKN1A,FOXO1,IL1RN,KDR,Mt1,MYC,PPARD,TPO,TTF2,WNT5A | 361 (22) |
| mir-182 | NA | microRNA | NA | -1.05e+00 | 0.0e+00 | CARD11,CCL24,FOXO1,FOXO3,GADD45G,KLF4,MRC1,PGF,PRF1,TCF3 | NA |
| ID3 | -6.60e-01 | transcription regulator | NA | -1.06e+00 | 0.0e+00 | BCL2,BCL2L1,BTG2,CD83,CDKN1A,CDKN2C,CSF2RB,DTX2,FLT3LG,FOXO1,FOXO3,GADD45G,GNL3,IGFBP4,IL2RB,IL6R,INHBB,IRF6,KLF6,MYC,NFATC1,PIK3C2B,RAPGEF4,RELB,RORA,SMAD7,TRAF1,TRAF4,TRAF5,ZBTB16 | 346 (20) |
| TIFA | 2.40e-01 | other | NA | -1.07e+00 | 0.0e+00 | BCL2,BCL2L1,CXCL10,NFKBIA | 339 (15) |
| GAS2L3 | 3.50e-01 | other | NA | -1.07e+00 | 0.0e+00 | BTG2,CDKN1A,PLK2,SAT1 | NA |
| MFN2 | 2.20e-01 | enzyme | NA | -1.07e+00 | 1.0e-02 | ATF4,BCL2,BNIP3,CX3CL1 | 390 (16) |
| PLCG1 | -3.80e-01 | enzyme | NA | -1.07e+00 | 1.0e-02 | CCND1,KDR,SERPINE1,THBS1 | 380 (23) |
| lipid | NA | chemical - endogenous mammalian | NA | -1.07e+00 | 1.0e-02 | ACLY,AGT,FDPS,PCYT1A,SQLE,SREBF1 | NA |
| SULF2 | -4.00e-02 | enzyme | NA | -1.07e+00 | 2.0e-02 | AXIN2,BCL2,CCND1,NOG | NA |
| fasudil | NA | chemical drug | NA | -1.07e+00 | 4.0e-02 | BCL2,BCL2L1,JUN,MRC1,ROCK2 | NA |
| BAK1 | 5.00e-02 | other | NA | -1.07e+00 | 5.0e-02 | CDKN1A,CXCL10,EDEM1,TYK2 | NA |
| MSB0011359C | NA | biologic drug | NA | -1.07e+00 | 0.0e+00 | BTG2,CDKN1A,CXCL10,EDNRB,FANCA,GBP5,HK2,IRF1,LYVE1,Mt1,OGFRL1,PRF1,SKIL,TGM2 | NA |
| FFAR3 | NA | G-protein coupled receptor | NA | -1.07e+00 | 0.0e+00 | ADGRV1,CBS/LOC102724560,CXCL10,GBP2,KCNH1,LEP,MLPH,PAG1,PDXP,PPARG,SCN1B,SLC12A7,STAR,Zim1 | 198 (7) |
| miR-125b-5p (and other miRNAs w/seed CCCUGAG) | NA | mature microRNA | NA | -1.09e+00 | 1.0e-02 | ADAMTS1,APLN,BCL2,H3-3A/H3-3B,HK2,IL1RN,IL6R,JARID2,JUN,PPT2,PROM1 | 420 (16) |
| H-7 | NA | chemical - kinase inhibitor | NA | -1.09e+00 | 0.0e+00 | ECE1,HDC,Mt1,MYC,SERPINE1,STAR,VDR | 396 (22) |
| FUT8 | 3.10e-01 | enzyme | NA | -1.09e+00 | 2.0e-02 | PROM1,SMAD7,SQLE,TFRC | NA |
| AZGP1 | -2.70e-01 | transporter | NA | -1.09e+00 | 2.0e-02 | BCL2L1,CCND1,HK2,MYC | NA |
| EZH2 | -1.00e-01 | transcription regulator | NA | -1.09e+00 | 0.0e+00 | ABL2,APPBP2,AXIN2,BCL2,BCL2L1,BIRC3,CCND1,CDKN1A,CRISPLD2,CSF3,CSF3R,CX3CL1,CXCL10,CXCL11,DENND2A,EPAS1,FGF11,FKBP5,FOXO3,GATA6,HSD11B2,IL6R,ITGA1,KLF4,MPZL2,MYC,NDRG1,NFKBIA,PCDH20,PER1,PGF,POU2F3,PPARG,PROM1,RORA,SOX17,TBX3,TMPRSS2,TRAF6,VDR,ZBTB16 | 382 (26) |
| ZBTB16 | 7.40e-01 | transcription regulator | NA | -1.10e+00 | 0.0e+00 | BACH2,CCND1,CD180,CD244,CD38,CD83,CD8A,CDKN1A,CXCL10,Dgke,FGFR3,FOXO1,GPT2,H6PD,HOXC6,HPGD,IRF6,KCNJ8,LTB4R,MYC,NFKBIZ,PIK3CB,Pla2g12a,POLD1,RORA,SGMS1,TCF7L2,TSC22D1,ZBTB16 | 344 (21) |
| miR-23a-3p (and other miRNAs w/seed UCACAUU) | NA | mature microRNA | NA | -1.10e+00 | 5.0e-02 | ATAT1,HK2,IL6R,MET | NA |
| E. coli B5 lipopolysaccharide | NA | chemical - endogenous non-mammalian | NA | -1.10e+00 | 0.0e+00 | ADAMTS1,ADH1C,BHLHE40,BIRC3,CCL24,CCL4,CCND1,CD83,CDKN1A,CSF3,CSF3R,CX3CL1,CX3CR1,CXCL10,ERRFI1,FMO1,GBP2,HSD11B1,Igtp,IL1R2,IL6R,INHBB,IRF1,ITGAL,NFKBIA,SERPINE1,TGM2,THBS1,TLR2,TPO | 393 (15) |
| sulfasalazine | NA | chemical drug | NA | -1.10e+00 | 1.0e-02 | BCL2L1,CCND1,NFKBIA,NR3C1 | 408 (20) |
| FAM83A | 1.03e+00 | other | NA | -1.10e+00 | 2.0e-02 | BCL2,BCL2L1,PPARG,SREBF1 | NA |
| GATA4 | -2.00e-01 | transcription regulator | NA | -1.11e+00 | 0.0e+00 | ACE2,ADORA1,AGTR1,ATG7,BCL2,BCL2L1,CA12,CCL4,FGF2,GATA6,GJA5,HSPB7,INHBB,IRF6,JUN,MYC,OVOL1,PLIN4,PML,PTPRB,SLC25A29,STAR,TGM2 | NA |
| PER2 | -1.30e-01 | transcription regulator | NA | -1.11e+00 | 0.0e+00 | CCND1,DBP,LEP,PER1,PER3 | 221 (12) |
| HOXC6 | -8.10e-01 | transcription regulator | NA | -1.11e+00 | 1.0e-02 | BCL2,ERRFI1,FGFR2,HOXC6,NFKB2,SENP8 | NA |
| alendronic acid | NA | chemical drug | NA | -1.11e+00 | 1.0e-02 | BCL2,CCL24,CRP,EFNB1,FGF2,FMO3 | NA |
| Mir122a,b | NA | group | NA | -1.11e+00 | 3.0e-02 | AGT,BCL2,BCL2L1,GALNT10,NR3C1,ROCK2 | NA |
| TFRC | 8.40e-01 | transporter | NA | -1.12e+00 | 0.0e+00 | ATF4,BNIP3,CDKN1A,DDIT4,FTL,GADD45A,HK2,JUN,PIP5K1B,Pmaip1,PPARG | 219 (12) |
| STK24 | 2.10e-01 | kinase | NA | -1.13e+00 | 0.0e+00 | ACACB,ACLY,GPAM,PPARG | NA |
| GNAI2 | 2.40e-01 | enzyme | NA | -1.13e+00 | 4.0e-02 | BHLHE40,BNIP3,CCND1,ITGAL | NA |
| Sn50 peptide | NA | chemical toxicant | NA | -1.13e+00 | 1.0e-02 | BCL2,BCL2L1,BIRC3,CRP,CXCL10,MYC,PPARG,SERPINE1 | 385 (17) |
| TEAD2 | -6.90e-01 | transcription regulator | NA | -1.13e+00 | 0.0e+00 | CCND1,EDNRA,FGFR4,NFKBIZ,NUAK1,PTPRO,SAMD5,THBS1 | NA |
| PAX5 | -6.00e-02 | transcription regulator | NA | -1.13e+00 | 0.0e+00 | BCL2,BCL2L1,CCND1,CD22,HK2,MET,MYC,NR3C1,SLC16A10 | 412 (24) |
| Srgn | 2.00e-02 | other | NA | -1.13e+00 | 0.0e+00 | BANP,CD300LF,CD83,CD8A,Irgm1,SBK1,THBS1 | NA |
| TIMP3 | 3.20e-01 | other | NA | -1.13e+00 | 1.0e-02 | JUN,KLF4,MET,SERPINE1,SKIL,SMAD7,THBS1 | 452 (21) |
| Calmodulin | NA | group | NA | -1.13e+00 | 1.0e-02 | BCL2,CPNE5,DLG3,KDR,NECAB1,RIMBP2,STX1A | NA |
| CYLD | 6.90e-01 | transcription regulator | NA | -1.14e+00 | 1.0e-02 | AXIN2,JUN,NFKB2,NFKBIA,RELB,SERPINE1 | 398 (22) |
| Creb | NA | group | NA | -1.15e+00 | 0.0e+00 | ABL2,ATG7,BCL2,CCND1,CDKN1A,CEBPD,CFLAR,CIDEC,CXCL10,FSCN1,GJA5,HAS2,HPGD,HSPB8,IRS2,JUN,LEP,MITF,NR3C1,PDE3B,PENK,PER1,PPARG,PPFIBP1,SKIL,SOX17,STAR,TFEB | 343 (23) |
| PDGFB | -2.60e-01 | growth factor | NA | -1.15e+00 | 3.0e-02 | CCND1,FGF10,FOXO1,FOXO3,IL1RN,MYC,THBS1 | NA |
| SRA1 | 1.20e-01 | transcription regulator | NA | -1.15e+00 | 1.0e-02 | PPARG,STAR,THBS1,TMPRSS2 | NA |
| NOSTRIN | 5.00e-01 | transcription regulator | NA | -1.15e+00 | 5.0e-02 | BCL2,KDR,PGF,THBS1 | NA |
| Tcf7 | -2.10e-01 | transcription regulator | NA | -1.16e+00 | 0.0e+00 | ARHGAP20,BACH1,BCL2,BMPR2,C3orf70,CCL4,CD83,CDKN1A,CEBPD,CISH,CX3CR1,ELK3,EN1,FDPS,GPD1L,IL2RB,ITSN1,KLF6,LONRF1,LRIG1,NHSL2,OSBPL5,PENK,PI4K2A,PILRB,PIP5K1B,Pmaip1,PPARG,PPT2,PRF1,PTPRO,RASGEF1B,SGMS1,SQLE,TSC22D1,USP27X,ZNF467 | 310 (7) |
| BTK | -2.40e-01 | kinase | NA | -1.16e+00 | 0.0e+00 | BCL2L1,CCL4,CD38,CDKN1A,CISH,CXCL10,FOXO1,IFI44L,IRF1,JUN,MTHFD2,MYC,NFATC1,NFKB2,OAS2,RELB | 344 (19) |
| FTI-277 | NA | chemical reagent | NA | -1.17e+00 | 1.0e-02 | BCL2,CCND1,MYC,SERPINE1 | 349 (23) |
| actinomycin D | NA | biologic drug | NA | -1.17e+00 | 0.0e+00 | AGT,ATF4,BCL2,BIRC3,CCND1,CD38,CDKN1A,CFLAR,DDIT4,EGLN3,EPAS1,ERRFI1,FADD,GADD45A,IGFBP4,IL1R2,IRF1,IRS1,IRS2,JUN,LTB4R,Mt1,MYC,PPARG,ROCK2,SERPINE1,SKIL,SMAD7,SPHK1,TAP1,TLR2,TRAF1,VDR,VIP | 418 (19) |
| MAP3K7 | 2.90e-01 | kinase | NA | -1.17e+00 | 2.0e-02 | BIRC3,CXCL10,GBP2,IRF1,JUN,OAS2,SERPINE1,WNT5A | NA |
| NCOR2 | 3.80e-01 | transcription regulator | NA | -1.17e+00 | 0.0e+00 | AXIN2,BCL2,BIRC3,CCND1,CDKN1A,JUN,LEP,MYC,NFATC1,RELB,STAR | 394 (23) |
| BIRC3 | 6.50e-01 | enzyme | NA | -1.17e+00 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CSF3,NFKB2,NFKBIA | 273 (12) |
| FABP4 | 4.60e-01 | transporter | NA | -1.18e+00 | 4.0e-02 | LTB4R,PPARD,PPARG,PYCARD | NA |
| EBF4 | 7.00e-02 | transcription regulator | NA | -1.19e+00 | 0.0e+00 | CDKN1A,IL2RB,JAK3,PRF1 | NA |
| KAT5 | 2.00e-01 | transcription regulator | NA | -1.19e+00 | 1.0e-02 | ADAMTS1,APEX1,CCND1,CDKN1A,CDKN2C,GADD45A,GPAM,IRS1,MYC,NT5E,OTUB2,PCDH20,PRR5L,SLC19A1,SLC6A9,SOX17 | NA |
| PI-103 | NA | chemical drug | NA | -1.20e+00 | 0.0e+00 | BCL2,CCND1,CFLAR,CIDEC,FDPS | 426 (24) |
| IGF2 | -3.30e-01 | growth factor | NA | -1.20e+00 | 0.0e+00 | ARL4A,CCND1,CDKN1A,CRY1,GADD45A,GATA6,IDH1,IGFBP4,LEP,MYC,NDRG1,NFKBIA,RGS16,SAT1,SERPINE1,SREBF1 | 393 (22) |
| mifepristone | NA | chemical drug | NA | -1.20e+00 | 0.0e+00 | ARID4B,BCL2,BCL2L1,CCND1,CDKN1A,CEBPD,CISH,DDIT4,EDNRB,ERRFI1,FGF2,FKBP5,GAL,H6PD,HAS2,HDC,HPGD,HSD11B1,INHBB,IRS2,JAK3,JUN,KLF4,LOX,Mt1,MYC,NDRG1,NFKBIA,NR3C1,PLK2,SERPINE1,SNAP25,SOX17,STAR,STAT5A,TAX1BP1,TMPRSS2,VDR | 440 (20) |
| miR-122-5p (miRNAs w/seed GGAGUGU) | NA | mature microRNA | NA | -1.20e+00 | 2.0e-02 | AACS,BACH2,EGLN3,GALNT10,NFATC1,SLC7A1,TRIB1 | NA |
| IL12 (family) | NA | group | NA | -1.20e+00 | 0.0e+00 | ADAM19,BCL2,BCL2L1,CCL4,CD244,CD8A,CFLAR,DDIT4,GNA15,IRF1,MYC,NFIL3,NFKBIZ,NRP1,PRF1,SAMHD1,TFRC | 397 (18) |
| CCK | -1.80e-01 | other | NA | -1.21e+00 | 2.0e-02 | CFLAR,CXCL10,MET,PENK | NA |
| NC410 | NA | biologic drug | NA | -1.21e+00 | 0.0e+00 | BCL2,BTG2,CCL24,CDKN1A,CXCL10,EDNRB,FANCA,GBP5,HK2,IL1R2,IRF1,LYVE1,MRC1,Mt1,OGFRL1,PRF1,SKIL,TGM2 | NA |
| WNT5A | -1.36e+00 | cytokine | NA | -1.22e+00 | 0.0e+00 | AXIN2,BCL2,BCL2L1,BMPER,BTG2,CCND1,CD38,CSF3,CXCL10,EPHA4,FZD8,GDF5,INHBB,IRF1,ITGB7,MYC,NT5E,PGF,PKN1,PROM1,SDC4,STAR | 448 (22) |
| valsartan | NA | chemical drug | NA | -1.23e+00 | 2.0e-02 | AGT,FGF2,LEP,MRC1,PPARG,SERPINE1,SLC12A3 | NA |
| IL7 | -2.70e-01 | cytokine | NA | -1.23e+00 | 0.0e+00 | BCL2,BCL2L1,CBLB,CCL4,CD8A,CDKN1A,CFLAR,CISH,FLT3LG,FOXO1,ITGB7,JAK3,MYC,RGS16,SMAD7,TCF3,UPP1 | 445 (21) |
| everolimus | NA | chemical drug | NA | -1.24e+00 | 0.0e+00 | AXIN2,BCL2L1,CCND1,CDKN1A,FSCN1,KDR,MYC | 394 (20) |
| cycloheximide | NA | chemical reagent | NA | -1.25e+00 | 0.0e+00 | AGTR1,BCL2L1,BIRC3,BRAF,BTG2,CCL4,CCND1,CD38,CD8A,CDKN1A,CEBPD,CFLAR,CXCL10,CYP2B6,DDIT4,FGF2,GADD45A,GADD45G,HSD11B1,HSD11B2,IGFBP4,IL1R2,IL1RN,IRS2,JUN,KCND3,LEP,Mt1,MYC,NFKBIA,NR3C1,PPARG,RBM3,RELB,SAMHD1,SERPINE1,STAR,THBS1,TOB1,TRAF1,VDR,VIP | 396 (16) |
| NR4A1 | -4.00e-02 | ligand-dependent nuclear receptor | NA | -1.25e+00 | 0.0e+00 | ACLY,ATP6V1E2,AXIN2,BCL2,CCND1,ELK3,HCAR1,HDC,HK2,KCNIP3,LEP,Mt1,NFKBIA,NT5E,NUCB2,PDK4,PHKG1,PPARG,RAP1GAP2,RASSF4,SAT1,SERPINE1,SMAD7,SREBF1,STAR | 387 (24) |
| SB-431542 | NA | chemical reagent | NA | -1.25e+00 | 1.0e-02 | CCND1,GAL,IL1R2,ITGA11,KCNJ8,LOX,MYC,SERPINE1,SMAD7,SPSB1,SQLE,STAR,TFRC,XYLT1 | 371 (20) |
| TAF4 | NA | transcription regulator | NA | -1.25e+00 | 0.0e+00 | ABL2,BCL2L1,BRAF,CCND1,IL1RN,KLF4,MAFF,MAFK,MAP3K6,PENK,Tchh,THBS1 | 279 (13) |
| TCF7L1 | 2.20e-01 | transcription regulator | NA | -1.25e+00 | 2.0e-02 | AXIN2,EN1,JUN,KLF4,PPARG,SOX17,TBX3 | NA |
| INCB054329 | NA | chemical drug | NA | -1.26e+00 | 0.0e+00 | CCND1,FGFR3,IL6R,MYC | 223 (9) |
| EPCAM | 9.00e-02 | other | NA | -1.26e+00 | 1.0e-02 | CCND1,CDKN1A,FHL2,IRF1,JUN,MYC | NA |
| HAVCR1 | NA | other | NA | -1.26e+00 | 0.0e+00 | FGFR3,FSCN1,HK2,IL1R2,IL6R,IRF1,JUN,NAMPT,NFKBIA,NR3C1,NUCKS1,POMK,RELB,TAP1 | 286 (11) |
| ARID1A | -1.80e-01 | transcription regulator | NA | -1.26e+00 | 1.0e-02 | AXIN2,BCL2,CD83,CDKN1A,CITED1,COL7A1,FMN2,FSCN1,GNA15,IRS2,KCNT2,KLF4,MAIP1,P4HA1,PLXND1,SUN2,TCF7L2,WNT5A,ZFPM2 | NA |
| 26s Proteasome | NA | complex | NA | -1.26e+00 | 1.0e-02 | ATG7,BIRC3,CDKN1A,CFLAR,FOXO1,HSPB8,MYC,NFKB2,Pmaip1,SKIL,STAT5A,TGM2,TRAF4 | NA |
| lithium chloride | NA | chemical drug | NA | -1.26e+00 | 3.0e-02 | ACLY,AXIN2,BCL2,CCND1,CDKN1A,FDPS,FSCN1,MTHFR,MYC,PER1,PPARG | NA |
| ETV5 | 1.00e-02 | transcription regulator | NA | -1.26e+00 | 3.0e-02 | CCND1,CDKN1A,CSF3,LGALS3,MET,NFKBIA,RAB27A,SAMHD1,SELENOS,TINAGL1 | NA |
| tazemetostat | NA | chemical drug | NA | -1.27e+00 | 2.0e-02 | ADAMTS1,AMOT,APEX1,CCND1,CFLAR,EFNB1,FGF2,FLRT3,GATA6,KCNMB4,KLF4,LOX,LRIG1,MET,MYC,NFATC1,NUCKS1,PLK2,RAB3A,SGK1,SLC7A1,TYRO3 | NA |
| SLC16A2 | -2.00e-01 | transporter | NA | -1.28e+00 | 1.0e-02 | CIRBP,HR,RBM3,SLC16A1,SLC7A5,SLC7A8 | NA |
| PML | -6.80e-01 | transcription regulator | NA | -1.28e+00 | 0.0e+00 | ACACB,CCND1,CDKN1A,CIAPIN1,CXCL11,FTL,GADD45A,GPAM,IFI44L,LEP,MAFF,NDRG1,NR3C1,OAS2,PDK4,PIK3C2A,PIK3CB,PML,SREBF1,TAP1 | 406 (24) |
| caffeine | NA | chemical drug | NA | -1.29e+00 | 1.0e-02 | BCL2,CDKN1A,EPAS1,HSD11B2,MITF,PPARG,SREBF1,THBS1 | NA |
| USP22 | 2.80e-01 | peptidase | NA | -1.30e+00 | 1.0e-02 | ACLY,CDKN1A,CIDEC,CSF2RB,CSF3R,IL2RB,MERTK,MRC1,PPARG,TGM2 | 366 (21) |
| fulvestrant | NA | chemical drug | NA | -1.31e+00 | 0.0e+00 | ATF4,BCL2,BLM,BMPR2,CA12,CBS/LOC102724560,CCND1,CDKN1A,CDKN2C,CEBPD,CXCL10,CXCL11,DDIT4,GAB2,GADD45A,GAL,INHBB,IRF1,IRS1,JUN,MYC,NRP1,PLK2,PPARG,ROCK2,SLC7A5,STAR,TFRC,WEE1 | 443 (21) |
| IGF1R | -2.00e-01 | transmembrane receptor | NA | -1.31e+00 | 4.0e-02 | BCL2,BCL2L1,CCND1,CD300C,CD38,CDKN1A,IGFBP4,INHBB,IRS1,IRS2,MYC,PDLIM2,PROM1,RBM3,RPL9,S100A10,SDC4,SREBF1,STAR,TPO | NA |
| SNCA | 3.30e-01 | enzyme | NA | -1.32e+00 | 0.0e+00 | ADRA1A,AGT,ANKRD55,BCL2L1,BHLHE40,CA12,CD22,CHL1,FAM107A,GADD45A,GBP2,GBP5,GRIP2,Ifi47,IFRD1,IRF1,JPH2,KCNG1,KLF4,LHFPL2,MARK1,NECAB1,NRP2,PRF1,PTPRB,RAB3A,RGMA,RPRML,SERPINE1,SGMS1,SPAG8,STX1B,TLR2,WEE1,WIPF3 | 373 (16) |
| lipoteichoic acid | NA | chemical - endogenous non-mammalian | NA | -1.32e+00 | 1.0e-02 | AGTR1,BCL2,BCL2L1,CD83,CSF3,CXCL10,IL1RN,TLR2 | NA |
| NFKB1 | -1.40e-01 | transcription regulator | NA | -1.32e+00 | 0.0e+00 | ADORA1,BCL2,BCL2L1,BHLHE40,BIRC3,BTG2,CCL4,CCND1,CD83,CDKN1A,CRP,CSF3,CX3CL1,CXCL10,CXCL11,EPAS1,FSCN1,GADD45A,HAS2,HOOK2,IKBKE,IL1RN,IRF1,KCNT2,Madcam1,MYC,NAMPT,NFATC1,NFKB2,NFKBIA,RELB,SDC4,TLR2,TRAF1 | 360 (12) |
| NS-398 | NA | chemical reagent | NA | -1.33e+00 | 2.0e-02 | BCL2,BTG2,CCND1,CDKN1A,FGF2,GATA6,PPARG,STAR,TFRC,XRCC6 | NA |
| ECSIT | -2.00e-02 | transcription regulator | NA | -1.33e+00 | 0.0e+00 | CD83,CFLAR,IL1RN,NFKB2,NFKBIA,RELB,STAT5A,TRAF1 | 230 (11) |
| FAS | -2.60e-01 | transmembrane receptor | NA | -1.34e+00 | 0.0e+00 | APPBP2,ARL4A,BCL2,BCL2L1,BIRC3,CCL4,CD22,CD300C,CD83,CDC42EP2,CDKN1A,CEBPD,CFLAR,CXCL10,CXCL11,FADD,FGL2,FOXO1,FOXO3,FSCN1,GADD45G,GBP2,IMPA2,IRF1,JUN,LGALS3,MERTK,MET,NFKBIA,NR3C1,PIK3C2B,PIK3CG,PLD2,PSTPIP1,SERPINE1,SIPA1,SKIL,TFRC,TLR2,TNK2,TRIB1,TYK2,ZFP36 | 339 (14) |
| EGLN | NA | group | NA | -1.34e+00 | 5.0e-02 | ANKRD9,APLN,BNIP3,BRWD3,CSRP2,EGLN3,FTL,GREM2,HK2,PPP1R3G,SERPINE1,SH2B2 | NA |
| mannose | NA | chemical - endogenous mammalian | NA | -1.34e+00 | 0.0e+00 | ATF4,BCL2L1,HAS2,NR3C1,THBS1 | 476 (26) |
| HOXB13 | NA | transcription regulator | NA | -1.34e+00 | 1.0e-02 | CCND1,CDKN1A,EPHA4,MYC,NFKBIA | 147 (7) |
| TRADD | -1.60e-01 | other | NA | -1.34e+00 | 1.0e-02 | CX3CL1,CXCL11,IRF1,NFKBIA,TRAF1 | 216 (12) |
| conjugated linoleic acid | NA | chemical drug | NA | -1.34e+00 | 1.0e-02 | BCL2L1,CBS/LOC102724560,IL1RN,LEP,NFATC1,PPARG,RXRB | NA |
| OSCAR | 1.30e-01 | other | NA | -1.34e+00 | 1.0e-02 | BCL2,CCL24,CD83,CX3CR1,IL1RN | NA |
| MEX3A | -6.20e-01 | other | NA | -1.34e+00 | 3.0e-02 | CCND1,CIDEC,NRP1,PDK4,PPARG | NA |
| ASXL1 | 4.40e-01 | transcription regulator | NA | -1.34e+00 | 3.0e-02 | GPCPD1,HK2,HSD11B1,PPARG,SERPINE1 | NA |
| docosahexaenoic acid | NA | chemical drug | NA | -1.34e+00 | 0.0e+00 | ATF4,BACH1,BCL2,BCL2L1,CCL4,CD83,CDKN1A,FOXO1,FOXO3,HK2,HPGD,LEP,LOX,MRC1,MYC,PPARG,SERPINE1,SMAD7,SPHK1,SREBF1,THBS1 | 423 (21) |
| ZFP36 | 8.20e-01 | transcription regulator | NA | -1.34e+00 | 2.0e-02 | BIRC3,CDKN1A,IRF1,JUN,NFKBIA,NHSL2,TFRC,TRAF1,ZFP36 | NA |
| CCN5 | NA | growth factor | NA | -1.35e+00 | 0.0e+00 | AXIN2,CCND1,JUN,KLF4,PPARG,SDC4,SERPINE1,ZNF423 | 386 (20) |
| MMP2 | 9.00e-02 | peptidase | NA | -1.35e+00 | 0.0e+00 | BCL2L1,CCND1,CDKN1A,CSF2RB,CX3CL1,IL1RN,MYC,PDK4,TYK2 | 386 (16) |
| MED1 | 2.50e-01 | transcription regulator | NA | -1.35e+00 | 0.0e+00 | ACACB,ACLY,ADCY5,BCL2L1,BHLHE40,CCND1,CDKN1A,CYP2B6,DYSF,FOXO1,GADD45A,GPAM,HAS2,HECW2,IL2RB,KLF4,MET,MPP7,MYC,NFKBIA,NR3C1,OTUB2,PDK4,PPARG,PRR5L,SYNPO2,TBX3,THBS1,VDR | 420 (20) |
| KLF5 | 0.00e+00 | transcription regulator | NA | -1.36e+00 | 0.0e+00 | BCL2L1,CCND1,CDKN1A,CEBPD,CGREF1,CSRNP1,EPAS1,JUN,MAFF,MYC,NFKBIZ,PPARD,PPARG,PREB,SMAD7,TBC1D14 | 355 (19) |
| bisindolylmaleimide I | NA | chemical drug | NA | -1.37e+00 | 0.0e+00 | AGT,BCL2,BCL2L1,BIRC3,CDKN1A,FGF2,HAS2,MET,Mt1,NFKBIA,PITPNB,SERPINE1,TRAF1 | 311 (18) |
| ITGB1 | 4.50e-01 | transmembrane receptor | NA | -1.37e+00 | 0.0e+00 | ADAM19,BCL2,CCL4,CDKN1A,COL7A1,CXCL10,FGFR3,FOXO1,FOXO3,GBP2,GDF5,HAS3,IL1RN,ITGA1,ITGB7,JUN,LOX,MMP15,MYC,SERPINE1,TCF7L2,TGM2,THBS1,WNT5A | 387 (19) |
| mir-204 | NA | microRNA | NA | -1.39e+00 | 0.0e+00 | ACVR1,ATF4,BCL2,MYC,NOG,PTPN11,SNAP25,STX1A | 142 (7) |
| ABT-737 | NA | chemical drug | NA | -1.39e+00 | 1.0e-02 | BCL2L1,CDKN1A,GADD45A,IRF1 | NA |
| GJA1 | 1.10e-01 | transporter | NA | -1.39e+00 | 3.0e-02 | CCND1,CDKN1A,FGFR3,FOXO1,THBS1 | NA |
| histone deacetylase | NA | complex | NA | -1.39e+00 | 3.0e-02 | BCL2,CCND1,PER1,SLC7A8,THBS1 | NA |
| CASP1 | -9.00e-02 | peptidase | NA | -1.40e+00 | 4.0e-02 | CSF3,IL22RA2,KDR,PPARG,SREBF1 | NA |
| IRF5 | -2.70e-01 | transcription regulator | NA | -1.41e+00 | 0.0e+00 | BCL2L1,CCL4,CDKN1A,CXCL10,CXCL11,DHX58,FOXO1,MYC,NAMPT,OAS2,Oasl2 | 362 (19) |
| verteporfin | NA | chemical drug | NA | -1.41e+00 | 2.0e-02 | CDKN1A,GADD45A,NFKBIA,NT5E,RANBP1 | NA |
| GH1 | NA | growth factor | NA | -1.41e+00 | 0.0e+00 | ACVR1,ADRB3,ATF4,BCL2,CEBPD,CISH,GADD45A,ITGA1,JUN,SREBF1,STAR,UBA7,XRCC6,ZFP36 | 396 (19) |
| Mt1 | 2.90e+00 | other | NA | -1.41e+00 | 0.0e+00 | CCND1,JUN,LEP,Mt1,MYC,NFKBIA,SERPINE1 | 383 (18) |
| triptolide | NA | chemical drug | NA | -1.43e+00 | 0.0e+00 | APLN,APLNR,BCL2,BCL2L1,CD38,CDKN1A,EDNRB,HK2,HPGD,ITGA1,JUN,KDR,MYC,TLR2 | 333 (22) |
| etoposide | NA | chemical drug | NA | -1.43e+00 | 0.0e+00 | BATF2,BCL2,BCL2L1,BIRC3,BLM,CCND1,CDKN1A,CFLAR,CROCC,CSF2RB,CXCL10,CXCL11,DDIT4,FANCA,FANCG,GADD45A,GADD45G,GBP2,HK2,IFI44L,IL2RB,IRF1,JUN,LIMA1,MERTK,MYC,NFKB2,OAS2,PIDD1,Pmaip1,PRF1,RELB,SGK1,SPHK1,UBA7,XRCC2 | 314 (16) |
| losartan potassium | NA | chemical drug | NA | -1.43e+00 | 3.0e-02 | AGT,AGTR1,APLN,ATF4,CXCL10,EDNRA,GBP2,Ifi47,NR3C2,SERPINE1,STAR,TMEM26 | NA |
| LEF1 | -5.20e-01 | transcription regulator | NA | -1.43e+00 | 0.0e+00 | ARHGAP20,AXIN2,BCL2,BMPR2,C3orf70,CARD11,CCL4,CCND1,CD83,CDKN1A,CEBPD,CSF3R,CX3CR1,EN1,FGF10,HAS2,ITSN1,LONRF1,LRIG1,MITF,MYC,NHSL2,PENK,PILRB,PIP5K1B,Pmaip1,PRF1,PTPRO,RASGEF1B,RNF8,SGK1,TLR2,TSC22D1,USP27X,ZNF467 | 407 (22) |
| wortmannin | NA | chemical drug | NA | -1.43e+00 | 0.0e+00 | AGT,AGTR1,BCL2,BCL2L1,CCL4,CCND1,CDKN1A,CEBPD,CFLAR,CIDEC,CRP,CX3CL1,CXCL10,HAS2,IRF1,IRS1,IRS2,JUN,LEP,MYC,NFKBIA,NT5E,P4HA1,PPARD,RCC1,SERPINE1,SREBF1,TFRC | 439 (22) |
| JUP | -1.80e-01 | other | NA | -1.43e+00 | 0.0e+00 | AXIN2,BCL2,MYC,PML,RNF8 | 355 (13) |
| NCOA4 | 4.10e-01 | transcription regulator | NA | -1.43e+00 | 1.0e-02 | FGFR2,FGFR3,FTL,NR3C1,ST3GAL6 | NA |
| SU6656 | NA | chemical toxicant | NA | -1.43e+00 | 2.0e-02 | CCND1,Mt1,MYC,NFIL3,UCK1 | NA |
| PIK3R1 | 3.70e-01 | kinase | NA | -1.45e+00 | 0.0e+00 | ATF4,BCL2,BCL2L1,CCL4,CCND1,CXCL10,FOXO1,MITF,MYC,PIK3CB,PPARG,SERPINE1 | 424 (21) |
| IL12 (complex) | NA | complex | NA | -1.45e+00 | 4.0e-02 | BCL2L1,CCL4,CD244,CISH,CXCL10,CXCL11,FGF2,GADD45G,IRF1,ITGAL,JUN,MYC,PRF1,TFRC,TLR2 | NA |
| SB 216763 | NA | chemical drug | NA | -1.45e+00 | 1.0e-02 | AXIN2,BHLHE40,CCND1,FSCN1,MYC,RND3,SREBF1 | 427 (21) |
| IL36G | NA | cytokine | NA | -1.47e+00 | 1.0e-02 | CD83,CSF3,CXCL10,MRC1,WNT5A | 329 (14) |
| IFNAR1 | -1.00e-01 | transmembrane receptor | NA | -1.47e+00 | 0.0e+00 | CCL24,CCL4,CXCL10,CXCL11,GBP4,IRF1,MYC,OAS2,Oasl2,SERPINE1,SMAD7,SQLE,TGM2,THBS1,TLR2 | 382 (15) |
| arginine | NA | chemical - endogenous mammalian | NA | -1.47e+00 | 0.0e+00 | AGTR1,ATF4,BCL2,BCL2L1,CXCL10,DDIT4,HDC,MYC,SLC7A5 | 399 (20) |
| IRF1 | -6.40e-01 | transcription regulator | NA | -1.48e+00 | 0.0e+00 | BCL2,CCND1,CDKN1A,CXCL10,CXCL11,FADD,FGL2,GATA6,GBP2,GBP4,IFI44L,Ifi47,IRF1,MYC,OAS2,PML,SAMHD1,TAP1,TBX3 | 332 (16) |
| BAX | -1.50e-01 | transporter | NA | -1.48e+00 | 3.0e-02 | BCL2,CDKN1A,CXCL10,EDEM1,TGM2,TYK2 | NA |
| azoxymethane | NA | chemical toxicant | NA | -1.49e+00 | 0.0e+00 | AGT,AGTR1,BCL2,BLM,CCL4,CCND1,CDKN1A,CXCL10,IL22RA2,MYC | 326 (14) |
| HMGB2 | NA | transcription regulator | NA | -1.50e+00 | 1.0e-02 | ADRB3,CCND1,CSF3,IRS1,LEP,PPARG | 452 (23) |
| FADD | -7.40e-01 | other | NA | -1.51e+00 | 0.0e+00 | BIRC3,CDKN1A,CXCL10,DHX58,FADD,JUN,KLF6,MYC,NFIL3,PARP11,TIPARP | 318 (21) |
| OGA | NA | enzyme | NA | -1.51e+00 | 0.0e+00 | ADAM19,ADGRG2,APOBEC1,BACH1,BCL2,BCL2L1,BRAF,CCND1,CDKN1A,CDKN2C,CIAPIN1,CMTM8,CREB3L2,CSF2RB,CX3CR1,CYP2B6,EFNB1,EPHA4,FDPS,FGFR4,FSCN1,GADD45A,GADD45G,GDF11,GLUL,GPR34,GPT2,HIGD1A,HPGD,IGFBP4,IL6R,ITGB7,JUN,LEP,LRIG1,MYO10,NDUFA5,PHKA2,PRF1,PROM1,RAB27A,RASA3,THBS1 | 431 (26) |
| KMT2D | -1.00e-01 | transcription regulator | NA | -1.52e+00 | 1.0e-02 | ADCY5,ADGRG2,BVES,FBXL7,HOXC6,IRF1,IRF6,KLF4,NT5E,PARP11,PPARG,PPP1R26,TOX3,TRPV2,WDSUB1,ZNF184,ZNF23 | NA |
| Pam3-Cys | NA | chemical toxicant | NA | -1.52e+00 | 2.0e-02 | CD83,CXCL10,IL1RN,SERPINE1,TLR2,TRAF6 | NA |
| NME1 | 1.20e-01 | kinase | NA | -1.54e+00 | 1.0e-02 | BCL2,CCND1,CDKN1A,MET,SERPINE1,SMAD7 | NA |
| IL18 | 2.60e-01 | cytokine | NA | -1.55e+00 | 0.0e+00 | ADAM19,BCL2,BCL2L1,CCL4,CD244,CD83,CFLAR,CX3CR1,CXCL10,CXCL11,DDIT4,EDNRB,GADD45G,GNA15,IL22RA2,IRF1,ITGAL,JUN,MMP15,NFIL3,NFKBIZ,PENK,PRF1,SAMHD1,SLC3A2 | 389 (16) |
| L-methionine | NA | chemical - endogenous mammalian | NA | -1.57e+00 | 1.0e-02 | AGTR1,ATF4,BTG1,CDKN2C,DDIT4,IGFBP4,NFKBIA,SMAD7 | 294 (18) |
| ALOX15 | -5.20e-01 | enzyme | NA | -1.59e+00 | 1.0e-02 | AXIN2,BCL2,CCL4,JUN,PPARD,PPARG | 395 (23) |
| melatonin | NA | chemical - endogenous mammalian | NA | -1.60e+00 | 1.0e-02 | BCL2,BCL2L1,CDKN1A,CRY1,CXCL10,ECE1,HPGD,IL2RB,IRS1,IRS2,LEP,Mt1,MYC,NR3C1,TRAF6 | 428 (22) |
| cardiotoxin | NA | chemical - other | NA | -1.60e+00 | 0.0e+00 | APLN,CCL24,CCL4,CCND1,CD180,CSF2RB,CSF3R,CX3CL1,CXCL10,EDNRB,FGF11,FGF2,GDF11,GMNN,IL1RN,IL6R,ITGA1,ITGB7,LTB4R,MERTK,MMP15,MRC1,NAMPT,PLAGL1,RANBP1,SERPINE1,THBS1,TPO,TSC22D1 | NA |
| SALL4 | 1.50e-01 | transcription regulator | NA | -1.60e+00 | 1.0e-02 | BTG2,CCL4,CCND1,CHEK2,FBXO15,GJA5,JUN,MAPK6,MITF,NFATC1,RND3,SEMA6A,SERPINE1,SMURF1,WNT5A | NA |
| CDKN2A | NA | transcription regulator | NA | -1.61e+00 | 0.0e+00 | AMD1,BACH2,BCL2,BLM,BTG2,CCL24,CCL4,CCND1,CDKN1A,CDKN2C,CEBPD,CRP,CX3CL1,CXCL10,DCK,FANCA,FGF11,FHL2,FMN2,GADD45G,GLUL,GNL3,GPT2,HUNK,IL1R2,IL6R,JUN,LGALS3,MET,MRC1,MYC,NFKB2,NPAT,NR3C1,PGF,PLAGL1,PML,PPFIBP1,RAB27A,RORA,SERPINE1,SOX17,SREBF1,TOB1,TP53INP1,ZBTB16 | 410 (19) |
| RIPK2 | -1.00e-02 | kinase | NA | -1.62e+00 | 0.0e+00 | CXCL10,DHX58,GBP4,IFI44L,IKBKE,MAP3K6,MYC,NFKB2,NFKBIA,OAS2,PPARD,RALGDS,SAMHD1,SREBF1,TRAF1,TRIM14 | 380 (17) |
| miR-155-5p (miRNAs w/seed UAAUGCU) | NA | mature microRNA | NA | -1.62e+00 | 0.0e+00 | AGTR1,BACH1,CCL4,CCND1,FADD,FGD4,FOXO3,IKBKE,JARID2,MET,MOSPD2,MYO10,MYO1E,NT5E,PICALM,PLXND1,SERPINE1,TP53INP1,WEE1 | 192 (7) |
| miR-142-3p (and other miRNAs w/seed GUAGUGU) | NA | mature microRNA | NA | -1.63e+00 | 0.0e+00 | BCL2L1,BCLAF1,BMPR2,C9orf72,ROCK2,SMAD7 | NA |
| TLN1 | 2.10e-01 | other | NA | -1.63e+00 | 0.0e+00 | BCL2,CCL4,CXCL10,GBP2,ITGA1,ITGAL | 246 (14) |
| MRGPRX3 | -8.20e-01 | G-protein coupled receptor | NA | -1.63e+00 | 1.0e-02 | CCL4,CSF3,CSF3R,CXCL10,IL1RN,KCTD11 | NA |
| pembrolizumab | NA | biologic drug | NA | -1.63e+00 | 1.0e-02 | CCL4,CD83,CD8A,CMKLR1,IRF1,PRF1 | NA |
| FKBP10 | 2.10e-01 | enzyme | NA | -1.63e+00 | 5.0e-02 | APLN,C1QTNF1,COL12A1,CRISPLD2,SERPINE1,SPHK1 | NA |
| Hbb-b1 | NA | transporter | NA | -1.63e+00 | 5.0e-02 | CXCL10,EGLN3,FTL,IL2RB,Mt1,NDUFA5,TFRC,TLR2 | NA |
| TLR3 | -2.30e-01 | transmembrane receptor | NA | -1.64e+00 | 0.0e+00 | BCAR3,CCL4,CD38,CFLAR,CSF3,CX3CL1,CXCL10,CXCL11,DHX58,FLT3LG,GBP2,GBP4,IFI44L,Ifi47,IL1R2,IL1RN,IRF1,LPIN2,NFKBIZ,Oasl2,PLK2,SERPINE1,ZNFX1 | 326 (15) |
| EOMES | -1.10e-01 | transcription regulator | NA | -1.64e+00 | 0.0e+00 | AFAP1,APLNR,BCL2,FZD8,IL2RB,ITGA1,KDR,NRP2,PRF1,RND3,SATB2,SOX17 | NA |
| Ifn gamma | NA | complex | NA | -1.65e+00 | 1.0e-02 | AGT,BCL2L1,CDKN1A,CXCL10,IFI44L,IGFBP4,MYC,NR3C1,PML,PPARG | 371 (18) |
| EBF1 | -4.90e-01 | transcription regulator | NA | -1.65e+00 | 0.0e+00 | ACACB,CBLB,CCL24,CD244,CXCL10,CXCL17,FOXO1,HK2,IRF1,IRS1,MKNK1,MYC,NFIL3,PDE3B,PHKA2,PHKG1,PPARG,SREBF1,TCF3,TLR2 | 357 (21) |
| COMMD1 | 1.50e-01 | transporter | NA | -1.66e+00 | 0.0e+00 | ATP7B,BIRC3,BNIP3,DDIT4,EGLN3,HK2,NFKBIA,TFRC | 269 (7) |
| ACE2 | 6.20e-01 | peptidase | NA | -1.66e+00 | 1.0e-02 | AGT,BNIP3,CXCL10,MAS1,SERPINE1,SMAD7 | 327 (15) |
| LTA | -1.40e-01 | cytokine | NA | -1.67e+00 | 0.0e+00 | CRP,HAS2,HDC,JUN,LYVE1,Madcam1,NFKB2,RELB | 389 (17) |
| mir-181 | NA | microRNA | NA | -1.68e+00 | 1.0e-02 | BCL2,CDKN1A,CYLD,GATA6,GRIA2,KLF6,PTPN11,SMAD7,TGM2 | 333 (14) |
| PP1 | NA | chemical drug | NA | -1.71e+00 | 1.0e-02 | BCL2L1,IL1RN,JUN,MYC,SERPINE1,SIRPA | 387 (20) |
| PDPK1 | 3.80e-01 | kinase | NA | -1.71e+00 | 0.0e+00 | BCL2,CCND1,CDKN1A,CXCL10,FOXO1,FOXO3,MYC,PROM1,SERPINE1 | 412 (23) |
| UBR5 | NA | enzyme | NA | -1.71e+00 | 4.0e-02 | CCND1,CDKN1A,CXCL10,IRF1,NRP1,OAS2 | NA |
| SKI | -2.70e-01 | transcription regulator | NA | -1.73e+00 | 2.0e-02 | CDKN1A,MITF,SERPINE1,SMAD7 | NA |
| STS | 7.00e-02 | enzyme | NA | -1.73e+00 | 4.0e-02 | CEBPD,IRS1,Mt1,PPARG | NA |
| TBX21 | -5.40e-01 | transcription regulator | NA | -1.74e+00 | 2.0e-02 | CCL4,CD244,CD38,CX3CR1,CXCL10,IL2RB,IL6R,PRF1 | NA |
| CXCL2 | 7.00e-02 | cytokine | NA | -1.74e+00 | 0.0e+00 | ACE2,BCL2,CCL4,CXCL10,IFRD1,TMPRSS2 | 290 (12) |
| mir-17 | NA | microRNA | NA | -1.74e+00 | 2.0e-02 | ARID4B,BIRC3,CCND1,CDKN1A,CYLD,MAP3K5,TAX1BP1,THBS1,TP53INP1 | NA |
| CAT | 8.00e-02 | enzyme | NA | -1.75e+00 | 4.0e-02 | AGT,ATG7,CDKN1A,CFLAR,SERPINE1,THBS1 | NA |
| IKZF3 | -3.70e-01 | transcription regulator | NA | -1.76e+00 | 0.0e+00 | BCL2,BCL2L1,CD38,KLF4,LHFPL2,MYC,NFKBIZ,OTUD1,RASSF4,SPSB1 | 214 (11) |
| minocycline | NA | chemical drug | NA | -1.77e+00 | 5.0e-02 | AGTR1,BCL2,BCL2L1,IL6R,RGMA,SLC16A1,SLC3A2 | NA |
| mir-122 | 4.00e-02 | microRNA | NA | -1.78e+00 | 2.4e-01 | GALNT10,MARK1,MTHFD2,RBM3,SLC7A1,TGM2 | NA |
| IFNA4 | NA | cytokine | NA | -1.79e+00 | 0.0e+00 | CXCL10,CXCL11,GBP2,GBP5,H2-T22,Irgm1,JAML,MYC,PIK3AP1 | 311 (15) |
| PRL | NA | cytokine | NA | -1.79e+00 | 0.0e+00 | BCL2,BCL2L1,BTG1,CCND1,CDKN1A,CEBPD,CISH,CXCL10,CXCL11,DHX58,DTX3L,HSD11B2,IFI44L,IRF1,ITGA1,JUN,LYVE1,MYC,OAS2,PDE7A,PDK4,PENK,RASD1,RCL1,SAMHD1,STAR,STAT5A,TPH1,TRIM14,TSC22D1,VDR | 447 (19) |
| RGS2 | -1.00e-01 | enzyme | NA | -1.81e+00 | 0.0e+00 | ARHGEF16,BCAR3,BTG2,CEBPD,ERRFI1,HSD11B1,HSD11B2,MFSD2A,PDLIM2,PLXND1,PPARG,PSTPIP1,SLC16A1,SLC7A8,SREBF1 | 329 (12) |
| PTPN11 | 9.50e-01 | phosphatase | NA | -1.83e+00 | 0.0e+00 | BCL2L1,CCND1,CDKN1A,CDKN2C,CSF3R,ENY2,JUN,KDR,MAP3K5,MET,NFATC1,PTPN11,TCF7L2,TP53I11,VIP | 400 (23) |
| IL2 | NA | cytokine | NA | -1.83e+00 | 0.0e+00 | ADAM19,ARHGAP20,BCL2,BCL2L1,BHLHE40,BIRC3,CBLB,CCL4,CCND1,CD244,CD38,CD83,CD8A,CDKN1A,CDKN2C,CFLAR,CISH,CLSPN,CMKLR1,CSF2RB,CSF3,CSRNP1,CX3CR1,CXCL10,CYP2B6,CYSLTR1,CYTH4,DDIT4,DENND2D,EIF2S2,EPAS1,EPHA4,FGF2,FGFR2,FGL2,FLT3LG,FOXO1,FOXO3,GADD45G,GBP2,GNL3,GPR34,HK2,HVCN1,IDH1,IFRD1,IGFBP4,IL1R2,IL1RN,IL2RB,IRF1,ITGA1,ITGB7,JAK3,JAML,JUN,KCNG1,KLF6,LTB4R,MFSD2A,MTHFD2,MYC,MYO1E,NDRG1,NRP1,NT5E,PDE3B,PDE4A,PENK,PIP5K1B,PLAGL1,POLR2D,POLR3K,PPARG,PRF1,RASGEF1B,RGS16,RNF157,SERPINE1,SIPA1,SLC3A2,SLC7A5,SQLE,STAM,TFEB,TFRC,TLR2,TP53INP1,TRAF1,TRAF5,TRAF6,UPP1 | 397 (16) |
| mir-223 | NA | microRNA | NA | -1.84e+00 | 6.0e-02 | APOBEC1,BCL2,CARD11,CCND1,CD180,FGL2,FOXO1,FOXO3,IL1RN,RASGRP4,TOB1 | NA |
| KDM1A | -2.10e-01 | enzyme | NA | -1.84e+00 | 0.0e+00 | ADCY5,AGT,APOBEC1,BLM,CCL4,CD22,CDKN1A,CXCL10,ELL2,ENDOU,FGF10,FGR,FOXO1,GBP2,GBP4,GBP5,HAS3,HSD11B1,HSPB8,IGFBP4,Igtp,IL1RN,Irgm1,Milr1,MYC,Oasl2,PLIN4,PROM1,PTPRB,SERPINE1,SIX5,SMAD7,SNAP25,SREBF1,SYBU,TAP1,THBS1,TLR2 | 413 (24) |
| glutamine | NA | chemical - endogenous mammalian | NA | -1.88e+00 | 0.0e+00 | ATF4,ATG7,CCND1,CDKN1A,DDIT4,GADD45A,IDH1,JUN,KLF4,MYC,NFKB2,NFKBIA,PPP2R2A,PROM1,SLC16A1 | 410 (20) |
| miR-1-3p (and other miRNAs w/seed GGAAUGU) | NA | mature microRNA | NA | -1.88e+00 | 0.0e+00 | BCL2,H3-3A/H3-3B,LIN7C,MET,MOV10,MTHFD2,NRP1,PICALM,RBM28,RBM47,SDC4,SH3PXD2B,SLC25A30,SPHK1,THBS1,TPPP,TRIM2,UST | NA |
| GABA | NA | chemical - endogenous mammalian | NA | -1.88e+00 | 1.8e-01 | ACLY,ADH1C,AMD1,BMPR2,BTG1,COX5A,CREB3L2,CXXC4,EIF2S2,EIF3A,GNL3,HAP1,IDH1,MTHFD2,P4HA1,PIP5K1B,PRDX6,RPP38,RPS18,RXRB,SMAD7,SMURF1,TOB1 | NA |
| N-[N-(3,5-difluorophenacetyl-L-Ala)]-S-phenylglycine t-butyl ester | NA | chemical - protease inhibitor | NA | -1.88e+00 | 0.0e+00 | BCL2,BCL2L1,BMPR2,KDR,LOX,NFKB2,RELB,RND3,SERPINE1,SGK1,SKIL,SMURF1,TBX3,TCF7L2,TRAF6 | 417 (20) |
| CYLD-AS1 | NA | other | NA | -1.89e+00 | 2.0e-02 | FTL,IRF1,LGALS3,NFKB2,NFKBIA,PPARG,PRDX6 | NA |
| Firre | NA | other | NA | -1.89e+00 | 6.0e-02 | BANP,CROCC,MAGEE1,POLD1,RXRB,TCF3,TFEB | NA |
| let-7 | NA | microRNA | NA | -1.90e+00 | 0.0e+00 | BCL2L1,BTG2,CCND1,CEBPD,EDEM1,EIF4A1,GAB2,GMNN,HK2,IL6R,IRS2,ITGA1,LRIG1,MAPK6,MYC,PLAGL1,PROM1,SERPINE1,STAR,THBS1,TMPRSS2,TRIB1,ZFP36 | 340 (19) |
| NONO | -6.00e-02 | transcription regulator | NA | -1.91e+00 | 0.0e+00 | CD38,CXCL10,CXCL11,GBP4,GBP5,IFI44L,IKBKE,OAS2,PDE3B,PDE4A,PDE4D,PDE7A,PI4K2B,PML,SAMHD1 | NA |
| 22(R)-hydroxycholesterol | NA | chemical - endogenous mammalian | NA | -1.91e+00 | 9.0e-02 | HAS2,HAS3,HSD11B1,SREBF1 | NA |
| ZMPSTE24 | 2.00e-02 | peptidase | NA | -1.92e+00 | 0.0e+00 | BTG2,CDKN1A,CISH,DDIT4,FGFR4,FMO2,GADD45A,GADD45G,RGS16,SIRPA | 415 (18) |
| Mt2 | NA | other | NA | -1.93e+00 | 0.0e+00 | CCND1,JUN,LEP,MYC,SERPINE1 | 361 (16) |
| RNASE2 | NA | enzyme | NA | -1.94e+00 | 7.0e-02 | CCL24,CCL4,CD83,CXCL10 | NA |
| stallimycin | NA | biologic drug | NA | -1.95e+00 | 1.4e-01 | CXCL10,GDF5,IRF1,PML | NA |
| N-acetylmuramyl-L-alanyl-D-isoglutamine | NA | chemical - endogenous non-mammalian | NA | -1.95e+00 | 3.5e-01 | AXIN2,CCL4,CXCL11,NFKBIA | NA |
| SCH772984 | NA | chemical drug | NA | -1.96e+00 | 1.0e-02 | ATF4,JUN,MET,RIF1 | NA |
| SERCA | NA | group | NA | -1.96e+00 | 0.0e+00 | BTG2,JUN,MYC,ZFP36 | 348 (16) |
| L-arginine | NA | chemical - endogenous mammalian | NA | -1.96e+00 | 8.0e-02 | AGTR1,BCL2,SERPINE1,TFRC | NA |
| NUMBL | -1.40e-01 | other | NA | -1.97e+00 | 0.0e+00 | CDKN1A,KLF4,MYC,VDR | 178 (9) |
| VCP | 1.90e-01 | enzyme | NA | -1.97e+00 | 1.0e-02 | BCL2,CDKN1A,NFKB2,SMURF1,SUN2 | 392 (19) |
| SMURF2 | 7.00e-02 | enzyme | NA | -1.97e+00 | 1.0e-02 | JUN,SERPINE1,SKIL,SMAD7 | 272 (17) |
| dasatinib | NA | chemical drug | NA | -1.97e+00 | 7.0e-02 | BCL2L1,CDKN1A,CXCL10,SREBF1 | NA |
| CD14 | 8.00e-02 | transmembrane receptor | NA | -1.97e+00 | 2.4e-01 | CCL4,CISH,CXCL10,TLR2 | NA |
| KLF2 | 5.00e-01 | transcription regulator | NA | -1.97e+00 | 0.0e+00 | APLN,APLNR,CCL4,CDKN1A,CRP,CX3CR1,EPAS1,FGR,GADD45A,IL6R,ITGB7,KDR,MAP3K5,MYC,NDRG1,NFKBIA,PGF,PPARG,PRF1,S1PR5,SERPINE1,SREBF1,TFRC,THBS1,TRAF6,WEE1 | 333 (17) |
| pevonedistat | NA | chemical drug | NA | -1.97e+00 | 6.0e-02 | BCL2L1,CFLAR,IRS1,IRS2 | NA |
| DEK | -1.80e-01 | transcription regulator | NA | -1.98e+00 | 0.0e+00 | BIRC3,CDKN1A,CSF3R,NFKBIA,PRDX6 | 255 (8) |
| CD47 | 1.80e-01 | transmembrane receptor | NA | -1.98e+00 | 1.0e-02 | FTL,KDR,MYC,NFATC1,SIRPA | 429 (15) |
| ADAMTS18 | -1.50e-01 | peptidase | NA | -1.98e+00 | 4.0e-02 | CITED1,FGFR2,ITGB7,MMP15 | NA |
| ALDH2 | -5.00e-02 | enzyme | NA | -1.98e+00 | 6.0e-02 | ATF4,MTHFD2,SLC3A2,SLC7A5 | NA |
| crizotinib | NA | chemical drug | NA | -1.98e+00 | 1.1e-01 | BCL2L1,HK2,MITF,SERPINE1 | NA |
| SRSF2 | 3.30e-01 | transcription regulator | NA | -1.98e+00 | 1.1e-01 | ATF4,CCND1,MST1R,SREBF1 | NA |
| imiquimod | NA | chemical drug | NA | -1.98e+00 | 1.5e-01 | A3GALT2,BTG2,CCL4,CSF3,CXCL10,CXCL17,FSCN1,IL1RN,IL6R,MITF,MYC,NFKB2,PNPLA7,UBAC1 | NA |
| PAX7 | -1.00e-02 | transcription regulator | NA | -1.98e+00 | 2.1e-01 | MDFIC,PLAGL1,PPARG,RASA3,TOB1 | NA |
| RIGI | NA | enzyme | NA | -1.99e+00 | 0.0e+00 | BCL2,CCL4,CD83,CX3CR1,CXCL10,CXCL11,IRAK2,IRF1,JAK3,KLF4,MST1R,NFKB2,Pmaip1,RELB,THBS1,UBA7 | 218 (14) |
| ENG | 1.00e-02 | transmembrane receptor | NA | -2.00e+00 | 1.0e-02 | ITGA1,KDR,MYC,SERPINE1,SMAD7,THBS1 | 383 (23) |
| ESRRA | NA | transcription regulator | NA | -2.00e+00 | 0.0e+00 | AGTR1,APLN,APLNR,CRHR2,CSF3,CSRP2,CX3CL1,CX3CR1,CXCL10,DYSF,EPAS1,FRAT2,GRB7,HK2,IGFBP4,KCNJ8,NR1D1,NRP1,NRP2,PDK4,PLK2,PLXND1,PPARG,SEMA6A,ZPBP2 | 332 (14) |
| IFNL4 | NA | cytokine | NA | -2.00e+00 | 0.0e+00 | CXCL10,CXCL11,DHX58,OAS2 | 250 (7) |
| Ptprd | NA | phosphatase | Inhibited | -2.00e+00 | 0.0e+00 | CDKN1A,CEBPD,GADD45G,MYC | 169 (7) |
| SOCS2 | -2.90e-01 | other | Inhibited | -2.00e+00 | 0.0e+00 | CCL4,CD83,CXCL10,PPARG,STAT5A | 350 (18) |
| N-ethyl-N-nitrosourea | NA | chemical toxicant | Inhibited | -2.00e+00 | 1.0e-02 | CCL24,CDKN1A,CRP,CX3CL1,Mt1,OAS2,Oasl2,TGM2 | NA |
| RNY3 | NA | other | Inhibited | -2.00e+00 | 3.0e-02 | BATF2,CXCL10,IFI44L,OAS2 | NA |
| NFIC | -1.90e-01 | transcription regulator | Inhibited | -2.00e+00 | 5.0e-02 | CCND1,CDKN1A,TPO,WNT5A | NA |
| lisinopril | NA | biologic drug | Inhibited | -2.00e+00 | 8.0e-02 | GBP2,Ifi47,JUN,KDR | NA |
| CCL20 | NA | cytokine | Inhibited | -2.00e+00 | 1.1e-01 | CX3CR1,GBP5,IL1RN,PIK3CG | NA |
| CD5 | NA | transmembrane receptor | Inhibited | -2.00e+00 | 2.3e-01 | BCL2,CCL4,RELB,SIPA1 | NA |
| LONP1 | 9.00e-02 | peptidase | Inhibited | -2.00e+00 | 2.6e-01 | ATF4,COX5A,GPT2,MTHFD2,TOMM70 | NA |
| Cdc42 | 1.10e-01 | enzyme | Inhibited | -2.00e+00 | 5.1e-01 | EIF3A,EIF4A1,FADS3,FGF2 | NA |
| AGO2 | 3.00e-02 | translation regulator | Inhibited | -2.00e+00 | 1.0e+00 | CDKN1A,MITF,NFATC1,PDK4 | NA |
| mir-10 | NA | microRNA | Inhibited | -2.00e+00 | 0.0e+00 | ALDH1A3,BCL2L1,BMPR2,CXCL11,EDEM1,FGFR3,FKBP5,FLVCR2,FZD8,GAB2,HDC,IL6R,KLF4,PROM1,PSMD8 | 409 (18) |
| SP2509 | NA | chemical reagent | Inhibited | -2.01e+00 | 5.0e-02 | ADAMTS1,AMOT,CCND1,CFLAR,CXCL10,EFNB1,FGF2,FLRT3,GATA6,KLF4,LOX,MET,MYC,NFATC1,NUCKS1,PLK2,RAB3A,SGK1,SLC7A1,TYRO3 | NA |
| THZ1 | NA | chemical drug | Inhibited | -2.01e+00 | 0.0e+00 | ADAMTSL2,BCL2L1,BIRC3,COL12A1,CSRP2,LGALS3,LOX,MYC,SERPINE1,STAR,THBS1,TRAF1,TRERF1 | 342 (12) |
| poly rI:rC-RNA | NA | biologic drug | Inhibited | -2.01e+00 | 0.0e+00 | AFAP1,ATF4,BATF2,BCL2,BIRC3,BNIP3,CCL4,CCNT1,CD83,CDKN1A,CEBPD,CFLAR,CRP,CSF3,CX3CL1,CXCL10,CXCL11,DDIT4,DHX58,DTX3L,FGF2,GBP2,GBP4,GBP5,GCSAM,IFI44L,Igtp,IKBKE,IL1RN,IRAK2,IRF1,Irgm1,JUN,KLF4,KLF6,LIMK1,MAFF,MERTK,MOV10,MYC,NAMPT,NFIL3,NFKB2,NFKBIA,NFKBIZ,OAS2,Oasl2,PARP11,PML,RAB27A,RASSF4,RELB,SAMHD1,SAT1,SDC4,SERPINE1,SIRPA,SPSB1,SQLE,SSBP3,STAM,STAR,TAP1,TBX3,TCF7L2,THBS1,TIPARP,TLR2,TOMM70,TPO,TRAF1,TRAF6,TRIM14,UBA7,UCKL1,WNT5A,ZFP36 | 394 (13) |
| NCOA3 | -2.00e-01 | transcription regulator | Inhibited | -2.05e+00 | 0.0e+00 | BCL2,CCND1,CDKN1A,CYP2B6,FGF2,FGFR2,HK2,IRF1,IRS1,KDR,NFKBIA,OTUB2,PPARD,PPARG,SREBF1 | 478 (23) |
| tanespimycin | NA | chemical drug | Inhibited | -2.05e+00 | 0.0e+00 | BCL2,BCL2L1,BIRC3,BRAF,CCND1,CDKN1A,CFLAR,EIF4A1,IL6R,JUN,MITF,MYC,SERPINE1,SREBF1 | 417 (23) |
| IL33 | -2.30e-01 | cytokine | Inhibited | -2.05e+00 | 0.0e+00 | ADAMTS1,ALDH1A3,BCL2L1,BIRC3,BNIP3,CCL4,CCND1,CD83,CISH,CSF2RB,CSF3R,CX3CL1,CXCL10,EGLN3,EPAS1,EPHX2,FGL2,FGR,FTL,HDC,IKBKE,IL1RN,IL2RB,KLF4,Milr1,MYC,NFATC1,NFIL3,NFKB2,NFKBIA,NFKBIZ,NR3C1,NRP1,NT5E,P4HA1,PPARG,PREB,RANBP1,RASSF4,RELB,SDC4,SERPINE1,SKIL,SLC7A8,STAT5A,TLR2,TPH1,TRAF1,TRPV2,VMP1,ZFP36 | 345 (13) |
| Interferon alpha | NA | group | Inhibited | -2.10e+00 | 0.0e+00 | ADAM19,ADAMTS1,ANKRD10,BATF2,BCL2,BCL2L1,BTG2,CBLB,CCND1,CD38,CD83,CD8A,CDKN1A,CISH,COL7A1,CSF2RB,CXCL10,CXCL11,DDIT4,DHX58,EDEM1,FMO3,GBP2,GBP5,GNA15,IFI44L,Ifi47,IGFBP4,IKBKE,IL1RN,IL2RB,IL6R,IRF1,ITGA11,LGALS3,MERTK,MTHFD2,MYC,NFIL3,NFKBIA,NT5E,OAS2,Oasl2,PI4K2B,PML,PRF1,SAT1,TAP1,TGM2,TLR2,TRAM2,TRIOBP,TSC22D1,TTC28,UBA7 | 379 (17) |
| ACOX1 | 2.10e-01 | enzyme | Inhibited | -2.11e+00 | 5.0e-02 | ADAMTS1,CDKN1A,GADD45A,HSD11B1,KLF6,LGALS3,PDK4,RBM3,SGK1,SLC16A1,TRPV2 | NA |
| SMAD7 | 6.00e-01 | transcription regulator | Inhibited | -2.11e+00 | 0.0e+00 | ACVR1,ADH1C,BMPR2,CDKN1A,CDKN2C,CFLAR,CGREF1,CRP,CXCL10,FOXO1,GADD45A,MET,MYC,NFKBIA,PROM1,SERPINE1,SMAD7,SOX17 | 351 (21) |
| PXDN | -3.30e-01 | enzyme | Inhibited | -2.12e+00 | 0.0e+00 | CDKN1A,DDIT4,IRS2,JUN,KLF6,LOX,MYC,NFIL3 | NA |
| STEAP3 | -1.00e-01 | transporter | Inhibited | -2.12e+00 | 0.0e+00 | ERRFI1,FGF2,LOX,P4HA1,S100A10,SH3PXD2B,TFRC,TGM2 | NA |
| RARB | -1.80e-01 | ligand-dependent nuclear receptor | Inhibited | -2.12e+00 | 2.4e-01 | ARHGAP4,CDKN1A,GADD45A,GBP2,Ifi47,Igtp,Irgm1,JUN,KLF4,UBA7 | NA |
| IFN type 1 | NA | group | Inhibited | -2.13e+00 | 0.0e+00 | BCL2,BCL2L1,CX3CL1,CXCL10,DHX58,IRF1,PML,UBA7 | 339 (17) |
| Ige | NA | complex | Inhibited | -2.14e+00 | 0.0e+00 | BCL2,BCL2L1,CARD11,CCL24,CCL4,CDKN1A,CISH,CSF3,CX3CL1,ERRFI1,FHL2,HDC,HIP1R,IKBKE,MCF2L,MDFIC,MGST2,MYC,NFATC1,NFKB2,NFKBIA,NRP1,PENK,PIK3CB,PPARG,RAB7B,RALGDS,RELB,RGS16,RILP,ROCK2,SPHK1,STAT5A,TFRC,TLR2,TRAF1,TRAF5,VDR,VMP1 | 386 (16) |
| PLAG1 | -3.90e-01 | transcription regulator | Inhibited | -2.14e+00 | 0.0e+00 | BCL2,CD300C,EFNB1,LILRB3,NFATC1,STX1A,TGM2,TRAF1 | NA |
| let-7a-5p (and other miRNAs w/seed GAGGUAG) | NA | mature microRNA | Inhibited | -2.17e+00 | 5.0e-01 | ADAMTS15,BCL2L1,CCND1,IFRD1,ITGA1,MYC,RPP38,SLC25A32,THBS1 | NA |
| SKIL | 7.90e-01 | transcription regulator | Inhibited | -2.18e+00 | 1.0e-02 | CDKN1A,DIXDC1,SERPINE1,SKIL,SMAD7,SOX17 | NA |
| mir-154 | NA | microRNA | Inhibited | -2.18e+00 | 1.0e-02 | ADAMTS1,BCL2,CCND1,MYC,TRIM2 | NA |
| DACH1 | -3.20e-01 | transcription regulator | Inhibited | -2.20e+00 | 3.0e-02 | CDKN1A,FGF2,JUN,KLF4,SERPINE1 | NA |
| NOD2 | -1.00e-01 | other | Inhibited | -2.20e+00 | 1.1e-01 | AXIN2,CXCL10,NFKB2,NFKBIA,RALGDS,TRAF1 | NA |
| IgG | NA | complex | Inhibited | -2.21e+00 | 0.0e+00 | BCL2,BCL2L1,BHLHE40,BIRC3,CCL4,CD83,CDKN1A,CEBPD,CXCL10,EGLN3,FGL2,FOXO1,IL1R2,IL1RN,IL6R,IRF1,IRS2,ITGAL,LGALS3,MYC,NFKBIA,NT5E,PDE3B,PPARG,RELB,RND3,SDC4,SERPINE1,SGK1,STAT5A,TAP1,THBS1,TOB1,TRAF1,ZFP36 | 407 (17) |
| adavosertib | NA | chemical drug | Inhibited | -2.23e+00 | 0.0e+00 | BCL2,CD83,CX3CR1,CXCL10,CXCL11,DHX58,IRAK2,IRF1,JAK3,MERTK,MST1R,NFKB2,RELB,THBS1 | 368 (13) |
| succinic acid | NA | chemical - endogenous mammalian | Inhibited | -2.24e+00 | 1.0e-02 | ADCY5,AGT,IGFBP4,LEP,SLC16A12 | NA |
| laminaran | NA | chemical drug | Inhibited | -2.24e+00 | 3.0e-02 | CCL4,CXCL10,IFI44L,MAS1,TRAF1 | NA |
| Immunoglobulin | NA | complex | Inhibited | -2.24e+00 | 0.0e+00 | ACLY,ADAM19,ADRA1A,AGT,APLN,APLNR,ATG7,ATP13A2,ATP6V1E2,BCL2,BCL2L1,BIRC3,CBS/LOC102724560,CCL4,CCND1,CD300LF,CD83,CD8A,CEBPD,CHEK2,CISH,CRISPLD2,CSF2RB,CSF3,CX3CR1,CXCL10,CXCL11,CYSLTR1,DDIT4,DYSF,EDNRB,FAM107A,FGFR2,FGL2,FKBP5,FOXO1,FOXO3,GBP5,GLUL,GPR34,GPT2,HK2,HSD11B2,IGFBP4,IL1R2,IL1RN,IL2RB,IMPDH2,IRF1,KDR,KLF4,LGALS3,LILRB3,LOX,LTB4R,MAFF,MERTK,MFSD2A,MMP15,MOV10,MTHFD2,MYC,MYO1E,NAMPT,NFATC1,NFIL3,NFKB2,NFKBIA,NFKBIZ,NOD1,NRP1,NT5E,OAS2,PDE3B,PDK4,PENK,PHKG1,PICALM,PIK3C2A,PLEK,PLIN4,PRF1,PYCARD,RELB,RGS16,SAMHD1,SAT1,SEMA4B,SIRPA,SLC19A1,SLC3A2,SLC6A6,SLC6A9,SLC7A5,SPHK1,SQLE,STAT5A,TCF7L2,TFRC,TLR2,TRAF1,TRAF4,TRAF6,ZBTB16 | 448 (17) |
| Ifn | NA | group | Inhibited | -2.29e+00 | 0.0e+00 | ADAMTS1,CD83,CXCL10,CXCL11,DHX58,IRF1,OAS2,PML,SERPINE1,STAR,TAP1,TFRC,TLR2 | 349 (18) |
| SPI1 | -3.50e-01 | transcription regulator | Inhibited | -2.34e+00 | 3.0e-02 | CCL4,CCND1,CD180,CDKN1A,CSF2RB,CSF3R,CXCL10,CXCL17,FOXO1,IFI44L,IL1R2,IL1RN,JUN,KLF4,LILRB3,MRC1,MYC,NIP7,PIK3CG,PML,TLR2 | NA |
| MDM2 | 3.80e-01 | transcription regulator | Inhibited | -2.36e+00 | 7.0e-02 | BCL2,CCND1,CDKN1A,FOXO3,IL1RN,INHBB,SERPINE1,THBS1 | NA |
| MAVS | -5.40e-01 | other | Inhibited | -2.36e+00 | 0.0e+00 | BCL2,CD83,CX3CR1,CXCL10,CXCL11,DHX58,IRAK2,JAK3,MERTK,MST1R,NFKB2,OAS2,Oasl2,RELB,THBS1 | 237 (15) |
| MXI1 | -2.00e-02 | transcription regulator | Inhibited | -2.37e+00 | 0.0e+00 | APEX1,IMPDH2,IRS2,MTHFD2,MYC,SLC7A1 | NA |
| MITF | -9.90e-01 | transcription regulator | Inhibited | -2.37e+00 | 0.0e+00 | BCL2,CDKN1A,EDNRB,FAM53B,FANCA,FANCG,FGD4,HPGD,IL6R,INPP4B,LGALS3,MET,MITF,NR3C1,POLD1,POLM,PRF1,RAB27A,RAD51D,SEMA6A,SERPINE1,SLC7A8,ST3GAL6,TFEB,TPH1,UPP1 | 322 (14) |
| miR-21-5p (and other miRNAs w/seed AGCUUAU) | NA | mature microRNA | Inhibited | -2.37e+00 | 0.0e+00 | BCL2L1,BMPR2,BTG2,CDKN1A,IL6R,KDR,MITF,SLC16A10,SMAD7 | 302 (15) |
| PARP1 | -1.50e-01 | enzyme | Inhibited | -2.37e+00 | 0.0e+00 | BCL2,CCL4,CCND1,CD83,CDKN1A,CXCL10,ECE1,GBP2,GBP4,HAS2,Igtp,ITGAL,JUN,MITF,MYC,RAPGEF4 | 377 (18) |
| CpG ODN 1826 | NA | chemical reagent | Inhibited | -2.39e+00 | 2.2e-01 | ADRA1A,CCL4,CD83,CXCL10,OAS2,Oasl2 | NA |
| nilotinib | NA | chemical drug | Inhibited | -2.39e+00 | 2.0e-02 | BCL2L1,MYC,ORC2,PTPN11,STAM,WEE1 | NA |
| RBL1 | -1.00e-02 | transcription regulator | Inhibited | -2.41e+00 | 1.2e-01 | CCND1,CDKN1A,FGF2,MET,MYC,THBS1 | NA |
| vitamin E | NA | chemical drug | Inhibited | -2.41e+00 | 3.0e-02 | ALOX12,BCL2,BCL2L1,CDKN1A,KLF6,NFIL3,SERPINE1 | NA |
| trabectedin | NA | chemical drug | Inhibited | -2.43e+00 | 0.0e+00 | CCND1,CDKN1A,CXCL10,GADD45A,PPARG,PRF1,SAT1 | 377 (21) |
| STAT1 | -3.60e-01 | transcription regulator | Inhibited | -2.45e+00 | 0.0e+00 | AGT,ALDH1A3,BATF2,BCL2,BCL2L1,BTG1,CCL4,CCND1,CDKN1A,CEBPD,CSF3R,CX3CL1,CX3CR1,CXCL10,CXCL11,EGLN3,FGF2,FGL2,FOXO1,GBP2,GBP4,GBP5,IFI44L,Ifi47,Igtp,IL1R2,IRF1,Irgm1,JUN,KLF4,MYC,NAMPT,OAS2,Oasl2,Pcsk1,PPARD,PPARG,PRF1,S100A10,SAMHD1,SMAD7,SREBF1,TAP1 | 372 (15) |
| GLI1 | 2.20e-01 | transcription regulator | Inhibited | -2.45e+00 | 0.0e+00 | BCL2,BCL2L1,BIRC3,CA12,CCND1,CDKN1A,CEP70,CSRNP1,DBP,FGF10,FOXO1,GATA6,GREM2,HOXC6,HPGD,HUS1,IL1R2,IMPA2,IRS1,KCNJ8,KLF12,KLF4,KLF6,MAFF,MED13L,MST1R,NOG,OGFRL1,OVOL1,PDK4,PGM2L1,PPT2,PSTPIP2,SAT1,SDC4,SUN2,TBX3,TSC22D1,VMP1,WNT5A,ZFP36 | 351 (14) |
| IFNB1 | 1.90e-01 | cytokine | Inhibited | -2.51e+00 | 0.0e+00 | APOBEC1,BCL2,BCL2L1,BHLHE40,CCL4,CD38,CD83,CDKN1A,COL12A1,CX3CL1,CXCL10,CXCL11,DHX58,FGF2,GBP2,GBP4,GBP5,GLP2R,Ifi47,Igtp,IRF1,Irgm1,MGST2,MYC,NFATC1,NOD1,OAS2,Oasl2,PDK4,PML,RND3,SQLE,THBS1,TRAF6,TRIM14,UBA7,VDR | 330 (14) |
| IFI16 | 1.60e-01 | transcription regulator | Inhibited | -2.52e+00 | 0.0e+00 | ACLY,CCL4,CCND1,CDKN1A,CSF3R,CXCL10,GADD45A,IL1RN,IL2RB,MTHFD2,MYC,NFKBIA | 382 (18) |
| IFNA1/IFNA13 | NA | cytokine | Inhibited | -2.60e+00 | 1.0e-02 | CD83,CXCL10,CXCL11,DHX58,IRF1,MYC,OAS2 | NA |
| MEF2A | 3.00e-02 | transcription regulator | Inhibited | -2.67e+00 | 0.0e+00 | ARHGAP20,CXCL10,GBP2,Ifi47,IRF1,JUN,NOD1,Oasl2,PDE7A,STAR | NA |
| ibrutinib | NA | chemical drug | Inhibited | -2.69e+00 | 0.0e+00 | BCL2,BCL2L1,CCDC71L,COX5A,EPAS1,GNL3,HK2,MAP3K6,MYC,NIP7,RILP,RRP12,SLC19A1,SLC2A5,TTC28 | 307 (21) |
| STING1 | NA | other | Inhibited | -2.72e+00 | 0.0e+00 | BCL2,CCL4,CD83,CX3CR1,CXCL10,CXCL11,GBP4,GBP5,HAP1,HDC,IFI44L,IL22RA2,JAK3,MST1R,NFKB2,RGS16,THBS1,UPP1 | 310 (14) |
| TSC2 | -9.00e-02 | other | Inhibited | -2.73e+00 | 0.0e+00 | ATF4,AXIN2,BCL2,CCND1,CDKN1A,CXCL10,FAM107A,HK2,Ifi47,IRS1,IRS2,LGALS3,Mt1,OGG1,PDK4,PGM2L1,PTPN11,RASSF4,ZFP36 | 395 (24) |
| IFNL1 | NA | cytokine | Inhibited | -2.79e+00 | 0.0e+00 | CD83,CXCL10,CXCL11,GBP5,IFI44L,OAS2,PML,SLC15A3,TLR2,TRIM14 | 365 (13) |
| IRF7 | -5.60e-01 | transcription regulator | Inhibited | -2.79e+00 | 0.0e+00 | ATF4,BCL2L1,CXCL10,DHX58,GBP4,GBP5,IFI44L,Ifi47,Igtp,IRF1,Irgm1,NAMPT,OAS2,Oasl2,TAP1,TRAF1,UBA7 | 253 (16) |
| ITPR2 | 3.70e-01 | ion channel | Inhibited | -2.81e+00 | 1.0e-02 | AFAP1L2,CCL4,CD180,CXCL10,Ifi47,Igtp,Irgm1,PIK3CG | NA |
| Ifnar | NA | group | Inhibited | -2.92e+00 | 3.0e-02 | CD8A,CXCL10,GBP2,IRF1,Irgm1,NOD1,OAS2,TAP1,TLR2 | NA |
| CHROMR | NA | other | Inhibited | -3.00e+00 | 0.0e+00 | BATF2,CDKN1A,CEBPD,CXCL10,CXCL11,DDIT4,DHX58,DTX3L,GBP2,GBP4,GBP5,IFI44L,IL1RN,IRF1,MAFF,MOV10,OAS2,PML,RAB27A,RASSF4,SAMHD1,SERPINE1,SIRPA,SPSB1,SQLE,SSBP3,TBX3,TCF7L2,TRIM14,UBA7 | NA |
| SENP3 | 7.00e-02 | peptidase | Inhibited | -3.00e+00 | 0.0e+00 | CCL4,CD8A,CXCL10,H2-T22,OAS2,Oasl2,PML,SAMHD1,TAP1 | 219 (16) |
| sirolimus | NA | chemical drug | Inhibited | -3.06e+00 | 0.0e+00 | ACACB,ATF4,ATG7,BCL2,BCL2L1,BCORL1,CCND1,CDKN1A,CFLAR,CSF3,CX3CR1,DDIT4,EIF4A1,FGF2,FOXO3,FSCN1,H3-3A/H3-3B,HDAC5,HK2,IDH1,IRS1,IRS2,JUN,KDR,LEP,LGALS3,MED13,MRC1,Mt1,MTHFD2,MYC,NR3C1,PML,PPARD,PPARG,PROM1,PSMD8,RPL9,RPS18,SERPINE1,SKIL,SLC19A1,SLC3A2,SLC6A6,SLC6A9,SLC7A5,SQLE,SREBF1,STAT5A,TP53INP1,VMP1,ZFP36 | 417 (22) |
| GIP | NA | other | Inhibited | -3.12e+00 | 0.0e+00 | ACLY,BCL2,CCL4,CXCL10,GBP2,GBP5,Ifi47,IL1RN,PPARG,SERPINE1 | 441 (24) |
| PD98059 | NA | chemical - kinase inhibitor | Inhibited | -3.18e+00 | 0.0e+00 | AGT,AGTR1,AMD1,ATF4,BATF2,BCL2,BCL2L1,BNIP3,CCL4,CCND1,CD83,CDKN1A,CEBPD,CFLAR,CRP,CXCL10,ECE1,EDNRB,EPAS1,ERRFI1,FAM171A1,FGF2,FKBP5,GADD45A,HAS2,HPGD,HSD11B2,IL1RN,JUN,LEP,MCF2L,MET,MITF,MYC,NFKBIA,PCYT1A,Peg3,PER1,PLAGL1,PPARD,PPARG,S100A10,SERPINE1,SIRPA,SLC3A2,SQLE,SREBF1,STAR,STAT5A,TCF3,TEAD2,THBS1,TLR2,TRAF1,TSC22D1,VAPA,VDR | 443 (20) |
| IRF3 | -4.70e-01 | transcription regulator | Inhibited | -3.22e+00 | 1.0e-02 | BIRC3,CCL4,CX3CL1,CXCL10,DHX58,GBP5,IFI44L,Ifi47,Igtp,IRF1,Irgm1,NR3C1,OAS2,Oasl2,Pmaip1,PML,TAP1 | NA |
| pyridostatin | NA | chemical reagent | Inhibited | -3.29e+00 | 0.0e+00 | BATF2,CXCL10,CXCL11,DHX58,GBP4,IFI44L,IRF1,MOV10,TAP1,TRIM14,UBA7 | 177 (10) |
| IFNA2 | NA | cytokine | Inhibited | -3.34e+00 | 0.0e+00 | BCL2,CDKN1A,CISH,CXCL10,CXCL11,EGLN3,FGF2,GBP2,GBP4,IFI44L,IL2RB,IRF1,MET,MYC,NT5E,OAS2,PML,SAMHD1,SLC15A3,TAP1,TGM2,TRIM14,UBA7 | 362 (16) |
| ZBTB10 | 3.90e-01 | transcription regulator | Inhibited | -3.90e+00 | 0.0e+00 | CCL24,CCL4,CD244,CD83,CD8A,CX3CL1,CXCL10,DHX58,DTX3L,GBP4,GBP5,Ifi47,Igtp,IL1RN,IRF1,Irgm1,NOD1,SAMHD1,SERPINE1,STAT5A | 155 (7) |
| GNA14 | -4.10e-01 | enzyme | NA | NA | 0.0e+00 | ADAMTS1,AGTR1,BNIP3,BTG2,Clec2d (includes others),CX3CL1,GADD45A,GBP2,HAS2,HK2,HSPB8,IL1RN,KLF6,NFIL3,SGK1,SPHK1 | 175 (7) |
| Histone h3 | NA | group | NA | NA | 0.0e+00 | ADCY5,ADRA1A,ANK1,BAHCC1,BCL2,CCND1,CDKN1A,CDKN2C,CFLAR,CXCL10,FGFR2,FKBP5,GATA6,GRIA2,IGFBP4,IL6R,JUN,KDR,LRAT,MEIS2,MET,MITF,Mt1,MYC,NDUFA5,NFKBIA,NHLRC1,NOG,NRARP,PER1,POU2F3,PPARG,SATB2,SEMA6A,SGK1,SLC7A6,SOX17,SPHK1,SREBF1,STAR,STX1A,TBX3,TLR2,TMPRSS2,TRIB1,TYRO3,UPP1,ZNF423 | 393 (20) |
| RBCK1 | -3.60e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CXCL10,CXCL11,FOXO1,GBP4,GBP5,IRF1,MYC,NFKB2,NFKBIA | 326 (15) |
| Sos | NA | group | NA | NA | 0.0e+00 | ALDH1A3,AMIGO1,APLN,BCAR3,HSPB8,IRS2,KLF6,MAFK,MAPK6,MET,MPZL2,NFIL3,PIK3CB,PIP5K1B,PKN1,PLK2,Pmaip1,RANBP9,RGMA,RIPK4,SEMA6D,SIRPA,SMAD7,SMURF1,TIPARP | NA |
| GNA15 | -6.60e-01 | enzyme | NA | NA | 0.0e+00 | ADARB1,Akr1c14,CEBPD,FHL2,FMO1,GADD45A,GBP2,GLUL,IL1RN,LGALS3,MAFK,MGST2,Mt1,MYC,RAPGEF4,SLC6A6,SLC7A1 | 320 (16) |
| SMARCA1 | 0.00e+00 | transcription regulator | NA | NA | 0.0e+00 | CDKN1A,EN1,GADD45A,MYC,STAR | 278 (7) |
| IRAK4 | -2.50e-01 | kinase | NA | NA | 0.0e+00 | BIRC3,BTG2,CSRNP1,CXCL10,ERRFI1,IFRD1,IRF1,JUN,NFKBIA,NFKBIZ,PPARG,RGS16,SLC25A25,ZFP36 | 301 (13) |
| KIT | -4.20e-01 | transmembrane receptor | NA | NA | 0.0e+00 | BCL2,BCL2L1,CISH,CSF2RB,CXCL10,GPR34,HDC,Ifi47,Igtp,IRF1,LGALS3,LTB4R,MGST2,MITF,MYC,PPP2R2A,PSTPIP2 | 402 (21) |
| pituitary adenylate cyclase-activating polypeptide | NA | biologic drug | NA | NA | 0.0e+00 | AXIN2,CCND1,EGLN3,EPHA4,ERRFI1,HRH3,ITGA1,PLK2,SEMA6D,SMIM3 | NA |
| LDLR | -4.00e-02 | transporter | NA | NA | 0.0e+00 | ACLY,ALDH9A1,APOBEC1,AXIN2,BCL2L1,CCL4,CCND1,CDKN1A,CLSPN,CX3CL1,CX3CR1,FDPS,FGL2,GADD45G,GJA5,GPAM,H6PD,HK2,IL1RN,MERTK,MYC,NOD1,PPARG,SREBF1,TAP1,TRIB1 | 404 (21) |
| SMC1A | 1.80e-01 | transporter | NA | NA | 0.0e+00 | BCL2,CSF3R,GATA6,IDH1,KLF4,MYC,PTPN11,SOX17,STAT5A,TINAGL1 | NA |
| AKR1B1 | 3.10e-01 | enzyme | NA | NA | 0.0e+00 | BCL2,BCL2L1,CCND1,CDKN1A,CFLAR,PPARG | 357 (19) |
| STRAP | 1.80e-01 | other | NA | NA | 0.0e+00 | JUN,MYC,SERPINE1 | 311 (23) |
| MAFA | -5.50e-01 | transcription regulator | NA | NA | 0.0e+00 | ALDH1A3,BCL2,CCL24,CDKN1A,CSF2RB,CSF3,CYSLTR1,EGLN3,FGF2,FIGN,FOXO1,GNA15,HTR7,IL2RB,LGALS3,SERPINE1,TBX3,ZNF189 | 197 (7) |
| histidinol | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | ATF4,GPT2,SLC7A1,SLC7A5 | NA |
| IER3 | 1.00e-02 | other | NA | NA | 0.0e+00 | BCL2,BCL2L1,BIRC3,PIK3CB | 296 (14) |
| CP-55940 | NA | chemical reagent | NA | NA | 0.0e+00 | BCL2L1,BCL9,BTG2,CCL4,GADD45A,JUN,MYC,NFKBIA | 352 (20) |
| ADRA1B | 6.40e-01 | G-protein coupled receptor | NA | NA | 0.0e+00 | ADRA1A,ADRA1D,CCND1,CDKN1A,CEBPD,CSRP2,JUN,LEP,LOX | 328 (17) |
| Igm | NA | complex | NA | NA | 0.0e+00 | BCAR3,BCL2,BCL2L1,CD22,CDKN1A,CFLAR,CX3CL1,MYC,NFKB2,TRAF1,TRAF5 | 333 (20) |
| N4 | NA | chemical reagent | NA | NA | 0.0e+00 | BCL2L1,CCND1,MYC | 313 (13) |
| DACT3 | -3.80e-01 | other | NA | NA | 0.0e+00 | AXIN2,CCND1,MYC | 282 (9) |
| danusertib | NA | chemical drug | NA | NA | 0.0e+00 | BCL2L1,CDKN1A,GADD45A | NA |
| miR-515-5p (and other miRNAs w/seed UCUCCAA) | NA | mature microRNA | NA | NA | 0.0e+00 | FGFR2,PIK3C2B,SPHK1 | NA |
| AHNAK | 1.80e-01 | other | NA | NA | 0.0e+00 | CCND1,CDKN1A,MYC | 417 (20) |
| RRM2B | -1.00e-02 | enzyme | NA | NA | 0.0e+00 | CDKN1A,Pmaip1,TP53INP1 | 285 (7) |
| bisindolylmaleimide II | NA | chemical - kinase inhibitor | NA | NA | 0.0e+00 | JUN,PPARG,STAR | 257 (12) |
| PRKAG3 | -5.00e-01 | kinase | NA | NA | 0.0e+00 | ACVR1,AMD1,BTG2,CIDEC,ELL2,FTL,GADD45G,KLF4,LEP,MAGIX,NAMPT,NR3C1,PDE7A,SELENOS,SOX17,SREBF1,TFRC,ZFP36 | NA |
| GFI1B | -2.90e-01 | transcription regulator | NA | NA | 0.0e+00 | ALDH9A1,BCL2L1,CDKN1A,FOXO1,ITSN1,MYC | 147 (6) |
| CSNK1A1 | 1.90e-01 | kinase | NA | NA | 0.0e+00 | AXIN2,CCND1,CDKN1A,MYC | 379 (20) |
| NTRK1 | -2.30e-01 | kinase | NA | NA | 0.0e+00 | BCL2,BCL2L1,CDKN1A,GADD45A,TSC22D1,WNT5A | 313 (21) |
| Igkv1-117 | NA | other | NA | NA | 0.0e+00 | CDKN1A,JUN,MYC,RELB | 294 (19) |
| TCF | NA | group | NA | NA | 0.0e+00 | ADGRG2,ARL4A,BCL2,BCL2L1,CCND1,INHBB,IRS1,ITGA1,LGALS3,MYC,SERPINE1,TSC22D1 | 337 (13) |
| GPD1 | 4.10e-01 | enzyme | NA | NA | 0.0e+00 | ACLY,CCND1,CGREF1,CYP2B6,FADS3,FMO3,GADD45A,GBP4,GPCPD1,MTHFD1L,PI4K2B,PRIMA1 | NA |
| SPINDOC | NA | other | NA | NA | 0.0e+00 | ALDH1A3,C1QTNF1,IFI44L | NA |
| STEAP2 | 4.70e-01 | enzyme | NA | NA | 0.0e+00 | ATF4,PPARG,TFEB | NA |
| RSF1 | 4.90e-01 | transcription regulator | NA | NA | 0.0e+00 | BCL2,BCL2L1,CFLAR | NA |
| EIF3I | 3.30e-01 | translation regulator | NA | NA | 0.0e+00 | CCND1,MYC,SERPINE1 | 265 (7) |
| AZD1480 | NA | chemical drug | NA | NA | 0.0e+00 | CBLB,SLC3A2,SLC7A5 | NA |
| RNF34 | 0.00e+00 | enzyme | NA | NA | 0.0e+00 | BCL2,BCL2L1,CDKN1A | 319 (12) |
| STK17B | 2.00e-01 | kinase | NA | NA | 0.0e+00 | BCL2,BCL2L1,CFLAR | 414 (16) |
| CMP5 | NA | chemical reagent | NA | NA | 0.0e+00 | AXIN2,CCND1,MYC | 229 (11) |
| scoparone | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | BCL2,CCND1,MYC | 169 (7) |
| CBFB-MYH11 | NA | fusion gene/product | NA | NA | 0.0e+00 | GATA6,JUN,SPHK1 | 129 (7) |
| TFDP1 | 0.00e+00 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A,CDKN2C,FGFR2,MYC,PPP1R26,TCF3 | 386 (21) |
| ACVRL1 | -2.30e-01 | kinase | NA | NA | 0.0e+00 | BMPR2,CDKN1A,KDR,LYVE1,MYC,SERPINE1,SMAD7 | 176 (9) |
| SLC25A13 | NA | transporter | NA | NA | 0.0e+00 | ACLY,CCND1,CGREF1,CYP2B6,FADS3,FMO3,GADD45A,GBP4,GPCPD1,MTHFD1L,PI4K2B,PRIMA1 | NA |
| SMARCC1 | 9.00e-02 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A,FOXO3,IRS1,KDR,TCF3 | 257 (7) |
| tetrodotoxin | NA | chemical drug | NA | NA | 0.0e+00 | ADAM19,BACH2,CATSPERG,CNTNAP1,CPNE5,CXXC4,IFRD1,LURAP1L,Mt1,MTHFD1L,MTHFD2,TAP1,TLL1,TMEFF1,TRIM14 | NA |
| OVA-8 | NA | chemical reagent | NA | NA | 0.0e+00 | BCL2L1,CISH,IL2RB,MYC,NFKBIA,NFKBIZ,UTP14A | NA |
| cucurbitacin B | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | BCL2,BCL2L1,CDKN1A,MYC | 285 (16) |
| androstenediol | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | BCL2,CDKN1A,FKBP5,TMPRSS2 | 344 (12) |
| PRKDC | -4.00e-02 | kinase | NA | NA | 0.0e+00 | BIRC3,CCND1,CDKN1A,NR1D1,ROCK2,TMPRSS2 | 440 (21) |
| EPOR | 1.80e-01 | transmembrane receptor | NA | NA | 0.0e+00 | BCL2L1,CISH,JUN,MERTK,MYC,TFRC | 362 (21) |
| CYD0618 | NA | chemical reagent | NA | NA | 0.0e+00 | BCL2,CCND1,MYC | 169 (7) |
| Rp-8-pCPT-cGMPS-triethylamine | NA | chemical reagent | NA | NA | 0.0e+00 | CDKN1A,ROCK2,S100A10 | NA |
| RAB7 | NA | group | NA | NA | 0.0e+00 | CXCL10,MET,MYC | NA |
| MAP4K1 | -2.80e-01 | kinase | NA | NA | 0.0e+00 | BCL2,BCL2L1,BIRC3 | 373 (18) |
| PLSCR1 | 1.20e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,CDKN1A,MYC | 235 (11) |
| Msx3 | -1.00e-02 | transcription regulator | NA | NA | 0.0e+00 | JAK3,MRC1,PPARG | NA |
| BAD | -1.30e-01 | other | NA | NA | 0.0e+00 | BCL2,BCL2L1,CCND1 | 406 (22) |
| OPRK1 | 1.00e-01 | G-protein coupled receptor | NA | NA | 0.0e+00 | KDR,NRP1,PLXND1 | 259 (7) |
| SLC7A11-AS1 | NA | other | NA | NA | 0.0e+00 | CCND1,JUN,MAP3K5 | NA |
| Irs3 | -8.60e-01 | other | NA | NA | 0.0e+00 | IRS2,LEP,SREBF1 | 369 (20) |
| SPIN1 | -2.70e-01 | other | NA | NA | 0.0e+00 | ALDH1A3,C1QTNF1,IFI44L | NA |
| STX2 | -6.50e-01 | transporter | NA | NA | 0.0e+00 | CCND1,MYC,SMAD7 | 438 (22) |
| BTG1 | 6.20e-01 | transcription regulator | NA | NA | 0.0e+00 | BCL2L1,JUN,NR3C1 | 182 (7) |
| CIMO | NA | chemical reagent | NA | NA | 0.0e+00 | BCL2,BCL2L1,CCND1 | 188 (9) |
| trigonelline | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | ACE2,AGT,MAS1 | 146 (7) |
| BCO1 | -1.00e-01 | enzyme | NA | NA | 0.0e+00 | ARRDC3,NR1D1,PPARG,SLC25A30 | NA |
| CRY2 | 1.80e-01 | enzyme | NA | NA | 0.0e+00 | CRY1,DBP,PER1,SGK1 | 109 (7) |
| lonaprisan | NA | chemical drug | NA | NA | 0.0e+00 | CCND1,MYC | 182 (7) |
| CYP4A | NA | group | NA | NA | 0.0e+00 | SGK1,SLC12A3 | NA |
| Rps15a-ps4 | NA | other | NA | NA | 0.0e+00 | NFKB2,NFKBIA | 264 (9) |
| RPRD1B | -5.00e-02 | other | NA | NA | 0.0e+00 | CCND1,MYC | 416 (23) |
| CCDC88C | 2.80e-01 | other | NA | NA | 0.0e+00 | CCND1,MYC | 377 (18) |
| BEST4 | NA | other | NA | NA | 0.0e+00 | CCND1,MYC | 315 (12) |
| CTNNβ-LEF1 | NA | complex | NA | NA | 0.0e+00 | CCND1,MYC | NA |
| voxtalisib | NA | chemical drug | NA | NA | 0.0e+00 | BCL2,TGM2 | 177 (7) |
| NOSIP | 2.00e-02 | other | NA | NA | 0.0e+00 | BCL2,MYC | NA |
| ASNS | 1.50e-01 | enzyme | NA | NA | 0.0e+00 | MYC,SLC7A5 | NA |
| PTPN13 | 1.00e-01 | phosphatase | NA | NA | 0.0e+00 | BCL2L1,MYC | 295 (20) |
| SYCP3 | -2.60e-01 | other | NA | NA | 0.0e+00 | BCL2,BCL2L1 | 181 (7) |
| KLHL40 | -8.30e-01 | other | NA | NA | 0.0e+00 | BNIP3,TP53INP1 | 231 (7) |
| ME1 | 2.70e-01 | enzyme | NA | NA | 0.0e+00 | IRS1,IRS2 | NA |
| Hnrpfl | NA | other | NA | NA | 0.0e+00 | AGT,ELL2 | NA |
| NTSR2 | -2.40e-01 | G-protein coupled receptor | NA | NA | 0.0e+00 | BCL2,BCL2L1 | 289 (15) |
| PDHA1 | 2.40e-01 | enzyme | NA | NA | 0.0e+00 | CCND1,MYC | 139 (7) |
| NEU2 | -4.30e-01 | enzyme | NA | NA | 0.0e+00 | BCL2,BCL2L1 | 378 (17) |
| Gm4836 (includes others) | NA | other | NA | NA | 0.0e+00 | BCL2,BCL2L1 | 181 (7) |
| CRTAP | NA | other | NA | NA | 0.0e+00 | CDKN1A,SERPINE1 | 75 (4) |
| H1f4 | NA | other | NA | NA | 0.0e+00 | AXIN2,MYC | NA |
| ZFYVE16 | 4.00e-02 | other | NA | NA | 0.0e+00 | CDKN1A,SERPINE1 | 329 (12) |
| bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide | NA | chemical reagent | NA | NA | 0.0e+00 | ATF4,GPT2 | NA |
| 3830403N18Rik/Xlr | NA | other | NA | NA | 0.0e+00 | BCL2,BCL2L1 | 181 (7) |
| E. coli 011:B4 lipopolysaccharide | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | BCL2L1,ITSN1 | NA |
| (S)-2-((6Z,15Z)-20- hydroxyicosa-6,15-dienamido)succinate | NA | chemical reagent | NA | NA | 0.0e+00 | AGT,SGK1 | NA |
| castanospermine | NA | chemical reagent | NA | NA | 0.0e+00 | CNTNAP1,TPO | NA |
| HNRNPA2B1 | 2.20e-01 | other | NA | NA | 0.0e+00 | ADGRG2,BCL2L1,CA12,CIDEC,FSCN1,FZD8,INHBB,MEIS2,MFHAS1,MYC,NR3C2,P4HA1,PGM2L1,SNAP25,TOX3 | NA |
| 1,2-dimethylhydrazine | NA | chemical toxicant | NA | NA | 0.0e+00 | ALDH1A3,ALOX12,CCND1,MYC,PER3,PRDX6,TRIM10 | 149 (7) |
| acyline | NA | biologic drug | NA | NA | 0.0e+00 | BCL2,FGFR2,FGFR4,GADD45G,JUN,MYC,RPL9,RPS18,SLC7A1,STAR,TBX3,ZBTB16 | 86 (3) |
| Histone h4 | NA | group | NA | NA | 0.0e+00 | AGT,CCL4,CCND1,CDKN1A,CFLAR,CXCL10,GRIA2,HAS2,IRF1,Mt1,NEURL1,PPARG,SPHK1,SREBF1,STAR | 341 (16) |
| growth factor | NA | group | NA | NA | 0.0e+00 | BCL2,GLUL,MYC,SPHK1 | 394 (23) |
| ZNF521 | -1.80e-01 | transcription regulator | NA | NA | 0.0e+00 | NFATC1,PPARG,ZNF423 | NA |
| mir-329 | NA | microRNA | NA | NA | 0.0e+00 | CCND1,DDIT4,MYC | NA |
| MAEL | NA | transcription regulator | NA | NA | 0.0e+00 | KLF4,MYC,PROM1 | 169 (7) |
| rigosertib | NA | chemical drug | NA | NA | 0.0e+00 | BCL2L1,CCND1,MYC | 394 (19) |
| IL17B | 4.00e-02 | cytokine | NA | NA | 0.0e+00 | BCL2,CDKN1A,CSF3 | 360 (17) |
| GNL1 | -1.80e-01 | other | NA | NA | 0.0e+00 | BCL2,BCL2L1,CDKN1A | 268 (7) |
| SHOX2 | -4.00e-01 | transcription regulator | NA | NA | 0.0e+00 | ADRB3,FGF10,FGFR2 | NA |
| casticin | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | BCL2,BCL2L1,CFLAR | 192 (7) |
| RAPGEF4 | 5.90e-01 | other | NA | NA | 0.0e+00 | CDKN1A,NFATC1,THBS1 | 210 (13) |
| glyceraldehyde-BSA | NA | chemical reagent | NA | NA | 0.0e+00 | CDKN1A,LEP,PPARG | NA |
| methylglyoxal-BSA | NA | chemical reagent | NA | NA | 0.0e+00 | CDKN1A,LEP,PPARG | NA |
| DVL2 | -1.20e-01 | other | NA | NA | 0.0e+00 | AXIN2,MYC,PLXNA2 | 352 (11) |
| CLEC2A | NA | other | NA | NA | 0.0e+00 | BCL2L1,CCL4,CXCL10 | 293 (7) |
| thenoyltrifluoroacetone | NA | chemical reagent | NA | NA | 0.0e+00 | AGT,BIRC3,SERPINE1 | 160 (7) |
| 4-coumaric acid | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CDKN1A,FGF2,MYC | NA |
| gliotoxin | NA | chemical toxicant | NA | NA | 0.0e+00 | BCL2,BCL2L1,BIRC3 | 321 (14) |
| diacerein | NA | chemical drug | NA | NA | 0.0e+00 | BCL2,BCL2L1,IL6R | 330 (20) |
| retroinverso ERG inhibitory peptide 2 | NA | chemical reagent | NA | NA | 0.0e+00 | ADAMTS1,NDRG1,TDRD1 | NA |
| retroinverso ERG inhibitory peptide 1 | NA | chemical reagent | NA | NA | 0.0e+00 | ADAMTS1,NDRG1,TDRD1 | NA |
| D,L-propargylglycine | NA | chemical reagent | NA | NA | 0.0e+00 | AGT,AGTR1,CX3CR1 | NA |
| KCNE3 | -2.00e-02 | ion channel | NA | NA | 0.0e+00 | ACE2,CHL1,CISH,CSRNP1,KLF4,NFIL3,PER1,RDH16,SLC2A5 | NA |
| DYSF | -7.40e-01 | other | NA | NA | 0.0e+00 | ACLY,CD83,CXCL10,ERRFI1,EVI2A,FTL,GDF11,LGALS3,MRC1,SREBF1,TCEAL9 | NA |
| NKX3-1 | -1.00e-02 | transcription regulator | NA | NA | 0.0e+00 | BTG2,CA12,CX3CR1,FKBP5,FOXO3,MYC,SDC4,TMPRSS2 | 296 (11) |
| PC-SPES | NA | chemical drug | NA | NA | 0.0e+00 | ACLY,CCND1,CDKN1A,CDKN2C,DCK,FTL,HMGN3,IRF1,MST1,PRDX6,TMPRSS2 | NA |
| estrone | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | CYP2B6,IRS1,IRS2,SERPINE1 | 437 (22) |
| PADI4 | -6.00e-02 | enzyme | NA | NA | 0.0e+00 | BCL2L1,CDKN1A,GADD45A,PYCARD | 352 (14) |
| SMC3 | -5.00e-02 | other | NA | NA | 0.0e+00 | BMPR2,IRS2,MYC,THBS1 | 8 (2) |
| GHRHR | 1.90e-01 | G-protein coupled receptor | NA | NA | 0.0e+00 | CCND1,CRHR2,HSD11B1,HSD11B2 | 228 (7) |
| SP2 | 1.60e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A,PCYT1A,SERPINE1 | NA |
| NFYB | -1.60e-01 | transcription regulator | NA | NA | 0.0e+00 | ACLY,AMD1,ARID4B,BCL2,BCL2L1,CBS/LOC102724560,CHEK2,CTC1,DCLK3,DTL,EMC6,EPAS1,FGFR2,FLT3LG,GADD45A,GPAM,HMGN3,IGDCC4,KCTD1,OGG1,PAQR5,RIMBP2 | NA |
| GCS-100 | NA | chemical drug | NA | NA | 0.0e+00 | BCL2L1,CDKN1A,LGALS3 | 299 (13) |
| Cyclin A | NA | group | NA | NA | 0.0e+00 | CDKN1A,MYC,PCYT1A | 411 (24) |
| CTNS | -3.70e-01 | transporter | NA | NA | 0.0e+00 | ATF4,RILP,TFEB | NA |
| ZNF382 | -1.00e-01 | transcription regulator | NA | NA | 0.0e+00 | IKBKE,MITF,MYC | NA |
| CXCR1 | 2.30e-01 | G-protein coupled receptor | NA | NA | 0.0e+00 | BCL2,BCL2L1,CCND1 | 355 (21) |
| CYP4A11 | 2.20e-01 | enzyme | NA | NA | 0.0e+00 | AGT,SGK1,SLC12A3 | NA |
| PSMC3IP | -1.40e-01 | transcription regulator | NA | NA | 0.0e+00 | CEBPD,LEP,PPARG | NA |
| WNT7B | -6.00e-02 | other | NA | NA | 0.0e+00 | AXIN2,CCND1,MYC | 390 (16) |
| PIWIL2 | -8.00e-02 | enzyme | NA | NA | 0.0e+00 | BCL2L1,CCND1,CXXC4 | NA |
| SNW1 | 1.80e-01 | transcription regulator | NA | NA | 0.0e+00 | CCND1,CDKN1A,SERPINE1 | 352 (13) |
| LINC01612 | NA | other | NA | NA | 0.0e+00 | BCL2,CDKN1A,MYC | 312 (10) |
| SMARCD1 | 1.30e-01 | transcription regulator | NA | NA | 0.0e+00 | BTG2,CDKN1A,TMPRSS2 | NA |
| DIABLO | NA | other | NA | NA | 0.0e+00 | BIRC3,CDKN1A,CFLAR | 318 (13) |
| proteasome inhibitor | NA | chemical drug | NA | NA | 0.0e+00 | CFLAR,MYC,PPARG | 346 (12) |
| MM-401 | NA | chemical reagent | NA | NA | 0.0e+00 | BCL2,KLF6,MYC | 127 (4) |
| temsirolimus | NA | chemical drug | NA | NA | 0.0e+00 | BCL2L1,CCND1,MYC | 414 (25) |
| GW 5074 | NA | chemical drug | NA | NA | 0.0e+00 | BCL2L1,FGFR2,SERPINE1 | 329 (14) |
| ciclopirox olamine | NA | chemical drug | NA | NA | 0.0e+00 | AXIN2,BCL2L1,CDKN1A | 314 (15) |
| P1,P4-Di(adenosine-5’) tetraphosphate | NA | chemical - endogenous mammalian | NA | NA | 0.0e+00 | NR3C1,THBS1,TPH1 | 156 (5) |
| CBX3 | -2.10e-01 | transcription regulator | NA | NA | 0.0e+00 | BCL2L1,CDKN1A,CYP2B6,HSD11B2,MYC,STAT5A | 373 (12) |
| myricetin | NA | chemical - endogenous non-mammalian | NA | NA | 0.0e+00 | BCL2,CCND1,MYC,SLC16A1 | 391 (24) |
| TAF4B | 2.70e-01 | transcription regulator | NA | NA | 0.0e+00 | INHBB,IRF1,JUN,NFKBIA,ZBTB16 | NA |
| NDUFA13 | 4.00e-01 | enzyme | NA | NA | 1.0e-02 | BCL2,BCL2L1,CCND1,STAR | 239 (13) |
| HBP1 | 1.70e-01 | transcription regulator | NA | NA | 1.0e-02 | CCL24,CCND1,CDKN1A,PDK4 | 404 (22) |
| Smad2/3 | NA | group | NA | NA | 1.0e-02 | ACVR1,CDKN1A,ETV6,SERPINE1,SKIL,SMAD7,SOX17,TGM2,TMEFF1 | NA |
| GY1-22 | NA | chemical reagent | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| thioguanine | NA | chemical drug | NA | NA | 1.0e-02 | BNIP3,MYC | NA |
| mineralocorticoid | NA | chemical drug | NA | NA | 1.0e-02 | APLN,SGK1 | NA |
| DPTIP | NA | chemical reagent | NA | NA | 1.0e-02 | CX3CL1,CXCL10 | NA |
| LLL12B | NA | chemical reagent | NA | NA | 1.0e-02 | CCND1,MYC | 169 (7) |
| TFIIH | NA | complex | NA | NA | 1.0e-02 | CDKN1A,PPARG | 310 (14) |
| sethoxydim | NA | chemical toxicant | NA | NA | 1.0e-02 | BCL2,MYC | NA |
| BBS1 | 1.60e-01 | other | NA | NA | 1.0e-02 | ADRA1A,ADRA1D | NA |
| ZNF276 | -2.60e-01 | transcription regulator | NA | NA | 1.0e-02 | CCND1,MYC | NA |
| LZTS2 | -3.00e-01 | other | NA | NA | 1.0e-02 | MYC,TCF3 | 265 (7) |
| NIBAN2 | NA | transcription regulator | NA | NA | 1.0e-02 | CCND1,MYC | 335 (12) |
| Snhg5 | NA | other | NA | NA | 1.0e-02 | EPAS1,KLF4 | NA |
| H1-3 | NA | other | NA | NA | 1.0e-02 | AXIN2,MYC | NA |
| ZNF451 | 2.30e-01 | enzyme | NA | NA | 1.0e-02 | CDKN1A,SERPINE1 | NA |
| RNF32-DT | NA | other | NA | NA | 1.0e-02 | CCND1,MYC | 265 (7) |
| KLHL2 | -1.10e-01 | other | NA | NA | 1.0e-02 | CCND1,JUN | 279 (7) |
| DSTYK | 0.00e+00 | kinase | NA | NA | 1.0e-02 | CCND1,MYC | 265 (7) |
| KLHL21 | -4.90e-01 | enzyme | NA | NA | 1.0e-02 | NFKBIA,NFKBIZ | NA |
| OLA1 | 2.90e-01 | enzyme | NA | NA | 1.0e-02 | CCND1,CDKN1A | 268 (7) |
| GW 9508 | NA | chemical reagent | NA | NA | 1.0e-02 | CXCL10,NFATC1 | NA |
| CSNK1E | -1.00e-01 | kinase | NA | NA | 1.0e-02 | PER1,SERPINE1 | NA |
| SRGAP1 | -7.00e-02 | other | NA | NA | 1.0e-02 | CCND1,MYC | NA |
| GPC3 | 2.00e-02 | other | NA | NA | 1.0e-02 | CCND1,MYC | 375 (15) |
| ELL | 8.00e-02 | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,MYC | 312 (14) |
| SDCBP2-AS1 | NA | other | NA | NA | 1.0e-02 | CCND1,MYC | 265 (7) |
| U2AF2 | -3.00e-02 | other | NA | NA | 1.0e-02 | CCND1,CDKN1A | 197 (10) |
| BPTF | -9.00e-02 | transcription regulator | NA | NA | 1.0e-02 | EN1,MYC | NA |
| MADD | -2.40e-01 | other | NA | NA | 1.0e-02 | MLPH,RAB27A | NA |
| miR-424-3p (miRNAs w/seed AAAACGU) | NA | mature microRNA | NA | NA | 1.0e-02 | LGALS3,WEE1 | NA |
| miR-153-3p (miRNAs w/seed UGCAUAG) | NA | mature microRNA | NA | NA | 1.0e-02 | BCL2,FOXO1 | NA |
| SGI 1776 | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,MYC | 268 (8) |
| COL7A1 | 7.70e-01 | other | NA | NA | 1.0e-02 | THBS1,WNT5A | NA |
| EIF2B1 | 4.10e-01 | translation regulator | NA | NA | 1.0e-02 | ATF4,CCND1 | NA |
| FTMT | NA | enzyme | NA | NA | 1.0e-02 | FTL,TFRC | NA |
| KIF23 | -9.00e-02 | other | NA | NA | 1.0e-02 | CCND1,MYC | NA |
| SIVA1 | 3.00e-02 | other | NA | NA | 1.0e-02 | BCL2L1,CFLAR | 160 (7) |
| PGD | NA | enzyme | NA | NA | 1.0e-02 | SLC3A2,TFRC | NA |
| PAGR1 | NA | other | NA | NA | 1.0e-02 | CEBPD,NR3C1 | 352 (12) |
| MAP1S | -1.80e-01 | enzyme | NA | NA | 1.0e-02 | BCL2,BCL2L1 | NA |
| AP2A2 | 8.00e-02 | transporter | NA | NA | 1.0e-02 | BCL2,CDKN1A | 52 (3) |
| RASSF7 | 4.60e-01 | other | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| ERCC6 | -5.00e-02 | transcription regulator | NA | NA | 1.0e-02 | LGALS3,OGG1 | NA |
| ATAD2 | -1.30e-01 | enzyme | NA | NA | 1.0e-02 | CCND1,MYC | 271 (7) |
| (E)-1-(2-nitrovinyl)naphthalene | NA | chemical reagent | NA | NA | 1.0e-02 | CCND1,MYC | 255 (8) |
| (E)-9-(2-nitrovinyl)anthracene | NA | chemical reagent | NA | NA | 1.0e-02 | CCND1,MYC | 255 (8) |
| 2,2-dimethylbutyric acid | NA | chemical drug | NA | NA | 1.0e-02 | CISH,MYC | NA |
| S-efavirenz | NA | chemical drug | NA | NA | 1.0e-02 | CYP2B6,SREBF1 | 175 (5) |
| 10-decarbamoylmitomycin C | NA | chemical toxicant | NA | NA | 1.0e-02 | CDKN1A,GADD45A | NA |
| idronoxil | NA | chemical drug | NA | NA | 1.0e-02 | CDKN1A,CFLAR | NA |
| ACTG1-MITF | NA | fusion gene/product | NA | NA | 1.0e-02 | APEX1,MET | NA |
| 3,4-methylenedioxyamphetamine | NA | chemical drug | NA | NA | 1.0e-02 | BCL2L1,JUN | NA |
| mizoribine | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,SGK1 | NA |
| SLC9A3 | 4.80e-01 | ion channel | NA | NA | 1.0e-02 | CCND1,Ifi47,Igtp,Mt1,UPP1 | 293 (7) |
| 3-deazaadenosine | NA | chemical reagent | NA | NA | 1.0e-02 | BCL2L1,CDKN1A,CYLD | 322 (18) |
| tannic acid | NA | chemical toxicant | NA | NA | 1.0e-02 | AGTR1,BCL2,PPARG | 349 (14) |
| berbamine | NA | chemical reagent | NA | NA | 1.0e-02 | BCL2L1,NFKBIA,PDLIM2 | 223 (12) |
| SETD1A | NA | ion channel | NA | NA | 1.0e-02 | CCND1,MYC,PROM1 | 368 (20) |
| MEMO1 | 2.60e-01 | other | NA | NA | 1.0e-02 | CCND1,JUN,MYC | 403 (21) |
| TENM1 | NA | transmembrane receptor | NA | NA | 1.0e-02 | CHL1,EDNRB,SEMA6A | NA |
| PNU282987 | NA | chemical reagent | NA | NA | 1.0e-02 | IRS2,PPARD,SREBF1 | NA |
| ZIC2 | 4.00e-02 | transcription regulator | NA | NA | 1.0e-02 | AXIN2,CCND1,EPHA4 | 205 (7) |
| miR-455-3p (miRNAs w/seed CAGUCCA) | NA | mature microRNA | NA | NA | 1.0e-02 | CCND1,EPAS1,MYC | 204 (7) |
| MED15 | 1.60e-01 | transcription regulator | NA | NA | 1.0e-02 | CCND1,CDKN1A,LIMA1 | NA |
| ABCC4 | -1.60e-01 | transporter | NA | NA | 1.0e-02 | CYP2B6,PDE4A,STAR | NA |
| GPR183 | 6.00e-02 | G-protein coupled receptor | NA | NA | 1.0e-02 | BCL2,BCL2L1,MYC | 285 (10) |
| YBX3 | 2.00e-01 | transcription regulator | NA | NA | 1.0e-02 | CCND1,JUN,MYC | NA |
| TKT | 3.00e-01 | enzyme | NA | NA | 1.0e-02 | BCL2L1,CCND1,LEP | 169 (7) |
| USP17L2 (includes others) | NA | peptidase | NA | NA | 1.0e-02 | KLF4,MYC,PROM1 | NA |
| PDYN | -1.00e-02 | transporter | NA | NA | 1.0e-02 | KDR,NRP1,PLXND1 | NA |
| PD 168393 | NA | chemical drug | NA | NA | 1.0e-02 | BCL2,CXCL10,RGS16 | 429 (19) |
| manassantin B | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | CEBPD,PPARG,SREBF1 | NA |
| PAX3 | -2.70e-01 | transcription regulator | NA | NA | 1.0e-02 | BCL2L1,CDKN1A,CRY1,IL6R,IRS1,MCC,MET,MITF,MKNK1,NFKB2,PGF,SREBF1,TAX1BP1,TCF3,TRIM14,TSC22D1,TYRO3 | NA |
| halofuginone | NA | chemical drug | NA | NA | 1.0e-02 | AACS,BHLHE40,CXCL10,EDNRB,FGFR3,LOX,LRAT,PROM1,SCN1B,SMAD7,TGM2,Tsc22d3,TYRO3,WNT5A | 189 (8) |
| NSD2 | -2.40e-01 | enzyme | NA | NA | 1.0e-02 | BCL2,BTG2,GADD45A,ITGB7,JUN,ROCK2 | 285 (7) |
| GPNMB | 4.40e-01 | enzyme | NA | NA | 1.0e-02 | AXIN2,MITF,MYC,NFATC1,NRP1 | 349 (15) |
| CSF2RB | -7.00e-01 | transmembrane receptor | NA | NA | 1.0e-02 | BCL2,BCL2L1,JUN,MYC | 378 (20) |
| p85 (pik3r) | NA | group | NA | NA | 1.0e-02 | BCL2,NDRG1,PIK3CB,PPARG | 401 (20) |
| RPS6KA3 | -1.50e-01 | kinase | NA | NA | 1.0e-02 | FSCN1,GRIA2,LEP,MYC | 433 (21) |
| RAC2 | -5.40e-01 | enzyme | NA | NA | 1.0e-02 | BCL2,BCL2L1,CCL4,CD244,FHL2,GCSAM,TSC22D1 | 408 (22) |
| fluvastatin | NA | chemical drug | NA | NA | 1.0e-02 | BCL2,BCL2L1,CCND1,CDKN1A,CYP2B6,SERPINE1 | 421 (23) |
| POU2F1 | 1.20e-01 | transcription regulator | NA | NA | 1.0e-02 | APEX1,CCND1,CRP,CYP2B6,DDIT4,ELK3,GADD45A,GBP2,HOMER3,IDH1,TMPRSS2,VIP | 355 (10) |
| RNA polymerase II | NA | complex | NA | NA | 1.0e-02 | ATP13A2,BCL2,CA12,CD83,CDKN1A,CHEK2,CISH,GADD45A,GBP2,HAS2,HSD11B2,Ifi47,IL1RN,JUN,KCNJ9,Mt1,MYC,NFKBIA,PPARG,RALGDS,RND3,TAP1 | 367 (18) |
| Arntl-Clock | NA | complex | NA | NA | 1.0e-02 | DBP,NR1D1,PER1 | 29 (3) |
| NQO2 | -7.00e-02 | enzyme | NA | NA | 1.0e-02 | BCL2,CCND1,CFLAR | 368 (22) |
| BCO2 | NA | enzyme | NA | NA | 1.0e-02 | ARRDC3,NR1D1,SLC25A30 | NA |
| PHF21A | -3.50e-01 | other | NA | NA | 1.0e-02 | RAB3A,SNAP25,STX1A | NA |
| nirogacestat | NA | chemical drug | NA | NA | 1.0e-02 | BCL2,BCL2L1,NR3C1 | 301 (12) |
| cercosporin | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | AXIN2,CCND1,MYC | NA |
| PPM1D | 4.80e-01 | phosphatase | NA | NA | 1.0e-02 | BCL2L1,CCND1,CDKN1A | 394 (20) |
| PDGFA | -5.20e-01 | growth factor | NA | NA | 1.0e-02 | FGF10,FGF2,PROM1 | NA |
| mir-503 | NA | microRNA | NA | NA | 1.0e-02 | BCL2,FGF2,SMAD7 | NA |
| PEBP4 | -1.00e-02 | other | NA | NA | 1.0e-02 | BCL2L1,CDKN1A,NFKBIA | 281 (10) |
| SETD7 | -1.40e-01 | enzyme | NA | NA | 1.0e-02 | CCND1,CXCL10,MYC | 409 (26) |
| NEK2 | NA | kinase | NA | NA | 1.0e-02 | BCL2L1,CDKN1A,GADD45A | 285 (7) |
| capivasertib | NA | chemical drug | NA | NA | 1.0e-02 | AXIN2,PROM1,TGM2 | NA |
| mir-3648 | NA | microRNA | NA | NA | 1.0e-02 | FRAT2,JUN,MYC | NA |
| 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone | NA | chemical reagent | NA | NA | 1.0e-02 | CCND1,CDKN1A,GADD45A | 268 (7) |
| gossypol | NA | chemical drug | NA | NA | 1.0e-02 | ATF4,BCL2L1,SAT1 | 285 (7) |
| diazooxonorleucine | NA | chemical drug | NA | NA | 1.0e-02 | AGT,SREBF1,THBS1 | 255 (12) |
| oridonin | NA | chemical drug | NA | NA | 1.0e-02 | BCL2,BCL2L1,CDKN1A,CSF3R | 389 (21) |
| thiazolidinedione | NA | chemical drug | NA | NA | 1.0e-02 | IRS1,IRS2,NFATC1,SPHK1 | 400 (16) |
| POLR2A | 1.00e-02 | enzyme | NA | NA | 1.0e-02 | BCL2L1,CCND1,CDKN1A,MYC,NFKBIA,SGK1,STAR,TMPRSS2 | 306 (11) |
| FOLR1 | -1.20e-01 | transporter | NA | NA | 1.0e-02 | ACVR1,ADH1C,ASPA,BIRC3,GPAM,PIP5K1B,PPARG,SIX5,SLC3A2,ST3GAL6 | NA |
| MBD3 | -5.00e-02 | other | NA | NA | 1.0e-02 | CCND1,DIXDC1,FBXW4,Mt1,MYC,PPARD,PTPN4,TCF3,WNT5A | 287 (11) |
| HBB | 6.00e-02 | transporter | NA | NA | 1.0e-02 | CCL4,CSF3,CXCL10,CYSLTR1,IL1RN,NOD1,NR3C1,OAS2,RELB,SERPINE1 | 390 (16) |
| ACTN4 | 1.60e-01 | transcription regulator | NA | NA | 1.0e-02 | CCND1,MYC,SERPINE1,WNT5A | 413 (20) |
| H2BC17 | -9.00e-02 | other | NA | NA | 1.0e-02 | ADAM19,CCDC112,MEGF9,MYC,PIK3CG | NA |
| bufalin | NA | chemical reagent | NA | NA | 1.0e-02 | BCL2,BCL2L1,CBLB,CCND1,GJA5 | NA |
| CDK2AP1 | 1.40e-01 | other | NA | NA | 1.0e-02 | DIXDC1,FBXW4,MYC,PPARD,TCF3,WNT5A | NA |
| Irp | NA | group | NA | NA | 1.0e-02 | EPAS1,FTL,TFRC | NA |
| UDP | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CCL4,HAS2,SERPINE1 | NA |
| 2-chloro-N(6)cyclopentyladenosine | NA | chemical reagent | NA | NA | 1.0e-02 | BCL2,BCL2L1,SPHK1 | NA |
| L-serine | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | ATF4,CCND1,CDKN1A | NA |
| CEMIP | -1.00e-02 | enzyme | NA | NA | 1.0e-02 | AXIN2,FGFR4,WBP11 | NA |
| TFCP2L1 | 1.00e-01 | transcription regulator | NA | NA | 1.0e-02 | FBXO15,KLF4,SIRPA | NA |
| PRPF19 | -1.00e-02 | enzyme | NA | NA | 1.0e-02 | CDKN1A,GPAM,PLIN4 | NA |
| HUWE1 | NA | transcription regulator | NA | NA | 1.0e-02 | CDKN1A,CDKN2C,MYC | NA |
| SNHG20 | NA | other | NA | NA | 1.0e-02 | CCND1,CDKN1A,MYC | NA |
| PLA2G1B | NA | enzyme | NA | NA | 1.0e-02 | LEP,PPARD,PPARG | NA |
| DAB2IP | 4.60e-01 | other | NA | NA | 1.0e-02 | CDKN1A,EPAS1,MYC | NA |
| mir-320 | 7.00e-02 | microRNA | NA | NA | 1.0e-02 | CCND1,MYC,TFRC | NA |
| WNT5B | -6.20e-01 | other | NA | NA | 1.0e-02 | ATF4,CCND1,SLC7A5 | NA |
| RUVBL2 | -1.30e-01 | transcription regulator | NA | NA | 1.0e-02 | AXIN2,CCND1,CDKN2C | NA |
| SART1 | 1.00e-01 | other | NA | NA | 1.0e-02 | DDIT4,PROM1,SERPINE1 | NA |
| GADD45B | 3.90e-01 | other | NA | NA | 1.0e-02 | BCL2,BCL2L1,CDKN1A | NA |
| TRAF7 | 3.00e-02 | enzyme | NA | NA | 1.0e-02 | CFLAR,JUN,MYC | NA |
| TBC1D1 | 1.00e-01 | other | NA | NA | 1.0e-02 | CIDEC,PLIN4,PPARG | NA |
| JMJD1C | 1.90e-01 | enzyme | NA | NA | 1.0e-02 | CDKN1A,ETV6,NOG | NA |
| COL17A1 | NA | other | NA | NA | 1.0e-02 | AXIN2,TCF7L2,WNT5A | NA |
| Cxcl3 | 4.00e-02 | cytokine | NA | NA | 1.0e-02 | CCL24,CEBPD,PPARG | NA |
| SIAH1 | 2.50e-01 | enzyme | NA | NA | 1.0e-02 | CDKN1A,EGLN3,SMAD7 | NA |
| CYBA | -1.30e-01 | enzyme | NA | NA | 1.0e-02 | CDKN1A,EPAS1,SERPINE1 | NA |
| BP-1-102 | NA | chemical reagent | NA | NA | 1.0e-02 | BCL2L1,IL1RN,NFIL3 | NA |
| acriflavine | NA | chemical toxicant | NA | NA | 1.0e-02 | MYC,NT5E,PTPRB | NA |
| darglitazone | NA | chemical drug | NA | NA | 1.0e-02 | ADRB3,IRS2,LEP | NA |
| clioquinol | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CDKN1A,JUN | NA |
| 7-(4-fluorobenzylamino)-1,3,4,8-tetrahydropyrrolo[4,3,2-de]quinolin-8(1H)-one | NA | chemical reagent | NA | NA | 1.0e-02 | BCL2,CCND1,CHEK2 | NA |
| enterolactone | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CCND1,IL1RN,KDR | NA |
| SS18-SSX2 | NA | fusion gene/product | NA | NA | 1.0e-02 | AXIN2,BCL2,CCND1 | NA |
| PD 180970 | NA | chemical drug | NA | NA | 1.0e-02 | BCL2L1,MYC | NA |
| L-alanine | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| inecalcitol | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| QC6352 | NA | chemical reagent | NA | NA | 1.0e-02 | CXCL10,CXCL11 | NA |
| GPR55 | -2.40e-01 | G-protein coupled receptor | NA | NA | 1.0e-02 | IRS1,PPARG | NA |
| tanshinone I | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | BCL2,MYC | NA |
| NPSR1 | -6.00e-02 | G-protein coupled receptor | NA | NA | 1.0e-02 | GADD45A,MYC | NA |
| CINP | 2.20e-01 | other | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| NDUFB2 | 3.30e-01 | enzyme | NA | NA | 1.0e-02 | CXCL10,CXCL11 | NA |
| SOCS7 | 1.10e-01 | other | NA | NA | 1.0e-02 | IRS1,PPARG | NA |
| DNAJB4 | 5.50e-01 | other | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| BHMT | -2.70e-01 | enzyme | NA | NA | 1.0e-02 | CBS/LOC102724560,SREBF1 | NA |
| PUM1 | -2.60e-01 | other | NA | NA | 1.0e-02 | CDKN1A,GATA6 | NA |
| PLEKHO2 | -2.70e-01 | other | NA | NA | 1.0e-02 | BIRC3,CFLAR | NA |
| WAPL | 3.60e-01 | other | NA | NA | 1.0e-02 | CCND1,MYC | NA |
| ENTPD2 | 5.60e-01 | enzyme | NA | NA | 1.0e-02 | ITGA1,SERPINE1 | NA |
| SLC13A5 | 2.00e-02 | transporter | NA | NA | 1.0e-02 | ACLY,CDKN1A | NA |
| USP35 | -4.80e-01 | peptidase | NA | NA | 1.0e-02 | CCND1,MYC | NA |
| KCTD9 | 4.10e-01 | other | NA | NA | 1.0e-02 | CCND1,MYC | NA |
| enecadin | NA | chemical drug | NA | NA | 1.0e-02 | BCL2,FGF2 | NA |
| RNF43 | -1.17e+00 | enzyme | NA | NA | 1.0e-02 | AXIN2,GLUL | NA |
| MUCL1 | NA | other | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| XRN2 | 1.70e-01 | enzyme | NA | NA | 1.0e-02 | FRAT2,MYC | NA |
| pertuzumab | NA | biologic drug | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| DIO1 | -9.00e-02 | enzyme | NA | NA | 1.0e-02 | HR,SLC16A1 | NA |
| CDC25B | -2.90e-01 | phosphatase | NA | NA | 1.0e-02 | CCND1,MYC | NA |
| MS4A2 | -2.50e-01 | transmembrane receptor | NA | NA | 1.0e-02 | BCL2,BCL2L1 | NA |
| G0S2 | 3.10e-01 | other | NA | NA | 1.0e-02 | MYC,SLC19A1 | NA |
| miR-27a-5p (miRNAs w/seed GGGCUUA) | NA | mature microRNA | NA | NA | 1.0e-02 | CX3CR1,PRF1 | NA |
| beta,beta-dimethylacrylshikonin | NA | chemical reagent | NA | NA | 1.0e-02 | BCL2,BIRC3 | NA |
| LIMK1 | 6.00e-01 | kinase | NA | NA | 1.0e-02 | LIMK1,MYC | NA |
| HAS3 | -1.61e+00 | enzyme | NA | NA | 1.0e-02 | CDKN1A,HAS2 | NA |
| TOP3A | -9.20e-01 | enzyme | NA | NA | 1.0e-02 | BLM,CDKN1A | NA |
| NASP | 4.10e-01 | other | NA | NA | 1.0e-02 | CCND1,CDKN1A | NA |
| PER3 | -7.60e-01 | other | NA | NA | 1.0e-02 | DBP,H6PD | NA |
| SHBG | -7.00e-02 | other | NA | NA | 1.0e-02 | ACLY,PPARG | NA |
| CCKAR | NA | G-protein coupled receptor | NA | NA | 1.0e-02 | LEP,MET | NA |
| SNRK | 1.20e-01 | kinase | NA | NA | 1.0e-02 | CCND1,MYC | NA |
| WARS1 | NA | enzyme | NA | NA | 1.0e-02 | FGF2,NFKBIA | NA |
| S3I-1757 | NA | chemical reagent | NA | NA | 1.0e-02 | BCL2L1,CCND1 | NA |
| COL1A2 | NA | other | NA | NA | 1.0e-02 | CDKN1A,SERPINE1 | NA |
| SLC9A3R2 | 3.20e-01 | transporter | NA | NA | 1.0e-02 | CCND1,MYC | NA |
| LRRC8C | 3.80e-01 | ion channel | NA | NA | 1.0e-02 | PPARG,SREBF1 | NA |
| ceralasertib | NA | chemical drug | NA | NA | 1.0e-02 | BTG2,CDKN1A | NA |
| LY5 | NA | chemical reagent | NA | NA | 1.0e-02 | BCL2L1,CCND1 | NA |
| 1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione | NA | chemical reagent | NA | NA | 1.0e-02 | CEBPD,PPARG | NA |
| abrocitinib | NA | chemical drug | NA | NA | 1.0e-02 | BCL2,MYC | NA |
| SB 204741 | NA | chemical reagent | NA | NA | 1.0e-02 | SEMA6B,TIPARP | NA |
| pyridoxal phosphate | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | BCL2,NR3C1 | NA |
| alpha-methylhydrocinnamic acid | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CISH,MYC | NA |
| 1,5-dihydroxyisoquinoline | NA | chemical reagent | NA | NA | 1.0e-02 | EDNRA,EDNRB | NA |
| chlorophyll a | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | BCL2,PPARG | NA |
| 1,1-diethyl-2-hydroxy-2-nitrosohydrazine | NA | chemical toxicant | NA | NA | 1.0e-02 | GADD45A,NFKBIA | NA |
| CCI-007 | NA | chemical reagent | NA | NA | 1.0e-02 | BCL2,MYC | NA |
| afamelanotide | NA | biologic drug | NA | NA | 1.0e-02 | PPARD,PPARG | NA |
| phosphoramidon | NA | chemical - endogenous non-mammalian | NA | NA | 1.0e-02 | ECE1,EDNRB | NA |
| MVP | 1.10e-01 | other | NA | NA | 1.0e-02 | CD83,JUN,MITF,NFATC1 | NA |
| idarubicin | NA | chemical drug | NA | NA | 1.0e-02 | BCL2,CDKN1A,GADD45A,TP53INP1 | NA |
| MAZ | -4.80e-01 | transcription regulator | NA | NA | 1.0e-02 | CCL24,CDKN1A,CX3CL1,IL1RN,MYC,PPARG | NA |
| PRDM5 | 0.00e+00 | transcription regulator | NA | NA | 1.0e-02 | EDNRA,IL6R,INTS3,MYC,OVOL1,PML,POU2F3,RXRB,TINAGL1 | NA |
| icilin | NA | chemical reagent | NA | NA | 1.0e-02 | CCL4,CSF3,CXCL10 | NA |
| ulipristal acetate | NA | chemical drug | NA | NA | 1.0e-02 | BCL2,BCL2L1,KDR | NA |
| 2,5-bis(5-hydroxymethyl-2-thienyl)furan | NA | chemical reagent | NA | NA | 1.0e-02 | CDKN1A,GADD45A,RNF8 | NA |
| USP28 | -3.70e-01 | peptidase | NA | NA | 1.0e-02 | CCND1,CDKN1A,MYC | NA |
| DEPTOR | 5.40e-01 | other | NA | NA | 1.0e-02 | CX3CL1,CXCL10,CXCL11 | NA |
| BMS-754807 | NA | chemical drug | NA | NA | 1.0e-02 | BCL2,EPHA4,MET | NA |
| CST3 | 1.00e-02 | other | NA | NA | 1.0e-02 | FGF2,NFATC1,NFKBIA | NA |
| SH3KBP1 | 2.30e-01 | other | NA | NA | 1.0e-02 | BCL2L1,MYC,SERPINE1 | NA |
| PRAME | NA | other | NA | NA | 1.0e-02 | BCL2,BCL2L1,CDKN1A | NA |
| DDB2 | -5.50e-01 | other | NA | NA | 1.0e-02 | CDKN1A,CFLAR,NFKBIA | NA |
| EFNB1 | -6.00e-01 | other | NA | NA | 1.0e-02 | BCL2,BCL2L1,CFLAR | NA |
| FSCN1 | -6.40e-01 | other | NA | NA | 1.0e-02 | CXCL10,MITF,THBS1 | NA |
| Col17a1 | -1.60e-01 | other | NA | NA | 1.0e-02 | AXIN2,TCF7L2,WNT5A | NA |
| bisphenol A diglycidyl ether | NA | chemical reagent | NA | NA | 1.0e-02 | EGLN3,SERPINE1,VDR | NA |
| SR 144528 | NA | chemical reagent | NA | NA | 1.0e-02 | CCL4,IL1RN,NFKBIA | NA |
| huaier extract granule | NA | chemical drug | NA | NA | 1.0e-02 | CCND1,DIXDC1,WNT5A | NA |
| putrescine | NA | chemical - endogenous mammalian | NA | NA | 1.0e-02 | CDKN1A,JUN,TLR2 | NA |
| zinostatin | NA | biologic drug | NA | NA | 1.0e-02 | BCL2,CDKN1A,CROCC | NA |
| MAP3K5 | 8.10e-01 | kinase | NA | NA | 1.0e-02 | CCND1,CDKN1A,JUN,MAP3K5 | NA |
| IFNAR2 | -1.10e-01 | transmembrane receptor | NA | NA | 1.0e-02 | CXCL10,CXCL11,GBP4,OAS2,TGM2,UBA7 | NA |
| Rar | NA | group | NA | NA | 1.0e-02 | BCL2,BTG2,CDKN1A,CSF3,TGM2 | NA |
| ZIC3 | NA | transcription regulator | NA | NA | 1.0e-02 | CCL24,CX3CL1,CXCL17,GATA6,SOX17 | NA |
| SMAD1 | -9.00e-02 | transcription regulator | NA | NA | 2.0e-02 | BCL2L1,BTG2,CDKN1A,IRF1,MYC,SMAD7 | NA |
| ETS | NA | group | NA | NA | 2.0e-02 | CCND1,HPGD,JAK3,SERPINE1 | NA |
| CDH2 | -2.30e-01 | other | NA | NA | 2.0e-02 | CCND1,CDKN1A,JUN,NDRG1 | NA |
| IFNK | NA | cytokine | NA | NA | 2.0e-02 | CD83,CXCL10,CXCL11,IRF1 | NA |
| TNFRSF13B | NA | transmembrane receptor | NA | NA | 2.0e-02 | BCL2,BCL2L1,CFLAR,NFKBIA | NA |
| PDGFC | -4.00e-02 | growth factor | NA | NA | 2.0e-02 | CCND1,FGF2,KDR,MYC | NA |
| desipramine | NA | chemical drug | NA | NA | 2.0e-02 | BCL2,CDKN1A,FGF2,PDE4A | NA |
| ladostigil | NA | chemical drug | NA | NA | 2.0e-02 | BCL2,BCL2L1,TFRC | NA |
| KDM4D | -3.90e-01 | enzyme | NA | NA | 2.0e-02 | BCL2,CCND1,CDKN1A | NA |
| FFAR1 | NA | G-protein coupled receptor | NA | NA | 2.0e-02 | IRS2,NFATC1,TFEB | NA |
| TMEM165 | -9.00e-02 | other | NA | NA | 2.0e-02 | BMPR2,NOG,SERPINE1 | NA |
| LECT2 | 1.30e-01 | other | NA | NA | 2.0e-02 | CSF3,CXCL10,PPARG | NA |
| RSPO1 | -1.80e-01 | other | NA | NA | 2.0e-02 | AXIN2,MYC,RNF43 | NA |
| FANCA | 1.53e+00 | other | NA | NA | 2.0e-02 | CDKN1A,FANCG,WNT5A | NA |
| ANG | -1.90e-01 | enzyme | NA | NA | 2.0e-02 | BCL2,CDKN1A,CXCL10 | NA |
| CTNNBIP1 | 3.80e-01 | other | NA | NA | 2.0e-02 | AXIN2,CCND1,CDKN1A | NA |
| SLC7A5 | 2.04e+00 | transporter | NA | NA | 2.0e-02 | ATF4,SLC3A2,SPIRE2 | NA |
| LRAT | -8.00e-01 | enzyme | NA | NA | 2.0e-02 | CDKN1A,PDK4,PPARD | NA |
| TWIST | NA | group | NA | NA | 2.0e-02 | CDKN1A,NRP1,RORA | NA |
| CSF2RA | -1.50e-01 | transmembrane receptor | NA | NA | 2.0e-02 | JUN,MYC,PIK3CG | NA |
| FABP2 | NA | transporter | NA | NA | 2.0e-02 | ACACB,LEP,PPARG | NA |
| PIK3R2 | -3.50e-01 | kinase | NA | NA | 2.0e-02 | BCL2L1,CXCL10,FOXO1 | NA |
| PIM3 | 2.00e-01 | kinase | NA | NA | 2.0e-02 | BCL2L1,CD38,MYC | NA |
| FZR1 | -2.80e-01 | kinase | NA | NA | 2.0e-02 | CCND1,HECW2,RNF157 | NA |
| KRIT1 | 1.40e-01 | other | NA | NA | 2.0e-02 | JUN,KLF4,THBS1 | NA |
| RPL22 | 2.50e-01 | translation regulator | NA | NA | 2.0e-02 | ATF4,CDKN1A,Pmaip1 | NA |
| CRY1 | 7.00e-01 | enzyme | NA | NA | 2.0e-02 | DBP,PER1,SGK1 | NA |
| TRAF1 | -6.80e-01 | other | NA | NA | 2.0e-02 | BCL2L1,NFKB2,TRAF1 | NA |
| 1-chloro-2-(2,2,2-trichloro-1-(4-chlorophenyl)ethyl)benzene | NA | chemical toxicant | NA | NA | 2.0e-02 | CDKN1A,CYP2B6,GADD45A | NA |
| nordihydroguaiaretic acid | NA | chemical drug | NA | NA | 2.0e-02 | BCL2,NFATC1,STAR | NA |
| trehalose | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | BCL2,KDR,NAMPT | NA |
| omeprazole | NA | chemical drug | NA | NA | 2.0e-02 | ADORA1,AGT,BCL2L1,CDKN1A,EPAS1,HDC | NA |
| 1,2-dioctanoyl-sn-glycerol | NA | chemical reagent | NA | NA | 2.0e-02 | JUN,VDR | NA |
| NSC 172285 | NA | chemical reagent | NA | NA | 2.0e-02 | NFKB2,RELB | NA |
| (+)-fluprostenol | NA | chemical drug | NA | NA | 2.0e-02 | FGF2,PPARG | NA |
| L-aspartic acid | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| p38 Sapk | NA | group | NA | NA | 2.0e-02 | CCND1,CD83 | NA |
| ILX-23-7553 | NA | chemical drug | NA | NA | 2.0e-02 | BCL2,CCND1 | NA |
| Mst/krs | NA | group | NA | NA | 2.0e-02 | NFKB2,RELB | NA |
| Integrinα | NA | group | NA | NA | 2.0e-02 | ITGAL,TLR2 | NA |
| Ctnna | NA | group | NA | NA | 2.0e-02 | AXIN2,SOX17 | NA |
| edratide | NA | biologic drug | NA | NA | 2.0e-02 | FOXO3,ITGAL | NA |
| RAR-RXR | NA | complex | NA | NA | 2.0e-02 | IRF1,TGM2 | NA |
| LGALS12 | -4.60e-01 | other | NA | NA | 2.0e-02 | LEP,PPARG | NA |
| ENHO | -1.90e-01 | other | NA | NA | 2.0e-02 | FOXO1,IRS2 | NA |
| DACT1 | -3.00e-01 | other | NA | NA | 2.0e-02 | CCND1,JUN | NA |
| MTF2 | 3.10e-01 | transcription regulator | NA | NA | 2.0e-02 | KLF4,TBX3 | NA |
| BUD23 | NA | enzyme | NA | NA | 2.0e-02 | FKBP5,PLAGL1 | NA |
| C1QL4 | -1.00e-02 | other | NA | NA | 2.0e-02 | PPARG,STAR | NA |
| JADE2 | 1.60e-01 | enzyme | NA | NA | 2.0e-02 | BTG2,TOMM20 | NA |
| ICMT-DT | NA | other | NA | NA | 2.0e-02 | BCL2,FSCN1 | NA |
| Gata | NA | group | NA | NA | 2.0e-02 | KDR,MAFK | NA |
| UTP18 | 5.50e-01 | other | NA | NA | 2.0e-02 | BCL2,MYC | NA |
| SLC39A4 | -7.00e-02 | transporter | NA | NA | 2.0e-02 | CCND1,Mt1 | NA |
| proanthocyanidin derivative | NA | chemical - other | NA | NA | 2.0e-02 | ATG7,JUN | NA |
| PUF60 | 9.00e-02 | other | NA | NA | 2.0e-02 | MYC,XRCC6 | NA |
| ZNF740 | 1.60e-01 | transcription regulator | NA | NA | 2.0e-02 | CCL24,GDF11 | NA |
| MCF2 | 4.00e-02 | other | NA | NA | 2.0e-02 | CCND1,ITGA1 | NA |
| TYMS | -1.10e-01 | enzyme | NA | NA | 2.0e-02 | CDKN1A,MYC | NA |
| miR-136-5p (miRNAs w/seed CUCCAUU) | NA | mature microRNA | NA | NA | 2.0e-02 | BCL2,PDK4 | NA |
| MIR4269 | NA | microRNA | NA | NA | 2.0e-02 | MYC,TEAD1 | NA |
| mir-191 | NA | microRNA | NA | NA | 2.0e-02 | IRS1,TCF3 | NA |
| MIR3662 | NA | microRNA | NA | NA | 2.0e-02 | CCND1,MYC | NA |
| mir-383 | NA | microRNA | NA | NA | 2.0e-02 | GADD45G,MYC | NA |
| RIPK4 | -8.70e-01 | kinase | NA | NA | 2.0e-02 | IRF6,OVOL1 | NA |
| TIMP4 | 6.00e-02 | other | NA | NA | 2.0e-02 | BCL2,BCL2L1 | NA |
| RBM14 | -2.70e-01 | transcription regulator | NA | NA | 2.0e-02 | CCND1,MYC | NA |
| SEPTIN9 | NA | enzyme | NA | NA | 2.0e-02 | ARHGAP4,CCND1 | NA |
| FLOT1 | -4.00e-02 | other | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| PSAP | 0.00e+00 | other | NA | NA | 2.0e-02 | BIRC3,CCND1 | NA |
| BCAR3 | 1.17e+00 | other | NA | NA | 2.0e-02 | CCND1,IRS1 | NA |
| ANKRD1 | 1.00e-02 | transcription regulator | NA | NA | 2.0e-02 | BCL2,BCL2L1 | NA |
| NPR3 | 1.90e-01 | G-protein coupled receptor | NA | NA | 2.0e-02 | PPARG,SLC12A3 | NA |
| RBBP8 | 2.00e-02 | enzyme | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| GNL2 | 5.30e-01 | enzyme | NA | NA | 2.0e-02 | CDKN1A,MYC | NA |
| N-lauroyl-L-phenylalanine | NA | chemical reagent | NA | NA | 2.0e-02 | GADD45G,MARK1 | NA |
| H3B-8800 | NA | chemical drug | NA | NA | 2.0e-02 | CXCL10,CXCL11 | NA |
| silicon phthalocyanine | NA | chemical drug | NA | NA | 2.0e-02 | CCND1,CDKN1A | NA |
| SQ 29548 | NA | chemical reagent | NA | NA | 2.0e-02 | NFATC1,STAR | NA |
| atrasentan | NA | chemical drug | NA | NA | 2.0e-02 | BCL2,BCL2L1 | NA |
| ethyl protocatechuate | NA | chemical reagent | NA | NA | 2.0e-02 | BCL2L1,CDKN1A | NA |
| vanadyl sulfate | NA | chemical reagent | NA | NA | 2.0e-02 | IL1R2,IL1RN | NA |
| IMTPPE | NA | chemical reagent | NA | NA | 2.0e-02 | ELL2,TMPRSS2 | NA |
| CB-PIC | NA | chemical reagent | NA | NA | 2.0e-02 | BCL2,BCL2L1 | NA |
| azelaic acid | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | BCL2,PPARG | NA |
| GDF15 | 3.30e-01 | growth factor | NA | NA | 2.0e-02 | CCND1,CDKN1A,RND3,SERPINE1 | NA |
| PBX1 | -1.40e-01 | transcription regulator | NA | NA | 2.0e-02 | AMD1,CDKN1A,FGF2,NFIL3,TCF7L2 | NA |
| honokiol | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | BCL2L1,CCND1,CDKN1A,KDR,PPARG | NA |
| exisulind | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | CDKN1A,GATA6,SAT1 | NA |
| 4-nonylphenol | NA | chemical toxicant | NA | NA | 2.0e-02 | MYC,SKIL,STAR | NA |
| dihydroartemisinin | NA | chemical drug | NA | NA | 2.0e-02 | CCND1,CDKN1A,MYC | NA |
| doramapimod | NA | chemical drug | NA | NA | 2.0e-02 | CCND1,HAS2,TLR2 | NA |
| UCA1 | NA | other | NA | NA | 2.0e-02 | CCND1,GPT2,SLC7A5 | NA |
| LILRA2 | NA | other | NA | NA | 2.0e-02 | CSF3,MRC1,TYRO3 | NA |
| SAMHD1 | -8.10e-01 | enzyme | NA | NA | 2.0e-02 | NFKB2,NFKBIA,SAMHD1 | NA |
| withaferin A | NA | chemical reagent | NA | NA | 2.0e-02 | CDKN1A,CFLAR,SERPINE1 | NA |
| CSNK2B | 1.40e-01 | kinase | NA | NA | 2.0e-02 | CCND1,CFLAR,MYC | NA |
| VASP | -4.00e-01 | other | NA | NA | 2.0e-02 | CCND1,EPAS1,MYC | NA |
| MYOF | -1.70e-01 | other | NA | NA | 2.0e-02 | KDR,NFATC1,PPARG | NA |
| PIAS4 | -1.40e-01 | transcription regulator | NA | NA | 2.0e-02 | IRF1,PDK4,SERPINE1 | NA |
| PTPRE | 2.40e-01 | phosphatase | NA | NA | 2.0e-02 | MET,STAT5A,TSC22D1 | NA |
| PPP2R2A | 6.30e-01 | phosphatase | NA | NA | 2.0e-02 | CLSPN,CYP2B6,SAT1 | NA |
| TNKS | 1.70e-01 | enzyme | NA | NA | 2.0e-02 | AXIN2,CSF3,MYC | NA |
| thermozymocidin | NA | chemical reagent | NA | NA | 2.0e-02 | BCL2L1,MRC1,PYCARD | NA |
| Cd2+ | NA | chemical toxicant | NA | NA | 2.0e-02 | CCND1,Mt1,MYC | NA |
| diphtheria toxin | NA | chemical - endogenous non-mammalian | NA | NA | 2.0e-02 | ADAM19,COL12A1,DBT,IL1R2,MERTK,NFATC1,PENK,RELB,S100A10,TGM2,Tlr12,TLR2 | NA |
| GNB2 | -5.00e-02 | enzyme | NA | NA | 2.0e-02 | CCL4,CD83,CDKN1A,IL1R2,PLK2 | NA |
| POU2AF1 | -1.00e-02 | transcription regulator | NA | NA | 2.0e-02 | BCL2,BCL2L1,CD83,FGL2,FOXO1,GADD45G,IFI44L,MYC,NFKB2,S100A10,STAT5A | NA |
| CHCHD10 | NA | other | NA | NA | 2.0e-02 | ATF4,MTHFD1L,MTHFD2,MYC | NA |
| E2F5 | 2.10e-01 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A,MYC,RANBP1,SERPINE1 | NA |
| PTBP1 | -4.00e-02 | enzyme | NA | NA | 2.0e-02 | CIRBP,GPT2,MYC,WNT5A | NA |
| UBE3A | 2.00e-01 | enzyme | NA | NA | 2.0e-02 | CDKN1A,PML,SERPINE1,TP53INP1 | NA |
| RNASEH2A | -2.50e-01 | enzyme | NA | NA | 2.0e-02 | CXCL10,GBP2,IRF1,NFKB2,NFKBIA,TLR2 | NA |
| ONECUT1 | NA | transcription regulator | NA | NA | 2.0e-02 | ABL2,ACACB,ACVR1,AGTR1,CEBPD,CIR1,EIF4A1,FADS3,IFT74,IRF6,NFKBIA,PI4K2B,POLR2D,PPARD,PPFIBP1,PTPRR,RORA,SAMHD1,SEMA6A,UTP3 | NA |
| LHCGR | NA | G-protein coupled receptor | NA | NA | 2.0e-02 | ADAMTS1,IGFBP4,IL1R2,INHBB,STAR | NA |
| IGHM | NA | transmembrane receptor | NA | NA | 2.0e-02 | BCL2L1,CD22,JUN,LGALS3,MYC | NA |
| TCF7 | NA | transcription regulator | NA | NA | 2.0e-02 | AXIN2,CEBPD,MET,PPARD,PPARG,RORA | NA |
| CDK1 | 1.60e-01 | kinase | NA | NA | 2.0e-02 | CDKN1A,CXCL10,IL1RN,JUN | NA |
| HSP90AB1 | -5.00e-02 | enzyme | NA | NA | 2.0e-02 | BCL2L1,CFLAR,EPAS1,MYC | NA |
| echinomycin | NA | chemical drug | NA | NA | 2.0e-02 | ADAMTS1,HK2,MST1R | NA |
| PDCD10 | 2.00e-01 | other | NA | NA | 2.0e-02 | KLF4,SERPINE1,THBS1 | NA |
| particulate matter | NA | chemical reagent | NA | NA | 2.0e-02 | ACE2,Pmaip1,TMPRSS2 | NA |
| FOXG1 | -4.00e-02 | transcription regulator | NA | NA | 2.0e-02 | CDKN1A,GDF11,SERPINE1 | NA |
| IGFBP7 | -7.00e-02 | transporter | NA | NA | 2.0e-02 | CCND1,CDKN1A,MYC | NA |
| Betacatenin/TCF | NA | complex | NA | NA | 2.0e-02 | CCND1,JUN,MYC | NA |
| PYY | NA | other | NA | NA | 2.0e-02 | IRS2,LEP,PPARG | NA |
| RXFP2 | 5.20e-01 | G-protein coupled receptor | NA | NA | 2.0e-02 | HR,INHBB,SOX17 | NA |
| miR-96-5p (and other miRNAs w/seed UUGGCAC) | NA | mature microRNA | NA | NA | 2.0e-02 | FOXO1,IRS1,MITF | NA |
| mir-455 | NA | microRNA | NA | NA | 2.0e-02 | CCND1,HK2,MYC | NA |
| miR-135a-5p (and other miRNAs w/seed AUGGCUU) | NA | mature microRNA | NA | NA | 2.0e-02 | NR3C1,NR3C2,PPARG | NA |
| miR-374b-5p (and other miRNAs w/seed UAUAAUA) | NA | mature microRNA | NA | NA | 2.0e-02 | KLF6,NFKBIZ,ZFP36 | NA |
| FERMT2 | 3.00e-02 | other | NA | NA | 2.0e-02 | CCND1,FOXO1,SREBF1 | NA |
| CRKL | NA | kinase | NA | NA | 2.0e-02 | CXCL10,FGL2,HDC | NA |
| GLUL | 8.40e-01 | enzyme | NA | NA | 2.0e-02 | GLUL,MRC1,SLC7A5 | NA |
| OCLN | -9.00e-02 | other | NA | NA | 2.0e-02 | CCL4,CSF3,CXCL10 | NA |
| ACVR1B | -5.00e-02 | kinase | NA | NA | 2.0e-02 | KLF4,SERPINE1,SMAD7 | NA |
| BTC | -4.60e-01 | growth factor | NA | NA | 2.0e-02 | HAS2,IRS2,SREBF1 | NA |
| CAMKK2 | -1.30e-01 | kinase | NA | NA | 2.0e-02 | CCND1,CDKN1A,LEP | NA |
| vadimezan | NA | chemical drug | NA | NA | 2.0e-02 | CXCL10,IRF1,NFKBIA | NA |
| zeranol | NA | chemical - endogenous mammalian | NA | NA | 2.0e-02 | BCL2,BCL2L1,MYC | NA |
| Mn(III)-tetrakis-(4-benzoic acid) porphyrin | NA | chemical reagent | NA | NA | 2.0e-02 | AGT,BCL2,SERPINE1 | NA |
| asiatic acid | NA | chemical reagent | NA | NA | 2.0e-02 | BCL2,CDKN1A,SMAD7 | NA |
| alpha-estradiol | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | CYP2B6,SREBF1 | NA |
| Cobra Venom Factor | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | CRP,FGF2 | NA |
| warburgia ugandensis dimethyl carbonate extract | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | CCND1,FOXO3 | NA |
| repertaxin | NA | chemical drug | NA | NA | 3.0e-02 | ACE2,TMPRSS2 | NA |
| hesperidin | NA | chemical drug | NA | NA | 3.0e-02 | BCL2L1,NR3C1 | NA |
| vanillyl-N-nonylamide | NA | chemical drug | NA | NA | 3.0e-02 | CCND1,GADD45A | NA |
| lupeol | NA | chemical drug | NA | NA | 3.0e-02 | BCL2L1,PROM1 | NA |
| SWI-SNF | NA | complex | NA | NA | 3.0e-02 | MET,PPARG | NA |
| ZMIZ1 | 2.50e-01 | transcription regulator | NA | NA | 3.0e-02 | MYC,SERPINE1 | NA |
| ADGRL2 | 4.00e-02 | G-protein coupled receptor | NA | NA | 3.0e-02 | BCL2,CCND1 | NA |
| DLX6-AS1 | NA | other | NA | NA | 3.0e-02 | CDKN1A,WEE1 | NA |
| RNU1-1 | NA | other | NA | NA | 3.0e-02 | CXCL10,FGF2 | NA |
| RASSF3 | -3.50e-01 | other | NA | NA | 3.0e-02 | BCL2,CDKN1A | NA |
| LINC00472 | NA | other | NA | NA | 3.0e-02 | FGFR2,FOXO3 | NA |
| ANGPTL6 | -6.00e-02 | other | NA | NA | 3.0e-02 | FGF2,LEP | NA |
| AMER1 | -2.40e-01 | other | NA | NA | 3.0e-02 | AXIN2,CDKN1A | NA |
| Crnde | NA | other | NA | NA | 3.0e-02 | CCND1,MYC | NA |
| Integrin alpha 4 beta 1 | NA | complex | NA | NA | 3.0e-02 | BCL2,BCL2L1 | NA |
| VANGL2 | -1.80e-01 | other | NA | NA | 3.0e-02 | PRICKLE2,SDC4 | NA |
| ZNRF3 | NA | enzyme | NA | NA | 3.0e-02 | AXIN2,GLUL | NA |
| PPP1R14B | 0.00e+00 | phosphatase | NA | NA | 3.0e-02 | EPAS1,KDR | NA |
| lumefantrine | NA | chemical drug | NA | NA | 3.0e-02 | BCL2,BCL2L1 | NA |
| PRKACB | 2.30e-01 | kinase | NA | NA | 3.0e-02 | MYC,PENK | NA |
| CD27 | -5.50e-01 | transmembrane receptor | NA | NA | 3.0e-02 | BCL2L1,CXCL10 | NA |
| ZNF207 | 2.70e-01 | transcription regulator | NA | NA | 3.0e-02 | MBNL2,RBM3 | NA |
| HPRT1 | 2.70e-01 | enzyme | NA | NA | 3.0e-02 | EN1,LMX1A | NA |
| LINC01133 | NA | other | NA | NA | 3.0e-02 | AXIN2,CCND1 | NA |
| NEK10 | NA | kinase | NA | NA | 3.0e-02 | CDKN1A,GADD45A | NA |
| BCL2L12 | -1.30e-01 | other | NA | NA | 3.0e-02 | CDKN1A,Pmaip1 | NA |
| mir-637 | NA | microRNA | NA | NA | 3.0e-02 | CCND1,FOXO1 | NA |
| HTR2C | NA | G-protein coupled receptor | NA | NA | 3.0e-02 | LEP,PPARG | NA |
| GNAZ | -3.90e-01 | enzyme | NA | NA | 3.0e-02 | CCL4,CXCL10 | NA |
| MAGED1 | -5.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,JUN | NA |
| RNF111 | 1.00e-01 | enzyme | NA | NA | 3.0e-02 | SERPINE1,SMAD7 | NA |
| SRPK1 | -3.10e-01 | kinase | NA | NA | 3.0e-02 | BCL2L1,CXCL10 | NA |
| FSTL3 | 4.40e-01 | other | NA | NA | 3.0e-02 | ACVR1,CDKN1A | NA |
| COL4A1 | 2.30e-01 | other | NA | NA | 3.0e-02 | BCL2,BCL2L1 | NA |
| ECT2 | -3.90e-01 | other | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| WAC | 9.00e-02 | other | NA | NA | 3.0e-02 | PDK4,PPARG | NA |
| NUCKS1 | 5.80e-01 | kinase | NA | NA | 3.0e-02 | CDKN1A,LEP | NA |
| EEF2K | 5.40e-01 | kinase | NA | NA | 3.0e-02 | BCL2L1,CDKN1A | NA |
| RAP1A | 3.90e-01 | enzyme | NA | NA | 3.0e-02 | CDKN1A,THBS1 | NA |
| HIVEP2 | 2.40e-01 | transcription regulator | NA | NA | 3.0e-02 | MYC,NFATC1 | NA |
| UHRF1 | -1.70e-01 | transcription regulator | NA | NA | 3.0e-02 | KLF6,WNT5A | NA |
| CDH13 | 5.00e-02 | other | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| RPS20 | NA | other | NA | NA | 3.0e-02 | CDKN1A,MYC | NA |
| CLEC4M | -3.10e-01 | other | NA | NA | 3.0e-02 | CCL4,CSF3 | NA |
| OBP2B | NA | transporter | NA | NA | 3.0e-02 | PPARG,SREBF1 | NA |
| OMP-52M51 | NA | biologic drug | NA | NA | 3.0e-02 | MYC,NRARP | NA |
| equol | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | BCL2L1,MYC | NA |
| CXXC4 | -6.60e-01 | other | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| BCL2A1 | -4.10e-01 | other | NA | NA | 3.0e-02 | BCL2,BCL2L1 | NA |
| SET | 5.00e-02 | phosphatase | NA | NA | 3.0e-02 | BCL2L1,CHEK2 | NA |
| LGH447 | NA | chemical drug | NA | NA | 3.0e-02 | MYC,NFATC1 | NA |
| fenebrutinib | NA | chemical drug | NA | NA | 3.0e-02 | BCL2,MYC | NA |
| MIA-459 | NA | chemical reagent | NA | NA | 3.0e-02 | BCL2,NFKB2 | NA |
| MIA-313 | NA | chemical reagent | NA | NA | 3.0e-02 | BCL2,NFKB2 | NA |
| gelam honey | NA | chemical reagent | NA | NA | 3.0e-02 | BCL2L1,NFKBIA | NA |
| coxsackievirus A21 | NA | biologic drug | NA | NA | 3.0e-02 | CXCL10,CXCL11 | NA |
| UCA1 | NA | other | NA | NA | 3.0e-02 | GPT2,SLC7A5 | NA |
| XCT790 | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A,PDK4 | NA |
| ferric nitrilotriacetate | NA | chemical toxicant | NA | NA | 3.0e-02 | BCL2L1,KLF4 | NA |
| etomidate | NA | chemical drug | NA | NA | 3.0e-02 | CISH,NR3C1 | NA |
| pyridoxamine | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | CRP,SERPINE1 | NA |
| butylated hydroxytoluene | NA | chemical toxicant | NA | NA | 3.0e-02 | JUN,VIP | NA |
| avasimibe | NA | chemical drug | NA | NA | 3.0e-02 | CYP2B6,SREBF1 | NA |
| dibenzoylmethane | NA | chemical toxicant | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| gingerenone A | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | CDKN1A,SERPINE1 | NA |
| Z-VRPR-FMK | NA | chemical - protease inhibitor | NA | NA | 3.0e-02 | BCL2L1,CFLAR | NA |
| ruboxistaurin | NA | chemical drug | NA | NA | 3.0e-02 | NR3C2,SREBF1 | NA |
| saquinavir | NA | chemical drug | NA | NA | 3.0e-02 | MYC,NFKBIA | NA |
| EPZ005687 | NA | chemical - protease inhibitor | NA | NA | 3.0e-02 | HSD11B2,MYC | NA |
| GSI34 | NA | chemical reagent | NA | NA | 3.0e-02 | BCL2L1,CCND1 | NA |
| Z-VEID-FMK | NA | chemical reagent | NA | NA | 3.0e-02 | CCND1,SPHK1 | NA |
| sparfosic acid | NA | chemical drug | NA | NA | 3.0e-02 | BCL2,CDKN1A | NA |
| L-asparagine | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| drospirenone | NA | chemical drug | NA | NA | 3.0e-02 | ADRB3,PPARG | NA |
| BMI1 | NA | transcription regulator | NA | NA | 3.0e-02 | BNIP3,BTG2,CDKN1A,HK2,LOX,MET,P4HA1 | NA |
| GSE1 | -1.30e-01 | other | NA | NA | 3.0e-02 | IL1RN,JAML,OSBPL11,PI4K2A,SLC7A5 | NA |
| HSD11B1 | 6.40e-01 | enzyme | NA | NA | 3.0e-02 | AGT,GPAM,LEP,PDK4,SREBF1 | NA |
| GNB1 | 1.10e-01 | enzyme | NA | NA | 3.0e-02 | CCL4,CD83,CDKN1A,IL1R2,PLK2 | NA |
| N-(3-(aminomethyl)benzyl)acetamidine | NA | chemical reagent | NA | NA | 3.0e-02 | BCL2L1,CFLAR,HUS1,TRAF1,TRAF4 | NA |
| discodermolide | NA | chemical drug | NA | NA | 3.0e-02 | BLM,CDKN1A,FANCG,GADD45A,WEE1 | NA |
| BCOR | -4.60e-01 | transcription regulator | NA | NA | 3.0e-02 | ADAMTS1,CDKN1A,ETV6,HOXC6,MYC,NFATC1 | NA |
| advanced glycation end-products | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | BCL2,CDKN1A,FGF2,FOXO1,PPARG,SERPINE1 | NA |
| MTA2 | 4.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,JUN,MYC,SQLE | NA |
| kaempferol | NA | chemical toxicant | NA | NA | 3.0e-02 | BCL2,BCL2L1,CDKN1A,JUN | NA |
| HHEX | -5.20e-01 | transcription regulator | NA | NA | 3.0e-02 | CX3CL1,CXCL10,FGF2,KDR,NRP1 | NA |
| BRAF | 6.20e-01 | kinase | NA | NA | 3.0e-02 | ACVR1,ATF4,BIRC3,CCND1,CDKN1A,EPAS1,FGF2,JUN,MITF,MMP15,MYC,NT5E,POMK,RND3,SERPINE1,SLC7A1,THBS1,TPO,TSC22D1 | NA |
| cyclic GMP | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | BCL2,CDKN1A,SERPINE1 | NA |
| glycerol | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | AGT,NR3C1,PPARG | NA |
| epothilone B | NA | chemical drug | NA | NA | 3.0e-02 | BTG2,CDKN1A,THBS1 | NA |
| salubrinal | NA | chemical reagent | NA | NA | 3.0e-02 | ATF4,NFATC1,SNAP25 | NA |
| LINC00662 | NA | other | NA | NA | 3.0e-02 | CCND1,MRC1,MYC | NA |
| PNPLA1 | 5.00e-02 | enzyme | NA | NA | 3.0e-02 | CYP4F22,ELOVL4,PPARD | NA |
| THRAP3 | 4.60e-01 | transcription regulator | NA | NA | 3.0e-02 | CCND1,HAS2,NR3C1 | NA |
| KLF17 | NA | transcription regulator | NA | NA | 3.0e-02 | CCL24,CDKN1A,IL1RN | NA |
| TMPRSS6 | 1.70e-01 | peptidase | NA | NA | 3.0e-02 | CDKN1A,PROM1,SERPINE1 | NA |
| TRIM31 | NA | enzyme | NA | NA | 3.0e-02 | CDKN1A,PDK4,PPARG | NA |
| PURA | 1.90e-01 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,ITGAL,MYC | NA |
| miR-129-5p (and other miRNAs w/seed UUUUUGC) | NA | mature microRNA | NA | NA | 3.0e-02 | BMPR2,ETV6,TP53INP1 | NA |
| BLNK | 2.00e-01 | other | NA | NA | 3.0e-02 | BCL2L1,FOXO1,JUN | NA |
| MAPKAP1 | 1.80e-01 | other | NA | NA | 3.0e-02 | CXCL10,OAS2,SREBF1 | NA |
| TNFAIP2 | -2.90e-01 | other | NA | NA | 3.0e-02 | FGL2,IRF1,MERTK | NA |
| DBI | 4.20e-01 | other | NA | NA | 3.0e-02 | PPARD,PPARG,SQLE | NA |
| IL2RB | -6.10e-01 | transmembrane receptor | NA | NA | 3.0e-02 | CD244,JUN,MYC | NA |
| VIPR1 | -3.60e-01 | G-protein coupled receptor | NA | NA | 3.0e-02 | CCL4,CXCL10,IRF1 | NA |
| MS4A1 | -1.90e-01 | other | NA | NA | 3.0e-02 | CD22,HK2,MYC | NA |
| Gm12602 | NA | other | NA | NA | 3.0e-02 | BTG2,CGREF1,RGS16 | NA |
| costunolide | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | BCL2,CHEK2,MYC | NA |
| 2-acetylaminofluorene | NA | chemical toxicant | NA | NA | 3.0e-02 | BCL2,CCND1,CDKN1A | NA |
| concanamycin A | NA | chemical drug | NA | NA | 3.0e-02 | MET,NFKBIA,PPARG | NA |
| sanglifehrin A | NA | chemical reagent | NA | NA | 3.0e-02 | CD38,CDKN1A,CXCL10 | NA |
| hydrogen sulfide | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | BCL2,BCL2L1,TMPRSS2 | NA |
| N1,N11-diethylnorspermine | NA | chemical drug | NA | NA | 3.0e-02 | CCND1,CDKN1A,SAT1 | NA |
| spermidine | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | AMD1,CDKN1A,SAT1 | NA |
| lipofermata | NA | chemical reagent | NA | NA | 3.0e-02 | ATF4,BCL2,FGF2,PPARG | NA |
| JUN/JUNB/JUND | NA | group | NA | NA | 3.0e-02 | BCL2L1,COL7A1,JUN,PTPRO | NA |
| ZIC1 | NA | transcription regulator | NA | NA | 3.0e-02 | CCL24,CCND1,CX3CL1,CXCL17 | NA |
| CUX1 | 6.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,CXCL10,LILRB3,LIMA1,MYC,THBS1,WNT5A | NA |
| OSMI-1 | NA | chemical reagent | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| pervanadate | NA | chemical reagent | NA | NA | 3.0e-02 | IRF1,NFKBIA | NA |
| Histone H2b | NA | group | NA | NA | 3.0e-02 | Ifi47,IRF1 | NA |
| triptonide | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | CCND1,MYC | NA |
| CK1 | NA | group | NA | NA | 3.0e-02 | CSF3,PPARG | NA |
| rh-endostatin | NA | chemical drug | NA | NA | 3.0e-02 | JUN,TMPRSS2 | NA |
| NLGN1 | 6.00e-02 | enzyme | NA | NA | 3.0e-02 | CCND1,MYC | NA |
| MTO1 | 2.00e-01 | enzyme | NA | NA | 3.0e-02 | CCND1,MYC | NA |
| IGF2BP2 | -5.60e-01 | translation regulator | NA | NA | 3.0e-02 | LIMS2,SREBF1 | NA |
| PRDM4 | -1.30e-01 | transcription regulator | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| SH2D5 | 3.00e-02 | other | NA | NA | 3.0e-02 | BCL2L1,CCND1 | NA |
| AKIRIN2 | 2.50e-01 | other | NA | NA | 3.0e-02 | CCND1,MYC | NA |
| ATE1 | 1.50e-01 | enzyme | NA | NA | 3.0e-02 | CCND1,JUN | NA |
| DGAT2 | -1.10e-01 | enzyme | NA | NA | 3.0e-02 | GPAM,SREBF1 | NA |
| PNO1 | 4.70e-01 | other | NA | NA | 3.0e-02 | ATG7,BCL2 | NA |
| WNT16 | 1.60e-01 | other | NA | NA | 3.0e-02 | AXIN2,CDKN1A | NA |
| RDH8 | NA | enzyme | NA | NA | 3.0e-02 | CCL4,CXCL10 | NA |
| sphingomyelinase | NA | group | NA | NA | 3.0e-02 | JUN,MYC | NA |
| sepantronium | NA | chemical drug | NA | NA | 3.0e-02 | BCL2L1,MYC | NA |
| HNRNPR | 2.40e-01 | other | NA | NA | 3.0e-02 | PLK2,THBS1 | NA |
| RHEB | 2.70e-01 | enzyme | NA | NA | 3.0e-02 | IRS1,IRS2 | NA |
| WNK1 | 2.00e-02 | kinase | NA | NA | 3.0e-02 | SERPINE1,SLC12A3 | NA |
| miR-874-3p (miRNAs w/seed UGCCCUG) | NA | mature microRNA | NA | NA | 3.0e-02 | ADAM19,LEP | NA |
| PDE3A | 7.00e-02 | enzyme | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| EIF5A | 3.00e-01 | translation regulator | NA | NA | 3.0e-02 | CDKN1A,PEAK1 | NA |
| BANCR | NA | other | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| HOXC-AS3 | NA | other | NA | NA | 3.0e-02 | HK2,PDK4 | NA |
| ST13 | -1.10e-01 | other | NA | NA | 3.0e-02 | CEBPD,PPARG | NA |
| GABBR2 | 3.00e-02 | G-protein coupled receptor | NA | NA | 3.0e-02 | GLUL,GRIA2 | NA |
| BRCA2 | 5.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,SERPINE1 | NA |
| TMPO | -4.50e-01 | other | NA | NA | 3.0e-02 | COL12A1,MMP15 | NA |
| FOXE1 | 4.00e-02 | transcription regulator | NA | NA | 3.0e-02 | TPO,WNT5A | NA |
| RAD9A | -4.50e-01 | enzyme | NA | NA | 3.0e-02 | CDKN1A,KLF12 | NA |
| MLLT3 | NA | transcription regulator | NA | NA | 3.0e-02 | MYC,SGK1 | NA |
| GJA8 | NA | transporter | NA | NA | 3.0e-02 | ATF4,IRS2 | NA |
| SHCBP1 | 4.00e-02 | other | NA | NA | 3.0e-02 | CCND1,PROM1 | NA |
| ERBIN | 1.60e-01 | other | NA | NA | 3.0e-02 | CDKN1A,SERPINE1 | NA |
| SNX1 | 1.60e-01 | transporter | NA | NA | 3.0e-02 | AGTR1,SLC12A3 | NA |
| NKX3-2 | NA | transcription regulator | NA | NA | 3.0e-02 | FGF10,FGFR3 | NA |
| PTGDS | 3.00e-02 | enzyme | NA | NA | 3.0e-02 | BCL2L1,PTPN11 | NA |
| CDC20 | -3.90e-01 | other | NA | NA | 3.0e-02 | BCL2,CFLAR | NA |
| ABCB7 | 4.00e-02 | transporter | NA | NA | 3.0e-02 | FTL,TFRC | NA |
| KLKB1 | 4.00e-02 | peptidase | NA | NA | 3.0e-02 | KLF4,MAS1 | NA |
| PLAC8 | NA | other | NA | NA | 3.0e-02 | CCND1,CDKN1A | NA |
| NPAS2 | -3.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CRY1,PER1 | NA |
| FUBP1 | -1.10e-01 | transcription regulator | NA | NA | 3.0e-02 | MYC,WNT5A | NA |
| CTH | NA | enzyme | NA | NA | 3.0e-02 | CDKN1A,CX3CR1 | NA |
| A939572 | NA | chemical reagent | NA | NA | 3.0e-02 | ATF4,LRAT | NA |
| TNIK | NA | kinase | NA | NA | 3.0e-02 | AXIN2,CCND1 | NA |
| Brd4 | -1.00e-02 | kinase | NA | NA | 3.0e-02 | NFKBIA,SERPINE1 | NA |
| PRN694 | NA | chemical drug | NA | NA | 3.0e-02 | NFKBIA,NFKBIZ | NA |
| iCRT3 | NA | chemical reagent | NA | NA | 3.0e-02 | AXIN2,PROM1 | NA |
| nicorandil | NA | chemical drug | NA | NA | 3.0e-02 | BCL2,JUN | NA |
| dacarbazine | NA | chemical drug | NA | NA | 3.0e-02 | CDKN1A,CXCL10 | NA |
| Proteasome | NA | complex | NA | NA | 3.0e-02 | NFKBIA,SREBF1 | NA |
| butylbenzyl phthalate | NA | chemical toxicant | NA | NA | 3.0e-02 | MYC,STAR | NA |
| murabutide | NA | chemical reagent | NA | NA | 3.0e-02 | CD83,MRC1 | NA |
| LY83583 | NA | chemical reagent | NA | NA | 3.0e-02 | CDKN1A,HSD11B2 | NA |
| dobutamine | NA | chemical drug | NA | NA | 3.0e-02 | CXCL10,LEP | NA |
| L-cystine | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | ATF4,BTG1 | NA |
| N-acetyl-L-aspartic acid | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | ASPA,MRC1 | NA |
| ML385 | NA | chemical reagent | NA | NA | 3.0e-02 | ATG7,SREBF1 | NA |
| HRH3 | -1.59e+00 | G-protein coupled receptor | NA | NA | 3.0e-02 | ADRB3,CITED1,CXCL10,LEP,TMEM45B | NA |
| ATF1 | 1.20e-01 | transcription regulator | NA | NA | 3.0e-02 | BCL2,JUN,PDE3B,TEAD1,THBS1 | NA |
| naringenin | NA | chemical - endogenous non-mammalian | NA | NA | 3.0e-02 | CCL4,CXCL10,NR3C1,SREBF1,TLR2 | NA |
| doxifluridine | NA | chemical drug | NA | NA | 3.0e-02 | CDKN1A,GADD45A,TP53INP1 | NA |
| bevacizumab | NA | biologic drug | NA | NA | 3.0e-02 | KDR,NRP1,PGF | NA |
| Integrin | NA | complex | NA | NA | 3.0e-02 | CCND1,JUN,MYC | NA |
| VSIR | -4.70e-01 | other | NA | NA | 3.0e-02 | CIDEC,CXCL10,PPARG | NA |
| ZC3H14 | 7.00e-02 | other | NA | NA | 3.0e-02 | FGL2,MERTK,TSC22D1 | NA |
| Hmgb1 | 5.00e-02 | transcription regulator | NA | NA | 3.0e-02 | BCL2,CCND1,CDKN1A | NA |
| PSMB8 | -5.40e-01 | peptidase | NA | NA | 3.0e-02 | IRS1,NFKB2,NFKBIA | NA |
| LBP | -1.30e-01 | transporter | NA | NA | 3.0e-02 | CXCL10,IL1RN,TLR2 | NA |
| mir-192 | NA | microRNA | NA | NA | 3.0e-02 | CDKN1A,CUL5,JUN | NA |
| LAMA5 | 9.00e-02 | other | NA | NA | 3.0e-02 | CCL4,CSF3,CXCL10 | NA |
| SRSF3 | 5.10e-01 | other | NA | NA | 3.0e-02 | BCL2,CCND1,JUN | NA |
| GAL | 1.01e+00 | other | NA | NA | 3.0e-02 | BCL2,CDKN1A,LEP | NA |
| MMP8 | 0.00e+00 | peptidase | NA | NA | 3.0e-02 | CXCL10,MET,NR3C1 | NA |
| NCAM1 | -4.00e-02 | other | NA | NA | 3.0e-02 | GLUL,NFKBIA,THBS1 | NA |
| CNOT3 | 7.00e-02 | other | NA | NA | 3.0e-02 | CDKN1A,MYC,PDK4 | NA |
| CCAT2 | NA | other | NA | NA | 3.0e-02 | BCL2,CCND1,MYC | NA |
| TARBP2 | -3.40e-01 | other | NA | NA | 3.0e-02 | MYC,MYH7B,THBS1 | NA |
| SMAD6 | -2.00e-02 | transcription regulator | NA | NA | 3.0e-02 | NFATC1,PROM1,SERPINE1 | NA |
| HDAC8 | -6.00e-02 | transcription regulator | NA | NA | 3.0e-02 | CDKN1A,Pmaip1,STX1A | NA |
| premarin | NA | chemical drug | NA | NA | 3.0e-02 | BCL2,MYC,SERPINE1 | NA |
| polyamines | NA | chemical - other | NA | NA | 3.0e-02 | PPARG,SAT1,TLR2 | NA |
| zearalenone | NA | chemical toxicant | NA | NA | 3.0e-02 | BCL2L1,CCND1,MYC | NA |
| DIM-C-pPhOH-3-Cl-5-OCH3 | NA | chemical reagent | NA | NA | 3.0e-02 | BCL2,MYC,PHKG1 | NA |
| 2-arachidonoylglycerol | NA | chemical - endogenous mammalian | NA | NA | 3.0e-02 | FGF2,PPARD,PPARG | NA |
| ethidium | NA | chemical drug | NA | NA | 3.0e-02 | BCL2,CCND1,SERPINE1 | NA |
| TAF6 | 3.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A,GADD45A,IRF1,JUN | NA |
| FANCC | -3.60e-01 | other | NA | NA | 4.0e-02 | AXIN2,FHL2,IFI44L,NR3C1,NUAK1,RND3,WNT5A | NA |
| myclobutanil | NA | chemical toxicant | NA | NA | 4.0e-02 | ADH1C,CYP2B6,HSD11B1,SLC3A2,SQLE | NA |
| Laminin (complex) | NA | complex | NA | NA | 4.0e-02 | BIRC3,CCND1,SDC4,SERPINE1,WNT5A | NA |
| EED | 1.70e-01 | transcription regulator | NA | NA | 4.0e-02 | GATA6,KLF4,MYC,SLC26A6,TBX3 | NA |
| IFNE | NA | cytokine | NA | NA | 4.0e-02 | CD83,CDKN1A,CXCL10,CXCL11,HSD11B1 | NA |
| GSTP1 | 3.70e-01 | enzyme | NA | NA | 4.0e-02 | CBS/LOC102724560,DTL,Fam13a,FKBP5,GPC2,IL22RA2,JUN,LYVE1,PER1,RAB27A,SERPINE1,Tchh,TEAD2 | NA |
| olaparib | NA | chemical drug | NA | NA | 4.0e-02 | BTG2,CCND1,CDKN1A,CXCL10 | NA |
| SFRP4 | 4.60e-01 | transmembrane receptor | NA | NA | 4.0e-02 | AXIN2,CCND1,GREM2,MYC | NA |
| CPE | -1.30e-01 | peptidase | NA | NA | 4.0e-02 | BCL2,LEP,MYC,PENK | NA |
| PLAGL1 | -1.15e+00 | transcription regulator | NA | NA | 4.0e-02 | ADCYAP1R1,CCL24,CDKN1A,PPARG | NA |
| 15(S)-HETE | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | FGF2,JUN,PPARG | NA |
| mannitol | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | FOXO3,HDC,JUN | NA |
| RNA fragment | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | IKBKE,MYC,NFKBIA | NA |
| Fcgr3 | NA | group | NA | NA | 4.0e-02 | CSF3,IL1RN,ITGAL | NA |
| cryptotanshinone | NA | chemical drug | NA | NA | 4.0e-02 | BCL2,BCL2L1,CHEK2 | NA |
| BMS-345541 | NA | chemical drug | NA | NA | 4.0e-02 | BACH2,NFKBIZ,ZNF395 | NA |
| DLX6 | -2.00e-01 | transcription regulator | NA | NA | 4.0e-02 | BMPER,CITED1,PLAGL1 | NA |
| CYB561A3 | -5.70e-01 | enzyme | NA | NA | 4.0e-02 | FTL,TFRC,TP53I11 | NA |
| EGLN2 | 1.90e-01 | enzyme | NA | NA | 4.0e-02 | EGLN3,EPAS1,IRS2 | NA |
| Endothelin | NA | group | NA | NA | 4.0e-02 | APLN,JUN,MYC | NA |
| ALDH1A1 | -5.20e-01 | enzyme | NA | NA | 4.0e-02 | PPARD,PPARG,ZNF423 | NA |
| Cyp2c23 | -5.00e-02 | enzyme | NA | NA | 4.0e-02 | ASPA,CX3CR1,MERTK | NA |
| CSDE1 | -1.20e-01 | enzyme | NA | NA | 4.0e-02 | MYC,RPL9,SDC4 | NA |
| CCN4 | NA | other | NA | NA | 4.0e-02 | AXIN2,BCL2L1,CCND1 | NA |
| miR-100-5p (and other miRNAs w/seed ACCCGUA) | NA | mature microRNA | NA | NA | 4.0e-02 | CCND1,FGFR3,SOX17 | NA |
| mir-322 | NA | microRNA | NA | NA | 4.0e-02 | BCL2,FGF2,SMAD7 | NA |
| CHEK2 | -6.00e-01 | kinase | NA | NA | 4.0e-02 | BCL2L1,CDKN1A,Pmaip1 | NA |
| FMO3 | 1.09e+00 | enzyme | NA | NA | 4.0e-02 | FOXO1,PDK4,SREBF1 | NA |
| TBX3 | 1.02e+00 | transcription regulator | NA | NA | 4.0e-02 | GATA6,GJA5,LBH | NA |
| PDGFRA | -8.00e-02 | kinase | NA | NA | 4.0e-02 | CDKN1A,MYC,NOG | NA |
| SOD3 | 2.00e-02 | enzyme | NA | NA | 4.0e-02 | EDNRA,EDNRB,MITF | NA |
| EREG | 2.00e-01 | growth factor | NA | NA | 4.0e-02 | FGF2,HAS2,PGF | NA |
| XPO1 | -2.10e-01 | transporter | NA | NA | 4.0e-02 | CCND1,CDKN1A,MET | NA |
| DMH1 | NA | chemical reagent | NA | NA | 4.0e-02 | LOX,MRC1,STAR | NA |
| isoliquiritigenin | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | BCL2,CDKN1A,KDR | NA |
| TBP | 4.00e-01 | transcription regulator | NA | NA | 4.0e-02 | BCL2,CDKN1A,EDNRA,MYC,NFKBIA,PPARG,RANBP1 | NA |
| 9-hydroxy-(S)-10,12-octadecadienoic acid | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | SERPINE1 | NA |
| garcinoic acid | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | PPARG | NA |
| BI8626 | NA | chemical reagent | NA | NA | 4.0e-02 | MYC | NA |
| SZB120 | NA | chemical reagent | NA | NA | 4.0e-02 | NFKBIZ | NA |
| UDP-N-acetylglucosamine | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | LEP | NA |
| 8-chloroadenosine | NA | chemical drug | NA | NA | 4.0e-02 | MET | NA |
| BLU 9931 | NA | chemical drug | NA | NA | 4.0e-02 | CCND1 | NA |
| xylose | NA | chemical reagent | NA | NA | 4.0e-02 | SREBF1 | NA |
| beta-escin | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| chromomycin A3 | NA | chemical toxicant | NA | NA | 4.0e-02 | CX3CL1 | NA |
| 6beta-hydroxyestradiol-17beta | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | CYP2B6 | NA |
| GSK-2033 | NA | chemical reagent | NA | NA | 4.0e-02 | SREBF1 | NA |
| 11beta-HSD1 inhibitor 10J | NA | chemical reagent | NA | NA | 4.0e-02 | LOX | NA |
| SMAP2 | NA | chemical reagent | NA | NA | 4.0e-02 | MYC | NA |
| A-485 | NA | chemical reagent | NA | NA | 4.0e-02 | MYC | NA |
| Keratin 16 | NA | group | NA | NA | 4.0e-02 | CCND1 | NA |
| STF-1019 | NA | chemical drug | NA | NA | 4.0e-02 | PI4K2A | NA |
| Il2 beta gamma receptor | NA | complex | NA | NA | 4.0e-02 | BCL2L1 | NA |
| A-92 | NA | chemical drug | NA | NA | 4.0e-02 | MYC | NA |
| ProAgio | NA | biologic drug | NA | NA | 4.0e-02 | LOX | NA |
| cortivazol | NA | chemical reagent | NA | NA | 4.0e-02 | NR3C1 | NA |
| deflazacort | NA | chemical drug | NA | NA | 4.0e-02 | EDNRA | NA |
| flavokawain C | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | CFLAR | NA |
| LM-1685 | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1 | NA |
| MRGPRX2 | -6.00e-02 | G-protein coupled receptor | NA | NA | 4.0e-02 | CCL4 | NA |
| ALG10 | 7.80e-01 | enzyme | NA | NA | 4.0e-02 | PROM1 | NA |
| PIK3R6 | 0.00e+00 | kinase | NA | NA | 4.0e-02 | PIK3CG | NA |
| Pokeweed Mitogen | NA | chemical drug | NA | NA | 4.0e-02 | FGF2 | NA |
| miR-378a-3p inhibitor | NA | chemical reagent | NA | NA | 4.0e-02 | TRAF1 | NA |
| lactotrehalose | NA | chemical reagent | NA | NA | 4.0e-02 | NAMPT | NA |
| Z31216525 | NA | chemical reagent | NA | NA | 4.0e-02 | MYC | NA |
| GSK-LSD1 | NA | chemical reagent | NA | NA | 4.0e-02 | MYC | NA |
| mitotam | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| ORG 34517 | NA | chemical drug | NA | NA | 4.0e-02 | NR3C2 | NA |
| TRAPPC9 | 1.70e-01 | other | NA | NA | 4.0e-02 | BCL2L1 | NA |
| glutaminase inhibitor 968 | NA | chemical reagent | NA | NA | 4.0e-02 | ATF4 | NA |
| lapachol | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | SERPINE1 | NA |
| Ggt | NA | group | NA | NA | 4.0e-02 | SLC7A5 | NA |
| Integrinβ | NA | group | NA | NA | 4.0e-02 | NOG | NA |
| Timp | NA | group | NA | NA | 4.0e-02 | BCL2L1 | NA |
| eIF2B | NA | complex | NA | NA | 4.0e-02 | ATF4 | NA |
| glutathione peroxidase | NA | group | NA | NA | 4.0e-02 | CFLAR | NA |
| CaMK I | NA | group | NA | NA | 4.0e-02 | STAR | NA |
| Pp2b | NA | complex | NA | NA | 4.0e-02 | ALOX12 | NA |
| INSC | -5.90e-01 | other | NA | NA | 4.0e-02 | KDR | NA |
| Max-Myc | NA | complex | NA | NA | 4.0e-02 | CFLAR | NA |
| barasertib | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L1 | NA |
| 1,7-dimethylxanthine | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | HSD11B2 | NA |
| Ahr-aryl hydrocarbon-RelA | NA | complex | NA | NA | 4.0e-02 | MYC | NA |
| PEG-interferon alfa-2a | NA | biologic drug | NA | NA | 4.0e-02 | CXCL10 | NA |
| G-Actin | NA | group | NA | NA | 4.0e-02 | JUN | NA |
| tandospirone | NA | chemical drug | NA | NA | 4.0e-02 | PER1 | NA |
| 3-iodothyronamine | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | IRS2 | NA |
| 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole | NA | chemical - kinase inhibitor | NA | NA | 4.0e-02 | CCL24 | NA |
| sodium thiosulfate | NA | chemical drug | NA | NA | 4.0e-02 | BCL2 | NA |
| RFX8 | -3.90e-01 | transcription regulator | NA | NA | 4.0e-02 | DDX24 | NA |
| HCG11 | NA | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| LINC00475 | NA | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| NCK | NA | group | NA | NA | 4.0e-02 | CCND1 | NA |
| CYP2R1 | -4.20e-01 | enzyme | NA | NA | 4.0e-02 | VDR | NA |
| TCEAL7 | -7.00e-02 | transcription regulator | NA | NA | 4.0e-02 | BCL2L1 | NA |
| NUDT6 | 4.80e-01 | enzyme | NA | NA | 4.0e-02 | FGF2 | NA |
| MOGS | NA | enzyme | NA | NA | 4.0e-02 | PROM1 | NA |
| FUNDC1 | 8.00e-02 | other | NA | NA | 4.0e-02 | KDR | NA |
| ALG2 | 1.30e-01 | enzyme | NA | NA | 4.0e-02 | CREB3L2 | NA |
| PPME1 | 1.20e-01 | enzyme | NA | NA | 4.0e-02 | PPP2R2A | NA |
| LMTK3 | 4.00e-02 | kinase | NA | NA | 4.0e-02 | HSPB8 | NA |
| MCM8 | 4.20e-01 | enzyme | NA | NA | 4.0e-02 | BCL2L1 | NA |
| RGN | 2.60e-01 | enzyme | NA | NA | 4.0e-02 | BCL2 | NA |
| ALG8 | 1.00e-01 | enzyme | NA | NA | 4.0e-02 | PROM1 | NA |
| TMEM178A | 4.40e-01 | other | NA | NA | 4.0e-02 | NFATC1 | NA |
| CD3-TCR | NA | complex | NA | NA | 4.0e-02 | TOB1 | NA |
| REG4 | 1.00e-02 | other | NA | NA | 4.0e-02 | BCL2L1 | NA |
| KREMEN1 | -4.00e-01 | other | NA | NA | 4.0e-02 | AXIN2 | NA |
| KLHL13 | 7.00e-02 | enzyme | NA | NA | 4.0e-02 | IRS1 | NA |
| KCNJ12 | -4.20e-01 | ion channel | NA | NA | 4.0e-02 | CCND1 | NA |
| ARMC10 | -8.00e-02 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| CALCOCO1 | 4.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CCND1 | NA |
| URGCP | 1.30e-01 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| ARHGAP35 | -1.80e-01 | transcription regulator | NA | NA | 4.0e-02 | KDR | NA |
| FKBPL | -4.40e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| ZBTB7C | -4.70e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| C1orf35 | NA | other | NA | NA | 4.0e-02 | MYC | NA |
| SGC (family) | NA | group | NA | NA | 4.0e-02 | BCL2L1 | NA |
| PPP1R3G | -8.60e-01 | other | NA | NA | 4.0e-02 | SREBF1 | NA |
| RDH11 | -3.00e-02 | enzyme | NA | NA | 4.0e-02 | NR3C1 | NA |
| MACROD1 | -1.70e-01 | enzyme | NA | NA | 4.0e-02 | NFKBIA | NA |
| VIRMA | NA | other | NA | NA | 4.0e-02 | WEE1 | NA |
| CXXC1 | -6.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| PART1 | NA | other | NA | NA | 4.0e-02 | ZBTB16 | NA |
| CCDC22 | -1.20e-01 | other | NA | NA | 4.0e-02 | BIRC3 | NA |
| ALG6 | -1.00e-02 | enzyme | NA | NA | 4.0e-02 | PROM1 | NA |
| PLEKHN1 | -3.30e-01 | other | NA | NA | 4.0e-02 | LEP | NA |
| CCDC62 | -7.00e-01 | transcription regulator | NA | NA | 4.0e-02 | CCND1 | NA |
| CDCA4 | 2.00e-02 | other | NA | NA | 4.0e-02 | GMNN | NA |
| ZBTB8A | -1.10e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| PABIR1 | NA | other | NA | NA | 4.0e-02 | WEE1 | NA |
| ALG5 | 2.20e-01 | enzyme | NA | NA | 4.0e-02 | PROM1 | NA |
| IFT80 | -3.00e-02 | other | NA | NA | 4.0e-02 | TRAF6 | NA |
| ZNF606 | -4.40e-01 | transcription regulator | NA | NA | 4.0e-02 | CX3CL1 | NA |
| HSPA6 | NA | enzyme | NA | NA | 4.0e-02 | SPHK1 | NA |
| GPR87 | -1.00e-02 | G-protein coupled receptor | NA | NA | 4.0e-02 | PROM1 | NA |
| HASPIN | NA | kinase | NA | NA | 4.0e-02 | CDKN1A | NA |
| SCYL2 | 1.00e-02 | other | NA | NA | 4.0e-02 | WNT5A | NA |
| CLPTM1L | 1.40e-01 | other | NA | NA | 4.0e-02 | BCL2L1 | NA |
| RNF149 | 1.40e-01 | enzyme | NA | NA | 4.0e-02 | BRAF | NA |
| MKKS | -3.10e-01 | other | NA | NA | 4.0e-02 | LEP | NA |
| 1-aminoindan | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | BCL2L1 | NA |
| OSBP | -4.00e-02 | transporter | NA | NA | 4.0e-02 | SREBF1 | NA |
| KLHL9 | -6.00e-02 | enzyme | NA | NA | 4.0e-02 | IRS1 | NA |
| PDCL3 | 4.20e-01 | other | NA | NA | 4.0e-02 | KDR | NA |
| PLAC1 | 9.00e-02 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| CDYL2 | -2.60e-01 | other | NA | NA | 4.0e-02 | SLC7A6 | NA |
| PNRC2 | 2.30e-01 | other | NA | NA | 4.0e-02 | LEP | NA |
| METAP2 | 1.90e-01 | peptidase | NA | NA | 4.0e-02 | BCL2 | NA |
| DHODH | 2.10e-01 | enzyme | NA | NA | 4.0e-02 | CFLAR | NA |
| FANK1 | 2.00e-02 | transcription regulator | NA | NA | 4.0e-02 | JUN | NA |
| PCGF5 | -6.00e-02 | other | NA | NA | 4.0e-02 | MCC | NA |
| SLC4A7 | 4.90e-01 | transporter | NA | NA | 4.0e-02 | SLC16A1 | NA |
| RBM47 | 9.40e-01 | other | NA | NA | 4.0e-02 | FOXO3 | NA |
| Gata6os | NA | other | NA | NA | 4.0e-02 | GATA6 | NA |
| NDUFA11 | 2.60e-01 | enzyme | NA | NA | 4.0e-02 | ATF4 | NA |
| OTUD6B | 4.20e-01 | peptidase | NA | NA | 4.0e-02 | EPAS1 | NA |
| MGAT4C | NA | enzyme | NA | NA | 4.0e-02 | PROM1 | NA |
| NVP-AEW541 | NA | chemical drug | NA | NA | 4.0e-02 | TYRO3 | NA |
| 7-bromoindirubin-3’-oxime | NA | chemical - kinase inhibitor | NA | NA | 4.0e-02 | CDKN1A | NA |
| mapatumumab | NA | biologic drug | NA | NA | 4.0e-02 | CFLAR | NA |
| galiximab | NA | biologic drug | NA | NA | 4.0e-02 | BCL2L1 | NA |
| black cohosh extract | NA | chemical drug | NA | NA | 4.0e-02 | SERPINE1 | NA |
| inolitazone | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A | NA |
| proprotein convertase | NA | group | NA | NA | 4.0e-02 | STAR | NA |
| Integrin alpha 5 beta 1 | NA | complex | NA | NA | 4.0e-02 | CCND1 | NA |
| Mannosidase2 | NA | group | NA | NA | 4.0e-02 | PROM1 | NA |
| Mapk kinase | NA | group | NA | NA | 4.0e-02 | CCND1 | NA |
| GLIPR1 | -2.60e-01 | other | NA | NA | 4.0e-02 | MYC | NA |
| NSMCE3 | NA | other | NA | NA | 4.0e-02 | MYC | NA |
| DLAT | 1.90e-01 | enzyme | NA | NA | 4.0e-02 | CISH | NA |
| GDF1 | -1.00e-01 | growth factor | NA | NA | 4.0e-02 | SOX17 | NA |
| PMF1/PMF1-BGLAP | 3.20e-01 | transcription regulator | NA | NA | 4.0e-02 | SAT1 | NA |
| PF-4523655 | NA | biologic drug | NA | NA | 4.0e-02 | DDIT4 | NA |
| BMS-309403 | NA | chemical reagent | NA | NA | 4.0e-02 | PPARG | NA |
| PRCC | -2.10e-01 | other | NA | NA | 4.0e-02 | SERPINE1 | NA |
| Tenascin | NA | group | NA | NA | 4.0e-02 | CCND1 | NA |
| afuresertib | NA | chemical drug | NA | NA | 4.0e-02 | CBLB | NA |
| DYNLRB1 | 3.30e-01 | other | NA | NA | 4.0e-02 | SERPINE1 | NA |
| RBMS1 | -1.40e-01 | other | NA | NA | 4.0e-02 | MYC | NA |
| LXN | -3.70e-01 | other | NA | NA | 4.0e-02 | PPARG | NA |
| SYTL4 | -3.70e-01 | transporter | NA | NA | 4.0e-02 | STX1A | NA |
| KHK | 7.00e-02 | kinase | NA | NA | 4.0e-02 | SLC2A5 | NA |
| SRSF9 | -1.60e-01 | enzyme | NA | NA | 4.0e-02 | NR3C1 | NA |
| DNAJC14 | -2.00e-01 | other | NA | NA | 4.0e-02 | AGTR1 | NA |
| GRIA3 | 4.80e-01 | ion channel | NA | NA | 4.0e-02 | LEP | NA |
| CABLES1 | -5.70e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| PPP2CB | 3.10e-01 | phosphatase | NA | NA | 4.0e-02 | CLSPN | NA |
| NAPA | 2.40e-01 | transporter | NA | NA | 4.0e-02 | BCL2 | NA |
| RRAS | 1.40e-01 | enzyme | NA | NA | 4.0e-02 | BCL2L1 | NA |
| RNPS1 | 2.70e-01 | other | NA | NA | 4.0e-02 | BCL2L1 | NA |
| CDT1 | -5.60e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| OCRL | -8.00e-02 | phosphatase | NA | NA | 4.0e-02 | MET | NA |
| CDC45 | -3.60e-01 | other | NA | NA | 4.0e-02 | MYC | NA |
| ACVR2B | 2.30e-01 | kinase | NA | NA | 4.0e-02 | CDKN1A | NA |
| EXTL2 | -3.40e-01 | enzyme | NA | NA | 4.0e-02 | SDC4 | NA |
| GR 82334 | NA | biologic drug | NA | NA | 4.0e-02 | CXCL10 | NA |
| GPR21 | -2.80e-01 | G-protein coupled receptor | NA | NA | 4.0e-02 | PRF1 | NA |
| MKRN1 | NA | enzyme | NA | NA | 4.0e-02 | KCNH1 | NA |
| HNRNPM | -7.00e-02 | other | NA | NA | 4.0e-02 | WNT5A | NA |
| Mkrn1 | 1.30e-01 | enzyme | NA | NA | 4.0e-02 | KCNH1 | NA |
| ADCY2 | -1.30e-01 | enzyme | NA | NA | 4.0e-02 | CCND1 | NA |
| miR-523-3p (miRNAs w/seed AACGCGC) | NA | mature microRNA | NA | NA | 4.0e-02 | CDKN1A | NA |
| mir-363 | NA | microRNA | NA | NA | 4.0e-02 | MYC | NA |
| miR-190a-5p (and other miRNAs w/seed GAUAUGU) | NA | mature microRNA | NA | NA | 4.0e-02 | HUS1 | NA |
| miR-377-3p (miRNAs w/seed UCACACA) | NA | mature microRNA | NA | NA | 4.0e-02 | TEAD1 | NA |
| miR-4472 (and other miRNAs w/seed GUGGGGG) | NA | mature microRNA | NA | NA | 4.0e-02 | NR1D1 | NA |
| miR-377-5p (and other miRNAs w/seed GAGGUUG) | NA | mature microRNA | NA | NA | 4.0e-02 | PRDX6 | NA |
| mir-617 | NA | microRNA | NA | NA | 4.0e-02 | SERPINE1 | NA |
| mir-198 | NA | microRNA | NA | NA | 4.0e-02 | CCNT1 | NA |
| miR-455-5p (and other miRNAs w/seed AUGUGCC) | NA | mature microRNA | NA | NA | 4.0e-02 | EPAS1 | NA |
| miR-605-5p (miRNAs w/seed AAAUCCC) | NA | mature microRNA | NA | NA | 4.0e-02 | SEC24D | NA |
| mir-491 | NA | microRNA | NA | NA | 4.0e-02 | BCL2L1 | NA |
| miR-706 (miRNAs w/seed GAGAAAC) | NA | mature microRNA | NA | NA | 4.0e-02 | SLC3A2 | NA |
| miR-4651 (and other miRNAs w/seed GGGGUGG) | NA | mature microRNA | NA | NA | 4.0e-02 | BCL2L1 | NA |
| mir-1301 | NA | microRNA | NA | NA | 4.0e-02 | KLF6 | NA |
| miR-105-5p (and other miRNAs w/seed CAAAUGC) | NA | mature microRNA | NA | NA | 4.0e-02 | TLR2 | NA |
| miR-2861 (and other miRNAs w/seed GGGCCUG) | NA | mature microRNA | NA | NA | 4.0e-02 | HDAC5 | NA |
| miR-571 (miRNAs w/seed GAGUUGG) | NA | mature microRNA | NA | NA | 4.0e-02 | GMNN | NA |
| mir-887 | NA | microRNA | NA | NA | 4.0e-02 | PLD2 | NA |
| miR-934 (miRNAs w/seed GUCUACU) | NA | mature microRNA | NA | NA | 4.0e-02 | PTPN11 | NA |
| MIR3619 | NA | microRNA | NA | NA | 4.0e-02 | PLD2 | NA |
| KREMEN2 | NA | other | NA | NA | 4.0e-02 | AXIN2 | NA |
| PLSCR3 | -3.30e-01 | enzyme | NA | NA | 4.0e-02 | LEP | NA |
| DYNLT3 | 1.50e-01 | other | NA | NA | 4.0e-02 | BCL2 | NA |
| TIMELESS | -2.50e-01 | other | NA | NA | 4.0e-02 | PER1 | NA |
| GOLGA3 | 2.40e-01 | transporter | NA | NA | 4.0e-02 | SRR | NA |
| USP33 | -1.60e-01 | peptidase | NA | NA | 4.0e-02 | EPAS1 | NA |
| ZBTB5 | -2.60e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| DHX8 | 1.60e-01 | enzyme | NA | NA | 4.0e-02 | CDKN1A | NA |
| BORCS8-MEF2B | NA | transcription regulator | NA | NA | 4.0e-02 | JUN | NA |
| CNOT9 | 2.60e-01 | transcription regulator | NA | NA | 4.0e-02 | MYC | NA |
| CAMK2 | NA | group | NA | NA | 4.0e-02 | BIRC3 | NA |
| EPSTI1 | -3.10e-01 | other | NA | NA | 4.0e-02 | NFKBIA | NA |
| LINC00570 | NA | other | NA | NA | 4.0e-02 | ROCK2 | NA |
| thiazide diuretic | NA | chemical drug | NA | NA | 4.0e-02 | SLC12A3 | NA |
| TOB2 | 3.70e-01 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| REG1A | NA | growth factor | NA | NA | 4.0e-02 | BCL2L1 | NA |
| IFIT1 | -3.10e-01 | other | NA | NA | 4.0e-02 | CXCL10 | NA |
| PFKFB2 | -2.70e-01 | kinase | NA | NA | 4.0e-02 | PDK4 | NA |
| Zfp54 | -3.00e-01 | other | NA | NA | 4.0e-02 | PPARG | NA |
| GTPBP4 | 5.70e-01 | enzyme | NA | NA | 4.0e-02 | CCND1 | NA |
| RNF7 | 4.30e-01 | enzyme | NA | NA | 4.0e-02 | JUN | NA |
| DNASE1L3 | -6.00e-02 | enzyme | NA | NA | 4.0e-02 | CDKN1A | NA |
| PIK3R5 | -3.00e-02 | kinase | NA | NA | 4.0e-02 | PIK3CG | NA |
| forchlorfenuron | NA | chemical reagent | NA | NA | 4.0e-02 | SNAP25 | NA |
| CCNI | 1.00e-02 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| aloperine | NA | chemical reagent | NA | NA | 4.0e-02 | CFLAR | NA |
| melamine | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| DNAJC5 | 2.30e-01 | other | NA | NA | 4.0e-02 | SNAP25 | NA |
| 20-hydroxyprostaglandin E2 | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | PPARG | NA |
| FXYD1 | 2.20e-01 | ion channel | NA | NA | 4.0e-02 | CDKN1A | NA |
| GRB14 | -5.50e-01 | other | NA | NA | 4.0e-02 | IRS1 | NA |
| KIF11 | 1.60e-01 | other | NA | NA | 4.0e-02 | CFLAR | NA |
| CALML3 | 8.60e-01 | other | NA | NA | 4.0e-02 | MYO10 | NA |
| PPP1R3A | -2.60e-01 | phosphatase | NA | NA | 4.0e-02 | THBS1 | NA |
| PTPRU | -3.00e-01 | phosphatase | NA | NA | 4.0e-02 | CCND1 | NA |
| LRRC17 | -5.60e-01 | other | NA | NA | 4.0e-02 | NFATC1 | NA |
| KRT15 | NA | other | NA | NA | 4.0e-02 | TCF3 | NA |
| Zfp55 | NA | other | NA | NA | 4.0e-02 | PPARG | NA |
| PKD1L3 | 6.20e-01 | ion channel | NA | NA | 4.0e-02 | PKD2L1 | NA |
| Ikzf1 | 2.00e-02 | transcription regulator | NA | NA | 4.0e-02 | FGFR3 | NA |
| PMS2 | NA | enzyme | NA | NA | 4.0e-02 | CCND1 | NA |
| Sin3b | 3.60e-01 | transcription regulator | NA | NA | 4.0e-02 | MYC | NA |
| TUB | -1.60e-01 | transcription regulator | NA | NA | 4.0e-02 | NAMPT | NA |
| XPO7 | -1.80e-01 | transporter | NA | NA | 4.0e-02 | CDKN1A | NA |
| RNF125 | 2.00e-02 | enzyme | NA | NA | 4.0e-02 | TRIM14 | NA |
| Rnf125 | NA | enzyme | NA | NA | 4.0e-02 | TRIM14 | NA |
| BABAM2 | NA | other | NA | NA | 4.0e-02 | NFATC1 | NA |
| RIT1 | -2.00e-02 | enzyme | NA | NA | 4.0e-02 | BCL2 | NA |
| ING3 | 3.20e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| STK26 | -2.40e-01 | kinase | NA | NA | 4.0e-02 | AXIN2 | NA |
| TBXAS1 | 4.00e-02 | enzyme | NA | NA | 4.0e-02 | STAR | NA |
| 4-methoxyhonokiol | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | BCL2L1 | NA |
| PRDM2 | 1.00e-01 | transcription regulator | NA | NA | 4.0e-02 | MYC | NA |
| GNG3 | -4.10e-01 | enzyme | NA | NA | 4.0e-02 | LEP | NA |
| JADE1 | -4.70e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| ARHGAP29 | -2.00e-01 | other | NA | NA | 4.0e-02 | MYC | NA |
| ITIH4 | -4.90e-01 | other | NA | NA | 4.0e-02 | VDR | NA |
| CDK20 | -2.70e-01 | kinase | NA | NA | 4.0e-02 | CCND1 | NA |
| GDF10 | 9.00e-02 | growth factor | NA | NA | 4.0e-02 | SERPINE1 | NA |
| LNCRNA-IUR | NA | other | NA | NA | 4.0e-02 | TFRC | NA |
| LIN7B | 2.00e-01 | other | NA | NA | 4.0e-02 | LIN7C | NA |
| PTOV1 | -1.50e-01 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| direct black 38 | NA | chemical reagent | NA | NA | 4.0e-02 | TFRC | NA |
| UBE2E1 | -7.00e-02 | enzyme | NA | NA | 4.0e-02 | CDKN1A | NA |
| CUL9 | -2.00e-01 | other | NA | NA | 4.0e-02 | CDKN1A | NA |
| ADCY3 | -3.20e-01 | enzyme | NA | NA | 4.0e-02 | NRP1 | NA |
| PPP2R3A | -2.50e-01 | phosphatase | NA | NA | 4.0e-02 | MYC | NA |
| TPD52 | -1.30e-01 | other | NA | NA | 4.0e-02 | BCL2 | NA |
| FAM13A | NA | other | NA | NA | 4.0e-02 | IRS1 | NA |
| SCML2 | 1.20e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A | NA |
| LIN7A | 5.00e-02 | other | NA | NA | 4.0e-02 | LIN7C | NA |
| COX7A2 | NA | enzyme | NA | NA | 4.0e-02 | STAR | NA |
| PRR13 | NA | other | NA | NA | 4.0e-02 | THBS1 | NA |
| RBM25 | NA | other | NA | NA | 4.0e-02 | BCL2L1 | NA |
| TDP-665759 | NA | chemical reagent | NA | NA | 4.0e-02 | CDKN1A | NA |
| pharmacoperone IN3 | NA | chemical reagent | NA | NA | 4.0e-02 | STAR | NA |
| PSAT1 | 1.00e-01 | enzyme | NA | NA | 4.0e-02 | IRF1 | NA |
| NMS-873 | NA | chemical reagent | NA | NA | 4.0e-02 | MYC | NA |
| RPL21 | 5.40e-01 | other | NA | NA | 4.0e-02 | MYC | NA |
| RPLP0 | 1.00e-01 | other | NA | NA | 4.0e-02 | CCND1 | NA |
| CBP/CREB/CRTC2 | NA | complex | NA | NA | 4.0e-02 | TFEB | NA |
| kurarinone | NA | chemical reagent | NA | NA | 4.0e-02 | CFLAR | NA |
| diclofenac/hyaluronic acid | NA | chemical drug | NA | NA | 4.0e-02 | CFLAR | NA |
| solamargine | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L1 | NA |
| subditine | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| beta adrenergic receptor agonist | NA | chemical drug | NA | NA | 4.0e-02 | LEP | NA |
| atractylenolide I | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| CPS49 | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| picolog | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| flacourtia indica methanol extract | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| WJ9708012 | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| rocaglaol | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| 7,8-dihydroxy-4-methylcoumarin | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| N-[3-(trifluoromethyl)phenyl]retinamide | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| luffa echinata roxb fruit extract | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| gypenoside | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| pseudolaric acid B | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| alpinetin | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| bisindole-linked pyrrolo[2,1-c][1,4]benzodiazepine 5b | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| zuo-jin-wan | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L1 | NA |
| oltipraz metabolite M2 | NA | chemical reagent | NA | NA | 4.0e-02 | SREBF1 | NA |
| dianthus chinensis l. ethanol extract | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| SPI-112Me | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| melissa officinalis essential oil | NA | chemical reagent | NA | NA | 4.0e-02 | SREBF1 | NA |
| tetraacetyl-phytosphingosine | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| persea declinata (bl.) kosterm bark methanolic crude extract | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| nitidine | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| (+)-terpinen-4-ol | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| korean red ginseng extract | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| uncarinic acid E | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| NCGC00184710 | NA | chemical reagent | NA | NA | 4.0e-02 | PDK4 | NA |
| miR-135a mimic | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| hydroxyaminoindan | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| aloin | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| morusin | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | BCL2L1 | NA |
| H9 extract | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| droxinostat | NA | chemical reagent | NA | NA | 4.0e-02 | CFLAR | NA |
| let-7c mimic | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| licochalcone E | NA | chemical reagent | NA | NA | 4.0e-02 | SREBF1 | NA |
| licochalcone A | NA | chemical reagent | NA | NA | 4.0e-02 | SREBF1 | NA |
| raddeanin A | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| arsenic trichloride | NA | chemical reagent | NA | NA | 4.0e-02 | GADD45A | NA |
| MPT0G009 | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| fungal taxol | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| 1-benzyl-2-phenylbenzimidazole | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| AB1 | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L1 | NA |
| EAPB0203 | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| tinostamustine | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L1 | NA |
| zinc-citrate | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| amurensin G | NA | chemical reagent | NA | NA | 4.0e-02 | CFLAR | NA |
| 6-azidomethyl-1-hydroxy-3,8-dimethoxy-9,10-anthraquinone | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| cardiotoxin III | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| deoxyapoaranotin | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| acetylapoaranotin | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| acetylaranotin | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| JOT01006 | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| 4-(3’,5’-dimethoxybenzyloxy)-6-methoxyquinolin-2(1H)-one | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| TL-77 | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| 8-hydrocalamenene | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| farnesiferol C | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | BCL2L1 | NA |
| hederagenin | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| pien tze huang methanol extract | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| MAPK substrate-4 | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| 2,2-dichloroacetophenone | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| mansonone E | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| liriope platyphylla root part extract | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| 24-methylenecycloartanyl ferulate | NA | chemical reagent | NA | NA | 4.0e-02 | PPARG | NA |
| bornyl caffeate | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| AUH-6-96 | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| MPT0B169 | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| (-)-gossypol-enriched cottonseed oil | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| heteronemin | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| procyanidin B2-3’-O-gallate | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| sun ginseng extract | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| procyanidin B2-3,3’-di-O-gallate | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2L1 | NA |
| renin-angiotensin-aldosterone system blocking agent | NA | chemical drug | NA | NA | 4.0e-02 | AGT | NA |
| SAIT301 | NA | biologic drug | NA | NA | 4.0e-02 | BCL2L1 | NA |
| dexamethasone/tobramycin | NA | chemical drug | NA | NA | 4.0e-02 | TLR2 | NA |
| 3-mercaptopicolinic acid | NA | chemical drug | NA | NA | 4.0e-02 | NR3C1 | NA |
| 4,4’-diaminodiphenylmethane | NA | chemical toxicant | NA | NA | 4.0e-02 | CXCL10 | NA |
| BMS-275183 | NA | chemical drug | NA | NA | 4.0e-02 | THBS1 | NA |
| mitoguazone | NA | chemical drug | NA | NA | 4.0e-02 | ITGAL | NA |
| guanethidine | NA | chemical drug | NA | NA | 4.0e-02 | STAR | NA |
| IPI 493 | NA | chemical drug | NA | NA | 4.0e-02 | MET | NA |
| SU6657 | NA | chemical drug | NA | NA | 4.0e-02 | MYC | NA |
| diisopropanolnitrosamine | NA | chemical toxicant | NA | NA | 4.0e-02 | CDKN1A | NA |
| sulfaphenazole | NA | chemical drug | NA | NA | 4.0e-02 | CCND1 | NA |
| niravoline | NA | chemical reagent | NA | NA | 4.0e-02 | ADH1C | NA |
| remikiren | NA | chemical drug | NA | NA | 4.0e-02 | AGT | NA |
| melarsoprol | NA | chemical drug | NA | NA | 4.0e-02 | BCL2 | NA |
| Ro 20-1724 | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1 | NA |
| tetracaine | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L1 | NA |
| GS-626510 | NA | chemical reagent | NA | NA | 4.0e-02 | MYC | NA |
| N-(2,4-dimethoxybenzyl)-2,3-dichloromaleimide | NA | chemical reagent | NA | NA | 4.0e-02 | MYC | NA |
| NSC 126405 | NA | chemical reagent | NA | NA | 4.0e-02 | CDKN1A | NA |
| BRL 26830 | NA | chemical drug | NA | NA | 4.0e-02 | ADRB3 | NA |
| p-cuminaldehyde | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | BCL2L1 | NA |
| Laminin 511 | NA | complex | NA | NA | 4.0e-02 | NOG | NA |
| triazolam | NA | chemical drug | NA | NA | 4.0e-02 | PER1 | NA |
| sodium 2-((6Z,15Z)-20-hydroxyicosa-6,15-dienamido)acetate | NA | chemical reagent | NA | NA | 4.0e-02 | AGT | NA |
| ACS-1 | NA | chemical reagent | NA | NA | 4.0e-02 | MYC | NA |
| naftifine | NA | chemical drug | NA | NA | 4.0e-02 | SQLE | NA |
| bisindolylmaleimide III | NA | chemical - kinase inhibitor | NA | NA | 4.0e-02 | CFLAR | NA |
| anti-miR-302d | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1 | NA |
| anti-miR-302c inhibitor | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1 | NA |
| beta-penta-O-galloyl-glucose | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | CCND1 | NA |
| sodium hypochlorite | NA | chemical drug | NA | NA | 4.0e-02 | APEX1 | NA |
| BCR-JAK2 | NA | fusion gene/product | NA | NA | 4.0e-02 | BCL2L1 | NA |
| BRD4-NUTM1 | NA | fusion gene/product | NA | NA | 4.0e-02 | MYC | NA |
| AuNP@PEG@e14a2 | NA | chemical reagent | NA | NA | 4.0e-02 | BCL2 | NA |
| STAT3 inhibitor IX | NA | chemical reagent | NA | NA | 4.0e-02 | HAS2 | NA |
| XMD885 | NA | chemical drug | NA | NA | 4.0e-02 | MYC | NA |
| GTF2I-RARA | NA | fusion gene/product | NA | NA | 4.0e-02 | RNF8 | NA |
| MID-1 | NA | chemical reagent | NA | NA | 4.0e-02 | IRS1 | NA |
| anti-miR-32 inhibitor | NA | chemical reagent | NA | NA | 4.0e-02 | KLF4 | NA |
| SU11333 | NA | chemical drug | NA | NA | 4.0e-02 | MYC | NA |
| PF-4800567 | NA | chemical drug | NA | NA | 4.0e-02 | MYC | NA |
| chymostatin | NA | chemical - protease inhibitor | NA | NA | 4.0e-02 | AGT | NA |
| NCB-0846 | NA | chemical drug | NA | NA | 4.0e-02 | JUN | NA |
| pepleomycin | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L1 | NA |
| tetra(4-N-methylpyridyl)porphine | NA | chemical reagent | NA | NA | 4.0e-02 | MYC | NA |
| SMAD3-EP300 | NA | complex | NA | NA | 4.0e-02 | SERPINE1 | NA |
| 3-methoxyapigenin | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | MYC | NA |
| ipratropium | NA | chemical drug | NA | NA | 4.0e-02 | VIP | NA |
| TEI-F00806 | NA | chemical - protease inhibitor | NA | NA | 4.0e-02 | AGT | NA |
| baccatin III | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | MYC | NA |
| 2-methoxy-5-(2’,3’,4’-trimethoxyphenyl)-2,4,6-cycloheptatrien-1-one | NA | chemical reagent | NA | NA | 4.0e-02 | JUN | NA |
| iodine-131 | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L1 | NA |
| 10-hydroxydecanoic acid | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | IRF1 | NA |
| agar | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | RBM3 | NA |
| dihydroxyacetone | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | NR3C1 | NA |
| miR-424-5p inhibitor | NA | chemical reagent | NA | NA | 4.0e-02 | WEE1 | NA |
| 6alpha-fluorotestosterone | NA | chemical toxicant | NA | NA | 4.0e-02 | BCL2 | NA |
| RO5256390 | NA | chemical reagent | NA | NA | 4.0e-02 | IRS2 | NA |
| NSC 228155 | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1 | NA |
| NACHR | NA | group | NA | NA | 4.0e-02 | CCND1 | NA |
| NR2E1 | 4.00e-02 | ligand-dependent nuclear receptor | NA | NA | 4.0e-02 | CCND1,CDKN1A,MYC,TMPRSS2 | NA |
| EIF2B5 | 4.00e-02 | translation regulator | NA | NA | 4.0e-02 | ATF4,MYC,P4HA1,PPP1R15B | NA |
| MDM4 | 3.60e-01 | transcription regulator | NA | NA | 4.0e-02 | AXIN2,CDKN1A,EN1,LGALS3 | NA |
| mir-31 | NA | microRNA | NA | NA | 4.0e-02 | EGLN3,FGF10,MET,SATB2 | NA |
| CFLAR | 6.50e-01 | other | NA | NA | 4.0e-02 | BCL2L1,CDKN1A,CFLAR,CSF3 | NA |
| dithiothreitol | NA | chemical reagent | NA | NA | 4.0e-02 | CCND1,GADD45A,MYC,TLR2 | NA |
| GPX1 | -1.00e-01 | enzyme | NA | NA | 4.0e-02 | BCL2,CCL4,CXCL10,FADD,PRDX6 | NA |
| 12(S)-hydroxyeicosatetraenoic acid | NA | chemical - endogenous non-mammalian | NA | NA | 4.0e-02 | PAG1,PPARG | NA |
| L-proline | NA | chemical - endogenous mammalian | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| N-Cadherin | NA | group | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| Y-320 | NA | chemical reagent | NA | NA | 4.0e-02 | CXCL10,CXCL11 | NA |
| rhodamine 6G | NA | chemical toxicant | NA | NA | 4.0e-02 | BCL2,CCND1 | NA |
| CENPN | -3.00e-02 | other | NA | NA | 4.0e-02 | HK2,MYC | NA |
| saponaria officinalis extract, hexane sub-fraction 1 | NA | chemical reagent | NA | NA | 4.0e-02 | CD38,CXCL10 | NA |
| pasireotide | NA | biologic drug | NA | NA | 4.0e-02 | BMPR2,SMAD7 | NA |
| 2-amino-5-azotoluene | NA | chemical toxicant | NA | NA | 4.0e-02 | CYP2B6,MYC | NA |
| PPT1 | 9.00e-02 | enzyme | NA | NA | 4.0e-02 | CCL4,CXCL10 | NA |
| EIF4A3 | 4.90e-01 | enzyme | NA | NA | 4.0e-02 | BCL2L1,CCND1 | NA |
| GPAT3 | 2.60e-01 | enzyme | NA | NA | 4.0e-02 | PPARG,SREBF1 | NA |
| Meg3 | NA | other | NA | NA | 4.0e-02 | HK2,MYC | NA |
| SLC39A14 | 5.60e-01 | transporter | NA | NA | 4.0e-02 | ATF4,SREBF1 | NA |
| CHCHD5 | -2.60e-01 | other | NA | NA | 4.0e-02 | PPARG,SREBF1 | NA |
| NRAD1 | NA | other | NA | NA | 4.0e-02 | BCL2,MET | NA |
| PVT1 | NA | other | NA | NA | 4.0e-02 | CCND1,MYC | NA |
| HERC2 | 1.00e-02 | enzyme | NA | NA | 4.0e-02 | PYCARD,USP16 | NA |
| EHD2 | 1.80e-01 | other | NA | NA | 4.0e-02 | PPARG,SREBF1 | NA |
| SULT2B1 | 6.00e-02 | enzyme | NA | NA | 4.0e-02 | BCL2,MYC | NA |
| Lefty | NA | group | NA | NA | 4.0e-02 | CDKN1A,FOXO1 | NA |
| TAF1C | 1.20e-01 | transcription regulator | NA | NA | 4.0e-02 | IRF6,OVOL1 | NA |
| Proinsulin | NA | group | NA | NA | 4.0e-02 | FOXO1,NFATC1 | NA |
| GSK0660 | NA | chemical reagent | NA | NA | 4.0e-02 | PDK4,THBS1 | NA |
| evofosfamide | NA | chemical drug | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| BAG6 | 1.00e-02 | enzyme | NA | NA | 4.0e-02 | CDKN1A,SERPINE1 | NA |
| NFE2L3 | -1.20e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A,RAB27A | NA |
| SLC25A4 | 8.00e-02 | transporter | NA | NA | 4.0e-02 | BCL2L1,BIRC3 | NA |
| BANP | -1.51e+00 | other | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| mir-190 | NA | microRNA | NA | NA | 4.0e-02 | CCND1,MYC | NA |
| miR-541-5p (and other miRNAs w/seed AAGGAUU) | NA | mature microRNA | NA | NA | 4.0e-02 | CCND1,MYC | NA |
| RGS19 | -1.00e-01 | enzyme | NA | NA | 4.0e-02 | AXIN2,MYC | NA |
| STRN | -1.50e-01 | other | NA | NA | 4.0e-02 | NR3C2,SGK1 | NA |
| CYSLTR1 | -9.70e-01 | G-protein coupled receptor | NA | NA | 4.0e-02 | BCL2,NFATC1 | NA |
| FEM1A | 2.40e-01 | transcription regulator | NA | NA | 4.0e-02 | CCL4,CXCL10 | NA |
| SUMO1P3 | NA | other | NA | NA | 4.0e-02 | CCND1,MYC | NA |
| DLC1 | 3.00e-02 | other | NA | NA | 4.0e-02 | S100A10,SERPINE1 | NA |
| FALEC | NA | other | NA | NA | 4.0e-02 | BTG2,CDKN1A | NA |
| PPM1B | -4.00e-02 | phosphatase | NA | NA | 4.0e-02 | CEBPD,PLAGL1 | NA |
| AATF | -5.00e-02 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A,JUN | NA |
| EFEMP1 | 1.50e-01 | enzyme | NA | NA | 4.0e-02 | SERPINE1,SMAD7 | NA |
| LPA | NA | other | NA | NA | 4.0e-02 | NR3C1,SERPINE1 | NA |
| TRIM33 | 2.50e-01 | transcription regulator | NA | NA | 4.0e-02 | MYC,SERPINE1 | NA |
| CLTC | 1.40e-01 | other | NA | NA | 4.0e-02 | CDKN1A,KDR | NA |
| CUL1 | 3.20e-01 | enzyme | NA | NA | 4.0e-02 | IRS1,MYC | NA |
| NINJ1 | -1.10e-01 | other | NA | NA | 4.0e-02 | AXIN2,MYC | NA |
| MAD2L1 | -5.40e-01 | other | NA | NA | 4.0e-02 | BCL2,LRIG1 | NA |
| TDG | 2.00e-01 | enzyme | NA | NA | 4.0e-02 | APEX1,MYC | NA |
| DKC1 | 3.00e-02 | enzyme | NA | NA | 4.0e-02 | FGF2,SERPINE1 | NA |
| SUPT5H | 1.40e-01 | transcription regulator | NA | NA | 4.0e-02 | CDKN1A,MEIS2 | NA |
| BLM | 6.80e-01 | enzyme | NA | NA | 4.0e-02 | CDKN1A,IFI44L | NA |
| ATRX | 8.00e-02 | transcription regulator | NA | NA | 4.0e-02 | NFKB2,RELB | NA |
| BLACAT1 | NA | other | NA | NA | 4.0e-02 | CCND1,MYC | NA |
| TSPO | 1.00e-01 | transmembrane receptor | NA | NA | 4.0e-02 | BCL2,STAR | NA |
| SULF1 | -3.10e-01 | enzyme | NA | NA | 4.0e-02 | CCND1,NOG | NA |
| RACGAP1 | -6.00e-02 | transporter | NA | NA | 4.0e-02 | CDKN1A,JUN | NA |
| Duxbl1 | NA | transcription regulator | NA | NA | 4.0e-02 | OAS2,Oasl2 | NA |
| RHOC | -2.00e-01 | enzyme | NA | NA | 4.0e-02 | CDKN1A,GLUL | NA |
| CCL-34 | NA | chemical reagent | NA | NA | 4.0e-02 | CD8A,CXCL10 | NA |
| ULBP1 | NA | transmembrane receptor | NA | NA | 4.0e-02 | CCL4,CD83 | NA |
| Gm20703 | NA | other | NA | NA | 4.0e-02 | CXCL10,GBP5 | NA |
| perifosine | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A,CFLAR | NA |
| FM19G11 | NA | chemical reagent | NA | NA | 4.0e-02 | EGLN3,EPAS1 | NA |
| isoniazid | NA | chemical drug | NA | NA | 4.0e-02 | FLT3LG,TRPC3 | NA |
| CHS-828 | NA | chemical drug | NA | NA | 4.0e-02 | LRIG1,PROM1 | NA |
| pranlukast | NA | chemical drug | NA | NA | 4.0e-02 | BCL2,CYSLTR1 | NA |
| vandetanib | NA | chemical drug | NA | NA | 4.0e-02 | CCND1,KDR | NA |
| Pi3k class I | NA | complex | NA | NA | 4.0e-02 | ACLY,MYC | NA |
| ETV6-NTRK3 | NA | fusion gene/product | NA | NA | 4.0e-02 | Igtp,Oasl2 | NA |
| cinnamon powder | NA | chemical reagent | NA | NA | 4.0e-02 | IRS1,IRS2 | NA |
| N-methyl-3,4-methylenedioxyamphetamine | NA | chemical drug | NA | NA | 4.0e-02 | BCL2L1,Mt1 | NA |
| levofloxacin | NA | chemical drug | NA | NA | 4.0e-02 | CDKN1A,HAS2 | NA |
| artemisinin | NA | chemical drug | NA | NA | 4.0e-02 | CCND1,CDKN1A | NA |
| pyrogallol | NA | chemical toxicant | NA | NA | 4.0e-02 | JUN,VIP | NA |
| alpha-tocopherol succinate | NA | chemical drug | NA | NA | 4.0e-02 | BCL2,FGF2 | NA |
| tosyllysine chloromethyl ketone | NA | chemical - protease inhibitor | NA | NA | 4.0e-02 | IRF1,NFKBIA | NA |
| TMSB4 | NA | group | NA | NA | 5.0e-02 | ITGA1,SERPINE1,TRAF6 | NA |
| LRBA | 1.40e-01 | other | NA | NA | 5.0e-02 | CXCL10,FOXO1,FOXO3 | NA |
| PBRM1 | 3.20e-01 | other | NA | NA | 5.0e-02 | CDKN1A,CXCL10,IGFBP4 | NA |
| harmine | NA | chemical - endogenous non-mammalian | NA | NA | 5.0e-02 | BCL2,BCL2L1,NFATC1 | NA |
| S100B | 2.90e-01 | other | NA | NA | 5.0e-02 | CDKN1A,JUN,MYC | NA |
| MIR101 | NA | group | NA | NA | 5.0e-02 | BCL2,MET,MITF | NA |
| ponesimod | NA | chemical drug | NA | NA | 5.0e-02 | HAS2,SERPINE1,THBS1 | NA |
| SLC29A1 | -7.00e-02 | transporter | NA | NA | 5.0e-02 | CDKN1A,GADD45A,TP53INP1 | NA |
| CSF3R | -9.00e-01 | transmembrane receptor | NA | NA | 5.0e-02 | CISH,CSF3R,MYC | NA |
| BIRC2 | 2.00e-01 | enzyme | NA | NA | 5.0e-02 | BIRC3,CSF3,NFATC1 | NA |
| PDCD4 | -4.10e-01 | other | NA | NA | 5.0e-02 | JUN,LOX,MYC | NA |
| PLIN1 | 4.00e-02 | other | NA | NA | 5.0e-02 | ACACB,CIDEC,LEP | NA |
| DBP | -1.49e+00 | transcription regulator | NA | NA | 5.0e-02 | ADH1C,AGT,PER1 | NA |
| PCBP2 | -4.00e-02 | other | NA | NA | 5.0e-02 | CDKN1A,CSF3R,MYC | NA |
| FDFT1 | -2.40e-01 | enzyme | NA | NA | 5.0e-02 | FDPS,SQLE,SREBF1 | NA |
| Cux1 | NA | transcription regulator | NA | NA | 5.0e-02 | CD8A,CXCL10,Tchh | NA |
| SESN2 | 4.30e-01 | enzyme | NA | NA | 5.0e-02 | ATF4,BCL2,THBS1 | NA |
| tomatidine | NA | chemical - endogenous non-mammalian | NA | NA | 5.0e-02 | EIF2S2,NFATC1,SLC6A9 | NA |
| TPCA-1 | NA | chemical drug | NA | NA | 5.0e-02 | BACH2,MYC,TRAF1 | NA |
| MR-409 | NA | chemical reagent | NA | NA | 5.0e-02 | CCL24,CREB3L2,EPAS1 | NA |
| dichlororibofuranosylbenzimidazole | NA | chemical toxicant | NA | NA | 5.0e-02 | CDKN1A,MYC,SREBF1 | NA |
| acadesine | NA | chemical drug | NA | NA | 5.0e-02 | CDKN1A,CYP2B6,SREBF1 | NA |
| Hbb-b2 | NA | other | NA | NA | 5.0e-02 | CXCL10,FTL,IL2RB,TFRC,TLR2 | NA |
| IFNLR1 | -7.00e-02 | transmembrane receptor | NA | NA | 5.0e-02 | CCL4,CXCL10,MYC,THBS1,TLR2 | NA |
| STAT2 | -2.80e-01 | transcription regulator | NA | NA | 5.0e-02 | BCL2,CXCL10,Ifi47,IRF1,OAS2,Oasl2 | NA |
| TRB | NA | transmembrane receptor | NA | NA | 5.0e-02 | BCL2,CD8A,CDKN1A,NT5E | NA |
| urethane | NA | chemical toxicant | NA | NA | 5.0e-02 | CCND1,CDKN1A,KDR,MYC | NA |
| ceramide | NA | chemical - endogenous mammalian | NA | NA | 5.0e-02 | BCL2,CFLAR,JUN,MYC | NA |
Adipose %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S12. Ingenuity upstream regulators predicted to have similar activatory or inhibitory effect to ozone in Adipose - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))read_excel("../input_files/Upstream/Muscle_upstream analysis.xls")%>% row_to_names(row_number=1) -> Muscle## New names:
## • `` -> `...2`
## • `` -> `...3`
## • `` -> `...4`
## • `` -> `...5`
## • `` -> `...6`
## • `` -> `...7`
## • `` -> `...8`
## • `` -> `...9`as.numeric(Muscle$`Activation z-score`) -> Muscle$`Activation z-score`
Muscle <- Muscle[order(-Muscle$`Activation z-score`),]
as.numeric(Muscle$`Expr Log Ratio`) -> Muscle$`Expr Log Ratio`
as.numeric(Muscle$`p-value of overlap`) -> Muscle$`p-value of overlap`
Muscle %>%
mutate(
`Expr Log Ratio`=format(round(`Expr Log Ratio`,2),nsmall=2,scientific=TRUE),
`Activation z-score`=format(round(`Activation z-score`,2),nsmall=2,scientific=TRUE),
`p-value of overlap`=format(round(`p-value of overlap`,2),nsmall=2,scientific=TRUE)) %>%
kable(caption = "Supplementary Table S8. Ingenuity upstream regulators predicted to have similar activatory or inhibitory effect to ozone in Muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(1:8,bold=ifelse(is.na(Muscle$`Predicted Activation State`),F,T),color= ifelse(is.na(Muscle$`Predicted Activation State`),"gray",ifelse(Muscle$`Predicted Activation State` == "Inhibited","#40004B","#00441B"))) %>%
scroll_box(width = "1200px", height = "500px")| Upstream Regulator | Expr Log Ratio | Molecule Type | Predicted Activation State | Activation z-score | Flags | p-value of overlap | Target Molecules in Dataset | Mechanistic Network |
|---|---|---|---|---|---|---|---|---|
| SB203580 | NA | chemical drug | Activated | 7.40e+00 | NA | 0.0e+00 | ACTA2,ADAMTS8,ADAMTS9,ADIPOQ,ADRB2,ANKRD55,ANXA1,AQP4,ARG1,ARHGDIB,ATF3,BCL2L11,BDNF,BMP4,BPGM,C3,C3AR1,Ccl2,Ccl7,CCND1,CCRL2,CD109,CD200,CD28,CD47,CD83,CD86,CDH1,CDH2,CDK5R1,CDKN1A,CEACAM1,CEBPD,CIITA,CLDN1,COBL,COL1A1,COL3A1,CREB1,CRP,CRYAB,CST7,CTSH,CTSK,CX3CL1,CX3CR1,CXCL10,CYP1B1,CYP26B1,DCHS1,DUOX2,DUSP1,EDNRB,EGF,EGR1,ELOVL7,EMP2,F2RL3,F3,FN1,FOXO1,GADD45A,GBP2,GBP4,GLRX,GPI,GPR88,Gsta4,GZMB,HAS2,HAS3,HIF1A,ICAM1,IER3,IFIT1,IL1RN,IL2RA,IRF1,ISG15,ITGA4,ITGB3,JUND,KCTD1,KDR,LIMS1,LMO2,LMOD1,MAPK14,MAT2A,MITF,MMP2,MORC4,MSTN,MX1,MYF5,MYOCD,MYOD1,MYOG,NFKBIA,NKD2,NOX4,NPR1,NR4A1,NR4A3,OCLN,OLR1,OPTN,P2RX2,PALLD,PDGFB,PDGFRA,PENK,PHLDB2,PLA1A,PLAT,PPARD,PPARG,PPARGC1B,PRDX1,PRRG4,PTGES,PTGS2,REL,RETN,RGS7,RIPK2,RND1,RUNX1,RUNX2,S100A10,SELE,SELP,SERPINB9,SERPINE1,SERPING1,SGK1,SLC15A3,SLC20A1,SLC2A1,SLC35D1,SMYD1,SNAI1,SOCS3,SOX7,SPARC,SPP1,STAR,STAT1,TAGLN,TFPI2,TGFB1,THBS1,TIMP1,TLR2,TLR4,TMCC1,TNFAIP6,TNFRSF11B,TNFSF8,TOX,TP63,TRADD,TRPC6,TRPV1,TWIST1,UCP3,VCAM1,VEGFC,VIM,WLS,XYLT1 | 1239 (14) |
| Alpha catenin | NA | group | Activated | 6.46e+00 | bias | 0.0e+00 | ADAM33,ADAMTS1,ADAMTS2,ADAMTS5,AXIN2,BCL2L1,BCL3,BGN,BIRC3,C1QTNF2,C1QTNF3,CDH11,COL1A1,COL3A1,COL5A1,COL5A2,COL6A3,CXCL10,CXCL12,EGFL6,ELK3,ELN,ENG,EPHA3,FMNL2,FSTL1,GAP43,IGF1,IGFBP4,IGFBP6,IGFBP7,IL2RG,IRF1,ITGA5,LAMA2,LAMA4,LEF1,LUM,LYN,MMP19,MMP2,NFKBIA,NKD1,PDGFRA,PTGS2,PTX3,SELE,SGK1,SNAI1,SOCS3,STEAP2,THBS2,TIMP1,TNC,TNFAIP2,TNFAIP6,TSPAN8,TWIST1,TWIST2,VCAM1,VIM,WIPF1,ZEB2 | 1464 (19) |
| TREX1 | 3.70e-01 | enzyme | Activated | 6.12e+00 | bias | 0.0e+00 | ACSL1,B2M,BANK1,CASP1,CASP8,CD44,CD47,CD86,CDKN1A,CFB,CFH,CSF1,CXCL10,DHX58,DTX3L,EPSTI1,FCGR1A,GBP4,GBP5,HERC6,IFI16,IFI44,IFI44L,IFIH1,IFIT1,IFITM3,IKBKE,IL33,IRF1,IRF4,ISG15,LGALS9B,MAVS,MOV10,MX1,NCOA7,NLRP3,NUDT4,OAS3,OASL,PANX1,PARP14,PARP9,PLA2G4A,PLPP3,RASSF4,RSAD2,RTP4,S100A6,SIRT2,SP110,STAT1,TLR4,UBA7,UBE2L6,USP18,VCAM1,ZC3HAV1 | 628 (14) |
| ETV6-RUNX1 | NA | fusion gene/product | Activated | 5.96e+00 | NA | 0.0e+00 | ABCG1,ABLIM1,ABR,ACVR1B,ADCY7,ALOX5,ANO1,ANTXR2,ARHGAP24,ARHGAP4,ARHGEF10,BCL11A,BCL3,CARD11,CD44,CD48,CD83,CDC42EP3,CDH2,CFL1,CLIC1,CORO1A,CSK,CXXC5,CYBA,CYBB,CYSLTR1,DCHS1,DDIT4,DLL1,ELF4,EMP3,ENG,FCGRT,FGD2,FGFR1,FSCN2,FTSJ3,GBP2,GCH1,GIMAP4,GZMB,ICAM1,ID2,IER3,IFI16,IFIH1,IFIT1,IL15RA,IL7,IRF1,IRF3,IRF4,IRF5,IRF8,ISG15,ITGA4,ITGAL,ITGB2,ITM2C,JAK3,JUND,KIF5C,KLF6,LAT2,LCP2,LGALS1,LYN,MME,MMP2,MRPL41,NAA10,NCK2,NEDD4L,NEK6,NMI,PCDH18,PIK3C2B,POU2F2,PROM1,PSMD9,PTPRC,RAC2,RASAL3,RASGRP2,RFX1,RGL1,RNF144A,ROCK1,RSAD2,S100A4,SDK2,SIPA1,SMAD7,SORBS2,SPP1,STAT1,STAT6,STMN1,STX11,SWAP70,TACC2,TBC1D10C,TDRD1,TDRD7,TGFB1,TLR4,TMEM260,TNFAIP8L2,TNFRSF10A,TNK2,TRIM7,UBE2L6,ZBTB20 | 594 (7) |
| IRF2BP2 | 6.60e-01 | transcription regulator | Activated | 5.82e+00 | bias | 0.0e+00 | 9930111J21Rik1/Gm12185,ANO4,BCL2A1,C5AR1,CASP1,Casp12,CCR1,CD180,CD53,Clec4a3,CSF2RB,CXCL13,CYP1B1,CYSLTR1,CYTIP,DNASE1L3,FABP1,FCGR3A/FCGR3B,GBP5,GCNT1,GLDN,GSAP,HERC6,HLA-A,ID2,IFI16,IL2RG,LEPR,LILRB3,LPL,LY86,Milr1,MS4A6A,MYBL1,NR4A3,PLEK,SCIMP,SEC24D,SELP,SLA,TIMP1,Tlr13,TUBA8,VCAM1,ZNF705A | NA |
| CITED2 | -1.03e+00 | transcription regulator | Activated | 5.76e+00 | NA | 0.0e+00 | ARG1,ARHGEF3,ASAP3,B2M,BCL9,C15orf48,C3,C5AR1,Ccl2,CD86,CXCL10,CYBB,DNASE1L3,DTX3L,DUSP1,ENDOD1,ENTPD1,EXT1,F3,FCGR2B,FCGR3A/FCGR3B,FMNL2,FOXC2,FOXP3,GADD45B,GBP2,GBP4,GBP5,GNA13,GNG11,HCAR2,HIF1A,HLA-A,HOPX,ICAM1,IFI16,IFI44,Ifi47,IFIH1,IL17RA,IL1RN,IRF1,IRF8,ISG15,ITGA4,KIF5C,KLF6,LCP2,LGALS9B,LPL,MAX,MID1,MLKL,MRC1,NR5A1,OAS3,OASL,Oasl2,OTUD1,PARP14,PARP9,PDGFC,PFKFB3,PGK1,PITX2,PRRG4,RIPK2,RSAD2,RTP4,SCIMP,SEMA3C,SLC1A3,SLC38A2,STX3,TLR7,TMEM67,VEGFD,ZNF800 | 858 (14) |
| THZ1 | NA | chemical drug | Activated | 5.68e+00 | bias | 0.0e+00 | ACTA1,ADAMTS2,AEN,ANKRD1,ANXA1,ATF3,BACE2,BCL2L1,BGN,BIRC3,C15orf48,CCDC80,CILP,CLEC11A,COL12A1,COL14A1,COL1A1,COL3A1,CSRP2,CTHRC1,CYTIP,DDAH1,DKK3,DUSP10,EMP1,FBLN5,FBN1,Fcrls,FHL1,FMOD,FN1,FRZB,FSTL1,FXYD6,GADD45GIP1,GPR183,HSPA1A/HSPA1B,IGF1,LBP,LOX,LOXL1,LTBP2,LYST,MEOX1,MFAP5,MMP2,MTSS1,OLFML3,PAMR1,PCOLCE,PDGFRL,PMEPA1,PRELP,PTGIS,RAPH1,SDC1,SEMA3D,SERPINE1,SERPINF1,SFRP1,SFRP2,SLA,SRPX2,ST3GAL1,STAR,THBS1,THBS4,TIAM2,TIMP1,TMEM119,TMEM45A,TNFRSF8,TRERF1,VCAN | 1183 (9) |
| RNASEH2B | 7.00e-02 | other | Activated | 5.59e+00 | bias | 0.0e+00 | B2M,CASP1,CASP8,CD47,CDKN1A,CFB,CFH,CSF1,CXCL10,DHX58,EPSTI1,HERC6,IFI44,IFI44L,IFIH1,IFIT1,IFITM3,IL34,IL7,IRF1,IRF4,ISG15,MOV10,MX1,NCOA7,NLRP3,OAS3,PARP14,PARP9,PTGS2,PYCARD,RSAD2,RTP4,S100A6,SIRT2,SP110,TLR4,UBA7,USP18,VCAM1 | NA |
| LY294002 | NA | chemical drug | Activated | 5.49e+00 | NA | 0.0e+00 | ABCA1,ACKR3,ACSM3,ACTA2,ADAM17,ADAMTS1,ADH1C,ADRB2,AGL,ANGPT2,ANPEP,ART3,ATF3,BCL2L1,BCL2L11,BCL6,BDNF,BHLHE40,BIRC3,BRAP,BRCA2,BTK,BUB1B,CA9,Cald1,CASP3,Ccl2,CCNA2,CCND1,CCND2,CCR1,CD36,CD44,CD74,CD83,CD86,CDH1,CDH2,CDK2,CDK5R1,CDK6,CDKN1A,CLCN3,CNR1,COL1A1,CP,CREM,CRP,CXCL10,CXCL16,DNASE1L3,DUSP1,DUSP6,EDIL3,EGR1,EGR2,EGR3,ENTPD1,ERBB3,ERCC1,Esrra,ETS1,F2R,F3,FEN1,FGF2,FLRT2,FN1,FOXC1,FOXC2,FOXO1,FRK,GCLC,GFAP,GPD1,GPD2,GPR183,GSR,Gsta4,HAS2,HERPUD1,HGF,HIF1A,HOXD4,ICAM1,IER3,IFRD2,IGF1,IGFBP5,IL17A,IL1RN,IL33,INHA,INHBB,INPP4B,IRF1,IRS1,IRS2,ITGA2B,ITGB3,ITGBL1,KLF10,L3MBTL1,LAMC2,LOXL1,MAF,MAP2,MAP2K4,MAT2A,MITF,MMP14,MMP2,MTHFD2,MYF5,MYOG,NFATC3,NFE2L2,NFKBIA,NR4A1,NR4A2,NR4A3,NR5A1,NTS,P2RY6,PGK1,PHLDA1,PIK3R1,PLA2G2A,PLK2,PLPP3,PPARD,PPARG,PRDX1,PTGS2,PTN,PTPRJ,PTX3,Raet1d/Raet1e,RASSF2,RBL1,RETN,RGS2,RND3,RUNX2,RXRG,SELP,SEMA3C,SERPINE1,SGK1,SLA,SLC1A1,SLC2A1,SLC38A3,SMC2,SNAI1,SNAI2,SNTB2,SOCS3,SPN,SPP1,SREBF1,SYK,TAGLN,TCF15,TFPI2,TGFB1,THBD,THBS1,TLR2,TNFRSF1B,TNFSF8,TOP2A,TOP3B,TP63,TPO,TYMS,VCAM1,VCAN,VEGFC,VIM,WNT5A,ZBTB16,ZFP36,ZFP36L2 | 1404 (15) |
| Irgm1 | 5.30e-01 | other | Activated | 5.47e+00 | bias | 0.0e+00 | B2M,BUB1,Ccl2,CCNA2,CXCL10,CXCL13,CXCL16,DHX58,GBP2,GBP4,GBP5,GBP7,HERC6,ID2,IFI16,IFI44,IFIH1,IFITM3,IRF1,ISG15,MKI67,MLKL,NCAPG,OAS3,OASL,Oasl2,RSAD2,SELP,STAT1,TLR2,USP18 | 949 (17) |
| triptolide | NA | chemical drug | Activated | 5.41e+00 | NA | 0.0e+00 | ACVRL1,AHR,AKAP12,APLN,APLNR,BCL2L1,CALCRL,CASP3,CAV1,CCR5,CDH1,CDKN1A,CXCL12,DACH1,DLC1,DPP4,DUSP1,EDNRB,EMP1,ENG,F2RL1,FBLN5,FBN1,GCLC,HGF,ICAM1,IER3,IL17A,IL17RD,ITGA1,ITGA2,ITGA6,ITPKB,KDR,KIT,KITLG,LAMA3,LEF1,MKI67,MMP19,NFE2L2,NPR1,OCLN,PDGFRA,PMP22,PTGS2,RASGRF2,RECK,SERPINB9,SOCS3,TBX5,TEK,TLR2,TLR4,UACA,UBE3A | 1229 (19) |
| miR-34a-5p (and other miRNAs w/seed GGCAGUG) | NA | mature microRNA | Activated | 5.34e+00 | bias | 0.0e+00 | ACTA2,ATF3,AXIN2,AXL,CCND1,CCND2,CD47,CDK6,CDKN1A,COL1A1,CREB1,DLL1,DOCK8,DPYD,E2F2,E2F5,EFHD1,FCMR,FN1,GFRA1,GPR155,HAPLN3,ICAM1,IKBIP,ITGB3,JAG1,KLF4,LEF1,LGALS9B,MET,MYCN,NOTCH2,PLCB1,PPARG,PPM1H,PTCH1,PTPN7,SERPINB8,SLC18A2,SLC22A17,SLCO3A1,TAGLN,THBS1,TMC7 | 1470 (18) |
| aspirin | NA | chemical drug | Activated | 5.29e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACVRL1,ADRB2,AHR,AKAP12,APLN,APLNR,BCL2L1,BDNF,CALCRL,CAV1,Ccl2,CCND1,CD86,CDK2,CDKN1A,CRP,CSF1,CX3CL1,CXCL10,CXCR4,DACH1,DLC1,DPP4,EDNRB,EMP1,ENG,F2RL1,FBLN5,FBN1,GLI1,HGF,ICAM1,IER3,IL17RD,ITGA1,ITGA2,ITGA6,ITPKB,KDR,KIT,KITLG,LAMA3,LAMP2,MMP2,NCF1,NOX4,NPR1,OCLN,OLR1,PLA2G4A,PMP22,PPARD,PTGER3,PTGS2,RASGRF2,RECK,RHOA,SELP,SERPINB9,SOX7,TBX5,TEK,TGFB1,THBS1,TRPC3,VCAM1 | 1520 (18) |
| miR-124-3p (and other miRNAs w/seed AAGGCAC) | NA | mature microRNA | Activated | 5.07e+00 | bias | 0.0e+00 | ABHD5,AHR,AHRR,ALDH9A1,ANKRD27,ANXA8/ANXA8L1,ARHGAP29,ATL3,B4GALT1,BDNF,BTG3,CAV1,Ccl2,CDC14B,CDCA7L,CDK2,CDK6,CHP1,CHSY1,CPNE3,CYP1B1,DEPDC1,DNAJC1,DRAM1,E2F5,EGR1,ELF4,ELK3,ELOVL1,ELOVL5,ENDOD1,EYA4,FA2H,FAM104A,FAM177A1,FSTL1,GNAI3,GNG10,HDAC4,IFRD2,IQGAP1,JAG1,KLF15,LIMCH1,LITAF,LRRC1,MAN2A1,MAPK14,MDFIC,MYO10,NEK6,NEK9,NID1,OAF,PDLIM7,PGM1,POLR3G,PRKD1,PTPN12,RARG,RASSF5,RDH10,SERP1,SLC16A1,SLC17A5,SNAI2,SWAP70,TARBP1,TMBIM1,TMEM263,TSC22D4,TSKU,TTC7A,TUBB6,TWIST2,UHMK1,UHRF1,USP49,VSNL1,ZBED3,ZFP36L2,ZNF367 | NA |
| GRIN3A | -1.46e+00 | ion channel | Activated | 5.03e+00 | bias | 0.0e+00 | ADAM19,BDNF,BMP3,CAMK1D,CATSPERG,CD200,CNKSR2,CXXC4,DCN,ESRRG,ETV1,Fat4,Fn3k,GDA,GPD2,GPR176,HDAC9,HPSE,ITGA8,LGI1,LUM,MAL2,Mt1,MTHFD2,POPDC3,PTGS2,RCAN2,RNF152,ROBO2,SLC4A10,SLITRK1,SNCA,SNX16,SV2B,TACR3,THY1,TLL1,TMEFF1,TRHDE,TSPAN2,XK,ZNF180,ZNF25 | 271 (5) |
| Ttc39aos1 | NA | other | Activated | 5.01e+00 | bias | 0.0e+00 | ATP10A,BCL2A1,Ccl2,Ccl7,CXCL10,DHX58,DTX3L,GBP2,HEG1,IFI16,IFI44,IFIH1,IFIT1,IFITM3,IRF1,ISG15,MOV10,MSR1,OAS3,PARP14,PARP9,PYCARD,RNF213,RSAD2,RTP4,SERPINE1,SLC15A3,UBE2L6,USP18 | 581 (10) |
| MYCN | -1.95e+00 | transcription regulator | Activated | 4.87e+00 | NA | 0.0e+00 | ABCA1,ABCA7,ABCB9,ABCC3,ABCC4,ABCG4,ACTG1,ACTN4,ADAMTS1,ADAMTS5,ALDH1A1,ALDOA,B2M,BCL11A,BCL11B,BCL2L1,CAV1,CCND1,CCND2,CDH11,CDKN1A,CIITA,CITED2,CKAP4,COL18A1,COL1A1,COL5A2,COL8A1,DIRAS1,DKK3,DPYSL3,E2F2,E2F5,EEF1A1,EEF1D,EFNA5,EIF3C,EMP1,EZH2,FAU,FBN1,FBXO32,FKBP9,FN1,GAPDH,GATA4,HLA-A,ID2,IGFBP7,INHBA,ITGA2,ITGA3,LGALS1,LRRN1,MAT2A,MITF,MMP2,MRC2,MYCN,MYOM3,NCAM1,NUCB1,PDIA4,PDLIM1,PHGDH,PROM1,PTPRO,RAB3D,RBBP4,RCAN2,RELN,RPL17,RPL18,RPL22,RPL23,RPL28,RPL35,RPL37A,RPL6,RPS15,RPS16,RPS2,RPS24,RPS3,RUSC2,S100A10,SDC2,SERPINE1,SHOX2,SLC16A1,SLC16A7,SLC2A1,SLC38A2,SLIT3,SLITRK1,SORD,SPARC,TAGLN,TM6SF1,TMPRSS2,TUBB,VIM,ZEB2 | 1640 (22) |
| N-acetyl-L-cysteine | NA | chemical drug | Activated | 4.85e+00 | NA | 0.0e+00 | ACTA1,ACTA2,ADGRE1,ATP1A1,ATP6AP2,BACH1,BCL2A1,BCL2L1,BCL2L11,BIRC3,C3,CASP1,CASP3,CAV1,Ccl2,CCND1,CCND2,CCR5,CD36,CD86,CDH1,CDKN1A,COL1A1,CTSK,CXCL10,CXCL12,CXCR4,CYBA,CYBB,DDIT4,DUSP1,DUSP6,EDN1,EGR1,EIF2AK3,ESM1,FAM3B,FBXO32,FGF2,FOXO3,GAPDH,GCLC,GZMB,HAX1,HDC,HIF1A,HLA-DRA,ICAM1,IL2RA,ITGA4,LPL,LTB4R,MAP1LC3A,MAP1LC3B,MAPK14,MMP2,MRC1,MSR1,MYOCD,NCF2,NFE2L2,NFKBIA,NLRP3,PHGDH,PRKDC,PTGS2,PYCARD,RUNX2,SELE,SELP,SERPINE1,SLC16A1,SNAI1,SNCA,SPP1,TAGLN,TGFB1,THBD,TLR4,TNC,TNFRSF10A,TNFRSF8,TRIM63,TWIST1,VCAM1,VEGFC | 1489 (16) |
| SN-011 | NA | chemical reagent | Activated | 4.80e+00 | bias | 0.0e+00 | ACSL1,CDKN1A,CXCL10,DTX3L,FCGR1A,GBP4,GBP5,HERC6,IFI44,IFIH1,IFITM3,IKBKE,IRF1,ISG15,LGALS9B,MOV10,OAS3,OASL,RASSF4,RSAD2,RTP4,SP110,STAT1,UBA7,UBE2L6,USP18,ZC3HAV1 | NA |
| miR-1-3p (and other miRNAs w/seed GGAAUGU) | NA | mature microRNA | Activated | 4.75e+00 | bias | 0.0e+00 | ABHD11,ANPEP,ANXA2,ARHGAP29,AXL,BDNF,Calm1 (includes others),CDK14,CHST11,CHSY1,CLCN3,CNN3,CNOT6,CORO1C,CSRP1,CTSC,DNAJB1,EPB41L4B,FSTL1,G6PD,GCH1,GNPDA2,GNPNAT1,GPD2,HACD2,HACD3,HDAC4,IGF1,INPP5F,IP6K2,IQGAP3,Irx5,ITGB4,KLHL42,LASP1,MET,MOV10,MRC2,MTHFD2,NOTCH2,NRP1,OSBPL7,PDLIM7,POLA1,POLA2,POLR2K,PPIB,PREX1,PTPRF,PXYLP1,RBM28,SDC4,SERP1,SFXN1,SH2D4A,SHTN1,SLC25A22,SLC44A1,SPHK1,TAGLN2,THBS1,TMSB10/TMSB4X,TPPP,TWF1,UHMK1,UHRF1,UNC93B1,UST,UTRN,YWHAQ | NA |
| miR-199a-5p (and other miRNAs w/seed CCAGUGU) | NA | mature microRNA | Activated | 4.70e+00 | bias | 0.0e+00 | ACTA1,ACTG2,BGN,C3,CDH1,CDKN1A,CELSR1,COL1A1,CSTB,DCN,DDR1,ETS1,FN1,HIF1A,ISG15,ITGA1,ITGA3,ITGB3,ITGB4,JAG1,KLF4,LAMC2,MYOCD,MYRF,NECTIN1,NEDD9,PTGS2,RND1,RSAD2,TAGLN,TGFB1I1,TMPRSS2,WNT6,ZBTB16 | 799 (7) |
| FKBP10 | -7.70e-01 | enzyme | Activated | 4.64e+00 | bias | 0.0e+00 | APLN,BCL3,BGN,CHI3L1,CLEC11A,COL12A1,COL16A1,COL18A1,COL1A1,COL2A1,COL3A1,COL5A1,COL5A2,COL6A3,COL8A1,COL8A2,CSGALNACT1,EPHB2,GLI1,IGF1,IL1RL1,INHBA,LBP,MMP14,MMP2,MSTN,NOX4,PDPN,PLOD2,PTGS2,SERPINE1,SLC16A2,SNAI1,SOCS1,SPHK1,SPP1,THY1,TIMP1,TNFAIP6 | NA |
| IKZF1 | NA | transcription regulator | Activated | 4.64e+00 | NA | 0.0e+00 | ABCA9,ADAM19,ANTXR1,AXL,B2M,BCL2L1,BCL6,CAV1,CAV2,CCND2,CCR1,CD34,CDK6,CDKN1A,CISH,CITED2,CSF1,CYP7B1,DNM1,DTX1,DTX3L,DUSP5,EBF1,EIF2AK3,EIF4E3,EMP1,EPB42,EPSTI1,FGFR1,FKBP9,FLI1,FN1,FOXO1,FOXO3,G6PD,GPR68,HHATL,IFI16,IGF1,IGSF11,IL15RA,IL18R1,IL2RA,IL2RB,IRF4,ITGA2B,KIF23,KIT,KITLG,KLF4,LHFPL2,LILRB3,LMO2,LYN,MAN1C1,MAP2,MLXIP,MMP14,NCAM1,NFAT5,NLRP3,NRARP,OTUD1,POU2F2,PRKCQ,PROS1,PYGL,RAPGEF4,RASSF4,RHBDF2,RNF213,RTP4,RUNX1,RYR1,SELENOM,SEMA5A,SERPINH1,SLC27A3,SLC2A1,SPN,ST3GAL6,SULF2,TBC1D9,TLR4,TMEM119,TNFAIP8L2,TNNT2,UACA,UEVLD,VWF,WNT10B,ZDHHC9 | 1315 (17) |
| SPRY2 | -4.40e-01 | other | Activated | 4.58e+00 | NA | 0.0e+00 | ADAM17,ARG1,AXIN2,CAV1,CDKN1A,CFH,CLEC4A,CMKLR1,CXCL10,CXCR4,DUSP6,EPHB4,ETS1,ETV1,ETV5,FCER1G,G0S2,GLRX,GNG11,HIF1A,ID2,IL10RA,IL17A,IL2RG,IL33,ISG15,ITGA2,ITGB2,KIF5C,LAT2,LCP1,MAP4K1,MAP7,MET,MPZL2,MYCN,NR2F1,OCLN,PFKFB3,PGK1,PLVAP,PRDM1,PTGS2,RETN,SCN1B,SFTPB,SLC2A1,SPON1,SPP1,ST6GAL1,TLR8,TPH1 | 1464 (19) |
| RC3H1 | NA | enzyme | Activated | 4.57e+00 | NA | 0.0e+00 | CCL24,CD44,CLDN1,CXCL13,EDN1,IFI16,IFI44,IFI44L,IFIT1,IFITM3,IL17A,IRF1,ISG15,ITGAE,MX1,NRP1,OAS3,PARP9,RSAD2,SDC1,SPP1,STAT1,TNFRSF1B,TNFRSF4,WNT5A | 1282 (15) |
| dexmedetomidine | NA | chemical drug | Activated | 4.53e+00 | NA | 0.0e+00 | CASP3,Ccl2,CCNE2,CDK6,CDKN1A,COL1A1,COL6A6,CSF1,DDIT4,EGF,F2R,FGF2,FN1,HGF,HSP90AA1,ICAM1,IL7,ITGA2,ITGA3,ITGA5,ITGB3,ITGB4,LAMC2,OSMR,PTGS2,SPP1,THBS2,TLR2,TNC | 1510 (19) |
| SPDEF | 1.14e+00 | transcription regulator | Activated | 4.51e+00 | NA | 0.0e+00 | BIRC3,CD34,CDH11,CDH2,CDKN1A,COL13A1,COL16A1,COL1A1,COL4A6,COL5A1,COL5A2,COL6A3,DKK3,FGFR1,HIF1A,IL33,ITGA3,ITGA5,ITGA6,LASP1,LEF1,PTPRF,SDC1,SDC2,SERPINE1,SNAI2,STMN1,TGFB1,TNC,UCP3,VIM,WNT5A | 1446 (21) |
| TRIM24 | NA | transcription regulator | Activated | 4.51e+00 | NA | 0.0e+00 | CALB1,CNOT6,CSRP1,CXCL10,DHX58,EMB,EPSTI1,FAM110B,FBN1,FLRT3,GBP2,GBP4,GLUL,HERC6,IFI44,Ifi47,IFIH1,IL1R1,IRF1,ISG15,MOV10,MYH10,NMI,OASL,PACSIN3,PRKCQ,PRPS2,RTP4,SERPINE1,SOCS1,SPP1,STAT1,TGFBI,TLR2,UBA7,USP18 | 1392 (19) |
| IRGM | NA | enzyme | Activated | 4.47e+00 | bias | 0.0e+00 | B2M,CXCL10,DHX58,GBP4,IFI16,IFI44,IFI44L,IFIH1,IFIT1,IFITM3,IKBKE,ISG15,MAP3K6,MX1,NFKBIA,NINJ1,OAS3,OASL,RSAD2,SOCS3,STAT1,TNFAIP2,TNFAIP6,TRIM69,UBA7,UBE2L6,USP18 | 702 (10) |
| SOCS1 | 1.05e+00 | other | Activated | 4.46e+00 | NA | 0.0e+00 | A2M,ARG1,BCL2A1,BCL2L1,Ccl2,CCND1,CCND2,CD1D,CD200R1,CD44,CD86,CDK2,CDKN1A,CIITA,CISH,CXCL10,DUSP1,FCER1G,FKBP5,GBP5,H2-T24,ICAM1,IFI16,IFI44,Ifi47,IFIH1,IFIT1,IL17A,IL2RB,IRF1,IRS1,IRS2,ISG15,MX1,Oasl2,PTGS2,RALGDS,RSAD2,SELE,SNAI1,SOCS1,SOCS3,STAT1,STAT6,USP18,VCAM1 | 1066 (16) |
| diphenyleneiodonium | NA | chemical reagent | Activated | 4.46e+00 | NA | 0.0e+00 | ACTA2,ATF3,ATP6AP2,CASP1,Ccl2,COL1A1,EGR1,F3,FN1,GCLC,HIF1A,NFE2L2,NLRP3,NOX1,NOX4,PDE5A,PTGS2,PYCARD,SELE,SERPINE1,TGFB1,THBS2,TIMP1,TRPC6 | 1293 (15) |
| SMARCA5 | 1.50e-01 | transcription regulator | Activated | 4.45e+00 | NA | 0.0e+00 | AEN,AHR,ATP2B4,ATP8B4,B2M,BCL6,CACNA1E,CASP1,CCND2,CD44,CD53,CD93,CDH1,CDKN1A,CELSR1,CHD7,CLEC12A,CPA3,DTX1,ENC1,EPHB2,ESM1,FKBP5,FUCA1,GFRA1,GM2A,H2-T22,HLA-A,IGFBP4,IL2RA,KIT,LPAR6,LYN,MAST4,MPZL2,NINJ1,PHLDA1,PLCG2,PLK2,PLXND1,Pmaip1,RRAD,RTP4,SEMA4A,SLAMF1,SMOC1,SNX10,TIFA,TMEM176B,UNC93B1,VWCE,WDFY4 | 1085 (14) |
| FOXO3 | 1.32e+00 | transcription regulator | Activated | 4.38e+00 | NA | 0.0e+00 | ACTA2,ACVR1,AHR,ANGPT2,ANXA1,APLN,AQP4,BCL2L11,BCL6,BPGM,BTG1,BUB1B,CASP8,CAV1,CCND1,CCND2,CCNE2,CD44,CDC42EP3,CDH1,CDKN1A,CERS4,CHCHD4,CLDN1,CXCL10,CXCR4,DDIT4,DOK5,EDNRB,EGR1,EGR2,EIF4EBP1,ELOVL5,ELOVL7,ENO2,ENPEP,FBXO32,FMOD,FOXC1,FOXO1,FOXO3,FOXP3,FYN,GABARAPL1,GADD45A,GADD45B,GCLC,GLUL,GPX3,HIF1A,IER3,IFIH1,IGF1,IGFBP7,IKZF2,IL10RB,IL17A,IL1R1,INHBA,IP6K2,IRS1,IRS2,ITGB2,JAG1,KLF4,LCP2,LRAT,MAP1LC3A,MAP1LC3B,MAX,MBNL1,MCM7,MET,MKI67,MRC1,MSTN,Mt1,MTHFD2,MYOCD,MYOD1,NCAPG2,NFKBIA,NRP1,NRP2,NTN4,OPTN,PAWR,PDE3B,PLA2G2D,PLK1,PRCP,PRDM1,PRDX5,PRKAA2,PRKCD,PTPRB,PTPRC,Rcan1,RTN3,RUNX2,SERPINE1,SESN1,SGK1,SIX4,SKA1,SKP2,SLC1A4,SLC7A1,SMAD7,SNAI1,TAL1,TGFB1,TNFRSF1B,TP63,TRIM63,UBC,VCAM1,VIM | 1693 (21) |
| AMBRA1 | 3.20e-01 | other | Activated | 4.38e+00 | NA | 0.0e+00 | ADAMTS9,CCND1,CCND2,CCNE2,CDH2,CDKN1A,COL14A1,COL16A1,COL18A1,COL1A1,COL27A1,COL3A1,COL5A1,COL5A2,COL8A1,FAP,FN1,ITGA8,ITGB3,ITGB7,LOXL1,LOXL2,LOXL4,MMP14,MMP15,MMP2,SERPINE1,SMAD7,SNAI1,VIM | 1463 (20) |
| miR-17-5p (and other miRNAs w/seed AAAGUGC) | NA | mature microRNA | Activated | 4.31e+00 | bias | 0.0e+00 | ACTA2,ADAMTS5,ALDH1A3,BAMBI,BCL2L11,Ccl2,CCNA2,CCND1,CCND2,CCNE2,CD44,CDK2,CDK6,CDKN1A,CDKN2C,CREB1,E2F2,EGR2,HIF1A,IRAK2,MYLIP,OLFML1,PKD2,PPARG,RHOA,RUNX1,RUNX2,SLC1A3,TLR7,TP63,VIM | 1332 (15) |
| NR3C1 | -5.50e-01 | ligand-dependent nuclear receptor | Activated | 4.26e+00 | NA | 0.0e+00 | A2M,AATK,ABCA1,ABI1,ACTA2,ACTN2,ADH1C,AKTIP,AMIGO2,ANXA1,ARHGEF3,ATP1B1,B2M,BARD1,BCKDHA,BCL2L1,BCL2L11,BCL6,BDNF,BHLHE40,BIN1,BIRC3,BTG1,BTK,C1QTNF2,C1QTNF4,C1QTNF7,C1R,CARD6,CAV1,Ccl2,Ccl7,CCND1,CCR1,CCR5,CCRL2,CD47,CD83,CDC42EP3,CDKN1A,CEBPD,COL1A1,COL3A1,COL5A1,CORO1C,CRYAB,CSRNP1,CX3CR1,CXCL10,CXCR4,CYP27A1,DAD1,DAPK3,DDIT4,DNASE1L3,DPF2,DPP4,DUSP1,DYNLL1,EDN1,EGR1,EMP1,ENC1,EPB41L4B,ERRFI1,F2R,F2RL1,F3,FADD,FAM89B,FCER1G,FGD4,FKBP5,FN1,FOXO1,FOXO3,G6PD,GAB1,GADD45A,GADD45B,GAP43,GBP2,GLUL,GPR65,GPX3,GRIA2,GULP1,H6PD,HCAR2,HERPUD1,HIF1A,HNRNPU,HSD17B12,ICAM1,IDH1,IER3,IFIH1,IGF1,IGFALS,IKBKB,IL10RA,IL15RA,IL17A,IL33,INHBA,IP6K3,IRF1,IRF8,ISG15,ITGB2,JUND,KAT5,KLF9,LAD1,LGALS12,LOC259246 (includes others),LOX,LPIN1,LYST,MAGI3,MAL,MAP3K14,MAPK3,MAX,MSRB1,Mt1,Mt1m/Mt2A,NAV3,NFIL3,NFKBIA,NFKBIB,NLRC4,NLRP3,NOD2,NOTCH4,NR0B2,NRG2,OASL,OCLN,OLR1,PAWR,PAX3,PC,PDPN,PEA15,PER1,PFKFB3,PIK3R1,PIK3R3,PIM3,PLA2G4A,PLAGL1,PLAT,PLEKHF1,PLK2,PNMT,PNPLA2,PPARG,PPP3CA,PRKCB,PRKCD,PRKCE,PRKCI,PSMA6,PTGS2,PTP4A2,PYGL,RAPGEF4,RGS2,RIPK2,RNF38,ROCK1,RUNX2,SAP30BP,SELE,SELENOP,SEMA3C,SERPINB9,SERPINE1,SGK1,SGPP1,SIAH2,SLC19A2,SLC25A33,SLC2A5,SLC38A1,SLC7A6,SNAI1,SNAI2,SNCA,SPP1,STAT6,SUMO2,Tcf7,TGFB1,THBD,THBS1,TIMP1,TIPARP,TLR2,TLR5,TM2D2,TNFAIP2,TNFAIP6,TNFAIP8,TNFRSF10A,TNFRSF11B,TNFRSF1B,TNFRSF25,TNFRSF8,TP53BP2,TRAF5,UGCG,VCAM1,VIM,WDR37,WNT5A,ZFYVE28,ZNF48 | 1777 (19) |
| PD98059 | NA | chemical - kinase inhibitor | Activated | 4.20e+00 | NA | 0.0e+00 | ABCA1,ACOT7,ACTA2,ADIPOQ,AKAP12,ALDOA,AMD1,ANGPT2,ANKRD1,ANPEP,ANXA1,ATF3,ATP2A1,BCL2L1,BCL2L11,BCL6,BDH1,BDNF,BGN,C3,Cald1,CASP3,CAV1,Ccl2,CCNA2,CCND1,CCND2,CCNE2,CCR1,CD36,CD37,CD44,CD74,CD83,CD86,CDH1,CDH2,CDH3,CDK2,CDK5R1,CDKN1A,CEBPD,CMA1,COL1A1,COL3A1,CREB1,CREM,CRP,CSTF1,CTSH,CTSK,CXCL10,CXCR4,CYP1B1,DUSP1,DUSP5,DUSP6,E2F2,EDN1,EDNRB,EEF1A1,EGR1,EGR2,EGR3,EIF2AK3,ELN,EMP1,EMP3,ENG,ENO2,ENTPD1,ERRFI1,ETS1,F2R,F3,FAM171A1,FAM3B,FGF2,FKBP5,FN1,FOXC2,FOXP3,GADD45A,GAP43,GAS7,GPI,HAS2,HGF,HIF1A,ICAM1,IER3,IGF1,IL17A,IL1RN,IL2RA,ITGA2,ITGA2B,ITGA4,ITGB2,ITGB3,JUND,KLF15,KRT19,LAD1,LAMA3,LAMP2,LIPG,LPL,MAPK3,MAT2A,MB,MCM8,MET,MITF,MKI67,MMP14,MMP2,MSR1,MSTN,MYCN,MYF5,MYH7,MYOCD,MYOD1,MYOG,NFE2L2,NFKBIA,NINJ1,NOS1,NR4A1,NXN,OPCML,OSMR,PAWR,PC,PDGFB,PDGFRA,Peg3,PER1,PFKFB1,PHLDA1,PIK3R1,PLA1A,PLA2G4A,PLAGL1,PLAT,PPARD,PPARG,PTAFR,PTGES,PTGS2,PTX3,RECK,RETN,RNASE4,ROCK1,RPS2,RUNX1,RUNX2,S100A10,S100A4,SDC1,SEC14L2,SELE,SELENBP1,SELENOP,SERPINE1,SIRPA,SLC16A7,SLC2A1,SLC38A2,SNAI1,SNAI2,SOAT1,SOCS3,SPP1,SREBF1,ST6GAL1,STAR,TAGLN,TCOF1,TGFB1,THBD,THBS1,TIMP1,TLR2,TLR4,TNFAIP6,TNFRSF10A,TNFRSF11B,TNNI1,TOP2A,TRPC6,TWIST1,VCAM1,VCAN,VEGFC,VIM,WNT4,ZFP36L1,ZFP36L2 | 1443 (15) |
| NOSTRIN | -9.80e-01 | transcription regulator | Activated | 4.20e+00 | bias | 0.0e+00 | ADAM17,ANXA5,CASP3,CAV1,Ccl2,COL18A1,FGF1,FN1,ITGA5,ITGB3,KDR,KIT,MMP2,NPR1,SELE,SELP,TEK,THBS1 | 812 (12) |
| mir-802 | NA | microRNA | Activated | 4.19e+00 | NA | 0.0e+00 | ACTA2,ARHGAP24,ARHGEF10,ARHGEF3,ARRDC3,CDC42EP3,CDH11,CDH19,CDH3,CDH6,CFL2,CREB1,CXCL12,CXCR4,EPB41L1,EPHA4,ERMP1,F2R,FGF1,FGF2,FMO2,FYN,GNAI1,GNAI3,GNB4,GNG10,GNG11,GNG2,HECW2,HEG1,HRAS,ITGA8,ITGB3,LIPG,MBNL1,MGST1,MRAS,NOX4,OAZ2,PDGFC,PDGFD,PIK3CG,PIK3R3,PKD2,PRDM16,RDX,RHOA,ROCK1,SDC2,SDC4,SMOC1,SMTNL2,SPP1,TESC,TMEM45A,VAV3,VEGFC,VIM,WIPF1,WNK2,ZDHHC2 | 1210 (12) |
| LAMA4 | -7.30e-01 | enzyme | Activated | 4.17e+00 | NA | 0.0e+00 | ACVR1B,ACVRL1,ANGPT2,ANPEP,CAV1,CAV2,Ccl7,CCND1,CCND2,COL3A1,COL4A6,COL5A1,COL5A2,COL6A3,CXCL12,CXCL16,CXCR5,FN1,GGCT,GGT5,GPX7,GSR,HGF,HIF1A,IDH1,IGF1,IL1R1,ITGA4,ITGA8,ITGB3,JAG1,KITLG,LAMA2,MET,MGST1,MGST2,PDGFC,PDGFRA,PIK3CG,SIPA1,SPP1,THBS1,THBS2,TNFRSF1B,VEGFC,VEGFD | 927 (7) |
| pyrrolidine dithiocarbamate | NA | chemical reagent | Activated | 4.17e+00 | NA | 0.0e+00 | ABCA1,AMIGO2,ANXA1,BCL2A1,BCL2L1,BIRC3,Ccl2,CCR5,COL1A1,CX3CL1,CXCL10,CXCR4,FAM3B,GBP2,GCLC,GDF11,GZMB,HIF1A,HLA-DRA,ICAM1,IGF1,IRF1,MMP14,MMP2,NFKBIA,NOX1,NR4A1,PDGFRA,PGK1,PLD1,PPARG,PTGS2,SAMSN1,SELE,SELP,SERPINE1,SLC2A1,TLR2,TLR4,VCAM1 | 904 (12) |
| miR-29b-3p (and other miRNAs w/seed AGCACCA) | NA | mature microRNA | Activated | 4.07e+00 | bias | 0.0e+00 | ADAMTS15,ADAMTS2,AXIN2,BCL2L11,CAV2,CCND1,CD276,CDH1,CDH2,CDK6,COL1A1,COL3A1,COL5A1,COL5A2,COL8A1,FBN1,GAS7,HDAC4,HMGN3,ID2,KLF4,LOXL2,LOXL4,NAV3,NID1,PDGFB,PIK3R1,PLOD2,PMP22,PPIC,PTP4A3,SHROOM2,SPARC,Tpm1,VCAN,ZFP36L1 | 1161 (17) |
| PSMB11 | NA | peptidase | Activated | 4.04e+00 | NA | 0.0e+00 | Abi3bp,Actn3,CAV1,Ccl2,Ccl7,CCND1,CD28,CLDN3,CNTN2,COL1A1,COL27A1,COL3A1,COL4A6,COL5A1,CREB5,CTSS,CXCL12,ENPEP,GADD45A,GADD45B,GFAP,GNB3,HPSE,HSPA1A/HSPA1B,IL18R1,IL2RG,ITGB7,KIT,L1CAM,LY75,NCAM1,NCF1,NID1,NR4A1,NR4A2,NTN4,OCLN,OLFML2B,PIK3CG,Pmaip1,PRKCB,PRKCZ,PTGS2,PTPRC,ROBO2,THBS1,THBS3,TNFRSF1B,TNFRSF8,VCAN,VEGFC | 1098 (7) |
| 3,5-dihydroxyphenylglycine | NA | chemical reagent | Activated | 4.00e+00 | NA | 3.0e-02 | ALDH1A1,BCAS1,CACNA1B,CACNA1D,CHCHD4,CPNE7,EGR1,FKBP9,INHBA,KIAA1549L,L1CAM,RPL14,RPL17,RPL18,RPL22,RPL23,RPL28,RPL35,RPL37A,RPL6,RPS10,RPS11,RPS15,RPS15A,RPS16,RPS18,RPS2,RPS24,RPS3,SMIM10L1,SYT17,TENM2,ZDHHC2 | NA |
| STAG2 | -5.30e-01 | other | Activated | 4.00e+00 | NA | 0.0e+00 | CCRL2,CXCL10,DHX58,GBP2,HERC6,IFI44,IFI44L,IFIH1,ISG15,OASL,PARP14,PARP9,RSAD2,SP110,UBE2L6,USP18 | NA |
| propylthiouracil | NA | chemical drug | Activated | 3.99e+00 | NA | 0.0e+00 | ABCC3,ALDH1A3,APBA2,AQP4,ART3,BCL11A,BCL11B,BDNF,BMP1,BTG2,C1QTNF3,CARHSP1,CDH1,CELSR3,CHKA,CNTN2,CORO1A,CRYM,CSRP3,DIO1,DLK1,EMB,EMP1,EMP3,ENPEP,EPHA3,FADS1,FADS2,FBLIM1,G6PD,GAP43,GAS2,GBP4,GLUL,HCAR2,IGF1,ITGA6,ITM2A,KIF5C,KLC1,LGALS1,LRRC4,MAN2A1,MAP2,MOXD1,MPP3,MRC1,MYH6,MYH7,MYOCD,NNMT,NR4A1,NRP1,NSMF,NTRK2,OXCT1,PCOLCE2,Pcsk1,PHLDA1,PRDM16,PROM1,QPCT,RAB3D,RHBG,RUSC2,SALL4,SERTAD4,SFRP2,SLC2A5,ST6GAL1,SYP,TMEM176B,TNNC1,TNNC2,TNNT1,TPO,TRHDE,TTYH1,TUBA8 | NA |
| APOE | -3.50e-01 | transporter | Activated | 3.96e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACADL,ACSL1,ACTA2,ADAM10,ADAMTS5,ADGRE1,ADIPOQ,ALOX12,Aox3,APOD,ATF3,BDH1,BGN,BMP4,C2,C3AR1,C5AR1,CASP1,CASP3,CAV1,Ccl2,CCND1,CCND2,CCR5,Cd209f,CD36,CD44,CD86,CLEC4M,COL18A1,COL1A1,CREB3L1,CSF1,CSF2RA,CSF2RB,CSRP1,CTSK,CTSS,CYBB,CYSLTR1,DAPK3,ECM1,EDN1,EGR1,ENG,F2R,F2RL1,F3,FCGR1A,FCGR2B,FKBP5,GAS7,GLUL,GPX3,GRIA2,HERPUD1,HSPA1A/HSPA1B,ICAM1,IGF1,IGFBP6,IL10RA,IL10RB,IL17A,IL1RN,IRF4,ITGA3,ITGA5,JAK3,KLF4,LIMS2,LIPG,LPL,LTBP1,LTBP2,MADD,MAP2,MAPK14,MMP2,MSR1,MYLIP,MYOCD,NCF1,NCF2,NMNAT2,NOX4,PC,PEA15,PHLDA1,PLIN1,PLPP3,PMEPA1,PPARD,PPARG,PPARGC1B,PRKCB,PRKCQ,PTGES,PTGS2,PTP4A3,PTX3,RELN,RTN4R,RXRG,SCTR,SDC4,SELE,SEMA6B,SERPINE1,SLC16A1,SLC25A44,SOCS3,SPP1,STAT1,STAT6,SYP,TGFB1,THY1,TIFA,TIMP1,TLR2,VCAM1,VCAN,VCP,WNT2 | 1261 (18) |
| N-[N-(3,5-difluorophenacetyl-L-Ala)]-S-phenylglycine t-butyl ester | NA | chemical - protease inhibitor | Activated | 3.81e+00 | NA | 0.0e+00 | ACKR3,ACTA2,BCL2L1,Ccl2,CHAC1,CLIP2,CNMD,COL27A1,COL2A1,CSF1,CXCL12,CXCR4,EPHB2,FAM20C,GADD45B,HEY2,ICAM1,IER3,INHBA,ITGA5,JAG1,KDR,KIT,LOX,MAOB,MIA,NOTCH2,PDGFB,POFUT1,PTPRF,REL,RFNG,RND3,S100A4,SEMA3F,SERPINE1,SGK1,SKP2,SNAI1,TBX3,TFPI2,TGFB1,TGFBI,TLR4 | 1485 (18) |
| USP8 | 5.00e-02 | peptidase | Activated | 3.81e+00 | NA | 7.0e-02 | B2M,CASP1,Ccl2,Ccl7,CXCL10,ERAP1,ERBB3,HLA-A,IFI16,IFIT1,IFITM3,ISG15,MET,OAS3,OASL,Oasl2,STAT1 | NA |
| PF543 | NA | chemical drug | Activated | 3.77e+00 | bias | 0.0e+00 | ACTA2,ATP6V0A4,CCR5,CLEC4M,CNN1,COL16A1,E2F2,FGR,FN1,GADD45GIP1,ITGB3,LOX,MYH7,ROCK1,SUSD5,TGFB1,TNC,TNFRSF11B | 1176 (15) |
| DKK1 | NA | growth factor | Activated | 3.77e+00 | NA | 0.0e+00 | ACTA2,ANGPT2,AXIN2,BDNF,BMP4,CCND1,CD44,CDKN1A,COL1A1,EPHB2,F2RL1,FGF2,LBH,LEF1,MITF,MYF5,MYH2,MYH6,MYH7,PPARG,PTGS2,RUNX2,SNAI2,SPARC,TAGLN,TBX3,Tcf7,TNNC1,TNNT2,TTYH1,TWIST1,WNT10B,WNT11,WNT5A | 1413 (21) |
| SB-431542 | NA | chemical reagent | Activated | 3.76e+00 | NA | 0.0e+00 | ACTA2,ADAMTS5,BGN,BMP4,C5AR1,Ccl2,Ccl7,CCND1,CD44,CDH1,CLIC4,COL1A1,COL3A1,CXCL13,DHCR7,FAP,FBN1,FN1,FOLR2,FOXP3,GADD45B,GFAP,GJB2,GPD1,ID2,IGF1,IGFBP7,ITGA11,LOX,MMP2,MRC2,MVD,PCOLCE,PITX2,PTX3,RHOA,RUNX2,SCN7A,SERPINE1,SMAD6,SMAD7,SNAI2,SPP1,STAR,TGFB1,TIMP1,TNFAIP6,VIM,XYLT1 | 960 (17) |
| PRKAA2 | 6.40e-01 | kinase | Activated | 3.74e+00 | NA | 0.0e+00 | ACOT7,ACTA1,ACTA2,ARHGDIB,CAMKK1,CDH1,CDKN1A,COX4I1,CXCL12,CYBB,DDAH1,EGR1,EIF2AK3,FN1,FOXO3,Gsta4,ICAM1,IFI44,Ifi47,IGFBP4,IL1R1,KCNA2,KCNQ2,KLHL29,MGST1,NCF1,NCF2,NFKBIA,NOS1,NOX4,NPEPL1,PCOLCE,PDGFRA,PPARG,PPP1R3B,PRDM16,RTN4RL1,SLC16A1,SNAI1,SOCS3,SPRED1,SPRED2,SREBF1,TTYH1,VCAM1,VIM,ZDHHC9,ZFP36L1 | 1428 (21) |
| miR-141-3p (and other miRNAs w/seed AACACUG) | NA | mature microRNA | Activated | 3.72e+00 | bias | 0.0e+00 | BAP1,BCL2L11,CACNA1G,CDH1,CDH2,CDK6,CYP1B1,DACH1,GADD45A,IRF6,JAG1,KCNK1,LEF1,LSR,MAP2K4,MMP2,MSLN,PITX2,PTPRD,RHPN2,RNF128,SNAI1,STAT5B,TBX5,VIM,WDR37,WIPF1,ZEB2,ZFPM2 | 1222 (14) |
| let-7a-5p (and other miRNAs w/seed GAGGUAG) | NA | mature microRNA | Activated | 3.66e+00 | bias | 0.0e+00 | AARSD1,ACTA2,ADAMTS15,ADAMTS2,ADAMTS8,ATP6V1F,BCL2L1,BDNF,Calm1 (includes others),CARHSP1,CASP1,CASP3,CCND1,CCND2,CDH2,CDK6,CHMP2A,COL1A1,COL27A1,COL3A1,COL5A1,COL5A2,COL8A1,CSDE1,CSNK1D,DAD1,DOCK5,DUSP23,EDN1,FADS2,FN1,HBA1/HBA2,ITGA1,ITGA4,ITGB3,KRT19,LOXL2,LOXL4,MLLT1,NID1,NXN,PDGFB,PGRMC1,PLOD2,PRDM1,PTGS2,PXDN,RASSF2,RBM19,RDH10,RPP38,S100A4,SCYL1,SLC1A4,SLC25A24,SLC38A1,SMOX,SPARC,SPCS3,TAGLN,THBS1,TLR4,Tpm1,TYMS,UGT8,UHRF1,VCAN,VIM | 1345 (18) |
| 2-amino-5-phosphonovaleric acid | NA | chemical - other | Activated | 3.64e+00 | NA | 0.0e+00 | ADAM19,ADAMTS1,ADAMTS2,ARID5A,BDNF,BTG3,CAMKK1,CDK20,CGN,CX3CL1,DACT2,DUSP1,DUSP6,EGR1,EGR2,EGR3,ELP6,EXT1,FBXO33,FOXO1,GADD45A,GADD45B,GADD45G,GFRA1,GOLM1,GTF3C5,HDAC4,HDAC9,KCNK6,KDR,LBH,LHFPL2,NHSL1,NR4A1,NR4A2,NR4A3,NUDT4,OLFM1,PHLDA1,PLEKHO1,PLK3,Pmaip1,PRKAB2,PTGS2,RASGEF1B,RGS2,RPS15A,RUNX1T1,SLC25A38,SPRY4,TIMM29,TMEM200A,TSPAN18,Zfp60,ZNF605 | 965 (20) |
| PNPT1 | -6.80e-01 | enzyme | Activated | 3.63e+00 | NA | 0.0e+00 | BCL2L1,CDKN1A,CXCL10,GBP2,GBP4,IFI16,IFI44,IFIH1,ISG15,Oasl2,PARP14,PARP9,RNF213,RTP4,Sp100,STAT1,TOR3A,UBE2L6,USP18 | 1254 (14) |
| IKZF3 | 2.30e-01 | transcription regulator | Activated | 3.58e+00 | NA | 0.0e+00 | ALOX5,ANTXR1,BCL2L1,CAV1,CAV2,CITED2,FN1,HHATL,IGSF11,KLF4,LHFPL2,MAN1C1,MAP2,OTUD1,PROS1,RASSF4,RNF213,RTP4,RYR1,SEMA5A,TLR4 | NA |
| MLXIPL | 2.10e-01 | transcription regulator | Activated | 3.57e+00 | bias | 1.0e-02 | ADGRE1,ANXA2,Ccl2,GPAM,GPAT3,GPD1,HIF1A,KHK,MRC1,PLIN1,PNPLA2,PNPLA3,PPARG,PYGL,RPL14,RPL17,RPL18,RPL22,RPL23,RPL28,RPL35,RPL37A,RPL6,RPL7L1,RPS10,RPS11,RPS15,RPS15A,RPS16,RPS18,RPS2,RPS24,RPS3,SREBF1,TKT,UCP3 | NA |
| FOXO4 | 3.60e-01 | transcription regulator | Activated | 3.57e+00 | NA | 0.0e+00 | APLN,BCL2L1,BCL2L11,BCL6,CASP8,CAV1,CCND1,CCND2,CDC42EP3,CDKN1A,CERS4,EDNRB,ELOVL5,ELOVL7,ENPEP,FMOD,FOXC1,FYN,GABARAPL1,GADD45A,GADD45B,GPX3,HIF1A,IER3,IGFBP7,IL10RB,IL1R1,ITGB2,JAG1,LCP2,LRAT,MAFA,MAP1LC3B,NRP2,PDIA4,PLA2G2D,PRCP,PRKAA2,PRKCD,PTPRB,PTPRC,RUNX2,Scd2,SERPINE1,SESN1,SGK1,SLC2A1,TGFB1,VCAM1 | 1497 (21) |
| thioctic acid | NA | chemical drug | Activated | 3.55e+00 | NA | 1.9e-01 | ANGPT2,Ccl2,ICAM1,LPL,MITF,MMP2,NFE2L2,PARK7,PDK4,PPARD,SELE,TRPV1,VCAM1 | NA |
| actinomycin D | NA | biologic drug | Activated | 3.53e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ATP1A1,BCL2A1,BCL2L11,BDNF,BIRC3,CASP1,CASP3,CAV1,CCND1,CD28,CDH2,CDKN1A,CERS6,CLEC11A,COL2A1,DDIT4,DUSP1,ERRFI1,ETS1,F3,FADD,FEN1,FGFR1,FLNA,FN1,GADD45A,GAPDH,GCH1,GDA,GPI,HIF1A,HK1,HOMER1,ID2,IGFBP4,IGFBP5,IRF1,IRS1,IRS2,LPL,LTB4R,MADD,MMP2,Mt1,NTRK2,PFKFB3,PLA2G2A,PPARG,PTGIS,PTGS2,PTX3,RETN,RGS2,RGS4,RIPK2,SCNN1G,SELE,SERPINE1,SFRP1,SLC12A4,SLC20A1,SLC27A1,SLC2A1,SMAD7,SOCS3,SPHK1,SPP1,TGFA,TGFB1,TLR2,TNFAIP2,TNFRSF10A,TNFRSF1B,TP53BP2,VEGFC | 1566 (18) |
| STK11 | 5.40e-01 | kinase | Activated | 3.51e+00 | NA | 0.0e+00 | A2M,ACVR1,ALCAM,ALDH9A1,ALDOA,ATF3,ATP6V1F,BCL2L11,BCL6B,BMP5,CAMKK1,Ccl2,CCNA2,CCND1,CDH1,CDKL3,CDKN1A,COL3A1,COX6B1,CSF3R,DCTPP1,ECM2,FN1,GADD45A,GADD45B,GAPDH,GLI1,GPI,HDAC4,HIF1A,IGFBP5,IL17A,IL2RB,IL33,KCNA2,KCNQ2,KLHL29,LGALS9B,LUM,MED26,MMP2,MPST,MRI1,NDUFB9,NDUFC2,NDUFS7,NDUFV1,NEDD9,NET1,NPEPL1,NR4A1,NR4A2,NRCAM,PDGFRL,PGK1,PGM1,PHGDH,PKM,POLA2,POLR2E,POLR2F,PPARG,PSMB5,PTGS2,PTPN3,PTPRZ1,RASGRP1,RASSF2,SERPINE1,SMO,SNAI1,SNAI2,SPP1,STARD10,TGFA,TKT,TNFRSF4,TOP2A,TTYH1,TWF2,TYMS,UMPS,UQCR10,UQCR11,USP19,VAV3,VIPR2,WNT2,WNT5A | 1468 (19) |
| immethridine | NA | chemical reagent | Activated | 3.50e+00 | bias | 0.0e+00 | BTK,C3,C5AR1,Ccl2,Ccl7,CCR5,CD44,CFI,CNR1,CTSS,FCGR1A,IFI16,OLR1,SOCS3,SPP1,VCAM1 | 386 (7) |
| miR-146a-5p (and other miRNAs w/seed GAGAACU) | NA | mature microRNA | Activated | 3.49e+00 | bias | 1.0e-02 | Ccl2,CCNA2,CCR3,CD1D,CFH,COL13A1,CRP,CXCR4,DMBT1,FADD,IL1R1,IL1RL2,IRAK2,IRF5,LBP,METTL7A,MR1,NFKBIA,NOVA1,PDGFRA,PLEKHA4,PTAFR,STAT1,TLR10,TLR4,UHRF1,VWCE | 1143 (15) |
| mir-142 | NA | microRNA | Activated | 3.48e+00 | NA | 0.0e+00 | AFAP1,AHR,CD93,CFL2,GBP2,GBP4,GBP5,GBP7,HIF1A,HLA-A,IL1RL1,IL2RA,IL2RB,INPP4B,IRF1,ITGA1,ITGAD,KIT,NRP1,PROM1,SOCS1,SOCS3,STAT1 | 773 (11) |
| PPARGC1A | 3.30e-01 | transcription regulator | Activated | 3.48e+00 | NA | 0.0e+00 | A2M,ACADL,ACO2,ADAMTS1,ADAMTS2,ADAMTS5,ADIPOQ,AK1,APOD,ATP2B3,BCAT2,BDH1,BMP4,C2,C3,CASP8,Ccl2,Ccl7,CD36,CDKN1A,CEBPD,COL2A1,COL6A3,COX4I1,CPLX1,CTSC,CXCL10,CXCL14,DCN,DIO1,EBF2,EDN1,EGFL6,EGLN1,ELMO1,EMILIN2,Esrra,FBLN1,FBXO32,FIBIN,FNDC5,GADD45B,GDF11,GFRA1,GPAM,HIF1A,ICAM1,IDH3A,IGF1,IGFBP5,IGFBP6,IGFBP7,IL1RN,INHA,INHBA,INHBB,INPP5J,IRS1,IRS2,ITGB4,KCNK1,LAMA2,LAMA4,LDHB,LGALS9B,LPIN1,LPL,LUM,MAL,MAOB,MAPK14,MB,MFAP5,MITF,MMP15,MMP19,MMP2,MSI1,MSMO1,MYBPC3,MYH6,MYH7,MYL2,NCEH1,NDUFV1,NDUFV2,NFKBIA,NR4A1,NR5A1,NR5A2,OGN,OLFML3,OLR1,OSMR,OXCT1,PCSK5,PDGFRL,PDIA5,PDK2,PDK4,PDPN,PIK3R1,PLA2G7,PNPLA2,PPARG,PPARGC1B,PRDX5,PRKAA2,PTGS2,PTN,PVALB,RUNX2,RXRA,SEMA3A,SEMA3C,SERPINH1,SLC25A25,SLIT3,SMAD7,SMYD1,SOCS1,SOCS3,SREBF1,STAR,STAT1,STAT5B,SVEP1,THY1,TIMP1,TNFRSF11B,TNNC1,TNNI1,TRADD,TRIM63,UCP3,VCAM1,VCAN,VEGFD,WDR77 | 1590 (24) |
| SETD2 | 1.20e-01 | enzyme | Activated | 3.45e+00 | NA | 0.0e+00 | AXIN2,BTRC,CAV1,CCND1,CDH2,CITED2,CSNK1D,ENG,FOXO3,GNA13,HHEX,IGF1,LAMA4,PDGFC,PRRX2,SEMA3C,SERPINE1,SERPINF1,WNT5A | 1269 (12) |
| JQ1 | NA | chemical reagent | Activated | 3.44e+00 | NA | 0.0e+00 | ADORA2A,AMPD3,BCL2L1,BCL2L11,BIRC3,BTK,Ccl2,CCNA2,CCND1,Cd33,CDK6,CISH,CXCR4,DHCR7,FOXO3,FOXP3,GADD45G,IFIT1,IL17A,IL2RA,IRAK3,IRF4,ISG15,KDM3A,KIF23,MAP1LC3B,MKI67,MVD,MX1,MYCN,NFKBIA,NMNAT1,NRP1,Oasl2,PRDM1,SH2D4A,SIGIRR,SOCS3,SPP1,STRA6,TCOF1,TICAM2,TLR2,TLR4,Tnfrsf26,TOP2A,TP63,TUBB | 1088 (14) |
| mir-29 | NA | microRNA | Activated | 3.43e+00 | NA | 0.0e+00 | ACTA2,ADAMTS9,AOX1,BDKRB2,CALCR,CCND1,CD276,CDH1,CDH2,CDK6,CLDN1,COL1A1,COL3A1,COL5A2,COL7A1,CTSK,ELN,FKBP5,FN1,IGF1,IL2RA,ITGA11,KIT,KLF4,LPL,MMP2,MYCN,NAV3,NID1,OLR1,PDGFC,PDGFRA,PIK3R1,PMP22,RUNX2,SFRP2,SPARC,THBS1,Tpm1,VIM,ZFP36L1 | 1299 (18) |
| U0126 | NA | chemical drug | Activated | 3.42e+00 | NA | 0.0e+00 | ACKR3,ACTA2,ADGRE1,ADIPOQ,ANGPT2,APLNR,ARHGEF2,ASGR2,ASIC2,ATF3,ATP6AP2,AXIN2,BCL2L1,BCL2L11,BDNF,BHLHE40,BIRC3,BRAP,C3,CA9,CACNB3,CAV1,Ccl2,CCND1,CCND2,CCNE2,CD200,CD36,CD44,CDC42EP3,CDH1,CDK18,CDK2,CDK5R1,CDKN1A,CEBPD,CIITA,COL1A1,COL2A1,CSF1R,CXCL10,CXCL12,CXCR4,CYBB,CYP1B1,CYP4F2,DAB2,DBP,DCHS1,DDAH1,DMP1,DNASE1L3,DUSP1,DUSP10,DUSP5,DUSP6,EDN1,EDNRB,EEF1A1,EEF1E1,EGF,EGR1,EGR3,EIF2AK3,EIF4EBP1,ELN,EMP1,ERCC1,ERRFI1,ETS1,ETV1,ETV5,F3,FGF2,FKBP5,FLT3LG,FN1,G0S2,GADD45B,GAMT,GCLC,GFAP,GFPT2,GLI1,GPR34,GRAMD1B,GRIA2,Gsta4,HERPUD1,HIF1A,HLA-DQA1,ICAM1,IER3,INHBA,IRF1,ITGA2B,ITGA3,ITGA5,ITGA6,JAG1,JUND,KDR,KLF10,KLF5,LAMP2,LPL,MAPK3,MAT2A,MET,MICU1,MMP2,MRPL21,MRPL22,MRPS12,MRPS9,MYH7,MYO7A,MYOG,NAV3,NDUFA1,NDUFAB1,NDUFC1,NFE2L2,NOS1,NOX1,NR4A1,NR4A2,NR4A3,NR5A1,OCLN,OSMR,PAWR,PER1,PHLDA1,PLA2G4A,PLAGL1,PLD1,PLIN1,PLK2,PNMT,PPARD,PPARG,PRELP,PRKCB,PTGS2,PTPN12,PTPRJ,RAC2,RETN,RND3,ROCK1,RUNX1,RUNX2,RXRG,SCN1B,SELP,SERPINE1,SGK1,SIRPA,SIRT2,SIX4,SLC2A1,SNAI2,SOCS1,SOCS3,SPNS2,SPP1,SREBF1,STAR,STAT1,SYK,SYP,Tcf7,TFPI2,TGFA,THBD,THBS1,TLR2,TNFRSF11B,TOP3B,TRIB1,TSC22D4,TWIST1,UBC,VCAM1,VIM,ZFP36 | 1404 (15) |
| mir-8 | NA | microRNA | Activated | 3.38e+00 | NA | 0.0e+00 | ACTA2,ADAMTS1,ATF3,CCND1,CCND2,CCNE2,CD47,CDC25B,CDH1,CDH2,CDK6,CDKN1A,CFL2,CITED2,CLDN1,CLDN3,DDIT4L,ERRFI1,ESM1,ETS1,EZH2,FN1,GATA4,GNA13,HDAC4,HIF1A,HOXA5,JAZF1,KCNK1,KDR,KITLG,KLF4,KRT19,LEPR,LOX,LSR,MET,MSLN,MSN,MYH10,MYOF,OCLN,Pmaip1,PROM1,RHPN2,RNF128,RPS6KB1,SEC23A,SKP2,SNAI1,SNAI2,SULF2,TSPAN1,VIM,WIPF1,ZEB2,ZFP36,ZFPM2 | 1382 (23) |
| TSC2 | 1.70e-01 | other | Activated | 3.36e+00 | NA | 0.0e+00 | A2M,ANXA1,ANXA2,ATF3,ATP6AP2,ATP6V0B,ATP6V1A,AXIN2,B3GALT2,BCL3,CACNA1D,CASP1,Ccl2,CCND1,CCND2,CDKN1A,CP,CRYAB,CTSK,CXCL10,CXCL12,EGLN1,EGR1,EGR2,EMP3,FAM107A,GAP43,GFAP,GPNMB,HIF1A,IFI44,Ifi47,IFITM3,IGFBP5,IL1R1,IRS1,IRS2,LDHB,LGR5,LOC728392,LPAR1,MAOB,Mt1,NEU1,NKD1,PDGFRA,PDK4,PGM2L1,PKIB,PPP1R3B,PRELP,PSMB1,PSMB5,PVALB,RASSF4,RTN4RL1,S100A11,S100A6,SLC2A1,SOCS3,SPRED1,SPRED2,STAT1,TAGLN,TMEM176A,TMEM176B,ZFP36 | 1177 (20) |
| nitrofen | NA | chemical toxicant | Activated | 3.36e+00 | bias | 0.0e+00 | APLNR,AQP4,CACNA1D,CLCN7,CLIC4,EGR1,FGFR1,HK1,ITGA6,KCNJ15,RARA,S1PR2,SCN3B,SCNN1G,TGFB1I1 | NA |
| IL1RN | -1.61e+00 | cytokine | Activated | 3.36e+00 | NA | 0.0e+00 | ACTA2,ATF3,BTRC,CD44,CDKN1A,CHAC1,CIITA,CTSS,EIF2AK3,H6PD,HDAC9,HERC6,ICAM1,IFI44,IFI44L,IFIH1,IGF1,IGFBP4,IGFBP5,IL17A,IL18BP,IRF1,KLF6,L1CAM,MX1,NR0B2,OAS3,OASL,PTGS2,RARRES1,RIPK2,RSAD2,RTP4,SELE,SERPINE1,SLC15A3,SPP1,STAR,THEMIS2,TIMP1,USP18,VEGFC,ZNF81 | 1133 (15) |
| RC3H2 | -3.00e-01 | enzyme | Activated | 3.32e+00 | NA | 0.0e+00 | ANPEP,EDN1,EGF,ENG,EPHB4,FGF1,FGF2,HIF1A,HPSE,IL17A,ITGAE,MMP2,NRP1,PDGFC,SDC1,TGFB1,TNFRSF4,VEGFC | 919 (9) |
| GSR | -7.20e-01 | enzyme | Activated | 3.32e+00 | NA | 3.0e-02 | ABCC3,Abcg3,AOX1,BLVRB,CD36,GCLC,Gsta4,LPIN1,SLC2A1,TKT,UGDH | NA |
| ML290 | NA | chemical reagent | Activated | 3.30e+00 | NA | 0.0e+00 | ACTA2,CAV1,COL1A1,COL3A1,COL5A1,COL6A3,INHBB,IRAK2,PDGFRA,RXFP1,TGFB1 | NA |
| aprepitant | NA | chemical drug | Activated | 3.30e+00 | bias | 0.0e+00 | ANXA1,C3,ECM1,EGR1,FLRT3,INHBA,ITGA6,L1CAM,MMP14,PTAFR,SEMA7A,SPARC,SULF2,TNC,TP63,TSPAN2,UNC13D,VTCN1 | NA |
| COL18A1 | -6.70e-01 | other | Activated | 3.30e+00 | NA | 0.0e+00 | ANTXR1,BCL2L1,CCND1,CD34,CDC25B,CDKN2C,DDIT4,EDN1,EDNRB,EGLN1,EPHB2,EPHB4,ETS1,F2R,F2RL1,F3,FGF2,FGFR1,FN1,GFAP,HGF,HIF1A,HIF1AN,ICAM1,ITGB2,ITGB3,KDR,MAX,MMP2,NRP1,PTGS2,SELP,SERPINE1,STAT1,THBS1,TUBA1A,VWF | 919 (17) |
| ZNF217 | 2.60e-01 | transcription regulator | Activated | 3.27e+00 | NA | 0.0e+00 | ATP10D,CCNE2,CENPK,COL8A1,CREB5,CXXC4,DPP6,ERBB3,FRK,GAD1,GATA4,IFI16,ITM2A,KCNK2,KLHL4,MPZL2,MYCN,NEFL,NMNAT2,NRK,PLAT,RGS20,SEC14L2,SEMA3A,SH3RF2,SHC4,ST3GAL6,ST6GAL1,STRA6,VSNL1,ZNF367 | NA |
| miR-30c-5p (and other miRNAs w/seed GUAAACA) | NA | mature microRNA | Activated | 3.27e+00 | bias | 0.0e+00 | ACVR1,ADAMTS15,ADAMTS2,ADRA2A,ANPEP,ATP2A2,ATRX,BCL6,BDNF,CBFB,CCND1,COL1A1,COL5A1,COL5A2,COL8A1,GALNT7,GPD2,IDH1,IRS2,ITGA2,LMNB2,LOXL2,LOXL4,MAFA,MAT2A,MBNL1,MET,MLLT1,MYH7,MYO10,NCEH1,NID1,NPR3,NUCB1,PCDH17,PDGFB,PGM1,PLOD2,PPARG,PPP3CA,PTGFRN,PTPA,RUNX2,SEC23A,SLC12A4,SLC38A1,SLC38A2,SLC4A10,SLC7A1,SPARC,TMED3,TNFAIP2,TP63,Tpm1,UAP1,VCAN,WNT5A | 1100 (7) |
| SOX1 | NA | transcription regulator | Activated | 3.27e+00 | bias | 0.0e+00 | ACVR1,APCDD1,CHST15,COBLL1,CRYGA,DUSP1,DUSP5,ECSIT,FABP1,FARP1,FRZB,GBP4,IER5,INHBA,IRS1,NRP1,Oasl2,PCDH18,PDGFRA,PITX2,TNFRSF19,TWIST2,USP18,WLS,WNT5A | NA |
| ALDH1A2 | -2.60e-01 | enzyme | Activated | 3.27e+00 | NA | 0.0e+00 | ALDH1A1,ALDH1A3,ATF3,BGN,CD44,COL3A1,CSF1,FGF2,HOXD4,IGFBP4,KIT,PCOLCE,SPARC,SPP1,TGFBI,TIMP1 | 1236 (11) |
| USP19 | 9.00e-01 | peptidase | Activated | 3.26e+00 | NA | 0.0e+00 | BIRC3,Ccl2,CXCL10,DDIT4,FBXO32,FKBP5,FOXO3,KLF15,MYOG,PFKFB3,TRIM63 | 1122 (18) |
| epigallocatechin-gallate | NA | chemical drug | Activated | 3.25e+00 | NA | 0.0e+00 | ACP5,ADAM10,ADORA2A,AHR,ANGPT2,AQP4,AXL,BCL2L1,CACNB3,CALCR,CASP1,CASP3,CASP8,Ccl7,CCND1,CDH1,CDKN1A,COL18A1,CSF2RA,CTSK,CXCL10,EDN1,EGR1,ELF1,F3,FADD,FN1,FOXO3,FOXP3,GADD45A,GADD45B,GBP4,GCLC,GJB2,GLI1,GSR,HIF1A,ICAM1,Ifi47,IL17A,IL1R1,IRF1,ISG15,ITGB3,JAK3,JUND,KDR,MKI67,MMP2,NFE2L2,NFKBIA,NOS1,NOTCH2,NR4A2,OCLN,PDIA4,PRKCE,PTGS2,PTN,REL,SERPINE1,SFRP1,SLC16A1,SNAI1,SNAI2,SOCS1,STAT1,SYT3,TGFB1,TIMP1,TLR4,TNFRSF10A,VCAM1,VEGFC,VIM | 1181 (13) |
| mir-21 | NA | microRNA | Activated | 3.25e+00 | NA | 0.0e+00 | ACTA2,AIF1,ALOX15,AOAH,ARL6IP1,BTG2,C1R,C8orf44-SGK3/SGK3,CAMKK1,CARD6,Casp12,Ccl2,CCNA2,CD180,CD226,CD44,CD86,CDH1,CDK6,CDKN1A,COL1A1,COL3A1,CSF3R,CXCL10,DBP,DDAH1,DDAH2,DHX58,ECT2,EGR2,EIF4E3,ELN,F830016B08Rik,FAM217B,FCGR1A,FCGRT,FGF1,FGL2,FLT3LG,FN1,FOXP3,FUBP1,GBP2,GBP5,GBP7,GFAP,HOMER2,ICAM1,IFI16,Ifi47,IL17A,INPP5D,IPO11,IRF1,JAG1,KIF23,KIF4A,KNTC1,LAMP2,Ldha/RGD1562690,LEPR,MKI67,MMP2,NCAPG,NINJ1,Nlrp1a,NLRP3,NMT2,NPAS2,NTN4,OAS3,PDCL,PDE1C,PER3,PIP4K2A,PLAT,POLR2F,PPP1R3B,PRAG1,PRC1,PROSER2,PRRG4,PSMB5,RAB7B,RECK,RP2,SELENOP,SESN1,SIRPA,SLAMF1,Slfn2,SMAD7,SMC2,SOCS1,Sp100,SRSF3,STAT1,STMN1,TACC3,TGFB1,TLR2,TLR4,TOP2A,UBA7,UBE2L6,VCAM1 | 1182 (16) |
| Sb202190 | NA | chemical drug | Activated | 3.24e+00 | NA | 0.0e+00 | ACTA2,ALOX5,ASAH2,Ccl2,CCND1,CCND2,CD86,CDH2,CDKN1A,CKM,COL1A1,CRP,CXCL10,EGR1,FN1,HIF1A,ICAM1,IFIT1,MAP1LC3A,MMP2,MYOD1,MYOG,PHLDA1,PLA2G2A,PLA2G4A,PPARGC1B,PRDX1,PTGS2,RUNX1,RUNX2,SELE,SERPINE1,SGK1,SNAI1,SNAI2,SPP1,TNFRSF10A,TP63,VCAM1,VIM | 1417 (15) |
| SP110 | -9.00e-01 | transcription regulator | Activated | 3.24e+00 | NA | 0.0e+00 | ANXA5,ATF3,BCL2L12,BCL3,BMP4,CD74,CXCL10,DAB2IP,DUSP10,EEF2K,EGR3,ERCC1,ETS1,F2R,F3,GNA13,IFIH1,IFIT1,IFITM3,IL1R1,MX1,MYCN,NFIL3,OAS3,PANX1,PDGFC,PLK1,PPARG,PTAFR,PTPN12,RIPK2,RXRA,SMARCD3,STAT1,SUMO3,TAB3,TBX3,TIMP1 | NA |
| mir-181 | NA | microRNA | Activated | 3.24e+00 | NA | 0.0e+00 | BCL2L11,CASP3,CDKN1A,CREB1,DUSP6,E2F5,EZH2,GRIA2,ICAM1,IL17A,IRF8,KLF6,MME,MMP14,NOVA1,PBX3,PRKCD,PTGS2,RUNX2,SIX2,SLC47A1,SMAD7,VCAM1,ZEB2 | 1089 (16) |
| miR-92a-3p (and other miRNAs w/seed AUUGCAC) | NA | mature microRNA | Activated | 3.23e+00 | bias | 0.0e+00 | BCL2L11,CCNA2,CCND1,CCND2,CCNE2,CDK2,CDK6,CDKN1A,CDKN2C,EDNRB,ITGA5,ITGB3,KLF4,MAP2K4,MYLIP,NOX4,OSBPL2,TBX3,TP63,VSNL1,ZEB2 | 1061 (11) |
| miR-291a-3p (and other miRNAs w/seed AAGUGCU) | NA | mature microRNA | Activated | 3.21e+00 | bias | 2.0e-02 | ARHGEF3,C3,CASP1,CASP3,CCND1,CCND2,CD44,CD83,CDH1,CDKN1A,CENPF,CFL2,CNOT6,GLTP,GPSM2,HERPUD1,KIF23,MYBL1,NR4A2,PRC1,RECK,STX11,TMEM263,TP63,UBXN1 | NA |
| miR-450a-5p (and other miRNAs w/seed UUUGCGA) | NA | mature microRNA | Activated | 3.21e+00 | bias | 0.0e+00 | COL3A1,COL5A2,EMP3,HGF,ITGA5,JAG1,SERPINE1,SNAI2,SPP1,STEAP1,TGFB1,TMEM132A,TWIST1,VIM | NA |
| CLDN7 | -1.40e-01 | other | Activated | 3.19e+00 | NA | 1.0e-02 | ABLIM1,ARHGDIB,C3,CA12,CBX2,CCDC97,CKAP4,CX3CL1,F3,F5,FADS3,FZD2,H2AC18/H2AC19,IFI44,IGFBP7,LIMA1,MMP2,MX1,NCOA7,NNMT,NSA2,NTPCR,PHGDH,PRKCZ,SERP1,SLC25A22,SLCO2A1,SOSTDC1,SYTL2,TINAGL1,TPRG1L,UBE2L6 | 596 (7) |
| PGR | -1.50e-01 | ligand-dependent nuclear receptor | Activated | 3.18e+00 | NA | 0.0e+00 | A2M,ACP5,ACSL1,ADAM19,ADAMTS1,ADRA2A,AK4,ALDH1A3,ALOX15,AMD1,ARHGAP29,ATP1B1,BARD1,BCL2L1,BCL6,BGN,BIRC3,BMP1,BRCA2,BTG1,BUB1,CA12,CADM4,CCND1,CD36,CD44,CDH2,CDKN1A,CEBPD,CKAP4,COL12A1,COL14A1,COL1A1,COL4A6,COL5A1,COL5A2,COL6A3,COL7A1,COL8A2,CSGALNACT1,CSRP1,CTSK,DCHS1,DNAJB4,DPYSL2,DYNLL1,EDN1,EIF5B,ELL2,ELN,ENC1,EPS8L2,EZR,F2RL1,F3,FAM89B,FBN1,FGF2,FHL1,FKBP5,FLNA,FLRT2,FLRT3,FN1,FOXC1,FOXO1,GLUL,GPR160,HAS3,HBA1/HBA2,HDC,HIF1A,HSPA2,ICAM1,IER3,IFI16,IFI44,IFI44L,IFIT1,IGFBP5,IL1R1,IRS1,IRS2,ISG15,ITGA1,ITGA10,ITGA11,ITGA2,ITGA3,ITGA4,ITGA6,ITGA8,ITGB3,ITGB4,KCNH2,KCNK1,KIF18A,KIF24,KLF4,KLF5,KLF9,LAMA4,LCP1,LOX,LOXL1,LOXL2,MAT2A,MATK,MFAP5,MMP2,MPZ,MPZL2,MTSS1,MX1,MYCN,MYO10,NDRG4,NEDD9,NET1,NFKBIA,NOP16,NOTCH2,NRP1,NT5C2,NTN1,OAS3,OASL,OCEL1,PDGFB,PDLIM1,PDPN,PFKFB3,PGRMC1,PLK2,PNMT,PPARG,PPM1H,PRKG2,PTGES,PTGS2,PXDN,RASGRP2,RASSF2,RHOBTB1,RND3,RSAD2,RUNX1,S100A6,SBK2,SCUBE1,SCUBE3,SCX,SDC1,SDK2,SELENOP,SERPINB8,SERPINE1,SERPINH1,SGK1,SIK3,SLC39A8,SLC9A1,SMPDL3B,SNTB2,ST3GAL1,STAT1,STAT5B,STEAP1,STMN1,STMN4,TBC1D8,TENM2,TGFB1,TGFBI,TIPARP,TLL1,TM4SF1,TNC,TRAF5,UGCG,VCAM1,VCAN,VWF,WNT4 | 2073 (23) |
| triamcinolone acetonide | NA | chemical drug | Activated | 3.18e+00 | NA | 0.0e+00 | ACKR4,ACSL1,ADCY7,ATF3,ATP10A,AUH,BCL2A1,BCL2L11,BHLHE40,BMP4,BMP5,BTG2,CD22,CD44,CHKA,CHL1,COL13A1,CXADR,CYTIP,DUSP1,DUSP10,E2F2,EFS,EGR1,ELK3,EPHA4,FKBP5,FOXO3,HCK,IGFBP4,ITGA10,KCND1,KCNJ12,KIF4A,KLF10,KLF15,KLF9,MEGF9,NFATC3,NFKBIA,NOS1,NTM,PALLD,PDIA5,PER1,PER3,PEX13,PEX6,PKD2,PLK2,PTPN7,RGCC,RGS2,RUNX1,SFRP2,SLAMF1,SLC16A1,SOAT1,SPP1,ST8SIA4,TACC2,TNFAIP8,TRIB1,UGT8,VWF,ZBTB16,ZNF189 | 1280 (13) |
| dexamethasone phosphate | NA | chemical drug | Activated | 3.16e+00 | NA | 0.0e+00 | Arrdc2,BCL6,CXCR4,DDIT4,DUSP1,ERRFI1,GADD45G,GPD1,Mt1,NFKBIA,PDK4,PLEKHF1,SCN7A,SGK1,THBS1,TIPARP,TNFRSF11B | 902 (7) |
| ETV7 | NA | transcription regulator | Activated | 3.15e+00 | bias | 0.0e+00 | BTG1,CCL24,CD47,CFB,GCH1,HERC6,ICAM1,IFITM3,PARP14,RARA,UBE2L6 | NA |
| bisindolylmaleimide I | NA | chemical drug | Activated | 3.14e+00 | NA | 0.0e+00 | BCL2A1,BCL2L1,BIRC3,CCND2,CD44,CDKN1A,CLDN1,E2F2,EGR1,EIF4EBP1,FGF2,FN1,GAP43,GATA4,HAS2,ICAM1,IGF1,JUND,KCNC1,KCNJ11,LPL,MAPK3,MAT2A,MET,MMP2,Mt1,MYH6,MYH7,NFKBIA,NR4A1,NR4A2,NR5A1,OCLN,OXTR,PLD1,POU2F2,PRKCD,PRKCE,PTGS2,SAMSN1,SERPINE1,SNAI1,TNNT2 | 1141 (15) |
| CDKN1A | 2.54e+00 | kinase | Activated | 3.14e+00 | NA | 0.0e+00 | ACTA2,ADAM10,ARL6IP1,ATRX,BCL2L1,BUB1,BUB1B,CASP3,CCNA2,CCND1,CD44,CDC25B,CDH1,CDKN1A,CDS1,CENPF,CIT,CLIC4,COL5A1,CPA3,CRYAB,CTSK,CYP1B1,DSE,DUSP1,E2F2,E2F5,E2F7,ECSIT,EIF4EBP1,FGF2,FHL1,FN1,GADD45A,GNAI1,HIF1A,HSPA1A/HSPA1B,ICAM1,ID2,IFITM3,IL16,IL1R1,INHBA,IRF6,ITGA2,ITGA3,ITGB3,ITGB4,JAG1,KNTC1,LIMA1,LOXL2,MAF,MCM7,MET,MKI67,MSN,MYOD1,NFKBIA,NRP1,NRP2,OLFML2B,OSMR,PDGFC,PHGDH,PLEKHO1,PLK1,PLK2,Pmaip1,PRC1,PROM1,PTPRC,RBL1,SERPINE1,SMC2,SNAI2,SPARC,SSPN,STK3,STMN1,TGFA,THBS1,TNC,TNFAIP6,TOP2A,TP63,TSPAN1,TUBB4A,TYMS,UHRF1,VGLL4,VIM,WNT4,ZBTB5 | 1461 (18) |
| miR-16-5p (and other miRNAs w/seed AGCAGCA) | NA | mature microRNA | Activated | 3.12e+00 | bias | 0.0e+00 | ALDH1A3,ANAPC16,BDNF,CA12,CCND1,CCND2,CDC14A,CDC14B,CDK6,CFL2,DNAJB4,EGLN2,FGF2,FGFR1,GALNT7,GPAM,HACE1,HERC6,HSDL2,HSPA1A/HSPA1B,HYAL3,IGF1,ITGA2,KIF23,KITLG,LAMTOR5,LDAH,LUZP1,MAP2K4,MAPK3,MLLT1,MYH7,NIPAL2,NOTCH2,NPR3,NT5DC1,OGT,OMA1,PANX1,PCDH17,PHKB,PHLDB2,PLK1,PTGS2,RAB30,RAB9B,RECK,RIDA,SEC24A,SKAP2,SLC16A3,SLC25A22,SLC38A1,SLC7A1,TMEM43,UGDH,VTI1B,WEE1,WIPF1 | NA |
| MIR17HG | NA | other | Activated | 3.12e+00 | NA | 0.0e+00 | ACTA2,APCDD1,BCL2L11,BMP4,CCM2,CCND1,CDKN1A,CELSR1,CLIC1,COL5A1,CREB1,CXCR5,DAB2IP,DCHS1,DLL1,ECSIT,FBN2,FZD1,FZD2,FZD4,GDF11,GPC3,HDAC4,HEG1,HIF1A,HIF1AN,HK1,HOPX,HOXA5,HOXB5,JAG1,KIT,LTBP1,MAN2A1,MYCN,NCOR2,NOTCH2,PDGFRA,PITX2,PKD2,RECK,RGMA,SEMA3E,SMAD6,SMOC1,SORT1,TAGLN,TBX3,TMEM64,TOB2,WNT5A | 1046 (7) |
| Go 6976 | NA | chemical drug | Activated | 3.11e+00 | NA | 0.0e+00 | ABCA1,ABCA7,ACTA1,BCL2L1,Ccl2,CCND1,CD83,CDKN1A,CXCL10,CYBB,ETS1,FAM3B,FN1,ITGA5,LAMP2,MMP2,MYH7,NFKBIA,NR4A2,PLD1,PTGS2,TNFRSF4,VCAM1 | 854 (14) |
| halofuginone | NA | chemical drug | Activated | 3.11e+00 | NA | 0.0e+00 | AACS,ACP5,ADD3,AKAP12,BGN,BHLHE40,CD200,CD44,CHRND,CLIP2,COL1A1,CP,CPA3,CPQ,CSNK1D,CTHRC1,CTSK,CTSS,CXCL10,CYGB,DBN1,DKK3,EDNRB,EGR1,EHD3,ELN,EMP1,EPHX1,F2R,FBLN5,FBN1,FN1,FSTL1,FXYD6,GATM,GNG11,GPX3,HK1,IL17A,IL33,LGALS1,LOX,LRAT,LTBP1,MMP2,MS4A2,NAB2,NFE2L2,PCOLCE,PDGFRA,PKM,PLPP3,PMP22,PRELP,PROM1,PTGFRN,RGCC,Scd2,SCN1B,SLC39A8,SMAD7,SPARC,SPP1,TAGLN,TGFB1,TIMP1,TYRO3,VCAM1,VSNL1,WNT5A | 1351 (18) |
| beta-carotene | NA | chemical - endogenous mammalian | Activated | 3.11e+00 | NA | 2.1e-01 | ARRDC3,FADS3,HSPA1A/HSPA1B,LPL,NPR3,PPARG,PTGS2,Scd2,SKP2,THBD | NA |
| cyclopamine | NA | chemical reagent | Activated | 3.11e+00 | NA | 0.0e+00 | CCND1,CDKN1A,GLI1,GLI2,MKI67,MYCN,MYOD1,NKX6-1,OCLN,PTCH1,PTGS2,SERPINE1,SMO,SMPD3,SPARC,SPP1 | 1158 (13) |
| miR-218-5p (and other miRNAs w/seed UGUGCUU) | NA | mature microRNA | Activated | 3.10e+00 | bias | 0.0e+00 | CASP3,CDH1,COL1A1,FCGR3A/FCGR3B,LPCAT1,RUNX2,SNAI2,VIM,VOPP1,ZEB2 | 468 (7) |
| SP600125 | NA | chemical drug | Activated | 3.10e+00 | NA | 0.0e+00 | ABCA1,ACTA2,ADAMTS9,ALOX5,ATF3,ATP6AP2,BCL2L1,BCL2L11,BDH1,BTG2,CASP3,Ccl2,CCND1,CD44,CD83,CD86,CDH1,CDH2,CDK5R1,CDKN1A,CHAC1,CKAP4,COL1A1,COL7A1,COL8A1,CRYM,CSF1R,CSPG4,CTHRC1,CXCL10,CXCL16,CXCR4,CYGB,DDIT4,DDIT4L,DUSP1,EGR1,EMB,F3,FBXO32,FGF1,FLRT3,FN1,FOXO1,FOXP3,GADD45A,GATA4,GBP2,H2AC18/H2AC19,ICAM1,IGF1,IL17A,IL1R1,IL1RN,IL2RA,IL34,INHBA,IRS1,ISG15,ITGA2,ITGA3,ITGA6,ITGB4,LGALS9B,MAP1LC3B,MTHFD2,MYH3,MYH6,MYH7,MYOD1,MYOG,NEDD9,NFKBIA,NOX1,NR0B2,NR4A1,OCLN,PDGFD,PDGFRA,PER1,PLA2G4A,PLK2,PPARG,PRDX1,PROM1,PTGES,PTGS2,PTX3,RETN,RFC2,RGS4,RUNX1,RUNX2,Scd2,SELE,SELP,SERPINE1,SERPINH1,SNAI1,SNAI2,SOCS3,SOX7,SP110,SPARC,SPHK1,SPP1,SREBF1,TGFB1,THBS1,THBS2,TLR4,TNFRSF10A,TNNT2,TRIM63,TRPC6,TTC30B,TWIST1,VCAM1,ZFP36 | 1510 (17) |
| EWSR1-FLI1 | NA | fusion gene/product | Activated | 3.08e+00 | NA | 0.0e+00 | AK5,ARID5B,BCL2L1,BIRC3,CAV1,CCND1,CDKN1A,COL3A1,COL5A2,EDN1,EGR3,FIBIN,GAS2,IGFBP5,KAZN,LIMCH1,LOXL1,MAP2,MYH10,NRXN2,NUAK1,PCDH18,PDGFRA,PDGFRL,PMEPA1,PTPRO,RHOBTB1,SAMD5,SDC2,SELENOP,SERPINE1,SH3D19,TAGLN,THBS1,TLE1,ZFHX4 | 699 (9) |
| GPX1 | -3.50e-01 | enzyme | Activated | 3.08e+00 | NA | 1.2e-01 | ACTA2,ADGRE1,Ccl2,CXCL10,CYBB,FADD,GLRX,GPX3,ICAM1,TRADD,VCAM1 | NA |
| PKD1 | -2.90e-01 | ion channel | Activated | 3.06e+00 | NA | 0.0e+00 | ADCY7,ALDH1A1,ALDH8A1,ALG6,ATP1A1,ATP1B1,ATP1B2,AXL,BCAT1,CALCR,Ccl2,CDKN1A,COL12A1,CPEB3,CXCL16,EDIL3,EIF4EBP1,FAM151A,FGF10,FGFR1,FOXO1,GATM,GLDN,GLI2,GPRASP1,GREM1,HDAC9,IDH1,IFNLR1,IL1RL1,IL4I1,KLKB1,LOX,LTBP1,MCUB,MID1,NEDD9,NIPAL1,NNMT,PCDH7,PDCL,PITX2,PKD2,PRDX5,PRKCB,PVALB,QPCT,RAB9B,RADIL,RHOA,RUNX2,SERPINF2,SLC26A7,SLC2A9,SOX6,TENM2,TNFAIP8,TNFRSF11B,VWF,ZFHX4 | 1112 (7) |
| GLIS2 | -1.77e+00 | transcription regulator | Activated | 3.05e+00 | NA | 0.0e+00 | C3,Ccl2,CCND1,COL1A1,CXCL10,IL33,LTBP2,MMP14,SERPINE1,SNAI1,SNAI2,SPARC,TGFB1,VIM | 1351 (18) |
| LATS2 | -3.60e-01 | kinase | Activated | 3.05e+00 | NA | 1.3e-01 | ALDH1A3,CDH1,CDKN1A,DHH,ERBB3,GFAP,KIT,KRT19,NRCAM,PLK1,PTGS2,SNAI1,SPP1,STAR | NA |
| ACKR2 | -1.34e+00 | G-protein coupled receptor | Activated | 3.04e+00 | NA | 3.0e-02 | Ccl2,CXCL10,DHX58,IFI16,IFI44,Ifi47,IL17A,ISG15,OAS3,OASL,Oasl2,RSAD2,STAT1,USP18 | NA |
| REST | 2.30e-01 | transcription regulator | Activated | 3.04e+00 | NA | 1.2e-01 | ALOX5,AMPD3,ARRDC3,BDNF,CMKLR1,COTL1,CXCL12,EFNA5,GAD1,GAP43,GATA4,GRIA2,GRIK4,ITGAL,JAM2,KCNQ2,KIAA1549L,L1CAM,LRRTM4,mir-133,MYOG,NPTXR,NRP1,PAX3,PENK,PHKB,RGS7,S100B,SCTR,SNAI1,SOX18,SYP,TNNT1,TRPM2 | NA |
| acetovanillone | NA | chemical drug | Activated | 3.03e+00 | NA | 0.0e+00 | CACNA1G,CCND2,CXCL10,CXCL12,DUSP1,EDN1,F3,HIF1A,MAPK14,MMP2,MSR1,NCF1,NCF2,NOX1,OLR1,PTGS2,PVALB,SERPINE1,TAGLN,UCP3 | 1045 (14) |
| CTLA4 | -2.00e-02 | transmembrane receptor | Activated | 3.03e+00 | NA | 2.0e-02 | AHR,CCNA2,CD83,CD86,CXCL10,FOXP3,GZMB,ICAM1,IL2RA,MKI67,PRDM1,PTPRJ,RAB30,SELE,SELP,STX11,TGFB1,TOP2A,ZFP57 | NA |
| SU6656 | NA | chemical toxicant | Activated | 3.02e+00 | NA | 0.0e+00 | ATF3,Ccl2,Ccl7,CCND1,CSF1,EGR1,GFPT2,IER3,IL1RL1,INHBA,mir-143,Mt1,NFIL3,NR4A2,PHLDA1,PTGS2,SOCS3,TNFRSF11B,UCK1,ZFP36L1 | 1030 (19) |
| silibinin | NA | chemical drug | Activated | 3.01e+00 | NA | 0.0e+00 | CASP3,CCND1,CD44,CDH1,CDH2,CDK2,CDK6,CDKN1A,EGR1,FN1,HIF1A,KLF4,MMP2,NFKBIA,PROM1,PTGS2,RETN,SLC2A1,SNAI1,SNAI2,VIM,ZEB2 | 1354 (18) |
| miR-338-3p (miRNAs w/seed CCAGCAU) | NA | mature microRNA | Activated | 3.01e+00 | bias | 0.0e+00 | ADAMTS15,ADAMTS2,CCND1,COL1A1,COL5A1,COL5A2,COL8A1,LOXL2,LOXL4,NID1,PDGFB,PLOD2,SPARC,TAGLN,Tpm1,VCAN,VIM | NA |
| MGA | -9.00e-02 | transcription regulator | Activated | 3.01e+00 | bias | 4.0e-02 | ALDH1A3,BTG2,CCND1,CP,CXCL10,CYP2S1,GPD1,GSAP,ITGA1,MGST1,RALGDS,RNF157,SELENOP,SNAI1,TDRD1,TWIST1 | NA |
| COL5A1 | -1.20e+00 | other | Activated | 3.01e+00 | NA | 0.0e+00 | ACTA2,COL11A1,COL12A1,COL5A2,COL8A1,CTSC,FBLN5,FBN1,FN1,ITGB3,LGALS1,LOX,LOXL1,LOXL2,LTBP2,PKM,S100A6,SRPX2 | 570 (7) |
| valsartan | NA | chemical drug | Activated | 3.00e+00 | NA | 0.0e+00 | ADIPOQ,ANGPT2,AQP4,Ccl2,CD34,COL1A1,CTSS,CYBA,CYBB,EDN1,EGF,ENG,F3,FGF2,FHOD3,FN1,GFAP,ICAM1,KIT,MMP2,MRC1,NCF1,NOX1,PPARG,PTGS2,SERPINE1,SPP1,TGFB1,TIMP1 | 1631 (21) |
| 3,5-diiodothyronine | NA | chemical - endogenous mammalian | Activated | 3.00e+00 | NA | 0.0e+00 | AK1,CD36,CKM,ENO3,GAPDH,IDH3A,Ldha/RGD1562690,PGM1,Tpi1 (includes others) | 831 (13) |
| GMNN | -4.80e-01 | transcription regulator | Activated | 3.00e+00 | bias | 0.0e+00 | ACVR1,APCDD1,CDH1,CDKN1A,CHST15,COBLL1,DUSP1,DUSP5,ECSIT,FABP1,FARP1,FGF2,FRZB,GBP4,IER5,INHBA,IRS1,NRP1,Oasl2,PCDH18,PDGFRA,PITX2,TNFRSF19,TWIST2,USP18,WLS,WNT5A | 1354 (12) |
| CFTR | 2.30e-01 | ion channel | Activated | 2.99e+00 | NA | 0.0e+00 | ABCA1,ASNS,CAV1,Ccl2,CFH,CFI,CPA3,DMBT1,FAAH,FADS1,FADS2,GSR,HSD17B4,LRG1,NFKBIA,OXCT1,PLA2G5,PTGS2,Scd2,SLC37A4,SLC7A8,SLC9A3,Slfn2,SOCS3,STAT1,TIMP1 | 1367 (16) |
| IL15RA | 1.19e+00 | transmembrane receptor | Activated | 2.98e+00 | NA | 1.0e-02 | CD226,CD244,CD44,CD84,EDN1,IL17A,IL2RA,PTPRC,SPN | 1329 (20) |
| IDR-1002 | NA | chemical reagent | Activated | 2.97e+00 | NA | 0.0e+00 | C3AR1,Ccl2,Ccl6,Ccl7,CSF3R,HRH2,ITGA5,NCF1,NLRP3,PTAFR,PTGIR,TLR4 | NA |
| ANXA1 | -1.74e+00 | enzyme | Activated | 2.95e+00 | NA | 0.0e+00 | ACTA2,ALOX15,ANGPT2,ANXA1,ANXA2,CD83,CD86,CDH1,COL18A1,COL1A1,CSF1,CXCR4,IL17A,IL2RA,ITGB2,LGALS1,MMP2,PLA2G4A,PTGS2,SPHK1,TGFB1,TIFA,TLR4,VEGFD | 1101 (13) |
| CBX7 | 1.50e-01 | other | Activated | 2.93e+00 | bias | 0.0e+00 | ALDH1A3,ANKRD1,CBX2,CCND1,CD44,CDH1,CDK6,CLDN1,CTSS,CYP1B1,FER1L6,MMP2,PRDM1 | 841 (7) |
| HLX | 6.20e-01 | transcription regulator | Activated | 2.92e+00 | NA | 1.0e-02 | ANKRD1,CD34,CD44,CLDN1,CTSS,CYP1B1,EGR1,FER1L6,ICAM1,PRDM1,THY1,UNC5B | 880 (7) |
| H89 | NA | chemical drug | Activated | 2.91e+00 | NA | 0.0e+00 | ABCA1,ADIPOQ,ADORA2A,ANXA1,BCL2L1,BDNF,BMP4,Ccl2,CCND1,CD83,CD86,CDKN1A,COL2A1,CREB1,CREM,DMP1,DUSP1,EGR1,EGR2,EGR3,ENTPD1,EZH2,FAM3B,FGF2,IGF1,IGFBP5,MITF,MKI67,MMP2,NFIL3,NFKBIA,NOS1,NR4A1,NR4A2,NTS,PDE3B,PLA2G4A,PLAGL1,PLD1,PPARD,PTGS2,RUNX1,SDC1,SERPINE1,STAR,TFPI2,TGFA,TNFAIP6,TPH1,VCAM1 | 1424 (19) |
| calphostin C | NA | chemical drug | Activated | 2.90e+00 | NA | 0.0e+00 | ACTA2,AXIN2,BCL2L1,CCND1,CD36,CDKN1A,DUSP1,ETS1,ICAM1,KIT,LPL,MAOB,MSR1,NTN1,PDIA4,POU2F2,PPARG,PTGS2,SLC2A1,STAR,USF2 | 1194 (17) |
| TNFAIP3 | -3.00e-01 | enzyme | Activated | 2.90e+00 | NA | 2.0e-01 | BCL2L1,BIRC3,Ccl2,CSF1,CXCL10,ICAM1,NFKBIA,NLRP3,SELE,SOCS3,TGFB1,VCAM1 | NA |
| rottlerin | NA | chemical drug | Activated | 2.90e+00 | NA | 0.0e+00 | ABCA1,ATP6AP2,BIRC3,Ccl2,CCND1,CDK6,CDKN1A,CIITA,CLDN1,COL1A1,COL3A1,EEF2K,FKBP5,ICAM1,LPL,MMP2,MPZ,OCLN,PDGFB,PLD1,PRDX1,PRKCD,PTGS2,RGS2,VCAM1,ZFP36 | 1151 (16) |
| CR1L | -2.40e-01 | transmembrane receptor | Activated | 2.89e+00 | NA | 0.0e+00 | BGN,C3,COL18A1,COL1A1,COL3A1,COL5A1,COL6A3,COL8A1,FBN1,LUM,SERPINE1,TGFB1,TNC | 1173 (18) |
| miR-125b-5p (and other miRNAs w/seed CCCUGAG) | NA | mature microRNA | Activated | 2.89e+00 | bias | 0.0e+00 | ABTB1,ADAMTS1,ALOX5,ANAPC16,APLN,ARG1,ARID3B,CASP3,CBFB,Ccl2,CCNA2,CCR5,CD44,CDK6,ELAVL1,ERBB3,GPR160,ID2,IL1RN,KRT19,LCP1,MAN1A1,MAPK14,PCTP,PROM1,SMO,TENM2,TSPAN8,VSIR,ZNF385A | 1609 (18) |
| LATS1 | -3.40e-01 | kinase | Activated | 2.89e+00 | NA | 1.2e-01 | ALDH1A3,CDH1,DHH,ERBB3,GFAP,KIT,KRT19,NRCAM,PTGS2,SNAI1,SPP1,STAR | NA |
| SAFB | 5.90e-01 | other | Activated | 2.89e+00 | NA | 2.0e-01 | B2M,CD74,CDH1,CX3CL1,CXCL10,GULP1,HLA-DRA,IGF1,L1CAM,NEDD9,SAFB2,TNFRSF11B | NA |
| DMH1 | NA | chemical reagent | Activated | 2.89e+00 | NA | 0.0e+00 | ACTA2,ADAM17,BDNF,CAV1,INHBA,LOX,LOXL2,MMP2,MRC1,PTGS2,STAR,VEGFC | NA |
| SOX3 | NA | transcription regulator | Activated | 2.89e+00 | NA | 0.0e+00 | ACVR1,APCDD1,CHST15,COBLL1,DLL1,DUSP1,DUSP5,ECSIT,FABP1,FARP1,FRZB,GBP4,IER5,INHBA,IRS1,NR5A1,NRP1,Oasl2,PCDH18,PDGFRA,PITX2,RET,TNFRSF19,TWIST2,USP18,WLS,WNT5A,ZBTB16 | NA |
| IMMT | 3.80e-01 | other | Activated | 2.89e+00 | bias | 2.0e-02 | AXL,CD276,CXCL10,IFIT1,IGFBP6,INHBA,ISG15,KITLG,MX1,OAS3,SERPINE1,VEGFC | NA |
| clopidogrel | NA | chemical drug | Activated | 2.86e+00 | NA | 0.0e+00 | ACKR3,ALDH1L2,ASNS,ATF3,C1QTNF6,Ccl2,CHAC1,COL1A1,COL5A1,CRP,CXCL12,DUSP10,F3,GPT2,HERPUD1,HOXA5,IFIT1,KLF15,MMP2,NR2F1,PTX3,SLC1A4 | 705 (7) |
| birabresib | NA | chemical drug | Activated | 2.86e+00 | NA | 0.0e+00 | ACKR3,ADAMTS1,ANK2,BCAT1,CHRNA1,EYA2,HOXC5,HS6ST2,IFI44,IFI44L,KCTD15,KIF11,LDB2,MAMDC2,MYCN,PDE1A,PTPRF,SERPINF1,TEX14,USP18,VCAM1 | NA |
| ARID2 | -1.80e-01 | transcription regulator | Activated | 2.85e+00 | NA | 0.0e+00 | ACVR1,ADAM17,ADAM19,BMP4,CALCR,CHST11,COL1A1,COL8A1,DAB2,EIF6,EXT1,FOXP3,HEG1,HTR7,SNAI1,SSC5D,THBS1,WNT5A | 1197 (18) |
| TXNRD1 | -4.00e-02 | enzyme | Activated | 2.84e+00 | NA | 0.0e+00 | ABCC3,Abcg3,AOX1,BLVRB,CD36,ESRRG,GCLC,GPX3,Gsta4,LPIN1,SLC2A1,TKT,TNFRSF10A,TNFRSF25,UGDH | 1294 (12) |
| ZFP91 | 2.50e-01 | transcription regulator | Activated | 2.83e+00 | NA | 0.0e+00 | BCAT1,CASP1,CCNA2,FADS2,IFI16,Scd2,STMN1,TNFRSF8 | NA |
| V-PYRRO/NO | NA | chemical reagent | Activated | 2.83e+00 | bias | 2.0e-02 | CASP1,CASP3,CASP8,EGR1,ICAM1,THBS1,TNFRSF1B,TRADD | NA |
| KRAS | 1.00e-01 | enzyme | Activated | 2.83e+00 | NA | 0.0e+00 | ABCA1,ABCC4,ABCC5,ABCG1,ACVR1,ADAMTS1,ADAMTS5,AEN,AHR,ALDOA,AMPD3,ANK1,ANPEP,ANXA8/ANXA8L1,AOX1,ARG1,ARHGDIB,ARHGEF2,ATAD3A,ATF3,ATP1B1,AXIN2,AXL,B2M,B3GALNT1,B3GALNT2,BCL2A1,BCL2L1,BDH1,BGN,BIRC3,BMP4,Cald1,CASP1,CASP3,CAV1,CCDC8,CCDC80,Ccl2,CCNA2,CCND1,Cd33,CD44,CD74,CDH1,CDH11,CDH2,CDH3,CDKN1A,CDKN2C,CEACAM1,CFL1,CHI3L1,CHST3,CHSY1,COL1A1,COL3A1,COL5A1,CRYAB,CSF2RA,CSF2RB,CSF3R,CX3CL1,CXADR,CXCL10,CXCL12,CXCL14,CXCR4,CYBB,DBN1,Dclk1,DDAH1,DDR1,DLC1,DPY19L3,DPYSL2,DSE,DUSP1,DUSP5,DUSP6,E2F5,EDEM1,EEF1A1,EGFL6,EGR1,EGR2,EIF2AK3,EIF3G,EIF6,ELMO1,ELN,EMP2,ENO2,EPHB4,EPN3,ERAP1,ETV1,ETV5,EXOSC5,EXT1,EZH2,F2RL1,F3,FBN1,FCGR2B,FGF10,FGFR1,FKBP11,FLNA,FLT3LG,FN1,FOXP3,FSTL1,G6PD,GADD45A,GALNT10,GAPDH,GCLC,GCNT1,GFAP,GGT5,GLI1,GLI2,GLUL,GNA13,GPC3,GPR68,GXYLT2,HIF1A,HOPX,HOXA5,HSPE1,IER3,IFIT1,IFITM3,IKBKB,IL17A,IL33,IP6K2,IQGAP2,IRF1,ISG15,ITGB2,ITGB3,ITM2A,KAT5,KLF6,L1CAM,LAMA2,LAMA3,LAMA4,LAMC2,LAMP2,LBH,LEF1,LGALS9B,LIPG,LMO2,LOX,LUM,MADD,MAN2A1,MAP1LC3B,MAPK14,MAPK3,MCOLN1,MCTP1,MET,MFAP5,MICB,MME,MMP2,MRC1,MSLN,MSN,MSR1,MX1,MYCN,MYOF,NCAM1,NCEH1,NCF1,NCF2,NCF4,NDRG4,NFE2L2,NFKBIA,NFKBIB,NGEF,NKD1,NLRP3,NMNAT1,NOS1,NOX1,NR4A1,NR5A2,NUAK2,NUDC,NUDT5,NUP210,NXN,Oasl2,OCLN,PALD1,PALLD,PALM,PAWR,PC,PCDH7,PCOLCE,PDGFRA,PDPN,PECR,Peg3,PGAM2,PHLDB2,PIP4K2B,PKM,PLA1A,PLAGL1,PLAT,PLD1,PLEKHO2,PLK1,PMP22,PPARD,PRAF2,PRC1,PRDX4,PRKCD,PRKCI,PSTPIP1,PTCH1,PTGS2,PTPN6,PTPRC,PTPRF,PTX3,PYCARD,PYGM,QTRT1,RAB27A,RAB7A,RANBP1,RHOA,RNASE4,ROCK1,RUNX1T1,S100A4,S100A6,SDC4,SEMA7A,SERPINE1,SFTPB,SH2D4A,SH3BGRL,SIRPA,SKP2,SLC20A1,SLC25A6,SLC27A6,SLC2A1,SLC36A2,SLC7A1,SLC7A10,SLCO4A1,Slfn2,SLIT3,SMPD3,SNAI1,SNAI2,SNX16,SOAT1,SOCS3,SORT1,SPARC,SPP1,SPRED2,SREBF1,SRSF3,ST3GAL1,ST3GAL6,ST6GAL1,STAT1,STRA6,SUSD5,TCOF1,TESC,TGFA,TGFB1,THBD,THBS1,THY1,TIMM9,TINAGL1,TLR2,TMEM259,TNC,TNFAIP2,TNFRSF10A,TNFRSF11B,Tnfrsf26,TOP2A,TP63,Tpi1 (includes others),Tpm1,Tpm3,TRIB1,TSPAN1,UGT8,UNC5B,VCAN,VCP,VEGFD,VIM,WEE1,WNT2,ZFP36L1 | 1447 (16) |
| U73122 | NA | chemical reagent | Activated | 2.82e+00 | NA | 0.0e+00 | ATP2A2,CCND2,E2F2,FN1,ICAM1,KLF15,MAF,MMP14,MMP2,NOS1,NR4A1,OXTR,PLCB1,PTGS2,RHOA,SELE,TLR4,VCAM1 | 905 (13) |
| CDH1 | -2.48e+00 | other | Activated | 2.81e+00 | NA | 0.0e+00 | BMP4,CASP3,CCND1,CD44,CDH1,CDH2,CDH3,CDK6,EIF4EBP1,ERBB3,FN1,GLI1,GLI2,ITGB3,KRT19,MMP14,MMP19,NCAM1,OCLN,PFKFB3,PIK3R1,S100A4,SKP2,SNAI2,TGFB1,TPBG,VIM | 1448 (22) |
| SFTPA1 | 2.00e-02 | transporter | Activated | 2.81e+00 | NA | 0.0e+00 | ADRB2,ANPEP,Ccl2,COL1A1,CXCL10,CYP1B1,ECM1,EGR1,ESM1,EVI2B,FOXP3,GFPT2,GPR68,HBA1/HBA2,IL1RL1,IL2RA,KCNMB4,LOX,MAP1B,MRC1,PDK4,PHLDA1,SERPINE1,SFRP2,SLC22A3,ST3GAL1,TCEA3,TGFB1,TWIST1 | 1444 (15) |
| GFI1 | 1.70e-01 | transcription regulator | Activated | 2.80e+00 | NA | 0.0e+00 | BCL3,CARD6,CASP1,CASP8,Ccl2,CCND2,CD53,CD7,CDKN1A,CHD7,CSF1,CXCR4,DGKG,E2F5,EGR2,ENTPD1,ETS1,F2R,FOXO1,GADD45G,GIMAP4,GPR183,HDAC4,ICAM1,ID2,IKBKB,IL1R1,IRAK2,IRF1,ITGB3,ITGB7,JAK3,LPAR1,MAFF,MAPK3,NFKBIA,PER3,Pmaip1,RAPGEF4,RASGRP1,REL,RIPK2,SGK1,SLFN13,STAT1,TESC,TNFRSF25,TNK2,TRADD,TRAF5 | 1005 (11) |
| ADAM12 | -3.50e-01 | peptidase | Activated | 2.79e+00 | NA | 0.0e+00 | ADAMTS15,ADAMTSL5,ADIPOQ,C1QTNF3,Ccl2,CCL24,Ccl7,COL11A1,COL5A2,COL6A3,CX3CL1,DCN,FBLN7,FBN1,GREM1,HGF,IGFBP5,IGFBP6,IL1RL1,IL33,LOXL4,LUM,MFAP5,MYOD1,MYOG,OGN,OLR1,PARM1,PPARG,SERPINE1,SFRP2,SFRP5,SVEP1,TGFBI,VWF | 1189 (16) |
| HEY1 | 6.50e-01 | transcription regulator | Activated | 2.78e+00 | NA | 0.0e+00 | ACTA2,CDKN1A,CNN1,GATA4,IL7,KDR,MMP2,MYH6,MYOG,NR2F2,PROX1,TAGLN,TNFSF8 | 1391 (18) |
| mir-33 | NA | microRNA | Activated | 2.77e+00 | bias | 3.0e-02 | ABCA1,ABCG1,ADIPOQ,CDK6,IRS2,LPL,PPARG,PRKAA1 | NA |
| MCC950 | NA | chemical reagent | Activated | 2.77e+00 | NA | 4.0e-02 | CASP1,Ccl2,CXCL10,IL7,NLRP3,PYCARD,TGFB1,TIMP1 | NA |
| mir-7 | NA | microRNA | Activated | 2.77e+00 | NA | 4.0e-02 | CDH2,IRS2,KLF4,PIK3R3,SNAI1,SNAI2,TWIST1,VIM | NA |
| bicalutamide | NA | chemical drug | Activated | 2.76e+00 | NA | 2.0e-02 | CDH1,CDH2,DDIT4,EZR,F5,FKBP5,GATA4,HUS1,MMP2,MYOD1,PMEPA1,SEC24D,SORD,TMPRSS2,VIM | NA |
| mir-155 | NA | microRNA | Activated | 2.75e+00 | NA | 0.0e+00 | ACTA2,ADAM10,ALDOA,ANXA2,ARG1,BCL6,CCND1,CD47,CDKN1A,CLDN1,COL1A1,CXCL10,DNAJB1,DUSP5,EDN1,FADD,FOXO3,GAPDH,GCSAM,GPI,HIF1A,IKBKE,IL17A,IL7,INPP5D,IRAK3,IRF4,IRF8,MAF,mir-143,MME,MRC1,MX1,PKM,PPARG,PSIP1,PTGS2,SERPINE1,SNAI1,SOCS1,SOCS3,STAT1,TGFB1,TWIST1,WEE1,ZNF652 | 1428 (15) |
| ABCG1 | -1.61e+00 | transporter | Activated | 2.75e+00 | NA | 2.6e-01 | Ccl2,CCR5,CXCL13,CYP7B1,IL10RA,IL10RB,IL17A,PIK3R1,SLC2A1,TGFB1,TLR4 | NA |
| miR-26a-5p (and other miRNAs w/seed UCAAGUA) | NA | mature microRNA | Activated | 2.75e+00 | bias | 1.0e-02 | CCND2,CCNE2,CDK6,CDKN1A,EZH2,FGF9,HGF,MAP2,PHF6,PLCB1,PTGS2 | NA |
| FOXA1 | NA | transcription regulator | Activated | 2.74e+00 | NA | 1.0e-02 | ACTA2,ACTC1,ACTG2,ADH1C,ANXA1,ARHGEF9,CDH1,CDKN1A,CNN1,COL18A1,CXCL10,DDIT4,DSE,EFHD1,ELK3,EPHX1,ERBB3,FMN1,FOXC1,FSTL1,GBP2,GRIN3A,HK1,JAG1,KDM4B,LYN,MYOCD,NR4A2,PAM,PFKFB1,RARA,SIAH2,SLC10A6,SNAI2,SPDEF,TACR3,TAGLN,THBS3,TMPRSS2,TNNI1,UST | 1438 (20) |
| GAPDH | 1.08e+00 | enzyme | Activated | 2.73e+00 | NA | 7.0e-02 | BCL2L1,C2,DUSP1,FCER1G,GAPDH,OAS3,RIPK3,SLC38A2,SPP1,STAT1,UBE2L6 | NA |
| USP18 | -8.00e-01 | peptidase | Activated | 2.72e+00 | NA | 1.0e-02 | BCL2L11,Ccl2,CTSK,CXCL10,IFIH1,IFITM3,IRF1,ISG15,MX1,SOCS1,SOCS3 | 1228 (19) |
| resveratrol | NA | chemical drug | Activated | 2.72e+00 | NA | 0.0e+00 | ACTA2,ADAM17,ADIPOQ,AIF1,ALOX5,ATF3,BCL2A1,BCL2L1,BDNF,BIRC3,CASP3,Ccl2,CCNA2,CCND1,CCND2,CD36,CD86,CDH1,CDK2,CDK6,CDKN1A,COX4I1,CSF1R,CTSK,CX3CL1,CX3CR1,CXCL10,CYBB,CYP1B1,CYP4F2,DAPK1,DYNLL1,EDN1,EGLN1,EGR1,F3,FN1,FOXO1,FOXO3,FXN,GLI1,HAS2,HEY2,HIF1A,ICAM1,IFIT1,IL17A,IL2RA,ISG15,ITGA1,ITGA2B,ITGAL,JAG1,JUND,KDR,LITAF,MAPK14,MICB,MITF,MMP2,MRC1,NFKBIA,NFKBIB,NOX1,PDGFB,PDK4,PKM,PLIN1,PPARG,PPP1R13B,PRKAA2,PSMB5,PTCH1,PTGS2,ROCK1,SCX,SELP,SERPINE1,SPHK1,SPP1,STAR,TGFB1,TNFAIP6,TNFRSF10A,TNFRSF11B,TNMD,VCAM1,VIM | 1543 (17) |
| BCOR | -3.20e-01 | transcription regulator | Activated | 2.71e+00 | bias | 0.0e+00 | ADAMTS1,ARID5B,BANK1,CD37,CD44,CD74,CDKN1A,CIITA,COL18A1,COL2A1,GJB2,HOXC5,IGFBP5,IRF4,ISG15,ITGA6,PRDM1,PTCH1,SMARCD3,TLR4,ZNF503 | 1097 (17) |
| estriol | NA | chemical - endogenous mammalian | Activated | 2.71e+00 | NA | 1.2e-01 | Ccl2,Ccl7,CCR1,CXCL10,IL1RN,IRS1,IRS2,ITGB2,PIK3R1,SELE,TLR7 | NA |
| FOXA2 | NA | transcription regulator | Activated | 2.71e+00 | NA | 0.0e+00 | A2M,ABCC8,ACTA2,ACTC1,ACTG2,ADH1C,ALOX15,ALOX5,C3,CA3,CCL24,CCND1,CCR5,CDH1,CFAP126,CHI3L1,CNN1,CTHRC1,CXCR4,DDIT4,DLK1,EPHX1,FOXO1,GATA4,GPRC5C,GRIN3A,IGF1,IGFBP5,IL33,ITGA3,JOSD2,KCNJ11,LPL,MAFA,MAP1B,Mt1,MYOCD,NKX6-1,NR4A2,NR5A2,PKM,PPARG,PROS1,RARA,RARG,SFTPB,SLC10A6,SMOC1,SNAI1,TACR3,TAGLN,TBXAS1,TGFB1,THBS3,TMPRSS2,TNNI1,UCP3,UST,VIM,WNT5A | 1628 (24) |
| KN 93 | NA | chemical drug | Activated | 2.71e+00 | NA | 0.0e+00 | ABCA1,CAMK2A,Ccl7,CCND1,CD83,COL3A1,ETS1,GAD1,HAS2,IL17A,MMP2,MYOG,NR4A1,NR4A2,PEA15,SELE,SELP,VCAM1 | 1106 (19) |
| mir-1 | NA | microRNA | Activated | 2.70e+00 | NA | 0.0e+00 | ANXA2,BDNF,CACNB2,CASP3,CCND1,CCND2,CDK14,CNN3,CREB1,CXCL12,E2F5,EDN1,EIF4E3,FBXO32,FN1,HACD3,HCN4,HDAC4,HNRNPU,IGF1,Irx5,LASP1,MAN1C1,MET,MYOD1,MYOG,NXT2,PFKFB3,PPIB,RNF38,SERP1,SFRP1,SNAI2,TAGLN2,TNNT2,TRIM63,TWF1,UNC119B,UST,UTRN,VEGFC,WBP1L,ZFP36L1 | 664 (7) |
| Scd2 | -1.96e+00 | enzyme | Activated | 2.69e+00 | bias | 0.0e+00 | F830016B08Rik,GBP7,HDC,HERC6,ISG15,NMI,OAS3,OASL,PARP14,PPARG,RSAD2,SLFN13,ZC3HAV1 | 987 (11) |
| HEY2 | -2.30e+00 | transcription regulator | Activated | 2.68e+00 | NA | 0.0e+00 | ACTA1,ACTA2,ANKRD1,CNN1,CX3CL1,GATA4,GJA5,IL34,IL7,MYH6,MYH7,NR2F2,PROX1,SCN5A,TAGLN,TBX5,TNFSF8 | 903 (13) |
| miR-335-3p (miRNAs w/seed UUUUCAU) | NA | mature microRNA | Activated | 2.67e+00 | bias | 0.0e+00 | ADAMTS15,ADAMTS2,COL1A1,COL5A1,COL5A2,COL8A1,LOXL2,LOXL4,NID1,PDGFB,PLOD2,SPARC,Tpm1,VCAN | NA |
| ZFP36 | 1.46e+00 | transcription regulator | Activated | 2.67e+00 | bias | 0.0e+00 | ABCG4,AHRR,BIRC3,CCNE2,CD36,CDKN1A,CLCN3,CLMP,COL3A1,CTSS,CYBB,E2F8,HIF1A,ICAM1,IER3,IL17A,IRF1,KIF11,KIF18A,KNTC1,LMO2,MMP2,NFKBIA,PRC1,PRDM1,PTGS2,SOCS1,SOX6,SPP1,SS18L2,THBD,TLR4,TMCC2,TOP2A,VCAM1,VEGFC,ZFP36 | 838 (12) |
| spironolactone | NA | chemical drug | Activated | 2.65e+00 | NA | 0.0e+00 | ABCC3,ACTA2,ATP6AP2,BGN,BMP4,CASP3,Ccl2,CDKN1A,COL1A1,COL3A1,CXCR4,DCN,DUSP1,EDN1,EDNRB,FGF2,FKBP5,FN1,FOXP3,HCN4,ICAM1,IP6K3,LOX,MICB,PER1,PPARG,PRDM16,PTGS2,RUNX2,SLC9A1,Slco1a4,SLCO2A1,SLCO2B1,STAR,TGFB1,VIM | 1200 (16) |
| sunitinib | NA | chemical drug | Activated | 2.65e+00 | NA | 0.0e+00 | ADAMTS8,ANGPT2,BCL2L11,CCND2,CD44,CDKN1A,COL1A1,COL5A1,COL7A1,COL8A1,CXCL10,CXCR4,ECM1,FN1,ICAM1,IL2RA,ITGA1,ITGA3,ITGA4,ITGA6,ITGA8,ITGAL,ITGB2,ITGB3,KDR,LAMA3,MET,mir-143,PDGFB,RUNX1,TGFBI,TNC | 1278 (19) |
| paricalcitol | NA | chemical drug | Activated | 2.65e+00 | NA | 0.0e+00 | ATP6AP2,BCL2L1,CASP1,Ccl2,COL3A1,F2RL1,F3,FN1,GPX3,ICAM1,NLRP3,PTGS2,PYCARD,TGFB1,TIMP1,VCAM1 | 878 (15) |
| ebselen | NA | chemical drug | Activated | 2.65e+00 | bias | 1.0e-02 | ADGRE1,DUSP1,GCLC,HIF1A,ICAM1,PTGS2,TLR4 | NA |
| EFNA4 | -2.40e-01 | kinase | Activated | 2.65e+00 | NA | 5.6e-01 | DUSP6,ETV5,IRF1,ITGB4,NTM,PLAT,SLC20A1 | NA |
| EFNA3 | NA | kinase | Activated | 2.65e+00 | NA | 1.0e+00 | DUSP6,ETV5,IRF1,ITGB4,NTM,PLAT,SLC20A1 | NA |
| PRKAA1 | -8.90e-01 | kinase | Activated | 2.63e+00 | NA | 0.0e+00 | ACKR3,ACOT7,ACTA2,ARG1,ARHGDIB,ATF3,BIRC3,BTG1,CAMKK1,CDC42EP3,CDH3,CDKN1A,CENPF,COX4I1,CXCL12,DDAH1,EGF,EPHA3,FKBP5,FN1,FOXO3,GJB2,Gsta4,ID2,IFI44,Ifi47,IGF1,IGFBP4,IL17A,IL1R1,KCNA2,KCNQ2,KLHL29,LITAF,MAP2,MATN2,MGST1,MRC1,NCF1,NCF2,NFKBIA,NPEPL1,OCLN,PCOLCE,PDGFRA,PLA2G2A,PMEPA1,PPP1R3B,PRKAA2,RGS2,RND3,RTN4RL1,SIRT2,SLC16A1,SLC2A1,SOCS3,SPRED1,SPRED2,STAR,TTYH1,VCAM1,ZDHHC9,ZFP36L1 | 1418 (21) |
| miR-130a-3p (and other miRNAs w/seed AGUGCAA) | NA | mature microRNA | Activated | 2.63e+00 | bias | 4.0e-02 | AQP4,CSF1,DEPDC1,FGFR1,HOXA5,MEOX2,ZFPM2 | NA |
| eplerenone | NA | chemical drug | Activated | 2.62e+00 | NA | 0.0e+00 | ADIPOQ,Ccl2,COL1A1,CYBA,CYBB,EDN1,EDN3,FN1,ICAM1,MMP2,NCF1,NOX4,PPARG,PTGS2,SERPINE1,SPP1,TGFB1,VCAM1 | 1240 (17) |
| butylidenephthalide | NA | chemical reagent | Activated | 2.62e+00 | bias | 0.0e+00 | AXL,CDH2,MMP2,SNAI1,SNAI2,TWIST1,VIM | 611 (7) |
| KDM5B | -1.50e-01 | transcription regulator | Activated | 2.61e+00 | NA | 6.0e-02 | BUB1B,CAV1,CCND1,CDC14A,CLDN1,DPY19L1,ECT2,EGR1,EIF5B,EPB41L1,ERBB3,FHL1,GADD45A,GATA4,GCA,GJB2,HSD17B8,ID2,ISG15,LIMCH1,NEDD9,NEFL,PDE3B,PHF20,PIR,PLS3,PSIP1,SMOX,SWAP70,TAL1,TGFB1,TOP2A | NA |
| emodin | NA | chemical drug | Activated | 2.60e+00 | NA | 0.0e+00 | ADIPOQ,ARG1,Ccl2,CCR1,CD86,CDH1,CDKN1A,CSF1R,CXCL10,CXCR4,CYP1B1,ERCC1,FN1,HLA-DOB,ICAM1,IRF4,IRF5,LPL,MKI67,MMP2,MRC1,OCLN,SELE,SOCS1,TLR4,TWIST1,VCAM1,VIM | 1054 (14) |
| BPIFB1 | 1.40e-01 | other | Activated | 2.60e+00 | NA | 1.3e-01 | CCND1,CDH2,CDKL2,MMP2,NFKBIA,RASSF4,SLC2A1 | NA |
| DNASE2 | 0.00e+00 | enzyme | Activated | 2.60e+00 | bias | 0.0e+00 | ACKR4,CP,CXCL10,DHX58,GPNMB,ISG15,OAS3,Oasl2,RSAD2,RTP4,Sp100,USP18 | NA |
| napabucasin | NA | chemical drug | Activated | 2.58e+00 | NA | 0.0e+00 | ALCAM,ALDH1A1,AXL,B2M,CASP3,CD34,CD44,DACH1,DDR1,EGF,ENG,IKBKB,ITGA2,ITGA4,ITGA6,JAG1,KITLG,KLF4,NOTCH2,SMO,TWIST2,WEE1 | 549 (7) |
| PTX3 | 6.50e-01 | other | Activated | 2.58e+00 | NA | 1.0e-02 | Ccl2,Ccl7,CCR5,CX3CR1,EGR2,EGR3,F3,GATA4,IGF1,TLR2,TLR4 | 1014 (9) |
| carvedilol | NA | chemical drug | Activated | 2.58e+00 | NA | 0.0e+00 | ACTA2,ATP2A2,COL1A1,COL3A1,CYBA,F3,GAP43,MMP2,NPR3,SREBF1,TLR4,TNFRSF11B | 1242 (16) |
| miR-199a-3p (and other miRNAs w/seed CAGUAGU) | NA | mature microRNA | Activated | 2.57e+00 | bias | 0.0e+00 | CALU,CD44,CREB1,FN1,FUBP1,ITGA6,MET,PON2,PTGS2,RUNX1,VCAN | 1090 (12) |
| SCARB1 | -2.40e-01 | transporter | Activated | 2.56e+00 | NA | 0.0e+00 | ABCA1,ABCG1,APOD,CX3CL1,DDIT4,F3,FBXO32,FOXO1,ICAM1,IL1RN,NLRP3,PTGS2,SELE,SELP,SESN1,SIAH2,SPP1,SREBF1,TRIM63,VCAM1 | 1209 (19) |
| PDCD10 | -4.00e-01 | other | Activated | 2.56e+00 | bias | 0.0e+00 | ACTA2,ANXA5,F2RL1,F5,HIF1A,KLF4,RHOA,SERPINE1,THBD,THBS1,VWF | 1295 (18) |
| tetrodotoxin | NA | chemical drug | Activated | 2.56e+00 | NA | 0.0e+00 | ADAM19,AMIGO2,ATP1B1,B2M,BDNF,BMP3,CAMK1D,CATSPERG,CD200,CNKSR2,CXXC4,DCN,EGR1,ESRRG,ETV1,Fat4,Fn3k,GAD1,GDA,GPD2,GPR176,HDAC9,HPSE,ITGA8,KCNA1,KCNA2,LGI1,LUM,MAL2,Mt1,MTHFD2,MYH7,NTRK2,POPDC3,PTGS2,RCAN2,RNF152,ROBO2,SLC4A10,SLITRK1,SNCA,SNX16,SV2B,TACR3,THY1,TLL1,TMEFF1,TRHDE,TSPAN2,XK,ZNF180,ZNF25 | 1205 (24) |
| DSP | -5.10e-01 | other | Activated | 2.55e+00 | NA | 0.0e+00 | ADIPOQ,AXIN2,Ccl2,COL1A1,COL3A1,HRAS,LPL,MMP14,PPARG,TGFB1 | 1335 (15) |
| THZ2 | NA | chemical drug | Activated | 2.55e+00 | NA | 0.0e+00 | CCND1,CDKN1A,FHL2,GLI2,HRH1,IRAK2,RUNX2,SLC2A1,SRSF3,WEE1 | 638 (4) |
| estrogen receptor | NA | group | Activated | 2.55e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ADIPOQ,ANXA1,AXL,BDNF,C3,CA12,CALB1,CAV1,CAV2,CCND1,CCND2,CCNE2,CD44,CDH1,CDH11,CDH19,CDH3,CLDN3,CNKSR1,CNNM4,COL12A1,COL13A1,COL4A6,COL5A1,COL7A1,CXCL12,CXCR4,DCHS1,EDN1,EGLN2,EGR1,ERBB3,ETS1,FGF1,FGFR1,FN1,HRAS,HSP90AA1,HSPA1A/HSPA1B,ICAM1,IGF1,IRS1,ITGA3,JAG1,KIT,KLF10,KRT19,LAMC2,LOXL2,LYN,MAN1A1,MAP1B,MMP14,MMP15,MSN,NEDD9,OCLN,OXTR,PCDH18,PCDH7,PDGFC,PDGFD,PDK4,PPARG,PPP5C,RGS2,SERPINB9,SERPINE1,SMAD6,SNAI1,SNAI2,SPARC,SYP,TGFA,TGFB1,TIMP1,TLR4,TMEFF1,TMOD1,TNC,UGT8,VEGFC,VIM,WNT5A | 1902 (21) |
| imipramine blue | NA | chemical drug | Activated | 2.54e+00 | NA | 0.0e+00 | CCNA2,CCND1,CCNE2,CDK2,CENPF,CENPK,CYP4B1,E2F2,FOXRED2,GADD45A,PLK1,PLK4,SKP2,STMN1 | NA |
| NLRP12 | 1.00e-01 | other | Activated | 2.54e+00 | NA | 3.0e-02 | BCL3,CASP1,CXCL12,CXCL13,CXCR4,FLT3LG,HLA-A,ICAM1,IL1RN,MAP3K14,TLR4 | NA |
| chelerythrine | NA | chemical drug | Activated | 2.54e+00 | NA | 0.0e+00 | ATP6AP2,CASP3,Ccl2,CYBA,CYBB,ICAM1,NFKBIA,NOX1,SELE,VCAM1 | 1017 (13) |
| ZC3H12C | 8.80e-01 | other | Activated | 2.52e+00 | NA | 5.0e-02 | 9930111J21Rik1/Gm12185,CCR5,GBP2,GBP7,GPCPD1,GPR34,Kctd12b,PLA2G7,STAT1,TLR8 | NA |
| I-BET-151 | NA | chemical reagent | Activated | 2.52e+00 | NA | 1.0e-01 | CPNE2,DPP4,FOXP3,IL17A,MYCN,PRRT2,RAB27A,RIN3,SLC9A9,TIFAB,TRERF1 | NA |
| ABCB4 | NA | transporter | Activated | 2.52e+00 | bias | 0.0e+00 | ACTA2,BCL2L1,Ccl2,CCL21,CCR1,COL1A1,CXCL10,CXCL14,FN1,MAP2K4,MMP2,NOX4,NR5A2,NTRK2,PROM1,SERPINE1,SOCS3,SPARC,SPP1,TGFB1,TIMP1,VIM | 1330 (20) |
| HIVEP1 | 2.00e-02 | transcription regulator | Activated | 2.50e+00 | bias | 1.0e-02 | CARD11,FCER1G,IL1R1,IL1RN,IL33,IRAK2,MRAS,NFKBIA,NFKBIB,PRKCZ,TGFA,TLR4,TLR5,TLR8,TNFRSF1B,TRADD | NA |
| fingolimod | NA | chemical drug | Activated | 2.49e+00 | NA | 1.0e-02 | ADIPOQ,AXL,BCL2L1,BDNF,Ccl2,Ccl7,CD36,CD86,CDH1,CDH2,CDK2,CDKN1A,COL3A1,CXCL10,CXCL13,FN1,HLA-DQA1,ICAM1,MITF,RUNX2,SERPINE1,SPHK1,TGFB1 | 1456 (19) |
| miR-200b-3p (and other miRNAs w/seed AAUACUG) | NA | mature microRNA | Activated | 2.48e+00 | bias | 1.0e-02 | BAP1,CDH1,ERRFI1,JAG1,KCNK1,LSR,MSLN,PTPN12,PTPRD,RHPN2,RNF128,VIM,WDR37,ZEB2,ZFPM2 | NA |
| miR-21-5p (and other miRNAs w/seed AGCUUAU) | NA | mature microRNA | Activated | 2.48e+00 | bias | 1.0e-02 | ACTA2,BCL2L1,BTG2,C8orf44-SGK3/SGK3,CDK6,CDKN1A,CFL2,GFAP,JAG1,KDR,MITF,MMP2,PIK3R1,PRRG4,RECK,RP2,SESN1,SMAD7,SOCS1,TAGLN,TNFRSF11B | 1096 (17) |
| miR-186-5p (miRNAs w/seed AAAGAAU) | NA | mature microRNA | Activated | 2.47e+00 | bias | 1.0e-02 | CDH1,FGR,FOXO1,LTBP2,MYCN,NFAM1,TWIST1,VIM,ZFHX4 | NA |
| CBX5 | 1.60e-01 | transcription regulator | Activated | 2.46e+00 | bias | 2.0e-02 | AXIN2,BCL11A,C15orf48,CDKN1A,CEACAM1,CKM,CYP1B1,H2AC18/H2AC19,KIT,LEF1,MAL2,MAP1LC3A,MYOG,NNT,OLR1,PPARG,PROM2,QPCT,QPRT,RUNX2,SBSPON,SELENBP1,SLC2A10,SLC7A8,SNTB1,SYTL2,TGFBI,TICAM2,TM4SF1,TSPAN8,Zfp429 (includes others) | NA |
| MEOX2 | -1.89e+00 | transcription regulator | Activated | 2.46e+00 | NA | 2.0e-02 | CDKN1A,EDN1,F3,FGF2,ICAM1,ID4,ITGB3,MMP14,PTX3,SELE,VCAM1,VEGFC | NA |
| retroinverso ERG inhibitory peptide 2 | NA | chemical reagent | Activated | 2.45e+00 | bias | 0.0e+00 | ADAMTS1,ARHGDIB,CACNA1D,CXCR4,PLAT,TDRD1 | 778 (7) |
| retroinverso ERG inhibitory peptide 1 | NA | chemical reagent | Activated | 2.45e+00 | bias | 0.0e+00 | ADAMTS1,ARHGDIB,CACNA1D,CXCR4,PLAT,TDRD1 | 778 (7) |
| PROKR1 | 2.40e-01 | G-protein coupled receptor | Activated | 2.45e+00 | bias | 0.0e+00 | CDH1,SNAI1,SNAI2,STEAP1,TWIST1,VIM | 696 (7) |
| TPM3 | NA | other | Activated | 2.45e+00 | bias | 0.0e+00 | IGF1,ITGA1,ITGA3,MMP2,TEK,TNFRSF25 | NA |
| EEF1A2 | 8.70e-01 | translation regulator | Activated | 2.45e+00 | NA | 0.0e+00 | CYBA,CYBB,ITGAL,ITGB2,NCF1,NOX1 | NA |
| BBP-398 | NA | chemical drug | Activated | 2.45e+00 | bias | 1.0e-02 | CCND1,DUSP6,EGR1,ETV5,PHLDA1,SPRY4 | 483 (7) |
| JTE-013 | NA | chemical reagent | Activated | 2.45e+00 | NA | 2.0e-02 | BTRC,F3,FN1,ICAM1,SELE,VCAM1 | NA |
| progestin | NA | chemical drug | Activated | 2.45e+00 | NA | 1.7e-01 | CCDC96,CCND1,FOXO1,NFKBIA,PDK4,TADA2B,VEGFD | NA |
| YTHDF2 | 2.40e-01 | other | Activated | 2.44e+00 | bias | 1.0e-02 | ABCA1,ABCG1,KLF4,PDGFC,SMAD6,TNFRSF1B | NA |
| SU1498 | NA | chemical drug | Activated | 2.43e+00 | bias | 0.0e+00 | ANGPT2,ETS1,ICAM1,SELE,TNFRSF11B,VCAM1 | 1087 (15) |
| PECAM1 | NA | other | Activated | 2.43e+00 | NA | 0.0e+00 | BCL2L1,CCND1,CD36,CD44,MMP2,SELP,THBS1 | 974 (18) |
| (Z,E)-5-(4-ethylbenzylidine)-2-thioxothiazolidin-4-one | NA | chemical reagent | Activated | 2.43e+00 | NA | 1.0e-02 | CDH2,COL1A1,CTNNAL1,EZH2,GLI1,HSP90AA1,SNAI1 | 1125 (7) |
| EED | -1.50e-01 | transcription regulator | Activated | 2.43e+00 | bias | 1.0e-02 | BDNF,DAB2IP,GATA4,GFAP,KLF4,MMP2,NKD1,PAX3,PPP2R2B,PTGS2,RUNX2,TBX3,TBX5,THY1 | 1532 (24) |
| GLUL | 1.38e+00 | enzyme | Activated | 2.43e+00 | NA | 3.0e-02 | CAV1,CXCR4,GLUL,MRC1,MSR1,SLC1A5 | NA |
| KLK1 | 6.90e-01 | peptidase | Activated | 2.43e+00 | NA | 3.0e-02 | ARG1,Ccl2,CYBB,NCF1,NCF2,TGFB1 | NA |
| SRT1720 | NA | chemical drug | Activated | 2.43e+00 | NA | 4.0e-02 | FN1,HAS2,HIF1A,TNFAIP6,VCAM1,VIM | NA |
| DNAJB6 | 2.80e-01 | transcription regulator | Activated | 2.43e+00 | NA | 5.0e-02 | CDH2,SNAI2,SPARC,SPP1,TWIST1,VIM | NA |
| thiostrepton | NA | chemical - endogenous non-mammalian | Activated | 2.43e+00 | NA | 8.0e-02 | CCND1,GADD45A,NCAPG,SKP2,TLR7,TLR8 | NA |
| acetylcholine | NA | chemical - endogenous mammalian | Activated | 2.43e+00 | NA | 1.7e-01 | CAMK2A,GNAI3,HRAS,KCNQ2,PNMT,RELN,SELE,SOCS3,TNFRSF11B | NA |
| atorvastatin | NA | chemical drug | Activated | 2.43e+00 | NA | 0.0e+00 | ABCA1,ABCC3,ABCG1,ADIPOQ,BCL2L1,BDNF,CASP3,CAV1,CCBE1,Ccl2,CCNE2,CD36,COL1A1,CRP,CXCR4,CYBA,CYBB,CYP27A1,DHCR7,DUSP1,EDN1,EGR1,ENG,ENPP3,F2R,F3,GADD45B,GJC1,GLI1,GLI2,GPAM,GSR,HBA1/HBA2,HYPK,ICAM1,IER3,IL17RD,IL2RA,ITGAL,ITGB2,LIPG,LPL,LRRK1,LSS,MAP1LC3A,MAPK3,MMP2,MSMO1,MVD,MVK,MYOCD,NOS1,NOX1,NOX4,NR0B2,NR4A1,OLR1,PLAT,PNPT1,PPARG,PRELID3A,PTGS2,RHOA,S100B,SELE,SELP,SERPINE1,SLC25A51,SLCO2B1,SPP1,TGFB1,TLR2,TLR4,TMEM17,USP49,VCAM1,ZFP36,ZNF652 | 1413 (17) |
| huaier extract granule | NA | chemical drug | Activated | 2.43e+00 | NA | 1.0e-02 | CAV1,CCND1,DIXDC1,FN1,KIT,WNT5A | 1231 (9) |
| 101.10 peptide | NA | chemical reagent | Activated | 2.43e+00 | bias | 4.0e-02 | Ccl2,CRP,IL1RN,OXTR,PTGFR,PTGS2 | NA |
| wortmannin | NA | chemical drug | Activated | 2.43e+00 | NA | 0.0e+00 | ACTA2,ANPEP,ATF3,BCL2L1,BCL2L11,BDNF,CASP3,Ccl2,CCND1,CCND2,CCR3,CD36,CD44,CDH1,CDK2,CDKN1A,CEBPD,COL1A1,COL3A1,CREB1,CRP,CSF1,CX3CL1,CXCL10,CXCL16,E2F2,EGR1,ENTPD1,ERBB3,EZR,F2R,F3,FAM3B,FN1,FOXC2,GAP43,GCLC,GPD1,HAS2,HIF1A,ICAM1,IGF1,IL17A,IL2RA,IRF1,IRF8,IRS1,IRS2,MAF,MAP1LC3B,MMP14,MMP2,MSN,MSR1,NFE2L2,NFKBIA,NR4A1,NR4A3,OGT,PPARD,PTGS2,RETN,RHOA,SAMSN1,SELE,SELP,SERPINE1,SLC1A1,SNAI1,SOCS3,SREBF1,TP63,VCAM1,VIM | 1149 (14) |
| RUNX3 | -9.00e-02 | transcription regulator | Activated | 2.43e+00 | NA | 0.0e+00 | ABCC5,BCL2L11,CCND1,CDH11,CDKN1A,CHST3,CIITA,COL12A1,CSF1R,EXT1,EXTL3,FBN1,FGF2,FGF9,FLNA,FOXP3,FSTL1,FZD2,GLI2,GRK5,IL17A,ITGAE,ITGAL,JAG1,KCTD15,KHDRBS3,LILRB3,LOX,MID1,MMP2,NUAK1,PCDH7,PXDN,RHOBTB1,RNF150,RUNX1,SCARA3,SGPP1,SNAI2,SPP1,SPRED1,SVEP1,TGFB1,THY1,UGCG,VIM,VWF | 1299 (22) |
| Tcf7 | 1.08e+00 | transcription regulator | Activated | 2.42e+00 | NA | 0.0e+00 | ANXA1,ARHGDIB,BACH1,BATF,BCL11B,Ccl6,CD101,CD200,CD83,CDH1,CDKN1A,CEBPD,CISH,CX3CR1,CXCR5,DEPDC1B,DNASE1L3,DTX1,ECM1,EGR2,EGR3,ELK3,EMILIN2,ENO2,EPHX1,EZH2,FAAH,FGFR1,FYN,G0S2,GCNT2,GM2A,GPD2,Gprasp2,GSAP,HIF1A,HLA-DQA1,ID2,IFITM3,IL15RA,IL17A,IL1R1,IL2RA,IL2RB,IL34,INPP5D,INPP5F,IRAK3,IRF4,JAM2,KIF11,KIT,KLF6,LAMA3,LEF1,LONRF1,LPCAT2,LYN,MAF,MBOAT1,METRNL,MSMO1,MVD,Naip1 (includes others),NCF1,NCOA7,NR2F2,NR5A2,NTN4,OSBPL3,P2RY1,PCSK1N,PDGFB,PENK,PHLDA1,PKIB,PLA2G7,PLTP,Pmaip1,PPARG,PRDM1,PRDX4,PTPRO,PYGL,RARG,RASGEF1B,REL,RUNX2,S100A4,SDC1,SH3BGRL2,SLC35D1,SLC41A2,SOAT1,SOCS3,SPECC1,ST14,STAT1,STX11,SYTL2,TGFB1,TMEM176A,TNFRSF19,TOX,TRPM1,WDFY4,ZC3H12D | 1652 (20) |
| N’-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide | NA | chemical reagent | Activated | 2.42e+00 | NA | 3.0e-02 | CCND2,CISH,IER3,IRF5,PRDM1,SDC1 | NA |
| phenyl-N-tert-butylnitrone | NA | chemical reagent | Activated | 2.42e+00 | NA | 5.0e-02 | CD83,CD86,FN1,HSPA1A/HSPA1B,PTGS2,TGFB1 | NA |
| PKP2 | -2.20e-01 | other | Activated | 2.42e+00 | NA | 0.0e+00 | Ccl2,COL2A1,COL3A1,FN1,PPARG,TGFB1 | 1418 (13) |
| mir-218 | NA | microRNA | Activated | 2.42e+00 | NA | 1.0e-02 | CDH1,CDH2,FZD4,LEF1,LOXL4,MITF,PDGFRA,VAV3,ZEB2 | 1085 (7) |
| acyclic retinoid | NA | chemical drug | Activated | 2.42e+00 | NA | 2.0e-02 | CCND1,CDKN1A,KDR,MYCN,PDGFRA,TEK,XPO1 | NA |
| decursin | NA | chemical - endogenous non-mammalian | Activated | 2.41e+00 | NA | 5.0e-02 | ANGPT2,CCND1,CDK2,CDK6,CDKN1A,KDR | NA |
| mir-326 | NA | microRNA | Activated | 2.41e+00 | NA | 0.0e+00 | CD47,ETS1,FSCN1,GLI1,NOTCH2,SMO | NA |
| miR-182-5p (and other miRNAs w/seed UUGGCAA) | NA | mature microRNA | Activated | 2.41e+00 | bias | 0.0e+00 | CARD11,CDH1,CDK6,FN1,FOXO1,FOXO3,GADD45G,GJA3,HERC6,IFI44L,IFIT1,INHBC,ISG15,ITGA4,MITF,MTSS1,NCAM1,NMI,RARG,RPS6KB1,RSAD2,RTP4,SP110,STAT1,VWF | NA |
| L-histidine | NA | chemical - endogenous mammalian | Activated | 2.41e+00 | NA | 1.0e-02 | ASNS,ATF3,DDIT4,EGR1,ELAVL1,SLC38A2 | 1421 (19) |
| UXT | 2.60e-01 | transcription regulator | Activated | 2.40e+00 | NA | 0.0e+00 | B4GALT1,BUB1,CCNA2,ENO2,F5,FKBP5,HUS1,IL2RA,KDELR3,NFKBIA,PMEPA1,SEC24D,SORD | 1149 (7) |
| SMURF1 | -4.00e-02 | enzyme | Activated | 2.40e+00 | NA | 1.0e-01 | CXCL10,IRF1,NR4A1,RUNX2,SMAD6,SREBF1 | NA |
| MIR124 | NA | group | Activated | 2.40e+00 | NA | 5.0e-02 | CAV1,CDK6,GRIA2,IQGAP1,JAG1,PTPRC,ROCK1,SNAI2,SPHK1,VIM | NA |
| sirolimus | NA | chemical drug | Activated | 2.40e+00 | NA | 0.0e+00 | ABHD11,ACTA2,ANXA5,ARF1,ARG1,ARHGDIB,ASNS,ATP1A1,ATP2B4,ATP6AP2,ATP6V0B,ATP6V1A,B2M,BCKDHA,BCL2A1,BCL2L1,BCL2L11,BCL3,C3,C5AR1,CACNA1D,CASP3,Ccl2,CCNA2,CCND1,CCND2,CCR5,CD36,CD86,CDK6,CDKN1A,CFB,CLIC1,COL1A1,COX6B1,CSF1,CTSK,CX3CR1,CXCR4,DAD1,DDIT4,DPYSL2,EEF1A1,EGR1,EGR2,ENTPD1,ERBB3,ERCC1,F3,FGF2,FGF9,FN1,FOXO3,FOXP3,FSCN1,G6PD,GAP43,GCLC,GPD1,HGF,HIF1A,HNRNPU,HSP90AA1,ICAM1,ID2,IDH1,IGF1,IGFBP5,IL16,IL17A,IL2RA,IL33,IL7,IRS1,IRS2,ISG15,KDR,LDHB,LEPR,LGR5,LPIN1,MAF,MAP1LC3A,MAP1LC3B,mir-143,MKI67,MMP14,MMP2,MPZ,MRC1,Mt1,MTHFD2,MYBPC3,MYH6,MYH7,MYL2,MYOG,NCAM1,NEU1,NLRP3,NR4A3,NTS,OAZ1,OCLN,PARP14,PDGFB,PDGFRA,PGAM2,PGK1,PGM1,PIK3R1,PKM,PLIN1,PPARD,PPARG,PPIA,PRDX5,PROM1,PSMA4,PSMA6,PSMB1,PTX3,RCAN2,RHOA,RPL18,RPL23,RPL35,RPL37A,RPL6,RPS10,RPS15,RPS16,RPS18,RPS2,RPS24,RPS3,RPS6KB1,RUNX2,S100A4,SERPINE1,SLC1A5,SLC25A38,SLC25A43,SLC27A1,SLC2A1,SLC35C2,SLC38A3,SLC39A6,SLC41A2,SLC6A9,SNAI1,SOCS3,SREBF1,SRSF3,STAT1,STMN1,STX4,TGFB1,THBD,TIMP1,TNFRSF11B,TOP2A,TYMS,VCAM1,VEGFD,VIM,ZFP36 | 1707 (18) |
| HNRNPK | 1.70e-01 | other | Activated | 2.39e+00 | NA | 0.0e+00 | ALOX15,CDKN1A,COL12A1,FOXP3,G6PD,HUS1,IGSF10,IL2RG,ITGA6,LPIN1,NFE2L2,NRXN2,PPARG,PRELP,PTGS2,SLC47A1,SPN,VCAN,ZBTB20 | 1050 (7) |
| DMD | NA | other | Activated | 2.39e+00 | NA | 0.0e+00 | ACTG1,Actn3,AMPD1,ANKRD1,AQP4,ATP1B2,ATP2A1,BGN,BTG2,CDKN1A,CFL2,CNKSR1,COL23A1,COL3A1,CSRP3,CTSS,DNAJC5,EEF1A1,EGF,EPB41L4B,FBXO32,GATM,GJA5,GPD1,GRHL1,HSPB6,HTR2B,IGF1,IGFN1,IP6K3,KCNC1,KCNK3,LAMP2,LPIN1,MALL,MAOB,MAP7,MSI2,MSTN,MYBPC1,MYBPC2,MYBPC3,MYH2,MYH7,MYH8,MYL1,MYLK2,MYOD1,MYOM2,MYOZ1,NOS1,OBSCN,PAMR1,PDK4,PHKG1,PKM,PLA2G4E,PLPP3,PPP1R3C,PROX1,PSTPIP2,PTGFRN,PVALB,PYGM,RCSD1,S100A10,SCN1B,SCN3B,SELENOP,SGCA,SLC46A3,SORT1,SPTB,ST3GAL6,STARD10,SUSD4,TNNI1,TTL,TTLL7,TUBA8,UTRN,VIM,XK | 835 (7) |
| PCI-34051 | NA | chemical reagent | Activated | 2.39e+00 | NA | 0.0e+00 | ACTA2,COL1A1,FN1,MMP2,SNAI1,VIM | 1330 (20) |
| miR-126a-5p (and other miRNAs w/seed AUUAUUA) | NA | mature microRNA | Activated | 2.39e+00 | bias | 2.0e-02 | DLK1,KIT,MITF,SLC45A3,SNAI2,TWIST1 | NA |
| NCOR1 | 5.00e-02 | transcription regulator | Activated | 2.39e+00 | NA | 0.0e+00 | ADIPOQ,BCL3,CCNA2,CCND1,CDH1,CDKN1A,CREM,CSF3R,CXCL10,DIO1,DUSP1,HAS2,HK1,ISG15,MB,MRPS18B,MYOD1,MYOG,NCOR2,NDUFV1,OAS3,Oasl2,PDK4,PFKFB1,PLA2G2A,PLIN1,PPARG,PRDM1,PTGS2,RARA,SERPINF1,SLC25A45,SREBF1,UCP3,ZFP90 | 1344 (24) |
| SOCS3 | -1.49e+00 | phosphatase | Activated | 2.39e+00 | NA | 0.0e+00 | ABCA1,ACTA1,ARG1,ATF3,Ccl2,CCND1,CD86,CDKN1A,CXCL10,EGR1,F3,FCGR1A,FOXP3,ICAM1,IFIT1,IGFALS,IL17A,IL1RN,IRF1,IRF8,IRS1,IRS2,MX1,OASL,SELP,SGCA,SOCS1,SOCS3,SREBF1,STAT6,TGFB1,TNFRSF1B | 1187 (16) |
| miR-7a-5p (and other miRNAs w/seed GGAAGAC) | NA | mature microRNA | Activated | 2.38e+00 | bias | 2.0e-02 | IRS1,IRS2,KLF4,KMT5A,OGT,SNAI1,SNAI2,SNCA,TWIST1,VIM | NA |
| Ro41-5253 | NA | chemical reagent | Activated | 2.37e+00 | NA | 0.0e+00 | APOD,CDKN1A,CSF1R,F3,IRF1,PLAT,PPARG,RARA,RARG,SMPD3,THBD | 1095 (19) |
| CUL3 | 5.20e-01 | enzyme | Activated | 2.37e+00 | NA | 0.0e+00 | ACADL,Actn3,BTBD1,CCND1,CD22,COL2A1,DBP,FBXO32,IRS1,MYBPC2,MYH7,MYL2,MYL3,NFE2L2,NT5C1A,NUDT4,OGT,PLS3,SPON1,TAGLN,TCEA3,UCP3 | 1138 (17) |
| NR0B2 | -8.80e-01 | ligand-dependent nuclear receptor | Activated | 2.36e+00 | NA | 0.0e+00 | ABCA1,ABCC3,ARG1,CARD11,Ccl2,CD36,CD86,CDKN1A,COL1A1,CXCL10,CYP7B1,EGR1,ESRRG,FABP1,FGFR1,HDC,IL1RN,IL33,ISG15,LPIN1,NR0B2,PDIA4,PDK4,PIK3C2G,PIK3CG,PLCG2,PPARG,SERPINE1,SPP1,SREBF1,TGFB1,TIMP1,TLR2,TLR8 | 1360 (22) |
| NF1 | -4.00e-01 | other | Activated | 2.36e+00 | NA | 0.0e+00 | AXIN2,BCL2L1,CCND1,FGF2,GLI1,ICAM1,KCNC1,MAF,MDK,MPZ,MYH7,PDGFB,PVALB,SELP | 1374 (18) |
| FUT8 | -2.00e-01 | enzyme | Activated | 2.36e+00 | NA | 2.0e-02 | CYP1B1,ELN,FZD6,GOLM1,HCCS,MGAT3,NFE2L2,PROM1,SMAD7 | NA |
| curcumin | NA | chemical drug | Activated | 2.35e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACTA2,ADAM17,ADAMTS5,ADIPOQ,ALOX5,AQP4,ATOX1,ATP1B2,ATP6AP2,AXL,BCL2L1,BCL2L11,BDNF,BIRC3,CASP3,CAV1,Ccl2,CCND1,CCND2,CD36,CD44,CD86,CDC14B,CDH1,CDK2,CDK6,CDKN1A,CLIC1,COL1A1,CRP,CXCR4,DAPK1,DNAJB1,EDN1,EGR1,ELAVL1,ETS1,EZH2,F3,FGF2,FGFR1,FTL,FYN,GFAP,GLUL,GSR,HGF,HIF1A,HSPA1A/HSPA1B,ICAM1,IGFBP4,IGFBP5,IKBKB,IL10RB,IL17A,IRS1,ITGA6,ITGB4,JUND,KLF9,LPL,MAP2,MAPK3,MARCKSL1,MMP14,MMP2,NCAM1,NFE2L2,NFKBIA,NOTCH2,OCLN,OLR1,PDE3B,PNPLA2,PPARG,PPP1R3A,PRPS2,PTGES,PTGIS,PTGS2,PTN,RETN,RUNX2,SELE,SERPINE1,SLC37A4,SMAD7,SNAI1,SOCS1,SOCS3,SREBF1,TACC2,TESK1,TLR2,TLR4,TNFRSF10A,TOP2A,UBA7,VCAM1,VIM,WEE1,WNT10B,XYLT1 | 1505 (18) |
| vitamin E | NA | chemical drug | Activated | 2.35e+00 | NA | 0.0e+00 | ACTA1,ACTA2,ALOX12,BCL2L1,Casp12,CAV1,CD36,CD44,CD53,CDH1,CDKN1A,COL2A1,EGR1,F3,KLF6,LPL,MMP14,MMP2,NFIL3,NOS1,PLAT,PTGS2,PVALB,SELP,SERPINE1,SPP1,TGFB1,VCAM1 | 1021 (15) |
| miR-145-5p (and other miRNAs w/seed UCCAGUU) | NA | mature microRNA | Activated | 2.35e+00 | bias | 0.0e+00 | ABRACL,ACTA2,ACTG2,AXL,CBFB,CCNA2,DDR1,FBXO28,FLI1,FSCN1,IRS1,KLF4,KLF5,LAMP2,MITF,MYO5A,MYOCD,NR5A1,PLA2G4A,PPP3CA,PROM1,RAB27A,SERPINE1,SOX10,SPTB,STAR,SWAP70,TAGLN,USP46,VASN | 1601 (19) |
| DMP1 | 9.00e-01 | other | Activated | 2.35e+00 | NA | 1.0e-02 | ADD3,CORO2B,CX3CR1,E2F5,F13A1,Fcrls,FGF1,LIPG,RUNX2,S100B,SLC6A9,SMAD6,SOX10,SPP1 | NA |
| ALDH2 | 5.60e-01 | enzyme | Activated | 2.35e+00 | NA | 1.2e-01 | ACTA2,COL1A1,FN1,GCLC,Gsta4,MTHFD2,PHGDH,SHMT1,SLC1A4 | NA |
| SERPINE2 | -3.10e-01 | other | Activated | 2.33e+00 | NA | 5.0e-02 | BDNF,Ccl2,CCL21,CD34,CXCL10,CXCL13,GLI1,IL17A,ITGB2,PTCH1,SELE | NA |
| CD276 | -6.60e-01 | other | Activated | 2.33e+00 | NA | 4.0e-02 | CD86,CXCL10,IFIT1,IRF1,MX1,MYOG,OAS3,SOCS1,STAT1 | NA |
| celecoxib | NA | chemical drug | Activated | 2.33e+00 | NA | 0.0e+00 | ALOX5,BCL2A1,BCL2L1,CASP3,CCND1,CDH1,CDKN1A,CENPF,COL3A1,CRP,CTSK,F3,GADD45A,HIF1A,HUS1,ICAM1,IL7,KDR,MAGI1,MET,MKI67,MMP2,PPARD,PPARG,PTGS2,RIPK2,SELP,SERPINE1,SLC25A6,TLR2,TLR4,TNFRSF10A,TNFRSF1B,TP63,VCAM1,VEGFC,WNT5A | 1189 (14) |
| 15-deoxy-delta-12,14 -PGJ 2 | NA | chemical - endogenous mammalian | Activated | 2.32e+00 | NA | 0.0e+00 | ACTA2,ACTC1,BCL2L1,BIRC3,CASP3,CAV2,Ccl2,CCND1,CCND2,CD200,CD36,CDK2,CDKN1A,CEBPD,CIITA,COL1A1,CSPG4,CXCL10,CXCL13,CYBB,DNAJB1,E2F2,EGR1,FN1,GADD45A,GCLC,GFAP,GSR,HGF,HLA-DRA,HTRA3,ICAM1,IRF1,KDR,KIT,KLF4,MAP1LC3B,MAPK14,MSR1,MYF5,MYOD1,MYOG,NFE2L2,NFKBIA,NFKBIB,NOX1,NOX4,NR5A2,PDGFRA,PLA2G4A,Podxl,PPARG,PRDX1,PTGES,PTGS2,REL,RUNX2,SELE,SERPINE1,SFRP2,SFTPB,SLC9A1,SOAT1,SOCS1,SOCS3,SPP1,SREBF1,STAT1,TBXAS1,TFCP2L1,TMPRSS2,VCAM1 | 1165 (16) |
| BAPTA-AM | NA | chemical reagent | Activated | 2.32e+00 | NA | 0.0e+00 | ATF3,BDNF,CDH1,CDKN1A,CISH,COL1A1,CXCL10,EGR1,FAM3B,FN1,ICAM1,IL1R1,MMP2,NR4A1,PTGS2,S100B,SELE,SOCS1,SOCS3,TRPC3,VCAM1 | 1113 (16) |
| R-WIN 55,212 | NA | chemical reagent | Activated | 2.31e+00 | NA | 5.0e-02 | CASP3,CCND1,CCND2,CDK2,CDK6,E2F2,ICAM1,TFDP2,VCAM1 | NA |
| NPR1 | -8.40e-01 | enzyme | Activated | 2.29e+00 | NA | 0.0e+00 | ABCC8,ACTA1,COL1A1,COL3A1,FN1,KCNJ11,MMP2,MYH7,NFATC3,RGS4,SLC9A1,TGFB1 | 1348 (17) |
| cycloheximide | NA | chemical reagent | Activated | 2.29e+00 | NA | 0.0e+00 | ACTC1,AHR,Akr1b7,ALDOA,APBB1IP,AQP4,ATP2B4,B2M,BCL2L1,BDNF,BIRC3,BMP1,BTG2,BTK,CAMK2A,CAV1,CCND1,CCR1,CD44,CDKN1A,CEBPD,CITED2,CKM,COL1A1,COL2A1,COL5A1,CSF1,CXCL10,CXCR4,DDIT4,DIO1,DUSP1,EDN1,EEF1A1,EEF1D,EGR1,FABP1,FGF2,FGFR1,FN1,GADD45A,GADD45B,GADD45G,GAP43,GAS7,GCLC,GNAI1,GNAI3,GNAS,HGF,HIF1A,ICAM1,IFIT1,IGF1,IGFBP4,IGFBP5,IGFBP6,IL1RL1,IL1RN,IRS2,ITGB3,JUND,KLF3,KLF5,LPL,MC2R,MLKL,MME,MMP19,MMP2,Mt1,MYCN,MYOG,NFE2L2,NFKBIA,NR4A1,OGN,OLR1,PDGFB,PDGFRA,PEX5,PFKFB3,PGK1,PLA2G2A,PLAT,PLK1,PNMT,PPARG,PRDM1,PRKAR2B,PTGIS,PTGS2,PTX3,RARG,RERG,RGS2,RSAD2,RUNX2,RXRA,SELE,SELP,SERPINE1,SIRT2,SIRT7,SLC12A4,SLC2A1,SOCS3,SPP1,STAR,TGFA,TGFB1,THBD,THBS1,TIMP1,TNFAIP2,TNFAIP6,TNFRSF10A,TNFRSF11B,TRA2A,TSHR,TYMS,UACA,VCAM1 | 1167 (14) |
| PAX5 | -2.00e-02 | transcription regulator | Activated | 2.27e+00 | NA | 1.0e-02 | BCL2L1,BTK,C8orf44-SGK3/SGK3,CCND1,CD22,CIITA,CSF1R,CSF2RA,FN1,G6PD,GRHL1,MET,MMP2,MSN,PRDM1,PTPRF,PYGL,SDC1,SLC2A1,VIM | 1336 (18) |
| naringenin | NA | chemical - endogenous non-mammalian | Activated | 2.27e+00 | NA | 1.0e-02 | ACTA2,BDNF,CDH2,COL1A1,COL3A1,CXCL10,LYN,MMP2,PTGS2,SREBF1,TGFB1,TLR2,TLR4,VIM | 1303 (23) |
| CDKN1B | -5.00e-01 | kinase | Activated | 2.27e+00 | NA | 1.0e-02 | ADGRE5,APCDD1,B2M,BCL11A,BTK,CCND1,CDH1,CDK2,CDKN1A,CYTH1,DHH,EGR1,FHL1,FLT3LG,GAP43,IL2RA,LEF1,MCM7,MYOD1,PALD1,PES1,RDH5,RRAD,RUNX1,SELENOP,SERPINE1,SHMT1,SKP2,SLC9A1,SMAD7,TEKT1,TWIST1 | NA |
| NPC2 | 3.60e-01 | transporter | Activated | 2.26e+00 | NA | 0.0e+00 | Ccl2,COX4I1,Cox8b,CREB5,MAP1LC3A,MAP1LC3B,PLA2G4A,PPARG,PTGES,PTGS2,STAT1,TLR4 | 1248 (19) |
| SIRT1 | -1.70e-01 | transcription regulator | Activated | 2.26e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACADL,ACD,ADAMTS5,ADIPOQ,ANO1,APLN,ARG1,ARNT2,BCL2L1,BDNF,BIRC3,BTRC,CA12,CAV1,Ccl2,CCND1,CCND2,CD36,CD74,CD83,CD9,CDH1,CDH2,CDKN1A,CDKN2C,CNR1,COL2A1,CORO1A,COX4I1,CREB1,DBP,DDAH2,DHX58,EDEM1,EIF2AK3,ERMP1,Esrra,FBXO32,FBXO39,FCMR,FGF10,FGFR1,FLT3LG,FN1,FOXC2,FOXO1,FOXO3,FOXP3,GABARAPL1,GADD45A,GATA4,GLI1,HCK,HGF,HIF1A,HIVEP3,HLA-A,HLA-DQA1,HOXA5,ICAM1,IFI44,Ifi47,IFITM3,IGF1,IL17A,IL2RG,KCNA1,KDM2B,KIF1A,KIF5C,LAMA2,LAMA4,LEF1,LTBP2,MADD,MAF,MAT2A,MGAT2,MLLT1,MMP2,MVK,MYOG,NCF1,NEDD4L,NEURL1,NFE2L2,NTRK2,Oasl2,PANK3,PARP14,PC,PDGFRA,PDK4,PER1,PHKB,Pmaip1,PNPLA3,PRDM16,PRKCI,PTN,PYGM,RBPJL,RIMS2,RNF213,ROCK1,RSAD2,RTP4,RUNX2,Scd2,SCX,SERPINE1,SFRP2,SFRP4,SFRP5,SLC27A6,SLC2A1,SLC36A2,SLC7A10,Slfn2,SOCS3,SP110,SREBF1,SSBP3,STAT1,TAL1,TBC1D10C,TBC1D8,THBD,Tpi1 (includes others),TRIM63,UBA7,USP18,VCAM1,VEGFD,VIM,WNT2 | 1527 (18) |
| INSIG1 | 5.00e-02 | other | Activated | 2.25e+00 | NA | 0.0e+00 | AACS,ABCA1,ABCG1,ATF3,CCR5,CXCL10,CXCL13,CXCR4,CYP4F2,DHCR7,DLK1,ELOVL1,FADS1,FADS2,G6PD,GPAM,HLA-DQA1,IRF8,IRS2,LIPG,LPIN1,LPL,LSS,MRC1,MVK,NFE2L2,OLR1,PLA2G7,PLD1,PPARG,PTGES,RAB27A,Scd2,SREBF1,STEAP2,TGFB1 | 1048 (12) |
| caffeic acid phenethyl ester | NA | chemical drug | Activated | 2.25e+00 | NA | 0.0e+00 | BCL2L1,BIRC3,CASP3,Ccl2,CCND1,CD44,CD83,CDK2,CDKN1A,CXCL10,EGR1,ELOVL1,ERCC1,F3,FCGRT,FTL,GSR,ICAM1,IGFBP6,KLF6,MKI67,MMP14,MMP2,NFE2L2,NFKBIA,NFKBIB,OLR1,PLD1,PTGFR,PTGS2,RARA,RXRA,S100A6,TGFB1,TLR2,TWIST2,VCAM1,VIM | 1130 (14) |
| Rhox5 | 1.06e+00 | transcription regulator | Activated | 2.24e+00 | NA | 0.0e+00 | ADIPOQ,BPGM,CA3,FZD2,IDH3A,JAZF1,KLF9,PLTP,PPARG,RETN,TMEM176A,TMEM176B,UNC5C | 1151 (7) |
| CAT | -5.80e-01 | enzyme | Activated | 2.24e+00 | NA | 0.0e+00 | AIF1,BCL2A1,BDNF,CAV1,Ccl2,CD36,CDKN1A,COL1A1,CYP1B1,FN1,GCLC,GFAP,HIF1A,HLA-DRA,IL2RA,PTGS2,SERPINE1,TAGLN,THBS1,TIMP1,TNC,VCAM1,VIM | 1337 (16) |
| RANBP3L | -1.13e+00 | other | Activated | 2.24e+00 | NA | 0.0e+00 | BGN,CCDC91,EIF5A2,ENOX2,GLIPR2,HOXD10,HOXD9,INHBA,ITGB7,LRRC61,NRK,PARM1,PDLIM1,PMP22,SIGLEC10,SIM1,SMOC1,SPARC,SYT17,UNC5B | NA |
| miR-541-5p (and other miRNAs w/seed AAGGAUU) | NA | mature microRNA | Activated | 2.24e+00 | bias | 0.0e+00 | CCND1,CDH1,CDH2,MMP2,VIM | NA |
| 5’-methylthioadenosine | NA | chemical - endogenous mammalian | Activated | 2.24e+00 | NA | 2.0e-02 | ADIPOQ,CCND1,COL1A1,FGF2,MAT2A,PTGS2 | NA |
| thermozymocidin | NA | chemical reagent | Activated | 2.24e+00 | NA | 2.0e-02 | ADGRE1,BCL2L1,CD86,MRC1,NLRP3,PYCARD | NA |
| PRDM8 | 1.60e-01 | transcription regulator | Activated | 2.24e+00 | bias | 4.0e-02 | ANTXR2,BHLHE22,CDH11,GRIN3A,NRP2 | NA |
| SPTLC2 | -3.10e-01 | enzyme | Activated | 2.24e+00 | NA | 9.0e-02 | COL1A1,EIF2AK3,MMP2,THBS1,TIMP1 | NA |
| ENPP2 | 1.80e-01 | enzyme | Activated | 2.24e+00 | NA | 9.0e-02 | ADIPOQ,PPARG,PPARGC1B,PRDM16,SLC2A1 | NA |
| Sod | NA | group | Activated | 2.24e+00 | NA | 1.4e-01 | Ccl2,HLA-DRA,ICAM1,MMP2,VCAM1 | NA |
| fucoidin | NA | chemical drug | Activated | 2.24e+00 | NA | 5.8e-01 | CASP3,CDKN1A,CLDN1,CXCL12,ISG15 | NA |
| GFER | 7.40e-01 | enzyme | Activated | 2.24e+00 | NA | 1.0e+00 | COX4I1,NDUFB9,NDUFV1,NDUFV2,UQCR10 | NA |
| SCGB1A1 | 6.00e-01 | cytokine | Activated | 2.23e+00 | NA | 8.0e-02 | C3,Ccl2,CDKN1A,FN1,ITGB2,MMP14,MMP2,PTGS2 | NA |
| minocycline | NA | chemical drug | Activated | 2.23e+00 | NA | 0.0e+00 | ADGRE1,ALOX5,ATF3,BCL2L1,BDNF,CASP1,CASP3,CASP8,Ccl2,CD86,CYBB,GFAP,ICAM1,IL17A,MMP2,NOS1,PDGFB,PTGS2,RGMA,SLC16A1,TLR4,TNFRSF1B,VCAM1 | 1053 (15) |
| RB1 | -3.00e-02 | transcription regulator | Activated | 2.23e+00 | NA | 0.0e+00 | ACO2,ACTC1,ACTN2,Actn3,ADAM10,ANGPT2,ATF3,ATP1A1,ATP1B1,ATP6V1F,BARD1,BCKDHA,BCL2L11,BTG3,CALCRL,CASP3,CASP8,CCNA2,CCND1,CCNE2,CD44,CD83,CDCA4,CDCA7L,CDH1,CDK2,CDK5R1,CDKN1A,CELSR1,CELSR3,CENPK,CHRNA1,CITED2,CKM,CLDN3,CLIC4,CNOT6L,COL5A1,COQ7,COX14,COX4I1,COX6B1,CWC27,CYSLTR1,DEK,DLK1,DMPK,DONSON,DUSP1,E2F2,E2F5,E2F7,EGR1,EGR3,EHD3,Esrra,EZH2,EZR,F3,FAM111A,FANCA,FEN1,FGF2,FN1,FOXC2,FZD6,GADD45A,GADD45B,GADD45GIP1,GHITM,GLI2,GNAI1,GPR157,GPR160,GPR176,GPRC5C,GPT2,HACD3,HIF1A,HOMER1,HRAS,ID2,IFITM3,IGF1,IL16,IRS2,KCNK1,KDR,KIT,KLF10,LACTB,LGR5,LOXL2,LRAT,MAF,MAPK3,MAPK4,MCM7,MCM8,MDH1,MET,MMP2,MRPL53,MRPL58,MRPS23,MSN,MYBPC1,MYH2,MYH6,MYH7,MYH8,MYL1,MYOM2,NDUFS7,NDUFV1,NFKBIA,NR4A2,NR4A3,OAZ2,OGT,OLR1,OSMR,PARK7,PBX3,PER1,PGAM2,PGRMC1,PLK1,PMEPA1,PPARG,PPARGC1B,PROM1,PTPN4,PTX3,RAB27A,RANBP1,RBL1,RPS6KB1,RYR1,SAFB,SCTR,SERPINE1,SKP2,SLC26A7,SNTB2,SOX7,STK3,TGFB1,TIMM50,TNFRSF1B,TNNC1,TNNC2,TNNI2,TNNT1,TNNT2,TOB2,TOMM6,TOMM7,TP63,Tpm1,TPO,TUBA1A,TYMS,ZEB2,ZFP36,ZNF638 | 1513 (21) |
| siponimod | NA | chemical drug | Activated | 2.23e+00 | bias | 0.0e+00 | ACER2,APBB1IP,BCL2L11,CD86,CHI3L1,CIART,FAM78A,GPR34,HVCN1,IRF8,LEF1,MPP7,NCF1,NCKAP1L,PRKCD,PTPRC,SLC37A2,Tlr13,TNNT1 | NA |
| SPRY4 | -1.02e+00 | other | Activated | 2.22e+00 | bias | 0.0e+00 | CNN1,ETV5,ISG15,MYOCD,TAGLN | NA |
| N,N-dimethylarginine | NA | chemical - endogenous mammalian | Activated | 2.22e+00 | NA | 0.0e+00 | ACTA2,CLDN1,FN1,ICAM1,OCLN,PLAT,SERPINE1 | 1263 (18) |
| FERMT1 | 3.00e-01 | other | Activated | 2.22e+00 | NA | 0.0e+00 | LEF1,WNT2,WNT4,WNT5A,WNT6 | 1083 (7) |
| amoxicillin | NA | chemical drug | Activated | 2.22e+00 | NA | 0.0e+00 | IL1R1,TLR2,TLR4,TLR7,TLR8 | NA |
| MPST | 1.12e+00 | enzyme | Activated | 2.22e+00 | NA | 1.0e-02 | HIF1A,TIMM13,TIMM50,TOMM6,TOMM7 | NA |
| ING4 | 2.00e-02 | transcription regulator | Activated | 2.22e+00 | NA | 1.0e-02 | Ccl2,CDKN1A,CXCL10,NFKBIA,NFKBIB | 1303 (14) |
| miR-138-5p (miRNAs w/seed GCUGGUG) | NA | mature microRNA | Activated | 2.22e+00 | bias | 2.0e-02 | KRT19,LYPLA1,SLC45A3,TGFB1,VCAN | NA |
| gallic acid | NA | chemical - endogenous non-mammalian | Activated | 2.22e+00 | NA | 7.0e-02 | ADAM17,MMP2,PLAT,SELP,VCAM1 | NA |
| Cyp2c70 | 4.90e-01 | enzyme | Activated | 2.22e+00 | NA | 2.3e-01 | Ccl2,CXCL10,KRT19,TGFB1,TIMP1 | NA |
| IL37 | NA | cytokine | Activated | 2.22e+00 | NA | 3.7e-01 | CSF1,CXCL10,IL1RN,TIMP1,VCAM1 | NA |
| 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone | NA | chemical reagent | Activated | 2.22e+00 | NA | 2.0e-02 | CCND1,CCND2,CDK2,CDKN1A,GADD45A | NA |
| magnolol | NA | chemical - endogenous non-mammalian | Activated | 2.22e+00 | NA | 6.0e-02 | CDKN1A,CLEC11A,HIF1A,MMP2,PTGS2,TLR4 | NA |
| helenalin | NA | chemical - endogenous non-mammalian | Activated | 2.22e+00 | NA | 2.0e-01 | NFKBIA,PLA2G4A,PRDM1,PTGS2,TNFRSF10A | NA |
| CCN5 | NA | growth factor | Activated | 2.21e+00 | NA | 0.0e+00 | ACTA2,ADIPOQ,AXIN2,CCND1,CD44,CDH1,CLDN1,FN1,HIF1A,IGFBP7,ITGA5,KLF4,LAMC2,LPL,PPARG,SDC4,SERPINE1,SNAI2,SPARC,TGFB1,TWIST1,VIM | 1309 (20) |
| miR-208a-3p (and other miRNAs w/seed UAAGACG) | NA | mature microRNA | Activated | 2.21e+00 | bias | 2.0e-02 | ETS1,MYH7,PTGIR,RUNX2,SPP1 | NA |
| LRBA | -7.00e-02 | other | Activated | 2.21e+00 | NA | 8.0e-02 | Ccl2,CXCL10,FOXO1,FOXO3,IL17A,RDX | NA |
| ST8SIA1 | -5.20e-01 | enzyme | Activated | 2.21e+00 | NA | 2.6e-01 | C3,C3AR1,C5AR1,CDK2,CDKN1A | NA |
| LAMC1 | -1.00e-02 | other | Activated | 2.21e+00 | NA | 0.0e+00 | ACTA2,CDH11,EGR2,ETV5,FN1,SNAI2,VIM,WNT5A | 1281 (15) |
| ATAD3A | 1.01e+00 | other | Activated | 2.21e+00 | NA | 2.0e-02 | CDH1,IFI44L,IFIT1,ISG15,RSAD2 | NA |
| dihydroartemisinin | NA | chemical drug | Activated | 2.21e+00 | NA | 7.0e-02 | CCND1,CDK2,CDKN1A,MMP2,PTGS2 | NA |
| BMS-387032 | NA | chemical drug | Activated | 2.20e+00 | bias | 4.0e-02 | CCND1,CDK2,PDGFRA,SIX1,USP1 | NA |
| NKX6-1 | 1.62e+00 | transcription regulator | Activated | 2.20e+00 | NA | 1.1e-01 | GFRA1,MAFA,NR4A1,NR4A3,UNC5C | NA |
| miR-874-3p (miRNAs w/seed UGCCCUG) | NA | mature microRNA | Activated | 2.20e+00 | bias | 0.0e+00 | ACTA2,ADAM19,Ccl2,COL1A1,FN1 | NA |
| CD163 | -3.30e-01 | transmembrane receptor | Activated | 2.20e+00 | NA | 5.0e-02 | ALDH1A1,Ccl2,CD36,ICAM1,PROM1 | NA |
| nicardipine | NA | chemical drug | Activated | 2.20e+00 | NA | 2.0e-01 | BDNF,Ccl7,SELE,SELP,VCAM1 | NA |
| NGLY1 | -6.00e-02 | enzyme | Activated | 2.20e+00 | NA | 2.4e-01 | CXCL10,IFI44,IFI44L,IFIT1,NFE2L2,OAS3,RSAD2,USP18 | NA |
| letrozole | NA | chemical drug | Activated | 2.20e+00 | NA | 1.0e+00 | CCND1,CDK2,CDKN1A,MKI67,SYP | NA |
| Nr1h | NA | group | Activated | 2.20e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACADL,ACSL3,AGPAT1,ALDH1A1,APOD,ARNT2,ATP1B1,BCL3,C2,C3,CAV1,Ccl2,CCND2,CCR5,CSF1,CXCL10,EDN1,ELOVL4,ELOVL7,F2R,FGF1,GGT5,GLI1,GPAM,H6PD,HCK,HLA-DOB,IFIH1,ITGAL,LAT2,LPL,MARCKSL1,MPZ,MYLIP,NLRP3,NR5A2,PLA2G2A,PLIN1,PLTP,PRKCQ,PTCH1,PTGES,PTGS2,RGN,SBNO2,SELP,SFRP1,SP110,SREBF1,STAR,THBS1,THY1,TLR4,ZBTB16 | 1089 (23) |
| SPRY1 | NA | other | Activated | 2.20e+00 | NA | 0.0e+00 | AXIN2,ETV1,ETV5,FGF1,FGF10,FGF9,ID2,IGF1,ISG15,LOX,MMP14,MMP2,MYOCD,NR2F1 | 1168 (11) |
| etanercept | NA | biologic drug | Activated | 2.20e+00 | NA | 0.0e+00 | CD83,CXCL10,CXCL12,CXCL13,CYBB,FOXO3,GZMB,ICAM1,NCF1,NOX1,PTGES,PTGS2,Slco1a4,STAT1 | 1145 (14) |
| apigenin | NA | chemical - endogenous non-mammalian | Activated | 2.20e+00 | NA | 1.0e-02 | APLN,BCL2L1,CASP3,CASP8,Ccl2,CCND1,CCND2,CDK2,CDK6,CDKN1A,CREM,CSRP3,DPP4,DVL1,GCLC,HIF1A,ICAM1,IL17A,MYH6,PTGS2,SELE,SLC27A1,TAGLN,VCAM1 | 1200 (16) |
| prostaglandin A2 | NA | chemical - endogenous non-mammalian | Activated | 2.19e+00 | NA | 0.0e+00 | CCND1,CDKN1A,ELAVL1,ICAM1,IGF1,LPAR6,NR4A3,VCAM1 | 1304 (21) |
| chloropromazine | NA | chemical drug | Activated | 2.19e+00 | NA | 2.0e-02 | CD83,CYP4F2,DHCR7,FABP1,FADS2,LSS,MSMO1,MVK,NR4A1,NR4A2,NR4A3,PLCB1,TAGLN | NA |
| pentoxifylline | NA | chemical drug | Activated | 2.18e+00 | NA | 4.0e-02 | BCL2L1,Ccl2,CCND1,CCR5,COL1A1,CYBB,ICAM1,NFKBIA,REL,TGFB1,TIMP1,VCAM1 | NA |
| C1Q (family) | NA | group | Activated | 2.18e+00 | NA | 1.2e-01 | BCL2L11,CASP3,CASP8,CEBPD,ICAM1,MX1,SELE,STX3,VCAM1 | NA |
| fluocinolone acetonide | NA | chemical drug | Activated | 2.18e+00 | NA | 0.0e+00 | ACKR4,BCL2L1,BMP3,CXADR,FKBP5,IL33,ITGA10,JUND,KIF4A,KLF15,LIMCH1,PER3,PIR,PRKCB,RGCC,RUNX2,SOCS3,WNT4,ZBTB16 | 1199 (12) |
| picropodophyllin | NA | chemical drug | Activated | 2.18e+00 | NA | 1.0e-02 | CCND2,CD44,CDK6,ELN,HIF1A,IFITM3,PRDM1,ZBTB16 | 697 (7) |
| PTPN6 | -7.90e-01 | phosphatase | Activated | 2.18e+00 | NA | 0.0e+00 | BCL2L1,CASP3,Ccl2,CCND1,CD44,CD86,CDH2,CDK6,CXCL10,CYBB,ETS1,FN1,IRF1,ISG15,ITGB2,LYN,MMP2,NCF2,PTPN6,Tcf7,TIMP1,TNFRSF1B,VIM | 1018 (12) |
| mir-455 | NA | microRNA | Activated | 2.18e+00 | bias | 0.0e+00 | ACTA2,ADAMTS5,CCND1,COL1A1,HIF1AN,NDN,NOTCH2,RUNX1T1 | NA |
| PSME3 | 2.30e-01 | peptidase | Activated | 2.18e+00 | NA | 0.0e+00 | ACTA2,ALDOA,GAPDH,PGM1,PKM,SLC2A1,SREBF1,TAGLN | 1147 (11) |
| Go6983 | NA | chemical drug | Activated | 2.18e+00 | NA | 0.0e+00 | CD36,CLDN1,PPARG,PRDX1,PRKCD,PRKCE,PTGS2,SNAI1 | 1352 (18) |
| piceatannol | NA | chemical - endogenous non-mammalian | Activated | 2.18e+00 | NA | 2.0e-02 | ANGPT2,BCL2L1,BCL2L11,BCL6,BIRC3,Ccl2,CCND1,CCND2,EGLN1,ICAM1,MKI67,PTGS2 | NA |
| Bay 11-7082 | NA | chemical - kinase inhibitor | Activated | 2.17e+00 | NA | 0.0e+00 | ABCA1,ADORA2A,BCL2A1,BCL2L1,CASP1,Ccl2,Ccl7,CCND1,CD44,CD83,CHI3L1,CITED2,ELAVL1,F3,GLRB,HAX1,ICAM1,IL15RA,IL17A,IL2RB,MMP2,NLRP3,PTGS2,PYCARD,S100A4,SAMSN1,SIX4,TLR2,UCN2,VCAM1 | 1027 (14) |
| dexamethasone | NA | chemical drug | Activated | 2.17e+00 | NA | 0.0e+00 | AACS,ABCA1,ABCC3,ABCC8,ACADL,ACADS,ACKR3,ACKR4,ACOT7,ACSL1,ACSL3,ACTA2,ACTC1,ACTG1,ACTG2,Actn3,ADAM10,ADAM17,ADAMTS1,ADAMTS15,ADAMTS2,ADGRG3,ADHFE1,ADIPOQ,ADRA2A,ADRB2,AIF1,AKAP12,AKIRIN1,Akr1b7,ALCAM,ALDH18A1,ALDH1A1,ALOX15,ALOX5,AMIGO2,AMPD3,ANK2,ANKRD1,ANO1,ANO4,ANPEP,ANXA1,APLN,APOD,AQP7,ARHGAP24,ARHGEF2,ASNS,ATF3,ATN1,ATP1A1,ATP1B1,ATP2A2,ATP2B4,ATP9A,AUH,AXIN2,B2M,B3GALNT1,B3GNT5,BATF,BCAR1,BCAT2,BCKDHA,BCL2A1,BCL2L1,BCL2L11,BCL3,BCL6,BCR,BDKRB2,BDNF,BEST1,BGN,BHLHE40,BIRC3,BLVRB,BMP1,BMP5,BRCA2,BTG1,BTG2,C3,C3AR1,C5AR1,CALB1,CALCR,Calm1 (includes others),CARD6,CASP3,CASP8,CAV1,CAV2,Ccl2,CCL21,Ccl7,CCNA2,CCND1,CCND2,CCNE2,CCR1,CCR3,CD22,CD226,CD34,CD36,CD44,CD47,CD48,CD74,CD83,CD86,CDC42EP3,CDCA7L,CDH1,CDH11,CDH2,CDK2,CDKN1A,CDKN2C,CEACAM1,CEBPD,CELF2,CEP70,Ces1f,CFB,CFL1,CGGBP1,CHI3L1,CILP,CISH,CLEC11A,CLIC1,CLIC4,CMKLR1,CMTM5,CMTM6,CNN3,COL11A1,COL1A1,COL27A1,COL3A1,COL5A1,COL7A1,COX4I1,Cox8b,CP,CRHR2,CRP,CRYAB,CSF1,CSF1R,CSF2RB,CST7,CTNNAL1,CTSC,CTSE,CTSK,CX3CL1,CX3CR1,CXADR,CXCL10,CXCL12,CXCL14,CXCR4,CXCR5,CYBB,CYP1B1,CYP27A1,CYP2S1,CYSLTR1,DACH1,DALRD3,DAPK1,DAPK3,DCN,DCTN6,DDAH2,DDHD1,DDIT4,DGKG,DHRS1,DHRS9,DIO1,DLC1,DLK1,DLL1,DMP1,DPP4,DPYD,DPYSL3,DUSP1,DUSP10,DUSP5,E2F2,E2F8,EBF1,ECT2,EDARADD,EDEM1,EDN1,EDN3,EDNRB,EEF1A1,EGF,EGR1,EGR2,EGR3,EIF4EBP1,EIF6,ELAVL1,ELN,ELOVL1,EMILIN2,ENC1,ENO2,ENTPD1,EPB41L4B,EPSTI1,ERLIN1,ERRFI1,ETV5,EXT1,EYA2,EYA4,EZR,F2RL1,F3,F5,FA2H,FAM107A,FAM111A,FAM89B,FANCA,FANCB,FBLN1,FBN2,FBXO32,FCER1G,FCGR1A,FCGR2B,FCMR,FEN1,FGD4,FGF1,FGF10,FGF2,FGL2,FKBP5,FLRT2,FLT3LG,FN1,FOXC2,FOXO1,FOXO3,FOXP3,FSTL1,FTL,FZD4,G0S2,G6PD,GAB1,GADD45A,GADD45B,GAP43,GAPDH,GBP2,GBP5,GCGR,GCLC,GFOD2,GGCT,GLI1,GLUL,GNG10,GNG11,GP1BB,GPC3,GPR171,GPR183,GPR34,GPR65,GPR68,GRK5,GSR,GUK1,GZMB,H6PD,HERPUD1,HEY2,HGF,HIF1A,HLA-A,HLA-DOB,HLA-DRA,HLTF,HOMER2,HPD,ICAM1,ID2,IDH1,IER3,IFI44,IFIT1,IFITM3,IGF1,IGFALS,IGFBP4,IGFBP5,IGFBP6,IL10RA,IL16,IL17A,IL18R1,IL1R1,IL1RL1,IL1RL2,IL1RN,IL2RA,IL2RB,IL33,IL7,INHBA,INHBB,IP6K3,IQGAP1,IRAK3,IRF1,IRF2BP2,IRF3,IRF5,IRF8,IRS1,IRS2,ISG15,ITGA1,ITGA10,ITGA2,ITGA3,ITGA4,ITGA5,ITGB3,ITGB7,ITGBL1,ITPK1,JAG1,JAK3,JUND,KCNH2,KCNJ15,KCNK2,KCNK3,KCNK6,KDR,KIF4A,KIT,KLF15,KLF3,KLF4,KLF5,KLF6,KLF9,KNL1,LAD1,LAMA2,LAMA3,LAMA4,LBP,LDHB,LEF1,LGALS1,LGALS12,LITAF,LMCD1,LMO2,LOX,LPAR1,LPAR6,LPIN1,LPIN3,LPL,LSR,LSS,LTB4R,LTBP2,LY75,LYN,MAF,MAFF,MAN1C1,MAOB,MAP2,MAPK14,MAPK3,MAPK4,MAT2A,MC4R,MCM7,MEGF9,METTL7A,MFAP5,MGST1,MIA,MLXIP,MME,MMP14,MMP19,MMP2,MMP28,MOB1A,MRC1,MS4A6A,MSLN,MSR1,MSRB1,MSTN,Mt1,MTMR1,MUSK,MVK,MX1,MYCN,MYH6,MYL2,MYO10,MYOD1,MYOG,N4BP2L1,NAGK,NAV3,NCAM1,NCOR2,NDUFV1,NDUFV2,NECTIN3,NEDD4L,NET1,NEU1,NFIL3,NFKBIA,NHS,NLRC4,NLRP3,NMNAT1,NMNAT2,NOS1,NOTCH2,NOTCH4,NPR1,NPR2,NPR3,NR4A1,NR4A3,NTN4,NTS,OAS3,OASL,OCLN,OLFML2B,OLR1,OXTR,P2RY10,PAM,PARP14,PC,Pcsk1,PCSK5,PDE4D,PDGFRA,PDK2,PDK4,PDLIM1,PEBP1,PECR,PENK,PER1,PER3,PFKFB3,PHF6,PHLDA1,PHTF2,PIK3R1,PIR,PKP3,PLAT,PLD1,PLEK,PLIN1,PLK2,PLOD2,PLSCR4,PMM1,PMP2,PMP22,PNMT,PNPLA2,PNRC2,Podxl,POMGNT1,PPARD,PPARG,PRAG1,PRELP,PRKAA2,PRKAR2B,PRKCB,PRKCQ,PRKCZ,PRKG2,PRPF4B,PRRG4,PSD4,PTAFR,PTGES,PTGFRN,PTGS2,PTN,PTPN6,PTX3,PYGL,RAB11FIP3,RAPGEF4,RARA,RARG,RARRES1,RBL1,RBP7,RDH5,RET,RETN,RGCC,RGN,RGS10,RGS2,RGS4,RHOA,RNF128,RNF43,RRAD,RSAD2,RTP4,RUNX2,RXRA,S100A10,S100A4,SAMSN1,Scd2,SCNN1G,SELE,SELENBP1,SELENOP,SERPINB9,SERPINE1,SERPINF1,SERPING1,SESN1,SFRP1,SFTPB,SGK1,SHMT1,SIGLEC8,SLA,SLAMF1,SLC10A6,SLC19A2,SLC1A3,SLC25A22,SLC25A33,SLC25A34,SLC2A1,SLC2A5,SLC35D1,SLC38A4,SLC39A10,SLC45A3,SLC46A3,SLC7A6,SLC9A1,SLC9A3,Slco1a4,SLCO2A1,SLCO2B1,SMPDL3B,SNAI1,SNAI2,SOAT1,SOCS1,SOCS3,SORD,SORT1,SPARC,SPECC1,SPHK1,SPP1,SREBF1,SRSF4,SSBP3,ST3GAL1,ST6GAL1,STAR,STAT1,STK3,STRA6,STYX,SULF2,SYBU,SYK,TAGLN,TBC1D10B,TBXAS1,TEK,TFPI2,TGFA,TGFB1,TGFBI,TGIF2,THBD,THBS1,THBS2,TIMP1,TLE2,TLR2,TLR4,TLR5,TLR8,TMEM176B,TNC,TNFAIP2,TNFAIP6,TNFRSF10A,TNFRSF11B,TNFRSF19,TNFRSF25,TNFRSF4,TNNT1,TOP2A,TPH1,Tpi1 (includes others),TRERF1,TRIM63,TRPM2,TRPV1,TSFM,TSPAN2,TSPAN33,TST,TWF1,TWF2,TYMS,UBC,UBE3A,UCN2,UCP3,UGCG,USF2,USP18,VCAM1,VCAN,VCP,VEGFC,VIM,WIPF1,WNT2,WNT2B,WNT4,WNT5A,ZBTB16,ZBTB20,ZDHHC2,ZFP36,ZFP36L1,ZFP36L2,ZNF189,ZNF48,ZNRF1 | 1755 (16) |
| CLUH | 1.20e-01 | translation regulator | Activated | 2.17e+00 | NA | 2.5e-01 | ACAD8,ACADS,ENPP3,HLA-A,ISG15,MICU1,MRPL13,MRPL22,NDUFS7,STAT1,Tha1,TSFM | NA |
| mir-133 | -1.84e+00 | microRNA | Activated | 2.17e+00 | NA | 0.0e+00 | ARL3,ATP6AP2,CCND2,CD34,CMTM6,CNN1,CORO1C,ELAVL1,FBN2,FN1,FSCN1,FTL,HCN4,KCNH2,KLF15,LASP1,MET,MMP14,MSN,PITX3,PPARG,RHOA,SNCA,TAGLN,TNNT2,VCAN | 1133 (12) |
| enalapril | NA | biologic drug | Activated | 2.17e+00 | NA | 0.0e+00 | A2M,ACTA2,ADAMTS1,ANGPT2,ASNS,Ccl2,Ccl7,CENPF,CITED2,COL1A1,COL3A1,CP,CYBA,FBLIM1,FBN1,FN1,GCGR,GPX3,HGF,IER3,KDR,LOX,LTBP2,MMP14,MMP2,NINJ1,PTGS2,S100A10,S100A4,S100A6,SERPINE1,SPP1,TGFB1,TIMP1,VCAM1 | 1452 (21) |
| miR-320b (and other miRNAs w/seed AAAGCUG) | NA | mature microRNA | Activated | 2.17e+00 | bias | 0.0e+00 | AQP4,HSPB6,IGF1,TAGLN,VIM | NA |
| BB-Cl-amidine | NA | chemical reagent | Activated | 2.16e+00 | NA | 1.0e-02 | ACTA2,COL1A1,FN1,IGF1,MYCN | 662 (7) |
| amitriptyline | NA | chemical drug | Activated | 2.16e+00 | NA | 2.0e-02 | BDNF,CASP1,CCND2,CDKN1A,FABP1,FGF2,GPATCH3,LSS,TAGLN | NA |
| let-7 | -8.60e-01 | microRNA | Activated | 2.16e+00 | bias | 0.0e+00 | ACTA2,ACVR1C,BCAT1,BCL11A,BCL2L1,BDNF,BOP1,BRCA2,BTG2,BUB1,BUB1B,C14orf28,Calm1 (includes others),CASP3,CBFB,CCNA2,CCND1,CCNE2,CD44,CDC34,CDH2,CDK6,CEBPD,COL1A1,COL27A1,COL3A1,COL5A2,CPEB3,DLC1,DUSP6,DZIP1,E2F2,E2F5,E2F8,EDEM1,EDEM3,EZH2,FARP1,FN1,GPI,GPX7,HBA1/HBA2,ID2,IGF1,IL17A,IRS2,ITGA1,ITGA4,ITGB3,LEF1,MCM7,MCM8,MYCN,NXT2,PKM,PLAGL1,PROM1,PTGS2,RDH10,RFC2,RFC5,S100A4,SALL4,SERPINE1,SKP2,SLC1A4,STAR,STARD13,TBX5,THBS1,TLR4,TMPRSS2,TRIB1,VIM,ZC3H3,ZFP36 | 1342 (18) |
| mir-34 | NA | microRNA | Activated | 2.14e+00 | NA | 0.0e+00 | ACTA2,AXL,BIRC3,CCDC71L,CCND1,CCND2,CCNE2,CD47,CDK6,CNTN2,COL1A1,CREB1,CSF1R,DLL1,E2F5,EMP1,FN1,GNAI1,HIF1A,ITGA2B,KCNH2,KLF10,LEF1,LYST,MET,MYCN,NCAPG2,NOTCH2,PFKFB3,PKM,RUNX2,SEMA3C,SHPK | 1460 (23) |
| mir-19 | NA | microRNA | Activated | 2.14e+00 | NA | 0.0e+00 | ABCA1,ALOX5,BCL2L11,CCND2,CDKN1A,Cox8b,E2F2,F3,FZD4,MAPK14,MSMO1,MYH7,MYLIP,PRKAA1,RAPGEF4,SOCS3,THBS1,TLR7,TP63 | 1254 (13) |
| amlodipine | NA | chemical drug | Activated | 2.14e+00 | NA | 0.0e+00 | ACTA1,ANXA2,COL1A1,EDN1,IGFBP5,MYH7,PTGS2,S100A10 | 1327 (18) |
| KDM3B | 2.30e-01 | enzyme | Activated | 2.13e+00 | NA | 0.0e+00 | ADAMTS1,ADRA2A,APOD,ARL6IP1,AXIN2,C1R,CIT,COLEC12,CORO1C,DAPK1,DEPDC1,DIO1,FADS2,FN1,IGF1,IRS1,KIF26B,KNL1,MAP7D1,MB,NCAPG,NEDD4L,PALLD,PPP3CA,PRUNE2,SLC44A1,STMN1,TSHZ3,ZNF503 | NA |
| KL | -5.10e-01 | enzyme | Activated | 2.13e+00 | NA | 0.0e+00 | ACTA2,ADAM10,ADAM17,ATF3,AXL,BCL2L1,Ccl2,CCND1,CDKN1A,CYBB,EGR1,FN1,ICAM1,KDR,MITF,MMP2,RUNX2,SCX,SELP,TGFB1,TNFRSF11B,TYRO3,VIM | 1601 (19) |
| soloxolone methyl | NA | chemical reagent | Activated | 2.12e+00 | bias | 0.0e+00 | Ccl2,ELN,IFI44,RSAD2,RTP4,SERPINE1,SOCS3,TIMP1 | NA |
| ARHGDIG | NA | other | Activated | 2.12e+00 | bias | 1.0e-02 | ALCAM,ANXA1,COL5A2,DUSP6,EDN1,LPAR1,PALLD,RGS2 | NA |
| UPF1 | 2.90e-01 | enzyme | Activated | 2.12e+00 | NA | 2.4e-01 | BIRC3,CDH1,IL2RA,IQGAP1,ITGA5,NRM,PYGL,SGK1 | NA |
| miR-143-3p (and other miRNAs w/seed GAGAUGA) | NA | mature microRNA | Activated | 2.12e+00 | bias | 0.0e+00 | AXL,FSCN1,IGFBP5,ITGA6,MITF,PDGFRA,PLK1,PRC1,PRKCE,SOX10,TAGLN,TOP2A | 340 (5) |
| miR-19b-3p (and other miRNAs w/seed GUGCAAA) | NA | mature microRNA | Activated | 2.12e+00 | NA | 4.0e-02 | ALOX5,BCL2L11,CCND1,Cox8b,MYLIP,NR4A2,THBS1,TLR5 | NA |
| PTGER4 | -4.80e-01 | G-protein coupled receptor | Activated | 2.11e+00 | NA | 0.0e+00 | ACTA2,ARRDC3,Ccl2,Ccl7,CD44,CDK6,CITED2,CP,CXCL10,CXCR4,CYBB,EDN1,EGR1,Fnbp1l,FOXP3,GAB1,GBP2,GBP4,HAS2,HCAR2,HERC6,HERPUD1,HGF,HIVEP3,ICAM1,IFI16,Ifi47,IFIH1,IL4I1,IRF1,LHFPL2,LPAR6,MAFF,MMP2,NCF1,NCF2,NOX1,OLR1,PARP14,PDGFB,PDK2,PTGER3,PTGS2,RASSF2,RNF213,RSAD2,RTP4,RUNX2,SAP30,SHISA3,SLAMF1,SLFN13,SPP1,ST6GAL1,ST8SIA4,TAGLN2,TLR8,TOR3A,USP18,ZFP36L1 | 1500 (16) |
| ADAMTS12 | -3.60e-01 | peptidase | Activated | 2.11e+00 | bias | 0.0e+00 | ALDH1A3,CHI3L1,CXCL10,HDC,IL33,LGALS1,MID1,S100A6,SELP,TAGLN,TNFAIP2 | NA |
| HNF4G | -1.07e+00 | transcription regulator | Activated | 2.11e+00 | NA | 1.5e-01 | CNN3,DAAM1,FBLIM1,FHL3,FLNA,ITGA2,ITGA5,LAMC2,PDLIM1,PDLIM7,TRIP6 | NA |
| mir-145 | NA | microRNA | Activated | 2.11e+00 | NA | 0.0e+00 | ABCA1,ACTA2,ADAM17,CCNA2,CD28,CDH2,CDK6,COL5A1,DMP1,EIF2AK3,FGF10,FSCN1,IRS1,KLF5,MYOCD,PDE3B,PDGFRA,PRKCE,ROCK1,TAGLN | 1520 (23) |
| COL6A1 | -5.00e-01 | other | Activated | 2.11e+00 | NA | 0.0e+00 | AK1,ALDOA,CKM,COL6A5,COL6A6,ENO3,IDH1,PVALB,ROCK1,TNC,TNNI2 | NA |
| tyrphostin AG490 | NA | chemical drug | Activated | 2.11e+00 | NA | 0.0e+00 | A2M,ACTA2,BCL2L1,BIRC3,CASP3,Ccl2,CDKN1A,CTSK,DUOX2,EDN1,FGF2,FOXP3,GFAP,HIF1A,ICAM1,IGF1,IL17A,IL7,IRF1,ITGAE,LMO2,LYN,MYH10,OCLN,PLA2G2A,PTGS2,PTX3,RETN,S100A10,SFTPB,SOCS3,SPP1,STAR,STAT1,TAGLN,TIMP1,TWIST1 | 1316 (16) |
| N,N-dimethylsphingosine | NA | chemical reagent | Activated | 2.10e+00 | NA | 0.0e+00 | FN1,GCH1,ICAM1,PTGS2,SELE,SPHK1,VCAM1 | 1048 (18) |
| PCGF2 | -7.30e-01 | transcription regulator | Activated | 2.09e+00 | NA | 0.0e+00 | CCND2,CDH1,CDH2,CDK6,FN1,HOXD4,IL17A,JAG1,PDE3B,SNAI1,USF2,VAT1L,VIM,ZEB2 | 1430 (25) |
| ibuprofen | NA | chemical drug | Activated | 2.09e+00 | NA | 1.0e-02 | CCND1,CD36,COL12A1,CYBB,DCN,EDNRB,GFAP,HIF1A,MAGI1,MMP2,PPARG,PTGS2,PTPRC,SLC2A1 | 1482 (23) |
| 4-(2-aminoethyl)benzenesulfonylfluoride | NA | chemical - protease inhibitor | Activated | 2.09e+00 | NA | 1.0e-02 | CDKN1A,COL11A1,COL1A1,DMP1,ENPP3,FBN2,FN1,MITF,SCN1A,SPN,TAGLN,TNC | 945 (19) |
| UPF2 | 3.30e-01 | other | Activated | 2.07e+00 | NA | 1.0e-02 | BMP5,CACNA1D,CACNB2,CXCL10,KHDRBS3,NRP1,PTGS2,PYGM,RERGL,TNFRSF11B,TSPAN8 | NA |
| hydrocortisone | NA | chemical - endogenous mammalian | Activated | 2.07e+00 | NA | 0.0e+00 | ADAM17,ALDH18A1,ALOX15,ANKRD1,AQP4,BDKRB2,BRCA2,CASP3,CCND1,CCND2,CD86,CDH11,CDH2,CEBPD,COL1A1,CXCR4,ERRFI1,EZR,FGF2,FGF9,FN1,GADD45B,GAP43,GLUL,GNAS,H6PD,HGF,ICAM1,IGF1,IGFBP4,IGFBP5,IGFBP6,IGFBP7,IL2RA,INHBA,ITGA2,LOX,LPL,LY75,MC2R,Mt1,NFKBIA,NOTCH4,NTRK2,PLA2G4A,PLAT,PPARG,PROX1,PTGS2,PTPN4,SELE,SERPINE1,SFRP1,SMO,TLE2,TLR2,TNFAIP2,TNFRSF11B,TUBB,VIM | 1567 (15) |
| mir-210 | NA | microRNA | Activated | 2.07e+00 | NA | 0.0e+00 | ABCB9,ABCC3,ACVR1B,ARG1,ATP11C,BDNF,CDCA7L,CDH1,CDH2,CXCL12,ELK3,EPB41L1,EPHA3,FAM102A,FKBP9,FOXP3,IL16,INHBB,ISCU,KDR,KLF6,LASP1,LEF1,NCAM1,NUP210,SCARA3,SH3BGRL,STAT6,STMN1,TERF2IP | NA |
| TSHZ3 | -1.22e+00 | transcription regulator | Activated | 2.06e+00 | NA | 0.0e+00 | ACVR1C,AMPD3,BHLHE22,COL23A1,COL5A1,CRYM,CXXC5,ECHDC2,FGF10,FMOD,GDF10,HS3ST3B1,IGSF21,LDB2,MYOG,NR4A1,PTGER3,SLA,VAT1 | NA |
| LRP1 | -5.70e-01 | transmembrane receptor | Activated | 2.06e+00 | NA | 0.0e+00 | ACTA1,ADGRE1,C1R,Ccl2,CDH1,CDH2,COL3A1,CREB1,GLI2,GSR,MMP2,MRC2,PPIA,PRDX4,PRDX5,PTGS2,SERPINF1,SERPING1,SMO,WNT10B,WNT5A | 1024 (19) |
| TRPS1 | -4.50e-01 | transcription regulator | Activated | 2.06e+00 | NA | 0.0e+00 | ACSL1,BUB1,CCNA2,CENPF,DPEP2,FN1,KIF11,MMP2,NOTCH2,RANBP3L,RUNX1,RUNX2,SERPING1,SMPD3,SNAI1,SNAI2,SPC25,TOP2A | 1392 (11) |
| 3-aminobenzamide | NA | chemical toxicant | Activated | 2.05e+00 | NA | 6.0e-02 | BRCA2,CDKN1A,COL1A1,COL3A1,ICAM1,ITGAL,TIMP1 | NA |
| miR-204-5p (and other miRNAs w/seed UCCCUUU) | NA | mature microRNA | Activated | 2.05e+00 | bias | 1.0e-02 | ACVR1,BMP1,CAMK2D,CBFB,CDC25B,CDH11,CHRNA1,CTSC,FBN2,ID2,ITGB4,LTBP1,PIK3R1,PPARG,ROCK1,SMAD9,SPARC,SPDEF | NA |
| TAB1 | 3.50e-01 | enzyme | Activated | 2.04e+00 | NA | 0.0e+00 | BIRC3,CDKN1A,CFB,CXCL10,GBP2,GCH1,IFIH1,IFIT1,NFKBIA,PTGS2,RGS2,SELE,SERPINE1 | 622 (13) |
| tyrphostin AG 1478 | NA | chemical drug | Activated | 2.04e+00 | NA | 0.0e+00 | BCL2L1,CAV1,CCND1,CDKN1A,COL8A1,CXCR4,EDN1,EGF,ELN,F3,FAP,FBN1,FOXO3,HAS2,HIF1A,ICAM1,IRF1,ITGA2,MME,MMP2,NCF1,NCF2,PLAGL1,PTGS2,PTX3,RUNX1,RUNX2,S100A10,SLC2A1,SPHK1,TFPI2,TNFAIP6,TWIST1,VCAM1 | 1246 (14) |
| RAD21 | -3.60e-01 | transcription regulator | Activated | 2.04e+00 | NA | 0.0e+00 | ATP1B1,BDNF,CLMP,CXCL12,FOXP3,FZD1,HLA-DQA1,HLA-DRA,IRS2,ITGA5,KCNA1,KLF5,NXPH3,PCDHA4,PCDHGB7,SNAI2,ST8SIA2,TGFB1,THBS1,VIM | 1565 (17) |
| mifepristone | NA | chemical drug | Activated | 2.04e+00 | NA | 0.0e+00 | ABCC3,ADIPOQ,ALOX15,ANXA1,ARG1,ATF3,B2M,BCAT1,BCL2L1,C3,CAMK2D,CASP1,CASP3,CASP8,CAV1,Ccl2,CCND1,CD74,CDH2,CDKN1A,CEACAM1,CEBPD,CHI3L1,CISH,CKMT1A/CKMT1B,CLDN3,CLEC3B,COL18A1,COL2A1,COL5A2,CYBA,CYBB,DDIT4,DKK3,DLC1,DPP4,DUSP1,EDNRB,EGR1,EGR2,ERRFI1,F3,FCGR2B,FGF2,FKBP5,FN1,H6PD,HAS2,HDAC7,HDC,HLA-A,ICAM1,INHBB,IQGAP1,IRS2,ITGA2,ITGA4,ITGB3,ITGB4,JAK3,JAM2,KIT,KLF4,KLF9,LAMA2,LAMC2,LOX,LSR,MAP4K1,MME,Mt1,NCOR2,NDN,NFE2L2,NFKBIA,NOX4,NPL,NR4A1,OGN,OXTR,PC,PDGFRA,PFKFB3,PLA2G4A,PLAT,PLK2,PRKG2,PTGIS,PTGS2,PTN,PTX3,RAP1GAP,RARA,RBL1,RELN,REM1,RGS2,RUNX2,S100A6,SERPINE1,SERPING1,SFRP1,SFRP2,SFRP4,SLC2A1,SNAI1,SNAI2,SPEG,SPP1,STAR,TGFB1,THBS2,TIMP1,TMPRSS2,TNFAIP6,UCN2,VCAN | 1710 (18) |
| MI-503 | NA | chemical reagent | Activated | 2.04e+00 | NA | 0.0e+00 | ACTA2,ARID3B,CCND2,CDH1,DDIT4,FN1,JUND,SNAI1,SPP1,TGFB1,TWIST1 | 807 (10) |
| HEXIM1 | 5.00e-01 | transcription regulator | Activated | 2.04e+00 | NA | 1.0e-02 | ANXA1,CCND1,CDKN1A,COL1A1,FGF2,FGF9,HIF1A,LOXL2,SLC2A1,VIM | 1494 (24) |
| 4-hydroxycinnamyl aldehyde | NA | chemical - endogenous non-mammalian | Activated | 2.04e+00 | NA | 0.0e+00 | BCL2L1,CDH2,MIA,MMP2,RHOA,S100B,VIM | 677 (9) |
| l-asparaginase | NA | biologic drug | Activated | 2.03e+00 | NA | 0.0e+00 | ALDH1L2,ASNS,BARD1,BDH2,BTG2,BUB1,BUB1B,CCNA2,CCNE2,CDKN1A,CENPF,DHCR7,E2F7,EXTL1,KIF11,KIF4A,KNL1,KNTC1,LIPG,MSMO1,MTHFD2,MVD,NCAPG,PHGDH,PLAGL1,PLK1,PLK4,RBL1,REM1,SGO1,SMC2,SPC25,TOP2A | NA |
| SOX6 | 1.25e+00 | transcription regulator | Activated | 2.03e+00 | NA | 1.0e-02 | CCND1,CDKN1A,COL2A1,MYH7B,MYL1,MYL3,RUNX2,SOCS3,TNNC1,TNNI2 | 1354 (24) |
| SFRP4 | -2.12e+00 | transmembrane receptor | Activated | 2.01e+00 | NA | 0.0e+00 | AXIN2,CCND1,CDH1,FN1,GREM1,GREM2,INHA,MYH6,MYH7,NTS,PTGS2,SFRP2,TNNT2,TWIST1,VIM | 1182 (11) |
| DIM-C-pPhOH-3-Cl-5-OCH3 | NA | chemical reagent | Activated | 2.01e+00 | NA | 0.0e+00 | ACTA1,COL1A1,FN1,GPD1,NR4A1,PGAM2,PHKG1,PYGM | NA |
| mir-9 | NA | microRNA | Activated | 2.01e+00 | NA | 1.0e-02 | BCL6,CDH1,CXCR4,ETS1,JAK3,PMP22,PRDM1,RUNX1,RUNX1T1,ZFP36 | NA |
| TMPRSS6 | -3.40e-01 | peptidase | Activated | 2.00e+00 | NA | 1.0e-02 | CDH2,CDKN1A,PROM1,SERPINE1,SNAI1,VIM,ZEB2 | 850 (16) |
| GSK3B | -4.70e-01 | kinase | Activated | 2.00e+00 | NA | 0.0e+00 | ATP2A2,BCL2A1,BCL2L1,BIRC3,Ccl2,Ccl7,CCND1,CCNE2,CDH11,CDKN1A,CKM,DLL1,EZH2,GATA4,GFPT2,GLI1,HIF1A,IFT27,IRS2,ISG15,KDR,MPZ,MYH6,MYOG,OCLN,PMP22,PTGS2,SELP,SERPINE1,SLC16A1,SNAI1,SNAI2,SPP1,SREBF1,TNNC1,TP63,TUBB4A | 1471 (21) |
| BC-11 | NA | chemical reagent | Activated | 2.00e+00 | bias | 0.0e+00 | ACTA2,COL3A1,COL5A1,FN1 | 561 (7) |
| Integrinα | NA | group | Activated | 2.00e+00 | bias | 0.0e+00 | ITGAL,ITGB2,TLR2,TLR4 | 1229 (7) |
| miR-380-3p (miRNAs w/seed AUGUAAU) | NA | mature microRNA | Activated | 2.00e+00 | bias | 0.0e+00 | CDH1,CDH2,SNAI2,TWIST1 | NA |
| CDH4 | -1.00e-01 | other | Activated | 2.00e+00 | bias | 0.0e+00 | CDH1,CDH3,MMP2,PTGS2 | NA |
| silicon phthalocyanine | NA | chemical drug | Activated | 2.00e+00 | NA | 0.0e+00 | CCND1,CDK2,CDK6,CDKN1A | 1302 (17) |
| ERW1041E | NA | chemical reagent | Activated | 2.00e+00 | bias | 1.0e-02 | ACTA2,COL1A1,FN1,TGFB1 | NA |
| Gm19378 | NA | other | Activated | 2.00e+00 | NA | 1.0e-02 | FBXO32,MYOD1,PIK3R3,TRIM63 | NA |
| SERPIND1 | -6.10e-01 | other | Activated | 2.00e+00 | bias | 1.0e-02 | Ccl2,EGR1,F2R,KLF5 | 556 (7) |
| LGK-974 | NA | chemical drug | Activated | 2.00e+00 | bias | 1.0e-02 | AXIN2,COL6A3,LEF1,NKD1 | NA |
| CXXC4 | -1.07e+00 | other | Activated | 2.00e+00 | NA | 1.0e-02 | CCND1,CDKN1A,EPHB2,SPARC | 1432 (19) |
| CTH | NA | enzyme | Activated | 2.00e+00 | NA | 2.0e-02 | ASNS,CDKN1A,CX3CR1,HIF1A | NA |
| HERC2 | 6.00e-01 | enzyme | Activated | 2.00e+00 | NA | 3.0e-02 | CASP1,NLRC4,PYCARD,USP16 | NA |
| Gstt1 | -4.20e-01 | enzyme | Activated | 2.00e+00 | bias | 3.0e-02 | CHST7,EPHX1,Gsta4,PTGES | NA |
| hydralazine | NA | chemical drug | Activated | 2.00e+00 | NA | 3.0e-02 | GRK5,MMP2,MYH7,SELP | NA |
| AJUBA | 1.00e-01 | transcription regulator | Activated | 2.00e+00 | NA | 4.0e-02 | BCAR1,BUB1,CDC25B,CDH1,WEE1 | NA |
| genipin | NA | chemical - endogenous non-mammalian | Activated | 2.00e+00 | NA | 5.0e-02 | CCND1,CDK2,CDK6,CDKN1A | NA |
| salinomycin | NA | chemical - endogenous non-mammalian | Activated | 2.00e+00 | NA | 1.0e-01 | ACTA2,CCND1,FN1,LEF1 | NA |
| chlorcyclizine | NA | chemical drug | Activated | 2.00e+00 | NA | 1.2e-01 | FABP1,GPATCH3,LSS,TAGLN | NA |
| brusatol | NA | chemical reagent | Activated | 2.00e+00 | NA | 1.2e-01 | CXCL10,ICAM1,SERPINE1,VCAM1 | NA |
| perhexiline | NA | chemical drug | Activated | 2.00e+00 | NA | 1.6e-01 | FABP1,GPATCH3,LSS,TAGLN | NA |
| latrunculin A | NA | chemical toxicant | Activated | 2.00e+00 | NA | 1.6e-01 | ACTA2,CXCL10,HAS2,TRPV1 | NA |
| hydroxyflutamide | NA | chemical drug | Activated | 2.00e+00 | NA | 2.3e-01 | IGF1,MSN,UGDH,VCAM1 | NA |
| mir-290 | NA | microRNA | Activated | 2.00e+00 | NA | 2.7e-01 | CDK2,PRKAA1,RECK,SALL4 | NA |
| IACS-010759 | NA | chemical drug | Activated | 2.00e+00 | NA | 2.7e-01 | GPSM2,HGF,RPL14,RPL37A | NA |
| pyridostigmine | NA | chemical drug | Activated | 2.00e+00 | NA | 2.7e-01 | Ccl2,CXCL10,IL7,MYH7 | NA |
| SLC29A1 | -5.40e-01 | transporter | Activated | 2.00e+00 | NA | 3.9e-01 | CDKN1A,GADD45A,ITGA5,SESN1 | NA |
| edaravone | NA | chemical drug | Activated | 2.00e+00 | NA | 4.7e-01 | BCL2L11,CASP3,Ccl2,GSR | NA |
| miR-455-3p (miRNAs w/seed CAGUCCA) | NA | mature microRNA | NA | 2.00e+00 | bias | 5.0e-02 | ACTA2,CCND1,COL1A1,NOTCH2 | NA |
| EGFL7 | NA | other | NA | 2.00e+00 | NA | 1.0e-02 | ICAM1,NFKBIA,SELE,VCAM1 | NA |
| meloxicam | NA | chemical drug | NA | 1.99e+00 | NA | 1.6e-01 | CDKN1A,HIF1A,PTGES,PTGS2 | NA |
| CTNNBIP1 | 1.19e+00 | other | NA | 1.99e+00 | NA | 1.6e-01 | AXIN2,CCND1,CDKN1A,NEDD9 | NA |
| GSE1 | 1.70e-01 | other | NA | 1.99e+00 | NA | 0.0e+00 | ART3,CD48,CD86,ICAM1,IFI16,IL1RN,IRF8,LY86,NAV3,OSBPL11,PCOLCE,RILPL1,SLC1A3,SLC27A1 | NA |
| N(1)-methylnicotinamide | NA | chemical - endogenous mammalian | NA | 1.99e+00 | bias | 2.0e-02 | ACTA2,Ccl2,COL1A1,FN1 | NA |
| SIRT3 | -3.40e-01 | enzyme | NA | 1.99e+00 | NA | 1.0e+00 | ACTA2,CASP3,Ccl2,MYH7,SLC2A1,SREBF1,STAR,VIM | NA |
| UMI-77 | NA | chemical reagent | NA | 1.98e+00 | bias | 0.0e+00 | ACTA2,TGFB1,TWIST1,VIM | 873 (14) |
| DIM-C-pPhOH-3-Cl | NA | chemical reagent | NA | 1.98e+00 | bias | 1.0e-02 | NR4A1,PGAM2,PHKG1,PYGM | NA |
| AP20187 | NA | chemical reagent | NA | 1.98e+00 | NA | 1.0e-02 | ADIPOQ,ANXA1,BDNF,CXCL13,EGR1,PTGS2,RETN | NA |
| DIM-C-pPhOH-3,5-Br2 | NA | chemical reagent | NA | 1.98e+00 | bias | 2.0e-02 | NR4A1,PGAM2,PHKG1,PYGM | NA |
| ADGRF5 | 4.20e-01 | G-protein coupled receptor | NA | 1.98e+00 | bias | 3.0e-02 | Ccl2,CSF1,IL1RN,MMP2 | NA |
| mefunidone | NA | chemical reagent | NA | 1.98e+00 | NA | 5.0e-02 | ACTA2,NOX4,SNAI1,TGFB1 | NA |
| TAS1R3 | 1.25e+00 | G-protein coupled receptor | NA | 1.98e+00 | NA | 1.0e-01 | DDIT4,PPARG,SLC16A1,SLC1A5 | NA |
| nedocromil sodium | NA | chemical drug | NA | 1.98e+00 | NA | 1.0e-01 | ANGPT2,COL3A1,MMP2,TGFB1 | NA |
| tyrphostin AG 1296 | NA | chemical drug | NA | 1.98e+00 | NA | 1.0e-01 | Ccl2,ICAM1,PTGS2,TGFB1 | NA |
| C1q | NA | complex | NA | 1.98e+00 | NA | 2.7e-01 | ICAM1,IRF5,SELE,VCAM1 | NA |
| SMARCE1 | 3.00e-02 | transcription regulator | NA | 1.98e+00 | NA | 5.1e-01 | BRCA2,CENPF,L1CAM,MYOG | NA |
| GLP-1-(7-34)-amide | NA | biologic drug | NA | 1.98e+00 | NA | 5.1e-01 | LPL,NR4A1,PPARG,VCAM1 | NA |
| miR-137-3p (miRNAs w/seed UAUUGCU) | NA | mature microRNA | NA | 1.98e+00 | bias | 1.0e-02 | CDK6,KIT,MITF,TNC | NA |
| MK2 inhibitory peptide | NA | biologic drug | NA | 1.98e+00 | bias | 5.0e-02 | ACTA2,COL3A1,FN1,LOX | NA |
| miR-219a-5p (and other miRNAs w/seed GAUUGUC) | NA | mature microRNA | NA | 1.98e+00 | bias | 1.0e-02 | ALOX5,ELOVL7,PLCG2,TNFRSF1B | NA |
| (6)-gingerol | NA | chemical - endogenous non-mammalian | NA | 1.98e+00 | NA | 2.0e-02 | CDK2,CDK6,CDKN1A,PTGS2 | NA |
| N(6)-(3-iodobenzyl)-5’-N-methylcarboxamidoadenosine | NA | chemical drug | NA | 1.98e+00 | NA | 3.5e-01 | CCND1,RGS2,RGS4,SLC9A1 | NA |
| oleoyl-estrone | NA | chemical drug | NA | 1.98e+00 | NA | 5.8e-01 | ADCY4,G6PD,LPL,SLC27A1 | NA |
| ramipril | NA | chemical drug | NA | 1.98e+00 | NA | 1.0e-02 | COL1A1,COL3A1,DDR1,FN1,ITGA2,MAPK14,MMP2,PTGS2,TGFB1,TIMP1,TLR4 | 1259 (13) |
| N6-cyclopentyladenosine | NA | chemical reagent | NA | 1.97e+00 | bias | 3.0e-02 | GRIA2,RGS2,RGS4,SLC9A1 | NA |
| PEMT | -1.60e-01 | enzyme | NA | 1.97e+00 | NA | 7.0e-02 | ADGRE1,COL1A1,GCGR,HERPUD1,TIMP1 | NA |
| dehydrocostus lactone | NA | chemical - endogenous non-mammalian | NA | 1.97e+00 | NA | 1.2e-01 | CDK2,ITGB3,MMP2,PRKCB | NA |
| CDK1 | -3.80e-01 | kinase | NA | 1.97e+00 | NA | 2.6e-01 | Ccl2,CDKN1A,CXCL10,IL1RN,MAP2,TIMP1 | NA |
| BAPTA | NA | chemical reagent | NA | 1.97e+00 | NA | 5.5e-01 | CA9,MYL2,PTGS2,SELP | NA |
| SETDB1 | -1.40e-01 | enzyme | NA | 1.97e+00 | NA | 0.0e+00 | ACTA2,ANGPT2,ANO2,CDH1,CDH2,CSMD1,FN1,GPM6A,ID2,IFI44,IFI44L,NFE2L2,PIK3C2G,PTPRZ1,ROBO2,SNAI1,ZNF420 | 1615 (23) |
| SPINT1 | -7.60e-01 | other | NA | 1.96e+00 | bias | 1.0e-02 | APCDD1,FZD6,IGFBP4,PROX1,Tcf7,WNT11,WNT5A | NA |
| GSK3A | 6.20e-01 | kinase | NA | 1.96e+00 | NA | 2.0e-02 | GATA4,GSK3A,IRS1,KDR,MYH6,SELP,SERPINE1,TNNC1 | NA |
| ATXN1 | 3.20e-01 | transcription regulator | NA | 1.96e+00 | NA | 1.0e+00 | ATP2A2,CD44,ETV5,MTSS1,TRPC3 | NA |
| NEUROG1 | NA | transcription regulator | NA | 1.96e+00 | NA | 0.0e+00 | ADD3,AMIGO2,C3,CCND2,CDK5R1,CFH,COL3A1,FAP,FGF9,FN1,GAS2,GFPT2,GREM1,HAS2,INHBA,ITGB3,LCP1,LGR5,LIX1,PLK2,PPIC,PXDN,RHOA,S100A4,SERPINF1,THBS1 | 565 (7) |
| PCBP1 | 3.90e-01 | translation regulator | NA | 1.96e+00 | NA | 3.0e-02 | ALOX15,CD44,INHBA,MYH10 | NA |
| miR-155-5p (miRNAs w/seed UAAUGCU) | NA | mature microRNA | NA | 1.96e+00 | bias | 0.0e+00 | AMIGO2,BACH1,BCL2L11,CASP1,CBFB,Ccl2,CCND1,CD47,CLDN1,CSF1R,CUX1,DNAJB1,ETS1,FADD,FADS1,FAR1,FGD4,FMNL2,FOXO3,GNA13,HSD17B12,IKBKE,INPP5D,LCLAT1,LPL,MAF,MET,METTL7A,MOSPD2,MSI2,MYO10,PIK3R1,PLXND1,POLE3,POLE4,PPP5C,PRAF2,PRKCI,PTGS2,PTPRJ,RAB23,RHOA,SERPINE1,SLA,SOCS1,TBCA,TM6SF1,TNFRSF10A,TRAM1,TWF1,WEE1 | 1099 (16) |
| LY379196 | NA | chemical drug | NA | 1.96e+00 | bias | 0.0e+00 | EGR1,LPL,MSR1,TGFB1 | 1180 (14) |
| DYSF | 1.20e-01 | other | NA | 1.96e+00 | NA | 0.0e+00 | ABCA1,ABRACL,ACTG1,AGPAT2,ANKRD1,ANXA1,ANXA2,APBA3,B2M,CAV1,Ccl7,CD48,CD53,CD74,CD83,CORO1C,CTSH,CTSS,CXCL10,CYBA,DNAJB1,ERRFI1,EVI2A,FCGR2B,FN1,FTL,GABARAPL1,GDF11,GNAI3,GPAT3,GPR65,HLA-A,HLA-DQA1,HSPA1A/HSPA1B,IDH3A,IFI16,ITGB3,LCP1,MRC1,MYOG,PDGFRA,PLIN1,PLPP2,PLPP3,PROS1,PRPF4B,S100A13,S100A4,SREBF1,TCEAL9,TIMP1,TMEM123 | NA |
| PTPN1 | 4.60e-01 | phosphatase | NA | 1.96e+00 | NA | 0.0e+00 | ARID5A,Ccl7,DUSP1,EDEM1,HHEX,IGFALS,IRS1,IRS2,MET,NFKBIA,NOX1,NOX4,PIK3R1,PLAGL1,PRDM16,RILPL1,SMAD7,SOCS1,SREBF1,TMEM26 | 1398 (24) |
| AS1842856 | NA | chemical reagent | NA | 1.96e+00 | NA | 0.0e+00 | ALOX5,BCL2L11,CDKN1A,COL2A1,CXCL10,ESM1,FBXO32,FOXO1,GFPT2,ICAM1,OCLN,PTGS2,RIPK3,TLR4,TRIM63,VCAM1 | NA |
| DES | 3.80e-01 | other | NA | 1.96e+00 | bias | 5.0e-02 | ANKRD1,DCN,SPP1,TGFB1 | NA |
| miR-126a-3p (and other miRNAs w/seed CGUACCG) | NA | mature microRNA | NA | 1.95e+00 | bias | 5.0e-02 | IRS1,SLC45A3,SPRED1,VCAM1 | NA |
| NUPR1 | 2.60e-01 | transcription regulator | NA | 1.95e+00 | NA | 0.0e+00 | ABCC5,ABHD15,ACTA2,ACTR3B,ADRB2,AEN,AKAP12,ANK1,AP5M1,ASB9,ATF3,ATP8B1,AVPI1,B3GAT3,B3GNT5,BCL9,BTG1,BUB1,BUB1B,C3orf62,CACNA2D2,CARMIL1,CCNA2,CDK15,CDK2,CEP170B,CHTF8,CITED2,CNPY4,COL1A1,COL3A1,CREB5,CTPS2,CXADR,CXCR4,DEPTOR,DPH6,DUSP5,E2F8,EGLN1,ELL2,ENO2,ERMP1,ESPL1,ETS1,ETV1,FAM111A,FAM114A1,FAM120B,FAM162A,FCF1,FGF1,FHL2,FOXO3,FUCA1,GADD45A,GBP2,GCH1,GCNT2,GPCPD1,GPSM2,HIVEP3,HLTF,HOXB5,HSPA2,IP6K2,IRF2BP2,IRS2,KAT5,KDM3A,KIF11,KIF18A,KIF23,KLF4,KLF6,KNL1,KXD1,LARS2,LHFPL2,MAGI1,MAN2B2,MAP1LC3B2,MAT2A,MEGF9,MKI67,MYH10,MYO18A,NAA40,NAAA,NEK9,NFIL3,NR1D2,NRROS,PARP9,PCTP,PEA15,PER3,PFKFB3,PFKFB4,PHLDA1,PIK3R1,PLK1,PLK3,PMP22,POLA2,PRAG1,PRELID2,PTPRJ,PXDC1,RAB32,RAB38,RNFT2,RUSC2,S100A4,SAFB,SERF1A/SERF1B,SERPINE1,SHOX2,SHPK,SIX4,SKP2,SLC2A1,SLC39A8,SPC25,SPP1,SPRTN,SRSF1,STX3,SUOX,SYTL2,TANGO6,TESK1,TMEM268,TP53BP2,TRERF1,TRIB1,UAP1,UEVLD,UNC5B,VANGL1,VIM,WDCP,WNK1,ZBTB34,ZC3HAV1,ZFP36L1,ZSWIM6 | 1045 (7) |
| docosahexaenoic acid | NA | chemical drug | NA | 1.95e+00 | NA | 0.0e+00 | ABCA1,ADIPOQ,ARG1,BACH1,BCL2A1,BCL2L1,BDNF,CASP1,CASP8,Ccl2,CD44,CD83,CD86,CDH1,CDKN1A,COL1A1,CSF1,CXCR4,DPYSL2,FADS1,FADS2,FOXO1,FOXO3,FOXP3,GDF10,HDAC7,IL17A,LOX,LOXL1,LOXL2,MMP2,MRC1,MSTN,NFE2L2,NOX4,PDE5A,PIK3R1,PLA2G4A,PLAT,PLTP,PNPLA2,PPARG,PRKG2,PTAFR,PTGES,PTGS2,RXRA,SDC1,SELE,SERPINE1,SERPINH1,SLC2A1,SMAD6,SMAD7,SOCS3,SPHK1,SREBF1,TGFB1,THBS1,THBS2,TIMP1,TNFRSF1B,UCP3,VCAM1 | 1551 (19) |
| rofecoxib | NA | chemical drug | NA | 1.95e+00 | NA | 0.0e+00 | ANGPT2,BCL2L11,MMP2,NCF1,PTGES,PTGS2,TBC1D9,VEGFC | 1357 (18) |
| BMPER | 3.10e-01 | other | NA | 1.95e+00 | NA | 0.0e+00 | ACTA2,ACVR1,ACVRL1,BMP4,CDH1,ICAM1,RUNX2,SOX7,TBX5,VCAM1 | 1225 (18) |
| mir-338 | NA | microRNA | NA | 1.95e+00 | NA | 0.0e+00 | CCND1,CDH1,CDH2,HIF1A,NRP1,RUNX2,VIM | 465 (7) |
| miR-324-5p (miRNAs w/seed GCAUCCC) | NA | mature microRNA | NA | 1.95e+00 | bias | 2.0e-02 | GLI1,LTBP2,RUNX1,SMO | NA |
| bosentan | NA | chemical drug | NA | 1.95e+00 | NA | 4.0e-02 | ACTA2,EDN1,EZR,F3,GATA4,ICAM1,MSN,TGFB1 | NA |
| losartan potassium | NA | chemical drug | NA | 1.95e+00 | NA | 0.0e+00 | ACTA1,Actn3,APLN,ARHGDIB,ATP1A1,ATP2A2,CASP3,CAV1,Ccl2,CD36,COL1A1,COL3A1,CREM,CXCL10,CYBB,EDN1,EGF,EGR1,ENG,F3,FN1,FOXP3,GBP2,GRK5,Ifi47,IGF1,ITGB2,KLF15,MAP2,MMP2,MYH7,NOS1,NOX4,NPR1,OLR1,PLCB1,PRDM16,PTGS2,PYGM,SERPINE1,SOCS3,SPP1,STAR,TEK,TGFB1,TIMP1,TMEM26,TNNC2,TNNI2,VCAM1 | 1333 (18) |
| MIR101 | NA | group | NA | 1.95e+00 | NA | 1.0e-02 | DUSP1,EZH2,IGF1,MET,MITF,OGT,PTGS2,STMN1 | NA |
| miR-673-5p (and other miRNAs w/seed UCACAGC) | NA | mature microRNA | NA | 1.95e+00 | bias | 2.0e-02 | EGR2,Mbp,MPZ,PMP22 | NA |
| Mir200 | NA | group | NA | 1.95e+00 | NA | 0.0e+00 | AP1S2,CFL2,COL1A1,COL3A1,EZH2,LOX,LOXL2,SEC23A,SERPINH1,ZEB2 | 1012 (7) |
| SIRT6 | 5.70e-01 | enzyme | NA | 1.94e+00 | NA | 0.0e+00 | AACS,ACSL3,ACTA2,ADGRE1,ANKRD1,BIRC3,Ccl2,COL1A1,COL3A1,CSF1,DBP,ELOVL1,FN1,IGF1,IL1RL1,IRAK3,IRS2,LSS,LYPLA1,MAPK3,NMNAT1,PC,PLCB1,PLPP3,PTGS2,RPL23,RPL6,RPS15A,SERPINE1,SREBF1,TGFB1 | 1582 (22) |
| Nppb | NA | other | NA | 1.94e+00 | bias | 0.0e+00 | ACTC1,COL1A1,CSRP3,GATA4,GNB3,GNG2,MYBPC3,MYH7,MYL3,PIK3C2G,RND3,RPS6KB1,Tpm1 | NA |
| NCOR2 | 8.50e-01 | transcription regulator | NA | 1.94e+00 | NA | 1.0e-02 | ADIPOQ,AXIN2,BIRC3,C3,CCND1,CDKN1A,CTSS,DIO1,IGF1,LPL,MMP2,NFAM1,PDGFB,PLA2G2A,PLIN1,PTGS2,RARA,STAR | NA |
| miR-292b-5p (and other miRNAs w/seed CUCAAAA) | NA | mature microRNA | NA | 1.94e+00 | bias | 2.0e-02 | BCL11A,BCL11B,BTG1,CSDE1 | NA |
| miR-144-3p (miRNAs w/seed ACAGUAU) | NA | mature microRNA | NA | 1.94e+00 | bias | 2.0e-02 | ADAM10,ADAMTS5,CCND2,E2F2,LGR5,RHOA,ROCK1,TP63 | NA |
| KT5823 | NA | chemical - kinase inhibitor | NA | 1.94e+00 | NA | 4.0e-02 | ACTA2,CNN1,EDN1,S100A10,SLC12A4,SLC2A1,TAGLN2 | NA |
| leucine | NA | chemical - endogenous mammalian | NA | 1.94e+00 | NA | 0.0e+00 | ASNS,ATF3,BTG1,Ccl2,CD36,CDKN1A,EEF1A1,HERPUD1,LEPR,NR4A1,RPS6KB1,SREBF1,UCP3 | 1316 (24) |
| tranilast | NA | chemical drug | NA | 1.94e+00 | NA | 5.0e-02 | CD86,CDH1,CDK2,CDKN1A,NRP1,TGFB1,VCAM1 | NA |
| DKK4 | 4.70e-01 | other | NA | 1.94e+00 | bias | 5.0e-02 | AXIN2,FZD6,MMP2,NKD1 | NA |
| mir-379 | NA | microRNA | NA | 1.93e+00 | NA | 5.0e-02 | CDH1,CDH2,HIF1A,SNAI2,SPRY4,TWIST1 | NA |
| USP38 | 5.70e-01 | peptidase | NA | 1.93e+00 | NA | 2.3e-01 | ACTA2,FN1,IL1RL1,TIMP1 | NA |
| CASZ1 | 4.70e-01 | enzyme | NA | 1.93e+00 | NA | 0.0e+00 | ACTA1,CACNA1D,CKM,COL2A1,EDN1,GRIN3A,HTR1B,ITGA10,KCNK3,MYH3,MYOF,MYOZ1,NEFL,TNFRSF1B,TNNI2,TNNT1,TP63,XYLT1 | NA |
| DICER1 | 2.00e-02 | enzyme | NA | 1.93e+00 | NA | 0.0e+00 | ACVR1C,ANGPT2,ANPEP,APOD,ARID3B,AXIN2,BCL2L11,BDNF,CAMK2A,CAMK2D,CASP3,CCND1,CCND2,CD226,CD44,CD86,CDH1,CDKN1A,CELF2,CHD7,COL18A1,CRYM,CXCL10,CXCR4,EGR1,EGR2,EGR3,ENG,ENTPD1,EPHA3,EYA1,FGF10,FOXP3,GNG2,GZMB,ICAM1,IL18R1,IL2RA,IRF8,ITGA2,ITGA4,ITGA5,ITGA6,KDR,LCP1,LGR5,LIPG,MAF,MAG,MAP2,MICB,mir-133,mir-143,MITF,MRGPRX3,MYH7,OPTN,PANK3,PBX3,PELI2,PIK3CG,PITX2,PMP22,PRKCD,PRKCQ,PRKD1,PROS1,RASGRP1,RET,RGCC,RUNX1,SBDS,SEMA3C,SERPINE1,SERPINF1,SERTAD4,SFRP4,SFRP5,SLC4A4,SOCS3,SPARC,SPN,STAT1,TEK,TGFB1,THBS1,TM4SF1,TNNT1,Tpm1,TPO,TRPC3,TRPC6,TSHR,VIM,WNT4,WNT5A,ZC3HAV1L,ZEB2 | 1592 (21) |
| luteolin | NA | chemical drug | NA | 1.93e+00 | NA | 8.0e-02 | BCL2L1,CASP3,CCND1,CDH1,CDK6,CXCL10,GCLC,ICAM1,IRS1,MMP2,NR2F2,PTGS2,SELE,TLR4 | NA |
| RNF187 | 9.00e-02 | enzyme | NA | 1.92e+00 | bias | 0.0e+00 | AEN,AHR,ATF3,BHLHE40,BTG2,CASP8,CCND1,CDKN1A,CXXC4,CYP1B1,EDA2R,IER5,IGFBP5,IRF1,KLF4,LMO2,LTBP2,MOV10,PCBP4,SH2B1,STAT1,WHRN,ZFP36,ZFP36L1 | 1231 (11) |
| SLPI | NA | other | NA | 1.92e+00 | NA | 4.0e-02 | CCND1,CD86,CTSS,ICAM1,LOX,NFKBIA,NFKBIB,TGFB1 | NA |
| infliximab | NA | biologic drug | NA | 1.91e+00 | NA | 0.0e+00 | ACTA2,ADAM19,BATF,Ccl2,CCND2,CDH2,DDIT4,EDN1,FCGR2B,G0S2,GZMB,IL2RA,INHBA,MAPK14,NFKBIA,PTGES,PTGS2,SLAMF1,SPHK1,TNFRSF25,TNFRSF4,VIM,WEE1 | 1255 (18) |
| GAS2L3 | -2.56e+00 | other | NA | 1.91e+00 | bias | 0.0e+00 | BTG2,CCND2,CDKN1A,EPHX1,F2R,PLK2,SLC19A2,TM4SF1 | NA |
| TNFAIP8 | -7.70e-01 | other | NA | 1.91e+00 | NA | 0.0e+00 | ANKRD1,CENPF,DDAH1,DLC1,DUSP1,IL17A,MDFIC,TNNT2 | NA |
| FBXW7 | -5.50e-01 | enzyme | NA | 1.91e+00 | NA | 1.0e-02 | ADAM17,BCL2L11,CARD11,CD36,CEBPD,COL1A1,CREB3L1,DNAJA1,DTX1,GPAM,HLA-DRA,HSPE1,IDH1,KLF5,ME2,MTHFD2,NFKBIA,NOTCH4,PPARG,SERPINE1,SREBF1,TGFB1,TLR4 | 1598 (20) |
| sitagliptin | NA | chemical drug | NA | 1.91e+00 | NA | 6.0e-02 | ACTA2,Ccl2,COL3A1,COL5A1,CXCL12,FN1,TGFB1 | NA |
| CHRNA7 | -7.10e-01 | transmembrane receptor | NA | 1.91e+00 | NA | 3.6e-01 | Ccl2,CDKN1A,CXCL10,FGF10,IL1RN,PPARD,TGFB1 | NA |
| DNMT3B | -1.20e-01 | enzyme | NA | 1.91e+00 | NA | 0.0e+00 | ACTA1,ACTC1,ATP2A2,CAMK2A,CASQ2,CD36,CDH1,CDKN1A,CKM,CMTM5,CNR1,CYP1B1,DLC1,DNAJB1,ELF4,EMILIN2,ESRP2,EZH2,FGF2,FOXP3,GATA4,GLT8D2,HDAC9,HTR2A,IFIT1,IRF5,KCNA1,KDELR3,KDR,KIT,LONRF1,MAPK4,MAPRE3,MGST1,MID1,MYH14,MYH6,MYH7,MYH7B,MYL2,MYL3,NFATC3,PDE1C,PIK3C2B,PNPLA3,PPM1J,PPP1R1A,PPP1R3A,PPP1R3C,PRKCB,PRUNE2,PTN,RCAN2,RECK,RGS4,SAFB,SAT2,SERPINB9,SFRP2,SFRP4,SFRP5,SLC16A2,ST14,STAT1,TNNC1,TNNI1,TNNT1,TNNT2,TRPC3,WNT10B | 1388 (17) |
| DEPTOR | 7.90e-01 | other | NA | 1.91e+00 | NA | 0.0e+00 | CDH1,CDH2,CX3CL1,CXCL10,ICAM1,SNAI1,VCAM1,VIM | 1332 (17) |
| TCF7L1 | -2.50e-01 | transcription regulator | NA | 1.91e+00 | NA | 5.0e-02 | ARHGDIB,ATF3,AXIN2,CCND2,ESRRB,JAM2,KIT,KLF4,LAMA3,NR2F2,NR5A2,PCSK1N,PPARG,TBX3,TFCP2L1,TNFRSF19 | NA |
| UM101 | NA | chemical drug | NA | 1.90e+00 | bias | 2.0e-02 | CD200,CXCL10,ELOVL7,GBP4,GPR88,HAS3,PLA1A,PRRG4,SLC15A3,TNFSF8 | NA |
| ZNF281 | -6.50e-01 | transcription regulator | NA | 1.90e+00 | NA | 8.0e-02 | CCL24,Ccl6,CXCR4,FANCA,FOXP3,GADD45A,GADD45G,HOXB5,LGR5,PROM1,PTGS2,TNFSF8 | NA |
| JAG2 | -2.60e-01 | growth factor | NA | 1.90e+00 | NA | 1.0e-01 | BCL6,C3,CCL24,CCR1,IL10RA,IL1R1,IL1RN,JAG1,LTB4R,SPP1 | NA |
| CIC | 3.80e-01 | transcription regulator | NA | 1.89e+00 | bias | 0.0e+00 | CCND1,ETV1,ETV5,ITGA2,MAFF,SLC20A1,SPRED2,SPRY4 | 200 (3) |
| ulixertinib | NA | chemical drug | NA | 1.89e+00 | NA | 0.0e+00 | ABCA1,AHR,COL12A1,COL18A1,COL1A1,COL3A1,TNFRSF11B | 922 (7) |
| 10-nitrooleate | NA | chemical - endogenous mammalian | NA | 1.89e+00 | NA | 1.0e-02 | Ccl2,ICAM1,NOX4,PPARG,PTGS2,SELE,VCAM1 | NA |
| MYT1 | NA | transcription regulator | NA | 1.89e+00 | bias | 3.0e-02 | ARHGDIB,DAPP1,GLT8D2,Milr1,PRKG2,PTPRB,TM4SF1 | NA |
| amiloride | NA | chemical drug | NA | 1.89e+00 | NA | 1.9e-01 | ATP1A1,BCL2L1,PTGS2,SRSF3 | NA |
| tosylphenylalanyl chloromethyl ketone | NA | chemical - protease inhibitor | NA | 1.88e+00 | NA | 0.0e+00 | BIRC3,GCLC,GZMB,HAX1,ICAM1,MMP2,NFKBIB,PLCG2,PTGS2,SMAD7,VCAM1 | 739 (11) |
| EGR3 | -2.25e+00 | transcription regulator | NA | 1.88e+00 | NA | 0.0e+00 | ABHD5,AHNAK2,AHR,ANKRD55,ARHGAP24,ATF3,B3GALT6,BCL2L1,BCL6,BHLHE40,CDK14,CHST7,CISH,CTSE,CYB5R2,DOK2,DTX1,EMB,GAD1,GALNT7,HEATR5A,HEG1,IL2RA,IL4I1,INHBB,INSC,ITGB3,LGALS1,MAP7,MXRA8,MYO1D,NAB2,NECTIN1,NFIL3,NRP2,PDE4A,PDE8A,PLEKHA8,PLXND1,RARA,RARG,RASAL1,RET,RFLNB,RGL1,RNPEP,S100A4,SCIMP,SLC39A4,SLC4A3,SOCS1,SOCS3,SPECC1,STK3,TBC1D9,TMEM141,ZBTB20,ZEB2 | 1344 (17) |
| INPP5D | -7.70e-01 | phosphatase | NA | 1.88e+00 | NA | 1.0e-02 | ACTA2,ARG1,CCND1,CCND2,CD86,CD93,FLI1,FOXP3,IL2RA,IRAK3,MITF,SELP,SNAI1,TWIST1 | NA |
| levodopa | NA | chemical - endogenous mammalian | NA | 1.86e+00 | NA | 0.0e+00 | ABCA7,ABI1,ACTA2,ADD3,ADGRB2,ADORA2A,AGPAT1,AIF1,AMIGO2,APBA2,ARHGAP4,ARL3,ATP2A2,AXL,BACH1,BANF1,BCL2L1,BICC1,CA12,CACNB2,CASP3,CCND1,CCS,CD200,CDC42EP3,CHAC1,CHRNA4,CHST11,CIART,CIB2,CLIC6,CNR1,CORO2B,COTL1,CRTC1,CRYM,CTNNBIP1,CTSC,CXCL12,CYTH4,DAAM1,DAB1,DBP,DDIT4L,DIXDC1,DLK1,DMTN,DOC2B,DUSP1,DUSP6,EDNRB,EFNA5,EGR2,EIF6,ERLIN1,FAAH,FADD,FAM114A1,FBLN1,FCGRT,Fcrls,FKBP5,FNIP1,FOXO1,Foxp1,FTL,GABARAPL1,GADD45B,GAPDH,GAS7,GDF10,GFAP,GNA13,GNAL,GNAS,GNB5,GPC3,GPD1,GPD2,GRIA2,HCLS1,HDAC7,HLA-A,HNRNPL,HOMER1,HRAS,HS6ST2,HSPB6,HTR1B,HVCN1,IER3,IGFBP5,IL18BP,IL4I1,INPP5F,INSC,IQGAP1,KCNA5,KCNC4,KCNK1,KDM3A,KDM4B,Klf16,KLF6,KLF9,KLHL6,LAMP2,LASP1,LAT2,LDAH,LDB2,LIX1,LPAR4,LRRC1,LRRTM3,LTBP1,MAT2A,MICAL1,MITF,MMP14,MOB3A,MSMO1,MSRB1,MTERF2,MUSK,NAB2,NAV1,NCF4,NEDD4L,NFATC3,NGEF,NRARP,NSG2,NUAK1,Oasl2,OAZ2,OMA1,OPALIN,P2RY6,PALM,PARM1,PENK,PER1,PGM2L1,PGPEP1,PIEZO2,PIK3CG,PIK3R1,PITPNM3,PLCG2,PLEK,PLEKHO2,PLK2,PLPPR5,PPP1R13B,PPTC7,PRKG2,PTGIS,PTPRZ1,PVALB,Rab15,RAB3D,RAB8A,RANBP3L,RAP1GAP,RASGRP1,RASSF5,REEP3,RELL1,RELN,RERG,RFC2,RGS14,RHBDL3,RILPL1,ROBO2,S100A10,S1PR2,SCRN1,SCUBE3,SIAH2,SKP2,SLAMF9,SLC22A17,SLC25A44,SLC29A3,SLC2A1,SLC2A13,SLC38A2,SMIM14,SMPD3,SOBP,SORCS2,Tgoln1,TIAM2,TLE1,TMCC2,TMEM141,TNFRSF19,TRERF1,TRPC3,TTYH1,UAP1L1,UBXN6,UFSP1,UNC119B,VAT1,VAT1L,VTI1B,WDR17,WDR37,WIPF1,ZEB2,ZNF280D,ZNF281,ZNF385B,ZNRF1 | 1084 (13) |
| STEAP3 | -2.00e-02 | transporter | NA | 1.85e+00 | bias | 0.0e+00 | ACER2,ADORA2A,ANXA2,CD44,COL1A1,COL3A1,CYP1B1,ERRFI1,FGF2,FRMD5,GCNT2,ITGA5,ITGB3,KLF15,LOX,MYH7,NEDD9,NR4A3,PIK3R1,PLOD2,RGCC,S100A10,SORBS2,SORBS3,TRPV4 | 931 (7) |
| filgrastim | NA | biologic drug | NA | 1.85e+00 | NA | 0.0e+00 | ACSL1,ACSL3,ADGRG3,ALOX15,ALOX5,ANXA1,ARHGAP24,ATF3,ATP1A1,ATP2B4,ATP9A,B2M,BATF,BCL2L1,BIRC3,BTG2,CARD6,CCR3,CD44,CD48,CD74,CD83,CDC42EP3,CEACAM1,CMTM5,COL27A1,CSF1R,CST7,CXCL10,CXCR4,CYBB,CYP1B1,CYP27A1,CYSLTR1,DACH1,DDAH2,DDHD1,DGKG,DHRS9,DLC1,DPYD,DPYSL3,E2F2,EDARADD,EGR2,EGR3,EMILIN2,EPSTI1,ERLIN1,EXT1,F5,FA2H,FAM111A,FANCA,FCER1G,FCMR,FGL2,FKBP5,FLT3LG,G0S2,GADD45A,GAPDH,GBP5,GNG11,GP1BB,GPR171,GPR183,GPR34,GZMB,HLA-DRA,HLTF,IFI44,IFIT1,IL18R1,IL1R1,IL2RB,IRAK3,IRF2BP2,ISG15,ITGA4,ITGB7,ITPK1,KIT,KLF6,KLF9,KNL1,LDHB,LEF1,LGALS12,LPAR6,LTB4R,LY75,MAFF,MAPK14,MCM7,METTL7A,MLXIP,MME,MS4A6A,MX1,MYO10,NCOR2,NDUFV2,NHS,NLRC4,NLRP3,NMNAT2,NR4A1,NR4A3,OAS3,OASL,P2RY10,PARP14,PDE4D,PDLIM1,PECR,PFKFB3,PHF6,PRKAR2B,PRRG4,PTGS2,RARRES1,RBP7,RNF43,RSAD2,S100A10,S100A4,SAMSN1,SERPING1,SGK1,SIGLEC8,SLC1A3,SLC25A22,SLC45A3,SOCS1,SORD,SORT1,SPECC1,SPP1,SSBP3,STAT1,STK3,SULF2,TLR4,TLR5,TLR8,TNFAIP2,TNFRSF10A,TNFRSF25,TRERF1,TRPM2,TST,VIM,ZBTB20,ZDHHC2,ZFP36L1 | NA |
| mir-135 | NA | microRNA | NA | 1.85e+00 | bias | 0.0e+00 | BTRC,CASP1,Ccl7,CDH1,CDH2,CXCL12,EDN1,HIF1A,HIF1AN,IL1R1,KLF4,MTSS1,RUNX2,SPP1 | NA |
| PRKN | NA | enzyme | NA | 1.85e+00 | NA | 0.0e+00 | ACTA2,AXIN2,CCNA2,CCND1,CDK6,CDKN1A,COX4I1,CXCL12,EGF,FN1,FUBP1,GATA4,GLO1,ICAM1,IGFBP4,IGFBP5,IGFBP6,IL17A,KDR,LEF1,MAOB,MMP14,NOS1,PLK2,PRDX1,SERPINE1,TNFRSF11B,TNFRSF1B | 1416 (17) |
| 2-chloroadenosine | NA | chemical reagent | NA | 1.85e+00 | NA | 4.0e-02 | CCND1,IL17A,MMP2,SKP2,TGFB1,TIMP1 | NA |
| AIM2 | 4.50e-01 | other | NA | 1.84e+00 | NA | 3.0e-02 | CASP1,CSF1,CSF2RB,FCGR2B,HLA-A,ITGB2,ITGB3,STAT1,TLR7,TNFRSF1B,VSIR | NA |
| Y 27632 | NA | chemical drug | NA | 1.84e+00 | NA | 0.0e+00 | ACTA1,ACTA2,ACTG1,ANKRD1,AXL,BMP4,Ccl2,CD44,CDH1,CDKN1A,COL12A1,COL2A1,CXCL10,DPYSL2,HAS2,ICAM1,MMP2,MYOCD,PPARG,Ppp1r12a,PTGS2,RHOA,SERPINE1,SKP2,SOX6,TAGLN,TAGLN2,TGFB1,THBS1,Tpm1,VCAM1,VIM | 1542 (21) |
| NCSTN | 2.00e-02 | peptidase | NA | 1.84e+00 | NA | 1.0e-02 | CD84,CEBPD,CSF1R,CSF2RB,FCER1G,FCGR2B,IRF8,ITGA2B,NCF1,NCF4,PSENEN,VIM | NA |
| H1-2 | NA | other | NA | 1.83e+00 | NA | 1.0e-02 | AXIN2,CCND1,CISH,GADD45A,GAPDH,HSPA1A/HSPA1B,IER3 | 1107 (11) |
| miR-330-5p (and other miRNAs w/seed CUCUGGG) | NA | mature microRNA | NA | 1.83e+00 | bias | 0.0e+00 | BCL2L1,CD47,ETS1,FGR,NFAM1,SMO,ZFHX4 | NA |
| androgen | NA | chemical drug | NA | 1.83e+00 | NA | 0.0e+00 | ADAMTS15,ADI1,APOD,AXIN2,BDNF,BMP4,BTG2,CA12,CA3,CCND1,CD44,COL12A1,CRP,CX3CR1,CXCL13,CXCR4,ENO2,ERBB3,ETS1,FGF10,FGF2,FLNA,FOXO3,GPT2,IGF1,IGFBP5,INHBA,KAT5,KLF5,Mt1,NFKBIA,NR4A1,NTRK2,PARK7,PIK3R1,PRKCB,PTGS2,PTP4A2,PTPRC,RET,RUNX1,RUNX2,SDC1,SDC4,SFRP2,SKP2,SOAT1,SOCS1,STEAP1,TACC2,TMPRSS2,TNFAIP8,TRADD,TWIST1,VAV3,VEGFC,WNT5A | 1462 (21) |
| herbimycin | NA | chemical drug | NA | 1.81e+00 | NA | 0.0e+00 | ARG1,BCL2L1,CCND1,CDH1,CDK6,CXCR4,DUSP1,F2R,ICAM1,IL2RA,IRS1,MMP2,PTGS2,SERPINE1,SIRPA,TAGLN,TNFRSF11B | 1102 (17) |
| fludarabine | NA | chemical drug | NA | 1.80e+00 | NA | 6.0e-02 | CCND1,CDKN1A,CFB,CXCL13,DEK,HIF1A,IL17A,IRF1,STAT1,TNFRSF10A,TNFSF8 | NA |
| BTG2 | -1.53e+00 | transcription regulator | NA | 1.80e+00 | NA | 1.0e-01 | BTG2,CCND1,DIAPH3,IGFBP4,IGFBP6,NCAM1,NOX4,RARA,SERPINE1,TIMP1 | NA |
| SIS3 | NA | chemical reagent | NA | 1.80e+00 | NA | 0.0e+00 | ACTA2,CDH1,COL1A1,COL3A1,ENTPD1,FOXO1,FOXP3,ITGAE,MRC2,NOX4,SNAI1,VIM | 672 (7) |
| AIRE | NA | transcription regulator | NA | 1.80e+00 | NA | 1.2e-01 | BMP4,C1R,CCL21,CCRL2,CSF1,CXCL10,FABP1,FOXP3,HERC6,ICAM1,IFI44,IL18BP,IL4I1,IRF1,MARCKSL1,MMP14,MPZ,NMI,PARP14,PLPP3,TLR2,TLR8,TPH1,VCAM1,VWCE | NA |
| mir-126 | -7.20e-01 | microRNA | NA | 1.79e+00 | NA | 0.0e+00 | CDH1,CXCL12,DLK1,FOXP3,IRS1,KIT,MITF,MYOCD,PLK2,PTPRC,SNAI2,SPRED1,TAGLN2,TWIST1,VCAM1 | 1112 (10) |
| imipramine | NA | chemical drug | NA | 1.79e+00 | NA | 2.0e-01 | BDNF,EGR1,FABP1,GPATCH3,LSS,MAP1LC3B,TAGLN | NA |
| indole-3-carbinol | NA | chemical drug | NA | 1.79e+00 | NA | 1.2e-01 | ANXA1,CCND1,CDK6,CDKN1A,FOXP3,LCP1,NFE2L2,Slco1a4,SPP1 | NA |
| methylprednisolone | NA | chemical drug | NA | 1.77e+00 | NA | 0.0e+00 | A2M,ABI1,ACSL1,ADAM17,AK4,ALDH1A1,ANPEP,ANXA1,ANXA2,ARG1,ARSB,ASNS,ASPA,ATP1A1,ATP1B1,ATP2A2,B2M,BAIAP2,BDH1,BDNF,BTG1,BTK,CACNA1D,Cald1,Calm1 (includes others),CAMK1D,Ccl2,CCND1,CD180,CD22,CD36,CD44,CD74,CD9,CDH1,CDH2,CDH3,CDKN1A,Chn2,CITED2,CLDN3,CNN3,CNP,CREM,CSNK2B,CTSC,CTSH,CTSS,CYBB,DAB2,DAB2IP,DDIT4,DHRS9,DIO1,DUSP1,DUSP6,DYNLL1,EDNRB,ELOVL5,EMP1,EPHX1,F3,FAAH,FBLN5,FBP2,FBXO32,FCGR2B,FGL2,FGR,FN1,Fn3k,FSTL1,G0S2,GADD45A,GATM,GBP2,GCGR,GCH1,GCLC,GDA,GPD1,GRHPR,HACD3,Hnrnpab,HPD,HSD17B12,HSD3B7,HSPA1A/HSPA1B,IDH1,IGF1,IGFALS,IKBKB,IL17A,IL1R1,IL1RL1,IL1RN,IMP3,INPP5D,IRAK3,IRF1,ITGA2,ITGA5,ITGAE,KLF15,KLF9,KLKB1,KRT19,LAD1,LAMA3,LGALS9B,LOX,LPL,LYN,MAOB,MAP1LC3B,MAPK14,Marcks,MAX,MDFIC,MED4,Mt1,MVK,MYO1G,NDUFC1,NFE2L2,NFKBIA,NGEF,NR0B2,NUDT4,OR51E2,PC,PCTP,PDE3B,PDP2,PIK3R1,PIM3,PLA1A,PLAT,PLCG2,PLS3,PPIL3,PRDM1,PTPN6,PTPRC,RAB38,RAB8A,RAPGEF4,REL,RGCC,RGN,RGS2,RND3,SDC1,SDC4,SERPINB9,SERPINE1,SFRP1,SGK1,SH2D4A,SIRPA,SIRT2,SLC12A7,SLC16A1,SLC37A4,SLC4A4,SLC6A13,SLC9A3,SLCO2A1,SMPD3,SORD,SOSTDC1,SPARC,SPTBN2,STAT1,SYK,TC2N,TINAGL1,TLR10,TLR2,TLR4,TLR5,TLR7,TMEM53,TMSB10/TMSB4X,TNK2,TOP2A,Tpm1,TYRO3,UBE2G2,UCP3,UGCG,VCAM1,VIM,ZFP36,ZFP36L1,ZNF180 | 1381 (17) |
| NAB2 | -1.44e+00 | transcription regulator | NA | 1.77e+00 | NA | 0.0e+00 | BCAR1,CDKN1A,F3,FGF2,FN1,HIF1A,ID2,ID4,NAB2,PPARG,RRAD,TGFB1 | 1106 (16) |
| EEF2K | 1.23e+00 | kinase | NA | 1.77e+00 | NA | 0.0e+00 | BCL2L1,CDKN1A,DCN,KLF5,MAP1B,VIM | 697 (7) |
| trientine | NA | chemical drug | NA | 1.77e+00 | NA | 0.0e+00 | COL3A1,FN1,IGF1,IGFBP4,IGFBP5,SERPINE1,TGFB1 | 476 (7) |
| IQGAP2 | -6.90e-01 | other | NA | 1.76e+00 | NA | 0.0e+00 | CCND1,CDH1,CTNNBIP1,IQGAP1,LEF1,NKD1,SFRP1,SFRP2,WNT4,WNT5A | 1085 (7) |
| GPS2 | 5.20e-01 | transcription regulator | NA | 1.76e+00 | NA | 0.0e+00 | ABCA1,ABCG1,BIN1,Ccl2,CCND1,CDK6,CDKN1A,CXCL10,FAM20C,FOXO1,FZD1,HEBP1,IDH1,Kctd12b,MBNL1,MCTP1,NFKBIA,RGL1,SGK1,SLC44A1,SOCS1,TBCC,TRERF1,VCAM1,WIPF1,XYLT1 | 1105 (20) |
| CDK19 | 2.00e-01 | kinase | NA | 1.76e+00 | NA | 0.0e+00 | ACVR1B,AEN,ANKRA2,ATF3,BAIAP2,BTG2,CCND2,CDH1,CDKN1A,DDIT4,DHCR7,DRAM1,EPHX1,ESRRB,FADS2,GADD45A,HRAS,IER5,IP6K2,ITGB4,KLF4,KLF5,LSS,MVD,MVK,NINJ1,PLK2,PLK3,Podxl,RHBDF2,RPL36,RXRA,SDC1,SESN1,SPHK1,TBX3,TFCP2L1,TGFA,TGFB1,ZFP36L1 | 601 (7) |
| bortezomib | NA | chemical drug | NA | 1.76e+00 | NA | 0.0e+00 | ATF3,BCL2A1,BCL2L1,BCL2L11,BIRC3,BPGM,BRCA2,CASP1,CASP8,CAV1,Ccl2,CCND1,CCND2,CDK2,CDKN1A,CDR2,CEBPD,CRYAB,CSF2RA,CSF2RB,CXCL10,CXCL12,CXCL13,CXCR4,DNAJA1,DNAJB1,DNAJB4,EIF2AK3,FANCA,FCMR,FOXO1,GADD45A,GADD45B,GLI1,GPNMB,HIF1A,HSP90AA1,HSPA1A/HSPA1B,HSPE1,ICAM1,IGF1,IL10RB,IL17A,IL2RA,IL33,INHBA,IRF4,IRS1,ITGA4,KIT,KLF9,MAX,MICB,MITF,MX1,MYOCD,NOX4,NSFL1C,PKIB,PRDM1,PSMA6,PSMB5,PSMC1,PSMD13,PTCH1,PTGS2,RSAD2,SDC1,SNCA,SREBF1,TGFB1,TLR7,TLR8,TNFRSF10A,TP53BP2,VCAM1,VIM | 1490 (20) |
| dorsomorphin | NA | chemical - kinase inhibitor | NA | 1.75e+00 | NA | 0.0e+00 | ABHD5,ACTA1,ACTA2,AMHR2,ARG1,BDNF,Ccl2,CDH1,CDH2,COL1A1,COL2A1,CXXC5,EGR1,FABP1,HDAC4,HIF1A,ID2,KDR,MYOG,NKX6-1,NR0B2,PNPLA2,PNPLA3,PPARG,SELENOP,SERPINF1,SNAI1,SREBF1,STAR | 1538 (24) |
| KLF3 | -1.02e+00 | transcription regulator | NA | 1.75e+00 | NA | 0.0e+00 | ACOT11,ANK1,ANXA5,ARHGEF3,ARID5A,BCL3,BLOC1S1,BOLA1,CAMK2D,CARHSP1,CBFB,CCL24,CD1D,CD93,CEP170B,CSF2RA,CTSC,CX3CL1,DUS3L,E2F2,EEF1AKMT1,EIF4E3,ELMO1,EXTL1,FCGRT,GAD1,GCNT1,GLIPR2,GPD2,GPSM1,HYPK,IDH1,IFNLR1,IL16,IL17RA,IL1RN,IL7,ITGB7,JOSD2,KCNK6,KDM3A,KITLG,KLHL6,LILRB3,LMO2,MAP1S,MATK,MGST2,MRPL34,MSN,MYADM,MYO5A,NUDT8,PDLIM1,PI4K2B,PLPP2,POP5,PPM1A,PSMC5,PTP4A2,RAB7A,RELN,RNF166,RYR1,SCIMP,SDC1,SEC24D,SERPINH1,SGK1,SIGIRR,SLC38A9,SLC52A3,SLC6A13,SP140,SPTB,TDRD7,TEK,TES,TJAP1,TMC7,TMOD3,TNFSF8,TP53I13,TRABD,TRIM36,TUBA1A,UGCG,UNC119B,VIM,WSB1,ZC2HC1A,ZEB2,ZNF367 | NA |
| budesonide | NA | chemical drug | NA | 1.74e+00 | NA | 0.0e+00 | ABLIM1,ACTG1,ALOX12,ALOX15,B2M,B4GALT1,BCL2L11,BTG3,C1R,CAPN5,Ccl2,CDK5R1,CDKN1A,CDS1,CGNL1,CNN3,CPA3,CRYAB,CXCL10,CYP2S1,DYNLL1,ECT2,EFNA5,EMP1,FOXP3,FYN,GNAI1,GPT2,GRHL1,HDC,HIF1A,IFITM3,IL1RL2,IL1RN,INPP4B,KLF9,LCP2,LDB2,LOX,LPIN1,LYPLA1,MAF,MAP2K4,MAPK3,MEGF9,MSMO1,NHSL1,NMI,NPAS2,NR5A1,PCSK5,PDLIM1,PEA15,PFKFB3,PHLDA1,PLD1,PRDM1,PRKCQ,PRKD1,PTN,RAB2A,RAP1GAP,RASGEF1B,SAMD5,SAMSN1,SECISBP2L,SNX16,TIPARP,TLR2,TMOD3,TNFAIP6,TP53BP2,TWF1,UACA,USP6NL,WNK1,WNT5A | 1181 (16) |
| pirfenidone | NA | chemical drug | NA | 1.74e+00 | NA | 2.0e-02 | CDH1,CDH2,COL3A1,CX3CR1,FN1,FOXO1,RND3,SNAI1,TGFB1,VIM | NA |
| HNF4A | 4.00e-02 | transcription regulator | NA | 1.74e+00 | NA | 0.0e+00 | ABCB9,ABCC3,ABCG1,ACAD8,ACD,ACO2,ACSL1,ACSS3,ACTA2,ACVR1,ADAT1,ADCY7,ADGRB2,ADPRHL1,ADRB2,AGPAT1,Akr1b7,ALCAM,ALDH1A1,ALDH8A1,ANKRA2,ANPEP,ANXA5,ARFGAP1,ARG1,ASGR2,ASNS,ATOX1,ATP10A,ATP6V1F,AVPI1,AXIN2,B2M,BARD1,BCAR1,BCKDHA,BCL2L1,BCL6,BDH1,BLOC1S1,BLVRB,BMP5,BOLA1,BORCS6,BPGM,BRAP,BTG1,BTRC,C2,C3,C6,CACNA2D2,CAMK2D,CAV1,CCNA2,CCND1,CCNE2,CD1D,CD36,CDC14A,CDC42EP3,CDCA7L,CDH1,CDK2,CDKL3,CDKN1A,CEACAM1,CEBPD,CETN2,CFL2,CHCHD5,CHI3L1,CHP1,CLDN1,CLDN3,CMC2,CMSS1,CNN3,COMMD5,COPS7A,COQ10B,COX14,CP,CRP,CRYZL1,CSK,CTDSPL2,CUX2,CXADR,CYP1B1,CYP27A1,CYP4F2,CYP7B1,DAAM1,DACH1,DAD1,DBP,DDX27,DHX38,DMP1,DNAJB4,DNAJC17,DPH6,DTX3L,DUSP11,DUSP19,DUSP6,E2F5,EBP,EDEM3,EGLN2,EGR1,EHD3,ELMO1,EMX2,ENC1,EPB41L4B,EPHX1,ERI2,ERLIN1,ESYT1,EXO5,EXOSC5,FABP1,FAM107B,FAM117A,FBLIM1,FBXL7,FBXO31,FEN1,FHL1,FHL3,FKBP10,FKBPL,FLNA,FLOT1,FMO2,FN3KRP,FNTB,FOXO1,FRK,FXYD6,FZD1,FZD6,G0S2,G6PD,GAB1,GADD45B,GADD45G,GAPDH,GBE1,GFER,GGCX,GGT6,GHITM,GINS3,GIPC2,GJB2,GNAI3,GOLGA4,GPATCH3,GPKOW,GPR160,GPX7,GRHL1,GRHPR,GRIN2D,GRWD1,GTF3C5,H2AC18/H2AC19,HIF1A,HIF1AN,HIKESHI,HIRIP3,HLA-A,HNRNPC,HNRNPR,HPD,HSD17B4,HSDL2,HSPE1,HYAL3,IER5,IGF1,IL10RA,IL2RB,INHBA,INHBC,INVS,IRF6,ITGA2,ITGA5,ITGA6,ITGA9,ITGAL,JRKL,JTB,KCNJ11,KCNJ12,KHDRBS1,KLF15,KLHDC3,KLHL6,LAD1,LAMC2,LAMTOR2,LAMTOR5,LARS2,LBP,LCMT2,LDAH,LEPR,LGR5,LIMS1,LSM3,LSM4,LSR,MAL2,MAOB,MAP7,MAT2A,MBD4,MCM8,MDH1,MGST1,MGST2,MICU1,MID1,MON1B,MOV10,MPZL2,MRM3,MRPL18,MRPL2,MRPL22,MRPL27,MRPL34,MRPL46,MRPL53,MRPS12,MRPS18B,MRPS23,MSN,MSRB1,Mt1,NAA10,NAA50,NAPA,NCBP2,NDUFA1,NDUFA7,NDUFB3,NDUFV1,NEURL2,NFE2L2,NFKBIL1,NFYA,NIPAL1,NMNAT2,NOD2,NOP16,NOSIP,NOX4,NR0B2,NR2F1,NR2F2,NR5A2,NSA2,NTHL1,NTRK2,NUAK1,NUAK2,NUCB1,NUDT11,NUDT5,NUDT6,NUP62,NXT2,OAS3,OAZ2,OCLN,OSBPL11,OSMR,PAQR5,PARP9,PDIA5,PDK2,PDK4,PDLIM1,PDLIM7,PEX13,PEX16,PEX6,PFKFB4,PGM1,PHKB,PHPT1,PIGN,PIK3R3,PKM,PLA2G2D,PLA2G4A,PLD2,PLEKHA8,PNPLA3,POLE3,POLR1B,POLR3G,POP5,PPARD,PPARG,PPP1R3B,PPP1R3C,PPP5C,PRAF2,PRCP,PRDM1,PRDM16,PRDX5,PRELID2,PRKAB1,PRKAB2,PRKCE,PRKCZ,PROM1,PRR3,PSMB1,PSMB5,PTGFR,PTPN12,PTPN4,PYGL,RAB2A,RAB30,RAB7A,RABAC1,RAP1GAP,RARA,RARG,RASL12,RASSF5,RBBP4,RBL1,RBM28,RBM42,RFC5,RHPN2,RNASE4,RNF152,RNF5,ROCK1,RPL18,RPRD1B,RPS18,RSAD2,RXRA,SAP30BP,SAP30L,SART3,SAT2,SBNO2,SCAND1,SDC1,SEC23A,SEC24D,SELP,SEMA3C,SEMA7A,SERPINB8,SERPINE1,SGK1,SH3BGRL2,SIRT2,SIX2,SKP2,SLC17A5,SLC22A3,SLC2A1,SLC35A5,SLC35D1,SLC37A4,SLC38A1,SLC38A4,SLC39A6,SLC39A9,SLC44A1,SLC7A6OS,Slco1a4,SLIRP,SMC2,SMG9,SNAI2,SNRPA,SNX3,SOX10,SPCS3,SPP1,SREBF1,SRP68,SRSF1,SRSF3,SSBP1,STARD10,STARD7,STAT1,STOML2,STT3A,SUMO2,SYBU,SYMPK,TAGLN2,TBC1D16,TBRG1,TEF,TERF2IP,TFPT,THAP2,THY1,TIMM9,TMEM123,TMEM17,TMEM176A,TMEM176B,TMEM208,TMEM33,TMEM43,TMEM53,TMEM63A,TMOD2,TNC,TNFAIP6,TNFRSF11B,TOX,TRAPPC6A,TRIP6,TRMT112,TRUB2,TTC26,TUBB4A,TUT1,TXNL1,TYMS,UBE2D3,UBE2M,UBQLN2,UFM1,UMPS,USP46,UTP11,UTP23,VAMP5,VEGFC,VEGFD,VPS51,VSNL1,WDCP,WDR46,WDR77,WNT11,WNT4,XPA,XPNPEP2,XPO1,ZBED3,ZBTB11,ZBTB45,ZC2HC1C,ZFP36,ZFP64,ZFYVE19,ZNF189,ZNF281,ZNHIT1,ZNHIT6 | 1781 (23) |
| mir-17 | NA | microRNA | NA | 1.74e+00 | NA | 0.0e+00 | ABCA1,BCL11B,BCL2L11,BIRC3,CCND1,CD36,CDH1,CDKN1A,COL11A1,DAB2,E2F5,FABP1,FGF9,FN1,GCLC,HSF2,IL17A,LEF1,MYLIP,PHF6,PKD2,PSMD13,RUNX1,SNAI1,THBS1,VEGFD,VIM | 1390 (19) |
| GSTO1 | -3.90e-01 | enzyme | NA | 1.73e+00 | NA | 0.0e+00 | ACSL5,AHNAK2,CAMK2D,CD109,CD9,CELSR1,CHAC1,COL16A1,DUSP6,F3,IFIT1,NAV3,NECTIN3,NPTXR,NR4A2,OAS3,OLFML3,PARM1,PARP9,PKIB,SEL1L3,SEMA3A,SLC17A5,SLC2A1,SMAD9,STAT1,TGFA,THBS1,VSNL1,ZFP36L1 | NA |
| GPR37 | 4.90e-01 | G-protein coupled receptor | NA | 1.73e+00 | NA | 4.0e-02 | Ccl2,DHH,GLI2,MAP1LC3A,MAP1LC3B,PTCH1 | NA |
| SHC1 | -5.50e-01 | other | NA | 1.73e+00 | NA | 0.0e+00 | BCL2L1,BCL2L11,Ccl2,CDH2,CDKN1A,CXCL10,CXCL13,DTX1,EGR1,FGD4,FLI1,FTL,GDA,ICAM1,MAGIX,PHLDA1,PLA2G2D,S1PR2,SDC4,SELE,SERPINE1,SHC4,TEK,THBD | 815 (15) |
| Sn50 peptide | NA | chemical toxicant | NA | 1.72e+00 | NA | 1.0e-02 | BCL2A1,BCL2L1,BIRC3,Casp12,Ccl2,CRP,CXCL10,GZMB,ICAM1,KCNC4,LIPG,MMP2,PPARG,PTGS2,SERPINE1,SLC1A3,SNAI1,VCAM1 | NA |
| sapanisertib | NA | chemical drug | NA | 1.72e+00 | NA | 1.0e-02 | CCND1,CCR5,CDH1,HNRNPC,SNAI1,SRSF1 | NA |
| CLOCK | -1.00e-02 | transcription regulator | NA | 1.72e+00 | NA | 0.0e+00 | AHNAK2,AK4,ARHGEF10,ARHGEF28,ARNT2,BHLHE40,CBFB,CCND1,CD7,CD86,CHST3,CHTF8,CTPS2,DBP,EEF2K,EFHC1,ESYT1,F2R,FAM107A,FGF1,FKBP5,FZD6,GADD45A,GADD45B,GIMAP4,HACD2,HAS2,HSD17B8,HSF2,ICAM1,IGFBP5,IKBKE,IL18BP,ITM2C,KAT5,KCTD1,LIX1,LPIN1,LYPD6,MAPK4,MGAT2,MOXD1,MSMO1,NADK2,NFIL3,NPAS2,NR0B2,NR1D2,OAS3,PDP2,PER1,PER3,POMGNT1,PTAFR,SEC23A,SLC20A1,Smim11,TEF,THBD,THBS1,TMED3,TMTC3,TPST1,TRIL,UHMK1,VSTM4,WEE1,WNK1,WWC3 | 761 (9) |
| 1,1-bis(3’-indolyl)-1-(4-hydroxyphenyl)methane | NA | chemical reagent | NA | 1.72e+00 | NA | 1.0e-02 | ACTA1,CDH2,COL1A1,FN1,NR4A1,SNAI1,SNAI2 | NA |
| PDCD4 | -2.50e-01 | other | NA | 1.72e+00 | NA | 3.0e-02 | CASP3,CDH1,LOX,MAP4K1,PTGS2,SNAI1,VEGFC | NA |
| NME1 | 4.90e-01 | kinase | NA | 1.72e+00 | NA | 0.0e+00 | BOP1,CCND1,CDKN1A,CSTF1,FZD1,L1CAM,LPAR1,MET,MMP14,MMP2,PTGS2,PTN,SERPINE1,SMAD7,SMO,TIMP1 | 1337 (18) |
| miR-451a (and other miRNAs w/seed AACCGUU) | NA | mature microRNA | NA | 1.72e+00 | bias | 1.0e-02 | ADAM10,ADAMTS5,AKTIP,CCND1,FBXO33,MMP2 | NA |
| tofacitinib | NA | chemical drug | NA | 1.71e+00 | bias | 2.0e-02 | CCND1,CISH,CXCL10,DNASE1L3,IL17A,ISG15,JAK3,SOCS1,SOCS3 | NA |
| HMOX1 | -2.60e-01 | enzyme | NA | 1.70e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACTA2,ADIPOQ,ADORA2A,ANGPT2,BCL2L1,BDNF,CASP3,Ccl2,CCND1,CDK2,CDK6,CDKN1A,CNMD,COL1A1,CXCL10,CXCL12,ENG,FGF1,FOXP3,G6PD,GCLC,GPX3,HGF,ICAM1,IGF1,IL17A,IL1RN,ITGB3,KDR,MAP1LC3B,MAPK14,mir-133,MRC1,MSR1,MYH6,MYOG,NCF1,NFE2L2,NR4A2,PITX3,PTGS2,RELN,SELE,SPARC,TEK,TGFB1,THBD,THBS1,THBS2,VCAM1,VEGFD,ZFP36 | 1473 (20) |
| PROC | 1.00e-01 | peptidase | NA | 1.70e+00 | NA | 0.0e+00 | ANGPT2,BCL2A1,Ccl2,F5,HK1,ICAM1,MMP2,NR4A1,PLA2G2A,SELE,SERPINE1,TEK,THBD,THBS1,TLR2,TLR4,VCAM1 | 1253 (17) |
| SATB2 | -4.30e-01 | transcription regulator | NA | 1.70e+00 | NA | 0.0e+00 | ADGRG6,AUTS2,BCL11B,BHLHE22,CDH3,CDH6,CX3CL1,CXCL10,E2F5,FLVCR2,IFI44,ITGA8,LIMA1,MRPL41,NNMT,NOX4,PIEZO2,SDC2,SPP1,TNFSF8 | NA |
| STAR | 9.60e-01 | transporter | NA | 1.70e+00 | NA | 1.0e-02 | ABCA1,ABCG1,CASP1,CASP3,CD36,CD86,CHRNA4,CKM,COX6A2,FGF2,IFITM3,MAOB,MYOF,NUAK1,OGT,PIK3R1,PSENEN,SLC25A33,SPP1 | 483 (7) |
| ruxolitinib | NA | chemical drug | NA | 1.69e+00 | NA | 0.0e+00 | BCL2L1,BTK,CASP1,CCND1,CD44,CISH,COL1A1,COX4I1,COX6B1,CXCL10,CXCL13,DHRS9,ERFE,IL17A,LOXL1,MAP1LC3B,MSR1,NEIL1,NLRP3,PRDX4,PRDX5,PTGS2,PYCARD,SLAMF1 | 862 (19) |
| ADM | 3.60e-01 | other | NA | 1.68e+00 | NA | 0.0e+00 | CALCR,CASP8,Ccl2,EDN1,FGF2,FN1,HIF1A,HRAS,ICAM1,MAX,NOS1,PENK,PGK1,PPARG,PTGS2,SMAD7,SPP1,TGFB1,TNFRSF11B,VCAM1 | 1069 (17) |
| NS-398 | NA | chemical reagent | NA | 1.68e+00 | NA | 0.0e+00 | ALOX15,ANGPT2,ARG1,ATP6AP2,BCL2L11,BTG2,CASP3,CCND1,CD86,CDKN1A,CXCR4,EGR2,F2R,F3,FGF2,HGF,HIF1A,ICAM1,IGF1,IL2RA,MAGI1,MMP14,MMP2,PCDH7,PPARG,PRDX1,PSMB5,PTGES,PTGS2,RECK,RUNX2,SPP1,STAR,TFPI2,WNT10B | 1291 (18) |
| FDI6 | NA | chemical reagent | NA | 1.67e+00 | bias | 0.0e+00 | BRCA2,CCNA2,CCND1,CCNE2,CDC25B,CDK2,CDK6,E2F2,PLK1 | NA |
| kawain | NA | chemical - endogenous non-mammalian | NA | 1.67e+00 | NA | 4.0e-02 | ADIPOQ,Ccl2,NLRP3,NOD2,PPARG,TLR2,TLR4 | NA |
| MXI1 | -1.00e-01 | transcription regulator | NA | 1.67e+00 | NA | 3.0e-02 | ID2,IRS2,MKI67,MTHFD2,MYCN,SLC1A4,SLC7A1 | NA |
| GDF15 | -7.80e-01 | growth factor | NA | 1.67e+00 | NA | 4.0e-02 | CCND1,CDKN1A,LTBP1,MYH7,PNPLA2,RHOA,RND3,SERPINE1 | NA |
| TAF4 | NA | transcription regulator | NA | 1.67e+00 | NA | 0.0e+00 | ABI1,BCL2L1,BCL6,BDNF,CARMIL1,CCND1,CDH1,CDH11,CDH3,CLDN1,COL6A3,DCN,E2F2,ETS1,FMOD,GAS2,GJB2,GREM1,HOPX,ID2,IL1RN,ITGA6,KLF4,KLF5,LUM,MAFF,MAP3K6,MMP2,OLFML3,PDGFC,PENK,PTN,RUNX1,SCUBE1,SFRP2,SPP1,TAF10,Tchh,TGFB1,THBS1,THBS2,VAV3,VEGFC,VEGFD,WNT9A | 1316 (19) |
| UBA1 | 2.00e-01 | enzyme | NA | 1.67e+00 | NA | 1.0e-02 | ANXA2,ANXA5,BIRC3,CCND1,NEFL,NOS1,TAGLN,TAGLN2,VIM | NA |
| BAHCC1 | -1.70e-01 | other | NA | 1.67e+00 | bias | 2.0e-02 | CDKN1A,FZD4,IGFBP4,KLF3,KLF9,PTCH1,SHOX2,SIX4,SMAD7 | NA |
| CLU | 4.30e-01 | other | NA | 1.67e+00 | NA | 1.0e-02 | BCL2L1,CCND1,CCND2,CDH1,CDKN1A,CFH,GBP5,GBP7,HSPA1A/HSPA1B,LARS2,MMP2,NFKBIA,NFKBIB,NOX1,PARP14,SREBF1,STAT1 | 1291 (19) |
| PCYT2 | -2.40e-01 | enzyme | NA | 1.66e+00 | bias | 4.0e-02 | ABCA1,ABCG1,CD36,GPAM,PPARG,SREBF1 | NA |
| KLF10 | 9.80e-01 | transcription regulator | NA | 1.66e+00 | NA | 1.0e-02 | CCND1,CDKN1A,FOXP3,ITGAD,PPARG,SERPINE1,SMAD7,TGFB1,TNFSF8 | 1551 (23) |
| NDRG2 | 5.00e-01 | other | NA | 1.66e+00 | NA | 2.0e-02 | CDH1,MITF,MYH7,SLC1A5,SNAI1,VIM | NA |
| HNF1B | NA | transcription regulator | NA | 1.65e+00 | NA | 0.0e+00 | ACVR1,AXIN2,BGN,BHLHE40,CCDC80,CD44,CDH1,CITED2,CLDN1,COL5A1,COL5A2,DUSP1,EXT1,FBLIM1,FN1,FZD1,FZD2,ID4,ITGA3,JAG1,LUM,MET,MMP2,MPZL2,NR5A2,OCLN,PKD2,PMP22,PSTPIP2,PTGIS,RNASE4,S100A4,S100A6,SEMA3C,SERPINH1,SLC26A3,SNAI1,SNAI2,SPARC,ZEB2 | 867 (7) |
| CGS 21680 | NA | chemical reagent | NA | 1.64e+00 | NA | 4.0e-02 | ADORA2A,BDNF,Ccl2,COL3A1,EGR1,EGR3,F3,HIF1A,PTGS2,RGS2,RGS4,SLC9A1 | NA |
| metformin | NA | chemical drug | NA | 1.64e+00 | NA | 0.0e+00 | AATK,ABCA1,ABCG1,ACTA2,ADIPOQ,AHR,ALDOA,AQP7,ARG1,ARRDC3,ATF3,Atp8b5,BAMBI,BCL3,CASP3,CAV1,CCND1,CCND2,CCR3,CDKN1A,CERS4,CRP,CXCL12,CYP1B1,DDIT4,EGLN1,EIF2AK3,ENO3,F3,FN1,GADD45B,GADD45G,GLO1,GPD1,GPNMB,HBA1/HBA2,HIF1A,IFI44,Ifi47,IGF1,IL17A,IL1R1,IL1RN,INHBA,IRS1,ITGA6,ITGB4,LCAT,MSTN,MX1,MYOD1,MYOG,NFE2L2,NFKBIA,NR0B2,NR4A1,PARP14,PAX3,PEA15,PGAM2,PHKG1,PKM,PLAGL1,PPARGC1B,PPP1R3B,PTGS2,PYGM,RETN,RTN4RL1,RUNX2,SELENOP,SERPINE1,SERPINF1,SLC2A1,SOCS3,SORT1,SPRED1,SPRED2,SREBF1,STAR,TGFB1,TP63,VWF,ZFYVE19 | 1519 (21) |
| molybdenum disulfide | NA | chemical reagent | NA | 1.64e+00 | NA | 0.0e+00 | ACTA2,ACTG2,CFB,CNN1,COL11A1,COL12A1,COL16A1,COL1A1,COL5A1,COL5A2,COL8A2,CPNE7,CRYAB,CSF2RB,CTSC,CTSK,DMPK,DUSP6,EFHD1,ELN,ESM1,EXTL1,FBN1,FHL1,FN1,FNDC1,FSTL1,GPNMB,GREM1,HAPLN3,HSPB7,IFI44,IFIT1,IGFBP5,ITGA11,L1CAM,LBH,LIMCH1,LIMS2,LMCD1,LMOD1,LRRC17,MGST1,MYH10,NXPH3,PFKFB4,PHLDA1,PLA2G4A,PLTP,PXDN,RARRES1,SCD5,SIRPA,SLC2A1,SORT1,SPARC,SPP1,STEAP1,TEK,TENM2,TFPI2,THBS1,TINAGL1 | NA |
| EIF3E | NA | translation regulator | NA | 1.64e+00 | NA | 0.0e+00 | BCL2L1,CCND1,CD36,CDC34,CMTM7,COL18A1,COL5A1,CORO1C,EIF3C,FARP1,FGF2,SMC2,SNAI1,THBS1,TNC,ZEB2 | 1138 (7) |
| ATG5 | NA | other | NA | 1.63e+00 | NA | 0.0e+00 | ARG1,BCL2L11,BCL2L12,CASP3,CKAP4,CTSC,DAD1,DAPK3,DYNLL1,EVA1A,GAS2,HK1,HLA-A,ICAM1,IFIH1,IKBKE,IRF3,LAMTOR2,LAMTOR5,LGALS1,NFE2L2,PPP2R2B,PRKCD,SELE,SIX1,SLC2A1,SNCA,TNFRSF25,VCAM1 | 1012 (14) |
| HBB | 1.00e-02 | transporter | NA | 1.63e+00 | bias | 0.0e+00 | ALOX5,BCL6,C3,CASP3,Ccl2,CFB,CREB1,CSF1,CXCL10,CYSLTR1,HBA1/HBA2,HIF1A,ICAM1,IFI44,IL17A,IL1R1,IL1RN,IL34,IL7,MAPK14,NFATC3,OASL,PLA2G4A,PTGS2,RIPK2,SERPINE1,STAT1,TGFB1,TLR4,TLR5,TRADD,VCAM1 | 1086 (16) |
| SGO1-AS1 | NA | other | NA | 1.63e+00 | NA | 0.0e+00 | CDH1,CDH2,SNAI1,SNAI2,TGFB1,VIM | 1194 (9) |
| RPL13A | 5.80e-01 | other | NA | 1.63e+00 | bias | 2.0e-02 | Ccl2,CDKN1A,CXCL12,CXCL13,ENG,VWF | NA |
| 5A apoA-I mimetic peptide | NA | chemical reagent | NA | 1.63e+00 | bias | 2.0e-02 | ARG1,CCL24,Ccl7,COL1A1,COL3A1,IL17A | NA |
| Gm15807/Hmgn5 | NA | other | NA | 1.63e+00 | NA | 3.0e-02 | ACTA1,ATP2A1,ATP6AP2,CCL21,CSF2RB,IL4I1,MYL3,Srsf5,TNNC2,TNNI2 | NA |
| POLR2M | 4.30e-01 | other | NA | 1.63e+00 | bias | 0.0e+00 | AEN,BTG2,CCND1,CDKN1A,DDIT4,EDA2R,ENC1,MYOF,PLK2,SULF2,TNFRSF10A,TSKU | NA |
| erismodegib | NA | chemical drug | NA | 1.63e+00 | NA | 0.0e+00 | A2M,BCL2L1,BDKRB2,GLI2,HGF,IGF1,MMP2,MTSS1,PTGER3,SFRP2,SNAI1,TWIST1 | 1414 (18) |
| SMAD7 | -6.20e-01 | transcription regulator | NA | 1.63e+00 | NA | 0.0e+00 | ACTA2,ACVR1,ACVR1B,ADAMTS2,ADH1C,BCL2L11,BGN,BMP5,Ccl2,CCNA2,CDH2,CDKN1A,CDKN2C,CGREF1,CITED2,CKM,COL1A1,COL2A1,COL3A1,COL6A3,CRP,CXCL10,CXCL12,DCN,DEPTOR,EIF4EBP1,FN1,FOXO1,GADD45A,GATA4,HDAC9,ICAM1,ID2,ITGA6,ITGBL1,LTBP2,MATN2,MET,MMP2,NET1,NFKBIA,PITX2,PLAT,PMEPA1,PROM1,SEMA3F,SERPINE1,SMAD7,TAGLN,TGFA,TGFB1,TGFBI,TIMP1 | 1110 (17) |
| ADA | -3.00e-01 | enzyme | NA | 1.62e+00 | NA | 3.0e-02 | Ccl2,CCL24,HIF1A,PDE5A,PLAT,SERPINE1,SPP1,TGFB1,TIMP1 | NA |
| CGA | NA | other | NA | 1.61e+00 | NA | 0.0e+00 | ADAMTS1,BDNF,CCND1,CCR3,CREB3L1,CTNNBIP1,EGR2,ETV5,FHL1,FKBP11,FOXO1,HERPUD1,HOMER2,IKBIP,IRAK2,JAZF1,KIT,KLF9,MMP14,MMP2,NR5A1,PARM1,PDIA4,PPIB,PTGS2,SCX,SFRP4,SFRP5,SGK1,SKP2,STAR,TCEAL5,ZNF385B | 1498 (20) |
| HOXD10 | 3.01e+00 | transcription regulator | NA | 1.61e+00 | NA | 0.0e+00 | CCNA2,CD44,CEACAM1,DAPP1,ERP44,EZR,GCNT1,HEBP1,HOXD10,HOXD9,ICAM1,ITGA3,ITGB4,MAGED2,MAOB,MMP14,NCS1,NUDT5,RAB40B,RSAD2,SERPINE1,ST8SIA2,TGFB1I1,TIMP1,TNFSF8,UBL5 | NA |
| AXIN1 | NA | other | NA | 1.61e+00 | NA | 1.0e-02 | APCDD1,CCND1,CCND2,CSRNP1,ENC1,HRAS,LEF1,PITX2,PPARG | 1526 (19) |
| miR-203a-3p (and other miRNAs w/seed UGAAAUG) | NA | mature microRNA | NA | 1.61e+00 | bias | 1.0e-02 | CDK6,CREB1,EZH2,F2RL1,KLF4,PARK7,RUNX2,SOCS3,TP63,TPD52L1 | NA |
| EP4-D | NA | chemical reagent | NA | 1.61e+00 | NA | 0.0e+00 | ACVR1C,BTK,CARD11,CD226,CD74,CX3CL1,GCLC,HLA-A,IKBKE,IL2RB,IL33,INPP5D,MAP1S,PTPN6,PTPRF,ROBO2,SPN,TLE1,ZBTB16 | NA |
| ZBTB18 | NA | transcription regulator | NA | 1.58e+00 | bias | 0.0e+00 | ADGRE5,ANTXR2,COL5A1,DUSP10,LAMC2,MET,MMP2,PIK3R1,SERPINH1,SIX2,SNAI2,TRIL | 1314 (13) |
| MALAT1 | NA | other | NA | 1.58e+00 | NA | 0.0e+00 | ADIPOQ,BCL2L11,CA3,Ccl2,CDH1,EDN1,FRMD8,ISG15,RETN,SELE,SNAI1,SNAI2,SPTB,TWIST1,VIM | 1440 (20) |
| FOXF2 | NA | transcription regulator | NA | 1.57e+00 | NA | 0.0e+00 | ACTA2,ACTG2,CCND1,CDH1,CDK2,CDK6,CDKN1A,FN1,MYOCD,PDGFB,PDGFRA,TAGLN,VIM,WNT5A | 1131 (17) |
| SAV1 | -2.90e-01 | other | NA | 1.57e+00 | NA | 0.0e+00 | CCND1,CDKN1A,COL1A1,COL3A1,FN1,GPC3,MOB1A,PITX2,SPP1,VIM | 703 (7) |
| DUSP11 | 1.72e+00 | phosphatase | NA | 1.57e+00 | NA | 5.0e-02 | IFI44,ISG15,Oasl2,RSAD2,SLFN13,SNCA,USP18 | NA |
| bromobenzene | NA | chemical toxicant | NA | 1.56e+00 | NA | 0.0e+00 | ABCC3,ACTN4,CDKN1A,CDO1,EGF,GADD45A,GAPDH,GCLC,GSR,Gsta4,HSP90AA1,JUND,MSMO1,Mt1,Mt1m/Mt2A,OXCT1,RPL22,RPL28,RPL35,RPS6KB1,TIMP1,TUBA1A,YWHAQ | NA |
| RCAN1 | NA | other | NA | 1.56e+00 | NA | 0.0e+00 | ACTA1,BDNF,CBFA2T3,CCNA2,CD36,F3,GLI2,ICAM1,MYH2,MYH7,PTGS2,SELE,TAF1C,TGFB1,VCAM1 | 953 (16) |
| CISH | -1.30e+00 | other | NA | 1.56e+00 | NA | 0.0e+00 | BCL2L1,CCRL2,CD101,CISH,CSF1,CSF3R,CXCL10,CYP4F2,DNAJC5,EDN1,FBXO31,HCAR2,HDC,IL2RA,MYCN,NAB2,NCAM1,NR4A3,OLR1,PRDM1,PTGS2,RGCC,SPHK1,SPP1,STAT6,Tcf7,TGFBI | 1085 (15) |
| DCN | -2.08e+00 | other | NA | 1.55e+00 | NA | 0.0e+00 | BGN,CASP3,CASP8,CDH1,CDKN1A,CKM,CXCL10,DUSP1,ENG,FBN1,FGF2,HIF1A,HLA-DQA1,ICAM1,IRS1,KIT,MET,MMP2,MYOG,SDC1,SEMA3A,SERPINE1,TGFB1,THBS1,VCAM1 | 1612 (17) |
| necrostatin-1 | NA | chemical reagent | NA | 1.55e+00 | NA | 0.0e+00 | ARG1,BDNF,Ccl2,GFAP,MAP1LC3A,MLKL,MRC1,RIPK3 | 734 (10) |
| PLX5622 | NA | chemical drug | NA | 1.55e+00 | NA | 0.0e+00 | ABCA9,AIF1,AQP4,ARHGAP45,B2M,C3AR1,CACNA1G,CACNB4,Calm1 (includes others),CAMK2A,CAMK2D,Ccl2,CCL24,Ccl6,Ccl7,CCR1,CCR3,CD200,CD34,CD9,CDKN1A,CELF2,COL8A1,COL8A2,CP,CSF1,CSF2RB,CTSS,CX3CL1,CX3CR1,CXCL10,CXCL12,CXCL13,CXCL16,CXCR5,CYBB,CYTH4,DNM1,FCER1G,Fcrls,FN1,GFAP,GRIA2,GRIN2D,HAP1,HLA-DRA,IL10RA,IL10RB,IL16,IL17A,IL1R1,IL1RN,IL2RB,IL2RG,IL33,IL7,ITGB2,L1CAM,LOXL1,LY86,MAP1A,MMP14,MMP2,MYH10,NCAM1,NCF1,NCKAP1L,NDN,NEFL,NRXN2,NTS,OCLN,OLFML3,P2RY12,PGK1,PGRMC1,PRKAA2,S100B,SCN1A,SERPINF1,SLCO2B1,SMYD1,Sp100,SPARC,SPP1,SPTBN2,STAT1,SYP,TGFB1,TLR2,TLR4,TMEM119,TNFRSF11B,TRPV1,UNC93B1,VSIR | NA |
| EIF4G2 | -3.70e-01 | translation regulator | NA | 1.55e+00 | NA | 0.0e+00 | CCND2,CDKN1A,EGLN1,ESRRB,HIF1A,KLF4,KLF5,KRT19,PLAT,PTGS2,TBX3,TFCP2L1 | 615 (7) |
| GW9662 | NA | chemical reagent | NA | 1.55e+00 | NA | 0.0e+00 | ABCA1,ADIPOQ,CAV1,CD1D,CD36,CD83,CD86,CDKN1A,CEACAM1,CNP,CX3CR1,EGLN1,EGLN2,FABP1,FADS3,FN1,G6PD,GCLC,GPAM,GSR,HGF,HLA-DRA,IL17A,IRS2,KDR,KLF4,MCM7,PEA15,PPARG,PTGES,PTGS2,SDC1,SREBF1,TGFB1,VCAM1 | 1453 (21) |
| lipoxin A4 | NA | chemical - endogenous mammalian | NA | 1.55e+00 | NA | 1.0e-02 | ACTA2,CASP1,Ccl2,CCND1,CCR5,CDKN1A,FN1,ICAM1,IRF5,NLRP3,PTGS2,SELE,SERPINE1,TGFB1,TIMP1 | 1376 (18) |
| DIO3 | 6.70e-01 | enzyme | NA | 1.54e+00 | NA | 0.0e+00 | ABCC8,ADAMTS5,ADCY7,ALDH1A1,ALOX5,ART3,CFH,CTTNBP2,DHH,ELF4,ESYT3,F5,FXYD6,GATA4,GDA,GPC3,HLA-A,HOXD10,IER5,INHBA,IRF8,ITGA4,ITGB2,KCNJ11,KIF18A,KLF9,LZTS1,MAMDC2,MC4R,MEOX2,MSR1,NFAM1,NPR1,NR5A1,PAQR6,PCSK1N,PLK1,PNMT,PYGL,SEL1L3,SEMA7A,SLC27A6,SLC38A3,SLC52A3,TACR3,TEF,TYRO3,VCAM1,WNT6 | 930 (13) |
| grape seed extract | NA | chemical drug | NA | 1.54e+00 | NA | 1.0e-02 | BCL2L1,CCND1,CDK2,CDK6,CDKN1A,CREB1,ENO2,GFAP,MKI67,PTGS2,VIM | NA |
| verteporfin | NA | chemical drug | NA | 1.53e+00 | NA | 0.0e+00 | CDH2,CDKN1A,CLDN1,COL1A1,COL3A1,FN1,GADD45A,IL33,NFKBIA,RANBP1,SNAI1,SNAI2,TGFB1,VIM | 1076 (19) |
| FNIP1 | -1.25e+00 | other | NA | 1.53e+00 | bias | 0.0e+00 | MB,MYH7,TNNC1,TNNI1,TNNT1,ZBTB16 | NA |
| vismodegib | NA | chemical drug | NA | 1.53e+00 | NA | 0.0e+00 | A2M,ADGRE1,BDKRB2,Ccl2,CCL21,GLI1,GLI2,HGF,IGF1,IL33,KLF4,KLF5,MKI67,MTSS1,NFE2L2,NT5C1A,PPARG,PTCH1,PTGER3,SFRP2,TNFRSF10A,TNFRSF11B | 863 (14) |
| KDM2B | -6.80e-01 | enzyme | NA | 1.53e+00 | NA | 1.0e-02 | BDNF,Ccl2,Ccl7,CDKN1A,COL2A1,CX3CL1,CXCL10,EZH2,NSG2,PDGFRA,RIPK3,SFRP2,SOX7 | 1173 (19) |
| 1810019D21Rik | NA | other | NA | 1.53e+00 | NA | 0.0e+00 | ADAMTSL3,AK5,APOBEC1,BDKRB2,CDKN1A,COL8A1,EDA2R,EDN1,ESRP2,F5,HGF,ITGA2,ITGB2,KCNH2,KCNN1,MYCN,NIPAL1,PLA2G7,RTN4R,SNAI2,THBD | NA |
| resatorvid | NA | chemical drug | NA | 1.53e+00 | NA | 0.0e+00 | ALDOA,Ccl2,ICAM1,IKBKB,MYH7,NLRP3,PDPN,PKM,PROX1,PTGS2,SLC2A1,TLR4,TLR7,VCAM1,XPA | 1402 (18) |
| GW3965 | NA | chemical reagent | NA | 1.52e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ABHD5,ADRA2A,APOD,CAV1,Ccl2,Ccl7,CCNA2,CD86,CENPF,CRP,CX3CR1,CXCL10,CYTH1,CYTIP,DHRS9,DUSP1,FADS2,GADD45G,GATM,GNAI1,GNG11,GNG2,HCAR2,IER3,IL1RN,IRF8,KIF23,LPIN1,LPL,MICB,MVD,MYLIP,NFKBIA,NR5A2,PDK4,PKIB,PLIN1,PLTP,PRKAR2B,PRKG2,PTGER3,PTGS2,RARA,SKP2,SOCS3,SREBF1,STAR,TOP2A,TRIB1,UGCG,UHRF1 | 1297 (22) |
| ritonavir | NA | chemical drug | NA | 1.52e+00 | NA | 0.0e+00 | ADIPOQ,AXIN2,BCL2L1,BMP1,CCND2,CD36,CDCA7L,CEP70,CFL1,CRYAB,CTNNAL1,CYP4F2,DHCR7,ECT2,ELAVL1,FADS2,GBP2,GRAP,ICAM1,IKBKE,KITLG,LAMA3,MAOB,MET,MME,MSMO1,MVK,NAGK,PNRC2,PPARG,RGS10,SELE,SLC39A10,SREBF1,STYX,TGIF2,TWF2,USP18,VCAM1 | 1477 (23) |
| NTRK3 | NA | kinase | NA | 1.52e+00 | NA | 0.0e+00 | ACTA1,ATP2A1,BCL2L1,BIRC3,CDKN1A,CKM,EGR2,PMEPA1,PROM1,SERPINE1,TNNC2,TNNI2 | 1299 (21) |
| DAB2IP | 8.20e-01 | other | NA | 1.52e+00 | NA | 0.0e+00 | CD44,CDH1,CDKN1A,EGR1,KIT,VIM | 1342 (19) |
| ezetimibe | NA | chemical drug | NA | 1.51e+00 | NA | 2.0e-02 | ABCA1,ACADL,Ccl2,COL1A1,CYBB,DHCR7,MVD,MVK,NCF2,NCF4,PPARG,SREBF1 | NA |
| memantine | NA | chemical drug | NA | 1.51e+00 | NA | 0.0e+00 | ABI1,ACTN2,ATP2B4,BCL2L1,BCR,BDNF,CACNB4,CAMK2A,CDH2,CNKSR2,CREM,DBN1,DDX6,DLG3,ELAVL1,EPHA4,FLOT1,Fnbp1l,FOXP3,GFAP,GLUL,GNAS,HOMER1,HTR2A,KCNA1,KIF5A,MYO18A,MYO5A,NFKBIA,NOS1,NR4A1,NTRK2,PCDH17,PIK3R1,PRKCE,PTPRZ1,RXRA,SCN2B,SIRPA,SPON1,SYNJ1,TENM2,WNK1 | 1328 (19) |
| mir-150 | NA | microRNA | NA | 1.50e+00 | NA | 1.0e-02 | ACTA2,CXCR4,DKC1,EDN1,FZD4,GZMB,HIF1A,IL2RA,MMP14,NCAM1,PDAP1,SLC2A1,SOCS1,TEK | NA |
| fasudil | NA | chemical drug | NA | 1.50e+00 | NA | 0.0e+00 | ACTA2,ARG1,BCL2L1,CASP3,Ccl2,F3,GFAP,ICAM1,MMP2,MRC1,ROCK1,SLC1A3,TAGLN,TGFB1,TLR4,VCAM1 | 1014 (17) |
| PRDM1 | -1.21e+00 | transcription regulator | NA | 1.50e+00 | NA | 0.0e+00 | ATP9A,AXIN2,BCL11A,BCL2A1,BCL2L11,BCL6,BMP5,BTK,CA9,CASP8,Ccl2,CD1D,CD22,CD44,CD48,CD53,CD74,CD86,CDK6,CEP112,CFH,CHI3L1,CIITA,CLDN1,CRP,CXCR4,CYTH4,DDIT4,ECM1,EGR2,ERAP1,EVA1A,EZH2,F5,FAM102A,FAM167A,FGR,FNDC5,FZD2,GAD1,GBE1,GIMAP7,GPAT3,Gsta4,H2AC18/H2AC19,HCK,HHEX,HLA-A,HLA-DQA1,HLA-DRA,ICAM1,ID2,IFIT1,IFNLR1,IL17A,IRF2BP2,IRF4,IRF8,ITGA4,JAG1,KHDRBS3,LGALS1,LRRN1,MAF,MALL,METTL7A,MTMR11,NFAT5,NLRP3,OAS3,PCDH18,PLA2G4A,PRDM1,PRKDC,PROX1,PTPN6,RASSF2,RELN,RGS18,RSAD2,SLC2A5,SLCO2B1,SMPDL3B,SNAI1,SOX8,ST14,STAT1,STAT6,SWAP70,THEMIS2,TNFAIP6,TNFRSF1B,TRIB1 | 1700 (21) |
| PRDM16 | -9.60e-01 | transcription regulator | NA | 1.49e+00 | NA | 0.0e+00 | CDKN1A,CXCL10,DCN,GADD45G,GBP4,GPX3,HGF,IFI44,MYH7,MYOD1,MYOG,OAS3,RETN,SERPINE1,STAT1 | 967 (17) |
| ILF3 | 4.70e-01 | transcription regulator | NA | 1.48e+00 | NA | 0.0e+00 | ABCA9,ACTG1,ALCAM,ANXA5,AQP7,ATF3,C3AR1,CD86,CD9,CFH,CHI3L1,CHKA,CIITA,COL14A1,CXCL10,DHCR7,EBP,FADS2,FKBP5,FMN1,HLA-DRA,ID2,IL1RN,ISG15,LPL,MVK,PLA2G7,POLR2E,PPARG,SEMA7A,TNC | 884 (10) |
| simvastatin | NA | chemical drug | NA | 1.48e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACP5,ACTA2,ACVR1,ADAMTS1,ADIPOQ,ADRB2,ANGPT2,ANXA1,ARHGEF2,BCL2L1,C5AR1,CACNA1G,CASP3,Ccl2,CCND1,CCND2,CD9,CDH1,CDKN1A,CIITA,COTL1,CRP,CYBB,DDAH1,EDN1,ELAVL1,ENC1,ENTPD1,F2R,F3,FABP1,FADS1,FADS2,FOXP3,GLI1,HBA1/HBA2,HK1,ICAM1,IRF1,ITGAL,ITGB2,ITGB4,KIT,KLF4,LPL,MAP1LC3B,MKI67,MMP2,MYH10,NCF1,NCF2,NFKBIA,NTRK2,OLR1,PLAT,POLG,PTGS2,S100A6,SDC4,SELE,SELP,SERPINE1,SLC16A7,SOAT1,SOCS3,SPP1,STAT1,STAT6,THBD,TIMP1,TLR2,TLR4,TNFRSF11B,Tpm1,TYMS,UNC13A,VCAM1,VIM,VWF,WNT4 | 1148 (17) |
| EIF4EBP1 | 1.64e+00 | translation regulator | NA | 1.47e+00 | NA | 3.0e-02 | ARG1,CCND1,CEBPD,CXCL10,EGR1,HK1,IL1RN,IRF8,MAF,NFIL3,PNPLA2,PPARG,PRKAA2,PTGS2,SLC2A1,SOCS1 | NA |
| phorbol 12,13-dibutyrate | NA | chemical - endogenous non-mammalian | NA | 1.46e+00 | NA | 0.0e+00 | AQP4,BCL2L1,Ccl2,CCND2,CD93,CDKN1A,ITGA2,PRKCB,PRKCD,PRKCE,PTAFR,PTGS2,SERPINE1,SPRY4 | 1027 (15) |
| betamethasone | NA | chemical drug | NA | 1.46e+00 | NA | 3.0e-02 | ASPA,CAV1,FXN,G6PD,GFAP,HIF3A,KDR,SFTPB | NA |
| dipyridamole | NA | chemical drug | NA | 1.46e+00 | NA | 3.0e-02 | BCL2L1,BDNF,IL17A,MMP2,PTGS2,SPP1,TGFB1,TIMP1 | NA |
| S100A6 | -2.14e+00 | transporter | NA | 1.46e+00 | NA | 4.0e-02 | ADAMTS1,ATF3,CDH1,DEPDC1,DHRS9,INHBA,RDH5,SELE,TYMS | NA |
| methyl-beta-cyclodextrin | NA | chemical drug | NA | 1.46e+00 | NA | 0.0e+00 | BCL2L1,CAV1,Ccl7,CCND1,HAS2,HIF1A,PLA2G2A,PPARG,SELE,SELP,SERPINE1,TNFRSF8,VCAM1 | 810 (15) |
| PNPLA2 | 7.10e-01 | enzyme | NA | 1.46e+00 | NA | 0.0e+00 | ACADL,ACADS,ACO2,ACSL1,ADGRE1,AGPAT2,ARG1,Ccl2,CD36,COL1A1,ICAM1,IRS1,LPL,MRC1,MSR1,PDK4,PLIN3,PNPLA2,PPARG,PPARGC1B,SLC16A1,SLC2A1,SREBF1,TGFB1,TRIM63,UCP3 | 1322 (21) |
| NR1H2 | 2.20e-01 | ligand-dependent nuclear receptor | NA | 1.46e+00 | NA | 0.0e+00 | ABCA1,ABCG1,C3,Ccl2,Ccl7,CDH1,CRP,CXCL10,CXCL16,GBP4,GLI1,HK1,HSD17B4,IL1RN,ITGAL,LPL,MRC1,MYLIP,NFKBIA,PFKFB1,PLTP,PNPLA2,PRDM16,PTCH1,PTGS2,Scd2,SLC16A2,SREBF1,STAR,TSHR,VEGFC | 985 (21) |
| TP53INP1 | 2.80e-01 | other | NA | 1.46e+00 | NA | 2.0e-02 | CDH1,CDKN1A,SNAI1,SPARC,VIM | NA |
| PPIF | 4.00e-02 | enzyme | NA | 1.45e+00 | NA | 0.0e+00 | ACKR4,ADH7,AMIGO2,Ccl2,Ccl6,Ccl7,CCR1,CCR5,CCRL2,CITED2,CMKLR1,CMTM6,CSRP1,CX3CL1,CX3CR1,CXCL10,CXCL12,CXCR4,DLK1,FEZ1,HCAR1,HGF,IL16,INHBB,IRF5,LRRC8D,MMP2,NDN,PDK4,PDZRN3,PITX2,PTN,SFRP1,SLCO4A1,WNT5A | 1140 (11) |
| Z-551 | NA | chemical reagent | NA | 1.45e+00 | NA | 3.0e-02 | ADGRE1,Ccl2,CD36,LPL,SREBF1,TLR4 | NA |
| NTRK1 | -5.20e-01 | kinase | NA | 1.45e+00 | NA | 1.0e-02 | BCL2L1,BDNF,CDKN1A,EGR1,GADD45A,LGALS1,NR4A1,RET,WNT5A | NA |
| UCN-01 | NA | chemical drug | NA | 1.44e+00 | NA | 2.0e-02 | BCL2L1,BCL2L11,CCND1,CDK2,CDKN1A,ERCC1,PLK1,PRKCQ,XPA | NA |
| mir-122 | -3.00e-02 | microRNA | NA | 1.44e+00 | NA | 0.0e+00 | ADAM10,ADGRB2,ALDOA,BCAT2,CLIC4,CREB1,CSRP1,CUX1,FBLIM1,G6PD,GALNT10,GNPDA2,GNPNAT1,IQGAP1,KHDRBS1,LMNB2,MAP1B,MARK1,MTHFD2,MVK,NUDC,NUMBL,PKM,PLIN3,SLC1A5,SLC7A1,TPD52L2,VAV3,VIM | 439 (7) |
| PAX6 | NA | transcription regulator | NA | 1.44e+00 | NA | 0.0e+00 | ACP5,CCND1,CCND2,CDH6,CDK2,CDK6,CEACAM1,CHKA,CRYAB,CUX2,DKK3,EEF2K,EFCAB14,GAB1,GNG2,HAS2,HOOK2,IQGAP3,Irx3,Klrc2/Klrc3,L1CAM,LAMTOR5,LGALS1,LPCAT1,LRG1,MAF,MAFA,MET,MITF,NAV1,NCAM1,NKX6-1,NTN1,NUMBL,PALM,PAX3,PCNX1,Pcsk1,PCSK1N,POLR2K,RBM12B,SEMA3C,SEMA5A,SMC2,SNCA,SOCS1,SPAG1,STAR,TBC1D9,TMEM252,TNC,WLS,Zfp60 | 525 (7) |
| mir-31 | NA | microRNA | NA | 1.44e+00 | NA | 0.0e+00 | BAMBI,DACT3,EZH2,FGF10,FOXP3,HIF1AN,ITGA2,ITGA5,MET,PRKCE,RDX,RHOA,SPP1,STMN1 | NA |
| GPR39 | -2.30e-01 | G-protein coupled receptor | NA | 1.44e+00 | NA | 0.0e+00 | ANGPT2,DPP4,EDN1,EGF,F3,GLI1,INHBA,PNPLA2,SERPINE1 | 1077 (12) |
| NET1 | 1.05e+00 | other | NA | 1.43e+00 | bias | 0.0e+00 | CDH2,FN1,MMP14,SERPINE1,SNAI2 | 1445 (19) |
| COL4A3 | -2.40e-01 | other | NA | 1.43e+00 | NA | 1.0e-02 | COL1A1,COL3A1,DDR1,FMN1,FN1,ITGA2,ITGB3,MAPK14,MMP14,MMP2,PTGS2,TGFB1,TIMP1 | 1387 (22) |
| perilla alcohol | NA | chemical drug | NA | 1.43e+00 | NA | 2.0e-02 | BCL2A1,CDK2,CDKN1A,NFKBIA,SELP | NA |
| SCD | -4.00e-01 | enzyme | NA | 1.43e+00 | NA | 0.0e+00 | ABCA1,ABHD5,ACADL,ADH1C,ADH7,ADIPOQ,AGPAT2,ALDH1A1,ALDH1A3,ATF3,Ccl2,CD36,CD44,CERS4,CXCL10,CYP1B1,DIO1,EGR1,ELOVL1,ELOVL5,ELOVL7,ENG,FA2H,FADS2,G0S2,GADD45A,GNAT1,GPAM,HERPUD1,IL1RN,KLF4,LEF1,LPIN1,LPL,LRAT,MMP2,MUSK,MVD,PDK4,PNPLA2,PPARD,PPARG,PPARGC1B,PRDM16,RDH10,RDH5,RETN,Scd2,SGPP1,SLC16A2,SLC27A1,SLC2A1,SOCS3,SPP1,SPTLC3,SREBF1,STRA6,TGFA,THBS1,TMEM26,TNC,UCP3,UGCG,VCAM1 | 1353 (22) |
| DLL4 | -9.00e-02 | other | NA | 1.43e+00 | NA | 0.0e+00 | ACTA2,CXCR4,DTX1,EPHB4,ESM1,HEY2,ITGA5,KDR,LGALS1,MAF,MCM7,NR2F2,NRARP,PDGFB,SNCA,Tcf7,UNC5B | 702 (14) |
| HOXA10 | NA | transcription regulator | NA | 1.43e+00 | NA | 0.0e+00 | ACTA1,ADIPOQ,ALDH1A1,B3GALNT1,BCL2L11,CA3,CDKN1A,COL3A1,CSF3R,CYBB,DBP,DHRS9,DPP4,EGR2,EMX2,FCER1G,FN1,FZD1,FZD5,HLA-DQA1,HLF,HNRNPL,HOXA5,HOXD9,HSP90AA1,ID2,IGFBP5,IL1R1,ITGB3,KAT5,KLF10,KLF9,LAMA2,LEPR,MAP1B,MAX,MSN,MYCN,NCAM1,NCF2,NR4A1,PBX3,PDPN,PHGDH,PIK3R1,PRKCD,PROM1,PROS1,PTGER3,REM1,RNASE4,RP2,RPL37A,S100B,Scd2,SFRP4,SLC27A1,SLC27A6,SSPN,ST6GAL1,THBD,WNT10B,WNT4 | NA |
| mir-10 | NA | microRNA | NA | 1.42e+00 | NA | 0.0e+00 | ABCC4,ACVR1C,ALDH1A3,ALOX5,ARG1,BCL2L1,BTRC,CD36,CD44,CD86,CDH1,EDEM1,EPHB2,ERBB3,FKBP5,FLVCR2,FZD5,GLI1,HDAC4,HDC,HIF1A,HOXD10,IL17A,IRF4,KLF4,MAF,NOX4,PRDM1,PROM1,PTPN7,SLC1A5,SMO,SRSF1 | 1471 (17) |
| SOD1 | 3.30e-01 | enzyme | NA | 1.41e+00 | NA | 0.0e+00 | ATP1A1,B2M,BCL2L1,BMP4,BUB1,C5AR1,CACNB4,CASP1,Casp12,CASP3,CCND1,CD36,CDH2,CNR1,COL1A1,CP,CRYAB,CSF1R,DPYSL3,EZR,FAP,FGF10,FGFR1,GCLC,GFAP,GNAS,GNG10,GPX3,GUK1,H2-T24,HDDC3,HIVEP3,HOMER1,ICAM1,IFI16,IFI44,IFIH1,IGF1,INHBA,ISG15,KCNC4,LOC728392,LPL,LRRTM4,MAOB,MET,Mt1,MYBL1,NEFL,NFE2L2,NFIL3,NOS1,OCLN,P2RY6,PAWR,PLA2G4E,PRKCE,PSMB5,PTGS2,RDX,RSAD2,RUNX2,RYR1,SCN1B,SCN2B,SLC38A3,SLFN13,SPP1,STMN1,SYP,TGFB1,TUBB4A,USP18,VCAM1 | 1383 (15) |
| SOD3 | 3.60e-01 | enzyme | NA | 1.41e+00 | bias | 2.0e-02 | CA9,EDN1,EDNRB,HPSE,IL17A,MITF,TGFB1 | NA |
| EOMES | -1.40e-01 | transcription regulator | NA | 1.41e+00 | NA | 0.0e+00 | ACTA2,ACTC1,AFAP1,ALCAM,ANXA1,APLNR,BCL6,BHLHE22,COL3A1,COL6A3,CRYM,CXCR4,CXCR5,FOXC1,FOXP3,FRZB,GNAL,IL2RB,ITGA1,ITGA2,ITGA4,KDR,MEOX1,MICAL2,NEFL,NRP2,PDGFRA,PDPN,PLXNA4,PMP22,PRDM1,PREX1,RGS2,RND3,ROBO2,SV2B,TDRD7,TFPI2,TGFBI | NA |
| FGF21 | -9.60e-01 | growth factor | NA | 1.41e+00 | NA | 0.0e+00 | ADIPOQ,ARG1,ASNS,BDH1,CASP3,CCND1,CDH1,COL1A1,COL3A1,Cox8b,EGR1,FGFR1,IGF1,IRS2,MMP2,MYLIP,PDK4,PHGDH,PPARGC1B,SERPINE1,SLC2A1,SREBF1,TGFB1,VIM | 1472 (20) |
| PTC-209 | NA | chemical reagent | NA | 1.41e+00 | NA | 0.0e+00 | ACTA1,ACTN2,CCDC80,CDKN1A,CGNL1,COBL,COL16A1,COL1A1,COL3A1,COL5A2,CRYAB,ELN,FBLN1,FHOD3,HOPX,IGFBP5,LOXL2,MMP2,MYH6,MYH7,MYL1,PDGFRA,PGAM2,PLOD2,RND1,SORT1,TNFRSF11B,TNNC1,TNNT2 | NA |
| manumycin A | NA | chemical reagent | NA | 1.40e+00 | NA | 2.0e-02 | ANPEP,FN1,PLD1,PTGS2,ST6GAL1 | NA |
| quizartinib | NA | chemical drug | NA | 1.40e+00 | NA | 4.0e-02 | CCND2,DDIT4,FGF2,GADD45G,SPP1 | NA |
| ATF3 | -2.01e+00 | transcription regulator | NA | 1.39e+00 | NA | 2.0e-02 | ADIPOQ,AMPD2,ARF1,ASNS,ATF3,BIRC3,CCND1,CD83,CDK2,CDKN1A,CHAC1,CX3CL1,CXCL16,DCTPP1,GBP2,GBP4,ICAM1,ITGA1,KAT5,KRT19,MMP2,NUDT5,PENK,PHGDH,PLK1,POLA1,POLR1B,PTGES,RIPK2,RSAD2,SELE,SERPINE1,SLC15A3,TLR2 | NA |
| miR-508-3p (miRNAs w/seed GAUUGUA) | NA | mature microRNA | NA | 1.39e+00 | bias | 0.0e+00 | CDH1,SERPINE1,SNAI1,TWIST1,VIM | NA |
| eprosartan | NA | chemical drug | NA | 1.39e+00 | NA | 0.0e+00 | COL1A1,COL3A1,FN1,SERPINE1,TGFB1 | 404 (7) |
| F630028O10Rik | NA | other | NA | 1.39e+00 | NA | 2.0e-02 | Ccl2,COL1A1,MYOG,PTPRC,TGFB1 | NA |
| PEBP4 | NA | other | NA | 1.39e+00 | NA | 2.0e-02 | BCL2L1,CDKN1A,NFKBIA,PTGS2,TLR4 | NA |
| TAPI-1 | NA | chemical - protease inhibitor | NA | 1.39e+00 | bias | 2.0e-02 | Ccl2,LEPR,MMP2,OLR1,VCAM1 | NA |
| docosapentaenoic acid | NA | chemical reagent | NA | 1.39e+00 | NA | 2.0e-02 | Ccl2,CCR5,CD36,IL17A,PTGS2 | NA |
| EIF2S1 | 4.70e-01 | translation regulator | NA | 1.39e+00 | NA | 3.0e-02 | ALDH1L2,CA9,CCND1,CHAC1,DENND2D,GADD45A,GCLC,HHIPL1,HRAS,MAP1LC3B,NNMT,PHLDA1,PLIN4,SLC6A9,SYBU | NA |
| SC144 | NA | chemical reagent | NA | 1.38e+00 | NA | 1.0e-02 | ALDH1A1,CD44,CDH1,CDH2,MMP14,SNAI2,VIM | 960 (12) |
| alefacept | NA | biologic drug | NA | 1.38e+00 | bias | 1.0e-02 | AUTS2,CACNA2D2,CST7,CYBA,FCGR3A/FCGR3B,GZMB,HOPX,IL2RA,IL2RB,MAP2K2,NCAM1,PTPN4,SOCS1,SOCS3,STAT1,STAT6,TGFB1 | NA |
| FBN1 | -8.60e-01 | other | NA | 1.37e+00 | NA | 1.0e-02 | COL3A1,COL6A3,FBN1,INHBA,LTBP1,MMP2,PPARG,RUNX2,SERPINE1 | NA |
| 2-deoxyglucose | NA | chemical drug | NA | 1.37e+00 | NA | 1.0e-02 | BCL2L1,BCL2L11,CASP3,CASP8,Ccl2,CCND1,CD244,CDKN1A,CITED2,CSF1R,DDIT4,GZMB,HIF1A,IRF8,ISG15,LGR5,MAPK14,MYCN,NCAM1,PPARG,PTGS2,SLC2A1,SPP1,STAT1,TAS1R3,TP63 | NA |
| glucocorticoid | NA | chemical drug | NA | 1.36e+00 | NA | 0.0e+00 | ABCC8,ADRB2,AHR,ALOX5,ANXA1,APLN,BCL2L11,BCL3,BDNF,CD44,CD74,CDKN1A,CEBPD,CEP170B,CLEC11A,CLIP2,CNR1,COL1A1,CSF1,CSF1R,CXCL13,CXCR4,DBP,DUSP1,EDN1,FBLN1,FN1,FOXP3,G6PD,GCH1,GLUL,GPX3,GZMB,HAS2,HLA-DOB,HRAS,ICAM1,IL10RA,IL16,IL17A,IL1RN,IL2RA,INPP5D,IRF8,JAK3,KCNJ11,LAT2,LPIN1,LPL,Mt1,NCF1,NCF2,NFKBIA,NOD2,NOS1,NR4A2,OGN,PER1,PER3,PLAT,PNMT,PPARG,PTGS2,SELE,SERPINE1,SFTPB,SGK1,SLC9A3,SOCS3,SPP1,STX11,TGFB1,TLR10,TLR2,TNFRSF11B,UCN,UCN2,VCAM1,ZBTB16 | 1430 (15) |
| FLCN | 1.50e-01 | other | NA | 1.36e+00 | NA | 0.0e+00 | ACKR3,ADAMTS1,ALDOA,APBB1IP,ATP6V1A,ATP6V1E1,BCL2L11,BHLHE40,CEACAM1,CLCN7,COL2A1,COX4I1,Cox8b,CTSC,CXCR4,DUSP5,ECM1,EGF,EGLN1,ENG,Esrra,GPNMB,GULP1,HHEX,HIF1A,ICAM1,KLF4,L1CAM,LAMP2,LCP1,MCOLN1,NDUFV2,PANK3,PITX2,PLXND1,PPARGC1B,PRDM16,SEMA3E,SEMA5A,SERPINE1,SLC17A5,SLC1A1,SLC2A1,SLC36A1,SPARC,TACC2,UAP1L1,UCP3,UQCR10,WLS | 1469 (20) |
| CREM | -6.10e-01 | transcription regulator | NA | 1.36e+00 | NA | 0.0e+00 | ABCA1,ACTC1,ADRB2,ATF3,ATP2A2,BHLHE40,BTG2,CCND1,CCND2,CD86,CIART,COL3A1,COL8A1,CREM,CSRNP1,DUSP1,EGR1,EGR2,ERRFI1,FUT7,GADD45B,GPD2,HLA-DRA,IL17A,INHA,IRS2,KLF5,LSS,MIDN,MSMO1,MVK,NAB2,NFIL3,NOS1,NR4A1,NR4A2,PDP2,PER1,PGK1,SIAH2,SLC16A1,SPATA20,STAR,THBS1,TIPARP,Tpm1,TSHR | 1542 (21) |
| promegestone | NA | chemical drug | NA | 1.35e+00 | NA | 0.0e+00 | ABCC8,BCL2L1,BCL6,BIRC3,BTG2,CCND1,CDKN1A,DUSP5,ENO2,ERBB3,F3,FAM89B,FKBP5,IER3,IL1R1,INHBB,IRS2,LAMC2,NET1,NFKBIA,PDK4,RARG,RGS2,SGK1,STAT1,STAT5B,TIPARP,ZBTB16 | 1427 (21) |
| dichloroacetic acid | NA | chemical drug | NA | 1.35e+00 | NA | 2.0e-02 | ARG1,FOXO3,FOXP3,HIF1A,IL17A,PDK4,Pmaip1,SLC2A1 | NA |
| lipofermata | NA | chemical reagent | NA | 1.35e+00 | NA | 0.0e+00 | ACTA1,ACTA2,ATF3,CASP3,FGF2,FN1,GDF10,LTBP1,PDGFB,PPARG,TGFB1 | NA |
| RO7051790 | NA | chemical drug | NA | 1.35e+00 | NA | 1.0e-02 | ACTA2,CDH1,CDH2,FN1,SNAI1 | 1351 (19) |
| miR-9-5p (and other miRNAs w/seed CUUUGGU) | NA | mature microRNA | NA | 1.34e+00 | bias | 1.0e-02 | ACTA2,ALDH1A3,ALDH9A1,CD44,CDH1,COL1A1,FGF16,FN1,FOXO1,HK1,HSP90AA1,JAK3,NDUFB9,NDUFC1,PFKFB3,PGK1,PKM,PMP22,PRDM1,UQCR11,ZFP36 | 1037 (12) |
| Fibrin | NA | complex | NA | 1.34e+00 | NA | 0.0e+00 | ACTA2,CDH1,CNN1,COL2A1,F3,FN1,GFAP,ICAM1,KDR,MYF5,SERPINE1,TAGLN,TLR4 | 1242 (20) |
| MTO1 | 6.40e-01 | enzyme | NA | 1.34e+00 | NA | 0.0e+00 | CCND1,CDH1,CDH2,MMP2,VIM | NA |
| GCS-100 | NA | chemical drug | NA | 1.34e+00 | NA | 0.0e+00 | BCL2L1,CCND2,CCNE2,CDK6,CDKN1A | 1086 (10) |
| GSTM5 | 2.00e-02 | enzyme | NA | 1.34e+00 | bias | 1.0e-02 | CHST7,EPHX1,Gsta4,MAPK14,PTGES | 963 (7) |
| ERP29 | -1.00e-02 | transporter | NA | 1.34e+00 | NA | 2.0e-02 | OCLN,SNAI1,SNAI2,TWIST1,ZEB2 | NA |
| enoxacin | NA | chemical drug | NA | 1.34e+00 | NA | 2.0e-02 | ATP6V1E1,CALCR,CTSK,ITGB3,LCP1 | NA |
| cobalt | NA | chemical toxicant | NA | 1.34e+00 | NA | 3.0e-02 | FGF2,HIF1A,ICAM1,PFKFB1,PFKFB3,PGK1 | NA |
| clobetasol propionate | NA | chemical drug | NA | 1.34e+00 | NA | 4.0e-02 | CD86,GCLC,ICAM1,IL2RA,LY75 | NA |
| BMS-754807 | NA | chemical drug | NA | 1.34e+00 | NA | 4.0e-02 | CCNA2,ELN,EPHA4,MET,MKI67 | NA |
| JMF3086 | NA | chemical reagent | NA | 1.34e+00 | NA | 4.0e-02 | Ccl2,CCND1,CDH1,PTGS2,VIM | NA |
| TIMP3 | -2.20e-01 | other | NA | 1.33e+00 | NA | 0.0e+00 | ADAM10,BAMBI,BMP4,EGR2,ENG,HRAS,KIT,KLF4,LAMC2,LTBP1,MAPK3,MET,MMP2,SERPINE1,SMAD6,SMAD7,STAT1,TGFB1,THBS1,VIM,WNT11,ZEB2 | 1133 (17) |
| Il3 | NA | cytokine | NA | 1.33e+00 | NA | 0.0e+00 | AATK,ADAM10,ADAM17,ADAM19,ADGRE1,ANPEP,BCL2L1,BCL2L11,BHLHE40,CCND2,CDKN1A,CISH,COL2A1,CSF1,CSF1R,CSF3R,EGR1,HRAS,IGF1,NFIL3,PRKCE,SOCS1,SPP1,TNFRSF1B | 1066 (19) |
| mono-(2-ethylhexyl)phthalate | NA | chemical toxicant | NA | 1.32e+00 | NA | 2.0e-02 | ACADL,ACO2,ACSL1,ADIPOQ,APOBEC1,CCND2,CD36,COX4I1,DDIT4,Esrra,FADS1,FBP2,G6PD,GAPDH,GNPNAT1,GPD1,GPI,IDH3A,IDH3G,IL18BP,IRS2,LPL,MDH1,NDUFB9,NDUFS7,NDUFV1,NDUFV2,NOX1,OLR1,PC,PCOLCE,PDK4,PGAM2,PGK1,PPARD,PPARG,PPARGC1B,PPTC7,TKT | NA |
| CCN3 | NA | growth factor | NA | 1.32e+00 | NA | 0.0e+00 | BMP4,COL1A1,GREM1,ITGA2,MMP2,MYOD1,MYOG,PDGFC,RUNX2,SERPINE1 | 1349 (23) |
| UBE2I | -5.00e-02 | enzyme | NA | 1.32e+00 | NA | 2.0e-02 | CCND1,CEBPD,CXCL10,IRF1,MYLIP,NR0B2,PDK4,PPARG,PRDM16,SGK1,SLC2A1,STAT1 | NA |
| KDM1A | 0.00e+00 | enzyme | NA | 1.32e+00 | NA | 0.0e+00 | A2M,ACTA2,APOBEC1,ARHGDIB,ATF3,B4GALT1,BCL3,BRCA2,C3,C3AR1,Ccl6,CCNA2,CCND2,CD22,CD48,CD74,CD84,CD9,CDH1,CDKN1A,CENPF,CENPK,CFAP126,CIITA,COL1A1,CREBZF,CRYM,CSGALNACT1,CST7,CTSC,CTSS,CXADR,CXCL10,CXCL13,CXCL16,CYBB,DAPP1,DDR2,DOCK2,E2F8,EBF1,ELF4,ELL2,ELOVL7,EPHX1,EPSTI1,FCGR2B,FCGR3A/FCGR3B,FGF10,FGR,FN1,FOXO1,GAP43,GATA4,GBP2,GBP4,GBP5,GFAP,Ggta1,GLT8D2,GPNMB,HAS3,HIF1A,HLA-A,HLA-DQA1,ID2,IFI16,IFI44,IFITM3,IGFBP4,IL1RN,IQGAP2,IRAK3,ISG15,ITGB2,KHDRBS3,LAMA3,LCP1,LGR5,Lrrc74b,LY86,MAP2,MCM8,Milr1,MSN,OASL,Oasl2,OSMR,PARP14,PDPN,PHLDB2,PLIN4,POLE4,PRKG2,PROM1,PTPRB,PTPRC,PTX3,RAB2A,RARG,RBL1,RETN,RNF213,S100A6,SCN1A,SELENOP,SERPINE1,SERPINF2,SFRP1,SFRP2,SFRP4,SFRP5,SIX5,SLAMF9,SLC1A5,SLC22A3,SLC37A2,SLC38A3,SLC7A10,SLFN13,SMAD7,SNAI1,SREBF1,SYBU,THBS1,TLR2,TM4SF1,TMCO4,UHRF1,USP18,VCAM1,VIM,ZBTB20,ZNF367 | 1308 (20) |
| mir-30 | NA | microRNA | NA | 1.31e+00 | NA | 0.0e+00 | ADRA2A,ARID5B,Ccl2,CDKN1A,CHD7,GADD45A,ITGA2,ITGB3,KLF9,MYH7,NEDD4L,PRDM1,RAB38,RUNX2,SERPINE1,SKP2,SNAI1,UGT8,VIM | 1480 (18) |
| propofol | NA | chemical drug | NA | 1.31e+00 | NA | 4.0e-02 | ANXA1,AQP4,BCL2L1,CASP3,CYBB,EGR1,MMP2,NCF1,NET1,THBS1,TLR4,ZFP36 | NA |
| latrunculin B | NA | chemical reagent | NA | 1.31e+00 | NA | 2.0e-02 | ACTA1,ACTA2,CNN1,MYOD1,PFN1,SKP2,TAGLN | NA |
| mir-25 | NA | microRNA | NA | 1.30e+00 | bias | 0.0e+00 | BCL2L11,CDKN1A,E2F2,EDNRB,FGF2,GADD45A,ITGA5,ITGB3,KITLG,MAP2K4,MITF,MYLIP,NOX4,TBX3,TP63 | 1367 (17) |
| fenretinide | NA | chemical drug | NA | 1.30e+00 | NA | 0.0e+00 | ACER2,ANKRD1,ATF3,ATP1B2,BCL2A1,CASP3,CCND1,ENAH,ERCC1,FYN,GZMB,HIF1A,IGF1,IGFBP7,MKI67,NCF2,NFE2L2,NFKBIA,PTGS2,RARG,RXRA,STAT1,XPA,XPO1 | 1228 (15) |
| ANTXR2 | -7.00e-01 | transmembrane receptor | NA | 1.29e+00 | NA | 0.0e+00 | CCND1,CDH1,FN1,HGF,KITLG,MMP2,PPP2R2B,VIM | 1082 (16) |
| NQO1 | -4.10e-01 | enzyme | NA | 1.29e+00 | NA | 0.0e+00 | ALDOA,BCL2L1,BIRC3,C5AR1,Ccl6,CCND1,CCR1,CDKN1A,CSF3R,CXCL12,CXCR4,DOCK2,ENO2,KIT,PKM,PTGS2,SLC1A5,SLC2A1,SLC38A3,VCAM1 | 1189 (15) |
| PAK2 | -5.60e-01 | kinase | NA | 1.29e+00 | NA | 0.0e+00 | BMP4,DUSP1,ETS1,GADD45A,IFI16,IGF1,IGFBP5,NOX4,PRKCI,PROX1,S100A6,SMAD7,SMAD9,TAGLN,ZEB2 | 1346 (16) |
| NLRX1 | 2.70e-01 | other | NA | 1.29e+00 | NA | 1.0e-02 | BIRC3,CASP8,FADD,IKBKB,IL17A,IL1R1,IRF1,MAP3K14,NFKBIA,NFKBIB,PIK3R1,REL,SLC2A1,STAT1,TRADD | NA |
| NNMT | -1.02e+00 | enzyme | NA | 1.29e+00 | NA | 0.0e+00 | ACTA2,COL1A1,FN1,SYP | NA |
| prednisolone | NA | chemical drug | NA | 1.29e+00 | NA | 0.0e+00 | ADORA2A,ARG1,ATG16L2,BCL2L1,BIRC3,BTG1,BYSL,CALCR,CASP3,CASP8,Ccl2,CD86,CDK5R1,CEBPD,CRP,CSNK1D,CTSS,CXCL10,CXCR4,CYGB,DAD1,DAPK1,DLL1,DRAM1,DUSP1,DUSP10,EDN1,EIF2AK3,EVA1A,FADD,FBXO32,FKBP5,FMO2,GAB1,GABARAPL1,GLI1,GM2A,GPX3,HEY2,HIF1A,HSP90AA1,IGF1,IRS2,ITGA4,JAG1,KANSL1L,KLF9,MAP1LC3A,MAP1LC3B,MAPK14,MB,MYCN,NFIL3,NMT2,NOTCH2,NOTCH4,NUDT18,NXN,PARK7,PGK1,PIK3CG,PLAT,PRDX1,PRKAA1,PRKAA2,PTGS2,RHOA,RNF38,RNF7,RPS6KB1,SDC2,SGK1,SLC29A3,SNCA,SOCS1,SPP1,STAT1,TGFB1,TMEM43,TNFRSF11B,TPO,TRIM63,TXNRD3,UCP3,UTRN,ZBTB16,ZFP36L2 | 1801 (19) |
| mir-140 | NA | microRNA | NA | 1.28e+00 | NA | 0.0e+00 | ACTA2,ADAMTS5,CDH1,COL3A1,HDAC4,HIF1A,LEF1,LOX,LOXL2,OGN,PGK1,TGFB1,VIM | 578 (7) |
| NOG | -8.50e-01 | growth factor | NA | 1.28e+00 | NA | 1.0e-02 | BMP4,CXXC5,GFAP,HAS2,ID4,KDR,LEF1,MITF,MYOG,NCAM1,PTCH1,PTGS2,RUNX2,SPP1,VCAN,WNT5A | NA |
| 4-phenylbutyric acid | NA | chemical - endogenous mammalian | NA | 1.28e+00 | NA | 0.0e+00 | ABCA1,ADAM17,ASPA,BCKDHA,CASP3,CASP8,Ccl2,CCND1,CDKN1A,CNP,CXCL12,EDEM1,EIF2AK3,EPHX1,FOXP3,GFER,HIF1A,HLA-A,HOMER1,LGI1,LPAR6,LYPLA1,MC4R,MMP2,MOG,NLRP3,OCLN,OLR1,PARK7,PLP1,PRKCE,PTGS2,ROCK1,SELENOP,SLC16A2,SOCS3 | 1112 (18) |
| PSEN2 | 8.00e-02 | peptidase | NA | 1.28e+00 | NA | 0.0e+00 | ACSL1,ANXA5,ATP2A2,C3AR1,CASP3,CCS,CD74,CD9,COX4I1,CTSC,CTSS,CYTIP,DBP,DLL1,EMP1,F2R,FOXO3,FZD4,GAPDH,GDF11,GFAP,HBA1/HBA2,LHX8,PDGFRA,PRC1,PSENEN,PSTPIP1,PTGS2,PTPRF,SLC38A2,Sp100,THY1,UBC,UEVLD,Zfp101 | 1480 (19) |
| ERFE | 1.78e+00 | other | NA | 1.28e+00 | NA | 2.0e-02 | CD36,FABP1,ID2,RUNX2,SMAD6,SMAD7,TNFRSF11B | NA |
| EIF4EBP2 | -2.90e-01 | translation regulator | NA | 1.27e+00 | NA | 1.0e-02 | ARG1,CEBPD,CXCL10,EGR1,GRIA2,IL1RN,IRF8,NFIL3,PNPLA2,PPARG,PTGS2 | NA |
| tyrphostin AG 1024 | NA | chemical drug | NA | 1.27e+00 | NA | 2.0e-02 | HIF1A,IGF1,NR5A1,PTGS2,RBL1 | NA |
| IL7R | NA | transmembrane receptor | NA | 1.27e+00 | NA | 2.0e-02 | AHR,BAIAP2,DAPK1,DPP4,EBF1,EPHB2,EZH2,FHL2,FOXP3,GAS2,IKZF2,IL17A,IL2RA,IL7,IRF4,MYH10,MYH14,OLAH,PRKCE,SELE,SNAP47,SPON1,Tcf7,UST,VCAM1 | NA |
| troglitazone | NA | chemical drug | NA | 1.27e+00 | NA | 0.0e+00 | AATK,ABCA1,ABCG1,ACADS,ACSL1,ACTA1,ACTA2,ADIPOQ,ANXA2,AQP7,ATF3,AXIN2,BCKDHA,BCL2L1,BIRC3,BMP1,BTRC,C3,Cald1,CAV1,CAV2,Ccl2,CCND1,CCND2,CD34,CD36,CD86,CDCA7L,CDH1,CDK2,CDKN1A,CDKN2C,CEBPD,CEP70,CFL1,CIB2,CIITA,CKM,COL1A1,Cox8b,CREB1,CRYAB,CTNNAL1,CXCL10,DCN,E2F2,ECH1,ECT2,EGR1,ELAVL1,ENO2,ETS1,FADS2,FN1,G0S2,GADD45A,GBP2,GLO1,GPAM,GPD1,HBA1/HBA2,HGF,HLA-DRA,ICAM1,IFI16,IRS1,ITGA6,ITM2A,KLF4,LAMA3,LAMA4,LPL,MAOB,MKI67,MME,MSR1,NAGK,NCF1,NFKBIA,NKX6-1,NNMT,NR2F2,NR4A1,NR4A3,PC,PDE3B,PDGFRA,PDK4,PLIN1,PLIN4,PNRC2,PPARG,PTGES,PTGS2,RETN,RGS10,SDC1,SELE,SERPINE1,SKP2,SLC27A1,SLC2A1,SLC39A10,SLC9A1,SNAI1,SPP1,STYX,TBXAS1,TGFB1,TGIF2,TST,TWF2,UCK1,UCP3,USP18,VCAM1,WEE1 | 1482 (20) |
| FLT1 | NA | kinase | NA | 1.27e+00 | NA | 0.0e+00 | ACTN4,APLNR,BCAT1,Ccl2,CCNI,CDKN1A,CLIC4,COL2A1,FLNA,GSK3A,HK1,ICAM1,LIMS1,MAT2A,MAX,NRP1,NRP2,PREB,RBBP4,RDX,SCRN1,SLC27A3,THBS1,VWF | 1227 (18) |
| raclopride | NA | chemical drug | NA | 1.27e+00 | NA | 3.0e-02 | BDNF,NR4A1,NR4A2,NR4A3 | NA |
| 1,2-dithiol-3-thione | NA | chemical reagent | NA | 1.27e+00 | NA | 0.0e+00 | ABCC3,ACSL5,ACTG1,ALDOA,APBA3,ARF1,ATP1A1,CDC34,COQ7,DAD1,DHCR7,DYNLL1,EIF3C,EIF3G,EIF6,EPHB4,EPHX1,FABP1,FKBP11,FKBP5,GAS2,GBE1,GCLC,GSR,Gsta4,HACD3,HAX1,HSP90AA1,LPL,MRPS18B,MSMO1,NFE2L2,PDIA4,PPIB,PRDX1,PSMA4,PSMA6,PSMB1,PSMB5,PSMC1,PSMD13,RPL18,RPS16,S100A13,SEC23A,SLC16A2,SREBF1,TBRG1,Tpm1,UBQLN2,VCP | 424 (7) |
| RGS2 | -1.76e+00 | enzyme | NA | 1.26e+00 | NA | 0.0e+00 | ARHGEF16,BTG2,C1GALT1,CEBPD,CHMP4B,CXCL12,ERRFI1,EVA1A,F3,FBLIM1,GAPDH,GJA3,Hmgn2 (includes others),ITM2A,LPL,MORC4,NINJ1,PDIA4,PDLIM1,PDLIM4,PLAT,PLVAP,PLXND1,PPARG,PPIB,PSTPIP1,RAB31,RFLNB,SLC16A1,SLC16A3,SLC2A1,SLC35F1,SLC7A8,SLCO4A1,SNX3,SPP1,SREBF1,ST6GAL1,Ubb,UGCG | 1333 (18) |
| SAHM1 | NA | chemical reagent | NA | 1.26e+00 | bias | 0.0e+00 | ABLIM1,BHLHE40,CD44,CFH,DDIT4,DOCK5,DTX1,ELMO1,FLNA,PFKFB3,PPARG,RHOBTB1,RPUSD3,SUSD4,WDR4,ZBED3,ZFP36L2 | NA |
| FABP1 | 9.30e-01 | transporter | NA | 1.26e+00 | NA | 0.0e+00 | ABHD5,ACTA2,CD36,COL1A1,FAAH,PNPLA2,PNPLA3,PPARG,SLC27A1,SREBF1 | 818 (15) |
| calyculin A | NA | chemical toxicant | NA | 1.26e+00 | NA | 1.0e-02 | CCND1,CCND2,CD200R1,CDKN1A,CYP1B1,EGR1,NR2F2,NR4A3,SELP,VWF | 1470 (25) |
| HAVCR2 | -7.60e-01 | other | NA | 1.26e+00 | NA | 4.0e-02 | CASP1,CCR5,CDKN1A,CX3CR1,CXCR4,CXCR5,MKI67,NLRP3,PRDX5,Tcf7 | NA |
| TFAP2C | NA | transcription regulator | NA | 1.26e+00 | NA | 0.0e+00 | ALCAM,ANTXR2,CA12,CD44,CDH1,CDKN1A,EGR3,F2R,FMN1,FOXC1,FREM2,HK1,IGFBP5,JAG1,KITLG,MAGI3,MAL,MMP14,MMP2,NRP1,PITX2,RARA,RET,SEMA3B,TGFA,THBS1,TIMP1 | 1504 (17) |
| C-21 | NA | chemical drug | NA | 1.26e+00 | NA | 0.0e+00 | ACTA2,CASP3,Ccl2,CX3CR1,MLKL,NCF1,SPP1,TGFB1,TIMP1 | 1169 (16) |
| nickel chloride | NA | chemical toxicant | NA | 1.26e+00 | NA | 0.0e+00 | CRYAB,DDIT4,EGLN1,GAPDH,GCLC,GLRX,Gstt3,HIF1A,KDM3A,Ldha/RGD1562690,MAFF,NFAT5,NFE2L2,PGK1,PIK3C2G,PLK3,PTGS2,SLC2A1,USF2 | 879 (13) |
| ciprofibrate | NA | chemical drug | NA | 1.26e+00 | NA | 1.0e-02 | ACADL,ADAMTS1,ANXA2,CCND2,CD36,CEACAM1,CHKA,CRP,CSTB,CXCL12,CYP27A1,CYP7B1,DIO1,DPP4,HPD,HSD17B4,ICAM1,IGF1,LOC259246 (includes others),LPL,NFKBIA,PDK4,PHLDA1,PPARG,QPCT,RGN,SELENBP1,SLC16A1,SLC37A4,SLC4A4,SLCO2A1,SLCO2B1,TAGLN2,TNFRSF10A,TRPV2,VEGFD | NA |
| 3-hydroxybutyric acid | NA | chemical - endogenous mammalian | NA | 1.25e+00 | NA | 1.0e-02 | FOXO1,HOPX,KLF5,MAG,NLRP3,SLC18A2,TLR4 | NA |
| VASP | 1.90e-01 | other | NA | 1.25e+00 | NA | 2.0e-02 | ARG1,CCND1,HIF1A,ITGA4,SELP,STAT1 | NA |
| MM-589 | NA | chemical reagent | NA | 1.25e+00 | NA | 0.0e+00 | ACTA1,ACTN2,CCDC80,CGNL1,COBL,COL16A1,COL1A1,COL3A1,COL5A2,CRYAB,ELN,FBLN1,FHOD3,HOPX,IGFBP5,LOXL2,MMP2,MYH6,MYH7,MYL1,PDGFRA,PGAM2,PLOD2,RND1,SORT1,TNFRSF11B,TNNC1,TNNT2 | NA |
| Ro31-8220 | NA | chemical drug | NA | 1.24e+00 | NA | 0.0e+00 | BCL2L1,CDKN1A,CLDN1,COL1A1,DUSP1,EGR1,FN1,HIF1A,ICAM1,ITGA5,MMP2,Mt1,PLD1,PRKCQ,PTGS2,SERPINE1,ST6GAL1,TWIST1,VCAM1 | 1225 (16) |
| branched chain amino acids | NA | chemical drug | NA | 1.24e+00 | NA | 1.0e-02 | ACTA2,CASP3,CD83,COL3A1,HIF1A,PPM1K,TEK,TGFB1,TIMP1 | NA |
| zinc protoporphyrin IX | NA | chemical - endogenous mammalian | NA | 1.24e+00 | NA | 1.0e-02 | CCND1,CDKN1A,GCLC,HGF,IGF1,MET,PTGS2 | 1533 (22) |
| mir-101 | NA | microRNA | NA | 1.24e+00 | NA | 1.0e-02 | COL1A1,COL3A1,DUSP1,EZH2,FZD6,PRKDC,PTGS2,RUNX1,STMN1 | 626 (7) |
| 1-chloro-2-(2,2,2-trichloro-1-(4-chlorophenyl)ethyl)benzene | NA | chemical toxicant | NA | 1.23e+00 | NA | 1.0e-02 | AHR,ARNT2,CDKN1A,CYP7B1,GADD45A,GADD45B | NA |
| Vhl | NA | complex | NA | 1.23e+00 | bias | 3.0e-02 | BIRC3,CCND1,INHBB,TGFB1 | NA |
| parthenolide | NA | chemical drug | NA | 1.22e+00 | NA | 3.0e-02 | ADAMTS5,ANKRD1,AXIN2,BCL2L1,CASP1,Ccl2,CERS4,LEF1,MITF,NFE2L2,NKD1,PDK4,PTGS2,VCAM1 | NA |
| tempol | NA | chemical drug | NA | 1.22e+00 | NA | 0.0e+00 | BCL2L1,BMP4,CYBA,F3,GCH1,ICAM1,NCF1,NOS1,NOX1,PTGS2,RRAD,SERPINE1,SGK1,SPP1,TGFB1,VCAM1 | 1368 (20) |
| N-[(2Z)-3-(4,5-dihydro-1,3-thiazol-2-yl)-1,3-thiazolidin-2-yl idene]-5H dibenzo[a,d][7]annulen-5-amine | NA | chemical reagent | NA | 1.22e+00 | NA | 3.0e-02 | BCAR1,CD44,CREM,CYP1B1,ECH1,ESRRG,FGF2,GAMT,HGF,IGF1,MMP2,MTHFD2,NFATC4,NR0B2,NR4A3,RERG,S100A4,SERPINE1,SPP1,TWIST1,UBC | NA |
| C9orf72 | 2.80e-01 | other | NA | 1.22e+00 | NA | 5.0e-02 | EDN1,EDNRB,GLUL,NUP210,PC,SLC1A1,SLC1A3 | NA |
| SERPINA3 | NA | other | NA | 1.21e+00 | NA | 1.0e-02 | Ccl2,COL1A1,FOXO1,ICAM1,NOX4,RIPK3,RUNX2,SREBF1,TLR4 | 1184 (23) |
| mir-148 | NA | microRNA | NA | 1.21e+00 | NA | 0.0e+00 | ABCA1,ACTA2,ALCAM,AQP4,BCL2L11,CDH1,CDH2,COL1A1,EGR1,ITGA1,MBNL1,MMP15,MMP2,PKM,ROCK1,SNAI2,SOCS1,VIM | 713 (13) |
| tamoxifen | NA | chemical drug | NA | 1.20e+00 | NA | 0.0e+00 | ACKR3,BCL2L1,BDNF,BMP4,BMP5,C3,CASP8,CAV1,CAV2,CCDC80,CCNA2,CCND1,CD36,CDH1,CDH11,CDH2,CDK2,CDK6,CDKN1A,CEBPD,CENPK,COL11A1,COL1A1,CXCL12,CXCR4,DLK1,DNAJA1,EIF4EBP1,EPHA4,EPHX1,ERBB3,ETV5,F13A1,F2R,FABP1,FADD,FADS1,FADS2,FHL2,FLOT1,FN1,G0S2,GAP43,GAPDH,GJB2,GPATCH3,HAS2,HGF,HIF1A,IDH3A,IER3,IGF1,IGFBP4,IL1RN,IRF1,IRS1,KIF11,KIF4A,LOXL2,LPCAT1,LSS,LTBP2,MAFF,MET,MKI67,MMP2,MTO1,MX1,NFATC4,NNMT,NOS1,NR0B2,NRCAM,OXTR,PFN1,PHGDH,PKM,PPARG,PPP5C,PSMB5,PTGS2,RBL1,RERG,S100A6,Scd2,SCN1B,SCTR,SELE,SEMA3B,SFTPB,SLC1A1,SLC2A1,SLC9A3,SMAD7,SNAI1,SPP1,SREBF1,Syt7,TAGLN,TGFA,TLR4,TOR3A,UGCG,USP1,UTRN,ZEB2 | 1691 (21) |
| estradiol-17beta-benzoate | NA | chemical reagent | NA | 1.20e+00 | NA | 0.0e+00 | ABCA4,ATOX1,BDNF,BGN,C1QTNF4,CCND1,CD74,CHST11,CLIC6,COL1A1,COL2A1,COL3A1,COL8A1,Cox8b,DOCK5,EFS,EZR,FMOD,GFAP,GFRA1,GLDN,GLUL,GPR88,GRAP,HBA1/HBA2,HLA-A,HLA-DQA1,HS3ST5,ISLR,JAK3,KCNJ13,LBP,LUM,MRC2,MYCN,NECTIN1,NET1,NR4A2,NR5A2,NTS,NXPH3,OXTR,Pcp4l1,PCSK1N,PIM3,PON3,RDH5,REC8,RET,RRAD,SCAND1,SDC1,SFRP5,SOSTDC1,SV2B,TACR3,TC2N,TGFB1,TIMM13,TIPARP,TNFRSF11B,TYRO3,UNC5B,UQCR11,WNT4 | 817 (12) |
| irbesartan | NA | chemical drug | NA | 1.20e+00 | NA | 0.0e+00 | ADIPOQ,CD36,CYBB,FHL1,HGF,HRAS,ICAM1,ITGB3,SERPINE1,SERPINF1,SMAD6,TGFB1,VCAM1 | 1299 (21) |
| CDKN2A | NA | transcription regulator | NA | 1.20e+00 | NA | 0.0e+00 | A2M,ACTA2,AK1,AMD1,ASNS,BARD1,BCAT1,BCAT2,BCL11A,BCL11B,BCL2L11,BTG2,BTG3,BUB1B,C3,CASP3,Ccl2,CCL24,Ccl6,Ccl7,CCNA2,CCND1,CCNI,CDC25B,CDCA4,CDCA7L,CDK2,CDKN1A,CDKN2C,CEBPD,CENPK,CITED2,CNOT6L,COL1A1,CRP,CSF1,CX3CL1,CXCL10,CXCL13,CXCL14,CXCR5,DDR1,DEK,DONSON,DUSP1,E2F2,EBF1,EEF1A1,EGR1,EGR2,EHD3,Esrra,EZH2,FAM111A,FANCA,FEN1,FGFR1,FHL2,FN1,GADD45G,GAS7,GLUL,GNA13,GNAS,GPT2,HACD3,HGF,IGFBP5,IL2RG,IL7,ITGA2,ITGB3,KAT5,KCNK1,KIT,KITLG,LEF1,MCM7,MCM8,MET,MKI67,MMP2,MRC1,MYCN,MYL2,NOX4,PBX3,PDGFC,PHGDH,PLAGL1,PLK1,PMEPA1,PTGS2,PTX3,RAB27A,RBL1,S100A6,SERPINE1,SHMT1,SKP2,SNTB2,SREBF1,TGFA,TGFBI,TLR4,TNFRSF1B,TOB2,TP63,VEGFC,VIM,ZBTB16,ZNF385A | 1432 (20) |
| evodiamine | NA | chemical - endogenous non-mammalian | NA | 1.20e+00 | NA | 1.0e-02 | BCL2A1,BCL2L1,BIRC3,CASP3,CCND1,EIF2AK3,ICAM1,PTGS2,SELE | 954 (14) |
| BAG6 | 4.70e-01 | enzyme | NA | 1.20e+00 | NA | 3.0e-02 | CDKN1A,COL1A1,SERPINE1,SESN1 | NA |
| IRF4 | -1.68e+00 | transcription regulator | NA | 1.19e+00 | NA | 0.0e+00 | ALPK2,ARG1,B2M,BCL6,BIRC3,Ccl2,CD28,CDC14A,CDK2,CDK6,CIITA,CTSS,CX3CR1,CXCL10,CXCR4,DOCK8,ELL2,ENTPD1,ERBB3,EZR,FOXP3,IKZF2,IL15RA,IL17A,IL17RA,IL1R1,IL1RN,IL2RA,IL33,INPP4B,INPP5D,IRF1,IRF2BP2,IRF4,IRF5,ISG15,ITGAL,LEF1,LYST,PPIB,PRDM1,PRKCQ,PTP4A2,RAB7A,RHOA,RPL6,RUNX2,SLC2A1,SPP1,STAT1,TMSB10/TMSB4X,TNFRSF8,ZBTB20,ZFP36L1 | 1125 (14) |
| Cathepsin | NA | group | NA | 1.19e+00 | NA | 0.0e+00 | ACTA2,CCND1,CCND2,MKI67 | 1288 (13) |
| DLGAP1 | -2.40e-01 | other | NA | 1.19e+00 | NA | 0.0e+00 | CDH1,CDH2,MMP2,VIM | NA |
| FGF1 | -1.07e+00 | growth factor | NA | 1.19e+00 | NA | 0.0e+00 | ACTA1,ADGRE1,AHR,ANGPT2,AXIN2,Ccl2,CCND1,CDH1,CDH11,CDKN1A,DLL1,DUSP6,EDN1,EGR1,FGFR1,FHOD3,FRMD3,FZD1,FZD2,GADD45G,GCLC,HAS2,ICAM1,IKZF2,IRS1,LRRC17,MKI67,NFE2L2,NR4A2,PMEPA1,PTGS2,PXYLP1,RFLNB,SELE,SNAI2,SPP1,Tcf7,TGFB1,THBS1,VCAM1,VEGFC | 1317 (15) |
| IL27RA | -8.40e-01 | transmembrane receptor | NA | 1.19e+00 | NA | 4.0e-02 | BCL6,Ccl2,CCR5,CD44,CD86,CXCL10,CXCL13,IL17A,IL2RA,PRDM1,SOCS3,STAT1 | NA |
| EZH2 | -1.39e+00 | transcription regulator | NA | 1.19e+00 | NA | 0.0e+00 | ACKR3,ADAM10,ADRB2,ARHGDIB,ATF3,AXIN2,BCL11A,BCL11B,BCL2L1,BCL2L11,BIRC3,BMP1,BMP4,C15orf48,C3,CACNA1E,CACNG4,Ccl2,CCND1,CCND2,CCNE2,CCR5,CDH1,CDH2,CDK6,CDKN1A,CLEC3B,CNR1,COL1A1,COL5A1,CSF1,CSF3R,CTNNAL1,CX3CL1,CXCL10,CXCR4,CYB5R2,CYP1B1,DAAM1,DAB2IP,DENND2A,DMP1,DUSP5,EGR1,EPC1,EZH2,EZR,FANCB,FBLN1,FBN1,FGFR1,FHOD3,FKBP5,FOXO3,FOXP3,FRZB,FUCA1,FZD1,GATA4,GPR68,HGF,HOXB5,HOXD10,ICAM1,IGF1,IL10RA,IL17A,IL18R1,IL7,IRAK3,ITGA1,JAM2,KCNA1,KCNK1,KIT,KITLG,KLF4,LAMC2,LBX1,MAL2,MAT2A,MCM8,MMP2,MPZL2,MYOD1,NCOA7,NFKBIA,NKD1,NKD2,NOTCH2,NOX4,OXTR,PARP9,PAX3,PDGFB,PDGFC,PDGFRA,PER1,PITX2,PLA2G4A,PPARG,PPP2R2B,PRDM1,PROM1,PTGES,PTGS2,PTN,RAP1GAP,RASSF5,RASSF9,RNASEH1,RNF5,RUNX1,RUNX2,S100A4,SCAMP2,SFRP2,SFRP4,SFRP5,SLC1A3,SNAI1,SOCS1,SOCS3,SOX10,SPARC,STT3A,TBX3,TGFA,TGFB1,TGFBI,TMPRSS2,TWIST1,VEGFC,WNT10B,ZBTB16 | 1618 (27) |
| SLC2A3 | -2.70e-01 | transporter | NA | 1.19e+00 | bias | 0.0e+00 | ALDOA,G6PD,GAPDH,GPI,H6PD,LDHB,PFKFB3,PHGDH,PKM | NA |
| N-[amino(dimethylamino)methylidene]-4-[(3aS,9bR)-8-ethoxy-7-methoxy-1,3,3a,9b-tetrahydrofuro[3,4-c]isoquinolin-5-yl]benzamide | NA | chemical reagent | NA | 1.19e+00 | bias | 1.0e-02 | ACTA2,COL1A1,FN1,SERPINE1 | NA |
| miR-3648 (miRNAs w/seed GCCGCGG) | NA | mature microRNA | NA | 1.19e+00 | bias | 0.0e+00 | ADCK5,ASB13,B3GALT6,CCND1,CD44,CLIP2,DMTN,FAM131C,FBRSL1,HIF1A,HOXC5,JUND,KIF21B,KLHL25,LZTS2,MAP1LC3B,MLXIP,MYO18A,NCOR2,NRARP,OTUD1,PELI2,PER3,PRX,PTPN6,RTN4R,TLE2,ZBED3,ZNF219,ZSWIM8 | NA |
| CTDSP1 | -4.00e-02 | phosphatase | NA | 1.18e+00 | NA | 5.0e-02 | CDH1,RHOA,TWIST1,VIM | NA |
| HBP1 | 2.50e-01 | transcription regulator | NA | 1.18e+00 | NA | 0.0e+00 | CCL24,CCND1,CDKN1A,EZH2,IL7,MYCN,MYOD1,MYOG,PDK4,PKM,PTGS2 | 1489 (23) |
| nifedipine | NA | chemical drug | NA | 1.18e+00 | NA | 0.0e+00 | ABCA1,ABCC3,ABCC8,ADIPOQ,ATP2B3,ATP2B4,BDNF,Ccl2,EDN1,FAM3B,FN1,IGFBP5,IRS1,KCNJ11,MYH7,MYOG,NOS1,NR4A1,NTRK2,PTGS2,SGK1,STAR,TYMS,VCAM1 | 1216 (18) |
| plicamycin | NA | chemical drug | NA | 1.17e+00 | NA | 0.0e+00 | ABCA1,AHR,AVPI1,AXL,CA9,CDKN1A,COL1A1,CX3CL1,CYBRD1,DNM1,F3,FOXO3,FYN,GJB2,GLTP,GPD1,HDAC4,HIF1A,IER5,IGFBP4,KDR,MET,MYH14,NAPA,NFE2L2,OLFM1,PLXDC1,PRDM1,PRKCD,PRKDC,PROM1,SEMA7A,SERPINE1,SOCS3,STARD10,TESC,TIMP1,UBC,VWF,WNT9A,XYLT1 | 1579 (22) |
| TRIM31 | NA | enzyme | NA | 1.17e+00 | NA | 1.0e-02 | ACADL,CD36,CDKN1A,FABP1,PDK4,PPARG,SLC27A1 | NA |
| miR-140-5p (and other miRNAs w/seed AGUGGUU) | NA | mature microRNA | NA | 1.17e+00 | bias | 0.0e+00 | ADAMTS5,CXCL12,EGR2,HDAC4,IGFBP5 | NA |
| RLN2 | NA | other | NA | 1.17e+00 | NA | 0.0e+00 | ACTA2,CASP1,CD36,EDNRB,MMP2,NLRP3,NOS1,PYCARD,TGFB1,TIMP1,TLR4 | 721 (12) |
| zoledronic acid | NA | chemical drug | NA | 1.17e+00 | NA | 0.0e+00 | ACP5,BCL2L1,CDH1,CTSK,CXCR4,FZD5,IL2RA,IRAK3,LPAR1,MMP2,NCAM1,NOX4,PPARG,PTGS2,RUNX2,SOCS1,SPARC,TLR4,TNFRSF11B,WNT5A | 1478 (18) |
| cyclopentenone | NA | chemical reagent | NA | 1.17e+00 | NA | 5.0e-02 | CCND1,HSPA1A/HSPA1B,ICAM1,PTGS2 | NA |
| MST1 | 4.00e-01 | growth factor | NA | 1.16e+00 | NA | 1.0e-02 | BCL2L1,CCND1,FOXP3,GPC3,IL1RN,IRF8,MSR1,NR0B2,PTGS2,SPP1 | 1499 (22) |
| carbon monoxide | NA | chemical - endogenous mammalian | NA | 1.16e+00 | NA | 0.0e+00 | ADORA2A,BDNF,CASP3,CAV1,CDKN1A,CXCL12,EGR1,F3,FADD,FN1,HGF,HIF1A,ICAM1,IRF8,MAPK14,NCF1,NCF2,PRDX1,PTGS2,SELP,SERPINE1,TGFB1,TLR4 | 1158 (16) |
| pirinixic acid | NA | chemical toxicant | NA | 1.16e+00 | NA | 0.0e+00 | ABCA1,ABCC3,ACADL,ACADS,ACOT8,ACSL1,ACSL5,ADH1C,ALDH9A1,ANXA2,ASNS,BMP15,BPGM,C3,Ccl2,CCNA2,CCND1,CD200,CD36,CDH2,CDK2,CDKN1A,CEACAM1,CFH,CFI,COL1A1,CRP,CXCL12,CYP27A1,CYP7B1,DAD1,DPP4,DYNLL1,ECH1,ELOVL1,ELOVL5,ENTPD1,F3,FABP1,FADS1,FADS2,FBP2,FBXO32,FCER1G,FEN1,FOXC2,G0S2,G6PD,GADD45A,GADD45B,GAPDH,GBE1,GLUL,GNB4,GPAM,GPD1,GPD2,GRHPR,HGF,HIF1A,HLA-DQA1,HMGN1,Hmgn2 (includes others),HSD17B4,HSP90AA1,HSPE1,ID2,IFITM3,IL1RN,IRF8,KDR,KLF10,Ldha/RGD1562690,LDHB,LOC259246 (includes others),LPL,MET,MGST2,NFKBIA,NRG4,PCSK5,PDK4,PGM1,PHLDA1,PIK3R3,PLA2G2A,PLIN4,PLTP,POPDC3,PPARG,PPIC,PSMA4,PSMB1,PSMB5,PSMC1,PTAFR,PTGS2,PTPRC,PTPRF,RXRA,RXRG,SERPINE1,SLC27A1,SREBF1,TBCA,TRIM63,TSKU,UBQLN2,UCP3,VCAM1,VEGFD,WEE1,YWHAQ | 1148 (16) |
| mir-192 | NA | microRNA | NA | 1.15e+00 | NA | 0.0e+00 | ACTA2,ALCAM,CDKN1A,CTNNBIP1,FN1,MSN,NOD2,TYMS,ZEB2 | 1173 (10) |
| MAP2K5 | 3.10e-01 | kinase | NA | 1.15e+00 | NA | 1.0e-02 | AACS,ACTA1,BCAR1,CCND1,CREM,DHCR7,KLF5,LSS,MSMO1,MVD,MVK,NR4A1,NR4A3,PTGS2,SREBF1,THBS1 | 1070 (25) |
| LMO2 | -1.34e+00 | transcription regulator | NA | 1.15e+00 | NA | 0.0e+00 | ACVR1B,ADAMTS9,AHR,ANXA1,APOBEC1,AXIN2,BCL11A,BCL9,BTK,C8orf44-SGK3/SGK3,CASP1,CASP3,CCND2,CD34,CD53,CD93,CDKN1A,CDKN2C,CERS4,COL18A1,CPA3,CPEB1,CSF2RA,CSTB,DAB2IP,DACT3,DHX58,DLK1,DPP4,DUSP15,ENG,ENO2,EPB42,EPHB4,F2R,FBLN1,FZD5,FZD6,GBP5,GDF11,GOLM1,GPR183,GPR34,HHEX,HIVEP3,HLX,HOXA5,IFIH1,IL2RA,IL34,IRS2,ITGAE,ITGB7,ITM2C,KIT,LEF1,LGALS1,LHFPL2,LMCD1,LYN,MDK,MGST2,MITF,MYH10,NDN,NOD2,NOVA1,NSG2,Oasl2,OXCT1,PKD2,PLA2G4A,PLCG2,PSTPIP1,PTPN3,PTPRJ,RAB32,RASGRP1,RIPK2,RNPEP,RRAD,RXRA,SAMSN1,SERPINF1,SLC16A1,SLC7A8,SMOX,SNTB2,SOBP,SPRED1,TAL1,Tcf7,TES,TGFB1,THEMIS2,THY1,TLR2,TNFRSF10A,TNFRSF1B,TNFRSF8,TOR3A,UNC93B1,WNK2,ZNF518B | 984 (13) |
| geldanamycin | NA | chemical drug | NA | 1.15e+00 | NA | 0.0e+00 | AARSD1,ACTA2,ANXA1,ANXA2,ARF1,ARRDC5,BCL11B,BCL2L1,BGN,BIN1,BRI3,CASP8,CCND1,CDKN2C,CEBPD,CELF2,CIITA,CNP,DBNDD2,DNAJB1,DNAJC1,EEF1A1,EGR3,FADD,FAU,FGFR1,FKBP5,FYN,HACD3,HAP1,HIF1A,HLA-DQA1,HLA-DRA,HLTF,HRAS,HSP90AA1,HSPA1A/HSPA1B,IFI16,IKBKB,IL1RL1,IRF1,IRF5,IRS1,IRS2,KCNA5,KNL1,LBH,MAP2K2,MAP2K4,MAP4K1,MET,NLRP3,NTN1,NUDC,OPTC,PARK7,PFN1,PLK1,PPM1A,PRIMA1,PTGS2,RAB11B,RAB2A,RAB2B,RAB7A,RHOA,RIPK3,SAFB,SAFB2,SCN2B,SNX33,SPN,STAT1,THBD,TPPP,TYMS,UHRF1,WEE1,YWHAQ,ZC3H12D,ZNF532 | 1410 (20) |
| andrographolide | NA | chemical drug | NA | 1.15e+00 | NA | 1.0e-02 | BCL2L1,CASP3,CDH1,CNR1,FN1,ICAM1,OXTR,PTGS2,RGN,SELE,TIMP1,VCAM1 | NA |
| Gm12602 | NA | other | NA | 1.14e+00 | bias | 0.0e+00 | ANPEP,BRSK1,BTG2,CGREF1,CRYAB,DHRS9,DUSP5,Tpm1 | NA |
| Collagen type IV | NA | complex | NA | 1.13e+00 | NA | 0.0e+00 | ACTA2,DPYD,GFAP,ITGB3,MMP14,MMP2,PTGS2,SERPINE1,TAGLN,THBS1 | 1483 (20) |
| BRAP | 1.01e+00 | enzyme | NA | 1.13e+00 | NA | 1.0e-02 | COL4A6,COL6A3,JAG1,MOB1A,NOTCH2,OBSCN,STK3 | NA |
| 2-arachidonoylglycerol | NA | chemical - endogenous mammalian | NA | 1.13e+00 | NA | 1.0e-02 | CNR1,F3,FGF2,LPIN1,PPARD,PPARG,PTGS2 | NA |
| DUSP5 | 1.13e+00 | phosphatase | NA | 1.13e+00 | NA | 4.0e-02 | ALDH1A3,EGR1,EGR3,HIVEP3,ID2,PRDM1,ZFP36 | NA |
| HSD17B4 | -8.10e-01 | enzyme | NA | 1.13e+00 | NA | 4.0e-02 | ACSL1,ALOX5,CD36,GLI1,GLI2,PDK4,PTCH1,PTGS2 | NA |
| mir-506 | NA | microRNA | NA | 1.13e+00 | bias | 2.0e-02 | GFRA1,SNAI2,SPDEF,TLR4,VIM | NA |
| glycerol | NA | chemical - endogenous mammalian | NA | 1.13e+00 | NA | 4.0e-02 | ABCA1,ADIPOQ,GLI1,PPARG,PTCH1,TLR4 | NA |
| VHL | -2.60e-01 | transcription regulator | NA | 1.13e+00 | NA | 0.0e+00 | AIF1,ALDH1A1,BCL2L1,BCL2L11,BHLHE40,CA12,CA9,CAV1,CCND1,CDH1,CDH2,CDKN1A,CFL1,CNN1,CXCL12,CXCR4,CYBRD1,DAB2,DUOX2,ENO2,F3,FN1,FTL,GBE1,GLO1,HIF1A,HYAL1,IER3,IFITM3,ITGA5,LOX,LOXL2,MAF,MAVS,MMP14,MYL12B,NEDD9,NEK8,NOSIP,NOX4,PDGFB,PFKFB3,PREB,QPRT,RHOF,RUNX1,SIGLEC8,SKP2,SLC16A3,SLC1A3,SLC2A1,SPARC,TAGLN,TGFA,TMED3,TYMS,VCAM1,VEGFC,VIM,ZFP36L1 | 1426 (22) |
| miR-27a-3p (and other miRNAs w/seed UCACAGU) | NA | mature microRNA | NA | 1.12e+00 | bias | 0.0e+00 | CTNNBIP1,CYP1B1,EPHB4,FADD,FOXO1,GCA,IFI16,IGF1,MYH7,OCLN,Pmaip1,PNPLA2,PNPLA3,PPARG,RUNX1,RXRA,SREBF1,ST14,VAV3,WEE1 | NA |
| PP1 | NA | chemical drug | NA | 1.12e+00 | NA | 0.0e+00 | ANGPT2,BCL2L1,BCL2L11,CCND2,CDH1,CDK2,CXCL16,CXCR4,IL1RN,MMP2,PTGS2,SERPINE1,SIRPA,TAGLN,VCAM1 | 1411 (16) |
| cilostazol | NA | chemical drug | NA | 1.12e+00 | NA | 0.0e+00 | ABCA1,ABCG1,BDNF,EIF2AK3,GCH1,GFAP,ICAM1,KDR,MITF,NR4A2,OCLN,PDGFC,SELE,SELP,SERPINE1,TLR4,VCAM1 | 965 (17) |
| NRAS | 9.00e-02 | enzyme | NA | 1.12e+00 | NA | 0.0e+00 | AK1,AKAP12,ANKRD1,ANXA8/ANXA8L1,Arxes1/Arxes2,B2M,BCL2L1,CALCRL,CCND1,CD34,CD48,CD86,CDKN1A,CEACAM1,CFH,CKM,CLEC11A,Crip2,CTSE,CX3CL1,CX3CR1,CXXC5,CYBB,DUSP6,EGR1,EIF2AK3,ENPEP,EPHX1,ETS1,ETV1,ETV5,EXOC4,FHL1,FN1,GBP2,GLI1,HIF1A,HLA-A,HOMER3,IFI16,IFIH1,IFIT1,IL1RN,ISG15,ITGA2,KDR,LBP,LGALS1,LY86,MITF,MKI67,MSR1,NCAM1,NCF2,NFE2L2,NPR3,P3H4,PENK,PLEKHO1,PLTP,PON3,PTGS2,PTP4A3,PTPRC,PTX3,Rap2a,SBNO2,SCX,SDC1,SESN1,SKP2,SLC2A1,SPC25,SPRED2,SPRY4,STAT1,SV2B,TMEM43,TULP4,USP18,WEE1,XPNPEP2 | 1284 (17) |
| ZBED6 | NA | transcription regulator | NA | 1.11e+00 | NA | 2.0e-02 | BOP1,COL13A1,DDIT4,KCTD1,KITLG,MAFA,MAP3K14,MB21D2,MYBL1,PMEPA1,SGK1 | NA |
| mir-154 | -3.00e-01 | microRNA | NA | 1.11e+00 | NA | 5.0e-02 | ACTA2,ADAMTS1,ATF3,BCL2L11,CCND1,CDH1,FZD4,KIT,KLF10,PMP22 | NA |
| AZ505 | NA | chemical reagent | NA | 1.11e+00 | NA | 0.0e+00 | ACTA2,FN1,SMAD7,SNAI1,TWIST1 | 1296 (16) |
| 19,20-epoxydocosapentaenoic acid | NA | chemical - endogenous mammalian | NA | 1.11e+00 | NA | 0.0e+00 | ACTA2,CDH1,S100A4,SNAI1,ZEB2 | 411 (6) |
| RB1CC1 | -1.00e-02 | other | NA | 1.11e+00 | NA | 1.0e-02 | ALDH1A3,CCND1,CDKN1A,CXCL10,SERPINE1,SMAD7 | 1518 (25) |
| PDLIM2 | 0.00e+00 | other | NA | 1.11e+00 | NA | 0.0e+00 | CCND1,CDH1,CHPF,CITED2,F2RL1,FOXRED2,FSTL1,FXYD6,GHDC,GNG2,HLA-DOB,IFI44,IL7,KIT,MME,MPZL2,NAV1,NPR3,NR2F1,NUDT11,OAS3,PCSK1N,PHLDA1,PRR16,PRUNE2,RNF128,SCARA3,SERF1A/SERF1B,SLC22A3,SMOC1,STAT1,TAGLN | 1438 (20) |
| SFLLRN (PAR1-activator) | NA | chemical reagent | NA | 1.10e+00 | NA | 1.0e-02 | DOK2,F13A1,GAPDH,PDLIM1,PEBP1,PLEK,RGS10,RGS18,SELP,SNCA,TAGLN2 | NA |
| imatinib | NA | chemical drug | NA | 1.10e+00 | NA | 0.0e+00 | ARL6IP1,ATP1B1,ATP1B2,ATP6V0B,ATP6V1A,ATP6V1F,BCAT1,BCL2L1,BCL2L11,BCR,CACNA1B,CASP3,CASP8,CCNA2,CCND1,CCND2,CDK2,CDKN1A,CDKN2C,CITED2,COL1A1,COL3A1,COX6B1,CXCL10,CXCL12,CXCR4,CYBB,DAB2,ECT2,EIF2AK3,ESPL1,ETV5,FN1,FOXO3,GADD45A,HBA1/HBA2,HRAS,HSPA2,HSPE1,Ifi47,IL7,IP6K2,IRF1,IRF4,ITGA1,KAT5,KDR,KIF11,KIT,LMAN2,LMO2,LSM10,LYN,MADD,MAP2K4,MAPK4,MCM7,MME,NDFIP2,NDUFA1,NDUFA7,NDUFC1,NDUFC2,NR2F2,OPTN,PDIA4,PLK1,PRPF4B,RAB31,RAB8A,RASA2,RPS6KB1,SKP2,SLC20A1,SLC25A6,SRSF1,STAT1,TGFB1,TMOD1,TNFRSF10A,UQCR10,UQCR11,VCP,ZDHHC17 | 1574 (22) |
| PRC2 | NA | complex | NA | 1.10e+00 | NA | 4.0e-02 | CEACAM1,GATA4,HOXB5,HOXD10,IRF4,JAM2,KDR,LRAT,MMP2,MX1,NKD1,PPP2R2B,TBX3 | NA |
| galunisertib | NA | chemical drug | NA | 1.09e+00 | NA | 0.0e+00 | CDH1,CDH2,FN1,SNAI1,VIM | 1265 (17) |
| BCL6 | 1.74e+00 | transcription regulator | NA | 1.09e+00 | NA | 0.0e+00 | A2M,ALCAM,ARG1,BCL2A1,BCL2L1,BCL3,BCL6,CASP3,Ccl2,Ccl6,Ccl7,CCND1,CCND2,CD44,CDKN1A,CIITA,CISH,COL1A1,COL2A1,CSF1,CTSK,CUX2,CWC27,CXCL10,CXCR5,DOCK10,DPYSL2,DUSP6,EGR3,ENTPD1,FCGRT,FGF2,FMOD,FOXP3,FUT7,GABARAPL1,GADD45A,GOLM1,HDAC9,HERC6,HOXD9,IL17A,IL2RA,IL2RB,IRF1,IRF4,IRF8,ITGA3,KLF6,LBH,LDHB,LITAF,LPIN1,MAF,MITF,MRC1,PDP2,PHF20,PI4K2B,PIK3CG,PLA2G2A,PLA2G4A,Pmaip1,PRDM1,PTPRO,RGS4,RHOF,SDC1,SERPINE1,SH2D4A,SH3D19,SLC39A8,SMPDL3B,SOCS3,SOX6,STAT1,STAT6,SYK,TGFB1,TIMP1,UBA7,ZC4H2 | 1191 (16) |
| LDB1 | 1.60e-01 | transcription regulator | NA | 1.09e+00 | NA | 0.0e+00 | ACVR1B,ADAMTS9,AHR,ANXA1,APOBEC1,AXIN2,BCL11A,BCL9,BTK,C8orf44-SGK3/SGK3,CASP1,CASP3,CCND2,CD34,CD53,CD93,CDKN1A,CDKN2C,CERS4,COL18A1,CPA3,CPEB1,CSF2RA,CSTB,DAB2IP,DACT3,DHX58,DLK1,DPP4,DUSP15,ENG,ENO2,EPB42,EPHB4,F2R,FBLN1,FRZB,FZD5,FZD6,GBP5,GDF11,GOLM1,GPR183,GPR34,HHEX,HIVEP3,HLX,HOXA5,IFIH1,IL2RA,IL34,IRS2,ITGAE,ITGB7,ITM2C,KIT,LEF1,LGALS1,LHFPL2,LMCD1,LYN,MAFA,MDK,MGST2,MITF,MYH10,NKX6-1,NOD2,NOVA1,NSG2,Oasl2,OXCT1,PKD2,PLA2G4A,PLCG2,PSTPIP1,PTPN3,PTPRJ,RAB32,RASGRP1,RIPK2,RNPEP,RRAD,RXRA,SAMSN1,SERPINF1,SFRP1,SFRP2,SLC16A1,SLC7A8,SMOX,SNTB2,SOBP,SPRED1,TAL1,Tcf7,TES,TGFB1,THEMIS2,THY1,TLR2,TNFRSF10A,TNFRSF1B,TNFRSF8,TOR3A,UNC93B1,WNK2,ZNF518B | NA |
| LEPR | -2.02e+00 | transmembrane receptor | NA | 1.09e+00 | NA | 0.0e+00 | ABCG1,ACTA2,ADAM17,ADGRE1,ADIPOQ,ALCAM,ALDH1A1,ALOX15,ANXA5,ATF3,ATP2A2,BCL2L1,BTG1,CASP8,Ccl2,CDK2,CNR1,COL1A1,EDN1,EIF4EBP1,EXOC4,FN1,GADD45B,GADD45G,GAP43,GATA4,GFAP,GPAM,HIF1A,HSPA1A/HSPA1B,ID2,IGF1,IL17A,IL18BP,IL1RN,IRS2,LEPR,LPL,MC4R,MMP14,MMP19,MMP2,NFATC3,PC,PLP1,PPARD,PPARG,PROM1,RETN,RPL7L1,SELE,SERPINE1,SMARCD3,SOCS3,SREBF1,TGFB1,TIMP1,TNFRSF4,TRPV1 | 1197 (18) |
| hymecromone | NA | chemical drug | NA | 1.09e+00 | NA | 0.0e+00 | ACKR3,ACTA2,BCL2L1,CASP3,CASP8,CAV1,CD44,CXCR4,FADD,FOXP3,HAS3,MMP2,TNFAIP6,TNFRSF10A | 1213 (17) |
| RHO | 5.00e-02 | G-protein coupled receptor | NA | 1.09e+00 | NA | 0.0e+00 | B2M,CACNB2,CASP3,CD44,CD74,CEBPD,CSF1R,CTSS,DPYSL3,FBLN1,GNAT1,HCLS1,KCNA1,Mt1,NCAM1,NID1,PCOLCE,PLA2G7,S100A6,SELENOP,SERPING1,SGK1 | 1007 (9) |
| PSEN1 | 2.60e-01 | peptidase | NA | 1.09e+00 | NA | 0.0e+00 | ABCG1,ACO2,ACSL1,ACTA1,ACTG1,ALDOA,ATOX1,ATP1B1,ATP2A2,ATP6V1A,ATP6V1E1,AXL,BDNF,C1R,C3,C3AR1,CAMK2D,Casp12,CASP3,CCND1,CCR5,CCS,CD74,CD9,CDH2,CDK5R1,CFL1,CFL2,CKMT1A/CKMT1B,CLTB,CRYM,CTSC,CTSS,CYTIP,DBP,DLL1,DNAJC5,DPY19L3,DPYSL2,DUSP1,EGR1,EIF5A2,ELOVL4,EMP1,ENO2,ERMP1,F2R,FOXO3,FZD4,GADD45B,GAPDH,GDF11,GFAP,GNG2,HBA1/HBA2,HINT1,HK1,Hnrnpa3,HOMER1,HSP90AA1,HSPE1,IGF1,IRF3,IRF4,IRF5,L1CAM,LHX8,MAP2,MAP2K2,MME,MSR1,NCAM1,NOS1,OCEL1,Pcp4l1,PDGFRA,PEA15,PEBP1,PER3,PGK1,PIK3R1,PKM,PKP3,PLVAP,PPARG,PPIA,PRC1,PRDX5,PSENEN,PSTPIP1,PTGS2,PTPRF,PVALB,RELN,S100B,SLC38A2,SNCA,SOCS1,Sp100,STMN1,SYP,TGFB1,TIPARP,Tpm1,TPPP,TUBA1A,TUBA8,TUBB,TUBB6,UBC,UEVLD,VSNL1,Zfp101 | 1362 (17) |
| MEN1 | -5.00e-02 | transcription regulator | NA | 1.09e+00 | NA | 0.0e+00 | ACTA2,CASP8,CCND1,CDH1,CDKN1A,CDKN2C,EZH2,FKBP5,FN1,FOXC1,FOXC2,GLI1,HIF1A,INHBB,IRS2,MAFA,NKX6-1,PTN,PTPRZ1,RUNX2,SNAI1,TWIST1,VIM | 1550 (22) |
| JARID2 | 3.30e-01 | transcription regulator | NA | 1.09e+00 | NA | 1.0e-02 | CCND1,CCND2,CDH1,CDKN1A,MYL1,MYOG,PPARG,SREBF1,TGFB1,ZEB2 | 1394 (21) |
| asoprisnil | NA | chemical drug | NA | 1.09e+00 | NA | 1.0e-02 | APOD,CASP3,DPP4,EGF,G0S2,GZMB,IGF1,IL2RB,RARRES1,SGK1,SLC3A1,WNT4 | NA |
| POLDIP2 | NA | other | NA | 1.08e+00 | NA | 1.0e-02 | ARG1,GFPT2,KLF4,MYOCD,OGT,SREBF1,TAGLN | NA |
| LILRB1 | NA | transmembrane receptor | NA | 1.08e+00 | bias | 1.0e-02 | CAV1,DEPTOR,FOXO3,MAF,MMP2,PRDM1,RECK,SDC1,ST3GAL6 | NA |
| NDRG1 | 3.20e-01 | kinase | NA | 1.08e+00 | NA | 0.0e+00 | ATF3,BCL2L11,CASP3,CAV1,CCND1,CDH1,CDH2,EGR2,EIF2AK3,ERBB3,ERRFI1,GLI1,ITGB4,MAP1LC3B,MAPK3,MET,SNAI1,SNAI2,SOX10,TNC,TP63,VIM | 1455 (19) |
| FHIT | NA | enzyme | NA | 1.08e+00 | NA | 2.0e-02 | CDKN1A,MMP14,MMP2,RAB2A,RAB31,RAB7A,RABAC1,RABIF,RANBP1,SNAI2,VIM | NA |
| DANCR | NA | other | NA | 1.07e+00 | NA | 0.0e+00 | CDH1,CDH2,LIPG,RUNX2,SNAI1,SNAI2,VIM | 832 (12) |
| MYO1B | -3.10e-01 | other | NA | 1.07e+00 | bias | 0.0e+00 | ALDOA,GAPDH,GPI,HIF1A,PGK1,PKM,SLC2A1 | 1006 (7) |
| HTATIP2 | 2.60e-01 | transcription regulator | NA | 1.07e+00 | bias | 1.0e-02 | ANGPT2,CCND1,CDH1,CDH2,MMP2,PKM,SNAI1,SPARC,SPP1 | 1374 (19) |
| RGS19 | -3.00e-02 | enzyme | NA | 1.07e+00 | NA | 3.0e-02 | AXIN2,BMP4,GATA4,MYH7 | NA |
| CCX771 | NA | chemical reagent | NA | 1.07e+00 | NA | 3.0e-02 | CD44,CXCL12,CXCR4,OCLN | NA |
| tosyllysine chloromethyl ketone | NA | chemical - protease inhibitor | NA | 1.07e+00 | NA | 3.0e-02 | IRF1,NFKBIA,PTGS2,SPN | NA |
| 2,5-bis(5-hydroxymethyl-2-thienyl)furan | NA | chemical reagent | NA | 1.07e+00 | NA | 4.0e-02 | CDKN1A,GADD45A,HIF1A,RNF8,WNT4 | NA |
| AKAP12 | -1.13e+00 | transporter | NA | 1.07e+00 | NA | 5.0e-02 | CCND1,CDH1,HIF1A,MMP2 | NA |
| setanaxib | NA | chemical drug | NA | 1.07e+00 | bias | 5.0e-02 | ACTA1,ACTA2,CD44,SLC2A1 | NA |
| miR-18a-5p (and other miRNAs w/seed AAGGUGC) | NA | mature microRNA | NA | 1.06e+00 | bias | 0.0e+00 | AXIN2,BCL2L11,BTG3,CCND1,CDKN1A,E2F2,HIF1A,HSF2,SOX6,THBS1,TP63,WNK2 | 706 (7) |
| RBM5 | 1.00e-01 | other | NA | 1.05e+00 | NA | 1.0e-02 | ANXA1,BIRC3,BMP5,BTG2,CDK2,GBE1,HSP90AA1,ICAM1,IFITM3,ISG15,NDUFV2,PLK4,SERPINH1,STAT5B | NA |
| sildenafil | NA | chemical drug | NA | 1.05e+00 | NA | 0.0e+00 | AIF1,BCL2L1,BDNF,CASP3,COL1A1,CREM,CXCL13,CYBB,FGF1,FN1,GFAP,HSPE1,PDE5A,PTGS2,RHOA,SLC9A1,SYP,TRPC6,VEGFC | 1612 (22) |
| MACROH2A1 | NA | other | NA | 1.05e+00 | NA | 0.0e+00 | ABCA1,ACADL,ALDH1A3,ANXA2,BRCA2,CCND2,CD36,CDK5R1,CDKN1A,CDKN2C,CITED2,CTHRC1,EDN1,EGR1,ETS1,FGD3,FGF1,FN1,GADD45A,HIF3A,HUS1,IL16,IRS1,LPL,NOTCH4,PPARG,PTPRO,SERPINE1,SLC2A1,SNAI1,SPARC,TBX3,TWIST1 | 1250 (23) |
| ACE2 | 1.10e-01 | peptidase | NA | 1.05e+00 | NA | 0.0e+00 | ACTA2,CASP3,CASP8,Ccl2,Ccl7,CXCL10,CYBB,FN1,GAD1,MMP2,NOS1,NOX4,PTGS2,SERPINE1,SMAD7 | 1193 (14) |
| obeticholic acid | NA | chemical drug | NA | 1.05e+00 | NA | 1.0e-02 | ACTA2,ADIPOQ,Akr1b7,Ccl2,CDH1,COL1A1,DDAH1,FN1,ICAM1,NR0B2,PPARG,PTGS2,SMAD6,SREBF1,TGFB1,TIMP1 | 1213 (18) |
| JAK inhibitor I | NA | chemical drug | NA | 1.04e+00 | NA | 1.0e-02 | BCL2L1,C3,CCND2,CXCL10,IL17A,PTGS2,SGK1,SOCS1,SOCS3,TIMP1 | NA |
| Firre | NA | other | NA | 1.04e+00 | NA | 1.0e-02 | ACADS,ADCK5,ARHGAP45,COTL1,CROCC,CSK,DHX38,EDF1,EEF1D,HIRIP3,LZTS2,MAGEE1,MAP2K2,MBD3,PALM,PEX6,PRR5,RPS15,TAGLN2,TKT,TRABD,TSC22D4,VCAM1 | NA |
| SP2509 | NA | chemical reagent | NA | 1.04e+00 | NA | 0.0e+00 | ABCC4,ADAMTS1,ANKRD1,B3GNT2,BAIAP2,BCAT1,BCL11A,BDNF,BMP5,BUB1B,CCNA2,CCND1,CCND2,CDH1,CDH2,CDK5R1,CDK6,CENPF,CREB1,CUX1,CXCL10,DDR2,DDX6,DEK,E2F5,E2F8,ELF4,EPHA3,EZR,FEZ1,FGF2,FGFR1,FLRT3,FN1,FOXC1,FUBP1,GAP43,GLI2,INPP5F,KIF5C,KLF4,L1CAM,LEF1,LGALS1,LOX,LTBP1,MAP1S,MAP2,MET,MICALL2,MKI67,MOB2,MSI1,MSN,NCAM1,NEFL,NEK6,NR4A2,OGT,OLFM1,OSTN,PLCB1,PLK2,PON2,PREX1,RET,SDC2,SEMA3C,SGK1,SIAH2,SLC38A1,SLC7A1,SMO,SMYD2,SPP1,SRSF1,STAG1,STAT5B,STAT6,STEAP2,TNC,TWIST2,TYRO3,UBXN1,UNC13A,USF2,VCAN,WDR77,XPO1,ZFP64,ZFYVE27,ZSWIM6 | NA |
| EHD2 | -8.00e-02 | other | NA | 1.03e+00 | NA | 0.0e+00 | ADIPOQ,CAV1,CAV2,PNPLA2,PPARG,SREBF1 | NA |
| linolenic acid | NA | chemical - endogenous mammalian | NA | 1.03e+00 | NA | 1.0e-02 | ACSL1,CD36,EDN1,FABP1,ICAM1,LEPR,NFKBIA,SELP,SERPINE1,SNCA | 1419 (21) |
| ATP-gamma-S | NA | chemical reagent | NA | 1.03e+00 | NA | 0.0e+00 | ASAH2,BTG1,C3,CASP1,CCL24,CCR1,CCR5,CD109,CD83,CD86,CREM,CSF1,CSF1R,CST7,CXCR4,ENTPD1,FOXO3,GAP43,IL15RA,IL16,IL1R1,IL1RN,IL2RA,IRF4,MMP19,NCF2,NLRP3,NRP1,PYCARD,SOCS3,TGFA,THBS1,TLR5,TLR7,TLR8 | 1304 (15) |
| STO-609 | NA | chemical - kinase inhibitor | NA | 1.03e+00 | bias | 0.0e+00 | Ccl7,F3,MAF,SELE,SELP,STAR,VCAM1 | 964 (11) |
| RPSA | 3.90e-01 | translation regulator | NA | 1.02e+00 | NA | 0.0e+00 | Ccl7,DUSP1,GBP4,Ifi47,IL1R1,ISG15,ITGA6,MMP2,PTGS2,REL,STAT1,TLR4 | 1471 (17) |
| KLF2 | -5.80e-01 | transcription regulator | NA | 1.02e+00 | NA | 0.0e+00 | ACKR3,ANGPT2,APLN,APLNR,BCL3,BMP4,CAV1,Ccl2,Ccl7,CCR3,CCR5,CD36,CD44,CD86,CD93,CDH2,CDKN1A,CNP,CRP,CX3CR1,CXCR4,CXCR5,CYP1B1,DLL1,DOCK2,ECM1,EDN1,ELN,F2RL1,F3,FBLN1,FGR,FOXP3,GADD45A,GATA4,HIF1A,HPSE,IL17A,IL1RL1,IL2RG,ITGA4,ITGB2,ITGB3,ITGB4,ITGB7,KDR,KITLG,LBP,LEPR,MMP14,MYH10,NFKBIA,NOTCH2,PDPN,PLOD2,PLPP3,PPARG,PRDM1,PROS1,PTGIS,PTGS2,PTPRJ,RUNX2,SEMA3F,SERPINB9,SERPINE1,SLC2A1,SLCO2A1,SREBF1,STAT1,TBX5,TFPI2,TGFB1,THBD,THBS1,TIMP1,TNFRSF4,TNFRSF8,UGDH,VCAM1,VWF,WEE1 | 1255 (18) |
| ADIPOQ | -9.40e-01 | other | NA | 1.02e+00 | NA | 0.0e+00 | ACSL1,ACSL5,ACTA1,ACTA2,ADIPOQ,ARG1,BCL3,Ccl2,CCND1,CD36,CDKN1A,CMKLR1,COL3A1,CXCL10,CYBA,CYBB,CYP1B1,DLK1,DUSP1,EGR1,F3,FABP1,FADS2,FGFR1,FN1,FOXP3,FZD1,FZD2,FZD4,FZD6,GPD1,HPD,ICAM1,IGFBP4,IL17A,IRS1,LEPR,LPL,MMP2,MSR1,NCF1,NCF2,NCF4,NFKBIA,NOX4,PFKFB1,PPARD,PPARG,PRDX5,PRKAA2,PTGS2,ROCK1,RUNX2,SIGLEC10,SLC27A1,SOAT1,SOCS3,SREBF1,SYP,TGFB1,TIMP1,UCP3,VCAM1,VEGFC,WNT10B,WNT11,WNT2,WNT4,WNT5A,WNT6,WNT9A | 1448 (20) |
| Laminin (complex) | NA | complex | NA | 1.02e+00 | NA | 0.0e+00 | ACTA2,BIRC3,CCND1,CDH11,CDK5R1,COL1A1,ETV5,FN1,ID2,ITGA6,PTGS2,PTPRF,RUNX2,SDC4,SERPINE1,SKP2,SNAI2,VIM,WNT5A | 1482 (20) |
| caffeic acid | NA | chemical drug | NA | 1.02e+00 | NA | 1.0e-02 | AHR,HGF,NFE2L2,PTGS2,SNAI1,SREBF1,TLR4 | 1327 (20) |
| CYB5R4 | -1.70e-01 | enzyme | NA | 1.01e+00 | NA | 4.0e-02 | ACSL3,ATF3,CD36,GCLC,LPL,Mt1,Scd2 | NA |
| salinosporamide A | NA | chemical drug | NA | 1.01e+00 | NA | 1.0e-02 | BCL2L1,BIRC3,CCND1,CDH1,HIF1A,ICAM1,PEBP1,PTGS2,SNAI1 | 1118 (11) |
| MTOR | 9.00e-02 | kinase | NA | 1.00e+00 | NA | 0.0e+00 | ACADL,ALDH1A3,ATP2A2,BCL2A1,BCL2L1,BCL2L11,CASP1,CASP3,CASP8,CCND1,CD86,CDH1,CDKN1A,CEBPD,CHKA,CITED2,CKMT1A/CKMT1B,CNP,COX4I1,CSF1R,CXCR4,DDAH2,DDIT4,DUSP1,ERCC1,FADD,FBXO32,FN1,FOXP3,GAP43,GZMB,HBA1/HBA2,HIF1A,HK1,IFI16,IGF1,IL17A,IL1R1,IL2RB,INHA,IP6K2,IRF1,IRF8,IRS1,IRS2,LDHB,MADD,MAF,MAG,MAP1LC3B,MAP2,MB,MDH1,MIA,MICAL1,MOG,MYH8,MYOG,NAB2,NCAM1,NFKBIL1,NOX4,PDE4A,PDK2,PDK4,PFN1,PGP,PGRMC1,PKM,PLD2,PLP1,PPARD,PPARG,PPARGC1B,PPIB,PRDX5,PRKAR2B,PRKCZ,PRX,PSMB5,PTPN6,RAB11B,RHOA,RPL23,RPS11,RPS18,RUNX2,SGCA,SKP2,SLC16A3,SLC26A3,SLC2A1,SNAI2,SOAT1,SOCS3,SREBF1,ST6GAL1,STAT1,TBRG1,TLR4,TLR5,TMCC1,TMPRSS2,TNFRSF10A,TNFRSF11B,TNFRSF25,TPPP,TRADD,TRIM63,TXNL1,UTRN,VCAM1 | 1513 (19) |
| OVOL2 | -1.42e+00 | transcription regulator | NA | 1.00e+00 | bias | 0.0e+00 | ALDOA,ARHGEF2,BTRC,CDKN1A,CDKN2C,EFNA5,EPHA4,GPI,MMP2,NR2F1,PGK1,PKM,SKP2,SLC2A1,STARD8,TUBB4A,VIM,WIPF1 | NA |
| PDLIM1 | -1.28e+00 | transcription regulator | NA | 1.00e+00 | NA | 0.0e+00 | CDH1,PDLIM1,SNAI1,VIM | 1230 (12) |
| HCAR2 | -1.27e+00 | G-protein coupled receptor | NA | 1.00e+00 | NA | 0.0e+00 | AVEN,CCNE2,IQGAP3,NMI,PLK1,PLK4,PTGS2,SLC37A2,WEE1 | NA |
| NT5E | 2.00e-01 | phosphatase | NA | 1.00e+00 | NA | 0.0e+00 | Ccl2,COL1A1,COL3A1,IGF1,KDR,MKI67,SERPINE1,SPP1,TGFB1,TIMP1 | 1360 (17) |
| ATPase | NA | group | NA | 1.00e+00 | NA | 0.0e+00 | CTSK,ICAM1,MMP14,VCAM1 | NA |
| CDHR1 | -2.40e-01 | other | NA | 1.00e+00 | bias | 1.0e-02 | CEBPD,GFAP,OSMR,SOCS3 | NA |
| carboxymethylflavin | NA | chemical - endogenous mammalian | NA | 1.00e+00 | NA | 1.0e-02 | GLI1,MMP2,PTCH1,TIMP1 | 640 (7) |
| formylmethylflavin | NA | chemical - endogenous non-mammalian | NA | 1.00e+00 | NA | 1.0e-02 | GLI1,MMP2,PTCH1,TIMP1 | 640 (7) |
| GABA receptor | NA | complex | NA | 1.00e+00 | NA | 1.0e-02 | BDNF,NR4A1,NR4A2,NR4A3 | 417 (7) |
| lumichrome | NA | chemical - endogenous non-mammalian | NA | 1.00e+00 | NA | 1.0e-02 | GLI1,MMP2,PTCH1,TIMP1 | 640 (7) |
| RBP1 | -8.60e-01 | transporter | NA | 1.00e+00 | NA | 1.0e-02 | ALDH1A1,PPARG,RARA,RBP7,RXRA,STRA6 | NA |
| MYPN | 5.40e-01 | other | NA | 1.00e+00 | NA | 2.0e-02 | ANKRD1,CASQ2,MYH6,SORBS2 | NA |
| momelotinib | NA | chemical drug | NA | 1.00e+00 | NA | 2.0e-02 | CDH1,CDH2,SNAI2,VIM | NA |
| sesamin | NA | chemical - endogenous non-mammalian | NA | 1.00e+00 | NA | 2.0e-02 | ABCC3,CASP3,NCF1,PTGS2,TNFRSF11B | NA |
| MAZ | 5.70e-01 | transcription regulator | NA | 1.00e+00 | NA | 3.0e-02 | ATF3,CAV1,CCL24,CDKN1A,CX3CL1,FKBP11,IL1RN,MAFA,NKX6-1,PDIA4,PNMT,PPARG,TNFSF8 | NA |
| garcinia yunnanensis extract YTE-17 | NA | chemical reagent | NA | 1.00e+00 | NA | 3.0e-02 | ADGRE1,ARG1,CSF1,MRC1 | NA |
| evofosfamide | NA | chemical drug | NA | 1.00e+00 | bias | 3.0e-02 | CCND1,CCND2,CDK6,CDKN1A | NA |
| HINT1 | 6.70e-01 | enzyme | NA | 1.00e+00 | NA | 3.0e-02 | ELOVL5,FADS1,FADS2,USF2 | NA |
| HEYL | -3.40e-01 | transcription regulator | NA | 1.00e+00 | NA | 3.0e-02 | GATA4,MMP2,MYH6,TMPRSS2 | NA |
| CNOT6 | -7.80e-01 | enzyme | NA | 1.00e+00 | bias | 5.0e-02 | CDKN1A,CLEC3A,IGFBP5,SEMA3E | NA |
| miR-423-5p (and other miRNAs w/seed GAGGGGC) | NA | mature microRNA | NA | 1.00e+00 | bias | 5.0e-02 | ACTA1,CDH1,CDH2,VIM | NA |
| baricitinib | NA | chemical drug | NA | 1.00e+00 | bias | 5.0e-02 | CXCL10,DNASE1L3,IL17A,STAT1 | NA |
| BIN1 | 9.20e-01 | other | NA | 1.00e+00 | NA | 5.0e-02 | CDH1,CDH2,MMP2,SNAI1 | NA |
| VIP | 5.60e-01 | other | NA | 1.00e+00 | NA | 2.0e-02 | CASP8,Ccl2,CCND1,CD86,CEBPD,CREB1,CXCL10,EGF,EGR2,EGR3,FOXP3,IGF1,IL17A,IL1RL1,IL2RA,IRAK2,IRF1,LGALS1,NFKBIA,PTGS2,SIGIRR,SLC1A3,SORT1,STAR,TLR4,TLR8,VIM | NA |
| candesartan | NA | chemical drug | NA | 9.90e-01 | NA | 0.0e+00 | ACTA1,Ccl2,COL3A1,CREB1,ENG,FN1,ICAM1,MMP14,MMP2,MYH7,NCF1,NPR3,OLR1,RHOA,SERPINE1,SLC9A3,SPP1,TGFB1,TRPC3 | 1456 (22) |
| DUSP1 | -1.15e+00 | phosphatase | NA | 9.90e-01 | NA | 0.0e+00 | AACS,ACVR1C,ATP2A1,CALCR,Ccl2,CD86,CFB,COL3A1,CTSK,CXCL10,CYBB,DUSP1,DUSP6,GJB2,ICAM1,IER3,IFI16,IFI44,IFIH1,IFIT1,IFITM3,IL1RN,IRAK3,IRF1,IRF4,IRF8,ISG15,LUM,MRC1,MX1,MYH2,MYH7,MYOG,NRP1,OASL,OLR1,PDGFB,PIK3R1,PLAT,PRDM1,PTGS2,RSAD2,RTP4,SELE,SERPINE1,SLC15A3,SOCS1,SOCS3,THBD,TLR2,USP18,VCAM1,VEGFC,ZFP36 | 1292 (15) |
| PP2/AG1879 tyrosine kinase inhibitor | NA | chemical drug | NA | 9.90e-01 | NA | 0.0e+00 | BCL2L11,BIRC3,CDH1,CDH2,CDKN1A,CXCL16,DUSP1,EDN1,EPHA3,FGF2,FGR,FN1,GRIA2,HIF1A,HOXD10,ICAM1,IL2RA,LYN,MYOG,NCF1,PER1,PTGS2,PTPRJ,RHOA,SERPINE1,SPP1,VIM | 1288 (16) |
| NPC1 | 2.20e-01 | transporter | NA | 9.80e-01 | NA | 0.0e+00 | ABCA1,ABCG1,ACKR4,ATP6V1A,ATP6V1E1,ATP6V1F,B2M,BIN1,CAV1,CAV2,CCND1,CCR1,CCR3,CCR5,CD22,CD276,CD74,CHKA,CSF1R,CTSH,CTSK,CX3CR1,CYP27A1,EGR1,GPR34,HDAC7,HLA-A,KLF4,LAMP2,LAMTOR2,LAMTOR5,LIPG,LPL,LSS,MMP14,MMP15,MRC1,MVD,MVK,MYLIP,OSBPL3,P2RY12,PLIN4,PLP1,PNPLA3,PRDX1,PTGS2,RAB7A,SNCA,SREBF1,STAT1,SYP,TGFB1,TLR4,TMEM119,VTI1B | 1141 (19) |
| (+)-MK-801 | NA | chemical drug | NA | 9.80e-01 | NA | 0.0e+00 | ALDOA,ATP1B2,BDNF,CACNB3,CCND1,CDKN1A,CNTN2,CREM,EGR1,FGF2,GJA5,GJC1,HSPA1A/HSPA1B,ICAM1,INPP4B,ITGA2B,ITGB3,JUND,NFKBIA,NPTXR,NTRK2,NTS,PTGS2,PTPRF,RHOA,Rnase2 (includes others),RUNX2,SYT3,TIMP1 | 1314 (18) |
| benzyl isothiocyanate | NA | chemical - endogenous non-mammalian | NA | 9.70e-01 | NA | 2.0e-02 | BCL2L1,BCL2L11,CCND1,CDH1,HIF1A,ICAM1,MET,MMP2,PTGS2,ROS1,SELE,SERPINE1,VCAM1,ZBTB34 | NA |
| hydroxypropyl-beta-cyclodextrin | NA | chemical drug | NA | 9.70e-01 | NA | 0.0e+00 | ABCA1,ABCG1,APLN,APOD,C2,CALB1,CD1D,CD44,CLIP2,CSF1,CX3CR1,CXCL13,CXCL14,CXCR5,ELOVL1,ENG,GFAP,GLTP,LAMTOR2,LPIN1,LSM4,MYLIP,NCEH1,NFATC4,NLGN3,PLTP,QRICH1,RXRA,SCAMP5,SDC1,TLR4,TLR8,UBA3,VCAM1 | 1094 (15) |
| entinostat | NA | chemical drug | NA | 9.70e-01 | NA | 0.0e+00 | ADAMTS5,BCL2L1,BCL2L11,CCND1,CD44,CD83,CDH1,CDKN1A,CSF2RA,CXCL10,DUSP1,ERBB3,FOXP3,HDAC7,HIF1A,LGR5,MICB,MMP2,NFE2L2,RUNX2,SERPINE1,SNAI2,THBS2,TNFRSF10A,TNFRSF19 | 1306 (18) |
| NEDD4 | NA | enzyme | NA | 9.70e-01 | NA | 3.0e-02 | ABCG1,CDKN1A,DUSP6,ERBB3,ERRFI1,FN1,SNCA | NA |
| NTF3 | 4.20e-01 | growth factor | NA | 9.60e-01 | NA | 1.0e-02 | ACTA1,ATP2A1,CCND2,CDH1,CKM,ETV1,Naip1 (includes others),PENK,PVALB,TNNC2,TNNI2,TRPV1 | 1209 (22) |
| ADORA2A | 6.20e-01 | G-protein coupled receptor | NA | 9.60e-01 | NA | 1.0e-02 | ABCA1,ATP2A2,ATP2B3,BDNF,Ccl2,CD28,COL3A1,CSF1R,CXCL10,DAPK3,DUSP1,EGR2,GAPDH,GLI1,GPI,HBA1/HBA2,HIF1A,IFITM3,KIF5A,KLC1,NAPA,NFKBIA,NR4A1,NR4A2,NR4A3,NTRK2,OCLN,PEA15,PENK,PTGS2,ROCK1,SELE,SPARC,TGFB1,TUBB4A | 1293 (16) |
| rosiglitazone | NA | chemical drug | NA | 9.60e-01 | NA | 0.0e+00 | ABCA1,ABCG1,ACADL,ACADS,ACO2,ACSL1,ACSL5,ACTA1,ADAM17,ADAMTS1,ADGRE1,ADIPOQ,ALOX5,AQP7,ARG1,ATP1A1,BDNF,C3,CASP3,CAV1,CAV2,Ccl2,Ccl7,CCND1,CCNE2,CCRL2,CD1D,CD36,CD86,CDH1,CDKN1A,CIITA,CKM,COL1A1,COL3A1,COX4I1,Cox8b,CREB1,CRP,CSF1,CTSS,CXCL10,DDHD1,ECH1,EDN1,EGLN1,EGLN2,ERP44,ETS1,F3,FABP1,FGF1,FN1,GAPDH,GBP2,GPAM,GPAT3,GPD1,GPR65,GRIA2,H6PD,HAS2,HCAR1,HCAR2,HGF,HLA-DRA,HTR2B,ICAM1,IDH1,IDH3A,IGF1,IGFBP5,IGFBP6,IL17A,IL1RN,INHBA,IRF1,IRS1,IRS2,ITGA1,ITGA3,ITGAD,ITGAL,ITGB3,KLF4,Ldha/RGD1562690,LOX,LPIN1,LPL,LRG1,LTB4R,MAN1C1,MAT2A,MCM7,MET,MR1,MRC1,MSR1,MYOG,NCK2,NDUFV1,NOX1,NOX4,NPR3,OAS3,OLR1,PC,PDGFRA,PDK4,PEA15,PECR,PENK,PIK3R1,PLCL1,PLIN1,PLPP3,PLTP,PNPLA2,PPARG,PPARGC1B,PRDM16,PTGES,PTGS2,PTPRO,RETN,RGS2,RUNX2,SEMA3C,SERPINE1,SERPINF1,SGK1,SKP2,SLC27A1,SLC27A3,SLC27A6,SLC2A1,SLC9A1,SLC9A3,SNAI1,SOAT1,SOCS1,SOCS3,SPN,SREBF1,STAT1,THBS1,THBS2,TIMP1,TLR4,TNC,TRIM63,TSHR,UCP3 | 1525 (21) |
| ACTC1 | 1.25e+00 | enzyme | NA | 9.60e-01 | bias | 0.0e+00 | ACTA1,ACTA2,CYBB,NOX4 | NA |
| NSRP1 | 2.80e-01 | other | NA | 9.50e-01 | NA | 0.0e+00 | CDH1,CDH2,FN1,VIM | 779 (11) |
| fluticasone propionate | NA | chemical drug | NA | 9.40e-01 | NA | 0.0e+00 | ABCG1,ALOX5,BGN,C3,C8orf44-SGK3/SGK3,CD36,CD74,CD83,CD86,CFB,CHI3L1,CLEC12A,CLEC4A,CRP,CSF2RA,CXCL10,DCN,DDIT4,EMP1,FBLN5,FKBP5,FSCN1,GADD45B,GBP5,GJB2,GLDN,HLA-DQA1,HLA-DRA,IFIT1,IL18BP,IL1RN,IRF8,IRS2,ITGB7,KLF9,LPL,MDFIC,METTL7A,MMP19,MX1,OLFML2B,OLFML3,OLR1,PCOLCE2,PDK4,PHLDA1,RARRES1,SDC4,SELENOP,SERPINE1,SERPINF1,SESN1,SIGLEC10,SLA,SLAMF1,SLC1A3,SLC2A5,SPP1,ST6GAL1,STAT1,TBC1D16,TGFB1,THBS1,TIMP1,TPST1,VWF | 1403 (15) |
| GRN | -5.10e-01 | growth factor | NA | 9.40e-01 | NA | 0.0e+00 | ABCA7,ADAMTS5,AIF1,AXL,B2M,BIN1,C3,CASP3,Ccl2,CCND1,CD300LF,CD74,CD9,COL2A1,CSF1,CST7,CTSS,CX3CR1,CYBA,FZD2,GPNMB,GPR34,HIF1A,HLA-DRA,ICAM1,IGF1,INPP5D,IRF8,ITGB2,LPL,MS4A6A,NCEH1,NINJ2,OLFML3,OLR1,P2RY12,PLCG2,PROS1,SIRPA,SLCO2B1,SOAT1,SPP1,SYP,TGFB1,UGT8 | 1206 (15) |
| dimethyl fumarate | NA | chemical drug | NA | 9.40e-01 | NA | 0.0e+00 | ACTA2,BDNF,CD86,F3,FN1,KDR,MRC1,NFE2L2,PTGS2,SELE,SERPINE1,SNAI1,VIM | 1000 (13) |
| beta-elemene | NA | chemical - endogenous non-mammalian | NA | 9.40e-01 | bias | 0.0e+00 | BCL2L1,SNAI1,SNAI2,TWIST1,ZEB2 | NA |
| APOA1 | 2.40e-01 | transporter | NA | 9.40e-01 | NA | 0.0e+00 | ABCA1,ATF3,CAV1,Ccl2,CHKA,CYBB,GFAP,ICAM1,LCAT,MYH6,MYH7,MYL2,PTGIS,PTGS2,SLC2A1,SREBF1,TGFB1,TLR2,TLR4,VCAM1 | 907 (20) |
| linsitinib | NA | chemical drug | NA | 9.30e-01 | NA | 0.0e+00 | ACTA2,CD44,COL1A1,COL7A1,FN1,SERPINE1 | 1340 (15) |
| N-cor | NA | group | NA | 9.30e-01 | NA | 0.0e+00 | ABCA1,ACSL1,ADIPOQ,ALDOA,AXIN2,BIN1,CCND1,CCR1,CD36,CDK6,CDKN1A,CRP,CTSS,CXCL10,CXCL14,ELOVL5,FADS2,FAM20C,FZD1,G6PD,HEBP1,IDH1,IGF1,INPP4B,Kctd12b,MBNL1,MCTP1,MMP2,OLR1,PDGFB,PGK1,PKM,PLIN1,PTGS2,RGL1,Scd2,SGK1,SLC2A1,SLC44A1,SNAI2,SOCS1,SREBF1,TBCC,TBX5,TRERF1,USP18,WIPF1,XYLT1 | 1152 (22) |
| ZNF503 | -1.98e+00 | other | NA | 9.20e-01 | NA | 3.0e-02 | ADORA2A,CDH1,EBF1,FOXO1,GFAP,LRAT,PENK,PLXND1,RASGRP2 | NA |
| PRKCI | -7.70e-01 | kinase | NA | 9.20e-01 | NA | 3.0e-02 | ABCC8,CCND1,CXCL10,ECT2,EZR,HK1,IRF1,KCNJ11,PRKCI,SLC2A1,SREBF1,STAT1 | NA |
| miR-133a-3p (and other miRNAs w/seed UUGGUCC) | NA | mature microRNA | NA | 9.20e-01 | bias | 2.0e-02 | CPNE3,FSCN1,KCNH2,KLF15,NFATC4,PITX3,PKM,RHOA,RUNX2,STK3 | NA |
| lisinopril | NA | biologic drug | NA | 9.10e-01 | NA | 0.0e+00 | ACTA1,Actn3,ARHGDIB,Ccl2,CYBB,GBP2,Ifi47,ITGB2,KDR,MMP2,PYGM,S100A6,TGFB1,TNNC2,TNNI2 | 568 (7) |
| oleanolic acid | NA | chemical - endogenous non-mammalian | NA | 9.00e-01 | NA | 0.0e+00 | AHR,BDNF,CCND1,CD44,CDK6,CDKN1A,GCLC,GLO1,IL17A,ITGA6,MMP2,NFE2L2,RETN,SOCS3 | 1369 (19) |
| NSC23766 | NA | chemical reagent | NA | 9.00e-01 | bias | 1.0e-02 | BCL2L1,FN1,FOXO1,MAFA,NCF1,NCF2,NOX4,PTGS2,SELP | 1268 (18) |
| miR-205-5p (and other miRNAs w/seed CCUUCAU) | NA | mature microRNA | NA | 9.00e-01 | bias | 0.0e+00 | ATP1A1,AXIN2,CDH1,CDH2,ERBB3,GGCT,HNRNPU,HRAS,MMP2,NCOR2,PARK7,PRKCE,SALL4,ZEB2 | 1377 (22) |
| bosutinib | NA | chemical drug | NA | 9.00e-01 | NA | 4.0e-02 | CCND1,CDK6,CYP1B1,EZH2,MAPK14,PLCG2 | NA |
| leuprolide | NA | biologic drug | NA | 8.80e-01 | NA | 1.0e-02 | EGR1,MMP14,MMP2,NR4A1,NR4A3,PEA15,TGFB1,TIMP1 | 1538 (24) |
| LIPE | 1.70e-01 | enzyme | NA | 8.80e-01 | NA | 0.0e+00 | ABCA1,ACADL,ACSL1,Actn3,ADGRE1,ADH1C,ADH7,ADIPOQ,ALDH1A1,ANKRD1,ANKRD2,AQP4,ATF3,BCL6,CASP8,Ccl2,CD36,CD74,CDO1,CIB2,CITED2,CLK1,COL1A1,CP,CSRP3,DMPK,EDN1,EGR1,FBP2,FKBP5,FMOD,G0S2,GAPDH,HLA-DQA1,HSPA1A/HSPA1B,ID2,IL1RL1,ITGA6,KITLG,MEOX2,MRC1,MSR1,MYH3,NET1,NFKBIB,NR4A1,PAM,PC,PDE8A,PDK4,PER1,PFKFB1,PHKG1,PLIN3,POLR2K,PPARG,PTGS2,PVALB,RARA,RRAD,RUNX2,RXRA,RXRG,SART1,Scd2,SDC4,SMAD7,SOX18,SREBF1,ST8SIA4,STAR,TGFB1,TKT,TWF2,UCP3 | 1434 (23) |
| thapsigargin | NA | chemical toxicant | NA | 8.80e-01 | NA | 0.0e+00 | ACADL,ADIPOQ,ASNS,ATF3,ATP2A2,BCL2L1,BCL6,BDNF,BIRC3,C5AR1,CA9,CAPN5,Casp12,CAV1,Ccl2,CCND1,CD83,CD86,CDKN1A,CHAC1,COL18A1,COL1A1,COL2A1,CP,CREB3L1,CREM,CSK,CXCL10,DDIT4,EDEM1,EGR1,EGR2,EIF2AK3,EIF4EBP1,ERO1B,ERRFI1,ETS1,EVI2A,FN1,GADD45A,GADD45B,HDC,HERPUD1,HIF1A,HPSE,HSPA1A/HSPA1B,ICAM1,IGF1,IL1R1,ITGA4,ITGB2,KLF4,LBH,LGR5,LMAN2,LPIN1,MET,NEDD4L,NFE2L2,NFIL3,NFKBIA,NR0B2,NR4A1,NR4A3,OLR1,PAWR,PTPN6,SDC1,SGK1,SREBF1,THBS1,TLR2,UFM1,VCAM1 | 1393 (19) |
| PHLPP1 | 5.00e-01 | enzyme | NA | 8.80e-01 | NA | 1.0e-02 | CEBPD,CSF1R,CTHRC1,FOXO1,IRS1,MAP1LC3B,PRKCB,PRKCD,PRKCE | 1245 (14) |
| 3-nitropropionic acid | NA | chemical toxicant | NA | 8.70e-01 | NA | 1.0e-02 | ATP1B1,BCL2L1,BDNF,CASP3,CNR1,COX6B1,DRAM1,ENO2,FOXO3,GAPDH,GCLC,GPI,LDHB,NOS1,PC,PENK | NA |
| INHA | 7.20e-01 | growth factor | NA | 8.70e-01 | NA | 0.0e+00 | ACTA2,ACTG2,ADAMTS1,BCAN,BOC,CCND2,CNN1,COL3A1,COL4A6,CYP1B1,CYP26B1,DHH,EMILIN2,EPHX1,ESPL1,FGFR1,GJC1,HAS2,IGFBP4,IL1R1,INHA,INHBA,INHBB,ITGA3,ITGA9,JAM2,KIF24,KIT,KITLG,KRT19,LTBP1,MATN2,MMP2,MYO18A,MYO7A,PCDH7,PIK3R1,PTGS2,PTX3,SERPINE1,SFRP4,SGK1,SMAD7,STAR | 747 (13) |
| NGEF | -1.64e+00 | other | NA | 8.70e-01 | NA | 0.0e+00 | BCL11B,CAMK1D,CCND2,CIITA,COL19A1,COL2A1,CXCR4,CYP26B1,EDIL3,ESRRG,GPNMB,HTR7,IFI44L,KIF5C,LILRA6,LIMCH1,LPAR1,METTL7A,MX1,NR0B2,NTM,OLFML2A,PFKFB1,RAPGEF4,RCAN2,RELN,RRAD,RYR1,SERPING1,SLC6A9,SMPDL3B,TAGLN,YBX2 | NA |
| NCAM1 | -1.02e+00 | other | NA | 8.60e-01 | NA | 0.0e+00 | BCL2L12,GLUL,MAP2,NCAM1,NFKBIA,NFKBIB,SYP,THBS1,THY1 | 468 (6) |
| N-acetylsphingosine | NA | chemical reagent | NA | 8.60e-01 | NA | 0.0e+00 | BCL2L1,Ccl2,CDKN1A,COL1A1,COL3A1,CRYAB,EIF2AK3,MYOD1,MYOG,PDE3B,PTGS2,RARA,RBL1,RXRA,SERPINE1,SPHK1,UGCG | 1224 (17) |
| corticosterone | NA | chemical - endogenous mammalian | NA | 8.60e-01 | NA | 0.0e+00 | ANXA1,ATP1A1,ATP1B1,BDKRB2,BDNF,CA14,CALB1,Cald1,CAV1,Ccl2,CCND1,CDKN1A,COL1A1,COL3A1,COL5A1,CYBA,DBP,DDIT4,DOCK8,DPY19L1,EDN1,EDN3,FGF2,FKBP5,GFAP,GLUL,GPAM,GZMB,HIF3A,IL2RA,IRS1,KLF9,MAPK3,NOS1,NOX4,OCLN,PDK4,PNPLA2,PPARG,PTGS2,PYGL,RELN,SFRP1,SGK1,TIMP1,TLR2,UCN,WNT10B | 1430 (19) |
| HYAL1 | -9.30e-01 | enzyme | NA | 8.50e-01 | NA | 0.0e+00 | ADAMTS5,AP1S2,ATP2B4,CASP1,CORO1C,DACH1,EPHB2,FADD,FOXO3,IGFBP4,KHDRBS1,LOX,MAP1B,PHLDB1,RUNX1T1,RUNX2,SEL1L3,SPP1,TAGLN,TBX3,TUBB,ZNF503 | 572 (7) |
| MAD2L2 | NA | enzyme | NA | 8.50e-01 | NA | 2.0e-02 | CDH1,CDH2,EGR1,SNAI2,VIM | NA |
| SFN | 5.00e-02 | other | NA | 8.50e-01 | NA | 0.0e+00 | BCL6,BTG2,CDH1,CDH2,F3,FKBP5,IL1R1,NET1,PDK4,PKP3,SGK1,SNAI2,VIM | 1848 (20) |
| PAX3-FOXO1 | NA | fusion gene/product | NA | 8.50e-01 | NA | 0.0e+00 | ABI1,ACTA1,ADRA2A,AKAP12,ANXA1,ANXA5,ARHGDIB,ATP1A1,AXL,BANF1,BTG2,BUB1,CCND1,CCND2,CD276,CDC25B,CDKN1A,CEP170B,CEP41,CHD7,CKM,CLIC1,CORO1C,CSF1,CXCR4,DAPK1,DDAH2,DUSP1,EDIL3,EMB,EPB41L3,ERBB3,ESYT1,EYA2,EYA4,FLNA,FOXO1,GAPDH,GREM1,HSP90AA1,HSPA1A/HSPA1B,IER3,IGFBP5,IRS1,ITGA5,KDR,KLF5,LIMS1,MDH1,MEOX1,MEOX2,MET,mir-133,mir-143,MORC4,MYCN,MYF5,MYF6,MYH10,MYOD1,MYOG,NAB2,NDN,NRCAM,OGN,Pmaip1,PPIC,PRC1,RPL35,RPL6,SDC1,SGO1,SKP2,SLC16A1,SOBP,SPP1,TNNT2,TOP2A,VCP,VIM,ZFP36L2 | 1384 (17) |
| 5-iodotubercidin | NA | chemical - kinase inhibitor | NA | 8.50e-01 | NA | 5.0e-02 | CASP3,CCND1,LEF1,MYCN | NA |
| AFAP1-AS1 | NA | other | NA | 8.40e-01 | NA | 3.0e-02 | AFAP1,LASP1,PFN1,RAB11B,RAC2,RHOA | NA |
| di(2-ethylhexyl) phthalate | NA | chemical toxicant | NA | 8.40e-01 | NA | 5.0e-02 | ALOX15,CCND2,CD36,CDH1,CEACAM1,DPP4,EGR1,FABP1,IRAK2,SLC27A1,SLCO2A1,SLCO2B1,SREBF1,STAR,ZFP36 | NA |
| CYP2J2 | -2.30e-01 | enzyme | NA | 8.40e-01 | NA | 1.0e-02 | ANXA1,BCL2L1,Ccl2,CD44,ICAM1,NFKBIA,PIK3CG,PPARG,SELE,VCAM1 | 1468 (24) |
| POU2F1 | 2.00e-02 | transcription regulator | NA | 8.40e-01 | NA | 0.0e+00 | A2M,ACSL1,AOX1,BCL6,CCND1,CDO1,CRP,CSF1R,CXCR5,DDIT4,ELK3,GADD45A,GBP2,GPX3,HLA-DRA,HOMER3,ICAM1,IDH1,IL17A,IRF3,JUND,LPL,NDRG4,NXN,OLR1,PDRG1,PRKAA2,PTGES,RDM1,REL,SELE,SELENOP,SERPING1,SPP1,TLR4,TMPRSS2,TNFRSF10A,TNNC1,VCAM1,VWF | 915 (8) |
| NF-Y | NA | complex | NA | 8.40e-01 | NA | 1.0e-02 | B2M,CCNA2,COL1A1,EMX2,EPHX1,GADD45A,HDAC4,HLA-DRA,LPIN1,MME,MYBL1,MYOD1,MYOG,NPR1,PENK,PKM,PROS1,SHOX2,STAR,TOP2A,TPH1,TYMS,VWF | 436 (7) |
| WP1066 | NA | chemical drug | NA | 8.30e-01 | NA | 1.0e-02 | ACTA2,CD86,CDH1,EDN1,FN1,HIF1A,MMP2,PSMB5 | 1382 (18) |
| linoleic acid | NA | chemical - endogenous mammalian | NA | 8.30e-01 | NA | 0.0e+00 | ABCA1,Ccl2,CD36,CD47,CYP4F2,DUSP1,EDN1,FABP1,ICAM1,KDR,LPL,NCF1,NEDD4L,NFKBIA,OLR1,PLIN4,PPARD,PTGS2,RXRA,SNAI2,TWIST1,TWIST2,VCAM1 | 1424 (21) |
| PLCD1 | 2.50e-01 | enzyme | NA | 8.20e-01 | NA | 0.0e+00 | CDH1,IL17A,PLCB1,SNAI1,SNAI2,TGFB1,VIM | 1231 (18) |
| ID2 | -1.08e+00 | transcription regulator | NA | 8.20e-01 | NA | 0.0e+00 | ACTA2,AXIN2,BATF,BCL2L1,BCL2L11,BCL3,BCL6,BIRC3,BTG2,CBFA2T3,CCND1,CCND2,CCNE2,CCR1,CCR5,CD44,CD83,CDC25B,CDH1,CDK20,CDKN1A,CDKN2C,CSF1,CSF2RB,CXCR4,CXCR5,DLL1,DTX1,DTX2,DUSP1,DUSP10,E2F2,EEF1D,EGR2,FCER1G,FLT3LG,FOXO1,FOXO3,Foxp1,GADD45B,GADD45G,HIF1A,HOMER2,ICAM1,IFI16,IGFBP4,IKZF2,IL10RA,IL1RL1,IL2RB,INHBB,IRF4,IRF5,IRF6,IRF8,ITGA1,ITGA3,ITGB3,KLF6,LAMA4,LEPR,LGALS1,LMO2,MAF,MAP3K14,MMP2,MPZ,NFAT5,NR4A1,NR4A3,NTRK2,PAWR,PIK3C2B,PIK3R1,PKD2,PLK1,POU2F2,PROM1,PTPN3,RAP1GAP,RAPGEF4,REL,SDC1,SEMA3F,SLAMF1,SMAD7,SOCS3,SPDEF,Tcf7,TNFRSF19,TNFRSF25,TNFRSF4,TNFSF8,TRAF5,TUBA1A,VCAM1,WNT11,WNT6,ZBTB16 | 1212 (24) |
| PRKCQ | 6.70e-01 | kinase | NA | 8.20e-01 | NA | 0.0e+00 | BCL2L1,CCND1,CD44,CDKN1A,EZR,FOXP3,IL17A,IL2RA,ITGAL,MMP2,MYOG,PRKCB,PRKCE,TNFRSF4 | 1177 (13) |
| KCNIP3 | 3.30e+00 | transcription regulator | NA | 8.20e-01 | NA | 0.0e+00 | ABR,ADRB2,BCR,CCND1,CCR5,CD28,CREM,CX3CL1,EDEM1,FCGR2B,GFAP,IL16,ITGA2,METRNL,MID1,PTGIS,SIRPA,SLC8A3,SMPDL3B,SOCS3,TNFAIP6,ZFP36 | NA |
| DACH1 | -1.15e+00 | transcription regulator | NA | 8.20e-01 | NA | 2.0e-02 | BMP4,CCNE2,CDKN1A,EGR1,FGF2,FGFR1,KLF4,PLAT,PTGS2,RELN,SERPINE1,SOCS3,TGFB1 | NA |
| SF-3-030 | NA | chemical reagent | NA | 8.20e-01 | NA | 0.0e+00 | AHR,COL1A1,COL3A1,COL5A1,MAP2K4,TNFRSF11B | 655 (7) |
| PRDX1 | -6.00e-01 | enzyme | NA | 8.20e-01 | NA | 0.0e+00 | ARG1,CD9,ECM1,EGLN1,PTGS2,REL,SELP | 1218 (17) |
| gambogic acid | NA | chemical - endogenous non-mammalian | NA | 8.20e-01 | NA | 1.0e-02 | BCL2L1,BIRC3,CCND1,EGLN1,PTGS2,TYMS | NA |
| 1’-acetoxychavicol acetate | NA | chemical reagent | NA | 8.20e-01 | bias | 3.0e-02 | BCL2A1,BCL2L1,BIRC3,CCND1,ICAM1,PTGS2 | NA |
| FAF1 | 1.70e-01 | other | NA | 8.10e-01 | NA | 2.0e-02 | AXIN2,RUNX2,SNCA,VIM | NA |
| DDIT3 | -3.10e-01 | transcription regulator | NA | 8.10e-01 | NA | 0.0e+00 | ANKRD1,ASNS,ATF3,BCL2L11,BHLHE22,CCDC80,CEBPD,DCTPP1,DDR2,DNAJA1,FAP,FN1,FOXO1,FOXP3,H6PD,HSPE1,IL17A,IRAK2,ITGA2,JAG1,LOX,MTHFD2,NFE2L2,NFIL3,NPAS2,PDPN,PER1,PLAT,PPARG,RGS4,SELE,SKP2,SNAI2,SRSF1,THBS2,TNFRSF10A,VIM | 1181 (13) |
| COL9A1 | -4.00e-02 | other | NA | 8.10e-01 | NA | 2.0e-02 | COL12A1,COL2A1,FMOD,FN1,TGFBI,THBS4 | NA |
| alpha-tocopherol succinate | NA | chemical drug | NA | 8.00e-01 | bias | 3.0e-02 | EGR1,FGF1,FGF2,VCAM1 | NA |
| HRAS | 1.46e+00 | enzyme | NA | 8.00e-01 | NA | 0.0e+00 | A2M,ACTA1,ACTG1,ADGRE5,ADRA2A,ALDH1A3,ANKRD1,ANTXR1,ANXA2,ANXA8/ANXA8L1,ARF1,ASNS,ATP2A2,B2M,B3GNT5,BCL2L1,BCL2L11,BIRC3,BMP1,BMP4,BTG2,CACNG4,CALCRL,Cald1,CALU,CAV1,CBX2,CCDC80,Ccl2,CCNA2,CCND1,CCND2,CD44,CDH1,CDH3,CDK18,CDK2,CDKN1A,CDON,CEBPD,CFB,CFH,CGREF1,CHST11,CISH,CNN1,COL18A1,COL1A1,COL2A1,COL3A1,COL5A2,Crip2,CRP,CSF1,CSRP1,CSRP2,CTSC,CTSS,CXCL10,CXCL12,CXXC5,DIXDC1,DLL1,DOK2,DPF1,DPP4,DUSP1,DUSP6,EGR1,EIF3C,EIF4EBP1,EIF5A2,ELK3,ELN,EMX2,EPHX1,ERCC1,ETS1,ETV1,ETV5,F2R,FAM167A,FGF2,FHL1,FLNA,FLRT2,FN1,FOXO1,FSTL1,FUT7,FZD1,FZD2,GADD45G,GDF10,GFER,GJB2,GLI1,GNA13,GPX3,GRWD1,HAS2,HDC,HEY2,HGF,HIF1A,HRAS,HSP90AA1,ICAM1,ID2,IGFBP4,IGFBP5,IL17RD,IL1RL1,IL7,IQGAP2,ITGA4,ITGA5,ITGA6,ITGAE,ITGB4,JAZF1,KCNC1,KHDRBS1,KLF3,KLF5,KLF6,KRT19,LASP1,LBH,LIPG,LOXL1,LRRC17,MAN1A1,MAOB,MAPK3,MET,MMP14,MMP2,MSMO1,MSRB1,MYCN,MYH10,MYL3,MYOD1,MYOG,NCOR2,NFKBIA,NID1,NRAP,NRP1,NSFL1C,OAF,OXCT1,PAWR,PDGFC,PDGFRA,PDIA5,PDLIM1,PELI2,PFN1,PLA2G4A,PLK1,PLOD2,PLS3,PLTP,PMEPA1,PPARGC1B,PPIC,PREX1,PRKCB,PRKCD,PRR5,PTGFRN,PTGS2,RAP1GAP,RASGRP1,RBBP4,RECK,RHOA,RP2,RPL23,Rpl38 (includes others),RPS10,RPS11,RPS3,S100A4,Scd2,SERP1,SERPINB9,SERPINE1,SESN1,SIRPA,SKAP2,SLIT3,SNAI1,SNAI2,SOAT1,SOCS3,SPARC,SPON1,SPP1,SPRED2,SPRY4,SREBF1,TACC3,TAGLN,TBX3,TGFB1,TGFB1I1,THBS1,TIMP1,TINAGL1,TMOD2,TMSB10/TMSB4X,TNFRSF10A,TNFRSF11B,TNFRSF1B,TOP2A,TP63,TPH1,Tpm1,TPO,TRPC3,TRPC6,TRPV1,TWIST1,TYMS,TYRO3,UBASH3B,VCAN,VIM,WLS | 1501 (23) |
| SALL4 | 8.00e-01 | transcription regulator | NA | 8.00e-01 | NA | 0.0e+00 | ADAM10,AKAP12,ANXA2,ATP1B1,BTG2,CAMK2A,CAV2,CCND1,CCND2,CD44,CD74,CDH2,CDK2,CFL2,CGN,CIITA,COL13A1,DLC1,DYNLT1,E2F2,ETS1,FGF1,FGFR1,FN1,FZD1,GJA5,GLI2,GNG2,ID2,ITGA6,KRT19,LASP1,LCP2,LEF1,LOXL2,LRRC4,MAPK3,MICB,MITF,MYH8,PCDHA4,PDGFC,PRKAR2B,PTGES,PTPRZ1,RAP1GAP,RND3,SALL4,SDC2,SEMA3C,SEMA3D,SERPINE1,SFRP1,SIRT2,SLIT3,TGFA,UTRN,VAV3,VIM,WNT5A | 1211 (13) |
| PRKG1 | NA | kinase | NA | 8.00e-01 | NA | 0.0e+00 | ACTA2,ALOX15,CCND1,CDKN1A,COL1A1,COL3A1,FN1,HINT1,IL17A,PPARG,RHOA,SERPINE1,TAGLN,TGFB1,THBS1,VCAM1 | 1293 (22) |
| THZ531 | NA | chemical drug | NA | 8.00e-01 | bias | 0.0e+00 | ABCC4,ACSL3,AHNAK2,AK4,ANKRA2,ANTXR1,ARHGEF3,ARHGEF37,CACNG4,CCM2,COLEC12,DDR2,DEPTOR,DSE,EBF2,ELL2,FKBP5,GCNT1,GFPT2,ITGA2,LETM2,MMACHC,NNMT,PAIP2B,PMEPA1,PTP4A3,RHBDF2,RILPL1,SEMA3C,SLC38A4,SORBS2,SPTLC3,SYTL2,TANGO6,TBC1D16,THBS4,TMPRSS2,TNFRSF19,TYSND1 | NA |
| glutathione | NA | chemical - endogenous mammalian | NA | 8.00e-01 | NA | 0.0e+00 | ATF3,BCL2L1,BCL2L11,CA9,Ccl2,CCND1,CDKN1A,FOXO3,GCLC,GFPT2,GPX3,HIF1A,MET,MYOD1,MYOG,PTGS2,SERPINE1,TNC,TNFRSF10A,TNFRSF8,VCAM1,ZBTB34 | 1439 (18) |
| MK2206 | NA | chemical drug | NA | 8.00e-01 | NA | 0.0e+00 | BCL2L11,CASP3,CCND1,CDH1,CDH2,EDIL3,FOXO1,HIF1A,PFKFB3,RHOA,SNAI1,SREBF1,TP63,TWIST1,VIM | 1547 (21) |
| ryanodine | NA | chemical - endogenous non-mammalian | NA | 8.00e-01 | NA | 0.0e+00 | ACTA1,BDNF,CREB1,HIF1A,PRKCZ,RHOA,STAR | 962 (19) |
| CTF1 | -4.40e-01 | cytokine | NA | 8.00e-01 | NA | 0.0e+00 | A2M,CEBPD,CRP,GATA4,IRF1,IRS1,LBP,MYH7,PNPLA2,PPARG,SOCS1,SOCS3,TAGLN,TIMP1 | 1114 (14) |
| PTCH1 | -6.50e-01 | transmembrane receptor | NA | 7.90e-01 | NA | 0.0e+00 | ACTA1,BTG2,CCND1,COL2A1,DLL1,GADD45A,GLI1,GLI2,IL33,KLF5,MTSS1,MYCN,MYOD1,PDGFRA,PTCH1,TNNI2,TNNT1 | 1122 (13) |
| SRD5A1 | -2.40e-01 | enzyme | NA | 7.90e-01 | NA | 2.0e-02 | CLDN1,CREB1,FABP1,IRS1,IRS2,Mt1,PNPLA2,PRKAA2,SREBF1 | NA |
| 4-octyl itaconate | NA | chemical reagent | NA | 7.80e-01 | NA | 2.0e-02 | GSR,HIF1A,IKBKE,ISG15,NFE2L2,PTGS2 | NA |
| OGA | NA | enzyme | NA | 7.80e-01 | NA | 0.0e+00 | ABLIM1,ACO2,ACTG1,ACTN4,ADAM19,ADAMTS5,ADGRG2,ADIPOQ,ADRM1,AHNAK2,APOBEC1,ARHGAP29,ARHGEF25,AVEN,BACH1,BCL2L1,C3AR1,CALB1,CALCRL,CAMK1D,CASP1,CASQ2,CAV1,CCBE1,Ccl2,Ccl6,CCND1,CCR1,CCR5,CD36,CD44,CD47,CD48,CD53,CD86,CD93,CDCA4,CDCA7L,CDH1,CDK2,CDK6,CDKN1A,CDKN2C,CEACAM1,CELSR1,CLDN1,CNN1,CREB5,CSF1R,CSF2RB,CX3CR1,CXCL16,DAB2,DHCR7,EGR2,ELF1,EPHA4,EPHB6,ERBB3,FBLN1,FGF9,FGFR1,FLNA,FN1,FSCN1,FZD10,FZD6,G6PD,GADD45A,GADD45G,GALNT7,GDF10,GDF11,GLUL,GPR34,GPT2,GRIN3A,HSD3B7,HSF2,IDH3A,IGF1,IGFBP4,IGFBP5,IGFBP7,IL17RD,IL1RL1,IP6K3,ITGA2,ITGB7,ITPKB,LSS,MICALL2,MMP14,MSMO1,MYO10,NDUFB9,NDUFC2,NFKBIB,NGEF,NOTCH2,OGT,PECR,PHKB,PIK3R1,PLA2G4A,PLIN3,PLPP3,PRDX4,PRKG2,PROM1,PYGL,RAB27A,S100A6,Scd2,SERPINB9,SFRP5,SIGIRR,SLAMF9,SLC27A1,SLC2A9,SOCS1,SOCS3,ST14,STAT1,TGFA,TGFB1,TGFBI,THBS1,THSD1,TIMP1,TNC,TNFRSF11B,TPD52L1,TRADD,TUBA1A,USF2,VIM,WNT11,WNT16,ZMYND10 | 1541 (20) |
| FHL2 | -1.08e+00 | transcription regulator | NA | 7.80e-01 | NA | 0.0e+00 | ACTA2,ADGRE1,ARG1,BCAR1,BCL2L11,Ccl2,CCND1,CNN1,CXCL10,CXCL12,FHL2,IL17A,INHA,MITF,MRC2,OCLN,SPP1,TAGLN,TGFB1,WNT10B,WNT5A | 1440 (18) |
| miR-139-5p (miRNAs w/seed CUACAGU) | NA | mature microRNA | NA | 7.80e-01 | bias | 5.0e-02 | FOXO1,KIT,PRC1,RUNX1 | NA |
| KEAP1 | 5.00e-01 | transcription regulator | NA | 7.80e-01 | NA | 0.0e+00 | AHR,CTSK,GBE1,GCLC,HIF1A,IL17A,MAP1LC3A,MAP1LC3B,NFE2L2,PHKA1,PPARG,PRDX1,PTCH1,SELP,TBXAS1,TOP2A,VCAM1 | 1197 (18) |
| histone deacetylase | NA | complex | NA | 7.80e-01 | NA | 1.0e-02 | CCND1,CD1D,CDH1,CSF2RA,CXCR4,HPSE,ID2,PER1,PLAT,PTGIS,SLC7A8,THBS1,TNFRSF10A | NA |
| SKIC2 | NA | enzyme | NA | 7.80e-01 | bias | 0.0e+00 | AK4,ALDOA,ASNS,BCAT1,BHLHE40,DDIT4,GAPDH,GLRX,IL33,MTHFD2,PGK1,PGM1,PLOD2,SLC1A5,SLC2A1 | NA |
| chromium | NA | chemical drug | NA | 7.80e-01 | NA | 2.0e-02 | ALG2,C1QTNF2,CAMLG,DOK5,G6PD,GCLC,Gsta4,METTL21A,NUDT16,NUMBL,PSENEN,SELENBP1,SLC1A4,TM2D2,TNFAIP2 | NA |
| NR4A3 | 1.36e+00 | ligand-dependent nuclear receptor | NA | 7.70e-01 | NA | 0.0e+00 | ACTA2,ADGRE1,BIRC3,Ccl2,CCND1,CCND2,CD300C,CDKN1A,COL16A1,COL1A1,CTHRC1,ENO3,FBP2,FOXO1,FOXP3,HIF1A,IL2RA,ITGA8,LOXL2,LPIN1,MB,MMP2,MSTN,MYH2,PPARGC1B,SERPINE1,SKP2,SLC39A8,STAR,UCP3,UHRF1 | 1445 (21) |
| HOXA5 | -6.60e-01 | transcription regulator | NA | 7.70e-01 | NA | 0.0e+00 | BIRC3,CDH1,CDH2,CDKN1A,CLDN1,COL1A1,CXCL13,EGR1,FGF10,GADD45B,IGF1,KLF10,NFKBIA,PTGS2,PTN,PTX3,RUNX2,SNAI2,TGFB1,VIM | NA |
| PPARD | 1.15e+00 | ligand-dependent nuclear receptor | NA | 7.70e-01 | NA | 0.0e+00 | ABCA1,ABCG1,ACADL,ACSL5,ACTA2,ADORA2A,ALDH9A1,AQP7,ARG1,BCL2L1,BDH1,Ccl2,CCND1,CCND2,CD36,CDK2,CYP27A1,CYP39A1,CYP7B1,DET1,DHCR7,ECH1,EGR1,FABP1,FAM131C,FCGBP,FN1,GLI1,GLI2,GPAM,GPD1,GPD2,GPR183,HSD3B7,ICAM1,IFI44L,IGFBP6,IKBKE,IL17A,LDHB,LIPG,LPL,LRAT,MAPK3,MOG,MRC1,MSR1,MYLIP,MYOM2,NR4A1,NR4A2,NR4A3,NUDT18,OAF,OCEL1,OLR1,OXCT1,Pcp4l1,PDK4,PER3,PKM,PLA2G2A,PLAT,PLP1,PNPLA2,PPARD,PPARG,PPARGC1B,PRKAG3,PTGS2,RASGRP1,RUNX2,S100A6,SLC22A3,SLC27A1,SLC2A10,SORD,SREBF1,STAT1,STBD1,TCEA3,THBS1,Tlr12,TLR5,TNFRSF11B,TRIM63,UBC,UCP3 | 1253 (19) |
| MYOG | -1.38e+00 | transcription regulator | NA | 7.70e-01 | NA | 0.0e+00 | ACTA1,CDKN1A,CHRNA1,CHRND,CKM,FBXO32,IFI16,MYF6,MYOD1,MYOG,PRIMA1,S100B,SCN4A,TRIM63 | NA |
| SCGB3A2 | NA | other | NA | 7.60e-01 | NA | 2.0e-02 | CTSS,MMP14,MMP2,SMAD7 | NA |
| ZNF382 | -4.00e-02 | transcription regulator | NA | 7.60e-01 | bias | 3.0e-02 | CDK6,IKBKE,MITF,STAT5B | NA |
| betulinic acid | NA | chemical drug | NA | 7.60e-01 | NA | 0.0e+00 | ABCA1,BCL2L1,CCND1,CXCL12,CYBA,MMP2,NOX4,PKM,PTGS2,PTPN6,SELP,SREBF1,TIMP1,TLR4 | 1350 (20) |
| hemin | NA | chemical - endogenous mammalian | NA | 7.60e-01 | NA | 3.0e-02 | ADIPOQ,BCL2L1,Ccl2,CCND1,CDKN1A,CX3CR1,CYBB,FN1,FOXP3,FTL,FXN,GFAP,HBA1/HBA2,HDAC9,HEBP1,HSF2,IGF1,IL33,MRC1,NFE2L2,NFYA,PTGS2,SPP1,TGFB1,THBD | NA |
| Hif1 | NA | complex | NA | 7.50e-01 | bias | 0.0e+00 | ALDOA,APLN,CA9,CD83,CDH1,CDKN1A,CP,CXCR4,DDIT4,EDN1,FN1,GPI,HIF3A,INHA,KCNA2,LGALS1,LOXL2,LPIN1,MET,PGK1,PKM,PPP5C,S100A4,SERPINE1,SLC16A1,SLC16A3,SLC2A1,TWIST1 | 1514 (19) |
| kukoamine A | NA | chemical - endogenous non-mammalian | NA | 7.50e-01 | NA | 0.0e+00 | ALOX5,CASP3,CDH1,CDH2,TWIST1,VIM | NA |
| HOXC8 | 7.00e-02 | transcription regulator | NA | 7.50e-01 | NA | 0.0e+00 | ADAM19,ANKRD1,Ccl2,Ccl7,CDH11,CNN1,CXCL10,ELMO1,EMB,FZD2,GREM2,KRT19,MSLN,PLAGL1,PMP22,SERPINF1,SLC16A3,SPP1,TAGLN | NA |
| TSC22D3 | NA | transcription regulator | NA | 7.50e-01 | NA | 0.0e+00 | ADIPOQ,ANXA1,BCL2L11,CASP3,CCND1,CD83,CD86,CDKN1A,COL1A1,DUSP1,EDIL3,EGR2,EGR3,ICAM1,IL2RA,PPARG,PTGS2,RUNX2,SALL4,SELE,SGK1,TLR2 | 1321 (14) |
| PD 169316 | NA | chemical drug | NA | 7.40e-01 | NA | 0.0e+00 | ABCA1,BIRC3,CCND1,CCND2,CDKN1A,FN1,PPARGC1B,PTGS2,SNAI1,VIM | 1255 (18) |
| gefitinib | NA | chemical drug | NA | 7.40e-01 | NA | 0.0e+00 | ADAMTS1,ADAMTS15,ALDH1A1,BCL2L1,BCL2L11,BDH2,BTG2,BUB1,C3,Ccl2,CCND1,CCNE2,CDH1,CDH2,CDK2,CEBPD,COL1A1,COL8A1,CTNNAL1,ECT2,EGR3,EPSTI1,ETV5,EZH2,FMO2,FSCN1,GADD45B,GLB1L,GLI1,HIF1A,HYAL1,HYAL3,ID4,IGF1,IGFBP5,IL7,ITGA2,KIF11,KIF23,KIT,KLHDC3,KRT19,LPIN1,MAFF,MCM8,MKI67,MMP15,MYCN,NOX4,NRP2,OSMR,PCDH12,PDGFRA,PPARG,PPP2R2B,PRC1,PTGER1,PTGS2,RBL1,SKP2,SLC20A1,SMC2,SMO,SPRED2,SPRY4,STAT1,TLR2,TOP2A,TSPAN8,TWIST1,VEGFD,VIM | 1485 (17) |
| MFSD2A | -1.20e-01 | transporter | NA | 7.40e-01 | NA | 2.0e-02 | DHCR7,FADS1,FADS2,IDH1,LSS,MVD,Scd2,SREBF1 | NA |
| 1,25-dihydroxyvitamin D | NA | chemical drug | NA | 7.30e-01 | NA | 0.0e+00 | BCAT1,BCKDHA,CCND1,CCND2,CDH1,CSF1,CYP27A1,EGR1,FGFR1,GLUL,IGF1,MSTN,MYF5,MYOG,PPM1K,PTPRC,SOCS1,Tlr11,Tlr12,TLR2,TLR4,TLR5,TLR7,TLR8,VIM | 1447 (23) |
| PF-573228 | NA | chemical drug | NA | 7.30e-01 | NA | 0.0e+00 | CDH1,CDH2,LOXL1,SNAI1,TP63,TWIST1 | 825 (10) |
| MIA-602 | NA | chemical reagent | NA | 7.30e-01 | NA | 2.0e-02 | CASP3,Ccl2,IGF1,IL17A,MAPK3,PTGS2 | NA |
| epothilone B | NA | chemical drug | NA | 7.30e-01 | NA | 4.0e-02 | BTG2,CDK2,CDKN1A,MKI67,THBS1,TOP2A | NA |
| AMPK | NA | complex | NA | 7.20e-01 | NA | 0.0e+00 | AACS,ACO2,ADIPOQ,BCL2L11,Ccl2,CCND2,CDH1,CDKN1A,CIITA,CLDN1,CREBZF,CXCL10,CXCL12,CYBB,CYP4F2,EGR1,Esrra,FBXO32,FOXO3,FSCN1,HIF1A,IDH3A,IL17A,IL1RN,LDHB,LITAF,LPIN1,MSTN,NCF1,NOX4,NR0B2,PAX3,PFKFB3,PLIN1,PPARG,PTGS2,RUNX2,SERPINE1,SLC2A1,SNAI1,SREBF1,STAT1,UCP3,VCAM1,VIM | 1636 (21) |
| FAS | -4.80e-01 | transmembrane receptor | NA | 7.20e-01 | NA | 0.0e+00 | ACTA2,ANXA2,ARAP2,ARFGAP1,BCL11A,BCL2A1,BCL2L1,BGN,BIRC3,BTG3,BTK,CASP3,CASP8,Ccl2,CCR1,CCRL2,CD1D,CD200,CD22,CD300C,CD44,CD48,CD83,CD86,CD93,CDK5R1,CDKN1A,CEBPD,CLTB,COL18A1,COL1A1,COL3A1,COL5A1,COL6A3,COL8A1,CREB1,CSF1,CXCL10,DUSP10,EGR1,EGR2,ERCC1,F2RL1,F3,F5,FADD,FBN1,FCGR2B,FGL2,FOXO1,FOXO3,FSCN1,GADD45G,GBP2,GPNMB,GRK5,ICAM1,IER3,IFIT1,IL10RA,IL15RA,IL16,IL17RA,IL18R1,INPP5D,IQGAP2,IRF1,JUND,LUM,LY75,MAP2K4,MET,mir-143,MME,MTMR1,MYO18A,MYO5A,NECTIN1,NFKBIA,NR4A1,NR4A2,NUAK2,OPTN,P2RY10,PDLIM7,PIK3C2B,PIK3CG,PIP4K2B,PLD1,PLD2,PRKAB1,PRKCB,PRKCI,PRKDC,PSD4,PSTPIP1,PTP4A2,PTX3,PVALB,RARA,RASGRP2,RDX,RGS14,RND1,RSAD2,RUNX2,SDC1,SELP,SERPINB9,SERPINE1,SIAH2,SIPA1,SNTB2,SPP1,STK3,SYK,TAGLN2,TGFB1,THBD,TLR2,TLR8,TNC,TNFAIP6,TNFRSF11B,TNFRSF1B,TNK2,TRIB1,TWF2,UGCG,VCAM1,WNK1,ZFP36 | 1266 (13) |
| succinic acid | NA | chemical - endogenous mammalian | NA | 7.20e-01 | NA | 0.0e+00 | ADAMTSL5,CCDC80,CD44,CFB,CLEC3B,COL1A1,Cox8b,DPP4,GAP43,HIF1A,IGFBP4,MAN1A1,SERPING1 | NA |
| M344 | NA | chemical reagent | NA | 7.20e-01 | NA | 1.0e-02 | ABCA7,ADAM10,ADAM19,APBA2,BACE2,BDNF,BIN1,GSK3A,HDAC4,PSENEN,SERPINE1,SIRT7,TGFB1 | NA |
| LYN | -1.40e+00 | kinase | NA | 7.20e-01 | NA | 0.0e+00 | ATP2A2,BCL2A1,BCL2L11,BCL3,BDNF,C5AR1,Ccl2,Ccl7,CCNA2,CD22,CD86,CDKN1A,CSF1,CXCR5,EGR1,ETS1,FCGR2B,FYN,IL17A,MITF,NFKBIA,SOCS1,SOCS3,SPHK1,STAT5B,STAT6,TRAF5 | 1164 (17) |
| WWC1 | -7.80e-01 | transcription regulator | NA | 7.10e-01 | NA | 0.0e+00 | CDH1,CDH2,FGF1,MKI67,OCLN,PDGFB,RASSF4,VIM | 590 (7) |
| Ptprd | NA | phosphatase | NA | 7.10e-01 | bias | 0.0e+00 | A2M,Ccl2,Ccl6,CDKN1A,CEBPD,CXCL14,GADD45G,IGFBP5 | 702 (7) |
| PIKFYVE | -2.00e-01 | kinase | NA | 7.10e-01 | NA | 0.0e+00 | ALDH1A1,ATF3,CD86,EIF4EBP1,FCGR1A,LY75,MAP1LC3B,SIGLEC8 | NA |
| PXDN | -7.50e-01 | enzyme | NA | 7.10e-01 | NA | 0.0e+00 | CCRL2,CDKN1A,DDIT4,DUSP1,IRS2,KLF6,LOX,NFIL3 | NA |
| NBEAL2 | 2.20e-01 | other | NA | 7.10e-01 | NA | 0.0e+00 | Ccl7,CXCL10,CXCL16,IRF8,MITF,SELP,THBS1,VWF | 1160 (17) |
| NUDT21 | 2.40e-01 | other | NA | 7.10e-01 | NA | 1.0e-02 | ARHGEF28,COL11A1,COL1A1,LAPTM4B,MTO1,PTPN12,SPARC,TEX2 | NA |
| vanillin | NA | chemical - endogenous non-mammalian | NA | 7.10e-01 | NA | 4.0e-02 | DDIT4,DUSP6,FZD2,GCLC,HSPA1A/HSPA1B,JUND,MAP2K2,TGFB1I1 | NA |
| NEDD9 | -1.07e+00 | other | NA | 7.00e-01 | NA | 0.0e+00 | ACSS3,ALOX5,AOAH,BHLHE40,CA9,CACNA1G,CD44,CDH1,DDIT4,ERRFI1,FABP1,ITGA2,KIT,MAL2,MMP14,MMP2,NAAA,PGK1,PLOD2,Podxl,PPP1R3B,SERPINE1,SLC1A1,SLC2A1,TUBA1A,VIM | 1372 (18) |
| HIC1 | -1.33e+00 | transcription regulator | NA | 7.00e-01 | NA | 0.0e+00 | ABHD3,ACKR3,ACTA2,ADRB2,AHNAK2,AMIGO2,ANO2,CA12,CCND1,CCNE2,CDKN1A,CDO1,CXCL14,CYP7B1,FADS1,FHL2,ID4,INHBA,KAZN,PLA2G4A,SPP1,TNFAIP8 | 934 (14) |
| magnesium | NA | chemical - endogenous mammalian | NA | 6.90e-01 | NA | 0.0e+00 | CDKN1A,CNNM2,HIF3A,MAG,MYOD1,MYOG,PTP4A2,RUNX2,SLC41A2,Slc41a3,TNFRSF11B,ZDHHC17 | 1112 (21) |
| THRAP3 | 1.50e-01 | transcription regulator | NA | 6.90e-01 | NA | 4.0e-02 | ADIPOQ,CA3,CCND1,HAS2,NR1D2,RUNX2 | NA |
| CST5 | NA | other | NA | 6.90e-01 | NA | 0.0e+00 | ABLIM1,ADRM1,AKAP12,ANXA2,ANXA5,ARHGAP29,ARHGEF2,ATP8B1,BLOC1S1,CAV1,CD44,CDH1,COL12A1,COPS7A,CORO1A,CYBRD1,DHX38,DKC1,DNAJB4,DOCK5,DRAP1,EDC3,EEF1D,EIF5B,ELK3,EMP3,EPN3,EZR,FHL1,GALNT5,GDA,GRAP,HNRNPC,HNRNPU,IQGAP2,KIF11,LIMD2,MAL2,MAP1B,MAP1S,MRM3,MSN,MYO10,NAV3,NCBP2,NDUFC2,NHP2,NOM1,NOP2,NPAS2,NR2F1,NRP1,NTHL1,PIP4K2A,PLS3,PPAN,PPIC,PRDX1,PRPF6,PUS1,RBM28,RNPC3,RTN3,RUNX1,RUNX2,S100A11,SH3TC2,SLC1A3,SNF8,SRSF1,SRSF4,STEAP1,SURF6,TBL3,TESC,VCAN,VIM,VPS36,VSNL1,VTI1A,VTI1B,WDR77,WNT16,ZFC3H1 | NA |
| ziritaxestat | NA | chemical drug | NA | 6.90e-01 | NA | 0.0e+00 | ABTB1,ADAMTS5,ALDH1A3,AMIGO2,C3AR1,CA9,DDIT4,GBP2,IFIT1,LPAR1,LTBP2,MTURN,MX1,OAS3,OASL,SGK1,STAC,TAGLN,USP18 | NA |
| CLTC | -3.80e-01 | other | NA | 6.90e-01 | NA | 3.0e-02 | CD74,CDKN1A,HLA-A,KDR | NA |
| cadmium chloride | NA | chemical toxicant | NA | 6.80e-01 | NA | 0.0e+00 | ANXA5,ARG1,CCND1,CDH1,CDH2,CRP,CRYAB,CXCL12,DNAJB1,EEF1D,FKBP5,FOXO1,GADD45A,GAPDH,GCLC,GSR,Gsta4,HIF1A,HSP90AA1,HSPA1A/HSPA1B,IGFBP6,LPAR1,MAFF,MCM7,Mt1,NFE2L2,OCLN,PDGFB,PFKFB3,PIK3C2G,PKM,SNAI1,TGFB1,VIM | 1396 (17) |
| NCOA1 | 3.00e-02 | transcription regulator | NA | 6.80e-01 | NA | 0.0e+00 | ABCA1,ADIPOQ,AGL,AHR,ALDOA,BPGM,BTG2,C3,Calm1 (includes others),CASP8,CCND1,CDKN1A,CELSR3,DBP,DIO1,EGR1,ERBB3,Esrra,FGF2,GJB2,HAS2,HIC1,HIF1A,IGF1,IL1RN,KDR,LPIN1,MAPK3,MTHFSD,NADK,NFKBIA,NR0B2,OLR1,PAWR,PPARD,PPARG,RFX1,RPL36,SERPINE1,SFTPB,SLC2A1,SREBF1,TLE1,UCP3,ZNF746 | 1412 (21) |
| green tea polyphenol | NA | chemical drug | NA | 6.80e-01 | NA | 0.0e+00 | ADIPOQ,ANXA1,CASP3,CASP8,CAV1,CDH1,CDKN1A,ICAM1,IGF1,MMP2,PIK3R1,PPARG,PTGS2,TGFB1 | 1446 (19) |
| ouabain | NA | chemical drug | NA | 6.70e-01 | NA | 3.0e-02 | ACTA1,ANXA5,ATP1A1,BCL2L1,BDNF,CDK2,CDKN1A,CLDN3,HIF1A,SLC6A5,TNFRSF10A,VIM,YWHAQ | NA |
| INSR | -3.10e-01 | kinase | NA | 6.70e-01 | NA | 0.0e+00 | ACADL,ACADS,ACO2,ACSL1,ACSL5,ACTA1,ACTN4,Akr1b7,ALDH1A1,ANKRD1,ARHGEF2,ARRDC3,ATF3,ATP1A1,ATP1B1,ATP2A2,BCL2A1,BMP4,C2,Calm1 (includes others),Ccl2,Ccl7,CCND1,CCND2,CD36,CD83,CDKN1A,CDKN2C,CERS6,CFL1,CITED2,CKMT1A/CKMT1B,COL6A3,CORO1A,CORO2B,COX4I1,COX6A2,Cox8b,CSTB,CXCR4,CYP1B1,DDR2,DEK,DHCR7,DLK1,DUSP1,EDN1,EGR1,EGR2,Esrra,FBLN1,FCGBP,FEM1A,FEN1,FHL1,FOXC2,FOXP3,GADD45A,GAPDH,GATA4,GCH1,GPAM,GSK3A,HHEX,HSD17B4,IDH1,IDH3A,IER3,IGF1,IKZF2,IL10RA,IL1RL1,IL2RA,IQGAP1,IRS1,ITGA5,KCNJ15,KIT,KLF10,KLF9,LAT2,LCP1,LDB2,LEPR,LGALS1,LPIN3,LSS,MAOB,MARCKSL1,MC4R,MCM7,MMP2,MSMO1,MVD,MVK,MYCN,MYH7,MYOM2,NDN,NDUFA1,NDUFB9,NDUFV2,NFE2L2,NR4A1,NR5A2,NTS,OGN,OLR1,PANK3,PDGFB,PDK4,PECR,PHLDA1,PITX2,PLAGL1,PNPLA2,PPARG,PPARGC1B,PRDM1,PRKCQ,PRKD1,RAB7A,RPS16,SALL4,SEC14L2,SELENOP,SEMA3A,SERPINE1,SFRP2,SIRT2,SIX4,SKAP2,SLC12A7,SLC20A1,SLC2A1,SLC44A1,SOCS3,SOX7,SREBF1,Srsf5,ST8SIA2,STAR,SURF6,TGFB1,THBS2,TLR2,TNNI1,TWIST1,UCP3,UHRF1,VCAM1 | 1515 (21) |
| BACH1 | 1.34e+00 | transcription regulator | NA | 6.70e-01 | NA | 1.0e-02 | CXCR4,DUSP1,FTL,GAPDH,GCLC,HCCS,HIF3A,IGF1,NDUFAB1,NDUFS7,PDK2,PDK4,PPARG,SLC25A15,SLC25A22,SLC25A6,SPP1,TIMM13,UCP3 | NA |
| sodium selenite | NA | chemical drug | NA | 6.70e-01 | NA | 3.0e-02 | BCL2L1,COX4I1,IKBKB,MYF5,MYF6,MYOG,PTGES,PTGS2,TBXAS1 | NA |
| RPA1 | -1.60e-01 | other | NA | 6.60e-01 | bias | 0.0e+00 | Abi3bp,FAM110B,FMOD,HSPA1A/HSPA1B,ITGA1,PCNX1,RASSF10,SNCAIP,TPD52L1 | 1050 (7) |
| RGS6 | -8.40e-01 | enzyme | NA | 6.60e-01 | NA | 0.0e+00 | CDH1,CDH2,GNB5,SERPINE1,SNAI1 | NA |
| ATG7 | 5.60e-01 | enzyme | NA | 6.60e-01 | NA | 0.0e+00 | ACSL1,ACTA2,BCL2L11,CASP3,Ccl2,CD44,CDH2,CLDN1,COL1A1,HIF1A,HK1,IFIH1,IKBKE,IRF3,IRS1,MAP1LC3A,MSR1,MYH7,NFKBIA,NR0B2,PDLIM1,PLIN3,PRKCD,S100A4,SLC2A1,SLC37A2,SNAI2,SOCS3,SREBF1,TEK,TGFB1,TLR4 | 1553 (18) |
| CLCA2 | -8.10e-01 | ion channel | NA | 6.60e-01 | NA | 0.0e+00 | CASP3,CASP8,CDH1,CDH2,CDKN1A,FN1,SNAI1,VIM | NA |
| MED13 | -5.50e-01 | transcription regulator | NA | 6.60e-01 | NA | 0.0e+00 | AACS,ACSM3,ANKRD1,BPGM,CD36,CIB2,ELN,FOXP3,GPD1,GPD2,KITLG,NR4A2,NTRK2,PGAM2,PHKA1,PPARG,PRKAR2B,PYGL,SLC37A2,TKT,TMEM45B | NA |
| MNT | NA | transcription regulator | NA | 6.60e-01 | bias | 0.0e+00 | ALDH1A1,ALDOA,ARHGAP45,ATP1B1,AXL,BCL6,BLVRB,CCND2,CD300LB,CD36,CD53,CYBB,E2F2,FBXO32,GADD45B,KLF10,KLF6,LEPR,LOXL2,PC,PGK1,SERPINH1,TMEM252 | NA |
| FSCN1 | -1.30e+00 | other | NA | 6.50e-01 | NA | 0.0e+00 | AXL,CXCL10,FN1,LOXL2,MITF,MMP2,SOX10,THBS1 | 1174 (19) |
| PLCG1 | -5.50e-01 | enzyme | NA | 6.50e-01 | NA | 4.0e-02 | CCND1,EGR1,ENO2,KDR,SERPINE1,SLC2A1,THBS1 | NA |
| BGLAP | NA | other | NA | 6.40e-01 | NA | 2.0e-02 | ADGRE1,CD74,CIITA,DLK1,NLRP3,PRDM16 | NA |
| topotecan | NA | chemical drug | NA | 6.40e-01 | NA | 0.0e+00 | ABCG1,ACSL1,AIF1,AKAP12,ARHGAP24,ARHGAP42,ARL6IP1,ASAP2,ASAP3,ATF3,ATP8B2,BCL2A1,BCL3,BIRC3,BRI3,BTG1,BUB1,C3,CAMK1D,Ccl2,CD200,CD276,CD83,CDKN1A,CEBPD,CITED2,CREB5,CSF1,CSMD1,CSTF1,CXCL10,DHDH,DUSP5,EDN1,EGR1,EGR3,EMB,ENG,ERBB3,FUBP1,FZR1,GADD45B,GCH1,HIF1A,HLA-DQA1,HSD17B8,HSF2,HSPA1A/HSPA1B,ICAM1,IL17A,IL17RA,IL1R1,IL7,IRF1,IRS1,ITGA2,JAK3,KDELR2,MAP1S,MAP2K4,MARCKSL1,MAT2A,MGAT2,MGST2,MIER2,MMP14,MYCN,MYH10,NECTIN3,NFATC4,NFKBIA,NINJ1,OAF,PHKG1,PLCB1,PLK1,PLK2,PLK3,PPM1A,PPP3CA,PRKAR2B,PRKCQ,PTGS2,RCBTB2,RELN,ROBO2,SELP,SLC2A1,SOCS1,SOCS3,SRSF3,TMEM170A,TNFRSF1B,TOP2A,TST,TUBB,UBE3A,UNC5D,USP1,ZFP36 | 1476 (19) |
| cytochalasin D | NA | chemical toxicant | NA | 6.40e-01 | NA | 3.0e-02 | ACTA1,ACTA2,CNP,COL2A1,ITGA11,MAG,MMP14,MMP15,MMP2,PTGS2,SLC9A3,SLC9A5,SOX6,TRPV4 | NA |
| bevacizumab | NA | biologic drug | NA | 6.30e-01 | NA | 0.0e+00 | ANGPT2,CDH1,CDH2,CXCL12,CXCR4,FN1,KDR,NRP1,SNAI2,VIM | 1157 (18) |
| thyroid hormone | NA | chemical - endogenous mammalian | NA | 6.30e-01 | NA | 0.0e+00 | ABCG1,ACSL5,ACTA1,AK4,ATP2A2,BCAR1,BDNF,BTG2,CCNA2,CCND1,CCNI,CDK2,CDKN1A,DAB1,DAD1,DDAH1,ECH1,EGF,EGR1,FZD6,G6PD,GCH1,GPD2,IGF1,IGFBP4,INHA,KCNA5,KLF3,KLF9,LPL,MAPK14,MAPK3,MYH6,MYH7,NTRK2,PER1,PIP4K2A,PLA2G2A,PLA2G5,PPM1A,RAB2A,RELN,S100A10,SEMA6B,ST14,STAT1,STAT5B,TCEA3,TECTB,UQCR10,VIM | 1491 (21) |
| cannabidiol | NA | chemical drug | NA | 6.30e-01 | NA | 0.0e+00 | BDNF,ENO2,FN1,HIF1A,ID2,NTRK2,PENK,PTGS2,S100B,SOCS3,TRPV2 | 1121 (17) |
| amiodarone | NA | chemical drug | NA | 6.30e-01 | NA | 1.0e-02 | AK4,BCKDHA,CA3,F3,FABP1,FADS2,ICAM1,LSS,MYH6,MYH7,PPARG,SLCO2B1,TAGLN | 1343 (22) |
| 12-(3-adamantan-1-yl-ureido) dodecanoic acid | NA | chemical reagent | NA | 6.30e-01 | NA | 2.0e-02 | BCL2L1,BCL2L11,BIRC3,CARD6,Casp12,CASP3,CASP8,DAD1,FADD,Naip1 (includes others),PYCARD,RIPK2,TNFRSF10A,TNFRSF11B,TNFRSF1B,TP53BP2,TP63,TRADD | NA |
| miR-10a-5p (and other miRNAs w/seed ACCCUGU) | NA | mature microRNA | NA | 6.30e-01 | bias | 3.0e-02 | CDH1,HOXD10,KLF4,SNAI1,USF2,VIM | NA |
| MMP14 | -8.90e-01 | peptidase | NA | 6.30e-01 | NA | 1.0e-02 | ATF3,CDH2,CDKN1A,CSPG4,DAPK1,GAP43,JAG1,MMP14,NNT,PTGS2,SDC1,SLCO2A1 | 1356 (20) |
| HTR1A | NA | G-protein coupled receptor | NA | 6.20e-01 | NA | 2.0e-02 | CDH1,CDH2,FN1,NOS1,VIM | NA |
| GCN2iB | NA | chemical drug | NA | 6.20e-01 | NA | 0.0e+00 | ACSL1,ACTG1,ALDOA,BCAT2,BPGM,Calm1 (includes others),CAMK2A,CAMK2D,CD36,COL3A1,COX4I1,COX6A2,ENO3,GAPDH,GPX7,ITGA2B,ITGB3,LPL,Mt1,MYH7,MYL2,MYL3,NDUFS7,NFE2L2,PDE5A,PKM,PLIN4,PPARG,PRKAB2,PSMD13,PYGL,SREBF1,TNNC1,TNNT2 | 715 (7) |
| prostaglandin A1 | NA | chemical - endogenous non-mammalian | NA | 6.10e-01 | NA | 2.0e-02 | BCL2L1,CDKN1A,GAD1,HSPA1A/HSPA1B,LPAR6,NFKBIA,PTGS2,SOAT1 | NA |
| Cdkn1c | 1.90e-01 | other | NA | 6.10e-01 | bias | 0.0e+00 | CCNA2,CDKN1A,CXCR4,EGR1,ITGB4,LGI4,MAL,Mbp,MPZ,Pmaip1,PMP22,PPP1R13B,SOX10 | 1048 (12) |
| PITX2 | -1.94e+00 | transcription regulator | NA | 6.10e-01 | NA | 0.0e+00 | ACAD8,ADH1C,ATP1A1,ATP1B1,CACNA1G,CCL21,CCND1,CCND2,CDH1,CDH2,COL8A1,COL8A2,CYP26B1,CYP2S1,DACH1,DACT2,DDIT4L,EGR1,FMO2,FOXC1,FOXC2,FOXO1,FZD2,FZD4,GAD1,GADD45A,GFOD2,GPX7,GRHPR,HCN4,IRF6,KCNJ11,KCNK2,KCTD1,LEF1,ME3,MSRA,NDUFB3,NDUFC1,NDUFC2,NDUFS7,NFE2L2,NR5A1,NXN,PITX2,PLOD2,SHOX2,SLC25A24,SNAI1,TBX3,TBX5,TFAP2B,TNFSF8,UCP3,VIM,WNT2,WNT2B,WNT5A,WNT6,WNT9A,ZEB2 | 1676 (26) |
| mir-130 | NA | microRNA | NA | 6.00e-01 | NA | 0.0e+00 | AIF1,AQP4,ARG1,Ccl2,CD86,DEPDC1,FGFR1,GADD45A,HOXA5,IL17A,IRF8,KDR,KLF4,MRC1,PTGS2,ROCK1 | 1318 (17) |
| calmidazolium | NA | chemical drug | NA | 6.00e-01 | NA | 2.0e-02 | EGR1,FN1,NCAM1,RSPO1,VCAM1 | NA |
| HERC3 | -1.50e-01 | enzyme | NA | 6.00e-01 | NA | 0.0e+00 | ANKRD1,CDH1,CDH2,TGFB1,VIM | 947 (18) |
| olanzapine | NA | chemical drug | NA | 6.00e-01 | NA | 3.0e-02 | ACKR2,AOX1,ATF3,BDNF,CHST3,CYSLTR1,DBP,HBA1/HBA2,HOMER1,IL2RB,KCNMB4,LRAT,NR4A1,NR4A2,NR4A3,PLA2G4A,PYGM,RELN,RGS2,SLC22A3,SLC38A1,THBD,TSHR,TSPAN8 | NA |
| PRAME | NA | other | NA | 5.90e-01 | NA | 1.0e-02 | BCL2L1,CDKN1A,CYP26B1,EIF2AK3,S100A4,TOP2A | NA |
| HA900 | NA | chemical reagent | NA | 5.90e-01 | NA | 5.0e-02 | KITLG,PTN,SELP,SOCS3 | NA |
| OGT | -8.10e-01 | enzyme | NA | 5.90e-01 | NA | 4.0e-02 | ACO2,ATP2A2,BCL2L1,Ccl2,CCND1,CDH1,CDKN1A,DUOXA1,ELOVL7,GAP43,GFAP,GLI1,GLI2,LBH,LPL,MMP2,NDUFC2,PLK1,PSMC1,PTCH1,SEMA4F,SKP2,SREBF1,THY1,TNC,TYMS,VIM | NA |
| clozapine | NA | chemical drug | NA | 5.90e-01 | NA | 0.0e+00 | BDNF,DHCR7,EGR1,GRIA2,GSK3A,HOMER1,HTR7,NR4A1,NR4A2,NR4A3,NTS,PEA15,PRDM16,PRKAR2B,PVALB,SGK1,SREBF1,SYP,WNT5A | 1376 (17) |
| STUB1 | 1.90e-01 | enzyme | NA | 5.90e-01 | NA | 1.0e-02 | ACTA2,CASP3,CCNA2,CDKN1A,CTSS,EZH2,FOXO1,GATA4,Gsta4,HSP90AA1,KDM3A,MAP3K14,NOS1,PARK7,RIPK3,RUNX1,SNCA,TAGLN,TGFB1 | 1654 (21) |
| NPPB | NA | other | NA | 5.90e-01 | NA | 4.0e-02 | CASP1,COL1A1,COL3A1,EBP,FN1,LSS,MSMO1,SMAD7,STAR,TGFB1 | NA |
| mir-205 | NA | microRNA | NA | 5.90e-01 | NA | 1.0e-02 | AXIN2,CDH1,EGLN2,ERBB3,PRKCE,RUNX2,VIM,ZEB2 | 1459 (27) |
| GPR37L1 | -1.98e+00 | G-protein coupled receptor | NA | 5.80e-01 | NA | 1.0e-02 | GLI2,MYCN,PTCH1,SMO | NA |
| SUPT16H | -1.30e-01 | transcription regulator | NA | 5.80e-01 | NA | 0.0e+00 | ACTA1,AMPD3,ARHGAP9,AXL,BMP3,CCND1,CDK2,CDKN1A,CPNE6,DLG3,DUSP5,EGR1,EXT1,HSPA1A/HSPA1B,ID2,IGFBP7,KCNF1,LOXL2,LYPLA1,MSN,MYOD1,MYOG,MYOM2,NEFL,NFAT5,NXT2,PFN1,PLEKHO1,POLR3G,PROS1,RXRG,SEC13,SGCA,SLC10A3,SLC1A4,TCEAL7,TMEM231,TNNI2,UNC5A | 657 (3) |
| DIO2 | -1.30e-01 | enzyme | NA | 5.80e-01 | NA | 0.0e+00 | ALDH1A1,Arxes1/Arxes2,ASPA,ATF3,ATP2A2,B3GNT5,CARMIL1,CCDC138,CNTN2,CYP1B1,DDIT4,DGKG,EGR1,GADD45G,GFRA1,GPX8,GREM2,HS3ST5,HSPA1A/HSPA1B,IER5,INHBA,KLF15,LIPG,LUM,MAG,MARCKSL1,MSR1,MYH2,MYH7,Naip1 (includes others),NR4A1,NR4A2,NT5C1A,NTS,OSR1,PENK,PI15,PTCH1,SBNO2,SCUBE1,SEMA7A,SLC10A6,SLC1A3,ST8SIA2,TSPAN18 | NA |
| FLI1 | -7.10e-01 | transcription regulator | NA | 5.80e-01 | NA | 1.0e-02 | Ccl2,CCND1,COL1A1,CSF1R,CXCL10,EGR1,FLI1,FOXO3,ID2,IL2RA,IMP4,INPP5D,ITGA2B,LOX,NEU1,RPL18,SNU13,TEK,TNC | NA |
| maslinic acid | NA | chemical - endogenous non-mammalian | NA | 5.80e-01 | NA | 0.0e+00 | ADAM17,ADIPOQ,BCL2L1,BTRC,CCND1,CCND2,CD44,CD47,CDH1,CDK6,CDO1,CFL1,DVL1,ETS1,FBXW5,FOXO3,IL2RG,ITGA3,MAPK14,MSN,PIK3R1,PNPLA2,PPARD,PPARG,PRKAR2B,PRKCB,PRKCE,PRKCI,PTGS2,PTPA,SLC1A3,SREBF1,TGFB1,THBS1,WNT5A | 1550 (20) |
| CD-38 inhibitor 78c | NA | chemical reagent | NA | 5.80e-01 | NA | 0.0e+00 | CXCL12,FBLN5,FGF1,FGF2,FGF9,GBP2,HGF,HLA-A,IGF1,PTGS2,SERPING1,VCAM1 | 672 (9) |
| dabrafenib | NA | chemical drug | NA | 5.80e-01 | NA | 0.0e+00 | ACTA2,GPNMB,MITF,NLRP3,PYCARD,TGFB1 | 857 (7) |
| dibenzoylmethane | NA | chemical toxicant | NA | 5.80e-01 | NA | 1.0e-02 | CCND1,CDKN1A,CYP1B1,PTGS2 | 1255 (17) |
| C8 | NA | complex | NA | 5.80e-01 | NA | 5.0e-02 | Ccl2,ICAM1,SELE,VCAM1 | NA |
| C7 | -8.00e-01 | other | NA | 5.80e-01 | NA | 5.0e-02 | Ccl2,ICAM1,SELE,VCAM1 | NA |
| BIRC5 | 6.00e-02 | other | NA | 5.80e-01 | NA | 0.0e+00 | BCL2L1,BGN,CASP3,CD53,CD74,CDKN1A,COL1A1,COL3A1,COL5A2,COL8A1,CXCL13,FBLN1,FBN1,FCGR2B,FLT3LG,FMOD,FN1,HLA-DQA1,IL2RG,ITGA5,LAMA4,LUM,MMP2,TP63,VEGFC,VIM,VWF | 1367 (19) |
| miR-223-3p (miRNAs w/seed GUCAGUU) | NA | mature microRNA | NA | 5.80e-01 | bias | 2.0e-02 | CCND1,FOXO1,FOXO3,IRS1,LMO2,NKX6-1,NLRP3,SOX6,STMN1,VIM | NA |
| MXD1 | -3.60e-01 | transcription regulator | NA | 5.70e-01 | bias | 1.0e-02 | AARSD1,ACO2,BCL6,BUB1,CCNA2,CCND2,CDK14,CENPF,CIITA,COQ9,EDN1,GCSAM,ITGA1,MRPS9,NAAA,NEDD9,NOP2,NOTCH4,PES1,RPS2,TOP2A,WDFY4 | NA |
| mir-15 | NA | microRNA | NA | 5.70e-01 | NA | 2.0e-02 | ALDH1A3,BTRC,Ccl2,CCND1,CCND2,CDK6,FGF1,FGF2,FOXO1,HSPA1A/HSPA1B,IFIT1,ISG15,MAPK3,MX1,PNPLA2,PNPLA3,PPARG,PTGS2,RECK,SREBF1,TIMP1,WEE1 | NA |
| sulfasalazine | NA | chemical drug | NA | 5.70e-01 | NA | 4.0e-02 | BCL2L1,CCND1,FOXP3,GZMB,ICAM1,IER3,NFKBIA | NA |
| miR-122-5p (miRNAs w/seed GGAGUGU) | NA | mature microRNA | NA | 5.70e-01 | bias | 0.0e+00 | AACS,ADAM17,ALDOA,ANK2,CERS6,EEF1A1,Foxp1,FUBP1,GALNT10,GPX7,NCAM1,NFATC2IP,NUMBL,OSMR,PALM,PKM,RABIF,SLC7A1,TMED3,TPD52L2,TRIB1,UBAP2,VIM | NA |
| NKX2-1 | NA | transcription regulator | NA | 5.60e-01 | NA | 0.0e+00 | AKTIP,BCL2A1,BDH1,BMP4,BTG3,CD74,CNMD,CYGB,DPP4,EDIL3,EMP2,ENC1,Gsta4,HCK,HLA-A,IER3,IGFBP6,IL7,KITLG,LEF1,LRG1,MIA,MMP2,MYBPH,NECTIN3,NKD1,PC,PCDHA4,PDGFRA,PDPN,PLP1,POLG,PRRX2,RAC2,RBPJL,RET,RNASE4,ROS1,SCARA3,SCN7A,SCNN1G,SEC14L2,SERPINB9,SERPINE1,SFTPB,SMAD7,SNAI1,SNAI2,SSBP1,Tcf7,TGFB1,THBS1,THY1,TNC,TOX,TP63,TPO,TSHR,UGT8,WNT11,WNT4 | 922 (10) |
| CDK8 | -3.20e-01 | kinase | NA | 5.60e-01 | NA | 1.0e-02 | CD44,CDH1,CTNNBIP1,CXCR4,DIO1,ESRRB,KLF4,KLF5,MAGI1,Podxl,RBL1,TBX3,TFCP2L1,UHMK1 | NA |
| trans-hydroxytamoxifen | NA | chemical drug | NA | 5.60e-01 | NA | 0.0e+00 | ABCC5,ACTN4,ACVR1,ADGRA2,ANGPT2,ARHGAP24,ARNT2,ASB9,BCAS1,BMP4,BTG1,CALCR,CAV1,CBX6,CCNA2,CHI3L1,CITED2,COL1A1,CTSH,CXCL12,CYBA,CYP1B1,DBN1,DCN,DDIT4,DUSP1,ECH1,EGR1,EGR3,ENC1,EPB41L3,ERBB3,FAP,FGF10,FGF9,FN1,GCLC,H2AC18/H2AC19,HIF1A,IER3,IGFBP4,IL1R1,INHBB,INPP5J,IRF6,ITGA2,KLF6,L1CAM,LHFPL2,LITAF,LOX,LOXL2,LOXL4,MATN2,MB,MMP2,MYBL1,NR2F2,PKD2,PLK2,PLOD2,PLXDC1,PPP1R3C,PTGER3,PVALB,PXDN,RAB30,RAB31,RAP1GAP,RND3,RSPO3,RUNX1,SELENBP1,SERPINB9,SERPINF1,SFRP1,SIAH2,SLC39A6,STAT1,THBS2,TM4SF1,TOP2A,TTC9,UNC5B,VEGFC | 1557 (18) |
| SERPINB7 | -3.00e-02 | other | NA | 5.60e-01 | NA | 3.0e-02 | ADAMTS15,ALKBH3,BMP1,C1R,CACNA1E,CACNB2,CACNB4,CALCRL,CASP1,CASP3,CCR1,CPQ,CTSC,CTSH,CX3CL1,DHH,GDF11,ICAM1,INHBA,INHBB,ITGA2,ITGB4,MMP14,NR4A1,PPP3CA,ROS1,TGFB1,TLL1,TRPV1,TRPV3,USP43 | NA |
| CRTC3 | 1.00e-01 | other | NA | 5.60e-01 | bias | 3.0e-02 | CREB5,Esrra,IDH3A,NR4A3,PDE4D,RGS2 | NA |
| RNF31 | 4.40e-01 | enzyme | NA | 5.60e-01 | NA | 2.0e-02 | C8orf44-SGK3/SGK3,Ccl2,Ccl6,Ccl7,CCND1,CXCL10,CXCL13,CXCL16,CXCR4,EGR3,IGFBP4,IL10RA,IL15RA,IL18BP,IL1RL1,IL1RN,IL2RG,IL33,NR5A2,STAR | NA |
| ARID4B | -3.10e-01 | transcription regulator | NA | 5.60e-01 | NA | 2.0e-02 | CLDN3,EMB,FOXP3,HOXB5,INHA | NA |
| largazole | NA | chemical - endogenous non-mammalian | NA | 5.60e-01 | NA | 2.0e-02 | ACSL5,DPP4,FGF2,GAPDH,HIF1A | NA |
| niacinamide | NA | chemical - endogenous mammalian | NA | 5.60e-01 | NA | 3.0e-02 | ACTA2,BCL2A1,CCNI,CDK18,CDKL2,CDKN1A,CITED2,CNNM2,CNNM3,COX4I1,CXCL12,FOXP3,G6PD,GAPDH,ICAM1,IRF1,KLF4,NFYA,NNMT,PDK4,PTGS2,RBL1,RUNX2,UBE2F | NA |
| IGF1R | -9.00e-02 | transmembrane receptor | NA | 5.50e-01 | NA | 0.0e+00 | ABCC4,ACADS,ACSL1,ACTA1,ACTA2,ACTN4,ADRB2,ALDOA,ANKRD1,AQP4,BCL2L1,BCL2L11,CALU,CBFB,CCND1,CD109,CD300C,Cd33,CD36,CD37,CD48,CD53,CD84,CD93,CDH1,CDKN1A,CETN2,COL18A1,COL1A1,COL3A1,COX4I1,COX6A2,Cox8b,DLK1,EDN1,EGR1,EMP1,FOXP3,GLI1,HIF1A,ID2,IGF1,IGFBP4,IGFBP5,IL16,IL17A,INHA,INHBA,INHBB,IRS1,IRS2,KRT19,LASP1,LPL,MAPK14,MYCN,MYH7,MYOD1,MYOG,MYOM2,NDN,NDUFA1,NDUFB9,NDUFV2,NR4A1,PECR,PKM,PLAT,PROM1,PTGS2,RFC2,RHOA,RPL37A,RPS24,RUNX2,S100A10,S100A4,Scd2,SDC4,SLC16A2,SNAI1,SPP1,SREBF1,STAR,TGFB1,TGFBI,TNNI1,TPO,TWIST1,TYMS,UCP3,VEGFC,ZFP36L2 | 1677 (24) |
| PTP4A1 | -2.00e-02 | phosphatase | NA | 5.50e-01 | NA | 0.0e+00 | ACTN4,ALDOA,ANXA5,B3GNT2,C1orf21,COL5A1,DNAJB1,EEF1A1,EEF1A2,EIF6,ELAVL1,FLNA,FLRT1,HIF1A,HRAS,HSPA1A/HSPA1B,IFI16,IGFBP7,ITGA4,ITGB4,KCNJ12,LAMA2,MAP2K4,MMP14,MMP2,MYADM,PIK3R1,PKM,PRDX1,PTP4A3,ROCK1,SPARC,SRSF3,STMN1,TAGLN2,TKT,VCAN,VIM | NA |
| 8-chlorophenylthio-adenosine 3’,5’-cyclic monophosphate | NA | chemical reagent | NA | 5.50e-01 | NA | 0.0e+00 | ACADS,ATP2A2,BCAT2,BCL2L11,BIRC3,CASP3,CD36,CDKN1A,CEBPD,CREM,DUSP1,IGF1,KCNH2,LPIN1,LPIN3,Mbp,Naip1 (includes others) | 1377 (20) |
| LPL | -1.51e+00 | enzyme | NA | 5.40e-01 | NA | 0.0e+00 | ACTA2,ADIPOQ,CASP3,CD36,CSF1,CX3CL1,FOXO3,HIF1A,ICAM1,IRS1,IRS2,LPL,MSR1,MYL2,PDK4,PNPLA2,PPARG,PRKAA2,SELE,SLC27A1,SLC2A1,TGFB1,THBS1,TIMP1,UCP3,VCAM1 | 1327 (22) |
| mir-322 | NA | microRNA | NA | 5.40e-01 | NA | 1.0e-02 | CCNA2,CDH2,FGF2,FGFR1,FN1,MYH7,SMAD7,VIM | NA |
| RASSF1 | 4.30e-01 | other | NA | 5.40e-01 | NA | 0.0e+00 | ALDH1A1,AMIGO2,BHLHE40,CASP3,CAV1,CAV2,CCNA2,CCND1,CCND2,CDH2,CDKN1A,COL13A1,CXCR4,DAB2,DACH1,EGR1,EMP1,EPB41L3,FGF2,KLF10,KLF4,LDB2,LITAF,MAP1B,MDK,MMP2,MRAS,PCDH7,PLK2,PROM1,PROS1,PTGS2,SAMD5,SELENOP,SPP1,TUBB | 1436 (22) |
| AEBP1 | -8.40e-01 | peptidase | NA | 5.30e-01 | NA | 0.0e+00 | ABCA1,ABCG1,ACTA2,Ccl2,CD36,PPARG | 1250 (12) |
| MYOD1 | -1.80e+00 | transcription regulator | NA | 5.30e-01 | NA | 0.0e+00 | ACSL5,ACTA1,ACTA2,ACTC1,ADCY7,ALDOA,ANKRD1,ANKRD2,ATP2A1,BCL2L1,BCL6,BIN1,BUB1B,CDK2,CDKN1A,CDO1,CENPF,CHRND,CKM,CRYAB,CXCL14,CYP2S1,DEPDC1,DUSP1,E2F2,ENO3,FNDC5,FSTL1,FYN,GADD45A,GADD45G,GREM2,HAS2,ID2,IFI16,IGF1,IGFBP5,KIF4A,KLF6,KNL1,LMNB2,MKI67,MMP2,MUSK,MYBPH,MYF5,MYF6,MYH2,MYH3,MYH6,MYH7,MYL1,MYOD1,MYOG,NCAPG,PAX3,PLEKHO1,PLK1,PMEPA1,PNMT,Ppfia4,PRDM16,PRIMA1,PRKAR2B,RAC2,RECK,RUNX1,RYR1,SCN4A,SDC2,SGCA,SIX1,SLC2A1,SMAD7,SNAI2,STAT1,TGFB1,TKT,TNNC1,TNNC2,TNNI1,TNNI2,TNNT1,TNNT2,TOP2A,UBA7,UCP3 | 1308 (21) |
| SF1 | NA | transcription regulator | NA | 5.30e-01 | NA | 0.0e+00 | ACTA2,CNN1,COL1A1,FN1,ICAM1 | NA |
| panobinostat | NA | chemical drug | NA | 5.30e-01 | NA | 0.0e+00 | BCL2L1,BCL2L11,CCND2,CDH2,CDK6,CDKN1A,CEBPD,CITED2,CRYAB,CXCL10,FLNA,FN1,KIT,MITF,MYCN,PDGFC,PTGS2,RASGRP2,RHOA,SERPINE1,TP63,TRPM1,VIM | 1184 (16) |
| 9Z,11E-octadecadienoic acid | NA | chemical - endogenous mammalian | NA | 5.30e-01 | NA | 0.0e+00 | CD36,EBF1,FABP1,FADS1,IL10RA,NFAT5,PPARG,PTGS2,SREBF1,THBS1 | 760 (13) |
| SHR2554 | NA | chemical drug | NA | 5.20e-01 | NA | 1.0e-02 | BCL2L1,CDK2,CDK6,CDKN1A,MKI67 | 462 (7) |
| chidamide | NA | chemical drug | NA | 5.20e-01 | NA | 2.0e-02 | BCL2L1,CDK2,CDK6,CDKN1A,MKI67 | NA |
| NODAL | NA | growth factor | NA | 5.20e-01 | NA | 4.0e-02 | ACTA2,ARG1,CCND1,CD34,CD86,CDK2,CXCL10,FOXO3,MRC1 | NA |
| butyric acid | NA | chemical - endogenous mammalian | NA | 5.20e-01 | NA | 0.0e+00 | A2M,ABCG1,ADGRE1,ADGRE5,AFF1,ALDH1A1,ALOX15,ALOX5,ALPK2,ANXA1,ANXA2,ANXA5,ATP2B4,BCL2A1,BCL2L1,CALB1,CASP3,CCNA2,CCND1,CCND2,CCR1,CCR3,CCR5,CD300C,CD36,CD44,CD83,CD86,CDH1,CDH11,CDK2,CDK6,CDKN1A,CETN2,CLCN3,CLDN1,COL11A1,COL5A1,COL5A2,COL6A3,CPA3,CSF1,CXCR4,DAPK1,DDR1,DEK,DNM1,DPP6,DUSP1,E2F5,ELK3,EMP3,FABP1,FIS1,FSTL1,FXN,FYN,G0S2,GADD45A,GATA4,GBP2,GCLC,GLI1,HBA1/HBA2,HDAC9,HK1,HLA-DRA,ICAM1,IFI16,IFIT1,IL17A,IL18BP,IL18R1,IL1R1,IL1RL1,INPP5D,INPP5J,IQGAP1,IRF1,IRS1,ITGA5,ITGB7,KIT,KLF4,KLF5,MAD1L1,MAPK4,MKI67,MPP3,MYCN,MYH14,MYH3,MYH7,MYL2,NEU1,NFATC4,NFKBIA,NPR1,NR4A1,NRP1,NUCB1,PDK2,PLAT,POU2F2,PPARG,PRDM1,PRDX1,PRKCB,PRKCD,PTAFR,PTGS2,PTPN7,PYGL,RBBP4,RBL1,RHOA,RXRA,SELENOP,SERPINE1,SGK1,SIPA1,SKP2,SLC2A1,SOCS3,SPP1,SREBF1,STAR,STAT5B,STAT6,SYK,TGFB1,TGFBI,THBS4,TIMP1,TLR2,TNFAIP2,TOP2A,TP53BP2,TRPV1,TWF1,TYMS,UTRN,WEE1,WNT5A,ZFP36L1 | 1717 (20) |
| torkinib | NA | chemical drug | NA | 5.20e-01 | NA | 0.0e+00 | ADAMTS1,AHR,ANKRD1,ATF3,BCL6,BTG1,C1R,CCND1,CCNE2,CD44,CDH1,CDK2,CYP1B1,DDIT4,DEPTOR,E2F2,EDN1,EGR1,EGR2,FEN1,FOXC1,FOXO3,GINS3,GREM2,HAS2,IL1RN,INHBA,ITGA2,KLF5,KLF6,KNL1,MTHFD2,NABP1,NCAPG,NR4A1,NR4A2,NR4A3,NUAK1,PMEPA1,POLA2,PTGS2,RFC2,RFC5,RGCC,SDC4,SGO2,SKP2,SMAD7,SMC2,SMOX,TMEM119,TOP2A,TYMS | 1580 (25) |
| fatty acid | NA | chemical - endogenous mammalian | NA | 5.10e-01 | NA | 0.0e+00 | ABCA1,ACADL,AHR,Ccl2,CD36,CREM,FADS1,FADS2,GPAM,HDAC4,IRS1,LEPR,LPL,MAFA,mir-143,MYOD1,MYOG,NFKBIA,NFKBIB,NR4A1,NR4A2,NR4A3,PLIN4,PPARD,PPARG,PRKAA1,PRKAA2,PTGS2,RXRA,SERPINE1,SLC27A1,SLC2A1,SREBF1,UCP3,VCAM1 | 1319 (20) |
| SH3KBP1 | 1.30e-01 | other | NA | 5.10e-01 | NA | 0.0e+00 | BCL2A1,BCL2L1,CCND2,CD86,CDH1,FN1,HIF1A,PRDM1,SERPINE1,SNAI1 | 1222 (20) |
| MALT1 | 0.00e+00 | peptidase | NA | 5.10e-01 | bias | 5.0e-02 | CD44,CD83,FOXO1,FOXO3,FOXP3,IKZF2,IL17A,IL2RA,IRF4,REL | NA |
| 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine | NA | chemical - endogenous mammalian | NA | 5.10e-01 | NA | 1.0e-02 | Ccl2,CD83,CD86,EGR1,F3,ICAM1,NR4A2,PTGS2,SELE,VCAM1 | 1289 (20) |
| FANCC | -4.20e-01 | other | NA | 5.10e-01 | NA | 0.0e+00 | ATP1B1,AXIN2,CDK11A,CXCL12,CYP7B1,FGFR1,FHL2,FZD2,FZD4,FZD6,GSAP,HHEX,HOMER1,IFI44L,IL1R1,JAG1,MAP1B,MX1,MYL1,MYOF,MYRF,NKD1,NUAK1,PRKCB,PROX1,PTGS2,PTPRC,PTX3,RND3,SFRP1,SKAP2,TBC1D9,WNT5A | 1419 (15) |
| TSC1 | 8.00e-02 | other | NA | 5.10e-01 | NA | 0.0e+00 | ALOX15,ATP6AP2,ATP6V0A4,ATP6V0B,ATP6V1A,AXIN2,CASP1,CRYAB,CTSK,DLG3,EGR2,ELOVL1,FLNA,FOXO1,FOXO3,FOXP3,GLRX,GLUL,GSR,IL17A,IRS1,IRS2,LAPTM4B,LDHB,LGR5,LITAF,MKI67,NEU1,NKD1,PDGFRA,RNF128,RPS6KB1,SREBF1,STAT1 | 1465 (20) |
| PIK3CG | -1.32e+00 | kinase | NA | 5.10e-01 | NA | 0.0e+00 | AIF1,ARG1,B2M,BCL2A1,BCL2L11,C2,CALCR,Ccl2,CD47,CD74,CTSK,CXCL10,CXCR4,EPHB6,FCGR3A/FCGR3B,GBP2,GBP4,GBP5,GBP7,HLA-A,ICAM1,IL17A,IL17RA,IL2RB,IRF1,ITGB3,KIT,LMO1,LSM4,MKI67,PIK3CG,SELE,STAT1,TGFB1,TLR2,TLR8 | 1429 (16) |
| aphidicolin | NA | chemical toxicant | NA | 5.00e-01 | NA | 2.0e-02 | CDKN1A,GADD45A,IFI16,IFI44L,IFIT1,MX1,MYH6,MYOG,STAT1 | NA |
| MTA3 | 4.60e-01 | transcription regulator | NA | 5.00e-01 | NA | 0.0e+00 | ACTC1,CDH2,CIITA,FN1,MYH6,PRDM1,SDC1,SNAI1,SYK,TGFB1,ZEB2 | NA |
| HDL | NA | complex | NA | 5.00e-01 | NA | 0.0e+00 | ABCG1,ADIPOQ,ATF3,Ccl2,CD86,CX3CL1,CX3CR1,EGLN1,GFAP,HIF1A,ICAM1,ITGB2,ITGB3,PTGIS,PTGS2,SELP,SIAH2,SREBF1,STAR,VCAM1 | 942 (15) |
| CIDEC | -8.10e-01 | other | NA | 5.00e-01 | NA | 0.0e+00 | ACADL,ACADS,Ccl2,COX4I1,Cox8b,EBF2,FOXC2,PLIN1,PNPLA2,PPARG,PPARGC1B,SDC1,SERPINE1,SREBF1 | 1486 (23) |
| honokiol | NA | chemical - endogenous non-mammalian | NA | 4.90e-01 | NA | 0.0e+00 | ADIPOQ,BCL2L1,CCND1,CCND2,CDH1,CDK2,CDK6,CDKN1A,ICAM1,IQGAP1,KDR,MAP1LC3B,PPARG,PTGS2,PTPN6,RETN,SNAI1 | 1176 (14) |
| methylmercury | NA | chemical toxicant | NA | 4.90e-01 | NA | 0.0e+00 | ACVR1C,ANPEP,BCL2L1,CASP3,CD47,CDK6,CHP1,CITED2,COL1A1,COL3A1,EGR1,ID2,LOC257642,Mt1,NOS1,PLD1,PLS3,PTPRF,SLC16A1,SLC1A1,SPARC,YWHAQ | 1026 (9) |
| mir-22 | NA | microRNA | NA | 4.90e-01 | NA | 2.0e-02 | ACTA2,CDH1,CDKN1A,CLIP2,EDC3,ERBB3,HDAC4,LEF1,MAPK14,MVK,RGS2,SNAI1,TP63 | NA |
| TFAM | 0.00e+00 | transcription regulator | NA | 4.90e-01 | NA | 2.0e-02 | ACADL,ACADS,AUH,BCL2A1,ECH1,GIMAP4,HK1,HS6ST2,ITGA5,LDHB,MAN1C1,MBOAT1,METRNL,PGK1,PKM,RNF43,RUNX2,SLC2A1,SLC2A10,STX11,Tnfrsf26,ZBTB16 | NA |
| IL16 | -6.40e-01 | cytokine | NA | 4.90e-01 | NA | 4.0e-02 | BCL2L1,CMA1,FOXP3,IL2RA,SKP2,TGFB1 | NA |
| eicosapentenoic acid | NA | chemical drug | NA | 4.90e-01 | NA | 0.0e+00 | ADIPOQ,BCL2L1,BDNF,CCR5,CD36,CD44,CD83,CD86,CEBPD,CSF1R,ECH1,ELN,FADS1,FADS2,FBN1,IGF1,IL17A,IL1R1,IL2RA,KCNJ11,MRC1,NFE2L2,PDK4,PNPLA2,PPARG,PROM1,PTGES,PTGS2,SELENOP,SERPINE1,SLC2A1,SNCA,SOAT1,SREBF1,TGFB1,TNFRSF1B | 1050 (20) |
| EHF | -5.20e-01 | transcription regulator | NA | 4.90e-01 | NA | 0.0e+00 | ALOX5,ANPEP,BMP4,CASP3,CCBE1,CDH3,COL2A1,GPR68,HOPX,IL1RN,JAG1,KDR,KIT,KLF5,LYN,MET,MS4A2,NOTCH2,PLAT,PPARD,SERPINE1,SPDEF,STAT5B,TGFB1,THBD,THY1,TIMP1,Tlr11,TNC,VEGFC,ZFP36L1 | 903 (7) |
| Rxr | NA | group | NA | 4.80e-01 | NA | 0.0e+00 | ABCA1,ADAM10,Akr1b7,BCL11B,BTG2,CD36,CDKN1A,CTSS,CYP4F2,DIO1,DLK1,EFNA5,GADD45A,GAS2,IGF1,ITGB2,MMP2,NR0B2,NR5A2,PAX3,PDGFB,PDK4,PLTP,PPARG,PTGS2,PTPRO,RXRA,SERPINF1,Slco1a4,SPP1,SREBF1,TPH1 | 1316 (24) |
| SFRP1 | -1.32e+00 | transmembrane receptor | NA | 4.80e-01 | NA | 3.0e-02 | ACTA2,CASP3,CCND1,CDH1,COL1A1,FN1,MMP2,RUNX2,SDC2,SERPINE1,SFRP1,SREBF1,Tcf7,TTYH1,VIM | NA |
| FKBP5 | 2.30e+00 | enzyme | NA | 4.80e-01 | NA | 0.0e+00 | ADIPOQ,ARG1,CCND1,CD36,CDC25B,CDK6,CDKN1A,E2F2,ICAM1,LPL,PDK4,PRDM16,SLC2A1,TEF,TM2D2 | 1414 (15) |
| benzene | NA | chemical toxicant | NA | 4.80e-01 | NA | 0.0e+00 | ACVR1C,ANPEP,BCL2L1,CASP3,CD47,CDK6,CDKN1A,CHP1,CITED2,COL1A1,COL3A1,EGR1,ID2,LOC257642,PLD1,PLS3,PTPRF,SLC16A1,SPARC,YWHAQ | NA |
| Gm21596/Hmgb1 | NA | transcription regulator | NA | 4.80e-01 | NA | 1.0e-02 | CDKN1A,CXCL12,CXCR4,HIF1A,HOXD9,IL1RL1,PKM,PROM1,SIGIRR,TLR4 | 1030 (13) |
| CD200 | -1.13e+00 | other | NA | 4.80e-01 | NA | 1.0e-02 | CTSK,FOXP3,ITGAL,MET,MRC1,MYF5,PAX3,TLR2,TLR4 | 1057 (12) |
| FOXD3 | NA | transcription regulator | NA | 4.80e-01 | NA | 4.0e-02 | CDKN1A,CXCR4,EZH2,RND3,SKP2 | NA |
| beraprost | NA | chemical drug | NA | 4.80e-01 | NA | 1.0e-02 | CD86,COL1A1,COL3A1,CREM,EDN1,FN1 | 550 (7) |
| AMP | NA | chemical - endogenous mammalian | NA | 4.80e-01 | NA | 1.0e-02 | ACTG1,FOXO1,IRS2,KLF3,PIK3R1,SELP,SLC25A25 | 562 (7) |
| miR-293-5p (and other miRNAs w/seed CUCAAAC) | NA | mature microRNA | NA | 4.80e-01 | bias | 5.0e-02 | FGF16,KLF15,MADD,MGST1,NR4A1,TAGLN,VSNL1 | NA |
| IL6ST | -5.10e-01 | transmembrane receptor | NA | 4.80e-01 | NA | 0.0e+00 | A2M,ATP2A2,BCL2L1,CASP1,Ccl2,CCND1,CD44,CSF1R,CXCL13,EGR1,GFAP,IL17A,IL7,IRF1,MAF,NLRC4,RET,SERPINE1,SGCA,SOCS1,SOCS3,TIMP1,TNFRSF1B,VCAM1 | 1202 (17) |
| EGLN | NA | group | NA | 4.70e-01 | bias | 4.0e-02 | A2M,AK4,ANKRD2,ANKRD9,APLN,BCKDHA,BCL11B,CA9,Ccl2,CSRP2,EGLN1,EGLN2,EIF4EBP1,ERFE,FTL,FYN,GAPDH,GPI,GREM2,GRHPR,IKBIP,MYOCD,NTS,PAM,PDGFRL,PGK1,PGM1,PYGL,RNASE4,SAP30,SELENBP1,SERPINE1,SLC16A3,SLC27A1,SMTNL2,TNFAIP6 | NA |
| BNIP3L | -5.00e-01 | other | NA | 4.70e-01 | NA | 0.0e+00 | ANK1,BCL2L1,Ccl2,CCNA2,CCNE2,CD22,CD47,CENPF,GADD45A,GAPDH,GPSM2,IL16,IL2RB,KIF11,MAP4K1,NFKBIA,PFKFB3,PKM,RBL1,SFRP1,SGO1,SYK,TFDP2,TGFB1,TOP2A | 1064 (12) |
| MZF1 | 0.00e+00 | transcription regulator | NA | 4.70e-01 | NA | 0.0e+00 | AXL,CD34,CDH2,FGF2,MS4A2,NOS1,TGFB1 | NA |
| Proteasome | NA | complex | NA | 4.70e-01 | NA | 2.0e-02 | HIF1A,JUND,NFKBIA,SREBF1 | NA |
| AGTR1 | -4.60e-01 | G-protein coupled receptor | NA | 4.70e-01 | NA | 0.0e+00 | CASP3,CCND1,COL3A1,CP,CYBA,DUSP1,EDN1,FN1,HGF,MGST1,OLR1,PTGS2,RHOA,SERPINE1,SGK1,TGFB1 | 1170 (21) |
| staurosporine | NA | chemical drug | NA | 4.70e-01 | NA | 0.0e+00 | ANXA5,BCL2L1,BTG2,CASP3,Ccl6,CCND1,CCR3,CD28,CD53,CDKN1A,CKM,COL1A1,CPNE3,CSF3R,ERBB3,HDC,ICAM1,IGF1,IGFBP5,INHBB,ISG15,ITGB2,ITGB3,KLF10,MICB,MME,MMP2,NCF1,NEDD9,NR4A1,PLAT,PRDM1,PRDX1,PTGS2,RPS11,SELE,SERPINE1,STAR | 1145 (16) |
| PRKAA | NA | group | NA | 4.60e-01 | NA | 0.0e+00 | Ccl2,CCND1,CD36,CDH1,CDKN1A,CLDN1,CXCL10,DUSP1,FKBP5,FOXO3,HDAC4,MYOG,NCF1,NCF2,SNAI1,SREBF1,STAR,STAT1,TMPRSS2,VIM | 1358 (19) |
| tanshinone II | NA | chemical - endogenous non-mammalian | NA | 4.60e-01 | NA | 0.0e+00 | ABCA1,ABCG1,ATF3,BCL2L1,BDNF,CDK2,EDN1,GJB2,ICAM1,mir-133,MMP14,MMP2,MSR1,SKP2,TLR4,VCAM1,XYLT1 | 1141 (17) |
| colistin | NA | biologic drug | NA | 4.60e-01 | NA | 0.0e+00 | ABCC3,ABI1,AGMO,AK1,ALCAM,APOD,BACH1,BMP1,BMP4,CCND1,CD9,CITED2,CRYL1,CSF1,DNAJB4,EXTL3,GPM6A,IGFBP5,IL10RA,KHDRBS3,LAMP2,LGALS1,MCOLN1,MMP2,NUAK1,PTPRZ1,RHOA,RTN4RL1,SLC7A8,SLCO4A1,SPP1,ST3GAL6,SYNJ1,TMC7 | NA |
| NR5A1 | 2.24e+00 | ligand-dependent nuclear receptor | NA | 4.60e-01 | NA | 1.0e-02 | ADCY4,Akr1b7,AMHR2,ANGPT2,CYP26B1,ETS1,Giot1/Zfp347,INHA,KIT,LEPR,MC2R,NOS1,NR0B2,NR2F1,NR4A2,NR5A1,NR5A2,PNMT,STAR,VIM | 1835 (16) |
| pinometostat | NA | chemical drug | NA | 4.60e-01 | NA | 0.0e+00 | ARID3B,CDKN1A,CHST11,CIITA,CST7,CXXC5,EZH2,GPT2,HLA-DRA,IGF1,LAPTM4B,PBX3,PDK4,SLC4A3,SMAD7,SNAI1,TWIST1 | 1171 (19) |
| FAT1 | -3.60e-01 | other | NA | 4.60e-01 | NA | 1.0e-02 | CD44,KLF4,MET,PTGS2,SNAI1,TGFB1,TWIST1,VEGFC,VIM,ZEB2 | 1291 (13) |
| TARDBP | NA | transcription regulator | NA | 4.50e-01 | NA | 1.0e-02 | AIF1,BCL2L11,C3,CASP3,Ccl2,CD36,CSPG4,CYBA,DHCR7,EBP,FIS1,GBP2,HIF1A,HLA-A,IGFBP5,LRG1,LRRN1,LSS,MAG,mir-143,MOG,MVD,MVK,PLP1,PRKDC,PTPRZ1,RPS6KB1,SERPING1,SFRP1,SFRP2,STAT6,WNT5A | 629 (9) |
| FGFR4 | -1.60e-01 | kinase | NA | 4.50e-01 | NA | 0.0e+00 | BCL2L1,CCND1,CD44,CDH1,CDH2,CDKN1A,FGFR1,KDR,LPAR1,LPL,MMP14,NR0B2,SERPINE1,SNAI1,SREBF1,TGFB1,TWIST1 | 1332 (20) |
| edratide | NA | biologic drug | NA | 4.50e-01 | NA | 0.0e+00 | CD44,EGR2,EGR3,FOXO3,ITGAL | NA |
| DKC1 | 9.20e-01 | enzyme | NA | 4.50e-01 | bias | 0.0e+00 | Ccl2,COL3A1,FGF2,SERPINE1,VIM | NA |
| FRS2 | -4.70e-01 | other | NA | 4.50e-01 | NA | 1.0e-02 | ACTA2,BMP4,CD44,ITGA6,PROM1,TAGLN | NA |
| LINC01139 | NA | other | NA | 4.50e-01 | bias | 2.0e-02 | ALDOA,BHLHE40,EGR1,PKM,SLC16A3 | NA |
| GFPT1 | 2.40e-01 | enzyme | NA | 4.50e-01 | NA | 2.0e-02 | HAS2,PPARG,TGFB1,THBS1,USF2 | NA |
| SART1 | 6.10e-01 | other | NA | 4.50e-01 | NA | 2.0e-02 | CA9,DDIT4,HIF1A,PROM1,SERPINE1 | NA |
| AZ-1 | NA | chemical - protease inhibitor | NA | 4.50e-01 | NA | 3.0e-02 | AARSD1,ANXA8/ANXA8L1,ATP8B1,BCKDHA,CD109,ERAP1,FN1,GNPDA2,ITGB4,MME,PDLIM7,PKP3,RASSF9,RND3,RP2,SLC37A4,SNX3,TGFB1I1,THBS1,TMEM123 | NA |
| creatine | NA | chemical - endogenous mammalian | NA | 4.50e-01 | NA | 4.0e-02 | CKMT1A/CKMT1B,CXCL10,GATM,MYH2,TLR2,TLR4,TLR7,TNNT1 | NA |
| embelin | NA | chemical - endogenous non-mammalian | NA | 4.40e-01 | NA | 4.0e-02 | BCL2L1,CCND1,CDK2,CDK6,PPARG | NA |
| NKX2-3 | NA | transcription regulator | NA | 4.40e-01 | NA | 0.0e+00 | ACTA2,AIF1L,ANGPT2,ANKRD55,ARHGDIB,ASNS,BMP4,BTG1,CASP1,CD34,CD36,CDKN1A,CHST7,CRYAB,CSRNP1,CX3CL1,CXADR,CXCL16,DHX58,EDN1,EMCN,F2RL1,F2RL3,FBN2,FGF2,FLRT2,GBP2,GCA,GCH1,GIMAP7,H2AC18/H2AC19,HEY2,IL18BP,KLF4,MAMDC2,MAP2,MCTP1,MEDAG,MMRN1,MTURN,MYO5A,NR2F1,PARP14,PARP9,PAWR,PHGDH,PIM3,PLA1A,PLCB1,PLD1,PLEKHA4,PNPT1,Podxl,PRSS12,PTGS2,RNF213,RPL23,RTP4,SEMA3A,SHOX2,SLC25A28,SMAD7,SNCAIP,SP110,SRPX2,STAT1,TFPI2,TIPARP,TNFSF18,TRPC6,UACA,UBA7,UBE2L6,UCP3,UNC5A,UNC93B1,USP18,VCAM1,ZC3HAV1 | 875 (7) |
| GPBAR1 | NA | G-protein coupled receptor | NA | 4.30e-01 | NA | 1.0e-02 | ADGRE1,Ccl2,CCND1,CD86,CFL1,CHAC1,GCLC,GPX7,GSR,Gsta4,ICAM1,MGST1,SELE,VCAM1 | 1312 (13) |
| TNFRSF8 | -1.43e+00 | transmembrane receptor | NA | 4.30e-01 | NA | 4.0e-02 | ALDH18A1,CASP1,CDKN1A,CTSC,CXCR4,GBP2,GCLC,GZMB,IFI16,IRF4,LCP2,PBX3,PCDH7,PDPN,TNFRSF25,TNFRSF8 | NA |
| MGAT1 | -1.00e-02 | enzyme | NA | 4.30e-01 | NA | 0.0e+00 | ACTA2,CDH2,CLDN1,ITGA3,ITGA5,ITGB3,ITGB4,VIM | 1287 (15) |
| MFGE8 | -3.00e-02 | other | NA | 4.30e-01 | NA | 0.0e+00 | Ccl2,CCND1,CDH2,COL1A1,COL3A1,EDIL3,FGF2,MYH7,RHOA | 1347 (19) |
| ARRB2 | -4.00e-01 | other | NA | 4.20e-01 | NA | 0.0e+00 | ADRA2A,ADRB2,ATP2A2,Ccl2,EGR1,F3,GRK5,HIF1A,MMP2,PLA2G4A,PTGS2,SERPINE1,STAT1,TGFB1 | 907 (15) |
| 3M-002 | NA | chemical reagent | NA | 4.20e-01 | NA | 1.0e-02 | Abi3bp,ACTC1,BANK1,BCL2A1,CCND1,CD83,CD86,CFH,CXCL10,ESM1,ETV5,FCGR1A,FCMR,GABRR1,GCGR,GJA5,GPNMB,IFI44,IL18BP,IRF4,KLF5,LHFPL1,Milr1,MOG,MUSK,NCF4,PTGS2,RGS4,RP1,SPRY4,Tlr13,TLR8 | 855 (16) |
| TFRC | 4.00e-02 | transporter | NA | 4.20e-01 | NA | 0.0e+00 | ACTA2,ANXA2,ATF3,BCL2L11,CASP3,CCNA2,CDKN1A,CHAC1,COL1A1,DDIT4,ERFE,F13A1,FAM20C,FTL,GADD45A,GAS7,GPX3,GPX7,HERPUD1,ID2,ITGB2,KIT,LRRC25,LY75,MS4A6A,PFKFB3,PHGDH,Pmaip1,PPARG,PTN,SERPINB8,SLC2A1,SNCA,SULF2,UBE2E1 | 592 (7) |
| diclofenac | NA | chemical drug | NA | 4.20e-01 | NA | 0.0e+00 | ABCC4,AQP4,ASNS,ATF3,BACH1,BCAT1,CCND1,CDKN1A,CRP,DNAJB1,EIF4EBP1,HERPUD1,HIF1A,IL2RA,JAG1,JUND,KLF4,KLF9,LBH,MAP1LC3B,MTHFD2,OSMR,PTGS2,SERPINE1,SLC16A1,SLC2A1,SLC38A2,SLC7A1,VEGFC | 1275 (23) |
| T-5224 | NA | chemical reagent | NA | 4.20e-01 | NA | 0.0e+00 | ACSL1,ADAMTS1,ADAMTS9,ARID5B,BDNF,BEST1,CREB5,DUOX2,DUSP6,EBP,EGR1,EPB41L4B,F3,FAM104A,FKBP5,FLRT2,GADD45B,HAS2,ID2,IFI16,INHBA,IRS2,LMCD1,LSS,MAPK14,MAT2A,MVD,MVK,NR1D2,NUDT16,PDLIM1,PFKFB3,PHLDA1,PRICKLE2,PRKX,PRRG1,PTGES,PTGS2,PTX3,RAB11FIP3,RAPH1,RGS2,RUNX1,SLC2A1,SLCO2A1,SOCS3,TFPI2,TMEM164,TMX4,TRIB1,USP11 | NA |
| dacinostat | NA | chemical drug | NA | 4.20e-01 | NA | 4.0e-02 | ANGPT2,BCL2L1,CDKN1A,CEBPD,HIF1A,TEK,TNFRSF10A | NA |
| APC | 3.10e-01 | enzyme | NA | 4.10e-01 | NA | 0.0e+00 | AMHR2,APCDD1,AXIN2,B2M,CCND1,CCND2,CD44,CDH1,CDH2,CDH3,CDK6,CDKN1A,CLDN1,COL12A1,CXCL12,DHRS9,DPP4,EDN1,FGF10,GLI1,GLI2,GLUL,HIF1A,ICAM1,ID2,IDH3G,IGF1,IGFBP5,IL17A,ITGA2,ITGB3,JAG1,KLF4,LAMA3,LGR5,LPL,NOTCH2,NUMBL,OCLN,PDK2,PDK4,PLA2G4A,PPARD,PRKCB,PRKCZ,PTGS2,RFNG,SGK1,SNAI1,SNAI2,SPP1,TBX3,Tcf7,TEKT1,THBS1,TIMP1,TNFRSF11B,TNFRSF19 | 1532 (20) |
| tazemetostat | NA | chemical drug | NA | 4.10e-01 | NA | 0.0e+00 | ABCC4,ADAMTS1,ANKRD1,B3GNT2,BAIAP2,BCAT1,BCL11A,BDNF,BMP5,CCND1,CCND2,CD44,CDH1,CDH2,CDK5R1,CDK6,CREB1,CUX1,DDR2,DDX6,DEK,DLC1,E2F5,E2F8,ELF4,EMX2,EPHA3,EZR,FEZ1,FGF2,FGFR1,FLRT3,FN1,FOXC1,FUBP1,GAP43,GLI2,INPP5F,KCNMB4,KIF5C,KLF4,L1CAM,LEF1,LGALS1,LGR5,LOX,LTBP1,MAP1S,MAP2,MET,MICALL2,MOB2,MSI1,MSN,NCAM1,NEFL,NEK6,NR4A2,OGT,OLFM1,OSTN,PLCB1,PLK2,POLE3,PON2,PREX1,RET,SDC2,SEMA3C,SGK1,SIAH2,SLC38A1,SLC7A1,SMO,SMYD2,SPP1,SRSF1,STAG1,STAT5B,STAT6,STEAP2,TACC3,TNC,TWIST2,TYRO3,UBXN1,UNC13A,USF2,VCAN,WDR77,XPO1,ZFP64,ZFYVE27,ZSWIM6 | 977 (13) |
| STOCK2S 26016 | NA | chemical reagent | NA | 4.10e-01 | NA | 0.0e+00 | CDH1,CDH2,CLDN3,OCLN,SNAI1 | 382 (7) |
| PHLPP2 | -1.40e-01 | enzyme | NA | 4.10e-01 | NA | 2.0e-02 | ADIPOQ,IRS1,MAP1LC3B,MMP2,PRKCB,PRKCD,PRKCE | NA |
| CCN6 | NA | growth factor | NA | 4.10e-01 | NA | 0.0e+00 | ADAMTS5,BMP4,CDH1,ICAM1,SNAI1 | 1327 (20) |
| S-nitrosoglutathione | NA | chemical toxicant | NA | 4.10e-01 | NA | 0.0e+00 | BCL2L1,BIRC3,CD86,CDKN1A,CNR1,CXCL10,FOXP3,GFAP,HIF1A,HLA-DRA,ICAM1,IGF1,IRS1,IRS2,NFKBIA,PPARG,PTGS2,S100A10,SELE,VCAM1 | 1451 (18) |
| LCK | -7.00e-02 | kinase | NA | 4.10e-01 | NA | 0.0e+00 | ABCA1,ABCG1,ANXA1,BCL2L1,CCNA2,CISH,CSNK2B,DKC1,EGR1,EIF6,FOXP3,GADD45B,IL2RA,IL2RB,IRF1,ITGAL,ITGB2,NHP2,NOTCH2,PLCG2,POP5,PPARG,PRKCQ,RUNX1,SKP2,TCOF1,XPO1 | 1346 (22) |
| ciglitazone | NA | chemical drug | NA | 4.10e-01 | NA | 0.0e+00 | ABCA1,ABCG1,ACTA2,ACTC1,BCL2L1,CAV1,CAV2,Ccl2,CCND1,CD34,CD36,CDK2,CDKN1A,CIITA,CSPG4,CYBB,FN1,GFAP,GPD1,HGF,HLA-DRA,ICAM1,KIT,MITF,MMP2,MYOD1,NFKBIA,NFKBIB,NOX1,NOX4,NR5A2,OLR1,Podxl,PPARG,PTGS2,SELE,SERPINE1,SFRP2,SLC9A1,VCAM1 | 1129 (16) |
| TCF12 | -1.90e-01 | transcription regulator | NA | 4.00e-01 | NA | 0.0e+00 | ACOT8,CACNG4,CBFA2T3,CD200R1,CD93,CDH1,CDK20,CDKN1A,CSF1R,ELF4,ETS1,FLT3LG,FN1,FOXO1,GJB2,GLUL,ID2,IKZF2,IL10RA,IL18R1,IL1RL1,IL2RB,IL7,IRF1,IRF4,ITGA4,ITGB7,KLF6,MAF,MVD,NR4A3,PPARG,PPIA,RARG,RXRA,SEMA4A,SEMA7A,THY1,TNFRSF25,TNFRSF8,VIPR2,ZBTB16 | 710 (11) |
| arginine | NA | chemical - endogenous mammalian | NA | 4.00e-01 | NA | 3.0e-02 | AXL,BCL2L1,CXCL10,DDIT4,EGR1,GCH1,HDC,HIF1A,IGF1,PIK3R1,PTGS2,TGFB1 | NA |
| CERS2 | -1.90e-01 | transcription regulator | NA | 4.00e-01 | NA | 4.0e-02 | ABCC4,CDKN1A,CERS4,CERS6,SMPD3 | NA |
| vatalanib | NA | chemical drug | NA | 4.00e-01 | NA | 0.0e+00 | ACTA2,BCL2L1,CCND1,CDKN1A,COL1A1,CXCL12,HIF1A,KDR,TIMP1 | 1378 (19) |
| GATA3 | -9.00e-01 | transcription regulator | NA | 4.00e-01 | NA | 0.0e+00 | BATF,BCL11A,BCL11B,BCL2L1,BLVRB,CCND1,CCR1,CCR3,CCR5,CDH1,CDH2,CDKN1A,CDKN2C,CPA3,CSF1R,CXCR4,DTX1,EBF1,ELOVL1,ELOVL4,ETS1,FN1,FOXP3,FSCN1,GLUL,HIF1A,ICAM1,IL17A,IL1RL1,IL2RA,IL2RB,IRF6,ITGAE,ITGAL,KIT,KLF4,LOX,MAF,MYO10,NFIL3,NOTCH2,NR5A2,PPARD,PPARG,RET,RGCC,RPS6KB1,RUNX1,SERF1A/SERF1B,SGPP1,SLC2A1,SP110,STAT6,TAL1,TBX3,Tcf7,TEK,TGFB1,VCAM1,VIM,VSIR,WDR37,WNT11,ZBTB16,ZBTB7B,ZEB2 | 1499 (20) |
| TRIM37 | 1.00e-02 | enzyme | NA | 3.90e-01 | NA | 0.0e+00 | CA12,CDH2,CLDN1,DDR1,EGR1,MKI67,MYH7,PARP9,PAWR,PEX5,RARA,RASSF5,RASSF9,RET,SFRP1,SNAI1,TGFB1,TNNT2,VIM,WNT10B | 1450 (20) |
| mimosine | NA | chemical drug | NA | 3.90e-01 | NA | 1.0e-02 | CDKN1A,CIITA,CSNK2B,HLA-DQA1,RXRA,SHMT1 | NA |
| ARID4A | -3.00e-02 | transcription regulator | NA | 3.90e-01 | NA | 2.0e-02 | CLDN3,EMB,FOXP3,HOXB5,INHA | NA |
| KN-62 | NA | chemical drug | NA | 3.90e-01 | NA | 0.0e+00 | ATF3,CCND1,EGR1,IL17A,KCNJ11,MYH2,MYH7,MYOG,PPARG,PTGS2,VCAM1 | 912 (16) |
| L-methionine | NA | chemical - endogenous mammalian | NA | 3.90e-01 | NA | 0.0e+00 | ACTA2,ASNS,BDNF,BTG1,BUB1,CDKN2C,DDIT4,EEF1A1,EEF1D,F3,GADD45B,IFI16,IGFBP4,MAT2A,NFKBIA,PLAT,PRC1,PTGS2,SMAD7,SPP1,TOP2A,TYMS | 1526 (20) |
| tetrathiomolybdate | NA | chemical drug | NA | 3.80e-01 | NA | 0.0e+00 | ACTA2,COL1A1,IL2RA,S100A13,SERPINE1,TIMP1,VCAM1 | 1537 (14) |
| LRAT | -1.21e+00 | enzyme | NA | 3.80e-01 | NA | 0.0e+00 | CCNA2,CDKN1A,HGF,PDK4,PPARD,RBP7,TGFA | 696 (7) |
| (+)-fluprostenol | NA | chemical drug | NA | 3.80e-01 | NA | 0.0e+00 | FGF2,NOX1,NR4A2,PPARG | NA |
| mir-365 | NA | microRNA | NA | 3.80e-01 | bias | 1.0e-02 | ANK2,C8orf44-SGK3/SGK3,CAV1,CKM,MYF6,MYOD1,MYOG | NA |
| biochanin A | NA | chemical toxicant | NA | 3.80e-01 | NA | 2.0e-02 | ACP5,CD86,CXCL10,PTGS2,RHOA,RUNX2,TGFB1,TNFRSF11B | NA |
| harmine | NA | chemical - endogenous non-mammalian | NA | 3.80e-01 | NA | 3.0e-02 | ACTA2,BCL2L1,BDNF,COL1A1,MMP2,PTGS2,RUNX2 | NA |
| prazosin | NA | chemical drug | NA | 3.80e-01 | NA | 4.0e-02 | ALOX15,AQP4,DUSP1,EGR1,GFAP,NR4A1,PER1 | NA |
| fenofibrate | NA | chemical drug | NA | 3.70e-01 | NA | 0.0e+00 | ACADL,ACSL1,ACSL3,ACSL5,ADIPOQ,ASNS,BCL2L11,BMP15,Ccl2,CCL21,CCND1,CD200,CD36,CDH2,COL1A1,CRP,CSF1R,ECH1,EDN1,FABP1,FADS2,FBP2,FBXO32,GADD45A,GAPDH,GBE1,GLUL,GNB4,GPAM,Gsta4,HIF1A,HSD17B4,ICAM1,ID2,IRF8,KDR,LCAT,Ldha/RGD1562690,LDHB,LPL,MAN1A1,MITF,MSTN,MYH7,PDK4,PIK3C2G,PIK3R3,PLTP,PNPLA2,POPDC3,PPIC,PSMA4,PTAFR,PTGS2,PTPRC,PTPRF,RETN,SERPINE1,SLC27A1,SLCO2B1,SREBF1,STAR,TGFB1,TIMP1,TRIM63,UCP3,UGT1A4,VCAM1 | 1585 (25) |
| Cdc42 | -2.60e-01 | enzyme | NA | 3.70e-01 | NA | 0.0e+00 | ACTA2,ADAM10,AKAP7,ATP6V1A,CASP1,Ccl2,CD86,COL2A1,CSF1,CTSH,CTSS,DDAH1,DKC1,EIF4EBP1,EMP2,ETV5,FADS3,FGF2,FLNA,GFAP,LAMP2,LGR5,NHP2,PHGDH,PMP22,RPS6KB1,SDC1,SH2D4A,STMN1,SULF2 | 1090 (19) |
| FGFR3 | -5.00e-02 | kinase | NA | 3.60e-01 | NA | 0.0e+00 | BCL2L1,BMP4,CCND1,CDH1,CDKN1A,COL1A1,COL3A1,DLL1,DUSP6,FRMD3,GFAP,MAF,PROX1,SNAI1,SPARC,SPP1 | 1317 (18) |
| MECOM | NA | transcription regulator | NA | 3.60e-01 | NA | 0.0e+00 | BCL2L1,CA3,CDKN1A,DCN,GADD45G,ITGA2B,ITGA6,ITGB3,ITGB4,MAP3K14,SCUBE3,SERPINE1,SPARC,ZFPM2 | 674 (7) |
| GABA | NA | chemical - endogenous mammalian | NA | 3.60e-01 | NA | 0.0e+00 | ABCC8,ACSL1,ACVR1B,ADH1C,ADI1,ADIPOQ,AMD1,AP1S2,ATP1A1,ATP1B1,ATP2A2,ATP2B4,ATP6V1E1,BDNF,BTG1,CACNA1B,CACNB2,Calm1 (includes others),CASP8,CCND2,CDC34,CHPF,CKAP4,COL6A3,CXXC4,DAAM1,DAPK3,DNAJA1,DOLK,EEF1A1,EEF1A2,EGF,EGLN1,EIF5B,ENO2,ERO1B,FN1,FZD1,GM2A,GNAS,HAP1,HERC2,HERPUD1,Hnrnpa3,HNRNPC,IDH1,IL10RB,LCMT2,LPCAT1,MAN2A1,MAOB,MCOLN1,MMP2,MSI2,MTHFD2,MYH10,NDUFA1,NFAT5,NKX6-1,NTRK2,NUDT5,NUP93,PARK7,PC,PDE1C,PDIA4,PECR,PEX6,PIK3R3,PLCB1,PRDX1,PTGS2,RDX,RHOBTB1,RPL18,RPL35,RPL37A,RPL6,RPP38,RPS18,RPS2,SEC24A,SLC2A1,SMAD7,SMPD3,SRSF3,STT3A,TFDP2,TGFB1,TOB2,TYMS,UBE2M,UBQLN2,UGGT2,VCP,VEGFC,WNT4,XPO1,YWHAQ | 1440 (22) |
| nitric oxide | NA | chemical - endogenous mammalian | NA | 3.50e-01 | NA | 2.0e-02 | AHR,ATF3,BCL2L1,Ccl7,CCND1,CD44,CDKN1A,CTSH,CXCL10,CXCL12,DPYSL3,DUSP1,DUSP6,EDN1,EGR1,FOXP3,GADD45A,GCLC,HSP90AA1,IER3,IL17A,MGST1,MKI67,MMP2,Mt1,NCAM1,NFE2L2,NID1,PDIA4,PRDX5,PRKDC,PTGS2,RHBDF2,RXRG,SELE,SGK1,SPP1,THBS1 | NA |
| ARHGAP31 | -2.50e-01 | other | NA | 3.50e-01 | NA | 0.0e+00 | CDH1,CDH2,COL5A1,FN1,GADD45B,GDF11,ID2,ITGA5,MMP28,OCLN,SNAI1,SPARC,TWIST2,ZEB2 | 808 (13) |
| LAMA2 | -7.10e-01 | other | NA | 3.50e-01 | NA | 1.0e-02 | ACTA2,CSK,LAMA2,LAMA4,OCLN,PLVAP | NA |
| fluphenazine | NA | chemical drug | NA | 3.50e-01 | bias | 2.0e-02 | NR4A1,NR4A2,NR4A3,NTS | NA |
| alkali-extractable mycelial polysaccharide | NA | chemical reagent | NA | 3.40e-01 | NA | 1.0e-02 | CDH1,CDH2,SNAI1,SREBF1,VIM | NA |
| CHD4 | 7.00e-02 | enzyme | NA | 3.40e-01 | NA | 1.0e-02 | AATK,BCL11A,CDKN1A,CPNE6,CPNE7,DAPK1,DUOX2,EZH2,GNB3,HMCN2,ID2,ID4,JAK3,LOX,NCEH1,RRAD,SCN3B,SFRP4,SMOC1,SOCS3,TNNC2 | 459 (5) |
| pimozide | NA | chemical drug | NA | 3.40e-01 | NA | 3.0e-02 | BCL2L1,CCND1,CCND2,CISH,CSF1R,IRF8,PRKAA1 | NA |
| SH3PXD2A-AS1 | NA | other | NA | 3.30e-01 | NA | 1.0e-02 | BDKRB2,CX3CL1,HIF1A,IER3,MET,PROM1,SERPINE1,TGFA,TRPM2 | NA |
| oleic acid | NA | chemical - endogenous mammalian | NA | 3.30e-01 | NA | 0.0e+00 | ABCA1,ACADL,ACSL1,ALOX5,ANKRD23,ARG1,ATF3,Ccl2,CD36,CERS6,CX3CL1,CYBB,CYP4F2,DUSP1,EDN1,EGR1,FABP1,GADD45A,GADD45B,GAPDH,GCLC,GPAM,HIF1A,ICAM1,IGF1,LPL,MAP1LC3A,MAP1LC3B,Mt1,NCF1,NFKBIA,NR4A1,OLR1,PDK4,PLIN1,PLIN3,PLIN4,PNPLA2,PNPLA3,PPARG,PRKAA1,PTGS2,RXRA,SELE,SERPINE1,SOAT1,SPHK1,SREBF1,TLR2,TLR4,UCP3,VCAM1 | 1256 (23) |
| K+ | NA | chemical - endogenous mammalian | NA | 3.20e-01 | NA | 3.0e-02 | ATF3,BCL2L11,BDNF,CASP3,EGR1,GAPDH,KCNC1,NR4A1,NR4A2,PENK,RTN3,SCNN1G,SLC12A4,STAR | NA |
| BMI1 | NA | transcription regulator | NA | 3.20e-01 | NA | 2.0e-02 | BTG2,CASP8,CDC14A,CDH1,CDKN1A,DLC1,HOXC5,ID4,LOX,MET,NID1,PARP9,RASSF5,RASSF9,USF2,VEGFC,VIM,WNT10B | NA |
| NOS3 | -2.00e-01 | enzyme | NA | 3.20e-01 | NA | 0.0e+00 | ACTA1,ADGRE1,ADIPOQ,ATF3,Ccl2,CD86,COL3A1,CXCL12,F3,FN1,ICAM1,MMP14,MMP2,NPR1,PDE5A,PTGS2,SLC2A1,SNAI1,TGFB1,TLR4,VCAM1 | 1234 (17) |
| Hsp27 | NA | group | NA | 3.20e-01 | NA | 0.0e+00 | BMP15,CASP3,CASP8,CCND1,CD86,CDKN1A,CSF1,CSF1R,EIF4EBP1,FBXO32,GCH1,NOX4,PLA2G2A,PTGS2,TGFB1,TMPRSS2,TRIM63 | 1249 (19) |
| RXRA | 8.90e-01 | ligand-dependent nuclear receptor | NA | 3.10e-01 | NA | 0.0e+00 | ABCA1,ABCA4,ABCC3,ABCG1,ACSL1,ACSL3,ACSL5,ADH1C,ALDH1A1,AQP7,ASNS,C3,CALB1,CAMK1D,Ccl6,CCNA2,CCND1,CD109,CD36,CD86,CDK6,CDKN1A,CDO1,CEBPD,COL1A1,COLEC12,CRYAB,CTSH,CTSS,CXCL10,CXCR5,DLK1,ECM1,ECT2,EHD3,ENG,EPHX1,FABP1,FADS2,FLRT3,FSTL1,FTL,GADD45G,GCLC,GPD1,GPR183,HAS2,HCK,HIF1A,HOXD10,HSD17B4,IER3,IGF1,IGFBP6,IL7,ITGB3,KLF9,LPL,LSR,MAOB,MAP1B,MMP2,MTERF3,MYCN,MYOG,NDUFC2,NEDD9,NR0B2,NR5A2,NRK,OLR1,OSMR,PC,PDGFB,PES1,PLA2G2A,PLCL1,PLD1,PLIN1,PLTP,PMP22,PNMT,PPARD,PPARG,RARA,RARG,RBPJL,RET,RGN,RXRA,RXRG,S100A4,S100A6,SDC1,SELP,SFTPB,SLAMF1,SLC16A2,SLC27A1,Slco1a4,SPP1,SREBF1,STAR,STRA6,TGFB1,THBD,UCP3,VCAN,WEE1 | 1541 (22) |
| RBPJ | -5.20e-01 | transcription regulator | NA | 3.10e-01 | NA | 0.0e+00 | ABCG1,AXIN2,BMP3,CD44,CD74,CDKN1A,CIITA,CORO1A,CRP,CSF1,CXCL12,CYTH4,DHCR7,DLL1,DUSP1,ECT2,EGF,EPHA4,ETHE1,ETS1,EZH2,FADS2,FGF1,FGF10,FGF2,FGF9,GDF10,GNAI1,GPX8,HAS2,HGF,IGF1,IKBKB,IL17A,IL17RA,IL1RN,INHA,INHBA,INHBB,IRF8,ITGAL,JAG1,KDR,KITLG,MAPK14,MDK,MIB2,mir-143,MSTN,MVD,MYOG,NFATC3,NR4A1,NRP2,P2RY6,PCED1B,PDGFB,PIK3CG,PRDM1,PTGIR,SDC1,SLAMF9,SLC25A35,SLC2A1,SNAI1,SNAI2,STAR,TNC,TWIST1,VEGFC,VEGFD,WNT5A | 1383 (18) |
| SERPINF1 | -1.40e+00 | other | NA | 3.10e-01 | NA | 0.0e+00 | ACTA2,ADIPOQ,AXIN2,BCL2A1,BCL2L1,BDNF,CCND1,CD34,CRYAB,CSPG4,CYBA,CYBB,ENO2,G0S2,LOXL1,LOXL2,NFKBIA,NFKBIB,OCLN,PDGFRA,PPARG,SELP,SERPINF1,SOX10,TGFB1,THBS1,TNFRSF11B,VIM | 1437 (18) |
| MSTN | 1.47e+00 | growth factor | NA | 3.00e-01 | NA | 0.0e+00 | ACTA2,AKIRIN1,CDK2,CDKN1A,CKM,CTSK,FBXO32,FN1,GDF11,HIF1A,IGF1,IGFBP5,INHBA,INHBB,KLF10,MAP1LC3B,MYF5,MYH7,MYO5A,MYOD1,MYOG,PPARG,RUNX2,SERPINH1,SLC2A1,SMAD9,SPP1,STAR,TGFB1,TNC,TRIM63,VIM | 1534 (21) |
| CD300LF | -1.90e+00 | other | NA | 3.00e-01 | NA | 0.0e+00 | ACAD8,ACADL,CALCR,GPD1,GPD2,GPI,HK1,IDH1,IL1RN,SLC27A1,SLC2A1 | 645 (7) |
| Dst | 2.40e-01 | other | NA | 3.00e-01 | NA | 3.0e-02 | ACTA2,ANKRD1,CD44,CENPF,DOK5,MAP2,MYBPC2,PDE1C,RP1,RTN4R,SEC14L5,UBXN10 | NA |
| p70 S6k | NA | group | NA | 2.90e-01 | NA | 0.0e+00 | BCL2L11,CCND1,CDH1,CDH2,EEF1A1,GAP43,NOX4,PLD2,RUNX2,SNAI1,SREBF1,VIM | 1449 (23) |
| CHD8 | 2.00e-01 | enzyme | NA | 2.90e-01 | NA | 1.0e-02 | ARHGAP45,Calm1 (includes others),CCNE2,CDC42EP3,CENPK,CSK,DEPDC1B,DYNLL1,ESYT1,IRF3,KIF18A,MAP2,MAPK3,PIK3R1,PRC1,RHOF,TMPRSS2,VANGL1 | NA |
| SSRP1 | 9.00e-02 | transcription regulator | NA | 2.80e-01 | bias | 0.0e+00 | ACTA1,CDKN1A,CPNE6,DUSP5,EGR1,ID2,LOXL2,LYPLA1,MSN,MYH6,POLR3G,TAGLN,TNNI2 | 519 (7) |
| SLC6A4 | -8.40e-01 | transporter | NA | 2.80e-01 | NA | 0.0e+00 | ALDH1A1,CCL21,COL1A1,CRB1,DYNLT1,GNAI1,GPNMB,H2AC18/H2AC19,HTR1B,HTR2A,HTR7,REC8,SLC1A5,TNFRSF8,TPH1 | NA |
| Kallikrein | NA | group | NA | 2.80e-01 | NA | 2.0e-02 | BDKRB2,Ccl2,ICAM1,TGFB1,VCAM1 | NA |
| EGR4 | -3.00e-02 | transcription regulator | NA | 2.80e-01 | NA | 3.0e-02 | CREM,EGR1,EGR2,MYBL1 | NA |
| GPRC5A | -6.90e-01 | G-protein coupled receptor | NA | 2.80e-01 | NA | 5.0e-02 | Ccl2,CD44,PTGES,SLC1A1 | NA |
| ADAM9 | 5.00e-02 | peptidase | NA | 2.80e-01 | NA | 0.0e+00 | CHAC1,DDIT4,ITGA3,SLC1A4,TGFB1,TIMP1 | 1367 (15) |
| AC261066 | NA | chemical reagent | NA | 2.80e-01 | bias | 4.0e-02 | Ccl2,COL1A1,COL3A1,KHK,LGALS1 | NA |
| MOGAT1 | NA | enzyme | NA | 2.80e-01 | NA | 4.0e-02 | ACADL,BDH1,Ccl2,CXCL10,TIMP1 | NA |
| LDHA | NA | enzyme | NA | 2.60e-01 | NA | 0.0e+00 | CCND1,COL6A3,DDIT4,EIF4EBP1,FLT3LG,FN1,GNG11,ITGA1,ITGA10,ITGA3,LAMA3,LAMA4,LAMC2,PDGFB,PIK3R3,RELN,SLC1A5,THBS2,THBS4,VEGFC,VWF | 1013 (13) |
| thalidomide | NA | chemical drug | NA | 2.60e-01 | NA | 0.0e+00 | ANGPT2,BCL2L1,BIRC3,CAV1,COL1A1,FGF2,GADD45B,ICAM1,KDR,NRP1,NRP2,PDGFB,SERPINE1,TGFB1 | 1489 (16) |
| DLK1 | -9.10e-01 | other | NA | 2.60e-01 | NA | 2.0e-02 | DLK1,FOXO1,GLI1,HEY2,IL7,IRF1,MSTN,PPARG,REL,SNAI1,SNAI2,SYP,TSHR | NA |
| CYGB | -8.00e-01 | transporter | NA | 2.60e-01 | NA | 0.0e+00 | ADPRHL1,CACNA1E,CASP1,CD74,CDH1,CXCR4,DMTN,FBLN1,LONRF1,MDK,MGAT3,NLRP3,PLA1A,SYK,WIPF3 | NA |
| WNT16 | -2.19e+00 | other | NA | 2.50e-01 | bias | 2.0e-02 | ACADL,ACADS,AXIN2,CDKN1A | NA |
| ICI 118,551 | NA | chemical reagent | NA | 2.50e-01 | NA | 3.0e-02 | ADRB2,GNAI3,PTGS2,SELP | NA |
| mir-373 | NA | microRNA | NA | 2.50e-01 | NA | 3.0e-02 | CD44,CDH1,CDK2,LAMP2,RECK,SERPINE1 | NA |
| ASXL2 | -3.80e-01 | other | NA | 2.40e-01 | bias | 0.0e+00 | BAP1,Cox8b,ENO2,FAM162A,G0S2,GPCPD1,GPD2,HYAL1,KLF15,LPL,PELI2,PGK1,PLIN1,PPARG,PPARGC1B,RAB12,SERPINE1 | 618 (7) |
| ASXL1 | -1.50e-01 | transcription regulator | NA | 2.40e-01 | NA | 0.0e+00 | BAP1,Cox8b,ENO2,FAM162A,G0S2,GPCPD1,GPD2,HOXA5,HYAL1,KLF15,LPL,PELI2,PGK1,PLIN1,POLR2K,PPARG,PPARGC1B,RAB12,RPL22,SERPINE1 | 621 (7) |
| MAML1 | -7.00e-02 | transcription regulator | NA | 2.40e-01 | NA | 2.0e-02 | CCND1,CDH1,CKM,DTX1,EGR1,HEY2,RND3 | NA |
| miR-423-5p inhibitor | NA | chemical reagent | NA | 2.40e-01 | NA | 0.0e+00 | ACTA1,CDH1,CDH2,VIM | 1126 (11) |
| HSPG2 | NA | enzyme | NA | 2.30e-01 | NA | 1.0e-02 | ACTA2,ATG2A,COL2A1,CTSS,CXCR4,DRAM1,GADD45A,HSP90AA1,IGF1,MAP1LC3A,RAB9B,RPS6KB1 | NA |
| SUZ12 | -1.20e-01 | enzyme | NA | 2.30e-01 | NA | 4.0e-02 | ACKR3,ANXA8/ANXA8L1,ATP2A2,CALU,CBX6,CDH1,CNR1,DAB2IP,FBXO32,GATA4,HOXB5,HOXD10,IRAK3,JAM2,JUND,KCNA1,KLF4,LAMC2,LITAF,MAP7D1,MMP2,NKD1,PAX3,PPP2R2B,SNAI1,TBX3,TGFB1,TNFAIP2,TNFRSF11B,TNFRSF1B,UHMK1 | NA |
| kanamycin A | NA | chemical drug | NA | 2.20e-01 | NA | 0.0e+00 | ABCC3,ABI1,AGMO,AK1,ALCAM,APOD,BACH1,BMP1,BMP4,CCND1,CD9,CITED2,CRYL1,CSF1,DNAJB4,EXTL3,GPM6A,IGFBP5,IL10RA,KHDRBS3,LAMP2,LGALS1,MCOLN1,MMP2,NUAK1,PTPRZ1,RHOA,RTN4RL1,SLC7A8,SLCO4A1,SORT1,SPP1,ST3GAL6,SYNJ1,TMC7 | 599 (7) |
| CLIC4 | -1.06e+00 | ion channel | NA | 2.20e-01 | NA | 0.0e+00 | ABCA4,BEST1,C3,CFH,CFI,COL8A1,CX3CR1,DCN,DDR1,ELOVL4,FBLN5,HIC1,HMCN1,IER3,LPL,LSS,MMP2,PLTP,RDH5,SLC16A3,TLR4,VIM | 968 (9) |
| CRTC1 | 6.90e-01 | transcription regulator | NA | 2.10e-01 | NA | 0.0e+00 | BDNF,IDH3A,NEDD9,NR4A1,NR4A2,PDE10A,PDE4D,PER1,PTGS2,TIMP1 | 839 (10) |
| nickel | NA | chemical toxicant | NA | 2.10e-01 | NA | 0.0e+00 | CD86,FGF2,GAPDH,HIF1A,ICAM1,IL1RN,Mt1,PLAT,SERPINE1,UGCG | 849 (18) |
| PLIN5 | 4.50e-01 | other | NA | 2.10e-01 | NA | 0.0e+00 | ABHD5,ACADL,ACTA2,COL1A1,FABP1,GCLC,NFE2L2,PDK4,PNPLA2,PNPLA3,PPARG,PPARGC1B,SREBF1,UCP3 | 1189 (17) |
| CXCR3 | -5.50e-01 | G-protein coupled receptor | NA | 2.10e-01 | NA | 2.0e-02 | ATP1B2,BCL2L1,Ccl2,COL1A1,CXCL10,FN1,GFAP,MAP1LC3B,SLC26A3,TNC | NA |
| CDKN2B | 2.30e-01 | transcription regulator | NA | 2.10e-01 | NA | 4.0e-02 | ASNS,BCAT1,BCAT2,CD86,GLUL,GPT2,PHGDH,SERPINE1,SHMT1 | NA |
| Hsp70 | NA | group | NA | 2.10e-01 | NA | 0.0e+00 | BCL2L1,Ccl2,CD83,CD86,CDK5R1,FBXO32,GAPDH,GZMB,HIF1A,HRAS,ICAM1,IL17A,MLKL,NFKBIA,NOD2,SELE,SNCA,TRIM63,VCAM1 | 776 (15) |
| RELN | -2.52e+00 | peptidase | NA | 2.10e-01 | NA | 2.0e-02 | ABCA1,BDNF,DAB1,GAD1,NTRK2 | NA |
| salirasib | NA | chemical drug | NA | 2.10e-01 | NA | 0.0e+00 | AK4,ATF3,BHLHE40,CA9,CITED2,COL5A1,COL5A2,ENO2,HIF1A,HRAS,LGALS1,OCLN,PDGFRA,PFKFB3,PFKFB4,PGK1,PGM1,PKM,PLAT,PLOD2,SERPINE1,SLC2A1,TGFA,VEGFC | 1555 (21) |
| pravastatin | NA | chemical drug | NA | 2.10e-01 | NA | 4.0e-02 | ABCA1,ADIPOQ,CAV1,COTL1,CRP,CYP27A1,ENC1,FOXP3,HBA1/HBA2,ICAM1,POLG,SDC4,SLC16A7,TGFB1,TLR4,VWF | NA |
| uranyl nitrate | NA | chemical toxicant | NA | 2.00e-01 | NA | 0.0e+00 | ACADS,ADH1C,Calm1 (includes others),CD74,CSRP1,CYP4B1,FAU,FTL,GPI,GPX3,HSD17B4,ID2,IGFBP7,LAMP2,NDUFA1,NDUFB9,PEBP1,PIM3,PRDX1,RIDA,RPL23,RPS16,RPS24,SELENOP,SPP1,STARD10,TAGLN,TAGLN2,TXNL4A,UBC | NA |
| voltage-gated calcium channel | NA | complex | NA | 2.00e-01 | NA | 2.0e-02 | ACTA1,CCND2,CD34,NR4A2,PTPRC | NA |
| ZMYND8 | 3.00e-01 | transcription regulator | NA | 2.00e-01 | bias | 2.0e-02 | BMP4,CDKN1A,DAB2IP,FOXP3,RUNX2 | NA |
| TNFRSF12A | 2.30e-01 | transmembrane receptor | NA | 2.00e-01 | NA | 0.0e+00 | ACTA1,BCL2L1,Ccl2,CKM,CXCL10,MYBPC2,MYOD1,MYOG,TRIM63 | 1473 (24) |
| batimastat | NA | chemical - protease inhibitor | NA | 2.00e-01 | NA | 0.0e+00 | AIF1,CASP1,EGF,FGF2,HGF,MET,MMP14,MMP2,SDC4,SLC2A1 | 1445 (19) |
| SOCS2 | -1.20e-01 | other | NA | 1.90e-01 | NA | 0.0e+00 | CD83,CD86,CXCL10,IGF1,MYH7,MYOD1,MYOG,PIM3,PPARG,STAT6 | 1096 (16) |
| FASLG | -2.90e-01 | cytokine | NA | 1.90e-01 | NA | 3.0e-02 | CASP3,CD44,CDH1,CXCL10,EGR1,EGR2,FADD,IL17A,PROM1,RUNX2,STAT6,TGFB1,THY1,TNFRSF11B | NA |
| metribolone | NA | chemical reagent | NA | 1.90e-01 | NA | 0.0e+00 | ABCC4,ACSL3,ACTN2,ADAMTS1,ADH1C,ADRM1,AKAP12,Akr1b7,ALDH1A3,ALDH9A1,ALDOA,ARG1,ARID5B,ARL6IP1,ATP1B1,ATP6V0B,ATP6V1E1,ATP6V1F,B2M,B3GALT6,B3GAT3,B4GALT1,BCL2L1,BPGM,BUB1,C14orf28,CAPN5,CAV2,CCNA2,CCND1,CDC14B,CDK5R1,CDKN1A,CHPF,COX4I1,COX6B1,CPEB3,CRYAB,CXCR4,D2HGDH,ECH1,EDEM1,EDEM3,EGR1,ELL2,ELOVL5,ERRFI1,ESRRG,ETV1,EZR,FADS1,FHL2,FKBP5,FLVCR2,FOXO1,FZD5,GADD45G,GAPDH,GPI,GRHPR,HK1,Hnrnpa3,HOMER1,HOMER2,HSD17B4,HUS1,IDH3A,IGF1,IGFBP5,INPP4B,IQGAP2,IRS2,ITGA6,ITGB4,KAT5,KMT5A,KRT19,Ldha/RGD1562690,MAF,MAP7,MDH1,MMP2,MRPL34,MRPS30,MYL12B,NDUFA1,NDUFA7,NDUFAB1,NDUFB3,NDUFC1,NDUFC2,NDUFS7,NDUFV2,NEDD4L,NNMT,NTHL1,PDE4D,PGK1,PKM,PMEPA1,PPIA,PPIB,PRKCD,PROS1,RAB27A,REEP6,RGMA,RIMS2,SAP30,SEC24D,SELENOP,SLC16A3,SLC1A4,SLC1A5,SLC37A4,SLC38A2,SOCS1,SORD,SPCS3,SPDEF,SREBF1,STEAP2,SYTL2,TACC2,TGM4,THBS1,THTPA,TIMM9,TM4SF1,TMPRSS2,TNFAIP8,TRIM36,TWIST1,UAP1,UGDH,UQCR10,VCAN,WEE1 | 1634 (20) |
| MYC | 1.00e-02 | transcription regulator | NA | 1.80e-01 | NA | 0.0e+00 | ABCA1,ABCA7,ABCB9,ABCC3,ABCC4,ABCG1,ABCG4,ACTA1,ACTA2,ACTN4,ACVR1,ADAMTS1,AHR,AKAP12,ALCAM,ALDH18A1,ALDOA,ALOX15,ALOX5,AMD1,ANGPT2,ANXA5,APCDD1,ARG1,ARL6IP1,ASNS,ATAD3A,ATP6V0B,AXL,BCAT1,BCL2A1,BCL2L1,BCL2L11,BCL6,BCR,BDNF,Bex3,BIN1,BOP1,BUB1,BUB1B,Cald1,Calm1 (includes others),CASP1,CASP3,CASP8,CAV1,CBFA2T3,Ccl6,CCNA2,CCND1,CCND2,CCNE2,CD44,CD47,CD48,CD86,CD9,CDC25B,CDC34,CDC42EP3,CDH1,CDH2,CDK2,CDK6,CDKN1A,CEBPD,CHKA,CHP1,CHST15,CKAP4,CLDN1,Clec2d (includes others),CLEC3B,CLIC4,CNP,COBLL1,COL14A1,COL1A1,COL2A1,COL3A1,COL5A1,COL5A2,COL6A3,COL8A1,COX6B1,Crip2,CRYAB,CSDE1,CSF1R,CSPG4,CSRP2,CSTB,CTNNAL1,CXCL10,CXCR4,DBN1,DCTPP1,DDIT4,DDX27,DEK,DKC1,Dstn/Dstnl1,DUSP1,DUSP5,DUSP6,E2F2,EBF1,ECM1,ECSIT,EDN1,EGLN1,EGR1,EGR2,EIF3G,EIF4EBP1,ELAVL1,EMP1,EMX2,ERAP1,EXOSC7,EZH2,EZR,F2R,F3,FABP1,FADS2,FAP,FARP1,FBLN5,FBN1,FBN2,FBXO32,FCGR1A,FCGR2B,FCGR3A/FCGR3B,FCGRT,FGF10,FGFR1,FKBP5,FLNA,FMOD,FN1,FOXP3,FRZB,FSTL1,G6PD,GADD45A,GADD45B,GADD45G,GAMT,GAPDH,GATA4,GBP2,GBP4,GCLC,GFER,GLI2,GLUL,GM2A,GPC3,GPI,GPT2,GSR,H6PD,HAS2,HIF1A,HLA-A,Hmgn2 (includes others),HNRNPU,HOXA5,HRAS,HSP90AA1,HSPE1,ICAM1,ID2,IDH1,IER3,IER5,IFI16,IFI44,IFI44L,IFIH1,IFIT1,INHBA,IQGAP2,IRF4,IRF6,IRS1,ISG15,ITGA1,ITGA3,ITGA6,ITGAL,ITGBL1,JAG1,KDR,KLF10,KLF4,KLF6,LAMP2,Ldha/RGD1562690,LDHB,LGALS1,LGR5,LIMA1,LIMS1,LOC100359583/Ptma,LOX,LRRN1,LSM4,LUM,LYN,MAG,MAN2A1,MAP4K1,MAPK3,MAT2A,MAX,MCM7,ME2,MITF,MKI67,MRC1,MSN,MSR1,Mt1,MTERF3,MX1,MYBPH,MYCN,MYCT1,MYH7,NCAM1,NDN,NFAT5,NFATC3,NFE2L2,NFKBIA,NMI,NRP1,NUCB1,NUDC,OASL,Oasl2,OAZ1,OLR1,PAM,PCDH18,PDGFRA,PDLIM7,PFKFB1,PFKFB3,PGK1,PHF20,PITX2,PKM,PLA1A,PLK1,PLP1,PLS3,PMEPA1,PMP22,POLR1B,PPARD,PPARG,PPIA,PRDM1,PRDX4,PROM1,PTGS2,PTN,PTPRC,RAB40B,RANBP1,RARA,RARG,RARRES1,RBBP4,RHOA,RHPN1,RIN3,ROCK1,RPL14,RPL17,RPL18,RPL22,RPL23,RPL28,RPL35,RPL37A,Rpl38 (includes others),RPL6,RPL7L1,RPS10,RPS11,RPS15,RPS15A,RPS16,RPS18,RPS2,RPS24,RPS3,RSAD2,S100A10,S100A6,SCAMP5,Scd2,SEC61A2,SEMA4A,SERPINE1,SERPINH1,SFRP1,SFXN1,SGK1,SHMT1,SIRT2,SKP2,SLC16A1,SLC16A3,SLC16A7,SLC1A5,SLC2A1,SLC38A1,SMOX,SNAI1,Snrpc,SNRPN,SOX6,SPARC,SPN,SPP1,SREBF1,SRSF1,ST3GAL1,STAT1,STAT6,STMN1,SUMO2,SUMO3,TAF1C,TAGLN2,Tcf7,TES,TGFB1,THBS1,THBS2,THY1,TIMP1,TKT,TLE1,TLR7,TMSB10/TMSB4X,TNC,TNFRSF10A,TNFRSF19,TNFRSF8,Tpm1,TWIST1,TWIST2,TYMS,USP18,VCAM1,VEGFC,VIM,WDR4,WEE1,WLS,WNT5A,XPO1,ZFP36,ZFP36L1,ZNF48 | 1871 (22) |
| sulindac | NA | chemical drug | NA | 1.80e-01 | NA | 1.0e-02 | ALOX15,CCNA2,CCND1,CDK2,CDKN1A,CYP1B1,DCN,E2F2,E2F5,ERBB3,G0S2,GCLC,LAD1,MYCN,PLA2G4A,PTGS2,RBBP4,RBL1,WEE1 | 1333 (17) |
| ZC3H12A | 4.90e-01 | enzyme | NA | 1.80e-01 | NA | 0.0e+00 | ABCC4,ADAM19,ADIPOQ,ANTXR2,APBB1IP,ARAP2,BATF,BCL3,C15orf48,CABLES1,CACNA1I,Ccl2,CD244,CEACAM1,CEBPD,CSRP2,CTSS,CXXC4,DUSP1,DUSP5,EGLN2,ELOVL5,ENG,FAM107B,FAM111A,FCGR2B,GBP4,GBP5,GPR183,HPSE,ICAM1,IL10RA,IL2RG,IL33,IRF5,IRF8,ITGB3,LPL,LRRC8D,MAF,MAPK3,NCF1,NEIL1,NUP210,P2RY10,PDIA4,PIK3CG,PKIB,PLEK,POU2F2,PPARG,PPP1R18,RAC2,RARA,REL,RGS2,RHOF,RRAD,SAMSN1,SFRP4,SIGLEC10,SLIT3,SMAD7,TES,TGFB1,TMEM123,TNFAIP2,TNFAIP8,TNFRSF1B,TNFRSF4,TRIB1,VPS37B,ZC3H12D,ZFP36,ZFP36L1,ZNF608 | 1108 (14) |
| NCOA4 | -5.10e-01 | transcription regulator | NA | 1.80e-01 | NA | 0.0e+00 | CDH1,CLDN3,FTL,FYN,GAD1,GATA4,GNAL,JAG1,MME,PLTP,ST14,ST3GAL6 | 1151 (7) |
| Tetanospasmin | NA | chemical - endogenous non-mammalian | NA | 1.80e-01 | NA | 2.0e-02 | CAMK2A,GAD1,GRIA2,KCNA1,KCNA2 | NA |
| fulvestrant | NA | chemical drug | NA | 1.80e-01 | NA | 0.0e+00 | ADRB2,ASNS,AXL,BARD1,BMP4,C3,CA12,CAV1,CAV2,CCDC80,Ccl2,CCNA2,CCND1,CD74,CDC25B,CDH1,CDKN1A,CDKN2C,CEBPD,CENPF,CLK1,CSF1,CXCL10,CXCL12,DDIT4,DYNLL1,EGR1,EGR3,ERBB3,F2R,FEN1,FGF9,G6PD,GADD45A,GJB2,HRAS,ICAM1,ID2,IER3,IGF1,IGFBP5,INHBB,IRF1,IRS1,ITGB3,KIF11,KLF10,LEPR,LPL,MAPK14,MB,MCM7,MYH6,NOS1,NRP1,PLK2,POLA2,PPARG,PTGER3,PTGES,PTGS2,RAB2A,RBL1,RFC2,RFC5,RNF126,SELENOP,SELP,SEMA7A,SERPINB9,SIAH2,SKP2,SLC9A3,SNAI2,STAR,STMN1,TGFA,TGFB1,TNFRSF11B,TTC9,USP19,VCAM1,WEE1,WNT4 | 1769 (24) |
| RELB | 2.00e-01 | transcription regulator | NA | 1.80e-01 | NA | 1.0e-02 | ANXA5,B2M,BCL2L1,BIRC3,CCND1,CCR3,CDKN1A,CHI3L1,CIITA,CXCL12,CXCL13,IRF4,MARCKSL1,MAT2A,NFKBIA,NFKBIB,PLPP3,PPARGC1B,PRDM1,PTGS2,TGFA,TNFAIP2 | 1102 (18) |
| CD274 | -3.60e-01 | enzyme | NA | 1.70e-01 | NA | 4.0e-02 | ACTA2,ATG2A,BCL2L1,CD226,CD86,CHKA,COL1A1,FGF1,FGF2,FOXP3,GZMB,ICAM1,IFIT1,IGF1,IL17A,MX1,PTGS2,TGFB1,THBS2,WNT9A | NA |
| mibolerone | NA | chemical drug | NA | 1.70e-01 | NA | 0.0e+00 | ACSL1,AHR,ALCAM,ALDH18A1,AMD1,CALU,CCDC80,CCND1,CD74,CEACAM1,CLEC11A,CLTB,COL1A1,COL6A3,DAD1,F3,FHL1,FKBP11,FKBP5,GADD45G,GPC3,GPNMB,HLA-DQA1,IDH3G,IGF1,KLF10,LPL,LRG1,LSS,MAL,MAN2A1,MAT2A,MME,NANS,PGK1,PPIA,PPIB,PRELP,Scd2,SERP1,STMN1,TGFBI,TMED3,TMPRSS2,TOP2A,TUBA1A,UCP3,UFM1,USP18 | 1164 (7) |
| VCAN | -1.59e+00 | other | NA | 1.70e-01 | NA | 0.0e+00 | ACTA1,ADAMTS9,ANXA8/ANXA8L1,BDNF,C1R,C3,Calm1 (includes others),CASP1,CASP3,CASQ2,CBX6,Ccl2,CD34,CDKN1A,CXCL12,CYBA,DCN,ELN,F3,FBLN5,FN1,FNDC1,HAS2,HAS3,HYAL1,ICAM1,IFI44,IFI44L,IFIT1,IGFBP4,IL1RN,INHBB,IRF8,ITGA3,ITGA5,LBP,LGALS9B,LOXL4,MAP1B,METRNL,MSLN,MX1,MYH10,NFKBIA,OAS3,OGN,OLFML2B,PAM,PARP14,PCSK1N,PCSK5,PENK,PLA2G2A,PRDX5,PRELP,PTGIS,RGS2,RNASE4,ROCK1,RXRA,SERPING1,SMOC1,SMPDL3B,SORT1,ST6GAL1,STAT1,TGFA,TGFB1,THBD,TIMP1,Tpm1,VCAM1,VCAN,WNT4 | 1278 (15) |
| ENG | -8.10e-01 | transmembrane receptor | NA | 1.70e-01 | NA | 0.0e+00 | ACTA2,BARD1,CXCR4,ELN,FN1,ITGA1,ITGA5,ITGA6,ITGB3,KDR,MMP19,NTHL1,PDGFB,PTPRJ,RAC2,SERPINE1,SMAD6,SMAD7,TGFB1,THBS1,TWIST1 | 1450 (20) |
| Lh | NA | complex | NA | 1.70e-01 | NA | 0.0e+00 | ACP5,ACTA1,ACTA2,ACTG2,ADAMTS1,ADCY7,AKAP12,ARHGEF5,ATP2A2,ATP9A,AXL,BCL6,BDNF,CCND2,CDC42EP4,CDK14,COL18A1,CREB1,CXCR4,DAB2,DAPK1,DHCR7,DUSP1,EEF1A1,EEF1E1,EGR1,EZR,FKBP5,GADD45B,GADD45G,GNAS,GRK5,HAS2,INHA,INHBB,ITGA3,MAP1LC3B,MAPK14,MMP19,MMP2,MSMO1,NR4A1,NR5A1,PAWR,PDE4D,PER1,PGK1,PGRMC1,PIM3,PLAT,PLCL1,PLIN3,POP5,PRKD1,PRKX,PSIP1,PTGS2,PTPRF,PTX3,RAB27A,RAB2A,RAB31,RGS2,RGS4,RGS7,RPL17,RPL23,RPL28,RPL35,RPL6,RPS10,RPS11,RPS15,RPS15A,RPS16,RPS18,RPS2,RPS24,RUNX1,RUNX2,SFRP4,SGK1,SLC16A3,SLC1A4,SLC38A1,SLC7A1,STAR,STAT1,TBX3,TFPI2,THBS1,THBS2,TNFAIP6,TNFRSF11B,TRIB1,TUBA1A,TYRO3,VEGFC,ZBTB16 | 1843 (20) |
| SOX8 | -1.95e+00 | transcription regulator | NA | 1.60e-01 | NA | 1.0e-02 | DLK1,EZH2,MYRF,PLP1,RUNX2,SPARC | NA |
| EPCAM | 3.10e-01 | other | NA | 1.60e-01 | NA | 3.0e-02 | ADGRE1,ATF3,Ccl2,CCND1,CCNE2,CDH1,CDKN1A,EGR1,FHL2,IRF1,MMP19,RUNX2,SNAI2 | NA |
| MLX | 3.10e-01 | transcription regulator | NA | 1.60e-01 | NA | 1.0e-02 | ATF3,BCL2L11,Casp12,Ccl2,Ccl7,DIO1,IL16,IL1RN,MAX,MLXIP,MYCN,PROM1,THBS2,TIMP1,WNT4 | NA |
| ADRB | NA | group | NA | 1.60e-01 | NA | 0.0e+00 | AACS,ADCY4,ANKRD1,ANXA5,ARG1,ARHGEF3,ATF3,AXL,BDNF,BHLHE40,BRCA2,CASP3,Ccl2,CCNA2,CCND1,CDK6,CDKN1A,CREM,CRYAB,CXCL10,DDIT4,ENDOD1,GADD45A,GATA4,HSD3B7,ICAM1,IDH1,KLF4,KLHL6,LBH,LPIN1,LSS,LTBP1,MSMO1,MVD,NFKBIA,NOTCH2,NR4A1,NR4A2,NR4A3,NUDT18,OASL,PDGFB,PTGS2,RSAD2,SLC6A9,SLCO4A1,SMAD6,TEK,TRIM54,WEE1 | 1298 (19) |
| SYK | -1.39e+00 | kinase | NA | 1.50e-01 | NA | 0.0e+00 | AKAP12,ARID5A,BCL2L11,BIRC3,CCND1,CD44,CITED2,CREB1,CREM,CXCL10,CXCR4,DOCK10,EDN1,FCER1G,FCMR,FGL2,GADD45A,GIMAP7,GLI1,ICAM1,IRF1,ITGB3,ITGB4,MAML2,PLCG2,PRKAR2B,PRKCQ,RASSF4,RCSD1,RGCC,ROCK1,SFRP5,SREBF1,TFPI2,TGFB1,TRHDE | 1115 (13) |
| YY1 | 5.40e-01 | transcription regulator | NA | 1.50e-01 | NA | 0.0e+00 | ACTA1,ACTA2,ACTC1,ALCAM,ANKRD1,ARID3B,BCL2L1,BCL2L11,BDNF,BMP4,BTG2,BUB1B,CCNA2,CCR5,CD22,CD34,CD93,CDH1,CDKN1A,CDKN2C,CHRDL1,CIITA,COL19A1,COL1A1,CRYAB,CXCL12,CXCR4,CYBB,DDIT4,DMPK,DNAJB4,EBF2,EDN1,EGR1,EGR2,FEN1,GADD45G,GFER,GPC3,GRIN2D,HAS2,HIF1A,HLA-DRA,HNRNPC,HOXD4,ID2,ID4,IGFBP5,IL1R1,KDR,KIF11,KIF23,KLF4,MAT2A,MCM7,MKI67,MMP2,MYH2,MYH3,MYH6,MYL1,MYOD1,NOTCH2,PAWR,PDGFD,PDGFRA,PLAGL1,PLK1,PLP1,Pmaip1,PNRC2,POLA1,PRC1,PROX1,PTBP3,RBBP4,RND3,SFXN1,SHC2,SIM1,SLC1A3,SNRPN,SRSF1,Srsf5,STAR,TACC3,TAGLN,TGFBI,TIMP1,TNFRSF10A,TNFRSF4,TNNC1,TNNC2,TNNI1,TOP2A,TPH1,Tpm1,TRA2A,UHRF1,VEGFC,VIM,VWF,WSB1 | 1432 (19) |
| SUMO3 | 6.50e-01 | other | NA | 1.50e-01 | NA | 0.0e+00 | CAV1,CAV2,CCND2,CEACAM1,CXCL10,CXCL16,ENPP3,Ifgga2l1/RGD1309362,IRS1,ISG15,MMP14,MOXD1,Ndp,RNASE4,TNC | 1213 (12) |
| 1,2-dimethylhydrazine | NA | chemical toxicant | NA | 1.50e-01 | NA | 0.0e+00 | ALDH1A3,ALOX12,CASP3,CCND1,CPA3,IL1RL1,MYL1,NR4A1,PER3,PRSS12,PTGS2,RNF152,SPP1,TEF,TNFRSF11B | 930 (11) |
| PIWIL2 | -2.20e-01 | enzyme | NA | 1.50e-01 | NA | 0.0e+00 | BCL2L1,CABLES1,CCND1,CXXC4,MAP1A | NA |
| CCAR1 | 3.10e-01 | transcription regulator | NA | 1.50e-01 | bias | 1.0e-02 | CEBPD,PPARG,RGS2,SPHK1 | 899 (7) |
| ZMYND10 | 6.30e-01 | other | NA | 1.50e-01 | NA | 1.0e-02 | MMP14,MMP19,MMP2,THBS1 | NA |
| BMP5 | -9.60e-01 | growth factor | NA | 1.50e-01 | NA | 3.0e-02 | CCND2,MC2R,SNAI1,STAR | NA |
| SMARCD1 | -2.60e-01 | transcription regulator | NA | 1.50e-01 | bias | 3.0e-02 | BTG2,CDKN1A,FOXP3,TMPRSS2 | NA |
| GLRX | 8.30e-01 | enzyme | NA | 1.50e-01 | NA | 5.0e-02 | FGF2,HIF1A,ICAM1,PDGFB | NA |
| sodium arsenite | NA | chemical drug | NA | 1.50e-01 | NA | 0.0e+00 | CCND1,CCND2,CDK6,CDKN1A,CISH,EGR1,EGR3,FKBP5,GADD45A,GADD45B,GCLC,HIF1A,LITAF,MAT2A,NFE2L2,OLR1,PPARG,SLC18A2,SOCS1,SOCS3,SRSF3 | 1336 (17) |
| trichloroethylene | NA | chemical toxicant | NA | 1.50e-01 | NA | 0.0e+00 | ACVR1C,ANPEP,BCL2L1,CASP3,CD47,CDK6,CHP1,CITED2,COL1A1,COL3A1,EGR1,ID2,LOC257642,PLD1,PLS3,PTPRF,SLC16A1,SPARC,YWHAQ | 756 (12) |
| EZR | -1.44e+00 | other | NA | 1.50e-01 | NA | 1.0e-02 | ATF3,BCL2L1,BOP1,CDH1,CDH2,DDIT4,EIF4EBP1,ITGB4,MMP14,MMP2,PTGS2,RPS6KB1 | 1362 (18) |
| miR-24-3p (and other miRNAs w/seed GGCUCAG) | NA | mature microRNA | NA | 1.40e-01 | bias | 2.0e-02 | ACVR1B,CASP1,CASP3,CCNA2,DUSP1,E2F2,FEN1,MAP2K4,MAPK14,Pmaip1,TGFB1 | NA |
| cinnamaldehyde | NA | chemical toxicant | NA | 1.40e-01 | NA | 3.0e-02 | Akr1b10,BCL2L1,Ccl2,DDIT4,DUSP6,EGR1,GCLC,HSPA1A/HSPA1B,IDH3A,JUND,MAP2K2,MKI67,NFE2L2,PDK4,PNPLA2,PPARG,PRDM16,PTGS2,SELE,SLC2A1,TGFB1I1,TLR4 | NA |
| ZNF32 | 6.00e-02 | transcription regulator | NA | 1.40e-01 | bias | 1.0e-02 | ALCAM,ALDH1A1,LEPR,PROM1 | 702 (7) |
| GW 5074 | NA | chemical drug | NA | 1.30e-01 | NA | 3.0e-02 | ATP6AP2,BCL2L1,PTGS2,SERPINE1 | NA |
| ANGPT1 | 1.60e-01 | growth factor | NA | 1.30e-01 | NA | 0.0e+00 | ACTA1,ADAMTS1,ADAMTS5,ADAMTS9,ALCAM,ANGPT2,APLN,BCL2L1,CCND1,COL3A1,DUSP1,DUSP5,ICAM1,IL1R1,JAG1,MYH7,SELE,TEK,VCAM1 | 1251 (19) |
| melatonin | NA | chemical - endogenous mammalian | NA | 1.30e-01 | NA | 4.0e-02 | ALOX15,ASRGL1,BCL2L1,CASP1,CASP3,Ccl2,CDKN1A,COL1A1,CXCL10,DDAH2,EDN1,EIF2AK3,GFAP,GJB2,HIF1A,ICAM1,IGF1,IL2RB,IRS1,IRS2,KRT19,MAP1LC3B,Mt1,NCAM1,NFE2L2,NLRP3,PLAT,PTGS2,RUNX2,SELE,SELP,SPARC,SPP1,TLR4,VCAM1,VIM,WNT4 | NA |
| GW501516 | NA | chemical drug | NA | 1.30e-01 | NA | 0.0e+00 | ABCA1,ACADL,ACSL1,ADIPOQ,APOD,CCL21,CCND1,CDKN1A,CHKA,COL5A1,Cox8b,ECH1,F3,FGFR1,GPD1,ICAM1,IGFBP5,IGFBP6,KRT19,LIPG,LPIN1,LPL,OLAH,PDK4,PLAT,PPARD,PTGS2,SLC27A1,THBS1,UCP3 | 1289 (20) |
| EFEMP1 | -4.60e-01 | enzyme | NA | 1.30e-01 | NA | 0.0e+00 | ADAM17,CDH1,FBLN5,SERPINE1,SMAD7,VIM | 1156 (17) |
| KIT | -1.29e+00 | transmembrane receptor | NA | 1.30e-01 | NA | 0.0e+00 | BCL2L1,BCL2L11,C3AR1,Ccl2,CCND2,CD44,CD53,CISH,CMA1,CPA3,CSF2RB,CXCL10,CXCR4,EML1,ETV1,GPR34,HDC,ICAM1,Ifi47,IL15RA,IL17A,IL17RA,IL2RA,IRF1,ITGA2B,ITGAE,ITGB2,KIT,KITLG,LTB4R,MGST2,MITF,PRKCQ,PSTPIP2,PTPN6,RAB32,SNAI2,SOCS1,SOCS3,SPP1,STAT1 | 1412 (16) |
| PTPN11 | 4.00e-01 | phosphatase | NA | 1.30e-01 | NA | 0.0e+00 | ATP2A2,BCL2L1,CCND1,CDKN1A,CDKN2C,CSF1,CSF1R,CSF3R,CYBB,EGR1,FCGR1A,FCGR2B,FCGR3A/FCGR3B,GAB1,IFI16,ISG15,KDR,KIT,LYN,MET,MMP19,NCF2,OASL,SFTPB,SOCS3,SOX7,SPDEF,Tcf7,TNFRSF1B,TP63 | 1336 (21) |
| EML4-ALK | NA | fusion gene/product | NA | 1.20e-01 | NA | 0.0e+00 | ARF1,BCL2L11,CASP3,CD44,CDC14B,CDH1,CDKN1A,CDKN2C,COL3A1,COL5A2,DUSP1,DUSP6,EGR1,ERBB3,GADD45B,HIF1A,IL15RA,IRF1,IRF4,MET,MITF,MMP2,NNMT,OCLN,PDGFC,PIK3R1,PPARG,RAB27A,SERPINE1,SOCS3,SPARC,STAT6,THBD,TLR2,VCAN | 1417 (20) |
| MEG3 | NA | other | NA | 1.20e-01 | NA | 0.0e+00 | ACTA2,CDH1,COL1A1,FN1,HIF1A,VIM,ZEB2 | 1427 (18) |
| ONO 1301 | NA | chemical reagent | NA | 1.20e-01 | NA | 0.0e+00 | CD86,CDH1,HGF,ICAM1,MET | 657 (7) |
| PPP3R1 | 2.30e-01 | phosphatase | NA | 1.10e-01 | NA | 1.0e-02 | ACTR3B,ADRB2,ATP2A2,BCL3,CACNB2,CCND2,CYYR1,DLK1,Fam169b,GIMAP4,IL1RL1,MYH7,Scd2,SCNN1G,SFTPB,SHROOM2,SLC7A10,Zfp882 | NA |
| 10-(6’-ubiquinonyl)decyltriphenylphosphonium | NA | chemical drug | NA | 1.10e-01 | NA | 1.0e-02 | ADIPOQ,DPP4,KDR,NFE2L2,PRDX4,PTGS2,SOCS3,UQCC3 | 1370 (20) |
| NEIL2 | 2.00e-01 | enzyme | NA | 1.10e-01 | NA | 1.0e-02 | BCL6,C3,Ccl2,Ccl7,CCR1,CCR3,CRP,CSF1,CXCL10,GAPDH,IL1R1,IL1RN,IL7,ITGB2,MYOD1,PTGS2,RIPK2,SELE,TLR2,TLR4,TLR5,TLR7 | 963 (10) |
| N-formyl-Met-Leu-Phe | NA | chemical reagent | NA | 1.10e-01 | NA | 0.0e+00 | CCR5,CORO1C,CYBB,FCGR1A,ISG15,ITGB2,KIF11,KIF23,MSN,NFKBIA,NFKBIB,PTGS2,RAC2,SIRPA,SOCS1,TAGLN2,TYRO3 | 738 (13) |
| SMO | -7.30e-01 | G-protein coupled receptor | NA | 1.10e-01 | NA | 0.0e+00 | ALCAM,BGN,CCND1,COL27A1,CXXC4,DIO1,DIXDC1,FOXC2,FZD2,GLI1,GLI2,LEF1,LGR5,LIMD2,LUM,MYF5,MYOD1,NCAM1,NKD1,NRCAM,NRP2,OGN,PPARG,PRDM1,PRSS35,PTCH1,RUNX1,SOX18,TGFA,TNFRSF10A,VCAM1,VCAN,WNT6 | 1415 (20) |
| glutamine | NA | chemical - endogenous mammalian | NA | 1.10e-01 | NA | 0.0e+00 | ACTA2,ACTC1,ASNS,BCAT1,BCL2L11,CCND1,CDKN1A,COL1A1,DDIT4,DUSP1,FN1,GADD45A,HIF1A,HK1,HSPA1A/HSPA1B,ICAM1,IDH1,IL17A,KLF4,MYH6,NFKBIA,NR4A1,OAZ1,PDGFB,PICK1,PROM1,PTGS2,SLC16A1,SNAI2,SOX10,SRSF1,THBS2,TUBB4A,VCP,VIM | 1406 (18) |
| metronidazole | NA | chemical drug | NA | 1.10e-01 | NA | 0.0e+00 | ABCC3,ABI1,ACTA2,AGMO,AK1,ALCAM,APOD,BACH1,BMP1,BMP4,CCND1,CD9,CITED2,COL3A1,CRYL1,CSF1,DNAJB4,EXTL3,GPM6A,IGFBP5,IL10RA,IL17A,IL1R1,KHDRBS3,LAMP2,LGALS1,MCOLN1,MMP2,NUAK1,PTPRZ1,RHOA,RTN4RL1,SLC7A8,SLCO4A1,SPP1,ST3GAL6,SYNJ1,TMC7 | NA |
| CX3CR1 | -1.67e+00 | G-protein coupled receptor | NA | 1.10e-01 | NA | 4.0e-02 | ABHD14A,ACER2,ANXA5,ARL13B,ARL3,CCDC39,Ccl2,CD36,CHKA,CRYAB,CRYGA,DYNC2H1,EGR1,EMP1,EXOC4,FGF2,FN3KRP,GLI2,GPRASP1,GRIPAP1,HAP1,ICAM1,IGF1,KIF21B,LARS2,LRRC2,MAP1B,MAP7,MSI1,MSR1,NICN1,OCRL,PITPNM3,PTCH1,RP1,SNCA,STX3,TGFB1,WDPCP | NA |
| Collagen(s) | NA | complex | NA | 1.10e-01 | NA | 1.0e-02 | BCL3,C3,C3AR1,C5AR1,CREB3L1,EDEM1,FN1,HERPUD1,LAMP2,SELP,SERPINH1,SNAI1,THBS1,TNC | NA |
| 8-hydroxy-2-(di-n-propylamino)tetralin | NA | chemical reagent | NA | 1.10e-01 | NA | 1.0e-02 | CDH1,CDH2,FN1,NOS1,NR4A1,VIM | NA |
| Foxp1 | -6.10e-01 | transcription regulator | NA | 1.00e-01 | NA | 0.0e+00 | BCL2L1,CDS1,CNR1,DAB1,E2F2,EGR2,FOXP3,HOPX,KCNT1,LMO2,MYCN,NGEF,PDPN,RASGRP2,RYR1,SPHKAP | 1015 (13) |
| choline fenofibrate | NA | chemical drug | NA | 1.00e-01 | NA | 2.0e-02 | ACSL1,ADIPOQ,CAV1,CXCL12,F3,HIF1A,NFKBIA,PCSK5,PTPRF,SERPINE1 | NA |
| CETP | NA | enzyme | NA | 1.00e-01 | NA | 1.0e-02 | HERPUD1,LCAT,LPL,NR0B2,PDIA4,PLIN1,PLIN3,PPARG,SREBF1 | NA |
| NR1H3 | 1.90e-01 | ligand-dependent nuclear receptor | NA | 1.00e-01 | NA | 0.0e+00 | ABCA1,ABCG1,ACSL3,ACTA2,ADGRE1,ADRB2,APOD,ATF3,BCL2L1,BUB1B,Ccl2,CCL24,Ccl7,CCNA2,CCNE2,CCR1,CCR3,CCR5,CD47,CDC25B,CDKN1A,CENPF,CFB,CRP,CTSC,CX3CL1,CX3CR1,CXCL10,CXCL16,CYTH1,CYTIP,DHRS9,E2F7,FCGR1A,FGL2,G0S2,GBP4,GLI1,GPAM,GPX3,Gsta4,HK1,IL1RN,IRF8,ITGAL,ITGB3,KIF23,KIF4A,KNL1,KNTC1,LCP2,LPL,LY86,MKI67,Mt1,MYLIP,NFKBIA,NR0B2,NR5A2,PFKFB1,PLK1,PLTP,PPARG,PRC1,PRDM16,PTCH1,PTGS2,RARA,Scd2,SLC16A2,SNAI1,SOCS1,SREBF1,STAR,TOP2A,TRIB1,TSHR,UBC,UHRF1,VCAN,VEGFC | 1406 (20) |
| CDH2 | -1.34e+00 | other | NA | 1.00e-01 | NA | 0.0e+00 | ACTA2,CCND1,CDH1,CDKN1A,ENO2,KCNA5,MYOG,SNAI2,THY1,VIM | 1394 (19) |
| dopamine | NA | chemical - endogenous mammalian | NA | 9.00e-02 | NA | 0.0e+00 | ASIC2,ATF3,ATP1A1,ATP8B1,BCL2L1,BDNF,BTG2,CACNA2D2,CACNG1,Ccl2,Ccl7,CDC14A,CHRNA1,CLCN3,CNR1,CSRNP1,CTSK,CXCL10,EGR1,EGR3,GAD1,GPC3,GPR68,HIF1A,HIVEP3,IFI16,IL17A,KCNA1,KCNJ12,KCNJ13,KCNK1,KCNK2,KCNK6,KLF4,LMOD1,MAP2,NCF1,NOD2,NPR3,NR4A1,NR4A3,PDE10A,PENK,PER1,SCN1A,SCN1B,SLC1A3,SYP,TGFA,TRPV1 | 1378 (21) |
| FOXP1 | NA | transcription regulator | NA | 9.00e-02 | NA | 3.0e-02 | CDKN1A,CSF1R,DPYD,GAP43,GZMB,IRF4,NLGN3,NR5A2,PRDM1,S1PR2,SFRP4,ST8SIA2 | NA |
| zVAD-FMK | NA | chemical - protease inhibitor | NA | 9.00e-02 | NA | 4.0e-02 | ANXA5,ARG1,BCL2A1,BCL2L11,BIRC3,CASP1,CASP3,CDK6,CDKN1A,IL2RA,MAP1LC3B,MLKL,MRC1,VCAM1 | NA |
| HAVCR1 | NA | other | NA | 9.00e-02 | NA | 0.0e+00 | AHR,ANPEP,APBB1IP,B2M,CDK6,CHKA,EGR2,ENO2,ERAP1,FHL3,FSCN1,GLI2,HIF1A,HLF,IL2RA,IRF1,KDM3A,L1CAM,LBP,LOXL2,LYN,MYH10,NFKBIA,PFKFB3,SNAI2,SOCS3,SPARC,STAT1,TMEM45A,TSPAN18 | 1166 (16) |
| THBS2 | -1.36e+00 | other | NA | 8.00e-02 | NA | 1.0e-02 | ALDOA,Ccl2,HIF1A,MMP2,PKM,SLC2A1 | NA |
| BAG1 | 2.80e-01 | other | NA | 7.00e-02 | NA | 0.0e+00 | BCL2L1,BCL2L11,CCND1,CDH1,CDH2,CDKN1A,FKBP5,FRK,GADD45A,NEDD4L,PTGS2,RAB27A,SNAI1,SNAI2,TWIST1,UAP1,VIM | 1491 (17) |
| phorbol 12,13-didecanoate | NA | chemical toxicant | NA | 7.00e-02 | NA | 1.0e-02 | CALCR,CDH1,CDKN1A,CSF1,DUSP1,HSF2,MAX,PRKCD,PRKCE,SGK1 | NA |
| AHR | -1.87e+00 | ligand-dependent nuclear receptor | NA | 7.00e-02 | NA | 0.0e+00 | A2M,ABCC4,ACKR3,ACP5,ACTA2,ADAM19,ADAMTS2,ADAMTS5,ADGRE1,AHRR,AIF1,ALDOA,ALOX5,Aox2,ATP1B1,BTG2,CADM4,CAPN5,CARD11,CASP8,Ccl2,CCL21,CCNA2,CCND1,CCR5,CD28,CD36,CD84,CDC25B,CDH1,CDH2,CDK2,CDKN1A,CDKN2C,CDO1,CDON,CERS4,CERS6,CGREF1,CHD7,CHI3L1,COL11A1,COL12A1,COL13A1,COL14A1,COL16A1,COL1A1,COL27A1,COL3A1,COL5A1,COL5A2,COL6A3,COLQ,CRP,CRYAB,CSF2RB,CTNNAL1,CX3CR1,CXCL10,CXCL13,CYP1B1,CYP2S1,DACT2,DCLK3,DCN,DIO1,DNAJB1,DUOX2,DUSP6,E2F8,EBF1,EDN1,EGLN1,EGLN2,EGR2,ELN,ELOVL5,EMILIN2,ENPEP,ENTPD1,ESRRG,FADS3,FBLN5,FBN1,FBN2,FGF9,FMO2,FN1,FOXP3,GADD45A,GHITM,GPAM,GREM1,HDAC9,HECTD2,HEY2,HIF1A,HSP90AA1,IL17A,IL1R1,IL2RB,IL34,IRF1,IRF4,ITGA5,ITGA6,ITGAD,ITGBL1,JAG1,KIT,LAMA3,LAMC2,LBP,LTBP1,LTBP2,LYST,MATN2,MMP2,MPZ,Mt1,MYH7,MYL2,NEDD9,NFE2L2,NID1,NLRP3,NMT2,NNMT,NRG4,OCLN,OLFML1,Pcp4l1,PDGFB,PDGFRA,PLAT,PLK1,PMM1,PMP22,POLA1,PPARG,PRKCQ,PTGS2,PTX3,PXDN,RASGRP1,RBL1,SDC1,SEMA3A,SEMA3F,SERPINE1,SIM1,SLAMF1,SLC1A1,SLC1A4,SLC25A51,SLC2A1,SNAI1,SNAI2,SOCS3,SPP1,SREBF1,STEAP2,TGFB1,TGFBI,THBS1,TIPARP,TLR5,TNFRSF19,TUBA8,UGCG,VEGFC,VIM | 1490 (16) |
| EGLN3 | 2.40e-01 | enzyme | NA | 7.00e-02 | NA | 0.0e+00 | ADIPOQ,BCL2L11,Ccl2,EGLN2,HIF1A,HK1,LGR5,LPIN1,MYOG,OCLN,SLC2A1,TNFRSF11B,VCAM1 | 1508 (22) |
| mir-497 | NA | microRNA | NA | 6.00e-02 | bias | 5.0e-02 | BTRC,CCND1,EGLN2,MAPK3 | NA |
| CBFB | 1.05e+00 | transcription regulator | NA | 6.00e-02 | NA | 0.0e+00 | BCL2L11,CCR5,CDH1,CSF1R,FOXC2,FOXP3,ICAM1,IKZF2,IL2RA,IL2RB,ITGA2B,ITGAE,ITGAL,LTB4R,NRP1,OCLN,PDE3B,PPARG,PRRG1,RUNX1,RUNX2,SNAI2,SPP1,STAT6,TLR7,TNFAIP8L2,TNFRSF4,TWIST1,WNT10B | 1223 (15) |
| GPRC6A | NA | G-protein coupled receptor | NA | 6.00e-02 | NA | 2.0e-02 | ADGRE1,EGR1,FOXO1,PLIN1,PNPLA2,PRDM16 | NA |
| arsenic trioxide | NA | chemical drug | NA | 5.00e-02 | NA | 0.0e+00 | ARL6IP1,ATP1B1,ATP1B2,ATP6V0B,ATP6V1A,ATP6V1F,BACH1,BCAT1,BCL2A1,BCL2L1,BLVRB,CACNA1B,CASP8,CCND1,CD44,CDC25B,CDK6,CDKN1A,COX6B1,DHCR7,EBP,ECT2,EIF2AK3,ETV5,FADS1,FN1,GCLC,GLI1,GLI2,GLRX,GSR,HBA1/HBA2,HIF1A,HRAS,HSPA2,HSPE1,IL17A,IP6K2,IRF1,KAT5,KIF11,LMAN2,LMO2,LSS,MADD,MAF,MAP2K4,MAPK4,MCM7,MSMO1,MSN,NCF1,NDFIP2,NDUFA1,NDUFA7,NDUFC1,NDUFC2,NFE2L2,NFKBIA,NR2F2,PDIA4,PFKFB1,PIR,PPARG,PRAM1,PRPF4B,PTCH1,PTGS2,PTPRC,RAB31,RAB8A,RASA2,RHOA,SHMT1,SLC20A1,SLC25A6,SREBF1,TMOD1,TNFRSF10A,TP63,TYMS,UQCR10,UQCR11,VCP,ZDHHC17 | 1459 (19) |
| farnesyl pyrophosphate | NA | chemical - endogenous mammalian | NA | 5.00e-02 | NA | 0.0e+00 | ABCA1,ICAM1,LIPG,PTGS2,SELP,SERPINE1,TGFB1,VCAM1 | 1305 (17) |
| CDH3 | -1.16e+00 | other | NA | 5.00e-02 | NA | 1.0e-02 | BICC1,CARD11,CDH2,EML1,FKBP10,LIMCH1,OLFM1,ST3GAL1,TEK,WSCD1 | NA |
| EGR2 | -2.62e+00 | transcription regulator | NA | 4.00e-02 | NA | 0.0e+00 | ABHD5,ACVR1,AHNAK2,AHR,ANKRD55,ARHGAP24,ATF3,BCL2L11,BCL6,BHLHE40,CDH6,CDK14,CDKN1A,CHKA,CHST7,CISH,COL11A1,CSF1R,CTSE,CYB5R2,DHCR7,DLG3,DMBT1,DOK2,DTX1,EGR1,EGR2,EIF5B,ELOA,EMB,EPHA4,FGF2,GAD1,GALNT7,GNB4,GRIA2,HOMER1,ID2,ID4,IL17A,IL4I1,ITGAE,ITGB3,KDR,KITLG,LAMA2,LGALS1,MAG,MAP2,MAP7,MME,MPZ,MR1,MVD,MVK,MYO1D,NAB2,NCMAP,NECTIN1,NFIL3,NRP2,PDE4A,PDE8A,PLCL1,PLEKHA8,PMP2,PMP22,PRDM1,PRKCD,PRX,RARA,RARG,RASAL1,RFLNB,RGL1,RNPEP,RRAD,S100A4,SART1,SCIMP,SLC16A1,SLC1A3,SLC39A4,SLC4A3,SOCS1,SOCS3,SPECC1,STAR,STK3,TBC1D9,Tgoln1,TMEM141,TNFRSF8,UCP3,ZBTB16,ZBTB20,ZEB2 | 1556 (21) |
| DDR1 | -6.30e-01 | kinase | NA | 4.00e-02 | NA | 0.0e+00 | BCL2L1,Ccl2,CDH1,CDH2,CDKN1A,COL1A1,COL3A1,ELN,MMP14,MMP2,VCAM1 | 1094 (21) |
| seocalcitol | NA | chemical drug | NA | 4.00e-02 | NA | 1.0e-02 | ANKRD1,BCL2L1,BLOC1S1,CACNA1D,CDKN1A,CEACAM1,GADD45A,IGFBP5,NINJ1,PDLIM7,PEX13,PTGS2,RHOA,SGK1,SKP2,SNU13,SSPN,STAT6,TMPRSS2 | 1503 (24) |
| tranylcypromine | NA | chemical drug | NA | 4.00e-02 | NA | 5.0e-02 | BDNF,CDKN1A,CTSK,CXCL10,HIF1A,NTRK2,PDE4A | NA |
| LOXL2 | -1.07e+00 | enzyme | NA | 4.00e-02 | NA | 2.0e-02 | CDH1,FN1,MMP14,OCLN,SNAI1,VIM | NA |
| FMR1 | -5.10e-01 | translation regulator | NA | 3.00e-02 | NA | 0.0e+00 | ALDOA,ATF3,ATP6V1E1,BCAS1,CACNA1D,CACNB4,CAMK2A,CFL1,COL5A2,CORO2B,CPQ,CYP1B1,DLG3,DNM1,EGR3,GAP43,GAPDH,GRIA2,HERC2,IGFBP4,MAP1B,MRPL22,MRPL23,MRPL34,MRPL41,MRPS18B,MRPS23,MRPS25,NAAA,NDN,NPEPL1,PCDHGA6,PFN1,PLAT,PPIA,QPCT,RASGRF1,RPL14,RPL17,RPL18,RPL22,RPL23,RPL28,RPL37A,RPS10,RPS11,RPS15,RPS15A,RPS16,RPS18,RPS2,RPS24,RTN4RL1,SLC38A1,SMOC1,SPON1,ST3GAL6,STX11,SV2B,SYP,TAGLN2 | 416 (5) |
| POR | 1.60e-01 | enzyme | NA | 3.00e-02 | NA | 0.0e+00 | ABCA1,ABCC3,ACADL,ACSL1,ACTA1,ACTG1,AHR,ALDH1A1,ANTXR2,ANXA5,APCDD1,ASNS,BDH1,CD36,CD74,CIITA,CLDN3,CPA3,CYP39A1,CYP7B1,DHCR7,ELOVL1,ELOVL5,ETHE1,FADS2,FGF1,FLVCR2,FOXC1,GADD45B,GBP2,HIF1A,HLA-A,HLA-DQA1,HLF,HSD17B12,KDR,LGALS1,LPL,LSS,MAP3K6,MSMO1,Mt1,MVD,MVK,Naip1 (includes others),NR0B2,NRG4,PDK4,PFKFB3,PLA2G7,PNPLA7,PPARG,RAB30,Scd2,SDC4,SECISBP2L,Slco1a4,STAT1,TMEM176A,TMEM229B,UGDH | 1186 (13) |
| EIF4E | 4.30e-01 | translation regulator | NA | 3.00e-02 | NA | 0.0e+00 | ADAMTS15,ATOX1,B2M,BCL2L1,C3AR1,CBLC,Ccl2,CCND1,CCR5,CDC34,CDK2,CDKN1A,CSF1R,CX3CR1,CXCL16,CYBA,CYBB,DPYD,EGLN2,EIF4EBP1,Fcrls,FGF2,FN1,FREM2,GPR65,GPX3,HIF1A,HLA-A,HRAS,IFI16,IGFBP4,IL15RA,IL33,LAT2,LSM10,LSM4,MIA,NCK2,NFKBIA,NHP2,NRP1,P2RY12,PRDX5,PTPRC,PVALB,RPL35,RPL37A,SIRT2,SKP2,SLC2A5,SLCO2B1,SNAI1,SNRPA,SPHK1,TGFA,TGFBI,TMEM119,TNC,TP53BP2,TRIP6,UBA7,VEGFC,VSIR | 1391 (18) |
| CTBP1 | 2.00e-01 | enzyme | NA | 2.00e-02 | NA | 0.0e+00 | ABCA1,ACKR3,BRCA2,C8orf44-SGK3/SGK3,CDH1,CDKN1A,CSF1R,CYP26B1,DHCR7,ENC1,FKBP5,FSCN1,MIA,OCLN,SMAD6,THBS1,VCAN | NA |
| PAX2 | NA | transcription regulator | NA | 2.00e-02 | NA | 1.0e-02 | ADAM10,ALDH1A3,DKK3,ITGB3,KIT,LGR5,MITF,SFRP2,SOX8,WNT4,WNT5A | NA |
| Collagen type III | NA | complex | NA | 2.00e-02 | NA | 2.0e-02 | CDH1,ITGA2,ITGA5,ITGB3 | NA |
| ELF1 | -8.50e-01 | transcription regulator | NA | 2.00e-02 | NA | 4.0e-02 | BRCA2,CD1D,CDK11A,CITED2,FCER1G,IL2RA,NCF2,TEK,UNC13D | NA |
| mercuric chloride | NA | chemical toxicant | NA | 1.00e-02 | NA | 3.0e-02 | CDH1,CDH2,CDKN1A,GADD45A,GCLC,GSR,Gsta4,HSP90AA1,HSPA1A/HSPA1B,Mt1,SPP1 | NA |
| tributyltin | NA | chemical reagent | NA | 1.00e-02 | NA | 0.0e+00 | ABCA1,ABCG1,ACSL1,AHR,CA3,CCNE2,COL1A1,COL3A1,COL5A1,COX4I1,Crip2,CYP26B1,DCN,DOCK8,EBF2,F2RL1,Fmnl1,FN1,GGCT,HSP90AA1,HTRA3,IDH1,IL33,INHBA,ITGA3,ITGB3,ITGB7,LPL,MITF,NDUFV1,NGEF,NRXN2,PARM1,PDGFRA,PDK4,PLIN4,PPARG,RCAN2,SLCO4A1,SNTB1,SPN,SREBF1,STAT1,THBS1,THBS2,TNC | 1187 (21) |
| LDLR | -1.30e-01 | transporter | NA | 1.00e-02 | NA | 0.0e+00 | ABCA1,ABCG1,ALCAM,ALDH9A1,APOBEC1,AXIN2,BCL2L1,BGN,BUB1B,Ccl2,Ccl7,CCNA2,CCND1,CCNE2,CCR1,CCR3,CCR5,CD36,CD47,CDC25B,CDKN1A,CENPF,CFB,CTSC,CX3CL1,CX3CR1,CYP27A1,CYP7B1,CYTH1,CYTIP,DHRS9,DUSP1,E2F7,EGR1,ENG,F3,FADS2,FCGR1A,FGL2,FOXP3,G6PD,GADD45G,GAPDH,GATM,GJA5,GPAM,GPI,H6PD,ICAM1,IER3,IL1RN,ITGB3,KIF23,KIF4A,KNL1,KNTC1,LCP2,LPL,LY86,MINPP1,MKI67,MMP14,MMP2,MSR1,MVD,PKIB,PLK1,PLTP,PPARG,PRC1,PRKAA1,RUNX2,SELE,SLC2A1,SOCS1,SPP1,SREBF1,TOP2A,TRIB1,UBC,UBE2D3,UCP3,UHRF1,VCAM1,VCAN | 1353 (18) |
| PLCG2 | -8.00e-01 | enzyme | NA | 1.00e-02 | NA | 0.0e+00 | ACSL1,ACSL3,BCL2A1,Ccl2,Ccl7,CD36,CD74,CD9,CTSK,CXCL10,FGF2,FOXO1,HLA-A,HLA-DQA1,ICAM1,IFI16,IFITM3,ISG15,LPCAT1,LPL,MMP19,PLA2G4A,PLCG2,PTGS2,PTPRC,SPP1,STAT1 | 1489 (15) |
| 15(S)-HETE | NA | chemical - endogenous mammalian | NA | 1.00e-02 | NA | 1.0e-02 | ABCG1,EGR1,F3,FGF2,MAPK3,MMP2,PPARG,PTGS2 | 1408 (21) |
| camptothecin | NA | chemical drug | NA | 1.00e-02 | NA | 0.0e+00 | ACTA2,ADO,AEN,AK4,ALDOA,ANXA2,ARAP2,ARFGAP1,ATF3,BAMBI,BCL11A,BCL2A1,BCL2L1,BIRC3,BRCA2,BTG2,BTG3,BTK,CASP1,CASP3,CASP8,Ccl2,CCND1,CCR1,CCRL2,CD1D,CD200,CD22,CD300C,CD47,CD48,CD53,CD83,CD86,CD93,CDK2,CDK6,CDKN1A,CHAC1,CHST11,CLTB,CREB1,CSF1,CSNK1D,CTSS,CXCR5,DNAJA1,DUSP10,DUSP6,EDN1,EEF1A1,EGR2,ENC1,ENO3,F2RL1,F3,F5,FADD,FCGR2B,FGL2,FLI1,FOXC1,FOXO1,FSCN1,FXN,GADD45A,GADD45B,GADD45G,GAMT,GAPDH,GBP2,GPI,GPNMB,GRK5,GSR,HIF1A,HLA-A,HLA-DQA1,HSP90AA1,HSPA1A/HSPA1B,HSPA2,HUS1,ICAM1,IER5,IFI16,IL10RA,IL15RA,IL16,IL17RA,IL18R1,IL2RA,IMP3,IQGAP2,IRF1,KLHL21,LIMCH1,LITAF,LPIN1,LY75,MAD1L1,MAD2L1BP,MAFF,MAP2K4,MARCKSL1,Mt1,MTMR1,MYO10,MYO18A,MYO5A,NECTIN1,NFKBIA,NLRP3,NR4A1,NR4A2,NRP1,OPTN,OSR2,P2RY10,PCBP4,PDLIM7,PIK3C2B,PIK3CG,PIP4K2B,PLD1,PLD2,PPIA,PPP3CA,PRKAB1,PRKAR2B,PRKCI,PRKDC,PSD4,PSTPIP1,PTGES,PTGS2,PTP4A2,PTX3,PVALB,PYCARD,RARA,RASGRP2,RBL1,RDX,RGS14,RIPK2,RSAD2,SDC1,SDC4,SELE,SELP,SERPINB9,SERPINE1,SERPINH1,SIAH2,SIPA1,SIPA1L1,SNTB2,SOCS1,SOWAHC,SPP1,STAT5B,STK3,STX11,SYK,TAGLN2,TBCC,TGFB1,TGFBI,THBD,TLR2,TNFAIP6,TNFRSF10A,TNFRSF1B,TNK2,TPBG,TRA2A,TRAF5,TRIB1,TUBB,TWF2,UGCG,VAV2,VAV3,VCAM1,WNK1,ZFP36L1,ZNF281,ZNF532 | 1288 (13) |
| miR-508-3p inhibitor | NA | chemical reagent | NA | 0.00e+00 | NA | 0.0e+00 | CDH1,CLDN1,SERPINE1,SNAI1,TWIST1,VIM | NA |
| UGDH | -1.63e+00 | enzyme | NA | 0.00e+00 | NA | 0.0e+00 | BCAN,CDH1,FADS2,HAS2,LIPG,LPL,TNC | NA |
| NGFR | -2.30e-01 | transmembrane receptor | NA | 0.00e+00 | NA | 0.0e+00 | A2M,BDNF,CCNA2,CCND1,CDK2,DHCR7,GFAP,GRIA2,HPSE,IL1RL1,NCAM1,NR0B2,PLAT,SERPINE1,SORT1 | 1437 (21) |
| ANLN | -7.70e-01 | other | NA | 0.00e+00 | bias | 0.0e+00 | ACER2,AEN,ANK1,BTG2,CDKN1A,CYP26B1,EDA2R,GAL3ST4,GOLGA4,PHLDB3,PRAG1,PSTPIP2,RRAD,SESN1,SULF2,TCEA3,TNFRSF10A,VWCE | NA |
| RTKN | -4.50e-01 | other | NA | 0.00e+00 | NA | 0.0e+00 | BCL2A1,BCL2L1,BIRC3,CDH1,CDH2,VIM | 1071 (11) |
| CHADL | -9.00e-02 | other | NA | 0.00e+00 | NA | 0.0e+00 | Ccl2,CDKN1A,COL2A1,CRYAB,CSPG4,DMP1,FAM107A,MET,NCF1,PTX3,SMPD3,VCAM1 | NA |
| trametinib | NA | chemical drug | NA | 0.00e+00 | NA | 0.0e+00 | ETV5,GPNMB,IFIT1,ISG15,MAF,MITF,MX1,MYBPH,MYOG,PHLDA1,SNAI2,SOCS3,TNNI1 | 1393 (22) |
| candesartan cilexetil | NA | chemical drug | NA | 0.00e+00 | NA | 0.0e+00 | CYBA,HGF,NOX1,NOX4,NPR3,TGFB1 | 742 (10) |
| N-lauroyl-L-phenylalanine | NA | chemical reagent | NA | 0.00e+00 | bias | 0.0e+00 | GADD45G,KLF3,MARK1,NR4A1 | NA |
| 3-hydroxymorphinan | NA | chemical - endogenous mammalian | NA | 0.00e+00 | bias | 0.0e+00 | EGF,SORT1,TGFA,TGFB1 | NA |
| APLNR | -1.86e+00 | G-protein coupled receptor | NA | 0.00e+00 | NA | 0.0e+00 | CDH1,CDH2,GATA4,MYL2,SNAI1,SNAI2,TBX5,THBS1,VIM | 1340 (20) |
| ZHX2 | 4.60e-01 | transcription regulator | NA | 0.00e+00 | NA | 1.0e-02 | HDC,HIF1A,KDM3A,PFKFB3,RUNDC1,WSB1,ZEB2 | NA |
| GC-GCR dimer | NA | complex | NA | 0.00e+00 | bias | 1.0e-02 | ADRB2,ANXA1,BCL2L11,DUSP1,IL1RN,NFKBIA,PC,PDK4,PFKFB1,PIK3R1,SLC37A4 | NA |
| bisphenol A diglycidyl ether | NA | chemical reagent | NA | 0.00e+00 | NA | 1.0e-02 | ACTA2,CDH1,EGLN1,EGLN2,ICAM1,SERPINE1 | 1116 (12) |
| LDL-cholesterol | NA | complex | NA | 0.00e+00 | NA | 1.0e-02 | CXCR4,ICAM1,SYP,THBD | 1045 (11) |
| UTRN | -6.30e-01 | transmembrane receptor | NA | 0.00e+00 | NA | 1.0e-02 | ACTG1,BMP4,MYBPC2,UTRN | NA |
| Atrial Natriuretic Peptide | NA | group | NA | 0.00e+00 | NA | 1.0e-02 | ADIPOQ,EDN1,NPR1,NPR2,SERPINE1,TNC | NA |
| MARCKSL1 | -2.16e+00 | other | NA | 0.00e+00 | NA | 2.0e-02 | ACTA1,CDH1,MYH7,SCN5A | NA |
| ULK1 | -5.00e-02 | kinase | NA | 0.00e+00 | NA | 2.0e-02 | CASP1,CASP3,CNTN2,TUBB4A | NA |
| IFNGR | NA | complex | NA | 0.00e+00 | NA | 2.0e-02 | COL1A1,FN1,IRF1,SOCS3 | NA |
| LRP2 | 2.90e-01 | transporter | NA | 0.00e+00 | NA | 2.0e-02 | BMP4,CA3,DAB2,NLRP3 | NA |
| SNAP23 | 3.00e-01 | transporter | NA | 0.00e+00 | NA | 2.0e-02 | F2RL3,ITGA2B,SELP,TAGLN | NA |
| tosedostat | NA | chemical drug | NA | 0.00e+00 | bias | 2.0e-02 | ASNS,ATF3,CDKN1A,CHAC1,DDIT4,FYN,GADD45A,RETN,SDC1,SLC38A2 | NA |
| GPR15LG | NA | cytokine | NA | 0.00e+00 | NA | 3.0e-02 | CIITA,COQ2,CSF1,HSD3B7,IFIT1,MAFF,PLA2G4E,RAB7B,SEMA3E,SOCS3,SREBF1,TXNRD3 | NA |
| estrone | NA | chemical - endogenous mammalian | NA | 0.00e+00 | NA | 3.0e-02 | IGF1,IRS1,IRS2,PIK3R1,SERPINE1,SYP | NA |
| PYY | NA | other | NA | 0.00e+00 | NA | 3.0e-02 | ABCC8,CACNA1D,IRS2,MAFA,OCEL1,PPARG | NA |
| NPPC | 2.00e-01 | other | NA | 0.00e+00 | NA | 3.0e-02 | CDH2,CHST11,CHST3,EDN1,PPARG,XYLT1 | NA |
| fingolimod phosphate | NA | chemical - endogenous mammalian | NA | 0.00e+00 | NA | 3.0e-02 | HAS2,SERPINE1,SPHK1,THBS1 | NA |
| ANKS6 | -4.20e-01 | other | NA | 0.00e+00 | NA | 3.0e-02 | ADGRE1,ARG1,Ccl2,FN1 | NA |
| LTBP4 | -1.60e-01 | growth factor | NA | 0.00e+00 | NA | 3.0e-02 | BMP4,GREM1,ID2,TGFB1 | NA |
| SLIT2 | 2.90e-01 | other | NA | 0.00e+00 | NA | 3.0e-02 | BCL2L1,BTRC,CDH1,SNAI1 | NA |
| RNF138 | -2.00e-01 | enzyme | NA | 0.00e+00 | NA | 4.0e-02 | BCL2L1,BIRC3,CCND2,GADD45B,ICAM1,IER3,PLK3,SPECC1 | NA |
| APOH | 4.30e-01 | transporter | NA | 0.00e+00 | NA | 4.0e-02 | CD36,CD83,CD86,F3,SELE | NA |
| HLF | 8.60e-01 | transcription regulator | NA | 0.00e+00 | NA | 4.0e-02 | AQP4,HIF1A,HLF,LMO2,PER1 | NA |
| dopamine receptor | NA | group | NA | 0.00e+00 | NA | 5.0e-02 | GAD1,NR4A1,NR4A2,NR4A3 | NA |
| PNU282987 | NA | chemical reagent | NA | 0.00e+00 | NA | 5.0e-02 | IRS2,MAFA,PPARD,SREBF1 | NA |
| USP17L2 (includes others) | NA | peptidase | NA | 0.00e+00 | bias | 5.0e-02 | ALDH1A1,KIT,KLF4,PROM1 | NA |
| manassantin B | NA | chemical - endogenous non-mammalian | NA | 0.00e+00 | bias | 5.0e-02 | CEBPD,HIF1A,PPARG,SREBF1 | NA |
| tacrolimus | NA | chemical drug | NA | 0.00e+00 | NA | 0.0e+00 | ABLIM1,ACTA1,ADAM19,APOD,ATP2B4,BATF,BCL2L1,BCL2L11,CALB1,CASP3,Ccl2,CCND1,CCR3,CD200,CD36,CD48,CD6,CD74,CISH,CKM,COL1A1,COL2A1,COL3A1,CXADR,CXCL10,CXCR4,CYBB,DAB2IP,DACH1,DAPK1,DPYSL3,EDN1,EGR1,ELL2,ENC1,ETV1,F5,FKBP5,FLNA,FN1,FOXP3,GAP43,GZMB,HOMER2,IGFBP4,IKZF2,IL16,IL17A,IL1RL1,IL2RA,IL2RB,IL33,IRF4,ITGAE,ITGB7,KCNA1,KCNK3,LBH,MAF,MARCKSL1,MYH10,MYH7,MYOG,NEB,NFAT5,NFATC4,NFKBIA,NOS1,NR4A1,NRP1,OCLN,OSBPL3,PDE3B,PDLIM4,PENK,PIK3R1,PROM1,PTGS2,PTPRF,PTPRJ,Rcan1,RUNX2,SIAH2,SLAMF1,SLC8A3,SMAD7,SPP1,TLE1,TMEFF1,TNC,TNFRSF1B,TNFRSF25,TNFRSF4,VEGFC,WLS | 1684 (17) |
| cerivastatin | NA | chemical drug | NA | -1.00e-02 | NA | 0.0e+00 | CD36,CDKN1A,CNP,COL1A1,CYP1B1,ENPP3,F3,FGF2,FN1,GCH1,ICAM1,ITGAL,ITGB2,ITGB4,MAL,MYH7,NET1,NFYA,PLAT,PPARG,PTGS2,SERPINE1,TGFB1,THBD,TMSB10/TMSB4X,VCAM1 | 1264 (16) |
| caffeine | NA | chemical drug | NA | -1.00e-02 | NA | 0.0e+00 | ACP5,ADORA2A,BDNF,CASP3,CAV1,CDH1,CDKN1A,COX4I1,CTSK,EGR1,F3,FAM89B,HIF1A,MICB,MITF,NR4A1,NTRK2,PPARG,PTGS2,SFTPB,SLC2A1,SNAI1,SREBF1,SRSF3,THBS1,VIM | 1549 (21) |
| cyclosporin A | NA | biologic drug | NA | -1.00e-02 | NA | 0.0e+00 | A2M,A3GALT2,ABLIM1,ACTA2,ADORA2A,ANXA1,ANXA2,APOD,ASNS,ATF3,ATP1A1,BATF,BCAT1,BCL2L1,BCL2L11,BDNF,Bex2/LOC100912195,BGN,BIRC3,CALB1,CASP1,CASP3,CAV1,CCND1,CCR5,CD1D,CD200,CD44,CD6,CD83,CD86,CDH1,CDH11,CDKN1A,COL1A1,CP,CREB1,CX3CR1,CXCR4,CYBA,CYP27A1,DDIT4,EDIL3,EDN1,EDNRB,EGF,EGR1,EGR2,EIF2AK3,EIF6,ELL2,EMP3,F3,F5,FADD,FARP2,FBLIM1,FKBP5,FLNA,FLT3LG,FN1,FOXO1,FOXP3,FREM2,FYN,GCGR,GFAP,GPNMB,GZMB,HERPUD1,HIF1A,HSP90AA1,ICAM1,IER3,IL16,IL17A,IL2RA,IQGAP2,IRF4,ITGAE,ITGAL,ITGB4,ITGB7,KCNA5,KCNK3,KDR,LAMA3,LAMC2,LYN,MAF,MICB,mir-133,MMP14,MMP2,MRC1,MYH10,MYH2,MYH7,MYOCD,NDFIP2,NFAT5,NFKBIA,NOS1,NR4A1,NRCAM,PAM,PDE3B,PKM,PPIA,PSMC1,PTGS2,RAB11B,Rcan1,REL,RUNX1,RUNX2,RXRA,S100A10,S100A11,SELE,SERPINE1,SERPINH1,SIAH2,SLAMF1,SLC8A3,SMPDL3B,SNRPN,SOCS1,SPHK1,SPP1,SREBF1,SRP14,SRSF1,TAGLN,TGFB1,TIMP1,TMSB10/TMSB4X,Tpm1,TRA2A,TSPAN8,TUBB,UTRN,VCAM1,VIM,WNT5A | 1502 (18) |
| ERBB4 | -2.50e-01 | kinase | NA | -1.00e-02 | NA | 0.0e+00 | ACTA1,ACTA2,ADAM19,BDNF,BTG2,CCND1,CDH1,CDKN1A,COL3A1,COL5A2,CXCL12,DUSP1,EGR1,GADD45A,GAP43,HBA1/HBA2,HIF1A,IGFBP4,IGFBP5,NID1,PGK1,PTGIS,PTGS2,SFRP1,SLC1A1,SLC2A1,SOCS3,TBXAS1,THBS1,TNC,VEGFD,WNT10B,WNT2 | 1530 (19) |
| lactacystin | NA | chemical - protease inhibitor | NA | -1.00e-02 | NA | 0.0e+00 | ADRB2,ARHGDIB,ASAH2,ASNS,ATF3,ATP1A1,BCAR1,Ccl2,CCND1,CCND2,CCRL2,CD9,CDKN1A,CFL1,CLIC1,CRYAB,CXCR4,DUSP1,FOXO1,FTL,GCLC,GFAP,GNAI1,HIF1A,HLA-A,IGFBP5,IRS1,IRS2,ITGB4,KCNH2,MAP1B,MMP2,MYCN,NCS1,NEDD9,NFE2L2,NFKBIA,NFKBIB,NOS1,NR4A1,OPTN,PEA15,PEBP1,PFN1,PPIA,PPP5C,PRKCE,PRKCZ,PTGS2,RABIF,RANBP1,RUNX2,SFTPB,SH3BGRL,SIRT2,SLC1A1,SNTB2,SREBF1,STMN1,SYK,TLR2,TUBB4A,VAV3,ZFP36L2 | 1420 (16) |
| HIPK2 | -1.30e-01 | kinase | NA | -2.00e-02 | NA | 1.0e-02 | ANK1,BCL2L1,BDNF,CCND2,CDKN1A,DIAPH3,EGR1,GCLC,GNB3,HBA1/HBA2,HIF1A,ITGA1,ITGB4,NFE2L2,NOX1,RAC2,SPTB,TMEM26,TMEM45B,TRPM5,VIM | NA |
| CBX2 | -9.90e-01 | transcription regulator | NA | -2.00e-02 | NA | 2.0e-02 | AHR,CCND2,CDKN1A,GATA4,NR5A1,RUNX1 | NA |
| 8-(4-chlorophenylthio)-guanosine-3’, 5’-cyclic monophosphate | NA | chemical reagent | NA | -2.00e-02 | NA | 1.0e-02 | ALOX15,Ccl2,Ccl7,CDKN1A,HINT1,PPARG,PRDM16,RHOA | 1485 (23) |
| prostaglandin E2 | NA | chemical - endogenous mammalian | NA | -3.00e-02 | NA | 0.0e+00 | 9930111J21Rik1/Gm12185,ABCG1,ACTA2,ADAMTS1,AHR,AIF1,ALDH1A1,ALOX15,ANGPT2,ANXA2,ARG1,ARHGEF3,ATF3,ATP1A1,BCL2L1,BCL2L11,BIRC3,BTG1,C5AR1,CALCR,CALCRL,CASP1,Casp12,CASP3,Ccl2,CCND1,CCR1,CCR5,CD226,CD44,CD74,CD83,CD86,CDH1,CDKN1A,CEBPD,CIITA,CLEC12A,CNNM2,COL1A1,CP,CREM,CSF1,CST7,CXCL10,CXCL12,CXCR4,CYTH1,CYTIP,DCN,DLL1,DUSP1,DYNLL1,EGR1,EGR2,ENPP3,ENTPD1,ETS1,F2R,F2RL1,FBXO31,FGF2,FMOD,FN1,Fnbp1l,FOXO1,FOXP3,FSCN1,GBP5,GCA,GCNT1,GFAP,H2-T24,HAS2,HCAR2,HDC,HEG1,HIF1A,HIVEP3,HLA-A,HLA-DQA1,ICAM1,IER3,IGF1,IGFBP4,IGFBP5,IGFBP7,IL15RA,IL16,IL17A,IL1R1,IL1RN,IL2RA,IL2RG,IL4I1,IRF1,IRF4,ITGA5,JAK3,KIT,KLF4,KLF5,LAD1,LIPG,LOX,MITF,MMP14,MMP19,MMP2,MR1,MRC1,MYOZ1,NEDD9,NFIL3,NFKBIA,NR4A1,NR4A2,NR5A2,NRP1,OSBPL3,PDE4A,PENK,PIK3CG,PKN1,PLA2G4A,PLEKHA4,PLK2,PPARG,PRDM1,PROM1,PTGES,PTGS2,PYCARD,RASGEF1B,RGS2,RUNX2,SAP30,SNAI1,SNAI2,SOCS3,SPHK1,SPP1,ST3GAL1,STAR,TGFA,TGFB1,THBD,THBS1,THEMIS2,TNFAIP6,TNFRSF11B,TRAM1,TWIST1,UHRF1,VEGFC,VIM,ZC3H12C | 1326 (14) |
| 15-epi-lipoxin A4 | NA | chemical - endogenous mammalian | NA | -3.00e-02 | NA | 0.0e+00 | ALOX12,ALOX15,C5AR1,IRF5,PDPN,SIGIRR,STAT1,THY1,TLR4 | 927 (10) |
| EGLN1 | 7.80e-01 | enzyme | NA | -3.00e-02 | NA | 1.0e-02 | ADAMTS5,ANGPT2,Ccl2,CD86,COL2A1,CXCR4,DLL1,EDN1,HIF1A,ICAM1,IL1RL2,INHBA,JAG1,PGK1,PTGS2,SDC4,SLC2A1,TGFB1,TNFRSF11B,VCAM1 | 1374 (21) |
| UCHL1 | -1.04e+00 | peptidase | NA | -3.00e-02 | NA | 0.0e+00 | BCL2L1,CDKN1A,DOCK10,DPYSL2,GABARAPL1,GOLM1,HDAC9,HERC6,HOXD9,LBH,LDHB,LPIN1,PDP2,PHF20,PI4K2B,PIK3CG,PLA2G4A,PSMB5,RHOF,SERPINE1,SH2D4A,SH3D19,SLC39A8,SMPDL3B,SNCA,UBA7,ZC4H2 | NA |
| mevalonic acid | NA | chemical - endogenous mammalian | NA | -4.00e-02 | NA | 5.0e-02 | ABCA1,GNAI1,ICAM1,LPL,MYOCD,PLAT,PTGS2,SERPINE1,SREBF1,TGFB1,VCAM1 | NA |
| apicidin | NA | chemical - endogenous non-mammalian | NA | -5.00e-02 | NA | 1.0e-02 | AMPD3,CCR1,CCR3,CDKN1A,H6PD,ITGB7,PRKCD,PTGES,SLC35D1 | 1243 (19) |
| HOXA4 | -1.40e-01 | transcription regulator | NA | -5.00e-02 | NA | 2.0e-02 | ACTA2,ANKRD1,CCND1,CCND2,TAGLN,TAGLN2 | NA |
| NFIX | NA | transcription regulator | NA | -5.00e-02 | NA | 0.0e+00 | CCND1,CHI3L1,CKM,CLEC3B,CXCL14,ENO3,GFAP,HGF,NFATC4,SERPINE1,TNFSF18 | 854 (7) |
| AZD8055 | NA | chemical drug | NA | -5.00e-02 | NA | 0.0e+00 | BCL2L1,BCL2L11,CCND2,CDH1,CXCL10,FOXO1,FOXO3,SNAI1,STAR | 1484 (22) |
| maraviroc | NA | chemical drug | NA | -5.00e-02 | NA | 0.0e+00 | ACTN2,Ccl2,COL1A1,CXCL10,MYH6,TNNT2 | 717 (7) |
| anisomycin | NA | chemical - endogenous non-mammalian | NA | -5.00e-02 | NA | 0.0e+00 | AHR,ATF3,BCL2L1,CCND1,CDKN1A,CYBB,DUSP1,EGR1,HIF1A,IL1RL1,IRF1,IRS1,NR4A1,NTRK2,OCLN,RGS7,SDC1,SERPINE1,SIGIRR,SPP1 | 1395 (24) |
| bicuculline | NA | chemical - endogenous non-mammalian | NA | -6.00e-02 | NA | 0.0e+00 | ACTA2,ATF3,BDNF,BTG2,DUSP1,DUSP6,EGR1,EGR2,FBXO33,GADD45B,GADD45G,GRIA2,KLF4,MAFF,NR4A1,NR4A2,PFKFB3,PKM,PTGS2,SIAH2,TIPARP,ZDHHC9 | 1496 (22) |
| MYRF | -1.25e+00 | transcription regulator | NA | -6.00e-02 | NA | 2.0e-02 | ARHGEF25,BCL2L11,CEACAM1,CFI,CIZ1,COL14A1,KLHL21,LOXL4,MAG,MOG,NGEF,OTUD1,PDK4,PLP1,PRDM1,SERF1A/SERF1B,SOWAHC,TRAF5,UAP1L1 | NA |
| Histone h3 | NA | group | NA | -6.00e-02 | NA | 0.0e+00 | ACKR3,ACTA1,ADAM10,ADD3,ADGRA2,ADIPOQ,AKAP12,ANK1,AP1S3,ARHGEF5,ARSG,ATF3,B2M,BCL2L11,BDNF,BMP4,BTG3,CA9,CACNA1G,CAV1,Ccl2,CCNA2,CCND1,CCND2,CCR3,CD1D,CD9,CDH1,CDK14,CDKN1A,CDKN2C,CEACAM1,CIITA,CKAP4,COL4A6,CSF1R,CSPG4,CXCL10,DAB2IP,DIO1,DUSP10,EGR1,ENO3,EZH2,FGFR1,FKBP5,G6PD,GAD1,GAPDH,GAS2,GATA4,GLI1,GRIA2,HBA1/HBA2,HIVEP3,HOMER1,HOXA5,HOXB5,HPSE,ICAM1,ID2,IFITM3,IGF1,IGFBP4,IL17A,IL2RA,INHA,IRF4,ITGA5,KAT5,KDR,L1CAM,LRAT,MAD1L1,MAF,MAGED2,MET,MITF,MPZ,MRPS9,Mt1,MX1,NCF1,NDUFA7,NDUFAF2,NDUFC1,NDUFC2,NDUFV1,NFKBIA,NKD1,NRARP,PALLD,PAX3,PCDHA4,PDGFB,PER1,PIK3R1,PITX2,PPARG,PPP2R2B,PRDM1,PROS1,PTCH1,PTGES,PTGS2,RAB38,RARA,RBL1,RELN,RETN,RGS10,RGS4,RSAD2,RSPO1,RUNX1T1,RUNX2,SCN1A,SELE,SFRP1,SFTPB,SGK1,SLC7A6,SNAI1,SOCS3,SPHK1,SPP1,SREBF1,STAR,TACC2,TAGLN,TBX3,TBX5,TGFB1,TLR2,TMPRSS2,TOP2A,TRIB1,TSHZ3,TYRO3,UBC,USP18,VCAM1,WLS,ZNF420 | 1370 (19) |
| DNAJB4 | -9.20e-01 | other | NA | -6.00e-02 | NA | 0.0e+00 | CCND1,CDH1,CDKN1A,STAT1 | 1393 (22) |
| NR5A2 | -1.68e+00 | ligand-dependent nuclear receptor | NA | -6.00e-02 | NA | 1.0e-02 | ABCC3,ACTA2,Akr1b7,ANXA2,C3,C3AR1,C5AR1,Ccl7,CCND1,CDKN1A,CEBPD,CRP,CXCL10,CXCL16,CYP27A1,CYP7B1,GADD45G,GATM,GPT2,ICAM1,IL1RN,INHA,Mt1,NR0B2,NR4A1,NR5A2,PLK3,POLE4,RBPJL,RGS4,STAR,TGFB1,TNFRSF1B | 1314 (21) |
| CEMIP | -8.50e-01 | enzyme | NA | -7.00e-02 | NA | 0.0e+00 | AXIN2,CDH1,CDH2,PTP4A3,SLC1A5,SLC38A2 | 1084 (7) |
| INS | NA | other | NA | -7.00e-02 | NA | 0.0e+00 | ACADL,ACTA2,ADAM10,ADIPOQ,ANO1,BCL2L1,Ccl2,CCND1,CD36,CDH1,CDKN1A,CITED2,COL2A1,COX4I1,CRP,DEPTOR,DUSP1,EDN1,EGR1,EGR2,EIF4EBP1,ERBB3,ERRFI1,F3,FADS3,FOXO1,GABARAPL1,HGF,HIF1A,ICAM1,IER3,IGF1,IGFBP4,IGFBP5,IRS1,IRS2,JUND,LPL,mir-133,NDUFV1,NFE2L2,NOS1,NOX4,NR4A1,OGT,PLK2,PPARG,PRDM16,PTGS2,RASL12,RDH10,SELP,SLC1A3,SLC2A1,SNAI1,SNCA,SREBF1,TGFB1,UGCG | 1524 (19) |
| romidepsin | NA | biologic drug | NA | -7.00e-02 | NA | 3.0e-02 | BCL2A1,BCL2L1,BCL2L11,CCND1,CD86,CDKN1A,CXADR,CXCL10,DUSP1,DUSP6,EGR1,EZH2,FGF2,GADD45G,HIF1A,ICAM1,KAT5,MED26,PRDM1,PTGS2,RHOA,TNFAIP6 | NA |
| AURK | NA | group | NA | -8.00e-02 | bias | 0.0e+00 | ACER2,AEN,ANK1,BTG2,CDKN1A,CYP26B1,EDA2R,GAL3ST4,GOLGA4,PHLDB3,PRAG1,PSTPIP2,RRAD,SESN1,SULF2,TCEA3,TNFRSF10A,VWCE | NA |
| MAP3K14 | -8.00e-01 | kinase | NA | -8.00e-02 | NA | 1.0e-02 | ACTA2,ADGRE1,BCL2L1,BIRC3,CASP3,Ccl2,CD44,GADD45A,GBP5,ICAM1,IKBKB,NFKBIA,PDE3B,PLA2G4A,PON2,PTGS2,REL,RIPK3,SIX1,SIX2,SREBF1,TNFAIP6,VCAM1 | 677 (12) |
| AZGP1 | NA | transporter | NA | -8.00e-02 | NA | 0.0e+00 | BCL2L1,BMP4,CCND1,CDH1,EGR1,FBXO32,ITGA5,KRT19,PNPLA2,TRIM63,UCP3,VIM | 1135 (21) |
| LYL1 | 2.00e-02 | transcription regulator | NA | -8.00e-02 | NA | 0.0e+00 | ANGPT2,BCL2L1,BTG2,EGR1,ID4,ITGA2,RCBTB2,SCN1B,TAL1,TSPAN18 | 206 (4) |
| PTP4A3 | 1.50e+00 | phosphatase | NA | -8.00e-02 | NA | 0.0e+00 | CDH1,CDH2,CSK,FN1,HSP90AA1,ITGB3,SNAI1,STMN1,TERF2IP | 989 (17) |
| PTEN | -4.50e-01 | phosphatase | NA | -9.00e-02 | NA | 0.0e+00 | ABCA9,ABCC4,ABTB1,ACO2,ACSL1,ADAMTS9,ADIPOQ,ALDH1A3,ALG3,ANGPT2,ANXA1,ARG1,ATF3,BACE2,BCL2L11,BCL3,BMP1,BPGM,BTG1,BTG2,BTRC,C3,CA12,CA3,CALCRL,Ccl2,CCND1,CD44,CD86,CDH1,CDH2,CDK6,CDKN1A,CELSR1,CELSR3,CITED2,CLDN1,CNN3,CNNM4,COL14A1,COL16A1,COL18A1,COL1A1,COL27A1,COL3A1,COL5A1,COL5A2,COL8A1,CPEB3,CSRP1,CX3CR1,CXCL10,CXCL13,CXCR4,CYP27A1,CYSLTR1,DAAM1,DHCR7,DKK3,DMP1,DRAP1,DTX1,DUSP1,EBP,EDN1,EGF,EGR2,EIF4EBP1,ERBB3,ERRFI1,Esrra,ETS1,EZH2,F3,FAP,FGF1,FGF10,FGF9,FGFR1,FN1,FOXO1,FOXO3,FZD6,G0S2,GAPDH,GJA5,GNG2,GPM6A,GPR157,GPR160,GPR176,GPRC5C,GPX3,GSR,HCLS1,HGF,HIF1A,HMGN1,HSPA1A/HSPA1B,ID4,IDH3A,IDH3G,IFT27,IGF1,IGFBP5,IGFBP6,IL17A,IRS2,ISG15,ITGA8,ITGB3,JAG1,JUND,Kctd12b,KDR,KIT,KLF5,KLF6,KRT19,L1CAM,LAD1,LAMA3,LAMP2,LDHB,LGR5,LIMS1,LOXL1,LOXL2,LOXL4,LRAT,LSS,MAL,MAN1C1,MAPK14,MAT2A,MDH1,MEOX1,MET,MKI67,MME,MMP14,MMP15,MMP2,MPP7,MRC1,MVD,Naip1 (includes others),NCAM1,NDN,NDUFB3,NDUFC1,NEU1,NFE2L2,NFIL3,NHP2,NOP2,NOTCH4,NR2F2,NR4A2,NR5A2,NTS,OGT,PECR,PFKFB3,PGK1,PGM1,PHGDH,PIK3R1,PITX3,PKM,PLK1,PPARG,PPM1A,PPP2R2B,PRDM1,PREX1,PRKAA2,PRKCB,PTGS2,PTN,PTP4A2,PTPRC,PTPRF,PYGL,RAB30,RAB38,RNASEH1,RPS6KB1,RUNX1,SCTR,SDC1,SDC4,SEC23A,SELENOP,SERPINE1,SFRP1,SFTPB,SKP2,SLC20A1,SLC25A45,SLC26A7,SLC35D1,SLC46A3,SLC7A8,SLCO2B1,SMAD6,SMOX,SNAI1,SNAI2,SNX3,SOAT1,SOCS3,SORD,SOX8,SPARC,SPP1,SREBF1,SRSF1,STARD8,STAT5B,STEAP1,SULF2,SYK,SYNJ1,TAF10,TGFA,TGFB1,THBS1,TLE2,TNFRSF11B,TP53BP2,TRADD,TRAM1,TWIST1,TWIST2,UBA7,UNC93B1,VAV3,VCAM1,VEGFC,VIM,WNT4,YIPF4,ZBTB16,ZEB2 | 1648 (20) |
| PPARGC1B | -1.04e+00 | transcription regulator | NA | -9.00e-02 | NA | 1.0e-02 | ABCA1,ACADL,C3,CCND1,COX4I1,Cox8b,ESRRG,FBXO32,GPAM,LSS,MICOS10,MITF,MVD,MVK,MYH6,NDUFV2,PDK4,PPARGC1B,RUNX2,TRIM63 | NA |
| CDC73 | -3.10e-01 | other | NA | -9.00e-02 | NA | 2.0e-02 | CCND1,CDH1,IGF1,IGFBP4,IRF1,PTGES,RUNX1,SOCS1,STAT1 | NA |
| PKNOX2 | 3.20e-01 | transcription regulator | NA | -9.00e-02 | NA | 0.0e+00 | BTG2,CDH1,CDKN1A,COL2A1,EGR1,GADD45A,IGFBP5,SNAI2,STAT1,VIM | NA |
| LINC01612 | NA | other | NA | -9.00e-02 | NA | 3.0e-02 | ATF3,CASP3,CDKN1A,SNAI1 | NA |
| NVP-TAE684 | NA | chemical drug | NA | -9.00e-02 | NA | 0.0e+00 | BCL2L11,CCND1,CCND2,CDH1,COL3A1,COL5A2,ERBB3,ESRP2,ETV5,MITF,OCLN,RET,SERPINE1,SNAI1,SPARC,TNFRSF8,VCAN,VIM | 1360 (20) |
| NR4A1 | 1.72e+00 | ligand-dependent nuclear receptor | NA | -1.00e-01 | NA | 0.0e+00 | ACO2,ACTA1,ACTA2,ADIPOQ,ALDOA,APOD,ATF3,AXIN2,BCL2L11,BPGM,Ccl2,CCND1,CCND2,CD36,COL16A1,COL1A1,COX6B1,CSF1,CST7,CXCL12,DAPK1,ELK3,ENO2,ENO3,FBP2,FN1,FOXP3,G0S2,G6PD,GBE1,GPD1,GPI,GREM1,GSK3A,HCAR1,HDC,HIF1A,ICAM1,IDH3A,IKZF2,IL16,IL17A,IL2RA,ITGAE,ITGB4,KCNIP3,KITLG,LPIN1,LPL,MAFA,MARCKSL1,MAT2A,MDH1,MPZ,Mt1,MYCN,MYOD1,NDUFA1,NDUFA7,NDUFB3,NDUFS7,NFKBIA,NR4A1,NR4A2,NR4A3,OCLN,PC,PDK4,PEBP1,PGAM2,PGK1,PGM1,PHKA1,PHKB,PHKG1,PPARG,PPP1R3C,PRKAG3,PRPS2,PYGM,RASSF4,RXRA,SERPINE1,SLC37A2,SMAD7,SOAT1,SREBF1,STAR,STARD10,TAGLN2,UCP3,VCAM1 | 1509 (21) |
| SB 290157 | NA | chemical reagent | NA | -1.00e-01 | NA | 0.0e+00 | ADGRE1,BMP1,BMP4,C3AR1,CD86,CDH1,PTGS2,SPP1,TAGLN,THBD,THBS1 | 1260 (16) |
| CDH11 | -1.54e+00 | other | NA | -1.00e-01 | bias | 2.0e-02 | ADI1,CD9,EGF,IGF1,ITGB2,MMP15,PIK3R1,PRKCD,TNK2,VEGFD | NA |
| PD 123319 | NA | chemical drug | NA | -1.00e-01 | NA | 0.0e+00 | ANGPT2,Ccl2,COL1A1,CX3CR1,CYBA,KDR,MYH3,MYOG,NCF2,NOX1,PTGS2,RET,SERPINE1,SPP1,TGFB1,TIMP1,WNT11 | 1484 (23) |
| ASAH1 | -5.00e-01 | enzyme | NA | -1.00e-01 | NA | 0.0e+00 | ACER3,CERS6,COL2A1,ELOVL7,ETS1,FGF2,ITGA5,MC2R,NR4A1,NR4A2,NR4A3,RUNX2,SPHK1,STAR,TAGLN,TGFB1 | 941 (14) |
| Igm | NA | complex | NA | -1.00e-01 | NA | 0.0e+00 | BCL2A1,BCL2L1,BCL2L11,CCNA2,CCND2,CD22,CD44,CDKN1A,CX3CL1,EGR1,FCGR2B,GPSM1,IL17A,IL2RA,IRF4,PRDM1,PTAFR,SAMSN1,TRAF5,UGCG,WNT16,ZFP36L1 | 1368 (22) |
| SOX2-OT | NA | other | NA | -1.10e-01 | NA | 1.0e-02 | ALDH1A1,CD44,CDH1,CDH2,PROM1,VIM | NA |
| dehydroisoandrosterone | NA | chemical - endogenous mammalian | NA | -1.10e-01 | NA | 2.0e-02 | B2M,BMP4,Ccl2,CCND1,CHRNA4,ECM1,EDIL3,FKBP5,GFAP,ICAM1,IGF1,IL17A,KCNA5,MYH6,MYH7,NFKBIA,PPARG,SELE,SLC27A1,STEAP2,TMPRSS2,VCAM1 | NA |
| capsaicin | NA | chemical drug | NA | -1.10e-01 | NA | 0.0e+00 | ABCC3,BCL2L1,BDNF,CAMK2A,CASP3,CCND1,HGF,IGF1,KITLG,MMP14,MMP2,PPARD,PPARG,PTGS2,RHOA,RXRA,SGK1,TNFRSF11B,TRPV1,TRPV4,WNK1 | 1298 (18) |
| tunicamycin | NA | chemical - endogenous non-mammalian | NA | -1.10e-01 | NA | 0.0e+00 | ACTA2,ADAM10,ARFGAP1,ARFGAP3,ARHGEF2,ASNS,ATF3,ATP2A2,AXL,BIRC3,BLOC1S1,Casp12,Ccl2,CCND1,CD36,CDH1,CDKN1A,CEBPD,CHAC1,COL2A1,DDIT4,EDEM1,EGR1,EIF4EBP1,ERBB3,ERO1B,ETS1,FKBP11,FN1,GADD45A,GADD45B,GOLGA4,GORASP2,GP1BB,GPT2,HERPUD1,HOOK1,HPSE,ICAM1,KDELR2,KLF4,LGR5,LMAN2,LPIN1,MVD,NAPA,NEDD4L,NFIL3,NFKBIA,PDRG1,PHLDA1,PPARG,PROM1,PTGS2,S100A4,SDC1,SEC24D,SKP2,SLC20A1,SLC25A28,SLC2A1,SLC7A1,SOCS3,SREBF1,SRP68,STAR,TGFA,TLR2,TMED3,TMEM67,TNFRSF10A,TPO,TRPC6,UFM1,VCAM1 | 1470 (22) |
| ferulic acid | NA | chemical - endogenous non-mammalian | NA | -1.10e-01 | NA | 2.0e-02 | CASP3,CD34,CDKN1A,DPYSL2,GFAP,MKI67,PTPA,PVALB,TIMP1,TLR4 | NA |
| ZBTB7B | 9.00e-01 | transcription regulator | NA | -1.10e-01 | NA | 0.0e+00 | ACADL,ACSM3,AHR,COL1A1,COL2A1,DHRS9,ECH1,HSD17B12,IL17A,IL17RE,IL1R1,IL2RA,IL2RB,ITGAE,KLF4,MAF,NDUFAB1,NDUFV2,NRP1,PAQR9,PDP2,SFXN5,TNFRSF4,TYSND1 | NA |
| MGAT3 | -1.13e+00 | enzyme | NA | -1.10e-01 | NA | 0.0e+00 | CDH1,CDH2,ITGA2,ITGA3,ITGA5,PROM1,SNAI1 | 1452 (19) |
| Nos | NA | group | NA | -1.20e-01 | NA | 4.0e-02 | BDNF,CDH1,EGR1,GCH1,OLR1,TIMP1 | NA |
| MBD3 | 8.20e-01 | other | NA | -1.20e-01 | NA | 0.0e+00 | ACTC1,BCAT2,BTRC,CCND1,CCND2,CD44,DAAM1,DIXDC1,DPP4,DVL1,EFNA5,FBXW4,FZD1,FZD4,FZD5,LGR5,LMO2,Mt1,MYH6,NKD1,PITX2,POLE4,PPARD,PTPN4,SFRP1,SFRP2,TAL1,WNT16,WNT2B,WNT5A,WNT6 | 1429 (19) |
| BDKRB2 | -7.50e-01 | G-protein coupled receptor | NA | -1.20e-01 | NA | 1.0e-02 | CD44,EDN1,FOXO1,ICAM1,PTGS2,SNCA,TGFB1 | 1462 (20) |
| TCF4 | 4.00e-02 | transcription regulator | NA | -1.20e-01 | NA | 0.0e+00 | ADAM17,ADAMTS9,AEN,ALCAM,ARHGAP4,B4GALT1,BARD1,BCL6,BHLHE40,BYSL,CASP1,CASP3,CASP8,CBFA2T3,CCL21,CCNA2,CD9,CDC25B,CDK6,CDKN1A,CKAP4,CREB1,CREM,CSF3R,CSRNP1,CTSE,DACH1,DNAJC12,DPF2,DUS3L,E2F8,EDEM1,ELF1,ELF4,ENTPD1,ESCO2,EXOSC1,EXOSC7,EYA1,FAM111A,FGD2,FKBP11,FKBP7,FOXO1,FRMD3,GIMAP4,HIF1A,Hmgn2 (includes others),HTR2B,ID2,IFI16,IGFBP4,IGFBP5,IL16,IL4I1,IL7,IMP4,INHBA,ITGA3,ITGB3,JAG1,LAMA4,LMO2,MITF,MKI67,MPV17L,MYF5,NCAPG,NEDD9,NEIL1,NOTCH2,OPTN,PDIA4,PIK3C2B,PIK3CG,PLK2,PLPP5,PRC1,PRDM1,PRDX4,PTGS2,RASGRP2,RCBTB2,RPS6KB1,RUNX2,SACS,SDC2,SEC24D,SELENOP,SERPINF1,SLC12A7,SMAD6,SMAD7,SNAI2,SOCS3,SORBS2,SPC25,SURF6,TRADD,TRAF5,UBE3A,VASH2,VSIR,WLS,ZDHHC17,ZEB2 | 966 (12) |
| raloxifene | NA | chemical drug | NA | -1.20e-01 | NA | 0.0e+00 | ACVRL1,BCAS1,BCL3,BMP4,CALCR,CBX6,CCND1,CDKN1A,CLK1,CSF1,CTSH,CXCL12,CYP1B1,DBN1,DDIT4,DUSP1,DYNLL1,ECH1,EDN3,EGR3,ENG,ERBB3,F2R,H2AC18/H2AC19,HSPA1A/HSPA1B,IER3,IGF1,IGFBP4,IL1R1,INHBB,INPP5J,IRF6,ITGB3,KLF6,L1CAM,LITAF,LUM,MAPK14,MATN2,MB,MFAP5,MKI67,MMP2,MYBL1,PDGFRA,PLK2,PLK3,PPP1R3C,PTGER3,PTGS2,PVALB,PXDN,RAB2A,RAP1GAP,RHOA,ROCK1,SELENBP1,SERPINE1,SIAH2,SMAD7,SOCS1,SPP1,TGFA,THBD,TIMP1,TM4SF1,TNFRSF11B,TOP2A,TTC9 | 1695 (21) |
| PDE3A | -2.50e-01 | enzyme | NA | -1.20e-01 | NA | 2.0e-02 | CCND1,CDKN1A,CREM,DUSP1 | NA |
| EBF1 | -1.14e+00 | transcription regulator | NA | -1.30e-01 | NA | 0.0e+00 | ADIPOQ,BCL6,C8orf44-SGK3/SGK3,CBLC,CCL24,CD244,CD28,COL1A1,CXCL10,CXCL12,EBF1,EIF4EBP1,FBP2,FOXO1,IKBKB,INPP5D,IRF1,IRS1,LEF1,NFIL3,PDE3B,PHKA1,PHKG1,PIK3R1,PIK3R3,PPARG,PPP1R3C,PRDM1,PRKAA1,PRKAA2,PRKAG3,PRKAR2B,PTPRF,RASGRF2,RPS6KB1,SFRP2,SHC4,SOCS1,SOCS3,SREBF1,STAT1,Tcf7,TLR2,TLR4,UCP3 | 1332 (24) |
| CRKL | NA | kinase | NA | -1.30e-01 | bias | 3.0e-02 | CXCL10,FGL2,HDC,IL15RA,PLA1A,RILPL1 | NA |
| MGLL | -1.70e-01 | enzyme | NA | -1.30e-01 | NA | 5.0e-02 | ADGRE1,ADIPOQ,Ccl2,CD36,PNPLA2,PPARG,SREBF1 | NA |
| bardoxolone | NA | chemical drug | NA | -1.30e-01 | NA | 2.0e-02 | ACTA2,BCL2L1,CCND1,CDKN1A,EPHX1,GCLC,GSR,HERPUD1,IRS1,NFKBIA,UGDH | NA |
| SLC1A5 | -1.58e+00 | transporter | NA | -1.30e-01 | NA | 0.0e+00 | CDH1,SLC38A1,SNAI1,VIM | NA |
| LAMP2 | -8.60e-01 | enzyme | NA | -1.30e-01 | NA | 0.0e+00 | COX6B1,CTSC,FN1,HIF1A,ITGA3,ITGA6,ITGB3,ITGB4,MRPL38,MRPS23,MX1,STAT1 | 1164 (16) |
| ZNRF3 | NA | enzyme | NA | -1.30e-01 | NA | 1.0e-02 | AXIN2,GLUL,LEF1,WNT4 | 1083 (7) |
| BCAR4 | NA | other | NA | -1.30e-01 | NA | 2.0e-02 | CDH1,CDH2,PFKFB3,VIM | NA |
| dalfampridine | NA | chemical drug | NA | -1.40e-01 | NA | 0.0e+00 | ATF3,BTG2,DUSP1,DUSP6,EGR1,EGR2,FBXO33,GADD45B,GADD45G,GRIA2,KCNA5,KLF4,MAFF,NR4A1,NR4A2,PFKFB3,PKM,PTGS2,SIAH2,TIPARP | 1123 (17) |
| IGFBP3 | -1.90e-01 | other | NA | -1.40e-01 | NA | 0.0e+00 | ADIPOQ,BCL2L1,CDKN1A,COL2A1,ICAM1,IGF1,MMP2,RETN,SDC2,SERPINE1,STAT1,THBS2,TNC,VCAM1 | 1463 (17) |
| BRD7 | NA | transcription regulator | NA | -1.40e-01 | NA | 1.0e-02 | CDH1,CDKN1A,FGF2,FN1,FOXP3,PYCARD,SERPINE1,VCAN,VIM | NA |
| TGFBR3 | -1.00e-01 | kinase | NA | -1.40e-01 | NA | 0.0e+00 | ALDH1A1,CDH1,COL4A6,FN1,FOXP3,SERPINE1,SNAI1,SNAI2,TWIST1 | 914 (16) |
| CHKB | 2.00e-01 | kinase | NA | -1.40e-01 | bias | 0.0e+00 | ACADL,ACSL1,ACSL3,CHKA,CREB1,ECH1,FABP1,GJA5,HCN4,ICAM1,NPR1,PPARD,PPARGC1B,RXRA,RXRG,SMARCD3 | NA |
| DAXX | -4.00e-02 | transcription regulator | NA | -1.50e-01 | NA | 1.0e-02 | CASP3,CASP8,CCND1,CDKN1A,FADD,IFIH1,IKBKE,IRF3,MAVS,SERPINE1,TRADD | NA |
| Calmodulin | NA | group | NA | -1.50e-01 | NA | 0.0e+00 | BDNF,Calm1 (includes others),CD44,CNTN2,DLG3,DOC2B,EPHB6,F3,KDR,KLF5,LRRTM3,MAP9,NOS1,NPAS2,OPCML,RAB40B,RIMBP2,TIAM2,TSPAN2 | 1041 (18) |
| ceftriaxone | NA | chemical drug | NA | -1.50e-01 | NA | 0.0e+00 | AQP4,GFAP,SLC1A1,SLC1A3 | NA |
| CSNK1A1 | -9.00e-02 | kinase | NA | -1.50e-01 | NA | 1.0e-02 | AXIN2,CCND1,CDKN1A,CXCR4,HNRNPC | 1424 (22) |
| PURA | 2.10e-01 | transcription regulator | NA | -1.50e-01 | NA | 1.0e-02 | ACTA2,CASP8,CDKN1A,GFAP,ITGAD,ITGAL,SPN | NA |
| CHS-828 | NA | chemical drug | NA | -1.50e-01 | NA | 3.0e-02 | ALDH1A1,CD44,LGR5,PROM1 | NA |
| GRB10 | -7.00e-02 | other | NA | -1.50e-01 | NA | 4.0e-02 | IGF1,IRS1,KDR,KIT,MRC1 | NA |
| SW016789 | NA | chemical reagent | NA | -1.50e-01 | bias | 5.0e-02 | ATF3,DUSP1,NR4A1,NR4A3 | NA |
| PDYN | -9.00e-02 | transporter | NA | -1.50e-01 | NA | 5.0e-02 | HOMER1,KDR,NRP1,PLXND1 | NA |
| withaferin A | NA | chemical reagent | NA | -1.50e-01 | NA | 0.0e+00 | BCL2L11,CDKN1A,PTGS2,RUNX1,RUNX2,SERPINE1,SKP2,SPP1,VIM | 1393 (18) |
| IL2RG | -1.02e+00 | transmembrane receptor | NA | -1.60e-01 | NA | 3.0e-02 | ABCG1,ARHGAP45,ARMCX2,BCL6,CXCL10,CXXC5,ETS1,FOXP3,HLA-A,IKBKE,IL17A,IRF3,ISG15,NEDD4L,SESN1,STAT1,UBA7 | NA |
| PCGEM1 | NA | other | NA | -1.60e-01 | NA | 4.0e-02 | ALDOA,G6PD,GAPDH,GPI,GSR,IDH1,LSS,PDK4,PGAM2,PGK1,PKM,SLC2A1 | NA |
| IRF6 | -2.05e+00 | transcription regulator | NA | -1.60e-01 | NA | 0.0e+00 | ADAMTS5,ARG1,CBFA2T3,CD86,CD9,CDH2,GLI2,IL17A,KLF4,MAD1L1,MRC1,NLRP3,NR4A2,PLA2G2D,PPARG,PPARGC1B,PTGES,PTGS2,SOCS1,TLR4 | 840 (16) |
| FOXQ1 | NA | transcription regulator | NA | -1.60e-01 | NA | 1.0e-02 | CDH1,DACH1,FN1,VIM | 833 (7) |
| SRSF1 | -7.80e-01 | other | NA | -1.60e-01 | NA | 1.0e-02 | CD200,CDH1,COL1A1,DIO1,ENG,FN1,HNRNPL,KLF6,PLK1,SRSF1,VIM | NA |
| FOSB | 1.10e-01 | transcription regulator | NA | -1.60e-01 | NA | 3.0e-02 | BDNF,CCND1,F3,FOLR2,GRIA2,INHBA,MMP2,PPARG,RUNX2,SERPINE1,TIMP1 | NA |
| HDL-cholesterol | NA | complex | NA | -1.60e-01 | NA | 2.0e-02 | ALDH1L2,CHAC1,CREM,DDR2,DEPTOR,DHCR7,DUSP15,EGR1,EIF4EBP1,GPT2,MSMO1,RASGRP1 | NA |
| XIAP | 9.00e-02 | enzyme | NA | -1.60e-01 | NA | 3.0e-02 | CASP3,CCND1,CDH2,CDK6,CDKN1A,CSF1,PTGS2,SELE,SERPINE1 | NA |
| pimagedine | NA | chemical drug | NA | -1.70e-01 | NA | 0.0e+00 | ACTA2,BCL2L1,CASP1,CASP3,CAV1,CNN1,CRP,GADD45B,ICAM1,NOS1,POU2F2,SERPINE1,SLC22A3,TAGLN,TGFB1 | 1383 (18) |
| SNCA | -1.83e+00 | enzyme | NA | -1.70e-01 | NA | 0.0e+00 | ADGRE5,AIF1,ALDH1A1,ANKRD55,ARFGAP3,ARG1,ARHGEF28,ASIC2,B2M,BAIAP2,BCL11B,BCL2L1,BDNF,BHLHE22,BHLHE40,CA12,CACNA1D,CARMIL1,CASP3,CCBE1,CCDC80,Ccl2,CD22,CD44,CD74,CDC42EP3,CDH6,CFL1,CHAC1,CHL1,CHMP4B,CHRNA4,CIITA,COBL,CRYM,CTHRC1,CXCR4,CYBA,CYBB,DGKG,DLK1,DNAJC12,DNM1,DOC2B,DUSP1,EGF,EMP1,ENO2,EZR,FAM107A,FAM20C,FBXO32,GADD45A,GBP2,GBP5,GCLC,GDA,GFAP,GLO1,GRAMD1B,GRIN2D,GRIP2,HIF1A,HLA-DQA1,HLA-DRA,HMCN2,HOMER2,Ifgga2l1/RGD1309362,Ifi47,IGF1,IL17RA,IL2RA,IRF1,ISG15,KCNF1,KCNJ11,KIF1A,KIF4A,KLF10,KLF4,LAMP2,LDHB,LHFPL2,MAP1B,MAP1LC3A,MAP1LC3B,MARK1,METRNL,MICAL1,MX1,NCF1,NCF2,NCF4,NLRP3,NPTXR,NR4A2,NRP2,NTN1,PCDHA4,PDIA5,PDZRN3,PGK1,PITX3,PLK3,PLXNB3,PRKCD,PTGS2,PTPRB,RET,RGMA,RGS14,RPRML,RSAD2,S100A6,SCN7A,SERPINE1,SLC18A2,SLC27A1,SLC37A4,SLITRK1,SLITRK2,SMOC1,SNCA,SORCS1,SRPX2,SV2B,SYP,TC2N,TLR2,TLR4,TMBIM1,TMEM255A,TNFRSF19,TNFRSF4,TRIM47,VAT1L,WEE1,WIPF3 | 1402 (19) |
| FST | -3.00e-01 | other | NA | -1.70e-01 | NA | 1.0e-02 | ACSL1,ADIPOQ,CD36,COL2A1,FN1,GPAT3,INHBB,LHX8,MMP14,MMP2,MSTN,MYF5,PPARG,PPARGC1B,PRDM16,SCX,SMAD7,TWIST1,UCP3,ZBTB20,ZEB2 | NA |
| NC410 | NA | biologic drug | NA | -1.70e-01 | NA | 0.0e+00 | ATF3,BTG2,CCL24,Ccl6,CD36,CD74,CDKN1A,CXCL10,DUSP1,EDNRB,EGR1,F13A1,FANCA,FCGRT,FOLR2,GADD45B,GBP5,HERC6,HSPA1A/HSPA1B,IER3,IFIT1,IRF1,MMP14,MRC1,Mt1,PARP14,PLTP,RSAD2,RUNX2,SOCS1,STAT1,STAT6,TGFB1,TGFBI,TNFRSF25 | NA |
| Sox2ot | NA | other | NA | -1.70e-01 | NA | 0.0e+00 | ACTA2,ALDH1A1,CD44,CDH1,CDH2,MKI67,PROM1,TGFB1,VIM | 696 (7) |
| TCF7 | NA | transcription regulator | NA | -1.70e-01 | NA | 2.0e-02 | AXIN2,BCL11B,BCL6,CEBPD,IL17A,MET,MMP14,PPARD,PPARG,PRDM1,RARA,SDC2,SPP1,SRSF1,Tcf7 | NA |
| MDL 73811 | NA | chemical reagent | NA | -1.70e-01 | NA | 5.0e-02 | C3,CDKN1A,FN1,ITGB3,PLK1,SERPINE1,TYMS | NA |
| POM121/POM121C | 5.20e-01 | other | NA | -1.70e-01 | NA | 2.0e-02 | BCL6,FBXO33,NOL12,NTNG2,NUP210,SLC27A1,TMPRSS2,ZFP36,ZNF180 | NA |
| fluoxetine | NA | chemical drug | NA | -1.80e-01 | NA | 2.0e-02 | BCL2L1,BDNF,CASP3,EGR1,FABP1,FGF2,GNAI1,GNAS,GPATCH3,HTR2B,KCNA5,KCNK2,LSS,MITF,MMP2,NOS1,NTRK2,PDE4A,S100A10,ST8SIA4,TAGLN,TPH1 | NA |
| TGS1 | 1.20e-01 | enzyme | NA | -1.80e-01 | NA | 1.0e-02 | CCND1,CCND2,CDK2,CDK6,CDKN2C,CHAC1,EIF2AK3,HERPUD1,PREB,RASGRF1,SESN1,TMX4,UFM1 | 781 (7) |
| XDH | 3.10e-01 | enzyme | NA | -1.80e-01 | NA | 0.0e+00 | ABCA1,ABCG1,ACTA2,Ccl2,CCR5,CXCR4,CYBB,DUSP1,DUSP10,F3,HIF1A,IL2RA,MMP14,MMP2,PPARG,SERPINE1,SLC2A1,SPP1,VIM | 1054 (17) |
| quercetin | NA | chemical drug | NA | -1.80e-01 | NA | 0.0e+00 | ABCA1,AHRR,ANK2,BCL2L1,BDNF,BHLHE40,BIRC3,C3,Casp12,CASP3,CAV1,Ccl2,CD44,CDK5R1,CDKN1A,CRYL1,CXCL10,CYP1B1,DAPK1,DUSP5,ECH1,EDN1,EGF,EGLN1,EGR1,FCGBP,FZD1,FZD10,GAB1,GNAI3,HIF1A,HPSE,HSF2,ICAM1,IER3,IL17A,IRS2,ISG15,ITGAL,KCTD15,KLF10,KLF4,LEPR,LPL,MAP2,MKI67,MRGPRF,NEDD9,NFE2L2,NPAS2,PHGDH,PLD1,PON2,PRDX5,PTGS2,ROCK1,SELE,SMAD7,STAR,TLR7,TST,VCAM1,WNK1,WNT5A | 1272 (13) |
| NFATC3 | -6.20e-01 | transcription regulator | NA | -1.80e-01 | NA | 3.0e-02 | ACTA2,AIF1,ATF3,CASP3,COL1A1,CXCR5,DDIT4,EDN1,EGR2,EGR3,F3,GAP43,IL2RA,MYOCD,NR4A1,PPARG,PTGS2,SFTPB | NA |
| CL097 | NA | chemical reagent | NA | -1.80e-01 | NA | 4.0e-02 | AXL,BCL3,CD86,CXCL10,IRAK3,MICB,MX1 | NA |
| nocodazole | NA | chemical reagent | NA | -1.80e-01 | NA | 0.0e+00 | CAV1,CCND1,CDKN1A,CSK,CSNK1D,CSNK2B,DAPK3,FLNA,FYN,GSK3A,HIF1A,KHDRBS1,MAP2K2,MAP2K4,MAP4K1,MAPK3,MAPK4,PLK1,PPM1A,PPP5C,PRKCB,PRKCE,PRKCZ,PRKD1,PTGS2,PTPN12,PTPN6,RPS6KB1,STK3,UHRF1 | 1265 (16) |
| POMC | 4.60e-01 | other | NA | -1.80e-01 | NA | 4.0e-02 | Akr1b7,BCR,CXCR4,CYP1B1,DUSP1,FGF2,GAD1,GAPDH,GCLC,GZMB,ICAM1,MC2R,MITF,NOS1,NR4A1,NR4A2,NR4A3,NR5A1,PCSK5,SDC2,SELE,STAR,UCN,VCAM1 | NA |
| RGCC | 7.90e-01 | other | NA | -1.90e-01 | NA | 1.0e-02 | ACTA2,CDH1,CDH2,FN1,SNAI1,SNAI2,SREBF1 | 669 (7) |
| CCK | 3.70e-01 | other | NA | -1.90e-01 | NA | 3.0e-02 | CNR1,CREM,CXCL10,EGR1,GFAP,IL17A,MET,PENK | NA |
| cobalt chloride | NA | chemical reagent | NA | -1.90e-01 | NA | 0.0e+00 | ACTA2,ADAMTS1,ALDOA,ANPEP,BACH1,BDNF,BHLHE40,CA9,CDKN1A,COL18A1,CP,CXCR4,CYBRD1,CYP1B1,DDIT4,DUSP1,HIF1A,HIF3A,MITF,PFKFB3,PGK1,PKM,PROM1,PTGS2,SERPINF1,SLC1A1,SLC1A3,SLC2A1,SMAD6,SMAD7,SMAD9,SPHK1,TEK | 1406 (19) |
| MSB0011359C | NA | biologic drug | NA | -1.90e-01 | NA | 0.0e+00 | ATF3,BTG2,Ccl6,CDKN1A,CXCL10,DUSP1,EDNRB,EGR1,F13A1,FANCA,FCGRT,FOLR2,GADD45B,GBP5,HERC6,HSPA1A/HSPA1B,IER3,IFIT1,IRF1,MMP14,Mt1,PARP14,PLTP,RSAD2,RUNX2,SOCS1,TGFBI | NA |
| ShK-223 | NA | chemical reagent | NA | -1.90e-01 | NA | 1.0e-02 | C3AR1,CP,CSF3R,CSK,CX3CR1,DOCK2,FCGR1A,IKBKB,IL10RB,IL1RN,KDM2B,KDM3A,LAMP2,LSR,MYCT1,NCOR2,PIK3CG,PLCG2,PLD2,PTPN6,RGL1,RPL28,RPS10,RTN4RL1,SLCO2B1,SLFN13,TM4SF1 | NA |
| HNRNPU | -6.10e-01 | transporter | NA | -1.90e-01 | NA | 0.0e+00 | CYP26B1,DACH1,GAPDH,GPNMB,IFIH1,IGF1,INHA,INHBB,KITLG,MYOD1,NTRK2,Oasl2,OSR1,PDGFD,SOX8,SPP1,TGFB1,TYRO3,VCAM1,WNT2,WNT4 | 616 (9) |
| ZBTB48 | -1.30e-01 | transcription regulator | NA | -1.90e-01 | bias | 1.0e-02 | ACKR3,ARHGAP24,COL11A1,GPNMB,MMP15,MSS51,RNF150,ROS1,SNCA,SPP1,TMEM63C | NA |
| SIX4 | -1.38e+00 | transcription regulator | NA | -2.00e-01 | bias | 0.0e+00 | ALDOA,DEPTOR,MET,MYF5,MYOG | NA |
| Notch | NA | group | NA | -2.00e-01 | NA | 0.0e+00 | ABLIM1,ACTA2,ADGRE1,ANKRD1,CD300LF,CDH1,CDKN1A,CKAP4,CNN1,COLQ,CSF2RB,CSF3R,CXXC5,CYP4F2,DDX6,DTX1,DUSP1,FCGR2B,GADD45B,GATM,GFRA1,HEY2,HPSE,ID2,IDH1,INPP5J,JAG1,KCNK6,LTB4R,MET,MEX3B,mir-143,MMP2,NCF1,NET1,NFAM1,PROX1,PTPRF,RGCC,S100A11,SKAP2,SMAD6,ST8SIA4,TAGLN,TP63,TRPC6,ZEB2 | 1428 (18) |
| SCH 58261 | NA | chemical reagent | NA | -2.00e-01 | NA | 3.0e-02 | BDNF,COX4I1,EGR1,EGR2,IFITM3,LILRB3,NR4A1,PARK7,PTGS2,TPST1 | NA |
| TGFB1I1 | -1.27e+00 | transcription regulator | NA | -2.00e-01 | NA | 0.0e+00 | CD36,CDKN1A,FABP1,FN1,KLF4,KRT19,LTBP1,LTBP2,NOX4,SERPINE1,SMAD7 | 1429 (22) |
| HMGA2 | NA | enzyme | NA | -2.00e-01 | NA | 0.0e+00 | BCL2A1,CXCR4,HOXD9,ID2,IL2RA,KLF15,LPL,MIA,SNAI1,SNAI2,SPP1,SREBF1,TWIST1 | 995 (13) |
| BLACAT1 | NA | other | NA | -2.00e-01 | NA | 0.0e+00 | CCND1,CDH1,MKI67,RPS15A,VIM | 1083 (7) |
| Mir218 | NA | microRNA | NA | -2.00e-01 | NA | 1.0e-02 | CXCR4,LEF1,SFRP2,SPP1,Tcf7 | NA |
| ISG15 | -8.50e-01 | other | NA | -2.10e-01 | NA | 0.0e+00 | CLIC2,COL12A1,COL14A1,COL1A1,COL5A2,COL7A1,CTSS,CYP1B1,EIF4EBP1,GCLC,GPX7,HLA-A,IFIT1,IFITM3,ITGA11,LTBP1,LTBP2,MX1,PTGIS,TIMP1,USP18,VCAN | 1038 (14) |
| FOXO1 | 2.95e+00 | transcription regulator | NA | -2.10e-01 | NA | 0.0e+00 | A2M,ACSL5,ACTA2,ADIPOQ,ALOX5,ANGPT2,APLN,ATP6V0B,BANK1,BCL2A1,BCL2L11,BCL6,BIRC3,CASP8,CAV1,Ccl2,CCNA2,CCND1,CD36,CDC42EP3,CDKN1A,CDKN2C,CEBPD,CENPF,CERS4,CITED2,CNR1,COL1A1,COL2A1,CTSE,CTSK,CXCL10,CYP27A1,CYP7B1,DAPK1,DDIT4,DEPDC1,EBF1,EDN1,EDNRB,EFHD1,EGR1,EGR2,EIF4EBP1,ELOVL5,ELOVL7,ENPEP,FBXO32,FMOD,FN1,FOXC1,FOXO1,FOXP3,FYN,GAB1,GABARAPL1,GADD45A,GADD45B,GFPT2,GPAM,GPD1,GPD2,GPI,GPX3,GRHPR,HIF1A,HPD,HUS1,ICAM1,IER3,IGF1,IGFBP7,IKZF2,IKZF5,IL10RB,IL17A,IL17RA,IL1R1,IRF5,IRS1,IRS2,ITGA3,ITGB2,JAG1,KIF11,KIF18A,KLF4,LAMP2,LCP2,LPL,LRAT,MAFA,MAP1LC3B,MAVS,MB,MRPL34,MRPL45,MRPL46,MRPS12,MRPS30,MVD,MYCN,MYL3,MYOG,NCAPG,NDN,NDUFA7,NDUFAF2,NRP2,PDK4,PLA2G2D,PNPLA2,PPARG,PPARGC1B,PRC1,PRCP,PRDM1,PRKAA2,PRKCD,PTPRB,PTPRC,Ptprv,RAB7A,Rcan1,RUNX2,SEMA6D,SERPINE1,SESN1,SGK1,SLC25A15,SLC25A22,SLC25A24,SLC25A25,SOX10,SPC25,SREBF1,STAT5B,Tcf7,TGFB1,THBS1,TIMM50,TKT,TNNC1,TNNT1,TRADD,TRIM63,UBASH3B,VCAM1,WNT16,WNT4 | 1602 (20) |
| NMDA Receptor | NA | complex | NA | -2.20e-01 | NA | 0.0e+00 | ATF3,BDNF,CAMK2A,HOMER1,NCAM1,NOS1,NTRK2,PENK,SYP | 1255 (20) |
| W7 | NA | chemical reagent | NA | -2.20e-01 | NA | 2.0e-02 | BIRC3,Calm1 (includes others),CD83,CD86,COL2A1,MYH7,NR4A1,STAR | NA |
| EPC1 | 7.00e-01 | transcription regulator | NA | -2.20e-01 | bias | 0.0e+00 | ACTA1,CKM,MYOD1,MYOG | 512 (7) |
| FKBP8 | 4.00e-01 | other | NA | -2.20e-01 | NA | 1.0e-02 | GLI1,HIF1A,PTCH1,SDC1 | NA |
| MED12 | 3.80e-01 | transcription regulator | NA | -2.20e-01 | NA | 3.0e-02 | ANKRD1,BMP4,CREB5,EGR2,FOXP3,GLI1,KITLG,POLE4 | NA |
| AICAR | NA | chemical - endogenous mammalian | NA | -2.20e-01 | NA | 0.0e+00 | ABCA1,ABCG1,ACTA1,ACTA2,ARG1,CASP3,CCND1,CCNE2,CDKN1A,COL1A1,COL3A1,COX4I1,FN1,FOXO1,GPX3,GPX8,HDAC4,LCAT,MKI67,MMP2,MSTN,MYOD1,MYOG,PDK4,PNPLA2,PPARD,PPARG,PRDX1,RUNX2,SERPINE1,SOCS3,SREBF1,STAR,TGFB1,UCP3 | 1315 (22) |
| 740 Y-P | NA | chemical reagent | NA | -2.20e-01 | NA | 0.0e+00 | Ccl2,CDH1,CDH2,ICAM1,SNAI1,VIM | 820 (10) |
| IGBP1 | 5.40e-01 | phosphatase | NA | -2.20e-01 | NA | 0.0e+00 | CASP1,CDH1,CLDN1,CLDN3,ELAVL1,IRF1 | 664 (9) |
| NUMB | -1.60e-01 | other | NA | -2.20e-01 | NA | 3.0e-02 | BCL2L1,BIRC3,CDKN1A,HEY2,IFI16,PROM1,TRPC6 | NA |
| A2M | -1.42e+00 | transporter | NA | -2.20e-01 | NA | 3.0e-02 | Ccl2,CCND1,CDH1,CDH2,CREB1,EIF2AK3,FOXO1,GADD45B,GAP43,SLC2A1,SREBF1,WNT10B,WNT5A | NA |
| DHX36 | -6.00e-01 | enzyme | NA | -2.20e-01 | NA | 0.0e+00 | ACTN2,ANKRD1,CASQ2,FHL1,HEY2,KCNH2,MYBPC3,MYH6,MYH7,TNNC1,Tpm1 | NA |
| PRKCZ | -8.70e-01 | kinase | NA | -2.30e-01 | NA | 1.0e-02 | ABCA1,CASP3,CCND1,CD1D,CDH1,ETS1,HIF1AN,MAPK3,MMP2,NFKBIA,PHGDH,VCAM1 | NA |
| rolipram | NA | chemical drug | NA | -2.30e-01 | NA | 0.0e+00 | ANXA1,BCL2L11,BDNF,CASP1,CD86,CXCR4,DUSP1,ENTPD1,IL1R1,IL1RN,NLRP3,NTRK2,PDE1A,PTGS2,PYCARD,SFTPB,SOCS3,TGFB1,TLR5,TLR7,TLR8 | 1187 (16) |
| acriflavine | NA | chemical toxicant | NA | -2.30e-01 | NA | 2.0e-02 | ADIPOQ,CA9,CD47,PTPRB,SOCS3 | NA |
| GALNT6 | -8.00e-01 | enzyme | NA | -2.40e-01 | NA | 0.0e+00 | ANPEP,CDH1,CDH2,DPP4,EPHB2,FN1,LGR5 | NA |
| NFASC | 5.00e-01 | other | NA | -2.40e-01 | NA | 2.0e-02 | BCAN,GLDN,KIF5A,KIF5C,KLC1,NRCAM,SCN1B | NA |
| sorbitol | NA | chemical - endogenous mammalian | NA | -2.40e-01 | NA | 1.0e-02 | BCL2L1,CDKN1A,ERRFI1,RGS7,SGK1,SLC1A3,SORD | 1257 (20) |
| ZNF106 | -6.00e-02 | other | NA | -2.40e-01 | NA | 0.0e+00 | ACTC1,C3,CXCL10,GADD45GIP1,GLRX,GPNMB,HBA1/HBA2,IFITM3,LGALS1,MPZ,NCMAP,PMP2,PMP22,PRX,SSPN,TMEM106B,UGT8 | NA |
| 1-(ethylthio)-4-(2-phenylethyl)-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1’-cyclohexan]-5(7H)-one | NA | chemical reagent | NA | -2.40e-01 | NA | 1.0e-02 | CDH1,CDH6,COL2A1,CSF1,F2R,FBN1,FGF2,FN1,HDAC7,MPZ,NOTCH4,NR2F1,SOX10,SPDEF,TGFB1,TWIST1,TWIST2 | NA |
| Arntl-Clock | NA | complex | NA | -2.40e-01 | bias | 2.0e-02 | DBP,HIF1A,HLF,NR1D2,PER1 | NA |
| CEACAM1 | -1.25e+00 | transporter | NA | -2.50e-01 | NA | 0.0e+00 | ALDH1A1,ANGPT2,CD36,CD86,COL18A1,CXCR4,DLL1,GFAP,ICAM1,IL2RB,IL2RG,KDR,TEK,VEGFC,VEGFD | 1400 (16) |
| CDX2 | NA | transcription regulator | NA | -2.50e-01 | NA | 1.0e-02 | AXIN2,CASP1,CAV1,Ccl2,CD9,CDH1,CDKN1A,CLDN1,CTSE,DHRS9,DLL1,ETS1,EZR,FGF1,GLI2,HOXA5,HOXB5,HOXD4,ITGB4,KCNJ15,KLF4,KLF5,LAMC2,LAMP2,LEF1,LMX1A,MYCN,NLRP3,NR2F2,NTS,PAX3,PRDM1,RAB8A,SALL4,SLC26A3,SLC7A8,SNAI1,TAL1,TGFB1,VTI1A | NA |
| CADPS | -7.50e-01 | other | NA | -2.50e-01 | NA | 2.0e-02 | BDNF,CDH1,CDH2,SNAI1 | NA |
| GJA1 | -1.70e-01 | transporter | NA | -2.50e-01 | NA | 0.0e+00 | BMP4,CCND1,CDH1,CDH2,CDKN1A,FOXO1,GJB2,ICAM1,IL2RA,PTGS2,SKP2,SPP1,THBS1,TNFRSF11B,VIM | 1481 (20) |
| riluzole | NA | chemical drug | NA | -2.50e-01 | NA | 1.0e-02 | BDNF,GFAP,GRIN3A,HOMER1,INHBB,NAV1 | 834 (15) |
| TFAP2A | -4.60e-01 | transcription regulator | NA | -2.60e-01 | NA | 0.0e+00 | ABCA1,ADAM17,ALCAM,ANXA1,BCL2L1,BIRC3,CCND1,CDH1,CDKN1A,COL7A1,CX3CL1,E2F2,E2F8,EYA4,EZH2,F2R,FOXP3,FREM2,GLO1,GM2A,ITGBL1,KITLG,KLF4,KLHDC3,LACTB,MCM7,MMP14,MMP2,NOS1,PITX2,PPARD,PPARG,PRDX1,RPL6,SERPINE1,SESN1,TIMP1,TYMS | 1350 (21) |
| RXRB | 5.00e-01 | ligand-dependent nuclear receptor | NA | -2.60e-01 | NA | 1.0e-02 | ABCA1,ABCA4,ACSL1,ALDH1A1,CAMK1D,CD109,CD86,CDK6,COLEC12,CRYAB,CTSS,CXCL10,ECM1,ECT2,EHD3,FABP1,FGFR1,FLRT3,FSTL1,GADD45G,GPR183,IGF1,IGFBP6,ITGB3,LSR,MAP1B,MMP2,MTERF3,NRK,OSMR,PDGFB,PES1,PLCL1,PMP22,RBPJL,RGN,S100A4,S100A6,SELP,SLAMF1,SPP1,SREBF1,VCAN | 1504 (21) |
| HDAC3 | 2.10e-01 | transcription regulator | NA | -2.60e-01 | NA | 0.0e+00 | ALDOA,ALOX5,ARG1,BIRC3,CCND1,CD34,CD36,CDH1,CDH2,CDKN1A,CXCL10,DIO1,E2F2,ELOVL5,FITM1,G6PD,GDF11,GPAM,ICAM1,NFKBIA,PGK1,PKM,PRDM1,PTGS2,SERPINE1,SLC2A1,SMAD7,SNCA,SPP1,TAGLN,TBX5,TNNI2,USP18,VIM | 1573 (22) |
| ARNT | 3.40e-01 | transcription regulator | NA | -2.60e-01 | NA | 0.0e+00 | ACER2,ADAM17,AHR,AHRR,ALDOA,ARID5B,BAMBI,BATF,BHLHE40,CA9,CAV1,CCND2,CCR5,CITED2,CLDN1,COX6B1,CRYAB,CXCL10,CXCR4,CYP1B1,CYP2S1,EDN1,EIF6,ENG,ESRRG,F5,G6PD,GADD45B,GAPDH,GPI,HGF,HIF1A,ID2,IL1R1,IRS2,ITGB3,LOXL2,OAZ1,PCDH18,PGK1,RANBP1,SERPINE1,SIM1,SLC2A1,SOCS3,SPP1,TIPARP,TNFRSF19,VEGFD,VIM | 1721 (23) |
| EIF2AK3 | -6.50e-01 | kinase | NA | -2.70e-01 | NA | 0.0e+00 | ALDH18A1,ARFGAP1,ARFGAP3,ASNS,ATF3,ATP2A2,BCL2L11,BDNF,BIRC3,BTG2,CA9,Ccl2,CCND1,CLCN3,CTSC,EDEM1,EGR1,EIF2AK3,EIF4EBP1,ERO1B,FGF2,GADD45A,GCH1,GOLGA4,GORASP2,HERPUD1,IGF1,KDELR2,KLF4,MAP1LC3B,NAPA,NFIL3,PON2,PRDM1,SCN5A,SEC24D,SIAH2,SLC1A4,SLC7A1,ZFP36 | 1336 (21) |
| methylnitronitrosoguanidine | NA | chemical toxicant | NA | -2.70e-01 | bias | 0.0e+00 | BTG1,BTG2,CCND1,CDKN1A,CEACAM1,EGR1,GADD45A,IRF1,KLF10,PLAT,SERPINE1 | 1340 (17) |
| METTL3 | 2.30e-01 | enzyme | NA | -2.70e-01 | NA | 0.0e+00 | ACAD11,ADAMTSL4,ANXA1,ASAP3,BTG2,Ccl2,CD36,CD9,CDH3,CDKN1A,CGREF1,CISH,CX3CR1,CXCL10,DENND2C,EGF,ELAVL1,Esrra,HYAL1,ICAM1,ISG15,KLF4,KLHL26,LPIN1,MCTP2,MYBL1,NDUFC2,Nlrp1a,NR4A1,PLTP,PTP4A3,SCN3B,SOCS1,SOCS3,TBC1D8,TIMP1,TMC7,TRIM7,WDR35,WNT9A,ZNF385A | 764 (19) |
| nelfinavir | NA | chemical drug | NA | -2.70e-01 | NA | 0.0e+00 | ADIPOQ,ALDH1L2,ARHGEF2,ASNS,ATF3,CHAC1,DDR2,DENND2D,FAM102A,GPT2,HERPUD1,HHIPL1,JAG1,KLF4,LONRF1,MTHFD2,NFIL3,NNMT,PLIN1,PLIN4,PPARG,SLC1A4,SLC6A9,SYBU,TNFRSF11B | NA |
| ACOX1 | -1.80e-01 | enzyme | NA | -2.80e-01 | NA | 0.0e+00 | ACADL,ACER2,ACSL1,ADAMTS1,ANXA2,CD36,CDKN1A,CSTB,CTSE,CXCL12,CYP7B1,DIO1,DPP4,GADD45A,HLA-DQA1,HPD,IGF1,KLF6,LPL,NFE2L2,PDK4,PHLDA1,PIGP,QPCT,RGN,RGS2,RPS24,SELENBP1,SGK1,SLC16A1,SLC20A1,SLC37A4,SLC4A4,SLCO2B1,TAGLN2,TNFRSF10A,TRPV2,UGCG,UGT8 | 1279 (15) |
| PBX1 | -4.40e-01 | transcription regulator | NA | -2.80e-01 | NA | 0.0e+00 | AMD1,ANGPT2,CDH1,CDKN1A,COL1A1,COL5A2,CYBB,ETV1,FGF2,MYOG,NCF2,NFIL3,PAX3,VCP | 31 (2) |
| METTL1 | 1.80e-01 | enzyme | NA | -2.80e-01 | NA | 2.0e-02 | ACTA2,CCNA2,CCND1,CDH1,CDK6,SNAI1,VIM | NA |
| T 0070907 | NA | chemical reagent | NA | -2.80e-01 | NA | 2.0e-02 | ADIPOQ,Ccl2,CDKN1A,COL1A1,PTGS2 | NA |
| CNB-001 | NA | chemical reagent | NA | -2.80e-01 | NA | 2.0e-02 | ALOX5,ASNS,ATF3,BDNF,HERPUD1 | NA |
| PNN | 0.00e+00 | other | NA | -2.80e-01 | NA | 4.0e-02 | BCL2L1,CDH1,CDKN1A,RHOA,SRSF1,TIMP1 | NA |
| pituitary adenylate cyclase-activating polypeptide | NA | biologic drug | NA | -2.80e-01 | NA | 0.0e+00 | ACER2,AGL,AXIN2,BAMBI,CCND1,CCND2,CRYAB,DPYSL3,DUSP6,EGR1,EPHA4,ERRFI1,GCH1,ITGA1,MACROD1,MYCN,NKD1,PLK2,RET,SEMA6D,SLC41A2,WNT4 | NA |
| ARID1A | -9.00e-02 | transcription regulator | NA | -2.90e-01 | NA | 0.0e+00 | ACSL1,ACTA2,AGL,ALDH1A1,ANXA1,AXIN2,BMP4,C8orf44-SGK3/SGK3,CA9,CCDC80,CD83,CDH1,CDKN1A,CEACAM1,CHST10,CKM,CMTM7,COL1A1,COL7A1,COLEC12,COX6B1,CSPG4,CXADR,DPYSL3,EDIL3,EEF1A2,EPHB2,EPS8L2,ERBB3,EZR,F2R,FBLN1,FHL1,FN1,FSCN1,FZD1,FZD2,FZD4,FZD5,GLIPR2,GNG10,IRS2,ITGA5,ITGA6,ITGB4,KCNT2,KLF4,KRT19,L1CAM,LGR5,LIMS1,LSR,MIA,MSLN,MSN,MYOG,NADK2,OCLN,P3H2,P3H4,PDK2,PGK1,PKM,PLEKHO2,PLOD2,PLXND1,PMP22,PTGFRN,PTGIS,RGP1,RNF144A,SIX2,SNAI1,SRP68,STAT6,TLE1,TNC,TP63,TPST1,UQCC3,VIM,WNT2B,WNT4,WNT5A,WNT6,ZFPM2 | 1624 (22) |
| ochratoxin A | NA | chemical toxicant | NA | -2.90e-01 | NA | 4.0e-02 | BCL2L1,CASP3,CDH1,CDH2,COL3A1,DDAH1,GCLC,TIMP1 | NA |
| deferoxamine | NA | chemical drug | NA | -2.90e-01 | NA | 0.0e+00 | ALDOA,ANGPT2,ANGPT4,ANXA2,APLN,BACH1,BDNF,BHLHE40,CA9,CACNA1E,CACNA1G,CACNB4,CCND1,CCND2,CD47,CDH1,CDK2,CDKN1A,CITED2,CP,CYTH1,DUSP1,DUSP10,DUSP5,ECM1,EGLN1,ELN,ERRFI1,ESRRG,F13A1,F3,FAM20C,FIS1,GADD45A,GADD45B,GAS7,HIF1A,HSPA1A/HSPA1B,HTR2B,ICAM1,IFI16,IGF1,IGFBP4,IGFBP5,ISCU,ITGB2,ITGB7,KIT,LAMA3,LPL,LRRC25,LY75,MAP1LC3B,MAPK14,MMP2,MS4A6A,MYCN,NFATC4,NFIL3,NR4A2,PFKFB1,PFKFB3,PGK1,PKM,PLA2G4A,PLAT,PPARG,PROM1,RSAD2,SELE,SERPINB8,SERPINE1,SHMT1,SLC2A1,SMAD7,SPP1,SPRY4,SREBF1,SULF2,TEC,TGFB1,UBE2E1,VCAM1 | 1419 (19) |
| trifluoperazine | NA | chemical drug | NA | -2.90e-01 | NA | 2.0e-02 | CCNE2,EGR1,HIF1A,NOS1,PROM1 | NA |
| IGFBP5 | -8.80e-01 | other | NA | -3.00e-01 | NA | 0.0e+00 | BCL2L1,BHLHE40,CCND1,COL1A1,EGR1,F3,IGF1,IRS1,MPZ,MYH7,PFKFB3,RUNX2,SERPINE1 | 1480 (22) |
| 11,12-epoxyeicosatrienoic acid | NA | chemical - endogenous mammalian | NA | -3.00e-01 | NA | 0.0e+00 | ADIPOQ,CD44,DUSP1,ICAM1,NFKBIA,PIK3CG,PLAT,PPARG,SELE,VCAM1 | 1363 (22) |
| SPARC | -1.29e+00 | other | NA | -3.00e-01 | NA | 0.0e+00 | ABCC4,BARD1,BHLHE40,BRCA2,CASP1,CDH1,CDH3,CEBPD,CIART,CLDN1,COL1A1,DAB1,DVL1,FANCB,FN1,GPD1,ISG15,LEF1,LOXL4,MAP2,MBD4,MID2,MMP2,NIPAL1,NOTCH2,PIK3C2G,SERPINE1,SNAI1,SNAI2,SPARC,STAT1,TBX3,TGFB1,TMEM45A,TSKU,VIM | 1413 (25) |
| LGALS1 | 6.00e-01 | other | NA | -3.00e-01 | NA | 0.0e+00 | ACTA2,AHR,Ccl2,CCL21,CCND2,CCR1,CDKN1A,COL1A1,CXCL14,CXCL16,DHCR7,F3,FIS1,FN1,GALNT16,GLI1,GPAT3,GPCPD1,HRAS,ICAM1,IL17A,IL2RA,LGALS1,MAF,MAP2K4,MMP2,NTRK2,PTCH1,PTX3,ROCK1,SERPINE1,SNAI1,SOCS3,SPP1,TGFB1,TOX | 1320 (17) |
| diphtheria toxin | NA | chemical - endogenous non-mammalian | NA | -3.00e-01 | NA | 0.0e+00 | ABCA1,ACTA1,ADAM19,AGMO,ANO6,BCL3,CASP1,Ccl2,CD74,CFH,CLEC4A,CLEC4M,COL12A1,COL3A1,COL6A3,COL8A1,DONSON,DUSP6,EGF,ERBB3,GCA,GPR183,HHEX,IL1RL2,KIF11,LGALS1,NLRP3,NOTCH2,OASL,PDGFC,PENK,PFKFB3,PIK3R1,PLA2G2D,PLA2G7,PON3,RASSF5,S100A10,SLC25A28,SOCS3,SPRED1,Tlr12,TLR2,TMEM132A,TNNI2,TRPM2,VAV3 | NA |
| CYP1A1 | 6.10e-01 | enzyme | NA | -3.00e-01 | NA | 0.0e+00 | ACOT11,BANF1,CCND1,CHP1,CHRNA4,COX6B1,ETHE1,GAMT,IFNLR1,IGF1,INSC,KITLG,KRT19,LMNB2,MID1,Mt1,MYO10,NDUFA1,NDUFV1,NEFL,PFDN1,PTP4A3,RBBP4,SDC1,SLC46A3,TACC3,TNNT2,WEE1 | NA |
| TIMP1 | -1.58e+00 | cytokine | NA | -3.00e-01 | NA | 2.0e-02 | BCL2L1,CD44,CDKN1A,HGF,IL33,MET,MME,MMP2,PLAT,PLTP,ST14 | NA |
| EPHX2 | -2.90e-01 | enzyme | NA | -3.10e-01 | NA | 1.0e-02 | ACTA2,BDNF,Ccl2,DLL1,ICAM1,RUNX2,SELE,TAGLN,VCAM1 | 1134 (19) |
| PCSK9 | NA | peptidase | NA | -3.10e-01 | NA | 0.0e+00 | ANXA1,Ccl2,Ccl7,CD36,CD9,CDKN1A,ICAM1,IFITM3,IL1RL1,ISG15,OLR1,PNPLA3,STX11,STX3,TLR2 | 781 (11) |
| Cyp2c23 | -6.60e-01 | enzyme | NA | -3.10e-01 | NA | 2.0e-02 | ASPA,Ccl2,CCNA2,CD86,CX3CR1,F5,ITGAE | NA |
| zerumbone | NA | chemical - endogenous non-mammalian | NA | -3.10e-01 | NA | 4.0e-02 | BCL2A1,BCL2L1,BIRC3,CASP3,CCND1,ICAM1,PTGS2,TNFRSF10A | NA |
| thiazolidinedione | NA | chemical drug | NA | -3.10e-01 | NA | 0.0e+00 | ABCG1,ADIPOQ,IRS1,IRS2,NR4A1,NR4A2,NR4A3,PIK3R1,SPHK1 | 1478 (23) |
| DNMT1 | -1.60e-01 | enzyme | NA | -3.10e-01 | NA | 0.0e+00 | CA9,CDH1,CDKN1A,CMTM5,CNR1,CSF1,DAB1,DLC1,EZH2,FBN1,FOXP3,GATA4,KCNA1,KIT,Mt1,NEIL1,PPARG,PRDM16,PTGS2,PTN,PYCARD,RELN,RGMA,RGS10,SFRP2,SFRP4,SFRP5,SOCS1,WNT5A | 1586 (23) |
| PROX1 | -2.41e+00 | transcription regulator | NA | -3.10e-01 | NA | 0.0e+00 | ALCAM,ANGPT2,CCNE2,CD34,FGFR1,FOXC2,ITGA9,KDR,MYL1,NRP1,RGS4,STAT6,SYP,THY1,TNNI2 | 841 (7) |
| RUNX1 | -7.90e-01 | transcription regulator | NA | -3.20e-01 | NA | 0.0e+00 | ADAMTSL4,ALCAM,ALOX12,ANK1,ANXA2,ATF3,BANK1,BCL2L11,BCL2L12,BDH1,BTG2,CCND1,CCND2,CD22,CD244,CD34,CD53,CDKN1A,CHI3L1,CPA3,CSF1,CSF1R,CSF2RA,CSF2RB,CST7,DEPTOR,EDEM1,EGR2,ENG,EPB42,FOXP3,FSCN1,FUT7,GPAM,GPATCH4,HBA1/HBA2,HEY2,ID2,IFITM3,IL17A,IL2RA,IRF5,ISG15,ITGA2,ITGA2B,ITGA4,ITGA9,ITGAL,ITGB2,ITGB3,KIT,LCP2,LGALS9B,LMO1,LTB4R,MAP3K6,MET,mir-143,Mt1,MYH10,NCAM1,NFIL3,NOP2,NR2F2,NR4A3,OAS3,Oasl2,PCDH7,PIK3R1,PLEK,PLXND1,Pmaip1,Podxl,PPAN,PRKCB,PRKCQ,PTCH1,RGCC,ROCK1,RRP9,RSAD2,RUNX1,RUNX2,SERPINE1,SGPP1,SLAMF1,SOX6,Sp100,SPP1,SPTB,STAT1,STX3,TAL1,Tcf7,TIMP1,TRIB1,TSPAN33,UBE2L6,UGCG,UNC5B,ZBTB16 | 1608 (22) |
| MAP3K8 | 1.10e-01 | kinase | NA | -3.20e-01 | NA | 0.0e+00 | ADCY7,ARG1,ARRDC3,BIRC3,BMP1,CACNB3,CASP8,CBFB,Ccl2,CCR1,CCR5,Cd33,CDK5R1,CEBPD,CIITA,COBLL1,COLEC12,DOK2,DUSP6,EGR1,FAM107B,FSCN1,GAB1,GCA,GPR160,GPR171,GPR176,IER3,IER5,IL4I1,INHBA,KIF5C,LAD1,NFAM1,NR4A1,P2RY1,PLAT,PPARGC1B,PTGS2,RASGRF1,RCSD1,RHOF,SESN1,SIX1,SLA,SLCO4A1,SOCS3,TMEM143,TSPAN33 | 1401 (15) |
| LMNA | -3.10e-01 | other | NA | -3.20e-01 | NA | 0.0e+00 | ABCC8,ACKR4,ACTA2,ADAMTS10,ATG2A,BAMBI,CAAP1,CAMK1D,CAMK2A,CD28,CD93,CERS6,CFL1,COL11A1,COL12A1,COL1A1,COL3A1,COL8A1,DCN,EDN1,ELN,ENTPD1,EPB41L3,FN1,FNIP1,GATA4,GCLC,GHDC,GRAP,GULP1,HAS3,HEATR5A,HTRA3,IER5,IFI44,IFIH1,IRF1,IRF8,JAZF1,JUND,KLF15,KLF5,LPAR4,LPL,MAFF,MMP14,MMP15,MYF5,MYH7,MYL2,MYOD1,MYOG,NPR2,PCDH7,PCGF6,PDP2,PLD2,PNPLA2,PPARG,PPARGC1B,PPM1H,RHPN2,SEMA7A,SFXN1,SKAP2,SLC36A1,SLC38A2,SLC41A2,SPP1,SREBF1,STAT1,SYT3,TEC,TGFB1,TMEM164,TMEM64,TNMD,UBA7,VCP,ZBTB38,ZFP36,ZFP64,ZNF397 | 1263 (19) |
| GLI1 | -1.51e+00 | transcription regulator | NA | -3.30e-01 | NA | 0.0e+00 | ABCC3,ABCG1,ACTA2,AHNAK2,ALOX5,ANO1,ANXA1,ARHGAP28,ARHGAP29,ATF3,ATP9A,B3GALNT1,BCL2A1,BCL2L1,BCL2L11,BCL6,BIRC3,C1QTNF3,CA12,CAV1,CAV2,Ccl2,CCND1,CCND2,CD44,CDC34,CDH1,CDH11,CDK2,CDK6,CDKN1A,CEP70,CFL2,CHI3L1,CMPK1,COL1A1,COL2A1,CSF1,CSRNP1,DBP,DUSP5,DUSP6,EGR1,EGR3,EIF5A2,EMB,EMP1,ENDOD1,EPB41L4B,EPHB6,ETV5,EZR,FGF1,FGF10,FHL1,FOXC2,FOXO1,GADD45B,GAS2L3,GATA4,GDA,GJA3,GLI1,GLI2,GNAL,GPC3,GREM2,HEY2,HNRNPU,HOXA5,HOXB5,HPSE,HUS1,ID2,IER3,IGF1,IGFBP6,IGFBP7,IL17RD,IL2RA,IL33,IQGAP2,IQGAP3,IRS1,ITGA3,ITGB4,ITPKB,KBTBD8,KIT,KITLG,KLF4,KLF5,KLF6,KLF9,KNL1,KRT19,LGALS1,LRRC1,LZTS1,MAFF,MALL,MAN1C1,METTL21A,METTL7A,MICAL2,MIDN,MKI67,MMP2,MSI2,MTMR1,MTURN,MYADM,MYCN,NAB2,NAV3,NFAT5,NIPAL2,NPEPL1,NR1D2,NR2F2,NUDT4,PAM,PCDH18,PCDH7,PCOLCE2,PDGFRA,PDK4,PDZRN3,PGM2L1,PITPNM3,PLEKHA8,PLPP2,PLXDC1,PPM1A,PRAG1,PRKCE,PRKCI,PSTPIP2,PTCH1,PTGS2,PTPRF,RGS10,RGS14,RNASE4,RUNX2,RXRA,S100A11,S100A4,S100A6,SAP30L,SCARA3,SCD5,SDC4,SELENBP1,SELENOP,SERTAD4,SESN1,SFRP1,SGO2,SIX4,SKP2,SLC1A3,SNAI1,SOCS1,SOCS3,SOWAHC,SOX18,SOX6,SPP1,SPRED1,SPRY4,STX3,SYT17,SYTL2,TBX3,TIMP1,TM4SF1,TNC,TNNT1,TSPAN1,UACA,UBALD2,VEGFC,VIM,WNT2B,WNT5A,ZC3HAV1L,ZFP36,ZSWIM6 | 1617 (21) |
| doxycycline | NA | chemical drug | NA | -3.30e-01 | NA | 0.0e+00 | ADGRE1,ASNS,BCL2L1,Ccl2,CD86,CDH1,CDK2,CEBPD,CHAC1,COL3A1,CSF3R,CXCL12,EGR2,FGF2,HSPA1A/HSPA1B,IL2RA,L1CAM,MAPK14,MITF,MMP2,NFE2L2,PLK3,PRDM1,PTGS2,SDC1,SNAI1,SOCS1,SOX10,TIMP1,TLR2,TSHR,TWIST1 | 895 (15) |
| SIRT2 | 6.00e-01 | transcription regulator | NA | -3.30e-01 | NA | 2.0e-02 | AACS,CXCL10,DHCR7,ISG15,LSS,MVD,MVK,MYH6,Oasl2 | NA |
| NKX2-2-AS1 | NA | other | NA | -3.30e-01 | bias | 3.0e-02 | AK4,Akr1b10,Cox8b,EBF2,FAM162A,MRPS23,PDK4,PRDM16,SLC25A51 | NA |
| NFYB | -1.00e-01 | transcription regulator | NA | -3.40e-01 | NA | 0.0e+00 | ACTA2,AMD1,BCL11B,BCL2L1,BCL2L11,CAV1,CDH1,CDH2,CENPF,COL1A1,CPEB3,CSDE1,CYTIP,DCLK3,DPP4,EIF3C,ELAVL1,EMX2,FBXL18,FLRT2,FLT3LG,GADD45A,GAPDH,GDF6,GPAM,GPR160,HCCS,HLA-DRA,HMGN3,IGF1,ITM2C,KBTBD8,KCTD1,KHDRBS3,LPIN1,METTL9,MSRA,MVK,NKX6-1,NOSIP,NPR1,PAQR5,PDIA4,PGRMC1,PITPNM3,PLK1,PTPN6,RIMBP2,RORB,RUNX2,S100A4,SALL4,SESN1,SHOX2,SLC25A28,SLC39A8,SLIT3,SLITRK2,SNAI1,SPECC1,ST8SIA4,TM7SF3,TOP2A,TWIST1,TYMS,UBE2D3,UHRF1,VIM,VWF | 760 (7) |
| miR-381-3p (and other miRNAs w/seed AUACAAG) | NA | mature microRNA | NA | -3.40e-01 | bias | 0.0e+00 | CCNA2,CDK6,KLF9,MET | NA |
| HOXA3 | 3.00e-01 | transcription regulator | NA | -3.40e-01 | NA | 0.0e+00 | ALOX5,ANXA2,DAPP1,ENG,EVI2A,HBA1/HBA2,HEY2,IL17RA,ITGA4,NR2F2,PIK3CG,PLEK,PLXND1,PRKCD,PSTPIP1,RAC2,ROCK1,RUNX1,SLAMF1,STAT6,Tcf7,TNFRSF1B,UNC5B | NA |
| mir-24 | NA | microRNA | NA | -3.50e-01 | NA | 1.0e-02 | AHR,ARHGAP19,BCL2L11,CDH2,CDKN1A,FN1,ID2,IL17A,IL2RA,KDR,MAF,NET1,PRDM1,SERPINE1,SNAI2,Tcf7,TGFB1 | 1348 (14) |
| IFRD1 | 1.40e-01 | other | NA | -3.50e-01 | NA | 1.0e-02 | EBP,FEM1A,HK1,IGF1,LAMA2,MYH8,MYOD1,MYOG,PPIA,RPL22,SPP1 | 1088 (7) |
| HDAC1 | -2.00e-01 | transcription regulator | NA | -3.50e-01 | NA | 0.0e+00 | ADIPOQ,AKAP12,ALCAM,AMPD3,ANGPT2,ATF3,AXIN2,BAMBI,BCL6,BDNF,BRCA2,CCNA2,CCND1,CCND2,CCNE2,CD1D,CD34,CD44,CDH1,CDK2,CDKN1A,CEACAM1,COL1A1,COL2A1,CSF1R,CTSK,DAB2IP,DUSP1,E2F2,EGR1,FABP1,FAM107A,FN1,FOXP3,GABARAPL1,GLI1,GLUL,GNAS,IL17A,ITGAD,ITGB4,KDR,LGR5,LMO2,MAD1L1,MCM7,MME,MPZ,Mt1,MYH7,MYO1F,NFKBIA,NKD1,PAX3,PDGFB,PFKFB3,PLK1,POLE4,PPARG,PPP2R2B,PRAG1,PREX1,PTGS2,PTPN6,RBL1,RECK,RGS10,RUNX2,SERPINE1,SFRP1,SGK1,SLC35D1,SMAD7,SNAI1,SNAI2,SOX10,SPP1,SREBF1,TAGLN,TAL1,TBX5,TNFRSF19,TNNI2,TOP2A,TYMS,UCP3,UHRF1 | 1605 (23) |
| KAT2B | -1.30e-01 | transcription regulator | NA | -3.50e-01 | NA | 2.0e-02 | ALDOA,B2M,CDKN1A,CKM,EDEM1,FGR,FOXP3,GLI1,HIF1A,ISG15,PFKFB3,PGK1,PKM,PTCH1,PTGS2,SLC2A1 | NA |
| acetaminophen | NA | chemical drug | NA | -3.50e-01 | NA | 0.0e+00 | A2M,ABCC3,ABCC4,ABCC5,ACOT7,ACOT8,ACTG1,ADH7,AHR,AK4,ALDH1A1,ALOX12,BCKDHA,BLVRB,BTG2,CA3,CASP3,CASP8,Ccl2,CCND1,CCR1,CDKN1A,CRP,CXCL10,CYP1B1,DMBT1,EPHX1,FABP1,FTL,GADD45A,GCLC,GLRX,GLUL,GSR,HIF1A,HSD17B4,ICAM1,IDH1,IGF1,IRS1,KDR,LCAT,MGST1,Mt1,NFE2L2,PLA2G7,PNPLA2,PPARG,PPARGC1B,PRDX1,PRKCB,PTGS2,RXRA,Scd2,SELENOP,SERPINF1,SOCS3,TKT,TUBA1A,TUBB,UGDH,VCAM1 | 1365 (16) |
| RUNX1-RUNX1T1 | NA | fusion gene/product | NA | -3.60e-01 | NA | 0.0e+00 | ALOX5,ASPA,ATF3,BRCA2,C5AR1,Ccl7,CDKN1A,CHST11,CST7,CYP2S1,DUSP6,ELF4,FOXO1,GRK5,HNRNPR,HOMER1,ID2,IFITM3,IL1R1,ITGA2,MTSS1,NAV1,PXDC1,RBM28,RCBTB2,RND3,RNF144A,RPL37A,SCN1B,TGFA,TSPAN18,UBASH3B,USB1,XYLT1,ZBTB16,ZBTB24,ZFP36L1,ZFP36L2,ZNF385A | 927 (9) |
| arachidonic acid | NA | chemical - endogenous mammalian | NA | -3.60e-01 | NA | 0.0e+00 | ABCA1,ABCG1,BCL2A1,CD36,CD83,CD86,EDN1,EGR1,F3,FABP1,FADS1,FADS2,G6PD,GLI1,IL17A,ITGB3,KDR,KLF6,MRC1,NFKBIA,PENK,PLA2G2A,PLA2G4A,PLD1,PLTP,PNPLA2,PPARG,PRKCB,PRKD1,PTGES,PTGS2,RGS2,RXRA,SELP,SOAT1,SPP1,SREBF1,SRSF3,STAR,TNFRSF1B,VCAM1,VIM | 1017 (19) |
| SIM2 | 5.20e-01 | transcription regulator | NA | -3.60e-01 | NA | 0.0e+00 | CDH1,CDH2,DBN1,GADD45A,IKBKB,MMP2,MRPL58,MYOD1,SNAI2 | 703 (7) |
| TGFBR1 | -5.00e-02 | kinase | NA | -3.60e-01 | NA | 0.0e+00 | ACTA2,AHR,BGN,BHLHE40,BMP4,C3,C3AR1,Ccl2,Ccl7,CCND1,CCR1,CD86,CDH1,CDH2,CDKN1A,CFB,COL1A1,CXCL10,EDN1,EGR2,FBLN5,FGF10,FGF9,FMOD,FN1,FOXP3,HAS2,ID4,IL17A,IL1RN,IL7,ITGB2,JAG1,KLF4,LTBP1,OSR1,PDGFB,PDK4,PPIA,PRKCB,PTX3,RUNX1,SCX,SERPINE1,SFTPB,SMAD7,SNAI1,SNAI2,STAR,STAT1,TAGLN,TGFBI,TLR7,TWIST1,VEGFC,VIM,WNT11,WNT9A,ZFP36 | 1452 (17) |
| HSF1 | 5.80e-01 | transcription regulator | NA | -3.60e-01 | NA | 0.0e+00 | Abi3bp,ACADL,ATN1,B2M,BCL2L1,BMP4,BUB1B,CCNA2,CD36,CDH1,CELSR1,COBL,COL18A1,CRYAB,CSRP2,DCTPP1,DNAJA1,DNAJB1,E2F8,ELAVL1,FBLN1,FGF1,FMOD,HCK,HSF2,HSP90AA1,HSPA1A/HSPA1B,HSPE1,ICAM1,IGFBP4,INHBA,INHBB,IRS1,KCNF1,KNTC1,LAMA4,LPL,MAT2A,MCM7,MICB,MITF,MMP19,MRPL18,NCOR2,PGK1,PLIN4,PNPLA2,POLA2,PPARG,PPP3CA,PRKDC,PROM2,RANBP1,RPL22,RRAD,SDK2,SEMA3A,SEMA3C,SERPINH1,SGO2,SLIT3,SMTNL2,SNAI2,SNCAIP,SREBF1,SSBP1,STAR,STAT6,THBS2,TRPV1,TUBB4A,Ubb,UBC,UCP3,VCAM1,VCAN | 1663 (19) |
| 3-deazaneplanocin | NA | chemical drug | NA | -3.60e-01 | NA | 0.0e+00 | ADORA2A,ANXA8/ANXA8L1,BCL2L1,CDKN1A,DUSP10,EZH2,FBXO32,FOXO3,FZR1,GPNMB,HIF1A,HOXA5,IL10RA,IRF8,KCNC4,KLF6,MAP3K14,NOTCH2,NOX4,PLXNB1,PPP1R18,SNX33,TGFB1 | 1085 (16) |
| mir-143 | -1.43e+00 | microRNA | NA | -3.60e-01 | NA | 0.0e+00 | CDH1,COL3A1,DMP1,mir-143,MMP2,PDGFRA,PRKCE,PTGS2,SLC2A1,TAGLN | 1219 (14) |
| trabectedin | NA | chemical drug | NA | -3.70e-01 | NA | 3.0e-02 | ARL6IP1,CCND1,CDKN1A,COL1A1,CXCL10,EZH2,G6PD,GADD45A,GZMB,MX1,PPARG | NA |
| MAPK1 | 5.10e-01 | kinase | NA | -3.70e-01 | NA | 0.0e+00 | ADAM17,ADH1C,AKAP12,ANPEP,ANTXR2,APBB3,ARSB,ATF3,ATP1B1,ATP2A1,BCL11A,BDNF,CAV1,CCDC80,CCND1,CD84,CDH1,CDH2,CDK5R1,CDKN1A,CFB,CHST7,CISH,COL7A1,CRYL1,CSGALNACT2,DAB2,DCN,DEPTOR,DMP1,DOCK10,DSE,DUSP1,EGR1,EGR2,EMP1,ENDOD1,ENO3,ERAP1,ERCC1,FBXO32,FCMR,FHL2,FN1,FOXO1,FOXP3,GBP2,GBP5,GNG2,GRAMD1B,HBA1/HBA2,HDC,HOMER1,IFI16,IFI44,IFIH1,IFIT1,IFITM3,IGFBP6,IGFBP7,IL1RL1,IL1RN,IL2RA,IRS2,ISG15,ITGA2B,ITGA5,ITGB3,JUND,L3MBTL1,LAD1,LAMA4,LGALS1,LOX,LZTS2,MAL2,MAOB,MAPK3,MITF,MKI67,MMP2,MMP28,MYH7,MYRF,NFE2L2,NMI,NR4A1,NRP1,NUP210,OAS3,OASL,OLFML2A,OSBPL3,PAQR6,PDGFB,PITX2,PLA2G4A,PLA2G5,PLD1,PLXDC1,POU2F2,PROS1,PRSS12,PTGS2,RCAN3,RGS2,ROS1,SERPINE1,SFRP2,SLITRK6,SNAI1,SP110,SPP1,SPRY4,STAT1,SUOX,TACC2,TDRD7,TNFRSF1B,TSKU,UBE2L6,USP18,VIM,WIPF1,ZC3HAV1 | 1099 (16) |
| selumetinib | NA | chemical drug | NA | -3.70e-01 | NA | 0.0e+00 | BCL2L11,CCND1,CDK5R1,CDKN1A,CSK,DDR2,EPHA4,ERBB3,FGFR1,FGR,FOXO3,FRK,GPNMB,HIF1A,ITGA2,JAK3,LYN,MATK,MET,MITF,MUSK,NTRK2,RET,RUNX2,SLC2A1,TNFRSF10A,TYRO3 | 1410 (18) |
| CUX1 | 6.70e-01 | transcription regulator | NA | -3.70e-01 | NA | 0.0e+00 | ADAM17,ARHGDIB,CCNA2,CCNE2,CDH1,CDH2,CDK2,CDKN1A,CXCL10,CYBB,ECT2,FLNA,HIF1AN,ITGB2,LILRB3,LIMA1,MMP2,MYH7,NCAM1,NDUFA1,OCLN,POLA1,SNAI1,SNAI2,THBS1,VIM,WNT5A,WNT6 | 1192 (12) |
| vincristine | NA | chemical drug | NA | -3.70e-01 | NA | 4.0e-02 | BCL2L1,BRCA2,BUB1B,CDKN1A,EGR1,GAP43,IGF1,LCP1,MAP2K4,MYCN,NCAM1,PTGS2,YWHAQ | NA |
| vorinostat | NA | chemical drug | NA | -3.70e-01 | NA | 0.0e+00 | ABCG1,ACKR4,ADAMTS1,ATP2B4,B3GALT1,BCL2L1,BCL2L11,BIRC3,BRCA2,CARD6,CASP1,CASP3,CASP8,CCND1,CCND2,CCR1,CCR3,CCR5,CD1D,CD276,CD74,CDH1,CDH2,CDK2,CDKN1A,CHKA,CISH,DLC1,DUSP1,EDN1,EGR1,ELAVL1,ELOVL1,FADD,FIS1,HDAC7,ICAM1,IL17A,IRF1,KAT5,KIT,KLF4,KLF5,LGI1,LIPG,LSS,MED26,MICB,MKI67,MMP15,MMP2,MVD,MVK,NFKBIA,OSBPL3,PDGFB,PLIN4,PNPLA3,PRDM1,PTGES,PTGS2,PTP4A3,RGS2,RUNX2,SEMA3A,SNCA,SOCS1,SOCS3,SREBF1,ST14,STAT6,TAL1,TEK,TNFRSF10A,TOP2A,TRADD,VEGFC,VIM | 1555 (15) |
| STRA6 | -2.68e+00 | transporter | NA | -3.80e-01 | NA | 0.0e+00 | PPARG,RARA,RXRA,SOCS3,TGFB1 | 1221 (14) |
| ACVR1C | -1.24e+00 | kinase | NA | -3.80e-01 | NA | 0.0e+00 | BCL2L1,CASP8,CCND1,CDK2,CDKN1A,KLF4,SERPINE1,SMAD7,SNAI1,TWIST1 | 1461 (21) |
| CDK9 | 3.70e-01 | kinase | NA | -3.80e-01 | NA | 0.0e+00 | CCND2,CDKN1A,COL1A1,CXCR4,CXCR5,G6PD,HLA-DQA1,HLA-DRA,MAGI1,NFKBIA,PDK4,PPARG,RUNX1,SELE,SNCA,UHMK1,VIM,WNT5A | 1320 (15) |
| LY6E | -4.40e-01 | other | NA | -3.80e-01 | NA | 4.0e-02 | ABCC3,CD34,CD83,HLA-DRA,IRAK2,NFKBIA,SERPINE1 | NA |
| SOCS6 | 4.00e-01 | other | NA | -3.80e-01 | NA | 5.0e-02 | Ccl7,CEBPD,PLA1A,PLAT,PTGS2,RGCC,SLA | NA |
| STK39 | -4.70e-01 | kinase | NA | -3.90e-01 | NA | 0.0e+00 | CDH1,CDH2,CLDN3,OCLN,SNAI1 | 382 (7) |
| THEM6 | -2.00e-02 | other | NA | -3.90e-01 | bias | 2.0e-02 | ASNS,ATF3,CYB5R2,DHCR7,EDEM1,ERP44,HERPUD1,MSMO1,MVD,PDIA4,PRKAA2 | NA |
| ETV5 | -1.44e+00 | transcription regulator | NA | -3.90e-01 | NA | 0.0e+00 | ALCAM,C5AR1,CAV1,Ccl2,Ccl7,CCND1,CDH1,CDH2,CDKN1A,CHI3L1,CHSY1,CLDN1,CLDN3,CXCL12,CXCR4,CYBB,DPYSL2,EGFL6,EMP2,ETV5,FN1,GCH1,HOPX,ICAM1,ITGA5,KRT19,LCP2,LYN,MAF,MET,MMP14,MMP2,MSN,NFKBIA,NRCAM,PKP3,PMP22,RAB27A,RET,S100A6,SFTPB,SNAI2,SOAT1,SPP1,TINAGL1,TNFRSF1B,TWIST1 | 1331 (21) |
| SUMO2 | 8.80e-01 | enzyme | NA | -3.90e-01 | NA | 0.0e+00 | CAV1,CAV2,CCND2,CEACAM1,CXCL16,ENPP3,Ifgga2l1/RGD1309362,IRS1,ISG15,MMP14,MOXD1,Ndp,NR0B2,PIK3R1,RNASE4,TNC | 1197 (13) |
| miR-22-3p (miRNAs w/seed AGCUGCC) | NA | mature microRNA | NA | -4.00e-01 | bias | 3.0e-02 | ACVR1B,ARID3B,BIN1,CHD7,CLIP2,EDC3,MAX,MTHFD2,RGS14 | NA |
| Mek | NA | group | NA | -4.00e-01 | NA | 0.0e+00 | ACVR1,ANPEP,AXL,B3GALNT1,B3GALNT2,B3GNT2,B3GNT5,BCL2L1,BCL2L11,Ccl2,CCND1,CCND2,CD200,CD36,CDH1,CDH2,CDK5R1,CDKN1A,CRYAB,CSF1R,CXCL10,DDR1,DDR2,DPY19L3,DSE,DUSP5,DUSP6,EDEM1,EGR1,EGR2,EGR3,EPHB2,ERBB3,ETS1,ETV1,ETV5,EXT1,F3,FGFR1,FOXP3,GALNT10,GAP43,GBP2,GCNT2,GDA,GGT5,GXYLT2,HAS2,HIF1A,HOMER1,HRH1,ICAM1,ID2,IER3,Ifi47,IRF1,ITGA2B,ITGA6,ITGB3,KDR,L1CAM,LAMA3,LAMC2,MAF,MAFF,MANSC1,MCOLN1,MME,MMP14,MMP2,MSLN,NCEH1,NOTCH2,NOX1,NOX4,NR4A1,NUP210,PDGFRA,PHLDA1,PLPP3,POLR3G,PTGS2,PTPRF,RND3,ROCK1,RPL23,RUNX1,SACS,SDC1,SEMA3C,SERPINE1,SLC20A1,SLC2A1,SLC7A1,SLCO4A1,SPRED2,SPRY4,ST6GAL1,STT3A,SUSD5,THBS1,TMEM106B,TMEM132A,TMEM259,TOP2A,Tpm1,TSHR,TSPAN1,TWIST1,UGT8,UNC5B,VEGFC,VIM | 1169 (16) |
| PDE4D | 1.70e+00 | enzyme | NA | -4.10e-01 | NA | 0.0e+00 | BCL2L11,CDH1,FN1,MITF,PLAT | 1393 (19) |
| IgG | NA | complex | NA | -4.10e-01 | NA | 0.0e+00 | ADGRE1,ADIPOQ,ADRB2,AHR,ARSB,ATP1B1,B2M,BCL2L1,BCL3,BHLHE40,BIRC3,C3,CARD6,Ccl2,Ccl7,CCND2,CD83,CD86,CD9,CDKN1A,CEBPD,CKM,CLDN3,COL1A1,COL3A1,CSF1,CSNK2B,CTSC,CXCL10,CYP27A1,DHCR7,DUSP1,EDN1,EGR1,EGR2,EGR3,EMP1,ENTPD1,EZR,FCGR1A,FCGR2B,FGL2,FN1,FOLR2,FOXO1,FOXP3,GADD45B,GFAP,GNAS,GPR183,GUK1,HEY2,HIF1A,HTR2B,ICAM1,IFIH1,IFITM3,IL16,IL17A,IL1RN,IL2RA,IL2RG,INHBA,INPP5D,IRF1,IRF3,IRF4,IRS2,ISG15,ITGAL,ITGB2,JUND,KLF3,LGALS1,MAF,MMP2,MYH7,NFKBIA,NINJ1,NOTCH2,OCLN,PALD1,PDE3B,PDPN,PEA15,PLS3,PMEPA1,PPARG,PTGS2,PTPN6,REL,RIPK2,RND3,SDC4,SERPINE1,SERPINF1,SGK1,ST14,STAT1,STAT6,Tcf7,TGFB1,THBS1,TLR4,TLR7,TNC,TNFRSF10A,TNFRSF1B,TNFSF8,UBC,UGCG,VCAM1,ZFP36 | 1244 (14) |
| MFAP5 | -1.36e+00 | other | NA | -4.10e-01 | NA | 0.0e+00 | ANGPT4,APLN,CDH1,CDH2,DUSP1,ECM1,ERBB3,ESPL1,F2R,FAM131C,GPX3,HSPE1,ITGB3,KIF11,KIF4A,MKI67,MRAS,MYLIP,NOTCH2,SPP1,TICAM2 | 783 (9) |
| Esrra | 7.60e-01 | transcription regulator | NA | -4.10e-01 | NA | 1.0e-02 | ACADL,ACSL5,AGL,ALDOA,ATP1A1,BDH1,BPGM,CNR1,COX6A2,ECH1,ENO2,ENO3,FABP1,GCGR,HGF,IDH3A,LEPR,OXCT1,PDK4,PGAM2,PGM1,PHKG1,PTGS2,PYGL,PYGM,RARA,Scd2,SLC2A1,SPP1,UQCR11 | 1119 (15) |
| FFAR3 | NA | G-protein coupled receptor | NA | -4.10e-01 | NA | 0.0e+00 | ANPEP,ARHGEF2,BCL11A,CALB1,CCL21,CD36,CXCL10,EYA1,FADS2,FCGR1A,FCGR2B,GBP2,GPD2,GPR183,ICAM1,KLF15,LOXL2,LY86,PITPNM3,PPARG,RASGRF2,RELN,SCN1B,SLC12A7,SMOC1,STAR,Tlr13,TLR7,TLR8,VAT1L,VSNL1 | 694 (8) |
| mir-27 | NA | microRNA | NA | -4.10e-01 | NA | 4.0e-02 | ABCA1,CXCL12,EDN1,FOXO1,HOXA5,IGF1,MAP2K4,MET,MSTN,MYH7,MYOG,OCLN,PNPLA2,PNPLA3,PPARG,PTGS2,RUNX1,SMAD9,SREBF1 | NA |
| KDM8 | -1.00e-01 | enzyme | NA | -4.10e-01 | NA | 0.0e+00 | ALDOA,CTSK,ENO2,ENO3,ETV1,EZH2,FBP2,G6PD,GAPDH,GSR,HERPUD1,HS6ST2,IDH1,LSS,OSR2,PC,PDK4,PGAM2,PKIB,PKM,SLC2A1,STK3,WNT5A | 1018 (9) |
| isoprenaline | NA | chemical drug | NA | -4.10e-01 | NA | 1.0e-02 | ABLIM1,ACTA2,HBA1/HBA2,IER5,KBTBD8,KLF5,MAP1LC3B,NR4A1,NR4A2,NR4A3,PER1,PLK2,PNPLA2,SLC2A1,SNX10,TGFB1 | NA |
| PPP5C | 7.60e-01 | phosphatase | NA | -4.20e-01 | NA | 0.0e+00 | AHR,CCND1,CD36,CDKN1A,DUSP1,PLIN1,SGK1 | 1342 (20) |
| FBXO32 | 1.05e+00 | enzyme | NA | -4.20e-01 | NA | 0.0e+00 | ABCC4,ALDH1A3,AXIN2,BCAT2,BCL2L11,CCND2,CKMT1A/CKMT1B,CSRP2,EIF2AK3,ERP44,FGF9,GADD45A,GCLC,HERPUD1,HOOK1,HSPB7,IL1R1,ITGA3,KLF5,KRT19,LBP,LEF1,MYCN,MYH6,MYOCD,MYOG,NANS,PPP3CA,PRKCZ,PTGER3,PTGES,PTGIS,PTGS2,RAB27A,SERP1,STT3A,Tcf7,TFPI2 | 1271 (13) |
| oxophenylarsine | NA | chemical reagent | NA | -4.20e-01 | NA | 4.0e-02 | BCL2L11,CCR3,HIF1A,MET,SELE | NA |
| TP63 | 8.40e-01 | transcription regulator | NA | -4.20e-01 | NA | 0.0e+00 | A2M,ABCC5,ACTA2,ADAMTS1,ADAMTS9,ADH7,ADRM1,AEN,AHR,ALDH1A3,ALOX12,APOBEC1,ARG1,AXL,BCL2L1,BCL2L11,BCL3,BCL6,BDKRB2,BHLHE40,BMP3,BMP4,CASP1,CASP3,CAV1,CCNA2,CCND1,CCND2,CCR1,CDH1,CDH2,CDH3,CDK17,CDK18,CDK6,CDKN1A,CEACAM1,CGN,CITED2,CLDN3,COL11A1,COL14A1,COL5A1,COL6A3,COL8A1,CRYAB,CXCR4,CYGB,CYP26B1,DCN,DDAH1,DDIT4,DKK3,DLL1,DNAJB1,DUSP10,DUSP6,ECM1,EDN1,EGR1,EGR2,ELN,EMP1,ENG,ERBB3,F2R,F3,FANCA,FBN1,FLRT1,FN1,FOXO3,FSCN1,FUBP1,FZD5,G6PD,GADD45A,GAPDH,GNAI1,GPNMB,GPX3,GREM1,HAS3,HGF,HIP1R,HRAS,HSP90AA1,HSPA1A/HSPA1B,ICAM1,IER3,IGFBP6,IGFBP7,IKBKE,IL17A,INHBA,IRF4,IRF5,ITGA2,ITGA3,ITGA4,ITGA6,ITGB4,JAG1,JAK3,KCNK1,KHK,KIF23,KLF4,KLF6,L1CAM,LAMA3,LAMC2,LYN,MAFF,MAP9,MKI67,MMP14,MMP2,MPZL2,MRAS,MRPL41,MYNN,NCS1,NID1,PARD6G,PCBP4,PIK3R3,Pmaip1,PNPT1,PRKCZ,PTGS2,PTPN12,RAC2,RASAL3,RASGRF1,RASGRP1,RASSF2,RASSF4,RASSF9,REL,RELN,RUNX1,RUNX2,S100A4,SELENOP,SERPINE1,SERPINF1,SLC41A2,SMAD6,SMAD7,SNAI1,SNAI2,SPON1,SSPN,STMN1,TACC3,TAGLN,TGFB1,THBS1,THBS2,THY1,TINAGL1,TMTC3,TNC,TNFAIP8,TNFRSF10A,TOP2A,TP63,TPO,TWIST1,UHRF1,VIM,WEE1,WNT4,WNT5A,ZEB2,ZNF212 | 1348 (19) |
| ketorolac | NA | chemical drug | NA | -4.20e-01 | NA | 5.0e-02 | Ccl2,HIF1A,NFKBIA,PTGS2 | NA |
| Hdac | NA | group | NA | -4.30e-01 | NA | 0.0e+00 | ADAMTS1,AHR,ATF3,BCL2L1,BCL6,BDNF,CCND1,CDKN1A,CSF1R,CSF2RA,CX3CL1,CXCR4,DKK3,DLL1,EDN1,EDN3,EDNRB,EGR1,EGR3,EMX2,EYA1,EZH2,FBXO32,GAD1,GADD45B,GLI2,HIF1A,HLA-DRA,IGF1,ITGA8,KCNH2,KLF10,KLF6,KLF9,MEOX1,MEOX2,mir-133,MMP14,MYCN,MYOD1,NDRG4,NOTCH4,NR4A1,NRP1,OSR1,PREX1,RGS10,ROBO2,SEMA3C,SFRP1,SFRP2,SMARCD3,SMO,SMPD3,SPP1,TBX3,TFAP2B,THBS4,TP63,TRPC6,WNT4,ZEB2 | 1547 (19) |
| AKT3 | -5.80e-01 | kinase | NA | -4.30e-01 | NA | 1.0e-02 | BCL2L11,COX4I1,ERBB3,ETS1,FOXO1,HSPE1,IL17A,RELN,SEMA6D,SOX10,WNK1 | 1485 (25) |
| dimethyl itaconate | NA | chemical reagent | NA | -4.30e-01 | NA | 3.0e-02 | ATF3,EIF2AK3,GCLC,IFITM3,IRF1,ISG15,NFE2L2,PRDX1,RSAD2 | NA |
| Raf | NA | group | NA | -4.30e-01 | NA | 0.0e+00 | ANPEP,BCL2L11,CCND1,CDKN1A,DUSP6,EDN1,EGF,EGR1,ETV1,ETV5,HAS2,ID2,IER3,IFI16,MAFF,MANSC1,PLPP3,RET,RND3,SEMA3C,SLC20A1,SPRED2,SPRY4,TAGLN,TOP2A,TPO | 1480 (20) |
| loxoribine | NA | chemical drug | NA | -4.30e-01 | NA | 2.0e-02 | PTGES,PTGS2,SDC1,TLR4,TLR5,TLR7 | NA |
| FSHR | NA | G-protein coupled receptor | NA | -4.30e-01 | NA | 4.0e-02 | ADIPOQ,CX3CL1,DUSP1,GATA4,GZMB,INHA,INHBA,INHBB,KITLG,MEDAG,MSI1,NPR3,PLA1A,PLAT,STAR | NA |
| OLIG2 | -4.70e-01 | transcription regulator | NA | -4.30e-01 | NA | 0.0e+00 | CHD7,DTX1,GFAP,MYRF,S100B,SOX10,ZEB2 | NA |
| HAND2 | -7.80e-01 | transcription regulator | NA | -4.30e-01 | NA | 0.0e+00 | ACTA1,ACTC1,ACTN2,ATP2A2,CASQ2,CCBE1,Ccl6,COL1A1,COL3A1,CXCR4,ECM2,FAP,GJA5,GREM1,HSPB7,MYH6,PHKA1,PLA2G2A,PTGS2,PTPRB,S100A4,TNNC1,TNNT2 | NA |
| TOX | -1.05e+00 | transcription regulator | NA | -4.40e-01 | NA | 0.0e+00 | AHR,CD244,EGR3,ENTPD1,FOXO1,ID2,LEF1,NFIL3,PRDM1,Tcf7,TNFRSF8,ZBTB7B | NA |
| PDGFA | 1.40e-01 | growth factor | NA | -4.40e-01 | bias | 2.0e-02 | EGR1,ELN,FGF10,FGF2,PROM1 | NA |
| SIX1 | -1.49e+00 | transcription regulator | NA | -4.40e-01 | NA | 0.0e+00 | ABLIM1,ACSL1,ACTA1,ACTC1,ACTN2,AK1,ALDOA,ANKRD2,ATP2A1,BHLHE40,BMP4,CACNG1,CASQ2,CD36,CDH1,CHRNA1,CKM,COL6A3,CRYAB,CSRP3,DACH1,DMPK,ENC1,ERBB3,FGF10,FN1,GPX3,KCNH2,KLF5,L1CAM,MAPRE3,MRAS,MYBPH,MYF5,MYF6,MYH2,MYH3,MYL1,MYOD1,MYOG,MYOM2,MYOM3,MYOZ1,NCAM1,PVALB,RYR1,SGCA,SIRT2,SIX2,TAGLN,TNNC1,TNNC2,TNNI1,TNNI2,TNNT1,TNNT2,TWIST2,VEGFC | 957 (15) |
| SNAI2 | -1.84e+00 | transcription regulator | NA | -4.50e-01 | NA | 0.0e+00 | ANKRD1,AXL,BCL2L11,BRCA2,CCND1,CDH1,CDH2,CDH3,CDKN1A,CLDN1,COL1A1,COL2A1,CXCL12,CXCR4,EGR2,FN1,ID4,ITGA3,ITGB4,L1CAM,MMP14,MYBPH,MYH3,MYH7,MYOD1,MYOG,MYOM3,OCLN,OLR1,PROM1,RUNX2,SNAI2,SOX10,TNNC1,TNNC2,TNNI1,TNNT2,TP63,TWIST2,UBE2D3,VIM | 1079 (22) |
| sesaminol | NA | chemical - endogenous non-mammalian | NA | -4.50e-01 | NA | 0.0e+00 | CKM,Cox8b,MB,MYBPC1,MYBPC2,MYH2,MYH7,MYL2,MYL3,MYLK2,MYO1D,MYOD1,MYOM2,MYOZ1,PVALB,TNNC2,TNNI1,TNNI2,Tpm1,TRIM63 | NA |
| ZFHX3 | 1.20e-01 | transcription regulator | NA | -4.50e-01 | NA | 0.0e+00 | CCND1,CDC14A,CREB3L1,DOHH,EBF1,F2RL1,HLA-A,HRAS,ID2,IFITM3,LRRC17,MYF6,MYH2,MYH7,MYOD1,MYOG,NDUFS7,NPR1,PLA2G7,PTGER3,PYGM,RGS2,RORB,SIM1,TUBA1A,Ubb,UQCR10,VIPR2 | 335 (6) |
| gingerenone A | NA | chemical - endogenous non-mammalian | NA | -4.50e-01 | bias | 0.0e+00 | ANKRD1,CDKN1A,EDN1,SERPINE1,TAGLN | NA |
| UBR2 | 3.60e-01 | enzyme | NA | -4.50e-01 | NA | 0.0e+00 | ADRB2,DACH1,LCP1,NEFL,PSMD9,SLC16A7 | NA |
| SND1 | 4.60e-01 | enzyme | NA | -4.50e-01 | NA | 0.0e+00 | CDH1,CDH2,CLDN1,EMP1,ETV1,JAG1,LTBP1,NR2F1,PTGS2,QPCT,SLCO4A1,SNAI2,VIM | 558 (7) |
| mir-190 | NA | microRNA | NA | -4.50e-01 | NA | 0.0e+00 | CCND1,CDH1,CLDN1,SNAI1,VIM | 1261 (12) |
| UBR1 | 1.00e-01 | enzyme | NA | -4.50e-01 | NA | 0.0e+00 | ADRB2,DACH1,LCP1,NEFL,SLC16A7 | NA |
| ACTA2 | -1.51e+00 | other | NA | -4.50e-01 | NA | 0.0e+00 | ACTA1,ACTA2,CDH1,MET,VIM | NA |
| RHOC | -1.00e-02 | enzyme | NA | -4.50e-01 | NA | 0.0e+00 | ATF3,CDKN1A,GLUL,NAT8L,RHOA | 820 (13) |
| D-alpha-hydroxyglutarate | NA | chemical - endogenous mammalian | NA | -4.50e-01 | NA | 1.0e-02 | GLI1,LDHB,PTCH1,RUNX2,SCD5 | NA |
| RSPO3 | -2.30e+00 | kinase | NA | -4.50e-01 | NA | 2.0e-02 | AXIN2,GLI1,MYF5,PTGS2,WNT4 | NA |
| gamma-secretase inhibitor XX | NA | chemical reagent | NA | -4.50e-01 | bias | 2.0e-02 | FBXO32,HEY2,JAG1,NOTCH4,TRIM63 | NA |
| PBRM1 | 2.00e-01 | other | NA | -4.50e-01 | NA | 3.0e-02 | CDKN1A,CENPF,CXCL10,FOXP3,IGFBP4,PLK1,S100A13 | NA |
| NELFB | 4.50e-01 | other | NA | -4.50e-01 | NA | 4.0e-02 | ATF3,CDKN1A,GADD45A,GADD45B,RPS3 | NA |
| CST3 | -5.20e-01 | other | NA | -4.50e-01 | NA | 4.0e-02 | CALCR,CTSK,FGF2,IRF8,NFKBIA | NA |
| CCAT1 | NA | other | NA | -4.50e-01 | NA | 4.0e-02 | CASP3,CDH1,CDH2,CDKN1A,VIM | NA |
| BEX2 | NA | other | NA | -4.50e-01 | NA | 4.0e-02 | CDH2,MAP2,MMP2,SPP1,SWAP70 | NA |
| clorgyline | NA | chemical drug | NA | -4.50e-01 | NA | 4.0e-02 | CASP3,CEBPD,GNAS,HIF1A,SOCS3 | NA |
| SR 144528 | NA | chemical reagent | NA | -4.50e-01 | NA | 4.0e-02 | CCR1,EGR1,ICAM1,IL1RN,NFKBIA | NA |
| erlotinib | NA | chemical drug | NA | -4.50e-01 | NA | 0.0e+00 | ADAM17,AXL,BCL2L1,BCL2L11,CAMLG,CD36,CERS4,COL8A1,CYBB,EGR1,ENAH,F3,FAP,FBN1,FGF2,FN1,ICAM1,IGFBP4,IGFBP6,IGFBP7,IKBKB,MME,MMP14,NFKBIA,NOX1,NOX4,OCLN,PDGFB,SERPINE1,SNAI1,SNAI2,TAB3,TGFA,TLR2,TLR4,TLR5,TNFRSF10A,TNFRSF11B,TNFRSF1B,TRADD,TSPAN8,TYMS | 1607 (18) |
| CRH | -1.10e-01 | cytokine | NA | -4.50e-01 | NA | 0.0e+00 | AQP4,ARG1,BDKRB2,BDNF,CCNA2,CLEC11A,EDN1,IL1RN,IL2RA,MRC1,NOS1,NR4A1,PNMT,PRKCE,PTGS2,SGK1,SLC2A1,SOCS3,STAR,TLR4,TPH1,UCN | 1182 (21) |
| MC1R | NA | G-protein coupled receptor | NA | -4.60e-01 | NA | 1.0e-02 | MITF,NR4A1,NR4A2,NR4A3,SDC2 | 1450 (18) |
| LIN28B | 2.20e-01 | other | NA | -4.60e-01 | NA | 0.0e+00 | AXIN2,BCL11A,CCND2,CD44,CDH1,CDH2,CDKN1A,COL2A1,GCNT2,ITGB4,LGR5,MMP14,MYCN,PROM1,SCX,SNAI1,SREBF1,TWIST1,VIM,ZBTB20,ZEB2 | 594 (7) |
| methotrexate | NA | chemical drug | NA | -4.60e-01 | NA | 0.0e+00 | ABCA1,ACTG1,ADORA2A,AK4,ALDOA,ALOX12,AMD1,AUH,BDNF,BTG2,C1R,C2,C3,C4BPA,C6,CASP3,CCL21,CCND1,CD28,CDH1,CDKN1A,CFB,CFH,CFI,CLEC11A,CRP,CSF1,CSF1R,CTSS,CXCL10,CXCL12,DUSP1,DUSP10,ECH1,ENO3,FA2H,FABP1,FADS1,FAR1,GAP43,GAPDH,GPAM,GPI,GSR,HBA1/HBA2,HSD17B4,ICAM1,IGFBP5,IL17A,ITGA1,LBP,LPIN1,LPL,MAPK14,MET,MITF,Mt1,NR4A2,NXN,OCLN,PECR,PLD2,PPARD,PPIA,PRDX1,PRKCB,PTGS2,RPS6KB1,S100A11,SELENOP,SERPING1,SOCS3,SPP1,STAT5B,TEF,TGFB1,THBS1,TNFRSF11B,TYMS,VCAM1,ZFP36L1 | 1323 (17) |
| ADAM10 | -8.10e-01 | peptidase | NA | -4.60e-01 | NA | 0.0e+00 | ACTA2,ADAM10,ATP2A2,ATP6V0A4,ATRX,C3,CALCRL,CAMK2A,CCND1,CD74,CDH2,CRYAB,CSF1,CXCL12,CXCL16,EFNA5,GADD45G,GNA13,IDH3A,IFI16,INHBA,INHBC,ITGA5,KLC2,MET,MYO15A,MYO7A,MYOG,NOS1,PARK7,PEA15,PLP1,PVALB,Pzp,RGS4,ROCK1,RPS10,SYP,TGFB1,TWF2,YWHAQ | 1460 (22) |
| IFNGR1 | -1.70e-01 | transmembrane receptor | NA | -4.70e-01 | NA | 0.0e+00 | A3GALT2,BCL6,Bmyc,BTRC,CA9,CCDC124,Ccl2,Ccl7,COL1A1,COL3A1,CTSS,CXCL10,CXCL12,ECH1,EGF,EGR1,FHL3,FN1,FSCN1,GATA4,GBP5,HCK,ICAM1,IFITM3,IL17A,IRF1,LBX1,LDHB,MID1,MITF,MMP2,MX1,MYH7,NAB2,Naip1 (includes others),NLRC4,NLRP3,NNMT,PLTP,PNPLA7,PRKAB1,RNF7,SMYD2,ST6GAL1,TCEAL7,TMEM259,TRPM4,TTLL11,UBAC1,UBC,Zfp429 (includes others) | 1113 (16) |
| F Actin | NA | complex | NA | -4.70e-01 | NA | 1.0e-02 | CD86,CTSS,FLNA,MMP2 | 1058 (10) |
| plumbagin | NA | chemical drug | NA | -4.70e-01 | NA | 2.0e-02 | BCL2A1,BCL2L1,BIRC3,CCND1,CYBB,PRKCE,PTGS2,PTPN6,TNFRSF10A | NA |
| PDK1 | -1.40e-01 | kinase | NA | -4.70e-01 | NA | 2.0e-02 | ADIPOQ,CARD11,CCNA2,CDH1,CXCR5,FOXO1,HDAC9,HIF1A,MAP3K14,PIK3R1,PIK3R3,PLK1,PRKCQ,PRKCZ,RIPK2,SELP,SLAMF1,VIM | NA |
| ANXA7 | -3.50e-01 | ion channel | NA | -4.70e-01 | NA | 3.0e-02 | ALOX15,BRCA2,CDH2,DAD1,ELF1,EPHB2,FGF9,FYN,GSR,HGF,IGF1,IGHMBP2,ITGA2,MGST1,PHLDA1,SLA,TEK,TNFRSF1B | NA |
| STAT5A | -4.00e-02 | transcription regulator | NA | -4.70e-01 | NA | 0.0e+00 | A2M,ABCA1,ABCG1,ADIPOQ,ARID3B,AXIN2,BCL11A,BCL2A1,BCL2L1,BCL6,BIRC3,C15orf48,CASP3,CASP8,Ccl2,CCND1,CCND2,CCR5,CDH1,CDK6,CDKN1A,CEACAM1,CISH,CYP1B1,DUSP5,EZH2,FCER1G,GADD45A,GADD45G,H2AC18/H2AC19,ICAM1,ID2,IGF1,IGFALS,IL2RA,IL2RB,IRF1,KIT,KLF10,Klrc2/Klrc3,LEF1,MAF,MAL2,MAP1LC3A,MYH7,MYL2,NNT,NR4A2,OLR1,PBX3,PPARG,PRDM1,PROM2,QPCT,QPRT,RUNX2,SBSPON,SELENBP1,SLC2A1,SLC2A10,SLC7A8,SNTB1,SOCS1,SOCS3,SREBF1,STAT5B,SYTL2,TGFBI,TICAM2,TM4SF1,TNFRSF25,TNFRSF4,TNNC1,TNNI1,TNNT1,TSPAN8,ZFP36 | 1550 (19) |
| CIP2A | NA | other | NA | -4.70e-01 | NA | 0.0e+00 | ACTG2,C4BPA,CFB,COL8A1,CRYAB,DCN,E2F2,ENO3,FAP,GADD45A,GPNMB,GPR183,IER3,LASP1,LDHB,LUM,MFAP5,PDK4,PDLIM7,PKM,PTPRB,PXYLP1,RAB31,SLC16A3,SNCA | 1134 (7) |
| Immunoglobulin | NA | complex | NA | -4.80e-01 | NA | 0.0e+00 | ABCA7,ACKR2,ACO2,ACSL1,ACTA1,ACTA2,ADAM10,ADAM17,ADAM19,ADAMTS2,ADAMTS5,ADCY4,ADGRE1,ADRB2,AGPAT2,AHR,AIF1,ALDOA,ANGPT2,ANPEP,ANTXR1,APLN,APLNR,AQP4,ARG1,AXL,B2M,BATF,BCAT1,BCL2A1,BCL2L1,BCL2L11,BCL3,BCL6,BDNF,BIN1,BIRC3,BLVRB,BMP4,BMP5,BPGM,BTK,C3,C3AR1,C5AR1,C6,CAMK2D,CASP1,CASP3,Ccl2,Ccl7,CCNA2,CCND1,CCND2,CD1D,CD276,CD28,CD300LF,CD34,CD44,CD74,CD83,CD86,CD9,CD93,CDH1,CDH2,CDK2,CDK6,CEBPD,CIITA,CISH,CMA1,COL1A1,COL3A1,COL5A2,COL6A3,COX6A2,COX6B1,CSF1,CSF1R,CSF2RB,CST7,CTHRC1,CTSH,CTSS,CX3CR1,CXCL10,CXCL12,CXCL13,CXCL16,CXCR4,CXCR5,CYBA,CYP1B1,CYSLTR1,DDIT4,DPYSL2,DTX1,DUSP1,DUSP6,EDNRB,EGLN1,EGR1,EGR2,EGR3,EIF2AK3,ELN,ENG,ENO2,ENO3,ENPP3,ENTPD1,ESM1,ETV5,EXT1,EZH2,F13A1,F3,FADS2,FAM107A,FAP,FBN1,FBP2,FCER1G,FCGR1A,FCGR3A/FCGR3B,FGF1,FGL2,FKBP5,FN1,FOXO1,FOXO3,FOXP3,FYN,G6PD,GAS7,GBE1,GBP5,GFAP,GLI1,GLUL,GPI,GPNMB,GPR34,GPSM1,GPT2,GPX3,GSK3A,GSR,GZMB,H2-T24,HCK,HEY2,HIF1A,HLA-A,HLA-DQA1,HLA-DRA,ICAM1,IDH3A,IER3,IFI16,IFIT1,IFITM3,IGF1,IGFBP4,IKZF2,IL10RA,IL10RB,IL15RA,IL17A,IL18R1,IL1R1,IL1RN,IL2RA,IL2RB,IL2RG,IL33,INHBA,INPP5D,IRF1,IRF3,IRF4,IRF5,IRF8,ISG15,ITGA4,ITGAE,ITGB2,KDR,KLF4,LGALS1,LILRB3,LOX,LPL,LTB4R,MAF,MAFF,MAP1LC3B,MAP3K14,MDH1,MICAL2,MKI67,MMP14,MMP15,MMP19,MMP2,MOV10,MOXD1,MS4A6A,MSS51,MTHFD2,MX1,Naip1 (includes others),NCEH1,NCF2,NDUFA1,NDUFA7,NDUFB3,NDUFS7,NEB,NFAT5,NFE2L2,NFIL3,NFKBIA,NLRC4,NLRP3,NOS1,NOTCH2,NR4A1,NRP1,OAS3,OASL,OCLN,OLFML3,OLR1,OPALIN,OSBPL3,OTOG,P2RY12,P3H4,PARP14,PC,PCOLCE,PCOLCE2,PDE3B,PDK4,PDLIM4,PENK,PGAM2,PGK1,PGM1,PHKB,PHKG1,PIK3R1,PLCG2,PLEK,PLIN4,PLK3,PNPLA2,POU2F2,PRDM1,PRDX1,PRDX5,PROS1,PRPS2,PTAFR,PTGS2,PTPRC,PTX3,PYCARD,PYGM,RAB31,RAC2,REL,RGS2,RNF128,RPS11,RPS3,RSAD2,RUNX2,Scd2,SDC1,SELE,SELP,SFRP2,SIRPA,SLC25A43,SLC27A1,SLC2A1,SLC35C2,SLC39A6,SLC41A2,SLC6A9,SLCO2B1,SLFN13,SMOX,SOAT1,SOCS1,SOCS3,SPHK1,SPP1,ST6GAL1,STAT1,STMN1,TGFB1,THBD,THBS2,THY1,TIMP1,TLR2,TLR7,TLR8,TM2D2,TMEM106B,TNFAIP2,TNFRSF11B,TNFRSF1B,TNFRSF4,TNFRSF8,TNFSF8,TNMD,TRADD,TRPV1,USP18,USP19,VCAM1,VCAN,VSIR,WLS,ZBTB16,ZEB2,ZFP36L2 | 1425 (16) |
| PIK3CA | -5.00e-01 | kinase | NA | -4.80e-01 | NA | 0.0e+00 | ADAMTS1,ADAMTS5,ALCAM,ANK1,ATP1A1,BIRC3,CA9,CCDC8,Ccl2,CCND1,CD44,CDH1,CDH11,CDH2,CEBPD,CLDN1,COL5A1,CXCL12,CXCL13,CXCR4,ELMO1,EPN3,EZH2,F2RL1,F3,GPR68,GSR,HIF1A,HNRNPC,IL33,IP6K2,IRS1,IRS2,JAG1,KDR,LEF1,LMO2,LOX,LUM,MCTP1,MFAP5,NDRG4,NFKBIA,NUAK2,PALM,PCDH7,PDGFB,PDGFRA,PIK3CG,PTGS2,PTX3,RUNX1T1,SERPINE1,SLIT3,SNAI1,SNAI2,SPARC,SREBF1,SRP68,TGFB1,THBD,THY1,TP63,TWIST1,TWIST2,VIM | 1446 (19) |
| PTTG1 | -3.40e-01 | transcription regulator | NA | -4.80e-01 | NA | 4.0e-02 | ATRX,CCNA2,CCND1,CD44,CDH1,CDH2,CDKN1A,CEBPD,EGF,ERCC1,FEN1,FGF2,HIF1A,IGF1,MBD4,NTHL1,SNAI1,TGFA,VIM,XPA | NA |
| N-Ac-Leu-Leu-norleucinal | NA | chemical - protease inhibitor | NA | -4.80e-01 | NA | 0.0e+00 | ABCA1,ABCA7,BCAR1,BCL2L1,BCL2L11,CASP3,CAV1,CCND1,CDKN1A,COBL,CREB1,HLA-A,ICAM1,IER3,KCNH2,LAMP2,MYCN,MYOG,NEDD9,NFKBIA,PAWR,PRKCE,PTGS2,RARG,RBL1,RUNX2,Scd2,SELP,SREBF1,STMN1,SYK,USF2 | 1603 (18) |
| ZMPSTE24 | -4.60e-01 | peptidase | NA | -4.90e-01 | NA | 0.0e+00 | ATF3,BTG2,CASP1,Ccl6,CDKN1A,CISH,CXCL14,DDIT4,DIO1,Esrra,FMO2,GADD45A,GADD45B,GADD45G,ICAM1,IGF1,IGFALS,IGFBP5,NLRP3,SESN1,SIRPA,SOCS1,SOCS3,STAT5B | 1400 (18) |
| calcium chloride | NA | chemical drug | NA | -4.90e-01 | bias | 2.0e-02 | CD1D,MMP2,NR4A1,S100A4,TNFRSF11B | NA |
| apomorphine | NA | chemical drug | NA | -4.90e-01 | NA | 1.0e-02 | ADORA2A,BCL2L1,BDNF,CACNB3,EGR1,FGF2,HOMER1,PDIA4,PTN,SYT3 | NA |
| GATA4 | -1.46e+00 | transcription regulator | NA | -4.90e-01 | NA | 0.0e+00 | ACTA1,ACTC1,ACTG2,ACTN2,ANGPT4,ANKRD1,ATP2A2,BCL2L1,CA12,CASQ2,CCBE1,Ccl6,CDC42EP3,CLDN1,COL1A1,COL3A1,COX6A2,CTHRC1,CXCR4,DAB2,ECM2,EDN1,EMX2,EPHX1,ESPL1,FABP1,FAP,FGF16,FGF2,FRZB,GATA4,GJA5,GPI,HK1,HSPB7,IFI16,IGFBP5,IGFBP6,INHA,INHBA,INHBB,IRF6,IRF8,KCNA5,KIT,LRG1,LTBP2,MC2R,MYBPC3,MYH6,MYH7,MYL1,MYL2,MYOG,NOTCH4,NR5A1,NR5A2,OGN,PHKA1,PLA2G2A,PLIN4,PRDM1,PTGS2,PTPRB,S100A4,SCN5A,SFRP4,SLC9A3,SPP1,STAR,TAGLN,TAL1,TGFBI,THBS4,TIMP1,TNNC1,TNNT2,VCAM1,VIM | 827 (14) |
| VEGFB | 3.10e-01 | growth factor | NA | -4.90e-01 | NA | 0.0e+00 | ACTA1,ATF3,ATP2A2,BCL2L11,Casp12,CASP8,DCN,GSR,HACD2,IRF4,MSS51,MYH6,MYH7,OLR1,PDK4,Pmaip1,PRDX1,PRDX5,SLC27A1,SLC27A3,TXNRD3 | 785 (11) |
| bisphenol A | NA | chemical - endogenous mammalian | NA | -5.00e-01 | NA | 1.0e-02 | ADIPOQ,ARNT2,C3,CASP3,CCND1,CD36,CDH1,CDKN1A,CITED2,COL1A1,COL5A1,CXCL10,CXCL12,EGR1,ELN,FGF1,FGF9,GAD1,GLO1,HSPA1A/HSPA1B,IGF1,IKBKB,KDR,KIT,LBP,LCP2,MET,NR4A1,NR4A2,NR4A3,OCLN,PER1,PFKFB4,PPARG,PTGS2,SCNN1G,SGK1,SLC1A5,SLC6A13,SLFN12,SMOC1,SRSF3,THBS1,TNC,TRA2A,TWF2,VCAN,WNK2 | 1549 (24) |
| pioglitazone | NA | chemical drug | NA | -5.00e-01 | NA | 0.0e+00 | ABCA1,ABCG1,ACTA1,ACTA2,ADIPOQ,AQP7,ATP2A2,CASP3,CAV1,Ccl2,CCND1,CD36,CD86,CDKN1A,CEBPD,CITED2,CKM,CMKLR1,COX4I1,CXCL10,EGR1,FBP2,FN1,FOXP3,GFAP,HAS2,ICAM1,IL17A,IL1RN,IRS1,IRS2,KLF4,KRT19,LEPR,LPIN1,LPL,mir-143,NCEH1,NCF1,NCF2,NOX1,NR4A1,NR4A3,PC,PDE3B,PLIN1,PPARD,PPARG,PPARGC1B,PTGS2,RETN,SCNN1G,SERPINE1,SLC27A1,SLC2A1,SLC9A3,SOAT1,SREBF1,STAT5B,TGFB1,TNFRSF1B,UCP3 | 1506 (22) |
| MEX3A | -4.10e-01 | other | NA | -5.00e-01 | NA | 0.0e+00 | ABCA1,ACADL,AGPAT2,AQP7,CCND1,CD36,CD44,CYP27A1,FZD2,NRP1,PDK4,PLK1,PPARG,PRELP,SFRP5,TUBA1A | NA |
| ALK | -7.20e-01 | kinase | NA | -5.10e-01 | NA | 0.0e+00 | BCL2L1,CCND2,CDH1,CDH2,COL3A1,EFS,EGR2,EGR3,ENO2,FOXP3,GLI1,GNB4,HOMER3,ID4,MYCN,NID1,NTRK2,PITX2,S100A11,SERPINE1,SNAI1,SNAI2,STMN4,TCEAL7,TMOD1,TNFRSF8,USP18,WIPF1 | 1141 (19) |
| CCNC | -2.80e-01 | other | NA | -5.10e-01 | NA | 1.0e-02 | ADIPOQ,CD36,Cox8b,LPL,PLIN1,PNPLA2,PPARG,SREBF1,TYMS,VCAM1 | 1177 (12) |
| SATB1 | -2.00e-01 | transcription regulator | NA | -5.10e-01 | NA | 0.0e+00 | ABTB1,ACTG1,BCL2A1,BORCS6,CCND1,CD86,CDH1,CDKN1A,CEACAM1,CSF3R,CYBB,EPSTI1,ETS1,EVI2A,F5,FCGR1A,Foxp1,FOXP3,GADD45B,GLRX,GPT2,HLA-DOB,HSP90AA1,HVCN1,IL10RA,IL16,IL2RA,IL7,IRF8,KITLG,MAF,MAFA,MAL,NFE2L2,NR4A2,PRKCB,PTGS2,RASGRP2,RUNX1,SGK1,TGFA,TMEM241,TNFRSF8,UBE2L6,UHRF1,VIM,VPS37B | 1419 (17) |
| F7 | 4.00e-02 | peptidase | NA | -5.10e-01 | NA | 0.0e+00 | Ccl2,CCND1,CLDN1,EEF1A1,EGR1,F3,GADD45A,ICAM1,JAG1,KLF5,MMP14,PTGS2,RND3,VCAM1,ZFP36 | 873 (15) |
| MIR31HG | NA | other | NA | -5.10e-01 | NA | 2.0e-02 | CDKN1A,FGF2,HGF,HIF1A,IGFBP6,IGFBP7,SERPINE1,TIMP1,TNFRSF11B | NA |
| TET2 | -3.40e-01 | enzyme | NA | -5.20e-01 | NA | 0.0e+00 | ANXA2,APOBEC1,ASPA,BCL2L11,BCL3,BHLHE40,C5AR1,Ccl2,Ccl7,CHST11,CRB1,CSF1R,CYP2S1,ESRRB,FGL2,FN1,FOXC1,FOXP3,GATA4,GRK5,IFI16,IFITM3,IL1R1,ITGA2,ITGB2,MAFF,MTSS1,MYH6,MYH7,NAV1,PLS3,PXDC1,RND3,RNF144A,RSAD2,RUNX1,SGPP1,SLC20A1,SLC2A1,TBX5,TGFA,TIMP1,TNNT2,XYLT1,ZBTB16 | 1296 (17) |
| MGP | 1.10e-01 | other | NA | -5.20e-01 | NA | 0.0e+00 | ACTA2,CXCR4,GATA4,HGF,HHEX,IL15RA,ITGB7,JAG1,MAP3K14,MET,MYOCD,RUNX2,SPP1,TAGLN,TGFBI | 988 (17) |
| CDK6 | -7.20e-01 | kinase | NA | -5.30e-01 | NA | 0.0e+00 | ACTN2,ACVR1B,ADCY7,ATP2A1,AUH,BIRC3,BMP5,CA9,CACNB4,CASP8,CD36,CDK6,CDKN2C,CREB5,FMOD,FN1,FOXO3,GADD45A,GDF6,HRAS,INHBA,INPP5J,ITGA11,ITGA2,ITGB3,MGST2,MYH7,PIK3R3,PPP1R3B,PRKCB,PTGS2,PYGM,RASSF5,SERPINE1,SLC27A3,SLC8A3,SOCS1,SOCS3,TGFA | 1449 (22) |
| PTGS2 | -1.49e+00 | enzyme | NA | -5.30e-01 | NA | 0.0e+00 | AIF1,ANGPT2,ANXA1,ANXA2,ARG1,AXIN2,B2M,BCL2L1,BIRC3,C5AR1,Ccl2,CCND1,CD44,CD74,CDH1,CDKN1A,CDKN2C,CHKA,CIITA,CLEC12A,CTSK,CXCL10,CXCL12,CXCL14,CXCR4,CYBB,CYP1B1,DLK1,DUSP1,DYNLL1,EGR1,ERBB3,EZR,FCGR3A/FCGR3B,FCGRT,FN1,GATA4,HLA-A,HLA-DQA1,ICAM1,IGF1,ITGA6,ITGAL,ITGB4,KDR,LPL,LTBP1,MKI67,MMP14,MMP2,MRC1,MSR1,NEB,NFE2L2,NKD1,NKD2,NOP2,NR4A2,NTN1,PCDH7,PIK3CG,PLA2G4A,PPARG,PRKCZ,PTGER1,PTGER3,PTGS2,PYCARD,RETN,RHOA,RUNX2,SEMA7A,SIGLEC10,SNAI1,ST3GAL1,STAR,STAT5B,TEK,TGFB1,TNFAIP6,VEGFC | 1168 (15) |
| SH42 | NA | chemical reagent | NA | -5.40e-01 | NA | 0.0e+00 | ARG1,CD36,CMKLR1,HRAS,PIK3R1,PIK3R3,PRKCB,PRKCD,PRKCE,PRKCQ,PRKCZ,RHOA,RPS6KB1,STAT1 | 1374 (19) |
| methylphenidate | NA | chemical drug | NA | -5.40e-01 | NA | 0.0e+00 | BCL9,BDNF,CD93,DAPK3,DHRS1,EGR1,GCH1,GFAP,HOMER1,HOMER2,KLHDC3,NCAM1,NECTIN1,PKN1,SLC18A2,TSPAN2,UBE3D,WHAMM | 924 (7) |
| potassium chloride | NA | chemical drug | NA | -5.40e-01 | NA | 0.0e+00 | AATK,AMIGO2,ATF3,ATP1A1,ATP1B1,ATP2B3,ATP2B4,BCL2L11,BDNF,BTG2,CALB1,CASP3,Ccl2,COL1A1,COL3A1,EGR1,EGR2,EIF2AK3,FGF10,FGF9,HERPUD1,IGF1,IGFBP5,MYOCD,NOS1,NR4A1,NR4A2,NR4A3,NTRK2,PDIA4,PIK3R1,PIM3,PTGS2,SLC7A1,SLC8A3,SLC9A1,SPP1,UNC5B | 1516 (20) |
| DETA-NONOate | NA | chemical reagent | NA | -5.40e-01 | NA | 0.0e+00 | ACTA2,ADAM10,ASAH2,BCL2L1,BGN,BIRC3,CA9,CAV1,CCND1,CDKN1A,CNN1,DUSP1,GLO1,HIF1A,ICAM1,LOXL2,PDE3B,PTGS2,SERPINE1,STAR,TAGLN2,TIMP1,TNFRSF11B,VCAM1 | 1182 (15) |
| RAB2A | 9.90e-01 | enzyme | NA | -5.50e-01 | bias | 2.0e-02 | ACSL1,CD36,FABP1,PLIN3,PLIN4,PPARG,SREBF1 | NA |
| DUSP10 | -2.20e+00 | phosphatase | NA | -5.50e-01 | NA | 0.0e+00 | ACTA2,ARG1,CHI3L1,COL1A1,COL3A1,FN1,KLF5,MRC1,SMAD7 | 1574 (21) |
| 7(R)-maresin 1 | NA | chemical - endogenous mammalian | NA | -5.50e-01 | NA | 0.0e+00 | ACTA2,ALOX12,ALOX15,ARG1,ATP2A2,Ccl2,IRF5,PDPN,STAT1,TGFB1,TLR4 | 1052 (15) |
| ITGA3 | -6.00e-01 | other | NA | -5.60e-01 | NA | 0.0e+00 | DAB1,FN1,ITGA2,MMP2,PTGS2,RHOA,SERPINE1 | 1363 (21) |
| CUL4B | -1.30e-01 | other | NA | -5.60e-01 | NA | 1.0e-02 | AXIN2,CDH1,CDK2,FANCB,FOXO3,GLO1,MCM8,NKD2,PYGO2,RNASEH1,RUNX1,SOCS1,TGFB1,UBXN1,ZFP36 | 533 (7) |
| LRRC32 | 2.00e-01 | other | NA | -5.60e-01 | NA | 2.0e-02 | CDH1,FOXP3,ITGAE,TGFB1,VIM | NA |
| NEK2 | NA | kinase | NA | -5.60e-01 | NA | 2.0e-02 | BCL2L1,CDH1,CDKN1A,GADD45A,MYO18A | NA |
| teriflunomide | NA | chemical drug | NA | -5.60e-01 | NA | 4.0e-02 | CASP8,FADD,ICAM1,IL10RA,TRPC6 | NA |
| ELN | -1.23e+00 | other | NA | -5.60e-01 | NA | 4.0e-02 | CD86,ELN,FN1,MMP2,NCF1 | NA |
| ZFPM2 | -1.42e+00 | transcription regulator | NA | -5.60e-01 | NA | 4.0e-02 | ATP2A2,DHH,KDR,MYH6,MYH7,WNT4 | NA |
| sulindac sulfide | NA | chemical drug | NA | -5.60e-01 | NA | 2.0e-02 | ALOX15,ATF3,BCL2L1,CCND1,CDKN1A,CYP1B1,DYNLL1,EGR1,GADD45A,GADD45G,KRT19,MSMO1,MTHFD2,MYOZ1,PIK3R1,PPARD,PTGES,PTGS2,RANBP1,RAP1GAP | NA |
| everolimus | NA | chemical drug | NA | -5.60e-01 | NA | 0.0e+00 | ABCA1,AXIN2,BCL2L1,CAV1,CCND1,CCND2,CDKN1A,FSCN1,KDR,LGR5,MMP2,NCEH1,NKD1,SLC2A1,SNAI1,SOAT1,XPA | 1085 (15) |
| H2AZ1 | NA | other | NA | -5.60e-01 | NA | 0.0e+00 | AGPAT2,CCND1,CDKN1A,CXCR4,E2F2,E2F8,HPSE,IGFBP5,MAPK4,MCM7,MKI67,MYOD1,NUP62,PLK1,PPARG,SPC25,TACC3,TOP2A | 599 (7) |
| ACKR3 | -8.40e-01 | G-protein coupled receptor | NA | -5.60e-01 | NA | 0.0e+00 | AXL,CCND1,CDKN1A,CFH,CXCL12,CXCR4,ELN,FMOD,IGFBP7,MMP14,STMN1,TNNC1,VWF | 1001 (17) |
| stearic acid | NA | chemical - endogenous mammalian | NA | -5.60e-01 | NA | 1.0e-02 | ATF3,BCL2L11,CYP4F2,EDN1,F2RL1,ICAM1,NFKBIA,PPARGC1B,PRKAA1,PTGS2,SNCA | NA |
| ZEB2 | -9.80e-01 | transcription regulator | NA | -5.70e-01 | NA | 0.0e+00 | AXL,CASP3,CCND1,CD7,CDH1,CDH2,CDK6,CDKN1A,CX3CR1,CXCR5,ESRP2,GATM,ID2,ID4,INPP5D,KRT19,MEOX2,MITF,MMP2,MS4A2,PLCG2,SFRP1,SNAI1,Tcf7,VCAM1,VIM | 1349 (20) |
| WNT3 | 1.00e-01 | other | NA | -5.70e-01 | NA | 0.0e+00 | CDKN1A,GLI1,GLI2,ITGA6,PTCH1,PTGS2,RUNX2 | 1448 (19) |
| heparin | NA | chemical - endogenous mammalian | NA | -5.70e-01 | NA | 0.0e+00 | ACADL,ACTA2,ARG1,CCND1,CD83,CD86,CNN1,COL1A1,DUSP1,EPHB2,F3,FN1,HAS2,HPSE,ICAM1,IL1R1,LPL,MMP14,MMP2,PLAT,RUNX2,SELP,SLC2A1,THBD,TNFAIP6,VCAM1,VIM | 1073 (14) |
| Smad | NA | complex | NA | -5.70e-01 | NA | 1.0e-02 | CDKN1A,COL1A1,EGLN1,GLI2,ID2,ID4,INPP5D,SERPINE1,SMAD7,WNT5A | 1267 (15) |
| SLC2A1 | -1.88e+00 | transporter | NA | -5.70e-01 | NA | 0.0e+00 | ALDH1A1,ALDH1L2,DHRS9,FN1,Gsta4,KLF4,MMP2,PTGS2,SERPINE1,SLC1A5,SLC2A1 | 1369 (22) |
| advanced glycation end-products | NA | chemical - endogenous mammalian | NA | -5.80e-01 | NA | 0.0e+00 | ABCA1,ABCG1,CASP3,CASP8,CDKN1A,CXCL12,DDAH2,F2R,FGF2,FN1,FOXO1,MKI67,PDGFB,PFN1,PPARG,PTGES,PTGS2,SERPINE1,SERPINF1,SPP1,TGFB1,TLR4,VCAM1 | 1360 (15) |
| C9 | -3.00e-02 | other | NA | -5.80e-01 | NA | 0.0e+00 | Ccl2,COL1A1,COL3A1,FN1,ICAM1,SELE,VCAM1 | 679 (9) |
| sodium orthovanadate | NA | chemical reagent | NA | -5.80e-01 | NA | 1.0e-02 | BCL2L1,CCNA2,CCND1,CDKN1A,COL1A1,HIF1A,IL2RA,MSR1,NFKBIA,SERPINE1,SLC2A5,STAR | 1388 (19) |
| EPHA2 | -3.50e-01 | kinase | NA | -5.80e-01 | NA | 0.0e+00 | ARRDC3,ATF3,CASP3,DUSP1,EDN1,EGR1,FGF2,HRAS,IER3,IL33,KLF6,MAPK3,NR4A1,SELE,SGK1,VCAM1,ZFP36 | 1430 (22) |
| DDX25 | -4.60e-01 | enzyme | NA | -5.80e-01 | NA | 1.0e-02 | ACSL1,AIF1,ASB9,ATP1B2,AZIN2,BCL2L1,CCND2,CHL1,CPEB3,DDR1,DNAJB4,DNAJB7,DPYSL3,EEF1D,GADD45B,GLUL,IL2RG,MPZL2,NFKBIA,PAQR5,PDE1A,PPP2R2B,REEP6,S100A10,Scd2,SKP2,SOCS7,STAR,TRIM36,UBE2G2 | NA |
| PML-RARA | NA | fusion gene/product | NA | -5.80e-01 | NA | 1.0e-02 | CDKN1A,CYTH4,EGR1,F3,FGR,JAG1,LEPR,MYO1F,RARA,RXRA,S100A10,VCAM1 | NA |
| ZFAS1 | NA | other | NA | -5.90e-01 | NA | 0.0e+00 | CDH1,CDH2,MMP14,NKD2,SKA1,VIM,ZEB2 | NA |
| FZD8 | -1.00e-02 | G-protein coupled receptor | NA | -5.90e-01 | NA | 0.0e+00 | ACTA2,BMP4,CDH1,COL1A1,FN1,GATA4,IGFBP5,MYH6,TBX5,VCAN,VIM | 1249 (14) |
| KDM4B | 6.80e-01 | enzyme | NA | -5.90e-01 | NA | 1.0e-02 | GAPDH,LOX,LOXL2,MDH1,PDGFB,PDK2,PGM1,PKM,VIM | NA |
| PTGES3 | -4.70e-01 | enzyme | NA | -5.90e-01 | NA | 5.0e-02 | ABCC3,HIF1A,PMP22,TM4SF1 | NA |
| vinorelbine | NA | chemical drug | NA | -6.00e-01 | NA | 0.0e+00 | B2M,BCL2L1,CD74,DTX1,FBXL2,LGALS1,RAC2,TYMS,ZFP36L2 | NA |
| NDST1 | -2.60e-01 | enzyme | NA | -6.00e-01 | NA | 1.0e-02 | CDH1,FGF2,FGF9,KDR,TGFB1 | 1527 (19) |
| FGF4 | NA | growth factor | NA | -6.00e-01 | NA | 4.0e-02 | Ccl2,CDKN1A,FOXO1,FOXO3,JAG1,MMP14,Scd2,SOSTDC1 | NA |
| RORA | 5.00e-01 | ligand-dependent nuclear receptor | NA | -6.00e-01 | NA | 2.0e-02 | ABCA1,Aox3,ARSG,ASNS,ATP1B1,B3GALT1,Cald1,Ccl2,CCL24,CCNA2,CD36,CDH2,CDKN1A,CISH,CXCL10,CYP27A1,CYP39A1,CYP7B1,ELOVL7,GADD45A,GADD45B,IGF1,IL17A,Mt1,MYOG,NAT2,NFKBIA,NNMT,NR1D2,NTRK2,PPP1R3C,PTGS2,RHBG,Scd2,SELENBP1,SEMA3F,SLC16A7,SLC25A24,SLC2A13,SLC41A2,Slco1a4,SNAI1,SOCS3,SREBF1,SULF2,UCP3,UGGT2,VIM | NA |
| LRP6 | 2.80e-01 | transmembrane receptor | NA | -6.00e-01 | NA | 1.0e-02 | ACTA2,ALDH1A1,AXIN2,CAV1,Ccl2,CCND1,COL1A1,IL17A,LEPR,MMP14,MMP2,PNPLA3,RHOA,RUNX2,SPP1,TGFB1,TTYH1,VIM | 1438 (21) |
| ERF | 0.00e+00 | transcription regulator | NA | -6.00e-01 | NA | 1.0e-02 | BCL11B,CDH1,COL4A6,COL7A1,ETV1,NOTCH4,ROBO2,SEMA7A,TP63,UTRN | NA |
| NREP | 2.50e-01 | other | NA | -6.10e-01 | NA | 0.0e+00 | ACTA2,COL3A1,FGF2,ITGA3,ITGA5,MMP2,PDGFB,PDGFRA,TAGLN,TGFB1 | 528 (7) |
| bafilomycin A1 | NA | chemical drug | NA | -6.10e-01 | NA | 0.0e+00 | Akr1b7,AXL,BCL2L1,CD83,CD9,CXCL10,FOXO1,GATA4,IRS1,KCNA5,KCNH2,NFKBIA,NR0B2,PTGS2,SLC7A1,SNCA,TNFRSF10A | 1666 (20) |
| NUP98-DDX10 | NA | fusion gene/product | NA | -6.10e-01 | NA | 2.0e-02 | A2M,ALOX5,C3AR1,C5AR1,Ccl6,CDK6,EGR1,GADD45B,HOXA5,HOXB5,MSR1,MYCN,PBX3,PTGS2 | NA |
| CH-223191 | NA | chemical reagent | NA | -6.10e-01 | NA | 0.0e+00 | ACTA2,AHR,CLDN1,COL1A1,COL3A1,EGLN2,ENTPD1,MAF,OCLN,PTGS2 | 1209 (13) |
| Sch-23390 | NA | chemical drug | NA | -6.10e-01 | NA | 1.0e-02 | BDNF,EGR1,EGR2,FGF2,IL17A,NTS,PLD2,PPP3CA,RYR1 | 1216 (21) |
| HSPB8 | -2.20e-01 | kinase | NA | -6.20e-01 | NA | 0.0e+00 | ACSL1,ALDOA,BMP4,CD36,CDK2,ICAM1,LPIN1,MAP1LC3B,MITF,PKM,PPARG,SLC2A1 | 1474 (18) |
| bryostatin 1 | NA | chemical drug | NA | -6.20e-01 | NA | 1.0e-02 | ARG1,BIRC3,CD22,CD44,CD86,CXCR4,FOXP3,ICAM1,IL2RG,IRF3,PRKCB,PRKCD | 1223 (14) |
| MFAP2 | 4.10e-01 | other | NA | -6.20e-01 | NA | 0.0e+00 | CDC42EP3,ITGA4,ITGB3,PTCH1,VCAN | NA |
| methapyrilene | NA | chemical drug | NA | -6.30e-01 | NA | 0.0e+00 | A2M,ACADL,ACADS,ACTG1,ALDOA,ANXA2,ANXA5,ATF3,BCKDHA,BTG2,C4BPA,CCND1,CD36,CDC34,CP,CRP,CTSS,EEF1A1,FABP1,GADD45A,GCLC,GFRA1,IGF1,IGFALS,LCAT,LGALS9B,MAOB,MAPK14,Mt1,NSFL1C,PC,PLCB1,PPP3CA,PRKCB,RIPK3,RXRG,SELENOP,SERP1,STMN1,TUBB | NA |
| riboflavin | NA | chemical - endogenous mammalian | NA | -6.30e-01 | NA | 0.0e+00 | FZD1,FZD6,GLI1,MMP2,PITX2,PTCH1,SFRP1,TIMP1,WNT4,WNT6 | 898 (11) |
| TSH | NA | complex | NA | -6.30e-01 | NA | 0.0e+00 | Ccl2,CCND1,CDK2,CDKN1A,CTSS,DIO1,EGR1,FOXO1,FZD1,GAPDH,GCH1,GNAI1,IGFBP5,IL1RN,KDR,Mt1,NOX4,PPARD,SLC2A1,SOCS1,SOCS3,TPO,TSHR,TTF2,WNT5A | 1422 (17) |
| PMP22 | -1.72e+00 | other | NA | -6.40e-01 | NA | 0.0e+00 | ABCA1,CSPG4,EMP3,FLOT1,MPZ,NEFL,P2rx7,PMP22,PRX | NA |
| DAG1 | -1.40e-01 | transmembrane receptor | NA | -6.40e-01 | NA | 3.0e-02 | CNP,Mbp,NOS1,SGCA,SLC2A1,SSPN,UTRN | NA |
| IGFBP1 | 1.20e-01 | other | NA | -6.40e-01 | NA | 4.0e-02 | BCL2L1,IGF1,ITGA2,ITGA5,ITGB3,TGFB1 | NA |
| morin | NA | chemical - endogenous non-mammalian | NA | -6.40e-01 | NA | 4.0e-02 | BCL2L1,CCND1,COL18A1,PTGS2,PTPN6,TIMP1 | NA |
| RARA | -6.60e-01 | ligand-dependent nuclear receptor | NA | -6.50e-01 | NA | 0.0e+00 | ABCA1,ABLIM1,ADAM10,ADAM17,ADH1C,ALDH1A1,ALOX5,ARNT2,ATP6V0A4,CA12,CALB1,CCNA2,CCND1,CD44,CD53,CD7,CD84,CD9,CD93,CDKN1A,CENPF,COBL,CP,CTSS,CXCR5,CYP26B1,DUSP1,E2F7,E2F8,EGR1,EGR2,EGR3,EIF5A2,ELL2,ENAH,ENOX1,FGFR1,FOLR2,FOXC1,FOXP3,GAP43,GATA4,GLI1,GSK3A,HOXA5,HOXD10,IFI44,IFI44L,IGFBP6,IL16,IL1R1,IRF1,IRF6,ITGA4,KIF23,KLF4,KNL1,LAMP2,LGALS1,MALL,MAOB,MAP1B,MAP3K10,METTL7A,MYCN,NCAPG,NEDD9,NR2F1,NRP1,NTN1,PENK,PHLDB1,PIK3CG,PITX2,PLK4,PTGS2,RARA,RARG,RARRES1,RET,RNF38,RSAD2,RTP4,RUNX1,SALL4,SESN1,SFTPB,SGSM3,SIPA1L1,SLC16A2,SP110,SPP1,STAT1,STRA6,STX3,TGFB1,THBD,TNFRSF10A,TNFRSF11B,TP63,TTC9,TTLL11,UBA7,UBXN10,UCP3,XK,ZNF367 | 1417 (21) |
| NANOG | NA | transcription regulator | NA | -6.50e-01 | NA | 1.0e-02 | ACVR1C,AHR,BMP4,CBFA2T3,CCND2,CDK6,CDKN1A,COL3A1,DCN,E2F5,EGR1,ESRRB,GATA4,GDF6,GLI1,GLI2,HOPX,HSPA1A/HSPA1B,ID2,ID4,IRF6,KDM4B,KDR,KLF4,LBX1,LGALS1,LTBP1,LYN,MAP1B,MAX,MYCN,PITX2,POLE4,PRR30,ROCK1,S100A6,SALL4,SMAD6,SMAD7,TAF1C,TBX3,THBS2 | 1366 (19) |
| homocysteine | NA | chemical - endogenous mammalian | NA | -6.50e-01 | NA | 0.0e+00 | ACADS,ALOX15,ANXA2,ASNS,ATF3,BCL2L1,BDH2,Ccl2,CCND1,CDKN1A,CXCL10,CXCL12,DDAH2,EEF1A1,EEF1D,ELOVL5,F3,FA2H,FADS1,FADS2,FGF1,FGF2,GADD45A,HCAR2,HERPUD1,LPL,MMP2,MSMO1,OLR1,OXTR,PHLDA1,PKM,Pmaip1,PRDX1,PTGIS,PTGS2,RETN,SNAI2,SOCS3,SREBF1,TIMP1,VCAM1 | 1359 (19) |
| 10E,12Z-octadecadienoic acid | NA | chemical - endogenous mammalian | NA | -6.50e-01 | NA | 0.0e+00 | ABCA1,ABCG1,ACSM3,ADAM17,ADIPOQ,APLN,ARHGEF15,ATF3,B3GNT7,BUB1,CA3,CACNA1G,CACNG4,CASP3,CAV1,Ccl2,CD36,CDK18,CLEC12A,CREB5,EBF1,EGR2,FADS1,FMO2,HMCN2,IGF1,IL1RN,LGALS12,LPIN1,MRGPRX2,NFAT5,NOTCH4,NR4A1,NR4A2,NR4A3,NXPH3,PLIN1,PLK2,PNPLA2,PPARG,PPP1R3B,PTGS2,RASGRF1,RETN,RHBDF2,SCN4A,SLC1A3,SLC38A3,SMTNL2,SNCAIP,SOX6,SOX7,SREBF1,TUBA8 | 850 (15) |
| CUL7 | NA | enzyme | NA | -6.50e-01 | NA | 3.0e-02 | CDH1,CDH2,SNAI2,VIM | NA |
| sorafenib | NA | chemical drug | NA | -6.50e-01 | NA | 0.0e+00 | ACTA2,BCL2L1,BTRC,CASP3,CCND1,CCND2,CDK6,CISH,COL1A1,CXCL10,HGF,HIF1A,IL2RA,MET,SOCS1,SREBF1,TWIST2,VIM | 1192 (15) |
| MAP3K4 | 2.10e-01 | kinase | NA | -6.60e-01 | NA | 0.0e+00 | CDH1,ICAM1,MMP2,PTGS2,SELE,SNAI2,TWIST1 | 1179 (16) |
| SMPD3 | -1.53e+00 | enzyme | NA | -6.60e-01 | bias | 0.0e+00 | FOXO1,ICAM1,IGF1,VCAM1 | 1162 (20) |
| ZBTB7A | 2.00e-02 | transcription regulator | NA | -6.60e-01 | NA | 2.0e-02 | BCL2L11,CASP3,CDK2,CDKN1A,DMBT1,IL2RA,MIA,NRP1,PKM,RBL1,SELE | NA |
| LCN2 | 3.60e-01 | transporter | NA | -6.60e-01 | NA | 0.0e+00 | ACTA2,ARG1,Ccl2,Ccl6,Ccl7,CCR1,CCR5,CDH1,CDH2,COL1A1,CORO1C,CXCL10,CXCL13,FBXO32,FN1,GFAP,HIF1A,IL1RN,KIF11,KIF23,MMP2,MRC1,MSN,PNPLA2,RARA,RUNX2,RXRA,SPP1,SREBF1,STRA6,TAGLN2,TGFB1,TINAGL1,TNFRSF11B,TRIM63,TWIST1,VIM | 1336 (18) |
| MSX2 | -3.40e-01 | transcription regulator | NA | -6.60e-01 | NA | 2.0e-02 | AQP4,BMP4,CCND1,CDH2,EGR2,EPHA4,LEF1,PPARG,PROX1,SPP1,TP63,TWIST1,VIM | NA |
| MYF5 | -1.48e+00 | transcription regulator | NA | -6.60e-01 | bias | 2.0e-02 | CDKN1A,CKM,LHX8,MYF5,MYOD1,MYOG | NA |
| progesterone | NA | chemical - endogenous mammalian | NA | -6.70e-01 | NA | 0.0e+00 | ACOT7,ACP5,ACRBP,ACSL1,ACTA1,ACTA2,ADAMTS1,ADIPOQ,ADRA2A,ADRB2,ALDH1A1,ALOX15,AMD1,AMPD3,APOD,ARID5A,ART3,ASGR2,ATF3,ATP1B1,B3GALNT1,BCAT1,BCL2L1,BCL6,BDNF,BHLHE40,BIRC3,C3,C5AR1,CA12,CA3,CASP3,CAV1,CCNA2,CCND1,CCR3,CCR5,CD1D,CD36,CD86,CDH1,CDH11,CDH2,CDK2,CDKL2,CDKN1A,CEBPD,CFB,CITED2,CKMT1A/CKMT1B,CLDN3,CNMD,CNR1,COL12A1,CP,CRYAB,CSF1,CSF3R,CX3CL1,CXCL10,CXCL12,CXCR4,CYP1B1,DBP,DLC1,DNAJB4,DPP4,ECE2,EDN3,EGF,EGR1,EIF5B,ELL2,ENC1,ENG,ENPEP,ERBB3,ERRFI1,ESPL1,EZR,F2R,F2RL1,F3,FAAH,FAM111A,FEN1,FKBP5,FN1,FOXC1,FOXO1,FOXP3,G6PD,GABARAPL1,GAD1,GAP43,GCH1,GFAP,GGCT,Ggta1,GJB2,GPAM,Gpr165,HDC,HGF,HIF1A,HLA-A,HOPX,HSD17B4,HSPA2,ICAM1,IGF1,IGFBP5,IKBKB,IL17RE,IL33,INHA,INHBA,IRS1,IRS2,ITGA1,ITGA11,ITGA2,ITGA5,ITGB3,JAM2,KCNH2,KCNK1,KDR,KLF10,KLF5,KLF9,LAMA2,LEPR,LGALS1,LGR5,LITAF,LPIN1,LPL,MCM7,MDK,MKI67,MME,MMP2,MPZ,MRC1,MTSS1,MX1,MYCN,MYO10,MYO1D,NCAM1,NEDD9,NET1,NFIL3,NFKBIA,NOP16,NPL,NR4A1,NRP1,NT5C2,OCLN,OXTR,PARM1,PBX3,PDLIM1,PDPN,PFKFB3,PGRMC1,PIK3R1,PKM,PLA2G7,PLCL1,PLIN4,PLK2,PLPP3,PMP22,PPARG,PPM1H,PROS1,PRSS35,PTBP3,PTGER1,PTGER3,PTGS2,PTX3,PYCARD,RASSF2,RELN,REM1,RETN,RNASE4,S100A4,S100A6,Scd2,SCNN1G,SFRP4,SGK1,SIX4,SKP2,SLC1A5,SLC27A1,SLC2A1,SOCS1,SPHK1,SPP1,SREBF1,ST3GAL1,STAT1,STAT5B,STEAP1,SYP,TBC1D8,TGFB1,TGFBI,THBD,THBS1,TIMP1,TIPARP,TNFRSF1B,TRAF5,TRPV1,UGCG,VIM,WNT4,WNT6 | 1772 (20) |
| EGFR | -3.60e-01 | kinase | NA | -6.70e-01 | NA | 0.0e+00 | AARSD1,ABI1,ACOT7,ACTA1,ACTA2,Actn3,ACVR1,AMD1,ANXA1,ANXA8/ANXA8L1,ARG1,ATAD3A,ATP8B1,AXIN2,B3GALNT1,B3GALNT2,B3GNT2,B3GNT5,BCKDHA,BCL2L1,BCL2L11,BCL6,BTG1,CASP3,CAV1,CCNA2,CCND1,CD109,CD47,CDH1,CDK2,CDK6,CDKN1A,CHI3L1,CHKA,CLK1,CMA1,COL1A1,COL3A1,COL5A2,COL8A1,CRYAB,CTSK,CXCL10,CXCL12,CXCL14,CXCR4,DPY19L3,DUSP1,E2F2,EDEM1,EGF,EGR1,EGR3,EIF6,ERAP1,ERBB3,EXOSC5,F2R,F2RL1,F3,FAP,FBN1,FKBP11,FN1,FOXP3,GADD45A,GALNT10,GCNT2,GFAP,GNPDA2,GXYLT2,GZMB,HAS2,HDC,HERPUD1,HIF1A,HSPE1,ICAM1,IER3,IGF1,IGFBP4,IGFBP5,IL33,IQGAP2,IRF1,ITGA2,ITGA6,ITGB4,JAG1,JUND,LAMA3,LAMA4,LAMC2,LEF1,MATN2,MCOLN1,MET,MME,MMP14,MMP2,NFKBIA,NOX1,NUDC,NUP210,OSMR,PDLIM7,PHF20,PIP4K2B,PKM,PKP3,PLA2G4A,PLAT,PLK1,PPIA,PRKCZ,PROM1,PSMB1,PSMB5,PTGES,PTGIS,PTGS2,PTPRF,QTRT1,RANBP1,RASSF9,RND3,RP2,RUNX1,RUNX2,SDC1,SEC61A2,SEMA7A,SERPINE1,SFRP1,SKP2,SLC2A1,SLC37A4,SLC7A1,SLCO4A1,SNAI1,SNAI2,SNX3,SOCS3,SPHK1,SRSF1,ST6GAL1,STAT6,STT3A,SUSD5,TBXAS1,Tchh,TCOF1,TGFA,TGFB1I1,THBS1,TIMM9,TMEM123,TNC,TNFAIP6,TNFRSF11B,TPST1,TSPAN1,TUBB4A,TWIST1,UGT8,UNC5B,VCAN,VIM,VTCN1,WEE1,WNT10B,WNT16,WNT4,WNT6,ZEB2 | 1509 (19) |
| 1,1-bis(3’-indolyl)-1-(4-trifluoromethyl-phenyl)methane | NA | chemical reagent | NA | -6.70e-01 | NA | 5.0e-02 | ATF3,CAV1,CAV2,CDKN1A | NA |
| PD184352 | NA | chemical drug | NA | -6.70e-01 | NA | 2.0e-02 | BCL2L1,BCL2L11,CCND1,EGR1,NR4A1,NR4A3,OPTN,PPP1R14B,TRMT112 | NA |
| ROCK | NA | group | NA | -6.70e-01 | NA | 0.0e+00 | ACTA1,ACTA2,CCND1,CDH1,CDKN1A,CNN1,COL1A1,COL3A1,ETS1,F3,FN1,ICAM1,IL17A,MYOD1,NOP16,PPARG,RUNX2,SORT1,SPP1,TAGLN,TGFB1,THBS1,VCAM1 | 1140 (19) |
| ID3 | 2.40e-01 | transcription regulator | NA | -6.80e-01 | NA | 0.0e+00 | ADIPOQ,BATF,BCL2L1,BCL2L11,BCL3,BCL6,BTG2,CBFA2T3,CCND2,CCNE2,CCR1,CCR5,CD44,CD83,CDC25B,CDK20,CDKN1A,CDKN2C,CSF1,CSF2RB,CXCR4,CXCR5,DTX1,DTX2,DUSP1,DUSP10,E2F2,EGR2,FCER1G,FLT3LG,FOXO1,FOXO3,Foxp1,FOXP3,GADD45B,GADD45G,HIF1A,HOMER2,ICAM1,IFI16,IGFBP4,IKZF2,IL10RA,IL2RB,INHBB,IRF4,IRF5,IRF6,IRF8,ITGB3,KLF6,LEPR,LGALS1,LMO2,MAF,MAP3K14,MMP2,NFAT5,NR4A1,NR4A3,PAWR,PIK3C2B,PIK3R1,PKD2,PPAN,PRDM1,PTPN3,RAP1GAP,RAPGEF4,REL,SDC1,SELE,SEMA7A,SLAMF1,SMAD7,SOCS3,TNFRSF25,TNFRSF4,TNFSF8,TRAF5,VCAM1,ZBTB16 | 1129 (18) |
| A-769662 | NA | chemical reagent | NA | -6.80e-01 | NA | 0.0e+00 | ABCA1,ABCG1,ACTA1,ACTA2,ARG1,FN1,LCAT,PPARG,SERPINE1 | 1421 (25) |
| TRAPPC1 | 5.20e-01 | other | NA | -6.80e-01 | NA | 2.0e-02 | Casp12,CDKN1A,CKAP4,DNAJA1,EDEM1,HERPUD1,HSP90AA1,HSPA1A/HSPA1B,HSPA2,LMAN2,MAN1C1,NSFL1C,PDIA4,PREB,SAR1B,SEC24D,SEC61A2,STT3A,UBE2D3,UBE2G2,UBQLN2,UBXN1,VCP | NA |
| CNR2 | 1.60e-01 | G-protein coupled receptor | NA | -6.80e-01 | NA | 4.0e-02 | Ccl2,CCND1,CXCL10,EGR1,FN1,GRK5,ITGAL,PTGS2,TGFB1 | NA |
| ADGRE2 | NA | other | NA | -6.90e-01 | NA | 0.0e+00 | ALDH1A3,AXL,CA9,CCND1,CD34,CDKN1A,COL6A3,CSF2RA,CXXC5,DOCK2,FSTL1,GLUL,GPNMB,ITGB3,LTBP1,TGFB1,THBS2,TLR4,WNT5A | NA |
| GRIN1 | NA | ion channel | NA | -6.90e-01 | NA | 0.0e+00 | ATF3,BMP15,CAMK2A,COL1A1,CSF1,DCN,EGR3,EPHA3,FN1,HOXD10,LOX,LOXL2,LUM,MMP14,MMP2,PENK,PPP5C,SERPINE1,SPARC,TNC | 1445 (22) |
| CIITA | -9.10e-01 | transcription regulator | NA | -6.90e-01 | NA | 2.0e-02 | B2M,CCND1,CD74,COL1A1,CTSE,FN1,GCNT2,HLA-A,HLA-DOB,HLA-DQA1,HLA-DRA,SLC26A3,TGFB1 | NA |
| TBK1 | -3.00e-01 | kinase | NA | -6.90e-01 | NA | 0.0e+00 | ACTA2,BACH1,BCL2L1,CD86,CDKN1A,CXCL10,EDN1,FGL2,H2-T24,HDC,ICAM1,IFI16,IFI44,IFIH1,IFIT1,IFRD2,IL15RA,INHBA,IRF3,ISG15,NMI,OAS3,OASL,Oasl2,PLA1A,PTGS2,RBL1,RGCC,RILPL1,RSAD2,SELE,SLCO3A1,SLFN13,TLR2,USP18 | 1263 (18) |
| peoniflorin | NA | chemical drug | NA | -7.00e-01 | NA | 1.0e-02 | CASP3,DDAH1,ENO2,GLO1,RUNX1,SAR1B,SNCA,TUBB | NA |
| ARRB1 | -2.00e-01 | transcription regulator | NA | -7.00e-01 | NA | 0.0e+00 | ADRB2,Ccl2,COL1A1,EGR1,ENAH,F3,IL17A,IRS2,LEF1,LPL,PTGS2,SERPINE1,SNAI1,SPP1,VCAM1 | 1477 (21) |
| N-nitro-L-arginine methyl ester | NA | chemical drug | NA | -7.00e-01 | NA | 0.0e+00 | ACTA1,ADIPOQ,APLN,ATF3,BCL2L1,BGN,CASP3,Ccl2,CCR5,CD83,CD86,CDK14,COL3A1,CSF1,CYBA,CYBB,FN1,GFAP,HIF1A,ICAM1,IL17A,ITGB3,MAP1B,MYH7,NFKBIA,NOS1,OLR1,PDK4,PPARD,PTGS2,RHOA,SELE,SERPINE1,SLC2A1,SREBF1,TGFB1,TIMP1,TLR2,TLR4,UCP3,VCAM1 | 1721 (20) |
| USP22 | 2.10e-01 | peptidase | NA | -7.10e-01 | NA | 0.0e+00 | BCL2A1,CCND2,Cd33,CDKN1A,CHI3L1,CMTM3,CSF2RA,CSF2RB,CSF3R,CYBB,DBN1,EEF1A2,ESRRB,FAXDC2,FCGR2B,FN1,FOXP3,IFIT1,IL2RB,ITGB2,KLHL5,LRRN1,MBOAT2,MRC1,MSR1,NCF1,NCF2,NCF4,OAS3,PARP14,PLIN1,PPARG,PTPN6,PTPRC,SEMA4F,TGFB1,USP18 | 1168 (21) |
| CALC | NA | group | NA | -7.10e-01 | NA | 0.0e+00 | AQP4,CD86,CREM,EDN1,IL33,MAX,SORT1,VEGFC | 1007 (15) |
| SIN3A | -1.20e-01 | transcription regulator | NA | -7.10e-01 | NA | 0.0e+00 | BCL6,BDNF,CASP3,CCND2,CDH1,COL1A1,CTSK,E2F2,FBXO32,FOXP3,GADD45B,HLA-DRA,KLF10,KLF6,MAD1L1,PMM1,PTGS2,SERPINE1,SMAD7,TMEM71 | 1296 (16) |
| KCNJ10 | -6.70e-01 | ion channel | NA | -7.10e-01 | bias | 1.0e-02 | Ccl2,CXCL10,GADD45A,GBP5,ICAM1,Pmaip1,SGCA,TIMP1 | NA |
| CRYAB | -1.71e+00 | other | NA | -7.10e-01 | NA | 1.0e-02 | CASP3,CCND1,COL2A1,CRYAB,FBXO32,IL17A,MME,MYOD1,MYOG,SCN5A | NA |
| BSG | 1.60e-01 | transporter | NA | -7.10e-01 | NA | 0.0e+00 | BCL2L1,BCL2L11,CCND1,CDH1,CDH2,CRP,CXCL12,EIF2AK3,HIF1A,IL2RA,KDR,MMP2,PLK1,SELP,SERPINE1,SLC16A1,TGFB1,VIM | 1518 (19) |
| DGCR8 | -2.00e-01 | enzyme | NA | -7.10e-01 | NA | 0.0e+00 | ACTA2,ADGRG6,BDNF,CCND1,CDH1,CNN1,CNP,EGR1,EGR2,ERBB3,ID2,ID4,JAG1,MITF,MPZ,NCAM1,NRCAM,PLP1,PMP22,RARA,SMO,SMOC1,SOX10,TAGLN,TNC | 1326 (17) |
| oblimersen | NA | biologic drug | NA | -7.20e-01 | bias | 0.0e+00 | ATF3,BCL2L1,CDKN1A,CEBPD,DUSP1,GADD45A,GADD45B,IFI16,IFI44,IFIT1,ISG15,KLF10,MAFF,MX1,MYH3,OASL,PCF11,RSAD2,SIX1,STAT1 | NA |
| NFKBIB | 1.05e+00 | transcription regulator | NA | -7.20e-01 | NA | 1.0e-02 | BCL2A1,BCL2L1,BCL2L11,CARD6,Casp12,CD86,DAPK1,EGR1,FGF10,ICAM1,NFKBIA,RYR1,SELE,SMAD7,TEK,VCAM1 | NA |
| ST3-Hel2A-2 | NA | chemical reagent | NA | -7.20e-01 | bias | 0.0e+00 | ATF3,BCL6,EGR2,GADD45A,HERPUD1,IER3,NR4A2,PHLDA1 | 837 (10) |
| SIAH2 | 6.50e-01 | transcription regulator | NA | -7.20e-01 | NA | 3.0e-02 | EGLN1,FGF1,HIF1A,PLK3,SIAH2,TP53BP2 | NA |
| KLF11 | -2.60e-01 | transcription regulator | NA | -7.20e-01 | NA | 0.0e+00 | ACSL5,ACTA2,ADAMTS1,ADAMTS8,CAV1,CHRNA1,CHRNA4,CHRND,COL3A1,CXCR4,DCN,EDN1,EGF,ENG,GREM1,HGF,IDH3A,ITGA1,ITGA2,ITGA3,ITGB3,LOX,LTBP1,MAOB,MMP14,MMP2,PDGFB,PDK4,PLA2G4A,PLAT,PPARG,SERPINE1,SERPINH1,SMAD6,SMAD7,SNAI1,STAT1,STAT6,TGFB1,THBS1,THBS2,TIMP1,TSHR | 1163 (16) |
| spermine nitric oxide complex | NA | chemical toxicant | NA | -7.30e-01 | NA | 0.0e+00 | ASAH2,BCL2L1,ICAM1,MYH14,S100A10,SELE,VCAM1 | 1517 (24) |
| LINC00842 | NA | other | NA | -7.30e-01 | NA | 0.0e+00 | CDH1,CDH2,FN1,SERPINE1,SNAI1,VIM | 812 (16) |
| INHBA | -2.52e+00 | growth factor | NA | -7.30e-01 | NA | 0.0e+00 | ACTA2,ACVR1,ACVR1B,ADRB2,ANKRD1,ARIH2,BAMBI,BCL2L1,CALB1,CCND1,CCND2,CD28,CDH1,CDH2,CDKN1A,CHD7,CHMP4B,CXCR4,DACH1,ERBB3,F13A1,FN1,FOLR2,GULP1,IGF1,INHA,INHBA,INHBB,IRF1,ITGA11,KLF4,LOX,MAD1L1,MAF,MMP2,MYH2,MYH7,NAV3,NR4A2,NR5A1,NRK,PCSK5,PGM2L1,PLOD2,PRDM1,PSMD9,SEL1L3,SERPINE1,SMAD6,SMAD7,SOCS1,STAR,STRBP,TAGLN,TAL1,TIMP1,TNNT2,VAV3,VIM | 1469 (25) |
| MCAM | 2.00e-02 | other | NA | -7.30e-01 | NA | 0.0e+00 | ATF3,CDH1,FN1,MMP2,SNAI2,VIM | 1303 (18) |
| INT-767 | NA | chemical drug | NA | -7.30e-01 | NA | 3.0e-02 | Ccl2,CD36,CYP27A1,CYP7B1,FABP1,MRC1,NR0B2,OLR1,SREBF1 | NA |
| GNAS | 7.60e-01 | enzyme | NA | -7.30e-01 | NA | 0.0e+00 | ADAMTS1,ADD3,ALCAM,ATF3,ATP1A1,B3GNT7,BCL2L1,BCL6,CABLES1,CACNA1D,Ccdc50,Ccl2,CD200,CD22,CD86,CDK2,CHST10,CIITA,CREM,CYTIP,FYN,GADD45G,GLI1,GLI2,GPR171,HDAC7,HDAC9,IFI16,IL2RA,INHA,INPP5D,ITGB3,KLF4,LITAF,LMO2,MAFF,NR4A1,NR4A2,NR4A3,NRP1,P2RY10,PDE3B,PDE4A,PENK,PLA2G4A,PLK2,PMEPA1,PPARG,PRKCB,PRKCE,PTCH1,RAPGEF4,RGS2,SEMA3A,SIPA1L1,SLA,SLAMF1,SPARC,SPP1,STAR,SWAP70,SYK,THBS1,TNFRSF1B,TRIB1,VPS37B | 1333 (18) |
| CYP1B1 | -1.62e+00 | enzyme | NA | -7.40e-01 | NA | 0.0e+00 | ACOT11,ACSF2,ADCY7,ARNT2,CACNA1D,Ccl7,CCND1,CDH3,CHRNA4,CLDN1,CYP1B1,CYSLTR1,ETHE1,FGF10,FLRT3,GATM,IFNLR1,INSC,LDHB,LMO1,MICAL1,MID1,MMP2,Mt1,PPIC,PTPRF,RBBP4,SKP2,SLC46A3,SLFN13,THBS2,WEE1 | NA |
| mir-183 | NA | microRNA | NA | -7.40e-01 | NA | 1.0e-02 | CDH1,EGR1,FN1,HERC6,IFI44L,IFIT1,IRS1,ISG15,KLF4,NMI,RSAD2,RTP4,SLC39A9,SP110,STAT1,VIM | NA |
| CYTOR | NA | other | NA | -7.40e-01 | NA | 0.0e+00 | BCL2L12,CDH1,CDH2,CLDN1,CREB1,MAPK14,SNAI1,SNAI2,STAT1,VIM | 1283 (20) |
| Bcl9-Cbp/p300-Ctnnb1-Lef/Tcf | NA | complex | NA | -7.50e-01 | bias | 5.0e-02 | AXIN2,CCND1,CD44,PPARD | NA |
| SPRY4-IT1 | NA | other | NA | -7.50e-01 | NA | 0.0e+00 | CDH1,CDH2,CLDN3,OCLN,SNAI1,VIM | 1024 (12) |
| olaparib | NA | chemical drug | NA | -7.50e-01 | NA | 1.0e-02 | BRCA2,BTG2,CCNA2,CCND1,CDC25B,CDK6,CDKN1A,CXCL10,NCAM1,PTGS2,SYP | 1303 (23) |
| mir-23 | -6.80e-01 | microRNA | NA | -7.50e-01 | NA | 1.0e-02 | CDH1,CELF2,FBXO32,GATM,HIF1A,HIF1AN,HOXD10,IGF1,MYCN,RUNX2,SNCA,SPP1,TRIM63 | 1280 (16) |
| PIK3R2 | 4.00e-02 | kinase | NA | -7.50e-01 | NA | 1.0e-02 | BCL2L1,CXCL10,FOXO1,ISG15,MKI67,PIK3R1 | NA |
| PRKCD | -1.67e+00 | kinase | NA | -7.50e-01 | NA | 0.0e+00 | ABCA1,ARID3B,BCL2A1,BCL2L1,BIRC3,Ccl2,CCNA2,CCND1,CDKN1A,CIITA,COL1A1,CX3CL1,CXCL10,CXCL12,CXCL16,DUSP6,FBN1,FZD1,GFAP,GLI1,HRH1,ICAM1,IL1RN,IL2RG,KLF5,KLF6,LBH,LIPG,LYST,MAP1LC3B,MAST4,MMP2,MPZ,MSI1,NFKBIA,NOTCH2,NOX1,NR0B2,NR4A1,OSR2,PDLIM7,PROM1,PTCH1,PTGS2,PTPN6,SERPINE1,SIK3,SMAD6,SOCS1,SPHK1,STAR,TLR2,TNFRSF11B,TPBG,TTC9,UGCG,VCAM1,ZFP36 | 1122 (15) |
| NFKB2 | 2.10e-01 | transcription regulator | NA | -7.50e-01 | NA | 0.0e+00 | ANXA5,BACE2,BCL2L1,BCL2L11,BIRC3,BMP4,C1QTNF3,CCDC141,Ccl2,CCND1,CD34,CD83,CD86,CDKN1A,CTSS,CX3CL1,CXCL12,CXCL13,CXCR4,CXCR5,FAP,FZD5,GBP5,GDF6,GPR183,GRIN3A,HLA-DQA1,IGFBP4,IGFBP5,IL34,IRF4,KCNMB4,LMCD1,MAF,MARCKSL1,MAT2A,MMP2,NOD2,PAMR1,Pcp4l1,PDGFRA,PLPP3,PPARGC1B,PTGS2,RRAD,SEMA3E,TGM4,TNFAIP2,VCAM1,ZFP36L1 | 1048 (13) |
| RGS4 | -8.30e-01 | enzyme | NA | -7.60e-01 | NA | 0.0e+00 | ACTA1,ADAMTSL5,ADHFE1,CRHR2,EIF5A2,ESRRB,FBLIM1,ID4,IGF1,INPP5J,KCNN1,KDR,MBNL1,MYH7,MYL2,NEFL,NR4A2,NUP210,PAQR8,PRSS12,PYGL,SCN7A,SIM1,SLC35A5,SLIT3,SPP1,UGCG,WDFY4 | 1029 (18) |
| CSNK2A1 | 1.80e-01 | kinase | NA | -7.60e-01 | NA | 0.0e+00 | AHR,BCL2L1,CCNA2,CCND1,CDH1,DTX1,DUSP6,FN1,GNAL,ITGA3,ITGB4,MCM7,SNAI2,TP63,VIM,WEE1,ZFP36 | 1313 (19) |
| nitroprusside | NA | chemical drug | NA | -7.60e-01 | NA | 3.0e-02 | BCL2L1,BDNF,CAV1,CREB1,DUSP6,EGR1,FOXO1,IGF1,MYH14,PTGS2,RHOA,SLC12A4,SLC1A4,TLR2,TNFRSF11B | NA |
| LCOR | NA | transcription regulator | NA | -7.60e-01 | NA | 2.0e-02 | CDH1,CDKN1A,CYP26B1,FKBP5,IGFBP4,TFPI2 | NA |
| isoniazid | NA | chemical drug | NA | -7.60e-01 | bias | 3.0e-02 | FLT3LG,IL7,PIK3R1,TRPC3 | NA |
| FOXP3 | 2.03e+00 | transcription regulator | NA | -7.70e-01 | NA | 0.0e+00 | ANXA1,BCL2L11,CCR1,CCR3,CD101,CD200R1,CD226,CDKN1A,CSF1,CXCL13,CXCR4,CYSLTR1,DUSP6,EGR1,ENTPD1,EZH2,FEN1,FGL2,FOXP3,GAPDH,GBP2,GBP4,HLA-A,ID2,IGFBP4,IKZF2,IL10RA,IL17A,IL17RA,IL1RL1,IL2RA,IL2RB,IRF4,ITGAE,LGALS1,LTB4R,MAF,METTL9,MMP2,NEB,NFIL3,NPR1,NR4A1,NR4A3,NRP1,P2RY10,PDE3B,PLAGL1,Pmaip1,PPARG,PRDM1,RUNX1,SDC4,SKP2,SLC16A3,SLCO4A1,SMAD7,SWAP70,TGFB1,TLR10,TNFRSF4,TNFSF8,ZEB2 | 1228 (17) |
| pidnarulex | NA | chemical drug | NA | -7.70e-01 | NA | 1.0e-02 | ALDH1A1,BCAS1,BTG2,CACNA1B,CDKN1A,CHCHD4,CPNE7,E2F7,EGR1,FKBP9,GADD45A,IER3,INHBA,KIAA1549L,L1CAM,LOXL4,MAP1LC3B,PLK2,SESN1,SMIM10L1,SYT17,TENM2,ZDHHC2 | NA |
| HDAC5 | -3.50e-01 | transcription regulator | NA | -7.70e-01 | NA | 0.0e+00 | ACADL,ACSL1,ACTA1,ACTA2,CASP8,CDKN1A,CENPF,CKM,DAPK1,EGR2,GAP43,HLA-DRA,KIF11,KLF6,LPL,MAG,MPZ,MYCN,MYH7,MYOG,NCAPG,NDUFA1,NR4A1,PMP22,PPARG,PRX,PYGM,RUNX2,SIX1,TAGLN,TWIST1 | 1443 (24) |
| trans-cinnamaldehyde | NA | chemical drug | NA | -7.70e-01 | NA | 4.0e-02 | CASP1,CDKN1A,EGR1,GCLC,GSR,NCF1,NFE2L2,PTGS2,SERPINE1 | NA |
| PTPN3 | -8.50e-01 | phosphatase | NA | -7.80e-01 | NA | 0.0e+00 | ADAM17,CDKN1A,COL1A1,E2F2,FN1,JAG1,PDGFB,SERPINE1,SMAD7,TAGLN,TGFBI | 1420 (20) |
| ursodeoxycholic acid | NA | chemical - endogenous mammalian | NA | -7.80e-01 | NA | 0.0e+00 | ABCC3,BCL2L1,Ccl2,CDK2,COL1A1,CREBZF,CX3CL1,CXCL10,CYP27A1,DLC1,GCLC,GLI1,IRS1,MAF,NFE2L2,PRKCZ,PTGS2,SCTR,SPARC,SPP1,SREBF1,TGFB1,TIMP1 | 1433 (25) |
| PALMD | 3.60e-01 | other | NA | -7.80e-01 | bias | 1.0e-02 | CASP3,HIF1A,ICAM1,PFKFB3,PGK1,PIK3R1,PKM,RUNX2,SLC2A1,VEGFC | NA |
| MAP2K7 | 3.60e-01 | kinase | NA | -7.90e-01 | NA | 1.0e-02 | ANGPT2,ATF3,BIRC3,BTRC,CCND1,CDKN1A,CXCL10,ERCC1,FCGRT,FN1,IL1R1,KLC1,MAOB,MAP2K4,MYH7,OCLN,PLA2G4A,TFPI2 | 1329 (22) |
| FTO | 4.10e-01 | enzyme | NA | -7.90e-01 | NA | 5.0e-02 | ALDH1A1,CCND1,CD44,DACT1,HSPA1A/HSPA1B,ICAM1,IGF1,MMP2,MYH7,PDE1C,PDGFC | NA |
| KLF5 | -2.53e+00 | transcription regulator | NA | -7.90e-01 | NA | 0.0e+00 | ACTA2,ANO1,ARG1,BCL2L1,CCNA2,CCND1,CD34,CD44,CDH1,CDH2,CDKN1A,CEBPD,CGREF1,CSRNP1,CXCL12,CXCR4,DMP1,DUSP1,EGR2,GPSM1,HHEX,HIF1A,HLF,JAZF1,KLF5,LGR5,LITAF,MAFF,MEOX2,NMI,NR2F1,PDGFB,PPARD,PPARG,PREB,PTGES,RARA,RUNX1,SMAD7,SORCS2,SP140,TAGLN,TCF23,UCP3,ZFP36L1 | 1494 (20) |
| PLAG1 | -4.00e-02 | transcription regulator | NA | -7.90e-01 | NA | 1.0e-02 | CD300C,CDC42EP4,CLTB,CNKSR1,CREB3L1,EGR1,KRT19,LILRB3,MAP2,MLXIP,MYRF,NPTXR,PIR,PPIC,PTP4A3,RNASEH1,SMARCD3 | NA |
| sulforafan | NA | chemical drug | NA | -8.00e-01 | NA | 0.0e+00 | ADAMTS1,Akr1b7,ALDH1A1,ALDH1L2,AOX1,ARID5B,BCL2L1,CASP3,CCND1,CCNE2,CD44,CDC25B,CDK6,CDKN1A,CHRNA4,CNMD,COL8A2,CRYZL1,CSF1R,DDX6,ENPEP,EPHX1,ERBB3,FTL,GBE1,GCLC,GOLGA4,GSR,HIF1A,HLA-A,ICAM1,IL17A,KDR,MATK,MMP14,MRPL41,MSTN,Mt1,MYH10,NEU1,NFE2L2,NFKBIA,NR0B2,NRK,PDK2,PGRMC1,PHKA1,PIK3R1,PIR,PPARGC1B,PRDX5,PSMB5,PTGES,PTGS2,PTPRC,RUNX1T1,SELE,SLC25A24,SOCS3,SPRED2,STAR,SULF2,TBC1D8,TKT,TST,TWIST2,USP18,VCAM1,VEGFD,VIM,ZFC3H1 | 1340 (19) |
| PML | -5.20e-01 | transcription regulator | NA | -8.00e-01 | NA | 0.0e+00 | ACADL,ACADS,ACTG1,ADIPOQ,CCND1,CDH2,CDK2,CDKN1A,CFL1,CIITA,CIT,CXCR4,DNAJB4,EPSTI1,FABP1,FTL,GADD45A,GPAM,HERC6,HLA-DRA,ID2,IFI44,IFI44L,IFIH1,IFIT1,ISG15,LPL,MAF,MAFF,MX1,NFE2L2,NSFL1C,OAS3,PDK4,PRDX1,RXRA,SNAI1,SNAI2,SREBF1,STAT1,STMN1,SUMO2,TPD52L2,UBE2M,UCP3,VIM | 1447 (22) |
| MAP2K4 | 6.50e-01 | kinase | NA | -8.00e-01 | NA | 0.0e+00 | ATF3,BCL2L1,BIRC3,CCND1,CD44,CD86,CDKN1A,CRP,CXCL10,ERRFI1,FLNA,GADD45A,MYH7,PLA2G4A,PPARD,PPARG,PRDX1,PTGS2,ROCK1,TGFB1 | 841 (18) |
| MSC | -4.00e-02 | transcription regulator | NA | -8.00e-01 | NA | 0.0e+00 | AMPD3,CHL1,CKM,CSGALNACT2,EPSTI1,FLI1,FUT7,GPAT3,HGF,IFI44,IFI44L,IFIT1,ITGA9,LGALS12,MYBPC2,PCED1B,PIEZO2,POU2F2,SPP1,TLR7,TRIB1 | NA |
| NRF1 | -5.00e-02 | transcription regulator | NA | -8.00e-01 | NA | 5.0e-02 | ATP1A1,ATP1B1,CD47,CDH1,CDH2,CLDN1,COX4I1,COX6B1,ESM1,GCLC,IL1RN,Mt1,Pmaip1,PSMC1,SNAI1,SNAI2,VIM,VSNL1 | NA |
| TCR | NA | complex | NA | -8.00e-01 | NA | 0.0e+00 | ABLIM1,ADORA2A,ALDOA,ALOX12,APOD,BATF,BCAT1,BCL2A1,BCL2L1,BCL2L11,BCL3,BIN1,BIRC3,CCND1,CCR1,CCR3,CCR5,CD200,CD28,CD44,CD6,CDH1,CDK2,CISH,CREB1,CXCL10,CXCL13,CXCR4,CXCR5,CYTIP,DHX58,DKC1,ECH1,EGR1,EGR2,ELL2,ETV5,F5,FLNA,FOXP3,FYN,GADD45B,GADD45G,GBP4,GZMB,HIF1A,IFI44,IFI44L,IFIH1,IFIT1,IL16,IL17A,IL18R1,IL1RL1,IL2RA,IL7,IRF1,IRF4,ISG15,ITGB7,LCP2,LDHB,LSM3,MAF,MDH1,MX1,MYCN,NAB2,NFKBIA,NHP2,NR4A1,NRP1,OASL,PDE3B,PDIA4,PGK1,PIK3R1,PIK3R3,PRDM1,PTPRC,RASGRP1,REL,RGCC,RNF128,RPL17,RPL22,RPL6,RPS15,RPS16,RPS2,RPS3,RSAD2,RUNX1,SEMA3A,SIAH2,SLAMF1,SLC1A5,SLC2A1,SMAD7,SOCS1,SOCS3,SPHK1,SPP1,STAT1,Tcf7,TGFB1,TLR10,TLR4,TLR7,TNFRSF1B,TNFRSF4,TRAF5,UNC13D,ZBTB7B,ZC3HAV1 | 1449 (16) |
| MTORC1 | NA | complex | NA | -8.10e-01 | NA | 1.0e-02 | AHR,CCND1,ELF4,FOXP3,HIF1A,IL17A,KLF4,MAG,MAT2A,MOG,NFIL3,NOX4,PKM,PLP1,PTGS2,SLC2A1,SREBF1 | 1583 (22) |
| EN1 | -5.50e-01 | transcription regulator | NA | -8.10e-01 | NA | 4.0e-02 | ACTA2,ALDH1A1,CCND1,COL1A1,SLC18A2,SNCA | NA |
| PER1 | 1.60e+00 | transcription regulator | NA | -8.10e-01 | NA | 5.0e-02 | B2M,BCL2L11,CCND1,DBP,PER1,PER3,WNK1 | NA |
| apatinib | NA | chemical drug | NA | -8.10e-01 | NA | 0.0e+00 | ASNS,GAD1,GFPT2,GPT2,IL4I1,SFXN1,SLC1A4,SLC1A5,SLC25A38,SLC36A1,SLC38A1,SLC38A9,SLC6A9,SLC7A8 | NA |
| RLIM | 1.70e-01 | enzyme | NA | -8.20e-01 | bias | 0.0e+00 | CDH2,CDKN1A,FN1,SERPINE1,SMAD7,SNCA,VIM | 573 (9) |
| PDCD5 | 4.70e-01 | other | NA | -8.20e-01 | bias | 1.0e-02 | ATP2A2,DRAM1,FOXP3,SERPINE1,THBS2,TNC | 1332 (16) |
| beta-1,3-glucan | NA | chemical drug | NA | -8.20e-01 | NA | 2.0e-02 | FGF1,FGF2,ITGB3,PDGFB,TGFA,TGFB1 | NA |
| RXFP2 | 1.25e+00 | G-protein coupled receptor | NA | -8.20e-01 | NA | 3.0e-02 | AMHR2,DHH,INHBB,NOTCH4,SOX18,SOX7 | NA |
| PRKRA | -4.80e-01 | other | NA | -8.20e-01 | NA | 3.0e-02 | DCAF6,IRF1,MAF,PROS1,RET,THBS1 | NA |
| zalcitabine | NA | chemical drug | NA | -8.20e-01 | NA | 3.0e-02 | CXCL12,EGLN1,EGLN2,PGK1,SLC2A1,USP18 | NA |
| DIRAS3 | NA | enzyme | NA | -8.20e-01 | NA | 4.0e-02 | CCND1,COL2A1,DNASE1L3,HLA-DQA1,MYL1,TFPI2 | NA |
| mannose | NA | chemical - endogenous mammalian | NA | -8.20e-01 | NA | 4.0e-02 | BCL2L1,GPD1,HAS2,ICAM1,NR4A1,THBS1 | NA |
| CCAT2 | NA | other | NA | -8.20e-01 | NA | 1.0e-02 | ACTA2,CASP3,CCND1,CDH1,TGFB1,VIM,ZEB2 | NA |
| 14,15-epoxyeicosatrienoic acid | NA | chemical - endogenous mammalian | NA | -8.20e-01 | NA | 1.0e-02 | ADIPOQ,CD44,CTSK,FGF2,PIK3CG,PLAT,TNFRSF11B | NA |
| mir-146 | NA | microRNA | NA | -8.20e-01 | NA | 0.0e+00 | ALDOA,APBA3,ARG1,ARHGAP24,ATN1,CADM4,Ccl2,CXCL10,DUSP1,EIF2AK3,EVI2B,F3,FADD,FOXP3,GAPDH,GPI,HIF1A,IFITM3,IL17A,IL18BP,IRAK2,ISG15,ISLR,KIT,MMP2,MTERF3,NFYA,NPL,PDGFRA,PKM,PNPT1,PTGS2,QPCT,RNASEH1,RNF5,RUNX1,SLC19A2,SOCS1,STAT1,TLR4 | 1053 (15) |
| TCF3 | -1.30e-01 | transcription regulator | NA | -8.30e-01 | NA | 0.0e+00 | ABCC8,ADIPOQ,ALCAM,ARHGAP4,ATF3,AXIN2,BCL2L11,BCL6,BUB1,CASP3,CBFA2T3,CCNA2,CCND2,CCNE2,CCS,CD200R1,CD93,CDC25B,CDH1,CDK20,CDK6,CDKN1A,CDKN2C,CGREF1,CKAP4,CKM,COL1A1,CSF1R,CTSE,DAB2IP,DTX1,E2F8,EBF1,ECT2,EDEM1,EIF4EBP1,ENTPD1,EPB42,ESCO2,ESRRB,ETS1,FGD2,FKBP11,FLT3LG,FOXO1,FOXP3,GADD45A,GADD45B,GIMAP4,GLUL,GM2A,GPAM,Hmgn2 (includes others),ID2,IFI16,IKZF2,IL16,IL18R1,IL1RL1,IL2RA,IL2RB,IRF1,IRF4,IRF8,ITGA4,ITGB7,JUND,KIF11,KIF4A,KIT,KLF4,KLF6,LEF1,LMO2,MAF,MAL,MKI67,MSMO1,MYCN,MYOD1,MYOG,NCAPG,NDN,NEIL1,NFIL3,NR0B2,NR4A3,NR5A2,NRAP,NTRK2,OPTN,PDIA4,PGK1,PLCG2,PLK4,PLPP5,POLE4,PPARG,PPIA,PRC1,PRDM1,PRDX4,RARG,RASGRP2,RASSF4,RCBTB2,RXRA,SCN4A,SCX,SEC24D,SELENOP,SEMA3F,SEMA4A,SEMA7A,SNAI1,SOCS1,SOCS3,SPC25,TCEAL9,Tcf7,TFCP2L1,THY1,TMEFF1,TNFRSF25,TNFRSF8,TOP2A,TOX,TRAF5,TYMS,VIPR2,VSIR,WNT10B,ZBTB16 | 1238 (21) |
| HMGA1 | 3.90e-01 | transcription regulator | NA | -8.30e-01 | NA | 0.0e+00 | ACTA2,B2M,CAV1,CAV2,CCND1,CCND2,CD44,CDH1,COL1A1,COX6A2,CRYAB,CSK,CTSC,CTSH,DAB2,DHCR7,EGR1,FSTL1,HCK,IER3,IGF1,IGFALS,IGFBP4,IGFBP7,IL2RA,ITGAL,KCNJ11,KIT,KITLG,MIA,MVD,MVK,MYO1F,NECTIN1,PIGO,PPARG,PTGS2,RARA,SDC4,SEC24D,SERPINH1,SFXN1,SLC17A5,SNAI1,SPARC,SYK,TAGLN,TWIST1,VIM,WNT6,XPA,ZFP57 | 1527 (22) |
| FZR1 | 6.60e-01 | kinase | NA | -8.30e-01 | NA | 1.0e-02 | CCND1,HECW2,PFKFB3,RNF157,SGO1,SKP2 | NA |
| belinostat | NA | chemical drug | NA | -8.30e-01 | NA | 2.0e-02 | BCL2L1,BCL2L11,CDKN1A,ERCC1,MICB | NA |
| FABP4 | -3.70e-01 | transporter | NA | -8.30e-01 | NA | 2.0e-02 | ABCA1,Ccl2,CD36,LTB4R,MSR1,PPARD,PPARG,PTGS2,PYCARD,SOCS3 | NA |
| SH3TC2 | -1.39e+00 | other | NA | -8.30e-01 | NA | 0.0e+00 | AACS,ACSL1,DHCR7,EBP,EGR1,EGR2,LSS,MAG,MPZ,MVD,MVK,PMP22,PRX | NA |
| TAS4464 | NA | chemical drug | NA | -8.30e-01 | NA | 0.0e+00 | BCL2A1,BCL6,CDK2,CDKN1A,E2F2,EGR1,GADD45A,ITGAL,KLF6,PLK1,SUMO3,TIMP1,VIM | 1243 (11) |
| COLQ | -1.42e+00 | other | NA | -8.40e-01 | NA | 0.0e+00 | ADAMTS2,ADAMTS5,BDNF,BGN,BMP1,BMP4,CHRNA1,CHRND,COL11A1,COL2A1,COL5A2,COL6A3,COL7A1,COL8A1,DCN,ECM1,EXT1,FBLN5,FN1,LAMA4,LTBP1,MMP19,MMP2,MUSK,NID1,PRELP,PRIMA1,SDC4,SNTB2,SSPN,TGFB1,TIMP1,VCAN,WNT4 | NA |
| SIGLEC8 | -1.49e+00 | transmembrane receptor | NA | -8.40e-01 | bias | 0.0e+00 | BCL2A1,CD53,CLEC4A,CSTB,EEF1E1,FAM162A,FTL,HSPE1,MRPL54,NHP2,PGK1,PRDX1,RANBP1,RGS10,SCAND1 | NA |
| GH1 | NA | growth factor | NA | -8.40e-01 | NA | 0.0e+00 | ACVR1,ATF3,CDH2,CEBPD,CISH,CREB1,CUX1,CXCR4,EGR1,ERBB3,FN1,GADD45A,ID2,IGF1,IGFALS,ITGA1,MGST1,PRDX1,RETN,RHOA,RPL6,SNAI1,SOCS1,SOCS3,SPP1,SREBF1,STAR,TKT,TRPV1,TWIST2,UBA7,VIM,ZFP36 | 1394 (18) |
| TAFAZZIN | NA | enzyme | NA | -8.40e-01 | NA | 0.0e+00 | ACTA2,ADAMTS1,ADAMTS5,ADRB2,ADRM1,AEN,AHNAK2,ANKRD1,ANXA1,ANXA2,ANXA5,AOX1,ARG1,ARHGAP29,ARNT2,AVEN,AXL,BANK1,BCL2L11,BDNF,CASP3,CASP8,CAV1,CAV2,Ccl2,CCND1,CCRL2,CD180,CD22,CD44,CD86,CDH2,CDH6,CDK6,COL1A1,COL5A1,COL5A2,COPS7A,CXCL12,CXCR4,CYP1B1,CYTIP,DCN,DNASE1L3,DUSP1,EDN1,EGLN1,EGR2,EMCN,ESM1,F2RL1,FN1,GBE1,HIF1A,HLA-A,HLA-DQA1,Hmgn2 (includes others),HSP90AA1,HUS1,IDH1,IFI16,IFIT1,IGFBP4,IL16,IRAK2,IRF4,IRS1,ITGAL,KDM3A,KIT,KLF6,LCP1,LGR5,LOX,LOXL2,LUM,LY75,MET,MFAP5,MRC1,MYOF,NAV3,NCF4,PDE3B,PGM1,PIK3R1,PKM,PLK2,PLOD2,PPP1R3B,PRKCB,PSMA4,PSMA6,PSMB1,PSMC1,PTGS2,PTX3,RGS4,RNF213,RUNX2,SELP,SEMA3C,SERPINE1,SIPA1,SLC2A1,SORBS2,ST6GAL1,STAT1,TAGLN,TFPI2,TGFB1,THBS1,TIMP1,UBE2D3,UGDH,VCAM1,WNT11 | 1407 (17) |
| 8-bromoguanosine 3’,5’-cyclic monophosphate | NA | chemical reagent | NA | -8.40e-01 | NA | 0.0e+00 | ACTA2,ADAM10,CAV1,CDK14,CDKN1A,CNN1,EDN1,FOXP3,HINT1,INHA,S100A10,SLC12A4,SNAI1,TAGLN2,TGFB1,TRPC6,VCAM1 | 1544 (22) |
| HNRNPA2B1 | 2.00e-02 | other | NA | -8.50e-01 | NA | 0.0e+00 | ACSL5,ADGRG2,ATRX,BCL2L1,CA12,CACNB2,CDH1,CLDN1,CP,CRB1,CUX1,DDR1,DSE,ELOVL7,ENTPD1,ERBB3,EYA4,FHL1,FN1,FSCN1,GJC1,HYAL1,INHBB,LEPR,LETM2,LPAR1,MAST4,MFHAS1,NOVA1,NPR3,NR2F1,NRCAM,NTS,PDE1A,PDGFC,PGM2L1,PKIB,PKM,PLOD2,RIMKLB,RYR1,SEMA3B,SLC1A1,SNAI1,SNAI2,SRSF1,ST8SIA4,SVEP1,TFPI2,TLE1,TOX3,TWIST1,UBASH3B,UBXN10,UTRN,VCAN,WNT4,ZC3HAV1 | 731 (7) |
| PRKCB | -9.30e-01 | kinase | NA | -8.50e-01 | NA | 0.0e+00 | ACTA1,BCL2L1,CCND1,CD83,CD86,CDKN1A,CLCN7,EGR1,FGF2,FN1,FOXO1,FOXO3,HIF1A,ICAM1,IGF1,IRS2,MMP2,MYH7,NR0B2,PFKFB3,PPP1R3C,PRKCB,PRKCD,PTGS2,SERPINE1,SREBF1,TGFB1 | 1204 (22) |
| IRAK4 | -5.00e-02 | kinase | NA | -8.50e-01 | NA | 0.0e+00 | ATF3,BIRC3,BTG2,Ccl2,CD86,CSRNP1,CXCL10,CXCL16,DAB2,EDN1,EGR1,ERRFI1,IRF1,IRF3,IRF4,IRF5,NFKBIA,NLRP3,NR4A1,OLR1,PHLDA1,PPARG,RASA2,SLC25A25,SOCS1,ZFP36 | 1142 (12) |
| CCR1 | -1.17e+00 | G-protein coupled receptor | NA | -8.50e-01 | NA | 1.0e-02 | Ccl2,CCR1,CTSK,CTSS,ITGB3,MMP2,RUNX2,SPARC,SPP1,VIM | NA |
| HHEX | -9.30e-01 | transcription regulator | NA | -8.50e-01 | NA | 0.0e+00 | ANKRD1,AXL,CX3CL1,CXCL10,ENG,FGF2,FOXP3,IL2RA,IL33,IL7,KDR,MYH10,NRP1,TEK,TNFSF8,WNT2 | NA |
| phosphate | NA | chemical - endogenous mammalian | NA | -8.50e-01 | NA | 0.0e+00 | A2M,ACTA2,ADAMTS2,AXL,CIT,CNN1,COL19A1,COL5A1,DCN,DUSP6,ECM1,ECSIT,EGR1,ETV5,F2R,GDF10,NCOR2,OGN,PKD2,RPL7L1,RUNX2,SLC20A1,SLC20A2,SPP1,SPRY4,TAGLN2,TGFB1,TIMP1,UQCR11,ZFP36L2 | 1232 (21) |
| MCM10 | 1.00e-01 | other | NA | -8.50e-01 | NA | 0.0e+00 | CDH1,SNAI1,TWIST2,VIM | NA |
| SLC2A11 | NA | transporter | NA | -8.50e-01 | NA | 3.0e-02 | ADIPOQ,DLK1,PPARG,PPARGC1B | NA |
| MFAP4 | NA | other | NA | -8.50e-01 | bias | 2.0e-02 | COL1A1,FN1,NFKBIA,SERPINE1,TGFB1 | NA |
| MGAT5 | -1.30e-01 | enzyme | NA | -8.50e-01 | NA | 1.0e-02 | AXIN2,CDH1,CDH2,ITGA5,LGR5,PROM1,PTPRC,SNAI1,TWIST1 | 1412 (20) |
| DCAF1 | 3.70e-01 | kinase | NA | -8.50e-01 | NA | 3.0e-02 | CDC25B,CDKN1A,CENPF,KLF10,PLK1,Pmaip1,PTGES,SOCS3,UCN | NA |
| Smad2/3 | NA | group | NA | -8.50e-01 | NA | 4.0e-02 | ACVR1,ACVR1C,CBFB,CDKN1A,CNN1,FAP,FOXP3,FUT7,GCNT1,HMCN1,RUNX1,RUNX2,S100A4,SERPINE1,SMAD7,TAGLN,TMEFF1,TNC,WNT10B | NA |
| mevastatin | NA | chemical drug | NA | -8.60e-01 | NA | 0.0e+00 | ABCA1,ADAMTS1,BMP4,CDKN1A,DHCR7,KLF4,NOS1,PTGS2,SREBF1 | 1567 (20) |
| LASP1 | -1.14e+00 | transporter | NA | -8.60e-01 | NA | 3.0e-02 | CDH1,ITGA4,S100A4,VIM | NA |
| RORC | NA | ligand-dependent nuclear receptor | NA | -8.70e-01 | NA | 1.0e-02 | ALDOA,Aox3,ARSG,ASNS,ATP1B1,B3GALT1,CD28,CD36,CISH,COL3A1,CYP39A1,CYP7B1,ELOVL7,FOXP3,GADD45B,GFPT2,GPI,GPT2,HIF1A,IDH3A,IDH3G,IL17A,IL17RA,IL1R1,IL2RA,IL4I1,MDH1,Mt1,NAT2,NLRP3,NNMT,PGK1,PKM,PPP1R3C,REL,RHBG,Scd2,SELENBP1,SLC16A7,SLC25A24,SLC2A13,SLC41A2,Slco1a4,SPARC,SULF2,UGGT2,ZBTB16 | 1301 (21) |
| IL15 | -3.30e-01 | cytokine | NA | -8.70e-01 | NA | 0.0e+00 | ACADS,ACTG2,ACTN4,AHR,ALDOA,ANXA1,APBA1,ARHGDIB,BAMBI,BCL2L1,BCL2L11,BPGM,BTG1,CAMK2D,CASP3,Ccl2,CCND1,CCND2,CCR1,CD226,CD244,CD28,CD44,CD53,CD74,CD83,CD84,CD86,CDH1,CDK6,CDKN1A,CEACAM1,CISH,CMKLR1,CORO1A,CSF1,CX3CR1,CXCL10,CXCL12,CXCR4,DPP4,DUSP11,DUSP5,EBP,EDN1,EGLN1,EGR2,ELK3,ENO2,ENO3,ETS1,FCGR3A/FCGR3B,FLT3LG,FOXP3,FYN,G6PD,GAPDH,GCNT1,GGT5,GNAS,GPD2,GPI,GZMB,H2AC18/H2AC19,HIF1A,HK1,HLA-DRA,HLX,HMCN1,HSPE1,ID4,IFIT1,IL15RA,IL17A,IL18R1,IL1R1,IL2RA,IL2RB,IL2RG,IRF1,ISG15,ITGB7,KIT,LEF1,LSR,LYN,LYPLA1,MAF,MAPK3,MICB,MKI67,MSLN,MX1,MYH2,NCAM1,NFIL3,NFKBIA,OAZ1,OGN,P2RY6,PDIA4,PFKFB3,PFN1,PGAM2,PGK1,PGM1,PIK3R1,PIK3R3,PKM,PLA2G4A,PLCG2,PLD1,PLEK,POLR2K,PPARD,PPARGC1B,PRDM1,PRDX4,PTP4A2,PTPRC,PTPRJ,PYGL,RAB8A,RAC2,S100A11,SERPINE1,SLC16A1,SLC16A3,SMAD7,SOCS1,SPN,TFDP2,TIMP1,TKT,TLR2,TNFRSF25,TNNI1,TNNI2,TOP2A,VCAM1,ZFP36,ZFP36L1 | 1256 (16) |
| conjugated linoleic acid | NA | chemical drug | NA | -8.70e-01 | NA | 0.0e+00 | AXL,BCL2L1,CALCR,CCR5,CST7,CTSK,CXCL13,CXCR4,DUSP1,FCGR2B,GCLC,IL10RA,IL10RB,IL1RN,ITGB2,NLRP3,PPARG,PPARGC1B,PRDX1,PTGS2,SOCS3,SRSF1,TNFRSF11B,TNFSF8,VEGFD,WNT10B | 1185 (15) |
| POU2F2 | -2.09e+00 | transcription regulator | NA | -8.70e-01 | bias | 1.0e-02 | ALOX5,ASB13,BANK1,BCL6,CCR5,CD22,CXCR5,DACT3,DHRS9,DIXDC1,EBF1,ELL2,GATM,GPR183,HLA-DRA,MCM7,MVK,PFKFB3,PFKFB4,POU2F2,RPS2,RYR1,SKP2,SPP1,TGFA,TNFAIP2 | 93 (3) |
| GAB2 | -2.00e-02 | other | NA | -8.70e-01 | NA | 1.0e-02 | ARG1,BCL2L1,Ccl2,CD34,CDH1,HIF1A,ITGA2B,ITGB3,KDR,SERPINE1,SMAD7,SPARC | NA |
| PLA2G6 | 4.20e-01 | enzyme | NA | -8.70e-01 | NA | 0.0e+00 | ALOX12,ARG1,BCL2L1,Ccl2,EIF2AK3,MRC1,NOX1,NOX4,PPARG,PTGS2,RGS2,RUNX2,STAT6 | 1134 (19) |
| GPR174 | -9.40e-01 | G-protein coupled receptor | NA | -8.70e-01 | NA | 0.0e+00 | ABCA1,ADD3,ARAP2,ARID5A,B3GNT7,BCL2L11,BCL3,CABLES1,CARD11,Ccdc50,CD180,CD200,CD22,CD86,CHST3,CIITA,CREM,CYBB,CYTH1,CYTIP,FYN,GPR171,HDAC9,IFI16,INPP5D,ITGAE,ITGB3,LITAF,LMO2,LRRC8D,MYO5A,NR4A1,P2RY10,PDE3B,PLK2,PTPN6,PTPRJ,RGS2,SIPA1L1,SLA,SLAMF1,ST6GAL1,SWAP70,TMEM123,TNFRSF1B,UGCG,VPS37B | NA |
| MAP4K4 | -4.70e-01 | kinase | NA | -8.70e-01 | bias | 0.0e+00 | ACADS,ACO2,ACSL5,AGL,AUH,BCAT2,Calm1 (includes others),CHSY1,FAR1,GLUL,GRHPR,H6PD,HSD3B7,ITGA5,LDHB,MAFA,NDUFAB1,NDUFV1,NKX6-1,NT5C2,PEX16,PGM1,PI4K2B,PIGO,PMM1,PNPLA3,POLE3,PON2,PPARG,PTGES,RPS6KB1,SREBF1,UCK1 | 1132 (13) |
| S1PR1 | -3.50e-01 | G-protein coupled receptor | NA | -8.80e-01 | NA | 0.0e+00 | BCL2L11,CCND1,HGF,ICAM1,IGF1,MAF,NLRP3,PTGS2,VCAM1 | 1299 (18) |
| MIF | NA | cytokine | NA | -8.80e-01 | NA | 0.0e+00 | ACTA2,ADGRE1,ADIPOQ,ARG1,BCL2L1,C3AR1,Ccl2,CCND1,CCR1,CCR5,CD44,CD84,CDC34,CHST10,COL1A1,CRP,CXCL10,CXCL16,CXCR4,DUSP1,F2R,F2RL1,GZMB,HAP1,HGF,HIF1A,ICAM1,IL15RA,IL16,IL17A,IL17RA,IL1R1,IL2RA,IL7,ISG15,ITGA4,MAP1LC3B,MET,MMP2,MYCN,OAS3,PTGS2,RETN,SOX6,SREBF1,STRA6,TGFB1,TGFBI,TIMP1,TLR4,USP18,VCAM1 | 1003 (13) |
| BCR-ABL1 | NA | fusion gene/product | NA | -8.80e-01 | NA | 0.0e+00 | BCL2A1,BCL2L1,BCL2L11,CAV1,CCND1,CD36,CDKN2C,CSF2RB,CSF3R,CXCR4,FYN,GAS2,HIF1A,HK1,IL2RA,ITGA2B,MME,MSR1,PDP2,PGK1,PIK3CG,PKM,PRKCB,PRKCD,PRKCI,SLC1A5,SLC2A1,SNAI2,SOCS1,TNFRSF10A | 1375 (20) |
| IL12 (family) | NA | group | NA | -8.80e-01 | NA | 2.0e-02 | ADAM19,ATF3,BCL2L1,BCL2L11,BCL3,BCL6,CASP3,CCR5,CD244,CD44,CD86,CXCR5,DDIT4,EGR2,ETV5,FCGR3A/FCGR3B,FOXP3,FUT7,GAPDH,GIMAP4,GMEB2,GZMB,IKZF2,IL17A,IL18R1,IL2RA,IRF1,IRF4,IRF8,LEF1,MAPK3,METRNL,NFIL3,NRP1,PTPRC,STAT1,TNFRSF25 | NA |
| TRIB3 | 3.00e-01 | kinase | NA | -8.80e-01 | NA | 3.0e-02 | ASNS,BCL2L11,DDIT4,FBXO32,HERPUD1,HIF1A,MTHFD2,PPARG,RUNX2,SLC2A1,TWIST1 | NA |
| TXNIP | 3.10e-01 | other | NA | -8.80e-01 | NA | 0.0e+00 | ALDOA,BCL6,CASP1,CCNA2,CCND1,CD36,CDKN1A,DDIT4,DHCR7,G0S2,G6PD,GAPDH,HIF1A,ICAM1,IDH1,IL2RB,LPL,NLRP3,NOX4,PGK1,PTGS2 | 1538 (22) |
| TP73 | 5.00e-02 | transcription regulator | NA | -8.90e-01 | NA | 0.0e+00 | ACTA2,ACTN2,ADAM10,ADAM17,ADAM19,AEN,AFAP1,AIF1L,ATF3,AUH,AXL,B2M,BAP1,BCAR1,BCL11B,BCL2L11,BDKRB2,BHLHE40,BTG2,C1R,C3,CAMLG,CASP1,CASP3,CASS4,Ccl2,Ccl6,CCNA2,CD83,CDC25B,CDH1,CDK2,CDK6,CDKN1A,CITED2,CNN3,COL18A1,COL1A1,COL5A2,COX4I1,CRYAB,CX3CL1,CXCL10,CXCR5,CYBA,DAB1,DBP,DCAF6,DDIT4,DRAM1,DUSP11,ECM1,EDN1,EGR1,Elob,ENG,ESRRB,FEN1,FGF2,FN1,FOXO3,G0S2,G6PD,GADD45A,GPNMB,GPR176,GRK5,HAPLN3,HIC1,HIF1A,HPSE,HSPA1A/HSPA1B,ID2,IER3,IGFBP4,IGFBP5,IL7,IQGAP1,IRF5,ITGA1,ITGA5,ITGA6,ITGB2,ITGB4,ITGB7,JAG1,KCNK1,KIF23,KIT,KLF5,KLHL21,LAMA3,LASP1,LBH,LCP1,LIMA1,LRG1,LTBP1,LZTS1,MAPK14,MCM7,MDK,MISP,MMP14,MMP19,MMP2,MMP28,MPZL2,MYCN,NCAM1,NLRC4,NRP1,PALLD,PDGFB,PDPN,PIEZO2,PIK3R3,PLK2,PMP22,PRAG1,PRKDC,PTGES,PTP4A3,PTPN3,RAB7B,RELN,RUNX1,SDC4,SERPINE1,SERPINF1,SERPING1,SHROOM4,SLC4A3,SMO,SNAI1,SNAI2,SORBS3,SPP1,STARD8,STMN1,TBX3,TBX5,TFCP2L1,TGFB1,THBS1,THBS2,THY1,TIMP1,TLE2,TNFAIP2,TNFRSF10A,TNFRSF1B,TNNI1,TSPAN1,TWIST1,UCN,VEGFC,WNK3,WNT4 | 1348 (16) |
| cigarette smoke | NA | chemical toxicant | NA | -8.90e-01 | NA | 0.0e+00 | ABCA1,ACTA1,ADH7,AHR,AOX1,AXIN2,BCL2L1,C3,Ccl2,CCND1,CDKN1A,CXCL10,CYP1B1,DDIT4,EGR1,EIF2AK3,ELN,EMCN,FBXO32,FN1,FOXO3,FTL,G6PD,GADD45G,GCLC,GPX3,GSR,HAS3,HLA-DRA,ICAM1,IGF1,IKBKB,IRAK2,KDR,KLF4,LAMP2,LRAT,MAFF,MAP1LC3A,MAP1LC3B,MAPK14,MMP2,MX1,NFE2L2,NFKBIA,NOX4,OAS3,OASL,Oasl2,P2RY6,PDGFB,PDK2,PRDX1,PRDX4,PRDX5,PTGES,PTGS2,PTPRB,PYCARD,REL,SERPINE1,SLC1A4,SLC2A1,SLC6A9,SMAD7,SREBF1,THY1,TIMP1,TLR4,TRIM63,UBC,UGDH,USP19,WNT5A | 1496 (20) |
| Cdk | NA | group | NA | -8.90e-01 | bias | 0.0e+00 | CXCL10,DDIT4,DUSP1,Esrra,FADD,GADD45A,GADD45G,IDH3A,MYCN,NEDD9,PHLDA1,PLEKHF1,RGS2 | 1222 (10) |
| 9,10-dimethyl-1,2-benzanthracene | NA | chemical toxicant | NA | -8.90e-01 | NA | 0.0e+00 | AHR,ARG1,BCL2L1,CCDC80,CCND1,CDH1,CDKN1A,CYP1B1,EGF,EPHX1,GADD45A,GCLC,HGF,HRAS,MRC1,PTGS2,REL,RUNX1,SERPINE1,SNAI2,TGFA | 1294 (15) |
| BRCA1 | -2.00e-01 | transcription regulator | NA | -8.90e-01 | NA | 0.0e+00 | AK1,ALDH1A3,ANXA8/ANXA8L1,APOBEC1,ATP11C,BACH1,BCL2L1,BRCA2,CCND1,CDH3,CDKN1A,COL18A1,CYP1B1,DDIT4,EGR1,ELAVL1,EZR,FEN1,FHL2,FKBP5,FOXO1,FOXO3,GADD45A,GADD45B,IFIT1,KIT,LAMA3,LPIN1,MX1,NEDD9,NFE2L2,PHLDA1,PLK1,PLTP,Ptprv,RBL1,SAFB,SNAI1,SNAI2,STAT1,STAT5B,TNFAIP2,TP63,TWIST1,VCAN,VIM,WEE1 | 1493 (18) |
| PLCB1 | -1.21e+00 | enzyme | NA | -9.00e-01 | NA | 0.0e+00 | CDH1,CDH2,GAPDH,MAPK3,MYOG,PTGS2,VIM | 1351 (16) |
| NFIA | -1.60e-01 | transcription regulator | NA | -9.00e-01 | NA | 2.0e-02 | CDH2,CSF1R,LOX,MYF6,MYH2,MYL1,RGN,RP2,RUNX2,TNFSF18 | NA |
| KLF8 | -6.40e-01 | transcription regulator | NA | -9.00e-01 | NA | 3.0e-02 | CCND1,CDH1,EPSTI1,MMP14 | NA |
| rhein | NA | chemical - endogenous non-mammalian | NA | -9.00e-01 | NA | 1.0e-02 | BCL2L1,CASP3,CCR1,OCLN,SREBF1,VCAM1 | 1085 (14) |
| ACTN4 | -7.00e-01 | transcription regulator | NA | -9.00e-01 | NA | 1.0e-02 | CCND1,DCN,MYCN,PDLIM1,RHOA,SERPINE1,SNAI1,WNT5A | NA |
| doramapimod | NA | chemical drug | NA | -9.00e-01 | NA | 2.0e-02 | CCND1,CDK2,HAS2,MYH7,TLR2,TP63 | NA |
| INPP4B | -1.40e+00 | phosphatase | NA | -9.00e-01 | NA | 2.0e-02 | AXIN2,LEF1,MYCN,NNMT,SYTL2,TMPRSS2 | NA |
| RHOB | 3.80e-01 | enzyme | NA | -9.00e-01 | NA | 4.0e-02 | CDKN1A,ICAM1,ITGB2,ITGB3,PTGS2,RHOA | NA |
| NOTCH1 | 9.00e-02 | transcription regulator | NA | -9.00e-01 | NA | 0.0e+00 | ACTA2,ADAM19,ALDH1A1,ALDOA,ANKRD1,BCL2L1,BCL6,BIRC3,CCND1,CCND2,CD44,CD84,CDH1,CDH2,CDK2,CDKN1A,CEBPD,CKM,CNN1,COL1A1,CSF1R,CSF2RB,CXCR4,DLK1,DLL1,DNAJA1,DTX1,ECT2,ENO2,EPHA4,ERBB3,ESM1,FCER1G,FCGR2B,FGF2,GFAP,GLI1,GLI2,HBA1/HBA2,HEY2,HIF1A,HSPE1,ICAM1,ID2,IFI16,IGFBP4,IL17A,IL2RA,IRF1,IRF8,ITGA2B,ITGA6,ITGB4,JAG1,LEF1,LOX,mir-143,MMP2,MPZ,MYCN,MYH7,NCF1,NCF4,NDUFV2,NR2F2,NRARP,PDGFB,PFKFB3,PGK1,PKM,PPARG,PRAG1,PROX1,PTGS2,REL,RND3,RUNX2,SCN5A,SELE,SERPINE1,SLC2A1,SNAI1,SOCS1,SOX10,SPP1,SYP,TAGLN,TEK,TGFB1,TP63,TSPAN33,TWIST1,WNT4,WNT5A | 1473 (16) |
| GAS5 | NA | other | NA | -9.00e-01 | NA | 5.0e-02 | ACTA2,CASP3,CCND1,CDK6,FGF1,PPARD,RECK | NA |
| Secretase gamma | NA | complex | NA | -9.00e-01 | NA | 0.0e+00 | BATF,CD83,CD86,CDH1,DTX1,HEY2,IL17A,IL2RA,MME,PTPRF,RELN,SLC16A1,SLC2A1 | 1445 (19) |
| OSCAR | -3.00e-02 | other | NA | -9.00e-01 | NA | 2.0e-02 | CCL24,CD83,CD86,CX3CR1,FZD2,ICAM1,IL1R1,IL1RN,MMP19,TLR7,TLR8 | NA |
| AGRN | -2.60e-01 | other | NA | -9.00e-01 | bias | 5.0e-02 | BMP4,MAP1B,MAP2,UTRN | NA |
| SKI | 5.20e-01 | transcription regulator | NA | -9.10e-01 | NA | 0.0e+00 | ACTA2,BCL11B,CDH1,CDKN1A,FAP,GLI1,MITF,MPZ,MYOG,NRCAM,PAX3,PMP22,PRX,SERPINE1,SMAD7,ZEB2 | 1278 (23) |
| PPARG | -1.07e+00 | ligand-dependent nuclear receptor | NA | -9.10e-01 | NA | 0.0e+00 | ABCA1,ABCG1,ACADL,ACADS,ACOT8,ACSL1,ACSL5,ACTA2,ADIPOQ,ADRB2,AGPAT2,ALDH9A1,ALOX12,AQP7,ARG1,ATP2A2,BCL2L1,BCL6,BDH1,BIN1,C3,CAV1,CAV2,Ccl2,CCND1,CD36,CDH1,CDK2,CDK6,CDKN1A,CDKN2C,COL1A1,CREB1,CXCL14,CYBA,CYP4B1,DLK1,EDN1,EGLN1,EIF4EBP1,ENO2,EPHX1,ETS1,FABP1,FAM20C,FBP2,FGF1,FN1,FZD1,GAPDH,GPAM,GPD1,H6PD,HCAR1,HCAR2,HEBP1,HGF,HSD3B7,ICAM1,IDH1,IGF1,IGFBP5,IGFBP6,IGFBP7,IL17A,IL2RA,IL33,IRS1,IRS2,ITGAD,Kctd12b,KLF4,KLF6,KRT19,LPL,MAP2,MBNL1,MCM7,MCTP1,MDH1,MGST1,MKI67,MMP14,MRC1,MVD,MYF5,MYF6,MYH14,MYH7,MYOD1,MYOG,NCF1,NFE2L2,NOX1,NOX4,NPR3,NR2F2,NR4A1,OCLN,OLAH,OLR1,PC,PCTP,PDE3B,PDK4,PEA15,PEX6,PFKFB3,PHKB,PLA2G2A,PLIN1,PLIN3,PLIN4,PMM1,PPARD,PPARG,PPARGC1B,PPIC,PPP2R2B,Ppp2r3d,PRDM1,PRKG2,PTGER3,PTGES,PTGS2,PTPRF,PYGL,RETN,RGL1,RUNX2,SCNN1G,SDC1,SELE,SERPINE1,SFTPB,SGK1,SLC27A1,SLC27A3,SLC2A1,SLC44A1,SLC9A1,SMO,SOCS1,SOCS3,SPP1,SREBF1,STAR,STAT5B,TAGLN,TBCC,TBXAS1,TKT,TLR4,TRERF1,TUBB,UCK1,UCP3,VAMP5,VCAM1,VIM,VSIR,WIPF1,XYLT1 | 1429 (22) |
| GPER1 | 9.00e-02 | G-protein coupled receptor | NA | -9.10e-01 | NA | 0.0e+00 | ACTA2,ATF3,BHLHE40,CACNA1D,CCND1,CDKN1A,CEBPD,DDIT4,DUSP1,DUSP5,EDN1,EGR1,ERRFI1,FAP,IGF1,MYH10,NFKBIA,NR4A2,RND1,SFRP2,SLC1A1,SLC2A1,TAGLN,USP19,ZFP36 | 1862 (18) |
| GFI1B | -5.10e-01 | transcription regulator | NA | -9.10e-01 | NA | 3.0e-02 | ALDH9A1,BCL2L1,CDKN1A,CSDE1,ELF4,FOXO1,SOCS1,SOCS3 | NA |
| C3AR1 | -1.19e+00 | G-protein coupled receptor | NA | -9.20e-01 | NA | 3.0e-02 | C3,Ccl2,CD28,CD86,COL1A1,CXCL10,DCN,GULP1,IGF1,IL17A,LTBP1,LTBP2,SERPINE1,SREBF1 | NA |
| CFB | -6.70e-01 | peptidase | NA | -9.20e-01 | NA | 4.0e-02 | ACTA1,ACTC1,ADIPOQ,ARG1,C3,C3AR1,C5AR1,MYH6,SREBF1,THBD | NA |
| methamphetamine | NA | chemical drug | NA | -9.20e-01 | NA | 0.0e+00 | ADGRE1,ALDH18A1,ALOX15,BCL2L1,BDNF,CARMIL1,Ccl2,CCL21,CREM,EGR1,ELF1,FOXRED2,GBP2,GDA,GFAP,HOMER2,ICAM1,JUND,KLKB1,LGALS1,MAP3K6,MATN2,MMP2,MRC1,NAT8L,NDUFB3,NR4A1,NTRK2,NTS,OCLN,PDZD3,PITX3,PPP3CA,PTCH1,PTPN12,RRH,SLC18A2,STAT6,TNFRSF1B,TPH1,UGT8,VCAM1 | 1435 (20) |
| ACSL4 | 3.00e-02 | enzyme | NA | -9.20e-01 | NA | 0.0e+00 | AUTS2,CALCR,CAMK1D,CAMK2D,Ccl2,CDC25B,COL12A1,DLC1,DOCK5,ERCC1,GDPD1,ICAM1,MYO5A,PPARG,PTGS2,SELENOM,SERPINF1,SPP1,STAT1,THBD | 1203 (18) |
| LINC00887 | NA | other | NA | -9.30e-01 | NA | 0.0e+00 | CA9,CDH1,CDH2,VIM | 1006 (7) |
| NSD3 | -1.00e-02 | enzyme | NA | -9.30e-01 | NA | 1.0e-02 | CCND1,CDH1,CDH2,VIM | 716 (7) |
| HSPA5 | -9.00e-02 | enzyme | NA | -9.30e-01 | NA | 2.0e-02 | BCL2L1,CASP3,CD47,CDH1,CRTC1,CXCL10,EIF2AK3,GATA4,GRIA2,IFIT1,ISG15,MAG,MAP1LC3B,PLP1,SREBF1 | NA |
| methyl methanesulfonate | NA | chemical toxicant | NA | -9.30e-01 | bias | 0.0e+00 | ADGRB3,ARFGAP3,ATF3,BTG1,BTG2,CDH1,CDKN1A,EGR1,GADD45A,GADD45B,GADD45G,HERPUD1,KLF4,NFYA,NMI,SNAI1,ST14,VIM | 1594 (21) |
| NFAT (complex) | NA | complex | NA | -9.40e-01 | NA | 0.0e+00 | AIF1,ATF3,CD86,CYGB,F3,ICAM1,IL33,NR4A1,SERPINE1,SLC1A3,SPP1 | NA |
| SRD5A2 | 1.00e-01 | enzyme | NA | -9.40e-01 | bias | 2.0e-02 | CREB1,IRS2,LPL,Mt1,SOAT1 | NA |
| MAEL | NA | transcription regulator | NA | -9.40e-01 | bias | 2.0e-02 | CD44,KLF4,PROM1,PTGS2 | NA |
| SYNCRIP | NA | other | NA | -9.40e-01 | NA | 0.0e+00 | CDH1,CDH2,FN1,RHOA,SNAI1,VIM,ZEB2 | 1115 (13) |
| 5-N-ethylcarboxamido adenosine | NA | chemical reagent | NA | -9.40e-01 | NA | 0.0e+00 | ACKR3,ADORA2A,ARG1,BCL3,BHLHE40,BTG2,Ccl2,CDH2,CEBPD,CIITA,CREM,CSF2RB,DAD1,EGR1,EGR2,FGF2,FZD1,GADD45A,GCLC,HIF1A,HLA-DQA1,HLA-DRA,INHBA,KCNA2,KLF6,NFIL3,NR4A1,NR4A2,NR4A3,NRP1,PDE5A,PLK2,PROM1,RGS2,SERPINE1,SNAI1,SOCS3,ST3GAL1,TGFB1,THBD,THBS1,UBC,VCAN,VIM | 1145 (15) |
| RND3 | -1.10e+00 | enzyme | NA | -9.40e-01 | NA | 0.0e+00 | CCND1,CDH1,CDKN1A,FN1,HEY2,HIF1A,MMP2,PTGS2,ROCK1,VIM | 1339 (17) |
| CRNDE | NA | other | NA | -9.40e-01 | NA | 0.0e+00 | BCL2L1,CDKN1A,DUSP10,DUSP5,DUSP6,GAB1,GADD45B,IL1R1,NR4A1,RAC2,RASGRP2,STK3,TGFB1 | 1260 (15) |
| FGFR2 | -7.10e-01 | kinase | NA | -9.40e-01 | NA | 0.0e+00 | BMP4,CCND1,CCND2,CDH1,CDH11,CDKN1A,CLIC6,COL1A1,COL3A1,CTSC,CTSH,DAB2,DLL1,DRAM1,ENPEP,FGF10,FLRT3,FN1,GPT2,HRAS,ICAM1,ID2,IGF1,INHBB,LGR5,MRAS,MYO1F,NR5A2,PCOLCE,PDGFRA,PITX2,PLP1,RUNX2,SFRP1,SNAI1,SOX7,SPP1,TSPAN8,VCAM1,VEGFC | 1662 (21) |
| WNT5A | -7.60e-01 | cytokine | NA | -9.50e-01 | NA | 0.0e+00 | ALDH1A1,ARG1,ARHGDIB,AXIN2,BCL2L1,BIN1,BMP3,BMP4,BTG2,CCND1,CD34,CD36,CDH1,CDK6,COL1A1,COL2A1,CRYAB,CXCL10,CXCL12,CXCR4,CYB5R2,DAB2,DAB2IP,DBNL,DLL1,DOK2,EPHA4,F2R,FLNA,FN1,FZD4,FZD5,GAB1,GCNT2,GREM1,HDAC7,ID2,IKBKB,INHBB,IRF1,IRF8,ITGA4,ITGB3,ITGB7,KIT,LAMA3,LCP1,LONRF2,MMP14,MYF5,MYOD1,NR0B2,NR5A1,NRK,PITX3,PKN1,PRKCI,PROM1,PRSS12,PTGS2,RET,RUNX2,SDC1,SDC4,SEMA3E,SIAH2,SNAI1,SOCS3,SPARC,SPP1,STAR,STAT1,SYK,TGFB1,TLR4,TLR5,TWIST1,VIM,ZEB2,ZNF385B | 1535 (18) |
| tert-butyl-hydroquinone | NA | chemical reagent | NA | -9.50e-01 | NA | 0.0e+00 | AGL,ATF3,BACH1,CNR1,DDAH1,DDAH2,FLRT2,FOXC1,FTL,G6PD,GADD45A,GBE1,GCLC,GSR,Gsta4,HERPUD1,ICAM1,IL2RA,MAF,MAP1A,MAP2K4,NFE2L2,PALLD,PHKA1,PPARG,RASSF2,SERPINE1,SLC1A1,SNTB2,WNT5A,ZFP36L2 | 1366 (18) |
| IRS1 | -1.40e+00 | enzyme | NA | -9.50e-01 | NA | 0.0e+00 | ACTC1,ADIPOQ,BUB1,CCND1,CDH1,CDKN2C,CEBPD,COL3A1,COL6A3,COL7A1,DBN1,DBNL,DLK1,EGR1,Esrra,FBXO32,FEN1,FHL1,GAS2,GLRB,ID2,IGF1,IGFBP4,IRS1,IRS2,KLF4,LAMA4,LPL,MMP14,MYL1,MYOCD,NDN,NR2F1,NRP1,PAX3,PIK3R1,PLPP3,PPARG,PPARGC1B,PRDM16,PTPRF,SFRP2,SNAI1,SNAI2,SPP1,SREBF1,TAGLN,Tcf7,TGFBI,TNNC1,TNNI1,TNNT2,TRIM63,TRPC3,UCK1,UCP3,WNT5A,WNT6 | 1446 (20) |
| CD200R1 | -7.20e-01 | transmembrane receptor | NA | -9.50e-01 | NA | 0.0e+00 | ATF3,BATF,CCR1,CCR5,CSF2RB,CXCL16,EGR1,ETS1,HIF1A,IL2RA,IL2RB,IL2RG,JUND,KIF11,KIF1C,KIF23,NFKBIA,RBL1,Sp100,TNFRSF25 | 1170 (19) |
| CALCA | NA | other | NA | -9.50e-01 | NA | 0.0e+00 | ADD3,ALDOA,AQP4,ARG1,BATF,CALCR,CD44,CD83,CD86,CGNL1,COL3A1,CREM,CSF2RB,CTSK,CXCR4,CYBA,EDN1,ENTPD1,ETS1,FA2H,FAR1,FGL2,FOXP3,GADD45B,GFAP,GPR65,HIF1A,ICAM1,ID2,IER3,IGF1,IL1RL1,IL2RA,IL2RB,IL4I1,IRF5,JAG1,KDR,LGALS1,LIMA1,MAX,MKI67,MME,NFIL3,NFKBIA,NR4A1,NRP1,P2RY1,PALM,PDLIM1,PHLDB2,PPARG,PPP1R1A,PRDM1,PRIMA1,RAB7A,RAP1GAP,RUNX2,SDC4,SERPINB9,SERPINE1,SLC9A3,SNX3,SORT1,ST14,TGFA,TPH1,TRPV2,ZEB2 | 1376 (16) |
| Stat5 dimer | NA | complex | NA | -9.50e-01 | NA | 0.0e+00 | BCL2L1,BCL6,BIRC3,CCND1,CCND2,CXCR5,EBF1,IGF1,IGFALS,SOCS1,SOCS3,TLR2 | NA |
| Stat6 dimer | NA | complex | NA | -9.50e-01 | NA | 3.0e-02 | ANO1,ARG1,BCL2L1,CD36,DUSP1,IRF4,KLF4,PPARD,PPARG,SOCS1,SREBF1 | NA |
| ammonium | NA | chemical - endogenous mammalian | NA | -9.60e-01 | NA | 0.0e+00 | ACSF2,ACTA2,ANKRD34A,APOBEC1,ARHGAP33,ATP1A1,BCL2L11,CAMK2D,CD200,CD44,CSRP3,DENND2D,DYNLL1,FAM162A,FHL3,FITM1,FKBP11,G0S2,HSD17B8,HSPE1,KLF15,LAMTOR2,LUZP1,MYBPC2,MYBPH,MYH7,MYO18A,MYOF,NCAM1,NEK9,PDLIM1,PSMC5,RCSD1,RHOA,RPL6,RRP9,S100A4,SGCA,SLC38A2,SLCO4A1,SLIRP,SORCS2,SPARC,STBD1,TBCA,TST,TTC30B,TWF1,UGDH,VAT1,WDR5B,ZEB2,Zfp429 (includes others) | NA |
| dinoprost | NA | chemical - endogenous mammalian | NA | -9.70e-01 | NA | 0.0e+00 | ATP1A1,ATP2A2,CCND1,CCND2,CD36,EDN1,FGF2,HSPA1A/HSPA1B,ID2,IL2RA,LPL,MGST1,NFIL3,NOX1,NR4A1,NR4A2,PDIA4,PLA2G4A,PTGFR,PTGS2,PTX3,RUNX2,SCN1B,SPP1,STAR,TGFA,TGFB1,THBS1 | 1401 (20) |
| BCL2L11 | -1.64e+00 | other | NA | -9.70e-01 | NA | 2.0e-02 | ADRB2,BCL2L11,CASP3,Ccl2,CCND1,CD36,CD84,HDAC9,TGFB1 | NA |
| ADCYAP1 | 1.20e-01 | other | NA | -9.70e-01 | NA | 0.0e+00 | ADD3,ARHGEF25,BDNF,Bex2/LOC100912195,BTG2,CCBE1,Ccl2,CCNA2,CCNI,CD86,CEBPD,CFL1,CNN3,COL3A1,COL5A1,COL5A2,CREB1,CXCL10,DDHD1,EDIL3,EFHC1,EGR1,EGR2,EGR3,ELAVL1,EMB,GALNT7,GAP43,GFAP,GLI1,GPC3,GREM2,GRK5,HK1,Hmgn2 (includes others),IER3,IRF1,IRF3,KIF23,LMO1,LUM,MAN1A1,MAPK4,MME,MOG,NFKBIA,NOS1,NPR3,NR5A1,NTRK2,PDE10A,PLAGL1,PNMT,PPP1R3B,RGCC,S100A10,SERPINF1,SLC18A2,SLC1A3,SLC2A1,SMPDL3B,SOCS3,SPARC,TENM2,TFPT,TGFBI,TGM4,TMSB10/TMSB4X,TTYH1 | 1449 (20) |
| n-3 fatty acids | NA | chemical drug | NA | -9.70e-01 | NA | 5.0e-02 | ADIPOQ,ALOX5,FADS1,FADS2,IRS1,IRS2,PDGFB,PIK3R1,PPARG,PTGS2,RGN,SDC1,SREBF1 | NA |
| MAPKAP1 | 2.70e-01 | other | NA | -9.80e-01 | NA | 0.0e+00 | CXCL10,CXCR4,DAPK1,FOXP3,HIF1A,IFI16,Slfn2,SNAI1,SREBF1 | 1377 (24) |
| baicalin | NA | chemical - endogenous non-mammalian | NA | -9.80e-01 | NA | 0.0e+00 | BDNF,CASP3,COL1A1,EGF,FOXP3,IGFBP5,KCNJ13,LCAT,MDK,MGST1,SPARC,TAGLN,TLR2,TLR4,TNFRSF11B,VIPR2 | 672 (14) |
| BANCR | NA | other | NA | -9.80e-01 | bias | 2.0e-02 | CCND1,CDKN1A,MMP2,TSHR | NA |
| TNFSF12 | 3.20e-01 | cytokine | NA | -9.80e-01 | NA | 0.0e+00 | ANKRD2,BCL2L1,Ccl2,CCL24,Ccl7,CCND1,CCR1,CCR5,CSF2RA,CXCL10,CXCR5,DLL1,FBXO32,ICAM1,IL17A,KLF15,MAP3K14,mir-133,MYOD1,MYOG,NCF4,NFKBIA,NOS1,PGAM2,PTX3,SELE,SIX1,SIX2,TIMP1,TRIM63,VCAM1 | 1119 (16) |
| REN | NA | peptidase | NA | -9.80e-01 | NA | 0.0e+00 | ADD3,APLN,CD86,COL3A1,F3,FGF2,ICAM1,MYH6,MYH7,NOX1,NOX4 | 1427 (19) |
| ITGB1 | -2.60e-01 | transmembrane receptor | NA | -9.80e-01 | NA | 0.0e+00 | ACTA1,ACTA2,ADAM17,ADAM19,ADAMTS2,ADAMTS5,AMIGO2,BCAN,BMP1,Ccl2,CDH1,CDH2,CDKN1A,COL19A1,COL1A1,COL27A1,COL5A2,COL7A1,CXCL10,EIF4EBP1,FBN2,FGF1,FLNA,FN1,FOXO1,FOXO3,GBP2,GDF6,GFAP,Ggta1,HAS3,HLA-A,ICAM1,IL17A,IL1RN,ITGA1,ITGA3,ITGA5,ITGA9,ITGB3,ITGB4,ITGB7,LIMS1,LOX,LOXL1,MATN2,MMP15,MMP19,MMP2,OLFML3,OTOG,PTGS2,RAC2,RELN,SERPINE1,SNAI1,SPON1,TGFB1,THBS1,VIM,WNT5A,WNT9A | 1499 (23) |
| NRIP1 | 9.00e-02 | transcription regulator | NA | -9.90e-01 | NA | 1.0e-02 | ACO2,CCND1,CD36,CDKN1A,Cox8b,CYP4B1,HAS2,IDH3A,LDHB,PDK2,PDK4,PPP1R3B,PTGS2,PTX3,PYGL,SLC36A2,SMAD6,STAR,SUOX,TNFAIP6 | 1833 (24) |
| SSTR2 | -3.10e-01 | G-protein coupled receptor | NA | -9.90e-01 | NA | 2.0e-02 | CDH1,CDH2,HDC,LPL,PYGL,SLC18A2,THBS1,TNFRSF10A,VIM | NA |
| ITGB3 | -1.54e+00 | transmembrane receptor | NA | -9.90e-01 | NA | 0.0e+00 | BCL2L1,CD36,CEACAM1,COL1A1,CSF1,FN1,HAS2,ITGA2B,ITGA3,ITGA5,ITGB3,KDR,LIMS1,MMP14,MMP2,NDUFV1,PTGS2,RHOA,RUNX1,RUNX2,SELP,SERPINE1,SMAD7,SNAI2,SNRPA,SPARC,TGFB1,TIMP1 | 1308 (20) |
| PDGF-AA | NA | complex | NA | -9.90e-01 | NA | 0.0e+00 | ACTA2,BDNF,CDKN1A,FGF2,GFAP,HGF,ID4,IGF1,PDGFRA,TGFB1,VIM | 1424 (19) |
| TNFAIP2 | -7.90e-01 | other | NA | -1.00e+00 | bias | 0.0e+00 | CITED2,FGL2,IL15RA,IRF1,PLAT,RBL1,RILPL1,SLCO3A1,VIM | NA |
| BAALC | -8.60e-01 | other | NA | -1.00e+00 | NA | 0.0e+00 | CDH1,CDH2,SNAI2,TWIST1 | NA |
| RHOV | -1.06e+00 | enzyme | NA | -1.00e+00 | NA | 0.0e+00 | CDH1,CDH2,SNAI1,SNAI2 | 1028 (10) |
| BP-1-102 | NA | chemical reagent | NA | -1.00e+00 | NA | 0.0e+00 | BCL2L1,ICAM1,IL17A,IL1RN,NFIL3,TGFA | 885 (10) |
| MEF2 | NA | group | NA | -1.00e+00 | NA | 1.0e-02 | CKM,IL1RN,LDHB,MB,MEOX2,mir-133,MYOCD,MYOG,NR4A1,PTGS2,RGS2,STAR | 873 (11) |
| Snhg16 | NA | other | NA | -1.00e+00 | NA | 1.0e-02 | ACTA2,CDH1,FN1,NOTCH2 | NA |
| SNHG29 | NA | other | NA | -1.00e+00 | NA | 1.0e-02 | CDH1,CDH2,SNAI2,TWIST1 | NA |
| STX2 | 1.50e-01 | transporter | NA | -1.00e+00 | NA | 1.0e-02 | BMP4,CCND1,MMP2,SMAD7 | 1323 (15) |
| EIF5A2 | -1.25e+00 | translation regulator | NA | -1.00e+00 | NA | 1.0e-02 | CDH1,CDH2,TGFB1,VIM | 678 (9) |
| alpha-hydroxyglutarate | NA | chemical - endogenous mammalian | NA | -1.00e+00 | NA | 1.0e-02 | CDH1,FN1,VIM,ZEB2 | NA |
| OVOL1 | -2.20e-01 | transcription regulator | NA | -1.00e+00 | NA | 3.0e-02 | CBFA2T3,GLI2,IRF6,TAF1C | NA |
| WNT7B | -9.40e-01 | other | NA | -1.00e+00 | NA | 3.0e-02 | AXIN2,CCND1,PTCH1,RUNX2 | NA |
| bicuculline/dalfampridine | NA | chemical reagent | NA | -1.00e+00 | bias | 3.0e-02 | ATF3,CUX2,HOMER1,PLXNA4 | NA |
| DGAT1 | 3.40e-01 | enzyme | NA | -1.00e+00 | NA | 4.0e-02 | CD36,LPL,PDK4,PNPLA2,PPARD,PPARG | NA |
| tryptase | NA | group | NA | -1.00e+00 | NA | 5.0e-02 | CXCL10,F2R,F2RL1,PLAT | NA |
| MED15 | 1.70e-01 | transcription regulator | NA | -1.00e+00 | bias | 5.0e-02 | CCND1,CDKN1A,KCNK1,LIMA1 | NA |
| HMMR | 3.20e-01 | transmembrane receptor | NA | -1.00e+00 | NA | 5.0e-02 | CDH1,CDH2,FN1,VIM | NA |
| miricorilant | NA | chemical reagent | NA | -1.00e+00 | NA | 5.0e-02 | CD36,FABP1,FKBP5,SREBF1 | NA |
| Ngf | NA | group | NA | -1.00e+00 | NA | 0.0e+00 | ANXA2,BCL2L11,BDNF,CALB1,CCND1,CDKN1A,DUSP1,EGR1,ENO2,FGF2,FGFR1,MAP1A,MAP2,NCAM1,NOS1,NR4A1,NR4A2,SERPINE1,SLC12A4,TGFB1,THY1,TRPV1,TTLL7 | 1274 (17) |
| ITGB2 | -7.80e-01 | transmembrane receptor | NA | -1.01e+00 | NA | 0.0e+00 | ACTA2,BCL2A1,BCL2L1,Ccl2,CD44,CD86,CXCL10,FN1,GADD45B,ITGA4,ITGAL,PTGS2,RAC2,RHOA,RUNX2,TGFB1,VCAM1 | 922 (18) |
| BCL2L1 | 1.12e+00 | other | NA | -1.01e+00 | NA | 2.0e-02 | BCL2L1,CASP3,Ccl2,CD44,ECM1,FN1,GFAP,GSR,ITGA3,MAP2,NOS1,PTPRC,SPN,THBS1,TIMP1,TNFRSF10A,TNFRSF11B,TNFSF8 | NA |
| telmisartan | NA | chemical drug | NA | -1.02e+00 | NA | 0.0e+00 | ACSL1,ADIPOQ,APLN,APLNR,BDNF,CASP3,CLEC4M,HGF,ICAM1,LPL,MRC1,NR4A2,OCLN,PLA2G5,PLIN1,PPARD,PPARG,PTGS2,TGFB1,TRPC3 | 1314 (21) |
| lovastatin | NA | chemical drug | NA | -1.02e+00 | NA | 0.0e+00 | ABCA1,ADAM10,ADAMTS1,ADIPOQ,ATF3,BCAR1,BCL2L1,BDNF,CCNA2,CCND1,CD86,CDKN1A,CIITA,COTL1,CXCL10,CYP4F2,DHCR7,DPYSL2,ENC1,ENO2,FGF9,FGFR1,GAP43,GFAP,GPX3,HBA1/HBA2,IGF1,IRF1,KLF4,MAG,MAL,Mbp,MKI67,MOG,MPZ,MVD,MVK,NFKBIB,NOX4,PIK3R3,PLAT,PLP1,POLG,PPARD,PTGS2,RBL1,RHOA,SDC4,SERPINE1,SLC16A7,SREBF1,TAGLN2,TGFB1,TNFRSF11B,TNFRSF8,VWF | 1279 (17) |
| NLRP3 | -9.30e-01 | other | NA | -1.02e+00 | NA | 0.0e+00 | ACTA2,ARG1,CAMK2A,CASP1,Ccl2,CCL24,CCR3,CCR5,CD1D,CD226,Cd33,CDH1,CDK2,CTSK,CXCL10,ESPL1,FN1,FOXP3,HIF1A,HLA-DQA1,IFITM3,IL17A,IL17RA,IL33,IRF1,IRF3,KIF1A,MRC1,MSR1,NFE2L2,Nlrp1a,NLRP3,OLR1,PRKDC,PTGS2,RUNX1,SMAD7,STAT1,TACC2,TGFB1,TIMP1,TYMS,VIM | 1191 (13) |
| PROCR | -1.50e-01 | other | NA | -1.02e+00 | NA | 0.0e+00 | ANGPT2,Ccl2,CCND1,GBP2,GBP4,ICAM1,IL1R1,IRF8,RHOA,TEK,VCAM1 | 715 (14) |
| reserpine | NA | chemical drug | NA | -1.03e+00 | NA | 1.0e-02 | ADRA2A,ADRB2,CNR1,EGR1,GNAI3,GNAS,NTS | 958 (13) |
| Ras homolog | NA | group | NA | -1.03e+00 | NA | 2.0e-02 | ABCA1,CCND1,CDKN1A,EGR1,IL16,ITGB3,PDGFRA,PTGS2 | NA |
| caspase | NA | group | NA | -1.03e+00 | NA | 1.0e-02 | ACER2,CCND1,CCND2,CDK2,CDK6,CDKN1A,GLUL,HERPUD1,IL2RA,NCF1,THBS1 | 1527 (25) |
| SOD2 | 6.00e-02 | enzyme | NA | -1.03e+00 | NA | 2.0e-02 | ACADL,ACP5,ATP1A1,BCL2L1,CDKN1A,COLEC12,GCH1,GLYCTK,ID2,IL7,KLKB1,MAP2,MARK1,MLXIP,MMP2,MYO3B,PLAGL1,PTGS2,PTPRO,SERPINE1,SLC19A2,SORT1,SPEG,SYP,TGFB1,TMC1 | NA |
| DPP4 | -1.39e+00 | peptidase | NA | -1.04e+00 | NA | 0.0e+00 | ACTA2,Ccl2,CD86,CDH1,CXCL10,EGR2,FAP,FGF2,IL17A,IL1RN,MMP14,MMP2,SREBF1,TGFB1,THBS1,TIMP1,TOP2A | 1197 (20) |
| SOST | NA | other | NA | -1.04e+00 | NA | 1.0e-02 | ACADS,ACP5,AXIN2,Ccl2,CD36,CTSK,LPL,NKD2,NOX4,PLIN1,PPARG,SREBF1 | 1302 (18) |
| GCG | NA | other | NA | -1.04e+00 | NA | 0.0e+00 | ACADL,ACADS,ACKR3,ADD3,ADIPOQ,BCL2L1,BMP4,BTG2,CASP3,CGNL1,CYBA,ELMO1,ELN,FN1,GCGR,GFRA1,GREM2,HK1,IGFBP4,LIMA1,LPIN1,MME,NFYA,NR4A1,NR4A2,NR4A3,PALM,PHLDB2,PLK3,PPARGC1B,PPP1R1A,PPP1R3C,RAP1GAP,SLC25A25,SLC2A1,SLC9A3,SNX3,SORT1,SREBF1,ST14,TGFB1,TNFAIP6,VCAM1 | 1855 (23) |
| 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene | NA | chemical toxicant | NA | -1.04e+00 | NA | 0.0e+00 | ABCC3,ABCC4,ACADL,BUB1,BUB1B,CCNA2,CCND1,CDK2,CDK6,CDKN1A,CKAP4,CYP27A1,CYP39A1,CYP7B1,DIO1,EIF4EBP1,FAM107B,GADD45B,ICAM1,IL1R1,LRG1,MAFF,MCM7,Mt1,NEDD9,PDE3B,PNPLA2,RARRES1,Slco1a4,SREBF1,TMPRSS2,TNFAIP2,UCP3 | 1441 (21) |
| RAG2 | NA | enzyme | NA | -1.04e+00 | NA | 1.0e-02 | ALOX15,ANKRD1,ASTE1,CCDC152,CCDC8,CXCL10,EPHA4,FCGRT,FGR,FMN1,GPR183,IL1RL1,IL2RA,IRF3,ISG15,KLF5,MAL,MET,NKD2,PEX16,PTP4A3,RAP1GAP,SMPD3,STAT1,TNFRSF10A,TNFRSF1B,VSTM4,ZNF385A | 1456 (22) |
| ABL1 | 3.10e-01 | kinase | NA | -1.04e+00 | NA | 4.0e-02 | BCL2L11,C3,CAV1,CCNA2,CCND1,CCND2,CDKN1A,CSF1,GADD45A,IER3,TEK,TP63 | NA |
| PTGES | -1.31e+00 | enzyme | NA | -1.05e+00 | NA | 0.0e+00 | ANXA1,ANXA2,Ccl2,CDH1,CDKN1A,CXCL14,CYBA,CYBB,EGR1,ERBB3,EZR,GATA4,IL17A,ITGA6,ITGAL,ITGB4,LAMP2,MYH6,MYH7,NCF1,NEB,NOP2,NOS1,NOX1,NOX4,PPARG,PTGES,PTGS2,RHOA,SERPINE1,VIM | 1471 (22) |
| LGR4 | 4.00e-01 | transmembrane receptor | NA | -1.05e+00 | NA | 0.0e+00 | AHR,AXIN2,BLVRB,CDH1,CXCL10,GLUL,KDM2B,LEF1,SFRP4,SNAI1,STAR,TWIST1,VIM,WNT4,WNT5A,ZEB2 | 1529 (22) |
| palbociclib | NA | chemical drug | NA | -1.05e+00 | NA | 0.0e+00 | ATF3,B2M,CCND1,CD83,CDK6,CDKN1A,CENPF,CXCL10,DUSP1,EGR1,EGR3,GADD45A,GADD45B,GBP4,HLA-A,ID2,IFI44,IFIT1,IRF5,IRS2,ISG15,KIF11,KLF10,MKI67,MX1,NCAPG,NR4A2,OASL,OLR1,PER1,PRKCB,S100B,SOCS3,USP18,ZFP36 | 1271 (19) |
| PTAFR | -1.54e+00 | G-protein coupled receptor | NA | -1.05e+00 | NA | 4.0e-02 | CASP1,CDH1,CDH2,MMP2,NLRP3,PTGS2,SNAI1,VIM | NA |
| NFE2L2 | -7.00e-01 | transcription regulator | NA | -1.05e+00 | NA | 0.0e+00 | ABCC3,ABCC4,ACSL5,ACTG1,ADAMTS1,ADH7,AHR,ALDOA,AOX1,APBA3,ARF1,ARHGEF3,ARID5B,ATF3,ATP1A1,BCL2L1,BDNF,CA3,CALB1,Calm1 (includes others),Ccl2,CCNE2,CD36,CD86,CDC34,CDH1,CDKN1A,CDKN2C,CNMD,COL1A1,COL3A1,COQ7,COX4I1,CTSK,CXCL10,CYBB,DAD1,DDX6,DHCR7,DYNLL1,EIF2AK3,EIF3C,EIF3G,ELN,EMCN,EPHB4,EPHX1,FABP1,FKBP5,FN1,FOXO3,FTL,G6PD,GADD45G,GAS2,GBE1,GCLC,GFAP,GPX3,GSR,Gsta4,HACD3,HAX1,HERPUD1,HSP90AA1,ICAM1,IDH1,IFIH1,IL1RN,ISG15,ITGB7,KCND1,KCNMB4,KDR,L1CAM,LAMP2,LPL,MAFF,MAP1LC3A,MAP1LC3B,MATK,MGST1,MITF,MMP14,MRPS18B,MSMO1,Mt1,MYH10,NCF1,NCF2,NFE2L2,NGEF,NR0B2,NRK,NSMF,OGT,PDIA4,PHGDH,PHKA1,PIK3R1,PIR,PITX2,Pmaip1,PPARG,PPARGC1B,PPIB,PRDX1,PRKCB,PSMA4,PSMA6,PSMB1,PSMB5,PSMC1,PSMD13,PTCH1,PTGS2,PTPRB,PTPRO,RELN,RPL18,RPS16,RSAD2,RUNX1T1,S100A13,SEC23A,SERPINE1,SLC16A2,SLC1A1,SLC1A4,SLC2A1,SLC38A1,SLC38A3,SLC3A1,SLC6A9,SLC7A8,SNAI2,SOCS3,SREBF1,SYP,TBRG1,TBXAS1,TGFB1,TKT,Tpm1,UBC,UBQLN2,UGDH,VCAM1,VCP,VEGFD,VSNL1,ZFC3H1 | 1074 (14) |
| beta-glycerophosphoric acid | NA | chemical - endogenous mammalian | NA | -1.05e+00 | NA | 3.0e-02 | CDKN1A,DMP1,PTGS2,RUNX2,SLC20A1,SPARC,SPP1,TNFRSF11B | NA |
| AR | 8.00e-02 | ligand-dependent nuclear receptor | NA | -1.06e+00 | NA | 0.0e+00 | ABCA1,ABCC4,ABCG1,ACTA1,Akap17b,Akr1b7,ALDH1A1,AMD1,AMHR2,ANKRD1,ARG1,ARMCX2,ATP2A2,BCL2L1,BCL2L11,BMP15,BMP4,BOP1,BPGM,BUB1,BUB1B,C3,CALU,CAMK2A,CASQ2,CAV1,CAV2,Ccl2,CCL24,CCNA2,CCND1,CCNI,CDC25B,CDCA7L,CDH1,CDH11,CDH2,CDK14,CDKN1A,CDO1,CERS6,CHRNA1,CIT,CKAP4,CLDN3,CNN3,COL3A1,COTL1,COX4I1,COX6B1,CSRP3,CUX1,CUX2,CXCL12,CXXC5,DAB2IP,DCTPP1,DDIT4,DEPDC1,DHCR7,DHH,DMPK,EBP,EDN1,EDNRB,EGR1,EHD3,ELMO1,EMB,ENO2,EPB41L4B,EPHX1,ERBB3,ESPL1,ESYT3,ETV1,FAM89B,FEN1,FGF10,FKBP5,FOXO1,FZD2,FZD6,GADD45G,GFAP,GOLM1,GPD1,HGF,HIF1A,HLA-A,HOPX,HS6ST2,HSPB7,ICAM1,IFIH1,IGF1,IGFBP5,IL17RE,IL1R1,INHA,INPP4B,ITGA2,ITGA6,ITGB4,KCNA1,KCNH2,KDELR2,KDM4B,KIF4A,KITLG,KLKB1,KNTC1,LMOD1,LRRK1,ME2,MICALL2,mir-133,MME,MMP2,MRAS,MRPL27,MSI1,MSMO1,MSTN,MTHFD2,MYH6,MYL3,MYOD1,MYOG,NFATC2IP,NPR3,NR5A1,NR5A2,OCLN,OXCT1,P2RX2,P3H2,PCDH11X,Pcp4l1,PCSK1N,PDCL,PDGFRA,PDIA5,PDLIM4,PENK,PER1,PIM3,PLAT,PLK1,PLOD2,PLP1,PLS3,PLTP,PMEPA1,PNMT,PPP3CA,PRKCD,PROS1,PTCH1,PTPRF,RARRES1,REC8,RGN,RHBG,RNF128,RP2,SCN4A,SCN5A,SERP1,SERPINE1,SGK1,SKP2,SLC26A7,SLC39A8,SLC41A2,SLC45A3,SLCO3A1,SMOX,SMYD1,SNAI1,SNAI2,SPP1,STAR,STARD10,STAT1,SULF2,TACC2,TBC1D8,TBXAS1,TGFB1,THBS1,TLR4,TMEM176A,TMEM176B,TMEM52,TMPRSS2,TNFAIP2,TNNT2,TP63,TPD52L1,TRIP6,TSPAN8,TWF2,TWIST1,UNC5C,VCAN,VEGFC,VIM,VSNL1,WEE1,WIPF1,WNT4,ZBTB16,ZFYVE19 | 1670 (17) |
| PELP1 | 2.80e-01 | other | NA | -1.06e+00 | NA | 0.0e+00 | ACTG2,ADRB2,AHNAK2,ASNS,AUTS2,B3GALNT1,BCL2L1,CCND1,CDC42EP5,CDK2,CDKN1A,CKMT1A/CKMT1B,COL12A1,CTSH,CXXC5,CYGB,DAB2,DOCK11,EGF,FBN2,FUCA1,FYN,G0S2,GCA,GJB2,HS3ST5,IFI44,IKBKE,KCNK2,LCP1,LOXL4,MAP1B,MAP1LC3B,MAPK4,MMP2,MRAS,MRC1,MYADM,NCOR2,P3H2,PPARG,PRKCQ,PTGES,PTGS2,SLC1A3,SRSF12,TAGLN | 1544 (26) |
| XBP1 | -2.30e-01 | transcription regulator | NA | -1.06e+00 | NA | 0.0e+00 | ADAM10,ALG2,ARFGAP3,ATP2A2,Ccl2,CREB3L1,DAD1,DNAJC1,EDEM1,EIF2AK3,ERO1B,ERP44,ETS1,FKBP10,FKBP11,FKBP7,FN1,GGCX,GOLGA4,GORASP2,HERPUD1,HLA-DRA,ICAM1,IRF4,KDELR2,KDELR3,KLF4,LMAN2,MAFA,MAN1A1,MAP1LC3B,MGAT2,NCF1,PDIA4,PDIA5,PPIB,PRDM1,RABAC1,S100A6,SEC23A,SEC24D,SELENOM,SERP1,SLC1A5,SLC38A1,SLC38A2,SPARC,SPCS3,SREBF1,SRP68,ST8SIA2,STT3A,TNFRSF10A,TRAM1,UFM1,VCAM1,WNT10B | 1083 (15) |
| topiramate | NA | chemical drug | NA | -1.06e+00 | NA | 1.0e-02 | ADH7,ARHGEF3,CASP3,CYP7B1,GADD45GIP1,IRF4,LDLRAD1,MYO1D,PTCH1,PTPRF,RET,SGO1,TGFB1,TNFSF8,TRADD,TYRO3 | NA |
| TMTC3 | -8.20e-01 | enzyme | NA | -1.06e+00 | NA | 2.0e-02 | CDH1,CDH2,EIF2AK3,VIM | NA |
| PIN1 | 4.60e-01 | enzyme | NA | -1.06e+00 | NA | 5.0e-02 | BCL2A1,BTK,BUB1,CCND1,CCNE2,CDH2,CDK5R1,CDKN1A,COL3A1,DEPDC1,EPB41L4B,FN1,MAP1LC3A,MMP2,NCOR2,PPARD,PTGS2,TGFB1,TIMP1,TNFRSF10A | NA |
| GSK2816126 | NA | chemical drug | NA | -1.06e+00 | NA | 0.0e+00 | BMP5,Ccl2,CD200,CDH2,CNMD,CTNNAL1,CXCL10,DLK1,DUOX2,FRZB,GPC3,HIVEP3,HOXD4,KCNMB4,KLF5,POLE3,RUNX2,SNAI1,SOSTDC1,SPARC,SPP1,TACC3,WNT10B | 939 (13) |
| MUC1 | NA | other | NA | -1.06e+00 | NA | 0.0e+00 | ALDH1A1,ARG1,BCL2L1,CCND1,CCND2,CD1D,CD83,CD86,CDH1,CDH11,ERO1B,GCLC,HGF,HIF1A,HLA-DRA,IFIH1,IKBKB,ISG15,MGST1,MKI67,MRC1,NFKBIA,NRP1,OASL,SNAI1,SNAI2,STAT1,VIM | 1542 (19) |
| TMSB4 | NA | group | NA | -1.06e+00 | NA | 1.0e-02 | BMP4,DMP1,ITGA1,ITGA2,ITGA3,RUNX2,SERPINE1,SPP1 | 1345 (20) |
| orantinib | NA | chemical drug | NA | -1.07e+00 | NA | 0.0e+00 | CASP3,GLI1,ICAM1,VCAM1 | 1334 (19) |
| Rar | NA | group | NA | -1.07e+00 | NA | 1.0e-02 | ADAM10,ARG1,BTG2,CDKN1A,CRYAB,CYP4F2,EGR1,GAS2,ITGB2,PAX3,SERPINF1,SFTPB | 1373 (24) |
| BCL2L12 | 6.30e-01 | other | NA | -1.07e+00 | NA | 1.0e-02 | CDKN1A,CRYAB,Pmaip1,TNFRSF10A | 1157 (10) |
| MUSK | 8.00e-01 | kinase | NA | -1.07e+00 | bias | 1.0e-02 | CHRNA1,CHRND,ERBB3,MUSK | NA |
| TBX1 | -4.20e-01 | transcription regulator | NA | -1.07e+00 | NA | 2.0e-02 | BMP4,CDKN1A,FGF10,LEF1,PITX2 | NA |
| 8-(4-sulfophenyl)theophylline | NA | chemical reagent | NA | -1.07e+00 | NA | 3.0e-02 | MMP2,TGFB1,THBS1,TIMP1 | NA |
| CP-55940 | NA | chemical reagent | NA | -1.07e+00 | NA | 4.0e-02 | BCL2L1,BCL9,BTG2,CSF1,GADD45A,GAPDH,GRK5,HTR2A,NFKBIA,PRKCB,UBC | NA |
| UTS2R | NA | G-protein coupled receptor | NA | -1.07e+00 | bias | 5.0e-02 | ABCA1,MSR1,PPARD,PPARG | NA |
| STAT6 | -7.20e-01 | transcription regulator | NA | -1.07e+00 | NA | 0.0e+00 | ABLIM1,ACP5,ACSL1,ADAM11,ADAM19,ALOX15,ANKRD55,ANO1,ANXA1,ARG1,ARID5A,AUH,BCL2L1,BCL3,BCL6,CAMK1D,Ccdc50,CCDC86,Ccl2,CCL24,Ccl6,CCND2,CCR5,CDK2,CDKN1A,CISH,CKAP4,COBLL1,COL1A1,COL3A1,CST7,CTSE,CTSS,CXCL10,CYBB,CYTH1,DDAH1,DDHD1,DHX58,DOCK10,DUOX2,EGR1,EGR2,EPHX1,EVC,EXT1,FABP1,FADS1,FCER1G,FCGR1A,FCGR3A/FCGR3B,FKBP5,FLRT2,FN1,FOXP3,FSCN1,GADD45B,GADD45G,GATM,GBP2,GBP5,GBP7,GCSAM,GNB4,H2-T22,HBA1/HBA2,HCK,HLX,HRH1,IFI16,IFI44,IFI44L,IFIH1,IFITM3,IGF1,IL10RA,IL17A,IL18R1,IL1RN,IL2RA,IL33,IL4I1,IRAK3,IRF1,IRF4,IRS2,ISG15,ITGB7,ITPK1,JAG1,LACTB,LCP2,LDLRAD3,LY75,MAF,MMP14,MMP2,MMP28,MOV10,MRC1,MVK,NEDD9,NFIL3,NFKBIA,OAS3,OASL,PARM1,PDGFC,PDK4,PKIB,PLD1,PNPLA2,POU2F2,PREX1,PROS1,PSTPIP1,PTGS2,Ptprv,RAB30,RASSF4,RHOA,RIPK3,RNF213,RNPEP,S100A10,SAMSN1,Scd2,SELE,SELENBP1,SELP,SERPINE1,SERPINF1,SLC25A25,SOCS1,SPDEF,SPHK1,ST6GAL1,STAT5B,STAT6,SYK,Tcf7,TES,TGFB1,THY1,TIMP1,TLE1,TMEM176B,TNFRSF8,TNIP2,TRPV2,VCAM1,VIM,ZFP36,Zfp53,ZNF608 | 1587 (17) |
| KLKB1 | -1.53e+00 | peptidase | NA | -1.07e+00 | NA | 0.0e+00 | BDKRB2,F3,ICAM1,KLF4,VCAM1 | 1234 (15) |
| CaMKII | NA | complex | NA | -1.07e+00 | NA | 2.0e-02 | ARG1,BDNF,BIRC3,CD44,COL2A1,HAS2,IRF1,PRKCZ | NA |
| VDR | -5.30e-01 | transcription regulator | NA | -1.07e+00 | NA | 0.0e+00 | ABCC3,ACTA2,ADIPOQ,ANGPT2,ARHGEF3,BCL2L1,BUB1B,CALB1,Ccl2,CCND1,CCND2,CD36,CD44,CDH1,CDKN1A,CISH,CLDN1,COL1A1,CSF1,CXCL10,DCTPP1,EDN1,EGR1,EZH2,F3,FEN1,GADD45A,GADD45G,GLI1,GPD1,GPX3,Hmgn2 (includes others),ICAM1,IER3,IFI44L,IGFBP5,IL17A,IL1RN,IQGAP1,ISG15,ITGB7,KIF11,LBH,LGALS1,LPL,MAGI1,MYF5,MYH3,MYH8,MYOG,NDUFV2,NEDD9,NOD2,NR0B2,OCLN,PLD1,PNPLA2,PPARG,PPARGC1B,PRC1,PTGS2,PTPRF,RGCC,RNF144A,RUNX2,SELE,SOCS1,SOCS3,SPP1,SREBF1,THBD,TLR2,TMPRSS2,TP63,TPH1,UCP3,WSB1 | 1070 (18) |
| genistein | NA | chemical drug | NA | -1.07e+00 | NA | 0.0e+00 | A2M,ABCA9,ABCB9,ACP5,ALOX5,AP1B1,AP1S2,ARG1,ARSG,ATP6V0A4,ATP6V0B,ATP6V1A,BCL2L1,BCL3,BDNF,BTG3,C3,CASP3,Ccl2,CCND1,CD44,CD74,CD86,CDKN1A,CHPF,CHST7,CITED2,CLCN7,COL1A1,CTSH,CTSK,CX3CL1,CX3CR1,CXCL10,CXCL12,CYP4F2,DIO1,DNASE1L3,DUSP1,EVI2A,EXT1,F3,FCGR2B,FCMR,FOXP3,FUCA1,GADD45A,GCLC,GJB2,GLI1,GM2A,HIF1A,HLA-A,HLA-DQA1,HSPA1A/HSPA1B,HYAL3,ICAM1,ID2,IGF1,IKBKB,ITGB2,JUND,LAPTM4B,LBP,LCP2,LPL,LY86,MAL2,MAP4K1,MCOLN1,MMP2,MMRN1,Mt1,MTMR1,NEU1,NFE2L2,NOX1,OSBPL3,PCDH17,PER1,PFKFB4,PIK3R1,PKIB,PLA2G7,PLAT,PLK1,PLK3,PLTP,PPARG,PTAFR,PTGS2,PTPN6,RASAL3,RASGRP1,Rnase2 (includes others),RUNX2,RXRA,SERPINE1,SIGLEC10,SLC1A5,SLC36A1,SLC4A4,SLFN12,SOCS1,SORT1,SPHK1,SPP1,STAR,TAGLN,TGFB1,TICAM2,TNFRSF11B,VCAM1,WEE1,WNT5A,XYLT1,ZEB2,ZNF212 | 1407 (15) |
| Calcineurin protein(s) | NA | complex | NA | -1.08e+00 | NA | 0.0e+00 | ABRA,ATP2A2,BCL2L11,BDNF,CAMK2D,CKM,CYGB,DUSP1,EGR1,EGR2,KCNQ2,MB,MYH7,MYOG,NFATC4,NFIL3,NR4A1,NR4A2,NR4A3,PTGS2,PVALB,Rcan1,RGS2,RNF128,RYR1,SERPINE1,SPP1,TRPC6 | 960 (20) |
| calpain | NA | complex | NA | -1.08e+00 | NA | 1.0e-02 | AQP4,CCND1,CDK2,IL17A,IL2RA,NFKBIA,NTRK2,STAT6,TLR4 | NA |
| TNFRSF11A | -6.90e-01 | transmembrane receptor | NA | -1.08e+00 | NA | 2.0e-02 | BCL2L1,CXCL13,FN1,MME,RSPO1,SNAI1,TFAP2B,VCAM1 | NA |
| Relaxin | NA | group | NA | -1.08e+00 | NA | 4.0e-02 | CD36,EDN1,GATA4,HAS2,HCN4,MMP2,NOS1,TIMP1 | NA |
| quisinostat | NA | chemical drug | NA | -1.08e+00 | NA | 0.0e+00 | BCL2L1,BCL2L11,CDH1,CDH2,TP63,VIM | 780 (7) |
| TO-901317 | NA | chemical reagent | NA | -1.09e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACSL1,ACSL5,ADAM11,ADH1C,Akr1b7,APOD,BCL2L1,C3,CASP1,Casp12,Ccl2,CCL24,CCND1,CDK2,CFH,Cox8b,CRP,CYP7B1,DHCR7,DIO1,DNASE1L3,ELOVL1,ELOVL5,EPHX1,FADS1,FADS2,G6PD,GAMT,GBE1,GPAM,GPD1,GPI,Gsta4,HMGN1,HSD17B12,HSD17B8,IGF1,IGFBP4,ITGA6,LIPG,LPL,Mt1,Naip1 (includes others),NFKBIA,NR0B2,NR5A2,PFKFB3,PLTP,PNPLA3,PPARG,PRKAB1,PTGER3,PTGS2,RARA,Scd2,SKP2,SLC37A4,SREBF1,STAR,SYP,TGFB1,TIMP1,TKT,TLR4,TSHR | 1226 (21) |
| chloroquine | NA | chemical drug | NA | -1.09e+00 | NA | 0.0e+00 | ADAMTS5,ALDH1A1,ATP1A1,BCL2L1,BCL2L11,CASP3,CD36,CD83,CD86,CDH1,CDH2,COL1A1,CXCL10,DRAM1,FN1,FOXO1,FOXO3,GATA4,HIF1A,IFIH1,IRS1,LEPR,MAP1LC3B,MET,PKD2,RUNX2,SELE,SNAI1,SNCA,SOCS1,SOCS3 | 1586 (17) |
| ALDOA | 9.10e-01 | enzyme | NA | -1.09e+00 | bias | 0.0e+00 | ALDOA,HIF1A,SNAI1,SNAI2 | NA |
| trovafloxacin | NA | chemical drug | NA | -1.09e+00 | NA | 0.0e+00 | ADRB2,B2M,BHLHE40,BIRC3,CDKN1A,ERRFI1,GCLC,GNPNAT1,HLA-A,ICAM1,IL17RA,IRF1,NEDD4L,NFKBIA,PHLDA1,RDX,SELE,SERPINE1,SOCS3,SUMO2,THBS1 | 1101 (10) |
| ATF7 | 2.20e-01 | transcription regulator | NA | -1.09e+00 | NA | 0.0e+00 | DUSP1,DUSP10,DUSP5,MAPK14,SELE | 321 (5) |
| phencyclidine | NA | chemical drug | NA | -1.09e+00 | NA | 1.0e-02 | BCL2L1,CDON,CREM,HDC,IER3,PVALB,RGS4,SYP | 1002 (18) |
| SIX5 | -1.51e+00 | transcription regulator | NA | -1.09e+00 | NA | 0.0e+00 | ATP1A1,DMPK,EBF2,IGFBP5,MYOG,PLTP,PTN,SFRP2,SIM1,SIX2,SIX4,SLC6A13,ST14,TWIST2,WNT4 | NA |
| LEF1 | -1.62e+00 | transcription regulator | NA | -1.10e+00 | NA | 0.0e+00 | ACTA2,ADIPOQ,ANXA1,ARHGDIB,AXIN2,CACNA1G,CARD11,CASP3,CAV1,Ccl6,CCND1,CD101,CD1D,CD200,CD44,CD83,CDH1,CDKN1A,CEBPD,COL11A1,CSF3R,CX3CR1,CXCR4,DEPDC1B,DNASE1L3,ECM1,EMILIN2,ENO2,EPHX1,FGF10,FGFR1,FN1,G0S2,GCNT2,Gprasp2,GSAP,HAS2,HLA-DQA1,ID2,IFITM3,IL18R1,INPP5F,IRAK3,JAG1,KIF11,LAMA3,LEF1,LONRF1,METRNL,MITF,MMP2,Naip1 (includes others),NCAM1,NCF1,NCOA7,NLRP3,NOD2,NOTCH2,NR2F2,NRCAM,NTN4,NUMBL,P2RY1,PCSK1N,PDGFB,PENK,PHLDA1,PKIB,PLA2G7,PLTP,Pmaip1,PRDM1,PRDX4,PTCH1,PTGS2,PTPRO,PYGL,RASGEF1B,RFNG,RNF8,RUNX2,S100A4,SGK1,SH3BGRL2,SLC35D1,SLC41A2,SMPD3,SPECC1,SPP1,ST14,STX11,SYTL2,TGFB1,TLR2,TLR7,TMEM176A,TRPM1,VIM,WDFY4,ZC3H12D | 1613 (24) |
| histamine | NA | chemical - endogenous mammalian | NA | -1.10e+00 | NA | 5.0e-02 | BCL2L1,Ccl2,CD86,CLDN1,CXCL10,CXCR4,F3,HIF1A,HRH1,ICAM1,IL16,ITGA4,NR4A1,OCLN,PENK,PTGES,PTGIS,PTGS2,SELE,SELP,SEMA3A | NA |
| CLEC4A | -1.63e+00 | transmembrane receptor | NA | -1.10e+00 | NA | 0.0e+00 | ABCA1,ABCA9,ABCG1,ADGRE1,ALOX5,APOBEC1,BHLHE40,CAMK2A,Cd209f,CD36,CD83,CLEC4M,FCGR1A,FCGRT,FOLR2,ID2,IL17A,IRF4,MRC1,MSR1,Naip1 (includes others),RXRA,SLCO2B1,TLR2,VCAN | 1062 (10) |
| PIK3C3 | 3.20e-01 | kinase | NA | -1.10e+00 | NA | 1.0e-02 | ACADL,ADIPOQ,HLA-A,NRG4,PLIN1,PNPLA2,PPARG,PRDM16,RETN,SREBF1,VPS36 | 1060 (11) |
| AKT2 | 5.30e-01 | kinase | NA | -1.10e+00 | NA | 0.0e+00 | ACTA2,BCL2L11,BUB1,Ccl2,CDH1,CDKN1A,FOXO1,FOXP3,GCLC,GSR,IRAK3,MTSS1,MYCN,MYOG,PALLD,PPARG,SEMA6D,SOX10,TGFB1,TIMP1,VIM | 1533 (22) |
| ELOVL2 | -8.20e-01 | enzyme | NA | -1.10e+00 | NA | 2.0e-02 | BDNF,CASP1,CDH1,EGR1,SREBF1 | NA |
| RAD51AP1 | 9.00e-02 | other | NA | -1.10e+00 | NA | 2.0e-02 | CD44,CDH1,ITGA6,KLF4 | NA |
| raltitrexed | NA | chemical drug | NA | -1.10e+00 | bias | 5.0e-02 | ANXA2,CDKN1A,TMSB10/TMSB4X,TYMS | NA |
| PPID | -3.70e-01 | enzyme | NA | -1.11e+00 | NA | 0.0e+00 | CDH1,SNAI1,SNAI2,TWIST1,VIM | 1148 (7) |
| PEA15 | -9.90e-01 | transporter | NA | -1.11e+00 | NA | 2.0e-02 | EGR2,PEA15,PLD1,PLD2,PRKCZ | NA |
| ferric ammonium citrate | NA | chemical drug | NA | -1.11e+00 | NA | 4.0e-02 | C3,ELN,FTL,GADD45A,NFYA,NR4A3 | NA |
| FYN | -1.09e+00 | kinase | NA | -1.11e+00 | NA | 5.0e-02 | Ccl2,CXCL10,DAB1,DUSP1,EGR2,FOXP3,IL17A,IRF4,NLRP3,PENK,PLP1,PTGS2,SOCS3 | NA |
| SREBF2 | -3.70e-01 | transcription regulator | NA | -1.11e+00 | NA | 0.0e+00 | AACS,ABCA1,ACR,ACSL1,BMP4,CAMK1D,CDKN1A,CYP4F2,CYP7B1,DHCR7,EBP,FADS2,G6PD,GLI1,GLI2,ICAM1,IDH1,IRS2,LSS,MSMO1,MVD,MVK,NLRP3,PPARG,PTCH1,SREBF1,STAR,TIFA,VCAM1 | 1615 (24) |
| ibrutinib | NA | chemical drug | NA | -1.11e+00 | NA | 0.0e+00 | ALDOA,ASNS,ATP6V1E1,ATP6V1F,BCL2L1,BYSL,CCDC71L,CD44,CD86,CDK6,CKAP4,COX6B1,DCTPP1,DOCK5,EXOSC5,GAPDH,GPI,HK1,HSPE1,IFITM3,IMP4,ITGA4,LPAR6,MAP3K6,NDUFV1,NECTIN1,NOP16,NOP2,PES1,PLCG2,PLK1,PLK4,POU2F2,PTCH1,RCBTB2,RIPK2,RRP9,SLC1A5,SLC2A5,SLC38A1,SORD,TTC28,UGCG,UGGT2 | 1263 (21) |
| gemcitabine | NA | chemical drug | NA | -1.11e+00 | NA | 0.0e+00 | BCL2L1,BTG2,Ccl2,CCND1,CD44,CD47,CDH1,CDH2,CDKN1A,CXCL12,CXCR4,EGF,EGR1,ETS1,HIF1A,HLA-DRA,MDK,MMP2,PEBP1,PKM,PRKDC,PTGS2,RIPK3,SRSF1,TGFA,VIM | 1411 (21) |
| DRD2 | NA | G-protein coupled receptor | NA | -1.11e+00 | NA | 1.0e-02 | ATP6V1E1,BDNF,CD48,CRYAB,CSF1,CSF1R,CXCL13,EDNRB,GAD1,IGF1,IKBKB,LTBP1,MMP2,NAT8L,NFKBIA,PENK,PMEPA1,PNPLA2,PVALB,SERPINE1,TGFB1,THBS1,TUBB6,VCAM1 | 1339 (19) |
| MAPKAPK2 | 4.50e-01 | kinase | NA | -1.12e+00 | NA | 0.0e+00 | ARG1,Ccl2,Ccl7,CEBPD,CITED2,CXCL10,HDC,HSPB6,ICAM1,IRF3,MMP2,MRC1,MSR1,NFKBIA,NFKBIB,PLA1A,PLAT,RILPL1,SLA,TOP2A,VCAM1,ZC3H12C,ZFP36 | 1180 (14) |
| NR1H4 | -9.00e-02 | ligand-dependent nuclear receptor | NA | -1.12e+00 | NA | 0.0e+00 | ABCA9,ABCC3,ABCC4,ABCG1,ABHD5,ACTA2,ADGRE1,ADRB2,Akr1b7,ANKRD1,ANPEP,ATP8B1,BGN,C3,Ccl2,COL14A1,COL1A1,COL3A1,COL5A2,COL6A5,CTSC,DDAH1,EDN1,ENPEP,FABP1,FADD,FBLN5,FN1,Gsta4,IL17A,IL7,KLF4,LAMA4,LCAT,MAFA,MMP2,NFAT5,NR0B2,NR5A2,PGM1,PLTP,PNMT,PNPLA3,PPARG,PPARGC1B,PTGS2,RARA,RXRA,SDC1,SEMA7A,SPP1,SREBF1,TCEA2,TGFB1,TGFBI,THBD,TIMP1,TNFRSF10A,TNFSF8,UCP3 | 1262 (21) |
| THY1 | -1.29e+00 | other | NA | -1.13e+00 | NA | 1.0e-02 | AXL,CDH1,ETS1,MMP2,PDGFB,TGFB1,VIM | NA |
| folic acid | NA | chemical - endogenous mammalian | NA | -1.13e+00 | NA | 0.0e+00 | ACTA2,BCL2L1,Ccl2,CDH1,CDKN1A,CERS6,COL18A1,COL1A1,COL3A1,CYBB,ESRRG,FABP1,FN1,FZD1,FZD6,HDAC4,HDAC7,HGF,LGALS1,LGALS9B,MMP2,MSI1,NLRP3,NOX4,PITX2,PYCARD,SFRP1,TEK,TGFB1,TYMS,VCAM1,WNT4,WNT6 | 1442 (21) |
| laduviglusib | NA | chemical drug | NA | -1.13e+00 | NA | 1.0e-02 | AXIN2,CASP3,ESRRB,GPNMB,IL33,KIT,KLF4,NDUFB9,PPARG,SNAI1,SPP1,SREBF1,TBX3,TFCP2L1 | NA |
| WNT4 | 8.90e-01 | cytokine | NA | -1.13e+00 | NA | 0.0e+00 | ACTA2,AXIN2,CCND1,CDH1,CDH2,COL1A1,CTHRC1,DLK1,FKBP5,FOXO1,IL34,MYF5,MYOD1,NR2F1,OCLN,PDGFD,PTGS2,RUNX2,SPARC,SPP1,STAR,TGFB1,VWF,WNT6 | 1489 (22) |
| AGER | 2.00e-02 | transmembrane receptor | NA | -1.13e+00 | NA | 0.0e+00 | ARG1,BCAN,CALCR,Ccl2,CCND1,CDKN1A,CKM,CSF1,CTSK,EGR1,F3,FN1,ICAM1,IFI16,IFIT1,IGF1,LPL,MMP2,MYOG,NEFL,PDGFB,PTGS2,RNF5,SELE,SELENBP1,SERPINE1,TGFB1,TLR4,TNC,VCAM1,WNT10B | 1298 (15) |
| GALNS | 5.20e-01 | enzyme | NA | -1.13e+00 | NA | 0.0e+00 | BDNF,GAP43,GFAP,MAP2 | NA |
| NDST2 | 2.20e-01 | enzyme | NA | -1.13e+00 | NA | 0.0e+00 | CMA1,CPA3,FN1,Mcpt4 | NA |
| CD 437 | NA | chemical drug | NA | -1.13e+00 | NA | 0.0e+00 | ALDOA,ARF1,ARHGDIB,BANF1,CDKN1A,CLIC1,CNR1,CST7,DNAJA1,EIF3G,F3,FKBP5,FLT3LG,FSCN1,FTL,GADD45A,GNAS,HIC1,HNRNPC,HSP90AA1,IMP3,ITGA11,LGALS1,LSM3,MGST1,MOB1A,NDUFB9,NFKBIA,NR0B2,NR4A1,PFN1,PSMA4,PSMB1,RASL10B,RPS10,RPS15,RPS16,RPS2,SLC25A6,SLIRP,SP140,SRSF3,SSBP1,STOML2,TMEM14C,TMSB10/TMSB4X,TNFRSF10A,TOMM7,TUBA1A,UBE2M,UBL5,UGCG | 614 (7) |
| ASPSCR1-TFE3 | NA | fusion gene/product | NA | -1.13e+00 | bias | 0.0e+00 | ATP6V1E1,AVPI1,BHLHE40,BIN1,CELF2,CRYAB,EZR,G0S2,GABARAPL1,GPNMB,KLHL21,MAFF,MET,MYOF,OLFML2A,PMP22,POPDC2,RAB32,RAB7A,RALGDS,SLC19A2,SLC9A1,STX3,SV2B,TACC2,THEMIS2,UAP1L1,VAT1 | NA |
| pyridoxine | NA | chemical - endogenous mammalian | NA | -1.13e+00 | NA | 1.0e-02 | FZD1,FZD6,PITX2,PTGS2,SFRP1,WNT4,WNT6 | NA |
| hexarelin | NA | chemical toxicant | NA | -1.13e+00 | NA | 1.0e-02 | IGF1,LPL,PNPLA2,PPARG,SLC27A1,SREBF1,TIMP1 | NA |
| 4-hydroxytamoxifen | NA | chemical drug | NA | -1.14e+00 | NA | 0.0e+00 | ACTC1,ATF3,BCL2L1,BCL2L11,BHLHE40,C3,CCND1,CDH1,CDKN1A,CEBPD,COL16A1,CYP1B1,DDIT4,DUSP1,DUSP5,DYNLL1,EDN1,EGR1,ERRFI1,FADD,FGFR1,FOXO1,GLRX,GM2A,HEBP1,IER3,IGF1,KRT19,MAPK14,MKI67,NCOR2,NEDD9,NFKBIA,NR4A2,OGT,PDK4,RARA,RND1,SERPINB9,SGK1,SLC10A3,SLC2A1,SLC39A8,SNAI2,SPHK1,TGFA,TM4SF1,TMOD1,ZFP36 | 1591 (19) |
| haloperidol | NA | chemical drug | NA | -1.14e+00 | NA | 0.0e+00 | ADORA2A,BDNF,CACNA1D,DPP6,EGR1,FGF2,GFAP,GSK3A,HOMER1,Klf16,LOC100359583/Ptma,NR4A1,NR4A2,NR4A3,NTRK2,NTS,Pcsk1,PENK,PER1,PRKAR2B,PRKCE,PVALB,RASGRF1,SCN1B,SCN2B,Slco1a4,WNT5A | 1123 (18) |
| MSX1 | -4.70e-01 | transcription regulator | NA | -1.14e+00 | NA | 0.0e+00 | BMP4,CDKN1A,COL2A1,EGR2,EPHA4,MYF6,MYOD1,MYOG,RUNX2,SFRP1 | NA |
| PTPRB | 7.90e-01 | phosphatase | NA | -1.14e+00 | bias | 0.0e+00 | ANGPT2,EDN1,EMCN,FOXO1,PDGFB | 1298 (11) |
| FZD7 | 1.90e-01 | G-protein coupled receptor | NA | -1.15e+00 | NA | 0.0e+00 | CCND1,CD44,CDH1,GCLC,GSR,JAG1,SNAI2,TP63 | 1151 (9) |
| trans-aminocyclopentane-1,3-dicarboxylic acid | NA | chemical reagent | NA | -1.15e+00 | NA | 0.0e+00 | BDNF,MAG,PLP1,PRKCZ | NA |
| sesame oil | NA | chemical reagent | NA | -1.17e+00 | NA | 2.0e-02 | EGR1,PPARD,PTGS2,PTN,TIMP1 | NA |
| 2,3,4,7,8-pentachlorodibenzofuran | NA | chemical toxicant | NA | -1.17e+00 | NA | 0.0e+00 | CA3,CACNA1D,CD44,COL1A1,Cox8b,CYP1B1,DACT2,EGF,EPB41L3,FGF9,FOXO1,GADD45A,GRHPR,HSPA1A/HSPA1B,HSPA2,IDH1,NR0B2,NR2F1,PRKAR2B,PTGFR,TMSB10/TMSB4X | 772 (7) |
| WT1 | -4.20e-01 | transcription regulator | NA | -1.17e+00 | NA | 0.0e+00 | ADGRE5,AMHR2,ANPEP,ASNS,BCL2A1,BCL2L1,BTG2,BTK,CCL21,CCL24,CCND1,CDH1,CDKN1A,CDKN2C,CKM,CLIC1,CLIC4,CMPK1,CREBZF,CSF1,CSF1R,CSPG4,CX3CL1,CXCL10,EGR1,ENO2,ETS1,EZR,FGF1,FGFR1,GPKOW,GSR,HCFC1R1,HNRNPL,IFRD2,IGF1,IL1RN,IL2RB,INHA,IRF8,JUND,KLF4,LSS,MGST1,MMP14,MMP2,MSLN,MYCN,NR4A2,NR5A1,NRAP,NTRK2,NUCB1,PDE8A,PDIA4,PHLDA1,PIR,Podxl,PPIB,RARA,ROCK1,Scd2,SDC1,SEC13,SERPINE1,SLC20A1,SLC2A1,SNAI2,ST6GAL1,TCOF1,TGFB1,THBS1,TM4SF1,TNFSF8,WDR90,WNT4,ZDHHC9 | 1598 (23) |
| 22(S)-hydroxycholesterol | NA | chemical - endogenous mammalian | NA | -1.17e+00 | NA | 2.0e-02 | ABCA1,ABCG1,GLI1,LPL,PTCH1 | NA |
| FADD | -6.80e-01 | other | NA | -1.18e+00 | NA | 0.0e+00 | ARID5A,ASB13,BIRC3,CASP3,Ccl2,CCND2,CD34,CDK2,CDK6,CDKN1A,CXCL10,CXCR4,DHX58,EGR1,FADD,GADD45B,ICAM1,IFIH1,IRF5,KLF6,MYF5,MYOG,NFIL3,RNPC3,SOCS1,Sp100,ST8SIA4,STAT1,TIAM2,TIPARP | 884 (16) |
| PDGFRA | -6.40e-01 | kinase | NA | -1.18e+00 | NA | 0.0e+00 | ACTA2,CDKN1A,COL1A1,DAB2,EZH2,KIT,PDGFRA,PRKCQ,RUNX2 | 1488 (20) |
| RUNX2 | -1.92e+00 | transcription regulator | NA | -1.18e+00 | NA | 0.0e+00 | ACTA2,ADAMTS5,AXIN2,CCND1,CCR5,CDH1,CDH2,CDKN1A,CEBPD,CIITA,COL11A1,COL1A1,CSNK2B,DPYSL3,EDN1,FLRT2,FN1,GADD45B,GDF10,GNAS,HIF1A,ITGAL,ITGB4,ITGBL1,JAG1,LEF1,LUM,MKI67,MMP14,MMP2,MYOD1,NUDT12,PCDH18,RGCC,RUNX1,RUNX2,SERPINE1,SGPP1,SMAD6,SNAI1,SNAI2,SOX6,SPP1,TAGLN,TIMP1,TNFRSF11B,UGCG,WNT10B | 1222 (16) |
| MAP3K7 | -1.40e-01 | kinase | NA | -1.18e+00 | NA | 0.0e+00 | ACTA1,BIRC3,Ccl2,Ccl7,CFB,CXCL10,GATA4,GBP2,GCH1,IFI44,IFIH1,IFIT1,IRF1,MYF5,MYH7,MYOD1,MYOG,OASL,PDGFB,PTGS2,RGS2,SELE,SERPINE1,WNT5A | 1430 (18) |
| CXCR4 | -8.30e-01 | G-protein coupled receptor | NA | -1.19e+00 | NA | 0.0e+00 | ACKR3,AXL,CCND1,CD44,CD9,CDH1,CDH11,CDH2,CDKN1A,CXCL10,CXCL12,CXCR4,DPP4,EGR1,F3,GAD1,ID2,IGFBP7,IL2RA,MMP2,PGK1,Podxl,RUNX2,TNFRSF10A,TNNC1,ZBTB16 | 1336 (18) |
| STAT2 | 2.90e-01 | transcription regulator | NA | -1.19e+00 | NA | 0.0e+00 | CAV1,Ccl2,CD86,CIITA,CXCL10,GHDC,GLI1,Ifi47,IFIT1,IRF1,IRF5,ISG15,MX1,NOX1,Oasl2,PITX2,RSAD2,RTP4,SOCS1,SOCS3,STAT1,USP18 | 1147 (17) |
| LINC01133 | NA | other | NA | -1.19e+00 | NA | 1.0e-02 | AXIN2,CCND1,CDK2,CDK6 | NA |
| CYB561A3 | -9.00e-02 | enzyme | NA | -1.20e+00 | NA | 2.0e-02 | ABCA1,ACTG2,AP1B1,COTL1,DUSP5,FTL,HSPA1A/HSPA1B | NA |
| E2F4 | 3.80e-01 | transcription regulator | NA | -1.20e+00 | NA | 3.0e-02 | ATRX,BARD1,BCL2L11,CCNA2,CCND1,CCNE2,CDCA4,CDK2,CDKN1A,CDKN2C,CSDE1,CSTF1,DUOX2,E2F2,E2F8,ECT2,EFHC1,FEN1,H2AC18/H2AC19,HLTF,IER5,KHDRBS1,KIF4A,KLF5,LPAR1,MKI67,MYCN,PCSK1N,PGRMC1,PLK1,POLA1,POLA2,PPARG,PPP1R13B,PPP2R2B,PRC1,PRKDC,RABIF,RANBP1,RBBP4,RBL1,RFC2,SERPINE1,SFRP1,SMC2,STMN1,TOP2A,TP53BP2,UHRF1,UMPS | NA |
| MAPK7 | -8.00e-02 | kinase | NA | -1.20e+00 | NA | 0.0e+00 | AACS,ADAMTS1,ADRB2,BCL2A1,BDNF,CCND1,CDH2,CXCL10,DHCR7,DLC1,DUSP1,EDN1,KLF4,LSS,MSMO1,MVD,MVK,NR4A1,PLAT,PTGS2,SEMA3F,SREBF1,TEK,THBD,TP63,VIM | 1451 (24) |
| SERPINH1 | -1.19e+00 | other | NA | -1.20e+00 | NA | 0.0e+00 | CDH1,CDH2,COL1A1,DDR2,SERPINE1,SNAI1,VIM | 1159 (19) |
| CL 316243 | NA | chemical drug | NA | -1.20e+00 | NA | 1.0e-02 | ACADL,ADGRE1,ATF3,Ccl2,CD36,COX4I1,Cox8b,EBF2,PDK4,PRDM16,PTGS2,SLC2A1,UCP3 | NA |
| ITGA4 | 8.70e-01 | transmembrane receptor | NA | -1.21e+00 | NA | 2.0e-02 | IL1RN,ITGA4,ITGA5,MMP2,RAC2 | NA |
| bee venom | NA | chemical - endogenous non-mammalian | NA | -1.21e+00 | NA | 0.0e+00 | Ccl2,Ccl7,CDC42EP4,CNNM2,CREM,CYBB,CYTIP,DDX27,DDX6,DNAJB1,GADD45A,ICAM1,IL4I1,IRF1,ITGA5,KIF23,KLF4,LCP2,MKI67,MSN,NFIL3,NFKBIA,NLRP3,NR4A2,OASL,PRC1,PTGS2,RGS2,Slfn2,SNTB2,SOCS3,THBD,TNFAIP2,TOP2A | 1018 (11) |
| EDN3 | -2.18e+00 | other | NA | -1.21e+00 | NA | 2.0e-02 | CCND1,CDH1,CDH2,EGR1,FGF2,ITGA2,ITGA5,ITGB3 | NA |
| adenosine | NA | chemical - endogenous mammalian | NA | -1.21e+00 | NA | 0.0e+00 | BCL2L1,CD28,CD86,CX3CR1,CXCR4,DPP4,GAPDH,GNAS,HIF1A,ICAM1,IL1R1,IL2RA,ITGB2,NR4A2,PLAT,PTGS2,SERPINE1,SOCS3,SREBF1,TIMP1,TLR4 | 1029 (16) |
| IKBKE | -1.13e+00 | kinase | NA | -1.21e+00 | NA | 0.0e+00 | BIRC3,Ccl2,CCND1,CXCL10,CXCL12,ENO3,GLI1,HLA-A,IDH3A,IFI16,IFIH1,IFIT1,IKBKE,IL17A,IL7,MAT2A,NFKBIA,PDK4,PGK1,PGM1,PHGDH,PTCH1,PTGS2,PYGL,RSAD2,SLC16A1,SLC16A3,SLC2A1,STAT1,ZC3HAV1 | 828 (18) |
| MEF2C | 1.70e-01 | transcription regulator | NA | -1.22e+00 | NA | 0.0e+00 | ABRA,ACTA1,ACTC1,ACTN2,ASPA,ATF3,ATP2A1,ATP2A2,BCAS1,BDNF,CASQ2,CCBE1,Ccl2,Ccl6,CCR5,CDKN1A,CKM,COL11A1,COL1A1,COL2A1,COL3A1,Cox8b,CXCR4,ECM2,EGR2,FAP,FRZB,GATA4,GFAP,GJA5,HDAC9,HSPB7,IRF4,JUND,KCNA5,MAG,mir-133,MYH6,MYH7,MYL2,MYOD1,MYOG,MYOM2,MYOZ1,NR4A1,PHKA1,PLA2G2A,PLAGL1,PLP1,PTGES,PTGS2,PTPRB,RUNX2,S100A4,SCN5A,SFRP2,SMYD1,STAR,SYK,THBS1,TNNC1,TNNI1,TNNI2,TNNT1,TNNT2,TSPAN2,VIM,ZFP36 | 1245 (20) |
| GDF11 | -1.25e+00 | growth factor | NA | -1.22e+00 | NA | 0.0e+00 | ACVR1,ATP2A2,BAMBI,BMP4,CCND2,COL1A1,COL2A1,CSF1,CTSK,ICAM1,ITGA2,ITGA3,ITGA5,LAMA3,MSTN,PDGFB,PRKAA2,PTGS2,RUNX2,SGK1,SMAD6,SMAD7,SMAD9,SPP1,TGFB1,THBS1,VCAM1 | 950 (14) |
| ERN1 | 2.00e-02 | kinase | NA | -1.22e+00 | NA | 0.0e+00 | ACTA2,ATF3,ATP2A2,BLOC1S1,Ccl2,CDH1,CDH6,CEBPD,CYP1B1,EDEM1,ERO1B,ERP44,ETS1,FKBP11,FN1,GP1BB,HOOK1,IKBKB,LAD1,LGR5,LPCAT2,MAP1LC3B,MPZL2,MVD,MYH7,NOX4,PDIA5,PDRG1,PPARG,PRKDC,PROS1,SEC24D,SLC20A1,SLC25A28,SLC7A1,SPARC,SPTLC3,SRP68,ST14,TINAGL1,TMED3,TMPRSS2,TSPAN2 | 943 (16) |
| indican | NA | chemical - endogenous mammalian | NA | -1.22e+00 | NA | 0.0e+00 | ACTA2,ANGPT2,ATP6AP2,CA9,CDH1,CDKN1A,CITED2,CXCR4,ICAM1,NFE2L2,NOX4,PTGS2,SELE,SELP,SLC2A1,TGFB1,THBS1 | 1093 (16) |
| SP3 | -5.50e-01 | transcription regulator | NA | -1.22e+00 | NA | 0.0e+00 | ABCA1,ACSL1,ACTA2,ADCY4,ADD3,AHRR,AKAP12,ALOX12,ANGPT2,APBA1,ASNS,ATF3,Ccl2,CCND1,CDC25B,CDH2,CDK5R1,CDKN1A,CDKN2C,CEACAM1,CHI3L1,CITED2,CNMD,COL1A1,COL2A1,COL7A1,CYP7B1,DNM1,DUSP1,EGR1,F2R,F3,FGF10,FOXP3,GLTP,HAS2,HDAC4,HGF,HPSE,IGF1,IL2RB,IRF3,ITGA2,ITGAD,JAM2,KDR,KLF4,LCAT,LPL,MAOB,MAT2A,MET,MMP2,MYCN,MYH7,NCF2,NOS1,NPTXR,NR5A2,PGK1,PKM,PREX1,PRKCD,PTGS2,RASGRP2,RBL1,RECK,SCTR,SERPINE1,SERPINH1,SGK1,SLC39A8,SLC9A3,SPARC,SREBF1,STAT1,TAGLN,TIMP1,TLR2,TNC,TNFRSF4,TNNC1,VIM,XYLT1 | 1601 (23) |
| SDC3 | -1.20e-01 | other | NA | -1.23e+00 | NA | 1.0e-02 | AXIN2,COL1A1,FZD1,MYOG,RUNX2 | 577 (7) |
| HDGF | -1.00e-01 | growth factor | NA | -1.23e+00 | bias | 2.0e-02 | COL1A1,PTGS2,SERPINE1,TGFB1 | NA |
| CCND1 | -2.57e+00 | transcription regulator | NA | -1.23e+00 | NA | 0.0e+00 | ABCC4,AFAP1,ALDH1A3,ARHGEF2,ASAP2,Bmyc,CALU,CCNA2,CCND1,CCND2,CCNE2,CD44,CD6,CDCA7L,CDH1,CDK2,CDK6,CDKN1A,CDKN2C,CENPF,CENPK,CLIC6,COL1A1,COL27A1,COL5A2,CPEB1,CPNE3,CTNNBIP1,DEPDC1,DONSON,E2F7,E2F8,EIF5A2,ELAVL1,ELOVL7,ENDOD1,ERRFI1,ESCO2,FGFR1,FLNA,GAS2L3,GATA4,HECTD2,HOMER2,HSPA1A/HSPA1B,IER3,ITGB3,KIF11,KIF4A,Klra2,KNL1,LASP1,MAFF,MARK1,MC4R,MCM7,MMP2,MORC4,MTMR1,MYBL1,MYO7A,NOP2,OVOL2,PDLIM4,PLK1,PMEPA1,PPARG,PTBP3,PTPRC,RBL1,RFC5,RGS2,RHPN2,SELENBP1,SLC4A4,SPC25,SPP1,STBD1,TMEM17,TMPRSS2,TOR3A,TUBB,TYMS,UAP1,UHRF1,USE1,UTRN,ZNF367 | 1374 (18) |
| RPTOR | 2.40e-01 | other | NA | -1.23e+00 | NA | 0.0e+00 | ACADL,ADGRE1,BCL3,CASP1,Ccl2,CCND1,CCND2,CD86,CDH1,CDK2,CDK6,COQ7,COX4I1,CSF1R,CTSK,CXCL12,DHCR7,DUSP6,EBP,EGLN1,FCGR1A,FGF2,GHITM,GPI,HIF1A,IFI44,Ifi47,IL1R1,IRF8,IRS1,LSS,LY75,Mbp,MRC1,MSMO1,MVD,MVK,MYOG,NLRP3,PKM,PPP1R3B,PTGS2,PYCARD,RTN4RL1,RUNX2,SIGLEC8,SLC2A1,SNAI1,SOCS3,SPRED1,SPRED2,SPTLC3,SREBF1,UCP3 | 1568 (22) |
| PRKAR2B | -1.49e+00 | kinase | NA | -1.23e+00 | NA | 1.0e-02 | BIRC3,EGR1,NR4A1,NR4A2,NR4A3,NTS,PPARG,PRKAR2B,TOP2A,TPO | NA |
| nicotinic acid | NA | chemical - endogenous mammalian | NA | -1.23e+00 | NA | 4.0e-02 | ABCA1,ABCG1,ADIPOQ,CD36,CEACAM1,ELOVL5,FABP1,G6PD,GAPDH,PPARG,UCP3 | NA |
| POSTN | -8.70e-01 | other | NA | -1.24e+00 | NA | 0.0e+00 | ACTA2,Ccl2,CDH1,DLK1,FN1,HEY2,LOX,LOXL1,LOXL2,MMP2,PDGFB,PTN,RUNX2,SPP1,TGFB1,TNNI1,VIM | 1453 (22) |
| 17-alpha-ethinylestradiol | NA | chemical drug | NA | -1.24e+00 | NA | 0.0e+00 | ABCC3,ADGRE1,ADGRE5,ALDH18A1,ARRDC3,ASNS,BCAT1,BCL3,C3,Ccl2,CCR1,CCR3,CCR5,CD53,CD74,CDH1,CDKN1A,CSF1R,CTSS,CXCL10,CYP7B1,F3,Gsta4,IFI16,IGF1,IL17RA,INHBB,KRT19,LPIN1,LY86,MET,MRC1,MRPS23,NR0B2,PLK3,SERPINH1,SESN1,SGK1,SLC38A3,Slco1a4,SOCS1,TNFSF8,TNNT1,UHMK1,VCAM1,WNT4 | 1997 (19) |
| ABCC1 | 7.00e-02 | transporter | NA | -1.24e+00 | NA | 0.0e+00 | CYBA,CYBB,NCF1,NCF2,NFE2L2,NOX1 | 611 (7) |
| KNG1 | NA | other | NA | -1.24e+00 | NA | 3.0e-02 | ASIC2,BDKRB2,CCND1,COL1A1,FGF2,IGF1,KDR,KLKB1,PTGS2,TGFB1 | NA |
| SERPINE1 | 6.40e-01 | other | NA | -1.24e+00 | NA | 0.0e+00 | ACTA2,ALDH8A1,ANKRD1,BCL6,CASP3,CDH1,CDKN1A,CHKA,CSF1,CXCL10,CXCL16,DBP,DLK1,DUSP1,DUSP6,EGR1,FGF2,FN1,FXYD6,GAP43,HBA1/HBA2,HGF,IER3,ITGB3,NFKBIA,PHLDA1,SYP,TGFB1,TLR2,UCP3,VCAM1,VIM,ZFP36,Zfp68 | 1601 (17) |
| palmitic acid | NA | chemical - endogenous mammalian | NA | -1.25e+00 | NA | 0.0e+00 | ACADL,ACSL1,ADIPOQ,AHR,ALDOA,AQP7,ATF3,BCL2L1,BCL2L11,BIRC3,C1QTNF9B,Casp12,CASP3,Ccl2,CD28,CD36,CD86,CDKN1A,CERS6,CKM,CNR1,CXCL10,CYBA,CYBB,CYP4F2,EEF1A1,EIF2AK3,ETV5,EZR,F2RL1,FABP1,FBXO32,FN1,FOLR2,FOXO1,G6PD,GAPDH,GCLC,GPAT3,HLA-A,HTR2B,HTR7,ICAM1,IGF1,IL1RN,INHBA,IRAK2,IRF3,IRS1,IRS2,KLF4,LPL,MAP1LC3A,MAP1LC3B,MET,Mt1,MVD,NCF1,NCF2,NCF4,NFE2L2,NFKBIA,NOX1,NR0B2,NR4A1,NR4A2,NR4A3,NSFL1C,NTN1,OLR1,PANX1,PDK4,PNPLA2,PNPLA3,PPARD,PPARG,PPARGC1B,PPP2R2B,Ppp2r3d,PRKAA1,PSMB5,PSMC1,PTGER3,PTGS2,RIPK3,RUNX2,SERPINE1,SHOX2,SOCS3,SORT1,SPHK1,SREBF1,TGFB1,THBD,TLR2,TLR4,TRIM63,VCAM1,VCP,VIPR2,WEE1 | 1400 (20) |
| USP29 | -7.00e-02 | peptidase | NA | -1.25e+00 | bias | 0.0e+00 | HIF1A,MYCN,PKM,RARA,SNAI1 | 1205 (10) |
| PRDX2 | 1.40e-01 | enzyme | NA | -1.25e+00 | NA | 4.0e-02 | CCND1,CDH1,FOXO1,FOXP3,ICAM1,PTGS2 | NA |
| PRKDC | 6.50e-01 | kinase | NA | -1.25e+00 | NA | 0.0e+00 | AHR,BIRC3,CCND1,CDKN1A,EGR1,EGR2,ITGB4,PIM3,PLA1A,PLK1,PREX1,TMPRSS2,VCAM1 | 1567 (21) |
| NDN | -8.90e-01 | transcription regulator | NA | -1.25e+00 | NA | 1.0e-02 | CDKN1A,DLK1,MYOG,PPARG,RBL1,SYP,WNT10B | 561 (7) |
| SOX2 | -1.50e-01 | transcription regulator | NA | -1.26e+00 | NA | 0.0e+00 | ABCC3,ACKR3,ACVR1,ADORA2A,AFAP1L2,AHR,ALDH1A1,ALOX5,APCDD1,AQP4,ARHGEF10,ATF3,AXIN2,BCAN,BCAS1,BCL2L1,BHLHE40,BMP4,CBFA2T3,CCNA2,CCND1,CD44,CD9,CDH1,CDH2,CDKN1A,CHST15,CHST3,CITED2,CNP,COBLL1,COL1A1,CSF1R,CTNNAL1,CXCL10,CXCL12,CXCL14,CXCR4,DKK3,DLL1,DOCK10,DUSP1,DUSP5,ECSIT,EFS,ELF1,ELOVL1,EMX2,ESRRB,ETV5,FA2H,FABP1,FAM107B,FARP1,Foxp1,FRZB,FYN,GAB1,GADD45B,GATA4,GBP4,GLI1,GLI2,GLTP,HOPX,ID2,IER5,IGF1,INHBA,IRF6,IRS1,JAG1,KDM3A,KDR,KIF19,KITLG,KLF4,KLF6,KRT19,LAMP2,LBX1,LEF1,LIMA1,LIMS2,LMCD1,LPAR1,LRRC4,MAG,MAX,MOG,MYCN,MYRF,NAAA,NDN,NOTCH4,NR5A2,NRARP,NRP1,NSFL1C,Oasl2,OPALIN,PARD6G,PCDH18,PDGFRA,PHLDB1,PIK3R1,PIK3R3,PITX2,PLD1,PLP1,PLXNB3,POLE4,PPARG,PRDM1,PRKCD,PRKCQ,PROM1,RASGEF1B,RNF43,S100A13,SALL4,SEMA3D,SEMA5A,SERPINE1,SIRT2,SLC44A1,SMOC1,SNAI1,SNX18,SOSTDC1,SOX10,SOX6,SOX8,SPP1,SPRY4,STRA6,TAF1C,TBX3,TEC,TGFB1,TM7SF3,TMEM63A,TNFRSF19,TNNI1,TP63,TSPAN2,TWIST1,TWIST2,UGT8,USP18,UST,VCAN,VEGFC,VIM,WIPF1,WLS,WNT5A,ZFP57 | 1614 (28) |
| ZBTB16 | 2.12e+00 | transcription regulator | NA | -1.26e+00 | NA | 0.0e+00 | ACER2,ATP6V1A,B3GNT2,BCL6,CASP3,Ccl2,Ccl7,CCNA2,CCND1,CD180,CD200R1,CD244,CD34,CD44,CD74,CD83,CD86,CDKN1A,COL1A1,CSGALNACT1,CXCL10,DTX1,EGR2,EMB,EYA2,F13A1,F2R,F2RL1,FOXO1,GATM,GBE1,GPT2,H6PD,HOXD10,HOXD9,HPSE,HRAS,ID2,IL10RA,IL17A,IL18R1,IL2RA,IRF6,ITGAE,ITGB3,KIT,KLHL6,LTB4R,LY86,MAF,ME3,PDGFB,PIK3R1,PIK3R3,Pla2g12a,PLA2G5,POLA2,POLE3,PTGS2,RARG,REL,RUNX2,SELP,SLC2A1,SPP1,TMEM176B,TNFRSF25,TNFRSF4,TNFSF8,ZBTB16 | 1466 (21) |
| PIK3R1 | 1.27e+00 | kinase | NA | -1.26e+00 | NA | 0.0e+00 | ACTA2,ATP1A1,BCL2L1,CCND1,CCND2,CD36,CD44,CXCL10,CXCL12,ENG,ERBB3,F3,FOXO1,GCH1,HIF1A,ICAM1,ISG15,MAFA,MITF,MKI67,MMP2,NFE2L2,PDGFRA,PIK3R1,PKM,PPARG,PTGS2,SELP,SERPINE1,SLC2A1,TGFB1,VCAM1,VEGFC | 1509 (18) |
| carbenoxolone | NA | chemical toxicant | NA | -1.26e+00 | NA | 1.0e-02 | BCL2L11,COL1A1,COL3A1,CYBA,EDN3,LOX,NOX4,PTGS2,SPP1,SREBF1,TIMP1 | 1280 (22) |
| mitomycin C | NA | chemical drug | NA | -1.26e+00 | NA | 2.0e-02 | ATF3,BCL2L1,BCL2L11,BRCA2,BTG2,CASP3,CCND1,CDKN1A,EGR1,GADD45A,HGF,IRF2BP2,ITPRIPL2,PRKCE,PYCARD,TP63,TULP4,WEE1 | NA |
| PRPF19 | 5.10e-01 | enzyme | NA | -1.26e+00 | NA | 2.0e-02 | CDKN1A,GFAP,GPAM,PLIN1,PLIN4 | NA |
| PLK2 | -1.14e+00 | kinase | NA | -1.26e+00 | NA | 1.0e-02 | Ccl7,CITED2,CXCL10,EDN1,FGL2,IL15RA,IRF1,PLAT,RBL1,RGCC | NA |
| PPARA | 1.80e-01 | ligand-dependent nuclear receptor | NA | -1.27e+00 | NA | 0.0e+00 | ABCA1,ACADL,ACADS,ACOT8,ACSL1,ACSL5,ACTA1,ADAM10,ADIPOQ,Akr1b7,ALDH9A1,ANXA2,AQP7,ARG1,ASNS,BCL2L1,BDNF,C1R,C2,C3,C6,CA9,Ccl2,CCNA2,CCND1,CD36,CDK2,CDKN1A,CDKN2C,CEACAM1,CEBPD,CFH,CFI,CHKA,COX4I1,CTSE,CXCL12,CYBA,CYBB,CYP27A1,CYP7B1,DHCR7,DIO1,DYNLL1,ECH1,EDN1,ELOVL5,ENTPD1,ETHE1,FABP1,FADS1,FADS2,FITM1,G0S2,G6PD,GLUL,GPAM,GPD1,GPD2,Gsta4,HGF,HIF1A,HLA-DQA1,HMGN1,Hmgn2 (includes others),HPD,HSD17B4,IFITM3,IGFBP5,IGFBP6,IL17A,IL1RN,KHK,KIF4A,LIPG,LPL,LSS,MAT2A,ME2,MGST1,mir-143,MKI67,MSMO1,MVD,MVK,NCF1,NCF2,NFE2L2,NFKBIA,NTHL1,OCLN,PAQR9,PC,PCTP,PDK4,PHLDA1,PLA2G2A,PLA2G7,PLIN1,PLIN4,PLK1,PLTP,PNPLA2,PPARD,PPARG,PRC1,PRDM16,PTGS2,QPCT,RBP7,RETN,SELENBP1,SLC27A1,SMC2,SORD,SREBF1,STBD1,TLR2,TLR5,TOP2A,TP63,UCP3,VCAM1,YWHAQ | 1164 (21) |
| SLC16A2 | -9.20e-01 | transporter | NA | -1.27e+00 | NA | 1.0e-02 | CNTN2,DGKG,DIO1,IER5,KLF9,MARCKSL1,SCUBE1,SEMA7A,SLC16A1,SLC16A3,SLC7A8,SLCO3A1,UCP3 | 503 (7) |
| VTN | 1.30e-01 | other | NA | -1.28e+00 | NA | 0.0e+00 | BCL2L1,BHLHE40,CDKN1A,COL1A1,F3,IRF8,IRS1,ITGA4,ITGA5,MMP2,PTGS2,RUNX2,S100A10,SERPINE1 | 1465 (21) |
| THBS4 | -2.16e+00 | other | NA | -1.28e+00 | NA | 1.0e-02 | Ccl2,CDH1,CDH2,COL2A1,COL3A1,CXCL10,ICAM1,MTHFD2,SELE,TNC,VCAM1,VIM | 1415 (20) |
| RTN4 | -1.00e-01 | other | NA | -1.28e+00 | NA | 0.0e+00 | ADIPOQ,BDNF,CFL1,CPLX1,DPYSL2,FGF1,GAP43,GFAP,GNG2,JUND,MAP2,MAPRE3,MYL2,NEFL,PEA15,RAB3D,STAT1,Tpm1,TRPV1,TSPAN2,TUBB4A,YWHAQ | 1164 (16) |
| ADORA2B | -3.30e-01 | G-protein coupled receptor | NA | -1.28e+00 | NA | 2.0e-02 | ARG1,Ccl2,CCND1,CD86,HIF1A,KLF4,MRC1,PDE5A,RUNX2,SERPINE1,SKP2,SPP1,TGFB1,TIMP1 | NA |
| HDAC2 | -2.00e-01 | transcription regulator | NA | -1.28e+00 | NA | 0.0e+00 | ACTA2,ALOX5,BCL6,CCND1,CCNE2,CD34,CDH1,CDK2,CDKN1A,COL11A1,COL1A1,COL2A1,CYBB,EGR1,EZH2,F3,FABP1,FAM107A,GABARAPL1,GLI1,IGF1,INPP5F,ITGAD,LGR5,MCM7,MPZ,MYCN,MYO1F,NFKBIA,PAX3,PDGFB,POLE4,PREX1,PTGS2,SFRP1,SLC35D1,SOX10,TAGLN,TNFRSF19,TNNI2,TP63,TRPC6 | 1488 (25) |
| ECM1 | -9.70e-01 | transporter | NA | -1.28e+00 | NA | 4.0e-02 | ARG1,CDH1,ECM1,S100A4,SNAI1,SNAI2,VIM,ZEB2 | NA |
| ERBB3 | -1.88e+00 | kinase | NA | -1.28e+00 | NA | 0.0e+00 | ACTA1,ACTA2,Actn3,ADAM19,AXL,BGN,CCND1,CCND2,CD47,CDH1,CDKN1A,CDKN2C,CMA1,COL1A1,CTSK,CXCL12,CXCR4,DUSP1,EGR1,EIF6,EMP2,ERBB3,ETV5,EZR,F3,FBN1,FGF2,FN1,FSTL1,HAS2,HBA1/HBA2,HIF1A,IGFBP5,ITGB2,LAMA4,MATN2,NID1,PHGDH,PLK1,PTGS2,SERPINE1,SFRP1,SGK1,SNAI1,SOCS3,SPARC,STMN1,THBS1,TNC,TNNT2,TOP2A | 1507 (19) |
| CDCP1 | -5.00e-01 | other | NA | -1.29e+00 | NA | 2.0e-02 | CCND1,CD44,CDH1,MMP2,VIM | NA |
| VitaminD3-VDR-RXR | NA | complex | NA | -1.29e+00 | NA | 1.0e-02 | CALB1,CDKN1A,COL13A1,CXCL10,FOXO1,GADD45A,IGFBP5,IGFBP6,IL1RL1,KLF4,PPARD,SEMA3B,SPP1,THBD | NA |
| MYBL2 | 9.00e-02 | transcription regulator | NA | -1.29e+00 | NA | 1.0e-02 | BCL2L11,BIRC3,BUB1,CCNA2,CCND1,CDC25B,CDK2,ELN,IGFBP5,IQGAP1,MAD1L1,PLK1,PPP3CA,SLC1A5,TOP2A | NA |
| mannitol | NA | chemical - endogenous mammalian | NA | -1.29e+00 | NA | 0.0e+00 | AQP4,BCL2L11,Ccl2,COL1A1,FN1,FOXO3,HDC,ICAM1,TRPV4 | 1257 (18) |
| crocidolite asbestos | NA | chemical toxicant | NA | -1.29e+00 | bias | 2.0e-02 | BCAT1,Ccl2,CCND1,CD44,GADD45A,GCLC,JUND,MET,PRKCD,SPP1 | NA |
| TGFA | -2.40e+00 | growth factor | NA | -1.30e+00 | NA | 0.0e+00 | BCL2L1,BIRC3,CASP1,CCND1,CDKN1A,CXCL10,ERRFI1,GFAP,GJB2,HGF,ICAM1,IGFBP4,LAMC2,NR4A2,PLA2G4A,PLA2G5,PLAGL1,PLAT,PTGS2,S100A10,SERPINE1,TGFA,TGFB1,TLR5,VIM,WNT5A | 1361 (17) |
| HOXD8 | NA | transcription regulator | NA | -1.30e+00 | NA | 4.0e-02 | ANGPT2,CCNA2,HOXD10,HOXD9,PROX1 | NA |
| PDPK1 | 2.60e-01 | kinase | NA | -1.30e+00 | NA | 4.0e-02 | A2M,ALOX5,CAV1,CCND1,CD47,CDKN1A,CXCL10,FOXO1,FOXO3,PROM1,SERPINE1,SNAI1 | NA |
| PPP2CA | -5.40e-01 | phosphatase | NA | -1.30e+00 | NA | 0.0e+00 | AHR,BCL2L11,CASP1,Ccl2,CCND1,CD36,CDKN1A,CFB,CXCL10,EIF4EBP1,ENTPD1,FOXO3,FOXP3,HCAR2,IL17A,IL2RA,IL2RB,IL2RG,IRF1,ITGAL,MYL1,NOVA1,PTGS2,PTPRC,RPS6KB1,SOCS1,SOCS3,STAT1 | 843 (17) |
| ESRRG | -1.39e+00 | ligand-dependent nuclear receptor | NA | -1.30e+00 | NA | 0.0e+00 | ACO2,ACTA1,ACTC1,ACTN2,ATP2A2,CASQ2,CDKN1A,CREBZF,CSRP3,Esrra,FBXO32,FGF1,GAPDH,HGF,IDH3A,IL17A,IL7,KCNH2,KCNJ11,LPIN1,LPL,MB,MDH1,MYBPC3,MYH6,MYH7,MYL2,MYL3,NR0B2,NRP1,PDK4,PKM,SSPN,TNNC1,TNNT2,TRIM63,UCP3 | 1418 (17) |
| BCR (complex) | NA | complex | NA | -1.30e+00 | NA | 0.0e+00 | ALDOA,APBB1IP,ARAP2,ASNS,ATF3,ATP6V0B,ATP6V1E1,ATP6V1F,B4GALT1,BANK1,BATF,BCL2A1,BCL2L1,BCL2L11,BCL3,BCL6,BTK,BYSL,C15orf48,CACNA1I,CASP3,CCNA2,CCND1,CCND2,CD22,CD44,CD7,CD86,CDK2,CDK6,CDKN1A,COX6B1,CTSS,CXCR4,CXCR5,DCTPP1,EGLN2,EGR1,EGR2,ELOVL5,EXOSC5,FAM107B,FCGR2B,FCMR,FOXO1,GAPDH,GBP2,GPI,GPR183,GRWD1,GZMB,HK1,HSPE1,ICAM1,IL2RA,IL2RB,IMP4,IRF4,IRF5,IRF8,ITGA4,KLF4,KLF9,LGALS9B,MAPK3,MS4A6A,NDUFA7,NDUFAB1,NDUFB3,NDUFB9,NOP16,NOP2,PES1,PKIB,PLA2G5,PLEK,POU2F2,PPP1R18,PRDM1,PTAFR,PTGS2,PUS1,RAC2,REL,RHOF,RRP9,S100A10,SAMSN1,SIGLEC10,SLC1A5,SLC2A1,SLC38A1,SLC38A2,SORD,STAT1,TCOF1,TES,TLR10,TLR7,TNFRSF25,TNFSF8,TRIB1,ZBTB16,ZNF608 | 1436 (22) |
| TRIM29 | -6.50e-01 | transcription regulator | NA | -1.30e+00 | NA | 2.0e-02 | CD44,CDKN1A,CXCR4,PROM1,SNAI1 | NA |
| CBR3-AS1 | NA | other | NA | -1.30e+00 | NA | 0.0e+00 | CCND1,CDH1,CDH2,TGFB1,VIM | NA |
| FSH | NA | complex | NA | -1.30e+00 | NA | 0.0e+00 | ACP5,ACTA1,ACTA2,ACTG2,ADAM17,ADAMTS1,ADCY7,AHR,AKAP12,AKAP7,Akr1b7,APLN,ARHGEF5,ATP2A2,ATP9A,AXIN2,AXL,BCL11A,BDNF,BTG2,CCND1,CCND2,CDC42EP4,CDH2,CDK14,CDK6,CLEC11A,COL18A1,CREBZF,CREM,CRYM,CX3CL1,CXCR4,DAB2,DAPK1,DHCR7,DHH,DUSP1,ELL2,ENC1,EZR,FGF2,FGFR1,FKBP5,FOXO1,GATA4,GCLC,GNAS,GRK5,GZMB,HIF1A,HSF2,ID4,IGFBP4,IL1RN,INHA,INHBA,INHBB,ITGA3,ITGA5,KITLG,KLF10,LGALS1,LOX,MAP1LC3B,MAPK14,MMP2,MSMO1,MYRF,NR4A1,NR5A1,PAWR,PENK,PGK1,PGRMC1,PKM,PLA1A,PLAT,PLCL1,PLIN3,PLK2,POP5,PRKD1,PRKX,PSIP1,PTGS2,PTPRF,RAB27A,RAB2A,RAB31,RAP1GAP,RARA,RASSF2,RGS4,RGS7,SERPINE1,SGK1,SLC2A1,SMAD6,SMAD7,STAR,STAT1,STX4,TFPI2,THBS1,TIMP1,TNFAIP6,TNFRSF11B,TRIB1,TUBA1A,TYRO3,VEGFC | 1794 (18) |
| USP28 | -1.80e-01 | peptidase | NA | -1.31e+00 | NA | 1.0e-02 | CASP3,CCND1,CDKN1A,GATA4,PLK3,SNAI1 | 1422 (18) |
| phospholipid | NA | chemical - endogenous mammalian | NA | -1.31e+00 | NA | 2.0e-02 | ALOX5,Ccl2,CXCL10,F3,PTGS2 | NA |
| EIF2AK4 | 4.30e-01 | kinase | NA | -1.31e+00 | NA | 3.0e-02 | AQP4,ASNS,ATF3,ATP2A2,CD36,CHAC1,DDIT4,EGR1,MOG,NFE2L2,PHGDH,PLP1,PPARG,PRDM1,PYGL | NA |
| ketamine | NA | chemical drug | NA | -1.31e+00 | NA | 0.0e+00 | BDNF,CASP3,CREM,GAD1,GFAP,HK1,KLF6,NR4A1,PTGS2,PVALB | 1151 (21) |
| FERMT2 | 3.60e-01 | other | NA | -1.31e+00 | bias | 0.0e+00 | ACTA2,Ccl2,CCND1,COL1A1,FN1,FOXO1,GLI1,SREBF1 | 1356 (23) |
| KPNA2 | -3.80e-01 | other | NA | -1.31e+00 | NA | 1.0e-02 | IFIT1,ISG15,ITGA6,LOXL2,SNAI1,SPARC | NA |
| DUX4 | NA | transcription regulator | NA | -1.31e+00 | NA | 1.0e-02 | ACTC1,BIN1,CCND1,CCND2,CHRNA1,CRYM,E2F7,FBXO32,FZD1,FZD2,FZD4,IGFBP5,MYOD1,MYOG,SIX1,TRIM63,WNT5A | NA |
| TAF4B | -1.60e-01 | transcription regulator | NA | -1.32e+00 | bias | 0.0e+00 | CCND2,FN1,IER3,INHA,INHBA,INHBB,IRF1,ITGA6,NFKBIA,RET,SPP1,TGFB1,ZBTB16 | NA |
| STAT1/3/5 dimer | NA | complex | NA | -1.32e+00 | bias | 0.0e+00 | BCL2L1,BCL3,CEBPD,CHI3L1,CISH,CRP,IRF1,LBP,SOCS3,TIMP1 | NA |
| LRPAP1 | 2.70e-01 | other | NA | -1.32e+00 | NA | 0.0e+00 | ACTA2,Ccl2,CDH1,F3,LPL,MAPK3,MMP2,PTGES,PTGS2,SERPINE1 | 1300 (17) |
| CD83 | -1.69e+00 | transmembrane receptor | NA | -1.32e+00 | NA | 3.0e-02 | ACP5,CD36,CD86,CTSK,FOXP3,KLF4,MRC1,MRC2,MSR1,PTGS2 | NA |
| IL24 | -2.80e-01 | cytokine | NA | -1.32e+00 | NA | 3.0e-02 | BCL2L1,BCL2L11,BCL6,CASP3,CASP8,Ccl2,CCND1,FADD,FOXP3,GADD45A,GADD45G,IRF4,PRDM1,PTGS2 | NA |
| MTDH | 3.10e-01 | transcription regulator | NA | -1.32e+00 | NA | 0.0e+00 | CASP3,CASP8,CDH1,CDH2,CDKN1A,DIO1,DPYD,FABP1,HIF1A,MMP2,NR0B2,SOCS1,TEK,TWIST1,TYMS,VIM | 994 (13) |
| methylselenic acid | NA | chemical reagent | NA | -1.33e+00 | NA | 0.0e+00 | ABCC4,ACKR3,ACSL3,ACTN4,ADAMTS1,ADD3,APOD,ATF3,B4GALT1,BACH1,BCL2A1,BCL2L1,BIRC3,BLVRB,BMP4,BRCA2,BUB1B,CCNA2,CCND1,CD44,CDC14B,CDC25B,CDK2,CDKL1,CDKN1A,CENPF,CORO1A,CREB1,DPYSL2,DUSP10,DYNLL1,E2F5,EPHX1,ERCC1,ERP44,FKBP5,FN1,GADD45A,ID2,IGF1,INPP4B,IRF1,ITGB4,KIF11,KLF4,KLHL2,LMNB2,MAP1B,MAPK14,MAPK3,MATN2,MCM7,MKI67,NAT2,NEDD4L,NFIL3,NMI,PDIA4,PLK1,POLA1,PPM1A,PPP5C,PTGES,RAB28,RAB31,RABAC1,RAPGEF4,RFC5,RGS10,RND3,SEC24D,SGK1,SNAI2,TLR2,TMPRSS2,TNFRSF25,TOP2A,TYMS,UGDH,VEGFC,ZBTB16 | 1815 (20) |
| PTBP3 | -8.20e-01 | other | NA | -1.33e+00 | NA | 1.0e-02 | CDH1,CDH2,FN1,VIM,ZEB2 | NA |
| ascorbic acid | NA | chemical - endogenous mammalian | NA | -1.33e+00 | NA | 0.0e+00 | ACTA2,BCL2L1,CASP8,CDKN1A,COL1A1,DMP1,DUOX2,FTL,GLI1,HIF1A,IGF1,IGFBP4,IGFBP5,ISCU,ITGA1,ITGA2,ITGB3,PMP22,PPARG,PRKCD,PTCH1,PTGS2,RUNX2,SERPINE1,SLC20A1,SLC2A1,SPARC,SPP1,TGFB1,TNFRSF11B | 1222 (17) |
| CREB1 | -8.80e-01 | transcription regulator | NA | -1.34e+00 | NA | 0.0e+00 | ABCA1,Abca8a,ADGRA1,ADORA2A,AK4,ARG1,ARHGAP33,ATF3,ATP1A1,ATP2B4,ATP6V0B,BCL2L1,BDNF,BHLHE22,BHLHE40,BTG2,CAMK1D,CAPN5,CCNA2,CCND1,CD9,CDH11,CDH2,CDK14,CDKN1A,CEBPD,CGREF1,CHRNA1,CIART,CIITA,CLMP,CNN1,CPEB1,CREB1,CREM,CRYM,CSRNP1,CSRP2,CXCR4,DMBT1,DUSP1,EBP,ECM1,EDIL3,EDN1,EGR1,EGR2,EHD4,ENTPD1,ERRFI1,ESRRG,FAM3B,FGL2,FN1,FOXO3,FOXP3,FUT7,GAD1,GADD45A,GADD45B,GADD45G,GAP43,GDA,GDF11,GFRA1,GNAL,GPNMB,H2-T22,HAS2,HERPUD1,HLA-A,HLA-DRA,HOMER1,HTR2A,IER3,IGSF10,IL2RA,INHA,INHBA,IRS2,ITGBL1,KCNC4,KDELR3,KIAA1549L,KLF4,KLF5,LAPTM4B,LAYN,Ldha/RGD1562690,LITAF,LMO1,LPL,LSS,LYPD6,MARCKSL1,MAT2A,MCTP1,MIDN,MKI67,MRC1,MRPS18B,MSMO1,MTSS1,MVD,MVK,MYH10,NAB2,NARF,NDUFV1,NECTIN3,NFIL3,NOS1,NR4A1,NR4A2,NR4A3,NRP1,NRP2,PAM,PCDH11X,PDE1C,PDE3B,PDGFRA,PENK,PER1,PGM2L1,PIM3,PLA2G4A,PLAT,PNMT,POLE4,PPARG,PRCP,PTGS2,RASGEF1B,RASGRF1,RERG,RGS2,RP1,RUNX1T1,SCN3B,SEMA4A,SEMA7A,SFRP4,SFTPB,SGK1,SHTN1,SIAH2,SIK3,SLC16A1,SLC18A2,SMAD6,SMPD3,SPHKAP,SREBF1,STAR,STMN1,STRBP,TACR3,TAGLN2,TCEAL9,TIPARP,TMBIM1,TPO,TRPC6,TSHR,TSKU,VIM,WDR90,ZFP36,ZFPM2 | 1437 (20) |
| HBEGF | -1.20e-01 | growth factor | NA | -1.34e+00 | NA | 1.0e-02 | ALDOA,BCL3,BHLHE40,CCND1,CCND2,CDH1,CSF1R,CXCR4,EGR1,ELN,FGF2,MAPK14,NRP1,PDK4,PKM,PTGS2,SLC16A3,TGFA | 1515 (20) |
| GRHL2 | -5.10e-01 | transcription regulator | NA | -1.34e+00 | NA | 1.0e-02 | ARHGEF28,CDH1,CXCL13,ERBB3,IL7,MMP14,NRP2,OCLN,SEMA3B,SEMA3C,TP63 | NA |
| CCDC12 | 4.80e-01 | other | NA | -1.34e+00 | NA | 0.0e+00 | CDH1,FN1,MMP2,SNAI1,VIM | NA |
| EXT1 | -6.60e-01 | enzyme | NA | -1.34e+00 | NA | 0.0e+00 | BMP4,CCND1,CEBPD,FGF1,FN1,HPSE,KLF15,PLIN1,PPARG,SLC27A1,SREBF1 | 1393 (19) |
| TMPO | -7.00e-02 | other | NA | -1.34e+00 | bias | 0.0e+00 | COL11A1,COL12A1,COL1A1,COL3A1,MMP15 | NA |
| GPC1 | 2.60e-01 | transmembrane receptor | NA | -1.34e+00 | bias | 0.0e+00 | CX3CL1,GNA13,ITGB3,MYOD1,MYOG,PTGS2 | 1242 (15) |
| PHF10 | -1.70e-01 | other | NA | -1.34e+00 | NA | 0.0e+00 | CASP3,CCNE2,ETS1,FOXP3,TYMS | NA |
| NEK7 | 6.00e-02 | kinase | NA | -1.34e+00 | NA | 1.0e-02 | CXCL10,EDN1,ISG15,PTGS2,RGCC | 713 (10) |
| NEK6 | -7.90e-01 | kinase | NA | -1.34e+00 | bias | 1.0e-02 | CITED2,CXCL10,FGL2,PTGS2,RILPL1 | 703 (7) |
| mir-541 | NA | microRNA | NA | -1.34e+00 | NA | 2.0e-02 | CCND1,CDH1,CDH2,MMP2,VIM | NA |
| NF 449 | NA | chemical reagent | NA | -1.34e+00 | NA | 2.0e-02 | GLI1,GLI2,GZMB,MYCN,PTCH1 | NA |
| RFC4 | 0.00e+00 | enzyme | NA | -1.34e+00 | bias | 2.0e-02 | ALDH1A1,CCND1,CDH2,NRARP,TWIST1 | NA |
| IGFBP7 | -6.30e-01 | transporter | NA | -1.34e+00 | NA | 3.0e-02 | ASNS,CASP3,CCND1,CDKN1A,MMP2,PTGS2 | NA |
| BMP | NA | group | NA | -1.35e+00 | NA | 3.0e-02 | DPYSL2,ERBB3,GATA4,ID2,IRF1,KDR,PAX3,RUNX2,SPP1 | NA |
| PRMT5 | 4.40e-01 | enzyme | NA | -1.35e+00 | NA | 3.0e-02 | ADIPOQ,AXIN2,CCND1,CXCL10,KLF4,PER1,PPARG,PRDM1,PTPRO,PTX3,RETN,SLC45A3,SMAD7,SOSTDC1,SREBF1,STAT1 | NA |
| CGB3 (includes others) | NA | other | NA | -1.35e+00 | NA | 1.0e-02 | DUSP6,IL17A,MMP2,PTGS2,RUNX1,SGK1,TNFAIP6 | 1085 (11) |
| 25-hydroxycholesterol | NA | chemical reagent | NA | -1.36e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACSL1,APOD,ASNS,ATF3,CCND1,CHAC1,CYP4F2,EIF2AK3,GPX3,HIF1A,JUND,MAFF,NFKBIA,NR4A1,NR4A2,NR4A3,PIK3R3,PTCH1,PTGS2,SREBF1 | 1271 (23) |
| POU4F1 | 2.40e-01 | transcription regulator | NA | -1.36e+00 | NA | 0.0e+00 | ACTC1,ADGRG2,BCL2L1,CACNB3,CDKN1A,CLIC6,CNTN2,DAB1,ETV1,ETV5,EYA1,GNAS,HOXB5,Irx5,KCNIP1,LILRB3,MSI2,MYL1,NOVA1,NR4A2,NTRK2,PAPPA2,PIEZO2,Pmaip1,PVALB,RET,RGMA,RUNX1,SCN7A,TFAP2B,TRPV1 | NA |
| MAK683 | NA | chemical drug | NA | -1.36e+00 | NA | 2.0e-02 | CXCL12,FOXO1,GATA4,IGFBP5,ITGA2,MET,MKI67,MMP2,TBX3,WNT6 | NA |
| TCF | NA | group | NA | -1.36e+00 | bias | 0.0e+00 | ADGRG2,ALDH1A1,APOD,BCL2L1,BMP4,CCND1,CD44,CEACAM1,ECM1,EDN3,EGR1,F13A1,FGF9,GAD1,IL1R1,INHBB,IRS1,ITGA1,LEF1,LGR5,LMO2,MME,MMP2,NRCAM,PLS3,PTCH1,PTGS2,QPCT,SEMA3C,SERPINE1,SLC1A5,TOB2,TSPAN8,UGCG | 1343 (13) |
| NCOA3 | 4.00e-01 | transcription regulator | NA | -1.36e+00 | NA | 0.0e+00 | AHR,AMPD1,ANKRD1,CCDC80,CCNA2,CCND1,CCNE2,CDK2,CDKN1A,ESRRB,FGF2,GJB2,IGF1,IRF1,IRS1,KDR,MCM7,NFKBIA,PGK1,PPARD,PPARG,PTGS2,SALL4,SFTPB,SLC16A3,SLC2A1,SREBF1,TAGLN,TKT | 1519 (22) |
| PRRX1 | -8.00e-02 | transcription regulator | NA | -1.36e+00 | NA | 0.0e+00 | ANGPT2,FGF1,HIF1A,MAP1LC3B,PALLD,PDGFB,PPARG,PROM1,TGFB1,TNC,VEGFC | 1296 (12) |
| MDM2 | 2.00e-02 | transcription regulator | NA | -1.37e+00 | NA | 0.0e+00 | ADGRE1,ATF3,Ccl2,CCNA2,CCND1,CCNE2,CDKN1A,EDA2R,ELF4,ETS1,EZH2,FCGRT,FOXO3,H2AC18/H2AC19,HIF1A,IGFBP6,IL1RN,INHBB,MCM7,MYCN,NDUFA1,NR0B2,NR5A1,RABAC1,RPL23,SERPINE1,SNAI2,THBS1,TIMP1,TOP2A,TP63 | 1383 (19) |
| desmopressin | NA | biologic drug | NA | -1.37e+00 | NA | 0.0e+00 | ADD3,ATP1A1,CGNL1,CYBA,FLNA,GAPDH,HINT1,HSPA1A/HSPA1B,LDHB,LIMA1,MME,MYH10,NFAT5,PALM,PHLDB2,PLS3,PPIA,PPP1R1A,RAP1GAP,RHOA,RPL23,RPS3,S100A11,SCNN1G,SLC9A3,SNX3,SORT1,SPTBN2,ST14,Tpi1 (includes others),TUBB,VWF,YWHAQ | NA |
| carbamazepine | NA | chemical drug | NA | -1.37e+00 | bias | 1.0e-02 | ASNS,ATF3,BACH1,BCAT1,BDNF,DNAJB1,EIF4EBP1,HERPUD1,JAG1,JUND,KLF9,MAP1LC3B,MTHFD2,OSMR,SLC7A1,UGT1A4 | NA |
| OSMR | -6.50e-01 | transmembrane receptor | NA | -1.37e+00 | NA | 0.0e+00 | ADGRE1,BCL3,BIRC3,C15orf48,Ccl2,CISH,CXCL10,DHX58,GAP43,GBP2,GBP4,GBP5,Ifi47,LBP,LRG1,Oasl2,OSMR,SBNO2,SOCS1,SOCS3,SREBF1,TIMP1,ZFP36 | 1037 (16) |
| USF1 | 1.20e-01 | transcription regulator | NA | -1.37e+00 | NA | 1.0e-02 | ABCA1,ACP5,AKAP12,APLN,B2M,BRCA2,CEACAM1,CHI3L1,CIITA,CTSS,DUSP1,FBXO32,GPAM,HDAC4,HGF,Mt1,NR5A1,PGK1,PTGS2,SERPINE1,SPEG,SPP1,TGFB1,USF2 | NA |
| CAV1 | -6.00e-01 | transmembrane receptor | NA | -1.37e+00 | NA | 0.0e+00 | ACVRL1,ADAM17,ADGRG2,ARG1,BCL2L11,CAV1,CAV2,CCND1,CD276,CD36,CD86,CDH1,CDKN1A,CSF1R,CXCL10,EDIL3,EGR1,FGF2,FN1,GIPC2,HGF,HSD17B12,ICAM1,INHBA,INHBB,KDR,KRT19,NEDD4L,NR4A1,NTRK2,OCLN,OSBPL7,PDK2,PLA2G4A,PROM1,RPL17,SERPINE1,SLC1A1,SLC20A1,SMAD6,SNAI1,SNAI2,ST6GAL1,TGFB1I1,THBS1,TNC,TXNL4A,VCAM1,VIM,WNT6 | 1421 (17) |
| ITGB6 | 1.60e-01 | other | NA | -1.37e+00 | NA | 1.0e-02 | CDH1,COL1A1,COL3A1,MMP2,RHOA,SERPINE1,TGFB1 | NA |
| TNC | -2.11e+00 | other | NA | -1.37e+00 | NA | 0.0e+00 | CASP1,Ccl2,CDH11,CDKN1A,COL2A1,CXCL12,ID2,KHDRBS1,LGR5,Mbp,MET,MMP14,MMP2,MSI1,RHOA,TLR4 | 1198 (19) |
| SPP1 | -1.46e+00 | cytokine | NA | -1.38e+00 | NA | 0.0e+00 | ADIPOQ,ARG1,BCL2L1,BCL2L11,CASP8,Ccl2,CCND1,CCS,CD44,CD9,CDH1,CDH2,CDK2,CDKN1A,COL1A1,CXCL12,CYP39A1,DHCR7,EGF,FN1,GATA4,GFAP,HAS2,HOMER2,ICAM1,IGF1,IL17A,ITGA2,ITGA3,ITGB3,JAG1,KRT19,LOX,MET,MMP14,MMP2,NDUFB9,NDUFS7,NDUFV1,NOX1,NRCAM,OCLN,PIK3R1,PPARG,PROX1,PTGS2,RUNX2,RXRG,S100A4,S100A6,SERPINE1,SERPINF1,SLC35C2,SNAI1,SNAI2,SOX8,SPP1,TGFB1,TIMP1,VAT1,VIM | 1340 (18) |
| MAPK3 | -6.90e-01 | kinase | NA | -1.38e+00 | NA | 0.0e+00 | B4GALT1,BCL2L11,BMP4,CCND1,CD86,CDKN1A,COL3A1,EGR1,EGR2,ELN,FN1,FOXP3,HDC,HOMER1,IL2RA,ITGA2,JUND,MYRF,NFE2L2,NR4A1,PDGFB,PLA2G4A,PTGES,PTGS2,RET,RGS2,SELE,SPP1,THBS1,TIMP1,TNFRSF10A | 1323 (18) |
| KDR | -9.80e-01 | kinase | NA | -1.38e+00 | NA | 0.0e+00 | A2M,ANGPT2,ANXA2,BTK,Ccl2,CXCR4,F3,INPP5D,KDR,MMP14,NR4A1,PTGS2,S1PR2,SELE,SFRP1,SNAI2,SOX18,TAL1 | 1285 (17) |
| STAT5B | 6.10e-01 | transcription regulator | NA | -1.38e+00 | NA | 0.0e+00 | A2M,ACOT11,ACTC1,AGPAT2,ANKRD1,Aox3,ATP2A2,BAIAP2,BCL2L1,BCL6,BIRC3,CASP3,CASP8,CCDC141,CCND1,CCND2,CD276,CD9,CDH1,CDK6,CDKN1A,CDO1,CISH,CITED2,COX6A2,Cox8b,CSRP3,CUX2,CYP26B1,CYP39A1,DAPK1,DUSP1,EBF1,FBLN1,FMO2,FOXP3,G0S2,GABARAPL1,GADD45A,GADD45B,GCNT2,GLUL,GPD1,GPX7,Gsta4,H2-T22,HLA-A,IFITM3,IGF1,IGFALS,IL2RA,IL2RB,IRF1,IRF8,JUND,KLF9,KRT19,LAMA3,LDHB,LIMD2,LMO2,MAF,MB,METTL7A,MMRN1,MOXD1,MTMR11,MYCN,MYCT1,MYH6,MYH7,MYL1,MYL2,NIPAL1,NNMT,NOX4,NR4A2,NRP2,NUCB1,Oasl2,OBSCN,Pcp4l1,PCSK5,PDK4,PDZRN3,PLTP,PMM1,POU2F2,PPP1R3C,PROM1,RAB30,RABIF,SLAMF1,SLC39A10,SLC47A1,Slco1a4,Slfn2,SOCS1,SOCS3,ST8SIA4,STAR,STAT5B,SUSD4,SYBU,TBXAS1,TLR2,TMEM176A,TMEM176B,TMEM45B,TNFRSF25,TNFRSF4,TNNC1,TNNI1,TNNT1,TOX,TRIM47,UBA7,UBE2L6,VWF,YBX2,ZFP36 | 1572 (24) |
| PDGF-DD | NA | complex | NA | -1.39e+00 | NA | 0.0e+00 | Casp12,CASP3,CASP8,Ccl2,Ccl7,EGR3,FGF2,KDR,PDGFRA,PEA15,Pmaip1,TUBB6,UNC5C | 916 (7) |
| MED14 | -1.70e-01 | transcription regulator | NA | -1.39e+00 | bias | 1.0e-02 | CD36,DUSP1,FOXP3,IRF8,ISG15,LAD1 | 899 (7) |
| FUS | NA | transcription regulator | NA | -1.39e+00 | NA | 1.0e-02 | ATF3,CCND1,CSMD1,FIS1,FLNA,HIF1A,ICAM1,NDUFB9,NDUFV2,PLK1,RPL18,RPS15,RPS16,RPS3,SLC22A17,SLC25A15,SLC2A1 | NA |
| Ikb | NA | group | NA | -1.39e+00 | NA | 1.0e-02 | BCL2L1,CCND1,CFB,HHEX,ICAM1,MAT2A,NR4A1,PTGS2,UACA | NA |
| VEGFD | -9.50e-01 | growth factor | NA | -1.39e+00 | bias | 1.0e-02 | ADAM33,BDNF,CCND1,NR4A1,PTGS2,VEGFC | NA |
| allyl isothiocyanate | NA | chemical toxicant | NA | -1.39e+00 | NA | 2.0e-02 | BCL2L1,CLDN3,MMP2,NFE2L2,OCLN,PTGS2 | NA |
| cocaine | NA | chemical drug | NA | -1.39e+00 | NA | 0.0e+00 | ADORA2A,BDNF,BHLHE40,CAMK2A,Ccl2,CCR5,CNR1,CREB1,CTU2,Dclk1,DUSP1,DUSP5,DYNLL1,EGR1,EGR2,ENO2,FGF2,FHL2,FOXO1,FOXO3,GADD45A,GADD45B,GPSM1,GRIA2,HOMER1,ICAM1,IFIT1,INHBA,IRS2,KCNC1,Klf16,KLF5,LAMC2,MIDN,MX1,NAB2,NOS1,NR4A1,NR4A3,NTS,PDGFB,PER1,PVALB,SEC24A,SIAH2,SNCA,STAT1,THBS1,TIPARP,Tpm1,TUBB,UBASH3B | 1141 (21) |
| 2,4,5,2’,4’,5’-hexachlorobiphenyl | NA | chemical toxicant | NA | -1.39e+00 | NA | 2.0e-02 | ABCC3,ACSL3,ADRB2,AKAP12,Akr1b7,AOX1,ATP1B2,CAMKK1,CREM,EBF1,EXOC4,FGFR1,GADD45A,GADD45B,GFRA1,MAD1L1,MAPK14,SLC1A4,SMAD7,SMOC1,SMPD3,SREBF1,TRA2A,TWF2,UGDH,WEE1,WNK2 | NA |
| Pro-inflammatory Cytokine | NA | group | NA | -1.39e+00 | NA | 1.0e-02 | CD47,CXCL13,F3,FGF2,GCLC,GLUL,ICAM1,ITGA1,LGALS1,LIPG,NFE2L2,NR4A1,OLR1,SDC4,SELE,SELP,SOCS3,TIMP1,TLR2,VCAM1 | 994 (19) |
| tert-butyl hydroperoxide | NA | chemical toxicant | NA | -1.40e+00 | NA | 2.0e-02 | BCL2L1,BTK,CASP3,COL2A1,FN1,Pmaip1,PTGS2,TGFB1 | NA |
| trichostatin A | NA | chemical drug | NA | -1.40e+00 | NA | 0.0e+00 | ABCA1,ABCC3,ABCC4,ABCC5,ABHD5,ACOT7,ACOT8,ADAMTS1,ADAMTS5,ADGRE1,ADH7,AHR,AKAP12,ALDH1A1,ANKRD1,ARG1,ARL6IP1,B2M,B3GNT2,BAIAP2,BCAT1,BCL11A,BCL2A1,BCL2L1,BCL2L11,BDNF,BLVRB,BMP4,BMP5,BRCA2,BTG1,C1QTNF6,C8orf44-SGK3/SGK3,CA12,CA9,CASP3,Ccl2,CCNA2,CCND1,CCND2,CCR3,CD1D,CD28,CD34,CD36,CD44,CD86,CD9,CDH1,CDH2,CDK5R1,CDK6,CDKN1A,CGREF1,CIITA,CISH,CLDN1,CLEC3B,COL2A1,COL6A3,COLEC12,CPA3,CREB1,CREM,CSF3R,CUX1,CXADR,CXCL10,CXCL12,CXCR4,CYBB,CYP1B1,CYP4B1,DAPK3,DDR2,DDX6,DEK,DLC1,DNASE1L3,DNM1,DOK2,DUSP1,E2F5,E2F8,ELF1,ELF4,EPC1,EPHA3,EPHX1,EZR,F2R,F3,FBLN1,FEZ1,FGF2,FGFR1,FLRT3,FN1,FOXC1,FOXO1,FOXP3,FRZB,FTL,FUBP1,G6PD,GADD45A,GADD45G,GAP43,GCLC,GDF11,GINS3,GLI2,GLRX,GRIA2,HBA1/HBA2,HDAC9,HIF1A,HLA-DRA,HPSE,ICAM1,ID2,IDH1,IGFBP4,IGFBP5,IGFBP6,IGFBP7,IL10RA,IL17A,IL2RA,INPP5F,IPCEF1,IRF1,IRF4,IRF8,ITGA1,JUND,KDR,KIF5C,KIT,KLF4,KLF5,L1CAM,LAMA2,LAMA3,LEF1,LEPR,LGALS1,LIMA1,LMX1A,LOX,LTBP1,MAD1L1,MAF,MAP1LC3B,MAP1S,MAP2,MAT2A,MBNL1,MET,MGST1,MICALL2,MICB,mir-143,MME,MMP14,MMP2,MOB2,MRC1,MSI1,MSN,MTO1,MVK,MYCN,MYF6,MYH14,MYH3,MYH7,MYOF,NARF,NCAM1,NDUFC2,NEFL,NEK6,NFE2L2,NFKBIA,NOTCH2,NR0B2,NR4A2,NRP1,OGT,OLFM1,OSTN,OXTR,PENK,PGAM2,PKIB,PLA2G7,PLAGL1,PLCB1,PLK1,PLK2,PNPLA2,PON2,PPARG,PPARGC1B,PRDM1,PRDX1,PREX1,PRKCD,PTGS2,PTPN6,PTPN7,RARA,RCAN3,RECK,REL,RELN,RERG,RET,RIMS2,RND3,RNF5,ROCK1,RUNX2,RXRA,S100A10,SCAMP2,Scd2,SCNN1G,SDC1,SDC2,SELE,SEMA3A,SEMA3C,SERPINE1,SFRP1,SFRP4,SGK1,SIAH2,SIRT2,SIRT7,SLC2A1,SLC38A1,SLC7A1,SLC7A8,SLC9A3,SMO,SMYD2,SNRPN,SOCS1,SPHK1,SPN,SPP1,SREBF1,SRSF1,STAG1,STAR,STAT5B,STAT6,STEAP2,STMN1,STT3A,TAGLN,TFPI2,TGFB1,THBS1,TIMP1,TKT,TLR2,TLR4,TMEM164,TMPRSS2,TMSB10/TMSB4X,TNC,TNFAIP2,TNFRSF10A,TNFRSF11B,TNFRSF1B,TOP2A,TP63,TRADD,TSKU,TWIST2,TYMS,TYRO3,UBXN1,UGDH,UNC13A,UNC5C,USF2,UTRN,VCAM1,VCAN,VEGFC,VIM,VWF,WDR77,WNT5A,XPO1,ZFP64,ZFYVE27,ZNRF1,ZSWIM6 | 1470 (19) |
| C1QA | -7.50e-01 | other | NA | -1.40e+00 | NA | 0.0e+00 | C3,C3AR1,C5AR1,Ccl2,CD44,CXCL10,EGR1,F2R,F3,MAP2,S100A10,SERPINE1,SYP,TIMP1,TLR4,VIM | 1048 (12) |
| ADRB2 | -2.23e+00 | G-protein coupled receptor | NA | -1.40e+00 | NA | 1.0e-02 | ADIPOQ,ANGPT2,ATP1A1,ATP1B1,CD86,COL1A1,CYP1B1,GNAI3,GNAS,IL17A,MME,NRP1,PDGFB,RETN,SPP1,TNFRSF11B | NA |
| fluvastatin | NA | chemical drug | NA | -1.40e+00 | NA | 3.0e-02 | BCL2L1,CCND1,CD9,CDKN1A,CYBA,EDN1,GCH1,PLAT,PTGIS,PTGS2,SERPINE1,THBD | NA |
| irinotecan | NA | chemical drug | NA | -1.41e+00 | NA | 3.0e-02 | BCL2L1,CDH1,CXCL10,F3,SNAI1,SNAI2,SOCS3,TYMS,UBE3A | NA |
| calcitriol | NA | chemical drug | NA | -1.41e+00 | NA | 0.0e+00 | AAAS,ABCC3,ABLIM1,ACKR4,ACSL1,ADAM19,ADHFE1,AFAP1L2,AHR,AKAP12,ALOX5,ANGPT2,ANKRD2,ANXA2,ARG1,ARHGEF28,ARHGEF3,ATP10D,ATP2B4,BACH1,BATF,BCAT1,BCL2L1,BCL3,BUB1B,C15orf48,C3,CACNA1D,CALB1,CALCR,Ccl2,CCNA2,CCND1,CCND2,CD28,CD44,CDCA7L,CDH1,CDK5R1,CDKN1A,CEBPD,CELSR3,CISH,CKM,COL3A1,COQ9,CSF1,CSF1R,CTSK,CXCL10,CXCL12,CXCL16,CYBB,DACT2,DCTPP1,DDAH1,DLL1,DOK5,DUSP1,DUSP10,ECH1,ECT2,EDN1,EGR1,ELN,ENPEP,EPHB2,ERBB3,ERRFI1,ESPL1,ETV5,EZH2,F2RL1,F3,FAM107A,FBN1,FBN2,FBXL2,FEN1,FIS1,FN1,FNDC5,FOXO3,Foxp1,FOXP3,FTL,G6PD,GADD45A,GADD45G,GAPDH,GATA4,GLRX,GRK5,GSR,HIF1A,Hmgn2 (includes others),HSD17B4,HSPB7,ID2,IDH1,IER3,IFI44L,IGF1,IGFBP5,IKBKE,IL10RA,IL17A,IL1RN,IL2RA,IRF4,ISG15,ITGA4,ITGB7,KIF23,KLF4,KLF5,LBH,LGALS1,LPAR1,LPL,LRRC17,LSM3,LTBP1,MAF,MAL,MCM7,mir-133,mir-143,MRC1,MRPL41,MSI1,MX1,MYCN,MYF5,MYH8,MYO15A,MYOG,N4BP2,NCAM1,NDUFV2,NEDD9,NFATC3,NFKBIA,NFKBIB,NOD2,NOX1,NOX4,NRM,NTHL1,NUP93,OCLN,OLFML2A,OSTN,OXCT1,P3H2,PC,PDE4D,PDK4,PDP2,PHGDH,PLD1,PMEPA1,PNPT1,PPARD,PPARG,PRC1,PRDX5,PRKCB,PRKCD,PTGES,PTGFR,PTGS2,RAB32,RAB38,RARRES1,REL,RFX1,RGCC,RNF144A,RSAD2,RUNX1T1,RXRA,S1PR2,SERPINB9,SKP2,SLC16A1,SLC25A6,SLC37A2,SLC45A3,SLC9A1,SMAD7,SMC2,SOAT1,SOCS3,SPP1,SREBF1,STAT6,STMN1,TACC3,TAGLN2,TGFB1,THBD,THBS1,TIMM50,TINAGL1,TLR2,TLR4,TLR7,TLR8,TMEM160,TNFRSF11B,TP63,TRPC6,TSHR,TSHZ3,TSKU,UMPS,VTCN1,WEE1,WNT11,WSB1,XPO1,ZNF608 | 1895 (19) |
| PDX1 | NA | transcription regulator | NA | -1.41e+00 | NA | 0.0e+00 | ABCC8,ACTG1,ANXA2,ASNS,ATF3,ATP2A2,Ccl2,CCND1,CD44,CDO1,CKMT1A/CKMT1B,COL1A1,COL3A1,CREM,CSNK2B,CX3CL1,CXCR4,DAPK3,DLK1,DUSP5,DUSP6,ECH1,EDEM3,EGR1,EIF4EBP1,ERO1B,F3,FGF1,FGF2,FGFR1,GAP43,GCH1,GFAP,GNAS,HAP1,HK1,ID2,IDH1,IER3,IRS2,KCNJ11,KLF10,KLF6,MAFA,MAN1A1,MAOB,MAP2,Marcks,MDH1,MITF,Mt1,NDUFB9,NKX6-1,NR5A2,PC,PDIA4,PHGDH,Pmaip1,PPP1R1A,PTGER3,PTPRF,RHOBTB1,RSAD2,SLC2A1,SLIT3,SPP1,SSBP3,TRPC3,TRPC6,TSPAN8 | 1531 (19) |
| PRKCE | 6.70e-01 | kinase | NA | -1.41e+00 | NA | 0.0e+00 | ACTA2,AMIGO2,BCL2L1,BIRC3,CAV1,CCND1,CDH1,CDKN1A,CDON,CRP,EGR1,FCGR1A,IL2RA,IL2RB,IL2RG,IRF3,ITGA2B,KCNC4,PRKCE,PRKD1,PTGER3,PTGS2,RGS2,STAR,SYP,VCAM1 | 1130 (16) |
| ST1926 | NA | chemical drug | NA | -1.41e+00 | bias | 3.0e-02 | ARF1,CDKN1A,CFL1,CLIC1,CNTN2,DAPK3,DYNLL1,EIF3G,FKBP5,GNAS,HIC1,HSP90AA1,IMP3,ITGA11,LGALS1,LSM3,MGST1,MOB1A,NDUFB9,PFN1,PSMA4,PSMB1,RPL6,RPS10,RPS15,RPS2,SLC25A6,SLIRP,SP140,SRSF3,SSBP1,TMEM14C,TMSB10/TMSB4X,TOMM7,UBE2M,UBL5,UGCG | NA |
| FSHB | NA | other | NA | -1.41e+00 | NA | 3.0e-02 | CCND2,INHA,INHBA,INHBB,ITGB3,KITLG,PLAT,SGK1 | NA |
| CALR | 1.70e-01 | transcription regulator | NA | -1.41e+00 | NA | 0.0e+00 | ATP2A2,B4GALT1,Calm1 (includes others),CASQ2,Ccl2,CDH2,CDKN1A,COL1A1,COL3A1,FN1,GJA5,GJC1,ICAM1,IL17A,LPL,MYL2,PTGS2,SCNN1G,SREBF1,TGFB1 | 1199 (22) |
| ZC3H14 | -7.00e-02 | other | NA | -1.41e+00 | bias | 0.0e+00 | BATF,CITED2,FGL2,IL15RA,NMI,PLAT,RBL1,RILPL1 | NA |
| PFKFB3 | 1.52e+00 | kinase | NA | -1.41e+00 | NA | 1.0e-02 | ADIPOQ,CXCL12,FGF2,ICAM1,PDGFB,RETN,TGFB1,VCAM1 | 1550 (18) |
| ursolic acid | NA | chemical drug | NA | -1.42e+00 | NA | 0.0e+00 | ATF3,BCL2L1,CASP3,CCND1,CDKN1A,CNP,CXCR4,EIF3C,EIF4EBP1,FGF2,IGF1,IL17A,MAG,MAL,MKI67,MMP2,MOG,OLR1,PLP1,PPARG,PTGS2,SLC38A2,SLC6A9,TLR4,TUBB4A,VCAM1 | 1138 (17) |
| NDP | NA | growth factor | NA | -1.42e+00 | NA | 1.0e-02 | ANGPT2,BDNF,FGF2,Mt1,PSIP1,SERPINF1 | NA |
| ciprofloxacin | NA | chemical drug | NA | -1.42e+00 | NA | 0.0e+00 | ABCC4,ACO2,ACSL5,ADGRE1,ATP6V1A,ATP6V1E1,BMP4,CCR1,CD47,CD86,CD93,COLEC12,CSF2RB,EDIL3,EMILIN2,HLA-A,ICAM1,ITGA9,ITGAL,ITM2C,MAN2B2,MMP2,MSR1,MYOF,NRCAM,NRP1,PTGS2,RBM28,RPS18,SIGIRR,SPP1,SPRED1,TLR7,UBTD1,VIM | 1159 (11) |
| ENO1 | 4.70e-01 | enzyme | NA | -1.42e+00 | NA | 0.0e+00 | BCL2L1,CDH1,CDH2,PTGS2,SELE,SNAI2,VIM | 1332 (17) |
| SREBF1 | 8.40e-01 | transcription regulator | NA | -1.42e+00 | NA | 0.0e+00 | AACS,ABCA1,ACADS,ACSL1,ACSL5,ADH1C,ADIPOQ,AK4,ALDOA,ALOX12,ANKRD2,ATOX1,BCL2L1,BEST1,BHLHE40,C5AR1,CAMK1D,CDKN1A,CEBPD,CFI,CHMP2A,COX4I1,CSRP1,CXADR,CXCL10,CYP4F2,CYP7B1,DHCR7,DLK1,DPY19L3,ELOVL5,ELOVL7,ETHE1,FADS1,FADS2,FBXO32,FN1,FOXO1,G6PD,GPAM,GPNMB,GPX3,GSR,HSPA1A/HSPA1B,IDH1,IRS2,KCNA2,KCNJ11,LPIN1,LPL,LSS,MDK,mir-133,MSMO1,MVD,MVK,MYL1,MYOD1,MYOG,NCF2,NFIL3,NKX6-1,NR0B2,PICK1,PIK3R3,PLEKHA4,PLS3,PLTP,PMP22,PNPLA3,PPARG,PTGS2,RETN,RPS24,S100A13,Scd2,SELENOP,SERPINE1,SLC20A1,SORBS3,SREBF1,STAR,TGFB1,TNFRSF1B,TNNI1,TNNI2,TRIM63,UCP3 | 1494 (23) |
| MMP2 | -9.30e-01 | peptidase | NA | -1.43e+00 | NA | 0.0e+00 | ABCA1,ACO2,ACTA1,BCL2L1,Ccl2,Ccl6,CCND1,CD36,CD44,CDKN1A,COL18A1,COL3A1,CSF2RB,CX3CL1,CXCL12,FN1,IL1RN,IL2RG,ITGA3,OCLN,PDK2,PDK4,SOCS1,TGFB1 | 1518 (19) |
| DDB1 | 3.00e-01 | other | NA | -1.43e+00 | NA | 0.0e+00 | AXIN2,BTG2,CDH1,CDKN1A,CEBPD,DNAJB1,EGR1,EGR2,EGR3,FMOD,ID2,KLF5,NR4A1,PPARG,PYGO2,STAT1,TRIB1,ZFP36,ZNF281 | 613 (3) |
| DEK | -6.80e-01 | transcription regulator | NA | -1.43e+00 | NA | 3.0e-02 | BIRC3,Ccl2,CDKN1A,CSF3R,LEF1,NFKBIA | NA |
| ITGB8 | -1.15e+00 | other | NA | -1.43e+00 | NA | 4.0e-02 | CDKN1A,P2RY12,RAC2,TGFB1,TMEM119 | NA |
| paclitaxel | NA | chemical drug | NA | -1.43e+00 | NA | 0.0e+00 | ACKR3,ACTA2,ADGRE1,ANXA5,APLNR,ARHGEF2,ASIC2,ATF3,BCL2L1,BCL2L11,BHLHE40,BIRC3,BTG2,CACNB3,CAV1,CCND1,CD44,CD47,CD53,CD86,CDC42EP3,CDK18,CDK2,CDKN1A,CNP,CRP,CXCL10,CYP1B1,CYP4F2,DCHS1,DDAH1,DUSP10,DUSP5,DUSP6,DVL1,EEF1E1,EGR1,EMP1,ETV1,ETV5,FLNA,FLT3LG,FOXO1,FOXO3,G0S2,GAD1,GADD45B,GAMT,GFAP,GFPT2,GRAMD1B,HIF1A,HLA-A,HPSE,ICAM1,IER3,IKBKB,ITGA3,ITGA5,ITGA6,JUND,KLF4,LCP1,LCP2,MKI67,MYO7A,NAV3,NCS1,NFKBIA,OSMR,PGK1,PHGDH,PHLDA1,PLIN3,PRELP,PTGS2,PTPN12,RAC2,SCN1B,SNAI2,STMN1,TFPI2,TGFA,THBD,THBS1,TNFRSF10A,TOP3B,TSC22D4,TWIST1,UGCG,UHRF1,WNT4 | 1543 (17) |
| MMP1 | NA | peptidase | NA | -1.44e+00 | NA | 0.0e+00 | CDK2,CDKN1A,CXCL12,FN1,HIF1A,IGF1,KDR,MYOCD,MYOD1,NFKBIA,PLTP,PTGES,PTGS2,RUNX2,S100A4,SERPINE1,TAGLN,TEK,TGFB1 | 1015 (14) |
| CARM1 | 4.80e-01 | transcription regulator | NA | -1.44e+00 | NA | 0.0e+00 | C3,Ccl2,CDKN1A,CXCL10,DDIT4,EGR3,FTL,GADD45A,GCLC,HSP90AA1,ICAM1,IGFBP4,MTSS1,MYOG,PTGES | 1521 (24) |
| EBF2 | -1.42e+00 | transcription regulator | NA | -1.44e+00 | bias | 0.0e+00 | ADAMTS15,Cox8b,LGI1,LGI2,MEOX1,NTM,QPRT,SFRP4,SHISA3,THBS4 | NA |
| CASR | -5.90e-01 | G-protein coupled receptor | NA | -1.44e+00 | NA | 0.0e+00 | ANGPT2,ARHGEF3,BCL2L1,BUB1B,CCND1,CCND2,CD44,CDH1,CISH,CSF1,CXCL10,DCTPP1,EDN1,EGR1,EZH2,FEN1,GADD45A,GADD45G,GATA4,Hmgn2 (includes others),IER3,IGFBP5,IQGAP1,ISG15,ITGB7,KIF11,LBH,LGALS1,LPL,MAGI1,NDUFV2,NEDD9,PPARG,PRC1,PTGS2,RGCC,RNF144A,SOCS3,THBD,TLR2,TYMS,WSB1 | 1293 (17) |
| DEF6 | -2.50e-01 | other | NA | -1.45e+00 | NA | 0.0e+00 | CDH1,CDH2,FN1,IL17A,MMP2,PRDM1,SNAI1,SNAI2,VIM,ZEB2 | 1158 (19) |
| KAT2A | -3.50e-01 | enzyme | NA | -1.45e+00 | NA | 0.0e+00 | ACTN4,ADAMTS1,ADAMTS5,AKAP12,BCL11A,BCL11B,BCL2L1,CASP3,CCND1,CCND2,CCNE2,CDC25B,CSRP2,DIRAS1,E2F2,EDEM1,EFNA5,EMP1,EZH2,FBXO32,FGF1,GABARAPL1,GCLC,HNRNPU,HSP90AA1,LGR5,MITF,MYOM3,NUDC,PDLIM1,PIK3R1,PRKDC,PROM1,PTPRO,RAB3D,RANBP1,RCAN2,RELN,SHOX2,SKP2,SLC16A1,SLC1A5,SLITRK1,SRSF1,TNFRSF10A,TRIM63,XPO1 | 1455 (20) |
| PGF | 5.10e-01 | growth factor | NA | -1.45e+00 | NA | 3.0e-02 | ALOX5,ATF3,CASP1,CXCR4,DCN,E2F2,EDN1,EGR1,HIF1A,KIT,NRP2,SERPINE1 | NA |
| MST1R | -6.20e-01 | kinase | NA | -1.46e+00 | NA | 2.0e-02 | ACTA2,ARG1,CCND1,CDH1,CXCL13,DVL1,ICAM1,IL17A,ROS1,VIM | NA |
| KDM4A | 5.20e-01 | transcription regulator | NA | -1.46e+00 | NA | 0.0e+00 | CCND1,CDKN1A,CSF2RA,CXCL10,FHL1,KLF5,PIM3,POC1B,SKA1,TTYH1 | 806 (13) |
| morphine | NA | chemical drug | NA | -1.46e+00 | NA | 2.0e-02 | AIF1,AQP4,AXIN2,BDNF,CALB1,CASP3,CCND1,CCR5,CDKN1A,CNR1,CREB1,CYBB,ERBB3,FZD10,GFAP,GNAS,KCNA5,KCNJ9,MAPK3,NET1,NR4A1,NTRK2,P2rx7,PENK,PLAT,PTGES,PTGS2,RGS20,SLC1A1,SPARC,THBS1,THBS2,TLR2,TLR4,WNT9A | NA |
| PKM | 7.70e-01 | kinase | NA | -1.46e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ALDOA,BCL2L1,CCND1,CD36,CD86,CDH1,CDH2,EGR1,ENO2,ENO3,FBP2,GAPDH,GSR,HGF,HIF1A,LSS,MKI67,MMP2,PC,PDK4,PGAM2,PKM,SDC2,SLC2A1,SNAI2,VEGFC | 1374 (21) |
| TFCP2 | -2.30e-01 | transcription regulator | NA | -1.46e+00 | NA | 1.0e-02 | A2M,CFH,EGF,POLA1,SPP1,TGFA,TYMS | NA |
| H1-6 | NA | other | NA | -1.46e+00 | NA | 0.0e+00 | ABCG4,B2M,BCAR1,BCL3,CBFA2T3,CD36,CSTF1,CYTH1,DENND2D,FARP1,GLUL,GPM6A,HIRIP3,KIF21B,METTL22,MMP15,MRPL38,OGT,PCBP4,PHLDA1,PLA2G5,PRKCQ,RILPL1,SFTPB,TEX2,TMEM230,TMEM53,TRPM4,USF2,ZC3H4 | NA |
| H1f1 | NA | other | NA | -1.46e+00 | NA | 0.0e+00 | ABCG4,B2M,BCAR1,BCL3,CBFA2T3,CD36,CSTF1,CYTH1,DENND2D,FARP1,GLUL,GPM6A,HIRIP3,KIF21B,METTL22,MMP15,MRPL38,OGT,PCBP4,PHLDA1,PLA2G5,PRKCQ,RILPL1,SFTPB,TEX2,TMEM230,TMEM53,TRPM4,USF2,ZC3H4 | NA |
| GHRL | -4.00e-02 | growth factor | NA | -1.46e+00 | NA | 1.0e-02 | ABCG1,BDNF,CASP3,EDN1,FOXO1,GPAM,IL1R1,LPL,MYF5,MYF6,MYOD1,MYOG,PPARG,PRKAA1,PRKAA2,PTGS2,SOCS3,SPP1,SREBF1,STAR,UCP3 | 1413 (18) |
| S1PR4 | -2.20e-01 | G-protein coupled receptor | NA | -1.46e+00 | NA | 0.0e+00 | ACKR2,ACTG2,C1R,Ccl2,COL6A3,CSF2RB,F3,FAM124B,HTRA3,IFI16,LTBP2,MOXD1,MRGPRF,OCLN,OLFML2B,SELP,SERPING1,ZNF354B | 685 (9) |
| SQSTM1 | 5.10e-01 | transcription regulator | NA | -1.46e+00 | NA | 0.0e+00 | ARID5A,Ccl7,CITED2,CKAP4,CXCL10,EDN1,FGL2,GCLC,IL15RA,IRF1,ISG15,MAP1LC3A,MAP1LC3B,NFE2L2,NFKBIA,PLAT,PLK2,RGCC,RILPL1,RSAD2,UGDH | 839 (14) |
| FOSL1 | -6.10e-01 | transcription regulator | NA | -1.46e+00 | NA | 0.0e+00 | ANKRD1,AXL,BDNF,Ccl2,Ccl6,Ccl7,CCND1,CD44,EDN1,EGR1,EGR2,ELN,GCLC,ITGB4,MAP1B,MET,MMP2,NRP1,NTS,PRDM1,RUNX2,SEMA6D,SERPINE1,SNAI1,SNAI2,SPARC,THBD,THBS1 | 1130 (17) |
| PTGFR | -1.63e+00 | G-protein coupled receptor | NA | -1.46e+00 | NA | 1.0e-02 | ACTA1,G6PD,GCLC,GSR,NOX1,NR4A1,OXTR,PTGS2 | 1215 (18) |
| gentamicin | NA | chemical drug | NA | -1.47e+00 | NA | 0.0e+00 | ABCC3,ABI1,ACSL3,ACSM3,AGMO,AK1,ALCAM,ALDH1A1,APOD,ATF3,BACH1,BMP1,BMP4,BTG2,BTG3,Ccl2,CCND1,CD9,CDC34,CDO1,CHKA,CITED2,CPEB1,CPQ,CRYL1,CSF1,CSRP2,CXCL10,DIO1,DNAJB4,DPP4,EEF1A1,EGF,EGR1,EXTL3,Fn3k,GADD45A,GATM,GFER,GJB2,GPM6A,GUK1,HNRNPU,HSD17B4,HSP90AA1,HSPA1A/HSPA1B,ICAM1,IDH1,IGFBP5,IL10RA,IRF1,KHDRBS3,KLF6,LAMP2,LGALS1,LITAF,MAF,MCOLN1,MLKL,MMP2,MPST,MRPL23,MYO1G,NR1D2,NUAK1,NUDC,PC,PDIA4,PHGDH,PPP1R1A,PTN,PTPRZ1,Pzp,RGCC,RHOA,RIPK3,RTN4RL1,SART3,SLC1A1,SLC7A8,SLC9A3,SLCO4A1,SPP1,ST3GAL6,SUOX,SYNJ1,TGFB1,THY1,TIMP1,TMC7,Tpm3,TUBB,UGT8,VAT1,VCAM1,ZFP36L1 | 1038 (13) |
| FOS | -7.50e-01 | transcription regulator | NA | -1.47e+00 | NA | 0.0e+00 | A2M,ACTG1,ALDH1A3,ANKRD2,APLN,ARF1,ATF3,B4GALT1,BCL2L11,BCL9,BDNF,C3,C3AR1,CALU,CAMK2D,CASP3,Ccl7,CCNA2,CCND1,CD244,CD44,CDH1,CDH11,CDON,CELF2,CERS4,CHI3L1,COBLL1,COL16A1,COL18A1,COL1A1,COL8A2,CTSH,CXCL10,CXCL16,DAP,E2F7,EDN1,EGR1,EGR2,EMB,ENAH,ERCC1,ESM1,EZR,F3,FBLIM1,FBN1,FGF2,FLRT2,FMN1,FN1,FOLR2,FOXC1,FOXO3,FRZB,FSTL1,FZD5,FZD6,GAS2,GATA4,GM2A,GPSM2,GSR,HAS2,HBA1/HBA2,HOOK1,ICAM1,IFI16,IGFBP5,IGFBP6,IL1RL1,IRAK3,IRS2,ITGA2,ITGA6,ITGB4,KITLG,KLF6,LAMA3,LAMP2,Ldha/RGD1562690,LOX,LPL,LTBP1,LTBP2,LYPD6,MET,MGST1,MMP2,MMRN1,MPZL2,MSLN,MYH6,NCF2,NDUFS7,NET1,NFE2L2,NFIL3,NOTCH4,NR4A1,NR5A2,NTS,NUBP1,OXTR,PCDH11X,PCNX1,PDPN,PENK,PFN1,PGAM2,PHLDA1,PKIB,PKN1,PLAGL1,PLAT,PLD1,PLK2,Pmaip1,PMEPA1,PRDM1,PRDX1,PRKCE,PRPF4B,PTCHD1,PTGS2,PTP4A2,PTPN12,PTPRD,PTPRO,PTPRZ1,RAB31,RAP1GAP,RARA,RARG,RBBP4,RFNG,RGMA,RGS4,RPS18,RPS24,RUNX1,RXRA,S100A10,SDC1,SELENBP1,SEMA3A,SEMA3B,SEMA3E,SEMA6D,SERPINB9,SERPINE1,SFRP2,SFRP4,SIRPA,SMAD7,SNAI1,SNAI2,SNX3,SOCS3,SPHK1,SPP1,STAR,STAT6,STK3,STMN1,STX11,SULF2,SUMO2,SWAP70,TAL1,TBCA,TGFB1,TGFBI,TIMP1,TIPARP,TNFRSF11B,TNMD,Tpm1,Trib2,TUBB,UGCG,UTRN,VAV3,VCAM1,VEGFC,VEGFD,VIM,WEE1,WNT10B,WNT11,WNT4,WNT5A,WNT6,XYLT1 | 1532 (19) |
| ACVR1 | -9.80e-01 | kinase | NA | -1.48e+00 | NA | 0.0e+00 | AMHR2,AUTS2,C1R,CDKN1A,CSRP2,DCN,EDIL3,FSTL1,ICAM1,ID2,IL33,LEF1,MOSPD2,NTN1,OGN,PROS1,PTX3,RNF157,SELE,SRPX2,SUSD5,VCAM1 | 1093 (19) |
| calcimycin | NA | chemical reagent | NA | -1.48e+00 | NA | 0.0e+00 | AMD1,ATF3,ATP2A2,BCL2L11,CD83,CD86,DDIT4,DNAJC12,EGR1,EIF6,ELN,FGF2,FN1,GCH1,HERPUD1,HIF1A,ICAM1,IGF1,IL1RL1,INHBA,IRF4,MSR1,MYF5,MYH2,NR4A1,PON2,PPARG,PTGS2,SERPINE1,SLC2A1,STAR,TLR2,TLR4,TPO | 856 (13) |
| NFIC | 1.40e-01 | transcription regulator | NA | -1.48e+00 | NA | 1.0e-02 | ALDOA,CCND1,CDKN1A,CSF1,GFAP,LEF1,PDGFRA,TGFB1,TNFSF18,TPO,WNT5A | NA |
| PG3-Oc | NA | chemical reagent | NA | -1.49e+00 | bias | 0.0e+00 | ACER2,ATF3,CDKN1A,DRAM1,JAG1,JUND,MET,PGPEP1,PRDM1,ROCK1,SLC2A1,TNFRSF10A | 1126 (7) |
| PTGS1 | -4.70e-01 | enzyme | NA | -1.49e+00 | NA | 0.0e+00 | ANGPT2,ARG1,ATF3,Ccl2,CYBB,EDN1,FGF2,MMP2,MYOZ1,NCF1,OXTR,PLA2G4A,PTGER3,PTGES,PTGS2,TNNI2,YWHAQ | 1272 (18) |
| GSK0660 | NA | chemical reagent | NA | -1.50e+00 | NA | 0.0e+00 | FBXO32,FN1,PDK4,THBS1,TRIM63 | 1008 (13) |
| ST6GALNAC1 | NA | enzyme | NA | -1.50e+00 | NA | 0.0e+00 | B2M,CDH1,CDH2,SNAI1,SNAI2,VIM | NA |
| NFYA | -1.01e+00 | transcription regulator | NA | -1.50e+00 | NA | 1.0e-02 | CCNA2,CDC25B,CDKN1A,COL11A1,EGR1,EPHX1,GADD45A,GADD45B,GPAM,HLA-DRA,ICAM1,IGF1,IRF1,JUND,LPIN1,NPR1,PGK1,PKM,POLA1,RGS4,Scd2,TOP2A,VWF | NA |
| TWIST2 | -2.03e+00 | transcription regulator | NA | -1.51e+00 | NA | 0.0e+00 | BCL11A,BIN1,CCND1,CD44,CD7,CDH1,CDH2,CDKN1A,CKM,DUSP5,DUSP6,FBLN5,FN1,KLF6,MAF,MYCN,PRKAA1,PRKAA2,RNF43,SNAI1,SNAI2,TGFB1,TWIST1,VIM,ZEB2 | 1237 (18) |
| IOX2 | NA | chemical reagent | NA | -1.51e+00 | bias | 0.0e+00 | AK4,CA9,CARD11,EGLN1,ENO2,HIF1A,KDM3A,LOX,LOXL2,PLOD2,SLC2A1 | NA |
| VH032 | NA | chemical reagent | NA | -1.51e+00 | bias | 0.0e+00 | AK4,CA9,CARD11,EGLN1,ENO2,HIF1A,KDM3A,LOX,LOXL2,PLOD2,SLC2A1 | NA |
| STAT5a/b | NA | group | NA | -1.51e+00 | NA | 0.0e+00 | AHR,ARG1,BCL2A1,BCL2L1,BCL2L11,BCL6,CCND1,CCND2,CD36,CDC42EP5,CDKN1A,CDKN2C,CISH,DUSP1,EBF1,EMP1,EPHA4,ERFE,F2R,FCER1G,FCGR1A,FCMR,FOXP3,GZMB,ID2,IGF1,IGFALS,IL17A,IL2RA,IRF1,ITGA2B,LCP2,LEPR,MAF,PDGFB,PRDM1,PROX1,PTGER3,PTGS2,RARA,SOCS1,SOCS3,TLR2,TNNI1,VWF | 1283 (15) |
| WWTR1-CAMTA1 | NA | fusion gene/product | NA | -1.51e+00 | bias | 1.0e-02 | ATF3,CEBPD,CRYAB,MMP2,S100A6,SERPINE1,SOX7,TOP2A | NA |
| HOXA11 | 1.50e-01 | transcription regulator | NA | -1.51e+00 | NA | 2.0e-02 | ANXA1,CD47,COL1A1,ITGA8,NRCAM,RUNX2,SIX2,SPP1 | NA |
| GSKJ4 | NA | chemical reagent | NA | -1.51e+00 | NA | 1.0e-02 | ARHGDIB,CD83,CD86,CHCHD5,CXCL10,D2HGDH,FXN,G6PD,GADD45GIP1,IL17A,MRPL21,MRPL53,MRPS12,NDUFA7,NDUFAF2,PFKFB3,SLC2A9,SLC45A3,TIMM13,TIMM50,UCP3,UQCR11 | NA |
| EPO | NA | cytokine | NA | -1.51e+00 | NA | 0.0e+00 | ADAMTS10,ANGPT2,ANK1,ARG1,B2M,BCL2L1,BCL2L11,BCL3,BCL6,BDNF,BLVRB,BMP4,BTG1,CASP3,CCND2,CD36,CD86,CDKN1A,CISH,CKM,CLIC1,CTSK,CXCL12,CXCR4,DALRD3,DCTN6,EDN1,EDN3,EEF1A1,EGR1,ERFE,FABP1,FBXL18,FGF2,FXN,GAPDH,GATA4,GLUL,HBA1/HBA2,HMGN1,ID2,IL1RL1,ITGA4,KIT,L3MBTL1,LCP1,MAN2A1,MME,MMP2,MRC1,MYF5,MYL1,MYOD1,MYOG,N4BP2L1,NAB2,NFKBIA,NMNAT1,Podxl,PRKCB,PRKCD,PRKCQ,PRKCZ,PTGS2,PTPRB,RHOA,RNF128,ROCK1,SAMSN1,SELE,SELP,SKP2,SMAD7,SOCS1,SOCS3,SPP1,SYP,TAL1,TLR4,TNFRSF11B,TPH1,UGCG,VEGFC,VWF | 1177 (18) |
| prexasertib | NA | chemical drug | NA | -1.51e+00 | bias | 0.0e+00 | ATF3,BCL3,BCL6,BIRC3,BTG2,C3,CDKN1A,CSRNP1,DUSP1,EGR1,EGR3,GADD45B,ICAM1,IER3,IFIH1,KLF4,NFKBIA,NR4A3,PHLDA1,PLK2,PTGS2,SERPINE1,SFRP4,SGK1,SLIT3,SNAI1,TRIM69,ZFP36 | 1500 (20) |
| USP7 | 3.10e-01 | peptidase | NA | -1.51e+00 | NA | 2.0e-02 | ACKR3,CCND2,CD36,CDKN1A,CKMT1A/CKMT1B,COL5A1,FABP1,FKBP5,FLNA,FOXP3,HLTF,ISG15,ITGB7,KAT5,KDM2B,PPARG,TNNT2 | NA |
| MSI2 | 8.60e-01 | other | NA | -1.51e+00 | NA | 5.0e-02 | CDH1,CDH2,CDKN1A,CLDN3,FN1,SNAI1,VIM | NA |
| CD28 | -1.75e+00 | transmembrane receptor | NA | -1.52e+00 | NA | 0.0e+00 | AHR,ANXA1,AP1B1,ARHGDIB,BCL2A1,BCL2L1,BHLHE40,BIN1,BTG1,C2,CAMK2A,CASP3,CASP8,CCND1,CCND2,CCR5,CD226,CD28,CD86,CDK2,CDK6,CENPF,CISH,CLK1,CRB1,CREM,CXCL13,CXCR4,DAD1,EGR2,FCER1G,FOXP3,FYN,GAPDH,GBP2,GLI1,GZMB,H2AC18/H2AC19,HAX1,HCCS,HINT1,HIVEP3,HMGN1,HOMER2,HSPA1A/HSPA1B,IFRD2,IGFBP5,IGFBP6,IL10RA,IL10RB,IL15RA,IL17A,IL18R1,IL1R1,IL2RA,IL4I1,IL7,IRF1,IRF4,IRF8,ITGA4,ITGAL,ITGB7,KDELR2,LCP1,LTBP1,MAF,MAP3K10,MMP2,MMRN1,MSLN,MSR1,NDFIP2,NFKBIA,NLGN3,NOS1,NR4A1,OAZ1,PDE4A,PDE4D,PRDM1,PRDX4,PSMA6,PTGS2,PTPRJ,RAB2A,REL,RGCC,RNF128,RPL6,SLC16A3,SLC7A1,SOCS1,SOCS3,STAT6,STEAP2,TFPI2,THBS1,TNFRSF1B,TNFSF18 | 953 (16) |
| AIF1 | -8.00e-01 | other | NA | -1.52e+00 | bias | 2.0e-02 | ACTA2,CCND1,COL1A1,COL3A1,IL17A,TGFB1 | NA |
| NR3C2 | -2.40e-01 | ligand-dependent nuclear receptor | NA | -1.52e+00 | NA | 0.0e+00 | ADAMTS1,AQP4,ARG1,ATP1B1,BCL2A1,BCL2L1,BMP4,Ccl2,CCR5,CNN3,COL1A1,COL3A1,CXCR4,CYP1B1,DDIT4,ECHDC2,EDN1,EGR1,Fcrls,FGF2,FKBP5,FN1,GPX3,Gsta4,ICAM1,IGF1,INHBA,KDR,KLF9,LYST,MAP2,MSRB1,NOX4,NR4A2,PLAT,PLIN4,PPIB,PRDX4,PTGS2,PTX3,RAPGEF4,RGS2,RRAD,SEMA3C,SERPINE1,SGK1,SLC9A1,SPHK1,TACC2,TGFB1,TGFBI,VCAM1 | 1512 (18) |
| EPHB1 | -7.90e-01 | kinase | NA | -1.52e+00 | NA | 2.0e-02 | Ccl2,EGR1,EGR2,PTGS2,SERPINE1 | NA |
| putrescine | NA | chemical - endogenous mammalian | NA | -1.52e+00 | NA | 0.0e+00 | CCNE2,CDK2,CDK5R1,CDKN1A,MAT2A,OAZ1,TLR2 | NA |
| FGF18 | -7.20e-01 | growth factor | NA | -1.52e+00 | NA | 3.0e-02 | BAMBI,CDH1,CSF1,RUNX2,SNAI1,TIMP1 | NA |
| HNRNPAB | NA | enzyme | NA | -1.53e+00 | NA | 0.0e+00 | ACTA2,CDH1,CDK2,PTGS2,S100A4,SNAI1,SPP1,TWIST1,UHRF1,VIM | 1093 (12) |
| MYF6 | 7.40e-01 | transcription regulator | NA | -1.53e+00 | NA | 0.0e+00 | APLN,BDNF,Ccl2,CCL24,CDKN1A,CKM,CTSH,CX3CL1,CXCL10,CXCL13,DCN,DLL1,DPP4,EGF,ERFE,FGF2,FGF9,FNDC5,FSTL1,GDF11,IGF1,IL16,IL17A,IL1RN,IL33,IL7,INHBA,METRNL,MMP2,MSTN,MYF6,MYOD1,MYOG,OSTN,PDGFB,RECK,SCN4A,SERPINE1,SERPINF1,SPARC,SPP1,TGFB1,THBS1,TNFRSF10A,TNFRSF11B,TNFRSF8,TPO,VEGFC | 505 (7) |
| ZNF507 | 4.60e-01 | transcription regulator | NA | -1.53e+00 | NA | 0.0e+00 | BCL2L1,CASP3,CCND1,CDH1,CDH2,CDK2,CDK6,SNAI1,SNAI2,TWIST1,VIM,ZEB2 | 1119 (16) |
| LOX | -1.88e+00 | enzyme | NA | -1.53e+00 | NA | 3.0e-02 | CDH1,COL3A1,ELN,PDGFRA,SNAI1,SNAI2,TEK,TP63 | NA |
| nitroarginine | NA | chemical reagent | NA | -1.54e+00 | NA | 0.0e+00 | ALOX12,Casp12,CD44,CD53,CKM,EGR1,GCLC,HTR2B,JUND,NCAM1,NFIL3,PLAT,RHOA,SPP1,TGFB1 | 1477 (18) |
| ammonium chloride | NA | chemical drug | NA | -1.54e+00 | NA | 2.0e-02 | AQP4,ATP1A1,CD9,EDN1,EDN3,FOXO1,MET,PKD2,SNCA | NA |
| IL10 | NA | cytokine | NA | -1.54e+00 | NA | 0.0e+00 | ABCA1,ACTA2,ARAP2,ARG1,ARNT2,ATRX,BCL2A1,BCL2L1,BCL2L11,BCL3,BRCA2,BUB1B,CA12,CASP3,CASP8,Ccl2,Ccl6,Ccl7,CCND2,CCR1,CCR5,CD28,CD36,CD44,CD74,CD83,CD86,CDK6,CDKN1A,CEACAM1,CENPF,CIITA,CIT,COL1A1,CSF1,CSF1R,CSF2RB,CSF3R,CTSC,CTSE,CTSH,CTSS,CX3CR1,CXCL10,CXCL12,CXCL13,CXCL16,CXCR4,DCN,DUSP1,E2F2,E2F8,ELAVL1,ESPL1,F3,FAAH,FCER1G,FCGR1A,FCGR2B,FCGR3A/FCGR3B,Fcrls,FKBP5,FLRT2,FOXP3,GZMB,HCK,HDAC9,HGF,HIF1A,ICAM1,IGFBP4,IKBKB,IL10RA,IL17A,IL17RA,IL18R1,IL1R1,IL1RN,IL2RG,IL33,IL7,INHBA,INPP5D,IRF1,ITGA4,ITGAE,ITGAL,ITGB7,KITLG,LAMP2,LGALS1,LY75,LYN,LZTS1,MAF,MAN1A1,MAN2A1,MKI67,MMP14,MMP2,MRC1,MS4A2,MSR1,MYOG,NEDD9,NOD2,NOTCH2,NR4A3,PAM,PHGDH,PIK3CG,PLA2G2A,PLEK,PLK1,PRDM1,PTAFR,PTGS2,PTX3,RAB7A,RARRES1,S100B,SELE,SLAMF1,SLC1A3,SOCS1,SOCS3,SPP1,STAT1,STX11,TGFB1,TIMP1,TINAGL1,TLR2,TLR4,TLR5,TLR7,TLR8,TNFRSF1B,TOP2A,TWIST1,TWIST2,VCAM1,VCAN,VTCN1,WEE1,ZFP36 | 1274 (17) |
| Mapk | NA | group | NA | -1.54e+00 | NA | 0.0e+00 | APLN,BCL2L1,BDNF,CCND1,CDKN1A,COL1A1,CYBB,DBP,EGR1,F3,GZMB,HGF,IGF1,IL17A,IRAK3,IRS1,ITGA4,ITGB7,NOS1,NOX1,NR4A3,Peg3,PER1,PPARD,PRKCZ,PTGS2,RUNX2,S100A10,SNAI1,SNAI2,SPP1,STAT1,VCAM1 | 1122 (14) |
| CNR1 | -7.60e-01 | G-protein coupled receptor | NA | -1.55e+00 | NA | 0.0e+00 | ADIPOQ,APCDD1,BCL11B,BDNF,BMP15,BMP4,CA9,Ccl2,CEACAM1,CNR1,COX4I1,CXCL10,CYP27A1,CYP7B1,DLL1,EGF,ERRFI1,FGF10,FGF2,GAD1,GLO1,HEY2,IGF1,KIF11,MDK,MSTN,NDN,NOD2,NTN1,PAX3,PDGFRA,PENK,PLD1,PTGS2,RGMA,RXRG,S100A6,S100B,SIX1,SLC22A17,SLC35B2,SOX6,SREBF1,TGFB1,TIMP1,VEGFC,WNT6 | 1391 (18) |
| iron | NA | chemical - endogenous mammalian | NA | -1.55e+00 | NA | 3.0e-02 | CCND1,CCND2,CDKN1A,CSNK2B,CYBRD1,FTL,GADD45A,GADD45B,GADD45G,HIF1A,MCOLN1,Mt1,NFYA,SLC39A8,SNCA | NA |
| 3,4,5,3’,4’-pentachlorobiphenyl | NA | chemical toxicant | NA | -1.55e+00 | NA | 0.0e+00 | BDNF,BMP4,CA3,CACNA1D,CALB1,CCND2,CD44,COL1A1,Cox8b,CYP1B1,DACT2,EGF,EPB41L3,FGF9,FOXO1,GADD45A,GRHPR,Gsta4,HSPA1A/HSPA1B,HSPA2,IDH1,NR0B2,NR2F1,PRKAR2B,PTGFR,Slco1a4,SLCO2B1,SLCO3A1,TIPARP,TMSB10/TMSB4X,TNC | 1634 (22) |
| TNFSF13B | -7.90e-01 | cytokine | NA | -1.56e+00 | NA | 0.0e+00 | ADGRG3,ADIPOQ,ADORA2A,ALOX15,APLN,BCAR1,BCL2A1,BCL2L1,BCL2L11,BCL6,C2,CCND2,CCR1,CD200,CD74,CD83,CD86,CLEC4M,CTSS,CXCR5,DAB2IP,DDR2,DUSP5,ECT2,EFNA5,F3,FCGR2B,FGR,FOXO1,GCNT2,GPR183,HCAR2,HLA-DQA1,ICAM1,IL1RN,IL2RG,INHBA,ITGA1,MAP3K14,NR4A2,PLEK,PLK1,PRDM1,PRDM16,S100B,SMO,SNCA,SPP1,THBS1,TNFAIP6,TNFRSF8,UACA,UNC5C | 1231 (14) |
| GLI3 | -3.60e-01 | transcription regulator | NA | -1.56e+00 | NA | 0.0e+00 | ACTA2,BMP4,CCND1,CCND2,COL1A1,DLL1,DUSP1,DUSP5,EBF1,EGR1,EMX2,FGF10,FOXC2,FOXO1,GLI1,GLI2,GREM1,IRF1,MYCN,OSR1,PTCH1,RUNX1,RUNX2,SFRP1,STMN1,TAL1,TCF15,TNFRSF10A,WNT2B,WNT5A | 461 (7) |
| SCUBE3 | -1.51e+00 | other | NA | -1.56e+00 | bias | 0.0e+00 | MMP2,SERPINE1,SNAI1,SNAI2,TGFB1,VIM | 678 (9) |
| quinolinic acid | NA | chemical - endogenous mammalian | NA | -1.57e+00 | NA | 5.0e-02 | BCL2L1,BDNF,EGR1,FOXP3,GAD1,GFAP,GFRA1,HSPA1A/HSPA1B,JUND,NTRK2,PENK,PTGS2,RET | NA |
| dimethylnitrosamine | NA | chemical toxicant | NA | -1.57e+00 | NA | 0.0e+00 | ACTA2,BMP3,Calm1 (includes others),CDH1,CDKN1A,COL1A1,COL3A1,CRP,ICAM1,IGFBP5,MAPK3,Mt1,NFE2L2,NR4A1,PRKCZ,TGFB1,TIMP1,VIM | 1550 (19) |
| SNHG20 | NA | other | NA | -1.57e+00 | NA | 0.0e+00 | CCND1,CDH1,CDH2,CDKN1A,VIM,ZEB2 | NA |
| 2,3 butanedione monoxime | NA | chemical drug | NA | -1.57e+00 | NA | 2.0e-02 | ACTA1,ATP1A1,ATP2A2,ATP2B4,MYH7,MYOD1,MYOG,SCN5A | NA |
| tetrachlorodibenzodioxin | NA | chemical toxicant | NA | -1.57e+00 | NA | 0.0e+00 | ABHD5,ACER2,ACOT7,ACSL3,ACTA2,ADCY4,ADH7,ADHFE1,AHR,AHRR,AIF1,ALCAM,ALDH1A3,ALOX5,ARL6IP1,ARNT2,ASNS,AVEN,B4GALT1,BCAT1,BDNF,BMP4,BTG1,CA3,CACNA1D,CALB1,CASP1,CCL21,CCNA2,CCND1,CCNE2,CD36,CD86,CD9,CDC25B,CDH1,CDK2,CDKN1A,CHD7,CMA1,COL13A1,COL18A1,Cox8b,CRYAB,CYP1B1,CYP2S1,CYP4B1,DACT2,DCLK3,DUSP6,E2F8,EBF1,EDN1,EGF,ELN,EMP3,ENC1,ENPEP,ERBB3,ESRRG,F3,F5,FGF9,FMO2,GAD1,GADD45B,GHITM,GLI2,GLRX,GNG11,GPI,GRHPR,HDAC4,HDAC7,HDAC9,HOXD10,HRAS,HSPA1A/HSPA1B,HSPA2,IDH1,IL10RA,IL17A,IL1R1,IL2RA,IRF1,IRS1,IRX5,ITGA5,ITGAL,ITGB7,JAG1,JUND,KCNA5,KHDRBS1,KRT19,LPAR1,LYST,MMP14,MMP15,MYH6,MYO10,NAT2,NCF4,NEDD9,NFE2L2,NMT2,NR0B2,NRG4,NTHL1,PCDH18,Pcp4l1,PLAGL1,PMM1,PPAN,PRDM1,PRKAR2B,PRKCB,PTGFR,PTGS2,RXRA,RYR1,S100A4,SDC1,SEMA3C,SERPINE1,SERPINH1,SESN1,SH3BGRL2,SHOX2,SIM1,SLC12A7,SLC2A1,SLC38A3,Slco1a4,SLCO2B1,SLCO3A1,SPP1,STAR,STMN1,TGFA,THBS1,TIPARP,TNC,TNFRSF19,TNFSF8,TNNT1,TUBA8,TYMS,UGDH,UGT1A4,VEGFC,VEGFD,ZFP57 | 1343 (16) |
| MEDAG | -1.40e+00 | other | NA | -1.57e+00 | NA | 0.0e+00 | CD36,CDH1,CDH2,LPL,PLIN1,PPARG,SNAI1 | 888 (7) |
| crizotinib | NA | chemical drug | NA | -1.58e+00 | NA | 0.0e+00 | BCL2L1,BCL2L11,CDH1,COL3A1,COL5A2,COX4I1,ERBB3,MITF,OCLN,OSMR,ROS1,SERPINE1,SNAI1,SPARC,VCAN,VIM,WIPF1 | 1206 (20) |
| APOC1 | NA | transporter | NA | -1.58e+00 | NA | 0.0e+00 | CASP3,CDH1,CDH2,FGF2,FSCN1,HSP90AA1,SNAI1,SNAI2,TIMP1 | 1755 (21) |
| MECP2 | 4.00e-01 | transcription regulator | NA | -1.58e+00 | NA | 0.0e+00 | ANK1,ANXA1,ARHGAP24,ARHGAP42,BCAT2,BDNF,CAMK1D,CAMK2A,CCDC141,CD86,CDH1,DOCK8,DPP4,DPYSL2,EFNA5,EGR1,EPHB6,EZH2,FKBP5,FOXP3,FRZB,GAD1,HBA1/HBA2,HOXD9,KCNA1,KCNF1,MRC1,Mt1,NACC2,NAV3,NR4A1,NXPH3,PLA2G4E,PLP1,PLS3,PROM1,PTGS2,RELN,RGS20,S100A4,SELENOK,SEMA3D,SGK1,SPN,SRPX2,TBC1D2B,TFPI2,TP53BP2,UBE3A,UNC5C,UNC5D,UTRN,VIM | 1461 (25) |
| PTHLH | NA | other | NA | -1.58e+00 | NA | 1.0e-02 | ADAMTS1,BCL2L1,Ccl2,CCND1,CDC25B,CDK2,CDKN1A,COL2A1,CTSK,ECM1,FN1,HSPA1A/HSPA1B,IGF1,ITGA6,LEF1,PTGS2,RGS2,RUNX1,RUNX2,SERPINE1,SMPD3,TNC,TNFRSF11B | 1135 (19) |
| Smad2/3-Smad4 | NA | complex | NA | -1.58e+00 | NA | 0.0e+00 | ACTA2,CDH1,CDH2,CDKN1A,COL1A1,GLI2,IGFBP5,JAG1,NOX4,SERPINE1,SMAD7,SNAI1,VIM | 1307 (23) |
| Collagen Alpha1 | NA | group | NA | -1.58e+00 | NA | 2.0e-02 | CDH2,CDKN1A,COL1A1,IL1RN,MMP2,PTGS2 | NA |
| TBX5 | -1.43e+00 | transcription regulator | NA | -1.59e+00 | NA | 0.0e+00 | ACTC1,ACTN2,ANKRD1,ATP2A2,CASQ2,CCBE1,Ccl6,COL1A1,COL3A1,CXCR4,ECM2,FAP,FGF10,GATA4,GJA5,HEY2,HSPB7,IFI16,IL7,KCNA5,MYH6,MYL2,NFATC4,PHKA1,PLA2G2A,PTGS2,PTPRB,S100A4,SCN5A,TNFSF8,TNNC1,TNNT2,VIM | 1394 (20) |
| Ca2+ | NA | chemical - endogenous mammalian | NA | -1.59e+00 | NA | 0.0e+00 | ABHD5,ACTA2,ADORA2A,AHR,ALDH1A3,ALOX12,ATF3,ATP2A2,BCL2L1,BDNF,CCND1,CCND2,CD83,CD86,CDH1,CDK2,CDKN1A,CEBPD,COL1A1,COL2A1,COMMD5,CPA3,CREM,CSRP1,CXCR4,CYP1B1,DBP,DNASE1L3,DUSP1,E2F2,E2F5,EDN1,EGR1,FAAH,FGF2,FN1,GRK5,HDC,HOMER1,ICAM1,IL1RL1,IL33,IRF1,IRS2,ITGA3,ITGA6,JUND,KLF4,MAG,MMP19,MSR1,MYH2,MYH7,MYL1,MYOCD,NFKBIA,NOS1,NR4A1,NR4A3,NR5A1,NTRK2,PEBP1,PER1,PER3,PLS3,PPARG,PRSS12,PTGS2,Rcan1,RNF152,RUNX2,SELP,SERPINE1,SGK1,SNAI2,SPP1,STAR,TAGLN,TEF,TGFB1,TLR4,TNFRSF11B,TRPC6,TSHR,UGCG,VCAM1,VEGFD | 1373 (15) |
| CD40 | -4.20e-01 | transmembrane receptor | NA | -1.59e+00 | NA | 0.0e+00 | ANPEP,ASNS,ATP6V1A,BCL2A1,BCL2L1,BCL2L11,BCL6,BIRC3,BYSL,Ccl2,CCNA2,CCND1,CCND2,CD22,CD44,CD83,CD86,CDK6,CDKN1A,COX6B1,CSF1,CX3CL1,CXCL10,CXCL12,CYSLTR1,DAPP1,DCTPP1,DUSP1,DUSP6,EDEM1,EXOSC5,F3,FCGR2B,FLT3LG,GAPDH,GPI,GRWD1,GZMB,HK1,HSPE1,ICAM1,IL10RA,IL15RA,IL1RN,IL2RA,IL2RB,IL4I1,IMP4,IRF1,IRF4,ITGAL,ITGB2,KLF4,KLF9,MAP3K14,MAP3K6,MET,MMP14,NDUFAB1,NDUFB3,NDUFB9,NFKBIA,NOP16,PES1,PLK4,PRDM1,PTGS2,RASGRF1,REL,RRP9,SAMSN1,SELE,SERPINE1,SLAMF1,SLC1A5,SLC2A1,SLC38A1,SLC38A2,SMAD7,TCOF1,THBD,TLR2,TNFRSF11B,TNFRSF25,TRAF5,VCAM1,ZBTB16 | 942 (12) |
| SKIL | -9.00e-02 | transcription regulator | NA | -1.59e+00 | NA | 0.0e+00 | ACTA2,CDH1,CDH11,CDKN1A,CXCL12,DCHS1,DIXDC1,MYOG,RHOBTB1,SERPINE1,SLC1A5,SLC44A1,SMAD7,THBS2,Tpm1,Tpm3,VAT1,WDR37,WDR41 | 1251 (16) |
| SB 216763 | NA | chemical drug | NA | -1.60e+00 | NA | 1.0e-02 | AXIN2,BHLHE40,CCND1,FSCN1,MAF,MYOG,NR4A1,NR4A2,NR4A3,PRDM1,PTGS2,RGS2,RND3,SNAI1,SREBF1,TAGLN | 1515 (17) |
| RHOA | -1.14e+00 | enzyme | NA | -1.60e+00 | NA | 0.0e+00 | ACTA1,ACTA2,BCL2L1,CCND1,CDH1,CDKN1A,COL1A1,COL3A1,CXCL10,ECT2,FN1,FOXP3,ICAM1,IL17A,IRF1,ITGBL1,MMP14,MYOD1,MYOG,NFKBIB,OCLN,PIK3CG,RHOA,RND3,RUNX2,SDC2,SKP2,SNAI2,SREBF1,STAR,TAGLN,TGFB1,VCAM1 | 1466 (21) |
| RAPGEF3 | 2.30e-01 | other | NA | -1.60e+00 | NA | 1.0e-02 | BCL2L11,CTSK,CYP1B1,FN1,PTGS2,SOCS3,SPP1,TGFB1,THBS1 | 1467 (20) |
| TGFBR2 | -6.00e-02 | kinase | NA | -1.60e+00 | NA | 0.0e+00 | ACSL3,ACTA2,ADAMTS5,ADGRE1,ADORA2A,ALOX12,ALOX15,ALOX5,BACE2,BATF,BCAT1,BCL3,BDNF,BGN,BHLHE40,BMP5,C15orf48,C5AR1,CASP1,Ccl2,Ccl7,CCND1,CD200,CD44,CD83,CDH1,CDH2,CDKN1A,CFL1,CLIC4,COL1A1,COL4A6,CRYAB,CSF1,CX3CR1,DDIT4,DNAJC12,EGR1,EGR2,ESPL1,Esrra,FGF2,FGF9,FKBP5,FMOD,FN1,GADD45B,GADD45G,GATM,GFAP,GIPC2,GJB2,GLI1,GLI2,GSR,HDC,HEXIM2,HGF,ICAM1,IKZF2,IL17A,IL2RB,IRF8,ITGAE,ITPK1,JAK3,KDR,KRT19,LTB4R,MAN2B2,MAP3K10,MED11,METRNL,MMP14,MMP2,MRC1,MSR1,MVK,MYOF,NAB2,NFIL3,NFKBIA,NRP1,P2RY12,PDGFB,PDPN,PFN1,PGK1,PGM1,PIK3C2B,PITX2,PKM,PLAGL1,PPARG,PPIA,PTCH1,PTGES,PTGIS,PTGS2,PTPRC,REEP6,RFC5,RPUSD3,RRAD,RUNX2,SCN7A,SCTR,SDC1,SELP,SEMA7A,SERPINE1,SLC12A4,SLC16A3,Slc26a10,SLC2A1,SLC37A4,SMAD7,SNAI1,SOCS3,SORCS2,SPAG1,SPARC,SPP1,SVEP1,TAGLN,TBXAS1,TGFB1,THBD,THBS1,TIMP1,TMPRSS2,TNFRSF11B,TNFRSF4,TPBG,UBE3A,WNT11,ZNF219,ZNF628 | 1559 (19) |
| MOG | -1.90e+00 | other | NA | -1.60e+00 | NA | 0.0e+00 | ARG1,BDNF,C5AR1,Ccl2,Ccl7,CCR1,CCR5,CD44,CD86,CIITA,CXCL10,FOXP3,ICAM1,IGF1,IL17A,ITGAL,MKI67,TGFB1,VCAM1 | 1218 (17) |
| SS18 | -5.80e-01 | transcription regulator | NA | -1.60e+00 | bias | 0.0e+00 | BCL2L11,CACNA1G,DLL1,FOXP3,GADD45B,GCH1,METRNL,PDGFB,RAB40B,RET,RRAD,SLC16A3,SOCS3,SOX8 | NA |
| PAF1 | 5.50e-01 | other | NA | -1.60e+00 | bias | 3.0e-02 | BAMBI,BIRC3,CITED2,IFI44,IFI44L,IFITM3,ISG15,KLF4,OAS3,OASL,SDC4,SERPINE1,ZC3HAV1,ZFP36 | NA |
| CLEC11A | -2.10e+00 | growth factor | NA | -1.61e+00 | NA | 0.0e+00 | ALDOA,ALOX5,ANXA1,BCL2L1,CCR5,CD244,CD74,CDH2,CPA3,CXCL12,EGR2,FHL2,GCSAM,LEF1,LTB4R,Mcpt4,NR4A1,PMP22,RUNX2,S100A6,STAR,TKT | 1430 (19) |
| CCN4 | NA | other | NA | -1.61e+00 | NA | 0.0e+00 | AXIN2,BCL2L1,CCND1,CDH1,CDH2,COL1A1,FN1,RUNX2,SNAI1 | 1114 (20) |
| PTH1R | -2.40e-01 | G-protein coupled receptor | NA | -1.61e+00 | NA | 1.0e-02 | CALB1,CCND1,CDC25B,COL1A1,CSF1,CSF1R,DUSP1,GLI2,NR4A2,SPP1,TNFRSF11B | NA |
| MTA1 | 1.20e-01 | transcription regulator | NA | -1.61e+00 | NA | 1.0e-02 | ACKR3,ACTC1,ADRB2,AXIN2,BCL2L1,CCND1,CCND2,CDH1,EMP1,EZH2,MMP2,MYH6,PIK3R1,PITX2,SNAI1,TWIST1 | 1565 (22) |
| PARP9 | -9.50e-01 | enzyme | NA | -1.61e+00 | NA | 0.0e+00 | BCL6,CD74,HLA-DOB,HLA-DQA1,IFI44,IFIT1,IRF1,ISG15,SP110,STAT1 | 706 (14) |
| MERTK | 2.20e-01 | kinase | NA | -1.62e+00 | NA | 5.0e-02 | FGL2,HDC,HGF,IL17A,INHBA,MYL2,PLAGL1,RGCC,RILPL1,SLA,ZC3H12C | NA |
| COP1 | NA | enzyme | NA | -1.62e+00 | NA | 0.0e+00 | C3,CA12,CALCR,CBFA2T3,CDKN1A,CISH,CXCL10,CYP26B1,EGR3,ETV5,GFRA1,GPNMB,ICAM1,IFI16,IGFBP4,ITPK1,KAZN,OLFML3,OVOL2,RARA,RET,SEMA3B,SLC39A6,SREBF1,TPD52L1,TSKU | 1345 (15) |
| GNA13 | 7.20e-01 | enzyme | NA | -1.62e+00 | bias | 1.0e-02 | ACTA2,Ccl2,CNN1,EGR1,GNA13,mir-143,PTGS2,TAGLN,TRPC6 | 1158 (21) |
| GNRH1 | -2.50e-01 | other | NA | -1.62e+00 | NA | 0.0e+00 | APCDD1,CDH11,CHRNA4,CREM,EGR1,EGR2,IGF1,IGFBP5,IL2RA,INHA,INHBA,INHBB,MEDAG,NOS1,NR5A1,PLAT,PPP3CA,PRKCD,PRKCE,PRKCQ,PTGS2,RASSF10 | 1916 (23) |
| CD5 | NA | transmembrane receptor | NA | -1.63e+00 | NA | 0.0e+00 | BCL3,CD86,GZMB,ICAM1,IL10RB,IL17A,IL2RA,IL2RG,LSM3,MAP2K2,MSMO1,MVK,NR4A1,RARA,SIPA1,STAT1,TGFB1,TLR8 | 1148 (19) |
| CTNND1 | -3.40e-01 | other | NA | -1.63e+00 | NA | 2.0e-02 | CDH1,CDH2,CDH3,SNAI1,VIM | NA |
| zymosan | NA | chemical - endogenous non-mammalian | NA | -1.63e+00 | NA | 0.0e+00 | ARG1,ARNT2,Ccl2,CCL24,CD86,CIITA,Crip2,CSF1,CXCL10,CXCL12,Esrra,FTL,HIF1A,IKBKE,IL17A,IRF4,LPL,MMP2,PPARGC1B,PTGS2,RXRA,SLC27A1,SOCS1,SOCS3,SPN,TLR2 | 916 (14) |
| CHIT1 | 3.70e-01 | enzyme | NA | -1.63e+00 | NA | 0.0e+00 | ACTA2,COL1A1,ELN,FN1,SMAD7,VIM | 986 (15) |
| S100A4 | -1.57e+00 | other | NA | -1.63e+00 | NA | 0.0e+00 | CCL24,CDH1,CDKN1A,CLIC4,FN1,ICAM1,MMP14,MMP2,NOTCH2,OCLN,SNAI1,THBS1,TIMP1,TPO,TWIST1,VCAM1,VIM | 1031 (18) |
| trypsin | NA | group | NA | -1.63e+00 | NA | 1.0e-02 | CDH1,CDKN1A,ELN,F3,ICAM1,PTGS2 | NA |
| ST6GAL1 | -9.50e-01 | enzyme | NA | -1.64e+00 | NA | 0.0e+00 | ANO6,ATP2B4,BIRC3,CAV1,CCND2,CDH1,CDH2,FN1,HIF1A,ITGA2,MET,OCLN,PLXND1,SLC2A1,SLC9A1,SNAI1,SNAI2 | 1360 (19) |
| UBR5 | NA | enzyme | NA | -1.64e+00 | NA | 1.0e-02 | BATF,CCND1,CDKN1A,CFH,CXCL10,DAPK1,IFIH1,IKZF2,IL17A,IL1RL2,IRF1,ISG15,NRP1,OAS3,OLR1,PIK3C2G,SELP,STAT1 | 1354 (16) |
| PAK4 | 2.40e-01 | kinase | NA | -1.64e+00 | NA | 1.0e-02 | CDH1,CDH2,NOX1,PPARG,SNAI2,VIM | NA |
| vadimezan | NA | chemical drug | NA | -1.64e+00 | bias | 3.0e-02 | CXCL10,ICAM1,IRF1,ISG15,NFKBIA,SELE | NA |
| L-glutamic acid | NA | chemical - endogenous mammalian | NA | -1.64e+00 | NA | 0.0e+00 | ACTA2,B2M,BCL2L1,BCL2L11,BDNF,CALB1,CASP3,Ccl2,CCND1,CDH2,CDKN1A,CDS1,CETN2,CLDN1,DLK1,EGR1,FADS1,FADS2,FGF2,FMO2,GADD45B,GRIA2,HIF1A,HOMER1,MAL,MAP1B,MAP2,MITF,MMP2,MSMO1,NFIL3,NOS1,NOX1,OCLN,PER1,PLA2G4A,PLP1,PTGS2,RHOA,ROCK1,RUNX2,Scd2,SELENOP,SLC1A1,SLC1A3,SLC25A38,SLC27A1,TIMP1,TOR3A | 1226 (17) |
| PRKCA | 4.90e-01 | kinase | NA | -1.64e+00 | NA | 0.0e+00 | ACTA1,ARHGDIB,BCL11A,BCL2L1,CAV1,CCND1,CD36,CDKN1A,CHRND,CIITA,COL1A1,CXCL10,CYBB,DTX1,EGR1,ETS1,FN1,FOXO1,GFAP,HSPA1A/HSPA1B,ICAM1,ID2,IFIT1,IL17A,LAMP2,LPL,NFKBIA,NOTCH4,OASL,PLD1,PRKCD,PTGS2,RSAD2,RUNX1,RUNX2,SELP,SERPINE1,SREBF1,STAR,VCAM1 | 1090 (14) |
| HSPA9 | 3.10e-01 | other | NA | -1.64e+00 | NA | 3.0e-02 | CDH1,CDKN1A,FN1,FOXO1,HOXD10,MMP2,MYCN,NEDD9,PRDM16,RET,TIMP1,VIM | NA |
| MAPK9 | -1.40e-01 | kinase | NA | -1.65e+00 | NA | 0.0e+00 | ADIPOQ,BCL2L11,BIRC3,BMP1,BMP4,CACNB3,CAV1,Ccl2,Ccl7,CDKN1A,DLK1,EDN1,EGF,EGR1,F3,FGL2,FOXP3,GADD45A,GADD45B,GAPDH,HDC,HIF1A,IFI16,IL15RA,ITGB4,JUND,KLF6,LPL,LSM3,MARCKSL1,NMI,OCLN,PARP14,PLA1A,PLA2G4A,PLAT,PPARG,PTCH1,PTGES,PTX3,RBL1,RILPL1,SREBF1,TNFSF8,ZFP36 | 1172 (14) |
| GPI | 1.16e+00 | enzyme | NA | -1.65e+00 | NA | 0.0e+00 | CAV1,CCND1,CDH1,FN1,RHOA,SKP2,SNAI1,VIM,ZEB2 | 1451 (19) |
| dicarbethoxydihydrocollidine | NA | chemical toxicant | NA | -1.66e+00 | NA | 2.0e-02 | ABCC3,ABCC4,BCL2L11,Ccl2,CCNA2,KRT19,PROM1,SGK1,SPP1,VCAM1 | NA |
| mir-182 | NA | microRNA | NA | -1.66e+00 | NA | 0.0e+00 | ARG1,CARD11,CCL24,CD200R1,CDH1,CDK6,CHI3L1,CSF1R,CXCL12,CXCL13,FN1,FOXO1,FOXO3,GADD45G,GJA3,INHBC,IRF4,ITGA4,JAG1,KLF4,MRC1,MTSS1,NCAM1,OCLN,RPS6KB1,SLC39A9,SOCS3,TLR4,VIM,VWF | 1236 (18) |
| SRC | -1.80e-01 | kinase | NA | -1.66e+00 | NA | 0.0e+00 | ABCA9,ABCG1,ATP8B1,BCL2L1,CAV1,CCND1,CCND2,CDH1,CDKN1A,CDON,CKM,CXCL10,DUSP1,F2R,F3,FGR,FN1,HAS2,HCN4,HIF1A,ICAM1,LAMP2,MMP2,MYOD1,MYOG,PGK1,PLAT,PLK1,PRKCD,PRKCE,PTGS2,SIRPA,SLC2A1,SPP1,TFPI2,TWIST1,VCAM1,VEGFC,VIM | 1226 (13) |
| IRAK3 | -7.30e-01 | kinase | NA | -1.66e+00 | NA | 2.0e-02 | ACTA2,BCL2A1,Ccl2,COL1A1,INPP5D,IRF5,NFKBIA,SOCS1,TGFB1,VIM | NA |
| ethanol | NA | chemical - endogenous mammalian | NA | -1.66e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACADL,ACKR3,ACTA1,ACTA2,ADAM17,ADH1C,ADIPOQ,ALDH1A1,ALDH1A3,ALOX5,ANPEP,AQP4,ARHGDIB,ATF3,AXIN2,BCL2L1,BDNF,BMP4,C3AR1,C5AR1,CAPN5,CASP3,Ccl2,Ccl7,CCND1,CD36,CD44,CDKN1A,CEBPD,CFL1,CHRNA4,CLIC4,CNR1,COL3A1,Cox8b,CREB1,CRP,CXCL12,CXCR4,CYP27A1,CYP7B1,DDR2,DUSP1,DUSP6,EDN1,EDNRB,EGR1,EIF3G,EIF6,EPHX1,ESRRB,EZH2,FAAH,FABP1,FGF2,FGFR1,FLNA,GADD45A,GAPDH,GBP2,GFAP,GNAI1,GNAS,GPAM,GPM6A,GREM2,GSR,Gsta4,GZMB,HIF1A,HLA-A,HOMER2,ICAM1,Ifi47,IL16,IL1R1,IL1RN,IL33,IRF3,KLF4,KLF6,LGALS1,LPIN1,LSS,MAG,MAP1B,MAP1LC3A,MAP1LC3B,MAP2,MAP2K4,MAT2A,MCOLN1,MME,MMP2,MOG,MYCN,MYOF,NCEH1,NCF1,NCF2,NFE2L2,NKD1,NMI,NR2F1,NTRK2,NUDT5,OCLN,PKM,PLAT,PLIN1,PLK3,PNPLA2,PPARG,PPM1A,PPP1R3C,PRAF2,PRDX4,PRKAA1,PROM1,PTGS2,RAB3D,RGCC,SALL4,SEC23A,SELE,SERPINE1,SGK1,SH3BGRL,SLC25A6,SNAI1,SNX10,SOX18,SREBF1,STAR,STAT1,STAT5B,TFCP2L1,TFPI2,TGFB1,TIMP1,TLR2,TLR4,TLR7,TLR8,TNFAIP6,TUBA1A,VCAM1,WEE1,ZEB2,ZNF281 | 1447 (16) |
| GATA5 | NA | transcription regulator | NA | -1.66e+00 | NA | 0.0e+00 | ACTC1,EDN1,HBA1/HBA2,MYH6,MYH7,SLC9A3,TNNC1 | 977 (7) |
| enterolactone | NA | chemical - endogenous mammalian | NA | -1.66e+00 | NA | 0.0e+00 | CCND1,IL1RN,KDR,MKI67,SPARC,SPP1 | 662 (7) |
| MAPK8 | -5.00e-02 | kinase | NA | -1.67e+00 | NA | 0.0e+00 | ABCA1,ADIPOQ,APOD,B4GALT1,BCL2L1,BCL2L11,BIRC3,BMP4,BTRC,CASP3,Ccl2,CCNA2,CCND1,CDH1,CDH2,CDK2,CDKN1A,COL1A1,CRP,CXCL16,CYBB,CYP27A1,DUSP1,DUSP6,EGF,EGR1,ETS1,FOXO1,GADD45A,IL2RA,JUND,KLF6,MAOB,MMP2,MSR1,MYOG,NEFL,NOX4,NRP1,OCLN,PPARD,PPARGC1B,PTCH1,PTGES,PTGS2,PTX3,RARA,RGS4,SELE,TLR2,VEGFC,WNT4,WNT5A,WNT6,ZFP36 | 1477 (17) |
| FGF19 | NA | growth factor | NA | -1.67e+00 | NA | 0.0e+00 | ACSL1,Akr1b7,ALDH1A1,AQP4,BCL2L1,BTG3,CCND1,CD36,CTSE,CYP7B1,EGR1,ENO3,G0S2,GADD45A,GAS2,IL1RN,LEPR,MME,NR0B2,PPARGC1B,PROM1,RGS2,Scd2,SCN1B,SGK1,SLC2A5,SREBF1,ST6GAL1,TNNI1 | 1371 (20) |
| VGLL3 | -3.50e-01 | other | NA | -1.67e+00 | NA | 0.0e+00 | ANKRD1,COL12A1,COL1A1,GADD45B,OSR2,Ptprv,SNAI2,SPP1,THBS1 | NA |
| PLK4 | -1.56e+00 | kinase | NA | -1.67e+00 | NA | 3.0e-02 | Ccl7,CITED2,CXCL10,EDN1,FGL2,IL15RA,IRF1,PLAT,RBL1 | NA |
| HOXB13 | NA | transcription regulator | NA | -1.67e+00 | NA | 4.0e-02 | ATP10D,CCND1,CDKN1A,EPHA4,LRRN1,NFKBIA,NIPAL1,POPDC3,SEMA3A | NA |
| PSMD10 | -5.00e-02 | transcription regulator | NA | -1.67e+00 | NA | 0.0e+00 | CCND1,CDH1,CDK2,CDKN1A,EIF4EBP1,G6PD,GNAS,HIF1A,ICAM1,IKBKB,ME2,MRAS,MTHFD2,TKT,TWIST1 | 1324 (17) |
| MUC4 | NA | other | NA | -1.67e+00 | NA | 0.0e+00 | CCND1,CDH1,CDH2,CDKN1A,ERBB3,SNAI1,TWIST1,TWIST2,VIM | 1442 (20) |
| CSF3 | 8.50e-01 | cytokine | NA | -1.67e+00 | NA | 0.0e+00 | ADGRE1,ARG1,ARHGEF10,BATF,BCL2L1,BIRC3,C3AR1,Ccl2,CCND2,CD300LD,CD300LF,CD34,CD44,CDK2,CDK6,CEBPD,CHP1,CISH,CNKSR2,CRTC1,CSF3R,CX3CR1,CXCL12,CXCR4,CYBB,DUSP6,EDN1,EGR1,EGR2,EGR3,ENTPD1,ETS1,FARP1,FCGR1A,FLOT1,GADD45A,GADD45B,GADD45G,GATA4,GFAP,GNB4,GPR183,GZMB,HDC,HGF,HLA-DQA1,HLA-DRA,ICAM1,IGF1,IL1RN,IL7,ITGB2,JAK3,KIT,KITLG,LBP,MET,MMP2,MYH10,NCDN,NFIL3,NTRK2,PPARG,PRKCB,PRKCE,Prrt1,PTGS2,RAB27A,RARA,SLC20A2,SOCS1,SOCS3,TAGLN,TAL1,TGFB1,TLR2,TLR4,TLR5,TLR8,TNFRSF1B,Tpm1,VCAM1 | 1274 (13) |
| MAX | 8.20e-01 | transcription regulator | NA | -1.67e+00 | NA | 0.0e+00 | ACTC1,BCL6,BCR,Ccl6,CCND2,CDKN1A,CSDE1,DKC1,E2F2,EBF1,EDN1,EZH2,FADS2,FBXO32,GADD45A,GADD45B,ID2,IRS2,KLF10,KLF6,LAMP2,LOC100359583/Ptma,MYCT1,MYH6,RBBP4,RHOA,SLC2A1,TNNT2 | 767 (7) |
| ADCY | NA | group | NA | -1.68e+00 | NA | 0.0e+00 | CDH2,CDKN1A,COL3A1,CREM,CRYM,CYP1B1,ENTPD1,FGF2,ITGA2B,NR4A2,PER1 | 1359 (20) |
| ILK | 1.10e-01 | kinase | NA | -1.68e+00 | NA | 1.0e-02 | CCND1,CD44,CDH1,CDKN1A,FN1,IKBKB,ITGA6,LEF1,LIMS1,MAPK3,MMP2,MYH7,MYOG,SNAI1,TGFB1 | 1343 (20) |
| daidzein | NA | chemical drug | NA | -1.68e+00 | NA | 0.0e+00 | A2M,ABCA1,ABCC3,ABCG1,ADIPOQ,AIF1,ARG1,BDNF,CASP3,CAV1,CCND1,CD86,DNASE1L3,EVI2A,FCGR2B,FCMR,GFAP,HLA-A,HLA-DQA1,ID2,ITGB2,LCP2,LY86,MAL2,MAP4K1,MMRN1,MTMR1,NFE2L2,OSBPL3,PIK3R1,PKIB,PTGS2,PTPN6,RASAL3,RASGRP1,Rnase2 (includes others),SIGLEC10,SREBF1,SYP,ZEB2,ZNF212 | 1850 (21) |
| cyanocobalamin | NA | chemical - endogenous mammalian | NA | -1.68e+00 | NA | 0.0e+00 | EGF,FGF10,FZD1,FZD6,GFAP,Mbp,PER1,PITX2,PTCH1,SFRP1,WNT4,WNT6 | NA |
| CEBPD | 1.43e+00 | transcription regulator | NA | -1.68e+00 | NA | 0.0e+00 | ASNS,BCL2A1,BRCA2,C3,Ccl2,CCND1,CDKN1A,CEBPD,CSF1R,CSF3R,CXCR4,GFAP,HGF,HIF1A,IGF1,IGFBP5,IKBKE,MIA,MITF,MPZ,NOX1,PAX3,PDGFRA,PPARG,PRKDC,PTAFR,PTGS2,SLC2A1,SNAI2,TLR8,TNFAIP6,VEGFC | 1456 (21) |
| STAT | NA | group | NA | -1.69e+00 | bias | 0.0e+00 | A2M,BCL2L1,CASP1,CDKN1A,CEBPD,CISH,CRP,IL2RA,IRF1,LBP,SMAD7,SOCS1,SOCS3,TIMP1 | 1325 (17) |
| NfkB-RelA | NA | complex | NA | -1.69e+00 | bias | 5.0e-02 | BCL2L1,CXCL10,HIF1A,ICAM1,IRF1,NFKBIA,PTGS2,SELE,SOCS3,VCAM1 | NA |
| MEF2D | 3.40e-01 | transcription regulator | NA | -1.69e+00 | NA | 0.0e+00 | ACTA1,BDNF,CCND1,CCNE2,CDH1,CDK2,CKM,COL3A1,EGR2,FN1,GCLC,Gsta4,HDAC9,IRF4,JUND,MEOX2,MYH7,MYOCD,MYOD1,MYOG,NFE2L2,NR4A1,STAR,SYK,TGFB1,TNNC1,TNNI1,VIM,ZFP36 | 1394 (20) |
| 3-methyladenine | NA | chemical toxicant | NA | -1.69e+00 | NA | 1.0e-02 | ACTA2,ADAMTS5,ADIPOQ,ALDH1A1,CASP3,CCNA2,CD86,GFAP,IL1RL1,IL33,MAP1LC3B,PTGS2,RUNX2,S100A10,SNAI1,SNCA,TGFB1,VIM | NA |
| THRB | -2.00e-02 | ligand-dependent nuclear receptor | NA | -1.70e+00 | NA | 0.0e+00 | ACTA1,AMPD3,ATP2A2,BCL3,BIRC3,BTG2,CASP1,CASP3,CASP8,Ccl2,CCND1,CCND2,CCR1,Cd33,CDCA7L,CDH6,CDK6,CTSH,CXCL10,CXCR4,DAD1,DCN,DIO1,EGF,ENG,ERBB3,FGFR1,FRZB,FSTL1,FZD1,FZD4,FZD6,GCH1,GJA5,HCN4,HIF1A,IL7,KLF9,LEF1,LPL,MAPK14,MAPK3,MC4R,MET,MLKL,MMP2,MYH6,MYH7,NCF1,NCOR2,NKD1,NLRP3,NMNAT1,NOX4,NR4A1,NR5A2,Oasl2,PAM,PDK4,PENK,PER1,PITX2,PLA2G2A,PLIN1,PPARG,PROM1,PTAFR,PTGS2,RIPK3,RUNX2,SERPINE1,SFRP1,SFRP2,SFRP4,SH2D4A,SKP2,SLC25A45,SPP1,SREBF1,STAT5B,STRA6,TCEA3,Tcf7,TECTB,TGFB1,TGFBI,TLE2,TLR2,TNFRSF10A,Tnfrsf26,TP63,TRADD,TSHR,UCP3,WNT11,WNT16,WNT2,WNT2B,WNT4 | 1608 (23) |
| NCOA2 | 3.80e-01 | transcription regulator | NA | -1.70e+00 | NA | 0.0e+00 | ADIPOQ,AHR,BCAS1,C1R,C3,Ccl2,CCND1,CDKN1A,CIITA,CXCL10,EGR1,ESRRB,FAM89B,Fcrls,FRZB,GBE1,GBP5,GLO1,GPD2,GPR34,GPX3,GPX8,HCAR2,HLA-A,IP6K2,IRF1,IRF4,ISG15,KHK,KLF4,KRT19,LIPG,LPIN1,LPL,MC2R,MYOG,NFKBIA,NR4A2,NR4A3,OAS3,OASL,P2RY12,PLIN1,PLTP,PPARG,PPP1R3B,PPP1R3C,PRDX1,PTGS2,RARA,RARG,RET,SALL4,SFTPB,SLC3A1,SREBF1,STAR,UCP3 | 1171 (21) |
| Pka | NA | complex | NA | -1.70e+00 | NA | 0.0e+00 | ANTXR1,ANTXR2,CAV1,CD44,CDH2,CDK2,CDKN1A,CREM,CXCL10,DUSP1,EDN1,EGR1,HAS2,HOMER1,IGF1,IRF1,KLF6,Mbp,NCF1,NOX1,NR4A1,NR4A2,NR4A3,NTS,OXTR,PDE4D,PENK,PLD1,PNMT,PRKCZ,PTGS2,RGS2,RUNX1,SFTPB,SGK1,SLC1A3,SREBF1,STAR,TNFRSF11B | 1245 (18) |
| IFT57 | 3.70e-01 | other | NA | -1.70e+00 | NA | 4.0e-02 | BDNF,CASP1,CASP3,CASP8,PENK,PTCH1 | NA |
| CXCL5 | NA | cytokine | NA | -1.70e+00 | NA | 2.0e-02 | ACTA2,CDH1,COL1A1,COL3A1,ITGAL,SNAI1 | NA |
| NOS1 | 1.48e+00 | enzyme | NA | -1.71e+00 | NA | 2.0e-02 | ADIPOQ,BDNF,EGR1,FBXO32,HIF1A,PDE5A,SLC2A1,SOCS1,TRIM63 | NA |
| RARRES2 | -4.40e-01 | transmembrane receptor | NA | -1.71e+00 | NA | 3.0e-02 | ADIPOQ,ALDH1A3,Ccl2,CCNA2,CCND2,CD44,CDH2,PLIN1,VCAM1 | NA |
| TBXT | NA | transcription regulator | NA | -1.71e+00 | NA | 5.0e-02 | ALCAM,CD44,COL1A1,COL2A1,DUSP6,FMOD,ITGA3,KDR,MITF,SOX6 | NA |
| STIM1 | -9.00e-02 | ion channel | NA | -1.71e+00 | NA | 0.0e+00 | BCL2L1,CAMK1D,CDK6,CDKN1A,CREB3L1,FGF9,FOXO1,GCLC,ITGA11,ITGA5,ITGA6,KDR,KLF10,KLF15,KLF3,KLF4,MYBL1,NFATC3,OAS3,PRDX1,PTCH1,SMO,TGFB1,TPO,TSHR,WNT2 | 1171 (18) |
| GREM1 | -2.08e+00 | other | NA | -1.71e+00 | NA | 1.0e-02 | AXIN2,CDKN1A,COL1A1,ELN,RET,RUNX2,WNT11 | 1323 (20) |
| MALAT1 | NA | other | NA | -1.71e+00 | NA | 4.0e-02 | CASP3,CDH1,HIF1A,SNAI1,SNAI2,TWIST1,VIM | NA |
| TAL1 | -7.90e-01 | transcription regulator | NA | -1.71e+00 | NA | 0.0e+00 | ACOT8,BCL6,BUB1,C3,C3AR1,CACNG4,CD7,CDK6,CDKN1A,CEP70,CHST11,CIB2,CMA1,CPLX1,CWC27,DNMBP,EEF1E1,ELOVL4,EPB42,ETS1,FBN1,GALNT7,HIVEP3,HLA-A,ICAM1,ID2,IL10RA,KCNJ9,KIT,LMO1,LYST,MAP2,MCTP1,MS4A2,MSLN,MVD,MYOG,N4BP2L1,NCAPG,NDN,NEFL,NFYA,NOS1,NR4A3,NTNG2,P2RY1,PLA2G2A,PLEKHO1,PPP3CA,REL,RUNX1,SLAMF1,SYK,TMEFF1,TOX,TSHR,UBXN1 | 1025 (18) |
| ITGAV | -5.60e-01 | transmembrane receptor | NA | -1.71e+00 | NA | 0.0e+00 | AMIGO2,BCL2L1,Ccl2,CD36,CDH1,CDKN1A,COL1A1,CXCL10,FN1,GBP2,Ggta1,HAS2,HLA-A,ICAM1,ITGA1,ITGA5,ITGB3,MMP2,RUNX2,SERPINE1,TGFB1,TIMP1 | 1355 (19) |
| concanamycin A | NA | chemical drug | NA | -1.72e+00 | NA | 4.0e-02 | ICAM1,MET,NFKBIA,PPARG,SELE,VCAM1 | NA |
| FOXL2 | NA | transcription regulator | NA | -1.72e+00 | NA | 2.0e-02 | ACVR1,ACVR1C,ATF3,BCL2A1,CYP26B1,ESM1,HMCN1,HRH2,ICAM1,IER3,IGF1,INHBA,MAFF,NFE2L2,NR4A3,NR5A1,NR5A2,OSR2,PTGS2,RGS2,RSPO3,SMAD6 | NA |
| Hbb-b1 | NA | transporter | NA | -1.72e+00 | NA | 0.0e+00 | BCL2L11,Ccl2,Ccl7,CCR5,CD44,CD74,CIITA,CMTM3,COX6A2,CXCL10,CXCR5,CYBA,CYBB,FN1,FTL,HIF1A,ICAM1,IL10RA,IL16,IL2RB,IL2RG,LY86,Mt1,NCF2,NDUFA7,NDUFB9,NDUFC1,NDUFS7,NDUFV1,NDUFV2,RET,SERPINF2,TLR2,VCAM1,VEGFC | 1034 (12) |
| CCL2 | -9.00e-02 | cytokine | NA | -1.72e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACTA2,ADIPOQ,BCL2L1,Ccl2,CCND1,CD86,CEBPD,CXCL10,F3,FOLR2,HDC,HTR2B,ICAM1,IGF1,INHBA,ITGA1,ITGA5,ITGAL,KLF4,LPL,MKI67,MMP2,NCF1,OCLN,PPARG,PTGS2,RNF128,SERPINE1,STAT1,TGFB1,TIMP1,TP63,VCAM1 | 1370 (17) |
| BMP4 | -7.40e-01 | growth factor | NA | -1.72e+00 | NA | 0.0e+00 | ACTA2,BMP4,Cald1,CCND1,CDH1,CDK2,CDKN1A,CNN1,COBLL1,COL2A1,CXXC5,DEK,FOXP3,GREM1,HOPX,ID2,INHA,INHBA,INHBB,ITGA4,KDR,KIT,KLF10,KLF4,L1CAM,LCP1,LEF1,MFAP5,MITF,MMP14,MYCN,MYH2,MYH7,NCAM1,OVOL2,PAPPA2,PFKFB3,PITX2,PKM,PPARD,PPARG,PRKCB,PRR5,PTCH1,RET,RUNX2,SERPINE1,SLC38A3,SMAD6,SMAD7,SMAD9,SNAI1,SNAI2,SPARC,SPNS2,STAR,TAGLN,TAL1,TBX3,TBX5,TNFRSF11B,TNNT2,TP63,TRPV2,VTCN1,WNT5A | 1753 (22) |
| deferasirox | NA | chemical drug | NA | -1.72e+00 | NA | 0.0e+00 | ANXA2,CDH1,F13A1,FAM20C,GAS7,ITGB2,KIT,LRRC25,LY75,MS4A6A,PLCB1,PPARG,SERPINB8,SULF2,UBE2E1 | NA |
| MIAT | NA | other | NA | -1.72e+00 | NA | 1.0e-02 | ALPK2,CSRP2,CXCL13,DHRS9,EXT1,FCGBP,FMOD,IL17A,NFKBIB,PSTPIP1,RAB38,RXRA,RYR1 | NA |
| Fgf | NA | group | NA | -1.72e+00 | NA | 0.0e+00 | CCND1,CDH1,IGF1,KDR,LPCAT1,MITF,MMP2,PER1,PTGS2,RUNX2,SPRY4,STAT1,VCAM1 | 1505 (22) |
| ROR2 | 4.00e-02 | kinase | NA | -1.73e+00 | NA | 3.0e-02 | ABRACL,ADGRG3,AXIN2,BANF1,BOLA1,CCND1,CCND2,CDKN1A,ERAP1,MAP1B,MAP1LC3B,MAP2,NOTCH2,NTHL1,PMP22,PPARG,PTPN6,RHOA,SPRY4,USP46,WEE1,WNT11,WNT5A,WNT6 | NA |
| Growth hormone | NA | group | NA | -1.73e+00 | NA | 0.0e+00 | ACSL1,ADIPOQ,ADRB2,ARID5B,BCL6,BMP4,C3,CA3,CALB1,CCND1,CCND2,CD36,CDH1,CDH3,CEBPD,CISH,CITED2,COL18A1,COL1A1,COL3A1,CRHR2,CX3CL1,DDR1,DLK1,EGR1,FKBP5,FN1,FZD5,G6PD,GCLC,GFAP,ICAM1,IER3,IGF1,IGFALS,IGFBP5,IGFBP6,IRF1,KLF10,LEPR,LOC259246 (includes others),LPL,mir-133,MSTN,MYOD1,NEDD9,NFKBIA,NOX4,OCLN,PDK4,PFKFB3,PIK3C2B,PLK2,PPARG,Pzp,S100A4,S100B,SGK1,SLC2A1,SNAI2,SOCS1,SOCS3,SPP1,TGFB1,TKT,TUBA1A,Ubb,UGDH,WNT9A,ZEB2 | 1645 (21) |
| CCL18 | NA | cytokine | NA | -1.73e+00 | bias | 3.0e-02 | MMP2,S100A4,SNAI1,TGFB1 | NA |
| HDAC7 | -7.00e-01 | transcription regulator | NA | -1.73e+00 | NA | 4.0e-02 | ALCAM,CCND1,CD44,CDH1,CDKN1A,EDN1,NR4A1,SNAI1 | NA |
| LGALS3 | -5.50e-01 | other | NA | -1.73e+00 | NA | 0.0e+00 | ADIPOQ,ARG1,CASP3,Ccl2,CCND1,CCR1,CDKN1A,COL3A1,COL5A2,CTSH,DUSP6,FN1,FSCN1,GFRA1,ICAM1,IGF1,IGFBP5,ITGA10,ITGA6,KRT19,LGALS12,MAP3K10,MGST1,MRC1,MSR1,PNPLA2,PPARG,PRDM1,PRKCZ,SELE,SOCS3,SPP1,TGFB1,VCAM1,WNT9A | 1290 (17) |
| Wy 40905 | NA | chemical reagent | NA | -1.73e+00 | NA | 0.0e+00 | AGPAT1,ANXA5,ATF3,BTG2,CD53,CDKN1A,CREM,EGR1,EGR2,GADD45B,GCNT2,KLF4,KLF6,MVK,NR4A1,PER1,RGS2,RRAD,SCN1B,SERPINB9,SERPINE1,TMBIM1,UHMK1,ZFP36 | 1244 (19) |
| nonylphenol | NA | chemical toxicant | NA | -1.73e+00 | NA | 3.0e-02 | ADIPOQ,CXCL10,HSPA1A/HSPA1B,IKBKB,LBP,LCP2,Ldha/RGD1562690,PFKFB4,PTGS2,S100A6,SLC1A5,SLFN12 | NA |
| WBP2 | 9.00e-02 | transcription regulator | NA | -1.73e+00 | NA | 0.0e+00 | ADRM1,ALPK2,AXIN2,BMP4,CDK15,COL4A6,COL6A3,COLEC12,CORO1C,CSPG4,CST7,EGR1,FCMR,FHL1,GGT5,HAS2,ITGB3,LEF1,LGR5,LIPG,MAPRE3,MBOAT1,MOB3A,MTMR1,NECTIN1,PDAP1,POLG,PTGS2,SLC10A3,SLC16A3,SLC1A3,STX3,SYTL3,TAGLN,TEF,UCN2,WLS,ZNF367 | 1097 (7) |
| isotretinoin | NA | biologic drug | NA | -1.73e+00 | NA | 3.0e-02 | ABCA1,ABCG1,ALDH1A3,BCL2L1,CDKN1A,CYP1B1,GAP43,HOXA5,IRF1,OLR1,PTGIS,PTGS2,RARA,RARG,RARRES1,SKP2,SPN,TLR2,TNFAIP2,VCAM1 | NA |
| 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine | NA | chemical reagent | NA | -1.74e+00 | NA | 0.0e+00 | ACTA2,BCL2A1,BIRC3,COL8A1,ICAM1,MYH6,MYOCD,PMEPA1,PTGS2,SNAI1,TGFB1,TWIST1,VCAM1,VIM | 914 (15) |
| amphetamine | NA | chemical drug | NA | -1.74e+00 | NA | 0.0e+00 | ASIC2,ATF3,BCL2L1,BDNF,BMP4,BUB1,CAMK2A,CD47,CDH2,CREB1,CSF1R,EGR1,EZR,F3,FAP,FGF10,HIVEP3,ICAM1,INHBA,MAOB,MYBL1,NOS1,NTS,OCLN,RDX,RGS2,SGK1,SNCA,SYP | 1340 (25) |
| SCAP | 2.30e-01 | other | NA | -1.74e+00 | NA | 1.0e-02 | AACS,ABCA1,ACSL1,ACSL5,ASNS,ATF3,CSF1R,CYP4F2,DHCR7,DLK1,ELOVL5,FADS1,FADS2,GPAM,LSS,MSMO1,MTHFD2,MVD,MVK,OLR1,PTGS2,Scd2,SLC7A1,SREBF1 | NA |
| CPT1B | -4.00e-02 | enzyme | NA | -1.74e+00 | NA | 0.0e+00 | ACADL,ACSL1,AGPAT2,ATP2A2,Calm1 (includes others),COX4I1,COX6B1,EIF4EBP1,FBP2,FLOT1,FOXO1,FUBP1,GPAM,HK1,IKBKB,INPP5D,IRS1,IRS2,LPL,MAP2K2,MAPK3,MB,NDUFA1,NDUFA7,NDUFAB1,NDUFB3,NDUFB9,NDUFC1,NDUFV1,NDUFV2,NFKBIA,PDE3B,PDK4,PFKFB3,PHKB,PHKG1,PIK3CG,PIK3R1,PIK3R3,PPP1R3A,PPP1R3B,PPP1R3C,PRKAA1,PRKAA2,PRKAB1,PRKAB2,PRKAG3,PRKAR2B,PRKCI,PRKCZ,PRKX,PTPRF,PYGL,PYGM,RPS6KB1,SHC2,SHC4,SLC27A1,SOCS1,SOCS3,SREBF1,TNFRSF8,UQCR10,UQCR11 | 421 (7) |
| GABPB1 | 2.10e-01 | transcription regulator | NA | -1.74e+00 | bias | 0.0e+00 | CHRND,COX4I1,IL16,ITGB2,OXTR,SKP2,TNC,TSHR,UCP3,UTRN | NA |
| Angiotensin II receptor type 1 | NA | group | NA | -1.74e+00 | NA | 2.0e-02 | ATP1A1,CXCL10,EDN1,GAP43,HIF1A,SERPINE1,TIMP1 | NA |
| TNFSF15 | -8.80e-01 | cytokine | NA | -1.75e+00 | NA | 3.0e-02 | ABCG1,ACTA2,BIRC3,CD83,CD86,CDH2,FN1,GZMB,IL17A,IL2RA,IL2RB,SPP1,VIM | NA |
| TBX2 | NA | transcription regulator | NA | -1.75e+00 | NA | 0.0e+00 | ATF3,BHLHE40,BUB1,CCNA2,CDH1,CDKN1A,CDKN2C,DBP,E2F7,E2F8,ELK3,EZH2,FAM120B,MCM7,NCAPG2,NFIL3,PCGF6,PHTF2,PLK1,PRC1,RBL1,SGO1,SMC2,TCEA2 | 1396 (19) |
| dextran sulfate | NA | chemical drug | NA | -1.75e+00 | NA | 0.0e+00 | ADAMTS1,AHR,ARG1,BDNF,BMP4,BUB1,BUB1B,C3,CARD11,CASP1,Ccl2,CCNA2,CCND1,CD36,CD74,CD83,CD86,CDKN1A,CFH,CLDN1,COL18A1,CX3CR1,CXCL10,E2F7,E2F8,EFNA5,EGF,ENG,EPHB4,ETS1,FANCA,FANCB,FGF1,FGFR1,FZD10,GADD45GIP1,GLI1,GLI2,HGF,ICAM1,IFITM3,IL17A,ISG15,ISLR,KIF11,KNTC1,LCP1,MKI67,MMP14,MMP2,MRC1,MSR1,NLRP3,NOX1,NRP1,OCLN,OSMR,PDGFB,PHGDH,PITX3,PLK1,PRC1,PTAFR,PTGS2,PTN,PTP4A3,RBBP4,REC8,RHOA,SDC1,SELP,SERPINE1,SGO1,SKA1,SLC2A1,Slfn2,SMC2,SOCS3,SORT1,SPC25,SPHK1,ST14,STMN1,THBS1,THBS2,THBS4,TLR4,TNFRSF1B,TOP2A,UHRF1,VCAM1,VEGFC,VEGFD,WNT11,WNT16,WNT2,WNT2B,WNT4,WNT5A,WNT6 | 1096 (16) |
| POU2AF1 | -2.00e-02 | transcription regulator | NA | -1.75e+00 | NA | 0.0e+00 | B4GALT1,BCL2L1,BCL6,CCR5,CD44,CD74,CD83,CD86,CXCR4,CXCR5,DAPK1,EZH2,FGL2,FOXO1,FOXP3,GADD45G,HLA-A,HLA-DRA,IFI44,IFI44L,IL17A,IRF4,IRF8,LEF1,LGALS1,MID1,MS4A6A,MX1,PAPPA2,PRDM1,RPL22,RPS3,S100A10,SPP1,STAT5B,STAT6,TGFB1 | 1531 (21) |
| E2F3 | 2.30e-01 | transcription regulator | NA | -1.75e+00 | NA | 0.0e+00 | BAIAP2L1,CA12,CAV2,CCNA2,CCND1,CD9,CDCA4,CDK2,CDKN1A,COL18A1,DEK,E2F2,ECHDC2,EDN1,EZH2,FAM102A,FBLN5,FGF2,IGF1,INHBA,JAM2,LAMA4,LPL,MAL2,MCM7,mir-143,MYCN,NCAPG2,NECTIN1,PLK1,POLA1,POLA2,PPP1R13B,PTGER3,PTN,Raet1d/Raet1e,RBL1,SERPINE1,SERPINH1,THBD,THBS1,TNFAIP2,TP53BP2,XPO4 | 1344 (15) |
| pevonedistat | NA | chemical drug | NA | -1.75e+00 | NA | 2.0e-02 | ARG1,BCL2L1,BCL2L11,Ccl2,DLC1,ICAM1,IRS1,IRS2,OCLN,SELP,SLC1A5 | NA |
| diethylnitrosamine | NA | chemical toxicant | NA | -1.75e+00 | NA | 0.0e+00 | ACTA2,ANGPT2,ARG1,BCL2L1,BCL2L11,BIRC3,CASP3,CASP8,Ccl2,CCND1,CCND2,CD44,CDKN1A,COL3A1,CREB1,CREB5,CSTB,CXCL10,CXCL12,CYP7B1,E2F2,GLI1,GPC3,HGF,HIF1A,HOMER2,HRH2,LAMC2,LPL,MET,MKI67,Mt1,NFE2L2,PHLDA1,PROM1,QPCT,SELENBP1,SLC37A4,SLCO2B1,TEK,TGFB1,THY1,TIMP1,TRPV2 | 1314 (17) |
| okadaic acid | NA | chemical toxicant | NA | -1.76e+00 | NA | 4.0e-02 | ANXA1,BCL2L1,BCL2L11,BCL6,BDNF,CCND1,CCND2,CYBB,CYP1B1,EGR1,ELF1,ELN,FAM89B,GCH1,IL1RN,IRS1,JUND,KLF4,NR2F2,PTGS2,RXRA,SPP1,SRSF3 | NA |
| HK2 | 1.00e-02 | kinase | NA | -1.76e+00 | NA | 2.0e-02 | BCL2L1,CDH1,CDH2,SNAI1,SNAI2,TWIST1,VIM | NA |
| acetaldehyde | NA | chemical - endogenous mammalian | NA | -1.76e+00 | NA | 0.0e+00 | CNR1,COL1A1,DDR2,KLF9,MMP2,PPARG,SMOX,TGFB1,TIMP1 | 1274 (19) |
| NEUROG3 | NA | transcription regulator | NA | -1.76e+00 | bias | 2.0e-02 | ABCC8,ACSL1,CDH2,CDKN1A,DLL1,EBF1,ERBB3,FGFR1,HHEX,MAFA,MDK,NKX6-1,NOTCH2,NR2F1,NRP1,NTRK2,NTS,NUMBL,OR51E2,RORB,SEMA3A,SEMA3C,SLC26A7,SNAI2,SREBF1,SYP,ZBTB16 | NA |
| GPNMB | -1.18e+00 | enzyme | NA | -1.76e+00 | NA | 8.0e-02 | APCDD1,AXIN2,DDIT4L,ITGA5,MITF,NRP1,SNAI1,Tcf7 | NA |
| SMARCD3 | 1.16e+00 | transcription regulator | NA | -1.76e+00 | bias | 0.0e+00 | ALCAM,CD44,COL1A1,COL2A1,DEPTOR,FMOD,ITGA3,KLF4,MITF,PITX2,SOX6,WNT5A | 1249 (11) |
| CD69 | -1.20e-01 | transmembrane receptor | NA | -1.77e+00 | NA | 2.2e-01 | CCL24,CXCL10,IL17A,IL2RA,SOCS1,SOCS3,TGFB1 | NA |
| PCLAF | NA | other | NA | -1.77e+00 | NA | 0.0e+00 | BUB1,BUB1B,CCNA2,CDKN1A,CDKN2C,ECT2,ESPL1,GADD45G,KIF4A,KLF4,PLK1,TOP2A | 1016 (7) |
| MAP2K3 | 3.00e-01 | kinase | NA | -1.77e+00 | NA | 4.0e-02 | ACTA1,ATP2A2,CDKN1A,COL1A1,COL3A1,CTSK,CXCL10,ICAM1,ISG15,MAOB,MYH6,MYH7,PTGS2,RGS7,SERPINE1,SGK1,SLC1A3,STAT1 | NA |
| LUCAT1 | NA | other | NA | -1.77e+00 | NA | 5.0e-02 | CDKN1A,ERBB3,FN1,GLRX,IER3,ITGB4,NR4A2,PDK4,PTGS2 | NA |
| fluoride | NA | chemical - endogenous mammalian | NA | -1.77e+00 | NA | 0.0e+00 | ACTA2,ACTN2,Actn3,ACTN4,DKC1,EEF1A1,EZH2,GADD45A,GLI2,HDAC7,Hnrnpa3,HSPA1A/HSPA1B,HSPA2,MAPK3,MYH10,MYH6,MYH7,PLD2,PRKCQ,RPS15,RPS16,RPS3,RUNX2,TUBB4A,TUBB6,Ubb,VCAM1,VCP,YWHAQ | 583 (7) |
| SDCBP | -3.80e-01 | enzyme | NA | -1.77e+00 | NA | 0.0e+00 | CDH1,CLDN1,ITGA6,ITGB4,MMP2,PEBP1,RHOA,SNAI1,SNAI2,VIM | 1318 (21) |
| RABL6 | 2.30e-01 | other | NA | -1.77e+00 | NA | 0.0e+00 | BTG2,BUB1,BUB1B,CCNA2,CCNE2,CDK2,CENPF,CX3CL1,DAPK1,DRAM1,ELF4,EZH2,FEN1,KIF23,MCM7,NCAPG,PLK1,POLA1,PRC1,SERPINH1,SMAD6,TOP2A | 1245 (12) |
| mir-96 | NA | microRNA | NA | -1.77e+00 | NA | 3.0e-02 | CDH1,FN1,HERC6,IFI44L,IFIT1,IRS1,ISG15,NMI,RSAD2,RTP4,SLC39A9,SP110,VIM | NA |
| 2,3-bis(4-hydroxyphenyl)-propionitrile | NA | chemical reagent | NA | -1.77e+00 | NA | 2.8e-01 | ACTA1,BDNF,CCND1,CREM,GATA4,H6PD,HDAC4,INPP4B,INPP5F,SLIT3,USP19 | NA |
| THPO | NA | cytokine | NA | -1.77e+00 | NA | 0.0e+00 | BCL2L1,BIRC3,Bmyc,CCNA2,CCND1,CCND2,CD44,CISH,E2F2,EPSTI1,FLI1,Foxp1,GCH1,ICAM1,INHBA,IRF1,ISG15,ITGA2B,ITGB3,KDR,KLF4,MYCN,NFE2L2,NFKBIA,RARA,REL,RSAD2,RUNX1,SELP,SOCS3,STAT1,USP18 | 885 (17) |
| S1PR3 | -5.50e-01 | G-protein coupled receptor | NA | -1.78e+00 | NA | 0.0e+00 | ACTA2,Ccl2,CD44,ETS1,HGF,ICAM1,IGF1,PTGS2,SNAI2,TAGLN,VCAM1 | 939 (17) |
| BDNF | -2.21e+00 | growth factor | NA | -1.78e+00 | NA | 0.0e+00 | ACOT7,ADAM17,ADRB2,ANXA2,ANXA5,ATP2A1,ATP2A2,BCL2L1,BCL2L11,BDNF,BHLHE40,CAMK2A,CASP3,CASQ2,CAV2,CCND2,CD36,CDKN1A,CNR1,CP,CSPG4,CXCR4,CYGB,DPYSL3,DUSP1,DUSP6,EEF1D,EGR1,EGR2,EGR3,FLNA,FSCN1,FTL,GAP43,GDA,GFAP,GLUL,GNAI1,GRIA2,HOMER1,HSD17B12,HSD17B4,HSPA2,INHBB,KIF1A,KIF21B,KIF5A,KLC1,KLF10,KLF4,LGALS1,LOC728392,MACROD1,MAG,MAN2A1,MAP1B,MVD,MYCN,MYH3,MYH8,MYO5A,MYOD1,MYOG,NAB2,NCAM1,NCDN,NOS1,NPR1,NR4A1,NR4A3,NTRK2,PALD1,PDE1A,PENK,PFKFB3,PLP1,PLTP,PRKCZ,PRSS12,PVALB,RELN,RGS4,RHOA,RPL37A,RYR1,S100A10,SEMA3E,SERPINH1,SFRP1,SFRP2,SH3BGRL2,SLC16A7,SOSTDC1,SPARC,SPP1,SPRED2,SYP,TAGLN,TBC1D8,THBS1,TIPARP,TMEM45A,TNFRSF11B,TPH1,TRPC3,TUBA1A,Ubb,UCN,VASN,VIM,VSNL1,WNT2 | 1198 (19) |
| INHBB | -7.60e-01 | growth factor | NA | -1.78e+00 | NA | 0.0e+00 | COL3A1,HGF,MAFA,MAN2B2,NKX6-1,SERPINE1,SOSTDC1,SULF2,THBS1,THBS2,TIMP1,TNC | 1168 (16) |
| EREG | -3.00e-02 | growth factor | NA | -1.78e+00 | NA | 2.0e-02 | CALB1,FGF2,HAS2,PTGS2,TGFA,TNC,TNFAIP6 | NA |
| KLF1 | -4.00e-02 | transcription regulator | NA | -1.78e+00 | NA | 6.0e-02 | BCL11A,CD44,CDKN1A,CDKN2C,DMTN,E2F2,EPB42,FLI1,ITGA2B,KLF3,SERPINH1,SLC2A1,SPTB | NA |
| alitretinoin | NA | chemical drug | NA | -1.78e+00 | NA | 0.0e+00 | ABCA1,ABCC3,ABCG1,ADAM10,ANXA5,APOD,BCL2A1,BCL2L1,BMP3,CALB1,CASP1,Casp12,CCL24,Ccl6,CCND1,CD36,CD83,CD86,CDK2,CDKN1A,COX4I1,CXCL10,CXCL13,CYP4F2,DHRS9,DNASE1L3,DUSP1,FABP1,FN1,FOLR2,FOXP3,HLA-DRA,IL2RA,IL2RB,IRF1,ISG15,KLF5,MKI67,MYF5,MYH6,Naip1 (includes others),NR0B2,PLTP,PPARG,PTGIS,RARA,RARG,RXRA,RXRG,SFTPB,SLC27A1,SNAI1,SOAT1,SPP1,SREBF1,STRA6,TGFB1,UBA7,VIM | 1233 (19) |
| SULF2 | -9.90e-01 | enzyme | NA | -1.78e+00 | NA | 1.0e-02 | ADAMTS5,AXIN2,CCND1,COL2A1,GLI1,MMP2,PDGFB,SOCS3,TGFB1 | NA |
| arsenic | NA | chemical toxicant | NA | -1.78e+00 | NA | 2.5e-01 | BIRC3,FTL,GCLC,HIF1A,HSP90AA1,Mt1,TGFA | NA |
| HSPD1 | -1.90e-01 | enzyme | NA | -1.78e+00 | NA | 4.8e-01 | Ccl2,ICAM1,SELE,SOCS3,SREBF1,VCAM1 | NA |
| captopril | NA | chemical drug | NA | -1.78e+00 | NA | 0.0e+00 | A2M,Akr1b7,ANXA1,ASNS,BGN,CD44,CP,CSRP2,DLK1,F3,FBLIM1,GCGR,GNAI3,IER3,IGFBP6,IL1RN,LAMC2,LTBP2,MRC1,MYH6,MYH7,PTGS2,S100A10,S100A11,SERPING1,SPP1,TGFB1,THBS4,TIMP1,TMSB10/TMSB4X,Tpm1,TSPAN8 | 1388 (19) |
| Stat3-Stat3 | NA | complex | NA | -1.78e+00 | bias | 2.0e-02 | A2M,ARG1,BCL2L1,BIRC3,CCND1,CD36,CDKN1A,CRP,CXCL13,FTL,HIF1A,ICAM1,IL17A,LBP,SOCS3,WNT5A | NA |
| IQGAP1 | -7.90e-01 | other | NA | -1.78e+00 | NA | 4.0e-02 | CCND1,CDH1,CXCR4,IL17A,MET,NUAK2 | NA |
| CX3CL1 | -1.21e+00 | cytokine | NA | -1.78e+00 | NA | 0.0e+00 | ADAMTS1,APCDD1,APOD,ASPA,BCL2L1,BCL2L11,CCND1,CDK2,COL3A1,CPNE6,CSF1,CST7,CX3CL1,CX3CR1,CXCL12,ERBB3,ETV1,FGF2,FRZB,FZD2,GFAP,GNB3,GPNMB,HEY2,HIF1A,HPSE,ICAM1,ID2,IFI16,IGF1,LDLRAD3,LPAR1,MAP1B,MMP2,MSR1,N4BP3,PLP1,PPARG,PROM1,PYGM,RELN,RHPN2,SDK2,SELP,SEMA5A,SERPINF1,SPHK1,SPP1,SYP,TGFB1,TIMP1,WNT6 | 1477 (19) |
| VIM | -1.15e+00 | other | NA | -1.78e+00 | NA | 1.1e-01 | AXL,CDH1,F3,IL17A,ITGB4,SNAI2,TGFB1 | NA |
| IL12B | -2.00e-02 | cytokine | NA | -1.79e+00 | NA | 6.0e-02 | Ccl2,CCR5,CD86,CEBPD,CXCL10,DUSP5,GZMB,ICAM1,IL17A,INPP5D,SOCS1,SOCS3,STAT1,TGFB1,VCAM1 | NA |
| BCL2 | 1.50e-01 | transporter | NA | -1.79e+00 | NA | 3.0e-02 | AIF1,ATP2A2,BCL2L1,BCL2L11,CASP3,CCND1,CDKN1A,CKM,CLCN3,COL2A1,CTSH,ENO2,GADD45A,GAP43,GCLC,HIF1A,ICAM1,IGFBP6,IL17A,MMP2,NFKBIA,NSG2,PRDM1,RBL1,SPHK1,TIMP1 | NA |
| NOTCH4 | 7.30e-01 | transcription regulator | NA | -1.79e+00 | NA | 5.0e-02 | ACTA2,CD86,CNN1,HEY2,IL2RA,IRF1,PRAG1,SERPINE1,TAGLN,TEK | NA |
| TFAP4 | -3.50e-01 | transcription regulator | NA | -1.79e+00 | NA | 0.0e+00 | BCL2L1,CBFA2T3,CD44,CDH1,CDH2,CDK2,CDKN1A,CLDN1,CXCL14,EGR1,ESRP2,ETV1,FN1,GLI2,IRF6,LEF1,LGR5,OCLN,PKP3,SNAI1,TAF1C,VIM | 1078 (7) |
| phenylephrine | NA | chemical drug | NA | -1.79e+00 | NA | 0.0e+00 | ACTA1,ANKRD1,ATP2A2,COL3A1,DUSP1,EDN1,EDNRB,EGR1,Esrra,FHL1,GATA4,GCLC,MAP1LC3A,MB,MSTN,MTSS1,MYH6,MYH7,MYL1,NDUFV1,NFE2L2,PDK4,PLAGL1,PRKCB,PTGS2,RAPH1,RGS2,RGS4,RRAD,SLC9A1 | 1085 (23) |
| dithiothreitol | NA | chemical reagent | NA | -1.79e+00 | NA | 1.0e-02 | ATF3,ATP2A2,CCND1,ERO1B,GADD45A,HIF1A,NR0B2,PHLDA1,SELE,TLR2,UBE3A | 1158 (17) |
| taurocholic acid | NA | chemical - endogenous mammalian | NA | -1.79e+00 | NA | 5.0e-02 | ATF3,Ccl2,CYP27A1,EGR1,GADD45B,KDR,NR0B2,PTGS2,TP63 | NA |
| nitrofurantoin | NA | chemical drug | NA | -1.80e+00 | NA | 0.0e+00 | A2M,ACTG1,ADAMTS1,AMD1,ANXA2,ANXA5,ASNS,BCL2L1,BTG2,C3,C4BPA,CASP3,CCND1,CFI,COL2A1,CP,CRP,CTSS,CXCL10,EEF1A1,FABP1,GADD45A,GCGR,GPNMB,GSR,HSD17B4,IER3,IGF1,ITGB4,KRT19,LBP,LCAT,LOX,MAPK3,MET,MMP14,Mt1,NFKBIA,PLAT,PRDX1,PRKCB,RPL6,RPS6KB1,S100A10,S100A11,SDC1,SELENBP1,SELENOP,SPP1,STMN1,TIMP1,TUBA1A,TUBB,TYMS,VCAM1 | NA |
| PPP3CA | 6.10e-01 | phosphatase | NA | -1.80e+00 | NA | 0.0e+00 | ACTA1,ALOX12,ATP2A2,C3,CD9,CDH2,CDKN1A,CKM,CRYAB,CSRP1,FN1,FTL,GFAP,LAMP2,LCAT,LITAF,LPAR1,MAOB,MGST1,mir-133,MYOG,NFATC3,PDK2,PDPN,PLD1,PLPP3,PMP22,PRDX5,PTGFR,PTGS2,RUNX2,S100A4,S100B,SDC4,SNAI1,SPP1,TNNI1,VIM | 1532 (24) |
| L-arginine | NA | chemical - endogenous mammalian | NA | -1.80e+00 | NA | 1.7e-01 | BGN,ELAVL1,FN1,IGF1,MYH3,SERPINE1,SLC2A1,TGFB1,UTRN | NA |
| mirdametinib | NA | chemical drug | NA | -1.80e+00 | NA | 0.0e+00 | ABCA1,BCL2L11,CHKA,DDIT4,DEPTOR,ERCC1,ESRRB,ETV1,KLF4,MRC1,TBX3,TFCP2L1,TGFB1,TNFRSF10A,TYRO3,VCAM1 | 1173 (12) |
| COL1A1 | -1.60e+00 | other | NA | -1.80e+00 | NA | 0.0e+00 | CDKN1A,CLIC4,COL1A1,CXCR4,EDN1,ICAM1,MMP14,SELE,SNAI1,VCAM1 | 1241 (21) |
| PF4 | -8.00e-02 | cytokine | NA | -1.80e+00 | NA | 0.0e+00 | ACTA2,BIRC3,Bmyc,CD83,CD86,CDKN1A,CNN1,E2F2,EPSTI1,F3,FLI1,FN1,Foxp1,GCH1,ICAM1,IL17A,IL1RN,INHBA,IRF1,ISG15,KLF4,LY75,MYCN,NFE2L2,NFKBIA,RARA,REL,RSAD2,SPHK1,STAT1,TGFB1,THBD,USP18 | 1036 (15) |
| IL7 | -1.65e+00 | cytokine | NA | -1.80e+00 | NA | 0.0e+00 | AHR,BCL2L1,BCL2L11,CASP3,Ccl2,CCND2,CD86,CDK6,CDKN1A,CEACAM1,CISH,COL1A1,CSF1,CTSK,CXCR4,DPP4,DUSP5,E2F2,EBF1,FLT3LG,FN1,FOXO1,FOXP3,GSR,IL17A,IL18R1,IL1R1,IL2RA,IL7,ITGB7,JAK3,LEF1,LYN,MAF,MX1,NTN1,RUNX2,SLC2A1,SMAD7,SOCS1,SOCS3,Tcf7,TNFSF8 | 1273 (16) |
| HOXA11-AS | NA | other | NA | -1.81e+00 | NA | 1.0e-02 | CASP3,CDH1,CDH2,CDKN1A,SNAI1,SNAI2,ZEB2 | 1508 (24) |
| H2AB3 (includes others) | NA | other | NA | -1.81e+00 | bias | 2.0e-02 | ATF3,BCL2L11,CDKN1A,CHAC1,CSRP3,DHRS9,HIP1R,IGFN1,IRF3,JAK3,LMO1,PAQR9,SERPINB9,SLC29A3,TNFRSF8 | NA |
| urethane | NA | chemical toxicant | NA | -1.81e+00 | NA | 2.8e-01 | ARG1,CCND1,CDKN1A,KDR,PTGES,PTGS2,SFRP1 | NA |
| NGF | -9.50e-01 | growth factor | NA | -1.81e+00 | NA | 0.0e+00 | A2M,ACER2,AGL,ANXA2,ASIC2,ATF3,AXIN2,BAMBI,BCL2L1,BCL2L11,BDNF,BTG2,CAV1,CAV2,CCND1,CD83,CD86,CDH1,CDK2,CDK5R1,CDKN1A,CITED2,CRYAB,DUSP1,DUSP6,E2F2,EEF1A1,EGR1,EGR2,EHD4,EPHA4,ERRFI1,ETV5,GADD45A,GADD45G,GAP43,GCH1,GRIA2,IER3,ITGA1,ITGA2,KLF4,MACROD1,MAP2,MAPK14,MMP2,MYCN,NAB2,NKD1,NOS1,NR4A1,P2RX2,PLA2G4A,PLK2,PLK3,PLK4,PNMT,PPARG,PPP2R2B,PRKAR2B,RET,RGS4,S1PR2,SDC2,SEMA6D,SHTN1,SLC41A2,SORT1,STMN4,TGFB1,TRPV1,TRPV4,UNC5C,VEGFC,WNT4,WNT5A,ZFP36 | 1920 (19) |
| MED1 | 5.10e-01 | transcription regulator | NA | -1.82e+00 | NA | 0.0e+00 | ADIPOQ,AGPAT2,ANO2,ATP10D,BCL11A,BCL2L1,BCL3,BCL6,BHLHE40,BOP1,CCND1,CCND2,CDK2,CDKN1A,CREB5,DIO1,E2F5,EBF1,EDF1,EML1,EPHA3,ERMP1,ESRRB,FADS2,FAM89B,FGD2,FOXO1,Foxp1,GADD45A,GPAM,HAS2,HDAC7,HECW2,HSD17B12,HSD17B4,ID2,IGF1,IL2RB,IRF4,IRF8,KLF4,KLF5,LAD1,LEF1,MAD1L1,MB,MET,MPP7,MYCN,MYH7,MYOD1,NFKBIA,OLR1,PDK4,PLIN1,PLK1,POLE4,PPARG,PRDM1,PRR5L,SALL4,SLC27A1,SLC39A8,TBX3,Tcf7,THBS1,TNNC1,TNNI1,TNNT1,UNC5D | 1350 (20) |
| MMP11 | NA | peptidase | NA | -1.82e+00 | NA | 9.0e-02 | CD36,HSPE1,LDHB,PSMB1,PTGS2,SLC16A1,SLC16A3 | NA |
| IGF2BP1 | NA | translation regulator | NA | -1.82e+00 | NA | 0.0e+00 | AXIN2,BCL11A,CD44,CDC34,CDKN1A,COL14A1,COL1A1,COL5A1,COL6A3,GADD45A,GLI1,LGALS1,LUM,OCLN,SERPINH1,TNC | 1233 (14) |
| MYOF | -1.27e+00 | other | NA | -1.82e+00 | NA | 2.0e-02 | ADIPOQ,Ccl2,KDR,NFATC3,NFATC4,PPARG | NA |
| PTK2 | 2.80e-01 | kinase | NA | -1.82e+00 | NA | 0.0e+00 | ACTA1,ACTA2,BIRC3,Ccl2,CCND1,CDKN1A,COL1A1,CSPG4,FN1,GATA4,IRS1,ITGA5,MMP2,MYH6,MYH7,OCLN,PALLD,PCOLCE2,SKP2,SNAI1,SPP1,THBS1,TIMP1,TLL1,TNC,VCAM1 | 1357 (20) |
| S-nitroso-N-acetyl-DL-penicillamine | NA | chemical reagent | NA | -1.82e+00 | NA | 2.0e-02 | CDKN1A,CXCL12,GRIA2,HIF1A,HSPA1A/HSPA1B,MARCKSL1,MB,NPR2,PPARD,PRDM1,PTGS2,S100A10,SLC2A1,SPP1,SUMO2,TGFB1,TIMP1 | NA |
| bexarotene | NA | chemical drug | NA | -1.83e+00 | NA | 0.0e+00 | ABCA1,ADD3,ADRB2,ALCAM,ANAPC11,ASNS,AXL,BCL11B,Ccl2,CCND1,CLIC6,CPLX1,CTSH,DACH1,DDIT4,DLK1,DUSP1,DUSP5,EFNA5,EGR3,GFAP,GRIN3A,Gsta4,GUK1,HERPUD1,ICAM1,IGFBP6,IL2RA,IL2RB,ITM2A,KLF10,LOXL2,LPL,LSM4,MAF,MAFF,MRPL54,MTHFD2,MYOD1,MYOG,NOS1,NR4A2,NRP2,NTRK2,NTS,PIK3R1,PLAT,PLOD2,PPARG,PTGS2,PTPRO,RABAC1,RET,RORB,RTN4R,SELENOM,SIAH2,SLC18A2,SLC27A1,SLC7A1,SPARC,SYP,TGFA,TGFB1,TM4SF1,TPGS1,UAP1,UQCC3,VCAM1 | 1571 (20) |
| AREG | -4.90e-01 | growth factor | NA | -1.83e+00 | NA | 0.0e+00 | BCL2L1,C3,CCNA2,CCND1,CDH11,CENPF,CXCR4,EGR1,FGF10,FOXP3,H2AC18/H2AC19,HAS2,HCAR2,IQGAP3,MKI67,MMP15,PLK1,PRC1,PTAFR,PTGS2,PTX3,RUNX1,SLC36A1,SSBP1,TNFAIP6,TOP2A | 1514 (19) |
| SMOC2 | -8.00e-02 | other | NA | -1.83e+00 | NA | 0.0e+00 | ACTA2,CDH1,CENPF,FN1,LGR5,SNAI1,VIM | NA |
| DNMT3A | -4.70e-01 | enzyme | NA | -1.83e+00 | NA | 0.0e+00 | ACSL1,ACTA1,ACTC1,ADAMTS9,ADCY7,AKAP12,Akap17b,APLN,ATF3,ATP2B4,BCL2L11,BRCA2,BTK,CAMK2A,CASQ2,CDH1,CKM,CNR1,CSF1R,CXCR4,CYBB,CYSLTR1,E2F2,ETV5,FCER1G,FGF2,FOXO1,FOXP3,HDAC4,IGFBP5,IL17A,IL18R1,IRF1,IRF5,IRF8,IRS1,KCNA1,Mt1,MYH6,MYH7,MYH7B,MYL2,MYL3,NFATC3,NR4A1,P2RY1,PCBP4,PDE1A,PDE1C,PIK3C2B,PIK3CG,PLA2G7,PLK1,PLK2,PPP1R3A,PPP1R3C,PRKAR2B,PRKCB,PRKCI,PTGS2,PTPRC,RCAN2,RGMA,RUNX2,SDC4,SERPINH1,SLIT3,SNRPN,SOCS3,SPARC,SPHK1,SPP1,ST14,SYK,Tcf7,TGFB1,TLR4,TLR5,TLR7,TNNC1,TNNI1,TNNT2,TWIST1 | 1615 (24) |
| dactolisib | NA | chemical drug | NA | -1.84e+00 | NA | 0.0e+00 | AK4,ALDH9A1,BCL2L11,BPGM,CDH1,CDKN1A,CITED2,DDIT4,DEPDC1,EIF4EBP1,ERBB3,FAM162A,GAPDH,GPI,HK1,HOMER1,IL2RA,MAP1LC3B,PC,PGK1,PGM1,PKM,PLOD2,SAP30,SDC2,SKP2,SLC16A3,SNAI1,TGFA,TPBG | 1386 (23) |
| 5-hydroxytryptamine | NA | chemical - endogenous mammalian | NA | -1.84e+00 | NA | 0.0e+00 | APBB1IP,ASIC2,BDNF,BIN1,Calm1 (includes others),CDH1,CDH2,CFL1,COL23A1,CYBB,CYP1B1,DUOX2,EGR1,EIF4EBP1,F2R,F3,FADD,FGF2,FN1,GAD1,GPR183,HIF1A,HTR2B,ICAM1,IGF1,IL17A,ITGA2B,MAPK3,MYL2,NCF2,NR4A1,PFN1,PKN1,PLIN3,PTGS2,RAB8A,RABAC1,RUNX2,SEMA6B,SERPINE1,STX4,TGFB1,THBS1,TRPV1,TUBA8,TUBB,UCP3,VCAM1,VIM,VTI1A | 1296 (23) |
| HOXC6 | 8.00e-02 | transcription regulator | NA | -1.85e+00 | NA | 0.0e+00 | CASP1,COL23A1,DCN,ERRFI1,GAS2L3,MME,PDGFRA,PLXDC1,RUNX1,SH3D19,SIPA1L1,SLC1A3,SLC44A1,TNFAIP8,VCAM1,ZBTB7C,ZNF536 | NA |
| IL-1R | NA | group | NA | -1.85e+00 | bias | 2.0e-02 | CASP8,COL3A1,FGF2,HGF,ICAM1,IGFBP4,IL17A,IL7,MMP14,S100B,SELE,SERPINE1,SMAD6,TIMP1,TNFRSF11B,TNFRSF1B | NA |
| S100A8 | -1.40e-01 | other | NA | -1.85e+00 | NA | 0.0e+00 | A2M,ABCG1,ADAMTS1,ADAMTS5,AKAP12,ALDH1A1,APLN,ATF3,BCL2L1,BCL3,BHLHE40,CASP1,Ccl2,Ccl7,CCND1,CCNE2,CDH3,CORO1A,COX6A2,CP,CSF2RB,CSTF1,CXCL10,CXCL14,DDIT4,ELN,EPB41L4B,ETV5,FBLIM1,GJB2,GPR37L1,GZMB,HEY2,ICAM1,IGF1,IL1RL1,IL33,ISG15,ITGB4,KLF15,LTBP1,MAG,MMP14,MMP2,MYCT1,MYH8,NFKBIA,NR4A3,OLR1,PDGFC,PER1,PHLDA1,PLK3,PLXNB3,PRSS12,PTGES,PTPRO,ROBO2,RXRG,SCUBE1,SEMA3B,SGK1,SIX1,SOCS3,SOCS7,TNFAIP8,TUBA8,UNC5A,USP18,VCAM1,VCAN | 1307 (12) |
| TNFSF10 | -5.20e-01 | cytokine | NA | -1.85e+00 | NA | 0.0e+00 | ADRB2,ANGPT2,BCL2L1,BIRC3,CASP3,CASP8,CD28,CXCR4,DDIT4,DPYD,FADD,FOXP3,HLA-A,IFI16,IFIT1,IL17A,IL17RD,IL1RN,IL2RA,ISG15,MMP2,NFKBIA,NR2F1,ODF3L1,PER1,PRKCE,PTGS2,PTPRC,SELE,SERPINH1,SLC2A1,STAT1,TIMP1,TNFAIP2,TNFRSF10A,TNK2,TP63 | 906 (11) |
| IL11 | 9.00e-02 | cytokine | NA | -1.85e+00 | NA | 0.0e+00 | A2M,ACTA2,ANXA2,BCL2A1,BCL2L1,CEBPD,COL2A1,CRP,DLK1,DUSP6,EZR,ICAM1,IGF1,IGFBP5,IRF1,LBP,MMP2,PAPPA2,PDPN,PPARG,SFTPB,SMAD6,SOCS3,SPHK1,SPP1,STX11,TIMP1,VCAM1,VWF,WNT5A | 1082 (17) |
| cis-urocanic acid | NA | chemical drug | NA | -1.85e+00 | bias | 0.0e+00 | ADAMTS1,CLDN1,CRYAB,GADD45B,GLRX,HSPA1A/HSPA1B,KCNK1,NCF2,PTGS2,TMOD3 | NA |
| AVP | -3.00e-02 | other | NA | -1.86e+00 | NA | 1.0e-02 | ACTA2,APLN,ATF3,ATP1A1,CCND1,CKM,COL3A1,EDNRB,EGR1,MYF5,MYOG,NOS1,RUNX2,S100A6,SCNN1G,TGFB1 | 1210 (18) |
| imiquimod | NA | chemical drug | NA | -1.86e+00 | NA | 0.0e+00 | A3GALT2,AQP4,Bmyc,BTG2,BTRC,CA9,CCDC124,Ccl2,CD86,CTSS,CXCL10,ECH1,FHL3,FLI1,FSCN1,GATA4,GLI1,HCK,ICAM1,IFITM3,IL17A,IL1RN,IL2RA,ISG15,ITGB2,LBX1,LDHB,LRG1,MID1,MITF,MX1,NAB2,NCAPG,NNMT,OASL,PLTP,PNPLA7,PPP1R3B,PRKAB1,PTGS2,RNF213,RNF7,RSAD2,SMYD2,SOCS1,SOCS3,STAT1,TCEAL7,TGFB1,TLR7,TMEM259,TRPM4,TTLL11,UBAC1,UBC,XAB2,XPA,Zfp429 (includes others) | 953 (17) |
| TNFRSF1A | -5.70e-01 | transmembrane receptor | NA | -1.86e+00 | NA | 0.0e+00 | ABCC3,ABCC5,ABCG4,ANGPT2,BCL2L1,BDNF,BIRC3,CASP3,Ccl2,CCNE2,CD36,CD44,CD83,CD86,CDH2,CDKN1A,CLCN3,CLMP,CXCL10,CXCL13,E2F8,GFAP,ICAM1,IER3,IGF1,IL17A,KDR,KNTC1,LBP,LGALS9B,LMO2,MMP14,MMP2,MYOD1,NFE2L2,Podxl,PPARD,RGS7,SELE,SELP,SERPINE1,Slco1a4,SOCS3,SOX6,SS18L2,TGFA,TGFB1,THBD,TLR4,TMCC2,VCAM1 | 1094 (14) |
| GDF9 | 3.00e-02 | growth factor | NA | -1.86e+00 | NA | 0.0e+00 | GREM1,HAS2,ID2,INHA,INHBA,INHBB,ITGA6,KIT,KITLG,LOX,PTGS2,PTX3,SMAD6,SMAD7,STAR,TNFAIP6,VCAN | 1142 (23) |
| KDM6B | -8.00e-02 | enzyme | NA | -1.86e+00 | NA | 0.0e+00 | CDH1,CDH2,FN1,GBP7,ITGA2B,ITGAL,OASL,Oasl2,PPIA,SNAI1,SNAI2,TP63,VIM | 1410 (21) |
| CSHL1 | NA | growth factor | NA | -1.87e+00 | NA | 9.0e-02 | ACTA1,ACTA2,BCL6,CA3,CISH,CUX2,IGF1,IRF1,PIK3R1,SERPINH1,SLC2A1,SOCS3,STAT5B,TOX,Trim24 | NA |
| HDAC6 | -3.40e-01 | transcription regulator | NA | -1.87e+00 | NA | 0.0e+00 | ADAMTS1,CDH1,COL1A1,GDF6,HIF1A,ICAM1,IGF1,LTBP2,PDGFB,SERPINE1,TAGLN,TGFB1,TGFB1I1,TGFBI,VCAM1,VIM | 1566 (20) |
| MIA | -1.03e+00 | other | NA | -1.88e+00 | NA | 0.0e+00 | CDH1,CDH2,FN1,ITGB3,MIA,MMP14,PLAT,SPARC | NA |
| HMGB2 | NA | transcription regulator | NA | -1.88e+00 | NA | 0.0e+00 | ADIPOQ,CCND1,CD36,COL2A1,FZD2,INHBA,IRS1,LPL,MMP14,PHLDA1,PPARG,RETN,RUNX2,VEGFC | 1685 (20) |
| L-triiodothyronine | NA | chemical - endogenous mammalian | NA | -1.88e+00 | NA | 0.0e+00 | A2M,AATK,ABCA1,ACOT11,ACSL1,ACTA1,ACTC1,ACTG2,ADAMTS5,ADIPOQ,ADRB2,ALDH1A1,AMD1,ATP1A1,ATP1B1,ATP1B2,ATP2A2,ATP8B4,BCL2L1,BCL2L11,BCL3,BDNF,BMP4,BTG2,CASP3,Ccl6,CCND1,CD36,CD44,CDC42EP4,CDCA4,CDK2,CDKN1A,CMKLR1,CNR1,COQ10B,COX4I1,CTSH,CXCL12,CXCL14,CYP26B1,D1Pas1,DAB2IP,DBP,DIO1,DLK1,DUSP1,DUSP5,DVL1,EBP,EDN1,EDN3,EGF,EGR1,EGR2,ENG,ENO2,F3,FABP1,FGFR1,FKBP10,FKBP7,FNDC5,FOLR2,G6PD,GBP4,GLDN,GLI2,GPCPD1,GPD2,H2-T22,H2AC18/H2AC19,H6PD,HBA1/HBA2,HIF1A,HINT1,HLF,HOMER1,ID2,IDH3A,IGF1,IGFBP4,IGFBP6,IL4I1,INHA,ITGB3,KCNK1,KLF9,Ldha/RGD1562690,LSS,MAFA,MAMDC2,Mbp,MC4R,mir-133,MMP14,MSMO1,MVD,MYBPH,MYH6,MYH7,MYL2,MYOD1,MYOM3,NCOR2,NID1,NR4A1,NR5A2,NTRK2,NUDT18,OXTR,PAQR6,PDK2,PDK4,PER1,PFKFB4,PGK1,PITX2,PITX3,PLA2G2A,Pmaip1,PNPLA3,PPARG,PPARGC1B,PRDM16,PRKCQ,PRKCZ,PRR16,PTAFR,PTGIS,PTGS2,PYGL,RAB30,RARA,RARRES1,RASD2,RASGRP1,RBL1,RCAN2,RELN,RET,RGN,RGS2,ROCK1,RUNX2,Scd2,SEMA7A,SERPINE1,SFRP2,SLAMF9,SLC16A2,SLC18A2,SLC25A45,SLC27A1,SLC2A1,SLC35G1,SLC46A3,SLC9A1,SMAD7,SREBF1,ST6GAL1,STAR,TGFB1,TMPRSS2,Tpi1 (includes others),TRHDE,TSHR,TSKU,UCP3,UMPS,WIPF3,WNT4 | 1600 (21) |
| emactuzumab | NA | biologic drug | NA | -1.89e+00 | bias | 0.0e+00 | DHX58,GBP4,IFIT1,IFITM3,ISG15,SOCS1,STAT1 | NA |
| COMMD1 | 2.40e-01 | transporter | NA | -1.89e+00 | bias | 0.0e+00 | ALDOA,BIRC3,DDIT4,EGLN1,GRHPR,KRT19,NFKBIA,PFKFB3,PGK1,STAT1 | 1141 (12) |
| superoxide | NA | chemical - endogenous mammalian | NA | -1.89e+00 | NA | 1.0e-02 | CAV1,CYBA,FN1,ICAM1,MARCKSL1,PTGS2,TIMP1,TLR8 | 1322 (17) |
| STS | 5.60e-01 | enzyme | NA | -1.89e+00 | NA | 1.0e-02 | ADGRE1,ADIPOQ,Ccl2,CEBPD,EEF1A2,HSPA1A/HSPA1B,IGF1,IRS1,Mt1,PNPLA2,PPARG | 1188 (18) |
| 3-deoxy-2-octulosonic acid(2)-lipid A | NA | chemical - endogenous non-mammalian | NA | -1.89e+00 | NA | 1.0e-02 | Ccl2,CXCL10,DHCR7,LSS,PTGES,PTGS2,SOAT1 | NA |
| hydroxyurea | NA | chemical drug | NA | -1.89e+00 | NA | 2.5e-01 | CCNA2,CCND1,CCND2,CDKN1A,E2F2,EDN1,GADD45A,IFIT1,KLF4,LGALS12,MCM7,MX1,NMI,OASL,PDE4A,POLA2,PRDM1,SELE,STAT1,UHRF1,WEE1 | NA |
| CCN1 | NA | other | NA | -1.89e+00 | NA | 0.0e+00 | BCL2L1,BCL2L11,C3,Ccl2,Ccl7,CCND1,CCND2,CDKN1A,COL1A1,CXCL10,DVL1,FCER1G,FN1,HIF1A,IL10RB,ITGA2,ITGA3,ITGA5,ITGB3,KDR,MMP2,NOX1,NR4A1,PTGS2,SERPINE1,SFRP1,TGFB1,TIMP1,TLE1,TLR4,TLR7,VEGFC,WNT5A | 1277 (16) |
| arsenite | NA | chemical toxicant | NA | -1.90e+00 | NA | 0.0e+00 | AHR,CAV1,CCND1,CDH1,CDH2,CDK14,CDKN1A,CELF2,COL8A1,CYP1B1,DHRS1,DUSP1,EGR1,FZD1,GADD45A,GCLC,HAS2,HGF,HS6ST2,HSPA1A/HSPA1B,IER3,IGF1,IKBKB,INHBA,INHBB,IRF1,MAFF,NFE2L2,NR4A1,PLCB1,PPP1R3C,PRKD1,PRKDC,PTGS2,SEMA5A,SERPINE1,SFRP4,SLC38A2,SNAI2,TGFB1,THBS1,UGDH,VEGFD | 1345 (17) |
| SLC22A5 | -7.80e-01 | transporter | NA | -1.90e+00 | NA | 2.0e-02 | ACADL,ACVRL1,BMP4,CDKN1A,COL3A1,ITGB7,LTBP1,STAT1,TGFB1,TGFBI | NA |
| HDAC4 | 7.00e-01 | transcription regulator | NA | -1.90e+00 | NA | 0.0e+00 | ACTA1,ACTA2,ATF3,BDNF,CALB1,CAMK2A,CCND1,CDKN1A,CHRDL1,CKM,CNKSR2,CSRP3,EGR2,GADD45A,GPM6A,HDAC4,HDAC9,HIF1A,HLA-DRA,HOMER1,HOMER2,IFITM3,ISG15,KLHL2,LDB2,LGI1,MAG,MMP2,MPZ,MYBPC2,MYH10,MYLK2,MYOG,MYOM2,MYOZ1,NR4A1,NR4A2,NRCAM,NTM,Pcp4l1,PMP22,PPP3CA,PRKCB,PRX,PTGS2,RGS2,RGS4,RGS7,RSAD2,RUNX2,SLC2A1,TAGLN,TRPV1,VCAM1 | 1149 (21) |
| CD24 | NA | other | NA | -1.90e+00 | NA | 0.0e+00 | ADD3,ADRB2,ATF3,CAV1,CDKN1A,CHAC1,DEPDC1,DEPDC1B,DUSP5,ECM1,EDEM3,EMP3,EPHB6,HOMER3,ICAM1,KIF18A,KNTC1,LAT2,MBNL1,N4BP3,NAGK,OASL,PDGFB,PLCB1,RARRES1,RNF25,RSBN1,SLC4A4,SPHK1,TFPI2,THBS1,TOP2A | 1333 (19) |
| NR1I3 | -9.00e-02 | ligand-dependent nuclear receptor | NA | -1.91e+00 | NA | 1.0e-02 | ABCC3,ABCC4,AHR,ALDH1A1,CDKN1A,CYP27A1,CYP39A1,CYP7B1,DIO1,EIF4EBP1,EPHX1,FAM107B,GADD45B,Gsta4,HK1,HSD17B4,ICAM1,IL1R1,LRG1,MAFF,Mt1,NEDD9,PDE3B,RARRES1,Slco1a4,SREBF1,TMPRSS2,TNFAIP2 | NA |
| IL1R1 | -1.24e+00 | transmembrane receptor | NA | -1.91e+00 | NA | 0.0e+00 | ABCC3,ABCC5,ACTA2,Ccl2,Ccl7,CXCL10,CXCL12,EGR1,FAM89B,GFAP,ICAM1,IGF1,IL17A,LBP,MMP2,PTGS2,S100B,SELE,Slco1a4,TGFB1,TIMP1 | 887 (15) |
| testosterone propionate | NA | chemical drug | NA | -1.91e+00 | NA | 1.0e-01 | CLTB,DMBT1,FBXO32,IRS1,NOS1,OXTR,PARM1,SKP2,SLC26A3,SPDEF,TGFB1,TRIM63 | NA |
| CGAS | NA | enzyme | NA | -1.91e+00 | bias | 1.0e-02 | ARG1,CASP3,CDKN1A,CXCL10,IFI44,IFI44L,IFIT1,ISG15,MAP1LC3B,OAS3,OASL,RSAD2,USP18 | NA |
| SGK1 | 7.00e-01 | kinase | NA | -1.91e+00 | NA | 7.0e-02 | BCL2L11,CDK6,CDKN1A,KCNA1,KCNA2,KCNA5,KCNQ2,PPARG,SCN5A,SCNN1G,SLC1A1,SLC1A3,SLC1A5,SLC38A3,SLC9A3,SMO | NA |
| PAX3 | -1.52e+00 | transcription regulator | NA | -1.91e+00 | NA | 0.0e+00 | ANXA1,ARHGDIB,ASNS,ATN1,ATP2B4,BCL2L1,BMP4,CDH3,CDKN1A,CNR1,CXCR4,CYP1B1,DBN1,DNM1,EGR2,EYA2,F2RL1,F3,FGF9,FHL1,FUBP1,G0S2,G6PD,ID2,ID4,IRS1,LBX1,LRRC17,MEOX1,MET,MICB,MITF,MYL2,MYOD1,MYOG,NEDD9,NNMT,OLFM1,PAX3,PEA15,PHGDH,PPIB,PTGER3,PTPN12,PTPN3,PXDN,RAB11B,RAB31,RASSF2,RET,SHMT1,SIX1,SLA,SNCA,SOX10,SREBF1,SRSF3,ST8SIA2,STX3,TEK,TFPI2,TNC,TNNI1,TYRO3,VCAN,ZFP36L2 | 1220 (12) |
| Fibrinogen | NA | complex | NA | -1.91e+00 | NA | 2.0e-02 | BCL3,Ccl2,F3,FCGR3A/FCGR3B,ICAM1,MMP14,SELP,TLR2 | NA |
| PLAUR | -4.70e-01 | transmembrane receptor | NA | -1.91e+00 | NA | 0.0e+00 | ACTA2,BCL2L1,C5AR1,Ccl2,CCND1,CDH1,CDH2,CYBB,EIF2AK3,ITGA6,KDR,MMP2,PRKDC,SNAI1,SOCS1,VIM | 1107 (17) |
| FAAH | -1.20e+00 | enzyme | NA | -1.91e+00 | NA | 1.9e-01 | CTSK,FAAH,PLD1,RPL17,RPL7L1,RPS18,RPS2,SLC22A17 | NA |
| jasminoidin | NA | chemical drug | NA | -1.91e+00 | bias | 0.0e+00 | EGF,IGFBP5,KCNJ13,LCAT,MDK,MGST1,PC,TAGLN,VIPR2 | NA |
| CHEK1 | NA | kinase | NA | -1.91e+00 | NA | 5.0e-02 | BCL2L1,BCL2L11,BUB1,BUB1B,CDC25B,CDKN1A,MICB | NA |
| Map3k7 | NA | kinase | NA | -1.92e+00 | NA | 0.0e+00 | BCL2L1,BHLHE40,BMP4,CASP3,Ccl2,Ccl7,CXCL10,EDN1,EGR2,FGF10,FGL2,HAS2,ID4,IL15RA,ISG15,MVK,NFKBIA,NOD2,OSR1,PROM1,PTGS2,RILPL1,RSAD2,RUNX1T1,SESN1,SNAI1,SPHK1,VCAM1,WNT11 | 984 (10) |
| HEIH | NA | other | NA | -1.92e+00 | bias | 0.0e+00 | BCL2L1,CACNB2,DUSP1,FGF10,FGF2,FGFR1,FLNA,GADD45B,HSPA2,IGF1,KITLG,NTRK2,PDGFC,STMN1 | 627 (7) |
| carbonyl cyanide m-chlorophenyl hydrazone | NA | chemical toxicant | NA | -1.92e+00 | NA | 0.0e+00 | CLDN1,DDIT4,DUSP5,ERRFI1,ESM1,GNG11,IRF3,MAP1LC3B,MYCT1,NLRP3,OLAH,PHLDA1,PTGS2,RND3,SELP,SERPINE1,TGFB1,TM6SF1,ZFP36L1 | 999 (17) |
| LPA | NA | other | NA | -1.92e+00 | NA | 3.0e-02 | ICAM1,SELE,SERPINE1,VCAM1 | NA |
| GATA1 | NA | transcription regulator | NA | -1.93e+00 | NA | 0.0e+00 | ABCC4,ALOX12,ALOX5,ANGPT2,ANK1,ARHGAP4,BCL2L1,BCL2L11,BLVRB,BTG2,CBFA2T3,CCND1,CCND2,CCR1,CCR3,CCR5,CD36,CDK2,CDK6,CDKN1A,CDKN2C,CIITA,CMA1,CNN3,CPA3,CREM,CYBB,DMTN,EGR1,EPB42,ETS1,EZH2,FHL1,FLI1,Foxp1,GNAS,GP1BB,HBA1/HBA2,HHEX,HPSE,HSF2,IL1RL1,INHA,INHBB,IRF8,ITGA2B,ITGA6,ITGB3,JAZF1,KDR,KIT,LEPR,LMO2,MAMDC2,MGST2,MITF,MS4A2,MYCN,NAB2,NCOA7,NFIL3,NHP2,NOP2,NR4A2,NRARP,PAPPA2,PLEK,Podxl,POLA2,PSTPIP2,PTPN6,RANBP1,RBL1,REL,RPL22,RPS11,RUNX2,SELP,SLC38A9,SNCA,SOX6,SP140,SPTB,SSBP3,ST3GAL6,TAL1,Tcf7,TEK,TFDP2,TGFB1I1,TOP2A,Tpm1,UAP1,UHRF1,UMPS,USP16,VWF | 1481 (23) |
| TGFBR | NA | group | NA | -1.93e+00 | NA | 0.0e+00 | ACTA2,ADAM10,ADAMTS1,CD44,CDH11,NOX1,NOX4,SNAI1,SOCS3,WNT5A | 1245 (21) |
| EP400 | -2.50e-01 | other | NA | -1.93e+00 | NA | 0.0e+00 | AGPAT2,CCNA2,CDKN1A,CENPF,E2F2,E2F7,E2F8,NCAPG2,PLK1,PPARG,RBL1,SGO1,SKA1,SKP2,UHRF1 | 417 (7) |
| acrolein | NA | chemical toxicant | NA | -1.93e+00 | NA | 5.5e-01 | ADAM10,CCND1,PTGS2,XPA | NA |
| I-BOP | NA | chemical reagent | NA | -1.93e+00 | bias | 1.0e-02 | CCND1,ICAM1,PTGS2,SELE,VCAM1 | 1056 (13) |
| GSC | -1.05e+00 | transcription regulator | NA | -1.93e+00 | NA | 3.0e-02 | FOXC2,TGFB1,TWIST1,ZEB2 | NA |
| buthionine sulfoximine | NA | chemical drug | NA | -1.94e+00 | NA | 4.0e-02 | BCL2L1,CCR5,CD36,CXCR4,IL2RA,NFE2L2,NFKBIA,PTGS2,SERPINE1 | NA |
| NCOR-LXR-Oxysterol-RXR-9 cis RA | NA | complex | NA | -1.94e+00 | NA | 1.1e-01 | ABCA1,ABCG1,ABCG4,CD36,LPL,PLTP,SREBF1 | NA |
| ADP | NA | chemical - endogenous mammalian | NA | -1.94e+00 | NA | 3.1e-01 | CREM,F3,SELP,SERPINE1 | NA |
| FNDC5 | -1.17e+00 | other | NA | -1.94e+00 | NA | 1.0e-02 | BDNF,COL1A1,Cox8b,FNDC5,PRDM16,RUNX2,SPP1 | 626 (7) |
| Smad2/3/4 | NA | group | NA | -1.94e+00 | bias | 1.0e-02 | ACTA2,CDH2,NOX4,SERPINE1,SNAI1,SNAI2,TIMP1 | 1342 (15) |
| PADI4 | -3.10e-01 | enzyme | NA | -1.94e+00 | NA | 9.0e-02 | BCL2L1,CDKN1A,GADD45A,NLRP3,PYCARD | NA |
| 4-tert-octylphenol | NA | chemical toxicant | NA | -1.94e+00 | NA | 2.4e-01 | ADIPOQ,DLG3,EMP1,ITGAE,Ldha/RGD1562690,Marcks,S100A6,STAR | NA |
| H19 | NA | other | NA | -1.94e+00 | NA | 0.0e+00 | ACTA2,COL2A1,COL3A1,MMP14,RHOA,RPS6KB1,SNAI2,STAR,TGFB1 | NA |
| G6PD | -9.80e-01 | enzyme | NA | -1.95e+00 | NA | 0.0e+00 | ADIPOQ,CYBB,G6PD,MX1,NCF2,NOX1,PPARG,PTGS2,RETN,SREBF1 | 1463 (19) |
| MAFB | 8.00e-02 | transcription regulator | NA | -1.95e+00 | NA | 0.0e+00 | ADGRE1,ALCAM,ALDH1A3,AQP4,CCND2,CD28,CD53,CMKLR1,CXCL12,DLK1,EGR2,F13A1,F2RL3,FBLN5,FCGBP,FOXO1,GATM,HTR2B,IGF1,IL18BP,ITGA2B,ITGB7,LARS2,MAFA,MID1,MTSS1,NKX6-1,NUAK1,OLFML2B,OLFML3,PRDM1,PTGIR,RAB3IL1,RETN,SELENOP,SLC7A8,SLC9A9,TAGLN,TMEM119,ZNF189 | 585 (7) |
| TRH | -8.00e-02 | other | NA | -1.95e+00 | NA | 1.0e-01 | ANGPT2,CDK14,DUSP1,F2R,KCNA5,MITF,NR4A1,PRKCE,SFTPB,TPO | NA |
| E2F2 | -1.37e+00 | transcription regulator | NA | -1.95e+00 | NA | 1.0e+00 | CCNA2,CCND1,CDCA4,CDKN1A,CDKN2C,EZH2,MCM7,MYCN,POLA1,Raet1d/Raet1e,RBL1,SERPINE1 | NA |
| TEAD1 | -4.60e-01 | transcription regulator | NA | -1.95e+00 | NA | 0.0e+00 | ACADL,ACADS,ACSL1,ACTA1,ACTA2,AK5,ARID5B,CCND1,CDK6,CDKN1A,COL3A1,COL5A2,COX4I1,ECH1,EDN1,FIBIN,GSK3A,IGFBP5,KAZN,LIMCH1,LOXL1,MB,MSLN,MYH6,MYH7,NDUFA1,NDUFA7,NDUFAB1,NDUFB3,NDUFC1,NDUFC2,Ndufs5,NDUFS7,NDUFV2,NRXN2,NUAK1,PCDH18,PDGFRL,PPARD,PPARGC1B,PTGS2,PTPRO,RHOBTB1,SAMD5,SDC2,SH3D19,TAGLN,TGFA,THBS1,TLE1,TNNC1,TNNT2,TP63,UQCR11 | 1500 (22) |
| Usp17la (includes others) | NA | peptidase | NA | -1.95e+00 | bias | 2.0e-02 | Ccl2,CD44,CISH,KIT,KLF4,MMP2,PROM1,SNAI1 | NA |
| betaine | NA | chemical - endogenous mammalian | NA | -1.95e+00 | NA | 2.3e-01 | B2M,ESRRB,ESRRG,FGF2,SREBF1 | NA |
| lactic acid | NA | chemical - endogenous mammalian | NA | -1.95e+00 | NA | 1.0e-01 | AQP4,CXCL10,CXCL12,HIF1A,IGF1,IL17A,KDR,MRC1,SLC16A1,SLC16A3,SNAI1 | NA |
| PPIA | -1.98e+00 | enzyme | NA | -1.95e+00 | NA | 5.1e-01 | ACTA2,PPIA,SNAI1,TAGLN2 | NA |
| PLAAT4 | NA | enzyme | NA | -1.95e+00 | NA | 1.0e+00 | CXCL10,HRAS,IFIT1,ISG15 | NA |
| FXR ligand-FXR-Retinoic acid-RXRα | NA | complex | NA | -1.95e+00 | NA | 1.0e+00 | NR0B2,NR5A2,PLTP,SDC1 | NA |
| NCF1 | -1.90e+00 | enzyme | NA | -1.96e+00 | NA | 0.0e+00 | ACTA2,Ccl2,CD44,CDKN1A,EDN1,F3,FN1,HAS2,HYAL3,ICAM1,IFIH1,IGF1,IL17A,ISG15,SERPINE1,STAT1,TGFB1,THBD | 1020 (16) |
| NOTCH3 | -1.20e-01 | transcription regulator | NA | -1.96e+00 | NA | 0.0e+00 | ACTA2,APOD,CASP3,CDH1,CDH11,CDKN1A,COL14A1,COL18A1,COL3A1,COL5A1,COL8A1,DTX1,FN1,FOXP3,HEY2,ITGA1,ITGA11,ITGA3,ITGA9,ITGB3,KDR,MSI1,MSR1,NRARP,PRAG1,PRKCQ,PROM1,PTX3,SDC2,SNAI2,SPARC,TAGLN | 1010 (17) |
| SYK/ZAP | NA | group | NA | -1.96e+00 | NA | 1.0e-02 | CNOT6,E2F8,EPHB2,ETV5,FOXO1,IRF4,LMLN,PRDM1,PTGS2,TIMP1,UBE2F,VCAM1,VEGFC | 1281 (16) |
| ELMO1 | -8.70e-01 | other | NA | -1.96e+00 | bias | 1.0e-02 | DOCK2,EDN1,NOX4,TGFB1 | 1152 (7) |
| mannan | NA | chemical - endogenous mammalian | NA | -1.96e+00 | NA | 3.0e-02 | IRAK3,PTGS2,TLR2,TLR4 | NA |
| elastase | NA | group | NA | -1.96e+00 | NA | 1.7e-01 | Ccl2,ICAM1,MLKL,MMP2,TGFB1 | NA |
| NR1I2 | -3.00e-02 | ligand-dependent nuclear receptor | NA | -1.96e+00 | NA | 4.9e-01 | ABCA1,ABCB9,ABCC3,ADH1C,AHR,ALDH1A1,Ccl2,CCL24,CD36,CDKN1A,Ces1f,CYP27A1,CYP39A1,DHCR7,EGR1,FABP1,GLUL,Gsta4,IGF1,IL2RA,IL33,JAZF1,LTBP1,MGST1,NR0B2,PDIA4,PPARG,Slco1a4,SOCS1,SPHK1,SREBF1,TNFRSF11B,UGT1A4 | NA |
| GLS | 3.00e-02 | enzyme | NA | -1.96e+00 | bias | 0.0e+00 | ACTA2,COL1A1,FN1,HIF1A | 972 (7) |
| EDNRB | -8.00e-01 | G-protein coupled receptor | NA | -1.96e+00 | NA | 2.7e-01 | HIF1A,MITF,RHOA,VEGFC | NA |
| 4732491K20Rik | NA | other | NA | -1.96e+00 | bias | 2.0e-02 | Ccl2,ICAM1,PTGS2,SELE | NA |
| PTPRJ | -7.10e-01 | phosphatase | NA | -1.96e+00 | NA | 0.0e+00 | ACTA2,ARID5A,Ccl7,CCNA2,CEBPD,CITED2,EDN1,FCER1G,FGL2,HDC,INHBA,MET,OASL,PLA1A,PLAGL1,PLAT,PTGS2,RILPL1,SLA,TNFSF8,TPO,TSHR | 1372 (20) |
| NSD2 | -3.70e-01 | enzyme | NA | -1.96e+00 | NA | 0.0e+00 | BACE2,BTG2,CCND2,CCNE2,CXCR4,E2F2,ERCC1,GADD45A,HDAC4,IGF1,ITGB7,JAM2,RAB23,STAT1,TUBB4A,TWIST1 | 1342 (19) |
| BARX2 | -5.80e-01 | transcription regulator | NA | -1.96e+00 | NA | 0.0e+00 | ACTA2,DYNLL1,FLNA,L1CAM,MYH2,MYL3,MYOG,NCAM1,TIMP1 | 515 (7) |
| ATE1 | -2.40e-01 | enzyme | NA | -1.96e+00 | NA | 2.0e-02 | CCND1,CDH1,MYH7,REC8 | NA |
| U18666A | NA | chemical reagent | NA | -1.96e+00 | NA | 2.3e-01 | ABCA1,Akr1b7,CTSK,MMP14 | NA |
| hemoglobin | NA | complex | NA | -1.96e+00 | NA | 3.5e-01 | CDKN1A,EDN1,MGST1,PIR | NA |
| IGF2 | -2.80e-01 | growth factor | NA | -1.97e+00 | NA | 0.0e+00 | ARHGEF2,Ccl2,CCND1,CD36,CDKN1A,CKM,CORO2B,CXCR4,CYP1B1,DHCR7,DUSP1,EGR1,EGR2,FEM1A,FEN1,FN1,GADD45A,GCH1,HIF1A,IDH1,IER3,IGF1,IGFBP4,IGFBP5,IGFBP6,ITGA5,KLF9,MCM7,MYF5,MYOD1,MYOG,NFKBIA,OGN,PDGFB,PHLDA1,PIK3R1,PRDM16,PRKCQ,PTGS2,SELENOP,SERPINE1,SFTPB,SKAP2,SLC20A1,SLC38A2,SOCS3,SPP1,SREBF1,Srsf5,SURF6,TGFBI,THBS2,UHRF1 | 1511 (23) |
| FZD4 | -1.51e+00 | G-protein coupled receptor | NA | -1.97e+00 | NA | 0.0e+00 | ALDH1A1,CD34,CDH1,PLVAP,PROM1,SNAI1,TWIST1,VIM | 1397 (13) |
| 2,2’-dipyridyl | NA | chemical toxicant | NA | -1.97e+00 | NA | 1.0e-02 | LOX,LOXL2,NTRK2,RGS4 | NA |
| GABPA | -4.30e-01 | transcription regulator | NA | -1.97e+00 | NA | 2.0e-02 | CDK11A,CHRND,COX4I1,CYP7B1,GCLC,IL16,IL7,ITGB2,OXTR,PPARG,PRKDC,SKP2,Srsf5,TNC,TNFSF8,TSHR,UTRN | NA |
| GSN | -2.30e-01 | other | NA | -1.97e+00 | NA | 2.0e-02 | ACTA1,ACTA2,COL1A1,COL2A1,COL3A1,FN1,TGFB1 | NA |
| OXSR1 | 8.00e-02 | kinase | NA | -1.97e+00 | NA | 5.0e-02 | LHX8,SNAI1,SNAI2,TWIST1 | NA |
| NADPH oxidase | NA | complex | NA | -1.97e+00 | NA | 1.0e-02 | CYBB,EDN1,F3,NCF1,NOX1,PTGS2,SERPINE1,TGFA,VCAM1 | 1084 (15) |
| EPRS1 | 4.50e-01 | enzyme | NA | -1.97e+00 | bias | 2.0e-02 | ACTA2,COL1A1,FN1,LAMC2 | NA |
| CHRM1 | 1.60e-01 | G-protein coupled receptor | NA | -1.97e+00 | NA | 1.6e-01 | EGR1,EGR2,EGR3,NOS1 | NA |
| LMO4 | 3.30e-01 | transcription regulator | NA | -1.97e+00 | NA | 1.6e-01 | CCND1,NDN,PPARG,RETN | NA |
| CIB2 | 7.80e-01 | kinase | NA | -1.97e+00 | NA | 1.0e-02 | EIF4EBP1,LAMP2,MAP1LC3B,RPS6KB1 | NA |
| RPS6KA5 | NA | kinase | NA | -1.97e+00 | NA | 5.1e-01 | DUSP1,IL2RA,PTGS2,SNAI1 | NA |
| AHI1 | -1.00e-01 | other | NA | -1.98e+00 | NA | 0.0e+00 | BIN1,CMTM7,ELAVL1,GNAT1,GRHL1,HCK,IL1RN,IL4I1,LMCD1,NTRK2,OXCT1,RAB8A,SV2B | NA |
| USP48 | NA | peptidase | NA | -1.98e+00 | bias | 1.0e-02 | CCND2,GLI1,MYCN,SLC9A3 | 991 (5) |
| Hoxa11os | NA | other | NA | -1.98e+00 | bias | 5.0e-02 | CASP3,FSTL1,NLRP3,PYCARD | NA |
| maneb | NA | chemical toxicant | NA | -1.98e+00 | NA | 2.4e-01 | BCL2L1,CACNA1E,CCL21,CEBPD,CEP290,INHBA,KCNA2,LAMC2,MBOAT2,NFAT5,NR4A1,ROCK1,STRBP | NA |
| IRS2 | -1.00e+00 | enzyme | NA | -1.98e+00 | NA | 1.9e-01 | CCND1,DNASE1L3,EGR1,GSK3A,IRS1,LPL,MX1,PPARG,SLC2A1,SREBF1 | NA |
| lysophosphatidylcholine | NA | chemical - other | NA | -1.98e+00 | NA | 0.0e+00 | ABCA1,AXL,BDNF,Ccl2,CD36,CD74,CD86,CYBB,DHCR7,EBP,EGR1,F3,FADS2,ICAM1,IL2RA,IRF5,LPL,LSS,MSMO1,MVD,MVK,NLRP3,NOD2,OLR1,PLP1,PPARG,PTGS2,RGS2,SELE,SERPINE1,SREBF1,TGFB1,TLR4 | 1251 (19) |
| P2RX4 | -9.00e-02 | ion channel | NA | -1.98e+00 | NA | 0.0e+00 | BDNF,Ccl2,CDH1,COL1A1,COL3A1,ICAM1,TWIST1,VIM | 941 (15) |
| FZD2 | -7.50e-01 | G-protein coupled receptor | NA | -1.98e+00 | bias | 2.0e-02 | COL1A1,RUNX2,SPP1,WNT5A | NA |
| hypochlorous acid | NA | chemical drug | NA | -1.98e+00 | bias | 3.0e-02 | ACTA2,ITGA3,ITGB3,SNAI2 | NA |
| WAKMAR1 | NA | other | NA | -1.98e+00 | NA | 5.0e-02 | CAMK2D,CDK6,DOCK5,DYNLL1,EDN1,EIF2AK3,FGF2,KAT5,KIF11,ZFAND4 | NA |
| ganglioside | NA | chemical - endogenous mammalian | NA | -1.98e+00 | NA | 5.0e-02 | Ccl2,ICAM1,INPP5J,PTGS2 | NA |
| atipamezole | NA | chemical drug | NA | -1.98e+00 | NA | 5.0e-02 | AQP4,Ccl2,EGR1,ICAM1 | NA |
| NEU1 | 6.70e-01 | enzyme | NA | -1.98e+00 | NA | 1.0e-01 | Ccl2,CYBA,CYBB,NCF2 | NA |
| theophylline | NA | chemical drug | NA | -1.98e+00 | NA | 1.0e-01 | GFAP,LGALS12,THBD,THBS1 | NA |
| Cyclin E | NA | group | NA | -1.98e+00 | NA | 1.4e-01 | CD34,CDKN1A,EGLN1,HIF1A,RBL1 | NA |
| zearalenone | NA | chemical toxicant | NA | -1.98e+00 | NA | 3.1e-01 | BCL2L1,CCND1,KITLG,TLR4 | NA |
| S100B | -9.30e-01 | other | NA | -1.98e+00 | NA | 3.9e-01 | Ccl2,CDKN1A,GFAP,NEFL | NA |
| VIPR1 | 5.00e-01 | G-protein coupled receptor | NA | -1.98e+00 | NA | 2.7e-01 | Ccl2,CD86,CXCL10,IRF1 | NA |
| exenatide | NA | biologic drug | NA | -1.98e+00 | NA | 4.2e-01 | ABCA1,ARG1,ICAM1,IRS2,MRC1,PER1,PTGS2 | NA |
| BMP6 | 5.30e-01 | growth factor | NA | -1.98e+00 | NA | 0.0e+00 | ACTA2,ADAMTS1,ADAMTS5,ADD3,AKTIP,BMP4,Cald1,CD44,CDKN1A,CDKN2C,CYP1B1,CYP39A1,E2F2,E2F5,EPHX1,ERRFI1,ETV5,GNB4,ID2,INHA,INHBA,INHBB,ITGA5,KLF4,MATN2,MYCN,MYH10,PCOLCE2,PITX2,PMEPA1,PMP22,PRKD1,PTGS2,SAP30,SEMA3A,SERPINE1,SLC20A1,SLC39A10,SMAD7,SNAI1,SORD,STAR,TAGLN,TEF,TIMP1,WNT2 | 1312 (20) |
| GLUD1 | 4.90e-01 | enzyme | NA | -1.98e+00 | bias | 0.0e+00 | LPL,MAPK3,SLC2A1,SNAI1 | 858 (7) |
| sodium phosphate | NA | chemical drug | NA | -1.98e+00 | bias | 0.0e+00 | ACTA2,MMP2,MYH7,RUNX2,SPP1,TAGLN | 1259 (17) |
| MEOX1 | -9.40e-01 | transcription regulator | NA | -1.98e+00 | bias | 0.0e+00 | BMP4,GATA4,GLI1,GLI2,MEOX1,SIX2 | NA |
| 20alpha-hydroxycholesterol | NA | chemical - endogenous mammalian | NA | -1.98e+00 | bias | 2.0e-02 | ABCA1,ABCG1,GLI1,PTCH1 | NA |
| CD70 | NA | cytokine | NA | -1.98e+00 | NA | 2.0e-02 | BCL2A1,CCND2,CD1D,CD44,CXCL10,IL2RA,PRDM1 | NA |
| 4-nitroquinoline-1-oxide | NA | chemical toxicant | NA | -1.98e+00 | NA | 3.0e-02 | CCNA2,CDH1,CDK6,CDKN1A,DVL1,EGR1,KIT,MKI67,PTGS2 | NA |
| CD82 | -5.00e-01 | other | NA | -1.98e+00 | NA | 3.0e-02 | BCAR1,DCN,LYN,TIMP1 | NA |
| P1,P4-Di(adenosine-5’) tetraphosphate | NA | chemical - endogenous mammalian | NA | -1.98e+00 | bias | 3.0e-02 | KIT,NR0B2,THBS1,TPH1 | NA |
| TNFRSF11B | -1.77e+00 | transmembrane receptor | NA | -1.98e+00 | NA | 4.0e-02 | Ccl2,COL1A1,IGF1,RUNX2,SDC1,SPP1,TNFRSF11B,WNT10B | NA |
| ceefourin-1 | NA | chemical reagent | NA | -1.98e+00 | bias | 5.0e-02 | ADIPOQ,CD36,LPL,PPARG | NA |
| FBXO42 | -1.70e-01 | other | NA | -1.98e+00 | bias | 5.0e-02 | CSF1,ICAM1,STAT1,VCAM1 | NA |
| desmosterol | NA | chemical - endogenous mammalian | NA | -1.98e+00 | NA | 1.0e-01 | ABCA1,ABCG1,ARG1,Scd2 | NA |
| RAG1 | -3.80e-01 | enzyme | NA | -1.98e+00 | NA | 1.5e-01 | CD86,COL2A1,CXCL10,IL2RA,IRF3,ISG15,PTAFR,RUNX2,SDC2,STAT1,TLR7 | NA |
| L-lysine | NA | chemical - endogenous mammalian | NA | -1.98e+00 | NA | 1.9e-01 | CASP3,CASP8,DDIT4,IGF1 | NA |
| PIK3CB | -3.00e-01 | kinase | NA | -1.98e+00 | NA | 1.9e-01 | APLN,HK1,SLC2A1,TGFB1 | NA |
| TRIM2 | -9.00e-02 | enzyme | NA | -1.98e+00 | NA | 0.0e+00 | EGLN2,FTL,G6PD,GCLC,GPX3,GSR,ITGA5,ITGB4,ITGB7,MSRA,NFE2L2,PTPA | 427 (7) |
| RAS | NA | group | NA | -1.98e+00 | NA | 0.0e+00 | ANPEP,ARHGEF2,B4GALT1,BCL2L1,BCL2L11,CAV1,CCND1,CDKN1A,CSF3R,CXCL10,EDN1,EGR1,FN1,GBP2,Ifi47,IGF1,IRF1,LRAT,MAOB,MET,MITF,MMP2,NOX1,PDGFB,PLD1,PPARD,PRDM1,PRDX1,PTGES,PTGS2,SERPINE1,SNAI1,SNAI2,SREBF1,STAT1,TFPI2,VIM | 1068 (16) |
| polyphosphate | NA | chemical - endogenous mammalian | NA | -1.98e+00 | bias | 2.0e-02 | ICAM1,SELE,SPP1,VCAM1 | NA |
| PLA2G5 | -1.28e+00 | enzyme | NA | -1.99e+00 | bias | 3.0e-02 | COL3A1,PLA2G5,PTGS2,VEGFC | NA |
| MYLK2 | 8.80e-01 | kinase | NA | -1.99e+00 | bias | 0.0e+00 | MYF5,MYH3,MYOD1,MYOG | 285 (7) |
| TPH1 | -9.00e-01 | enzyme | NA | -1.99e+00 | bias | 1.0e-02 | AEN,ARL6IP1,ARRDC3,BCL2L12,CCR5,CD244,FCMR,GIMAP4,GIMAP7,GPR171,HSPA1A/HSPA1B,IFI16,IL17A,IRAK3,LUM,MAP4K1,MPP7,NCAPG,PLA2G7,PPIC,PRC1,RPS15A,SLAMF1 | 586 (7) |
| PPRC1 | 1.50e-01 | transcription regulator | NA | -1.99e+00 | bias | 1.0e-02 | CLDN1,DDIT4,DUSP5,ERRFI1,ESM1,GNG11,MYCT1,OLAH,PHLDA1,PTGS2,RND3,SMYD1,TM6SF1,ZFP36L1 | NA |
| triacetyl-3-hydroxyphenyladenosine | NA | chemical reagent | NA | -1.99e+00 | NA | 2.0e-02 | ABCA1,ABCG1,ARG1,LCAT | NA |
| MC2580 | NA | chemical reagent | NA | -1.99e+00 | NA | 5.0e-02 | ICAM1,IFI16,IRF8,LY86 | NA |
| CRHR1 | NA | G-protein coupled receptor | NA | -1.99e+00 | NA | 2.0e-01 | AQP4,EDN1,MC2R,NECTIN3,SLC2A1 | NA |
| BRAF | 4.70e-01 | kinase | NA | -1.99e+00 | NA | 0.0e+00 | ACVR1,ADAMTS9,B3GALT6,B3GNT2,B3GNT5,BCL2L11,BIRC3,BTRC,Ccl2,CCND1,CD86,CDH1,CDH2,CDKN1A,COL14A1,COL16A1,COL18A1,COL1A1,COL27A1,COL3A1,COL5A1,COL5A2,COL8A1,CSF1,CSF1R,DSE,EGR1,EIF2AK3,EMCN,ERBB3,F3,FAP,FGF2,FN1,GCNT2,GGT5,HGF,HIF1A,ICAM1,IGFBP6,IGFBP7,ITGA8,ITGB3,LAMA3,LAMC2,LOXL1,LOXL2,LOXL4,MCOLN1,MITF,MME,MMP14,MMP15,MMP2,MSLN,NOTCH2,NUP210,PTPRF,RND3,SDC1,SERPINE1,SLC7A1,SNAI1,SPRY4,ST3GAL1,SUSD5,THBS1,TIMP1,TMEM132A,TMEM259,TNFRSF10A,TNFRSF11B,TPO,TSHR,TSPAN1,UGT8,UNC5B,VIM | 1395 (16) |
| SRA1 | 8.40e-01 | transcription regulator | NA | -1.99e+00 | NA | 2.0e-02 | ADIPOQ,CAV1,MC2R,PPARG,PRDM16,STAR,THBS1,TMPRSS2 | NA |
| dihydrotestosterone | NA | chemical - endogenous mammalian | NA | -1.99e+00 | NA | 0.0e+00 | ABCA1,ABCC4,ABCG1,ACKR3,ACO2,ACSL3,ACTA1,ADAMTS1,ADH1C,ADIPOQ,Akr1b7,ALDH1A3,ALDOA,AMD1,AMHR2,ANO1,APOD,ARF1,ARFGAP3,ARG1,ASAP2,ATP2A1,ATP2A2,AXIN2,B2M,BCAR1,BCL2L1,BGN,BMP15,BTG2,BUB1B,C1orf21,CA3,CASP1,CASP3,CASP8,CCNA2,CCND1,CCND2,CCNI,CD36,CD74,CDH1,CDH2,CDK2,CDKN1A,CDO1,CHI3L1,CKM,CMKLR1,COBLL1,COL3A1,COL5A2,CX3CL1,CYBB,CYP4B1,DCN,DCTPP1,DEPDC1,Dgcr6,DPP4,DYNLL1,E2F8,EGF,EGLN1,EGR1,EIF4EBP1,ELAVL1,ELN,ELOVL7,EPB41L4B,ETV1,EZH2,F2R,FAM89B,FBXO32,FGF2,FGFR1,FKBP5,FN1,FOXO1,Foxp1,FOXP3,FRK,FTL,FZD6,G0S2,GAP43,GAPDH,GFAP,GJB2,GLUL,GOLGA4,GPD1,GPI,GPX3,GRWD1,HECTD2,HIF1A,HINT1,HLA-A,HMGN1,HNRNPU,HOMER2,HOXA5,HOXC5,HSP90AA1,HSPA1A/HSPA1B,ID2,IGF1,IGFBP4,IGFBP5,IGFBP7,IL1RL1,INHBB,IQGAP2,IRS1,IRS2,ITGA2,JAG1,KCNH2,KITLG,KLF15,KRT19,LEF1,LGALS1,LOX,LPL,LTBP1,MAF,MAFF,MARK1,MME,MMP2,MSTN,Mt1,MYOD1,MYOF,NCF1,NEDD4L,NFKBIA,NOS1,NR4A1,NUCB1,OXTR,PAM,PC,PEA15,PER1,PFN1,PHGDH,PHLDA1,PLAGL1,PMEPA1,PPARG,PROS1,PRUNE2,PTGS2,RAB27A,RAB2A,RARG,RASSF9,RETN,RGN,RPL28,RPL37A,RPS24,RUNX1,RUNX2,SEC13,SEC14L2,SELENBP1,SELENOP,SFRP4,SFTPB,SGK1,SLC16A7,SLC19A2,SLC1A3,SLC1A4,SLC1A5,SLC25A16,SLC2A1,SLC2A5,SLC2A9,SLC4A4,SLC7A6,SLC7A8,SLCO3A1,SMARCD3,SNAI1,SNAI2,SORT1,SPARC,SPP1,SREBF1,STAR,STARD8,STBD1,SYP,TACC2,TGM4,THBS1,TKT,TMPRSS2,TWIST1,UAP1,UCN,UGDH,VCAM1,VCAN,VIM,WEE1,WNT4,WNT5A,ZBTB16 | 1681 (18) |
| N-methyl-D-aspartate | NA | chemical drug | NA | -1.99e+00 | NA | 0.0e+00 | AMIGO2,ATP2B3,ATP2B4,BCL2L1,BCL2L11,BDNF,C3,CALB1,CCR5,CD47,EGR1,FGF2,GFAP,HOMER1,LYPLA1,MAP1B,NTRK2,PSIP1,PTGS2,SERPINF2,SLC1A3,SLC7A1 | 1470 (22) |
| poly(dG-dC) | NA | chemical reagent | NA | -1.99e+00 | bias | 2.0e-02 | CXCL10,ISG15,RSAD2,STAT1 | NA |
| DBH-AS1 | NA | other | NA | -1.99e+00 | NA | 7.0e-02 | CCND1,CDK6,CDKN1A,SLC2A1 | NA |
| RBP4 | -7.10e-01 | other | NA | -2.00e+00 | NA | 2.0e-02 | ARG1,CASP1,Ccl2,MYH7,NLRP3,PYCARD,RARA,TGFB1,TLR4 | NA |
| FGF12 | -3.10e-01 | other | NA | -2.00e+00 | NA | 1.0e-02 | ACTA2,LMOD1,MYOCD,TAGLN | NA |
| ANO1 | -8.30e-01 | ion channel | NA | -2.00e+00 | bias | 3.0e-02 | ACTA2,CYBA,MYOCD,TAGLN | NA |
| monophosphoryl lipid A | NA | chemical drug | NA | -2.00e+00 | NA | 2.3e-01 | Ccl2,CD86,CXCL10,IL1RN | NA |
| TERT | -5.60e-01 | enzyme | NA | -2.00e+00 | NA | 0.0e+00 | ALDH1A3,ASNS,ATF3,B2M,CALU,CAV1,CCL24,CCND1,CDH2,CDKN1A,COL5A2,COLQ,CSF1,CTSC,CX3CL1,CXCL10,CXCL13,DUSP6,EIF5A2,ELK3,ETS1,F2R,FAM167A,FGF2,GNA13,ICAM1,IFI16,IFI44,IFIH1,IFIT1,IFITM3,IGFBP4,IL17A,IQGAP2,ISG15,KHDRBS1,KLF4,KRT19,LGR5,LIPG,MMP14,MMP2,MX1,NFKBIA,NSFL1C,OASL,Oasl2,PDGFC,PLOD2,PLTP,PROM1,PTGS2,RBBP4,SERP1,SPON1,SPP1,TACC3,TBX3,TIMP1,TNFRSF1B,TNFSF8,TWIST1,UBASH3B,VIM | 804 (18) |
| Pam3-Cys | NA | chemical toxicant | NA | -2.00e+00 | NA | 4.0e-02 | CD83,CD86,CXCL10,IL1RL1,IL1RN,IL2RA,PLAT,SELE,SERPINE1,TGFA,TLR2,TLR4,TNC | NA |
| MRAS | -6.80e-01 | enzyme | Inhibited | -2.00e+00 | bias | 0.0e+00 | CCND1,CDH1,DUSP6,ETV1,IRS1,SPRED2,VIM | 1339 (21) |
| ARHGAP21 | -5.00e-02 | other | Inhibited | -2.00e+00 | bias | 0.0e+00 | ARID5A,BATF,CITED2,CXCL10,FGL2,HDC,IL15RA,IRF1,NMI,PLA1A,PLAT,PTGS2,RBL1,RILPL1,SLCO3A1,TNFSF8 | NA |
| ATP2B2 | -2.10e-01 | transporter | Inhibited | -2.00e+00 | NA | 0.0e+00 | A2M,ATN1,C15orf48,Casp12,CDKN1A,DDR2,EIF4EBP1,GADD45A,IGFBP5,KIT,LOXL1,MMP14,MMP2,Mxra7,RPL22,SLC1A5 | 968 (7) |
| RBCK1 | -3.30e-01 | transcription regulator | Inhibited | -2.00e+00 | bias | 0.0e+00 | ATP1A1,CCND1,CXCL10,CXCR4,FOXO1,GBP4,GBP5,ICAM1,IL33,IRF1,NFKBIA,RIPK2,VCAM1 | 1342 (12) |
| ZNF24 | 1.30e-01 | transcription regulator | Inhibited | -2.00e+00 | NA | 0.0e+00 | CCL24,CCND2,MMP2,MYRF,SOX10 | NA |
| Snhg20 | NA | other | Inhibited | -2.00e+00 | bias | 1.0e-02 | ACTA2,CASP3,COL1A1,FN1 | NA |
| CACNA1C | -9.00e-02 | ion channel | Inhibited | -2.00e+00 | bias | 1.0e-02 | ACTA2,ANXA2,CAV1,PTGS2,S100A10 | 1275 (18) |
| DDP-38003 | NA | chemical reagent | Inhibited | -2.00e+00 | NA | 2.0e-02 | ICAM1,IFI16,IRF8,LY86 | NA |
| VIPAS39 | -5.00e-01 | other | Inhibited | -2.00e+00 | bias | 2.0e-02 | SELP,SPARC,THBS1,VWF | NA |
| POLE2 | -6.90e-01 | enzyme | Inhibited | -2.00e+00 | bias | 2.0e-02 | CCND1,CDH2,SNAI1,VIM | NA |
| P2RY4 | 4.20e-01 | G-protein coupled receptor | Inhibited | -2.00e+00 | bias | 2.0e-02 | ICAM1,SELE,TIMP1,VCAM1 | NA |
| RAPGEF4 | -6.30e-01 | other | Inhibited | -2.00e+00 | NA | 2.0e-02 | CDKN1A,CTSK,SPP1,THBS1 | NA |
| AKR1B10 | NA | enzyme | Inhibited | -2.00e+00 | bias | 2.0e-02 | CCND1,CD44,CDK6,MMP2 | NA |
| TEAD | NA | group | Inhibited | -2.00e+00 | bias | 2.0e-02 | ANKRD1,CAV2,CCND1,CD44,FN1 | NA |
| ERCC4 | 5.10e-01 | enzyme | Inhibited | -2.00e+00 | bias | 3.0e-02 | DIO1,FN1,IGF1,SNCA | NA |
| ARAF | 3.00e-01 | kinase | Inhibited | -2.00e+00 | bias | 3.0e-02 | CCND1,EMCN,MYOG,TNNT1 | NA |
| mir-499 | NA | microRNA | Inhibited | -2.00e+00 | NA | 5.0e-02 | MYH6,MYH7,MYL2,PPP3CA | NA |
| Ccl6 | -1.72e+00 | cytokine | Inhibited | -2.00e+00 | NA | 5.0e-02 | Ccl2,CTSK,CTSS,MMP2 | NA |
| cystemustine | NA | chemical drug | Inhibited | -2.00e+00 | bias | 5.0e-02 | PSMA6,PSMB1,PSMB5,PSMC1 | NA |
| PIAS4 | 7.00e-02 | transcription regulator | Inhibited | -2.00e+00 | NA | 7.0e-02 | FABP1,IRF1,LEF1,PDK4,SERPINE1 | NA |
| COPS8 | 4.30e-01 | other | Inhibited | -2.00e+00 | NA | 7.0e-02 | CCND2,CDK2,CDK6,CDKN1A | NA |
| 8,9-epoxyeicosatrienoic acid | NA | chemical - endogenous mammalian | Inhibited | -2.00e+00 | NA | 1.0e-01 | ADIPOQ,CD44,PIK3CG,PLAT | NA |
| FURIN | 4.90e-01 | peptidase | Inhibited | -2.00e+00 | NA | 1.1e-01 | BDNF,EGLN1,PTGFR,PTGS2,TGFB1 | NA |
| 1-naphthylisothiocyanate | NA | chemical toxicant | Inhibited | -2.00e+00 | NA | 2.3e-01 | ABCC3,F3,NR0B2,SCTR | NA |
| C1QTNF1 | -4.60e-01 | other | Inhibited | -2.00e+00 | NA | 3.5e-01 | FN1,NOX4,SCNN1G,SLC9A3 | NA |
| VCP | 6.00e-01 | enzyme | Inhibited | -2.00e+00 | NA | 3.8e-01 | Ccl2,CDKN1A,DUSP1,HERPUD1,PPIB,VCAM1 | NA |
| MBP | NA | other | Inhibited | -2.00e+00 | NA | 5.5e-01 | FOXP3,LEPR,PTPRC,TGFB1 | NA |
| TRPC1 | NA | ion channel | Inhibited | -2.00e+00 | NA | 0.0e+00 | CCND1,CCND2,CDK6,CDKN1A,FOXO1,HIF1A,KDR,MAP1LC3A,MYF5,MYOD1,MYOG,SNCA,SPHK1 | 1445 (20) |
| DDIT4 | 3.80e+00 | other | Inhibited | -2.01e+00 | NA | 2.0e-02 | CASP1,Ccl2,CXCL10,ICAM1,IL17A,IL33,MAP1LC3B,NFKBIA,NLRP3,NOX1,SREBF1 | NA |
| nicotine | NA | chemical drug | Inhibited | -2.01e+00 | NA | 0.0e+00 | AHR,ALDOA,BDNF,CACNA1D,Calm1 (includes others),CASP3,Ccl2,CCND1,CCND2,CD44,CD86,CDKN1A,CHP1,CHRNA1,CHRNA4,COL1A1,COL3A1,CTSK,DNM1,EDN1,EGR1,FEZ1,FGF2,FGF9,FN1,GCH1,GNAL,GSR,HIF1A,HOMER1,ICAM1,IGF1,IKBKE,IL17A,KCNJ11,KDR,LITAF,MDH1,mir-133,MMP2,MRC1,MYCN,NAPA,NTRK2,OTUD3,PENK,PLAT,PNMT,PPARD,PTGS2,SELE,SERPINE1,SERPINF1,SLC1A1,SLC20A1,SPP1,SREBF1,STAT1,TFPI2,TRPC6,UBE3A,VEGFC,VIM,WNT5A,ZFP36 | 976 (14) |
| C5AR1 | -1.08e+00 | G-protein coupled receptor | Inhibited | -2.01e+00 | NA | 1.0e-02 | ATP2A2,C3,C5AR1,Ccl2,CD28,CD36,CD86,COL1A1,DCN,EIF2AK3,FCER1G,FCGR1A,FCGR2B,IGF1,IL17A,LTBP1,LTBP2,PPARG,SELP,SERPINE1 | 1605 (19) |
| ROR1 | -3.40e-01 | kinase | Inhibited | -2.01e+00 | NA | 0.0e+00 | ABRACL,AXL,BANF1,CDH1,CDKN2C,EMP2,ERAP1,ETV5,FSTL1,ITGB2,KRT19,MAP1B,MAP2,MDFIC,PTPN6,SERPINE1,SGK1,SNAI1,SNAI2,STMN1,THBS1,TNNT2,TOP2A,VIM | 1233 (19) |
| 3-methylcholanthrene | NA | chemical toxicant | Inhibited | -2.01e+00 | NA | 1.0e+00 | CCND1,CD36,CYP1B1,GSR,Mt1,NEDD9,NR4A1,PTGES,PTGS2 | NA |
| benzo(a)pyrene | NA | chemical toxicant | Inhibited | -2.01e+00 | NA | 0.0e+00 | AHR,ALG2,ANXA1,BCL2L11,BTG3,C1QTNF2,CAMLG,CASP3,CDC25B,CDK14,CDK5R1,CDKN1A,CELF2,COL8A1,CYP1B1,DHRS1,DOK5,ECT2,EPHX1,FGF9,FYN,FZD1,G6PD,GCLC,GNAI1,Gsta4,HAS2,HRAS,HS6ST2,HSPA1A/HSPA1B,IER3,IGF1,IGFBP6,INHBA,INHBB,LCP1,LDB2,MAF,MAFF,MAP2K4,METTL21A,NMI,NR4A1,NR5A1,NUDT16,NUMBL,PDLIM1,PLCB1,PPP1R3C,PRKCQ,PRKD1,PSENEN,PTGS2,RAP1GAP,SELENBP1,SELP,SEMA5A,SERPINE1,SFRP4,SLC1A4,SNAI2,TGFB1,THBS1,TKT,TM2D2,TNFAIP2,VEGFD,XPA | 1444 (21) |
| mir-208 | NA | microRNA | Inhibited | -2.01e+00 | NA | 0.0e+00 | ENG,IL18BP,MYH7,MYH7B,MYL1,MYL3,SOX6,TNNC1,TNNI2 | NA |
| Wnt | NA | group | Inhibited | -2.01e+00 | NA | 0.0e+00 | ADAM10,ADAMTS5,CD34,CD44,CDH1,CDH2,GATA4,GLI1,ID2,KDR,LEF1,MPZ,PAX3,PITX2,PPARG,RUNX2,SDC2,SIX1,SNAI1 | 1371 (22) |
| LIF | -7.00e-02 | cytokine | Inhibited | -2.02e+00 | NA | 0.0e+00 | A2M,ACTA2,ALDH1A1,BATF,BCL2L1,BCL3,Ccl2,CCNA2,CCND1,CD34,CD44,CD9,CDH1,CDKN1A,CEBPD,CISH,CRP,CSF1R,CXCL10,E2F2,EGR1,ERAP1,FN1,FOXP3,GATA4,GFAP,GLUL,GPCPD1,HGF,HIF1A,HPSE,ID2,IFI16,IGF1,IL17A,IL2RA,IL34,IL7,IRF1,JAM2,KDR,KLF10,LBP,LIMS1,LPL,MMP14,MYH7,MYOG,NMI,PAPPA2,PIM3,PLD1,PPARG,PTGS2,RET,RGS4,SFRP4,SOCS1,SOCS3,SPP1,STAR,TAL1,TFCP2L1,TIMP1,TMEM176A,TMEM176B,TNC,TNFRSF11B,VWF,WNT5A,ZFP57 | 1237 (18) |
| GDNF | -2.80e-01 | growth factor | Inhibited | -2.02e+00 | NA | 1.0e-02 | BDNF,CASP3,CCND1,DPYSL2,EGR1,EGR2,ETV5,FN1,GFAP,GFRA1,HTR2A,ITGA6,KIT,KLC1,LGALS1,LMNB2,Naip1 (includes others),PENK,SOX10,SPHK1,TUBB4A | 1455 (22) |
| VEGFC | -8.70e-01 | growth factor | Inhibited | -2.02e+00 | bias | 0.0e+00 | ARG1,Ccl2,CXCR4,ITGA4,KDR,PROX1,PTGS2,VEGFC | 986 (14) |
| PDGF BB | NA | complex | Inhibited | -2.03e+00 | NA | 0.0e+00 | ABCA1,ACKR3,ACTA2,ADD3,ADRB2,AHR,AKAP12,ASAH2,ATF3,ATP2A2,BCL3,BDKRB2,BHLHE40,BMP3,BMP4,BRAP,C3,CAV2,Ccl2,Ccl7,CCND1,CD44,CDK2,CDKN1A,CDO1,CEBPD,CNN1,COL12A1,COL18A1,COL1A1,COL3A1,COL5A1,CP,CREB1,CRYAB,CSF1,CSF1R,CSRP2,DAB2,DCN,DUSP1,DUSP5,DUSP6,EDN1,EDNRB,EGR1,EGR2,EGR3,ELAVL1,ETS1,F3,FBLN5,FGF2,FGFR1,FHL1,FHL2,FLNA,FN1,FOXC2,FRZB,FZD1,FZD2,GADD45A,GBP2,GDA,GFPT2,GJA5,GJC1,GLUL,GPR183,GREM1,HDAC4,HOMER2,HRAS,HSD3B7,IER3,IGF1,IGFBP4,IL1RL1,INHBA,ITGA5,KLF10,KLF6,KLHL21,LBP,MAP2,MAP2K4,MAT2A,MGST1,MGST2,MMP14,MMP2,Mt1,NFIL3,NOS1,NOX4,NPR3,NR4A1,NR4A2,NR4A3,OLR1,Omd,OSBPL2,PAWR,PCOLCE,PDGFRA,PDLIM1,PHLDA1,PLAT,PLCG2,PLK2,PPARD,PPARG,PRRX2,PRSS35,PTGS2,RFC5,RGS2,RND3,RXRG,S1PR2,Scd2,SERPINE1,SGK1,SKP2,SLC1A1,SLC7A1,SNAI1,SOCS3,SPHK1,SREBF1,SYK,TAGLN,TGFB1,THBD,THBS1,TIMP1,TNC,TNFRSF11B,TRIB1,UCK1,UGDH,UNC5B,VCAM1,VCAN,YWHAQ,ZFP36,ZFP36L1 | 1478 (19) |
| CpG ODN 1668 | NA | chemical reagent | Inhibited | -2.03e+00 | NA | 0.0e+00 | BCL2L1,Ccl2,CD200,CD300LD,CD86,CXCL10,ICAM1,IL17A,IRAK3,ISG15,PRDM1,PTGS2,SOCS1,SOCS3,STAT1,TLR4,TLR5,TLR7 | 751 (18) |
| GAST | 1.00e-01 | other | Inhibited | -2.03e+00 | NA | 1.0e-02 | BTK,CCND1,CREM,DNAJA1,EGR1,GLI2,HDC,HERPUD1,JAG1,NFKBIA,PGK1,PIK3R1,PLA2G7,PPARG,PTGS2,RHOA,S100A6,SCTR,SELP,SLC18A2,SLC9A3,TGFA,TNC,VCAM1 | 1453 (22) |
| ISL1 | -9.00e-02 | transcription regulator | Inhibited | -2.03e+00 | NA | 2.0e-02 | A2M,ABCC8,ACTC1,ADGRG2,BMP4,CLIC6,CNTN2,DAB1,ETV1,ETV5,EYA1,GNAS,HOXB5,Irx5,KCNJ11,LILRB3,MYL1,NOVA1,NTRK2,PAPPA2,PIEZO2,RET,RUNX1,SCN7A,TRPV1 | NA |
| streptozocin | NA | chemical drug | Inhibited | -2.04e+00 | NA | 0.0e+00 | ABCC8,ADIPOQ,ADORA2A,ANGPT2,APLN,AQP7,ATF3,ATP1A1,ATP1B1,ATP1B2,BCL2L1,CACNA1B,CALB1,Ccl2,CD36,CDKN1A,COL12A1,COL1A1,COL3A1,CREB1,CREM,CXCL12,DPP4,EGF,EIF2AK3,ENO3,FBN1,FBXO32,FN1,GABARAPL1,GATA4,GFAP,GNAS,GPX3,GREM1,HIF1A,ICAM1,IGF1,IGFALS,IRS1,IRS2,JAG1,KCNJ11,KIT,LPL,MAF,MAP1LC3B,MC2R,MMP2,MSR1,MYH6,MYH7,NCF1,NFE2L2,NOS1,NOX4,OGT,OSTN,Pcsk1,PDGFRA,PDK2,PDK4,Pmaip1,PPARD,PPARG,PTGS2,PYGL,RETN,RUNX2,S100B,SELE,SELP,SERPINE1,SLC1A1,SLC1A3,SLC2A1,SLC2A5,SLC7A8,SPP1,SREBF1,TGFB1,TRPC3,TRPV1,UBC,UCP3,VCAM1,VIM | 1643 (19) |
| AIP | 5.60e-01 | transcription regulator | Inhibited | -2.05e+00 | NA | 0.0e+00 | ACKR3,ADGRG6,AHR,AHRR,C3AR1,CASP3,CMKLR1,CX3CR1,CYP1B1,CYSLTR1,DUSP1,F2RL1,GNG11,NPR3,PDE8A,PLAGL1,PRKCD,RASGRP1,RET,RGS18,RGS2,RGS4,RGS7 | 578 (7) |
| JUND | -1.57e+00 | transcription regulator | Inhibited | -2.05e+00 | NA | 0.0e+00 | BCL3,BDNF,C3,C3AR1,C5AR1,Ccl7,CCND1,CDH1,CXCL10,CXCL16,CYBB,F3,HIF1A,IKZF2,ITGB4,JUND,NCF2,NOX4,NR4A1,NTS,PENK,RUNX2,SDC1,SERPINB9,SOCS1,SPP1,TIMP1,TWIST1 | 1449 (20) |
| ROCK2 | -3.00e-02 | kinase | Inhibited | -2.05e+00 | NA | 0.0e+00 | ACTA2,BATF,BCL6,Ccl2,CD44,CNN1,Cox8b,CXCR5,ICAM1,IRF4,MAF,MSN,MYF6,MYOD1,PPARG,PRDM1,SERPINE1,SPP1,TAGLN,VCAM1 | 996 (13) |
| GNRH | NA | group | Inhibited | -2.05e+00 | NA | 4.0e-02 | ADIPOQ,ATF3,DUSP1,EGR1,IGFBP5,INHA,MAPK3,PTGS2,SEMA3A,SEMA6B,SGK1 | NA |
| WWTR1 | 4.70e-01 | transcription regulator | Inhibited | -2.06e+00 | NA | 0.0e+00 | AK5,AUTS2,BMP4,CASP3,CCNA2,CCND1,CD44,CDKL2,CDKN1A,CKM,COL1A1,EMP1,EXOC3L2,FGF10,FMOD,FN1,ICAM1,ID2,IFIH1,INHBA,IQGAP2,ITGB2,KDR,LAMA3,MC2R,MX1,MYOG,NR5A1,PLIN4,RUNX2,SERPINE1,SMAD7,SPP1,STAR,STAT1,THY1,TNFRSF10A,TNFRSF8,TP63,TRAPPC5,TYMS,VCAM1 | 1649 (27) |
| CEBPA | -5.20e-01 | transcription regulator | Inhibited | -2.06e+00 | NA | 0.0e+00 | A2M,ACSL1,ADCY7,ADH1C,ADH7,ADIPOQ,AGPAT2,AKAP12,ANPEP,ANXA1,APCDD1,APLN,APLNR,ARG1,ARHGEF5,ASNS,BCL2A1,BIN1,BTG1,BTG2,C3,C3AR1,CCNA2,CCND1,CCND2,CCR1,CD7,CDH1,CDKN1A,CEBPD,CHI3L1,CIITA,CKAP4,COL1A1,COX4I1,CSF1,CSF1R,CSF2RA,CSF3R,CTSK,CXCR4,DHCR7,EBF1,EDF1,EEF1A2,EGR2,EMCN,EMX2,EPHX1,FCGR1A,FHL1,FOXO1,FOXO3,FZD1,G0S2,GADD45A,GAPDH,GCH1,GLI1,GLRX,HAS2,HDAC4,HGF,ICAM1,ID2,IER3,IGF1,IGFBP4,IL1RN,IRF6,IRS1,IRS2,ISG15,ITGAL,KDM3A,KLF4,KLF5,LEPR,LGALS1,LITAF,LPL,MMRN1,MSI2,MYCN,MYF5,MYF6,MYOD1,MYOG,NFIL3,NR4A2,NR5A2,NRP1,OLR1,OXTR,PLIN1,PLOD2,PLXND1,PPARD,PPARG,PPP1R3C,PRDM1,PTAFR,PTGFR,PTGS2,PTPN3,PTPRC,PTX3,RAB31,RBL1,RETN,RGL1,RGS2,RUNX2,SEMA3E,SERPINE1,SERPINF1,SFTPB,SOCS3,SPNS2,SPP1,SREBF1,STAR,TBXAS1,THBD,THBS1,TNFAIP6,TNFRSF10A,TNFRSF19,TRIB1,VCAN | 1463 (20) |
| WNT7A | NA | cytokine | Inhibited | -2.06e+00 | NA | 0.0e+00 | CDH1,CDH2,FGF1,LBH,MYOD1,RUNX2,SPRY4,TWIST1,VIM,WNT4,WNT5A | 1489 (25) |
| reactive oxygen species | NA | chemical toxicant | Inhibited | -2.06e+00 | NA | 0.0e+00 | ACTA2,ADAM10,ADAM17,ADIPOQ,BCL2L1,CASP1,CASP3,CD200,CDKN1A,CSF1R,CXCR4,EDN1,EIF4EBP1,ERBB3,ETS1,F3,FGF2,FOXO3,GADD45A,GLRX,GZMB,HIF1A,HPSE,ITGB3,KLF6,LPIN1,MAFA,NFE2L2,PRDX5,PTGS2,RRAD,SERPINE1,SUMO2,SYP,TGFB1,TLR2,TRPV1,VCAM1 | 1527 (19) |
| ozone | NA | chemical toxicant | Inhibited | -2.06e+00 | NA | 1.0e-02 | Ccl2,Ccl7,CCR3,CLDN1,CTNNAL1,CXCL10,F3,ICAM1,IL17A,ITGB4,NFE2L2,OCLN,SOCS3,SPP1 | 874 (14) |
| ionomycin | NA | chemical reagent | Inhibited | -2.07e+00 | NA | 0.0e+00 | ATP2A2,BCL2A1,BCL2L1,BDNF,BTK,CASP3,CCND2,CD276,CXCL10,DUSP1,DUSP5,EGR1,EIF4EBP1,ERFE,ETS1,FCGR1A,FOXP3,GBP4,GCH1,GZMB,HIF1A,HPSE,HTR2A,HTR7,ICAM1,IL17A,IL2RA,IL4I1,IRF4,ITGAL,ITGB2,ITM2A,MAF,MYL2,NDFIP2,NFAT5,NFIL3,NR4A1,NR4A2,NRP1,PKM,PPARG,PRKCZ,PTAFR,PTGS2,PTPRJ,RGS2,SGK1,SLAMF1,SLC18A2,SLC2A1,SPP1,STAT5B,TGFB1,TLR2,TRAF5,ZBTB16 | 1137 (14) |
| arotinoid acid | NA | chemical toxicant | Inhibited | -2.07e+00 | NA | 1.0e-02 | ABCA1,ALDH9A1,CDKN1A,CNR1,DUSP1,FOLR2,PLTP,RARA,RARG,RARRES1 | 1040 (18) |
| QKI | NA | other | Inhibited | -2.08e+00 | NA | 0.0e+00 | ACTA1,ACTN2,ANKRD1,C1R,CAV1,CD36,CDH1,CLEC4M,CNN1,CSF1R,CTSS,DACT1,DHCR7,FYN,GFAP,GPM6A,HLA-DQA1,LAMP2,LSS,MAP1B,MFAP5,MSMO1,MVD,MVK,MYH7,MYL2,NOS1,NSG2,PEA15,PTPRO,SNX3,TAGLN,THBS4,TNC,TNNT2,VCAM1,VIM | 945 (9) |
| KCNJ2 | 1.00e-02 | ion channel | Inhibited | -2.08e+00 | bias | 0.0e+00 | APBA1,ATRX,CEP290,CNTLN,COL11A1,COL12A1,COL2A1,CROCC,DLC1,GAS7,IQGAP2,KIF19,KIF1A,KIF21B,KIF5A,KIF5C,LIMCH1,MAP1A,MAP1B,MICAL2,MYH10,MYH14,MYO15A,MYO18A,MYO5A,MYO7A,MYOG,NAV1,OBSCN,PROX1,RASGRP1,ROCK1,SCN1A,SHROOM4,SIPA1L1,SPECC1,SPTB,SPTBN2,UTRN | NA |
| CREBBP | -1.00e-01 | transcription regulator | Inhibited | -2.09e+00 | NA | 0.0e+00 | ADORA2A,AKAP12,AMHR2,AMPD1,ARHGAP24,ARHGEF3,ARID5A,AXL,B2M,BANK1,BCL6,BDKRB2,CAMK2D,CARD6,CCND1,CCND2,CCR5,CD44,CD53,CDC42EP3,CDH1,CDKN1A,CKM,CNN3,COL2A1,CORO2B,CSF1,CST7,CXCL10,CXCL12,CXCR4,CYBB,DNAJB4,DTX1,DUSP1,EDARADD,EGR1,EGR2,EGR3,EPSTI1,ERCC1,EVI2A,EYA2,FGF2,FMNL2,FUT7,GFRA1,GIMAP4,GIMAP7,GLI1,GM2A,GNAS,GNG2,GRIA2,GRIN2D,HAS2,HLA-DRA,HVCN1,IL10RA,IL17A,IL17RE,IL18R1,IL2RA,IL2RB,INHA,IRF1,IRF6,ISG15,ITGA6,ITGA9,ITGB7,JUND,KCNIP3,KCTD1,KLHL4,LPL,MAF,MFHAS1,MIA,MPZ,MYH7,MYO1F,MYOD1,NABP1,NFE2L2,NFKBIA,NPAS2,NR4A1,NR4A2,NR4A3,NTN1,OAS3,PDE10A,PDE3B,PDLIM4,PLEKHF1,PRKCD,PTGS2,PTPRF,RAPGEF4,RCSD1,RETN,RGL1,RGS2,RHOA,RNF157,RSAD2,RTP4,RUNX2,SDC1,SDC4,SELE,SELP,SFTPB,SLAMF1,SLC18A2,SMOC1,SMPD3,SOCS3,SREBF1,ST6GAL1,STAR,TAGLN,TESC,TIPARP,TLE2,TLR2,TM2D2,TMEM38A,TMPRSS2,TNC,TNFAIP8L2,TRPM1,TUBA8,TULP4,TWIST1,USP18,UTRN,VCAM1,ZFP36L2 | 1313 (19) |
| PADI2 | 4.00e-01 | enzyme | Inhibited | -2.09e+00 | NA | 0.0e+00 | ACTA2,ADAMTS9,Ccl2,Ccl7,COL1A1,FN1,HMGN1,MKI67,PTGS2,SNAI1,SNAI2,TNFRSF1B,VIM | 1165 (14) |
| EHMT1 | 1.20e-01 | transcription regulator | Inhibited | -2.09e+00 | NA | 0.0e+00 | ACSL1,ANPEP,ATP1A1,BCR,BEST1,C3,CDH1,CDKN1A,CDKN2C,CEBPD,CILP,CP,EDN3,EYA4,HPD,ITGA3,MAN1C1,MEGF9,MGST1,MMP28,MSLN,MSRB1,PSD4,RAB11FIP3,RARRES1,RGCC,RRAD,RXRA,SELENBP1,SHMT1,SMPDL3B,ST3GAL1,STRA6,SYBU,TLE2 | NA |
| SMARCA2 | 3.80e-01 | transcription regulator | Inhibited | -2.09e+00 | NA | 0.0e+00 | ACTA1,CD36,CD44,CDH1,CDK2,CIITA,COL11A1,COL7A1,CP,CXCL13,DMP1,FKBP5,IGFBP5,KDR,LAMC2,MPZ,MYOG,PPARG,RAB27A,RBL1,TAGLN,TYMS | 1305 (21) |
| MITF | -6.70e-01 | transcription regulator | Inhibited | -2.09e+00 | NA | 0.0e+00 | ACO2,ACP5,ACSL1,ALCAM,AMDHD2,AP1B1,AP1S2,ATP1A1,ATRX,BEST1,C8orf44-SGK3/SGK3,CA14,CD44,CDC25B,CDK2,CDK5R1,CDKN1A,CENPF,CHKA,CLCN7,CMA1,COL1A1,COL2A1,COX4I1,CREM,CTSK,DAPK1,ECT2,EDNRB,ESPL1,FANCA,FBXO32,FGD4,FMOD,FN1,GLI1,GM2A,GPNMB,GZMB,HIF1A,HPS3,INPP4B,IRF4,ITGA3,ITGA4,ITPKB,KAZN,KIF4A,KIT,LYST,Mcpt4,MDH1,MET,MICAL1,MITF,MMP14,PIR,PLA1A,PLK1,PPM1H,RAB27A,RAB7A,RFC5,SDC1,SEMA3C,SERPINE1,SERPINF1,SHTN1,SLC19A2,SLC7A8,SNAI1,SORT1,SOX10,SOX6,SPC25,ST3GAL6,TACC3,TBC1D16,TDRD7,TMCC2,TPH1,TRPM1,VAT1,ZFYVE16 | 1519 (23) |
| Gsk3 | NA | group | Inhibited | -2.10e+00 | NA | 5.0e-02 | BCL2L11,CCND1,CDH1,COL2A1,FSCN1,HIF1A,ICAM1,IRS1,KDR,MYH6,NR4A1,NR4A2,PPARG,PTGS2,SNAI1,SPP1,SREBF1,STAT1,TNNC1,TWIST1 | NA |
| leukotriene D4 | NA | chemical - endogenous mammalian | Inhibited | -2.10e+00 | bias | 0.0e+00 | ADAMTS1,ARID5B,ATF3,CDH1,CREM,CYSLTR1,DUSP1,EGR1,EGR2,EGR3,F3,HLX,KLF4,NEDD9,NR4A1,NR4A2,NR4A3,PDK4,PTGS2,RGS2,SELE,ZFP36 | 1377 (22) |
| CDK5 | 2.90e-01 | kinase | Inhibited | -2.10e+00 | NA | 1.2e-01 | BDNF,CASP3,CDKN1A,LPL,LRG1,MAP2,NFAT5,PLP1,PSMB5 | NA |
| BAX | 2.80e-01 | transporter | Inhibited | -2.10e+00 | NA | 1.8e-01 | BCL2L11,CASP3,CDK2,CDKN1A,CTSH,CTSK,CTSS,CXCL10,EDEM1,ETV1,HLA-A,TIMP1 | NA |
| EPHB4 | -8.90e-01 | kinase | Inhibited | -2.11e+00 | NA | 0.0e+00 | BMP4,BMP5,CSF2RA,CXCR4,IGFBP4,KDR,KIT,KITLG,MYF6,MYL1,NCAM1,NEFL,PAX3,PDLIM7,PLP1,PPARGC1B,RUNX1,SMAD6,STAT5B,TAL1,TEK,TGFB1,WNT11,WNT5A | NA |
| PTGER2 | -3.80e-01 | G-protein coupled receptor | Inhibited | -2.11e+00 | NA | 0.0e+00 | ADGRE1,BUB1B,CCNA2,CDH1,CENPF,CSF1R,CXCL10,CXCR4,DEPDC1,ECM1,ECT2,EGR1,FOXP3,HDC,IL17A,ITGAL,KIF11,MKI67,PLK1,PRC1,PTGER3,PTGES,PTGS2,SERPINE1,SPP1,STAR,TBL3,THBS1,TIMP1,TNFAIP6 | 1191 (16) |
| Pdgf (complex) | NA | complex | Inhibited | -2.11e+00 | NA | 0.0e+00 | CAV1,Ccl2,CCND1,CCND2,CD44,CDK6,CDKN1A,CYBA,EDN1,EGR1,ERRFI1,F3,FGF2,FN1,FOXO1,FOXO3,HEY2,HIF1A,ICAM1,INHBA,IRS2,ITGA5,ITGB3,JAG1,MCM7,MEOX2,mir-143,MMP2,NCAM1,NOX1,NOX4,NR4A2,PIK3R3,PPARG,PTGS2,SERPINE1,SPARC,TGFB1,THBD,TIMP1,TWIST1,VCAM1 | 1163 (16) |
| CHD7 | 2.18e+00 | enzyme | Inhibited | -2.11e+00 | NA | 5.0e-02 | DHH,GATA4,GLI2,JAG1,MYCN,MYRF,NDN,NR5A1,Pmaip1,POLE4 | NA |
| SMAD1 | -5.00e-02 | transcription regulator | Inhibited | -2.12e+00 | NA | 0.0e+00 | ACTA2,BCL2L1,BTG2,CDKN1A,COL1A1,COL2A1,CSF1,GADD45B,GFAP,HHEX,ICAM1,ID4,IRF1,PDGFB,RUNX2,SELE,SMAD6,SMAD7,SPP1,VCAM1 | 1406 (21) |
| CTR9 | 4.30e-01 | other | Inhibited | -2.12e+00 | NA | 4.0e-02 | CXCL12,EGR3,IGFBP4,IL17A,PTGES,RAB31,RASGRP1,SDC1 | NA |
| Peg13 | NA | other | Inhibited | -2.12e+00 | NA | 8.0e-02 | DLK1,GAD1,GRIA2,HTR1B,HTR2A,RASGRF1,SNRPN,UBE3A | NA |
| CARD9 | -6.10e-01 | other | Inhibited | -2.12e+00 | NA | 1.7e-01 | C3,C5AR1,Ccl2,CCR1,CCR5,CXCL10,FCGR1A,TLR2 | NA |
| aldesleukin | NA | biologic drug | Inhibited | -2.12e+00 | NA | 2.7e-01 | B2M,CD86,FCGR2B,FCGR3A/FCGR3B,GLUL,HLA-DRA,IRF1,MX1,NUP62,STAT1 | NA |
| TFEB | 3.30e-01 | transcription regulator | Inhibited | -2.12e+00 | NA | 0.0e+00 | AHR,ALCAM,ALOX5,ARSB,ATP6V0B,ATP6V1A,BCL3,BCL6,BLOC1S1,BLOC1S3,BTG1,BUB1B,CALCRL,CCND1,CCNE2,CD48,CDH1,CEP290,CKAP4,CLCN7,COX6A2,CTSK,DKC1,E2F8,ECM1,EMP1,FAM111A,FOXP3,GATA4,GPR65,HIF1A,HOPX,HPS3,ICAM1,IL17A,IL33,JAG1,KIF23,MAP1LC3A,MCM7,MCM8,MCOLN1,MET,MITF,MSR1,MYH7,NCAPG,NCAPG2,NEU1,NUP210,NUP62,PDPN,PHLDA1,PLA2G7,PLK4,POLA2,PPARG,PTX3,RAB7A,SLC1A3,SLC36A1,SMC2,SOCS1,SPP1,SPRY4,ST8SIA4,TNFAIP6,TOP2A,TRPM1,VIM,XPO1 | 1034 (7) |
| JAK | NA | group | Inhibited | -2.12e+00 | NA | 0.0e+00 | BCL2L1,CD83,CDH2,CXCL10,FBXO32,HIF1A,IFIH1,IFIT1,IFITM3,IGF1,IL17A,IL33,ISG15,PTGS2,RSAD2,SOCS1,SOCS3,STAT1,TRIM63,VIM | 1011 (16) |
| E2F1 | -2.90e-01 | transcription regulator | Inhibited | -2.13e+00 | NA | 0.0e+00 | ACADL,ACSL5,ADIPOQ,ANGPT2,ARHGAP4,BCL2L1,BCL2L11,BMP4,Calm1 (includes others),CASP3,CASP8,CAV1,CCNA2,CCND1,CCND2,CCNE2,CD44,CD9,CDC25B,CDCA4,CDH1,CDH2,CDK2,CDK6,CDKN1A,CDKN2C,CITED2,CLIC1,COL2A1,COX4I1,CRYAB,CSDE1,CTNNBIP1,CWC27,DDAH2,DUSP1,DUSP10,E2F2,E2F8,ECT2,EGR1,EGR2,ENO2,Esrra,EYA2,EYA4,EZH2,FEN1,FGF2,FGFR1,FHL1,FOXO1,FOXO3,GM2A,GRAP,H2AC18/H2AC19,HLTF,HMGN1,Hmgn2 (includes others),HNRNPR,HSPE1,ICAM1,IDH3A,IGF1,IRS1,IRS2,KCNJ11,KDR,KIF23,KIT,LACTB,MAF,MAP3K14,MAPK14,MCM7,MDH1,mir-143,MYCN,MYH2,MYH7,Myh9,NDUFC1,NFKBIA,NFKBIB,NKX6-1,NMI,NR4A3,NRP1,NUDC,OAZ2,OGT,PAWR,PDK4,PIK3R1,PLK2,Pmaip1,POLA1,POLA2,PPARG,PPP1R13B,PPP1R3A,PRKAA2,PRKDC,PRPS2,PTPN4,Raet1d/Raet1e,RANBP1,RBBP4,RBL1,RFC2,RFC5,RND3,RPS16,SAFB,SELE,SERPINE1,SERPINF2,SLC16A1,SOX7,SRSF1,STMN1,TGFB1,THBS1,TOP2A,TP53BP2,TXNL1,TYMS,UGDH,UHRF1,UMPS,UQCR11,VCAM1,VCP,VIM,WEE1,ZFP36 | 1463 (19) |
| alendronic acid | NA | chemical drug | Inhibited | -2.13e+00 | NA | 2.3e-01 | C3,Ccl2,CCL24,CRP,FCGR3A/FCGR3B,FGF2,LBP,NCF2,OSMR,TNFRSF11B | NA |
| IL12A | -3.70e-01 | cytokine | Inhibited | -2.13e+00 | NA | 2.9e-01 | CD86,CXCL10,ICAM1,IL17A,SOCS1,SOCS3,STAT1,VCAM1 | NA |
| NFAT5 | -1.01e+00 | transcription regulator | Inhibited | -2.13e+00 | NA | 0.0e+00 | ACTN2,AQP4,ATP2A2,BCL2A1,C1QTNF6,C2,Ccl2,CCR1,CCR3,CD44,CD74,CFL1,CIITA,COL1A1,CXCL10,CXCL16,CYBB,DDIT4,EDN1,F3,GNA13,HECW2,HLA-DQA1,HSPA2,IFI16,IGFBP7,IL18R1,IL1RN,IRF1,ITGA1,ITGA4,ITGB3,JAM2,LAMA3,NFKBIA,NOX4,PLAT,POLA1,POLE4,PPARD,PRSS35,PTGES,PTGFRN,PTGIS,RFC2,RSAD2,S100A4,SCNN1G,SGK1,SLFN13,SPP1,STAT1,TLR2,TNC,TNFAIP2,TNFRSF11B,VCAM1,VWF | 1397 (21) |
| TRAF6 | -1.20e-01 | enzyme | Inhibited | -2.13e+00 | NA | 1.1e-01 | BIRC3,Ccl2,CRP,CXCL13,CXCL16,CYBB,GABARAPL1,HIF1A,ICAM1,IRF5,MAP1LC3B,MAT2A,NCF1,NCF2,NFE2L2,SELE,TGFB1 | NA |
| TYROBP | 1.10e-01 | transmembrane receptor | Inhibited | -2.14e+00 | NA | 0.0e+00 | ABCC4,CD83,CD84,CD86,FCGR2B,HLX,ICAM1,IL10RA,IRF8,ITGA5,ITGB4,LHFPL2,MAFA,NCF2,NCKAP1L,NOD2,NRROS,PLEK,SAMSN1,SLC1A5,SPP1,TGFB1,TNFRSF1B | 1186 (14) |
| Gli | NA | group | Inhibited | -2.14e+00 | NA | 0.0e+00 | ACTA2,CCND1,CCND2,COL1A1,FOXC2,GLI1,HIF1A,ITGB4,RUNX2,S100A4,SFRP1 | 923 (10) |
| CKAP2L | 9.00e-02 | other | Inhibited | -2.14e+00 | bias | 5.0e-02 | BUB1,CENPF,ESPL1,KIF23,KMT5A,NCAPG,PLK1,PLK4,SGO1,SGO2,SKA1,SPC25,TUBB4A,TUBB6 | NA |
| GNAQ | -3.20e-01 | enzyme | Inhibited | -2.14e+00 | NA | 0.0e+00 | ACTA1,ADAMTS1,AK4,ANKRD1,ARG1,ATF3,ATP2A2,BMP4,BTG2,C15orf48,Ccl2,Ccl7,CCND1,CD44,CITED2,Clec2d (includes others),CNN1,CREM,CSPG4,CX3CL1,CXCL12,DUSP5,EDN1,EGR1,EMP1,F2RL1,GADD45A,GBP2,Giot1/Zfp347,HAS2,IL1RN,KCNK2,KLF15,LMCD1,MAFF,MEOX2,MGST1,MYH7,NEU1,NFIL3,NPR3,NR4A1,NR4A2,NR4A3,OLR1,PDE10A,PHLDA1,PLAT,PLCB1,PRKCD,PRKCE,PRKG2,PTGS2,PTX3,PYGL,RELN,SELENBP1,SERPINE1,SGK1,SLCO4A1,SOCS3,SPHK1,STAR,STAT1,THBD,TNFAIP6,VCAM1,ZFP36L1 | 749 (13) |
| ZBTB17 | 3.10e-01 | transcription regulator | Inhibited | -2.15e+00 | NA | 0.0e+00 | BHLHE40,BTG3,BUB1B,CCNA2,CCND1,CDKN1A,CENPF,ECT2,EDA2R,EGR1,IER3,IQGAP3,KIF11,KIF4A,KIT,MKI67,OSMR,PLK1,PRC1,RHOA,SGO1,SGO2,SOCS1,TNFAIP2,TOP2A,ZFP36 | 1565 (20) |
| leupeptin | NA | chemical - protease inhibitor | Inhibited | -2.16e+00 | NA | 0.0e+00 | ABCA1,AXL,CAV1,CD9,FOXO1,HRAS,RGS4,SDC1 | NA |
| DLL1 | -1.80e+00 | enzyme | Inhibited | -2.16e+00 | NA | 3.0e-02 | CD86,CDH2,CDK2,CDKN1A,DLL1,EPHA4,HOXB5,IL17A,JAG1,SKP2,TAGLN | NA |
| 7-ketocholesterol | NA | chemical - endogenous mammalian | Inhibited | -2.16e+00 | NA | 4.0e-02 | CYBB,EGR1,ENG,GNAI1,ICAM1,ITGAL,KLF6,NOX4 | NA |
| ETV1 | -1.64e+00 | transcription regulator | Inhibited | -2.16e+00 | NA | 2.0e-02 | ACSL3,ADRB2,CXCR4,HPSE,IL7,ITGB3,MITF,TMPRSS2,TWIST1,VIM | NA |
| SNIP1 | 4.00e-02 | other | Inhibited | -2.16e+00 | NA | 4.0e-02 | CCND1,COL1A1,COL6A3,MMP2,SNAI1 | NA |
| MYO6 | -2.00e-02 | other | Inhibited | -2.16e+00 | NA | 0.0e+00 | ACTA2,ACTG1,ATF3,B2M,COL5A2,COL8A1,CSRP1,DNAJB4,DUSP1,DUSP5,DUSP6,ECM1,EGR3,ERRFI1,FAM53A,GCNT2,GLRX,HDAC4,HOMER1,IER3,IGFBP7,INHA,ITGB3,KLF9,LBH,LPIN1,MAST4,MID2,MXRA8,NR2F1,SDC4,SEMA3A,STX11,TAGLN,TNC,TNK2,TNNT1,TRPM4,TTLL3,USE1,VASH2,ZMAT1 | 1355 (12) |
| LTB4R2 | NA | G-protein coupled receptor | Inhibited | -2.16e+00 | bias | 2.0e-02 | EIF2AK3,IRF5,MMP2,NOX1,NOX4 | NA |
| ELK1 | 6.00e-02 | transcription regulator | Inhibited | -2.16e+00 | NA | 0.0e+00 | BCL2L1,CDKN1A,EGR1,EGR2,EGR3,IL7,JAM2,MTHFD2,NR4A1,PTGS2,RUNX2,SKP2,SLC2A1,SNAI1,SOCS3,SOX18,SPP1,TAGLN,THBS1,TIPARP,TPD52L1,TPO,ZFP36 | 1488 (23) |
| DCLK1 | NA | kinase | Inhibited | -2.16e+00 | NA | 2.0e-02 | SNAI1,SNAI2,SNCA,TWIST1,ZEB2 | NA |
| TNFSF14 | 4.00e-02 | cytokine | Inhibited | -2.16e+00 | NA | 0.0e+00 | ACTA2,BCL2L1,BIRC3,Ccl2,CD86,CDH1,CXCL10,CXCL12,F2RL1,HIF1A,ICAM1,INHBA,LOXL4,TGFB1,VCAM1 | 1238 (16) |
| epinephrine | NA | chemical - endogenous mammalian | Inhibited | -2.17e+00 | NA | 0.0e+00 | ADRA2A,ALOX15,AQP7,CCND1,CDK2,CDKN1A,CXCR4,DLK1,ERFE,GNAI3,HSP90AA1,IL33,LPL,MMP2,MYL2,OSTN,PENK,PER1,PLIN1,POLA1,POLA2,PTGS2,RETN,Slco1a4,TGFA,TLR5,TRIM63 | 1565 (22) |
| 24-hydroxycholesterol | NA | chemical - endogenous mammalian | Inhibited | -2.17e+00 | NA | 9.0e-02 | ABCA1,ABCG1,ABCG4,PTCH1,SREBF1 | NA |
| torin1 | NA | chemical reagent | Inhibited | -2.17e+00 | NA | 0.0e+00 | ADH1C,ALDH1A3,ALDH9A1,ALDOA,ATP6V0B,ATP6V1E1,ATP6V1F,BPGM,CCND1,CDH1,CDH2,COX4I1,COX6B1,EEF1A1,EEF1D,GAPDH,GPI,HK1,MITF,NDUFA1,NDUFA7,NDUFAB1,NDUFB3,NDUFC1,NDUFC2,NDUFS7,NTS,PGK1,PKM,PTGS2,RPL14,RPL17,RPL18,RPL22,RPL23,RPL28,RPL35,RPL36,RPL37A,RPL6,RPS11,RPS15,RPS15A,RPS16,RPS18,RPS2,RPS24,RPS3,RUNX2,TAGLN,UQCR10,VIM | 1503 (23) |
| platelet activating factor | NA | chemical - endogenous mammalian | Inhibited | -2.17e+00 | NA | 0.0e+00 | ANGPT2,CDH1,CDH2,CDKN1A,EGR1,EGR2,F3,FGF2,FN1,ICAM1,ITGB2,MMP14,MMP2,NFKBIA,NR4A1,PLA2G7,Ppp1r12a,PTAFR,PTGS2,SELP,SERPINE1,SOCS3,THBS1,TIMP1,VIM | 1070 (17) |
| EP300 | 3.00e-02 | transcription regulator | Inhibited | -2.17e+00 | NA | 0.0e+00 | ACADL,ACTA1,ACTA2,ADIPOQ,ADORA2A,AKAP12,ALDOA,AMHR2,AMPD1,ARHGAP24,ARHGEF3,ARID5A,AXIN2,AXL,B2M,BANK1,BCL2L1,BCL6,BDKRB2,BTK,CA12,CAMK2D,CARD6,CCND1,CD36,CD53,CDC42EP3,CDK2,CDKN1A,CHKA,CKM,CNN3,COL2A1,CORO2B,CST7,CTSE,CXCR4,DIO1,DNAJB4,DTX1,DUSP1,EDARADD,EDN1,EGR1,EGR2,ENO2,EPHB2,EPSTI1,Esrra,EVI2A,EYA2,FMNL2,FN1,FOXO1,GFRA1,GIMAP4,GIMAP7,GM2A,GNG2,H6PD,HVCN1,ID2,IGF1,IGFBP6,IL10RA,IL15RA,IL17A,IL17RA,IL17RE,IL18R1,IL1R1,IL2RA,IRF6,ITGA6,ITGA9,ITGB2,ITGB7,KCNIP3,KCTD1,KDM3A,KDR,KLHL4,LAMA3,LAMC2,MAF,MET,MFHAS1,MIA,MKI67,MME,MYO1F,MYOG,NABP1,NFKBIA,NPAS2,NPR1,NR4A1,NTN1,OAS3,OLR1,PDE10A,PDK4,PDLIM4,PFKFB3,PGK1,PKM,PLA2G4A,PLA2G7,PLEKHF1,POLE4,PRKCD,PTGS2,PTPRF,RAPGEF4,RCSD1,RETN,RGL1,RHOA,RNF157,RSAD2,RTP4,RUNX2,SDC1,SDC4,SELE,SKP2,SLAMF1,SLC16A3,SLC27A1,SLC2A1,SMAD6,SMAD7,SMOC1,SMPD3,SOCS3,SPHK1,ST6GAL1,TBXAS1,TESC,TIPARP,TLE2,TLR2,TM2D2,TMEM38A,TMPRSS2,TNC,TNFAIP8L2,TPO,TRPM1,TUBA8,TULP4,USP18,UTRN,ZFP36L2 | 1612 (20) |
| interferon beta-1a | NA | biologic drug | Inhibited | -2.17e+00 | NA | 0.0e+00 | ANAPC11,AOAH,CCR5,CORO1A,CSF1R,CST7,CXCR4,DNAJA1,DNAJB1,FCER1G,FCGR1A,FCGRT,GADD45B,GBP5,GNB4,GPR65,GZMB,IFIT1,IL16,IL1RN,IL2RB,IRF1,LGALS1,LILRB3,MAL,MRPS18B,MX1,NCF2,NDUFA1,NDUFB9,NFIL3,NFKBIA,NMI,PGK1,PPIA,RPL18,RPL22,SERPING1,SLC25A6,SNCA,STAT1,TBXAS1,TNFAIP6,TNFRSF1B,TRADD | 616 (10) |
| estradiol benzoate | NA | chemical drug | Inhibited | -2.17e+00 | NA | 7.0e-02 | AHR,BDNF,C3,Ccl2,CDH1,FOXO1,LEPR,NR5A1,OXTR,PAQR8,PENK,PLAT,PPARD,PTGS2,RARA,SYP,TGFB1,TGM4,UCP3 | NA |
| lactosylceramide | NA | chemical - endogenous mammalian | Inhibited | -2.18e+00 | bias | 1.0e-02 | Ccl2,Ccl7,CIITA,CXCL10,GFAP,HLA-DQA1,ICAM1,TLR2,VCAM1 | 1014 (14) |
| FASN | -4.80e-01 | enzyme | Inhibited | -2.18e+00 | NA | 0.0e+00 | ABCG1,ACTA2,ADIPOQ,ALOX5,CAV1,CD36,CDH1,CDH2,CREBZF,DDIT4,EDNRB,FGF1,FOXO1,GPAM,LPL,MET,MRAS,PNPLA2,PRKAR2B,PTGS2,RBP7,RETN,SFRP2,SIRT2,SKP2,VIM | 1499 (23) |
| PAX5-ELN | NA | fusion gene/product | Inhibited | -2.18e+00 | NA | 0.0e+00 | ASB10,CARD6,CD180,CYBB,EFNA5,HTR1B,IGSF10,IL2RA,IL2RB,IRS1,KDR,NKD2,PDE8A,PLK2,RGS18,SEMA6D,SH3BGRL2 | NA |
| PRMT7 | 5.60e-01 | enzyme | Inhibited | -2.19e+00 | NA | 0.0e+00 | BCL6,CDKN1A,GADD45B,IRF4,PRDM1 | 999 (17) |
| vinblastine | NA | chemical drug | Inhibited | -2.19e+00 | NA | 3.9e-01 | CD86,CDKN1A,DVL1,HIF1A,HLA-A,IGFBP4,PTGS2 | NA |
| SMAD4 | 2.30e-01 | transcription regulator | Inhibited | -2.19e+00 | NA | 0.0e+00 | ACVR1,ACVR1C,ANGPT2,ARHGEF2,BDNF,BGN,BMP4,BUB1,BUB1B,CBFB,Ccl2,CCL21,CCL24,CCND1,CCND2,CDC42EP3,CDH1,CDH2,CDH3,CDK17,CDK6,CDKN1A,CELF2,CITED2,CNMD,COL2A1,COL7A1,CSF1,DAPK1,EDN1,EIF4EBP1,ENG,FAP,FN1,FOXP3,FSCN1,FUT7,FZR1,GADD45A,GADD45B,GCNT1,GLI1,HAS2,HEBP1,HHEX,HMCN1,HRH2,ICAM1,ID2,IER3,IL17A,INHBA,INPP5D,IRAK3,ITGA6,ITGB7,JAG1,JAM2,KITLG,KLF15,LEF1,LPAR1,MET,mir-143,Msx3,MYCN,NFE2L2,NFKBIA,NPR2,PDGFB,PKM,PTGS2,PTPRC,PTX3,RGCC,RUNX1,RUNX2,SELE,SERPINE1,SFTPB,SGK1,SMAD6,SMAD7,SMO,SNAI1,SNAI2,SPHK1,STAR,TBX3,TGFB1,THBS1,TIMP1,TNC,TNFAIP6,TNFRSF10A,VIM,ZFP36 | 1519 (20) |
| arecoline | NA | chemical drug | Inhibited | -2.19e+00 | NA | 4.0e-02 | ACTA2,BCL2L1,F2R,MYOG,S100A4,SNAI1,TNFRSF1B,VCAM1 | NA |
| CD209 | NA | other | Inhibited | -2.19e+00 | NA | 9.0e-02 | CD86,JAM2,MMP2,OCLN,PTGS2 | NA |
| GHRH | NA | other | Inhibited | -2.19e+00 | NA | 2.3e-01 | CCND1,IGF1,KITLG,LEPR,MYOG,TRIM63 | NA |
| GRP | NA | growth factor | Inhibited | -2.19e+00 | NA | 5.4e-01 | CCND1,IL33,MYCN,PTGS2,TWIST1 | NA |
| WNT5B | -8.40e-01 | other | Inhibited | -2.19e+00 | NA | 0.0e+00 | ACTA2,CCND1,COL1A1,COL2A1,FN1,PROX1,VCAN | 603 (9) |
| TFE3 | 4.80e-01 | transcription regulator | Inhibited | -2.19e+00 | NA | 7.0e-02 | CDH1,Cox8b,CTSK,ESRRB,IRS1,IRS2,LOC100359583/Ptma,NDUFV2,PNPLA2,POLA2,PPARG,PPARGC1B,SERPINE1,SLC1A1,SMAD7 | NA |
| MAP2K2 | 7.30e-01 | kinase | Inhibited | -2.19e+00 | NA | 3.0e-02 | CDKN1A,ETV5,HIF1A,IRS1,ITGA2B,ITGB3,PDGFRA,PLD1,TNFRSF10A | NA |
| LTBR | 1.60e-01 | transmembrane receptor | Inhibited | -2.20e+00 | NA | 1.0e-02 | ACTA2,BIRC3,Ccl2,CCL21,CD74,CD86,CNN1,CXCL12,CXCL13,FAAH,GDA,ICAM1,NFKBIA,PCDH17,PDPN,PLXNB1,VCAM1 | NA |
| SMARCB1 | NA | transcription regulator | Inhibited | -2.20e+00 | NA | 0.0e+00 | A2M,ACSL1,ADD3,ARHGAP4,ATP1B1,BCL2L11,BMP4,BTG1,CCNA2,CCND1,CD44,CDH1,CDKN1A,CDKN2C,CEACAM1,COL14A1,COL18A1,COL1A1,COL5A2,CRP,CSF1,CXCR4,CYP39A1,DACH1,DAPK1,DOCK8,EMX2,FCGR1A,FOXP3,GJB2,GPC3,IFI16,IL15RA,KIF11,KIF23,KLHL4,KRT19,LBP,MX1,NUP210,OAS3,PC,PDGFB,PFKFB1,PLCL1,PLK4,POLA1,PPARG,PPP1R3C,PRKAB2,PTN,RFC5,RND3,SKP2,SLC37A4,SOX10,SPARC,TMOD1 | 1606 (20) |
| PIAS1 | 2.20e-01 | transcription regulator | Inhibited | -2.20e+00 | NA | 1.0e-02 | ACTA2,APBA2,BDNF,CACNB3,CCND1,CDKN1A,DNM1,EPHB2,GADD45A,GRIK4,KLF5,MYH6,MYOG,NR0B2,RRAD,SNCA,SREBF1,STAT1,SV2B,SYP,TAGLN,UNC13A | 1575 (21) |
| ADAM19 | -1.76e+00 | peptidase | Inhibited | -2.20e+00 | bias | 0.0e+00 | ACTA2,Ccl2,COL1A1,EGR2,FN1 | 1054 (10) |
| 12-hydroxyeicosatetraenoic acid | NA | chemical - endogenous mammalian | Inhibited | -2.20e+00 | bias | 0.0e+00 | ICAM1,NOX1,PTGS2,PTPRC,VCAM1 | 1359 (19) |
| TCF21 | -3.20e-01 | transcription regulator | Inhibited | -2.20e+00 | NA | 1.0e-02 | CDKN1A,CKM,MMP2,NR5A1,PITX2,TIMP1 | NA |
| ETS2 | 4.00e-02 | transcription regulator | Inhibited | -2.20e+00 | NA | 4.0e-02 | ANPEP,BCL2L1,BMP4,CD34,CDKN1A,CSF1R,CTSK,CYP27A1,DUSP6,ESRRB,FGF1,HPSE,ICAM1,IL2RA,ITGA2B,MSR1,SPP1,SYK,Tlr13 | NA |
| ZEB1 | 4.00e-02 | transcription regulator | Inhibited | -2.20e+00 | NA | 0.0e+00 | ALDH1A1,ANKRD1,AP1S2,CD74,CDH1,CDH2,COL1A1,COL3A1,CXADR,EDN1,ESRP2,FN1,ITGA1,ITGB4,KIT,KRT19,LAMC2,LOX,LOXL2,LPCAT1,MAL2,MAP1B,MMP2,MPZL2,MRC1,NRP1,NRP2,PKM,PTGS2,PTPRZ1,S100A10,SERPINE1,SFTPB,ST14,TGFBI,THBS1,TP63,VIM | 1355 (17) |
| CTSK | -1.00e+00 | peptidase | Inhibited | -2.20e+00 | NA | 0.0e+00 | Ccl2,CDKN1A,NLRP3,PPARG,PTGS2,TLR2,TLR4,TLR7 | 1259 (20) |
| 6-hydroxydopamine | NA | chemical toxicant | Inhibited | -2.21e+00 | NA | 0.0e+00 | BCL2L1,BDNF,C3,CASP1,CASP3,CEACAM1,CNR1,CXCL13,CYBB,DDIT4,GAD1,GADD45G,GAP43,GFAP,GNAL,HERPUD1,HSPA1A/HSPA1B,NCAM1,NLRP3,NOX1,NR4A2,PENK,PITX3,PPIB,PTGS2,PYCARD,S100B,SERP1,SNCA,UBC,UBE2D3,VCP | 1100 (16) |
| TREM1 | 1.00e-02 | transmembrane receptor | Inhibited | -2.21e+00 | NA | 0.0e+00 | ACKR3,ACSL3,ADRB2,ASNS,ATF3,ATP1B1,Ccl2,CCRL2,CD83,CD86,CFB,CSF1,CXCL10,CXCR4,E2F7,EDN1,EGR1,EGR2,EGR3,EIF2AK3,ELOVL7,F3,GADD45B,GREM1,HECW2,HOMER1,HS3ST3B1,HSD3B7,IL15RA,IL17A,IL1R1,IL1RL1,INHBA,IRF1,ISG15,LPL,LRFN4,MAD1L1,MAFF,MMP19,NEDD4L,NFKBIA,NFKBIB,NOD2,NR4A2,OASL,OAZ2,PHLDA1,PLD1,PLPP3,PPARG,PTGS2,RRAD,SIGIRR,SLC1A3,SLCO4A1,SPP1,TCEAL9,TFPI2,THBD,THBS1,TIFA,TLR2,TLR4,WNT5A | 1264 (16) |
| CpG ODN 2216 | NA | chemical reagent | Inhibited | -2.21e+00 | NA | 1.0e+00 | CD83,CD86,OAS3,STAT1,TNFSF18 | NA |
| C3 | -1.35e+00 | peptidase | Inhibited | -2.21e+00 | NA | 1.0e-02 | ACTA2,BCL2A1,C3,C3AR1,C5AR1,CASP3,Ccl2,CDH1,CRP,CSF1,CXCL10,CXCL16,FN1,IL17A,IRF3,PTPRC,SELP,SMAD7,TGFB1,THBD,TIMP1,UCP3,VCAM1 | NA |
| 16,16-dimethylprostaglandin E2 | NA | chemical - endogenous mammalian | Inhibited | -2.21e+00 | NA | 7.0e-02 | CD44,CXCR4,IL1RN,MMP2,NOX1 | NA |
| TIFA | -7.90e-01 | other | Inhibited | -2.21e+00 | NA | 9.0e-02 | BCL2L1,CASP1,CXCL10,ICAM1,NFKBIA | NA |
| cyclooxygenase | NA | group | Inhibited | -2.21e+00 | NA | 2.3e-01 | ARG1,IGF1,MRC1,PTGS2,RGS2 | NA |
| FGF9 | -1.13e+00 | growth factor | Inhibited | -2.21e+00 | bias | 3.0e-02 | BMP4,CCND1,FGF10,GCLC,PITX2,PTCH1,RUNX2,STAR,WNT4 | NA |
| xanthine | NA | chemical - endogenous mammalian | Inhibited | -2.22e+00 | NA | 0.0e+00 | CCR5,CXCR4,DUSP1,DUSP10,IL2RA,MMP14,MMP2,SLC2A1 | 1192 (18) |
| ARHGAP5 | -2.60e-01 | enzyme | Inhibited | -2.22e+00 | NA | 1.0e-02 | ACTA2,COL1A1,COL3A1,FN1,LOX | 1261 (13) |
| SNHG11 | NA | other | Inhibited | -2.22e+00 | NA | 7.0e-02 | AK4,CCND2,CDH2,TWIST1,VIM | NA |
| UBE3A | -6.00e-01 | enzyme | Inhibited | -2.22e+00 | NA | 1.1e-01 | CAMK2A,CDKN1A,NR4A2,SERPINE1,SNRPN,UBE3A,WNT4 | NA |
| diallyl disulfide | NA | chemical - endogenous non-mammalian | Inhibited | -2.22e+00 | NA | 4.8e-01 | ABCC3,ATF3,CASP3,GSR,NFE2L2,NOS1 | NA |
| SLC8A1 | 0.00e+00 | transporter | Inhibited | -2.22e+00 | NA | 0.0e+00 | EDN1,ICAM1,NFAT5,SELE,VCAM1 | 997 (9) |
| QRFP | NA | other | Inhibited | -2.22e+00 | bias | 0.0e+00 | ACSL1,CD36,LPL,PPARG,SLC27A1 | 538 (7) |
| ISGF3 | NA | complex | Inhibited | -2.22e+00 | bias | 1.0e-02 | HIF1A,IFIH1,IRF1,IRF5,ISG15,MX1,RSAD2 | NA |
| Pdgfr | NA | group | Inhibited | -2.22e+00 | NA | 5.0e-02 | ACTA2,EGR1,FN1,TNC,VIM | NA |
| ITGA5 | -1.14e+00 | transmembrane receptor | Inhibited | -2.22e+00 | NA | 1.0e-01 | CCND1,CD44,CDH2,CDK2,CDKN1A,COL2A1,MMP14,MMP2,PAX3,RAC2,SELP,WNT9A | NA |
| PTGIS | -1.48e+00 | enzyme | Inhibited | -2.22e+00 | NA | 2.0e-01 | ICAM1,NOS1,PTGES,PTGS2,YWHAQ | NA |
| IFITM1 | NA | transmembrane receptor | Inhibited | -2.22e+00 | NA | 2.0e-01 | DDAH2,EDIL3,GPM6A,LEPR,SELENOP | NA |
| CAST | 1.00e-02 | peptidase | Inhibited | -2.22e+00 | NA | 2.3e-01 | ACTA1,CDH2,IL17A,NCS1,RBL1 | NA |
| Z-LLL-CHO | NA | chemical - protease inhibitor | Inhibited | -2.22e+00 | NA | 0.0e+00 | AHR,ARHGDIB,ATF3,ATP1A1,BCAR1,BCL2A1,BCL2L1,BCL2L11,BIRC3,BUB1B,CAMK2A,Ccl2,CCND1,CCND2,CDH1,CDKN1A,CFB,CFL1,CISH,CLIC1,CRP,CRYAB,CXCL10,DCN,DDR2,DOCK2,DUSP1,EIF2AK3,EIF4EBP1,ELAVL1,ETS1,ETV5,EZH2,FADD,FGF2,FOXO1,G0S2,GCH1,GFAP,GLI1,GNAI1,HAS2,HIF1A,HNRNPL,HSF2,HSP90AA1,ICAM1,IER3,IKBKB,IRS1,IRS2,KCNH2,KLF5,LMOD1,MAD1L1,MAT2A,MET,MITF,MMP14,MMP2,MYCN,NCF1,NCF2,NFE2L2,NFKBIA,NOX4,OCLN,OPTN,PDGFRA,PEBP1,PEX5,PFKFB3,PFN1,PLK3,PPARG,PPIA,PPM1A,PRDM1,PRKAA2,PRKCZ,PSMC1,PSMD13,PTGFR,PTGS2,PTPN6,RANBP1,RARG,RGS4,RGS7,RPS6KB1,RUNX2,RXRA,SALL4,SFTPB,SGCA,SKP2,SLC1A1,SLC27A1,SNAI1,SOCS3,SORT1,STAT1,STMN1,THBS1,TIMP1,TNFRSF10A,TNK2,TP53BP2,TUBB4A,TWIST1,UBE3A,VCAM1,XPA | 1317 (14) |
| bucladesine | NA | chemical toxicant | Inhibited | -2.22e+00 | NA | 0.0e+00 | ABCA1,ACER2,ADAMTS1,AGL,ANXA1,AXIN2,BAMBI,BDKRB2,BDNF,C3AR1,C5AR1,CACNA1G,CALCR,CCND1,CCR5,CD44,CD86,CDH1,CDH2,CDK5R1,CDKN1A,CNP,COQ10B,CREB1,CREM,CRYAB,CXCL10,CXCR4,Dclk1,DCLK3,DIO1,DUSP1,DUSP6,EGR1,EGR2,ENO2,EPHA4,ERRFI1,ESM1,EZH2,F3,FAAH,FGFR1,FN1,FOXO1,GADD45B,GALNT16,GAP43,GCH1,GFAP,GLUL,HAS2,ICAM1,ID4,IGF1,IGFALS,IGFBP5,IGFBP6,IL17A,INHBB,IRAK2,IRF1,IRF8,IRS2,ITGA1,ITGA6,ITGB2,JAK3,KIT,KITLG,LGALS12,LPCAT1,LRRC73,MACROD1,MAN2A1,MAT2A,MME,MMP14,MMP2,Mt1,MYCN,MYOG,NCAM1,NKD1,NOX1,NR4A1,NR4A2,NR4A3,PDE10A,PDE4D,PDE5A,PDGFRA,PLAGL1,PLIN3,PLK2,PTCH1,PTGS2,RBL1,Rcan1,RET,RGN,RGS2,S100B,SEMA6D,SERPINE1,SFTPB,SLC2A1,SLC41A2,Slco1a4,SOCS3,SOX7,STAR,SYP,TC2N,TGFB1,THBD,TIMP1,TINAGL1,TPO,TSHR,TYRO3,UTRN,WHRN,WNT4,ZEB2 | 1456 (21) |
| desoxycorticosterone | NA | chemical - endogenous mammalian | Inhibited | -2.22e+00 | NA | 0.0e+00 | Ccl2,CCR5,COL1A1,CYBA,CYBB,NOX4,PTGS2,SERPINE1,SPP1,TGFB1 | 1410 (20) |
| MTM1 | -6.00e-02 | phosphatase | Inhibited | -2.22e+00 | NA | 2.0e-02 | EIF4EBP1,FBXO32,FOXO3,GABARAPL1,MAP1LC3A,MAP1LC3B,NEDD4L,TRIM63 | NA |
| CAMK4 | -5.20e-01 | kinase | Inhibited | -2.22e+00 | NA | 3.8e-01 | ABCA1,ACTA1,ATF3,BDNF,CDKN1A,CREM,CSRP1,F3,FOXP3 | NA |
| LY-3009120 | NA | chemical drug | Inhibited | -2.22e+00 | bias | 0.0e+00 | CCND1,DUSP6,ETV1,ETV5,SPRED2 | 1395 (15) |
| mocetinostat | NA | chemical drug | Inhibited | -2.23e+00 | NA | 0.0e+00 | BDNF,BEST1,CASP3,CDH2,CXCL10,ETS1,FN1,HDAC7,ITGA6,MITF,NOVA1,PDGFC,SERPINE1,UNC5C | 1076 (13) |
| BMP15 | -1.75e+00 | growth factor | Inhibited | -2.23e+00 | NA | 1.0e-02 | BMP15,HAS2,ID2,PTGS2,PTX3,SMAD6,SMAD7,STAR,TNFAIP6 | 1061 (21) |
| Msx3 | 8.90e-01 | transcription regulator | Inhibited | -2.24e+00 | NA | 0.0e+00 | IGF1,JAK3,MRC1,PPARG,STAT6 | NA |
| ETV2 | NA | transcription regulator | Inhibited | -2.24e+00 | bias | 0.0e+00 | EMCN,KDR,LMO2,SOX18,TEK | NA |
| TENM1 | NA | transmembrane receptor | Inhibited | -2.24e+00 | bias | 1.0e-02 | CHL1,EDNRB,ERBB3,GPNMB,SLC1A4 | NA |
| ANKRD17 | 6.00e-02 | other | Inhibited | -2.24e+00 | NA | 2.0e-02 | ARID5A,Ccl7,HDC,NMI,SOCS3 | NA |
| BMX | 3.80e-01 | kinase | Inhibited | -2.24e+00 | NA | 2.0e-02 | COL3A1,ENO2,HSPA1A/HSPA1B,MMP2,TIMP1,TNFRSF1B | NA |
| CAPN3 | 3.30e-01 | peptidase | Inhibited | -2.24e+00 | NA | 9.0e-02 | DUSP1,GPX3,NCF2,NOX4,PTGS2 | NA |
| EIF2A | -1.50e-01 | translation regulator | Inhibited | -2.24e+00 | NA | 9.0e-02 | ADIPOQ,CRP,EGR2,ICAM1,IGFBP6,PMP22,PTPRC | NA |
| peroxynitrite | NA | chemical toxicant | Inhibited | -2.24e+00 | NA | 2.0e-01 | ICAM1,LYN,MARCKSL1,PTGS2,RGS2 | NA |
| CA4 | -5.00e-01 | enzyme | Inhibited | -2.24e+00 | NA | 3.5e-01 | ACTA1,ANK1,EIF2AK3,ROS1,SLC10A6,SPTB | NA |
| sodium tungstate | NA | chemical drug | Inhibited | -2.24e+00 | NA | 4.8e-01 | ACO2,AK1,DPYSL2,ENO3,GFAP,TUBA1A | NA |
| IFNAR2 | -3.60e-01 | transmembrane receptor | Inhibited | -2.24e+00 | NA | 5.1e-01 | CXCL10,GBP4,IFI44,IFIH1,ISG15,UBA7,UBE2L6,USP18 | NA |
| MMP9 | -2.00e-02 | peptidase | Inhibited | -2.24e+00 | NA | 0.0e+00 | ACTA2,AXL,BCL2L1,CALCR,CARMIL1,Ccl2,CCND1,CD226,CD44,CDH1,CDKN1A,CLCN7,COL18A1,CTSK,CXCL12,CXCR4,DDAH1,DLC1,GADD45A,GAP43,HTR1B,ICAM1,JAG1,KIF1A,L1CAM,MATK,MDK,MMP14,MMP2,MSTN,NABP1,OCLN,PRKDC,SDC1,SDC4,TGFB1,THBS1,TIMP1,TRAF5,VIM | 1212 (19) |
| forskolin | NA | chemical toxicant | Inhibited | -2.24e+00 | NA | 0.0e+00 | ABCA1,ACER2,ACP5,ACTA1,ACTA2,ACTG2,ADAMTS1,ADGRA1,ADIPOQ,ADORA2A,AGL,AKAP12,AKIP1,Akr1b7,ALDOA,ARHGEF5,ATF3,ATP1B1,ATP6AP2,ATP6V0B,ATP6V1A,ATP9A,AVPI1,AXIN2,B4GALT1,BAMBI,BCL2L11,BCL3,BDNF,BHLHE40,BTG2,CACNA1I,CALCR,CCND1,CCND2,CD200,CD44,CD86,CD9,CDH2,CDK14,CDKN1A,CEBPD,CGREF1,CHRNA1,CMTM5,CNN1,CNP,COL18A1,COL1A1,CREB1,CREM,Crip2,CRYAB,CSF1,CXCL10,CXCL13,CXCR4,CYP1B1,DAB2,DAPK1,DDIT4,DHCR7,DMP1,DUOX2,DUSP1,DUSP6,ECM1,EDN1,EGR1,ELL2,EPHA4,ERFE,ERRFI1,ESM1,Esrra,EZH2,EZR,FBLN5,FKBP5,FN1,FOXO1,GADD45A,GADD45B,GADD45G,GAP43,GATA4,GCGR,GCH1,GFAP,GFRA1,GLI1,GNAL,GNAS,GPRC5C,GRK5,HAS2,HAS3,HIF1A,HLA-DQA1,HLA-DRA,HOMER1,HOXA5,HSPA1A/HSPA1B,HSPA2,ICAM1,ID2,IER3,IGF1,IGFBP5,IGFBP6,IL17A,IL2RA,INHA,INHBA,INHBB,IRS2,ITGA1,ITGA3,JAK3,JUND,KCNJ13,KITLG,KLF4,LAYN,LGALS12,LITAF,MACROD1,MAP1LC3B,MAPK3,MAT2A,MET,MGAT3,MITF,MMP19,MPZ,MSMO1,Mt1,MYCN,NFIL3,NFKBIA,NKD1,NR4A1,NR4A2,NR4A3,NR5A1,NTRK2,OSTN,OXTR,PAWR,PCDH11X,PDE4A,PDE4D,PDK4,PENK,PER1,PGK1,PGRMC1,PIM3,PLAGL1,PLAT,PLCL1,PLIN3,PLK2,POP5,PPP1R3C,PRDX1,PRKAR2B,PRKD1,PRKX,PROS1,PTGES,PTGS2,PTPRF,RAB27A,RAB31,RAB7A,RASGEF1B,RET,RGS18,RGS2,RGS4,RORB,RPL37A,RPS10,RPS11,RUNX1,RUNX2,S100A10,SEMA6D,SERPINE1,SFTPB,SGK1,SIK3,SLC18A2,SLC2A1,SLC2A5,SLC41A2,SLC7A8,Slco1a4,SMAD7,SPP1,SSBP1,ST8SIA2,STAR,STARD7,STAT1,TAGLN2,TFPI2,THBS1,TIMP1,TM4SF1,TMBIM1,TNFAIP6,TNFRSF11B,TPO,TRIB1,TSHR,TTF2,TUBA1A,UCN2,USP18,VCAN,VIM,WNT4 | 1320 (20) |
| FSTL1 | -1.20e+00 | other | Inhibited | -2.24e+00 | bias | 4.0e-02 | ACTA2,CASP1,Ccl2,COL1A1,EIF4EBP1,FN1,FSTL1,NLRP3 | NA |
| GLI2 | -5.90e-01 | transcription regulator | Inhibited | -2.25e+00 | NA | 0.0e+00 | ACTA2,ANO1,ATP2A1,BCL2L1,BMP4,CBFA2T3,CCL24,CCND1,CCND2,CCR1,CCR5,CDH1,CDKN1A,COL1A1,CXCL10,FOXC2,GATA4,GLI1,GLI2,IL1RL1,IRF6,JAG1,MEOX1,MITF,MYCN,MYOD1,NTN1,PAX3,PFKFB3,PTCH1,RUNX2,SFRP1,SMO,SNAI1,SPP1,TAF1C,TGFA,UGCG,VIM,WNT5A | 1572 (23) |
| GAS6 | 3.00e-01 | growth factor | Inhibited | -2.25e+00 | NA | 0.0e+00 | AXL,BCL2L1,IL17A,MSR1,PDGFRA,PROS1,PTGES,SNAI2,SOCS1,SOCS3,SOX10,TWIST1 | 852 (14) |
| clodronic acid | NA | chemical drug | Inhibited | -2.25e+00 | NA | 0.0e+00 | ADGRE1,ARG1,Ccl2,CD36,CD86,CXCL10,ICAM1,IL17A,MRC1,MSR1,SELE,SELP,TGFB1,VCAM1,WNT10B | 1520 (17) |
| IRF2 | -4.00e-02 | transcription regulator | Inhibited | -2.25e+00 | NA | 0.0e+00 | ARG1,B2M,CA12,CASP1,CCND1,CDK2,CDKN1A,CEACAM1,CFB,CIITA,CLIC1,CTSS,CXCL10,DPY19L1,DUSP5,ERAP1,FAM111A,FCGBP,IDH1,Ifi47,IL7,IRF1,IRF8,ISG15,KLF4,LBP,PFKFB3,PTGS2,RARRES1,SDC1,SLC7A1,SLCO2B1,SOCS1,TLR4,TLR5,UBE2L6,USP18,VCAM1 | 738 (17) |
| MYOCD | -1.09e+00 | transcription regulator | Inhibited | -2.25e+00 | NA | 0.0e+00 | ACTA1,ACTA2,ACTC1,ACTN2,ANO1,ATP2A2,BCL2L1,CACNA1D,Cald1,CASP3,CASQ2,CCBE1,CDKN1A,CNN1,COL1A1,COL2A1,COL3A1,ECM2,EIF2AK3,FAP,FBXO32,FN1,GATA4,GJA5,GJC1,HCN4,HEY2,HSPB7,LMOD1,mir-133,mir-143,MYH6,MYH7,MYL2,PHKA1,PLA2G2A,PTPRB,S100A4,SCN5A,SNAI1,TAGLN,TNNC1,TNNI1,TNNT2,VCAN | 726 (12) |
| entolimod | NA | biologic drug | Inhibited | -2.25e+00 | NA | 3.0e-02 | ADRB2,ATF3,BCL2A1,CXCL10,DUSP1,IER3,IRF1,NFKBIA,TNFAIP2 | NA |
| ATF4 | 3.40e-01 | transcription regulator | Inhibited | -2.26e+00 | NA | 0.0e+00 | ABCA1,ADAM10,AMPD1,ANKRD1,APBA3,ARHGAP24,ASNS,ATF3,BCAT1,BCL11A,BTG1,CA9,CDKN1A,CHAC1,CSRP3,CXCR5,CYP27A1,DDIT4,DDR2,DENND1B,EIF4EBP1,FAM102A,FN1,FUT7,FYN,GADD45A,GCH1,GHITM,HERPUD1,IGFBP5,IGFBP7,JAG1,KLF4,KLF9,MAP1LC3B,MGST1,MITF,MTHFD2,NAPA,NOX4,OSMR,PENK,PHGDH,Pmaip1,PMP22,PPARG,PRKDC,PRRX2,PTGS2,Ptprv,PTX3,SERPINF1,SFXN5,SLC1A4,SLC1A5,SLC38A1,SLC38A2,SLC38A3,SLC6A9,SLC7A1,SNAI2,SNTB1,SREBF1,TBC1D16,TCEAL5,TKT,TNFRSF11B,WNT11 | 1388 (21) |
| PPP3CB | 8.00e-02 | phosphatase | Inhibited | -2.26e+00 | NA | 0.0e+00 | CDKN1A,CYBB,FBXO32,FOXO3,GADD45A,IRS1,NOX4,RUNX1,TRIM63 | 1521 (26) |
| SAA1 | NA | transporter | Inhibited | -2.26e+00 | NA | 4.0e-02 | ARG1,BGN,Ccl2,CCND1,CTSK,CXCL10,IL17A,IL1RN,MMP2,MRC1,PPARG,SREBF1 | NA |
| GNA12 | 7.00e-02 | enzyme | Inhibited | -2.26e+00 | NA | 0.0e+00 | ACTA2,ALOX12,BAIAP2,CCNA2,CFL2,CNN1,DDR2,EZR,F2R,G6PD,GCLC,GNA13,GSR,Gsta4,IQGAP1,IRS1,ITGA6,ITGAE,mir-143,MMP2,PDGFRA,PIK3R1,PSMB5,PTGS2,RDX,RHOA,TAGLN,TRPC6,VAV2,VAV3,VIM | 1444 (20) |
| CXCL8 | NA | cytokine | Inhibited | -2.27e+00 | NA | 0.0e+00 | ACKR3,ACTA2,ANXA1,ARG1,BCL2L1,CD44,CD74,COL12A1,COL18A1,COL1A1,COL3A1,F3,ICAM1,IL2RA,ITGA1,ITGA5,ITGAL,ITGB2,KLF4,MMP2,NFKBIA,NOX1,OCLN,PLD2,PTGS2,SNAI2,SOCS1,SREBF1,STAR,TNFRSF10A,TP63,VCAM1,ZFP36 | 1623 (18) |
| Fcer1 | NA | complex | Inhibited | -2.27e+00 | NA | 3.0e-02 | ATP2A2,BCL2A1,Ccl2,Ccl7,CD83,CSF1,DUSP6,EIF6,FCGR2B,FYN,IL16,IL1RN,IL33,INHBA,MRC1,S1PR2,SPHK1 | NA |
| AKT1 | 5.10e-01 | kinase | Inhibited | -2.28e+00 | NA | 0.0e+00 | ACTA2,ACTC1,ANKRD1,ARL6IP1,ATP6V1E1,BCL2A1,BCL2L1,BCL2L11,BIRC3,CASP3,Ccl6,CCND1,CCND2,CD44,CD74,CD86,CDH1,CDK2,CDKN1A,CEBPD,CISH,COL8A1,CXCL10,CXCR4,DHCR7,DIAPH3,EBP,EGR1,EZR,FBXO32,FGF2,FN1,FOXO1,FOXP3,FSTL1,GATM,GCLC,GSR,HIF1A,HNRNPL,IGFBP5,IL2RA,IRS1,IRS2,JUND,KDR,KLF15,LDHB,LSS,MDH1,MMP14,MMP2,MSMO1,MSR1,MSTN,MYH10,MYH6,MYH7,MYL1,MYOCD,MYOG,NFATC3,NFE2L2,NOX4,PCOLCE,PDGFRA,PHLDA1,PIK3R1,PKM,PLA2G4A,PLP1,PPARG,PROM1,PTGS2,SEMA6D,SERPINE1,SERPINF1,SHOX2,SLC2A1,SNAI1,SNAI2,SORT1,SOX10,SPP1,SREBF1,SRP14,STAT6,THBS1,THBS2,TIMP1,TP63,TPD52L1,TRIM63,TYMS,UNC5B,VCAN,VCP,VIM | 1540 (17) |
| IFNA1/IFNA13 | NA | cytokine | Inhibited | -2.28e+00 | NA | 3.0e-02 | BCL6,CD83,CD86,CXCL10,DHX58,IFIH1,IFIT1,IRF1,ISG15,MX1,PTGS2,RSAD2,SOCS1,STAT1,UBE2E1,UBE2L6 | NA |
| NORAD | NA | other | Inhibited | -2.28e+00 | NA | 0.0e+00 | BHLHE40,CHST11,COL5A1,EGLN2,GADD45B,IGFBP4,LMCD1,NCOR2,PHLDB1,RHOA,SDC1,SEC14L2,SGK1,SLIT3,SMAD6,SSBP3,TAGLN,THBS1 | NA |
| cyclophosphamide | NA | chemical drug | Inhibited | -2.28e+00 | NA | 0.0e+00 | ATF3,B2M,CASP8,CD44,CD74,CP,DTX1,FADD,FOXP3,GAP43,GCGR,ICAM1,IER3,IL18R1,KAT5,KITLG,LAMC2,LGALS1,PLA1A,PTGES,PTGS2,RAC2,S100A11,SPP1,THBS1,TIMP1,TSPAN8,UGCG,ZFP36L2 | 1479 (17) |
| NOS2 | NA | enzyme | Inhibited | -2.29e+00 | NA | 0.0e+00 | ACTA1,ACTC1,ADIPOQ,ATP2A2,BCL2A1,CASP3,Ccl2,Ccl7,CD44,CD53,CD86,CDKN1A,CHI3L1,COX4I1,COX6A2,CP,CSF3R,CTSC,EDN1,FOXO1,FOXP3,G6PD,GPD1,HIF1A,IL17A,IL1RN,IRS1,IRS2,ISG15,KDR,KLF6,LPAR1,MB,MYH6,MYH7,MYL2,MYL3,NFKBIA,PC,PTGS2,SERPINH1,SFXN1,SLC1A5,Slfn2,SYP,Tcf7,TGFB1,THY1,TIMP1,TKT,TLR4,TNK2,TNNC1,TNNT2,TOR3A | 1518 (17) |
| UTP | NA | chemical - endogenous mammalian | Inhibited | -2.29e+00 | NA | 0.0e+00 | Ccl2,CDH2,F3,FLNA,HAS2,ICAM1,KCNC4,MB,SERPINE1,SPP1,THBS1,TLR4,VCAM1 | 1085 (18) |
| STK40 | -1.00e-01 | kinase | Inhibited | -2.30e+00 | NA | 0.0e+00 | ACTA1,ACTA2,C6,Ccl2,CCR5,CKM,DLK1,DUSP6,FGF1,FN1,HLA-DQA1,LEF1,MEOX1,MR1,MYH8,OSR1,PDGFRA,PDPN,PPARG,PTGS2,RSPO3,SFTPB,SPRY4,ST3GAL1,TLR4,TLR5,TXNRD3,WNT11,WNT2,WNT2B,WNT5A,WNT6 | 1065 (16) |
| FOXC2 | -2.60e+00 | transcription regulator | Inhibited | -2.30e+00 | NA | 0.0e+00 | ACTA2,ADIPOQ,ADRB2,ANGPT2,CASP3,CDH1,CDH2,COL1A1,COL2A1,CXCR4,DLL1,DMP1,FN1,GPNMB,IRS1,IRS2,ITGB3,ITGBL1,KDR,LEF1,LPL,MET,MMP2,OSTN,PLIN1,PPARG,PRDM16,PTGS2,RUNX2,SNAI1,SOX6,SPP1,TCF15,VIM,WNT5A | 1426 (22) |
| Bvht | NA | other | Inhibited | -2.31e+00 | bias | 0.0e+00 | ACTA2,ACTC1,ACVRL1,ALDH1A3,CSRP3,CYGB,EBF1,ETS1,FOXC2,GATA4,HBA1/HBA2,ITGA4,KDR,LIMCH1,MMP19,MYBPC3,MYH6,MYH7,MYL2,MYL3,SERPINF1,SMARCD3,SMYD1,SNAI1,SNAI2,TMOD1,TNNI1,TNNT2,TWIST1,UNC45B,VIM | 107 (4) |
| Klrk1 | -6.70e-01 | transmembrane receptor | Inhibited | -2.31e+00 | NA | 1.0e-02 | CCR5,CSF1,HLX,HOPX,IL18R1,IL1RL1,IRF8,Klrc2/Klrc3,PRDM1,SEMA4A,SPP1,STAT1 | NA |
| CCAR2 | 1.30e-01 | peptidase | Inhibited | -2.31e+00 | NA | 2.0e-02 | CAMK2A,CAMK2D,CCND1,CCNE2,CDK6,CNN3,CREB1,CREB5,KIF1A,PRKCB,SLC2A1,WEE1 | NA |
| SELPLG | -4.90e-01 | other | Inhibited | -2.31e+00 | NA | 4.0e-02 | BCL2A1,CDKN1A,CLK1,CXCR4,CYP1B1,GNA13,HCK,IGF1,PRKCD,SERPINB9,STAT6,THBD | NA |
| CD247 | -7.80e-01 | transmembrane receptor | Inhibited | -2.31e+00 | NA | 3.8e-01 | CYBA,EDIL3,FCER1G,HSP90AA1,KCNK3,MTHFD2,PLA2G5,QPCT,SMPDL3B,SRP14,TRA2A,UBE2L6 | NA |
| TARBP2 | -3.00e-02 | other | Inhibited | -2.32e+00 | NA | 0.0e+00 | DCAF6,MAF,MYH7B,MYL1,MYL3,PROS1,RET,SOX6,THBS1,TNNC1,TNNI2 | 917 (7) |
| 4-methylnitrosoamino-1-(3-pyridinyl)-1-butanone | NA | chemical toxicant | Inhibited | -2.32e+00 | NA | 0.0e+00 | ADAM17,ALOX5,ANXA1,BCL2L1,CDKN1A,EZH2,HOXA5,HTRA3,IKBKE,IL10RA,LCP1,LOX,NFE2L2,PTGES,PTGS2,SOCS3,SPP1,TBXAS1,TKT | 1245 (18) |
| cephaloridine | NA | chemical drug | Inhibited | -2.32e+00 | NA | 1.0e-02 | ADAT1,AMPD1,CCNE2,CSMD1,CXCL10,CXCL13,CXCL14,CYP1B1,DDIT4,E2F8,FBP2,G6PD,GPNMB,HSPA1A/HSPA1B,KNTC1,NUP93,OSMR,PEX13,PIR,POLA2,RAB31,RND1,STRA6,TPH1,USE1,ZNF367 | NA |
| UCP1 | 1.60e-01 | transporter | Inhibited | -2.32e+00 | NA | 0.0e+00 | ADGRE1,ALDH18A1,AMD1,ANKRD1,ARHGAP33,ARHGEF2,ASNS,BCAT2,BCKDHA,CASP3,CLCN3,CPNE2,CXCL10,DKK3,EEF1A1,EIF4EBP1,EMB,EML1,ESRRG,FBXO32,G6PD,GADD45A,GHITM,GOLM1,GPX3,GREM2,GSR,Hmgn2 (includes others),IRF3,LRRC8D,MAP1LC3A,MSS51,MTHFD2,MYH2,MYOG,OAS3,PHGDH,PHYHD1,RAB40B,REEP6,SERPINE1,SHMT1,SLC6A9,SMOX,SMTNL2,SMYD2,STBD1,STYX,TGFB1,TLR7,TPPP,TTLL7,UBC,UCP3 | 1173 (12) |
| APEX1 | 3.60e-01 | enzyme | Inhibited | -2.32e+00 | NA | 3.0e-02 | ALOX5,CDKN1A,EGR1,EGR2,EGR3,GFRA1,NR4A1,PTGS2,RGS2,RGS4 | NA |
| collagenase | NA | group | Inhibited | -2.32e+00 | bias | 0.0e+00 | Ccl2,Ccl7,CEBPD,CXCL10,CXCL12,EGR1,ICAM1,IER3,IL1R1,IRF1,ITGA4,PTX3,SELE,SELP,VCAM1 | 968 (11) |
| IFNL3 | NA | cytokine | Inhibited | -2.33e+00 | bias | 2.0e-02 | IFIH1,IFNLR1,IL2RA,MX1,RSAD2,SOCS1,STAT1,TLR2,TLR4,USP18 | NA |
| pyridaben | NA | chemical toxicant | Inhibited | -2.33e+00 | NA | 2.0e-01 | CACNA1E,CCL21,CEBPD,CEP290,INHBA,KCNA2,LAMC2,MBOAT2,NFAT5,NR4A1,ROCK1,STRBP | NA |
| HCAR1 | -9.90e-01 | G-protein coupled receptor | Inhibited | -2.33e+00 | NA | 1.0e-02 | COL1A1,CXCR4,EDN1,ICAM1,NEDD9,SEMA5A,SLC16A1,SLC16A3,SNAI1 | 923 (7) |
| BMP7 | -3.70e-01 | growth factor | Inhibited | -2.33e+00 | NA | 0.0e+00 | ACSL1,ACTA2,ACVR1,ADIPOQ,ADORA2A,BMP1,BMP4,CAV2,CD34,CD44,CDH1,CDH2,CDKN1A,CEBPD,COL1A1,COL5A2,CSRP2,CXCR4,CXXC5,DLK1,DUSP1,EDN1,ERBB3,Esrra,F3,FN1,FOXC2,GCH1,GLUL,GNG11,GREM1,HRAS,ICAM1,ID2,IGF1,IGFBP4,IGFBP5,IGFBP6,IL1RN,IRS1,ITGA5,JAG1,KLC1,KLF4,LOXL1,MADD,MAPK3,MC4R,MMP2,MSN,MYADM,NCAM1,OCLN,OLFM1,PENK,PIK3R1,PLCB1,PMEPA1,PPARG,PPARGC1B,PRDM16,RGS2,RUNX2,S100A4,SCTR,SERPINE1,SLC12A7,SMAD6,SMAD7,SOCS3,SOSTDC1,SOX10,SPP1,SPTBN2,STAR,TAGLN,TGFB1,TIMP1,TMEM132A,VCAN,VIM,WNT11,WNT5A,ZEB2 | 981 (17) |
| P2RY2 | -5.70e-01 | G-protein coupled receptor | Inhibited | -2.34e+00 | NA | 0.0e+00 | BCL2L1,Ccl2,CCND1,CDKN1A,ESM1,F3,FOXO1,GAP43,HAS2,HIF1A,ICAM1,NFE2L2,PTGS2,SERPINE1,VCAM1 | 1248 (16) |
| ALOX15 | -9.60e-01 | enzyme | Inhibited | -2.34e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ALOX15,AXIN2,Ccl2,CD36,FN1,ICAM1,IL17A,MMP2,PPARD,PPARG,RGS2,VCAM1 | 1091 (20) |
| ISLR | -1.32e+00 | other | Inhibited | -2.34e+00 | NA | 1.7e-01 | ANKRD1,CIART,DLG3,FSTL1,FZD1,FZD2,INHBA,MOB3A,SNAI2 | NA |
| FLT3LG | -8.40e-01 | cytokine | Inhibited | -2.35e+00 | NA | 0.0e+00 | ADGRE5,CCR5,CD83,CD86,CXCL12,CXCR4,CYBB,FCGR1A,FOXP3,ICAM1,ID2,IL15RA,IL1RL1,IL2RA,IL2RB,IRF8,MAP1LC3B,PTPRC,ROCK1,SCNN1G,SOCS1,SPN,TAL1 | 1187 (19) |
| PRKD1 | -6.70e-01 | kinase | Inhibited | -2.35e+00 | NA | 1.0e-02 | ADIPOQ,Ccl2,CCND1,CCND2,CD86,CKM,CXCL10,F3,GATA4,IL2RA,KDR,LPL,MMP2,MYF5,MYH2,MYOG,NR4A1,TNFRSF11B,UCP3,VCAM1 | NA |
| SASH1 | -4.90e-01 | other | Inhibited | -2.35e+00 | bias | 0.0e+00 | ARID5A,CCND2,CITED2,CXCL10,EDN1,FGL2,HDC,HHEX,IL15RA,INHBA,IRF1,ISG15,MET,NMI,OASL,PLA1A,PLAT,PTGS2,RBL1,RILPL1,RSAD2,SAP30,SLCO3A1,SOCS1,STAT1,TNFSF8 | 586 (7) |
| IL6R | 4.10e-01 | transmembrane receptor | Inhibited | -2.35e+00 | NA | 1.0e-02 | A2M,ABCC3,ACTA2,BCL2L1,CD36,CDK2,CDKN1A,COL1A1,COL2A1,CTSK,CXCL10,FN1,GREM1,ICAM1,IGF1,IGFBP5,IRF1,MMP2,PENK,PTGS2,SOCS3,TGFB1,TIMP1,TNFRSF11B,VCAM1 | 769 (12) |
| MAOA | 5.20e-01 | enzyme | Inhibited | -2.35e+00 | NA | 1.0e-02 | ACTA2,ALDH1A1,CCND1,CD44,CEBPD,HTR2A,SLC18A2,SOCS3,TGFB1,TNC,TWIST1,VIM | 1599 (23) |
| SEMA7A | 2.06e+00 | transmembrane receptor | Inhibited | -2.36e+00 | bias | 0.0e+00 | CCNA2,CD36,COL1A1,COL3A1,CTSS,EGR1,ELN,FGF2,FN1,SMAD6,SREBF1,TGFB1,TIMP1 | 1029 (14) |
| TNFAIP6 | -1.04e+00 | other | Inhibited | -2.36e+00 | NA | 1.0e-02 | ACTA2,CDH1,CDH2,CXCL12,MRC1,SNAI1,SNAI2,TNFAIP6,VIM | NA |
| HOTAIR | NA | other | Inhibited | -2.37e+00 | NA | 1.0e-02 | ACTA2,CDH1,CDH2,CDKN1A,CEBPD,COL1A1,HIF1A,ICAM1,JAM2,LAMC2,MMP2,MPZL2,MX1,NFKBIA,PPARG,SNAI1 | NA |
| CAMP | -3.00e-02 | other | Inhibited | -2.37e+00 | NA | 0.0e+00 | AHR,BCL2L1,BMP1,C5AR1,Ccl2,Ccl7,CD83,CD86,CSF1,CSF3R,CXCL10,CXCL13,CXCR4,EPHA3,FGF2,ICAM1,IL17A,IL1RL2,IL1RN,IRF8,ITGB2,NOTCH4,PTGS2,SNAI1,SNAI2,STAT1,TGFB1,TLR2,TLR4,TNFAIP2,VEGFC,XPA | 1098 (17) |
| hexamethylene bisacetamide | NA | chemical reagent | Inhibited | -2.38e+00 | NA | 4.1e-01 | BCL2A1,CDKN1A,FN1,IMP4,MAP2,RPL18,SNU13,USF2,WNT2B | NA |
| ERBB2 | -5.40e-01 | kinase | Inhibited | -2.38e+00 | NA | 0.0e+00 | ABHD5,ABRACL,ACKR3,ACTA1,ACTA2,ADAM17,ADAM19,ADAMTS5,AKAP12,ALOX15,ANGPT2,ANXA2,APLNR,ARHGEF5,ATF3,ATP6AP2,ATP6V1A,AXIN2,B3GALT6,BARD1,BCAT2,BCL2L1,BCL3,BHLHE40,BIRC3,BMP1,BTG2,BUB1,BUB1B,C3AR1,C5AR1,CBFA2T3,CCDC80,Ccl7,CCNA2,CCND1,CCND2,CCNE2,CCR3,CCR5,CCRL2,CD34,CD36,CD47,CD9,CDC14B,CDC25B,CDC42EP3,CDCA4,CDCA7L,CDH1,CDH11,CDH2,CDH3,CDK6,CDKN1A,CDKN2C,CDON,CENPF,CHD7,CHST10,CHST3,CLDN1,CLDN3,CLEC11A,CLEC3B,CNR1,COL18A1,COL1A1,COL3A1,COL5A1,COL5A2,COL6A3,COL7A1,CSF1R,CX3CR1,CXCL10,CXCL12,CXCL13,CXCR4,CXCR5,CYP4B1,DAAM1,DAP,DHH,DLL1,DPY19L3,DSE,DTX1,DUSP18,DUSP6,E2F2,E2F5,E2F7,E2F8,EBP,EDN1,EDNRB,EGR1,EIF4EBP1,EIF6,ELK3,ELL2,EMP1,EMP3,EPHB2,EPSTI1,ERAP1,ERBB3,ESPL1,ETV1,ETV5,EXT1,F2R,F2RL1,F2RL3,F3,FEN1,FGF9,FN1,FOXO1,FSCN1,FSTL1,FZD4,GBE1,GCNT2,GFPT2,GGT5,GINS3,GLO1,GLUL,GNAI1,GPAM,GPD2,GPX3,GXYLT2,H6PD,HAS2,HIF1A,HOMER2,HSPA1A/HSPA1B,HTR1B,ICAM1,ID2,IDH1,IGFBP4,IGFBP5,IGFBP6,IKBKB,IRF6,ITGA2,ITGA5,ITGA6,ITGB3,ITGB4,ITPK1,JAG1,JAM2,KDR,KIT,KLF4,KLHDC3,L1CAM,LAD1,LAMC2,LAMP2,LGALS1,LITAF,LPAR1,LPCAT1,LSR,LSS,LTBP2,LUM,MAF,MAN1A1,MAN2A1,MAP1B,MAPK4,MCM7,MCM8,MITF,MKI67,MLXIP,MME,MMP14,MRC1,MSLN,MYBL1,MYCN,MYL3,MYO10,NCAPG,NCF2,NDRG4,NDUFAB1,NDUFV1,NEDD9,NET1,NFKBIA,NID1,NNMT,NOTCH2,NOTCH4,NOX4,NPR1,NPR2,NPR3,NR2F1,NRP1,NUP210,OXTR,P2RY12,PDE8A,PDGFD,PDIA4,PDK4,PDLIM4,PENK,PER1,PFKFB3,PGK1,PGM1,PHGDH,PHLDB1,PLAT,PMEPA1,POLA1,POLA2,POLE4,POLR1B,POLR2E,PPARG,PPP2R2B,PRC1,PRIMA1,PROM1,PTAFR,PTGES,PTGS2,PTPRB,PTPRF,PTX3,RAB31,RARG,RECK,RFC2,RFC5,RPL17,RPS10,RRAD,RXFP1,RXFP2,S100A4,S100A6,SDC1,SERP1,SERPINE1,SFRP1,SHMT1,SIRPA,SKP2,SLC2A1,SLC7A1,SLCO4A1,SMAD7,SMC2,SNAI1,SNAI2,SNCA,SOWAHC,SPAG1,SPARC,SPDEF,SS18L2,ST3GAL1,ST3GAL6,ST6GAL1,STRBP,TAGLN,TCEAL9,TGFA,TGFB1,TGFBI,THBD,THBS1,THBS4,THSD1,THY1,TMEM106B,TMEM132A,TMEM43,TNC,TOP1MT,TOP2A,TP63,TPD52L1,TSPAN1,TUBA1A,TUBB4A,TWIST2,TYMS,UCK1,UGT8,UNC5B,UQCR10,USF2,VCAN,VEGFC,VEGFD,VIM,VWF,WNT5A,ZEB2,ZFP36L2 | 1507 (18) |
| CSF1R | -6.20e-01 | kinase | Inhibited | -2.38e+00 | bias | 2.0e-02 | ADGRE1,Adgre4,ARG1,CCND1,CCND2,CDKN1A,CSF1,CSF1R,FMOD,LGR5,MRC1,MSR1,VCAM1 | NA |
| CCN2 | NA | growth factor | Inhibited | -2.38e+00 | NA | 0.0e+00 | ACTA2,ADAMTS1,ADAMTS5,BCL2A1,BCL2L1,CCND1,CD44,COL1A1,COL2A1,COL8A1,DAD1,DCN,EGR1,FN1,FZD2,HIF1A,IGF1,IL17A,ITGA1,KITLG,LEF1,LIMS1,LOX,LOXL1,MMP14,MMP2,PDGFB,PI4K2B,PTGFR,SDC4,SERPINE1,SFRP4,SPARC,TGFB1,TIMP1,TMOD3,Tpm1,WNK1 | 1414 (17) |
| NOTCH2 | -6.90e-01 | transcription regulator | Inhibited | -2.38e+00 | NA | 8.0e-02 | ACTA2,CDH1,CNN1,COL1A1,DTX1,FN1,HEY2,IL1RL2,NOTCH2,PRAG1,SDC2,STAR,TAGLN,TSPAN33 | NA |
| Salmonella enterica serotype abortus equi lipopolysaccharide | NA | chemical toxicant | Inhibited | -2.39e+00 | bias | 0.0e+00 | ACKR3,ADRB2,ASNS,ATP1B1,BIRC3,Ccl2,CCRL2,CFB,DNAJB4,E2F7,EDN1,EGR1,EGR3,ELOVL7,EZH2,F3,G0S2,GADD45A,GADD45B,GJB2,HECW2,HOMER1,HS3ST3B1,ID2,IL15RA,IL2RA,INHBA,IRF1,ISG15,MAD1L1,MAFF,MBNL1,NEDD4L,NLRP3,NR4A2,OASL,OAZ2,PHLDA1,PIM3,PLA1A,PLD1,PTGS2,PTX3,RIPK2,SIAH2,SLAMF1,SLC1A3,SOCS3,TEX14,TFPI2,THBS1,TIFA,WNT5A | 1368 (16) |
| IFNA14 | NA | cytokine | Inhibited | -2.39e+00 | NA | 8.0e-02 | CXCL10,IFIH1,IFIT1,ISG15,MX1,RSAD2 | NA |
| oxysterol | NA | chemical - endogenous mammalian | Inhibited | -2.39e+00 | NA | 5.0e-02 | ABCA1,ABCG1,CAV1,Ccl2,TGFB1,TIMP1 | NA |
| MAP2K6 | 0.00e+00 | kinase | Inhibited | -2.40e+00 | NA | 0.0e+00 | ACP5,ACTA1,ACTA2,ATP2A2,BGN,BTRC,Ccl2,CCND1,CD83,CD86,CDKN1A,CKM,CRYAB,CXCL10,IRS1,IRS2,ISG15,MMP2,MYH6,MYH7,MYOD1,MYOG,NPR1,PLA2G2A,PRDX1,PTGS2,RGS7,SLC1A3,SNAI1,STAT1 | 1370 (23) |
| DSCAML1 | -3.00e-01 | other | Inhibited | -2.40e+00 | NA | 0.0e+00 | ARHGAP33,ETV5,FRK,GADD45G,JAK3,KCNA1,KCNA2,KLF4,KLF9,LGI1,MAP2,MICALL2,NGEF,NOS1,NRCAM,NTN4,NTNG2,NTRK2,OR51E2,PCDH17,PDGFB,PLCB1,PLD1,PLXNA4,PRKCB,ROBO2,SEMA3F,SEMA7A,SFRP1,SNCA,SNCAIP,SOX6,TUBB4A,UNC5A | NA |
| BCAP31 | 4.50e-01 | transporter | Inhibited | -2.40e+00 | NA | 0.0e+00 | ADGRE1,ARG1,Ccl2,CD9,COL1A1,CXCL10,EDEM1,EGR2,FGF2,FN1,HACD2,IRF1,IRF6,MRC1,PDGFB,RTN3,SREBF1,VCP | 898 (12) |
| MRS 1754 | NA | chemical reagent | Inhibited | -2.40e+00 | bias | 0.0e+00 | CD86,CIITA,HLA-DRA,MMP2,TGFB1,TIMP1 | 659 (7) |
| IL11RA | 5.30e-01 | transmembrane receptor | Inhibited | -2.40e+00 | NA | 2.0e-02 | ACTA2,Ccl2,Ccl6,Ccl7,DUSP5,FOXP3,HGF,HIF1A,ICAM1,KLF5,MMP2,SELP,SOCS3,TGFB1,TIMP1 | NA |
| NOX1 | -1.38e+00 | enzyme | Inhibited | -2.41e+00 | NA | 1.5e-01 | F3,KDR,NFKBIA,NOX1,SMAD7,TGFA | NA |
| Tlr | NA | group | Inhibited | -2.41e+00 | NA | 1.0e-02 | ARG1,BCL6,Ccl2,CD83,CD86,CISH,CXCL10,DUSP1,GNAI3,GPR34,HLA-A,ICAM1,ID2,IL33,IRAK3,IRF1,IRF4,JAG1,NFKBIA,NOTCH2,PTGS2,RGS14,RGS18,RGS20,SEMA3A,SIGIRR,SOCS1,SOCS3,SPHK1,STAT1,WNT5A | 1395 (14) |
| F10 | -2.40e-01 | peptidase | Inhibited | -2.41e+00 | bias | 2.0e-02 | EGR1,F3,ICAM1,MMP2,SELE,VCAM1 | NA |
| IL3 | NA | cytokine | Inhibited | -2.41e+00 | NA | 0.0e+00 | ADGRE1,ADGRE5,APBA2,ARG1,ARHGAP29,ARHGDIB,BCL2L1,BCL2L11,BIRC3,BTG2,Calm1 (includes others),CASP3,CBFB,Ccl6,CCND1,CCND2,CCR3,CD48,CD53,CD83,CD86,CDKN1A,CISH,CITED2,CLEC11A,CREM,CSF1,CSF1R,CXCR4,DAD1,DOK2,ECH1,EEF1A1,EGR1,EGR2,EGR3,EIF3G,EMP3,F2R,FCGR2B,FGFR1,GADD45A,GADD45B,GADD45G,GNA13,GNAS,HBA1/HBA2,HGF,HK1,HLA-A,HSPA2,HUS1,ICAM1,IL1RL1,IL2RA,IL33,ITGB3,ITGB7,KLF9,LY75,LYN,MID1,MS4A2,Mt1,NCF1,NEDD9,NFATC3,NRP1,PAPPA2,PDPN,PHGDH,PLA2G7,PPP5C,PROX1,RANBP1,RIDA,Rnf113a1,RPL6,RPS16,RPS3,SELE,SEMA7A,SLC2A1,SOCS1,SOCS3,SSBP1,STT3A,TAL1,TLR2,TLR4,TNFRSF4,TNFSF8,Ubb,USF2,VAV2,VCAM1,WNK1 | 924 (19) |
| ANXA2 | -1.05e+00 | other | Inhibited | -2.41e+00 | NA | 3.3e-01 | CDK6,CDKN1A,GADD45A,MMP2,PTGS2,S100A10,SESN1 | NA |
| PLAT | -6.90e-01 | peptidase | Inhibited | -2.41e+00 | NA | 3.0e-02 | BDNF,CCND1,CXCL10,FN1,GFAP,INHBA,MMP2,PLAT,SERPINE1,TGFB1,TLR4 | NA |
| NTF4 | 3.50e-01 | growth factor | Inhibited | -2.41e+00 | NA | 4.0e-02 | GAP43,NTRK2,PENK,SPARC,SPP1,TUBA1A | NA |
| mir-3622 | NA | microRNA | Inhibited | -2.41e+00 | NA | 4.0e-02 | CCND1,CCND2,CDKN1A,GADD45A,GADD45B,SESN1 | NA |
| GATA6 | -6.90e-01 | transcription regulator | Inhibited | -2.42e+00 | NA | 0.0e+00 | ACTA2,ACTC1,ALOX15,AMHR2,ARG1,ASPA,BMP4,BMP5,C1R,Cald1,CAV1,CDKN1A,CRYL1,CXCL13,DAB2,DLK1,DPP4,ECSIT,EDN1,EMX2,ESPL1,ESRRB,FGF2,GATA4,GPI,HBA1/HBA2,HYAL1,IRF6,IRF8,LDHB,LGR5,LTBP1,MC2R,MRC1,MYH6,MYH7,NDUFA1,NR5A2,PDGFRA,PGK1,PIK3C2G,PPARG,PRDM1,PTGES,PTGIS,RBPJL,SEMA3C,SLC9A3,SORBS3,SOX7,SPARC,STAR,STARD13,TAGLN,TBX3,TGFB1,TNNC1,VEGFC,WNT2 | 1220 (20) |
| KDM6A | NA | enzyme | Inhibited | -2.42e+00 | NA | 2.4e-01 | ARHGDIB,CFI,COL1A1,CSPG4,ENO3,ICAM1,IGFALS,IRAK3,KCNJ13,SELE,VCAM1 | NA |
| carrageenan | NA | chemical drug | Inhibited | -2.42e+00 | bias | 2.0e-02 | Ccl2,EGR1,EGR2,F2RL1,GFAP,ICAM1,JUND,KIT,NFKBIA,PTGES,PTGS2,SELENOP,SELP,TRPM2,WNT9A | NA |
| NRTN | 8.20e-01 | growth factor | Inhibited | -2.42e+00 | NA | 8.0e-02 | ASIC2,EGR1,EGR2,GAD1,PENK,RET | NA |
| OLR1 | 1.48e+00 | transmembrane receptor | Inhibited | -2.42e+00 | NA | 0.0e+00 | CYBA,CYBB,FN1,HAS2,HAS3,ICAM1,NCF1,NCF2,NOX4,OLR1,RARA,RARG,RXRA,RXRG,SELP,SPP1,STRA6,TGFB1,VCAM1 | 1107 (20) |
| FCGR2A | NA | transmembrane receptor | Inhibited | -2.42e+00 | NA | 1.0e-02 | Ccl2,CXCL10,F2RL1,FCGR3A/FCGR3B,GBP2,ICAM1,IFITM3,IP6K2,ISG15,MARCKSL1,OAS3,PTGS2,RASGRP1,SERPINE1,STAT1,USP18 | NA |
| PDGFC | -6.00e-01 | growth factor | Inhibited | -2.42e+00 | bias | 0.0e+00 | ACTA2,CCND1,FGF2,GFAP,KDR,NR4A1,PDGFRA,SNAI2,TEK,TGFB1,TIMP1 | 1342 (20) |
| AMH | -1.50e-01 | growth factor | Inhibited | -2.42e+00 | NA | 0.0e+00 | ACVR1,BTG2,CDKN1A,CEACAM1,IER3,INHA,IRF1,MMP2,RBL1,SMAD6,SMAD9,STAR | 1266 (21) |
| ACVR2A | 1.10e-01 | kinase | Inhibited | -2.42e+00 | NA | 1.0e-02 | DMP1,ICAM1,ID2,INHBA,SELE,VCAM1 | 846 (9) |
| IFNL2 | NA | other | Inhibited | -2.42e+00 | NA | 3.0e-02 | CCR5,CXCL10,CXCR4,IFIT1,MX1,RSAD2 | NA |
| vitamin K2 | NA | chemical drug | Inhibited | -2.42e+00 | NA | 8.0e-02 | CSF1,DSE,MATN2,SPP1,TNFRSF11B,TSKU | NA |
| GCK | 6.30e-01 | kinase | Inhibited | -2.42e+00 | NA | 3.8e-01 | CCND2,CDH1,IRS2,PDK2,Scd2,SREBF1 | NA |
| HOXA9 | 3.10e-01 | transcription regulator | Inhibited | -2.43e+00 | NA | 0.0e+00 | ADD3,ALDH1A1,ARF1,ARL3,BCL2L11,BRCA2,CALB1,CALCRL,CBX6,CD34,CD36,CD93,CDH1,CDK17,CELF2,CISH,CLCN7,CLIC2,CREB1,CREM,CYBB,DHX36,FCGRT,FZD1,FZD5,GLRX,GNG10,GPR183,HNRNPU,HOXD10,ID2,IGF1,ITGBL1,KIT,LAT2,LY86,LYN,MAN2A1,MBNL1,MSI2,NDUFB3,NEB,PTPRC,RAB31,RCBTB2,RDX,RGL1,RPL37A,SDC4,SELE,SERPINB9,SLC27A6,SPNS2,SPP1,USP1,VIM,WNT10B,WSB1 | 750 (7) |
| HMGB1 | NA | transcription regulator | Inhibited | -2.43e+00 | NA | 0.0e+00 | CASP3,CD83,CD86,CDKN1A,CKM,EGR1,GFAP,GLUL,HIF1A,HOXD9,ICAM1,IFIT1,IL17A,IL1R1,IRF5,IRS1,MIA,MRC1,MX1,MYOG,PLA2G2A,PTGES,PTGS2,SELE,SMAD7,SREBF1,SYP,TLR2,TLR4,VCAM1 | 1186 (14) |
| HJURP | -5.80e-01 | other | Inhibited | -2.43e+00 | NA | 0.0e+00 | CCND1,CDK6,CDKN1A,SNAI2,VIM,WEE1 | 1246 (13) |
| OXT | NA | other | Inhibited | -2.43e+00 | NA | 0.0e+00 | ACTC1,Cox8b,CREB1,GATA4,LPL,MYH6,MYH7,MYL2,OXTR,PRKCZ,PTGS2,RGS2 | 1487 (26) |
| epoprostenol | NA | chemical - endogenous mammalian | Inhibited | -2.43e+00 | NA | 1.0e-02 | EGR1,HIF1A,PTGIS,PTGS2,RGS18,SERPINE1,SPP1 | 1246 (16) |
| RALA | 4.30e-01 | enzyme | Inhibited | -2.43e+00 | NA | 2.0e-02 | CDH1,CDH2,CDKN1A,MMP2,SNAI1,VEGFC | NA |
| YWHAQ | -9.60e-01 | other | Inhibited | -2.43e+00 | NA | 3.0e-02 | CASP3,CASP8,CDKN1A,CNN1,ETV1,TAGLN | NA |
| isobutylmethylxanthine | NA | chemical toxicant | Inhibited | -2.44e+00 | NA | 0.0e+00 | ABCA1,ACSL1,ACSL3,ADIPOQ,APLN,BDNF,CALCR,CAV1,CAV2,Ccl2,CCND1,CCNE2,CD34,CD36,CD44,CDK2,CDKN1A,CEBPD,COL1A1,COL3A1,COL5A1,COX4I1,Cox8b,CREB1,CREM,CXCR4,EGR1,EGR2,ENC1,FAM89B,FN1,GAPDH,GCGR,IDH1,IL17A,IL2RG,INHBA,ITGA1,ITGA3,ITGB2,ITGB3,KLF4,LGALS12,LPL,MAPK3,MITF,MMP2,Mt1,NDUFV1,PDE3B,PDE4D,PDGFRA,PDK4,PITX3,PLAT,PLIN1,PPARD,PPARG,PTGFRN,RAB7A,RBL1,RETN,RXRA,Scd2,SERPINE1,SGK1,SNAI1,SREBF1,STAT1,SYK,SYP,TGFB1,THBS1,THBS2,TIMP1,TNC,TPD52L2,TRPV1,TUBB,TYRO3,WNT10B | 1730 (23) |
| SMAD5 | -9.00e-02 | transcription regulator | Inhibited | -2.44e+00 | NA | 0.0e+00 | CSF1,CSF2RA,GFAP,ICAM1,ID4,PDGFB,RUNX1,RUNX2,SELE,SERPINE1,SMAD6,VCAM1 | 1374 (19) |
| GnRH analog | NA | biologic drug | Inhibited | -2.44e+00 | NA | 0.0e+00 | ACOT7,ACTN4,AQP7,ARHGEF10,ARHGEF9,ATF3,ATP6V1E1,BCL2A1,BCL3,BHLHE40,CACNA1D,CADM4,CASP3,CASP8,CENPF,CETN2,CHMP2A,CUX1,CYTH1,DUSP1,DVL1,DYNLL1,EDNRB,EGF,EIF4EBP1,ESRRG,FADD,FBLN5,FCGRT,FGF2,FLT3LG,FN1,GAB1,GPSM2,HIF1A,HINT1,HSPA2,INHBA,L3MBTL1,LCAT,LIMS1,MAP2,MAP2K4,MAPK3,MFAP5,MICU1,MKI67,MYO7A,NADK,NCBP2,NDUFS7,NDUFV2,NFKBIA,NR4A2,NTRK2,PCNT,PIK3R3,POLR2E,PPIA,PRCP,PSMA6,PSMD13,RAB8A,RALGPS1,RARA,RASSF2,RELN,SFRP1,SKAP2,SLC25A44,SLC7A6,SNX3,SOX10,SRSF3,TAF1C,TNK2,TPBG,TUBA1A,TWF1,UBAC1,UBE2D3,UBE2M,UCN,VAT1,VCP | 592 (7) |
| monocrotaline | NA | chemical toxicant | Inhibited | -2.44e+00 | NA | 0.0e+00 | ATP2A2,BCL6,Ccl2,CCND1,CMKLR1,CNNM2,CYBB,FHL1,GADD45A,GAP43,MMP2,MYH7,NCAM1,NOX1,PDGFB,PPIA,SLC41A2,Slc41a3,SLC9A1,SMAD6,SMAD9,SPP1,ZDHHC17 | 1241 (18) |
| SMAD2 | 3.10e-01 | transcription regulator | Inhibited | -2.45e+00 | NA | 0.0e+00 | ACTA2,ACVR1C,BCL2L11,BGN,CACNA1D,CDH1,CDH2,CDKN1A,COL2A1,COL3A1,DAPK1,ESM1,FN1,FOXP3,GADD45B,GZMB,HAS2,HHEX,IGF1,INPP5D,MAFA,MET,MMP2,MYF5,NET1,PDGFB,PTX3,RUNX2,SELE,SERPINE1,SFTPB,SMAD7,SNAI1,SNAI2,SPHK1,THBS1,VEGFC,VIM | 1432 (16) |
| NLGN1 | -6.00e-01 | enzyme | Inhibited | -2.45e+00 | bias | 0.0e+00 | CCND1,CDH2,L1CAM,LAMC2,MMP2,TWIST1 | 1151 (9) |
| AXL | -1.24e+00 | kinase | Inhibited | -2.45e+00 | NA | 2.7e-01 | CDH1,CDH2,IL17A,MMP2,SNAI1,SNAI2,TWIST1,VIM | NA |
| IDH1 | -1.04e+00 | enzyme | Inhibited | -2.45e+00 | NA | 0.0e+00 | ABCA1,ABCG1,BCAT1,CD47,CDH1,CLDN3,CREB3L1,EDEM1,EGR1,FBP2,FN1,GLI1,HERPUD1,KDM4B,LPL,MX1,MYLIP,PGK1,PPARG,PTCH1,RETN,RUNX2,SERPINH1,SLC2A1,VIM,ZEB2 | 1578 (21) |
| OTUD1 | -1.31e+00 | peptidase | Inhibited | -2.45e+00 | NA | 0.0e+00 | ACTA2,COL1A1,SNAI1,TGFB1,TWIST1,VIM | 1041 (17) |
| GPX8 | -1.48e+00 | enzyme | Inhibited | -2.45e+00 | bias | 0.0e+00 | CD44,CDH11,CXCL10,FN1,ITGB4,SNAI2 | 654 (7) |
| triclosan | NA | chemical drug | Inhibited | -2.45e+00 | NA | 1.0e-02 | ACTA2,COL1A1,CYBB,MBD3,NCF1,NCF2,TIMP1 | NA |
| IFNK | NA | cytokine | Inhibited | -2.45e+00 | NA | 7.0e-02 | CD83,CD86,CXCL10,IFIH1,IRF1,MX1,STAT1 | NA |
| MR-409 | NA | chemical reagent | Inhibited | -2.45e+00 | NA | 8.0e-02 | C8orf44-SGK3/SGK3,CALCR,CCL24,CREB5,F2R,RHOA | NA |
| SNAI1 | -6.20e-01 | transcription regulator | Inhibited | -2.46e+00 | NA | 0.0e+00 | ADIPOQ,AFAP1,ANKRD1,AXL,BCL2L1,BMP4,BMP5,CCND1,CCND2,CD44,CDC25B,CDH1,CDH2,CDK2,CDKN1A,CFL1,CFL2,CGN,CLDN1,CLDN3,COL1A1,COL2A1,CUX1,CXADR,DDR2,DPYSL3,ELF4,ERCC1,F3,FLNA,FMNL2,FN1,FOXC2,GFAP,GLI1,GLI2,ID4,IL7,INHA,ITGA2,L1CAM,LASP1,LEF1,LIMA1,MMP14,MSI1,MYO5A,OCLN,PEBP1,PTGS2,PTX3,RUNX2,SDC1,SERPINE1,SERPINH1,SMAD6,SMAD7,SNAI1,SNAI2,SPARC,TGFB1,THBD,THY1,TMOD1,TMOD3,TP63,TWIST1,VIM,WIPF1,ZEB2 | 1518 (20) |
| PARP2 | -1.30e-01 | enzyme | Inhibited | -2.46e+00 | NA | 2.0e-02 | ADIPOQ,CCR5,CD36,CD83,CD86,CXCL13,LPL,PPARG,SFTPB | NA |
| HAS2 | -2.66e+00 | enzyme | Inhibited | -2.46e+00 | NA | 0.0e+00 | ACTA2,Ccl2,CD44,CDH2,DNAJB1,HSPA1A/HSPA1B,LOX,PDPN,PROX1,TGFB1,TIMP1,TNFAIP6,VIM | 1374 (17) |
| tetracycline | NA | chemical drug | Inhibited | -2.46e+00 | NA | 2.0e-02 | AK4,AUH,BCKDHA,BHLHE40,CA3,COL1A1,CSF1,ITGAE,JAG1,MAL,MRPS12,PCDH18,PPP1R3C,PTPN7,RPL23,SEMA6D,SERPINE1,SLC1A4,SPTLC3,TUT1 | NA |
| WNT11 | -8.70e-01 | other | Inhibited | -2.46e+00 | NA | 0.0e+00 | DMP1,ENO2,GATA4,MYF5,MYF6,MYH6,MYH7,MYOD1,MYOG,RHOA,THBD,TNNC1,TNNT2 | 1313 (18) |
| levothyroxine | NA | chemical - endogenous mammalian | Inhibited | -2.46e+00 | NA | 1.2e-01 | ACP5,ADIPOQ,ATP2A2,CDK14,CDKN1A,DIO1,EGF,IGFBP4,IGFBP6,ITGB3,Mbp,MYH6,PENK,SEMA3C,SFRP2,SREBF1,TRHDE | NA |
| NKX2-5 | NA | transcription regulator | Inhibited | -2.47e+00 | NA | 2.0e-02 | ACTA2,ANKRD1,GATA4,GJA5,HOPX,IFI16,MYCN,MYL2,MYOCD,NR5A2,PITX2,SCN5A,TBX5 | NA |
| TGFB2 | 2.70e-01 | growth factor | Inhibited | -2.47e+00 | NA | 0.0e+00 | ABCA1,ACTA2,AHR,ALDH1A1,BHLHE40,BMP4,CD36,CD86,CDH11,CIITA,CNN1,COL1A1,COL3A1,EDN1,EGR1,EGR2,FGF2,FMOD,FN1,HAS2,ID4,INHBA,JAG1,JAM2,KDR,LIPG,MIA,MMP2,OSR1,PDK4,PLOD2,PTAFR,RUNX1,RUNX1T1,SERPINE1,SESN1,SNAI2,SPHK1,SPP1,TAGLN,TGFB1,THBS1,TIMP1,TMEFF1,TNFRSF11B,VCAN,VIM,WNT11,WNT9A | 1484 (17) |
| RAC1 | -2.80e-01 | enzyme | Inhibited | -2.47e+00 | NA | 0.0e+00 | ACP5,ACTA2,ANKRD1,ATF3,BCL2L1,BCL6,Ccl2,CCND1,CD86,CDH1,CDH2,CIITA,CKM,COL2A1,CRP,DPYSL2,DUSP1,FGF2,FN1,FOXO1,HIF1A,ICAM1,IL33,ITGA6,KLF4,MAFA,MMP14,MMP2,MYH7,MYOG,PROM1,PTGS2,RHOA,SNAI2,SOX6,STAT1,TGFB1,VCAM1,WNT5A | 1180 (13) |
| prostaglandin D2 | NA | chemical - endogenous mammalian | Inhibited | -2.48e+00 | NA | 0.0e+00 | AHR,ALOX15,CCND1,CD44,CSF1,CXCL10,EDARADD,ENPP3,HAS2,HAS3,HSPA1A/HSPA1B,MYADM,NINJ1,NRP1,PHLDB1,PPARG,PRDM1,PRKCD,PTGS2,RXRA,SDC4,SOX8,TNFRSF11B | 1426 (20) |
| ICAM1 | -1.50e+00 | transmembrane receptor | Inhibited | -2.48e+00 | NA | 0.0e+00 | ACTA2,CD86,CDH2,COL8A2,ICAM1,IL17A,IL2RA,ITGA4,ITGAL,KLF4,PROM1,RHOA,SNAI1,SNAI2,SREBF1,TGFB1,VCAM1,VIM,ZEB2 | 956 (17) |
| Tgf beta | NA | group | Inhibited | -2.48e+00 | NA | 0.0e+00 | ABCA1,ACKR2,ACTA2,ADGRE5,ADH1C,AHR,ALDH1A1,ALDOA,ARHGAP45,ARID3B,ARID3C,ARNT2,ASGR2,ATP1B1,AXL,BACH1,BAMBI,BCL2L1,BGN,BHLHE40,BLVRB,CALCR,CASP1,CASP8,Ccl2,CCND1,CCND2,CD300LB,CD36,CD53,CDH1,CDH11,CDH2,CDK2,CDK6,CDKN1A,CHST11,CIITA,COL12A1,COL1A1,COL3A1,COL5A1,COL7A1,CSF1,CSF1R,CTSK,CX3CR1,CXCL10,CXCR4,CYBB,DAB2,DCN,EDN1,EGR2,EID2,ENG,ENTPD1,FGF10,FGF2,FN1,FOXP3,FSCN1,FSTL1,GADD45B,GCLC,GLI2,GREM1,GZMB,HEY2,HIF1A,HIF3A,HSP90AA1,ID2,ID4,IGF1,IGFBP4,IGFBP5,IL16,IL1RN,INPP5D,ITGA1,ITGA2,ITGA5,ITGA6,ITGB3,JAG1,KLF10,LAMA3,LCAT,LEPR,LMCD1,LOX,LOXL1,LOXL2,MAD2L1BP,MADD,MAF,MAX,MET,MID2,MITF,MLXIP,MMP14,MMP15,MMP2,MYCN,MYCT1,MYF5,MYOD1,MYOG,NCOR2,NEDD9,NFAT5,NOX4,NPAS2,NR4A1,NR4A2,PC,PDGFB,PFKFB4,PGK1,PHLDB1,PLAT,PLPP3,PMEPA1,PRELID2,PROM1,PTGS2,RUNX1,RUNX2,SDC1,SEC14L2,SELE,SERPINE1,SERPINH1,SGK1,SIM1,SLIT3,SMAD6,SMAD7,SMAD9,SNAI1,SNAI2,SOCS3,SPARC,SPP1,SREBF1,SSBP3,TAGLN,TCF15,TCF23,TGFA,TGFB1,TGFBI,THBS1,TIMP1,TLR2,TMEM252,TNFRSF11B,TWIST1,TWIST2,USF2,VCAM1,VIM | 1597 (17) |
| TREM2 | NA | transmembrane receptor | Inhibited | -2.49e+00 | NA | 0.0e+00 | ACTR3B,ARG1,AXL,B2M,BAMBI,Ccl2,CD36,CD86,CITED2,CSF1,CST7,CTSE,CX3CR1,FGF2,HIF1A,HLA-A,IRF8,LGALS1,LOX,LPL,MAMDC2,MAPK14,NFKBIA,NINJ2,P2RY12,PPARG,PTGS2,SULF2,SYP,UGT8 | 1293 (16) |
| FGF10 | -1.05e+00 | growth factor | Inhibited | -2.49e+00 | bias | 0.0e+00 | ANXA1,ANXA2,BMP4,CTSH,CYP1B1,IL10RB,LSS,MMP14,MYH6,MYH7,NKX6-1,PTGS2,S100A13,S100A6,SNAI1,TGFB1,TMEM123,TMOD3,TSPAN8 | 1564 (22) |
| CYBB | -1.70e+00 | enzyme | Inhibited | -2.50e+00 | NA | 1.0e-02 | Ccl2,CDKN1A,COL3A1,CXCL10,CXCL12,CYBA,CYBB,DUOX2,DUSP1,ICAM1,KIT,PPARG,PTGS2 | 1045 (14) |
| phorbol esters | NA | chemical - other | Inhibited | -2.50e+00 | NA | 8.0e-02 | ANXA1,B2M,BCAR1,CD44,CDH2,DUSP1,EGR1,ERCC1,HOXA5,HSD17B4,IL1R1,IL2RA,ITGAD,PLAT,PRKCB,PTGS2,PTPRO,REL,SLC9A3,TGFB1,TIMP1 | NA |
| Ifn gamma | NA | complex | Inhibited | -2.50e+00 | NA | 0.0e+00 | BCL2L1,CASP1,CASP3,Ccl2,CD86,CDKN1A,CHI3L1,CXCL10,CXCL16,CYBB,EDN1,HLA-DRA,ICAM1,IFI44L,IGFBP4,IGFBP5,IL17RA,IL18BP,IL33,IRF8,MYH7,NR4A3,PCDH7,PPARG,SOCS1,SOCS3,SOCS7,STAT1,TLR4 | 1140 (15) |
| lysophosphatidylinositol | NA | chemical - endogenous mammalian | Inhibited | -2.50e+00 | bias | 0.0e+00 | ANGPT2,C3,CASP1,CD36,CD74,CFB,CNR1,CX3CL1,F3,GLUL,ICAM1,IL33,ITGA1,OLR1,SELE,TNFRSF4 | 1298 (13) |
| MAP2K1 | 6.00e-02 | kinase | Inhibited | -2.51e+00 | NA | 0.0e+00 | ACTA2,AHR,ANKRD1,ASGR2,ATF3,AXIN2,BCL2A1,BCL2L1,BCL2L11,BIRC3,CCNA2,CCND1,CD44,CDK2,CDKN1A,CKM,COL1A1,COL3A1,CRP,CRYAB,DAB2,DPP4,DUSP1,DUSP5,DUSP6,EGR1,EGR2,EMP1,ENO2,ERRFI1,ETV5,F2R,F3,FGF2,FLNA,GADD45B,GLI2,HDC,HIF1A,IER3,IRS1,ITGA2B,ITGA5,ITGB3,ITGB4,JUND,LEF1,MAG,MAOB,MITF,MMP14,MMP2,MOG,MPZ,MYCN,MYH2,NET1,NFKBIA,NOS1,PDGFRA,PHLDA1,PLA2G4A,PLP1,PMP2,PTGS2,RAB38,RAP1GAP,RUNX2,SEMA7A,SIRPA,SLC20A1,SNAI2,SPDEF,STAR,TFPI2,TGFB1,THBD,THBS1,TM4SF1,TNC,TNFRSF10A,TRIB1,TWIST1,UBC,UNC5B | 1560 (17) |
| BTK | -1.35e+00 | kinase | Inhibited | -2.51e+00 | NA | 1.0e-02 | BCL2A1,BCL2L1,BTK,CCND2,CD86,CDK2,CDK6,CDKN1A,CISH,CXCL10,CXCR4,EMP1,ENPEP,ETS1,FOXO1,IFI44L,IFIT1,IL10RA,IL2RA,IL4I1,IRF1,IRF4,ISG15,ITGB3,MTHFD2,MX1,OAS3,RP2,SELP,SPN,STAT1 | 1361 (14) |
| hyaluronic acid | NA | chemical - endogenous mammalian | Inhibited | -2.52e+00 | NA | 0.0e+00 | ACKR3,BCL2L1,BCL3,Ccl2,CD44,CD83,CD86,COL2A1,CSF1R,CTSK,CXCL10,CXCR4,FN1,FOXP3,FRK,HOXD10,ICAM1,IRAK3,IRF5,MET,MMP2,NCF1,NCF2,NFKBIA,NR4A1,NR4A2,PDPN,PPARG,PROX1,PTGES,PTGS2,PTPRC,RHOA,SERPINE1,SOCS3,SPHK1,SPP1,TGFB1,TIMP1,TLR2,TLR4,VCAM1 | 1063 (14) |
| ID1 | -2.90e-01 | transcription regulator | Inhibited | -2.52e+00 | NA | 1.0e-02 | ALDH1A1,BCL2L1,CCND1,CDKN1A,CEACAM1,DTX1,EGR1,FN1,ICAM1,IFI16,MMP14,MMP2,MYF5,MYF6,MYOD1,MYOG,PROM1,RUNX2,SNAI1,THBS1,TYMS,VIM | 1475 (21) |
| valproic acid | NA | chemical drug | Inhibited | -2.53e+00 | NA | 0.0e+00 | AACS,Abca8a,ABCG1,ABHD5,ADRM1,AGPAT1,ALOX12,AMPD3,ANTXR2,ATF3,ATP2B4,B4GALT1,BCL2L1,BCL2L11,BDNF,Bmyc,C1QTNF6,C8orf44-SGK3/SGK3,CA12,CASP3,CASP8,CCND1,CCND2,CCR1,CD36,CD44,CD83,CDH1,CDKN1A,CHKA,COLQ,CRHR2,CRYL1,CXADR,CXCR4,CYP1B1,CYP39A1,DAPK3,DHCR7,EDEM1,EDN1,EIF2AK3,ELF1,FABP1,FAM107A,FOXC1,FSCN1,GADD45B,GAP43,GFAP,GINS3,GLUL,GPAM,GPX7,GZMB,H6PD,HDAC7,HERPUD1,HIF1A,HOMER1,HSD3B7,ICAM1,ID2,IL1RL1,ITM2C,JUND,KIT,LIMA1,LMO1,LRAT,MAD1L1,MGAT2,MICB,MME,MSMO1,MVD,MVK,MYCN,MYH3,MYOF,NAA10,NARF,NCAM1,NFATC2IP,NFYA,NR0B2,NRG4,P3H2,PDGFB,PKIB,PLAT,PLTP,PNPLA2,PNPLA3,PPARG,PRAG1,PRKCD,PRKCZ,PRKD1,PSMA4,PSMA6,PSMB1,PSMB5,PSMC1,PSMC5,PSMD13,PTGS2,PTX3,RARA,RERG,RNF144A,RNPEP,S100A4,SEL1L3,SELENOP,SEMA3C,SERP1,SERPINE1,SERPINH1,SGK1,SIAH2,SIRT7,SLC1A1,SLC35D1,SLC7A8,SMAD9,SPP1,SREBF1,SRSF1,STAR,Tcf7,TES,TGFB1,THBS1,TMEM164,TMEM260,TNFRSF10A,TNK2,TOP2A,UTRN,WNT5A,ZNRF1 | 1848 (21) |
| CYP19A1 | -3.00e-02 | enzyme | Inhibited | -2.53e+00 | NA | 0.0e+00 | ACADL,AMIGO2,B3GNT5,BDNF,CCND1,CD44,CXCL10,EGF,FAM107A,FGF2,FKBP5,GBP2,GFAP,HLA-A,HOMER1,IGF1,IRS1,LPL,NR5A2,OSMR,PPARG,PTGS2,PTX3,S100A10,SYP,TGFA,TGFB1,TIMP1,TM4SF1 | 1454 (20) |
| PARPBP | -1.81e+00 | other | Inhibited | -2.53e+00 | NA | 0.0e+00 | AMD1,COL8A1,ELN,EMB,IDH3G,PLOD2,SPON1,TIMP1,TNC,TST | NA |
| TRADD | -6.40e-01 | other | Inhibited | -2.53e+00 | NA | 2.0e-02 | BCL2A1,CX3CL1,ICAM1,IL18R1,IRF1,NFKBIA,RIPK2,RND1,TNFAIP2,VCAM1 | NA |
| IFNE | NA | cytokine | Inhibited | -2.53e+00 | NA | 9.0e-02 | CD83,CD86,CDKN1A,CXCL10,IFIH1,IFITM3,ISG15,PTGS2,SLC2A1,STAT1,USP18 | NA |
| allopurinol | NA | chemical drug | Inhibited | -2.53e+00 | NA | 0.0e+00 | A2M,A3GALT2,ADAMTS1,ANXA1,ANXA2,ASNS,ATP6AP2,BDNF,Bex2/LOC100912195,BIRC3,CD44,CP,CXCL10,EMP3,F3,FABP1,FBLIM1,GCGR,GPNMB,IER3,ITGB4,LAMC2,MRC1,PLA1A,PTGS2,S100A10,S100A11,SLC2A1,SLC9A3,SPP1,TES,TIMP1,TLR4,TMSB10/TMSB4X,Tpm1,TSPAN8,TUBB,VIM | 1319 (16) |
| ADAMTS18 | -6.60e-01 | peptidase | Inhibited | -2.53e+00 | NA | 0.0e+00 | CDH3,COL4A6,COL8A1,FBLIM1,ITGA3,ITGB4,ITGB7,LAMA3,LAMC2,LTBP2,MMP15,SCUBE3,SDK2 | NA |
| S100A9 | -6.00e-01 | other | Inhibited | -2.54e+00 | NA | 0.0e+00 | A2M,ABCG1,ADAMTS1,ADAMTS5,AKAP12,ALDH1A1,APLN,ATF3,BACE2,BCL3,BHLHE40,C3,CASP1,Ccl2,Ccl7,CCND1,CCNE2,CDH3,CORO1A,COX6A2,CP,CSF2RB,CSTF1,CXCL10,CXCL14,DDIT4,ELN,EPB41L4B,ETV5,FBLIM1,GJB2,GPR37L1,GZMB,HEY2,ICAM1,IGF1,IL1RL1,IL33,ISG15,ITGB4,KLF15,LTBP1,MAG,MMP14,MMP2,MYCT1,MYH8,NR4A3,OLR1,PDGFC,PER1,PHLDA1,PLK3,PLXNB3,PRSS12,PTGES,PTPRO,ROBO2,RXRG,SCUBE1,SEMA3B,SGK1,SIX1,SOCS3,SOCS7,TNFAIP8,TNFRSF4,TUBA8,UNC5A,USP18,VCAM1,VCAN | 946 (16) |
| KMT2A | -4.30e-01 | transcription regulator | Inhibited | -2.54e+00 | bias | 0.0e+00 | ACTA2,ARSG,BCL6,CDH1,CDKN1A,CDKN2C,CLCN3,DEPTOR,DUSP10,EGR1,EPHB4,ETS1,EYA1,FN1,FOXC1,FOXC2,HOXA5,HOXB5,HOXD4,IGFBP4,KLF6,KNL1,MYCT1,NEK1,PITX2,PRDM16,PROM1,RGS4,RSPO1,SCN1A,SIGLEC10,SNAI1,TGFB1,TRIB1,TWIST1 | 1559 (21) |
| NFATC2 | -4.40e-01 | transcription regulator | Inhibited | -2.54e+00 | NA | 0.0e+00 | ABCA1,ACP5,AXL,BATF,BCL2L1,BCL2L11,CASP3,Ccl2,CCNA2,CCR5,CD83,CD86,CDH2,CDKN1A,CISH,CITED2,COL2A1,CRYAB,CTNNAL1,CX3CL1,CX3CR1,CXCL10,CXCR5,DAB2,E2F5,EDN1,EGR2,EGR3,EZH2,FGL2,FOXP3,GBP4,GPNMB,IER3,IL17A,IL2RA,INHBA,IRF1,IRF4,ISG15,LAMP2,MAF,MAPK3,MITF,NFKBIA,NMI,NOX4,NR4A1,OASL,PLA2G2A,PLAT,PLD1,PLK2,PPARG,PTGS2,REL,RGS2,RILPL1,RSAD2,SELE,SLAMF1,SLCO3A1,SNAI1,SOCS1,SOCS3,STAT1,TGFB1,TLR2,TNFSF8 | 1272 (14) |
| HECTD2 | -1.02e+00 | enzyme | Inhibited | -2.54e+00 | NA | 0.0e+00 | B2M,Ccl2,CDK6,CXCL10,FN1,IL1RL1,ITGA5,PTGS2,SPP1,TNFAIP2 | NA |
| HOXD3 | -8.00e-02 | transcription regulator | Inhibited | -2.54e+00 | NA | 0.0e+00 | COL1A1,HOXD10,ITGA5,ITGB3,MMP2,SDC1,SERPINE1,TAGLN,TGFBI,THBS1 | NA |
| PRKACA | 2.00e-02 | kinase | Inhibited | -2.54e+00 | NA | 0.0e+00 | ADIPOQ,ANTXR1,ANTXR2,BCL2L11,BDNF,CCND1,CCND2,CREM,Giot1/Zfp347,HSPA1A/HSPA1B,ID2,IGF1,MYH10,OXTR,PENK,SDC1,SFRP4,SOCS3,VCAM1 | 1339 (21) |
| fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether | NA | chemical toxicant | Inhibited | -2.54e+00 | NA | 4.0e-02 | ATF3,Ccl2,CD44,CDO1,CXCL10,GPNMB,HSPA1A/HSPA1B,IL1RL1,SPP1,TIMP1 | NA |
| ethionine | NA | chemical toxicant | Inhibited | -2.55e+00 | NA | 0.0e+00 | ANXA1,CD44,CP,GCGR,GPNMB,IER3,LAMC2,PLA1A,S100A10,S100A11,SPP1,TES,TIMP1,TMSB10/TMSB4X,Tpm1,TSPAN8 | NA |
| TCF/LEF | NA | group | Inhibited | -2.55e+00 | bias | 0.0e+00 | CCND1,FN1,MITF,MMP2,PTGS2,RUNX2,S100A4,SERPINE1,SNAI2,VIM | NA |
| BMP10 | -6.10e-01 | growth factor | Inhibited | -2.55e+00 | NA | 0.0e+00 | A2M,ALDH1A3,ALOX12,APLN,BDH1,Ccl2,CCR1,CD74,CD83,CFI,COL12A1,COL1A1,COL3A1,CX3CR1,CXCL13,ECM1,EGR2,ENG,FAP,FCGR3A/FCGR3B,FGF2,FGL2,FN1,GLI1,GPR65,GRHL1,HLA-A,HTR2B,ICAM1,ID2,IGFBP7,ITGAL,KIT,LEPR,LTBP2,MMP14,MSR1,NCAM1,NFKBIA,NR4A1,NR4A2,NR4A3,PHLDA1,PTN,RPL22,RSAD2,SELE,SHMT1,SMAD6,SMAD7,SMAD9,THBS1,TIMP1,VCAM1,VCAN | 713 (7) |
| MMP3 | -7.60e-01 | peptidase | Inhibited | -2.55e+00 | NA | 1.0e+00 | BTBD1,CNOT6L,CPSF6,EGR1,ESRP2,MEX3B,NCBP2,PLCB1,PNPT1,PRPF40B,PSMA6,PTGES,PTGS2,SAFB,SRSF1,SRSF3,VIM | NA |
| RIPK1 | -3.20e-01 | kinase | Inhibited | -2.56e+00 | NA | 5.1e-01 | ARG1,ASNS,Ccl2,CXCL10,IL33,MAP3K14,MRC1,PDGFB,SLC1A1,SLC1A3,WNT5A | NA |
| Calcineurin A | NA | group | Inhibited | -2.56e+00 | NA | 0.0e+00 | ACTA1,ATP2A2,ATP2B4,CCND1,COL1A1,COL3A1,JAK3,MB,SCN5A,SLC2A1,TGFB1,TIMP1,TNNI1,UTRN | 1408 (21) |
| Creb | NA | group | Inhibited | -2.56e+00 | NA | 0.0e+00 | ACTA2,ADIPOQ,ALOX5,ANKRA2,ANTXR1,ANTXR2,APBA2,ARG1,ARHGEF9,ATF3,ATP13A5,ATP2A2,BCAS1,BDNF,C3AR1,CASP1,CCND1,CDKN1A,CEBPD,COL8A1,COX6A2,CREM,CSF1R,CSRP1,CXCL10,DDX6,DPY19L3,DUSP1,EGR1,EGR3,EPHA3,EPHB4,Esrra,ETV5,FCER1G,Fcrls,Foxp1,FSCN1,FXN,GDA,Gimap9,Giot1/Zfp347,GJA5,GNAS,GNB4,HAS2,IER3,IFI16,IGF1,IL33,INHA,IRS2,ITGA10,KCNA5,KCNC1,KDM2B,LASP1,Ldha/RGD1562690,MAT2A,MICB,MITF,MMP2,MPZ,NDFIP2,NDN,NEDD9,NMNAT2,NR4A1,NR4A2,NR4A3,NTS,OSBPL3,PCOLCE,PDE3B,PENK,PER1,PFKFB4,PGK1,PLAT,PLIN3,POLA1,PPARG,PRKAA2,PSENEN,PTGS2,RET,RGS2,SLC25A44,SLC2A1,Slco1a4,STAR,STMN1,TNFRSF11B,TSHR,UBC | 1380 (25) |
| ZFTA-RELA | NA | fusion gene/product | Inhibited | -2.56e+00 | bias | 0.0e+00 | BCL2L1,BCL3,BIRC3,Ccl2,CD44,CSF1,CX3CL1,CXCL10,FN1,ICAM1,IL15RA,IL1RN,IRF1,L1CAM,LITAF,NFKBIA,PDGFB,PRKCD,PTGS2,S100A6,SDC4,SMAD7 | NA |
| ALB | -8.60e-01 | transporter | Inhibited | -2.56e+00 | NA | 6.0e-02 | ACTA2,CASP3,Ccl2,CDKN1A,COL1A1,CX3CL1,CYBA,EDN1,EDNRB,FN1,HPSE,PTGS2,TGFB1 | NA |
| lipoteichoic acid | NA | chemical - endogenous non-mammalian | Inhibited | -2.57e+00 | NA | 0.0e+00 | ANTXR1,ANTXR2,BCL2L1,BCL2L11,Ccl2,CCR1,CCR5,CD83,CD86,CXCL10,CXCR4,CYBB,GLRB,HIF1A,ICAM1,IL17A,IL1RN,MMP2,NLRP3,NOD2,NR4A1,NR4A2,NR4A3,PTAFR,PTGS2,SELP,SLC16A3,TLR2,TLR4,TLR7,TNFRSF11B | 1027 (14) |
| PLA2G4A | -2.25e+00 | enzyme | Inhibited | -2.58e+00 | NA | 4.0e-02 | ANXA5,Ccl2,CX3CL1,ICAM1,PLA2G2A,PLA2G5,PTGS2 | NA |
| TLR2 | -1.90e+00 | transmembrane receptor | Inhibited | -2.58e+00 | NA | 0.0e+00 | ACTA2,ARG1,ATF3,BDNF,CASP3,Ccl2,CCR1,CCR5,CD86,CDKN1A,CEBPD,CISH,CRP,CSF2RA,CXCL10,CYBB,DUSP1,FBXO32,FN1,FOXO1,FOXP3,GADD45A,HLA-DQA1,HNRNPU,ICAM1,IL15RA,IL17A,IL1RN,IL2RA,IL33,IRAK3,IRF1,ITGA2B,ITGA4,ITGB7,MX1,MYH7,OLR1,OXTR,PTGFR,PTGS2,PTX3,SELE,SELP,SOCS1,SOCS3,TGFB1,TLR2,TLR4,TNFAIP8L2,TRIM63,TSPAN33,VWF | 1518 (15) |
| KITLG | -1.38e+00 | growth factor | Inhibited | -2.58e+00 | NA | 0.0e+00 | AIF1,ALOX5,AXL,B2M,BCL2L1,BCL2L11,BLVRB,BMP1,BTG1,CASP1,CASP3,Ccl2,CCNA2,CDC42EP5,CDKN1A,CISH,CLIC1,CMA1,CSF1,CSF3R,CX3CL1,CXCL12,CXCR4,CYTH1,DALRD3,DCTN6,EDNRB,EEF1A1,EGR1,EPHB4,F2R,FGFR1,FRK,GFAP,GRIA2,HCK,ID2,IL16,IL1RL1,IL1RN,ITGA2B,ITGAE,ITGB3,KDR,KIT,MME,MMP2,MS4A2,N4BP2L1,NFKBIA,NMNAT1,PDGFB,PKM,Podxl,PRKCB,PRKCE,PRKCQ,PSMB5,PTGER3,PTGS2,RNF128,SAMSN1,SLC20A2,SNAI2,SOCS1,SYK,TAF1C,TAL1,TNNI1,TPH1,TXNL1,UGCG,USF2,VWF,WEE1 | 1272 (20) |
| MAP2K1/2 | NA | group | Inhibited | -2.59e+00 | NA | 0.0e+00 | ATF3,BCL2L11,BDNF,C3,Ccl2,CCND1,CCND2,CDH1,CHI3L1,DUSP1,EGR1,EGR2,ELN,FOXP3,GCLC,HERPUD1,IL2RA,JAG1,KLF5,MYH2,NOX1,PHLDA1,PIK3CG,PRKCI,VIM | 1135 (17) |
| cholecalciferol | NA | chemical - endogenous mammalian | Inhibited | -2.59e+00 | NA | 0.0e+00 | ALOX5,ANXA2,BCL2L1,BDNF,BRAP,CALCR,CD83,CD86,CDH1,CEBPD,COL1A1,CSF1,CTSK,CXCL10,CYP27A1,EDN1,F13A1,FAM20C,FOXP3,GAS7,IGF1,ITGB2,KIT,LRRC25,LY75,MS4A6A,MYH2,MYH6,MYH7,NFYA,NR0B2,PDGFRA,PDK4,PPARG,PPARGC1B,PRKCB,PRKX,PTPRB,PVALB,RARA,RUNX2,SERPINB8,SERPINE1,SLC20A1,SPP1,SULF2,TGFB1,TNFRSF11B,TNNC1,TNNT1,UBE2E1 | 1356 (20) |
| SPHK1 | 1.30e+00 | kinase | Inhibited | -2.59e+00 | NA | 0.0e+00 | ACTA2,BCL2L1,BCL2L11,BIRC3,Ccl2,CCND1,CDKN1A,EGR1,FN1,GCH1,HIF1A,ICAM1,IL17A,IL33,OAS3,PTGES,PTGS2,SELP,SERPINE1,SLC2A1,SOCS3,SPHK1,TAGLN,TIMP1 | 1309 (16) |
| Laminin5 | NA | complex | Inhibited | -2.60e+00 | NA | 0.0e+00 | CAMK2A,FN1,MMP14,PLOD2,S100A10,SPARC,SPP1 | 1168 (23) |
| leukotriene B4 | NA | chemical - endogenous mammalian | Inhibited | -2.60e+00 | NA | 1.5e-01 | Ccl2,ENPP3,F3,IRF5,LTB4R,NOX4,SOCS1 | NA |
| IL18 | -3.80e-01 | cytokine | Inhibited | -2.60e+00 | NA | 0.0e+00 | ACTA1,ADAM19,ADAMTS5,ADIPOQ,ARG1,ATF3,BCL2L1,BCL6,Ccl2,CCR5,CCRL2,CD226,CD244,CD44,CD83,CD86,CDH1,CSF1,CX3CR1,CXCL10,CXCL12,CXCL16,DDIT4,EDNRB,FCGR3A/FCGR3B,GADD45B,GADD45G,GIMAP4,GZMB,HLX,ICAM1,IL17A,IL18BP,IL18R1,IL2RA,INPP5D,IRF1,ITGAL,KIT,MMP15,NFIL3,PENK,PTGS2,SPP1,TIMP1,TLR4,TNFRSF11B,TNFRSF25,VCAM1 | 1177 (14) |
| DOCK8 | -9.00e-01 | other | Inhibited | -2.60e+00 | bias | 0.0e+00 | ARID5A,CCND2,CITED2,CXCL10,DAB2,EDN1,FGL2,HDC,IL15RA,INHBA,IRF1,ISG15,NMI,PLA1A,PLAT,PTGS2,RBL1,REL,RILPL1,RSAD2,SAP30,SLCO3A1,SOCS1,STAT1,TNFSF8 | NA |
| MDK | -7.20e-01 | growth factor | Inhibited | -2.60e+00 | NA | 0.0e+00 | ACTA2,Cald1,Ccl2,CSF1,CXCL16,GZMB,LGALS1,MYOCD,PLAT,PTN,PTPRC,S100A6,SPP1,TAGLN,TGFB1,WNT5A | 1258 (18) |
| cicaprost | NA | chemical drug | Inhibited | -2.60e+00 | NA | 0.0e+00 | ADAMTS1,ADAMTS5,CCNA2,CSF2RB,CXCR4,FGF2,HAS2,HIF1A,IL1R1,IL1RL1,PLA2G4A,SDC1,THBD,UAP1,VCAN | 916 (13) |
| vemurafenib | NA | chemical drug | Inhibited | -2.61e+00 | NA | 3.0e-01 | B3GNT2,DDR2,DUSP6,GPNMB,GZMB,ID2,MITF | NA |
| TRAP1 | 6.00e-02 | enzyme | Inhibited | -2.61e+00 | NA | 0.0e+00 | ALDH1L2,ANXA1,CD44,CNNM4,ECSIT,GAPDH,GFER,GNG2,GPT2,HIF1A,HSPE1,ISCU,L1CAM,LSS,MAVS,MRPL18,MTHFD2,NCAM1,PECR,PKM,PPP2R2B,PTGS2,RAB38,SLC2A1,SLC35D1,SRSF1,STARD8,SYK,TIMM13,TRADD,TWIST2 | 712 (7) |
| LAMA5 | -5.00e-02 | other | Inhibited | -2.61e+00 | bias | 1.0e-02 | Ccl2,Ccl7,CCR1,CXCL10,MMP14,STAT1,TNFRSF1B | NA |
| TGFB3 | -2.00e-01 | growth factor | Inhibited | -2.62e+00 | NA | 0.0e+00 | ACTA1,ACTA2,ACTG2,ADAM19,BHLHE40,CDH1,CDH2,CDH6,CDKN1A,COL11A1,COL1A1,COL2A1,COL3A1,COL5A1,EEF1D,ELN,ENG,ETS1,F2RL1,FGF2,FN1,ITGB3,JUND,LEF1,LTBP2,MICAL2,MMP2,MYO10,OCLN,PALLD,PLK1,PLOD2,PTAFR,RHOA,SERPINE1,SMAD7,SNAI1,SNAI2,STAT6,TAGLN,TGFB1,THBS1,TNC,TNFRSF11B,TSPAN2,ZEB2 | 1427 (19) |
| SPZ1 | NA | transcription regulator | Inhibited | -2.62e+00 | NA | 0.0e+00 | CCND1,CD44,CDH1,CDH2,FN1,HIF1A,MAPK3,MKI67,PROM1,SNAI1,SNAI2,TWIST1,VIM,WNT5A | 832 (6) |
| NFKB1 | -1.10e-01 | transcription regulator | Inhibited | -2.62e+00 | NA | 0.0e+00 | A2M,AHRR,ANKRD1,ANKRD2,ARG1,ATP6AP2,B2M,BAMBI,BCL2A1,BCL2L1,BCL3,BHLHE40,BIRC3,BRCA2,BTG2,Ccl2,CCND1,CCND2,CD44,CD83,CD86,CDKN1A,CFB,CHI3L1,CIITA,COL1A1,COL2A1,CRP,CSF1,CSF2RA,CX3CL1,CXCL10,CXCR5,CYBB,DTX1,DUSP1,E2F7,EGR1,FCGRT,FN1,FOXP3,FSCN1,GADD45A,GFRA1,GNAI3,GRK5,HAS2,HOOK2,ICAM1,IER3,IFI16,IKBKB,IKBKE,IL10RA,IL1RN,IL2RA,IRF1,IRF4,ISG15,JAG1,KCNT2,LGALS1,MAT2A,MMP2,MSR1,NFKBIA,NFKBIB,NMI,NOD2,NR4A1,NR4A2,NR4A3,PLK3,POU2F2,PRKCD,PTAFR,PTGS2,PTPN6,PTX3,RAB31,RIPK3,RPS6KB1,SDC4,SELE,SELP,SNAI2,STAT1,TGFB1,TLR2,TNFRSF4,TP63,VCAM1,VEGFC | 1360 (11) |
| Betacatenin/TCF | NA | complex | Inhibited | -2.62e+00 | bias | 1.0e-02 | CCND1,CD44,FGF9,LEF1,NR5A2,RUNX2,TNFRSF11B | NA |
| RIPK3 | -9.60e-01 | kinase | Inhibited | -2.62e+00 | NA | 4.0e-02 | ACTA2,Ccl2,MLKL,NLRP3,PYCARD,ROCK1,TGFB1,TLR4 | NA |
| 2-acetylaminofluorene | NA | chemical toxicant | Inhibited | -2.62e+00 | NA | 1.0e-02 | ABCC3,CCND1,CDKN1A,DLK1,DLL1,JAG1,NOTCH2 | 1282 (16) |
| TBX21 | -8.40e-01 | transcription regulator | Inhibited | -2.62e+00 | NA | 8.0e-02 | CCR5,CD244,CDK6,CX3CR1,CXCL10,CXCR5,FAM89B,GZMB,HLX,IL17A,IL1RL1,IL2RB,ITGAE,PRDM1,RUNX1,SPP1,Tcf7,ZEB2 | NA |
| NTRK2 | -7.40e-01 | kinase | Inhibited | -2.63e+00 | NA | 0.0e+00 | BCL2L11,BDNF,CASP1,CCNA2,CCND1,CCND2,CCNE2,CDH1,CDKN1A,CDKN2C,DAPK1,EGR1,FGF2,GAD1,HEY2,HGF,JAG1,KCNJ9,MYCN,PIK3R1,PVALB,PYCARD,RUNX2,SERPINE1,SPP1,SYP,THBS1,TP53BP2,TWIST1,VIM | 1409 (19) |
| EDNRA | -3.80e-01 | transmembrane receptor | Inhibited | -2.63e+00 | bias | 1.0e-02 | COL1A1,COL3A1,ICAM1,MMP2,PTGS2,TGFB1,TIMP1 | 1335 (20) |
| EWSR1 | NA | other | Inhibited | -2.63e+00 | NA | 4.2e-01 | ACKR3,BHLHE22,CCND1,F2RL1,KIT,PCDH17,TOP2A | NA |
| leukotriene C4 | NA | chemical - endogenous mammalian | Inhibited | -2.63e+00 | bias | 1.0e-02 | EGR1,EGR2,EGR3,ICAM1,PTGS2,SELP,VCAM1 | NA |
| RETN | -1.45e+00 | other | Inhibited | -2.63e+00 | NA | 0.0e+00 | ADIPOQ,Ccl2,CX3CL1,CX3CR1,EDN1,ICAM1,LPL,mir-143,MKI67,MMP14,PLAT,PTGS2,RETN,SELE,SELP,SERPINE1,SOCS3,SPP1,SREBF1,TLR4,VCAM1 | 1330 (19) |
| semaxinib | NA | chemical drug | Inhibited | -2.63e+00 | NA | 0.0e+00 | ACKR3,ACP5,AHR,AHRR,AIF1,ALDOA,ARG1,ARHGEF10,ATF3,CARD11,CASP3,Ccl2,CCL21,CCR1,CCR5,CD28,CHI3L1,CMKLR1,CSF2RB,CX3CR1,CXCL10,CXCL13,CYP1B1,EDN1,EGR1,EGR2,F3,FHL1,FOXO1,GDF11,GREM1,HIF1A,IL1R1,IL2RB,IL34,IRF4,KDR,LMOD1,LRG1,MYOCD,MYOF,NADK,NFE2L2,NFKBIA,NLRP3,NOX1,NR4A2,OAS3,PPIA,PRKCQ,PTGIS,PTGS2,PTX3,RASGRP1,SELE,SEMA6B,SERPINE1,SOCS3,TGFB1,THBS1,TLR5,VWF | 1528 (21) |
| uric acid | NA | chemical - endogenous mammalian | Inhibited | -2.63e+00 | NA | 1.1e-01 | ADIPOQ,ANO6,ANXA1,CASP1,Ccl2,CD86,CDK2,CRP,CYBB,ESPL1,ICAM1,IL17A,ISG15,ITGB3,KHK,KIF1A,MAFA,NFAT5,NLRP3,PRKDC,PTGS2,RSAD2,TACC2,TGFB1,TYMS,USP18,VCAM1 | NA |
| TEAD3 | 2.80e-01 | transcription regulator | Inhibited | -2.64e+00 | NA | 0.0e+00 | ACTA1,ACTA2,AK5,ARID5B,COL3A1,COL5A2,EDN1,FIBIN,IGFBP5,KAZN,LIMCH1,LOXL1,MYH7,NRXN2,NUAK1,PCDH18,PDGFRL,PTPRO,RHOBTB1,SAMD5,SDC2,SH3D19,TAGLN,THBS1,TLE1,TNNC1,TNNT2,TP63 | NA |
| CD44 | -1.59e+00 | other | Inhibited | -2.64e+00 | NA | 0.0e+00 | ACKR3,ACTA1,ACTA2,ADGRE1,ADRB2,ALDH1A1,ALDOA,BCL2L1,BGN,BIRC3,Ccl2,Ccl7,CCND1,CCND2,CCR5,CD36,CD44,CDH1,CDKN1A,COL18A1,COL1A1,COL3A1,COL5A2,CTSK,CX3CL1,CX3CR1,CXADR,ECM1,ENO2,F3,FKBP5,FN1,GADD45A,HAS3,HK1,IL1RN,IL2RA,IRAK3,ITGA3,ITGA4,ITGA5,ITGBL1,KLF4,LGALS1,LIMS2,LTBP1,LTBP2,MET,MMP14,MMP2,NOX4,PDK4,PFKFB3,PFKFB4,PGK1,PGM2L1,PKM,PLPP3,PMEPA1,PPARG,PTP4A3,SDC4,SFRP2,SLC2A1,SPP1,STEAP1,THBS1,THBS2,THY1,TLR8,TWIST1,VCAM1,VCP,VIM,WNT2,WNT5A | 1604 (17) |
| C5 | NA | cytokine | Inhibited | -2.64e+00 | NA | 0.0e+00 | ACTA2,ATF3,BCL6,BCL6B,C3AR1,C5AR1,Ccl2,CCND1,CD86,CDH11,CRP,CSF1,CXCL10,CYBB,EGR1,EIF2AK3,F3,FCGR1A,FCGR2B,FN1,HGF,ICAM1,IL17A,IL18R1,ITGB2,MET,NFE2L2,NFKBIA,PLAT,PLK3,SELE,SERPINE1,SLC25A15,SMAD7,ST6GAL1,TGFB1,TNFAIP2,VCAM1,VEGFC,ZFP36 | 1082 (13) |
| ATP6AP2 | -5.90e-01 | transporter | Inhibited | -2.64e+00 | bias | 0.0e+00 | ACTA2,ATP6AP2,CYBB,FN1,NOX4,PTGS2,TGFB1 | 967 (9) |
| ELOVL3 | 2.70e-01 | enzyme | Inhibited | -2.65e+00 | NA | 0.0e+00 | Actn3,C3AR1,CD53,COL3A1,COL6A3,CTSS,CYBB,ELOVL7,FCER1G,GPNMB,HACD3,HLA-DRA,IFI16,IQGAP2,ITGB2,LSS,LUM,MICOS10,MMP2,MSMO1,MSR1,MVD,MVK,PLA2G4E,PLA2G7,PVALB,SPP1,TIMP1 | NA |
| COL17A1 | NA | other | Inhibited | -2.65e+00 | NA | 0.0e+00 | AXIN2,FZD4,NFATC4,WNT2,WNT2B,WNT4,WNT5A | 1085 (7) |
| CLEC1B | 1.00e-01 | transmembrane receptor | Inhibited | -2.65e+00 | bias | 0.0e+00 | CXCL12,IL7,LCP2,PLCG2,SPP1,SYK,TNC | 369 (7) |
| Col17a1 | -6.90e-01 | other | Inhibited | -2.65e+00 | NA | 0.0e+00 | AXIN2,FZD4,NFATC4,WNT2,WNT2B,WNT4,WNT5A | 1085 (7) |
| SUCNR1 | -5.90e-01 | G-protein coupled receptor | Inhibited | -2.65e+00 | NA | 4.0e-02 | ACTA2,COL1A1,COL3A1,COL5A1,COL5A2,LAMA2,NID1 | NA |
| formaldehyde | NA | chemical - endogenous mammalian | Inhibited | -2.65e+00 | NA | 4.0e-01 | EGR1,EGR2,GFAP,JUND,PENK,PFKFB3,PTGS2,SGK1 | NA |
| etoposide | NA | chemical drug | Inhibited | -2.65e+00 | NA | 0.0e+00 | ABCG1,ADAM10,ADAM17,ATF3,BANK1,BCL2A1,BCL2L1,BCL2L11,BCL6,BDNF,BIN1,BIRC3,C1R,CASP1,CASP3,CCND1,CCRL2,CD86,CDC25B,CDKN1A,CROCC,CSF2RB,CSNK1D,CXCL10,DDIT4,DUSP1,EEF1A1,EPSTI1,FANCA,FOXP3,GADD45A,GADD45G,GBP2,GZMB,HIF1A,HK1,HLA-DQA1,ICAM1,ID2,IER3,IFI44L,IL10RA,IL17A,IL2RB,IL7,IRF1,IRF8,KCNK1,LIMA1,LPAR6,MME,NR4A1,PEBP1,PIK3R3,Pmaip1,PTGS2,REL,SERPING1,SGK1,SLC2A1,SMAD9,SPHK1,STAT1,TNFRSF10A,TOP2A,TP63,TRADD,UBA7,UBE2L6,UHRF1,ZNF281 | 1406 (18) |
| indomethacin | NA | chemical drug | Inhibited | -2.66e+00 | NA | 0.0e+00 | A2M,A3GALT2,ACSL1,ADAMTS1,ADAMTS5,ALOX15,ALOX5,ANGPT2,ANXA1,ANXA2,ASNS,ATP6V0B,BCL2L1,BDNF,Bex2/LOC100912195,BIRC3,BTG2,Ccl2,CCND1,CD34,CD44,CD86,CDH1,CDKN1A,CLDN1,CP,CSF2RB,CXCR4,DYNLL1,EMP3,FBLIM1,FGF2,GCGR,GPNMB,HAS2,HGF,HIF1A,ICAM1,IER3,IFITM3,IGF1,IL17A,IL1R1,IL1RL1,ITGB4,LAMC2,LIMA1,LOXL2,LPL,MMP14,MMP2,MRC1,NOS1,OCLN,PLA1A,PLA2G4A,PPARD,PPARG,PROM1,PSMB5,PTGES,PTGS2,RXRA,S100A10,S100A11,SDC1,SPP1,STAR,STAT6,TEK,TES,TFPI2,TIMP1,TMSB10/TMSB4X,TSPAN8,TUBB,UAP1,UQCR10,VCAN,VIM | 1413 (15) |
| cholic acid | NA | chemical - endogenous mammalian | Inhibited | -2.66e+00 | NA | 1.0e-02 | ABCA1,ABCC3,ABCC4,CYP27A1,CYP7B1,DHCR7,EGF,EPHX1,FABP1,IGFBP5,KCNJ13,LCAT,LPL,MDK,MGST1,NR0B2,PLTP,Slco1a4,SREBF1,TAGLN,VIPR2 | NA |
| TNFRSF1B | -9.10e-01 | transmembrane receptor | Inhibited | -2.66e+00 | NA | 6.0e-02 | ABCC3,ANGPT2,BCL2L1,CASP3,CCR5,CXCL12,CXCL13,FOXP3,GAP43,GFAP,ICAM1,IL2RA,LBP,MMP14,MMP2,MSR1,MYOD1,NR5A2,NTN1,Podxl,PRDM1,SERPINE1,SOCS3,TGFA,TIMP1 | NA |
| CCR5 | -1.90e+00 | G-protein coupled receptor | Inhibited | -2.67e+00 | NA | 1.3e-01 | CASP3,CASP8,Ccl2,CCR5,CD9,CXCL10,CXCL12,F3,IL17A,TNFRSF1B | NA |
| JAK2 | -2.20e-01 | kinase | Inhibited | -2.68e+00 | NA | 0.0e+00 | ACER2,AKAP12,ALOX5,BCL2L1,BCL2L11,CASP1,Ccl2,CCND1,CCND2,CD36,CDH1,CDKN1A,CEP112,CST7,CXCL10,CYBB,EGR1,F5,FCGR2B,FGF2,FN1,FOXO1,GBP2,GCNT2,GFAP,HTR2A,ICAM1,IL17A,IRF1,ITGA5,LAT2,LMO2,LYN,Milr1,NDN,NR4A1,OSMR,PCBP4,PFN1,PLK2,PRKCB,PTGS2,RARA,SDC4,SELP,SEMA6B,SERPINH1,SLAMF9,SLC1A3,SOCS1,SOCS3,SPTB,STAT1,THBS1,TRAM1 | 1047 (16) |
| ETV4 | -5.30e-01 | transcription regulator | Inhibited | -2.68e+00 | NA | 0.0e+00 | ACTA2,ARID3B,B4GALT1,CAV1,CDH1,CXCR4,FN1,HPSE,MET,MMP14,PTGS2,SPP1,TWIST1,VIM | 852 (7) |
| ARID3A | -2.70e-01 | transcription regulator | Inhibited | -2.68e+00 | bias | 1.0e-02 | CCNA2,CXADR,CYP2S1,DEK,ECT2,FGF2,FOXO1,FZD5,HOMER1,HPS3,KDM3A,KIF5C,LRRN1,LYPLA1,MAN2A1,NCAPG2,POLR3G,PROM1,SLC38A1,SLC39A10,TMEFF1 | NA |
| SOX11 | -8.00e-01 | transcription regulator | Inhibited | -2.69e+00 | NA | 1.0e-02 | ADAM10,ADAMTS5,BMP4,CAV1,CCDC186,CCND1,CD86,CD9,CNOT6,CP,CSF2RA,CXCR4,DBN1,DMBT1,EBF1,EGR1,FCMR,IFIH1,IL1RL1,ITGA4,LEF1,LGALS9B,MPZ,MSI2,MYF5,MYOD1,NTN1,PPP3CA,PRDM1,RUNX2,SKAP2,STAT1,TFDP2,TUBA1A,WNT4 | NA |
| SAA | NA | group | Inhibited | -2.70e+00 | NA | 0.0e+00 | ARG1,BCL2L11,Ccl2,CSF1,F3,ICAM1,IL17A,IL1RN,IL33,IRF4,MRC1,NLRP3,PLA2G2A,PLIN1,PTGS2,TLR2,VCAM1 | 1065 (14) |
| IPMK | 2.00e-02 | kinase | Inhibited | -2.71e+00 | NA | 0.0e+00 | ACTA2,AHR,BATF,CORO1A,CSRP1,FGL2,FLNA,IL1RL1,IRF4,ITGA3,ITGAE,ITGB3,MAF,PER1,PFN1,PMP22,PRDM1,RHOA,TAGLN2,Tcf7 | 1032 (17) |
| MEIS2 | 2.00e-02 | transcription regulator | Inhibited | -2.71e+00 | bias | 0.0e+00 | CDH1,ETV1,IGF1,OSR1,OSR2,PAX3,PTCH1,RUNX2,SHOX2,TWIST1,WNT5A | 37 (3) |
| NfkB1-RelA | NA | complex | Inhibited | -2.72e+00 | NA | 1.8e-01 | CCND1,DUOX2,ICAM1,IRF8,MMP2,NOD2,PTGS2,RIPK2,SELE,TNFRSF11B,VCAM1 | NA |
| TLN1 | -5.00e-02 | other | Inhibited | -2.72e+00 | bias | 0.0e+00 | AMIGO2,Ccl2,CXCL10,GBP2,Ggta1,HLA-A,ICAM1,IL2RA,ITGA1,ITGA5,ITGAL | 1077 (15) |
| PLAU | -1.00e-02 | peptidase | Inhibited | -2.74e+00 | NA | 0.0e+00 | ABCG1,ACTA2,ARG1,BCL2L1,C5AR1,Ccl2,CCND1,CCR5,CDH2,F3,FCGR1A,FN1,HGF,ICAM1,IGF1,KDR,OAS3,PHLDA1,PIK3CG,PIM3,PLK3,PTN,SERPINE1,SLC2A1,SLFN13,SNAI1,VIM | 1394 (20) |
| EBI3 | 4.80e-01 | cytokine | Inhibited | -2.74e+00 | NA | 0.0e+00 | B2M,CCL24,CCND2,CD86,CIITA,CTSE,ENTPD1,GADD45G,GBP2,HLA-A,HLA-DOB,HLA-DQA1,HLA-DRA,ICAM1,IL17A,IRF1,MX1,STAT1 | 1136 (16) |
| CYLD-AS1 | NA | other | Inhibited | -2.75e+00 | NA | 0.0e+00 | ABCC3,BLVRB,C3,CFB,CSF1,CYP1B1,EPHX1,FTL,G6PD,GCLC,GLRX,ICAM1,IRF1,MGST1,NFE2L2,NFKBIA,PPARG,PPARGC1B,PRDX1,RXRA,TKT,TNFAIP2,TNFAIP6,TNFAIP8,TNFAIP8L3,UGDH,VEGFC | NA |
| deoxycorticosterone acetate | NA | chemical drug | Inhibited | -2.75e+00 | NA | 0.0e+00 | ATP6AP2,Cald1,COL1A1,COL3A1,CYBA,EDN1,PTGS2,SELE,SELP,SLC9A1,SPP1,TGFB1,TNC,VCAM1 | 1026 (9) |
| F2RL1 | -2.04e+00 | G-protein coupled receptor | Inhibited | -2.75e+00 | NA | 2.0e-02 | ACTA2,ATF3,BCL3,BDNF,CAV1,DUSP6,F2RL1,F3,GBP2,GBP4,IRF8,ITGB4,KITLG,LOXL4,LRAT,NTS,OSMR,PKIB,PTGS2,RAB27A,RARG,STK32A,TGFA,TIFA,VEGFC | NA |
| resiquimod | NA | chemical drug | Inhibited | -2.75e+00 | NA | 0.0e+00 | ACADS,ACTG1,AIF1,ATF3,BATF,BCL2A1,BCL6,C3,C3AR1,CASP8,Ccl2,CCL24,Ccl7,CCND2,CCR1,CCRL2,CD180,CD22,CD226,CD44,CD83,CD86,CIITA,CREB5,CSF1R,CSK,CXCL10,CXCL12,CXCL13,DHX58,DLL1,DOCK10,EZR,F2R,FCER1G,FCGR1A,FCGR2B,FEZ1,FGF2,GM2A,GNG2,GPNMB,GPR160,GPR183,GRAP,GRHPR,HCK,HDAC9,HERPUD1,HHEX,HSP90AA1,ICAM1,IER3,IFI16,IFI44L,IFIT1,IFITM3,IGFBP4,IL16,IL17A,IL2RA,IL33,IL7,INHBA,IRAK2,IRAK3,IRF4,IRS2,ISG15,JAK3,KHDRBS1,LAT2,LGALS1,LYN,LYST,MSN,MX1,MYO1G,NCKAP1L,NFAM1,NFE2L2,NFKBIA,NLRP3,NOD2,NOTCH2,OAS3,OASL,PARK7,PDE4D,PIK3CG,PKM,PLAT,POU2F2,PRDM1,PRDX1,PRKCB,PRKCE,PRKDC,PSMA4,PSMA6,PSMB1,PSMB5,PSMC1,PSMC5,PSMD13,PTGIR,PTGS2,PTPN6,PTPRC,PTX3,PYCARD,RAB7A,REL,RGCC,RIPK2,RUNX1,SEMA7A,SOCS3,SPP1,STAT1,STMN1,STOML2,THEMIS2,TICAM2,TLR10,TLR2,TLR4,TLR7,TLR8,TNFRSF8,TRPM2,VOPP1,ZFP36L1,ZFP36L2 | 1223 (17) |
| IL10RA | -1.01e+00 | transmembrane receptor | Inhibited | -2.76e+00 | NA | 0.0e+00 | ABCG1,ACSL1,ACSM3,ADD3,ADH1C,ALOX5,ANO1,B3GNT7,BMP4,BOC,C3,CD1D,CD300LF,CD34,CD36,CERS4,Ces2g,CFB,CLCN7,CLEC12A,CLEC4M,CLIC6,COL14A1,CSF3R,CSRP2,CST7,CTSE,CYP2S1,DCN,DDHD1,DDIT4,DRAM1,ECM1,EDN1,EDNRB,EGF,EMP2,ETV1,F13A1,FADS3,FBN1,Fcrls,FHL1,FN1,FOLR2,FOXP3,FSTL1,GBP2,GBP5,GDA,GPR171,GSAP,Gsta4,H2-T22,HCAR2,HGF,HLA-A,HMCN1,HPSE,HTR7,IFI16,Ifi47,IKBKE,IL15RA,IL17A,IL18BP,IL1RN,IL2RG,INHBA,IRF1,ITGB7,KITLG,LGALS12,LRG1,LUM,MAOB,MLKL,MSRB1,NPL,NR5A2,OCLN,OGN,OLR1,P3H2,PAM,PCOLCE,PDGFRA,PMP22,PYGL,RGS18,RIPK3,RNF213,RSAD2,SELENBP1,SERPINB9,SLC16A3,SLC2A1,SLCO2B1,SOCS3,SORBS2,SPARC,SPON1,ST3GAL6,STARD8,STAT1,TGFB1,THBS4,Tlr11,TLR2,TRPM2,ZC3H12C | 962 (16) |
| E. coli lipopolysaccharide | NA | chemical - endogenous non-mammalian | Inhibited | -2.76e+00 | NA | 1.1e-01 | BCL2L1,BCL2L11,Ccl2,CD83,CD86,CEBPD,CXCL10,FOXP3,ICAM1,MVD,MX1,PTGS2,SELE,SOCS3,TGFB1,TLR4,VCAM1 | NA |
| CD3 | NA | complex | Inhibited | -2.77e+00 | NA | 0.0e+00 | ACADS,ACTG2,ACTN4,AHR,ANXA1,AP1B1,APBA1,ARHGDIB,BAMBI,BATF,BCL2A1,BCL2L1,BCL2L11,BCL6,BIRC3,BTG1,C1R,C2,CAMK2A,CASP3,CASP8,CCND1,CCND2,CCR1,CCR5,CD226,CD28,CD44,CD53,CD74,CD83,CD86,CDK2,CDK6,CEACAM1,CENPF,CISH,CLK1,CORO1A,CRB1,CREM,CXCL10,CXCR4,CYBA,DAD1,DOCK2,DPP4,DUSP11,EBP,EDIL3,EEF1A2,EGR2,EGR3,ELK3,ETS1,FCER1G,FOXP3,FTL,FUT7,FYN,G6PD,GAPDH,GGT5,GLI1,GNAS,GZMB,H2AC18/H2AC19,HAX1,HCCS,HIF1A,HINT1,HIVEP3,HMCN1,HMGN1,HNRNPR,HOMER2,HSP90AA1,HSPA1A/HSPA1B,HSPE1,ICAM1,ID4,IFIT1,IFRD2,IGF1,IGFBP5,IGFBP6,IL10RB,IL15RA,IL16,IL17A,IL18R1,IL1R1,IL2RA,IL2RB,IL2RG,IL4I1,IRF1,IRF4,IRF8,ITGA4,ITGB7,JAK3,KCNA5,KCNK3,KDELR2,LCP1,LEF1,LTBP1,LYN,LYPLA1,MAF,MAP3K10,MMP2,MMRN1,MSLN,MSR1,MTHFD2,NDFIP2,NFAT5,NFE2L2,NFKBIA,NLGN3,NOS1,NR4A1,OAZ1,OGN,PDE4A,PDE4D,PDIA4,PFN1,PLEK,POLR2F,POLR2K,PPARG,PRDX4,PSMA6,PSMC1,PTGS2,PTP4A2,PTPN7,PTPRC,PTPRJ,PYGL,RAB2A,RAB8A,RAC2,REL,RNF128,RPL6,RXRA,S100A11,SLC7A1,SMO,SMPDL3B,SNRPN,SOCS1,SOCS3,SRP14,SRSF1,STAT1,STEAP2,STMN1,TFDP2,TFPI2,TGFB1,THBS1,THY1,TLR2,TNFRSF25,TNFRSF4,TNFRSF8,TNFSF18,TOB2,TOP2A,TPST1,TRA2A,TRAF5,UBE2L6,UQCR11,VIPR2,WEE1,ZFP36,ZFP36L1 | 1289 (18) |
| Insulin | NA | group | Inhibited | -2.77e+00 | NA | 0.0e+00 | ABCA1,ABCC8,ACSL1,ACTA1,ACTC1,ADAM10,ADH1C,ADIPOQ,ALDOA,APLN,APLNR,AQP7,ARF1,ARRDC3,ASGR2,ATF3,ATP1A1,BCKDHA,BCL2L1,BDH1,BDNF,BPGM,CA14,CA3,CACNA1B,CASP1,CAV2,Ccl2,CCND1,CCNE2,CD34,CD36,CD44,CDK2,CDKN1A,CEBPD,CKM,CNN1,COL18A1,COL1A1,COL3A1,COL5A1,COX4I1,COX6A2,Cox8b,CREB1,CRYAB,CYBB,CYP27A1,DDIT4,DLK1,DNAJB4,DUSP1,DYNLL1,EDN1,EGR1,EGR2,EIF4EBP1,ERCC1,ERRFI1,FADS1,FADS2,FBN1,FBP2,FBXO32,FGF2,FN1,FOXC2,FOXO1,FOXO3,FTL,G6PD,GAPDH,GCLC,GFAP,GFPT2,GPD1,GSK3A,HAP1,HIF1A,HIF3A,HPSE,HSD17B4,HSP90AA1,HSPE1,ICAM1,IDH1,IGF1,IGFALS,IGFBP4,IGFBP5,INHBA,IRS1,IRS2,ITGA1,ITGA3,ITGA6,ITGB3,KCNJ11,KLF4,LDHB,LEPR,LGALS12,LPIN1,LPL,MAOB,MAPK3,MCM7,mir-133,MMP2,MPZ,Mt1,MYOD1,MYOG,NCF1,NDUFA1,NDUFB9,NDUFV1,NFIL3,NFKBIA,NLRP3,NOS1,NPR1,NR4A1,NR4A2,NR4A3,OCLN,OGT,OSTN,PDGFRA,PDK2,PDK4,PER1,PFKFB3,PGK1,PIK3R1,PKM,PLAT,PLCB1,PLIN1,PLIN3,PNPLA2,PPARD,PPARG,PPARGC1B,PPIA,PPIB,PPIC,PRKAA2,PRKCB,PRKCD,PRKCQ,PRKCZ,PTGFRN,PTGS2,PYCARD,RBL1,RDH5,RETN,RGN,RHOA,RPS16,RPS6KB1,RSPO1,RSPO3,RUNX2,RXRA,Scd2,SELENOP,SERPINE1,SERPINF1,SFTPB,SGK1,SKP2,SLC27A1,SLC2A1,SLC2A5,SLC37A4,SLC38A2,SLC38A3,SLC3A1,SLC7A1,SMAD7,SNAI1,SOCS3,SORT1,SPARC,SREBF1,SRSF3,STAR,STAT1,STX4,SYP,SYT3,TGFA,TGFB1,TGFBI,THBS1,THBS2,THY1,TIMP1,TLR2,TNC,TPO,TRIM63,TRPV1,TSHR,TTF2,UGT8,UMPS,VAMP5,VIM,VTI1A,WNT4 | 1708 (20) |
| colchicine | NA | chemical drug | Inhibited | -2.77e+00 | NA | 1.0e+00 | ACTA2,ATF3,BDNF,GAP43,HIF1A,JUND,MX1,PTGS2,TMEM123 | NA |
| ITGA9 | -8.20e-01 | other | Inhibited | -2.78e+00 | NA | 0.0e+00 | ACTA2,Ccl2,CDH1,CDH11,CDH2,CXCL12,CXCL14,MMP14,SNAI1,TGFB1,TNC,VIM | 1406 (23) |
| tamibarotene | NA | chemical drug | Inhibited | -2.78e+00 | NA | 0.0e+00 | APLN,CEACAM1,F3,GAP43,IL17A,ISLR,ITGB2,LEPR,RARA,RARG,SLC16A2,THBD | 1070 (18) |
| MAPK11 | -3.50e-01 | kinase | Inhibited | -2.78e+00 | NA | 1.3e-01 | ACP5,CAV1,mir-133,MYH6,NPR1,PRDX1,PTGS2,TIMP1 | NA |
| CNTF | -2.20e-01 | cytokine | Inhibited | -2.78e+00 | NA | 0.0e+00 | A2M,ABRA,ADGRE1,APOD,ATF3,ATP6AP2,ATP6V1E1,BDH1,C3AR1,C5AR1,CASP3,Ccl2,Ccl6,CCR1,CCR5,CCRL2,CEBPD,CISH,CLIC1,CLIC4,CNR1,CP,CRP,CXCR4,CYBB,EGR1,EGR2,FGF2,FGF9,FGFR1,GATM,GFAP,GPNMB,GPR65,HCAR2,HGF,HVCN1,IFI16,IGFBP7,IL1RN,IRF1,IRS1,KCNIP1,KCNK6,KLF4,LBP,LDB2,MSR1,MYF5,MYOD1,MYOG,NUDT6,Oasl2,OSMR,OXCT1,PCGF6,PDE10A,PENK,PPIB,PTGER3,PTGS2,RAB2B,REL,S100A6,Scd2,SCN2B,SLC15A3,SLC16A1,SOCS1,SOCS3,Sp100,SPP1,SREBF1,STAT1,TGFB1,TIMM9,TIMP1,TLR2,TLR7,VAV3,VIM,WNT5A,ZFP36 | 987 (15) |
| ITGAM | NA | transmembrane receptor | Inhibited | -2.78e+00 | NA | 2.0e-02 | BCL2A1,C5AR1,Ccl2,CD28,CD86,CXCL10,Foxp1,IRF3,PTGS2,TGFB1,TIMP1 | NA |
| IRF8 | -1.01e+00 | transcription regulator | Inhibited | -2.78e+00 | NA | 0.0e+00 | ACVRL1,ADGRE1,AHRR,AKAP12,ARID5B,ATF3,B2M,BANK1,BCL2L1,BCL6,CACNA1G,CASP3,CD37,CD74,CD83,CD86,CDKN1A,CFB,CIITA,CREM,CSF1R,CSF3R,CTSS,CUX2,CXCL10,CXCL16,CYBB,DAB2,DMPK,EGR1,EGR2,GFAP,ICAM1,IFI44L,IL17RA,IL1RN,IRF4,IRF5,IRF8,ISG15,KCNK6,KLF4,KLF6,MAF,MET,MSR1,MYH14,OAS3,Oasl2,PCDH7,Pmaip1,PRDM1,SOCS7,STAT1,STX11,STX3,TBX18,Tlr11,TLR4,TWIST2,ZEB2 | 1025 (16) |
| HDAC8 | 1.00e-01 | transcription regulator | Inhibited | -2.79e+00 | NA | 0.0e+00 | CDKN1A,FN1,HOXA5,MMP2,Pmaip1,SNAI1,SOCS1,VIM | 1367 (18) |
| norepinephrine | NA | chemical - endogenous mammalian | Inhibited | -2.79e+00 | NA | 0.0e+00 | ABCA1,ACTA1,ATP2A2,BDNF,CACNA1G,Ccl2,COQ10B,CREM,CSF1R,CXCR4,Dclk1,DCLK3,DUSP1,EDN1,EGR1,EIF2AK3,ELOVL1,FGF2,FN1,FOXP3,GPD1,GRK5,IRAK2,IRS2,LRRC73,MAN2A1,MAT2A,MMP2,MYH7,NFKBIA,NR4A1,NR4A3,PDE10A,PDE4D,PER1,PLAGL1,PPARG,PTCH1,PTGES,PTGS2,Rcan1,SERPINE1,SGK1,SLC2A1,SMAD7,SNAI1,TC2N,TGFB1,TINAGL1,USP33,WHRN | 1441 (20) |
| FGF8 | NA | growth factor | Inhibited | -2.80e+00 | NA | 0.0e+00 | AIF1L,BMP4,CCND1,CDK20,CMTM3,COL18A1,CRYAB,DDAH2,DUSP23,ELL2,ERRFI1,ETV5,FGF10,FGFR1,LHX8,LMX1A,MDK,MKI67,PCOLCE2,RGP1,RTN4RL1,RUNX2,S100B,SLC22A17,SLC27A3,SPARC,SPP1,THBS1,TNFRSF11B,TRIP6 | 1389 (25) |
| IL13 | NA | cytokine | Inhibited | -2.80e+00 | NA | 0.0e+00 | ABCA1,ACKR3,ACSL1,ACTA2,ADORA2A,AIF1,ALOX15,AMPD2,ARG1,ATF3,AVPI1,BATF,BCL2A1,BCL2L1,BCL3,BDNF,C3,C3AR1,CALCR,CASP1,CASP3,CASP8,CCDC186,Ccl2,CCL24,Ccl6,Ccl7,CCR5,CD101,CD36,CD37,CD44,CD48,CD86,CFI,CHI3L1,CISH,CLEC4A,COL18A1,COL1A1,COL3A1,CP,CSF2RA,CTNNAL1,CTSC,CTSH,CTSK,CTSS,CX3CL1,CXCL10,CXCR4,CYBB,CYSLTR1,DMBT1,DUSP10,EGR1,EGR2,EZR,F13A1,F3,FADS1,FADS2,FAM162A,FCGR1A,FCGR2B,FCGR3A/FCGR3B,FEZ1,FGD2,FLOT1,FN1,FZR1,G0S2,G6PD,GAS7,GPNMB,GPX3,HDC,HK1,HOMER2,HPSE,HRH1,ICAM1,IGF1,IL17A,IL1R1,IL1RL1,IL1RN,IRAK3,JAG1,KCNH2,KCNJ15,KITLG,KLF4,KLF6,LILRB3,LOXL4,LTBP1,MAF,MATK,MMP14,MMP2,MRC1,MRPL13,MSMO1,MTSS1,MYOD1,MYOG,NID1,NTN1,OCLN,PDGFC,PHLDA1,PLA2G2D,PLA2G4A,PPARG,PTGES,PTGS2,RHOA,RIPK2,SAMSN1,SELP,SERPINE1,SERPINF1,SLA,SNAI2,SNCA,SOCS1,SOCS3,SORT1,SPDEF,SPHK1,SPP1,ST14,ST3GAL6,ST8SIA4,STAT6,SWAP70,TGFB1,THBS1,TIMP1,TLR4,TNFRSF11B,TNFRSF1B,TP63,TRPV1,TYRO3,VCAM1,WNT5A | 1341 (15) |
| LOXL1 | -1.10e+00 | enzyme | Inhibited | -2.80e+00 | NA | 0.0e+00 | ACTA2,Ccl2,COL1A1,ELN,HIF1A,MMP2,SNCA,TIMP1 | 1266 (15) |
| USP1 | -6.10e-01 | peptidase | Inhibited | -2.80e+00 | NA | 0.0e+00 | FYN,ITGA5,ITGA6,LOXL2,S100A4,SPARC,TIMP1,USP1 | NA |
| trinitrobenzenesulfonic acid | NA | chemical reagent | Inhibited | -2.80e+00 | NA | 9.0e-02 | Ccl2,CCL24,Ccl7,CCR1,CCR5,CD44,CLDN1,COL1A1,COL3A1,CSF2RA,CXCL10,IL17A,LUM,NCF4,NR0B2,PTGS2,PTX3,Slco1a4,SOCS3,TGFB1,TIMP1 | NA |
| RARG | -6.40e-01 | ligand-dependent nuclear receptor | Inhibited | -2.80e+00 | NA | 0.0e+00 | ABCA1,ATP6V0A4,CHST10,CNR1,CRYAB,CYP26B1,DUSP1,EGR1,EGR2,ENOX1,FOLR2,FOXC1,GAP43,GATA4,HAS2,HOXA5,IGFBP6,KLF4,NR2F1,NTN1,PITX2,RARA,SALL4,SLC16A2,STRA6,THBD,UBA7 | 1508 (23) |
| PCDH11Y | NA | other | Inhibited | -2.80e+00 | bias | 2.0e-02 | AXIN2,BMP4,CCND1,CD44,ENO2,PTGS2,RET,SFRP2 | NA |
| CD2 | -3.30e-01 | transmembrane receptor | Inhibited | -2.80e+00 | NA | 2.8e-01 | CCNA2,CCND1,CD44,CD48,CD86,ICAM1,ITGAL,PTPRC,STAT1 | NA |
| BID | 0.00e+00 | other | Inhibited | -2.81e+00 | NA | 1.0e-02 | ADAM17,C3AR1,C5AR1,Ccl2,CTSH,CTSK,CTSS,TIMP1 | NA |
| cholesterol | NA | chemical - endogenous mammalian | Inhibited | -2.82e+00 | NA | 0.0e+00 | ABCA1,ABCA7,ABCG1,ACSL1,ACTA2,ADAM11,ADGRE1,ARG1,ATF3,C15orf48,CAMK1D,CASP1,CAV1,CAV2,Ccl2,Ccl7,CCR5,CNN1,COL1A1,COL3A1,CSF1,CTSK,CXCL10,CYBB,CYP27A1,CYP7B1,DHCR7,EPHX1,F3,FADS1,FCGR2B,FGF2,FN1,GLI1,GLI2,GNAI1,ICAM1,IL10RA,IL10RB,IL1RN,INHBA,KCNA5,KITLG,LEPR,LPL,MAP1LC3B,MAP2,MITF,MME,MMP14,MMP2,MSMO1,NCF2,NR0B2,NR4A1,NR4A2,NR4A3,PLTP,PPARD,PPARG,PPARGC1B,PTCH1,PTGS2,RGCC,RHOA,SLC1A3,SMO,SOCS3,SREBF1,STX3,TGFB1,THBS1,TIMP1,TLR4,TMEM123,Tpm1,UCP3,VCAM1,ZFPM2 | 1233 (16) |
| BMPR2 | -1.00e-02 | kinase | Inhibited | -2.82e+00 | NA | 0.0e+00 | CLIC4,CXCL12,EPHA4,FN1,ICAM1,ID2,INHBA,PTX3,RUNX2,SELE,SEMA3C,SNAI1,SPP1,TNFRSF11B,VCAM1 | 1320 (18) |
| lenalidomide | NA | chemical drug | Inhibited | -2.82e+00 | NA | 0.0e+00 | ACTG1,ANTXR1,AUTS2,BCL11B,CASP1,CAV1,CAV2,CCND1,CD226,CD244,CDKN2C,CITED2,CNKSR2,CTTNBP2,DNAJC25,DVL1,FKBP11,FLNA,FN1,FZD10,FZD2,FZD4,FZD5,GNPNAT1,GPR68,GZMB,HHATL,HLA-DQA1,HS3ST3B1,IFIH1,IGSF11,IRF4,IRF8,KLF4,LEF1,LHFPL2,LIMA1,LPL,LRRC4C,MAML2,MAN1C1,MAP2,MB,MMACHC,NEK6,NMI,NRP1,OTUD1,PLOD2,PROS1,PTPRC,RASSF4,RCAN3,REL,RNF213,RTP4,RYR1,SEC24A,SEMA5A,SNRPN,TLR4,TMEM33,TMEM64,UTRN,VIM,WDR4,WNT10B,WNT11,WNT2B,WNT4,WNT9A | 1587 (19) |
| IFNL4 | NA | cytokine | Inhibited | -2.82e+00 | bias | 0.0e+00 | CXCL10,DHX58,IFIH1,IFIT1,ISG15,MX1,OASL,STAT1 | 597 (10) |
| Am 580 | NA | chemical reagent | Inhibited | -2.83e+00 | NA | 0.0e+00 | APOD,CD1D,CNR1,CXCR5,CYP26B1,DUSP1,F3,FOLR2,IRF1,ITGA6,LRAT,LSS,MVK,MYCN,NTRK2,PLAT,PPARG,RARA,RARG,STRA6,THBD,TIMP1 | 1335 (21) |
| IRF9 | -2.50e-01 | transcription regulator | Inhibited | -2.83e+00 | NA | 0.0e+00 | CDH1,CIITA,CXCL10,F830016B08Rik,GBP7,HDC,HERC6,Ifi47,IFIT1,IFITM3,IRF1,IRF5,IRF8,ISG15,MX1,MYH7,NMI,OAS3,OASL,Oasl2,PARP14,RSAD2,RTP4,SLFN13,SOCS1,SOCS3,STAT1,USP18,ZC3HAV1 | 1313 (19) |
| lipoarabinomannan | NA | chemical - endogenous non-mammalian | Inhibited | -2.83e+00 | NA | 1.0e-02 | CCR5,CXCR4,ERBB3,ICAM1,IER3,IRF1,SELE,STAT1,TLR4 | 1430 (15) |
| sodium iodate | NA | chemical reagent | Inhibited | -2.83e+00 | bias | 2.0e-02 | CASP3,CASP8,MLKL,NCF1,NLRP3,NOX4,RIPK3,TRADD | NA |
| 1,1-diarylethylene-diammonium derivative | NA | chemical reagent | Inhibited | -2.84e+00 | NA | 0.0e+00 | BTG1,CCNA2,CCNE2,CDKN1A,CENPF,HERC6,ICAM1,IFI44,IFIH1,IFIT1,ISG15,NMI,OAS3,OASL,PARP14,PARP9,PLK1,SP110,SSPN,STAT1,UBE2L6 | NA |
| TEAD4 | 3.50e-01 | transcription regulator | Inhibited | -2.84e+00 | NA | 0.0e+00 | ACTA1,ACTA2,ADIPOQ,AK5,ARID5B,BMP4,CAV2,CBFA2T3,CCND1,CCNE2,CD34,CDH1,CDH2,CDK6,CDKN1A,CKM,COL3A1,COL5A2,Cox8b,EDN1,FGFR1,FIBIN,FKBP5,GLI2,HIF1A,IGFBP5,IRF6,KAZN,LIMCH1,LOXL1,MB,MMP2,MYH7,NFKBIA,NOTCH2,NRXN2,NUAK1,PCDH18,PDGFRL,PLIN1,PLK2,PPARG,PTPRO,RANBP1,RHOBTB1,SAMD5,SDC2,SH3D19,SNAI1,TAF1C,TAGLN,THBS1,TLE1,TNNC1,TNNT2,TP63,VIM | 1608 (22) |
| LLGL2 | 4.20e-01 | other | Inhibited | -2.84e+00 | bias | 0.0e+00 | ANKRD1,AXL,CDKN2C,DUSP1,EMP2,ETV5,FSCN1,FSTL1,ITGB2,SERPINE1,SGK1,SH2D4A,STMN1,TNNT2,TOP2A | NA |
| pembrolizumab | NA | biologic drug | Inhibited | -2.84e+00 | NA | 1.0e-02 | B2M,CASP3,CASP8,CD276,CD83,CMKLR1,FOXP3,GZMB,HLA-A,HLA-DQA1,IFIT1,IRF1,MKI67,PTGS2,STAT1 | NA |
| ADAM17 | -6.00e-01 | peptidase | Inhibited | -2.84e+00 | NA | 1.0e-02 | ACTA1,ACTG1,ADAM17,ANXA2,ARL6IP1,AXIN2,Ccl2,CCND1,CDC42EP4,CEACAM1,CLIC1,COL3A1,Crip2,DNAJA1,DUOX2,ERRFI1,FN1,GADD45G,IRF1,KRT19,LASP1,LRG1,MAP1LC3A,MMP2,MYCN,MYH7,PEA15,PLAT,PLIN3,RHBDF2,SOCS3,SPP1,STAT6,TNFRSF11B,WNT5A | 1484 (21) |
| SELP | -2.58e+00 | transmembrane receptor | Inhibited | -2.85e+00 | NA | 0.0e+00 | ADIPOQ,BCL2A1,CDKN1A,CLK1,CXCR4,CYP1B1,F3,GNA13,HCK,IGF1,MKI67,PRKCD,SELP,SERPINB9,STAT6,THBD | 1558 (18) |
| SENP3 | 3.90e-01 | peptidase | Inhibited | -2.85e+00 | bias | 1.0e-02 | CD86,CXCL10,CYTH1,H2-T22,H2-T24,HLA-A,IFI44,IL2RA,ISG15,OASL,Oasl2,RSAD2,SP110,STAT1,TDRD7 | 1088 (16) |
| Srgn | 2.90e-01 | other | Inhibited | -2.87e+00 | bias | 1.0e-02 | ADGRE1,CD300LF,CD83,CMA1,CXCL13,EGR3,FCMR,GEMIN8,GPR65,Mcpt4,RFX1,SERPINB8,SERPINB9,TBC1D10C,THBS1 | NA |
| CLEC4G | -3.00e-02 | other | Inhibited | -2.87e+00 | NA | 0.0e+00 | ARG1,CDK2,CDK6,CSF1,EBF1,EGR3,FGF1,FGF10,FZD4,IL17A,NOTCH4,NRARP,PDGFD,RSPO3,SFRP4,TGFB1,THBS4,VEGFC,WNT2,WNT2B | NA |
| MYB | NA | transcription regulator | Inhibited | -2.88e+00 | NA | 0.0e+00 | ANPEP,AXIN2,BANK1,BCL2L1,BHLHE40,BIRC3,C15orf48,C3,Ccl2,CCND1,CD34,CDH1,CDH2,CNN3,COX6A2,CXCL12,CXCL16,CXCR4,ENO2,EZH2,FN1,FOXO1,GIMAP7,GRAP,HIF1A,ICAM1,IGF1,IGFBP5,IKBKE,IL18R1,IL2RA,IQGAP1,ITGA2B,KDR,KIT,KITLG,KLF4,MAD1L1,MAT2A,MTSS1,NEDD9,NOD2,POLA1,PPP3CA,PRAG1,PTGS2,RBL1,RGCC,SDC1,SDC4,SLC16A3,SLC1A5,Slfn2,SNAI1,SNAI2,SPHK1,SPP1,TULP4,TWIST1,VIM | 1299 (19) |
| JAG1 | -1.07e+00 | growth factor | Inhibited | -2.88e+00 | NA | 0.0e+00 | ACTA2,APOD,CCND1,CCND2,CD86,CDKN1A,CLDN1,COL1A1,DTX1,DUSP1,DUSP10,DUSP5,DUSP6,ERBB3,GADD45A,GLI2,GPX3,HEY2,ITGB3,JAG1,LAMC2,NCAM1,NOTCH4,NR2F2,RNF128,RUNX2,SNAI1,SNAI2,SPP1,STAR,TAGLN,TGFB1,TIMM13,TNC,VIM,WNT4 | 1335 (17) |
| PI3K (family) | NA | group | Inhibited | -2.88e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACTA2,BCL2L11,BIRC3,CDH1,CXCL10,CXCL12,CXCR4,DDIT4,EGLN1,FBXO32,FOXO1,FOXO3,GCLC,GLI1,HIF1A,HK1,IFIT1,IL17A,ISG15,ITGA6,MMP2,NFE2L2,PDGFB,PKM,PREX1,PRKCZ,PTGS2,RDH10,RIPK3,SERPINE1,SIAH2,SLC2A1,SNAI2,SREBF1,THBS1,TNC | 1578 (19) |
| isoproterenol | NA | chemical drug | Inhibited | -2.88e+00 | NA | 0.0e+00 | ACSL3,ACTA2,ADIPOQ,ADRB2,ALOX15,APLN,APLNR,AQP4,ATF3,ATP1A1,BCL2L11,CASP1,CAV1,Ccl2,COL1A1,COL3A1,CREM,CYP1B1,EDN1,FGF2,GATA4,GRK5,LGALS12,LPL,MITF,MMP2,MYH7,MYOCD,NFATC4,NLRP3,NOS1,NR4A1,NR4A3,OSTN,PDGFB,PLAGL1,PLAT,PLP1,PNPLA2,PPP1R1A,PTGS2,RAB27A,RAB7A,TGFB1,TIMP1,TLR4,TPD52L2,TSHR,TUBB,TYRO3,VWF | 961 (15) |
| mycophenolic acid | NA | chemical drug | Inhibited | -2.89e+00 | NA | 0.0e+00 | ACTA2,ADRB2,AKAP12,ANPEP,ATF3,BIRC3,CCND2,CDK6,CDKN1A,CLDN1,CSGALNACT2,CXCR4,CYBB,DAPP1,DUSP1,EDN1,ETS1,FN1,ID2,IL17A,INHBA,KRT19,MME,MYBL1,OCLN,OLR1,PTGS2,RGS4,RUNX2,SERPINE1,UGCG | 1394 (18) |
| MAC | NA | complex | Inhibited | -2.89e+00 | bias | 0.0e+00 | CASP8,EGR1,EGR2,FGF1,FN1,IRF1,PTGS2,RGCC,SPP1,THBS1,TRADD,ZFP36 | 1178 (17) |
| POU5F1 | NA | transcription regulator | Inhibited | -2.89e+00 | NA | 0.0e+00 | ACKR3,ACVR1,ADORA2A,AHR,APCDD1,ATP6V0A4,B3GNT7,BCL2A1,BCL2L11,BIRC3,BMP4,BTG1,CARD6,CASP1,CASP3,CBFA2T3,CCNA2,CCND1,CDH1,CDH2,CDKN1A,CHST15,COBLL1,CXCL10,CXCL12,DAPK1,DUSP1,DUSP5,ECSIT,ESRRB,FABP1,FADD,FARP1,FRZB,FUCA1,GADD45A,GADD45G,GATA4,GBP4,GLI2,GM2A,GPI,HIF1A,HOPX,IER5,INHBA,IRF6,IRS1,KDM2B,KLF4,LAMP2,LBX1,LOXL1,MAX,MMP2,MYCN,NCAM1,NFATC4,NR2F2,NRP1,Oasl2,PCDH18,PCGF6,PDGFRA,PITX2,PMEPA1,POLE4,PROM1,PYCARD,RARA,RIPK2,SALL4,SIRPA,SMAD7,SNAI1,SNAI2,SOCS3,SPP1,TAF1C,TBX3,TDRD7,TFCP2L1,TGFB1,TNFRSF10A,TNFRSF11B,TNFRSF19,TNFRSF25,TNFSF8,TP53BP2,TWIST1,TWIST2,USP18,VIM,WEE1,WLS,WNT5A,ZEB2 | 1570 (23) |
| MAPT | -1.50e-01 | other | Inhibited | -2.90e+00 | NA | 0.0e+00 | A2M,ABCG1,ACO2,ACTA1,ACTG1,AIF1,ALDOA,AMIGO2,ANXA5,AP1B1,APOBEC1,ARF1,ATF3,ATOX1,ATP1B1,ATP6V1A,ATP6V1E1,B4GALT1,BCL3,BCR,BDNF,C1R,C3,C3AR1,CAMK2A,CAMK2D,CASP3,Ccl2,Ccl6,CCND1,CD22,CD44,CD48,CD74,CD84,CD9,CDK5R1,CDKN1A,CFAP126,CFL1,CFL2,CKMT1A/CKMT1B,CLTB,CORO1A,COX4I1,CP,CRYM,CST7,CTSC,CTSS,CXCL10,CXCL13,CXCL16,CYBB,DNAJC5,DOCK2,DPY19L3,DPYSL2,DPYSL3,EIF2AK3,EIF5A2,ELF4,ELOVL7,ENO2,EPHX1,EPSTI1,ERMP1,FCGR2B,FCGR3A/FCGR3B,FGR,FYN,GAD1,GAP43,GAPDH,GAS7,GBP2,GBP4,GBP5,GFAP,Ggta1,GLO1,GNG2,GPNMB,HBA1/HBA2,HIF1A,HINT1,HK1,HLA-A,HLA-DQA1,Hnrnpa3,HSP90AA1,HSPA1A/HSPA1B,HSPE1,ICAM1,IFI16,IFI44,IFITM3,IL1RN,ISG15,ITGA1,ITGA5,ITGB2,KLC1,LAMA3,LCP1,LDHB,LPL,Lrrc74b,LY86,MAP1A,MAP1B,MAP2,MAPK3,MDH1,MOG,MSN,MYO5A,NAPA,NDUFV2,NMNAT2,NOS1,NTRK2,OASL,Oasl2,OSMR,PARK7,PARP14,Pcp4l1,PDPN,PEA15,PEBP1,PENK,PGK1,PKM,PKP3,PLIN4,PPIA,PRDX5,PTPRC,PTX3,PVALB,RAB2A,RNF213,RPL23,RPS16,S100A6,S100B,SERPINE1,SERPINF2,SLAMF9,SLC16A3,SLC1A3,SLC1A5,SLC37A2,SLC38A3,SLFN13,SNCA,STMN1,SYNJ1,SYP,THBS1,THY1,TIMP1,TLR2,TM4SF1,TMCO4,Tpm1,TPPP,TRIM47,TUBA1A,TUBA8,TUBB,TUBB6,UBC,UNC13A,USP18,VCAM1,VIM,VSNL1 | 1450 (17) |
| IFIH1 | -6.80e-01 | enzyme | Inhibited | -2.90e+00 | bias | 4.0e-02 | Ccl2,CISH,CXCL10,EGR1,IFI44L,IFIT1,ISG15,NFKBIA,PHLDA1,PTPRJ,RND3,RSAD2,USP18,ZC3HAV1 | NA |
| cuprizone | NA | chemical toxicant | Inhibited | -2.90e+00 | NA | 0.0e+00 | ACER2,ACTC1,ADO,ALDH18A1,ANXA2,APBB1IP,ARHGDIB,ASPA,BCAS1,BDNF,Ccl2,Ccl7,CD86,CHI3L1,CIART,CNN3,CNP,CRYAB,CSPG4,CSRP1,CXCL10,DHRS1,EML1,EPHX1,FAM78A,FLNA,GFAP,GLUL,GPR34,HOMER1,HVCN1,IGF1,IRF8,LAMP2,LCP1,LEF1,LGALS1,MAG,MPP7,MSN,NCF1,NCKAP1L,NLRP3,NTM,PLP1,PRKCD,PTGS2,PTPRC,PYCARD,RPS24,SEMA7A,SH3BGRL,SLC37A2,SOCS3,Tlr13,TNNT1,VIM | 508 (7) |
| Ccl2 | -1.93e+00 | cytokine | Inhibited | -2.90e+00 | NA | 0.0e+00 | ADIPOQ,Ccl2,Ccl7,CCR5,CSF1,CTSK,CXCL10,CYBB,ETS1,HGF,IGF1,ITGB3,KDR,KLF4,LPL,PPARG,SDC4,SPP1,TBX3,TLR4,VCAM1 | 1177 (14) |
| ACVRL1 | -8.70e-01 | kinase | Inhibited | -2.90e+00 | NA | 0.0e+00 | ANGPT2,CDKN1A,CXCL12,CXCR4,ENG,ICAM1,ID2,IL1RL1,KDR,PLAT,SELE,SERPINE1,SMAD6,SMAD7,STAT1,TAGLN,TLR4,VCAM1 | 1145 (20) |
| KDM3A | 1.41e+00 | transcription regulator | Inhibited | -2.90e+00 | NA | 0.0e+00 | ACTA2,ALCAM,ARHGEF28,CCND1,CD9,EDN1,ETS1,GNG2,IL33,KLF5,LOXL2,PLOD2,PPP1R3C,SERPINE1,SLC45A3,TAGLN,TNC | 926 (7) |
| JUNB | 2.10e-01 | transcription regulator | Inhibited | -2.91e+00 | NA | 0.0e+00 | ATF3,BCL3,BDNF,C3,C3AR1,C5AR1,CAV1,Ccl7,CCND1,CD44,COL1A1,COL7A1,CXCL16,CYP1B1,Dgcr6,DUSP1,E2F7,FBLN5,FN1,FOXP3,ID2,IFI16,IKZF2,IL1RL1,INHBA,ITGB3,ITGB4,LPAR1,MMP2,MVD,NCF2,PENK,PLIN1,PNPLA2,RAB31,Raet1d/Raet1e,RASGRF1,ROCK1,RUNX2,SERP1,SERPINE1,SGK1,SLC7A1,SNAI1,SNAI2,STAR,SWAP70,TBX3,TIMP1,TNFRSF8,VEGFC | 1447 (19) |
| mir-223 | NA | microRNA | Inhibited | -2.91e+00 | NA | 0.0e+00 | ABCA1,ACTA2,ALCAM,AMPD3,APOBEC1,C15orf48,C5AR1,CACNA2D2,CAMKK1,CARD11,CCND1,CCR3,CD180,Cd33,CD34,CD36,CD93,CSF1,EGF,EGR2,EGR3,EMP1,EYA1,FAM20C,FGL2,FOXO1,FOXO3,GPR65,HIF1A,HLA-DOB,ICAM1,ID2,IFI16,IGF1,IL1RN,INPP5J,LEF1,LMO2,LPL,MCTP2,MLKL,MSMO1,MYO1D,MYOF,NKX6-1,NLRP3,RAB38,RIPK3,S100A6,SLC16A7,SMOC1,SOAT1,SOX6,STMN1,TGFBI,Tlr13,TLR4,TLR7 | 1567 (23) |
| rifampin | NA | chemical drug | Inhibited | -2.91e+00 | NA | 1.0e-02 | ABCC3,ABCG1,ALDH1A1,AXIN2,BMP1,CD36,CDCA7L,CEP70,CFL1,CRYAB,CSF1,CTNNAL1,CXCL10,CYP4B1,DSE,ECT2,ELAVL1,GBP2,LAMA3,LCAT,MAOB,MATN2,MME,NAGK,NR0B2,PNRC2,RGS10,SLC39A10,SPP1,STYX,TBC1D9,TGIF2,TLR2,TNFRSF11B,TSKU,TWF2,UGT1A4,USP18 | 1394 (24) |
| Stat1 dimer | NA | complex | Inhibited | -2.92e+00 | bias | 1.0e-02 | CD36,CIITA,CXCL10,CYBB,DUSP1,FCGR1A,IRF1,IRF8,SOCS3 | NA |
| SAMSN1 | -9.70e-01 | other | Inhibited | -2.92e+00 | NA | 0.0e+00 | ARID5A,BATF,Ccl7,CCND2,CITED2,CXCL10,DAB2,EDN1,FGL2,HDC,IL15RA,INHBA,IRF1,ISG15,NMI,OASL,PLA1A,PLAT,PTGS2,RBL1,RGCC,RILPL1,RSAD2,SAP30,SDC1,SLCO3A1,SOCS1,SOCS3,STAT1,TNFSF8 | 738 (10) |
| NOD2 | -1.54e+00 | other | Inhibited | -2.92e+00 | NA | 1.2e-01 | ACSL1,AXIN2,BCL2A1,CXCL10,DMBT1,Ggta1,ICAM1,IER3,IL17A,MARCKSL1,NFKBIA,PTGES,RALGDS,RASGRP1,SOCS3,TWIST1,TWIST2 | NA |
| enterotoxin B | NA | biologic drug | Inhibited | -2.93e+00 | bias | 2.0e-02 | BDNF,BPGM,Ccl2,CCL24,Ccl7,CDR2,CSF2RA,CSF2RB,CXCL10,CXCL12,CXCL13,CXCR4,GPNMB,ICAM1,IL10RB,IL17A,IL2RA,IL33,LY75,RSAD2,SNCA | NA |
| TLR9 | -3.40e-01 | transmembrane receptor | Inhibited | -2.93e+00 | NA | 0.0e+00 | ABCA1,ATF3,BCL2L1,Ccl2,Ccl7,CCNA2,CCND1,CD83,CD86,CDK2,CERS6,CISH,CSF1,CXCL10,DUSP1,EDN1,EGR1,FCMR,FLT3LG,GADD45B,GCH1,ICAM1,IER3,IFI16,IFI44L,IFIT1,IL10RA,IL17A,IL2RA,IL33,IL4I1,IRF1,IRF4,ISG15,KDELR3,LAMP2,LIPG,LIX1,LYST,MX1,NR0B2,NR4A1,NTS,OAS3,Oasl2,PFKFB3,PHLDA1,PRDM1,PTGS2,PYCARD,RAB7B,RSAD2,SDC1,SERPINE1,SMPDL3B,SOCS1,SOCS3,SPHK1,STAT1,TGFB1,TIMP1,TLR4,TLR7,TNC,TNFRSF1B,UAP1,UGCG,USP18,VAV2 | 1231 (16) |
| ceruletide | NA | biologic drug | Inhibited | -2.94e+00 | NA | 2.0e-02 | ACTG1,ADAM17,ANXA2,ARHGEF2,ARL6IP1,Ccl2,CDC42EP4,CEACAM1,CLIC1,Crip2,DNAJA1,ERRFI1,GADD45G,IL33,IRF1,KRT19,LASP1,MAP1LC3A,MME,PEA15,PLIN3,PTGS2,SELP,SMAD6,SOCS3,SPP1,STAT6 | NA |
| MKNK1 | 4.90e-01 | kinase | Inhibited | -2.94e+00 | bias | 0.0e+00 | ACOT7,ADAMTSL3,ANXA2,ANXA5,CAMK2A,CD34,CFH,COL4A6,CP,DMP1,DPYSL3,EEF1D,EGR1,ETS1,FLNA,GAP43,GGCT,GLDN,GNAI1,HS6ST2,HSD17B4,HSPA2,ID2,IFI16,ISG15,ITM2A,KIF21B,KIF5A,KLC1,MAN2A1,MAP1B,MYO5A,NCDN,NR4A3,NRCAM,NUP210,PDK4,PLA2G4A,PLTP,Rab15,Scd2,SERPINH1,SFRP1,SLITRK6,SPARC,TAGLN,VIM,VSNL1 | 524 (7) |
| PDGFB | -7.90e-01 | growth factor | Inhibited | -2.94e+00 | NA | 0.0e+00 | ACTA2,CCND1,CNN1,COL1A1,COL3A1,EGR1,FGF1,FGF10,FN1,FOXO1,FOXO3,HDAC7,ICAM1,IL1RN,KCNA5,mir-143,MMP2,NOTCH2,NR4A1,PHLDA1,PTGS2,RIPK3,S1PR2,SERPINF1,SPP1,THBS1,TIMP1,TNC | 1414 (21) |
| ribavirin | NA | chemical drug | Inhibited | -2.96e+00 | NA | 1.5e-01 | CD86,IFI44L,IRF1,ISG15,ITGB2,MX1,OASL,RSAD2,STAT1,USP18 | NA |
| Pam3-Cys-Ser-Lys4 | NA | chemical reagent | Inhibited | -2.96e+00 | NA | 0.0e+00 | ADGRE5,ANGPT2,AOX1,BATF,BCL2A1,BCL2L1,BCL2L11,BDKRB2,CASP8,Ccl2,Ccl7,CCR1,CCR5,CD180,CD83,CD86,CLDN1,CSF1R,CX3CL1,CXCL10,CXCL13,F2RL1,F3,FCGR2B,HIVEP3,HLA-A,ICAM1,IER3,IFI16,IL17A,IL2RA,IRF1,IRF4,ITGA4,ITGB7,KLHL21,MAPK3,MMP2,NFKBIA,NLRP3,NOD2,PARP14,PRDM1,PTGES,PTGS2,REL,RGS2,SELE,SELP,SERPINE1,SLC16A3,SLC2A1,SNCA,STAT1,TLR2,TLR4,VCAM1 | 1156 (13) |
| MESP1 | -9.00e-02 | transcription regulator | Inhibited | -2.97e+00 | bias | 0.0e+00 | FOXC1,FOXC2,GATA4,MYOCD,SNAI1,SNAI2,TWIST1,TWIST2,ZEB2 | NA |
| MAPK14 | 1.23e+00 | kinase | Inhibited | -2.97e+00 | NA | 0.0e+00 | ABCA1,ACP5,ACTA1,ACTA2,ADCY7,ANKRD1,ATF3,ATP2B4,AXIN2,BTG2,Ccl2,Ccl7,CCNA2,CCND1,CD36,CD74,CD83,CD86,CDH1,CEBPD,CKM,COL1A1,CRP,CRYAB,CXCL10,DAB2,DLL1,DUSP1,DUSP6,ELAVL1,F3,FN1,GADD45A,GNAS,GREM1,HAS2,HLA-DQA1,HTR7,ICAM1,JUND,KDR,KITLG,LEF1,MAOB,MAPK14,mir-133,MYH6,MYOG,NRP1,PLA2G5,Pmaip1,PPARGC1B,PRDX1,PTGES,PTGS2,RUNX2,SGK1,SIGIRR,Slfn2,SOCS3,SPHK1,SPP1,SREBF1,TAGLN,TGFB1,TIMP1,TLR2,TOP2A,Tpm1,Tpm3,TRPV1,VCAM1,VEGFC,ZFP36 | 1601 (18) |
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | NA | chemical toxicant | Inhibited | -2.97e+00 | NA | 0.0e+00 | ADGRE1,AIF1,ANXA2,BACH1,BDNF,CALB1,CASP1,CASP3,CASP8,Ccl2,CLDN1,CLK1,CNR1,CSF1,CSF1R,CYBB,EGR1,EGR3,FGF2,FKBP5,FSTL1,FUBP1,GFAP,HOMER1,Klf16,LMCD1,MAP2,MAP2K4,MVD,NCF2,NLRP3,NOS1,NR4A1,NR4A2,NRARP,PARK7,PAWR,PDGFRA,PENK,PLEKHF1,PTGS2,PTPRC,PVALB,PYCARD,RHOA,SGK1,SLC25A34,SNCA,TLR4,TNFRSF1B,ZBTB16 | 1097 (12) |
| NSUN6 | -1.70e-01 | enzyme | Inhibited | -2.98e+00 | bias | 0.0e+00 | AXL,CDKN2C,DAB2,DDAH1,EMP2,ETV5,FGF2,FLNA,FSCN1,FSTL1,ITGB2,PHGDH,PMP22,SERPINE1,SGK1,STMN1,THBS1,TNNT2,TOP2A | NA |
| IL17RA | -7.70e-01 | transmembrane receptor | Inhibited | -2.98e+00 | NA | 1.2e-01 | Ccl2,CCR1,CSF3R,CXCL12,IL17A,SDC2,SELE,SELP,TIMP1 | NA |
| JAK1 | 2.00e-02 | kinase | Inhibited | -2.99e+00 | NA | 0.0e+00 | BCL2L11,BCL3,CDKN1A,CHI3L1,HIF1A,HLA-A,ICAM1,IRF1,LRG1,MMP2,MX1,MYOD1,Oasl2,OSMR,PDGFB,RUNX1,SFTPB,SLC1A3,SMAD7,SNAI1,SOCS3,STAT1,TGFB1,USP18 | 974 (14) |
| 5-fluorouracil | NA | chemical drug | Inhibited | -2.99e+00 | NA | 0.0e+00 | ACVR1B,AEN,ALDOA,ANKRA2,ANXA2,ATF3,BAIAP2,BCL2L1,BCL2L11,BTG2,CALU,CASP3,CCND1,CCND2,CD86,CDH1,CDK2,CDKN1A,COX6B1,CSF1R,CSTB,CSTF1,CTSE,DLL1,DRAM1,EGR1,EIF3C,EIF3G,FOXO1,GADD45A,GAP43,GAPDH,HNRNPC,HRAS,HSPE1,IER5,IP6K2,ITGB4,MAD1L1,MAT2A,MDH1,mir-133,NDUFA1,NDUFV2,NINJ1,NNT,OAZ1,OGT,PGK1,PIK3CG,PKM,PLK2,PLK3,PRC1,PSMA6,PSMB1,PSMB5,PTGS2,RBL1,RGS7,RHBDF2,RPL18,RPL23,RPL35,RPL36,RPL6,RPS15A,RPS16,RXRA,SDC1,SESN1,SKP2,SLA,SLC25A6,SNAI1,SNAI2,SPHK1,SPP1,TGFA,TGFB1,THBS1,TLR4,TMSB10/TMSB4X,TYMS,ZFP36L1 | 1510 (21) |
| carboplatin | NA | chemical drug | Inhibited | -3.00e+00 | NA | 0.0e+00 | A2M,A3GALT2,ASNS,Bex2/LOC100912195,CASP3,CD44,CD47,CP,GCGR,GPNMB,HAS2,IER3,LAMC2,MRC1,PLA1A,SPP1,TIMP1,TUBB,VIM | 794 (11) |
| CD38 | -1.00e-02 | enzyme | Inhibited | -3.00e+00 | NA | 0.0e+00 | ACTA2,ALDOA,ANXA2,ASNS,ATP1B1,BCL6,CCND2,CD44,CD86,CISD1,CISH,CITED2,CKAP4,CLCN3,COL1A1,CPEB3,CSF2RB,CYBB,EGLN1,EIF4EBP1,ELL2,FAM162A,FGL2,FN1,GADD45G,GBE1,GBP2,GBP4,GBP7,GLIPR2,GPAM,ICAM1,IL2RA,ITGB7,MYADM,NABP1,NCAM1,NFIL3,NOX4,PDLIM1,PGM1,PKIB,PKM,PPP3CA,PRDM1,PRDX4,RAP1GAP,RASGRP2,S100A4,S100A6,SAP30,Scd2,SDC1,SEMA4A,SKA1,SLC16A3,SLC2A1,SLC39A8,SOCS1,SOCS3,TGFB1,THY1,TMED5,VCAM1,VIM | 1542 (20) |
| DSCAM | -2.00e-01 | other | Inhibited | -3.00e+00 | NA | 0.0e+00 | ARHGAP4,DAB1,ELMO1,ETV5,FRK,GADD45G,IRS1,JAK3,KCNA2,KCNK6,KLF4,KLF9,L1CAM,LIX1,MAP2,MICALL2,NGEF,NOS1,NRCAM,NTN4,NTNG2,NTRK2,PCDH17,PDGFB,PLCB1,PLD1,PRKCB,RET,RGMA,ROBO2,SEMA3E,SEMA7A,SFRP1,SFRP4,SLC1A1,SNCAIP,TAL1,TUBB4A,UNC5A,VIM,WNT16 | NA |
| TASL | NA | enzyme | Inhibited | -3.00e+00 | bias | 2.0e-02 | BCL2A1,EPSTI1,GBP4,GBP5,IFIT1,OASL,TNFAIP6,USP18,VCAM1 | NA |
| Eldr | NA | other | Inhibited | -3.00e+00 | bias | 2.0e-02 | BUB1,CCNA2,CENPF,DEPDC1,ESPL1,IQGAP3,KIF11,KIF23,KIF4A,MKI67,NCAPG,PLK1,PLK4,SPC25,TACC3,TOP2A | NA |
| SKP2 | -1.15e+00 | other | Inhibited | -3.00e+00 | NA | 0.0e+00 | CCND1,CCND2,CDH1,CDH2,CDK2,CDKN1A,EZH2,FOXO3,FOXP3,NFATC4,RHOA,S100A4,SKP2,SLC2A1,TWIST1,USP18,VIM,ZEB2 | 1503 (20) |
| HTT | 2.50e-01 | transcription regulator | Inhibited | -3.01e+00 | NA | 0.0e+00 | ABCA1,ACTA1,ACTA2,ACTN2,ADAMTS2,ADAMTS5,ADORA2A,AKAP12,ALDOA,AMD1,ATF3,ATP1A1,ATP2A2,ATP2B3,B2M,B3GNT2,BAIAP2,BCL11B,BCL2L11,BCL3,BCL6,BDNF,BHLHE40,BMP1,BMP3,BTG3,C1QTNF3,C1R,CA12,CAMK2A,CASP1,CASP3,CCND1,CD74,CD9,CDH11,CDK2,CDKN1A,CHKA,CHRNA1,CIT,CITED2,CKM,CLDN1,CLIC6,CNR1,COL16A1,COL18A1,COL6A3,CORO2B,COX4I1,COX6A2,Cox8b,CREB1,CRYAB,CSF1R,CX3CL1,CXCR5,DBNL,DBP,DCN,DHCR7,DKK3,DLG3,DLL1,DNAJB1,DNM1,DUSP5,DUSP6,EBF1,EDNRB,EEF1A1,EGR1,EGR2,EMP3,ENO2,ENO3,EPB41L3,Esrra,ESRRB,ETV1,FGF1,FGFR1,FHL1,FN1,FOXO3,Foxp1,FXYD6,GAD1,GADD45G,GAP43,GAPDH,GAS7,GCLC,GFAP,GJC1,GLO1,GLUL,GNAL,GNB5,GPI,GPR88,GPX3,GRIN2D,GRK5,GSR,HAP1,HAPLN3,HBA1/HBA2,HIF1A,HOMER1,HRAS,HSPE1,IFI16,IGFBP5,KCNA1,KCNC4,KCNJ12,KCNK2,KCNK3,KCNQ2,Klf16,KLF4,KLF5,KLF9,LDHB,LOX,LTBP2,MAN1A1,MAP2,MICU1,MMP14,MMP2,Mt1,MYL1,MYL2,MYOD1,NAB2,NCS1,NDUFA1,NDUFA7,NDUFS7,NEFL,NFE2L2,NFIL3,NGEF,NOS1,NR1D2,NR2F1,NR4A1,NR4A2,NSG2,NTRK2,NTS,PC,PCTP,PDE10A,PDK2,PDLIM4,PEA15,PENK,PER1,PFN1,PLCB1,PPARD,PPARG,PPARGC1B,PPP1R1A,PPP3CA,PPP5C,PRELP,PRKAA2,PRKCB,PRKCD,PROM1,PVALB,RABIF,RAP1GAP,RARA,RASD2,RASGRP2,RGS14,RGS4,RIPK2,RXRG,SART1,SCAMP5,Scd2,SELENOP,SERPINF1,SERPING1,SERPINH1,SESN1,SFRP1,SGK1,SGTA,SIRPA,SLC1A3,SLC25A22,SLC2A1,SMC2,SNCA,SORT1,SPP1,SPTBN2,STMN1,STX4,SYP,TAGLN,TESC,TGFBI,THBS2,TM4SF1,TNNI2,TUBB,TYRO3,UBE2G2,UBE3A,UQCR11,VCAM1,VEGFD,VIPR2,VSNL1,VTI1B | 1625 (22) |
| AGN194204 | NA | chemical drug | Inhibited | -3.01e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ADAM19,ADIPOQ,AHR,Akr1b7,ANXA2,ATF3,ATP1A1,BCL2A1,CA3,CAMK2D,CCNA2,CD6,CDKN1A,CDKN2C,CHKA,CLIC4,COTL1,Crip2,CSRP1,CYP26B1,CYP7B1,DCN,DHCR7,DOCK8,DUSP1,EBF2,ELOVL5,EMP1,EMP3,ENO3,EZH2,F2RL1,Fmnl1,Foxp1,GADD45A,GAPDH,GBP2,GGCT,GNAI1,GNAS,GPR65,HIC1,Hmgn2 (includes others),HTRA3,Ifi47,IFITM3,IL17A,IL2RA,IL2RB,IL33,IRF1,IRS2,ITGB2,ITGB7,ITM2A,KIF4A,KLF6,LGALS1,LPL,LSS,MAN1A1,MITF,MKI67,NGEF,NRXN2,PARM1,PDK4,PENK,PHLDA1,PLIN4,PLK1,PPARG,PRC1,PROS1,RCAN2,RCAN3,RGS10,Scd2,SLCO4A1,SMC2,SNTB1,SPN,SPP1,STAT5B,STRA6,TIMP1,TOP2A | 1443 (21) |
| cyclic AMP | NA | chemical - endogenous mammalian | Inhibited | -3.01e+00 | NA | 0.0e+00 | ABCA1,ACTA2,ADRA2A,AFAP1L2,Akr1b7,ANTXR1,ANTXR2,ARG1,BDNF,CCND1,CCND2,CD86,CDH2,CDKN1A,CEBPD,CREB1,CREM,CRYAB,CRYM,DUOX2,EGR1,EGR2,ENO2,ENTPD1,F3,FCGR1A,FGF2,FN1,GAP43,GATA4,GCH1,HIF1A,IGF1,IGFBP4,IGFBP5,IL1RN,IL2RA,IL33,INHA,INHBA,KCNA1,KCNJ13,KDR,KIF23,MITF,MME,NOS1,NR4A1,NR4A2,NR5A1,PDE4D,PENK,PER1,PFKFB1,PLA2G4A,PNMT,PRKAR2B,PTCH1,PTGS2,RARA,RXRA,SERPINE1,SLC2A1,SLC37A4,SOCS3,SREBF1,STAR,STAT1,SYP,TGFA,THBD,TIMP1,TPH1,TRPV4,TSHR,UCN,VWF,WNT10B | 1377 (21) |
| lithium chloride | NA | chemical drug | Inhibited | -3.02e+00 | NA | 0.0e+00 | AHR,AXIN2,B4GALT1,BCL3,BMP4,CACNA1G,CCND1,CD44,CDKN1A,CKM,DCN,DLK1,EZH2,FSCN1,GATA4,GFAP,LEF1,LSS,MAP1LC3B,MMP2,MYOD1,MYOG,Naip1 (includes others),NKD2,PER1,PLD1,PPARG,PRKCD,PTGS2,PTX3,RARA,RSPO1,SNAI1,TAGLN,TBX5,VCAN | 1461 (17) |
| BTNL2 | NA | transmembrane receptor | Inhibited | -3.02e+00 | NA | 0.0e+00 | ACTR3B,CD109,CD74,CDKN2C,CHD7,CNN3,CYP2S1,DAPP1,EMB,ENAH,ENTPD1,FGL2,FGR,FOXP3,GBP4,GJB2,GPD2,GPR34,IFITM3,IKZF2,IL17A,IL1RL1,ITGAE,KCNK6,MYO10,NCOA7,PLXDC1,RALGDS,S100A4,SEMA4F,SPECC1,ST14,TMEM64,TNFRSF1B | 969 (10) |
| MAP3K1 | NA | kinase | Inhibited | -3.02e+00 | NA | 0.0e+00 | ATF3,BIRC3,CCND1,COL3A1,DUSP1,EGR1,IKBKB,IRF3,MAN2B2,MAOB,MYH2,PLA2G4A,PPARD,PRDX1,PTGS2,RGS4,RGS7,SERPINE1,TGFB1,THBS1,TIMP1,TNC,TNFRSF10A,TOP2A,TPH1 | 1249 (17) |
| ATF2 | 1.40e-01 | transcription regulator | Inhibited | -3.02e+00 | bias | 0.0e+00 | ASNS,ATF3,BCKDHA,BCL2A1,BCL2L1,CCNA2,CCND1,DMBT1,DUSP1,DUSP10,DUSP5,EGR1,ENTPD1,FN1,GADD45A,IL1RL1,MAPK14,MAT2A,MYH7,NTS,PDGFRA,PENK,PPARG,PTGS2,SNAI2,TSHR,VCAM1 | 1478 (17) |
| IRF5 | -1.01e+00 | transcription regulator | Inhibited | -3.02e+00 | NA | 0.0e+00 | BCL2L1,CASP3,CCL21,CDKN1A,COL1A1,COL3A1,CXCL10,CXCR4,DHX58,FOXO1,IFI44,IFIH1,IFIT1,IFITM3,IRF5,ISG15,OASL,Oasl2,PRDM1,PTGS2,RSAD2,SP110,STAT1,TGFB1,UBE2L6 | 1065 (17) |
| OTX2 | NA | transcription regulator | Inhibited | -3.03e+00 | NA | 0.0e+00 | A2M,BEST1,BMP4,COL8A1,CPXM2,EFNA5,FLVCR2,GPNMB,MITF,MYOD1,NCAM1,PRDM1,PTPRZ1,RDH10,RDH5,SEMA3C,STRA6,THBS4,TNC,TRPM1 | NA |
| abemaciclib | NA | chemical drug | Inhibited | -3.04e+00 | NA | 0.0e+00 | ABHD15,APOD,CDK6,CEACAM1,ISG15,LAMA3,MR1,NTN1,PCSK5,PLAT,PLTP,PLXNB1,TGFA,TGFBI,TSKU,VWCE | NA |
| E. coli serotype 0127B8 lipopolysaccharide | NA | chemical - endogenous non-mammalian | Inhibited | -3.04e+00 | NA | 0.0e+00 | ADGRA1,ADGRG2,ADIPOQ,ADRA2A,AIF1L,ANXA1,BCAN,BDNF,CASP8,CAV1,Ccl2,Ccl7,CCRL2,CHST11,CHST7,CXCL10,CXCL12,CXCL16,CXCR4,EDEM1,EDNRB,EGR2,ELN,F2R,F2RL1,FAM107A,FGF1,FGF2,FZD1,FZD2,GJA5,GJB2,GLDN,GLUL,GNA13,GNB4,GNB5,GNG2,HAS2,HCAR2,Ifi47,IGF1,IL7,IRF1,IRF3,IRF5,ITPK1,LAMC2,LOX,LPAR4,NFKBIA,NTRK2,P2RY1,P2RY6,PANX1,PDGFB,PRDX5,PTGES,PTGS2,PTX3,RSAD2,SEMA4A,SEMA7A,SOCS3,STAT1,TLR2,TLR4,TNFRSF11B | 1149 (13) |
| 5-O-mycolyl-beta-araf-(1->2)-5-O-mycolyl-alpha-araf-(1->1’)-glycerol | NA | chemical - endogenous non-mammalian | Inhibited | -3.05e+00 | NA | 0.0e+00 | ACSL1,ADAMTS5,ADORA2A,ATF3,BCL2A1,BCL3,CD1D,CD44,CD83,CHST7,CMKLR1,CX3CR1,CXCL10,DUSP1,EGR2,GPAT3,ICAM1,IER3,IFIT1,NR4A3,PCSK5,PLA2G7,PTGS2,RND3,SDC4,SOCS3,SPHK1,VCAM1 | 985 (12) |
| PTH | NA | other | Inhibited | -3.05e+00 | NA | 0.0e+00 | ADAMTS1,ADD3,ALOX15,ATP2A2,BHLHE40,CALB1,Ccl2,CCND1,CDKN1A,CGNL1,CLEC11A,Clec2d (includes others),COL1A1,COL2A1,CREM,CSF1,CXCL12,CXCR4,CYBA,DMP1,DUSP1,EGR2,EIF2AK3,FN1,HDAC4,ID4,IGF1,IGFBP5,IL33,LEF1,LIMA1,MME,MMP2,NFIL3,NR4A1,NR4A2,PALM,PDK4,PHLDB2,PPP1R1A,PTGS2,RAP1GAP,RGS2,RUNX1,RUNX2,SDC4,SFRP2,SFRP4,SLC9A3,SMAD7,SNX3,SOCS3,SORT1,SPP1,ST14,TFPI2,TGFB1,THBS4,TMEM119,TNFRSF11B,WNT10B,WNT4 | 1259 (19) |
| TMPRSS2-ERG | NA | fusion gene/product | Inhibited | -3.06e+00 | NA | 0.0e+00 | ARHGAP28,C15orf48,CARD6,CBX2,CDH1,CHAC1,COL27A1,COL5A1,CREB3L1,CYBA,DDIT4,DPYD,FAP,FHOD3,FSCN1,GNB4,GNG11,HCAR1,IFI44,IGFBP6,INHBA,KLF9,LAMA3,LONRF2,LOXL2,LPL,LTBP2,MME,MSLN,OASL,PHLDA1,PLAT,PPARG,SFRP1,SUMO3,TCEA3,TGFBI,THBS1,TLR2,TNNC1,TSPAN2,VEGFC,VIM,ZEB2,ZNF503 | 1259 (12) |
| collagen type i (family) | NA | group | Inhibited | -3.06e+00 | NA | 0.0e+00 | CDH2,CFL2,HTR2B,IL1RN,LUM,MMP19,MSR1,SERPINE1,SNAI1,SPARC,TGFB1I1,TWIST1,TWIST2 | 953 (13) |
| IFI16 | -1.30e+00 | transcription regulator | Inhibited | -3.06e+00 | NA | 1.0e-02 | CCND1,CD28,CDKN1A,CSF3R,CXCL10,E2F2,EDN1,FOXP3,GADD45A,GATA4,ICAM1,ID2,IFI16,IL1RN,IL2RB,ISG15,LPL,MGST1,MTHFD2,NFKBIA,SELE,UCP3,VCAM1 | NA |
| IFN alpha/beta | NA | group | Inhibited | -3.06e+00 | NA | 0.0e+00 | ARHGEF10,AXL,BCL2L11,CCL24,CCRL2,CD83,CD86,CX3CL1,CXCL10,CXCL14,CXCL16,FGL2,GAS7,HLA-A,IFI16,IL15RA,IL7,IRF1,IRF8,ITGA2B,MRC1,Pmaip1,RNF213,RSAD2,SERPINB9,SOCS1,Sp100,STAT1,TLR2,TLR5,TLR7 | 1040 (16) |
| MASTL | -4.40e-01 | kinase | Inhibited | -3.07e+00 | NA | 2.0e-02 | ACVR1,ARHGDIB,ARHGEF2,ATP2A2,CDK6,CYP1B1,DUSP11,MYH10,PRKAA1,RAC2,SERPINE1,SNTB2,TUBB6,UBQLN2 | NA |
| testosterone | NA | chemical - endogenous mammalian | Inhibited | -3.08e+00 | NA | 0.0e+00 | A2M,Abca8a,ACSL1,Actn3,ADIPOQ,ADRA2A,Akr1b7,ALDOA,AMD1,AMHR2,ANKRD1,ANPEP,ANXA1,APLN,ATP1B1,ATP2A2,ATP6V1F,BCL2L1,BCL3,BDNF,BGN,BMP15,BMP4,CA3,CASP3,CASP8,CAV1,CCND1,CDH1,CDH2,CDK2,CDK6,CDKN1A,CIZ1,CLCN3,COL3A1,COX6A2,CRHR2,CRP,CYP26B1,CYP7B1,DCN,DDIT4,EGF,EGR1,EIF2AK3,EIF4EBP1,ERBB3,FADD,FAM89B,FBXO32,FGF10,FGFR1,FN1,FOXO1,GADD45A,HCN4,HDC,HIF1A,HSPA1A/HSPA1B,IGF1,IGFBP5,IL33,INHBA,INHBB,IRS1,IRS2,JUND,LGALS1,LOC100359583/Ptma,MAL,MGST1,MSTN,Mt1,MX1,MYOD1,MYOG,NFKBIA,NOS1,NR5A2,OCLN,PDAP1,PDE3B,PDE5A,PDIA4,PIK3R1,PKIB,PMP22,PPARG,PRKCB,PRKCE,PRKCZ,PSMB1,PTCH1,PTGS2,RAB2A,RARA,RARG,RIMS2,RPS11,SBDS,SDC1,SELP,SLC39A8,SLC6A9,SLC9A1,SNCA,STAR,STEAP2,STX3,SYK,TBXAS1,TEK,TGFA,TGM4,THBS1,TLR4,TNFRSF11B,TOP2A,TRIM63,UGT8,VCAM1,VCAN,WNT5A | 2045 (22) |
| KDM5A | -2.20e-01 | transcription regulator | Inhibited | -3.09e+00 | NA | 0.0e+00 | ACO2,ACTC1,ACTN2,Actn3,ATP1A1,ATP1B1,ATP6V1F,BCKDHA,CCND1,CHRNA1,COQ7,COX14,COX4I1,COX6B1,DMPK,GADD45GIP1,GHITM,GPT2,HOMER1,MAPK4,MDH1,MRPL53,MRPL58,MRPS23,MYBPC1,MYH2,MYH6,MYH7,MYH8,MYL1,MYOM2,NDUFS7,NDUFV1,PARK7,PGAM2,RPS6KB1,RYR1,TIMM50,TNNC1,TNNC2,TNNI2,TNNT1,TNNT2,TOMM6,TOMM7,Tpm1,WNT6 | NA |
| deoxycorticosterone acetate/potassium chloride/sodium chloride | NA | chemical reagent | Inhibited | -3.09e+00 | NA | 0.0e+00 | Akr1b7,ATP6AP2,Ccl2,CCR5,COL1A1,CYBB,FN1,NOS1,NOX4,NR2F2,PDE5A,PTGS2,SPP1 | 1216 (17) |
| ERG | -2.00e-02 | transcription regulator | Inhibited | -3.09e+00 | NA | 0.0e+00 | ABCC4,ACOT8,ADRB2,ALOX12,ARHGAP24,ARHGAP28,ARHGAP4,ARHGEF2,AXIN2,BCR,BIRC3,CAMK1D,CCNA2,CDH1,CDH2,CLDN1,CNR1,CUX2,CXCR4,DAAM1,DBN1,DIAPH3,DNMBP,DOCK10,DOCK2,ELMO1,EPB41L3,ETS1,EXT1,EZH2,F2R,FHL1,FKBP5,FMNL2,FYN,HERPUD1,ICAM1,IRS2,ITGA6,LEF1,MAGI1,MAT2A,MET,MYCN,MYO10,MYO1D,MYO5A,NDN,NFIL3,NPHP1,NR4A2,NRCAM,PLAT,PLEK,PLPP3,PRDM1,PRKCI,PSTPIP2,PTPN4,PTPN6,RAB2A,RAB7A,RAPH1,RASA2,RCAN2,RHOA,RHOBTB1,RPL22,RPS11,SNAI1,SNCA,SPARC,SPP1,TGFB1I1,THBS1,TMEM263,TMPRSS2,Tpm1,TWIST1,UTRN,VIM,VWF,WIPF1,WNT11,WNT2,WNT2B,ZBTB16 | 1412 (17) |
| BGN | -1.39e+00 | other | Inhibited | -3.09e+00 | NA | 2.0e-02 | AXIN2,CCND1,CDK2,CXCL13,FBN1,MMP14,PLTP,RUNX2,SERPINE1,UTRN | NA |
| TAC1 | -3.00e-02 | other | Inhibited | -3.09e+00 | NA | 0.0e+00 | CASP1,CASP3,Ccl2,CLEC11A,CUX2,CXCL10,CXCR4,GFAP,HDC,HIF1A,IL17A,IL1RN,KITLG,LDB2,MME,NOS1,PDE1C,PLAT,PTCH1,PTGS2,SELE,SELP,SERPINE1,TGFB1,TNFRSF11B | 1110 (15) |
| ATP | NA | chemical - endogenous mammalian | Inhibited | -3.10e+00 | NA | 0.0e+00 | ACTA2,ADAMTS9,AHR,ARG1,BCL2L11,BDNF,CASP1,Ccl2,CCND1,CCR5,CD200,CD83,CD86,CDH1,CLDN1,CXCL10,CXCR4,DUSP1,ESM1,F3,FLNA,FOXO1,FOXO3,FOXP3,GCLC,HIF1A,HK1,ICAM1,IL1RN,IL2RA,IL33,ITGA4,NLRP3,NOS1,NR4A1,NRP1,PLD2,PTGS2,PYCARD,SERPINE1,SPHK1,SREBF1,THBS1,TLR4,TNFRSF1B,TRPC3,TRPV1,VCAM1 | 1299 (16) |
| S1PR2 | -1.20e+00 | G-protein coupled receptor | Inhibited | -3.10e+00 | NA | 0.0e+00 | ACTA2,Ccl2,F3,ICAM1,PDGFB,PTGS2,S1PR2,SELE,SNAI2,SPHK1,TGFB1,TIMP1,VCAM1 | 775 (14) |
| estrogen | NA | chemical drug | Inhibited | -3.10e+00 | NA | 0.0e+00 | ABCA1,ART3,AXL,BARD1,BCL3,BDNF,BOP1,CALB1,CCND1,CCNE2,CDKN1A,COL14A1,COL18A1,COL1A1,COL3A1,COL5A1,CXCL12,CYBB,DUSP1,EGF,EGR1,ERBB3,ESPL1,FBLN1,FEN1,FN1,G6PD,GAP43,GJB2,GRIN2D,HGF,HIF1A,HIVEP3,ICAM1,IGF1,IGFBP4,IGFBP5,IGFBP6,IL1RL1,IRS1,ITGA5,ITM2A,KDR,LGALS1,LPL,MCM7,MEOX2,MVD,MYBL1,NFIL3,NOS1,NR4A1,NTS,OXTR,PDLIM7,PENK,PLAT,PLIN4,PTAFR,PTGIS,PTGS2,PTX3,RAB11B,RARA,RET,SCX,SERPINB9,SFTPB,SKP2,SMC2,SPARC,SPP1,STAT1,TGFA,TNFRSF11B,TOP2A,TYMS,UHRF1,ZFP36 | 1645 (19) |
| FN1 | -7.10e-01 | enzyme | Inhibited | -3.12e+00 | NA | 0.0e+00 | ACP5,ACTA2,ACTN4,BCAT1,BIRC3,CALCR,CCND1,CCNI,CD83,CDH1,CDH2,CDK6,CDKN1A,CLIC4,COL1A1,CORO1A,CRP,DPF2,EPB41L1,F3,FGF2,FLNA,FN1,GSK3A,HK1,IL1R1,IL7,IRS1,ITGA1,ITGA4,ITGA5,ITGAE,ITGB3,JUND,KCNH2,KIF21B,LIMS1,MAT2A,MAX,MMP14,MMP2,NFKBIA,PDGFB,PDGFRA,PREB,PSMC1,RASSF2,RBBP4,RDX,RECK,RUNX2,SCRN1,SDC1,SDC4,SERPINE1,SKP2,SLC2A1,SLC9A1,SNAI1,SNAI2,SOCS3,SPARC,SPP1,TAGLN,TGFB1,THBS1,TLR2,TNFAIP2,VAV2,VIM | 1622 (18) |
| CD40LG | 4.00e-02 | cytokine | Inhibited | -3.12e+00 | NA | 0.0e+00 | ADAM17,AHR,ALCAM,ALG3,ARSB,ATF3,AUH,AXL,B2M,BATF,BCAT2,BCL2A1,BCL2L1,BCL6,BIRC3,BTG1,BTG3,CASP1,CCR1,CCR5,CD1D,CD44,CD83,CD86,CDC25B,CDK5R1,CDK6,CDKN1A,CELF2,CIITA,CSF1,CSF2RA,CTSC,CXCL10,CXCR4,CYP1B1,CYTIP,DAPP1,DUSP1,DUSP5,E2F2,EGR1,F3,FCGR2B,FSCN1,G0S2,GADD45A,GCH1,GPR183,GZMB,HIF1A,HLA-DQA1,HSP90AA1,HSPA1A/HSPA1B,ICAM1,ID2,IFI44,IFIT1,IL10RA,IL2RA,IL2RB,INHBA,IRF1,IRF4,ISG15,ITGA4,ITGB2,ITGB7,JUND,LMAN2,MAPK4,MARCKSL1,MMP14,MX1,NET1,NFKBIA,NFKBIB,NINJ1,NR4A3,PAWR,PLEK,POLA1,PRDM1,PRKDC,PRR3,PTGS2,PTPN12,PTPN7,RASSF2,REL,RGS2,RIDA,RNF5,SAMSN1,SELE,SELP,SERPINE1,SLAMF1,SOCS1,STAT1,SWAP70,SYMPK,TNFAIP2,TNFAIP6,TNFRSF11B,TNFSF8,TPD52L2,TRADD,TRAF5,TUBB,VCAM1,WNT5A,ZFP36L1 | 1287 (16) |
| CYP2E1 | -6.30e-01 | enzyme | Inhibited | -3.12e+00 | NA | 0.0e+00 | C3AR1,C5AR1,Ccl2,FGL2,GCLC,MGST1,NCF1,NCF2,PTGS2,TLR4 | 1245 (19) |
| CD36 | -6.60e-01 | transmembrane receptor | Inhibited | -3.12e+00 | NA | 1.0e-02 | ADGRE1,ADIPOQ,ARG1,ATP2A2,AXL,Ccl2,CD86,COL1A1,EIF2AK3,FABP1,FGF2,ICAM1,IGFBP4,IGFBP6,IGFBP7,LPL,MMP14,NLRP3,PDGFB,PNPLA2,PPARG,SELP,SERPINE1,SYK,TGFA,TNFRSF10A,TNFRSF11B | NA |
| TEAD2 | -6.40e-01 | transcription regulator | Inhibited | -3.13e+00 | bias | 0.0e+00 | AK5,ARID5B,CCND1,COL3A1,COL5A2,EDN1,FIBIN,IGFBP5,KAZN,LIMCH1,LOXL1,NRXN2,NUAK1,PCDH18,PDGFRL,POLA1,PTPRO,RHOBTB1,SAMD5,SDC2,SH3D19,TAGLN,THBS1,TLE1,TNNT2,TP63,UHRF1 | 603 (7) |
| PCYT1A | 3.40e-01 | enzyme | Inhibited | -3.13e+00 | NA | 0.0e+00 | ABCA1,AXL,Ccl2,CDK18,FGFR1,FRK,GFRA1,KLF4,SIX4,STX3 | 780 (12) |
| CASP3 | -9.60e-01 | peptidase | Inhibited | -3.14e+00 | NA | 2.0e-02 | BCL2L1,CASP3,CDK2,CDKN1A,CTSK,IL16,mir-143,MYOD1,MYOG,RUNX2 | NA |
| IL4R | -2.30e-01 | transmembrane receptor | Inhibited | -3.14e+00 | NA | 2.0e-02 | ACSL1,ALOX15,ARG1,ASIC2,CACNB2,Ccl2,CD86,CTTNBP2,CX3CR1,EGR2,ETV5,FCER1G,FLRT2,GCSAM,HOMER1,IL17A,IL2RA,NGEF,NRXN2,PPARG,PTN,RUNX2,SLC8A3,SOCS3,ZDHHC2 | NA |
| TLR7 | -8.70e-01 | transmembrane receptor | Inhibited | -3.15e+00 | bias | 0.0e+00 | Abi3bp,ACTC1,ATF3,BANK1,BCL2A1,Ccl2,Ccl7,CCND1,CD1D,CD44,CD83,CD86,CDKN1A,CFH,CREB5,CXCL10,CXCL13,ESM1,ETV5,FCER1G,FCMR,FGF2,GCGR,GNG2,ICAM1,IER3,IFI44,IFI44L,IFIT1,IL10RA,IL1R1,IL4I1,INPP5D,IRF1,ISG15,LHFPL1,MOG,MUSK,MX1,NCF4,NFKBIA,OAS3,PLAT,PTCHD1,PTPN6,PTX3,RGS4,RP1,RSAD2,SELE,SOCS1,SPRY4,STAT1,TLR7,TRPM2 | 963 (17) |
| MESP2 | -6.10e-01 | transcription regulator | Inhibited | -3.16e+00 | bias | 0.0e+00 | FOXC1,FOXC2,GATA4,MYOCD,PAX3,SNAI1,SNAI2,TWIST1,TWIST2,ZEB2 | NA |
| GABARAP | 3.40e-01 | transporter | Inhibited | -3.16e+00 | bias | 1.0e-02 | AHNAK2,ARSG,BLVRB,CRYAB,CSPG4,CSTB,CXCR4,GSR,NR1D2,PDGFB,TRPV1 | NA |
| MAP3K12 | 7.00e-02 | kinase | Inhibited | -3.16e+00 | NA | 2.0e-02 | ACTG1,CASP3,CRP,RPL37A,RPS18,RPS2,STMN1,STMN4,TUBA1A,TUBB | NA |
| GABARAPL2 | -2.20e-01 | other | Inhibited | -3.16e+00 | bias | 2.0e-02 | AHNAK2,ARSG,BLVRB,CRYAB,CSPG4,CSTB,CXCR4,GSR,NR1D2,PDGFB | NA |
| GABARAPL1 | 1.65e+00 | other | Inhibited | -3.16e+00 | bias | 2.0e-02 | AHNAK2,ARSG,BLVRB,CRYAB,CSPG4,CSTB,CXCR4,GSR,NR1D2,PDGFB | NA |
| MEF2A | 4.00e-02 | transcription regulator | Inhibited | -3.17e+00 | NA | 0.0e+00 | ACTA1,ACTC1,AQP4,ATP2A2,BDNF,CKM,CLIC6,CXCL10,EDN1,ENO3,FGF16,GATA4,GBP2,Gsta4,IFI44,Ifi47,IRF1,MEOX2,MYH6,MYOCD,NR4A1,Oasl2,RSAD2,STAR,TGFB1,THBD,TNNC1,ZEB2 | 1159 (16) |
| RETNLB | NA | other | Inhibited | -3.17e+00 | bias | 0.0e+00 | ACTA2,BMP1,CASP3,Ccl2,CCR1,CCR5,CD86,COL1A1,CTSE,E2F7,ELN,FABP1,FAP,FGFR1,FN1,FRZB,FZD1,FZD6,IGF1,IRS1,IRS2,KLF15,MAP3K6,MID1,MMP2,MSN,MYCT1,NDN,NR4A1,PLA1A,SFRP1,TGFB1,THBS4,TIMP1,TINAGL1,Tlr13,TLR2,TNNC1,WNT5A | 1048 (14) |
| phenacetin | NA | chemical drug | Inhibited | -3.17e+00 | NA | 0.0e+00 | A2M,A3GALT2,ANXA1,ANXA2,BIRC3,CD44,CP,FBLIM1,GCGR,IER3,LAMC2,MRC1,PLA1A,S100A10,S100A11,SPP1,TES,TIMP1,TMSB10/TMSB4X,TSPAN8,VIM | 900 (7) |
| SOX9 | -1.60e-01 | transcription regulator | Inhibited | -3.18e+00 | NA | 0.0e+00 | ADAMTS1,ADAMTS10,ALDH1A1,BEST1,CDH2,CDKN1A,CNMD,COL1A1,COL2A1,COL3A1,COL5A1,CXCR4,CYP26B1,DMBT1,FGF1,FN1,FOXC1,FZD2,GAS7,GDF10,HIVEP3,IL17A,INHBB,KIT,KLF4,LBP,MAPK3,MIA,MITF,MMP15,NFATC4,NR5A1,OSR2,PAQR6,PPARG,RUNX2,S100A4,SDK2,SMPD3,SNAI2,SOSTDC1,SOX10,SOX8,SULF2,TGFB1,THBS2,TSPAN8,TWIST2,UCP3,WNT11 | 1640 (27) |
| tributyrin | NA | chemical drug | Inhibited | -3.18e+00 | bias | 0.0e+00 | ADRB2,AKAP12,ATF3,BCL2A1,BIRC3,CASP3,CDKN1A,CLDN1,CSGALNACT2,CXCR4,DAPP1,DUSP1,EDN1,ETS1,HDAC4,ID2,INHBA,MME,MYBL1,OCLN,OLR1,PTGS2,RGS4,UGCG | 1118 (17) |
| WNT1 | NA | cytokine | Inhibited | -3.18e+00 | NA | 0.0e+00 | ACTA2,APCDD1,AXIN2,BMP4,CCDC80,CCND1,CCND2,CDH1,CDKN1A,COL3A1,DDIT4L,DLL1,DNAJC1,EDN1,EEF1A1,EGR1,EIF3C,EIF4EBP1,EIF5B,FN1,FZD2,GADD45G,IGF1,ISLR,KIT,KLF5,KRT19,LBH,LEF1,LMX1A,MRAS,MUSK,MYF5,NOTCH4,PITX2,PPARG,PTGS2,RARG,RELN,RUNX2,SEMA3C,SERPINE1,SIM1,SNAI1,SPP1,STRA6,Tcf7,TLE1,TWIST1,VEGFC | 1410 (17) |
| TCOF1 | 6.50e-01 | transcription regulator | Inhibited | -3.18e+00 | bias | 0.0e+00 | ADAMTS1,AK4,ALDH1A1,AMHR2,ANKRD10,ANXA2,COL8A1,EPB41L1,GCNT1,GRHPR,IGFBP5,IQGAP1,JAZF1,KANSL2,KCNS3,KIF26B,KIT,MAPK14,MBOAT2,MEOX1,PDRG1,PLEKHA5,QRICH1,SAFB2,SH3BGRL,SLC2A1,SOSTDC1,TMEM255A,TULP4,UBA3,WWC2 | NA |
| RET | -8.90e-01 | kinase | Inhibited | -3.19e+00 | NA | 0.0e+00 | ACTA1,ACTC1,ANXA1,AUH,CALB1,Ccl2,CCND1,COL1A1,CRYAB,CSF1,CXCL12,CXCR4,DCN,DNAJA1,DPYSL2,DUSP6,EDN3,EDNRB,EGR1,ELN,ETV1,GFRA1,HOPX,HSP90AA1,HSPA1A/HSPA1B,ITGA6,LOX,MAF,MEOX2,MET,MMP14,MYH6,NOS1,PER3,PLOD2,PRKCD,PTN,REEP6,RET,SCARA3,SYMPK,TACC3,TAGLN2,TBX5,TNC,TNNI1,TNNT2,UBQLN2,UNC45B,WNT11 | 1355 (18) |
| IGFBP2 | 5.20e-01 | other | Inhibited | -3.19e+00 | NA | 0.0e+00 | BCL2L1,CASP3,CCND1,CDH1,COL11A1,COL14A1,DDAH1,EMP2,EPHA4,ESCO2,FN1,IGFBP4,ITGA5,ITGA6,LGR5,MMP2,NEDD9,NUP210,PTGFRN,PTN,PTPRB,THBS2 | 1451 (17) |
| MET | 1.91e+00 | kinase | Inhibited | -3.20e+00 | NA | 0.0e+00 | ARID5A,BMP1,Ccl7,CCND1,CCND2,CD44,CDH1,CDH2,CDKN1A,CITED2,CLDN1,COL5A2,DAB2,E2F5,EDN1,FBXO32,FGL2,FN1,GCLC,HDC,HGF,HLX,IGF1,IL15RA,INHBA,ITGA3,KLF4,LAMA3,LEF1,MAD1L1,MAL,MMP2,MPP7,MYOD1,MYOG,NOTCH4,NOX4,PIM3,PLK1,PLK2,PTGS2,RILPL1,RUNX1,SLA,SLCO3A1,SNAI1,SOCS3,SPP1,TGFA,TGFB1,TNFSF8,TRIM63,VEGFC,VIM,ZEB2 | 931 (13) |
| MYOC | -5.30e-01 | other | Inhibited | -3.20e+00 | NA | 0.0e+00 | ADAMTS1,ANXA1,CD44,CDH11,CHRDL1,CNKSR2,CNP,DAB2,DDIT4,EGR2,EIF2AK3,ENPEP,FBN1,FBXO32,FN1,FSCN1,GPRASP1,IGFBP5,LAMA2,LHX8,MPZ,PLP1,PRKCB,PXDN,RUNX2,S100B,SFRP1,SOSTDC1,SPP1,TCEAL7,TRIM63 | 1429 (23) |
| laminaran | NA | chemical drug | Inhibited | -3.21e+00 | bias | 0.0e+00 | CLDN1,CXCL10,ELOVL7,G0S2,GCH1,IFI44L,IL2RA,INHBA,OLR1,PTGS2,RSAD2,SLC39A8,TNC,TNFAIP6 | 514 (7) |
| SOX10 | -1.93e+00 | transcription regulator | Inhibited | -3.23e+00 | NA | 0.0e+00 | ACKR3,CDH2,CDKN1A,DEPDC1B,DHH,EDNRB,EGR2,ERBB3,FN1,GAS7,GDA,GZMB,IRF1,IRF4,ITGA6,L1CAM,MAG,MITF,MPZ,MYRF,PAX3,PLP1,PMP22,PTN,RET,SOX10 | 962 (8) |
| D-galactosamine | NA | chemical - endogenous mammalian | Inhibited | -3.24e+00 | NA | 1.0e-02 | BTK,CASP1,CASP8,CXCL10,ICAM1,IL33,JUND,NFE2L2,NFKBIA,NLRP3,PTGS2,PTN,TIMP1,TLR4,TRADD | NA |
| STX18 | 4.10e-01 | transporter | Inhibited | -3.24e+00 | bias | 0.0e+00 | ANPEP,ARHGAP29,BCL3,BMP1,BUB1,CEP131,COL5A1,COL7A1,CSNK1D,DPYSL3,ERCC1,EZH2,FBLN1,FBN2,HNRNPU,HUS1,ID2,IGFBP4,LAMC2,LOXL2,NCK2,PALLD,PMEPA1,POLA2,POLE4,POLR2J,RBL1,RFC5,SDC1,SERPINE1,SFRP1,SLC7A1,SLIT3,TAGLN,TGFB1,TGFBI,TNC,TOP2A | NA |
| BMP2 | -3.30e-01 | growth factor | Inhibited | -3.27e+00 | NA | 0.0e+00 | ACP5,ACTA2,BCL2L1,BDNF,BHLHE40,BMP4,BTG3,CALB1,Cald1,CCND1,CDH1,CDKN1A,CLDN3,CLIC4,COL1A1,COL2A1,CREB3L1,CRYM,CSF1,CTSK,CXCL12,DMP1,DPYSL2,EGF,ERCC1,ESRRG,ETS1,EVC2,F3,FGF2,FGFR1,FN1,FOXO1,FOXP3,FZD1,GADD45B,GFAP,GFRA1,GREM1,HAS2,ID2,ID4,IFI16,IGFBP5,INHBA,KLF10,KLF4,KLF9,L1CAM,MC2R,MMP2,MRAS,MYOG,NFAT5,NFYA,PITX2,PPARG,PTGS2,PTX3,RET,RGS6,RUNX2,SMAD6,SMAD7,SOSTDC1,SOX6,SPARC,SPP1,STAR,TAGLN,TIMP1,TMEM119,TNFRSF11B,TNNT1,VCAN,WNT4,ZBTB16 | 1544 (21) |
| NFATC1 | 4.80e-01 | transcription regulator | Inhibited | -3.28e+00 | NA | 0.0e+00 | ACP5,AHR,ATF3,CALCR,CCND1,CCND2,COL1A1,CTSK,CX3CR1,CXCR5,CYBB,CYP1B1,EDN1,EGR3,FKBP11,FOXP3,GLI1,ICAM1,IL17A,IL2RA,IL33,ITGB3,KCNJ11,MAFA,MYH7,NFATC3,NOX4,PDIA4,PLS3,PPARG,PRDM1,PTGS2,SLAMF1,SPP1,THBS1,UTRN,VCAM1 | 1284 (16) |
| ERK | NA | group | Inhibited | -3.28e+00 | NA | 0.0e+00 | ABCA1,ACP5,ACSL5,ACTA2,ADAM10,ADGRG6,AXL,BCL2L1,BCL2L11,BGN,BTG2,BTG3,CAV1,Ccl2,Ccl7,CCND1,CCR1,CD1D,CDH1,CDK5R1,CDKN1A,CEBPD,COL1A1,COL3A1,CTSK,CXCL10,DPYSL2,DUSP1,EDN1,EGR1,EGR2,ETS1,EZH2,FGF2,FN1,FOXO1,FOXO3,FOXP3,GCLC,GPRC5C,HAS3,HEY2,HOMER1,ICAM1,IER3,IL17A,IRS1,ITGA2B,ITGB2,ITGB3,JAG1,KLF10,KLF5,MAFF,MAL,MMP14,MMP2,NFE2L2,PDGFC,PDK4,PPARD,PRDM1,PTGES,PTGS2,RAB7B,RECK,RGS4,ROCK1,RUNX2,SERPINE1,SFTPB,SLC2A1,SNAI2,SORT1,STAT1,STMN4,TGFA,THBS1,TIMP1,TNFAIP8,TRPC3,TUBA1A,UGCG,VCAN,VTCN1,ZFP36,ZFP36L1 | 1443 (17) |
| FZD9 | -6.50e-01 | G-protein coupled receptor | Inhibited | -3.28e+00 | bias | 0.0e+00 | Ccl2,CDH1,CDH2,CXCL10,CXCL14,IFI16,IFI44,ISG15,Oasl2,SPRY4,STAT1 | 1345 (17) |
| RARB | -1.00e-02 | ligand-dependent nuclear receptor | Inhibited | -3.29e+00 | NA | 0.0e+00 | ADAM10,ARHGAP4,ATP6V0A4,BCL2A1,CDKN1A,CRYAB,CXCL12,CYP26B1,EGR1,ENOX1,ETS1,EZR,FOLR2,GADD45A,GAP43,GATA4,GBP2,HOXA5,ICAM1,Ifi47,IFIT1,IGFBP6,IL17A,KLF4,Naip1 (includes others),NR2F1,NTN1,PITX2,PTGER3,PTGS2,RARA,RET,SALL4,SLC16A2,SLC26A3,SLC2A1,SPP1,STAT1,STAT6,STRA6,TGFB1,THBD,UBA7,USP18,VEGFC | 1456 (21) |
| sphingosine-1-phosphate | NA | chemical - endogenous mammalian | Inhibited | -3.29e+00 | NA | 0.0e+00 | ACER2,ACKR4,ACTA2,AHR,ALDH1A3,ANXA2,BDKRB2,BTRC,Ccl2,CCND1,CCR3,CD276,CD36,CD44,CD83,CDH1,COL3A1,CSF2RB,CXCL10,EGR1,ETS1,FAM167A,FGF2,FN1,GAP43,GBP5,HAS2,HIF1A,ICAM1,ID2,IGF1,IRF6,ITGB2,KCNH2,KDR,KLF5,MEOX1,MMP14,NCAM1,NCKAP1L,NFE2L2,NRP1,NRP2,NSG2,NUP210,PDGFB,PIEZO2,PLA2G2A,PLA2G2D,PPARGC1B,PTGS2,RARA,RUNX2,RXRA,S1PR2,SELE,SERPINE1,SNAI2,SORCS2,SPHK1,ST8SIA2,STAR,TAGLN,TGFB1,THBS1,TIMP1,TNFRSF11B,VCAM1,VEGFC,VIM,VWF,WNT11 | 1190 (15) |
| CCL5 | 5.30e-01 | cytokine | Inhibited | -3.30e+00 | NA | 0.0e+00 | ADGRE5,AHR,AIF1,ALCAM,BDNF,C5AR1,Ccl2,CCR1,CCR3,CCR5,CCRL2,CD44,CYP1B1,DDAH1,DUSP1,DUSP6,EGF,EMP1,F2R,F2RL1,GFAP,HDC,LIMS1,MAPK3,MMP19,NCOR2,OLR1,SGK1,STAT1,THBS1,TLR4,ZFP36 | 1398 (16) |
| FGF7 | -1.80e-01 | growth factor | Inhibited | -3.30e+00 | NA | 0.0e+00 | ABCC3,ACTA2,BCL2L1,CCND1,CD44,CDK2,CDKN1A,CEBPD,COL1A1,CSF1,ETV5,FGF1,FGFR1,HAS2,HAS3,IL7,IRF1,Krt10,LPCAT1,MMP2,NFE2L2,PTAFR,RUNX2,S100A10,SDC1,SERPINE1,SFTPB,SREBF1,STAT1,TGFB1 | 878 (15) |
| TLR4 | -1.90e+00 | transmembrane receptor | Inhibited | -3.30e+00 | NA | 0.0e+00 | ACTA1,ADORA2A,ALDOA,ARG1,ARID5A,ATF3,BAMBI,BATF,BCL2L1,C3,CASP8,Ccl2,Ccl7,CCND2,CCR5,CCRL2,CD200,CD200R1,CD44,CD86,CDH1,CDK6,CEBPD,CERS6,CFB,CISH,CITED2,CMA1,COX4I1,CTSK,CXCL10,DAB2,DLK1,DOCK11,DUOX2,E2F5,EDN1,EGF,F3,FBXO32,FCGR2B,FGL2,FLT3LG,GADD45G,GBP2,GFAP,GPR34,HDC,HHEX,HLA-DQA1,HNRNPU,HPSE,ICAM1,IFI16,Ifi47,IFITM3,IL15RA,IL17A,IL18BP,IL2RA,IL2RB,INHBA,IRAK3,IRF1,IRF3,IRF8,ISG15,JAG1,LYST,MET,MX1,MYH7,NFKBIA,NLRP3,NMI,NOD2,NOS1,NR4A1,NR4A2,NR4A3,OASL,OXTR,PDPN,PKM,PLA1A,PLA2G4A,PLAGL1,PLAT,PLEK,PLK2,PPARG,PRDM1,PROX1,PTGES,PTGFR,PTGS2,PTX3,RBL1,REL,RGCC,RGS14,RGS18,RILPL1,RIPK2,RSAD2,RUNX1,RXRA,SAP30,SELE,SELP,SIGIRR,SLA,SLC2A1,SLCO3A1,SMPDL3B,SOCS1,SOCS3,SPHK1,SPP1,SREBF1,ST3GAL1,STAT1,TGFB1,TLR2,TLR4,TNFAIP8L2,TNFRSF10A,TNFSF8,TRIM63,TSPAN33,UGCG,VCAM1,ZC3H12C | 1569 (15) |
| ERK1/2 | NA | group | Inhibited | -3.31e+00 | NA | 0.0e+00 | ABCA1,ADAM10,ADIPOQ,ALOX5,ANGPT2,ANKRD2,APLN,B2M,BCL2A1,BCL2L1,BCL2L11,BDNF,BIRC3,C3,CAV1,Ccl2,CCND1,CCND2,CD44,CD86,CDC42EP5,CDKN1A,CLEC11A,CMA1,COL1A1,COL2A1,COL3A1,CXCL10,CXCR4,CYBB,DAPK1,DUSP1,EDN1,EGR1,EIF2AK3,EMCN,ETS1,EZR,F3,FGF2,FKBP5,FN1,FOXO1,FZD1,GAD1,GRK5,HAS2,HLA-A,ICAM1,IFIT1,IL17RD,IL2RA,IRS2,ITGA2,ITGA3,ITGB3,JUND,KCNH2,LEPR,MAP2K2,MAP3K10,MAP4K1,MAPK3,mir-133,MMP2,MYCN,MYOCD,MYOG,NOX1,NOX4,NR4A3,PDGFRA,PFKFB4,PKM,PRKCZ,PTGES,PTGS2,PTN,RUNX2,S100A6,SERPINE1,SGK1,SLC12A4,SLC12A7,SNAI1,SNAI2,SOCS3,SPP1,SPRY4,STAR,TIMP1,TRIM63,VCAM1,VCAN | 1516 (18) |
| HMGXB4 | -5.50e-01 | other | Inhibited | -3.32e+00 | bias | 0.0e+00 | CSRP1,DSE,ICAM1,IER5,IFIH1,IQGAP1,KLF6,MOB1A,PARP14,RNF213,TNFAIP2 | NA |
| CpG ODN 2006 | NA | chemical reagent | Inhibited | -3.32e+00 | NA | 0.0e+00 | ACTG1,BATF,BCL2A1,BCL2L1,BIRC3,CASP8,CCND2,CD22,CD226,CD86,CSK,CXCL10,DLL1,DOCK10,EPSTI1,EZR,FEZ1,GBP4,GBP5,GPR160,GPR183,GRAP,GRHPR,GZMB,HCK,HDAC9,HHEX,HSP90AA1,ICAM1,IFI44,IFI44L,IFIH1,IFIT1,IL15RA,IL17A,IL2RA,IL2RB,IL7,IRS2,KHDRBS1,LAT2,LGALS1,LYN,MX1,MYO1G,NCKAP1L,NFAM1,NOD2,NOTCH2,OASL,PDE4D,PRKCB,PRKCE,PRKDC,PSMA4,PSMA6,PSMB1,PSMB5,PSMC1,PSMC5,PSMD13,PTPN6,RGCC,RSAD2,RUNX1,STAT1,STOML2,TGFB1,THEMIS2,TLR10,TLR4,TLR5,TLR7,TNFAIP6,TNFSF18,USP18,VCAM1,VOPP1,ZFP36L1,ZFP36L2 | 751 (15) |
| ETS1 | -9.70e-01 | transcription regulator | Inhibited | -3.33e+00 | NA | 0.0e+00 | ANPEP,ARHGDIB,BCL11A,BCL2L1,BMP4,BTRC,CASP1,CAV1,Ccl2,CCND1,CD44,CDH1,CDH2,CDK11A,CDK2,CDK6,CDKN1A,CITED2,COL2A1,CSF1R,CX3CL1,EEF1D,EGR1,ETS1,FLI1,FN1,FOXP3,GSK3A,HGF,HPSE,HSPA1A/HSPA1B,HSPE1,ICAM1,ID2,IKZF2,IL17A,IL2RA,IL2RB,ITGA10,ITGA2B,ITGAE,ITGB2,ITGB3,MET,MMP2,MSR1,NCF1,NFIL3,NPR1,PRDM1,RUNX1,RUNX2,SERPINE1,SNAI1,SNAI2,SPP1,TBXAS1,TGFA,THY1,TWIST1,TYMS,VIM,ZEB2 | 1561 (22) |
| TRAF3IP2 | -2.30e-01 | enzyme | Inhibited | -3.34e+00 | NA | 0.0e+00 | Ccl2,CCL21,CCL24,Ccl7,CCR3,CDH3,CEBPD,COL1A1,COL3A1,CSF1,CX3CL1,CXCL10,CXCL16,FGF2,ICAM1,IL17A,IL33,ISG15,ITGAL,MMP2,SELP,TGFB1,TP63,VCAM1 | 1225 (12) |
| lysophosphatidic acid | NA | chemical - other | Inhibited | -3.35e+00 | NA | 0.0e+00 | ACTA2,ANKRD1,BCL6,Ccl2,CCND1,CD36,CSF1,CXCL10,DUSP1,EDN1,EGR1,F3,FKBP5,HIF1A,ICAM1,KDR,KLF5,LIPG,LPL,MAG,MPZ,MSR1,PDGFRA,PFKFB1,PPARG,PPP1R3B,PTGS2,SERPINE1,SLC26A3,SNAI1,SOCS1,SPHK1,TAGLN,VCAM1,VEGFC,VIM,WNT5A | 1345 (15) |
| LEP | -3.80e-01 | growth factor | Inhibited | -3.35e+00 | NA | 0.0e+00 | ABCC3,ACADL,ACSL3,ACSL5,ACTA2,ADGRE1,ADIPOQ,ALDOA,ANGPT2,AQP7,ATP2A2,AXIN2,BCL2A1,BCL2L1,BDNF,BMP4,CA3,CASP1,CASP3,CAV1,Ccl2,CCNA2,CCND1,CD36,CDH1,CDKN1A,CNN1,COL1A1,COL2A1,COL3A1,COL6A3,CRHR2,CRP,CUX1,CXCL10,CYBA,CYBB,DLK1,DUSP6,ECH1,EDN1,EGR1,EGR2,ELOVL5,F3,FAAH,FADD,FADS2,FBP2,FGFR1,FN1,FOXO3,FOXP3,GADD45A,GAP43,GAPDH,GCLC,GFAP,GNAS,GPAM,HEY2,HIF1A,HK1,ICAM1,IDH1,IFT27,IGF1,IL1R1,IL1RN,IRF1,IRS1,IRS2,JAG1,JUND,KDR,KHDRBS1,LEPR,LPL,MAP1LC3B,mir-143,MMP14,MMP19,MMP2,MSI1,MSMO1,MYH7,MYOD1,MYOG,NCF1,NCF2,NLRP3,NOS1,NOTCH2,NOTCH4,NPR1,NPR2,NTS,Pcsk1,PLAT,PLIN1,PLP1,PNPLA2,PPARG,PPARGC1B,PRDM16,PRDX1,PRKAA2,PRKAB2,PTGS2,RETN,RFX1,RUNX2,Scd2,SELE,SELENOP,SELP,SERPINE1,SIM1,SLC16A1,SLC27A1,SOCS3,SORD,SPARC,SPP1,SREBF1,STAR,TAGLN,TGFB1,THBS1,TIMP1,TNFRSF11B,TRPV1,UCN2,UCP3,VCAM1,VIM,WNT5A,ZFP36 | 1763 (22) |
| E2f | NA | group | Inhibited | -3.36e+00 | NA | 1.4e-01 | Bmyc,CAV1,CCNA2,CDK2,CSDE1,DUOX2,E2F2,E2F8,EFHC1,HIF1A,IGF1,ITGA5,ITGA6,ITGB4,KNTC1,MYCN,PCSK1N,PFKFB1,PGRMC1,POLA1,POLA2,RBL1,RPS16,SERPINE1,STMN1,TYMS | NA |
| N-ethyl-N-nitrosourea | NA | chemical toxicant | Inhibited | -3.36e+00 | bias | 1.0e-02 | CCL24,CDKN1A,CRP,CSF1,CX3CL1,CXCL13,HSP90AA1,ICAM1,IFI44,IFIH1,IFITM3,IL17A,ISG15,Mt1,Oasl2,SPP1,TIMP1,TNFRSF1B,TNFSF8 | NA |
| concanavalin a | NA | chemical drug | Inhibited | -3.36e+00 | NA | 0.0e+00 | BCL2A1,BCL2L1,BCL2L11,CASP1,CASP3,Ccl2,CD86,CDKN1A,CXCL10,EGR1,EGR3,FOXO1,HIF1A,HTR1B,HTR2A,HTR7,ICAM1,IL17A,IL18BP,IL1RN,IL2RA,IRF1,IRF4,ITGB2,KHK,LAMP2,LGALS1,MET,MMP14,NFAT5,NPR1,NR0B2,PENK,PRDM1,PTGS2,PTPN7,RGS2,SDC4,SIPA1,SLC37A4,SOCS3,SPP1,STAT1,TGFB1 | 1279 (18) |
| SHH | -6.20e-01 | peptidase | Inhibited | -3.37e+00 | NA | 0.0e+00 | ADAMTS1,AMD1,ANGPT2,BCAR1,BMP4,CAV1,CCND1,CCND2,CD93,CDH1,CSF1,CSF1R,DAAM1,DTX1,EBF1,EIF2AK3,EPHB4,FGF10,FN1,FOXC2,GATA4,GLI1,GLI2,HEY2,HGF,HIF1A,IGF1,IGFBP5,IL2RA,LASP1,LMX1A,MAGI1,MET,MYCN,MYF5,MYOD1,NOX4,NR2F2,NR4A1,OCLN,PAX3,PDGFRA,PFN1,PITX2,PLAT,PMP22,PPARG,PTCH1,RUNX2,SERPINE1,SFRP1,SFRP2,SNAI2,SOSTDC1,SPP1,SREBF1,THBD,TYMS,WNT5A | 1513 (20) |
| RAF1 | 1.40e-01 | kinase | Inhibited | -3.38e+00 | NA | 0.0e+00 | ACOT7,AKAP12,AMD1,ANKRD1,ANKRD2,ANXA1,BCL2L11,BCL6,BTG1,CCND1,CD37,CD44,CD74,CDKN1A,CDON,CLDN1,CLK1,CRP,CRYAB,CSTF1,CTSH,CXCR5,DUSP5,DUSP6,EGR1,EGR3,EMCN,EMP1,EMP3,FAM171A1,HDC,HIF1A,IER3,IL1R1,ITGA2,ITGB3,ITGB4,LAD1,LAMA3,MAOB,MCM8,MET,MKI67,NINJ1,OCLN,OPCML,OSMR,PC,PHLDA1,PLAT,PLD1,PRDM1,PTGS2,RET,RND3,RPS2,SDC1,SEC14L2,SELENBP1,SLC16A7,TCOF1,TFPI2,TIMP1,TNNI1,Tpm1,Tpm3,ZFP36L2 | 1200 (18) |
| peptidoglycan | NA | chemical - endogenous non-mammalian | Inhibited | -3.38e+00 | NA | 1.0e-02 | BCL2A1,CASP3,Ccl2,CCR5,CD200,CD86,CORO1A,CXCL10,CXCL16,CXCR4,DUSP1,EGR1,FOXP3,ICAM1,IL16,IL17A,IL1RN,IL2RA,IRF1,ITGB2,NLRP3,PTGS2,Tlr13,TLR2,TLR4,TLR5,TLR7,TMSB10/TMSB4X | NA |
| SRC (family) | NA | group | Inhibited | -3.38e+00 | NA | 0.0e+00 | ATP1A1,Ccl2,CD36,CDH2,EGR1,FGF2,FGR,FN1,HIF1A,ICAM1,ITGB3,NOX1,PROM1,PTGS2,S100A4,SNAI1,STAT1,VCAM1,VEGFC | 1281 (15) |
| ARNT2 | -1.32e+00 | transcription regulator | Inhibited | -3.40e+00 | bias | 0.0e+00 | ABCG1,ABI1,ANGPT2,AOX1,AQP4,AQP7,ARNT2,CACNG1,CAMLG,CBFB,CCR1,CCS,CD86,CDH3,CELF2,CFL2,CMKLR1,COL11A1,COL12A1,CPXM2,CXCR5,CYBA,DLL1,EGF,EGR1,ELL2,EYA1,GLI1,GLUL,GPX3,HLA-A,HOMER1,ICAM1,IFI16,IGFBP4,ITGB3,KCNJ15,LAMA2,LCAT,LCP1,LDB2,LHX8,MCM7,MYH6,MYH7,NDUFA1,NGEF,NR5A1,NUDC,OAZ1,PDLIM4,PEA15,PFN1,PGK1,PKIB,PLA2G5,PLCB1,PLP1,PMFBP1,RGS10,SELENBP1,SIM1,SLC2A1,SOX10,Sp100,SRSF1,TXNRD3,ZFP36L1 | NA |
| D-fructose | NA | chemical - endogenous mammalian | Inhibited | -3.40e+00 | NA | 0.0e+00 | ACTA2,ADIPOQ,Ccl2,Ccl7,COL1A1,COL3A1,CXCL10,FN1,ICAM1,MMP2,PPARG,SLC26A3,SLC2A5,SLC9A3,SREBF1,TGFB1,THBS1,TIMP1,TKT | 1534 (20) |
| JAK1/2 | NA | group | Inhibited | -3.40e+00 | bias | 0.0e+00 | BAIAP2,BCL11B,BHLHE22,CA12,Ccl2,CD74,CIITA,DGKG,FAM107A,GBP2,GBP5,GDA,HLA-DQA1,HLA-DRA,Ifgga2l1/RGD1309362,Ifi47,IRF1,ISG15,KCNF1,MX1,NPTXR,RGS14,RPRML,RSAD2,WIPF3 | 1190 (14) |
| EGR1 | -1.72e+00 | transcription regulator | Inhibited | -3.40e+00 | NA | 0.0e+00 | ACTA2,ATF3,ATP2A2,BAIAP2,BCAR1,BCL2L11,CASP3,CASP8,CAV1,Ccl2,CCL21,Ccl6,Ccl7,CCND1,CCND2,CCR1,CD44,CDH1,CDK5R1,CDKN1A,COL1A1,COL2A1,CREM,CSF1,EGR1,EGR2,EIF4EBP1,ENPEP,EZH2,F3,FGF2,FN1,FOXP3,FTL,FYN,GAD1,GADD45A,GADD45B,GLI1,GNAS,HIF1A,HPSE,ICAM1,JUND,KCNT1,MAOB,MAP1LC3B,MMP14,MYBL1,NAB2,NR4A1,PDGFC,PNMT,PNPLA2,PPARG,PTGES,PTGS2,RRAD,SERPINE1,SGK1,SNAI1,SNAI2,SOCS1,SPP1,TGFB1,THBS1,TIMP1,TLR4,UFSP1,VCAM1,WNT4 | 1579 (19) |
| FOXC1 | -9.20e-01 | transcription regulator | Inhibited | -3.41e+00 | NA | 0.0e+00 | B2M,BCL2L11,COL1A1,COL2A1,CXCR4,DLL1,DMP1,ECM1,FOXO1,GBP4,GPNMB,ICAM1,IFIT1,IFITM3,IRF1,IRF6,ISG15,ITGB3,ITGBL1,KLF5,MID1,MX1,NFATC4,OAS3,OASL,OSR2,OSTN,PITX2,PTAFR,RUNX2,SERPINE1,SNAI2,SOCS3,SOX6,SPP1,STAT1,TCF15,USP18,WNT5A | 624 (8) |
| IL17A | 1.03e+00 | cytokine | Inhibited | -3.42e+00 | NA | 0.0e+00 | ACTA2,APBA3,B2M,BCL2A1,BCL2L1,BCL3,C15orf48,C3,Calm1 (includes others),Ccl2,Ccl7,CCND1,CCR5,CD83,CDH1,CDH2,CEBPD,COL1A1,COL2A1,COL3A1,COTL1,CRP,CTSK,CX3CL1,CXCL10,CXCL12,CXCL13,CXCR4,CYP7B1,DUOX2,EDIL3,EGR2,ENTPD1,FGF2,FN1,GADD45A,GBP2,HGF,ICAM1,IGF1,IL16,IL17A,IL17RA,IL1RN,IL33,IRF1,ISG15,JAG1,KLF3,LOX,LPL,MAPK14,METRNL,MMP2,MRC1,NR4A2,NRP1,NTN1,OCLN,OSMR,PLA2G4E,PLAT,PPARG,PRDM1,PTGFR,PTGS2,S1PR2,SDC2,SELE,SELP,SERPINE1,SGK1,SLC2A1,SLC9A3,SOCS1,SOCS3,SPP1,SREBF1,STAT1,TGFA,TGFB1,THBD,TIMP1,TLR2,TLR4,TNC,TNFRSF11B,TNFRSF1B,TNNC1,TP63,VCAM1,VEGFC,VEGFD,VIM,VWF | 1301 (14) |
| APP | -4.10e-01 | other | Inhibited | -3.43e+00 | NA | 0.0e+00 | ABCA1,ABCA7,ABCG1,ACO2,ACTA1,ACTA2,ACTG1,ACTN2,ADAM10,ADAM19,AIF1,AK1,ALDOA,ANXA5,APBA2,ARG1,ARRDC3,ATOX1,ATP1B1,ATP6V1A,ATP6V1E1,ATRX,AXIN2,AXL,BACE2,BCL2L1,BCL2L11,BDNF,BIN1,BMP4,C1R,C3,CA12,CALB1,CAMK2D,CASP1,Casp12,CASP3,Ccl2,CCL21,Ccl7,CCNA2,CCND1,CCND2,CCR5,CD44,CD74,CD86,CDC14A,CDH1,CDH2,CDH3,CDK2,CDK5R1,CDK6,CDKN1A,CFH,CFL1,CFL2,CITED2,CKMT1A/CKMT1B,CLDN1,CLIC1,CLTB,COL13A1,COL18A1,COX4I1,CP,CPLX1,CPNE6,CRYL1,CRYM,CSF1,CSF1R,CSF2RB,CXCL10,CXCL12,CXCR4,CYBB,CYP26B1,DBN1,DCN,DDAH1,DHCR7,DNAJC5,DNM1,DPY19L3,DPYSL2,ECE2,ECH1,EDN1,EGR1,EIF5A2,ELN,ELOVL4,ENG,ENO2,EPHB2,ERMP1,EXT1,EYA4,F2RL1,F2RL3,FAP,FCGR1A,FCGR2B,FGF2,FGFR1,FLNA,FN1,Fnbp1l,FOXO3,Foxp1,FYN,FZD1,GAB1,GAP43,GAPDH,GBP2,GBP4,GFAP,GNG2,GPI,GSK3A,Gsta4,HAP1,HBA1/HBA2,HCAR2,HDAC4,HEATR5A,HERC6,HERPUD1,HEY2,HGF,HINT1,HIVEP3,HK1,Hnrnpa3,HOMER1,HSP90AA1,HSPA1A/HSPA1B,HSPE1,ICAM1,IFI16,Ifi47,IFIH1,IGF1,IGFBP5,IL17A,IL4I1,IL7,INHBA,IRF1,IRF3,IRF4,IRF5,IRS2,ITGA1,ITGA2,ITGA3,ITGA4,ITGA6,ITGAL,ITGB3,JUND,KCNC4,L1CAM,LBP,LCAT,LDB2,LDHB,LEF1,LHFPL2,LPAR6,MADD,MAF,MAFF,MAGI1,MAP1B,MAP2,MAP2K2,MBD4,MDK,MGAT3,MME,MMP14,MMP2,MRC1,MSR1,Mt1,NCDN,NCF1,NEFL,NLRP3,NOS1,NR4A2,NRP1,NRP2,NSMF,OCLN,OGN,OLR1,P2rx7,PARP14,PAX3,Pcp4l1,PDGFB,PDGFRA,PDK2,PEA15,PEBP1,PENK,PFKFB3,PGK1,PIK3R1,PITX3,PKM,PKP3,PLAT,PLK1,Pmaip1,PPARD,PPARG,PPIA,PRDX5,PRIMA1,PRKCB,PRKDC,PRPF40B,PSENEN,PSIP1,PTGS2,PTPA,PTPRC,PVALB,PYCARD,R3HDM4,RASSF2,RBL1,RELN,RHOA,RNF213,ROCK1,RSAD2,RTP4,RUNX1T1,RUNX2,S100B,SAP30,SCN1A,SDC4,SERPINE1,SERPINF1,SHISA3,SHOX2,SIRPA,SIRT7,SLAMF1,SLC25A38,SLFN13,SMAD7,SNCA,SOCS1,SOCS3,ST6GAL1,ST8SIA4,STAT6,STMN1,SYP,TAGLN,TGFB1,THY1,TLR10,TLR2,TLR4,TLR5,TLR7,TLR8,TNFAIP2,TNFRSF10A,TNFRSF11B,TOP2A,TOR3A,TP63,TPD52L1,Tpm1,TPPP,TUBA1A,TUBA8,TUBB,TUBB6,UBC,USP18,VCAM1,VCAN,VSNL1,WNK1,WNT4,ZFP36L1,ZNRF1 | 1582 (17) |
| ITGA11 | -1.65e+00 | other | Inhibited | -3.43e+00 | bias | 0.0e+00 | ACTA2,COL1A1,COL8A1,FN1,IGF1,MMP14,SPARC,SPP1,TGFB1,THBS1,TIMP1,TNC | 983 (7) |
| vancomycin | NA | biologic drug | Inhibited | -3.43e+00 | NA | 0.0e+00 | A2M,A3GALT2,ABCC3,ABI1,ACTA2,ADAMTS1,AGMO,AK1,ALCAM,ANXA1,ANXA2,APOD,ASNS,BACH1,Bex2/LOC100912195,BIRC3,BMP1,BMP4,C3,CCND1,CCS,CD44,CD9,CITED2,COL3A1,CP,CRYL1,CSF1,DNAJB4,EMP3,EXTL3,FBLIM1,FMO2,GCGR,GPM6A,GPNMB,GPX8,IER3,IGFBP5,IL10RA,IL17A,ITGB4,KHDRBS3,LAMC2,LAMP2,LGALS1,MCOLN1,MMP2,MRC1,NOX4,NUAK1,PLA1A,PRKCD,PTPRZ1,RHOA,RTN4RL1,S100A10,S100A11,SLC37A2,SLC7A8,SLCO4A1,SPP1,ST3GAL6,SYNJ1,TES,TIMP1,TMC7,TMSB10/TMSB4X,Tpm1,TSPAN8,TUBB,VIM | 1318 (22) |
| Collagen type I (complex) | NA | complex | Inhibited | -3.43e+00 | NA | 0.0e+00 | ACTA2,CCND1,CD83,CDH1,CDH2,COL1A1,EIF4EBP1,EXOC3L2,F13A1,FN1,FOXO3,ITGA1,ITGA2,ITGA3,KDR,MMP14,MMP2,PLOD2,PRRX2,PTGS2,RECK,RUNX2,S100A10,SKP2,TGFB1,TNC,VIM | 1410 (23) |
| TRPV4 | -6.70e-01 | ion channel | Inhibited | -3.43e+00 | NA | 1.0e-02 | Ccl2,Ccl7,COL2A1,CXCL10,DUSP1,FN1,RHOA,SOCS3,THBS1,TIMP1,TLR2,VCAM1 | 1208 (19) |
| EIF2AK2 | -1.60e-01 | kinase | Inhibited | -3.43e+00 | NA | 0.0e+00 | ARG1,ATF3,BCL2A1,BCL2L1,BDNF,BHLHE40,CCND1,CDKN1A,CEBPD,EGR1,IFIT1,IRF1,IRS2,ISG15,NEDD9,NFKBIA,NMI,NNMT,OAS3,PARP9,REC8,SELE,SOCS3,SP140,STAT1,TUBA1A,UBE2L6,USP18,ZC3HAV1,ZNF532 | 856 (16) |
| pristane | NA | chemical toxicant | Inhibited | -3.43e+00 | NA | 0.0e+00 | ARG1,Ccl2,CCL21,CD86,CXCL10,FN1,ICAM1,IFI16,IL17A,IRF5,IRF8,ISG15,MRC1,OAS3,Oasl2,PTGS2,TGFB1,VIM | 1058 (15) |
| FOXF1 | -5.50e-01 | transcription regulator | Inhibited | -3.45e+00 | NA | 0.0e+00 | ACTG2,CCND1,CD34,CDH1,CDK2,CDK6,CDKN1A,ERRFI1,FGF2,HGF,ITGA5,ITGB3,KDR,PDGFB,PDGFRA,TEK,VCAM1,WNT5A | NA |
| FGFR1 | -6.30e-01 | kinase | Inhibited | -3.45e+00 | NA | 0.0e+00 | ADAMTS2,ADAMTS5,BMP4,CCND1,CCND2,CDKN1A,COL1A1,COL3A1,DLL1,DNAJC1,EEF1A1,EIF2AK3,EIF3C,EIF4EBP1,EIF5B,ELN,ENG,FGF1,FGF10,FGF2,FGFR1,HAS2,HGF,ITGA1,ITGA10,ITGB4,LOX,MMP14,OLFML2A,PDGFB,PDGFRA,PLP1,POU2F2,PTGS2,SPARC,TGFB1,TGFBI,TNC,VIM | 1340 (17) |
| GLIS1 | 0.00e+00 | transcription regulator | Inhibited | -3.45e+00 | NA | 0.0e+00 | ADAMTS10,APOD,CHI3L1,COL16A1,COL8A2,CYP1B1,ESRRB,FBLN1,FBLN5,FBN2,ITGA3,LOXL1,LOXL2,LOXL4,LTBP2,MMP2,SPARC | NA |
| ANGPT2 | -6.20e-01 | growth factor | Inhibited | -3.46e+00 | NA | 0.0e+00 | ABCA1,ACTA1,ACTA2,ARHGEF2,AXIN2,BCL2L11,BCR,C1R,CASP3,Ccl2,CD86,CDC34,CDKN1A,CFB,COL18A1,COL1A1,COL3A1,CRYAB,CWC22,CXCR4,CYBA,CYBB,DBNL,DNAJB4,EDN1,ETS1,FEN1,FKBP10,FN1,GATA4,HDAC4,HIF1A,HSP90AA1,HSPA1A/HSPA1B,HSPA2,ICAM1,IL17A,INPP5F,KIF1C,KLF5,LEPR,LMNB2,LYN,MGST1,MMP2,MYH6,MYH7,MYOD1,MYOG,NCF1,NOX1,NOX4,OLR1,PDIA5,PHLDA1,POLA1,PROS1,PTGES,PTGS2,RDH10,RFC2,SCNN1G,SERPINE1,SERPING1,SNAI1,SOCS7,SPTLC3,TEK,TGFB1,THBS1,THBS2,TLR4,VCAM1,VIM | 1400 (18) |
| APLN | -1.90e+00 | other | Inhibited | -3.47e+00 | NA | 0.0e+00 | ADIPOQ,ANGPT2,ANXA2,ANXA5,CD34,CFL1,CTNNBIP1,CXCR4,EGR1,ESM1,FSCN1,GFAP,HBA1/HBA2,IRS1,ITGA2B,JUND,KDR,LAMA4,LGALS1,LRG1,MYH6,MYH7,NCF1,NKD1,PDGFB,PRDM16,PTP4A3,S100A10,SERPINH1,SOX18,SPN,TAGLN2,TEK,TESC,TMEM26,TUBA1A,VIM,YWHAQ | 1359 (23) |
| DLX1 | -3.50e-01 | transcription regulator | Inhibited | -3.47e+00 | NA | 0.0e+00 | ALDH1A1,BCL2L1,CD44,CDH1,CDH6,CTHRC1,CX3CL1,DAB2,EDIL3,EML1,ENO2,FBLN1,FGFR1,FSTL1,GAD1,KIT,LOXL2,MMP14,NUMBL,PCOLCE2,PMP22,RGS4,SDC1,SERPINE1,SMARCD3,SNAI1,SNTB1,TGFBI,VEGFC,VIM,WNT5A,ZFP36L1 | NA |
| HGF | -8.50e-01 | growth factor | Inhibited | -3.48e+00 | NA | 0.0e+00 | A2M,ACKR3,ACKR4,ACTA2,ADAMTS1,ADORA2A,AHR,AKAP12,ANGPT2,ANGPT4,ARRDC3,ASNS,ATF3,BCL2A1,BCL2L1,BIRC3,BUB1,BUB1B,CA9,CALCR,CALCRL,CASP1,CASP8,CAV1,Ccl2,CCND1,CCNE2,CD28,CD44,CD93,CDC14A,CDC25B,CDH1,CDK2,CDKN1A,CDKN2C,CELSR1,CENPF,CITED2,COL1A1,COL2A1,COL3A1,CRYAB,CSF1,CTSK,CXCR4,DKC1,DOK5,DUSP1,DUSP6,DYNLL1,EBP,EDN1,EGR1,EMP1,EMP2,ENTPD1,EPHA4,ERRFI1,ESM1,ETS1,F3,FEN1,FGF16,FKBP5,FLNA,FN1,FOXN2,GAB1,GNA13,GPSM2,GRK5,HGF,HK1,HLX,HOMER1,HTR7,ICAM1,IER3,IGF1,IGFBP4,IGHMBP2,IL15RA,INHBA,IRF8,IRX5,ISG15,ITGA2,ITGA6,KIF11,KITLG,KLF6,KRT19,L1CAM,LAMC2,LY75,MAPK14,MAT2A,MEOX2,MET,MID1,MKI67,MMP14,MMP2,NAB2,NOP2,NR0B2,NR4A1,NR4A2,NR4A3,NR5A2,NRCAM,NRP1,OCLN,OSMR,PEX5,PGK1,PHLDA1,PLK1,PLK4,PLPP3,PMP22,PPAN,PPARD,PRC1,PRKAA1,PRKDC,PTAFR,PTGS2,PTPRF,RFC2,RGS2,RGS20,RUNX2,SELE,SEMA3A,SERPINE1,SFRP1,SGK1,SIX4,SKP2,SLC19A2,SLC20A1,SLC7A1,SMC2,SNAI1,SOCS3,SPP1,ST14,TAGLN2,TBC1D8,TGFA,TGFB1,THBD,THBS1,TIMP1,TNFAIP2,TNFAIP6,TP63,TRIB1,VCAM1,VEGFC,VIM,ZFP36 | 1076 (14) |
| PRMT1 | 3.60e-01 | enzyme | Inhibited | -3.48e+00 | NA | 0.0e+00 | ACTA2,ADIPOQ,ALOX12,APCDD1,AXIN2,Ccl2,CCND1,CDH1,CDH2,CLDN1,CNP,COL1A1,COL3A1,COX4I1,Cox8b,CXCL16,EBF2,FN1,FTL,GCLC,HSP90AA1,IGFBP6,ITGA2B,KLF4,LOXL1,MAG,MRC1,NKD1,PDK4,PPARG,PRDM16,SERPINE1,SLC45A3,SMAD7,SNAI1,SNAI2,SOX10,VIM,ZEB2 | 1331 (21) |
| PARP1 | 2.90e-01 | enzyme | Inhibited | -3.48e+00 | NA | 0.0e+00 | ABCA1,BRCA2,Ccl2,CCND1,CCR5,CD83,CD86,CDH1,CDKN1A,COL1A1,COL3A1,CXCL10,CXCL12,CXCL13,DNAJC12,FOXP3,GBP2,GBP4,GBP7,HAS2,HRH1,ICAM1,IGF1,IL17A,IL18BP,IL2RA,ITGAL,MITF,MMP2,NFAT5,PFDN1,POLA1,PTGS2,PVALB,RAPGEF4,SELP,SFTPB,SLC38A2,SNAI1,SOCS1,STAT1,TGFA,TIMP1,TLR4,TMOD3,VCAM1,VEGFC | 1295 (16) |
| FGF2 | 1.91e+00 | growth factor | Inhibited | -3.50e+00 | NA | 0.0e+00 | ACER2,ACTA2,ACTC1,ADAMTS5,AGL,ANGPT2,ANPEP,AXIN2,B2M,BAMBI,BCL2L1,BCL6,BDNF,BGN,BMP4,BTG2,CALB1,CAV1,CBFB,Ccl2,CCNA2,CCND1,CCND2,CD34,CDH1,CDH11,CDK2,CDKN1A,CNMD,CNP,COL1A1,COL3A1,CRYAB,CSF1,CSPG4,CTSK,CXCL12,CXCR4,CYGB,DAD1,DCN,DLL1,DMP1,DUSP6,EDNRB,EGR1,ELN,EPHA4,ERRFI1,ETS1,ETV1,ETV5,F3,FBN1,FGF2,FGFR1,FLNA,FN1,FOXO1,FOXO3,GADD45A,GAP43,GCH1,GFAP,GLI1,GPNMB,GREM1,GRIK4,HAS2,HGF,HIF1A,HPSE,ICAM1,ID2,IGF1,IGFBP4,IGFBP5,INHBA,IRS1,ITGA1,ITGA3,ITGA4,ITGA5,KCNC1,KDM2B,KDR,KIT,Ldha/RGD1562690,LEF1,LOX,MACROD1,MAFA,MEOX2,MET,MITF,MKI67,MMP2,MPZ,MYCN,MYF5,MYOD1,MYOG,NKD1,NOTCH4,NR4A1,NR4A2,NR5A2,PAX3,PDGFB,PDGFC,PDGFRA,PENK,PGK1,PITX2,PLAT,PLK2,PLXDC1,Podxl,PPARG,PRKCD,PRKCE,PRKDC,PTGS2,RET,RUNX1,RUNX2,S100A10,S100A4,SDC1,SDC2,SELE,SEMA6D,SERPINE1,SFRP1,SFRP2,SLC20A1,SLC2A1,SLC41A2,SNAI1,SNAI2,SOCS3,SPARC,SPHK1,SPP1,SPRY4,ST3GAL1,STAR,TAGLN,TFCP2L1,TGFB1,THBS1,TIMP1,TOP2A,TPO,TSHR,TWIST1,TWIST2,VCAM1,VEGFC,VIM,VWF,WNT10B,WNT16,WNT4,WNT5A,YWHAQ,ZEB2,ZFP57 | 1521 (19) |
| KLF4 | -1.16e+00 | transcription regulator | Inhibited | -3.52e+00 | NA | 0.0e+00 | ABHD5,ACTA2,ACTC1,ACVR1,ADAMTS1,ADGRE1,ADRB2,AIF1,ALCAM,ALDH1A1,APCDD1,ARG1,ATP2A2,BCL11B,BCL2L1,BUB1B,CASP3,CBFA2T3,Ccl2,CCNA2,CCND1,CCND2,CD34,CD44,CDH1,CDKN1A,CHST15,CLDN1,CLIC4,COBLL1,COL1A1,COL8A1,CSF1R,DLL1,DUSP1,DUSP5,ECSIT,EMX2,ESRRB,ETV1,EYA1,FABP1,FARP1,FN1,FRZB,GADD45A,GATA4,GBP4,GJB2,GLI2,GRHL1,HEY2,IER5,IFITM3,IL17A,IL7,INHBA,IRF6,IRS1,ITGAD,KDR,KLF4,KLF5,KRT19,LGR5,MRC1,MRPS18B,MSI2,MYH6,MYH7,MYOCD,NEK9,NOTCH4,NRP1,Oasl2,PAX3,PCDH18,PDGFRA,PITX2,PLAT,POLE4,POLR3G,PRDM1,PROM1,RUNX2,SEMA3F,SERPINE1,SERPINH1,SMAD7,SNAI2,SOCS1,SPHK1,TAF1C,TAGLN,TBX3,TEK,TGFB1,THBD,THBS1,TNC,TNFRSF19,TWIST2,UGDH,USP18,VCAM1,VIM,WLS,WNT5A,ZNF48 | 1557 (23) |
| REL | -7.80e-01 | transcription regulator | Inhibited | -3.52e+00 | NA | 0.0e+00 | AHR,ARFGAP3,B2M,BARD1,BCL2A1,BCL2L1,BCL3,CACNA1E,CAMK2D,CCND1,CCND2,CD200,CD86,CDH1,CDKN1A,CIITA,CMPK1,COTL1,CREM,CTU2,CXCL10,EDARADD,EGR2,EPHB2,ETV5,EXOSC1,EZH2,F3,FADS2,FN1,FOXO3,FOXP3,GADD45B,GPT2,HLA-A,ICAM1,IER3,IL2RA,INSC,IRF4,IRF5,IRF6,IRF8,KCNK6,KDR,MINPP1,MYH7,NAB2,NFE2L2,NFKBIA,NR4A1,NR4A3,NRARP,PARP14,PCBP4,PHGDH,PLK2,PPP1R14B,PYCARD,RBL1,RDH10,REL,RSAD2,SLC7A6,SNAI1,SNAI2,STAT5B,TBCA,TNFRSF10A,TNFRSF4,TTC30B,UBXN2B,VIM,VTI1A | 1302 (15) |
| CD14 | -4.40e-01 | transmembrane receptor | Inhibited | -3.52e+00 | NA | 0.0e+00 | BCL2A1,Ccl2,CISH,CXCL10,CXCL12,F3,ICAM1,IFIT1,IL10RA,IL1R1,IL2RA,MSR1,PTGS2,SELE,SELP,SOCS1,SOCS3,TGFB1,TLR2,VCAM1 | 919 (13) |
| G protein alpha | NA | group | Inhibited | -3.53e+00 | NA | 1.0e-02 | ALG3,B3GALT2,CD200,CHPF,DOLK,ELK3,HSD17B12,ITM2C,LGALS12,MATN2,NDN,NMNAT2,NUCB1,PDIA4,PIM3,PLS3,QPCT,RP2,SEC13,SLC41A2,SPCS3,TCEAL8,TMED3,TMEM263,TTC26,TUBB6 | NA |
| CXCL12 | -1.56e+00 | cytokine | Inhibited | -3.53e+00 | NA | 0.0e+00 | ACP5,ACTA2,ADAM17,AIF1,ATRX,AXL,BCL2L1,BCL3,BMP1,CCND1,CD36,CD44,CD47,CD9,CDH1,CDK2,COL1A1,COL3A1,CTSK,CX3CL1,CXCL10,CXCL12,CXCR4,DAD1,DMPK,DPP4,EGR1,ERCC1,ESM1,F2R,FLNA,FN1,FYN,GAD1,GAS2,GSR,HCLS1,ICAM1,IGFBP7,IL2RA,IRF3,IRF6,ITGAL,ITGB3,ITGB4,KIT,LCP2,LOXL2,MAPRE3,MMP14,MMP2,NR4A1,Podxl,PRKCD,PTGS2,ROCK1,RPS6KB1,RUNX2,RYR1,SELE,SNAI1,SOCS1,SOCS3,SORBS3,SSBP1,THBS1,TIMP1,TNFRSF10A,TNFRSF11B,TNFRSF1B,TNNC1,VIM,ZBTB16 | 1192 (17) |
| IL12 (complex) | NA | complex | Inhibited | -3.54e+00 | NA | 0.0e+00 | ACADL,ADGRE1,AHR,BCL2L1,BCL3,CASP1,CASP3,Ccl2,CCR5,CD226,CD244,CD28,CD44,CD86,CDH1,CEACAM1,CISH,CSF1,CXCL10,CYTIP,FAAH,FGF2,FOXP3,FUT7,GADD45B,GADD45G,GCNT2,GZMB,HLX,ICAM1,IFIH1,IL17A,IL18BP,IL18R1,IL2RA,IRF1,IRF4,IRF8,ISG15,ITGA4,ITGA6,ITGAE,ITGAL,ITGB2,KIT,MMP2,PRDM1,PTGS2,RRAD,SELP,SOCS1,SOCS3,Tcf7,TGFB1,TIMP1,TLR2,TLR4,TNFRSF25 | 1248 (17) |
| EIF6 | 6.10e-01 | translation regulator | Inhibited | -3.54e+00 | NA | 0.0e+00 | ABHD15,ACOT11,ACSM3,ACSS3,ANXA2,BMP5,CD36,CERS6,COL1A1,COL3A1,COL5A2,CORO1C,COX4I1,FABP1,FADS2,FADS3,FGF9,GALNT10,GPAM,IRS1,LSS,MVD,NDUFB9,NDUFC1,PIK3CG,PPARG,RPL35,RPS15,SACM1L,SMPD3,TIMM9,TOMM7 | 407 (7) |
| Ap1 | NA | complex | Inhibited | -3.54e+00 | NA | 0.0e+00 | ADH7,ATF3,ATP6AP2,BCL2A1,BCL2L1,BCL2L11,BDNF,C3AR1,CCNA2,CCND1,CD44,CXCL12,DUSP6,EDN1,ERCC1,ETS1,EZR,F2RL1,F3,FN1,GFAP,GZMB,ICAM1,IGF1,IL2RA,IL33,ITGA2,KLF9,LPL,MET,MMP2,MSR1,MYOD1,NOTCH4,PEX13,PLA2G2A,PRDM1,PTGS2,RNF7,RSPO3,S100A4,SELE,SERPINE1,SNAI2,SOCS1,SOCS3,SPARC,TGFA,TGFB1,TIMP1,TLR4,TNFRSF8,UTRN,VCAM1,XYLT1 | 1325 (16) |
| 5-azacytidine | NA | chemical drug | Inhibited | -3.54e+00 | NA | 0.0e+00 | ANXA2,BCL2L1,BRCA2,BTG3,CASP8,CAV1,CD44,CDH1,CDKN1A,CIITA,CLDN1,COL1A1,CXCL12,DLK1,DUSP1,ECH1,ETV5,EZH2,F3,FOXO3,FOXP3,FYN,GADD45A,GSK3A,INHBA,IRF8,IRS2,ITGAL,KDR,KLF4,KLF6,LDHB,LOX,MAFF,Mt1,MYH6,MYH7,PCDHA4,PLAGL1,PTGS2,RFX1,SERPINB8,SLC26A3,SLC9A1,SOCS3,SPHK1,TFPI2,THBS1,THBS2,TNNC1,TUBB | 1310 (20) |
| SPIB | -5.00e-02 | transcription regulator | Inhibited | -3.55e+00 | NA | 0.0e+00 | ATF3,BTK,CCL24,CCR5,CD200,CD244,CD300C,CD86,CLEC4M,COL2A1,COX4I1,COX6B1,DLL1,EGR1,EGR2,Gm6377,HSPA1A/HSPA1B,IL2RA,IRF4,KDR,KIT,KLF6,LGR5,LILRB3,NEIL1,NET1,NRXN2,P2RY10,P2RY12,P2RY6,PRDM1,PRDX4,PRDX5,PTPRF,SLAMF9,TNFRSF11B,ZC3H13 | NA |
| laquinimod | NA | chemical drug | Inhibited | -3.56e+00 | bias | 0.0e+00 | ADAMTS15,ADAMTS9,AHRR,AK4,Aox3,CABLES1,CCR1,CD93,CDH1,COL13A1,CX3CL1,CYP1B1,DAB2,DPEP2,EVA1A,FKBP5,FNDC5,GPNMB,GPT2,HDC,HIC1,INHBB,LAD1,LPAR1,MB21D2,MPZL2,MSR1,OLFML2A,PMP22,PPP1R3C,RUSC2,SERPINB8,SLC9A3,STBD1,SYT15,TIPARP,TPH1,TSKU,TTC9,WNT2,WNT4 | NA |
| IFNA4 | NA | cytokine | Inhibited | -3.57e+00 | bias | 0.0e+00 | AP1S3,ATP2B4,CCRL2,CD86,CLIC4,CXCL10,GBP2,GBP5,H2-T22,H2-T24,IFIH1,IFIT1,IL17A,ISG15,MX1,OASL,PMEPA1,RSAD2,SLCO3A1,USP18 | 974 (18) |
| IL17F | NA | cytokine | Inhibited | -3.57e+00 | NA | 2.0e-02 | Ccl2,COL2A1,CX3CL1,CXCL10,CXCR4,ICAM1,IGF1,LPL,PLA2G4E,PTGS2,RUNX2,TGFB1,TNFRSF1B | NA |
| CEBPB | 2.10e-01 | transcription regulator | Inhibited | -3.57e+00 | NA | 0.0e+00 | ACTA2,ADH1C,ADH7,ADIPOQ,Akr1b7,ALDH1A1,ANTXR1,APCDD1,APLN,APLNR,ARG1,ASNS,BARD1,BCL2A1,BCL2L1,BDNF,BRCA2,BUB1B,C2,C3,C3AR1,Ccl2,CCNA2,CCND1,CCND2,CCR1,CCR5,CCRL2,CD1D,CD74,CD86,CDC25B,CDC42EP3,CDH3,CDKN1A,CDKN2C,CDO1,CEBPD,CIT,COL1A1,COL5A2,CP,CRP,CSF1R,CSF3R,CTSC,CXCL10,CXCL16,CXCR4,DAB2,DAPK1,DCN,DCTPP1,DEK,DEPDC1,DHCR7,DHRS1,DIAPH3,DYNLT1,E2F8,EDIL3,EMCN,ESPL1,EZH2,FBLN1,FBXO32,FCER1G,FCGR1A,FCGR3A/FCGR3B,FHL1,FHL2,FN1,FOXO3,FTL,FZD1,GADD45A,GFAP,GINS3,GLIPR2,GNAS,HAS2,HDC,HGF,HLA-A,Hnrnpa3,HSD17B4,HSP90AA1,HSPE1,HUS1,ICAM1,IER3,IFITM3,IGF1,IGFBP4,IKBKE,IL18BP,IL1RN,IL7,IRAK3,IRF4,IRS1,IRS2,ITGAL,KIF4A,KLF10,LBP,LCP2,LEPR,LIX1,LPIN1,LYN,MC2R,MCM7,MIA,mir-143,MKI67,MRC1,MSR1,NDRG4,NRP1,OXTR,PCTP,PDGFRA,PDK4,PEA15,PLA2G2A,PLA2G4A,PLK1,PLXND1,POLA2,POLE4,PPARD,PPARG,PRDM1,PRDX4,PRKAR2B,PRKCD,PSIP1,PSMA6,PTGES,PTGFR,PTGS2,RAC2,RANBP1,RFC2,RGS4,RUNX2,SART3,SEMA3E,SERP1,SERPINE1,SGK1,SHMT1,SLC2A1,SLC38A2,SLC7A1,SOCS3,SPC25,SPP1,SREBF1,STAG1,STAR,STAT1,STMN1,TACC3,TGFB1,TLR4,TLR8,TM4SF1,TMEM176A,TMEM176B,TNFAIP6,TNFRSF19,TOP2A,TUBB,UBE2F,USP1,USP33,VCAN,VIM,WDR90,WEE1,WNT6,XPO1,ZNF638 | 1509 (20) |
| dimethyl sulfoxide | NA | chemical drug | Inhibited | -3.58e+00 | NA | 0.0e+00 | AATK,ALOX5,ANXA1,AQP7,BMP4,C1QTNF3,CA3,CCND2,CXCR5,DNAJB4,EIF4EBP1,EMP3,FRZB,FXN,GATA4,HEBP1,IFI16,IRS2,ITGB2,JUND,LOXL4,LPL,MYH6,MYH7,NCF1,NR2F2,PLD1,PLD2,PRKX,ROCK1,RUNX2,SELP,SLC36A2,SLC8A3,SMPD3,SPNS2,STAR,TBX5,Tcf7,TNFRSF11B,TNNC1,Tpm1,UBE2L6,VCAM1 | 1434 (20) |
| Hedgehog | NA | group | Inhibited | -3.58e+00 | NA | 0.0e+00 | ABCC8,BDNF,CCNA2,CCND1,CCND2,FOXC2,GATA4,HOXA5,JAG1,KCNJ11,KIT,KLF4,KRT19,MAFA,MYCN,NKX6-1,PRKCI,PTCH1,SPP1 | 463 (8) |
| LHX1 | NA | transcription regulator | Inhibited | -3.58e+00 | bias | 2.0e-02 | ANPEP,ATP1B1,CXCL12,CXCR4,DAB1,DPP4,EMB,FN1,FZD5,GAD1,GATM,GCNT1,HHEX,Hnrnpa3,JAG1,KCNJ15,MMP2,MSI2,OVOL2,PDPN,SEMA6D,SFRP1,SIM1,SLC45A4,SLC47A1,SNAI1,SOSTDC1,TMEM229A,TWIST1 | NA |
| SMTNL1 | -1.60e-01 | other | Inhibited | -3.59e+00 | NA | 0.0e+00 | ACTA1,AGL,Calm1 (includes others),GAPDH,GLO1,MYL1,MYOM2,OXTR,PTGS2,PYGM,TNNC2,TNNI2,Tpm1 | NA |
| HRG | NA | other | Inhibited | -3.59e+00 | bias | 0.0e+00 | CCL24,Ccl6,CD74,CD83,CXCL14,CXCR4,FCGR1A,FCGR3A/FCGR3B,HLA-DQA1,SNAI1,SPARC,SPP1,TIMP1 | 857 (7) |
| 2-bromoethylamine | NA | chemical reagent | Inhibited | -3.59e+00 | NA | 0.0e+00 | A2M,ADAMTS1,ANXA1,ANXA2,CD44,CP,EMP3,FBLIM1,GCGR,GPNMB,IER3,LAMC2,MRC1,PLA1A,S100A10,S100A11,SPP1,TIMP1,TMSB10/TMSB4X,TSPAN8,TUBB,VIM | NA |
| THRA | 4.10e-01 | ligand-dependent nuclear receptor | Inhibited | -3.60e+00 | NA | 0.0e+00 | ACTA1,ATP2A2,BMP4,CASP3,CASP8,Ccl2,CCND1,CD44,CDKN1A,COX4I1,CTSH,CXCL10,DIO1,ENG,Esrra,FGFR1,FRZB,GPD2,IGF1,IL7,INHBA,IRF1,KLF9,LAMP2,LPL,MAFA,MC4R,MLKL,MYF5,MYH2,MYH6,MYH7,MYOD1,NCF1,NLRP3,NOX4,PENK,PPARG,PROM1,PTAFR,RCAN2,RIPK3,SERPINE1,SFRP2,SLC9A1,SREBF1,TGFB1,TRADD,WNT10B | 1532 (24) |
| SIM1 | 1.71e+00 | transcription regulator | Inhibited | -3.60e+00 | bias | 0.0e+00 | ABCG1,ABI1,ANGPT2,AOX1,AQP4,AQP7,ARNT2,CACNG1,CAMLG,CBFB,CCR1,CCS,CD86,CDH3,CELF2,CFL2,CMKLR1,COL11A1,COL12A1,CPXM2,CXCR5,CYBA,DLL1,EGF,EGR1,ELL2,EYA1,GLI1,GLUL,GPX3,HLA-A,HOMER1,ICAM1,IFI16,IGFBP4,ITGB3,KCNJ15,LAMA2,LCAT,LCP1,LDB2,LHX8,MCM7,MYH6,MYH7,NDUFA1,NGEF,NR5A1,NUDC,OAZ1,PDLIM4,PEA15,PFN1,PKIB,PLA2G5,PLCB1,PLP1,PMFBP1,RGS10,SELENBP1,SOX10,Sp100,SRSF1,TXNRD3,ZFP36L1 | NA |
| RICTOR | 4.50e-01 | other | Inhibited | -3.60e+00 | NA | 0.0e+00 | ATP6V0A4,ATP6V0B,ATP6V1A,ATP6V1E1,ATP6V1F,BCL2L1,BCL2L11,CDC42EP5,CDH1,CLDN1,COX4I1,COX6A2,COX6B1,EGR1,ENO2,FAU,FOXP3,HIF1A,IFI16,IL17A,IRS2,ISG15,LEPR,Mbp,MRPL13,NDUFA1,NDUFA7,NDUFAB1,NDUFB3,NDUFB9,NDUFC1,NDUFC2,Ndufs5,NDUFS7,NDUFV1,NDUFV2,NIPAL1,PFKFB3,PRKCB,PRKCE,PSMA4,PSMA6,PSMB1,PSMB5,PSMC1,PSMC5,PSMD13,PTGS2,Raet1d/Raet1e,RPL14,RPL17,RPL18,RPL22,RPL23,RPL28,RPL6,RPS10,RPS11,RPS15,RPS18,RPS2,RPS24,RPS3,SGK1,Slfn2,SNAI1,SNAI2,SREBF1,UQCR10,UQCR11,VCAM1,VIM | 1439 (19) |
| CpG ODN 1826 | NA | chemical reagent | Inhibited | -3.60e+00 | NA | 1.4e-01 | ADRB2,CD83,CD86,CIITA,CXCL10,CYBA,CYBB,FCGR1A,FCGR2B,KLHL21,NCF1,NCF2,OAS3,Oasl2,PARP14,PELI2,REL,RGS2,TLR4,TRPV1 | NA |
| RNY3 | NA | other | Inhibited | -3.61e+00 | bias | 0.0e+00 | CXCL10,EPSTI1,IFI44,IFI44L,IFIT1,IFITM3,ISG15,MX1,OAS3,OASL,RSAD2,RTP4,SERPING1 | 856 (7) |
| CCL20 | NA | cytokine | Inhibited | -3.62e+00 | bias | 0.0e+00 | C3,C3AR1,CASP1,Ccl2,CDH1,CX3CR1,CYBB,FCER1G,FCGR1A,GBP5,IL1RN,MYO5A,NCF1,NLRC4,NLRP3,OLR1,PIK3CG,PLA2G2D,PLA2G7,SYK,TLR4,VIM | 894 (14) |
| ROCK1 | -9.50e-01 | kinase | Inhibited | -3.63e+00 | bias | 0.0e+00 | ACTA1,ALOX12,CCND1,CCND2,CD44,CNN1,COL1A1,COL3A1,COL5A1,COL8A1,EDN1,ETS1,FBN1,ICAM1,LAMA2,LAMA4,MYH7,VCAM1 | 1314 (19) |
| GIP | NA | other | Inhibited | -3.63e+00 | NA | 0.0e+00 | ADIPOQ,ATF3,Ccl2,Ccl7,CXCL10,GBP2,GBP5,Ifi47,IKBKB,IL1RN,LPL,OASL,PPARG,PRDM16,RGS2,RSAD2,SERPINE1,SOCS3,SPP1,STX11,Tcf7,TNFRSF1B | 995 (19) |
| COPS5 | 5.40e-01 | transcription regulator | Inhibited | -3.63e+00 | NA | 0.0e+00 | ADRM1,AEN,AK1,AMD1,ATF3,ATRX,BUB1,CCNA2,CDKN1A,CDKN2C,CENPF,CETN2,DCTPP1,DDIT4,DEPDC1,DIAPH3,EDF1,EPS8L2,ESPL1,F2R,FAM162A,FCER1G,GTF2F1,GTF3C5,GUK1,HIF1A,HNRNPU,IER5,INHBB,KIF11,KIF23,LDHB,MCM7,MKI67,MRAS,NINJ1,PLK3,PLK4,PMM1,POLE4,POLR2E,POLR2F,POLR2J,RFC2,RPL18,RPL36,RXRA,S100A10,S100A4,SESN1,SLC19A2,SMC2,SPHK1,STMN1,TAF1C,TM4SF1,TOP2A,USP1,VPS28,ZFP36L1 | 1351 (15) |
| IFNAR1 | -4.90e-01 | transmembrane receptor | Inhibited | -3.63e+00 | NA | 0.0e+00 | ARG1,ATF3,AXL,B2M,CCL24,CD86,CIITA,CSF1,CXCL10,CXCL13,DLL1,DUSP6,FAP,FN1,GBP4,HLA-A,IFI16,IFI44,IFIH1,IL17A,IRF1,ISG15,OAS3,OASL,Oasl2,PLA2G7,PLAT,PTGS2,RSAD2,RTP4,SDC1,SERPINE1,SMAD7,SOCS1,SOCS3,Sp100,STAT1,THBS1,TLR2,TLR7,TNFAIP2,USP18,VCAM1,VCAN | 1106 (17) |
| lipid A | NA | chemical toxicant | Inhibited | -3.64e+00 | bias | 0.0e+00 | ABCA1,C2,C3,Ccl2,CD36,CD86,CXCL10,FCGR1A,FCGR2B,ITGA5,LYN,MSR1,OLR1,PRKCD,PTPRC,SYK,THBS1 | 1199 (16) |
| IFN type 1 | NA | group | Inhibited | -3.65e+00 | NA | 2.0e-02 | BCL2L1,BCL6,Ccl2,CX3CL1,CXCL10,CXCL13,DHX58,IFI16,IFIH1,IFIT1,IRF1,ISG15,OASL,STAT1,UBA7 | NA |
| FEV | NA | transcription regulator | Inhibited | -3.65e+00 | bias | 0.0e+00 | ANXA2,CALCR,CXCR4,EFNA5,GPR176,ICAM1,JAM2,LPAR1,NLGN3,NMNAT2,NR2F2,NTN1,NTS,PROX1,RORB,SCN3B,SEMA3E,SLC18A2,SLC1A3,SLC22A3,SLC7A8,TACR3,TPH1,TRPV2,VCAM1,VIM | NA |
| lomustine | NA | chemical drug | Inhibited | -3.66e+00 | NA | 0.0e+00 | A2M,A3GALT2,ANXA1,ANXA2,ASNS,Bex2/LOC100912195,BIRC3,CD44,CP,EMP3,FBLIM1,GCGR,GPNMB,IER3,ITGB4,LAMC2,PLA1A,S100A10,S100A11,SPP1,TES,TIMP1,TMSB10/TMSB4X,Tpm1,TSPAN8,TUBB,VIM | NA |
| ESR2 | 7.90e-01 | ligand-dependent nuclear receptor | Inhibited | -3.66e+00 | NA | 0.0e+00 | ABCA1,ABCC4,ABLIM1,ACKR3,ACSL3,ACTC1,ADAMTS1,ADAMTS5,ADH7,AKAP12,ALDH1A3,ANK1,ANO2,ANPEP,ANXA1,ARHGDIB,ARID5B,ARNT2,ATF3,B4GALT1,BAMBI,BANF1,BCAT1,BCL2L1,BIN1,BMP15,BMP4,BMP5,BRCA2,BTG2,C3,C8orf44-SGK3/SGK3,CA12,CACNA1D,CALU,CAV1,CBFA2T3,CCNA2,CCND1,CCR5,CD34,CD93,CDC14B,CDH1,CDH2,CDK5R1,CDK6,CDKN1A,CDKN2C,CEBPD,CHST15,CLDN1,CNN1,COL11A1,COL13A1,COL16A1,COL1A1,COL7A1,CSF1,CTHRC1,CTSH,CXCL12,CXCL16,CYP26B1,CYTH4,DAB2,DDAH1,DEK,DHCR7,DMTN,DNAH11,DNAJC1,DOCK10,DPYSL3,DUSP10,EDN1,EGR1,EGR3,ELL2,ELOVL5,EMB,EMP3,ENPP3,EPHA3,ETV1,EXOSC1,EXOSC5,EXOSC7,EYA4,EZH2,F2RL1,FADD,FADS1,FBLN1,FBLN5,FBN1,FGF2,FGFR1,FHL1,FKBP5,FMOD,FN1,FOXC2,FOXO1,FOXO3,FSCN1,FSTL1,FZD2,GADD45B,GALNT7,GATA4,GBP2,GCLC,GFAP,GGCT,GLRX,GM2A,GPNMB,GPSM2,GPX3,GREM1,HEBP1,HOMER2,HRAS,HSD17B4,HSPA2,IFI44,IFIH1,IGF1,IGFBP4,IGFBP5,IKBKB,IL1R1,INPP4B,IP6K3,IQGAP2,IRS2,ITGA2,JAG1,KCNT2,KDELR3,KDR,KIF4A,KIT,KITLG,KLF4,KLHL38,KRT19,LIMCH1,LOX,LOXL1,LOXL4,LPL,LSM4,LTBP1,LYN,MAF,MAP2K2,MAP7,MAPK14,MAPK3,MAPK4,MCM7,MDK,ME2,MGAT3,MKI67,MME,MMP14,MMP2,MPP7,MRPS18B,MSLN,MTHFD2,MYH3,MYH6,MYH7,MYOD1,NEDD9,NFKBIA,NFYA,NR4A3,NRP2,OCLN,PARP14,PCOLCE,PDGFB,PDK4,PKIB,PLAT,PLK1,PLK4,PLXDC1,PMEPA1,POLE3,PPP1R3C,PROM1,PSMA4,PTGFR,PTGIS,PTGS2,PTX3,PYGL,RARA,RASSF10,RASSF2,RDH10,REL,RELN,RETN,RGCC,ROCK1,RP2,RSAD2,RUNX2,SCUBE1,SDC4,SEC24D,SELE,SEMA3B,SEMA3F,SERPINE1,SERTAD4,SFRP4,SGK1,SKP2,SLC10A3,SLC12A4,SLC38A2,SLIT3,SMAD7,SMC2,SMOC1,SNAI2,SOCS3,SORD,SPCS3,SPDEF,SPHK1,SPP1,ST8SIA4,STMN1,SUSD4,TACC3,TESK1,TGFA,TGFB1,THBS1,THBS2,THBS4,TIMP1,TMEM229B,TMPRSS2,TNFAIP8,TNFRSF11B,TRIB1,TWIST1,UAP1,UBE2E1,USP1,USP19,VAV3,VCAM1,VIM,VWF,WEE1 | 1953 (20) |
| P38 MAPK | NA | group | Inhibited | -3.67e+00 | NA | 0.0e+00 | ABCA1,ADAM17,ADIPOQ,ANK1,ANXA5,AQP4,ATF3,BCL2A1,BCL2L1,BDNF,BGN,CAV1,Ccl2,CCL24,CCND1,CCND2,CD1D,CD36,CD44,CD83,CD86,CDKN1A,CEBPD,COL3A1,CTSK,CXCL10,CXCL12,CXCR4,CYBB,DUOX2,DUSP1,EDN1,EDNRB,EGR1,EGR2,F3,FADD,FBXO32,FGF10,FGF2,FLNA,FN1,GCLC,HAS2,HIF1A,HOMER1,ICAM1,IER3,IGFBP5,IL17A,IL1RL1,IL1RN,IL2RA,INHBA,IRF6,ITGA4,ITGB2,ITGB3,ITGB4,JAM2,KDELR3,KLF15,KLF4,KLF5,LAMA3,LBX1,MAL,mir-143,MITF,MMP2,MYBPH,MYH2,MYH3,MYOG,NFAT5,NFATC4,NFE2L2,NOX1,NPR1,NR4A1,NR4A3,OCLN,PLA2G4A,PLA2G7,PPARG,PRDM1,PTGS2,PTPN12,RAB7A,RAB7B,RARA,RGS4,RND3,RRAD,RUNX1,RUNX2,RYR1,SDC2,SELE,SERPINE1,SGK1,SNAI1,SOCS3,SPP1,STAT1,TGFA,TGFB1,THBS1,TIMP1,TLR2,TNNC1,TNNC2,TNNI1,TOP2A,TRADD,TRIB1,TRPC3,TWIST1,VCAM1,VEGFC,WNT5A,ZFP36 | 1556 (17) |
| HIF1A | -1.04e+00 | transcription regulator | Inhibited | -3.67e+00 | NA | 0.0e+00 | ABCC8,ACTA2,ADAM10,ADAM17,ADAMTS1,ADIPOQ,AHR,AK4,AKAP12,ALDOA,APLN,AQP4,ASNS,ATP2A2,AXIN2,AXL,BCL2L1,BCL6B,BGN,BHLHE40,CA9,CAV1,Ccl2,Ccl7,CCND1,CCR5,CCRL2,CD36,CD44,CDH1,CDH2,CDKN1A,CHKA,CITED2,CLDN1,CORO1A,COX4I1,COX6A2,CSF1,CXCL10,CXCL12,CXCR4,CYP2S1,D2HGDH,DDIT4,DTX1,EDN1,EDNRB,EGLN1,EIF5A2,ENG,ENO2,ENO3,ENTPD1,ESRRG,ETS1,FAM162A,FHL1,FHL2,FHL3,FN1,FSCN1,FUT7,FYN,FZD2,GADD45B,GAPDH,GBE1,GPI,HIF1A,HIF3A,ICAM1,ID2,IFI16,IGF1,IGFBP5,IL17A,IL17RA,IL7,INHBB,IRF3,IRF5,IRS2,ITGA1,ITGA2B,ITGA5,ITGB2,ITGB3,KDM3A,KDM4B,KITLG,KRT19,L1CAM,LGALS1,LIMS1,LOX,LOXL1,LOXL2,MAF,MAFF,MB,MCM7,MET,MITF,MKI67,MMP2,MYH7,NDUFC2,NDUFV1,NEFL,NEK8,NFKBIA,NOX4,NR4A1,NR4A3,NRARP,NTN1,NTRK2,PDGFB,PFKFB3,PFKFB4,PGAM2,PGK1,PKM,PLOD2,POLG,PPARG,PPIA,PRKAR2B,PROM1,PTGIS,PTGS2,REL,RET,SDC4,SERPINE1,SFRP1,SIRT2,SLC16A3,SLC27A1,SLC2A1,SMAD7,SNAI1,SNAI2,SOCS3,SPHK1,SSBP1,ST3GAL1,STAT1,TBX5,TGFA,TGFB1,THBS1,TIMP1,TLR2,TMEM45A,TNFAIP2,TNFRSF11B,UQCR10,UQCR11,VCAM1,VEGFC,VIM,WNT10B,ZDHHC9,ZNF608 | 1516 (16) |
| phenylbutazone | NA | chemical drug | Inhibited | -3.67e+00 | NA | 0.0e+00 | A2M,A3GALT2,ADAMTS1,ANXA1,ANXA2,ASNS,Bex2/LOC100912195,CCND1,CD44,CP,FBLIM1,GCGR,GPNMB,IER3,ITGB4,LAMC2,MRC1,PLA1A,PTGS2,S100A10,S100A11,SPP1,TIMP1,TMSB10/TMSB4X,TSPAN8,TUBB,VIM | 1075 (13) |
| epicatechin | NA | chemical drug | Inhibited | -3.68e+00 | NA | 0.0e+00 | ACTG1,ADIPOQ,AGPAT2,AQP7,COL1A1,COL3A1,COL5A1,COL5A2,CYB5R2,DSE,FBN1,HACD2,HTRA3,LAMA4,LGALS12,LPL,NADK,NFE2L2,NID1,NNMT,NT5C2,PLIN1,PPARG,PRELP,PTGS2,PTPN6,QPRT,RPL35,SCX,SMOC1,SPARC,ST3GAL1,SULF2,SVEP1,ZNF18,ZNF48 | 1037 (17) |
| STAT3 | -3.10e-01 | transcription regulator | Inhibited | -3.70e+00 | NA | 0.0e+00 | A2M,ACTA2,ADIPOQ,AHR,ALDH1A1,ALDH1A3,ALOX15,AMPD3,ANGPT2,APLN,ARG1,ATP10A,ATP6AP2,BATF,BCL2L1,BCL2L11,BCL3,BCL6,BOC,C3,C5AR1,CA9,CAMK2D,CASP1,CASP3,Ccl2,CCND1,CCND2,CCR1,CCR5,CCRL2,CD226,CD44,CD74,CD83,CD86,CD9,CDH1,CDH11,CDH2,CDKN1A,CDON,CEACAM1,CEBPD,CEP70,CFB,CFH,CHI3L1,CHL1,CIITA,COBL,COL1A1,COL3A1,COL5A1,CP,CREB1,Crip2,CRP,CTSK,CX3CL1,CXCL10,CXCL13,CXCL14,CXCR4,CXCR5,CYP1B1,DDIT4,DLL1,DMBT1,DPP4,DUSP1,DUSP5,E2F7,EBF1,ECT2,EDN1,EGR1,EGR2,EGR3,ENO2,F3,FAM102A,FBN1,FCER1G,FCGR1A,FGF2,FGL2,FLRT3,FN1,FOXP3,FSCN1,FZD1,GADD45A,GADD45G,GAP43,GBE1,GBP2,GBP5,GFAP,GPR65,GZMB,H2AC18/H2AC19,HAS2,HEG1,HERC6,HGF,HIF1A,HLA-A,HLA-DQA1,HTR2A,HYAL1,ICAM1,ID2,IFI16,IFI44,IFIH1,IFIT1,IFITM3,IGFBP5,IKBKE,IKZF2,IL17A,IL17RA,IL18R1,IL1R1,IL1RN,IL2RA,IL2RB,IL33,IL7,IRF1,IRF4,IRF5,ISG15,ITGA5,ITGA6,ITGB2,JAG1,KDR,KLF4,KLF5,LBP,LCAT,LDHB,LEPR,LGI2,LOX,MAF,MAP2,MGST2,MITF,MMP2,MRAS,Mt1,MX1,MYF6,MYH7,MYOD1,MYOG,NDN,NFIL3,NOX1,NOX4,NR4A2,NRP1,NRP2,NUMBL,OAS3,OASL,PAX3,PCOLCE2,PDGFB,PDIA4,PGK1,PHLDA1,PLA2G2A,PLA2G4A,PLAGL1,Pmaip1,POLE4,PON2,PRDM1,PROM1,PSIP1,PSMB5,PTAFR,PTGS2,PTN,PTPN6,PTPRF,PTX3,RAB27A,RAB31,RALGDS,RET,RSAD2,RUNX1,SALL4,SBNO2,SDC4,SELP,SEMA6D,SERPINB9,SERPINE1,SFTPB,SGK1,SKP2,SLAMF1,SLC16A1,SLC1A3,SLC22A3,SLC2A1,SLC2A5,SLC39A10,SLC9A3,SLFN13,Slfn2,SMAD6,SMAD7,SMAD9,SNAI1,SNAI2,SOCS1,SOCS3,SOX6,SP110,SPP1,SREBF1,STAT1,TAGLN,TFPI2,TGFB1,THBD,THBS1,THBS2,TIMP1,TNFRSF1B,TWIST1,USP18,VCAN,VEGFC,VIM,VTCN1,WIPF1,WNT5A,XPNPEP2,ZFP36 | 1459 (16) |
| CSF | NA | group | Inhibited | -3.71e+00 | bias | 0.0e+00 | BCL2A1,C3,CCR1,CCRL2,CD22,CSTB,DUSP10,FCGR1A,IL10RA,IL1RL2,IL1RN,IL2RG,IRAK2,IRAK3,PPARG,SERPINB8,SERPINB9,SERPINE1,SOCS3,SPN,TNFAIP6 | NA |
| LARP1 | 5.90e-01 | translation regulator | Inhibited | -3.71e+00 | bias | 3.0e-02 | EEF1A1,EEF1D,RPL14,RPL17,RPL18,RPL22,RPL23,RPL28,RPL35,RPL36,RPL37A,RPL6,RPS11,RPS15,RPS15A,RPS16,RPS18,RPS2,RPS24,RPS3,VIM | NA |
| IL27 | -2.80e-01 | cytokine | Inhibited | -3.71e+00 | NA | 0.0e+00 | ADGRE1,AHR,B2M,CCND2,CD74,CD86,CEBPD,CIITA,CX3CL1,CXCL10,EGR1,EGR2,FOXP3,GADD45G,GBP2,GZMB,HLA-A,HLA-DOB,HLA-DQA1,HLA-DRA,ICAM1,ID2,IFNLR1,IL10RB,IL15RA,IL17A,IL18BP,IL1RN,IL2RA,IRF1,MAF,MRC1,MX1,PRDM1,PTGS2,SOCS1,SOCS3,STAT1,TNFRSF4,TNFSF18,VCAM1,VIM | 1239 (17) |
| JUN | -5.30e-01 | transcription regulator | Inhibited | -3.71e+00 | NA | 0.0e+00 | A2M,ACP5,ACTA2,ADH7,AKAP12,ALOX12,ANKRD1,ANKRD2,ANXA1,ANXA2,ARG1,ASNS,ATF3,AXL,BCL2A1,BCL2L11,BCL3,BCL9,BDNF,BIRC3,BTG1,C3,C3AR1,C5AR1,CA3,CAV1,Ccl2,Ccl7,CCNA2,CCND1,CCND2,CD244,CD44,CDH1,CDH11,CDH2,CDK5R1,CDKN1A,CHL1,CMTM5,COL1A1,Crip2,CSF1,CSF1R,CX3CL1,CXCL10,CXCL16,CYGB,CYP1B1,Dgcr6,DUSP1,DUSP5,DUSP6,E2F7,EDN1,EHD4,ERCC1,EZR,F3,FBLN5,FGF2,FN1,FOLR2,FOXC1,FOXO3,FRZB,GADD45A,GAP43,GCLC,HK1,HNRNPU,HOMER1,ICAM1,ID2,IFI16,IGF1,IGFBP4,IGFBP6,IGFBP7,IL1RL1,IL2RA,IRAK3,IRS2,ITGAD,ITGB4,KDR,LAMP2,LBP,LGR5,LMO1,LPAR1,LPIN1,LTBP1,MAF,MAFA,MAOB,MAPK3,MAT2A,MET,MMP2,MPZ,MSR1,MVD,MYH6,MYOD1,NCAM1,NCF2,NFKBIA,NR0B2,NR4A1,NR5A2,NRAP,NRCAM,NTS,OXTR,PEA15,PENK,PKIB,PLA2G4A,PLAGL1,Pmaip1,PRDX1,PRKCE,PTGES,PTGS2,PTPN6,PTPRD,PTPRO,PTX3,PXDN,RAB31,RARA,RARG,RASGRF1,RGN,RNF7,RUNX2,RXRA,S100A10,SDC1,SERP1,SERPINB9,SERPINE1,SGK1,SLC2A1,SLC38A2,SLC7A1,SMAD7,SNAI2,Snrpc,SNRPN,SOCS3,SPARC,SPHK1,SPP1,STAR,STAT1,STAT6,STMN1,SULF2,SYK,TGFB1,THBS1,TIMP1,TNC,TNFRSF10A,TNNC1,TWIST1,VAV3,VCAM1,VEGFC,VIM,WNT16,WNT4,WNT5A,WNT9A,XYLT1,ZEB2,ZFP36,ZNF385A | 1621 (20) |
| Nfat (family) | NA | group | Inhibited | -3.72e+00 | NA | 0.0e+00 | ACP5,ATF3,B4GALT1,CALCR,CCND1,CTSK,CX3CL1,CYBB,DAAM1,DHRS9,DKK3,DOCK10,EGR2,EHD4,ELL2,ESM1,F2RL1,FHL1,FOXP3,ICAM1,IL17A,IRF4,KLF6,LBH,MB,NCOA7,NOX4,PDE3B,PDGFB,PGM2L1,PTGS2,RNF128,SDC4,SELE,SERPINE1,SLC7A1,TLR10,TNNI1,TNNT2,VCAM1 | 1055 (18) |
| F3 | -1.49e+00 | transmembrane receptor | Inhibited | -3.72e+00 | bias | 0.0e+00 | ARG1,Ccl2,DUSP6,EGR1,F3,FOXC2,ICAM1,ITGA2,LCP1,LEF1,MDK,MMP2,MSLN,PLPP3,RHOA,SELE,SEMA3A,SERPINE1,SPRY4,UBASH3B,VCAM1 | 1003 (15) |
| STAT4 | NA | transcription regulator | Inhibited | -3.73e+00 | bias | 0.0e+00 | ACADL,ACVRL1,ARFGAP3,BCL2L1,BCL2L11,BCL3,C3,CAPN5,CCNI,CCR5,CDK2,CXCL10,DAP,DDAH2,ENO2,ERRFI1,ETV5,FCER1G,FSCN1,GADD45G,GBE1,GCNT2,H2AC18/H2AC19,IER3,IFIH1,IL10RA,IL17A,IL18R1,IL2RA,IRF1,IRF4,ISG15,KDELR2,KLF9,LPIN1,MATK,MBOAT2,Mt1,NXN,PER1,PEX13,PGP,PLOD2,PRDM1,PRDM16,PYGL,RASL12,RGCC,RNF128,RRAD,S100A4,SELE,SELENBP1,SERPINE1,SH2B1,SOCS3,STAT1,Tcf7,TGFA,TIMP1,TWIST1,UNC13D,VSIR | 1223 (14) |
| ITK | -2.20e-01 | kinase | Inhibited | -3.73e+00 | NA | 0.0e+00 | AHR,CD244,CD44,CD7,CPNE7,CX3CR1,EHD4,F2R,FCER1G,FOXP3,HIF1A,HLA-A,IL10RA,IL17A,IL2RB,ITGA1,Klrc2/Klrc3,LAT2,LPAR6,LYN,MAF,MYO1F,PREX1,PRKCB,SCIMP,SLC2A1,SULF2,ZBTB16 | 1154 (18) |
| ESR1 | -2.20e-01 | ligand-dependent nuclear receptor | Inhibited | -3.74e+00 | NA | 0.0e+00 | ABCA4,ABCB9,ABCC3,ABCC5,ABLIM1,ACKR3,ACSL1,ACTA2,ACTC1,ACVR1B,ADAM17,ADAMTS5,ADD3,ADGRG6,ADH1C,AK1,ALCAM,ALOX5,ANO2,AP1S3,ARFGAP1,ARHGEF2,ARHGEF9,ARRDC3,ARSG,ATF3,ATOX1,ATP1B1,ATP6V1A,AXIN2,BCAT1,BCL2L1,BCL2L11,BCL6,BCR,BDNF,BIN1,BIRC3,BMP4,BRAP,BRCA2,BUB1,BUB1B,BYSL,C1QTNF4,C1QTNF6,C3,CA12,CACNA1D,CALB1,CASQ2,CAV1,CAV2,CBLC,CCNA2,CCND1,CCNI,CD74,CD83,CDC42EP3,CDH1,CDK2,CDK5R1,CDK6,CDKN1A,CEBPD,CENPF,CENPK,CEP70,CFL2,CGN,CISH,CIT,CLCN3,CLDN1,CLEC3A,CLIC6,CNN1,COBL,COL13A1,COL16A1,COL5A2,COL8A1,COTL1,Cox8b,CP,CPLX1,CREB1,CTSC,CTSS,CXADR,CXCL12,CYP1B1,CYP26B1,CYP7B1,DAB2,DDIT4,DHCR7,DIAPH3,DLL1,DMP1,DMTN,DNAJC1,DUSP10,DUSP11,DUSP5,EDN1,EEF2K,EGF,EGR1,EGR3,EIF5A2,ELN,EML1,ENAH,ERBB3,F2RL1,F3,FABP1,FADD,FAM102A,FAP,FARP2,FBLN1,FGF10,FGFR1,FHL1,FIS1,FLNA,FLT3LG,FMN1,FOXC1,FOXO1,FOXP3,FXYD6,FZD2,G6PD,GADD45B,GADD45G,GALNT7,GAS7,GFAP,GJB2,GLDN,GLI2,GLRX,GM2A,GNA13,GNAS,GOLM1,GPAM,GPSM2,GREM1,GRIA2,Gsta4,GULP1,HAX1,HBA1/HBA2,HEBP1,HIF1A,HIP1R,HOMER3,HOOK2,HSD17B4,HSP90AA1,HSPA2,HYAL1,ICAM1,IER3,IFI44,IFI44L,IFITM3,IGF1,IGFBP4,IGFBP5,IKBKE,IL17RA,IL2RA,INHBB,IQGAP1,IRAK2,IRF1,IRF4,IRF5,IRS1,IRS2,ITGA10,ITGA2B,ITGA6,JAG1,JAK3,JUND,KCNJ13,KCNK6,KDM4B,KHDRBS1,KIF23,KNL1,KRT19,LBP,LEPR,LGALS1,LIMA1,LOXL4,LPL,LTB4R,LTBP1,MADD,MAGI1,MALL,MAN1A1,MAP1B,MAP2,MAP2K2,MAP3K14,MAP7,MARK1,MCOLN1,MET,METTL7A,MIB2,MICOS10,MKI67,MME,MR1,MX1,MYH10,NCAPG,NCF2,NEB,NEDD9,NEK1,NFAT5,NFKBIA,NPR3,NR0B2,NR1D2,NRCAM,NUCB1,NUP210,NUP42,OBSCN,OLR1,OXTR,PALLD,PCDH18,PCNT,PDE4A,PDGFD,PDK4,PES1,PHLDB1,PITX2,PKIB,PLCB1,PLK4,PLOD2,PLXDC1,POLA1,PON3,PPARD,PPARG,PPP1R3C,PPP5C,PRKAA1,PRKAB1,PRKCD,PRKCI,PRKX,PROM1,PROS1,PSD4,PSIP1,PTCH1,PTGER3,PTGS2,PTP4A2,PTPN4,PTX3,PYGL,RAB27A,RAB31,RARA,RBBP4,RBL1,RDH10,RDH5,RDX,RERG,RET,RND1,RND3,RNF38,ROBO2,ROCK1,RP2,RPS6KB1,RSAD2,RTN4RL1,RTP4,RUNX2,S100B,SCAND1,Scd2,SCN1B,SELE,SEMA3B,SEMA3C,SEMA3F,SERPINB9,SERPINE1,SESN1,SGK1,SGO2,SGSM3,SH2B1,SHC2,SIAH2,SIGIRR,SIPA1L1,SIX1,SKP2,SLC10A3,SLC12A4,SLC16A1,SLC16A2,SLC16A3,SLC1A4,SLC38A2,SLC39A4,SLC39A8,SLC44A1,SLC7A1,SLC7A8,SLC9A3,SLC9A5,SMAD6,SMC2,SNAI1,SNAI2,SORD,SOSTDC1,SP110,SPP1,SPRY4,STAR,STAT1,STAT5B,STEAP1,STK3,STX3,TACR3,TAGLN,TBRG1,TC2N,TEK,TESK1,TGFA,TGFB1,THBS3,THBS4,TIMM13,TM4SF1,TMOD1,TMOD3,TNFAIP2,TNFAIP6,TNFRSF10A,TNFRSF11B,TPD52L1,TRAM1,TRIB1,TRPM2,TSKU,TTC9,TTLL11,UBXN10,UCN,UHMK1,UQCR10,UQCR11,USP19,VAV3,VEGFC,VIM,VPS28,WEE1,WHRN,WNK1,WNT11,WNT4,XK,ZBTB7B,ZNF367 | 1890 (20) |
| N-acetylmuramyl-L-alanyl-D-isoglutamine | NA | chemical - endogenous non-mammalian | Inhibited | -3.74e+00 | bias | 0.0e+00 | ABCA1,AOX1,AXIN2,BDKRB2,CASP1,Ccl2,Ccl7,CD200,CD86,CLDN1,DMBT1,ETS1,FZD4,ICAM1,IL2RA,ITGB2,ITGB3,MSR1,NFKBIA,NOD2,PTGS2,SNAI1 | 1347 (16) |
| Tnf (family) | NA | group | Inhibited | -3.75e+00 | NA | 0.0e+00 | ABCC3,ADAMTS5,ADIPOQ,ATF3,BCL2A1,BCL2L1,BIRC3,C3AR1,Ccl2,CCND1,CCR1,CCR5,CCRL2,CD22,CD86,CSF1,CSTB,CX3CL1,CXCL10,CXCL12,DUSP10,ESM1,F3,FBXO32,FCGR1A,GJA5,HIF1A,HTR2A,ICAM1,IGF1,IKBKE,IL10RA,IL1R1,IL1RL2,IL1RN,IL2RG,IL33,INHBA,IRAK2,IRAK3,ITGAE,JAG1,KDR,LAD1,MSTN,NFKBIA,NOD2,NOX4,OCLN,PDGFB,PPARG,PTGER3,PTGS2,RUNX2,SELE,SERPINB8,SERPINB9,SERPINE1,SOCS3,SPN,ST6GAL1,TLR2,TNFAIP6,TNFRSF1B,TNFRSF4,TRIM63,VCAM1 | 1140 (13) |
| EGF | 7.30e-01 | growth factor | Inhibited | -3.76e+00 | NA | 0.0e+00 | ABI1,ACTC1,ADAM17,ADAMTS1,AIDA,ALCAM,ALOX12,ALOX15,ANO1,ANPEP,ARHGEF2,ATF3,ATP2A2,B4GALT1,BCL2L1,BTG2,CASP1,CASP3,CAV1,Ccl2,CCND1,CCND2,CD34,CD44,CDC34,CDH1,CDH11,CDK2,CDKN1A,CEBPD,CISH,CLCN3,CLDN3,COL1A1,COL3A1,CREM,CSF1R,CSPG4,CXCL13,CXCL14,CXCR4,DAD1,DCN,DPP4,DUSP1,DUSP5,DUSP6,EDN1,EEF1A1,EGR1,EGR2,EGR3,EIF2AK3,EMP1,ENAH,ERBB3,ERCC1,ERRFI1,ETS1,EZR,F3,FAM89B,FGD4,FGF2,FGFR1,FLI1,FN1,FSCN2,FSTL1,GADD45A,GFAP,GFPT2,GGT5,GLUL,Gsta4,HAS2,HAS3,HGF,HIF1A,HOXB5,HOXD10,HRAS,ICAM1,ID2,IDH1,IER3,IGF1,IGFALS,IGFBP4,IGFBP5,IL17A,IL1R1,INHBA,IRS1,ITGA2,ITGB3,JUND,KIT,KLF10,KRT19,MAD1L1,MAPK3,MB,MET,MMP2,MYCN,MYF5,MYOD1,MYOG,NCAM1,NCF1,NPR2,NR4A1,NR4A2,NR4A3,NR5A1,NR5A2,NRP1,OCLN,OSR2,PDK4,PDPN,PER1,PFKFB1,PFKFB4,PIK3R1,PLAGL1,PLAT,PLPP3,PLXDC1,Podxl,PPARD,PPARG,PPIB,PRKDC,PROM1,PSMB1,PSMB5,PTGES,PTGS2,PTPN12,Raet1d/Raet1e,RHOA,RUNX1,RUNX2,RXRA,S100A10,S100A11,S100A4,SART3,Scd2,SDC1,SERPINE1,SFRP2,SNAI1,SNAI2,SOCS3,SPARC,SPHK1,SPP1,SPRY4,SREBF1,ST3GAL1,STAR,STAT1,SYP,SYT3,TAGLN,TFCP2L1,TFPI2,TGFA,TGFB1,THBS1,TIMP1,TNC,TNFRSF11B,TNFRSF4,TP63,TSPAN8,TWIST1,UCN,VCAM1,VCAN,VEGFC,VIM,YWHAQ,ZFP36,ZFP36L2 | 1913 (20) |
| KLF6 | -1.32e+00 | transcription regulator | Inhibited | -3.76e+00 | NA | 0.0e+00 | ACVR1B,ACVRL1,ADRM1,AHR,ALDOA,ALOX5,ANXA5,ARG1,ARID5B,ATF3,ATOX1,ATP2A2,BCKDHA,BCL2L1,BCL2L11,BCL3,BCL6,BIRC3,Calm1 (includes others),CASP1,Ccl2,CCL24,CCR1,CD44,CD83,CD86,CDH1,CDH2,CDKN1A,CFB,CHI3L1,CMKLR1,COL1A1,CSF2RA,CSF2RB,CYBB,DLK1,EGR2,ENG,ENO2,ESRRB,EXT1,GADD45B,GAPDH,GCH1,GCLC,GFPT2,GLI1,GNAI3,GNB4,HIF1A,ICAM1,ID2,IL15RA,IL17RA,IRAK2,IRF1,ITGA5,ITGB3,KLF10,LCP2,LITAF,LPAR1,LYN,MKI67,MMP14,MRC1,MSLN,NFE2L2,NFKBIA,NINJ1,NLRP3,NOD2,NR2F1,NR4A1,NR5A1,OSMR,PANX1,PARP14,PDPN,PFKFB3,PFN1,PGK1,PHLDA1,PKM,PLA2G4A,PLA2G7,PLAT,PPARG,PRDM1,PTAFR,PTCH1,PTGS2,RARG,REL,RIPK2,SDC1,SELE,SERPINB8,SERPINH1,SGK1,SLAMF1,SLC16A3,SLC25A28,SOCS1,SOCS3,TFPI2,TGFB1,TIMP1,TNFAIP2,TNFRSF1B,TNIP2,VAV3,VCAM1,VCAN | 1264 (16) |
| RELA | 2.00e-02 | transcription regulator | Inhibited | -3.80e+00 | NA | 0.0e+00 | A2M,ACTA2,ACTN4,ADAMTS5,AHR,AHRR,ALCAM,ALPK2,ANKRD1,ANKRD2,AP1B1,ARFGAP3,ARHGDIB,ATP6AP2,B2M,BCL2A1,BCL2L1,BCL2L11,BCL3,BHLHE40,BIRC3,BRCA2,BTG2,C3,CASP3,CASP8,CAV1,Ccl2,Ccl7,CCND1,CD28,CD44,CDC14A,CDH1,CDKN1A,CFB,CHI3L1,CIITA,CITED2,COL1A1,COL2A1,CRP,CRYAB,CX3CL1,CXCL10,CXCR4,CYBB,DOCK8,DUSP1,EDN1,EGLN1,EGR1,ELMO1,ELN,ERAP1,F3,FCGRT,FGF10,FGF2,FN1,FOXP3,FSCN1,GCH1,GLI2,GNA13,GP1BB,GRK5,HAS2,HIF1A,HLA-A,ICAM1,IER3,IGF1,IKBKE,IKZF2,IL15RA,IL1RN,IL2RA,INPP4B,IRF1,IRF2BP2,IRF4,ISG15,KCNT2,KIT,KLF10,LEF1,LGR5,LUM,LYN,LYST,MAT2A,MIA,MMP2,MYOD1,NFE2L2,NFKBIA,NFKBIB,NMI,NOD2,NOX1,NR4A1,NR4A2,NR4A3,OLR1,PDGFB,PKM,PLD1,PLK1,PLK3,Pmaip1,PPARG,PRDM1,PRKCD,PTGES,PTGS2,PTP4A2,PTPN6,PTX3,RASSF5,RUNX2,S100A6,SDC4,SELE,SELP,SIX4,SLC2A5,SMAD7,SNAI1,SREBF1,STAR,TERF2IP,TFPI2,TGFB1,Tlr13,TLR2,TMSB10/TMSB4X,TNFAIP2,TNFRSF10A,TNFRSF11B,TNFRSF4,TP63,TPO,TRPC6,TWIST1,TWIST2,VCAM1,VIM | 1399 (13) |
| TICAM1 | NA | other | Inhibited | -3.80e+00 | bias | 0.0e+00 | ACSL1,ATP6V1E1,BCL3,Ccl2,CCRL2,CD86,CEBPD,CFB,CXCL10,CXCL13,DUSP1,EDNRB,EGR1,ICAM1,IFI16,Ifi47,IFIT1,IKBKE,IL15RA,IL17A,IL18BP,IRF1,IRF3,ISG15,JAG1,LPAR1,MAFF,MET,MKI67,NFKBIA,NOX4,OASL,PSTPIP2,PTGS2,RIPK2,RSAD2,SELE,SERPINE1,SOCS1,SOCS3,TLR2,VCAM1,ZC3HAV1 | 1020 (15) |
| LTA | NA | cytokine | Inhibited | -3.80e+00 | NA | 1.0e-02 | Ccl2,CCL21,CD44,COL2A1,CRP,CXCL13,FOXP3,HAS2,HDC,IL17A,ITGA5,ITGB3,PDPN,PTGS2,REL,TNFRSF11B,VCAM1 | NA |
| IFN Beta | NA | group | Inhibited | -3.81e+00 | NA | 0.0e+00 | ATF3,BCL2L1,BTG2,C2,C3AR1,CAV1,Ccl2,CD22,CD74,CD83,CD86,CDKN1A,CEBPD,CPA3,CXCL10,CXCL14,CYBB,DHX58,DPP4,DUSP1,EEF1A1,ENPEP,FKBP5,FN1,HERC6,HLA-A,ICAM1,IFI16,IFI44,IFIH1,IFIT1,IL15RA,IL17A,IL1RN,IRF1,ISG15,KIT,MAL,MS4A2,MX1,MYH7,NCAPG,OAS3,OASL,OLR1,PNPT1,PPP1R3B,QPRT,RAB30,RSAD2,SERPINE1,SOCS1,SPHK1,SPP1,SPRY4,STAT1,TGFB1,THBS1,TLR4,TLR5,TLR7,TNFSF18,USP18 | 1125 (17) |
| IKBKG | 1.80e-01 | kinase | Inhibited | -3.81e+00 | NA | 0.0e+00 | ACTA1,AMPD3,ATP2A2,BIRC3,C3,Ccl2,CCR1,CEBPD,CP,CSF1,CX3CL1,CXCL10,CXCL12,CYP7B1,DCN,DUSP6,FOXC2,GBP2,GCH1,GM2A,HIF1A,HLA-A,ICAM1,IFI16,IGFBP6,IKBKE,IL1RN,ISG15,KCNH2,KLF5,Mt1,MYH6,MYH7,NFKBIA,NID1,OGN,PCDH7,PPARG,PTX3,RIPK3,Rtp3,SEMA3C,SFRP1,SGK1,SLC16A2,Slfn2,SOCS3,TMEM176B,TNFAIP2,TNFRSF1B,TPO,TSHR | 1218 (13) |
| EPAS1 | 4.00e-02 | transcription regulator | Inhibited | -3.81e+00 | NA | 0.0e+00 | ABI1,ACP5,ADIPOQ,AKAP12,ANGPT2,APLN,ARG1,AXL,BHLHE40,BIRC3,CA12,CA9,Calm1 (includes others),CAV1,CCND1,CCR5,CDC42EP5,CDKN1A,CHKA,CITED2,CKM,CKMT1A/CKMT1B,CLDN1,CNKSR2,CORO1A,CXCL12,CXCR4,CYBRD1,DPYD,DTX1,EDN1,ENO2,FGF2,FHL1,FN1,FXN,GADD45B,GBE1,GPT2,HIF1A,HOXA5,ICAM1,IGFBP5,IL2RA,IL2RB,INHBB,IRS2,Irs3,ITGA2B,ITGB3,KDM3A,KDM4B,KDR,L1CAM,LOX,LOXL2,LPL,MAFF,MB,MMP14,MYO7A,MYOM2,NEFL,NEK8,NFIL3,NRARP,OMA1,P2RY1,PDGFB,PFKFB3,PFKFB4,PKIB,PLOD2,PPARG,PTPRZ1,RET,RGS4,SERPINE1,SFTPB,SLC2A1,SPHK1,SREBF1,TEK,TGFA,TGFB1,TMEM45A,TNFRSF11B,TNFRSF4,TNFRSF8,TNNI1,VCAM1,WNT10B | 1444 (23) |
| IFNB1 | 7.00e-02 | cytokine | Inhibited | -3.83e+00 | NA | 0.0e+00 | ADAM17,AGL,ANXA5,APOBEC1,AXL,BCL2L1,BHLHE40,CALCR,CARD6,CASP1,CASP3,CASP8,Ccl2,CCR5,CD83,CD86,CDH2,CDKL2,CDKN1A,COL12A1,CREM,CRYAB,CTSK,CX3CL1,CXCL10,DHX58,DKK3,DLL1,F2R,FBN1,FGF2,FKBP9,GBP2,GBP4,GBP5,GBP7,GLIS2,GNB4,HLA-A,IFI16,Ifi47,IFIH1,IFIT1,IL17A,IL1R1,IP6K2,IRF1,IRF3,ISG15,ITGB3,MGST2,MMP2,MX1,NMI,NNMT,NOD2,Oasl2,OGN,PARP14,PARP9,PDK4,PHLDB2,PRDM1,PTCH1,PTGS2,REL,RIPK2,RNASE4,RND3,RSAD2,SLFN13,SOCS1,SPP1,STAT1,THBS1,THBS2,TIMP1,Tlr13,TLR7,TLR8,TNFRSF10A,TNFRSF4,UBA7,USP18 | 1299 (16) |
| SRF | 4.60e-01 | transcription regulator | Inhibited | -3.84e+00 | NA | 0.0e+00 | A2M,ABCA4,Abca8a,ABRA,ACTA1,ACTA2,ACTC1,ACTG1,ACTG2,AKAP12,AMD1,ANKRD1,ANO1,ASB5,ATF3,BATF,BCL2L1,BCL2L11,BICC1,BPGM,CALB1,Cald1,CCM2,CDKN1A,CEBPD,CFL1,CKM,CLDN1,CLDN3,CMA1,CNN1,CPA3,CSRP1,CSRP2,CXCR4,CYBB,DUSP5,E2F5,EGR1,EGR2,EGR3,EIF6,ETS1,ETV1,EYA2,EZR,FGF1,FHL1,FHL2,FHL3,FLNA,FOXP3,G0S2,GADD45A,GADD45G,GATA4,GCH1,GDA,GPATCH4,GPM6A,HIF3A,IGF1,ITGA1,ITGA2B,ITGA6,ITGA9,KDR,LAMA3,LBH,LEPR,LIMA1,LMCD1,LMOD1,LPL,MAP3K14,MGST1,MGST2,mir-133,mir-143,MSTN,MYH2,MYH6,MYH7,MYL1,MYL2,MYL3,MYOCD,MYOD1,MYOG,NCOA7,NECTIN1,NET1,NOX4,NR4A1,NR4A2,ODF2L,Pcp4l1,PDLIM7,PGM1,PKHD1L1,PLEKHO1,PMFBP1,PPIA,PTGS2,RND3,SCYL1,SELP,SEMA3A,SEMA6D,SLC2A1,SOSTDC1,SPTBN2,TAGLN,TAL1,TBXAS1,TGFB1I1,TMOD3,TNC,TNIP2,TNNC1,TNNT1,TNNT2,Tpm1,TST,TUBB6,VCAN,VEGFD | 1413 (20) |
| triamterene | NA | chemical drug | Inhibited | -3.84e+00 | NA | 0.0e+00 | A2M,A3GALT2,ADAMTS1,ANXA1,ANXA2,ASNS,Bex2/LOC100912195,BIRC3,CD44,CP,EMP3,FBLIM1,GCGR,GPNMB,IER3,ITGB4,LAMC2,MRC1,PLA1A,S100A10,S100A11,SPP1,TES,TIMP1,TMSB10/TMSB4X,Tpm1,TSPAN8,TUBB,VIM | NA |
| D-glucose | NA | chemical - endogenous mammalian | Inhibited | -3.84e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACADL,ACO2,ACSL1,ACTA1,ACTA2,ACTG2,ACVR1C,ADAM17,ADIPOQ,ALDOA,ANGPT2,ANO1,ANXA1,APLN,AQP7,ARG1,ART3,ASNS,ATF3,ATP2A2,ATP2B3,ATP2B4,ATP6AP2,ATP8B1,BCAT1,BCL2L1,BCL2L11,BCL2L12,BMP4,C3,C8orf44-SGK3/SGK3,CACNA1B,CACNA1D,CALB1,Calm1 (includes others),CASP1,Casp12,CASP3,CASQ2,CAV1,Ccl2,CCND1,CCND2,CD36,CDK5R1,CDKN1A,CNN1,CNR1,COL1A1,COL2A1,COL3A1,Col4a5,COX6A2,CREM,CSF1R,CTSC,CX3CL1,CXCR4,CYBA,CYBB,DAD1,DAPK3,DCN,DDIT4,DUSP1,DYNLL1,EDN1,EFHD1,EGR1,EIF2AK3,EMCN,ERFE,ERO1B,EVA1A,FAM3B,FBP2,FBXO32,FGF2,FN1,G6PD,GABARAPL1,GAPDH,GAS2,GATA4,GCGR,GCH1,GFAP,GLUL,GPAM,GPD1,GPI,GREM1,GRIA2,H6PD,HERPUD1,HGF,HIF1A,HK1,ICAM1,IDH1,IGF1,IL17A,INHBA,INHBB,IRS1,IRS2,ITGA1,ITGA5,ITGA8,JAG1,KCNF1,KDELR2,KDR,KIF5C,KLF10,LAMTOR2,LAMTOR5,LCP1,Ldha/RGD1562690,LGALS1,LMOD1,LPL,MAFA,MAP1LC3A,MIDN,MMP14,MMP2,MSR1,MSRB1,Mt1,MUSTN1,NCF1,NDUFA1,NDUFB3,NDUFB9,NEU1,NFE2L2,NKX6-1,NLRP3,NOX4,NR4A1,NR4A2,NR4A3,NTS,NUAK1,OCLN,OGT,OPTN,PARK7,PAX3,PC,Pcsk1,PCSK1N,PDGFRA,PDIA4,PFKFB3,PGK1,PGM1,PICK1,PKM,PLCB1,PLIN3,PLK3,PNPLA3,PON2,POPDC2,PPARD,PPARG,PPIB,PPP2R2B,PREB,PRKAA2,PRKCB,PRKCD,PRKCZ,PTGIS,PTGS2,PTPN6,PYCARD,RDH10,RETN,RGS2,RIPK3,RTN3,RUNX1,RUNX2,S100A4,Scd2,SCUBE3,SELE,SELENOP,SELP,SERPINE1,SGK1,Sh3bgr,SIRT2,SIRT7,SIX1,SLC1A3,SLC2A1,SLC37A4,SLC39A6,SLC39A8,SLC7A1,SNAI1,SNCA,SPHK1,SPP1,SREBF1,SRSF1,SSBP1,SUSD5,TAGLN,TAGLN2,TAS1R3,TGFA,TGFB1,THBS1,TIMP1,TKT,TLR2,TLR4,TNFRSF25,TOP1MT,Tpm1,TRIM63,TRPV4,TSPAN2,TUBB4A,UCP3,VCAM1,VCAN,VIM,WNT16,XK | 1801 (24) |
| diethylstilbestrol | NA | chemical drug | Inhibited | -3.85e+00 | NA | 0.0e+00 | ACTA1,ADGRD1,ADH1C,ADIPOQ,AHR,ALDH1A3,AMHR2,Aox3,AQP4,ARHGDIB,BCAT1,BCL6,BMP15,C3,CCL21,CCNA2,CCND1,CD200,CD83,CDKN1A,CENPF,CFB,CITED2,COL1A1,CTSK,CXCL14,CYGB,DCN,DLG3,DPYSL2,DUSP6,EGF,EGR1,EMP1,Esrra,ESRRB,F3,FBLN1,FMOD,FRZB,GADD45A,GAP43,GATA4,GDF10,GJB2,GLRX,GREM1,HDC,HIC1,HLA-A,HTRA3,IGF1,IGFBP6,INHA,INHBA,INHBB,IQGAP3,IRS1,ITGAE,KDR,KIF11,KIF4A,KLF4,Ldha/RGD1562690,LGALS1,LTBP2,LUM,MAN2A1,MAPK3,Marcks,MKI67,MMP2,MOXD1,NR4A3,NR5A1,NTRK2,NUMBL,OLFML2A,OXTR,PAIP2B,PAMR1,PARD6G,PCOLCE,PDGFB,PDGFRA,PRDM1,PROM1,RGS4,RIDA,RUNX1,S100A6,SCN7A,SIX1,Slco1a4,SPARC,STAR,TDRD1,TGFA,TGFB1,TGFBI,TGM4,THBS2,Tlr12,TOP2A,TP63,TSHZ3,WNT4,WNT5A | 1690 (22) |
| NOX4 | -1.50e+00 | enzyme | Inhibited | -3.86e+00 | NA | 0.0e+00 | ACTA1,ACTA2,BCL2L1,BCL2L11,Ccl2,CD44,CDH1,CDKN1A,COL1A1,COX4I1,CYBA,CYBB,FN1,GCLC,HAS2,HIF1A,ICAM1,KIT,MMP2,NCF1,NCF2,NFE2L2,NOX4,RHOA,SERPINE1,SLC2A1,TGFA,VIM | 1559 (20) |
| IL21 | NA | cytokine | Inhibited | -3.87e+00 | NA | 0.0e+00 | ARG1,BATF,BCL2L1,BCL2L11,BCL6,CASP1,CASP3,CCL24,CCND2,CCRL2,CD1D,CD244,CD28,CD86,CDKN1A,CXCL10,CXCL13,CXCR5,DPP4,EGR1,FCER1G,FCGR2B,FGL2,FOXP3,GBP5,GZMB,HERC6,HIF1A,HLX,ID2,IFI16,IFIT1,IL17A,IL18R1,IL2RA,IL2RB,IL4I1,IRF4,IRF5,ISG15,MKI67,MMP2,OASL,PRDM1,PTPRC,RSAD2,RUNX1,SGK1,SLFN13,SOCS1,SOCS3,TGFB1,TLR4,USP18 | 1258 (17) |
| CHROMR | NA | other | Inhibited | -3.87e+00 | NA | 0.0e+00 | ATP10D,BCL3,BUB1,CCR1,CD9,CDKN1A,CEBPD,CNP,CXCL10,CYP1B1,DDIT4,DHX58,DTX3L,DUSP5,EPSTI1,EXT1,GBP2,GBP4,GBP5,GCA,GCH1,HERC6,HPSE,IFI16,IFI44,IFI44L,IFIH1,IFIT1,IFITM3,IL1RN,IRF1,ISG15,MAFF,MAX,MOV10,MX1,NOD2,OAS3,OASL,P2RY6,PFKFB3,PIM3,PNPT1,PPM1K,RAB27A,RASSF4,RSAD2,RTP4,SERPINE1,SIRPA,SLC25A28,SP110,SSBP3,STAT1,TBX3,TDRD7,THBD,TIMP1,TNFAIP6,UBA7,USP18,VAMP5,VEGFC,ZC3HAV1 | NA |
| paraquat | NA | chemical toxicant | Inhibited | -3.87e+00 | NA | 0.0e+00 | ADGRE1,ANGPT2,BCL2L1,CACNA1E,CCL21,CEBPD,CEP290,COL1A1,CYBB,EDN1,ELN,FN1,GCLC,GSR,Gsta4,INHBA,KCNA2,KLF6,LAMC2,LAMP2,MBOAT2,Mt1,NFAT5,NFKBIB,NR4A1,PLTP,PTGS2,ROCK1,SFTPB,SNCA,STRBP,TGFB1,TIMP1 | 1306 (16) |
| fenamic acid | NA | chemical reagent | Inhibited | -3.89e+00 | NA | 0.0e+00 | A2M,A3GALT2,ADAMTS1,ANXA1,ANXA2,ASNS,Bex2/LOC100912195,BIRC3,CD44,CP,EMP3,FBLIM1,GCGR,GPNMB,IER3,ITGB4,LAMC2,MRC1,PLA1A,S100A10,S100A11,SPP1,TES,TIMP1,TMSB10/TMSB4X,Tpm1,TSPAN8,TUBB,VIM | NA |
| Jnk | NA | group | Inhibited | -3.89e+00 | NA | 0.0e+00 | A2M,ABCA1,ACTA2,ANXA5,APLN,BCL2L1,BCL2L11,BIRC3,BTG1,BTRC,CASP3,Ccl2,CCND1,CD44,CD83,CD86,CDH1,CDH2,CELF2,COL1A1,COL3A1,CXCL12,CXCR4,DUSP1,EDN1,EGR1,ETS1,F2RL1,F3,FBXO32,FLI1,FN1,GADD45A,GAP43,ICAM1,IGF1,IL17A,IL2RA,ITGA4,ITGB7,JUND,KLF6,MMP14,MMP2,MRC1,MRC2,NCF1,NFE2L2,NOX4,NR4A1,OCLN,PDGFB,PLAT,PON2,PPARD,PTGES,PTGS2,RARA,RARG,RXRA,SELE,SERPINE1,SNAI2,SOCS3,STRA6,TGFB1,TIMP1,TINAGL1,TNFRSF10A,TRPC3,TWIST1,VCAM1,VCAN,ZFP36 | 1332 (15) |
| HMG20A | 1.00e-01 | transcription regulator | Inhibited | -3.90e+00 | NA | 0.0e+00 | ACTG1,ATF3,ATP2A2,AXL,Cald1,CD44,CD9,CDH1,CSF1,CX3CL1,CXADR,CXCL10,DCN,DHCR7,ECM1,EDN1,ELN,ERRFI1,F3,FADS2,FGF2,FLNA,GADD45A,GCH1,IGFBP4,IL15RA,INHBA,ITGA2,ITGA5,LSS,MMP14,MVD,NNMT,OSMR,RTP4,SDC4,SEMA3B,SERPINE1,SLC7A1,SLIT3,SNAI1,SPHK1,TAGLN,TGFB1,THY1,TIMP1,TNFRSF11B,VCAM1,VCAN,VEGFC | 1239 (13) |
| G protein alpha i | NA | group | Inhibited | -3.91e+00 | bias | 0.0e+00 | ADAMTS1,ADAMTS9,ATF3,C15orf48,C1R,CEBPD,CMKLR1,CXCL10,F2R,FAM167A,FCGR2B,GBP2,GBP4,GBP5,GBP7,HLA-A,IFIH1,IFITM3,ISG15,KLF4,MAFF,NR4A3,Oasl2,RSAD2,SERPING1,SOCS3,SPHK1,STAR,TAGLN2,THBS1,TIMP1,TUBB6,USP18 | 1203 (17) |
| KMT2D | 4.60e-01 | transcription regulator | Inhibited | -3.92e+00 | NA | 0.0e+00 | ADGRG2,AP1S3,BTG3,CCDC138,CCDC91,CHST7,CKAP4,CNTLN,CSPG4,ECHDC2,ENO3,FAM117A,FBXL7,FHL1,GJB2,GLYCTK,GPRC5C,GPX7,GRHL1,HOPX,IKZF2,IRF1,IRF6,KCTD15,KLF4,LOXL1,MEOX1,METRNL,MYF5,MYOM3,NIPSNAP3A,NPR3,NT5DC1,PCDH7,POLE4,PPARG,PPIC,PPP2R2B,RAB38,REEP6,RELL1,RIMKLB,SFXN4,SH3BGRL2,SIX4,SMAD6,SMO,SORD,STBD1,TCF15,TMEM53,TNNC1,TNNT2,TOX3,TRPV2,WDR17,Zfp429 (includes others),ZNF761 | 1047 (13) |
| Pkc(s) | NA | group | Inhibited | -3.94e+00 | NA | 0.0e+00 | ABCA1,ACTA2,AHR,APLN,ATF3,BCL11B,BCL2L1,BCL2L11,BDNF,CCR5,CD36,CDKN1A,CLDN1,CNN1,COL1A1,COL3A1,CXCR4,CYBB,DBP,DUSP1,EDN1,EGR1,EGR2,F3,FGF2,FN1,GADD45A,GADD45B,GAP43,HIF1A,ID2,IRF6,IRS1,ITGA5,KLF6,MAD1L1,MAOB,MAPK3,MMP2,MSR1,MYOG,NOS1,NOTCH4,NOX4,NR4A1,NR4A2,NR4A3,PDIA4,PER1,PHLDA1,POU2F2,PPARG,PTGS2,RARA,RBL1,RGS2,SERPINE1,SLC6A9,SPP1,STAR,TAGLN,TGFB1,VCAM1 | 1401 (17) |
| PLG | -7.30e-01 | peptidase | Inhibited | -3.96e+00 | bias | 0.0e+00 | ADIPOQ,ARG1,BDNF,CAV1,CLIC4,COL1A1,COLEC12,CSF1,CYP2S1,EDN1,EDNRB,ELMO1,F3,FCGR2B,FYN,GULP1,IL1RL1,MRC1,PLA2G5,PRKAR2B,PRKCE,PTGS2,RAB7A,RAC2,RHOA,SERPINE1,SYK,TNFRSF11B | 1568 (20) |
| inosine | NA | chemical - endogenous mammalian | Inhibited | -3.97e+00 | NA | 0.0e+00 | A2M,AIF1,ALCAM,ANTXR2,ANXA1,ANXA2,ANXA5,C2,C3,CFB,CXCL13,DPP4,EIF4EBP1,EMP3,FTL,GAP43,GFAP,IFITM3,IRF1,L1CAM,LCP1,Mt1,PPP1R14B,SERPING1,TIMP1,TUBA1A,VIM | NA |
| SYVN1 | 9.00e-02 | transporter | Inhibited | -3.98e+00 | NA | 0.0e+00 | ABCC3,ABCC4,ACSL3,AHR,ATP1A1,AXL,BCAT1,BHLHE40,CCND1,CD44,CSPG4,CYP1B1,DAB2,DPYD,DUSP1,F3,GGCX,HLA-A,IFI44,IRAK2,ITGA3,ITGA6,ITGB4,L1CAM,LDHB,MYOF,NDFIP2,NFE2L2,OLR1,PFN1,PLD2,PLPP3,PNPLA2,PTPRJ,RPL18,SCARA3,SIRT2,SLC16A1,SLC1A5,SLC20A1,SLC27A3,SLC2A1,SLC35B2,SLC35C2,SLC39A10,SLCO4A1,TMEM106B,TRERF1,UNC13D,ZC3HAV1,ZNF281 | 1093 (7) |
| N6AMT1 | 8.10e-01 | enzyme | Inhibited | -3.99e+00 | bias | 0.0e+00 | ACSM3,ADRA2A,ALMS1,ANGPT2,APCDD1,BRCA2,BTG1,Casp12,CDCA7L,CDKN1A,CDO1,CENPF,CIT,CNN3,DACH1,DMPK,ERI2,ESPL1,FADS1,FAM171A1,FSTL1,HIRIP3,IFITM3,IRS1,LCP1,LGR5,MCM8,MKI67,MPP3,PDE3B,PRELP,PTPRO,RASSF4,SLC39A10,SMARCD3,SMO,SNX10,SOAT1,SORD,TBC1D9,TGIF2,TIFA,TMEM132A,VAV3,WDR90,ZBTB12,ZBTB38 | NA |
| NFKBIA | 5.90e-01 | transcription regulator | Inhibited | -3.99e+00 | NA | 0.0e+00 | A2M,ACKR3,ADAMTS5,ADGRE5,AMPD3,ANKRD1,AXL,BCL11A,BCL2A1,BCL2L1,BCL3,BIRC3,BTG2,BUB1B,C3,CASP8,Ccl2,CCL21,Ccl7,CCNA2,CCND1,CCND2,CCNE2,CCR1,CCR3,CD44,CD74,CD86,CDC25B,CDH1,CDH3,CDK2,CDKN1A,CEBPD,CHI3L1,COL2A1,COL3A1,COL5A2,CP,CRYAB,CSF1,CSK,CX3CL1,CXCL10,CXCL12,CXCR4,CYBA,CYP1B1,CYP7B1,DCN,DUSP6,ERAP1,ESM1,F3,FCGRT,FGF2,FHL2,FN1,FOXC2,FSCN1,GADD45A,GADD45B,GADD45G,GBP2,GCH1,GM2A,GPR176,GPX3,GRK5,GZMB,HIF1A,HLA-A,HLA-DQA1,HOXB5,HPSE,ICAM1,IER3,IFI16,IGFBP6,IL15RA,IL1RN,IL2RA,IL33,IRF1,ISG15,ITGA2,ITGA3,KCNH2,KLF5,LGR5,LIMA1,LITAF,MATK,MMP14,MMP15,MR1,Mt1,MYOD1,NFKBIA,NFKBIB,NID1,NINJ1,NOD2,NR4A1,NRK,OGN,PARK7,PCDH7,PDLIM1,PEA15,PIK3R1,PLAT,PMEPA1,PTGES,PTGS2,PTP4A2,PTPRZ1,PTX3,RGS4,ROCK1,RPS18,RPS2,Rtp3,SDC1,SDC4,SELE,SEMA3C,SEMA3F,SFRP1,SGK1,SLC16A2,Slfn2,SOAT1,SOCS3,TCEAL9,TFCP2L1,TGFB1,TGFB1I1,TIMP1,TLR2,TLR4,TMEM176B,TNC,TNFAIP2,TNFAIP8,TNFRSF10A,TNFRSF11B,TNFRSF1B,TRADD,TWIST1,Ubb,UBE3A,VCAM1,VEGFC,Zfp68,ZNF638 | 1364 (14) |
| aldosterone | NA | chemical - endogenous mammalian | Inhibited | -3.99e+00 | NA | 0.0e+00 | ACTA1,ACTA2,ADAMTS1,ADIPOQ,APLN,AQP4,ATP1A1,ATP1B1,ATP6V0A4,BDNF,BGN,BMP4,CACNA1G,Ccl2,COL1A1,COL3A1,CYBA,CYBB,DCN,DUSP1,EDN1,EGR1,ELN,EMB,FKBP5,FN1,HAS2,ICAM1,IKBKB,IL16,IP6K3,IRS1,IRS2,KDR,LOX,LPL,MMP2,NCF1,NCF2,NFKBIA,NOX1,OLR1,PER1,PHLDA1,PPARG,PTGS2,RGS2,RUNX2,SCNN1G,SERPINE1,SGK1,SLC9A1,SPP1,TGFB1,TIMP1,Tnxb,VCAM1,VIM,WNK1,ZBTB16 | 1384 (17) |
| bromodeoxyuridine | NA | chemical drug | Inhibited | -4.00e+00 | bias | 0.0e+00 | BMP3,CSF1,CXCL10,F3,IFI16,IFI44,IFIH1,IFIT1,IGFBP4,IL7,INHBA,IRF1,IRF4,ISG15,MX1,SERPINE1,SP110,STAT1,TGFA,TGFBI | 1461 (18) |
| NFkB (family) | NA | group | Inhibited | -4.00e+00 | NA | 0.0e+00 | BCL2L1,CASP1,CASP3,CCND1,CXCL10,CXCL12,DRAM1,FN1,IL1R1,IL33,IRF1,JAG1,LPL,MMP2,NCAM1,NLRP3,PLAT,PLP1,PTGS2,SELE,SNAI2,TIMP1,VCAM1 | 1061 (20) |
| kainic acid | NA | chemical toxicant | Inhibited | -4.02e+00 | NA | 0.0e+00 | ATF3,BCL2L1,BDNF,BMP4,BTG2,CASP3,Ccl2,CCND1,CD200,CD44,CDH1,CIART,CNR1,CREM,CSF1R,CSRNP1,CTSE,DAB2,DUSP1,EGF,EGR1,EGR2,EGR3,ERRFI1,FGF10,FGF2,FGF9,FN1,GADD45B,GAP43,GFAP,GFRA1,GRIA2,GRIK4,HDC,HOMER1,IGF1,JUND,KCNQ2,KDR,LEF1,LMO1,LMO2,MMP2,NCAM1,NFIL3,NR4A1,NR4A2,NTRK2,PENK,PER1,PIM3,PLAT,PNMT,PTGER3,PTGES,PTGS2,RELN,RET,RGS2,RGS4,SDC1,SIX1,SLC16A1,SLC39A4,SPP1,SYP,Tcf7,TIMP1,TIPARP | 1193 (22) |
| Hbb-b2 | NA | other | Inhibited | -4.03e+00 | bias | 0.0e+00 | BCL2L11,Ccl2,Ccl7,CCR5,CD44,CD74,CIITA,CMTM3,CXCL10,CXCR5,CYBA,CYBB,FN1,FTL,IL10RA,IL16,IL2RB,IL2RG,LY86,NCF2,SERPINF2,TLR2 | 691 (7) |
| hydrogen peroxide | NA | chemical - endogenous mammalian | Inhibited | -4.03e+00 | NA | 0.0e+00 | ACTA2,ADAM17,ADIPOQ,AEN,ALOX5,ANKRA2,ANKRD1,ANXA1,ANXA2,ATF3,ATP6V1A,ATXN7L3B,BCL2A1,BCL2L1,BCL2L11,BCL9,BIRC3,BTG2,BTRC,BUB1,BUB1B,C1QTNF9B,C4BPA,CASP1,CASP3,CAV1,Ccl2,Ccl7,CCNA2,CCND1,CCR5,CD36,CD86,CDC34,CDH1,CDK2,CDKN1A,CDKN2C,CNR1,COL1A1,COL3A1,CRYAB,CSF1,CSF3R,CTSS,CUX1,CXCR4,DDAH2,DDIT4,DHCR7,DNAJB1,DUSP1,DUSP10,EDN1,EEF1A1,EGR1,ELN,ENC1,ENG,ETS1,EZH2,EZR,F2RL1,FBXO32,FGF2,FN1,FOXO3,FZD2,GADD45A,GADD45B,GCLC,GFPT2,GLI1,GLRX,Gsta4,GZMB,HDC,HIF1A,HLA-DRA,HRAS,ICAM1,IER5,IL10RB,IL2RA,IRS1,ISCU,ITGA2,ITGA3,ITGA6,ITGB3,KDR,KIT,KITLG,KLF4,LEF1,LTB4R,MAFA,MAP1LC3A,MAPK14,MB,MDK,mir-143,MITF,MMP2,MSMO1,MSR1,MYF5,NEK1,NFE2L2,NFIL3,NOS1,NOX1,NR4A1,OAZ2,PARK7,PDGFB,PDGFRA,PDIA4,Pmaip1,PPARG,PPARGC1B,PRDX1,PRKAB1,PRKCI,PSTPIP2,PTGS2,PTN,PTP4A2,PTX3,RAB27A,REL,RTN3,RUNX2,SELENOP,SERPINE1,SERPINH1,SESN1,SFRP2,SFTPB,SGK1,SLC20A1,SNAI1,SNAI2,SPARC,SPP1,STAR,STMN1,TAGLN,TGFB1,TLR4,TRPC3,TRPC6,TWIST1,UACA,UHRF1,VCAM1,VIM,WNK1,WNT4,WNT5A,YWHAQ | 1579 (18) |
| sodium chloride | NA | chemical - endogenous mammalian | Inhibited | -4.03e+00 | NA | 0.0e+00 | ACTA2,ADRA2A,APLNR,CALB1,CASP3,Ccl2,COL1A1,COL3A1,CRP,CYBA,CYBB,DDIT4,EDN1,FN1,HIF1A,ICAM1,NFAT5,NOS1,NOX4,NPR1,PTGES,PTGS2,SLC9A1,SPP1,TGFB1,VCAM1,VWF | 1300 (16) |
| CpG oligonucleotide | NA | chemical drug | Inhibited | -4.04e+00 | NA | 1.0e-02 | ABCA1,AHR,BCL2A1,C2,C5AR1,CA9,Ccl2,Ccl7,CCR1,CD34,CD36,CD83,CD86,CXCL10,DUSP1,EGR1,ELOVL5,FCGR2B,FCGRT,ICAM1,IL2RA,IL33,INPP5D,ISG15,LYN,MSR1,NOTCH2,OAS3,Oasl2,OLR1,PHGDH,PRKCD,PTGES,PTGS2,RASSF4,SAMSN1,SDC1,SERPINE1,SLC1A5,SYK,THBS1,TLR2 | NA |
| gentamicin C | NA | chemical drug | Inhibited | -4.04e+00 | NA | 0.0e+00 | A2M,A3GALT2,ADAMTS1,ANXA1,ANXA2,ASNS,Bex2/LOC100912195,BIRC3,CD44,CP,EMP3,FBLIM1,GCGR,GPNMB,IER3,LAMC2,MRC1,PLA1A,S100A10,S100A11,SPP1,TES,TIMP1,TMSB10/TMSB4X,Tpm1,TUBB,VIM | NA |
| RIPK2 | -1.22e+00 | kinase | Inhibited | -4.05e+00 | NA | 0.0e+00 | ABCA1,ACADL,ACSL1,CARD6,Ccl2,CD36,CD86,CXCL10,DHX58,FABP1,GBP4,Ggta1,ICAM1,IFI44,IFI44L,IFIH1,IFIT1,IKBKE,IL17A,IL33,ISG15,MAP3K6,MARCKSL1,MX1,MYCN,NFKBIA,NINJ1,OAS3,OASL,PNPLA2,PPARD,PTGES,RALGDS,RASGRP1,RSAD2,SELE,SLC27A1,SREBF1,STAT1,TNFAIP2,TNFAIP6,TRIM69,USP18,VCAM1 | 1299 (15) |
| Ifn | NA | group | Inhibited | -4.05e+00 | NA | 0.0e+00 | ADAMTS1,B2M,BCL6,CASP8,CD44,CD83,CD86,CFH,CXCL10,DHX58,EDN1,HGF,HIF1A,HLA-A,ICAM1,IFI16,IFIH1,IFIT1,IFITM3,IGF1,IL10RA,IL15RA,IL17A,IL1R1,IL33,IL7,IRF1,IRF3,IRF8,ISG15,ITGA4,MAVS,MX1,NTRK2,OAS3,OASL,PTAFR,PTPRJ,RSAD2,SERPINE1,SOCS1,SPP1,STAR,STAT1,TLR2,TLR5,TLR7 | 810 (15) |
| TP53 | -2.00e-02 | transcription regulator | Inhibited | -4.05e+00 | NA | 0.0e+00 | A2M,ABCA1,ACADL,ACADS,ACER2,ACO2,ACOT11,ACSF2,ACSL1,ACSL3,ACTA2,ACTN4,ADAMTSL4,ADD3,ADGRB3,ADGRE5,ADRB2,AEN,AK1,AK4,AKAP12,ALDH18A1,ALDH1A1,ALDH1A3,ALDH9A1,ALDOA,ALOX15,ALOX5,ANK1,ANKRD1,ANTXR1,ANXA1,ANXA2,ANXA8/ANXA8L1,AP1B1,APOBEC1,ARAP2,ARG1,ARHGAP45,ARHGEF2,ARL6IP1,ASNS,ATF3,ATL3,ATP1A1,AXIN2,BAP1,BCAT1,BCL2A1,BCL2L1,BCL2L11,BCL3,BCL6B,BDKRB2,BDNF,BHLHE40,BIRC3,BMP1,BOP1,BRCA2,BTG1,BTG2,BTK,BUB1,BUB1B,C2,CA9,CALCRL,Cald1,Calm1 (includes others),CALU,CAMK2D,CAMLG,CARD11,CARHSP1,CASP1,CASP3,CASP8,CAV1,CAV2,CCDC80,Ccl2,CCNA2,CCND1,CCND2,CCNE2,CCS,CD36,CD44,CD47,CDC25B,CDC34,CDC42EP3,CDH1,CDH3,CDK2,CDKN1A,CEBPD,CELSR1,CELSR3,CENPF,CENPK,CEP170B,CERS6,CGREF1,CISD1,CITED2,CKM,CKMT1A/CKMT1B,CLIC4,CNN1,CNN3,COL13A1,COL14A1,COL18A1,COL1A1,COL2A1,COL3A1,COL5A2,COL7A1,COQ2,CORO1A,COX6A2,Cox8b,CP,Crip2,CRYAB,CSF1,CSF1R,CSF2RA,CSF3R,CSK,CSNK1D,CSRP1,CSTB,CSTF1,CTIF,CTSH,CTSK,CX3CL1,CXCL10,CXCL12,CXCR5,CYP26B1,CYSLTR1,DAPK1,DAPK3,DBP,DDIT4,DDIT4L,DDR1,DEK,DEPDC1B,DHCR7,DHRS9,DKK3,DLC1,DNAJB4,DNAJC12,DNM1,DPP4,DRAM1,DTX1,DUSP1,DUSP5,DUSP6,DYNLL1,E2F2,E2F5,E2F8,ECH1,ECM1,EDA2R,EDIL3,EDN1,EEF1A1,EGF,EGFL6,EGR1,EGR2,EGR3,EIF2AK3,ELF4,ENG,ENO2,ENO3,EPHX1,ERCC1,ESPL1,Esrra,ESRRB,ESRRG,ESYT1,EYA4,EZH2,EZR,F2R,F3,F5,FEN1,FGF2,FGFR1,FHL1,FHL2,FKBP5,FLRT2,FN1,FOXO1,FOXO3,FOXP3,FSTL1,FUBP1,FUCA1,FXN,FYN,FZD6,G0S2,G6PD,GADD45A,GADD45B,GADD45G,GAL3ST4,GAPDH,GAS7,GATA4,GATM,GDA,GLI1,GLI2,GLRX,GLUL,GNA13,GNAI1,GOLGA4,GPD1,GPI,GPM6A,GPR157,GPR160,GPR176,GPRC5C,GPX3,GSK3A,GSR,HAS2,HDAC9,HDC,HGF,HIC1,HIF1A,HIF1AN,HLA-DQA1,Hmgn2 (includes others),HRAS,HSP90AA1,HSPA1A/HSPA1B,HSPB7,HYAL1,ICAM1,ID2,IDH1,IDH3G,IER3,IER5,IFI16,IFI44,IFI44L,IFIH1,IFIT1,IGF1,IGFBP4,IGFBP5,IGFBP7,IKBIP,IL10RA,IL16,IL17RA,IL1RN,IL2RA,IL33,IL4I1,IL7,INHBA,IRAK2,IRF1,IRF5,IRF8,IRS1,Irs3,ISCU,ISG15,ITGA2,ITGA2B,ITGB4,ITGB7,JUND,KCNH2,KCNK3,KDR,KIF18A,KIF23,KIF24,KIT,KITLG,KLF4,KLF5,KLF6,KLHL21,KNTC1,LAMC2,LAMP2,LASP1,LDHB,LGR5,LIMA1,LMAN2,LOX,LPIN1,LRAT,LRRC17,LSS,LTB4R,LTBP1,LYPLA1,MAD1L1,MAN2A1,MAP1LC3A,MAP1LC3B,MAP2K2,MAP2K4,MAP4K1,MAPK3,MAPK4,MAPRE3,MB,MCM7,ME2,MEOX1,MET,MGST2,mir-133,mir-143,MKI67,MMP2,MPV17L,MPZL2,MRC1,MRPL18,MRPL2,MRPL34,MRPL38,MRPL46,MRPS25,MSRB1,MTHFD2,MTMR11,MVD,MVK,MX1,MYBL1,MYH10,MYH7,MYL2,MYL3,MYO10,MYO5A,MYOCD,MYOF,NCAPG,NCF1,NCK2,NCOR2,NDRG4,NECTIN3,NFAM1,NFATC2IP,NFKBIA,NINJ1,NLRC4,NOS1,NOTCH2,NOX4,NR0B2,NR2F1,NR4A3,NR5A1,NRAP,NRARP,NRP1,NTN1,NUDT5,OASL,OCLN,OMA1,OVOL2,PALLD,PARD6G,PARK7,PAWR,PCBP4,PCDH7,PDGFB,PDGFRA,PDIA5,PDK2,PDLIM1,PDRG1,PEA15,PFKFB1,PFKFB3,PFKFB4,PFN1,PGAM2,PHGDH,PHKG1,PHLDA1,PHLDB3,PIK3CG,PIK3R1,PIK3R3,PKM,PLK1,PLK2,PLOD2,PLTP,Pmaip1,PMEPA1,PMM1,POLA1,POLR2E,PPARD,PPARG,PPARGC1B,PPIC,PPM1A,PPP1R13B,PPP3CA,PPP5C,PRAG1,PRC1,PRDM1,PRKAB1,PRKAB2,PRKCB,PRKCE,PRKCZ,PRKD1,PROM1,PRRX2,PSMB1,PSMC1,PSTPIP2,PTCH1,PTGER1,PTGS2,PTN,PTP4A3,PTPN12,PTPN6,PTPRO,Ptprv,PYCARD,RAB8A,RAC2,RASSF2,RBBP4,RBL1,RHOA,RHOF,RNASE4,RND3,RPS16,RPS18,RPS3,RPS6KB1,RRAD,RSAD2,RUNX1,RUNX2,S100A4,S100B,SCN3B,SCTR,SELE,SELP,SEMA3C,SERPINB9,SERPINE1,SERPING1,SERPINH1,SESN1,SFRP1,SFRP2,SGK1,SH3BGRL2,SKP2,SLC16A1,SLC19A2,SLC26A7,SLC2A1,SLC2A9,SMAD6,SMAD7,SMC2,SNAI1,SNAI2,SNCA,SNX3,SPC25,SPHK1,SPN,SPP1,SREBF1,SRSF3,SSPN,ST14,STAG1,STAT1,STMN1,SULF2,TACC2,TAGLN2,TBX3,TBX5,TBXAS1,TCEA3,TCTN1,TFPI2,TGFA,TGFB1,TGFB1I1,TGFBI,THBD,THBS1,THBS2,THBS4,THY1,TIMM9,TIMP1,TINAGL1,TKT,TLR7,TMEM127,TMEM43,TMOD1,TMSB10/TMSB4X,TNC,TNFAIP2,TNFAIP8,TNFRSF10A,TNFRSF1B,TOP2A,TP53BP2,TP53I13,TP63,TPD52L1,Tpm1,TRIM67,TRPV1,TSKU,TTC28,TUBB,TUBB4A,TULP4,TWIST1,TXNRD3,TYMS,UBC,UBQLN2,UCP3,UGDH,UHRF1,UMPS,UNC5A,UNC5B,UQCR10,VANGL1,VASN,VCAN,VIM,VWCE,WEE1,WNT2,WNT4,WNT9A,XPO1,ZBTB5,ZEB2,ZFP36,ZFP36L1 | 1616 (17) |
| stallimycin | NA | biologic drug | Inhibited | -4.05e+00 | bias | 0.0e+00 | BMP3,CSF1,CXCL10,F3,IFI16,IFI44,IFIH1,IFIT1,IL7,INHBA,IRF1,IRF4,ISG15,MX1,SP110,STAT1,TGFA | 1235 (14) |
| cytokine | NA | group | Inhibited | -4.07e+00 | NA | 0.0e+00 | ADORA2A,ALOX5,AQP4,BCL2L1,BCL3,C5AR1,CCND1,CD86,CD93,CISH,CRP,CSF1,CX3CL1,DUSP1,EDN1,EGR1,F3,FGF2,FOXP3,GFAP,HIF1A,ICAM1,IL2RA,IRF1,ITGA6,LIPG,MMP2,NOS1,PLAT,PTGS2,RETN,RIPK2,S100A4,SELE,SELP,SERPINE1,SGK1,SLC2A1,SOCS1,SOCS3,SPARC,TEK,TIMP1,TLR2,TLR4,TNFAIP6,TNFRSF1B,VCAM1,VWF | 1637 (18) |
| FOXM1 | -4.40e-01 | transcription regulator | Inhibited | -4.08e+00 | NA | 0.0e+00 | ACTA2,ADAM17,ANXA1,AXIN2,BRCA2,BUB1B,CAMK2D,CASP3,CAV1,Ccl2,CCNA2,CCND1,CCND2,CCNE2,CD44,CDC25B,CDH1,CDH2,CDK2,CDKN1A,CENPF,CRP,CSF1,CTNNAL1,CXCL12,EZH2,FN1,FZD1,HEY2,IGF1,IKBKB,IL1RN,ITGA5,KDR,KIF23,LAMA4,LEF1,LOX,MCM8,MET,MKI67,MMP2,MYCN,MYOCD,PGK1,PLK1,PLK4,PRC1,PROM1,PTCH1,SFRP1,SFTPB,SKP2,SNAI1,SNAI2,STMN1,TOP2A,TWIST1,TWIST2,VCAN,VIM,ZEB2 | 1457 (19) |
| PI3K (complex) | NA | complex | Inhibited | -4.13e+00 | NA | 0.0e+00 | ABCA1,ABCC4,ADRB2,APLN,AQP7,ATF3,BCL2A1,BCL2L1,BCL2L11,BIRC3,CASP3,Ccl2,CCND1,CCND2,CCR1,CD44,CD86,CDH1,CDH2,CDK5R1,CDKN1A,COL1A1,CREB1,CXCL10,CXCR4,CYBB,DAPP1,DDIT4,DUSP1,ETS1,FBLN5,FBXO32,FLI1,FN1,FOXO1,FUT7,G6PD,GAP43,GCLC,GLI1,GLI2,HAS3,HIF1A,HIF1AN,HK1,ICAM1,IFIT1,IGF1,IL17A,IL1RN,IL33,INHA,ITGA6,ITGB2,KDR,LASP1,LEF1,LTBP2,MAFA,MAP2,MAP2K4,MITF,MMP14,MMP2,MRC1,MTHFD2,MYOD1,NFE2L2,NFKBIA,NOX1,NOX4,NR4A2,PIK3CG,PLA2G4A,PLA2G5,PRDM1,PRKAR2B,PRKCZ,PTGS2,PTPN12,Rcan1,RGS2,RND3,RPL23,SEMA6D,SERPINE1,SGK1,SLC12A4,SLC12A7,SLC26A3,SLC9A1,SNAI1,SOAT1,SOCS3,SPP1,SREBF1,STMN1,TAGLN,THBS1,TLR4,TNFRSF10A,TP63,UGCG,VCAM1 | 1310 (15) |
| IFNL1 | NA | cytokine | Inhibited | -4.14e+00 | bias | 0.0e+00 | ATF3,CD83,CHAC1,CXCL10,F2R,GBP5,HERC6,IFI44,IFI44L,IFIH1,IFIT1,IFITM3,ISG15,MLKL,MX1,OAS3,OASL,RSAD2,RTP4,SLC15A3,SP110,STAT1,TDRD7,TLR2,UBE2L6,USP18,ZC3HAV1 | 1230 (16) |
| salmonella minnesota R595 lipopolysaccharides | NA | chemical - endogenous non-mammalian | Inhibited | -4.14e+00 | bias | 0.0e+00 | ACSL1,ATP6V1E1,AXL,BCL3,C8orf44-SGK3/SGK3,Ccl2,Ccl6,Ccl7,CCRL2,CD83,CD86,CEBPD,CXCL10,CXCL13,EDNRB,EGR1,HLA-DQA1,HLA-DRA,ICAM1,IKBKE,IRF1,IRF8,ISG15,JAG1,LPAR1,MAFF,MDFIC,MET,MKI67,NFKBIA,OASL,PSTPIP2,PTGS2,PTPRJ,RSAD2,SERPINE1,SLFN13,Slfn2,SOCS3,TLR2,VCAM1 | 1288 (14) |
| PAX7 | -2.90e-01 | transcription regulator | Inhibited | -4.22e+00 | bias | 0.0e+00 | ABCA1,AHR,C1QTNF3,CAMK1D,CDH11,CDH2,CLDN3,CXCR4,DEPTOR,EMB,EYA4,F2RL1,FAM107B,FRK,GCH1,HMGN1,ID2,KCNK2,LIX1,MDFIC,MSLN,MYF5,MYO1D,OLFM1,PARM1,PDLIM4,PLAGL1,PPARG,RNF128,SEMA3E,SLC44A1,TRIM54 | NA |
| IL4 | NA | cytokine | Inhibited | -4.23e+00 | NA | 0.0e+00 | ABCA1,ABLIM1,ACP5,ACSL1,ACTA2,ACTG1,ADAM17,ADAM19,ADGRE1,ADORA2A,ADRM1,AHR,ALG3,ALOX12,ALOX15,ALOX5,ANKRD55,ANO1,ANXA1,ANXA2,ARG1,ARID5A,ARSB,ATP2A1,AUH,AUTS2,BACE2,BANF1,BATF,BCAT1,BCAT2,BCL11A,BCL2L1,BCL3,BCL6,BDNF,BHLHE40,BIN1,BOP1,BPGM,C15orf48,C3,C5AR1,CALCR,CAMK1D,CASP3,CBFB,Ccdc50,CCDC86,Ccl2,CCL24,Ccl6,Ccl7,CCND1,CCND2,CCR1,CCR3,CCR5,CCRL2,CD200,CD200R1,CD22,CD276,CD300LF,CD36,CD44,CD6,CD74,CD83,CD86,CDK2,CDK6,CDKN1A,CELF2,CHST3,CHST7,CIITA,CISH,CITED2,CKAP4,CLCN3,COBLL1,COL18A1,COL1A1,COL3A1,COL6A3,COX4I1,CPEB3,CSF1,CSF1R,CSF2RB,CSF3R,CST7,CSTB,CTSC,CTSK,CX3CL1,CXCL10,CXCL16,CXCR4,CXCR5,CYBB,CYSLTR1,CYTH1,DDAH1,DDHD1,DDIT4,DHX58,DNAJC12,DNASE1L3,DOCK10,DPP4,DUOX2,DUSP10,EGLN1,EGR2,EIF3G,ENTPD1,EPHB4,EPHX1,ESPL1,Esrra,EXT1,F13A1,F2R,F2RL1,F3,FAAH,FADS1,FAM162A,FCER1G,FCGR1A,FCGR2B,FCGR3A/FCGR3B,Fcrls,FKBP5,FLNA,FLRT2,FLT3LG,FN1,FOXP3,FSCN1,FUT7,GADD45B,GADD45G,GATM,GBE1,GBP2,GBP5,GBP7,GIPC2,GLIPR2,GNB4,GNPNAT1,GSR,HCK,HCLS1,HDC,HEXIM2,HGF,HLA-DQA1,HLA-DRA,HLX,HOMER2,HOPX,HRH1,HSPA1A/HSPA1B,ICAM1,IER3,IFI16,IFI44,IFI44L,IFIH1,IFIT1,IFITM3,IFNLR1,IGF1,IGFBP4,IL10RA,IL15RA,IL16,IL17A,IL18R1,IL1R1,IL1RL1,IL1RL2,IL1RN,IL2RA,IL2RB,IL2RG,IL33,IL4I1,IQCG,IRAK2,IRAK3,IRF1,IRF4,IRF5,IRF8,ISG15,ITGA1,ITGA2,ITGA4,ITGAE,ITGAL,ITGB2,ITGB3,ITGB7,ITPK1,JAG1,JAK3,JUND,KCNH2,KCNK1,KIT,KITLG,KLF3,KLF4,KLF6,KRT19,LACTB,LAMP2,LCP2,LDLRAD3,LEF1,LGALS1,LIPG,LMAN2,LPL,LSR,LTB4R,LY75,MAF,MAL,MAP3K10,MAPK3,MATK,MED11,METRNL,MKI67,MMP2,MMP28,MOV10,MRC1,MRPL13,MS4A2,MSR1,MVK,MYOD1,MYOF,MYOG,NAB2,NABP1,NEDD9,NFIL3,NFKBIA,NR4A3,NRP1,OAS3,OASL,OCLN,PAWR,PGK1,PGM1,PIK3C2B,PIK3R1,PKIB,PKM,PKP3,PLD1,PLOD2,PMP22,POLA1,POLG,POU2F2,PPARG,PPARGC1B,PPP5C,PRDM1,PREX1,PRKCD,PRKDC,PROS1,PRR3,PSMA6,PSTPIP1,PTGS2,PTPN7,RAB30,RASGEF1B,RASSF4,REEP6,RHOA,RIDA,RIPK3,RNF213,RNF5,RNPEP,RPUSD3,RRAD,S100A10,SAMSN1,Scd2,SDC1,SEC24A,SELE,SELP,SEMA4A,SEMA7A,SERPINB8,SERPINB9,SERPINE1,SHISA3,SIRPA,SKA1,SLC16A3,SLC25A25,Slc26a10,SLC2A1,SLC37A4,SOCS1,SOCS3,SORCS2,SPHK1,SPN,SPP1,SREBF1,ST14,ST6GAL1,STAT1,STAT5B,STAT6,SWAP70,SYK,SYMPK,Tcf7,TES,TGFB1,TGFBI,THBD,THY1,TIMP1,TINAGL1,TLE1,TLR2,TLR4,TMED5,TMEM176B,TNC,TNFAIP6,TNFRSF11B,TNFRSF4,TNFRSF8,TNFSF18,TNFSF8,TNIP2,TOP3B,TP63,TPBG,TPD52L2,TRPV2,TYRO3,USP18,VCAM1,VIM,VIPR2,VTCN1,VTI1A,WNT11,ZFP36,Zfp53,ZNF219,ZNF608,ZNF628 | 1391 (16) |
| IL33 | -2.00e+00 | cytokine | Inhibited | -4.24e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ADAMTS1,Adgre4,ALDH1A3,ALDOA,ARFGAP3,ARG1,ARHGAP30,ARHGAP9,ATP10A,ATP8B4,AXL,BATF,BCL2A1,BCL2L1,BCL2L11,BCL3,BIRC3,CASP1,Ccl2,Ccl7,CCND1,CCR1,CD200R1,CD28,CD36,CD53,CD83,CD86,CDK5R1,CHST11,CISH,CLEC4A,Clec4a3,COL3A1,CREM,CSF2RB,CSF3R,CSTB,CX3CL1,CXCL10,CXCL16,DOCK2,EEF1E1,EGR2,EGR3,ELMO1,ENO2,ENTPD1,ETS1,FA2H,FAM162A,FAR1,FER1L6,FGD2,FGL2,FGR,FOXP3,FTL,G0S2,GADD45B,GNA13,GPR65,HACD3,HBA1/HBA2,HCAR2,HCK,HDC,HIF1A,HSPE1,ICAM1,ID2,IER3,IKBKE,IL10RA,IL17A,IL1RL1,IL1RN,IL2RA,IL2RB,IL2RG,IL33,IL4I1,IRAK3,IRF5,ITGA5,ITGB4,JAG1,KLC1,KLF4,LEPR,LGALS1,MDK,Milr1,MRPL54,MSR1,MYO15A,NABP1,NCF4,NFIL3,NFKBIA,NFKBIB,NHP2,NLRP3,NR4A1,NRP1,OCLN,P2RY1,PDGFB,PDLIM1,PEA15,PGK1,PLAT,POU2F2,PPARG,PRDM1,PRDX1,PREB,PRPF4B,PTPRC,RANBP1,RASGRP1,RASSF4,REL,RGS10,RIPK2,SCAND1,SDC4,SERPINB9,SERPINE1,SIGLEC8,SLC7A8,SMAD6,SOCS3,STX11,TGFA,TGFB1,THEMIS2,TIFAB,TIMP1,TLR2,TNFAIP2,TNFRSF1B,TNFRSF25,TNFRSF4,TP63,TPBG,TPH1,TRPV2,TUBB6,VEGFC,ZEB2,ZFP36 | 1204 (18) |
| IHH | 3.70e-01 | enzyme | Inhibited | -4.25e+00 | NA | 0.0e+00 | ALDH1A1,BMP4,CA9,CBFB,Ccl2,CCND1,CHST11,CMA1,COL11A1,COL27A1,COL2A1,CXCL10,DHH,EDIL3,FBP2,FZD1,GLI1,GPC3,GPR34,KDR,LPAR4,MET,MRC1,NR2F2,PDK4,PLIN4,PPP1R1A,PTCH1,PTGFR,RUNX2,SHOX2,SKA1,SMO,SPP1,TAL1,TMEM67,TNFRSF11B | 77 (4) |
| YAP1 | NA | transcription regulator | Inhibited | -4.26e+00 | NA | 0.0e+00 | ACSF2,ACTA2,ACTG1,ADAMTS1,ADCY7,AMPD1,ANK1,ANKRD1,AP1AR,ARG1,BCL2L1,BCL2L11,BIN1,BRI3,C19orf53,CASP3,CASP8,CCDC80,Ccl2,CCNA2,CCND1,CCRL2,CD36,CD44,CDC42EP3,CDH1,CDH2,CDK2,CDK6,CDKN1A,CEP131,CIT,COL1A1,COL5A1,COL7A1,CSF1,CXCL12,CXCR4,CYTIP,DAB2,DCN,DDAH1,DIAPH3,DNASE1L3,DTX2,E2F7,EDN1,EGR1,EGR2,EMCN,FBXO32,FGF1,FLNA,FN1,GAB1,GADD45A,GNG2,GREM1,Hmgn2 (includes others),ICAM1,ID2,IFIT1,IGFBP4,INHBA,INPP5D,ITGA1,ITGA5,ITGB2,KCNH2,KDM3A,KIF23,KITLG,KLF5,LGR5,LIMCH1,LOX,LOXL2,LPL,LY75,MAP1B,MC2R,MMP14,MMP2,MRC1,MSLN,MYF5,MYH3,MYH7,MYOG,NDUFB3,NFKBIA,NLRC4,NR5A1,NUAK2,OCLN,PANX1,PDE3B,PDGFB,PDK4,PKM,PLK1,PLOD2,PMEPA1,POLA1,PPP1R3B,PRKDC,PTGFR,PTGS2,RANBP1,RASSF4,RPL14,RPL17,RPL18,RPL22,RPL23,RPL28,RPL35,RPL37A,RPL6,RPL7L1,RPS10,RPS11,RPS15,RPS15A,RPS16,RPS18,RPS2,RPS24,RPS3,SART3,SERPINE1,SGK1,SKP2,SMAD6,SMAD7,SNAI2,ST6GAL1,STAR,STAT1,SYK,TAGLN,TGFB1,TGFB1I1,THBS1,THBS3,TIMP1,TNIP2,TOP2A,TP63,TRADD,TRIM63,TUBB,TYMS,UACA,UBE3A,UCK1,UHRF1,VCAM1,VIM,ZBTB34,ZNF322 | 1445 (22) |
| Brd4 | NA | kinase | Inhibited | -4.28e+00 | NA | 0.0e+00 | ACTA2,ADAM19,ALDOA,ATP8B4,C1R,CCR5,CDH1,CFB,COL1A1,COL3A1,COL5A2,COL6A3,COL8A1,EDNRB,G6PD,GPI,GPR183,H2-T24,HBA1/HBA2,HGF,ITGA6,ITGAE,ITGAL,ITGB7,KDR,KIT,KLF4,LOX,LOXL2,LY86,NEK6,PGK1,PKM,PLAT,POLE4,PPARGC1B,RASSF2,SELE,SLC25A22,SLC25A25,SLC25A44,SLC2A1,TAGLN,TIMP1,TLR4,TLR8,TNFSF8 | 1384 (18) |
| CSF1 | -1.26e+00 | cytokine | Inhibited | -4.32e+00 | NA | 0.0e+00 | ABCA1,ABCA9,ACP5,ADGRE1,ADGRE5,ALOX5,APOBEC1,ARG1,AXL,BCL2L1,BCL2L11,BHLHE40,C5AR1,CALCR,Ccl2,Ccl7,CCND1,CCND2,CCR1,CCR5,CD36,CD74,CD83,CD86,CD9,CDK2,CDKN1A,COL23A1,CREB1,CSF1,CSF1R,CTSH,CTSK,CX3CR1,CXCL10,CYBB,DHCR7,DOK2,DUSP1,DUSP5,EBP,EGR1,EGR2,EGR3,F2R,F2RL1,FCER1G,FCGR3A/FCGR3B,FCGRT,FHL2,FN1,FOLR2,GAS7,GPI,GPNMB,GPR34,GPR68,HIF1A,HLA-A,ID2,IFIT1,IGF1,IKBKE,IL10RA,IL18BP,IL1RL1,IL2RB,IRF1,IRF4,IRF5,IRF8,ITGA4,ITGA5,ITGB3,LPL,LSS,MRC1,MSMO1,MSR1,MVD,MVK,MX1,Naip1 (includes others),NCF2,OAS3,P2RY12,PFKFB3,PKM,PPARG,PTPRC,PTPRJ,PTPRZ1,RHOA,RUNX1,RXRA,SFRP1,SLC16A3,SLC1A5,SLC2A1,SLC37A2,SLCO2B1,SOCS1,SPARC,SPP1,STAT1,STX3,TAB3,TGFB1,THBS1,TLR2,TLR5,TNFRSF1B,VCAM1,ZNF705A | 1264 (16) |
| hexachlorobenzene | NA | chemical toxicant | Inhibited | -4.32e+00 | NA | 0.0e+00 | A2M,A3GALT2,ANXA1,ANXA2,ASNS,Bex2/LOC100912195,CD44,CP,EMP3,FBLIM1,GCGR,GPNMB,IER3,ITGB4,LAMC2,MMP2,MRC1,S100A10,S100A11,SPP1,TES,TIMP1,TMSB10/TMSB4X,Tpm1,TSPAN8,VIM | 1286 (14) |
| MYD88 | -6.00e-02 | other | Inhibited | -4.32e+00 | NA | 0.0e+00 | ACSL1,ALDH1A1,AOX1,ARG1,ATP6V1E1,AXIN2,BAMBI,BATF,BCL3,BCL6,C3,Ccl2,CCRL2,CD200,CD200R1,CD44,CD83,CD86,CEBPD,CISH,CLIC4,CTSK,CXCL10,CXCL12,CXCL13,DUSP1,EDNRB,EGR1,FANCB,FBXO32,FCER1G,FGF10,FOXO1,FOXP3,GZMB,HCK,HDC,HIF1A,HLA-A,ICAM1,IGF1,IGFBP5,IKBKE,IL17A,IL18R1,IL1RN,IL7,INHBA,INPP5D,IRAK2,IRAK3,IRF1,IRF8,ISG15,ITGA4,ITGB7,JAG1,LGR5,LPAR1,MAFF,MET,MKI67,MMP14,MMP2,MRC1,MSR1,MYH7,NFKBIA,NLRP3,NOD2,NOX1,NOX4,OASL,OLR1,PLA2G4A,POLA2,POLE3,PSMA4,PSTPIP2,PTGES,PTGS2,RSAD2,RUNX2,SELE,SERPINE1,SLC16A3,SLCO3A1,SOCS1,SOCS3,SPP1,Tcf7,TGFB1,TIMP1,TLR2,TRIM63,TYMS,USP18,VCAM1,XPA,ZC3H12C | 1201 (14) |
| bleomycin | NA | biologic drug | Inhibited | -4.34e+00 | NA | 0.0e+00 | ACKR3,ACTA2,ANGPT2,ARG1,ARRDC3,ATF3,B3GNT7,BCL2L1,BHLHE40,BMP1,BMP4,C3,CASP3,Ccl2,CCND2,CCR1,CCR5,CD300LF,CD86,CDC25B,CDH11,CDKN1A,CHI3L1,CIART,COL1A1,COL3A1,CSF2RB,CTSE,CTSK,CTSS,CXCL10,CXCL12,CXCR4,DCN,DUSP5,E2F7,ELN,F2R,FABP1,FAP,FGFR1,FN1,FRZB,FZD1,FZD6,GAB1,GADD45A,Gimap9,GPR34,HIF1A,HSP90AA1,ICAM1,IGF1,IL17A,IRS2,ITGA1,JAG1,KITLG,KLF15,KLF4,KLHL42,LOX,LTBP1,LTBP2,MAFF,MAP1LC3B,MAP3K6,MID1,MMP14,MMP2,MRC1,MSN,MYCT1,NDN,NR4A1,OASL,PLA1A,PLAT,PLK2,PPTC7,PTX3,RGCC,RTP4,S100A4,SDC4,SEMA7A,SERPINE1,SFRP1,SFRP2,SIRPA,SNAI1,SOCS3,SPHK1,SPP1,TBC1D9,TGFB1,TGIF2,THBS1,THBS4,TIMP1,TINAGL1,Tlr13,TLR2,TMPRSS2,TNFRSF10A,TNNC1,TP63,TWIST1,UHRF1,VWF,WNT5A | 1546 (15) |
| TWIST1 | -2.12e+00 | transcription regulator | Inhibited | -4.35e+00 | NA | 0.0e+00 | ACTA2,ADAMTS1,ALCAM,ALDH1A1,APOD,ARG1,AXL,BCL2L11,C3,CASP3,CBX2,Ccl2,CD44,CDH1,CDH2,CDKN1A,CELSR1,CHI3L1,COL1A1,COL2A1,CXCL12,DCN,DDR2,DKK3,DNM1,DPYSL3,EGFL6,EMP3,ENPP3,ETS1,EZH2,FBN2,FCGBP,FGF10,FIBIN,FMOD,FN1,FOXC2,FOXO1,FREM2,GLI1,HEG1,HOXD10,IGFBP4,IGFBP5,ITGA8,ITGB3,KIT,LRG1,MET,MME,MMP2,MRC1,MRC2,MXRA8,NCAM1,OLFML3,PAM,PAMR1,PCDH18,PCOLCE,PDGFRA,PRKD1,PROM1,PRRX2,PTPRZ1,PXDN,RHOA,RUNX2,S100A4,SEMA5A,SNAI1,SNAI2,SPHK1,SPP1,ST8SIA2,TGFB1,TGFBI,THBS2,UNC5B,VCAN,VIM,ZEB2 | 1414 (22) |
| GDF2 | NA | growth factor | Inhibited | -4.37e+00 | NA | 0.0e+00 | ACTC1,ATP1A1,BAMBI,CAV1,CDCA7L,CDH11,CDH6,COL1A1,CRYAB,CXCL12,CXCR4,DLK1,EDN1,ELOVL1,EMB,ENG,FMOD,FOXC2,GADD45B,GATA4,HAS2,HEY2,HIF1A,HTRA3,ICAM1,ID2,IGF1,IGFBP5,JAG1,KIT,MAP2,NFKBIA,NINJ1,NRCAM,NRP1,NTS,PIM3,PROX1,SELE,SEMA3B,SEMA3C,SERPINB9,SERPINF1,SHISA3,SLCO2A1,SMAD6,SMAD7,SPP1,SREBF1,TLR4,UNC5B,VAT1L,VCAM1 | 1360 (22) |
| cisplatin | NA | chemical drug | Inhibited | -4.41e+00 | NA | 0.0e+00 | A2M,A3GALT2,ABCC3,ABCC4,ACTA2,ADAMTS1,ADGRE1,ADRM1,AHNAK2,ALDH1A1,ALDH1A3,ANK1,ANKRD1,ANPEP,ANXA1,ANXA2,ANXA5,ASNS,ASRGL1,ATF3,BAG5,BCL2A1,BCL2L1,BCL2L11,BCL2L12,Bex2/LOC100912195,BIRC3,BLOC1S2,BMP4,BTG2,C3,CARD6,CASP1,Casp12,CASP3,CASP8,CAV1,Ccl2,CCND1,CCR1,CCR5,CD44,CD53,CDC14B,CDC25B,CDH1,CDKN1A,CDO1,CHKA,CHST7,CLDN19,COL1A1,CP,CREB5,CROCC,CSF1,CXCL10,CXCL14,CYBB,DDIT4,DEPDC1B,DRAM1,DUS3L,DUSP1,DUSP6,E2F7,ECM1,EDN1,EEF2K,EGF,EGR1,EMP3,EPHX1,EPS8L2,ERBB3,ERCC1,EZH2,F3,FADS3,FAM117A,FAXDC2,FBLIM1,FEZ1,FLRT3,FN1,FXN,FYN,G0S2,G6PD,GADD45A,GAMT,GAP43,GCGR,GPNMB,GRIA2,Gsta4,HAP1,HBA1/HBA2,HDAC9,HIC1,HIF1A,HK1,HYAL1,ICAM1,ID2,IER3,IER5,IFIH1,IL10RA,INHBA,INPP5D,ISCU,ITGA6,ITGB4,JUND,KRT19,L1CAM,LAMC2,LBP,LDHB,LGR5,LPIN1,MAD1L1,MAML2,MAP1LC3B,MBD4,MET,MICALL2,mir-143,MMP14,MMP2,MRC1,Mt1,MX1,MYCN,NAV3,NCAM1,NCF1,NCF2,NEFL,NFKBIA,NINJ1,NMI,NOX1,NOX4,NR0B2,NTN4,OCLN,OMA1,PARD6G,PAWR,PBX3,PDE3B,PDE4A,PDK4,PEBP1,PEX6,PGM1,PHGDH,PLA1A,PLAT,PLK1,PLK2,PLK3,Pmaip1,PPIA,PRKAB1,PRKDC,PROM1,PTAFR,PTGES,PTGS2,PTPRO,RDM1,RGL1,RGN,ROCK1,RPS16,RUNX1,RXRA,S100A10,S100A11,SEMA7A,SERPINE1,SESN1,SLC2A1,SLC7A6,SMAD6,SMOX,SOCS3,SOX6,SPARC,SPEG,SPP1,ST6GAL1,STMN1,SULF2,TES,TGFB1,THBS1,TIMP1,TLR4,TM7SF3,TMSB10/TMSB4X,TNC,TNFAIP8,TNFRSF1B,TNK2,TOP2A,TP63,Tpm1,TRPV1,TSPAN2,TSPAN8,TUBB,TWIST1,TYMS,UHRF1,UNC13D,USP6NL,VCAM1,VIM,VTCN1,WDR4,WEE1,WNT4,ZNF219 | 1620 (18) |
| IL1A | NA | cytokine | Inhibited | -4.42e+00 | NA | 0.0e+00 | ADAMTS1,ADAMTS5,ADORA2A,ALDH1A1,ALDH1A3,APOD,ASIC2,ATF3,BCL2L1,BCL3,BIRC3,C3,Ccl2,CD44,CD83,CD86,CDKN1A,CSF1,CTSK,CXCL10,CXCL12,DPP4,F2RL1,F2RL3,FAM89B,FGF2,FGFR1,GCH1,GNB4,HDC,ICAM1,IER3,IGF1,IGFBP5,IL17A,IL1RN,IL2RA,INHBA,IRF1,ITGA5,ITGB3,JAM2,KIT,KITLG,LOX,MMP14,MMP2,NFKBIA,NR2F2,P2RY6,PDGFB,PLA2G4A,PPARG,PTGES,PTGS2,PTX3,S100A10,SELE,SERPINE1,SPARC,SPP1,TERF2IP,TGFB1,TIMP1,TLR2,TNFRSF11B,TOX3,VCAM1,VEGFC,VIM,WNT5A | 1213 (14) |
| pyridostatin | NA | chemical reagent | Inhibited | -4.42e+00 | bias | 0.0e+00 | B2M,CCRL2,CXCL10,DHX58,GBP4,HERC6,IFI44,IFI44L,IFIH1,IFIT1,IFITM3,IRF1,ISG15,MOV10,MX1,NMI,OASL,PARP14,PARP9,RSAD2,RTP4,SLC25A28,SP110,TDRD7,UBA7,UBE2L6,USP18 | 1023 (14) |
| E. coli B5 lipopolysaccharide | NA | chemical - endogenous non-mammalian | Inhibited | -4.44e+00 | NA | 0.0e+00 | ACKR3,ADAMTS1,ADH1C,ADRB2,B2M,BCL3,BCL6,BHLHE40,BIRC3,Ccl2,CCL24,Ccl6,Ccl7,CCND1,CCR1,CCR5,CD44,CD83,CD86,CDK6,CDKN1A,CSF3R,CX3CL1,CX3CR1,CXCL10,CXCL13,CXCR4,CYBB,DUSP1,EEF1A1,ERRFI1,F3,FABP1,FOXP3,GBP2,GCLC,GNPNAT1,HLA-A,ICAM1,IFIT1,IL15RA,IL16,IL17A,IL17RA,IL1R1,IL2RA,IL7,INHBB,IRAK3,IRF1,ITGAL,MAT2A,MSN,NCF1,NCF2,NEDD4L,NFKBIA,NOD2,OASL,PHLDA1,PPIA,PRDM1,PRDM16,PTGS2,RDX,SDC1,SELE,SELENBP1,SELENOP,SERPINE1,SOCS3,SPP1,SUMO2,TGFB1,THBS1,TLR2,TLR4,TLR7,TPO | 1192 (14) |
| LDL | NA | complex | Inhibited | -4.45e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ATF3,ATP2A2,AXL,BCL2A1,BCL2L1,BCL2L11,C3,CASP1,CASP3,CASP8,Ccl2,Ccl7,CCND1,CD36,CDKN1A,CLIP2,CREM,CTSK,CX3CR1,CXCL10,CXCL13,CYBB,DUSP1,EDNRB,EGR1,EGR3,EMB,F3,FCGR1A,FCGR2B,G0S2,GCLC,GJA5,GNAI1,GPR183,HAS2,HAS3,HIF1A,ICAM1,IGF1,IGFBP4,IL10RA,IL17RA,IL1RN,IRAK3,ITGB3,LASP1,LIMS1,MKI67,MMP14,MMP2,MSR1,MX1,NCF1,NLRP3,NOX1,NR0B2,NR4A1,NR4A2,NR4A3,NRP1,OLR1,PANX1,PLAT,PPARG,PSMC5,PTAFR,PTGS2,PTPRF,RANBP1,RARA,RNASEH1,RND3,SELE,SELP,SERPINE1,SIPA1,SLC2A1,SOCS1,SOCS3,SPHK1,SREBF1,STAR,TGFB1,TLR2,TLR4,TNFAIP6,TNFAIP8L2,TRADD,VCAM1 | 1595 (15) |
| SMAD3 | 3.80e-01 | transcription regulator | Inhibited | -4.46e+00 | NA | 0.0e+00 | ACTA2,ACVR1C,ADAMTS1,ADAMTS2,ADAMTS5,AGPAT2,ANKRD1,ARHGAP24,ARHGAP27,AXIN2,BCL2L11,BGN,C3,Ccl2,CCND1,CCND2,CDH1,CDH11,CDH2,CDH6,CDKN1A,CHRDL1,CIITA,CKM,COL1A1,COL2A1,COL3A1,COL6A3,COL7A1,CRP,CXCL10,DAPK1,DEPTOR,EDN1,EGR1,ELN,ENG,ESM1,FBN1,FBN2,FCGR2B,FN1,FNDC5,FOXO1,FOXO3,FOXP3,GADD45B,GLI1,GLI2,GZMB,HAS2,HHEX,ID2,IL2RA,INHA,INPP5D,JAG1,JAM2,JUND,LAMA4,LGALS9B,LOX,LPAR1,LUM,MAX,MBOAT2,MMP19,MMP2,MSTN,MYOD1,NET1,NOX4,NR5A1,PC,PCOLCE,PCOLCE2,PCSK5,PDGFB,PMEPA1,PNMT,POLE4,PPARD,PTGS2,PTP4A3,PTX3,RUNX2,Scd2,SERPINE1,SFTPB,SMAD7,SNAI1,SNAI2,SPARC,SPHK1,SPON1,SPP1,STAR,TAGLN,TBX3,TGFA,TGFB1,THBS1,THBS2,THBS4,TIMP1,TNC,TWIST1,VCAN,VEGFC,VIM,ZEB2,ZFP36 | 1529 (18) |
| VEGFA | 4.40e-01 | growth factor | Inhibited | -4.47e+00 | NA | 0.0e+00 | ABHD5,ACSL1,ACTA2,ADAMTS1,AK4,ANGPT2,ANPEP,BATF,BCAT2,BCL2A1,BCL6B,BMP4,BTK,CASP3,CAV1,CBFB,Ccl2,CCND1,CCRL2,CD244,CD34,CD36,CD83,CD86,CDKN1A,CEACAM1,CITED2,CLIC4,COL1A1,COX6B1,CSTB,CTSS,CXCL10,CXCL12,CXCR4,DLL1,DUSP5,E2F2,EDN1,EGR1,EPHB4,ERAP1,ESM1,ETS1,ETV5,EXOC3L2,F3,FGF2,FGFR1,FN1,GRIA2,HIF1A,HK1,HLX,ICAM1,IGFBP4,IGFBP5,IKBKE,IL17A,INPP5D,ITGA1,ITGA2,ITGA4,ITGB3,KDR,ME2,MEOX2,MKI67,MMP15,MRPL23,MRPS12,MYCN,NDUFA1,NOTCH4,NR2F2,NR4A1,NR4A2,NRP1,OCLN,PDGFB,PIK3CG,PLAT,PLIN1,PLPP3,PNPLA2,PRPF6,PTGS2,RUNX1,RUNX2,SELE,SERPINE1,SFTPB,SLC25A6,SNAI2,SPARC,SPP1,STARD8,TAL1,TBC1D8,TEK,TFPI2,TGFB1,THBD,THBS1,TIMM13,TIMP1,TMSB10/TMSB4X,TNC,TRPC6,UNC5B,VCAM1 | 1099 (16) |
| tetrabromobisphenol A | NA | chemical toxicant | Inhibited | -4.49e+00 | bias | 0.0e+00 | COL12A1,COL16A1,COL1A1,COL3A1,COL5A1,EGF,ENG,GREM1,ITGA1,ITGA2,ITGA3,ITGB3,LOX,LTBP1,PDGFB,SERPINH1,SMAD6,SMAD7,SNAI1,STAT6,TGFB1,THBS1,THBS2,TIMP1 | 1321 (22) |
| aflatoxin B1 | NA | chemical - endogenous non-mammalian | Inhibited | -4.49e+00 | NA | 0.0e+00 | A2M,ABCC3,ACSL3,ACTA1,Akr1b10,ALDH1A1,AOX1,APBB3,BARD1,BRCA2,BUB1,CCNA2,CCNE2,CDKN1A,CDKN2C,CENPF,CLDN1,CNKSR1,COL14A1,CRYAB,CX3CL1,CXCL13,DAB1,DBP,DCN,DDIT4L,DDR1,DMBT1,ECT2,EDA2R,EDNRB,EGF,ERMP1,ESPL1,EZR,FADS1,FADS2,FAM83F,FGF1,GCGR,GCLC,GNAI1,GORAB,GRIA2,GSR,GULP1,HLA-A,HLA-DQA1,HLTF,IGFBP7,INHBA,IQGAP3,IRS2,ITGA5,ITGB4,KIF11,KIF23,KLF5,KNL1,KNTC1,LAMC2,LEPR,LPL,MAP1B,MCM8,MET,MGAT3,MME,MMP2,MYBL1,NCF2,NCK2,NEFL,NRCAM,PHGDH,PLK1,PPIC,PRC1,PRKAB1,PRRG4,RAP1GAP,RBL1,RGS2,SEMA3B,SERPINB9,SFRP1,SMC2,SORT1,SPARC,SPC25,SPP1,STAR,STMN1,SULF2,TACC3,TOP2A,TRPV1,TSPAN8,TYMS,UGDH,WFIKKN2,WNT4 | 1144 (10) |
| Akt | NA | group | Inhibited | -4.53e+00 | NA | 0.0e+00 | A2M,ACTA2,ADIPOQ,ANKRD1,ANKRD2,B3GALNT2,B3GALT6,BCL2A1,BCL2L1,BCL2L11,BCL6,BHLHE40,BTG2,Ccl2,CCND1,CCND2,CD36,CD44,CDH1,CDH2,CDKN1A,CHST3,COL2A1,COL3A1,COQ7,COX4I1,CP,CXCL10,CXCL12,CXCR4,E2F2,EGR2,ERAP1,ERBB3,EXT1,EZH2,F3,FBXO32,FKBP5,FN1,FOXO1,FOXO3,FOXP3,GALNT10,GCNT2,GGT5,GHITM,GLI1,GLI2,GSR,GXYLT2,HIF1A,HIF3A,IER3,IGF1,IL17A,IL1R1,IL2RB,KCNA5,L1CAM,LAMA3,LAMC2,LEF1,LPL,MAN2A1,MAP2,Mbp,mir-133,MME,MMP14,MMP2,MSI1,MSLN,MYCN,NCEH1,NDUFV1,NET1,NFE2L2,NFIL3,NFKBIA,NOS1,NOTCH2,NOX4,NR0B2,NRP2,PDK4,PEA15,PLA2G4A,PPARD,PPARG,PRDM16,PTAFR,PTGS2,PTN,PTPRF,PTX3,RDH10,RPL6,RPS16,RPS2,RUNX2,SEMA6D,SERPINE1,SGK1,SKP2,SLC2A1,SNAI1,SNAI2,SOCS3,SPP1,ST3GAL1,ST3GAL6,STT3A,SUSD5,THBS1,THBS2,TIPARP,TLR2,TMEM106B,TMEM259,TNC,TRADD,TYMS,UCP3,UGT8,UTRN,VCAM1,VCAN,VIM,VTCN1 | 1278 (15) |
| OSM | 4.90e-01 | cytokine | Inhibited | -4.57e+00 | NA | 0.0e+00 | A2M,ABCA1,ABCC3,ABCC4,ABCC5,ABCC8,ABCG1,ACKR2,ACSL3,ACSL5,ACTA2,ADAM17,ADAMTS1,ADAMTS5,ADGRG6,AHR,ALOX12,AMPD3,ANGPT2,ANXA1,ANXA2,AQP7,ARG1,ARHGEF2,ASNS,ATF3,ATP2B4,ATP9A,B2M,BAIAP2,BAMBI,BCL2L11,BCL3,BHLHE40,C1R,C4BPA,CADM4,Ccl2,CCL24,Ccl7,CCND1,CCND2,CDC42EP4,CDH1,CDH2,CDH3,CDK17,CDKN1A,CEBPD,CFB,CHI3L1,CISH,CIZ1,CKM,COL1A1,COL2A1,COL3A1,COL8A1,COX6B1,CRP,CSF2RB,CTSH,CXADR,CXCL10,CXCL12,CXCL13,CYP1B1,DAPK1,DDX27,ECM1,ECM2,EGR1,EIF4EBP1,EMP3,EPHB2,EPHB6,ERBB3,ESM1,F3,FAM171A1,FGF2,FN1,FOXC1,GAB1,GADD45G,GAP43,GAS7,GBP2,GCA,GLUL,GPNMB,GRHPR,HGF,HIF1A,HLA-A,HSPA2,ICAM1,ID2,IER3,IGFBP6,IL15RA,IL17A,IL33,IL7,IRF1,IRS1,ITGAL,ITPKB,JAG1,JAK3,KLF10,KRT19,LBP,LEPR,LITAF,LMO1,LRG1,LSM4,MAGED2,MAP2,MAPK14,MCM7,MMP2,MPZL2,MRC1,MUSK,MX1,MYH10,MYH7,NEB,NEDD4L,NMT2,NUAK1,OLFML2A,OSMR,P2RY10,PCDHGB6,PDAP1,PDPN,PFKFB3,PGK1,PITX2,PLA2G4A,POLR2E,PPARG,PRDM1,PTGES,PTPRZ1,PYGL,RAB31,RARG,RASD2,RNASE4,RUNX1,SBNO2,SELE,SELP,SERPINB8,SERPINE1,SERPING1,SFRP2,SLC16A1,SLC16A3,SLC4A8,SLC7A8,SOCS1,SOCS3,SORD,SPNS2,SPP1,STAT1,STX11,TAL1,TIMP1,TLR2,TM4SF1,TNC,TNFAIP2,TNFRSF11B,TNFRSF19,TNNC1,TOP2A,TPBG,TPO,TUBA1A,TYRO3,UAP1,UBE2L6,UBQLN2,USP46,VCAM1,VIM,WNT5A,ZC3HAV1,ZFP36 | 1490 (18) |
| TGM2 | -1.10e-01 | enzyme | Inhibited | -4.57e+00 | NA | 0.0e+00 | ACTA1,BCL2A1,BCL6,BIRC3,BTG2,C3,C5AR1,CCL24,CCND1,CCRL2,CD101,CD300C,CD36,CD74,CD86,CD93,CDK6,CEACAM1,CSRNP1,CX3CR1,CXCL10,CXCL12,CXCR5,E2F5,FCER1G,FN1,GCA,GM2A,HIF1A,IFIT1,IL10RA,ITGA6,ITGB3,ITGB4,KRT19,LRRC25,MMP2,MYH7,NCF2,NLRC4,OAS3,OASL,PARP14,PARP9,PHLDA1,PLEKHO2,PTGES,RARA,RFLNB,RNF213,RUNX2,SACS,SELP,SEMA6B,SEMA7A,SIRPA,SLC16A1,SLC20A1,SLC25A15,SP110,SPP1,STAT1,TGFB1,THBS1,TNFAIP2,TNFRSF11B,TP63,UBA7 | 965 (13) |
| MRTFA | NA | transcription regulator | Inhibited | -4.59e+00 | NA | 0.0e+00 | ABLIM1,ACTA1,ACTA2,ACTC1,ACTG1,ACTG2,ALCAM,ANKRD1,BCL2L1,CBFB,CD44,CDC42EP3,CMA1,CNN1,COL3A1,COL5A2,COL6A3,Cox8b,CPA3,CXCL12,CXCR4,CYBA,DDAH1,DIAPH3,DNAJB4,EDN1,EFNA5,EGR1,EGR2,EGR3,EYA2,EZR,F2R,FADS2,FHL1,FIBIN,FLI1,FLNA,FLRT2,FSCN2,G0S2,GADD45A,GAS2,HLA-A,ICAM1,ITGA5,ITGA6,MAP2,MGST2,MYH10,MYOCD,OSTN,P2RY1,PDGFRA,PFN1,PTGS2,RHOBTB1,RUNX1,SELE,SELENOP,SELP,SEMA3D,SERPINE1,SGK1,SLC20A1,SLIT3,STAT1,TAGLN,TAL1,TBXAS1,THBS1,TNC,TST,VCAM1,WNT5A,ZFHX4 | 1194 (22) |
| ITPR2 | 1.20e-01 | ion channel | Inhibited | -4.60e+00 | NA | 0.0e+00 | AFAP1L2,BTK,Ccl2,Ccl7,CD180,CD44,CSF1R,CXCL10,CXCL13,FCER1G,FCGR1A,Ifi47,ITGB2,Naip1 (includes others),NCF1,NLRC4,PIK3CG,PTAFR,RPS2,SEMA7A,SYK,THEMIS2,Tlr13,TLR5,TLR7 | 540 (7) |
| BHLHE40 | -1.59e+00 | transcription regulator | Inhibited | -4.62e+00 | NA | 0.0e+00 | ACTA2,AHR,AK4,ALOX5,ANXA1,ATF3,ATP1B1,ATP2A2,AXL,B2M,BCL2L1,BDNF,BTG1,C15orf48,C1orf21,C3AR1,CALCRL,CASP1,CASP3,CASP8,CAV1,Ccl7,CCR1,CCRL2,CD47,CD74,CD86,CD9,CFB,CNP,CP,CSF2RB,CSK,CTSS,CXCR5,CYBB,DMBT1,ECM1,ELF1,ENO2,EPHX1,EPSTI1,EXT1,FCGR2B,FGL2,FRZB,GBE1,GBP2,GCH1,GCNT2,GDA,GLRX,GNAI3,HCLS1,HDAC9,HIF1A,HK1,HOMER1,IER3,IFI16,IFIH1,IL17RA,IL18BP,IL2RA,IL2RB,IL2RG,INHBA,IPCEF1,IRAK2,IRF5,IRF8,ITGA4,ITGA6,KDM3A,KIT,LCP2,LEF1,LOX,LPAR1,LTB4R,LY75,LYN,MAFF,MET,MITF,MMP14,MSR1,MTHFD2,MYOD1,MYOG,NCF4,NLRP3,NUP93,OLR1,PARP9,PCDH7,PDPN,PER1,PFKFB3,PGK1,PHLDA1,PLA2G4A,PRDX5,PTGS2,PTPN6,PTPRC,RASGRP1,RIPK2,RND3,SAP30,SDC4,SIAH2,SLAMF1,SLC16A3,SLC2A1,SOCS1,SOCS3,SORBS2,SREBF1,STAT1,Tcf7,TES,THY1,TIPARP,TP63,TPBG,TPST1 | 1511 (22) |
| EDN1 | -9.50e-01 | cytokine | Inhibited | -4.64e+00 | NA | 0.0e+00 | ACTA1,ACTA2,ADAM19,ADIPOQ,ANXA1,ANXA5,APLN,ATP2A2,BCL2A1,CALCRL,CCND1,CDH1,CDH2,COL5A1,COL7A1,CXCR4,CYBB,EDN1,EDN3,EDNRB,EGR1,ENAH,ERRFI1,EZR,FGF2,FN1,GATA4,HCN4,HIF1A,ICAM1,INHBA,ITGA2,ITGA5,ITGB3,LEPR,MARCKSL1,MITF,MMP2,MSN,MYH7,MYL2,NCF1,NFATC3,OLR1,PRKCB,PRKCD,PRKCE,PTGS2,RETN,SDC1,SELE,SERPINE1,SKP2,SLC2A1,SOCS1,SOCS3,TBX5,THBS1,TIMP1,TNC,TRPC6,VCAM1,VCAN,VEGFC,VIM,VWF | 1499 (19) |
| TLR3 | 1.00e-02 | transmembrane receptor | Inhibited | -4.65e+00 | NA | 0.0e+00 | ABCA1,ATF3,AUTS2,C3,Ccl2,Ccl7,CD86,CFB,CSRP3,CTSK,CX3CL1,CXCL10,DHX58,DUSP1,EDN1,FLT3LG,GADD45B,GBP2,GBP4,GCH1,HGF,HNRNPU,ICAM1,IER3,IFI16,IFI44,IFI44L,Ifi47,IFIH1,IFIT1,IL1RN,IL33,IRF1,IRF3,ISG15,LIPG,LIX1,MX1,NMI,NR4A1,NTS,OASL,Oasl2,PFKFB3,PHLDA1,PIK3R1,PIK3R3,PLK2,PTGES,PTGS2,PTX3,RSAD2,SELE,SERPINB9,SERPINE1,SOCS1,SOCS3,STAT1,TIMP1,TLR4,TLR7,TNC,TNFAIP8L2,TNFRSF1B,TP63,TSPAN33,UBE3A,USP18,VAV2,ZC3HAV1 | 1077 (16) |
| IRF3 | -6.00e-01 | transcription regulator | Inhibited | -4.70e+00 | NA | 1.0e-02 | B2M,BIRC3,Ccl2,CCRL2,CD86,CDH11,CDH2,CLIC4,CX3CL1,CXCL10,DHX58,FCGR1A,FGF1,FN1,GBP5,ICAM1,IFI16,IFI44,IFI44L,Ifi47,IFIH1,IFIT1,IFITM3,IL17A,IL33,IRF1,IRF3,IRF5,ISG15,NRAP,OAS3,OASL,Oasl2,PARP14,PLCG2,Pmaip1,RSAD2,SAP30,SNAI2,STAT1,TDRD7,TLR4,TNFRSF4,TPST1,UBE2L6,USP18,VCAM1,VIM,ZC3HAV1 | 632 (14) |
| IKBKB | 7.70e-01 | kinase | Inhibited | -4.71e+00 | NA | 0.0e+00 | ABCA1,ACTA2,AMPD3,ANKRD1,ATF3,BCL2L1,BIRC3,BRCA2,C3,CALCR,Cald1,CASP8,Ccl2,CCNA2,CCND1,CCNE2,CCR1,CCR3,CD44,CDC25B,CDH1,CDK2,CDKN1A,CEBPD,CLDN1,COL1A1,COL3A1,CP,CSF1,CSF1R,CTSK,CX3CL1,CXCL10,CXCL12,CXCL16,CXCR4,CYBA,CYP1B1,CYP7B1,DCN,DUSP6,ECT2,EDN1,EGLN1,EGR1,ETS1,EZH2,F3,FGF10,FOXO1,FOXO3,FSCN1,FYN,GADD45A,GBP2,GCH1,GLI1,GM2A,GRK5,HGF,HIF1A,HLA-A,ICAM1,IFI16,IGFBP6,IGFBP7,IKBKB,IL17A,IL1RN,IRF1,ISG15,ITGB3,KIF23,KLF5,MAT2A,MMP2,Mt1,MX1,MYH7,MYO1D,NFKBIA,NFKBIB,NID1,NLRP3,OGN,PCDH7,PLA2G4A,PLIN1,PLK1,PTGS2,PTX3,REL,Rtp3,S100A4,SELE,SEMA3C,SFRP1,SGK1,SKP2,SLC16A2,Slfn2,SMAD7,SNAI1,SOCS1,SOCS3,TERF2IP,TGFB1,TMEM176B,TNC,TNFAIP2,TNFRSF11B,TNFRSF1B,TNFRSF4,TNFSF8,TP63,TRIM63,TWIST1,UACA,VCAM1,VCAN | 1232 (13) |
| CCR2 | NA | G-protein coupled receptor | Inhibited | -4.72e+00 | NA | 0.0e+00 | ADIPOQ,ARG1,BGN,Ccl2,CCL24,Ccl6,Ccl7,CCR1,CCR5,CD86,COL12A1,COL14A1,COL1A1,COL6A3,CSF1,CX3CL1,CXCL10,CXCL12,CXCL13,CXCR4,DCN,F13A1,FBLN1,FBN1,FN1,HTR2B,IGF1,IL17A,ITGAL,LUM,MMP2,OGN,PCOLCE,PRELP,SPARC,TGFB1,TGFBI,THBS1,TIMP1,TNC,VCAN | 1674 (19) |
| BRD4 | NA | kinase | Inhibited | -4.73e+00 | bias | 0.0e+00 | ABCC4,ABLIM1,ACSL5,ACSM3,ACTA2,AMPD1,ANKRA2,BCL2L1,BCL3,BDH1,BHLHE40,BTG2,CCNA2,CCND1,CCND2,CCR1,CDKN1A,COL1A1,COL5A1,CXCR4,CXCR5,DCTPP1,DRAM1,FADS1,FBN1,FKBP11,FN1,GADD45A,GLI1,ICAM1,ID2,IER5,IL2RA,IRF1,IRF4,IRF8,ITGA1,ITGA4,ITGA5,KAT5,KDM3A,KIF23,KLF5,LOX,LOXL1,LOXL2,MAL,MAP4K1,MMACHC,MYCN,NAV1,NUP210,PDGFB,PDGFC,PLAT,POLR3G,PRDM1,SELE,SFXN4,SORD,SPP1,TGFA,THBS1,THBS2,TIMP1,TOP2A,TUBB,TYRO3,WNT5A | 1628 (21) |
| NRG1 | -3.10e-01 | growth factor | Inhibited | -4.73e+00 | NA | 0.0e+00 | ABCA1,ANGPT2,ANKRD1,ARHGEF2,AXL,BCL2L1,BDH2,BDNF,BIN1,CASP3,CAV1,CCND1,CCND2,CDH1,CDKN1A,CDKN2C,CHRND,COL1A1,COL6A3,CXCR4,DAB2,DAD1,DDAH1,DUSP1,DUSP6,EDN1,EEF1A1,EGR1,EGR2,EGR3,ELOA,EMP2,ENO3,ERBB3,ERRFI1,ETV5,FGF1,FGF2,FLNA,FN1,FSCN1,FSCN2,FSTL1,GAD1,GATA4,GDA,GPI,GPX3,HIF1A,IER3,IRF3,ITGB2,ITGB3,JUND,L1CAM,MAF,MDFIC,MITF,MSR1,MUSK,MYBPC3,MYH6,MYL2,MYOG,NCOR2,NR4A1,NR4A3,NR5A1,PFKFB1,PGAM2,PHGDH,PHKG1,PMP22,PRKG2,PTGS2,PYGM,RUNX1,S100B,SART3,SELE,SERPINE1,SGK1,SH2D4A,SLC1A1,SLC2A1,SNAI1,STMN1,THBS1,TNFRSF25,TNNT2,Tnnt3,TOB2,TOP2A,UCN,USF2,UTRN,VEGFC,VIM,ZFP36,ZFP36L2 | 1455 (17) |
| puromycin aminonucleoside | NA | chemical reagent | Inhibited | -4.77e+00 | NA | 0.0e+00 | A2M,A3GALT2,ACTG1,ADAMTS1,ANXA1,ANXA2,ASNS,BCAR1,Bex2/LOC100912195,CD36,CD44,CP,CYBA,CYBB,EMP3,EXOC4,FBLIM1,GCGR,GPNMB,IER3,ITGB4,LAMC2,MRC1,NCF1,NOX4,PLA1A,S100A10,S100A11,SPP1,TES,TIMP1,TMSB10/TMSB4X,Tpm1,TSPAN8,TUBB,UCP3,VIM | 974 (9) |
| IL6 | NA | cytokine | Inhibited | -4.78e+00 | NA | 0.0e+00 | A2M,ABCA1,ABCC3,ABCC5,ACER2,ACKR2,ACTA2,ACVR1,ACVRL1,ADAMTS1,ADAMTS5,ADGRE1,ADGRE5,AGL,AHR,ALDH1A1,ANPEP,ANXA1,AQP4,ARG1,ATF3,ATP2A1,ATP2A2,AXIN2,BAMBI,BATF,BCL2L1,BCL2L11,BCL3,BCL6,BDNF,BGN,BTG2,BUB1,BUB1B,C3,C5AR1,CALCR,CASP1,CASP3,Ccl2,CCL24,CCNA2,CCND1,CCR1,CCR3,CCR5,CD36,CD44,CD48,CD53,CD74,CD83,CD86,CDH1,CDK2,CDKN1A,CEACAM1,CEBPD,CFH,CIB2,CIITA,CISH,COL1A1,COL2A1,COL3A1,COX4I1,CP,CRP,CRYAB,CSF1,CSF1R,CSF2RB,CSF3R,CTSC,CTSK,CX3CR1,CXCL10,CXCL13,CXCR4,CYBB,CYP1B1,CYTIP,DCN,DIO1,DUSP1,DUSP6,DVL1,E2F2,EGR1,EGR2,ENO2,EPHA4,ERRFI1,EZH2,F3,FCGR1A,FCGRT,FGF2,FLI1,FN1,FOXP3,FSCN1,GADD45A,GADD45B,GADD45G,GAP43,GBP2,GCH1,GFAP,GLI1,GLRX,GREM1,Gsta4,GZMB,HGF,HIF1A,HLA-A,HLA-DQA1,HOMER3,ICAM1,ID2,IFI16,IFIT1,IFITM3,IGF1,IGFBP4,IGFBP5,IGFBP6,IGFN1,IKBKE,IL17A,IL1R1,IL1RL1,IL1RN,IL2RG,IL7,IRF1,IRF4,IRF8,IRS1,ITGA1,ITGB3,JUND,KDR,KIF11,KIT,LBP,LCAT,LGALS1,LPL,LRG1,LY86,MACROD1,MAF,MAP2,MET,MKI67,MMP14,MMP2,MRAS,MSR1,MSS51,Mt1,Mt1m/Mt2A,MYCN,MYOD1,NCF2,NFE2L2,NFKBIA,NKD1,NPHP1,OXTR,PDGFB,PENK,PLA2G2A,PLA2G2D,PLA2G4E,PLAT,PLEK,PLK2,PLK4,PPARG,PRDM1,PROM1,PTGES,PTGFR,PTGS2,PTP4A3,PTPRC,RAB27A,RET,RUNX2,S1PR2,SBNO2,SELP,SEMA4A,SEMA6D,SERPINE1,SFTPB,SGK1,SLC41A2,Slco1a4,SMAD7,SMO,SMOX,SNAI1,SNX10,SOCS1,SOCS3,SOX6,SP110,SPC25,SPP1,SRA1,Srsf5,STAT1,STAT6,SV2B,SYP,TAL1,TBC1D9,TBXAS1,TGFA,TGFB1,THBS1,TIMP1,TLR10,TLR2,TLR4,TLR5,TLR7,TLR8,TNC,TNFRSF11B,TNFRSF1B,TNFRSF25,TOP2A,TWIST1,VCAM1,VIM,VTCN1,WEE1,WNT4,WNT5A,XPNPEP2 | 1423 (16) |
| CHUK | -3.50e-01 | kinase | Inhibited | -4.81e+00 | NA | 0.0e+00 | ACKR3,AMPD3,ATF3,BCL2L1,C3,Ccl2,CCL21,CCND1,CCR1,CDKN1A,CEBPD,CLDN1,COL18A1,CP,CSF1,CX3CL1,CXCL10,CXCL12,CXCL13,CYBA,CYP7B1,DCN,DUSP6,EGF,ENAH,F3,FOXC2,GADD45B,GBP2,GBP4,GCH1,GM2A,HEY2,HLA-A,HSP90AA1,ICAM1,IFI16,IGFBP6,IL17A,IL1RN,ISG15,ITGB3,KCNH2,KLF10,KLF5,MAT2A,MFAP5,MMP2,Mt1,MYH2,NFKBIA,NID1,OGN,PCDH7,PLA2G4A,PLK1,PPARGC1B,PTGS2,PTX3,Rtp3,SELE,SEMA3C,SFRP1,SGK1,SLC16A2,Slfn2,SNX10,SOCS3,SPP1,TERF2IP,TGFA,TMEM176B,TNFAIP2,TNFRSF11B,TNFRSF1B,TP63,TWIST1,VCAM1,VEGFC | 1217 (12) |
| thioacetamide | NA | chemical toxicant | Inhibited | -4.82e+00 | NA | 0.0e+00 | AACS,ABCC4,ACP5,ACTA2,ADAMTS1,ADD3,AKAP12,ANXA1,ANXA2,ASNS,BARD1,Bex2/LOC100912195,BGN,BHLHE40,BIRC3,BRCA2,Ccl2,CD200,CD44,CHRND,CLIP2,COL1A1,COL3A1,CP,CPA3,CPQ,CSNK1D,CSRP2,CXCL16,CYGB,DAB1,DBN1,DKK3,EDNRB,EHD3,ELN,EMP1,EMP3,EPHX1,F2R,FANCB,FBLN5,FBN1,FSTL1,FXYD6,GATM,GCGR,GFAP,GNG11,GPD1,GPNMB,GPX3,HGF,HIF1A,HK1,IER3,IGF1,ITGB4,KDR,LAMC2,LGALS1,LOX,LRAT,LTBP1,MBD4,MET,MMP14,MMP2,MS4A2,NFE2L2,PCOLCE,PDGFB,PDGFD,PDGFRA,PKM,PLA1A,PLPP3,PMP22,PRELP,PROM1,PTGFRN,PTGS2,RGCC,S100A10,S100A11,Scd2,SCN1B,SMAD7,SPARC,SPP1,TAGLN,TES,TGFB1,TIMP1,TMEM45A,TMSB10/TMSB4X,Tpm1,TSPAN8,TYRO3,VSNL1,WNT5A | 1655 (20) |
| IFNA2 | NA | cytokine | Inhibited | -4.82e+00 | NA | 0.0e+00 | ADAM17,ADGRE1,ALOX5,ANXA1,B2M,C1R,CAV1,CBFB,CCDC92,CD28,CD86,CDKN1A,CEACAM1,CIITA,CISH,CNP,CXCL10,CXCL13,DAD1,DPP4,EPB41L3,FGF2,GBP2,GBP4,GNAS,HERC6,HIF1A,HLA-A,IFI16,IFI44,IFI44L,IFIH1,IFIT1,IFITM3,IL10RB,IL2RA,IL2RB,IRF1,IRF5,ISG15,LAPTM4B,LPAR6,LYN,MAL,MET,MX1,MYH2,MYRF,OAS3,OASL,PARP9,PLAT,PTAFR,RBL1,REC8,RSAD2,SAMSN1,SDC1,SERPINB9,SLC15A3,SLC18A2,SOCS1,SOCS3,SP110,STAT1,TDRD7,THEMIS2,UBA7,UBE2L6,USP18,VCAM1,VEGFC,ZBTB11,ZC3HAV1 | 1157 (15) |
| SP1 | -5.30e-01 | transcription regulator | Inhibited | -4.83e+00 | NA | 0.0e+00 | ABCA1,ABCC8,ACSL1,ACTA2,ACVRL1,ADAMTS1,ADCY4,ADD3,AHRR,AKAP12,Akr1b7,ALMS1,ALOX12,ALOX5,ANK1,ASNS,ATF3,ATP2A2,BACE2,BDNF,BMP4,CASP3,CAV1,Ccl2,CCNA2,CCND1,CCND2,CD28,CDC25B,CDH1,CDH2,CDK2,CDK6,CDKN1A,CDKN2C,CEACAM1,CEBPD,CHI3L1,CIITA,CITED2,COL1A1,COL2A1,COL7A1,COL8A1,CPLX1,CREM,CRYAB,CXCL10,CXCL12,CXCR4,CYBRD1,CYP1B1,CYP7B1,DIAPH3,DLC1,DNM1,EGR1,ENG,EZR,F2R,F3,FBXL2,FGF10,FGF2,FGFR1,FLNA,FN1,FOLR2,FOXP3,FYN,GLTP,GNAS,GRIA2,HAS2,HDAC4,HDC,HGF,HIF1A,HINT1,HPSE,ICAM1,ID4,IFITM3,IGF1,IGFBP4,IL2RB,IRAK3,IRF1,IRF3,IRF4,ITGA2,ITGAD,ITGB3,JAM2,KCNQ2,KDR,KIT,KLF4,KLF6,KRT19,LCAT,LPL,LTB4R,MAOB,MAT2A,MEOX2,MET,MIER1,MMP14,MMP2,MRC1,Mt1,MYBL1,MYCN,MYH7,NAB2,NCF2,NFKBIA,NOS1,NOX4,NPR1,NPTXR,NR5A2,PCDH17,PDGFB,PDGFC,PDGFRA,PENK,PGK1,PKM,PLA2G4A,PNMT,PPARD,PREX1,PRKAR2B,PRKCB,PRKCD,PRKCE,PROM1,PSIP1,PTGS2,PTN,RANBP1,RARA,RASGRP2,RBL1,RECK,RUNX2,SCTR,SERPINE1,SGK1,SIGIRR,SLC2A1,SLC39A8,SLC7A1,SLC9A3,SMAD7,SNRPN,SOAT1,SOCS1,SPARC,SPN,SPP1,SPTB,SREBF1,STAR,STAT1,TAGLN,TFPI2,TGFB1,THBD,TIMP1,TLR2,TNC,TNFRSF4,TNNC1,TRIB1,TYMS,UBC,UGCG,UGDH,VIM,VWF,WNT9A,ZEB2 | 1648 (21) |
| medroxyprogesterone acetate | NA | chemical drug | Inhibited | -4.85e+00 | NA | 0.0e+00 | ACP5,ACTG1,ACTN4,ADAMTS1,ADCY4,ADRB2,ALDH18A1,ALG2,ALG3,ANGPT2,ARNT2,ARSB,ARSG,B4GALT1,BCAR1,BCL2L1,BCL2L11,BDNF,BIRC3,BMP4,BRCA2,BTG2,BUB1,BUB1B,C15orf48,CAMK2A,CASP3,CAV1,CAV2,Ccl2,CCNA2,CCND1,CCND2,CCNE2,CCR5,CD44,CDC25B,CDK2,CDK6,CDKN1A,CENPF,CLDN1,COL11A1,COL3A1,COL4A6,COL5A1,COL5A2,CSF2RB,CSF3R,CTSK,CXCL10,CXCR4,CXXC4,DAPK3,DCN,DEPDC1,DIAPH3,EDN1,ENAH,ENC1,EOGT,ERBB3,ESPL1,ETS1,EZR,F2R,F3,FAM107A,FGF1,FGF2,FGF9,FGFR1,FMOD,FN1,FOXO1,FYN,FZD2,FZD5,GCH1,GLI1,GLUL,GM2A,GPX3,HGF,HIF1A,HPSE,HTRA3,HYAL3,ICAM1,ID2,ID4,IGF1,IGFBP7,IL1RL1,IL2RA,INHBA,IQGAP2,IQGAP3,ITGA1,ITGA11,ITGA2,ITGA3,ITGA4,ITGA6,ITGA8,ITGA9,ITGB2,ITGB3,KIF11,KIF18A,KIT,KLF5,LAMA2,LAMP2,LEF1,LEPR,LTBP1,MAOB,MCM7,MPZL2,MYH10,MYH2,MYL12B,NCAPG,NFKBIA,NKD1,NOTCH4,NPR1,OGT,PDE1A,PDE3B,PDGFB,PDGFC,PDGFD,PDGFRA,PIK3R1,PIP4K2A,PLCB1,PLK1,PPARG,PRC1,PRICKLE2,PRKX,PTCH1,PTGER3,RAC2,RALGDS,RANBP1,RASGRF1,RASSF5,RBL1,RUNX1,S100A11,SERPINE1,SFRP1,SFRP4,SGK1,SHC2,SLC2A1,SMAD7,SNCA,SOCS1,SPC25,SPRED1,SPRED2,SPRY4,ST6GAL1,STAT1,STAT5B,STT3A,TFPI2,TGFB1,THBS1,THBS2,TMSB10/TMSB4X,TNC,TWIST1,VCAN,VEGFC,WEE1,WNT11,WNT16,WNT2,WNT2B,WNT4,WNT5A,ZBTB16 | 1923 (19) |
| SPI1 | -4.20e-01 | transcription regulator | Inhibited | -4.86e+00 | NA | 0.0e+00 | ACTA2,ADGRE1,BCL11A,BCL6,BTK,C3AR1,CCNA2,CCND1,CCND2,CCNE2,CD180,CD1D,CDK2,CDK6,CDKN1A,CHI3L1,CIITA,COX4I1,COX6B1,CSF1,CSF1R,CSF2RA,CSF2RB,CSF3R,CTSE,CTSK,CTSS,CXCL10,CXCL14,CYBB,DAB2,DUSP6,E2F2,EBF1,EGR2,FCER1G,FCGR2B,FCGRT,FLI1,FOXO1,Foxp1,FUT7,HDAC7,HIC1,ID2,IFI44,IFI44L,IFIT1,IFITM3,IL1RN,IL2RA,IL33,IMP4,IRAK3,IRF4,ISG15,ITGA4,ITGA5,ITGB2,KIT,KLF4,LEF1,LILRB3,LMO2,MME,MMP2,MRC1,MX1,NCF1,NCF2,NCF4,NEIL1,OASL,P2RY10,PIK3CG,PRDM1,PRDX4,PRDX5,PTGS2,PTPN6,PTPRC,RPL18,RSAD2,SNU13,SP110,SPP1,TLR2,TLR4,USP18,VIM | 1331 (15) |
| NONO | -2.00e-02 | transcription regulator | Inhibited | -4.87e+00 | NA | 0.0e+00 | ATP10A,CXCL10,EPHB2,EPSTI1,GBP4,GBP5,GCH1,HCAR2,HERC6,IFI44,IFI44L,IFIH1,IFIT1,IKBKE,ISG15,MX1,OAS3,OASL,PARP14,PARP9,PDE10A,PDE1C,PDE3B,PDE4A,PDE4D,PDE8A,PI4K2B,PNPT1,RNF213,RSAD2,RTP4,SERPING1,SP110,SP140,STAT1,TNFSF18,TNFSF8,UBE2L6,USP18,VAMP5 | 732 (10) |
| MAVS | -1.06e+00 | other | Inhibited | -4.87e+00 | bias | 0.0e+00 | BTK,C6,CASP1,Ccl2,CD83,CFB,COLEC12,CX3CR1,CXCL10,CXCL12,DHX58,HERPUD1,HLA-A,ICAM1,IFIH1,IFIT1,IFITM3,IL15RA,IL18R1,IRAK2,IRF8,ISG15,JAK3,MAT2A,MME,MX1,NOD2,OAS3,OASL,Oasl2,RSAD2,SERPING1,SOCS1,SOCS3,SPP1,STAT1,THBS1,TLR7,TNFRSF11B,UBE2L6,USP18,ZC3HAV1 | 576 (14) |
| TNFSF11 | NA | cytokine | Inhibited | -4.90e+00 | NA | 0.0e+00 | ACP5,ADGRE1,AHR,AHRR,AIF1,BCL2A1,BCL2L1,BMP4,C3AR1,CALCR,CAV1,Ccl2,Ccl7,CCND1,CCR1,CD300LF,CD44,CD83,CDC42EP4,CDK14,CDKN1A,CLEC11A,CSF1R,CSRP1,CTSK,DAB2,DMPK,DOK2,DUSP1,DUSP6,ECT2,EGR2,ETS1,F3,FAM102A,FGR,FHL2,FOXO1,GADD45B,GCH1,GCLC,GLRX,GPR68,HCK,HCLS1,HRH2,HYAL1,ICAM1,IER3,IGF1,IKBKE,IL15RA,IL17RA,IL1RN,IRF4,IRF8,ITGA5,ITGAL,ITGB3,ITPKB,LDB2,LSR,MARCKSL1,MAT2A,NAB2,NFATC2IP,NFATC3,NFIL3,NFKBIA,NFKBIB,PCDH7,PLD1,PLK1,PRDM1,PTGS2,RALGDS,RGL1,SDC1,SDC4,SERPINB9,SERPINE1,SLC20A1,SLC2A1,Slfn2,SOCS1,SOCS3,SOX8,SPP1,STAT1,STMN1,Tcf7,TGFB1,TLR2,TLR4,TNFRSF11B,TNFRSF1B,USP18,VCAM1,ZC3H12C,Zfp101 | 1309 (15) |
| carbon tetrachloride | NA | chemical toxicant | Inhibited | -4.99e+00 | NA | 0.0e+00 | ABCC4,ACTA2,ADGRE1,AK4,ANGPT2,AOX1,ATF3,BCKDHA,BCL2L1,BCL2L11,BIRC3,BMP3,CA3,Calm1 (includes others),CASP3,Ccl2,CCND2,CCR1,CCR5,CD86,CDKN1A,CNR1,COL1A1,COL3A1,CX3CR1,CXCL10,DUSP1,EGF,FAAH,FABP1,FN1,GADD45A,GADD45B,GBP5,GCLC,GFER,Gsta4,HGF,HSP90AA1,ICAM1,IGF1,IGFBP5,IGFBP6,ITGA8,JUND,KDR,MAPK14,MAPK3,MKI67,MMP2,Mt1,NR0B2,NR4A1,PDGFB,PDGFC,PDGFD,PDGFRA,PPARD,PPARG,PROM1,PTAFR,PTGS2,RGN,RIPK3,S100A6,S1PR2,SCTR,SLC2A1,Slco1a4,SMAD7,SORD,SPHK1,SPP1,TGFA,TGFB1,TIMP1,VCAM1,VIM | 1522 (17) |
| MRTFB | NA | transcription regulator | Inhibited | -5.00e+00 | NA | 0.0e+00 | ABLIM1,ACTA1,ACTA2,ACTG1,ACTG2,ADAMTS1,AK5,ALCAM,ANKRD1,ARID5B,BCL2L1,CBFB,CDC42EP3,CDK2,CMA1,CNN1,COL3A1,COL5A2,COL6A3,CPA3,CXCL12,CXCR4,CYBA,DAB2,DDAH1,DIAPH3,DNAJB4,EDN1,EFNA5,EGR1,EGR2,EGR3,EYA2,EZR,F2R,FADS2,FHL1,FIBIN,FLI1,FLNA,FLRT2,G0S2,GADD45A,GAS2,HLA-A,IGFBP5,INHBA,ITGA5,ITGA6,KAZN,LIMCH1,LOXL1,MAP2,MGST2,MYH10,NRXN2,NUAK1,P2RY1,PCDH18,PDGFRA,PDGFRL,PTGS2,PTPRO,RHOBTB1,RUNX1,SAMD5,SDC2,SELENOP,SELP,SEMA3D,SERPINE1,SGK1,SH3D19,SLC20A1,SLIT3,TAGLN,TAL1,TBXAS1,THBS1,TLE1,TST,WNT5A,ZFHX4 | 1131 (16) |
| F2R | -7.80e-01 | G-protein coupled receptor | Inhibited | -5.04e+00 | NA | 0.0e+00 | ANGPT2,BCL2L11,CASP3,Ccl2,CCND1,CD44,CDH1,CDH11,CLDN3,COL13A1,CXCL12,DUSP1,EGR1,EGR3,F2R,F3,FN1,GNA13,ICAM1,IGFBP7,IL17A,ITGA6,KDR,KRT19,LDHB,MMP2,MYOCD,MYOG,NR4A1,PLAT,PTAFR,PTGS2,RGS18,RHOA,S100A4,SELE,SELP,TAGLN,TEK,TFPI2,TGFB1I1,THBS1,TRPC3,VCAM1,VEGFC,VIM,VWF | 1405 (16) |
| phytohemagglutinin | NA | chemical drug | Inhibited | -5.05e+00 | bias | 0.0e+00 | AFF1,AIF1,AQP4,ARSB,BCL3,BCR,BTG1,C6,CACNB2,CACNB3,CALU,CASP3,CCND2,CD44,CD47,CD83,CDH11,CLIC2,COL18A1,CSF1,CUX1,CXCL10,CXCL12,CXCR4,EGR1,ENG,ENPEP,FBN1,FGR,FKBP9,FNTB,FOLR2,GCLC,GNAI1,GNAT1,GPD1,GPD2,GZMB,HINT1,HSP90AA1,ICAM1,IDH3A,IL15RA,IL2RA,IL2RG,ITGA8,ITGB3,JAK3,KIF23,KIT,LAMA2,LBP,LCAT,MAP1A,MAP1B,MET,MIA,NCAM1,PLD1,PLK1,PLP1,PON2,PRKD1,PRKX,PTGER3,PTPN12,PTPN3,PTPRC,PTPRJ,RPS16,RXRA,SELENOP,SLC16A2,SOX10,SPHK1,SPP1,SRP14,SRSF1,STAT1,TIMP1,TRAF5,TYMS,VGLL4 | 1559 (17) |
| SORL1 | NA | transporter | Inhibited | -5.06e+00 | NA | 0.0e+00 | ABCA1,ACVRL1,B2M,BGN,C3,CAV1,CMKLR1,COL11A1,COL13A1,COL18A1,COL1A1,COL2A1,COL3A1,COL5A1,COL5A2,CTHRC1,CXCL12,DCN,DDR2,ECM1,EDN3,EFNA5,ENG,EPHA4,EPHB2,F3,FAP,FBLN1,FN1,FZD2,FZD4,FZD5,HGF,ICAM1,IL16,INHBA,ITGA1,ITGA11,ITGA2,ITGA4,ITGA5,ITGA6,ITGA8,ITGB4,KCND1,LAMA2,LAMA4,LPL,MDK,MET,MIA,MRC2,NID1,NPR1,NRP2,NTS,NXPH3,PDGFC,PDGFRA,PLSCR4,PLTP,PLXND1,RSPO3,RTN4R,SDC4,SEMA3A,SEMA3E,SEMA3F,SFRP1,TACR3,TGFB1,TLR4,TNC,TNFRSF10A,TNFRSF11B,VEGFC,VIPR2,WNT2,WNT5A | 1213 (19) |
| IRF7 | -4.00e-01 | transcription regulator | Inhibited | -5.06e+00 | bias | 0.0e+00 | BCL2L1,Ccl2,CCRL2,CXCL10,DHX58,DNAJA1,FCGR1A,FOXP3,FZD1,GBP4,GBP5,IFI16,IFI44,IFI44L,Ifi47,IFIH1,IFIT1,IFITM3,IL15RA,IL33,IL4I1,IRF1,IRF5,IRF8,ISG15,MICB,MX1,NMI,NRAP,OAS3,OASL,Oasl2,PARP14,RIPK2,RSAD2,RTP4,SAP30,SOCS1,STAT1,TDRD7,TLR4,TLR8,TNFAIP8,TPST1,UBA7,UBE2L6,USP18,ZC3HAV1 | 820 (17) |
| GATA2 | -2.30e-01 | transcription regulator | Inhibited | -5.12e+00 | NA | 0.0e+00 | ADGRE5,AK1,ALOX5,ANGPT2,ARHGEF5,ARNT2,Ccl2,CCL21,Ccl7,CCND1,CCR3,CD226,CD300LD,Cd33,CD34,CD36,CDK6,CDKN1A,CELSR3,CHI3L1,CMA1,CPA3,CSF1R,CST7,CX3CL1,CXCL10,CXCL12,CXCR4,CYBB,DDIT4L,DENND2A,DLK1,DLL1,DMBT1,DUSP15,E2F2,EDN1,EMCN,EPHA3,ETS1,F13A1,F2R,FGD4,FUT7,GBP2,GCSAM,GDA,GFRA1,GP1BB,GPR65,GPX3,GREM1,HBA1/HBA2,HDC,HHEX,ICAM1,IGFBP7,IL16,IL1RL1,IL2RB,ITGA2,ITGA2B,ITGAE,KDR,KHDRBS3,KIT,KLF4,KRT77,LMO2,LTB4R,MAOB,Mcpt4,MCTP1,MCTP2,MDK,MGST1,MMP2,MMRN1,MRGPRX3,MS4A2,NFIL3,NRXN2,PAX3,Pcp4l1,PIK3CG,PLK2,PPARG,PRRG4,RGS18,ROCK1,RUNX1,RXRG,SAMD5,SEL1L3,SELP,SKP2,SLC18A2,SLC9A5,SNCA,SOX18,SPN,SYTL3,TAL1,Tcf7,THBS1,TMPRSS2,TPH1,TRPM2,TUBA8,UACA,UBXN10,VCAM1,VEGFC | 1420 (19) |
| IL5 | NA | cytokine | Inhibited | -5.12e+00 | bias | 0.0e+00 | A2M,ACP5,ALDOA,ANXA2,ASNS,ATP1B1,BCL2L1,BCL3,BCL6,CCND2,CCR1,CCR3,CCR5,CCRL2,CD9,CDKN1A,CEACAM1,CIITA,CISD1,CISH,CITED2,CKAP4,CSF2RB,CSF3R,CTSC,CX3CR1,CXCR4,CYSLTR1,DUSP5,DUSP6,EBP,EGLN1,EGR1,EGR2,EGR3,EIF4EBP1,ELL2,FAM162A,FCGR2B,FGL2,GADD45A,GADD45G,GBP2,GBP4,GBP7,GLIPR2,GPAM,HIF1A,HLX,ICAM1,IER3,IL18BP,IL1RL1,IL2RA,IL2RG,ITGAD,ITGB7,LCP2,LUM,MAT2A,METRNL,MS4A2,MYADM,NABP1,NFIL3,PDLIM1,PGM1,PKIB,PKM,PMP22,PPP5C,PRDM1,PRDX4,PTPRC,RAP1GAP,RASGRP2,S100A4,S100A6,SAP30,Scd2,SEMA4A,SGK1,SKA1,SLC16A3,SLC1A5,SLC2A1,SLC39A8,SNTB1,SOCS1,SPN,TGFB1,THY1,TNFRSF4,TNFRSF8,TNFSF8,TRA2A,VIM,ZNF25 | 1362 (17) |
| adavosertib | NA | chemical drug | Inhibited | -5.15e+00 | bias | 0.0e+00 | BTK,C6,CASP1,CD83,CFB,COLEC12,CTSS,CX3CR1,CXCL10,CXCL12,DHX58,FEZ1,HLA-A,ICAM1,IFIH1,IFIT1,IL10RB,IL15RA,IL18R1,IRAK2,IRF1,IRF5,IRF8,ISG15,JAK3,MME,MX1,NOD2,OAS3,OASL,SERPING1,STAT1,THBS1,TLR5,TNFRSF11B | 1249 (20) |
| IRF1 | -6.20e-01 | transcription regulator | Inhibited | -5.16e+00 | NA | 0.0e+00 | ACTA2,B2M,C1R,CASP1,CASP3,CASP8,CCND1,CD74,CDH2,CDK2,CDKN1A,CEACAM1,CFB,CIITA,CTSS,CXCL10,CXCL16,CYBB,DNASE1L3,ERAP1,F3,FADD,FGL2,FN1,FOXP3,GBP2,GBP4,IFI44,IFI44L,Ifi47,IFIH1,IFIT1,IFITM3,IL17RA,IL18BP,IL33,IL7,IRF1,IRF4,IRF5,ISG15,MX1,NCF2,NSMCE2,OAS3,OASL,PCDH7,PTGS2,RSAD2,SOCS1,SOCS7,SP110,STAT1,TBX3,TGFB1,TRADD,VCAM1 | 1328 (18) |
| Ifnar | NA | group | Inhibited | -5.20e+00 | bias | 0.0e+00 | AXL,B2M,C3,CASP1,Ccl2,Ccl7,CD74,CD86,CXCL10,FCER1G,GBP2,HLA-A,IFI16,IFIH1,IFITM3,IRF1,IRF8,ISG15,ITGA4,NLRP3,NOD2,OASL,PNPT1,RIPK2,RNF213,RSAD2,Sp100,SPP1,STAT1,TLR2,TLR7,UBE2L6,UNC93B1,USP18,VCAM1 | 946 (16) |
| doxorubicin | NA | chemical drug | Inhibited | -5.20e+00 | NA | 0.0e+00 | A2M,A3GALT2,ABCA7,ABCB9,ABCC3,ACAD11,ACTC1,ADAM10,ADAMTS1,ADAMTSL4,ALCAM,ANXA1,ANXA2,AOX1,ASAP3,ASNS,ATF3,ATP2A2,BARD1,BCL2A1,BCL2L1,BCL2L11,Bex2/LOC100912195,BHLHE40,BIRC3,BMP15,BMP3,BMP4,BRCA2,BTG1,BTG2,BTK,BUB1B,CAMK2D,CASP1,CASP3,CASP8,Ccl2,CCL21,CCND1,CD44,CD47,CDC25B,CDH3,CDK14,CDK2,CDKN1A,CGREF1,CHRDL1,CKAP4,CKM,COL3A1,CP,CREM,CXCL10,CYBB,DDIT4,DENND2C,DRAM1,DUSP1,DUSP5,E2F2,EDN1,EEF1A1,EGR1,EMP3,ENG,Esrra,F3,FBLN1,FGF10,FGF16,FOXO3,FOXP3,GAD1,GADD45A,GATA4,GCGR,GCLC,GPNMB,GSR,HIF1A,HSP90AA1,HSPB6,HYAL1,ID2,IER3,IGFBP4,IGFBP6,IGFBP7,INHBA,IRF1,IRF5,Irs3,ISCU,ITGB4,JAG1,KLHL26,KMT5A,LAMC2,LIMA1,LPIN1,MCTP2,MET,MICB,MMP2,MRC1,MYBL1,MYH7,NCAM1,NFE2L2,NFKBIA,NLRC4,NLRP3,NOX4,NR4A1,NTN1,PIK3R3,PLA1A,PLK1,PLTP,Pmaip1,PMEPA1,Podxl,PRC1,PRDX1,PRKAA1,PRKAA2,PTGS2,PTP4A3,Ptprv,RAC2,RBL1,RELN,RETN,RGS6,RGS7,RUNX1,S100A10,S100A11,SCN3B,SDC2,SESN1,SLC19A2,SMAD7,SNAI1,SPHK1,SPP1,SSBP1,STAT1,STMN1,TBC1D8,TERF2IP,TES,TGFA,TGFB1,TIMP1,TLR4,TMC7,TNFRSF10A,TNFSF8,TOP2A,TP53BP2,TP63,Tpm1,TRIM63,TRIM7,TSPAN8,TUBB,UACA,UGCG,VIM,WDR35,WNT4,WNT9A,ZNF281,ZNF385A | 1510 (18) |
| ESRRA | NA | transcription regulator | Inhibited | -5.25e+00 | bias | 0.0e+00 | ABCC5,ACKR3,ACSL1,ACTA1,ACTC1,ACTN2,ADRB2,ANGPT4,ANXA1,APLN,APLNR,ARHGAP24,ATP2A2,C3AR1,CASP8,CASQ2,CD36,CDH2,CHKA,COL1A1,COL8A1,Cox8b,CREB3L1,CRHR2,CSRP2,CSRP3,CTSH,CX3CL1,CX3CR1,CXCL10,CXCL12,CXCR4,CYBB,DEK,EGF,EGR3,EIF2AK3,EMP2,ENPEP,ESM1,Esrra,ETS1,FAM102A,FGF1,FZD5,GAPDH,GJC1,HDAC7,HK1,HSD17B4,HSPB6,IDH3A,IGFBP4,KCNJ11,KRT19,LDHB,LOXL2,LPCAT1,LPL,LRG1,MAOB,MICOS10,MMP14,MMP2,MYBPC3,MYH6,MYH7,MYL2,MYL3,NDUFA1,NR0B2,NRP1,NRP2,PDK4,PKM,PLIN1,PLK2,PLXDC1,PLXND1,PNMT,PPARG,PPARGC1B,PPP2R2B,PRCP,PRKCD,RARA,RUNX2,Scd2,Sp100,SPP1,SPRED1,SSPN,TNFAIP2,TNNC1,TNNT2,TOP2A,UNC5B,VASH2,VAV2,VAV3,WNT11 | 1643 (21) |
| SMARCA4 | 4.80e-01 | transcription regulator | Inhibited | -5.26e+00 | NA | 0.0e+00 | A2M,ABCA1,ABRACL,ACSL5,ACTA1,ACTA2,ACTN4,ADIPOQ,AHR,ALDH1A3,ANO1,ANTXR2,AP1S2,ARHGAP30,ARHGDIB,ASNS,ATP2A1,ATP2B4,AXIN2,BAMBI,BATF,BCL2A1,BIN1,BMP4,CA14,CASP1,CASP3,CCNA2,CCND1,CCND2,CCNE2,CCR1,CCRL2,CD44,CD47,CD74,CDH1,CDH11,CDH2,CDK2,CDK20,CDKN1A,CEACAM1,CIITA,CKM,CLDN1,CLIC2,CLK1,CNP,COL1A1,COL7A1,COTL1,CP,CSF1,CSF2RA,CTSH,CTSS,CXCR4,CXCR5,CYB5R2,CYP4B1,DGKG,DHRS9,DLL1,DUSP6,EBF1,ECM2,EGR1,EMP3,ENO2,ENO3,EPHA4,EPHB2,ESPNL,EVA1A,F3,FADS3,FAM167A,FBLIM1,FGF9,FHL2,FKBP5,FMO2,FN1,GADD45A,GADD45B,GADD45G,GAPDH,GCLC,GLI1,GNAI3,GPM6A,GPR183,GPR68,GULP1,HAPLN3,HCLS1,HDAC4,HK1,HLA-DRA,ICAM1,IER3,IFI16,IFIT1,IFITM3,IGF1,IGFBP4,IGFBP5,IGFBP7,IL15RA,INHBA,IRF1,IRF6,ITGA3,ITGA5,KCNS3,KDR,KHDRBS3,KIT,LAMA3,LAMC2,LEF1,LGALS1,LOX,LOXL2,LRAT,LUM,MAFF,MAOB,MAP1B,Mbp,MC4R,MCTP2,MICB,mir-133,mir-143,MMP2,MPZ,Mt1,MYBPH,MYH3,MYL1,MYOG,MYRF,NECTIN1,NR2F2,NRP1,NRP2,NUAK2,OXCT1,PER3,PGK1,PGM2L1,PHLDB1,PITX2,PKM,PLAT,PLEKHO1,PLPP3,Pmaip1,POLE4,PON3,PPARG,Ppfia4,PTCH1,PTP4A2,PTPN7,PTX3,RAB27A,RAB38,RAC2,RBL1,RETN,RGS2,ROCK1,RUNX2,S100A6,SDC2,SEL1L3,SELENOP,SEMA3B,SEMA7A,SERPINB8,SERPINE1,SERPINH1,SFTPB,SKAP2,SLAMF9,SLC2A1,SMAD6,SNAI1,SNAI2,SPHK1,SPP1,ST3GAL1,STARD10,SYK,TAGLN,TAL1,TEC,TGFB1,THY1,TLR2,TNFAIP8,TNNC2,TNNI2,TNNT2,TRIM36,TSPAN8,TUBB,TWF1,TWIST1,TYMS,UNC13D,VIM,WIPF1,WNT9A,ZNF503 | 1621 (22) |
| IGF1 | -8.80e-01 | growth factor | Inhibited | -5.26e+00 | NA | 0.0e+00 | A2M,ABCA1,Abca8a,ACTA1,ACTA2,ACTN2,ADAMTS2,ADIPOQ,AGAP2,ANGPT2,ANPEP,AQP4,ASGR2,ATP2A1,ATP2B3,AXL,BATF,BCL2A1,BCL2L1,BCL2L11,BDNF,BGN,BHLHE40,BIRC3,BMP4,BTG2,CASP3,CCDC80,Ccl2,Ccl7,CCNA2,CCND1,CCND2,CD44,CD74,CDH1,CDH6,CDK2,CDKN1A,CEBPD,CGNL1,CISH,CITED2,CLEC11A,CNN1,CNP,COBL,COL14A1,COL16A1,COL1A1,COL2A1,COL3A1,COL5A2,COL8A1,CP,CREB1,CRYAB,CSF1,CYBA,CYBB,CYP1B1,DCN,DDIT4,DHH,DUSP1,DUSP6,EDN1,EFS,EGF,EGR1,EGR2,ELN,ERRFI1,F3,FBLN1,FBXO32,FGFR1,FHOD3,Fmnl1,FN1,FOXC2,FOXO1,FOXP3,GADD45A,GADD45G,GAP43,GAPDH,GDF10,GFAP,GPD1,GPD2,HDC,HGF,HIF1A,HOPX,HOXA5,HSPA1A/HSPA1B,ICAM1,ID2,IER3,IFITM3,IGF1,IGFBP4,IGFBP5,IGFBP6,IL16,IL17A,IL1R1,IL2RG,INHA,IRF3,IRS1,IRS2,ITGA3,ITGA5,KCNF1,KCNQ2,KDELR3,KIF1A,KLF6,LASP1,LEPR,LGALS12,LOXL2,LPL,MAPK3,Mbp,MC2R,MDK,mir-133,MKI67,MMP14,MMP2,MPZ,MSTN,MYCN,MYH6,MYH7,MYH8,MYL1,MYOD1,MYOG,NCAM1,NCF2,NFE2L2,NFKBIA,NKX6-1,NNMT,NOX1,NOX4,NR4A1,NR5A1,NTN1,NTRK2,OCLN,OSBPL7,OSMR,PCOLCE,PDGFRA,PEBP1,PENK,PGAM2,PHLDA1,PHLDB2,PIK3C2G,PITX3,PKM,PLA2G2A,PLEK,PLK2,PLOD2,PLP1,PPARG,PPP3CA,PTGS2,PTPRC,Rcan1,RDX,RND1,RUNX2,S100B,Scd2,SEC23A,SELE,SERPINE1,SGK1,SIRT2,SLC12A4,SLC12A7,SLC20A1,SLC25A25,SLC2A1,SNAI2,SOCS3,SORT1,SPP1,SPRED2,SREBF1,SRSF3,STAR,TGFA,TGFB1,TGFBI,THBS1,THY1,TLR4,TMEM208,TNFRSF11B,TNNC1,TNNT2,TRPV1,TSHR,TTF2,TWIST1,UGCG,VCAM1,VEGFC,VIM,VWF,WEE1,WNT4,ZFP36,ZFP36L1,ZFP36L2 | 1899 (18) |
| STAT1 | -9.50e-01 | transcription regulator | Inhibited | -5.27e+00 | NA | 0.0e+00 | A2M,ABCA1,ABCB9,ALDH1A3,ALOX15,ANGPT2,ARG1,AXL,B2M,BCL2A1,BCL2L1,BCL2L11,BCL6,BTG1,C1QTNF7,C1R,C3,CASP1,CASP3,CASP8,CBFA2T3,Ccl2,CCND1,CCND2,CCR1,CCRL2,CD44,CD86,CDK2,CDKN1A,CEACAM1,CEBPD,CFB,CIITA,COL1A1,COL3A1,CREM,CSF3R,CTSS,CX3CL1,CX3CR1,CXCL10,DPP4,DUOX2,EDN1,EGR1,EPSTI1,FCER1G,FCGR1A,FCGR2B,FGF2,FGL2,FN1,FOXO1,FOXP3,GBP2,GBP4,GBP5,HAPLN3,HERC6,HIF1A,HLA-DQA1,ICAM1,IFI16,IFI44,IFI44L,Ifi47,IFIH1,IFIT1,IFITM3,IGF1,IL15RA,IL17A,IL18BP,IL1R1,IL33,IRF1,IRF5,IRF8,ISG15,ITGA2,ITGA5,KLF4,LPL,LYPLA1,MAFA,MX1,MYH7,NKX6-1,NOX1,NOX4,OAS3,OASL,Oasl2,PARP9,PCDH17,Pcsk1,PDGFB,PDGFC,PPARD,PPARG,PPARGC1B,PRKCE,PTGS2,PTN,RNF213,RSAD2,RTP4,RUNX1,RXRA,S100A10,SERPING1,SLFN13,Slfn2,SMAD7,SOAT1,SOCS1,SOCS3,SORT1,SP110,SREBF1,STAT1,TGFA,TGFB1,THBS4,TLR4,TLR8,TNC,TP53BP2,USP18,VCAM1,VWF,ZNF652 | 1386 (16) |
| ELAVL1 | -9.40e-01 | other | Inhibited | -5.29e+00 | NA | 0.0e+00 | 9930111J21Rik1/Gm12185,ABCA1,ACTA2,ANKRD1,APOD,ATF3,AXL,B2M,BATF,BCL2L1,CD83,CD86,CDH1,CDH2,CDK2,CDKN1A,CLDN1,CLDN3,CTSS,DCN,DUSP1,ELAVL1,F830016B08Rik,FLNA,FOXP3,HIF1A,HLA-A,HOMER2,HSPA2,IFI16,IFI44,IFIH1,IFITM3,IL17A,IL1R1,IRF1,IRF4,KIF11,KIF18A,LGALS9B,MAT2A,MYOD1,MYOG,NCAPG,NFKBIA,OCLN,OSBPL2,PCOLCE,PLA2G7,PLCG2,PRC1,PROM1,PTGS2,PTPRC,RFC5,RUNX2,Slfn2,SNAI1,SNAI2,STAT1,SYK,TLR2,TLR4,TOP2A,TP63,USP18,VCAM1,VIM,WEE1,WNT5A,ZFP36 | 1405 (21) |
| RIGI | NA | enzyme | Inhibited | -5.36e+00 | bias | 0.0e+00 | BTK,C6,CASP1,Ccl2,CD83,CFB,COLEC12,CTSS,CX3CR1,CXCL10,CXCL12,DLL1,FEZ1,HLA-A,ICAM1,IFI44,IFIH1,IFIT1,IL15RA,IRAK2,IRF1,IRF3,IRF8,ISG15,JAK3,KLF4,MAT2A,MME,MX1,NFATC4,NMI,NOD2,OAS3,Pmaip1,PTGS2,RSAD2,SERPING1,SOCS1,SOCS3,SPP1,STAT1,THBS1,TLR5,TNFRSF11B,UBA7,USP18,WNT4,ZC3HAV1 | 724 (17) |
| IL1 | NA | group | Inhibited | -5.38e+00 | NA | 0.0e+00 | ADAM17,ADAMTS1,ADAMTS5,ADRB2,AHR,BDNF,BHLHE40,C2,C3,CASP1,Ccl2,CD34,CDKN1A,CEACAM1,CEBPD,CFB,CHI3L1,COL1A1,COL2A1,CP,CRP,CSF1,CSF1R,CSF2RB,CTSC,CXCL10,CYP27A1,DCN,DUSP1,EDN1,EGR1,F2RL3,F3,FN1,FZD5,GFAP,HGF,HIF1A,ICAM1,IGF1,IL17A,IL17RD,IL1R1,IL1RL1,IL1RN,IL2RA,IL2RB,IL33,IL7,INHBA,IRF1,IRF4,ITGB2,KIT,KITLG,KLF6,LOX,LRAT,MMP2,NOX1,NRP2,PANX1,PDGFRA,PLA2G2A,PLA2G4A,PLD1,PPARG,PTGS2,RUNX2,RXRA,SDC4,SELE,SELP,SERPINE1,SFTPB,SLC2A1,SOCS3,SPARC,SPHK1,SREBF1,TGFB1,THBD,THY1,TIMP1,TLR2,TLR4,TLR7,TNC,TNFAIP6,TNFRSF11B,TNFRSF1B,TNFRSF4,UGCG,VCAM1,VCAN,WNT5A | 1557 (16) |
| ZBTB10 | 1.40e-01 | transcription regulator | Inhibited | -5.38e+00 | NA | 0.0e+00 | 9930111J21Rik1/Gm12185,ANXA1,ARID5A,B2M,BCL2L11,CCL24,CD1D,CD244,CD34,CD83,CD86,CX3CL1,CXCL10,CYBB,DHX58,DTX3L,FCER1G,GBP4,GBP5,HK1,HPSE,IFI16,Ifi47,IFIH1,IFIT1,IFITM3,IL10RB,IL1RN,IL2RA,IRF1,IRF4,ISG15,LGALS9B,LPL,MAP3K14,NR4A3,OASL,OPTN,PARP9,PRKCQ,PTGS2,RIPK2,RTP4,SASH3,SEMA7A,SERPINE1,SLFN13,Tlr13,TNFRSF8,UNC93B1,ZBTB20 | 735 (11) |
| IL2 | NA | cytokine | Inhibited | -5.39e+00 | NA | 0.0e+00 | ABCA1,ACSL3,ACVR1B,ADAM19,AHR,ALDOA,ANXA1,ARHGEF2,ARHGEF3,ARNT2,ASNS,AUTS2,BATF,BCAT1,BCL2A1,BCL2L1,BCL6,BHLHE40,BIRC3,BUB1,C3,CACNA1E,CAPN5,CARD6,CASP1,CASP3,Ccl2,CCNA2,CCND1,CCND2,CCNE2,CCR1,CCR3,CCR5,CD200R1,CD244,CD28,CD44,CD47,CD74,CD83,CD86,CD9,CDH1,CDK2,CDK5R1,CDK6,CDKN1A,CDKN2C,CEACAM1,CISH,CMKLR1,CREB1,CSF1,CSF1R,CSF2RA,CSF2RB,CSRNP1,CST7,CTSC,CX3CR1,CXCL10,CXCL12,CXCR4,CXCR5,CYP27A1,CYSLTR1,CYTH4,CYTIP,DAP,DAPK1,DDIT4,DENND2D,DKC1,DNMBP,DPP4,DTX1,DUSP1,DUSP5,DUSP6,ECM1,EDN1,EEF1E1,ELF1,ELMO3,ELOVL5,EMP1,ENTPD1,EPHA4,EPHX1,ETS1,FADS2,FCER1G,FCGR3A/FCGR3B,FCMR,FGF2,FGF9,FGFR1,FGL2,FLT3LG,FOXO1,FOXO3,FOXP3,FYN,GADD45B,GADD45G,GAPDH,GBP2,GCNT1,GFAP,GPR183,GPR34,GPSM1,GZMB,HCK,HHEX,HLA-DQA1,HLA-DRA,HOPX,HSPA1A/HSPA1B,HVCN1,ICAM1,IDH1,IER3,IFI16,IGFBP4,IKZF2,IL10RA,IL17A,IL18BP,IL18R1,IL1R1,IL1RL1,IL1RN,IL2RA,IL2RB,IL2RG,IP6K2,IQCG,IRF1,IRF4,ISG15,ITGA1,ITGA2,ITGA4,ITGA6,ITGAE,ITGB7,JAK3,JUND,KCNA2,KCNK1,KIT,KLF3,KLF6,L1CAM,LCP2,LGALS12,LSR,LTB4R,MAF,MKI67,MME,MMP2,MTHFD2,MX1,NAB2,NAV1,NEB,NET1,NMI,NOP2,NR4A3,NRP1,OSBPL3,PDE3B,PDE4A,PDGFC,PDLIM4,PEA15,PENK,PGK1,PHGDH,PHLDA1,PIK3R3,PLA2G2D,PLAGL1,PLCB1,PLK1,POLR1B,PPARG,PPP2R2B,PPP5C,PRDM1,PRKX,PROS1,PSMB1,PTCH1,PTGIR,PTGS2,PTPN3,PTPN6,PTPN7,PTPRC,PTPRJ,PUS1,RASGEF1B,RGCC,RGS2,RNF128,RNF157,RXRA,S100A4,S100A6,Scd2,SELP,SEMA4A,SERPINB9,SERPINE1,SESN1,SHISA3,SHMT1,SIPA1,SLA,SLAMF1,SLC1A4,SOCS1,SOCS3,SORD,SPP1,SPRED1,SPRED2,STAT5B,STMN1,SWAP70,SYTL2,TFDP2,TGFB1,TIMP1,TLR2,TNFAIP8,TNFRSF10A,TNFRSF11B,TNFRSF1B,TNFRSF4,TNFRSF8,TRAF5,UMPS,VCAM1,VIM,VPS37B,WLS | 1369 (16) |
| decitabine | NA | chemical drug | Inhibited | -5.42e+00 | NA | 0.0e+00 | ABCC3,ABCC4,ABCC8,ADAMTS1,ADRB2,AKAP12,ALOX5,ANKRD1,ANXA2,ARHGDIB,B2M,B3GNT2,BAIAP2,BCAT1,BCL11A,BCL2L11,BDNF,BIN1,BIRC3,BMP4,BMP5,BRCA2,BTG1,BTG3,CA12,CA9,CASP8,CAV1,Ccl2,CCNA2,CCND1,CCND2,CCR3,CD226,CD276,CD44,CD47,CD86,CD9,CDH1,CDH11,CDH2,CDH3,CDH6,CDK5R1,CDK6,CDKN1A,CDO1,CEACAM1,CGREF1,CHI3L1,CNMD,COL1A1,COL3A1,COL6A3,COL7A1,CREB1,CTNNBIP1,CUX1,CX3CR1,CXADR,CXCL10,CXCL12,CXCR4,CYP1B1,CYP4B1,DAPK1,DDR2,DDX6,DEK,DLC1,DMBT1,DNASE1L3,DUSP1,E2F5,E2F8,EDA2R,EEF1A1,EGFL6,EGR3,ELF4,ELOVL4,EPHA3,EPHB4,EPHB6,EYA2,EZR,FBN2,FBXL7,FEZ1,FGF2,FGFR1,FLRT3,FN1,FOXC1,FUBP1,GAD1,GADD45B,GADD45G,GAP43,GFRA1,GLI2,GLRB,GLRX,GPC3,HIC1,HLA-A,HPSE,HSPA1A/HSPA1B,HTR1B,HTRA3,ICAM1,IFI16,IGFBP7,INPP5F,IPCEF1,ISG15,ITGA1,ITGA2,ITGA3,ITGA4,JAG1,KIF5C,KLF4,KLF6,KRT19,L1CAM,LAMA2,LAMA3,LEF1,LEPR,LGALS1,LOX,LTBP1,LUM,MAF,MAOB,MAP1S,MAP2,MET,MIB2,MICALL2,MICB,MKI67,MMP14,MMP2,MOB2,MSI1,MSN,MX1,MYF6,NCAM1,NECTIN1,NEFL,NEIL1,NEK6,NFKBIA,NR4A2,NR5A1,OGT,OLFM1,OSTN,PAWR,PDGFB,PDLIM4,PLCB1,PLK1,PLK2,PON2,PPARG,PREX1,PTCH1,PTGS2,PTPN6,PXDN,RARRES1,RASGRF2,RASSF10,RASSF2,RASSF5,RECK,REL,RELN,RET,RGMA,RIMS2,RNASE4,RRAD,RTP4,S100A10,SALL4,SDC2,SEMA3C,SERPINH1,SFRP1,SFTPB,SGK1,SIAH2,SIRPA,SLC22A17,SLC38A1,SLC4A10,SLC7A1,SMO,SMYD2,SNAI1,SNRPN,SOCS1,SOCS3,SPARC,SPP1,SRSF1,ST14,STAG1,STAR,STAT1,STAT5B,STAT6,STEAP2,STK3,SYK,TFPI2,TGFBI,THBD,THBS1,TLL1,TMSB10/TMSB4X,TNC,TNFRSF10A,TNFRSF25,TOP2A,TP53BP2,TP63,Tpm1,Tpm3,TWIST2,TYRO3,UBXN1,UGDH,UNC13A,USF2,VCAN,VIM,VSIR,WDR77,WNT10B,WNT5A,XPO1,ZFP64,ZFYVE27,ZSWIM6 | 1611 (19) |
| WNT3A | -9.00e-02 | cytokine | Inhibited | -5.43e+00 | NA | 0.0e+00 | ACADL,ACADS,ACTA2,ADAM10,AHR,ALDH1A3,ALPK2,ATP1B1,AXIN2,BCL2L11,BDNF,BGN,BMP4,CACNA1G,Casp12,CCDC80,Ccl2,CCND1,CCND2,CD44,CDH1,CDH2,CDK15,CLEC11A,COL1A1,COL2A1,COLEC12,COX4I1,CST7,CXCL10,CXCL12,DCN,DDIT4,DLK1,DVL1,EDN1,EGR2,ENG,ERBB3,ESRRB,ETV5,FCMR,FHL2,FHOD3,FMOD,FN1,FZD1,FZD2,FZD4,GADD45G,GAP43,GATA4,GGT5,GLI1,GPNMB,HAS2,HAS3,HEY2,IGFBP5,IKZF2,IL7,IRS1,IRS2,JAG1,JAM2,KDR,KIT,KITLG,KLF4,LBH,LEF1,LGALS12,LGR5,LRRC17,MITF,MMP14,MRGPRF,MYF5,MYH2,MYH6,MYH7,NCAM1,NDUFC2,NDUFV1,NEK6,NKD1,NR5A2,OGN,PAX3,PDGFRA,PEX5,PITX2,PLD1,PLIN1,PMEPA1,PMP2,PMP22,PNPLA3,PPARG,PRDM1,PTGS2,PXYLP1,RFLNB,RHOA,RSPO3,RUNX1,RUNX1T1,RUNX2,SDC4,SFRP2,SIM1,SLC1A3,SLC7A1,SPARC,STRA6,SYTL3,TBX3,TBX5,Tcf7,TFCP2L1,TGFB1,THBS1,THY1,TNC,TNFRSF11B,TNFRSF19,TNNT2,TWIST1,UQCR10,UQCR11,VCAM1,VIM,WNT11,WNT5A,WNT9A | 1401 (20) |
| Ige | NA | complex | Inhibited | -5.63e+00 | NA | 0.0e+00 | ADAMTSL4,ALOX5,ANXA1,ARG1,ATP2A2,BAIAP2,BCAT1,BCL2A1,BCL2L1,BCL2L11,BCL3,BCL6,BCR,C3,CARD11,CARHSP1,CAV1,Ccl2,CCL24,Ccl7,CCND2,CCR5,Cd33,CD34,CD53,CD74,CD86,CDC42EP5,CDKN1A,CEACAM1,CHST11,CISH,COBLL1,COL18A1,COQ7,Crip2,CTSK,CX3CL1,CXADR,CXCL16,CXCR5,DUSP6,E2F5,EDN1,EGR1,EGR2,ELMO1,ENO2,ERRFI1,ETV5,F2R,FCER1G,FCGR1A,FCGR2B,FGD2,FHL2,FXYD6,FYN,GADD45B,GNA13,HBA1/HBA2,HDC,HIP1R,HIVEP3,HSD17B12,ICAM1,IER3,IKBKE,IL17A,IL2RA,IL33,IRF4,ITGA5,KIAA2012,KLC1,LCP2,MARCKSL1,MDFIC,MGST2,NABP1,NAPA,NCF4,NFKBIA,NFKBIB,NOX1,NRP1,PDGFB,PEA15,PEBP1,PENK,PFN1,PIP4K2B,PLK3,PPAN,PPARG,PPP1R3B,PRDX1,PTGS2,PTPN6,PTPRF,PTX3,RAB7A,RAB7B,RALGDS,RASA2,RASGRP1,RIPK2,RSAD2,RUNX1,SCIMP,SEMA7A,SLC37A2,SLCO4A1,SOCS1,SOCS3,SPHK1,SPP1,SPRED1,TGFB1,TLR2,TLR7,TMEM71,TNC,TNFRSF10A,TNFRSF11B,TNFRSF1B,Tpm1,TRAF5,TUBB6,UGCG,VAV2,VCAM1,VEGFC,VIM,WNT10B | 1221 (13) |
| NFkB (complex) | NA | complex | Inhibited | -5.64e+00 | NA | 0.0e+00 | A2M,ABCG1,ACKR3,ADAMTS9,ADGRE1,ADRA2A,AHR,ALDH1A3,ANKRD1,ATF3,ATP2A2,ATP6AP2,B3GNT5,B4GALT1,BAMBI,BATF,BCL11A,BCL2A1,BCL2L1,BCL3,BDNF,BIRC3,C1R,C3,CALB1,CAMK2D,CASP1,CASP8,Ccl2,Ccl7,CCND1,CCND2,CD36,CD44,CD7,CD74,CD83,CD86,CDC25B,CDH1,CDKN1A,CEBPD,CFB,CGREF1,CIITA,CLIP2,COL18A1,COL2A1,CREM,CRP,CSF1,CST7,CX3CL1,CXCL10,CXCL12,CXCR4,CYBB,DAD1,DBP,DIO1,DMBT1,DOK5,DUSP5,E2F7,EDN1,EDNRB,EGR1,ELL2,ERAP1,ETS1,F2RL1,F3,FCGR1A,FGF1,FGF2,FN1,FOXP3,FUCA1,G0S2,GAD1,GADD45A,GADD45B,GAP43,GBP2,GCH1,GCLC,GFAP,GFPT2,GLI2,GNAS,GPR34,GRK5,HAS2,HDAC9,HIF1A,HIF3A,HLA-A,ICAM1,IER3,IKBKE,IL10RA,IL15RA,IL17A,IL1RN,IL2RA,IRF1,IRF3,IRF4,ISG15,ITGAL,ITPKB,JAG1,KDR,KIT,KLF3,KRT19,LAMP2,Ldha/RGD1562690,LITAF,MEOX1,MFHAS1,MMP2,MSTN,MTSS1,MYBL1,NCAM1,NCF2,NCOA7,NFKBIA,NOS1,NUAK2,NUMBL,NUP62,OLR1,Pcsk1,PEA15,PIM3,PLA2G2A,PLD1,PLK1,PLK2,PLK3,POU2F2,PPARG,PRDM1,PRKCD,PTAFR,PTGES,PTGS2,PTX3,REL,RSAD2,RUNX1,SDC4,SELE,SERPINE1,SFRP2,SLC12A7,SLC16A3,SLC2A1,SLC2A5,SLC37A4,SLC3A1,SLC7A1,SMAD7,SNAI1,SNAI2,SOAT1,SOCS1,SOCS3,SPP1,STX4,TERF2IP,TFPI2,TGFB1,TIMP1,TLR2,TLR4,TMOD2,TNFAIP2,TNFAIP6,TNFAIP8,TNFRSF11B,TNFRSF4,TPO,TRPC3,TRPC6,TWIST1,VCAM1,VEGFC,VIM,VSNL1,WNT10B,WNT5A,ZFP36 | 1588 (16) |
| SOX4 | NA | transcription regulator | Inhibited | -5.65e+00 | NA | 0.0e+00 | ADAMTS5,ADGRE5,AIF1L,B3GNT5,CASP1,CD1D,CD53,CD74,CDH2,CHAC1,CLIC6,CSRP3,CXCL12,DBNDD2,DDAH2,EFNA5,EIF4E3,EMB,EMP1,ENPEP,ENTPD1,EVI2A,EZH2,FCER1G,FHL1,FN1,Fnbp1l,GPR171,GPR183,GRIA2,IGF1,IGFBP4,LUZP1,MAGI1,MAP7,MARCKSL1,MGST2,Mt1,MYF5,MYOD1,NAV1,NCAM1,NRP1,NRXN2,NUAK1,PARD6G,PLXND1,PPIC,PXYLP1,PYGL,RARRES1,RNASE4,RNF144A,SEL1L3,SEMA3A,SEMA3B,SEMA3C,SEMA3E,SEMA3F,SNX10,SORT1,ST6GAL1,TES,THSD1,TMEM176B,TMEM255A,TNFRSF19,TPH1,TUBA1A,VIM,VOPP1 | NA |
| PRL | NA | cytokine | Inhibited | -5.67e+00 | NA | 0.0e+00 | A2M,AEN,ANXA2,ANXA5,ATP2A2,B2M,BCL2L1,BCL6,BTG1,CAV1,Ccl2,CCND1,CDH1,CDKN1A,CEBPD,CISH,CLDN3,CNN3,COL1A1,COL3A1,COL5A1,COX4I1,CTSH,CTSS,CXCL10,DCN,DHX58,DTX3L,DVL1,ECM1,EGF,EGR1,EPSTI1,ERBB3,FN1,FZD2,GPNMB,GPSM1,HERC6,HERPUD1,ICAM1,ID2,IER3,IFI44,IFI44L,IFIH1,IFIT1,IGFALS,IGFBP5,IL2RA,IRF1,ISG15,ITGA1,KRT19,MGST1,MLKL,MME,MMP14,MSN,NAB2,NEDD9,OAS3,OCLN,PAQR8,PARM1,PARP14,PC,PCOLCE,PDGFRA,PDIA4,PDIA5,PDK2,PDK4,PDLIM4,PDPN,PENK,PGRMC1,PIM3,PLAT,PNPT1,PPM1K,PROX1,PTGFR,RABAC1,RARA,REC8,RNASE4,RSAD2,SDC1,SFRP2,SOCS1,SOCS3,SP110,SPARC,SPP1,STAR,STAT1,TDRD7,TGFB1,TIMP1,TP63,TPH1,USP18,VIM | 1845 (20) |
| IL1B | -4.00e-01 | cytokine | Inhibited | -5.70e+00 | NA | 0.0e+00 | A2M,ABCC3,ACKR2,ACTA2,ADAMTS1,ADAMTS5,ADRB2,AIF1,AKIP1,ALDH1A1,ALOX12,ALOX15,AMPD3,ANTXR1,ANXA1,AQP4,ARG1,ASAH2,ATF3,ATP1A1,ATP2A2,B2M,BAMBI,BARD1,BCL2A1,BCL2L1,BCL3,BCL6,BGN,BIRC3,BMP4,BTG2,BTRC,C19orf25,C1R,C2,C3,CA12,CALB1,CASP3,CAV2,Ccl2,CCL24,Ccl7,CCNA2,CCND1,CCR1,CCR5,CCRL2,CD244,CD44,CD74,CD83,CD86,CDH1,CDH2,CDKN1A,CEBPD,CERS6,CFB,CHI3L1,CIITA,CISH,CLDN1,CLIP2,COL1A1,COL2A1,CP,CREM,CRP,CRYAB,CSF1,CSF2RB,CSRNP1,CTSS,CX3CL1,CX3CR1,CXCL10,CXCL12,CXCL13,CXCL16,CXCR4,CYBA,CYBB,CYP1B1,CYP7B1,CYSLTR1,CYTIP,DAB2,DACH1,DBP,DCN,DDIT4,DHRS1,DIO1,DKC1,DLL1,DPP4,DUSP1,DUSP5,E2F2,E2F7,EDN1,EDNRB,EGLN1,EGLN2,EGR1,EIF2AK3,EIF4EBP1,ELAVL1,ELN,ENG,EPSTI1,ERRFI1,ETV1,F13A1,F2RL1,F3,FABP1,FCGR2B,FGF2,FKBP5,FN1,FOXO1,FUT7,FZD1,G0S2,G6PD,GAD1,GADD45A,GADD45B,GBP2,GBP4,GBP5,GCH1,GCLC,GFRA1,GLI1,GLI2,GM2A,GNAS,GTF2F1,GZMB,HAS2,HGF,HIF1A,HLA-A,HLA-DOB,HLA-DRA,Hmgn2 (includes others),HOMER1,HSPA1A/HSPA1B,ICAM1,ID2,IDH1,IER3,IFI16,Ifi47,IFIT1,IFITM3,IGF1,IGFALS,IGFBP4,IGFBP5,IGFBP6,IKBKE,IKZF2,IL10RA,IL15RA,IL16,IL17A,IL18R1,IL1R1,IL1RL1,IL1RN,IL2RA,IL33,IL4I1,IL7,INHBA,IRAK2,IRAK3,IRF1,IRF4,IRF5,IRF8,IRS1,IRS2,ISG15,ITGA1,ITGA3,ITGA4,ITGA5,ITGA6,ITGA8,ITGB3,ITPKB,JUND,KCNC4,KCNH2,KDR,KLF10,KLF4,KRT19,LAMA3,LAMC2,LBP,LCP1,Ldha/RGD1562690,LEF1,LGALS9B,LOX,LOXL4,MAFA,MAPK14,MARCKSL1,MCTP1,METRNL,MIA,MMP14,MMP2,Mt1,MX1,MYOD1,MYOG,NFAT5,NFE2L2,NFIL3,NFKBIA,NFKBIB,NKX6-1,NMI,NOS1,NOX1,NR0B2,NR2F2,NR4A1,NR4A2,NR4A3,NRP1,NUP210,NXN,OCLN,OLR1,OSMR,OXTR,PCDH7,Pcsk1,PDGFB,PDGFC,PDGFD,PDGFRA,PDPN,PENK,PHLDA1,PIM3,PLA2G2A,PLA2G4A,PLA2G4E,PLA2G5,PLAT,PLD1,PLK3,POLR1B,POLR3G,PPARG,PPARGC1B,PRDM1,PRKCD,PTGES,PTGFR,PTGIS,PTGS2,PTX3,RAC2,RARA,RASA2,REL,RGCC,RGS4,RIMBP2,RIPK2,RSAD2,RUNX2,RXRA,S100A10,S100A6,S100B,S1PR2,SCNN1G,SCUBE1,SCX,SDC1,SDC4,SELE,SELENOP,SEMA3A,SERPINB9,SERPINE1,SERPINF2,SERPINH1,SESN1,SIGIRR,SLAMF1,SLC1A3,SLC20A1,SLC25A25,SLC2A1,SLC2A9,SLC37A4,SLC3A1,SLC9A3,Slco1a4,Slfn2,SMAD7,SMAD9,SMPD3,SNAI1,SNCA,SOCS1,SOCS3,SPAG1,SPARC,SPP1,SREBF1,STAR,STAT1,STAT6,TACC3,TBXAS1,TFPI2,TGFB1,THBD,THBS1,THY1,TICAM2,TIMP1,TLR2,TLR4,TLR7,TLR8,TMEM176B,TNFAIP2,TNFAIP6,TNFRSF10A,TNFRSF11B,TNFRSF19,TNFRSF1B,TNMD,TP63,TPD52L2,TWIST1,UAP1,UBE2L6,UCP3,UGCG,UGDH,USP18,VCAM1,VCAN,VEGFC,VIM,VSNL1,WNT5A,XYLT1,ZFP36 | 1301 (13) |
| STING1 | NA | other | Inhibited | -5.77e+00 | bias | 0.0e+00 | ARG1,BTK,C15orf48,C6,CASP1,CD83,CD86,COLEC12,CX3CR1,CXCL10,FEZ1,GAS7,GBP4,GBP5,HAP1,HDC,HLA-A,HOPX,ICAM1,IFI16,IFI44,IFI44L,IFIT1,IFITM3,IL15RA,IL18R1,IL33,INHBA,IRF5,IRF8,ISG15,JAK3,MME,MMP2,MX1,NOD2,OAS3,OASL,PLAT,PLEKHA4,PTPRC,RSAD2,SERPING1,THBS1,TNFRSF11B,USP18 | 764 (17) |
| CTNNB1 | 2.30e-01 | transcription regulator | Inhibited | -5.79e+00 | NA | 0.0e+00 | ACADL,ACADS,ACTA2,ACTC1,ACTN4,ADAM17,ADGRG2,ADIPOQ,AHR,ALCAM,ALDH1A1,ALDH1A3,ALG3,ANXA1,APCDD1,APOD,AQP4,ARFGAP3,ASRGL1,AXIN2,BAMBI,BCL2L1,BCL2L11,BCL9,BDNF,BGN,BHLHE40,BMP1,BMP4,BOLA1,C6,CA3,CA9,CACNA1G,Ccl2,Ccl7,CCNA2,CCND1,CCND2,CCNE2,CCRL2,CD34,CD36,CD44,CD47,CDH1,CDH11,CDH2,CDKN1A,CEACAM1,CELSR1,CNMD,CNR1,COL1A1,COL27A1,COL2A1,COL3A1,COL4A6,COX4I1,CTHRC1,CX3CL1,CXCL10,CXCL12,CXCL14,CXXC4,CYP1B1,CYP7B1,DIAPH3,DIO1,DIXDC1,DLK1,DTX1,ECM1,EDIL3,EDN1,EDN3,EGR1,ELAVL1,ELMO1,EMX2,ENC1,ENO2,ENO3,EPHB2,EPHB4,ERBB3,ETV1,EYA2,F13A1,F2R,FCER1G,FEN1,FGD2,FGD4,FGF9,FLI1,FN1,FOXC1,FOXC2,FZD1,FZD2,FZD4,FZD5,GAD1,GADD45B,GADD45G,GAP43,GAPDH,GCH1,GFAP,GFPT2,GJB2,GLI1,GLI2,GLUL,GNG10,GPAM,GPAT3,GREM1,HHEX,HIF1A,HOXA5,HSPE1,ID2,ID4,IFI16,IFIT1,IGFBP5,IL10RA,IL17A,IL1R1,IL2RA,IL7,INHA,INHBB,IRF4,IRF8,IRS1,ITGA1,ITGA4,ITGA6,ITGAL,ITGB2,ITGB7,JAG1,JAM2,KDR,KIF23,KIT,KITLG,KLF5,L1CAM,LAMC2,LBH,LEF1,LGR5,LIMD2,LMO2,LPL,MAP1LC3B,MEOX1,MITF,MME,MMP14,MMP15,MMP2,MPZ,MPZL2,MYBPC1,MYCN,MYF5,MYH3,MYH6,MYOD1,MYOG,NCAM1,NDUFC2,NDUFV1,NFAT5,NKD1,NOTCH2,NOX1,NR4A1,NR5A2,NRCAM,NRP2,NTHL1,NTN1,NUMBL,OGN,PAX3,PDAP1,PDE1C,PFN1,PGK1,PGM1,PIK3R1,PITX2,PKM,PKP3,PLIN1,PLIN3,PLK1,PLS3,PMP22,Podxl,POLR2E,PPARD,PPARG,PPP1R13B,PPP3CA,PRDM1,PROM1,PRSS35,PRX,PTCH1,PTGS2,PTPRJ,QPCT,RASSF4,RASSF5,RETN,RFNG,RGN,RPL14,RPL17,RPL18,RPL22,RPL23,RPL28,RPL35,RPL37A,RPL6,RPL7L1,RPS10,RPS11,RPS15,RPS15A,RPS16,RPS18,RPS2,RPS24,RPS3,RSPO3,RUNX2,S100A4,SCN5A,SCRN1,SDC2,SEMA3C,SEMA5A,SERPINE1,SESN1,SFRP1,SFRP4,SGK1,SHOX2,SIX1,SLC1A5,SLC26A7,SMAD6,SMAD7,SNAI1,SNAI2,SOAT1,SORBS3,SOX7,SPP1,SPRY4,SRSF1,STARD7,STAT1,STAT5B,STRA6,SYK,TBX5,Tcf7,TFCP2L1,TGFA,TGFB1,TIMP1,TNC,TNFRSF11B,TNFRSF19,TNFRSF1B,TNNC1,TOB2,TP63,TSPAN8,TWIST1,TWIST2,UGCG,UQCR10,UQCR11,USP46,VCAM1,VCAN,VIM,WNT11,WNT16,WNT2,WNT4,WNT6,WNT9A,ZEB2 | 1689 (23) |
| beta-estradiol | NA | chemical - endogenous mammalian | Inhibited | -5.80e+00 | NA | 0.0e+00 | A2M,ABCA1,ABCC5,ABCC8,ABHD5,ABLIM1,ACER2,ACKR2,ACKR3,ACP5,ACSL1,ACSM3,ACTA1,ACTA2,ACTC1,ACTG1,ACTN4,ADAMTS1,ADAMTS5,ADAMTSL4,ADCY4,ADGRB2,ADGRG2,ADH1C,ADIPOQ,ADORA2A,ADRB2,AHR,AIF1,AKAP12,ALCAM,ALDH18A1,ALDOA,ALG2,ALG3,ALOX15,ANK1,ANO1,ANO2,ANPEP,ANTXR1,ANXA1,ANXA2,AP1B1,APBA1,APCDD1,APOD,ARG1,ARHGEF15,ARHGEF2,ARHGEF28,ARID5B,ARNT2,ARSB,ARSG,ART3,ASB9,ATF3,ATP1B1,ATP6AP2,ATP6V1F,ATRX,B3GNT7,B4GALT1,BACE2,BAMBI,BATF,BCAR1,BCAS1,BCAT1,BCL2A1,BCL2L1,BCL2L11,BCL6,BDNF,Bex3,BGN,BHLHE40,BIN1,BIRC3,BMP4,BMP5,BOP1,BRCA2,BTG1,BTG2,BUB1,BUB1B,BYSL,C15orf48,C1QTNF6,C3,C8orf44-SGK3/SGK3,CA12,CA14,CACNA1D,CACNA1G,CACNB4,CACNG4,CALB1,CALCR,Calm1 (includes others),CAMK2A,CASP3,CAV1,CAV2,CBFA2T3,CBX6,CCDC80,Ccl2,CCL21,CCNA2,CCND1,CCND2,CCNE2,CCNI,CCR1,CCR3,CCR5,CD276,CD44,CD74,CD86,CD93,CDC25B,CDC42EP4,CDH1,CDH11,CDH2,CDK11A,CDK18,CDK2,CDK5R1,CDK6,CDKL2,CDKN1A,CDR2,CEBPD,CELF2,CENPF,CFB,CGN,CGNL1,CHI3L1,CISH,CITED2,CIZ1,CKM,CKMT1A/CKMT1B,CLCN3,CLDN1,CLDN3,CLIC4,CNN1,CNP,CNR1,COL11A1,COL13A1,COL1A1,COL3A1,COL4A6,COL5A1,COL5A2,COL6A5,COL6A6,COL7A1,COL8A2,COLEC12,COX6A2,Cox8b,CP,CREB1,CREB3L1,CREM,CRHR2,CRP,CSF1R,CSF2RB,CSF3R,CSTB,CTSH,CTSK,CXADR,CXCL10,CXCL12,CXCL13,CXCL16,CXCR4,CXXC4,CXXC5,CYBB,CYP1B1,CYP26B1,CYP4B1,CYTH4,DAB2,DAPK3,DBN1,DBP,DCAF6,DCN,DDAH1,DDIT4,DDR1,DHCR7,DHRS9,DIAPH3,DIO1,DLG3,DLL1,DMBT1,DMTN,DNAJC1,DRAM1,DUOX2,DUSP1,DUSP10,DUSP5,DUSP6,DYNLL1,E2F2,E2F8,ECE2,ECH1,ECHDC2,EDN1,EGF,EGR1,EGR2,EGR3,EIF3G,EIF4EBP1,ELAVL1,ELF1,ELK3,EMP1,ENAH,ENC1,EPB41L3,ERBB3,ERRFI1,ESPL1,Esrra,ETS1,ETV1,ETV5,EZH2,EZR,F2R,F2RL1,F3,F5,FAAH,FADD,FADS1,FADS3,FAM107A,FAM111A,FAM151A,FAM162A,FARP1,FBLN1,FBN1,Fbxl19,FCGR2B,FCGRT,FEN1,FGD3,FGF1,FGF2,FGF9,FGFR1,FHL1,FHL2,FHOD3,FLNA,FLOT1,FLRT3,FMO2,FMOD,FN1,FNDC5,FNIP1,FOXC1,FOXC2,FOXN2,FOXO1,FOXO3,FOXP3,FRK,FSCN1,FSTL1,FUCA1,FYN,FZD2,FZD5,G6PD,GAB1,GADD45A,GADD45B,GADD45G,GALNT7,GATA4,GBP2,GCH1,GCLC,GDF6,GFAP,GFRA1,GINS3,GIPC2,GJB2,GLI1,GLI2,GLRB,GLUL,GM2A,GPAM,GPD2,GPR171,GPR88,GPSM2,GPT2,GPX3,GREM1,GRHL1,GRIK4,GRIN3A,GRK5,GSR,Gsta4,H2AC18/H2AC19,H6PD,HAS2,HBA1/HBA2,HCCS,HCK,HDAC4,HERC6,HERPUD1,HEY2,HGF,HIF1A,HIVEP3,HLA-A,HLA-DQA1,HMCN2,HOMER1,HOXC5,HOXD4,HPSE,HRAS,HRH1,HS3ST5,HSD17B12,HSD17B4,HSPA2,HTR2A,HTR7,HTRA3,HYAL3,ICAM1,ID2,ID4,IER3,Ifgga2l1/RGD1309362,IFITM3,IFRD2,IGF1,IGFBP4,IGFBP5,IGFBP6,IGFBP7,IKBKB,IL10RA,IL17A,IL17RD,IL1R1,IL7,INHA,INHBA,INHBB,INPP4B,INPP5F,INPP5J,IP6K3,IQGAP1,IQGAP2,IQGAP3,IRF1,IRF4,IRF5,IRF6,IRS1,IRS2,IRX5,ISG15,ITGA1,ITGA11,ITGA2,ITGA3,ITGA4,ITGA6,ITGA8,ITGA9,ITGAE,ITGB2,ITGB3,ITGBL1,ITM2C,ITPK1,JAG1,JAM2,JAZF1,JUND,KAZN,KCNF1,KCNK6,KDELR2,KDELR3,KDM4B,KDR,KIF1A,KIF4A,KIT,KITLG,KLF10,KLF4,KLF6,KLF9,KLHL26,KLHL38,KRT19,L1CAM,L3MBTL1,LAMA2,LAMA3,LAMP2,Ldha/RGD1562690,LEF1,LEPR,LGR5,LHFPL2,LIMA1,LITAF,LMCD1,LOC100359583/Ptma,LOX,LOXL4,LPCAT2,LPIN1,LPIN3,LPL,LTBP1,LUM,MAF,MAGI1,MAL,MAL2,MAOB,MAP2K2,MAPK14,MAPK3,Marcks,MATN2,MAX,MB,MBD4,MCM7,MDFIC,MDK,ME3,MEDAG,MET,MGAT3,MGST1,MICAL2,MICU1,MKI67,MME,MMP14,MMP2,MMRN1,MOSPD2,MPZ,MRC1,MRGPRX2,MS4A2,MSMO1,MSN,MVK,MX1,Mxra7,MYBL1,MYCN,MYF5,MYH10,MYH2,MYH3,MYH6,MYH7,MYL12B,MYO10,MYOD1,MYOF,MYOG,NARF,NCAM1,NCF2,NCOR2,NECTIN1,NEDD4L,NEDD9,NET1,NFAT5,NFATC3,NFE2L2,NFKBIA,NFYA,NHP2,NID1,NKD1,NOS1,NOTCH2,NOTCH4,NPR1,NPR2,NPR3,NPTXR,NR0B2,NR1D2,NR2F1,NR4A1,NR4A2,NR4A3,NR5A1,NR5A2,NRP1,NRP2,NTN1,NTS,NXN,NXPH3,Oasl2,OAZ1,OCLN,OGN,OLFML3,OSBPL3,OSBPL7,OVOL2,OXCT1,OXTR,P2RY6,PAM,PAMR1,PARM1,Pcp4l1,PDAP1,PDE1A,PDE3B,PDGFB,PDGFC,PDGFD,PDGFRA,PDIA4,PDK2,PDK4,PENK,PES1,PGK1,PGPEP1,PGRMC1,PHLDA1,PIK3C2B,PIK3R1,PIK3R3,PIP4K2A,PKIB,PKM,PLA2G4A,PLA2G5,PLAGL1,PLAT,PLCB1,PLEKHA4,PLK1,PLK2,PLXDC1,PLXNA4,PMP22,PNRC2,POLA1,PON2,PPARG,PPARGC1B,PPIB,PPM1K,PPP1R36,PPP1R3B,PPP1R3C,PPP2R2B,PPP3CA,PPP5C,PRC1,PRDX4,PRDX5,PREB,PRELP,PRICKLE2,PRKAA2,PRKCB,PRKCD,PRKCZ,PRKX,PROM1,PROS1,PRSS35,PSMB1,PTCH1,PTGER3,PTGES,PTGFR,PTGIS,PTGS2,PTP4A2,PTPN12,PTPN6,PTPRB,PTPRJ,PTX3,PVALB,PXDN,PYGL,RAB2A,RAB31,RAB7A,RAC2,RALGDS,RANBP1,RAP1GAP,RARA,RASGRF1,RASGRP1,RASGRP2,RASSF10,RASSF5,RBL1,Rcan1,RCAN3,RDH10,RDX,REL,RERG,RET,RGS18,RGS2,RGS7,RND1,RND3,RNF128,ROCK1,RP2,RPL14,RPL17,RPL6,RPS11,RPS3,RPS6KB1,RTP4,RUNX1,RUNX2,RXFP1,RXRA,S100A11,S100A13,S100A4,S100A6,SAP30,SCN4A,SDC1,SDC2,SDC4,SDK2,SEC14L2,SELE,SELENBP1,SELENOP,SELP,SEMA3A,SEMA3B,SEMA3C,SEMA3F,SEMA7A,SERPINE1,SERTAD4,SFRP1,SFRP2,SFRP4,SFRP5,SFXN5,SGK1,SGSM2,SHC2,SIAH2,SIGLEC8,SIM1,SKP2,SLA,SLC10A3,SLC12A4,SLC12A7,SLC16A1,SLC19A2,SLC1A3,SLC20A1,SLC20A2,SLC25A15,SLC25A25,SLC2A1,SLC2A13,SLC38A2,SLC38A3,SLC38A9,SLC39A6,SLC41A2,SLC4A4,SLC6A13,SLC6A9,SLC7A8,SLC9A1,Slco1a4,SLCO2A1,SLCO2B1,SMAD6,SMAD7,SMAD9,SMC2,SMOC1,SMPD3,SMTNL2,SNAI1,SNAI2,SNCA,SOBP,SOCS1,SOCS3,SORCS1,SORD,SOSTDC1,SOX18,SPARC,SPDEF,SPEG,SPHK1,SPN,SPRED1,SPRED2,SPRY4,SREBF1,SRSF1,Srsf5,ST6GAL1,ST8SIA4,STAR,STARD7,STAT1,STAT5B,STBD1,STEAP1,STK3,STRA6,STT3A,STX3,SYBU,SYK,SYP,SYT3,TACR3,TBC1D9,TCF15,TEF,TESK1,TFPI2,TGFA,TGFB1,TGIF2,THBD,THBS1,THBS2,THBS4,TIMM13,TIMP1,TJAP1,TLR2,TLR4,TM4SF1,TMEM132B,TMEM164,TMOD2,TMSB10/TMSB4X,TNC,TNFAIP6,TNFAIP8L3,TNFRSF11B,TNFRSF1B,TNFSF8,TNK2,TNNC1,TNNC2,TNNT1,TNNT2,TOP2A,TOP3B,TP63,TPD52L1,Tpm3,TPO,TRAM1,TRHDE,TRIB1,TRPC3,TRPC6,TRPM4,TRPV1,TRPV2,TSHR,TSKU,TTC9,TWIST1,TXNL4A,TYRO3,UGT8,UNC5C,USP19,VAV3,VCAM1,VCAN,VEGFC,VIM,VIPR2,VWF,WEE1,WHRN,WLS,WNT10B,WNT11,WNT16,WNT2,WNT2B,WNT4,WNT5A,XPA,XPO1,ZBTB16,ZBTB20,ZBTB38,ZC3HAV1,ZEB2,ZFHX4,ZFP36,ZFP36L1,ZFP36L2,ZNF212,ZNF219,ZNF503,ZNF638,ZNRF1,ZSWIM6 | 2064 (22) |
| E. coli B4 lipopolysaccharide | NA | chemical toxicant | Inhibited | -5.81e+00 | NA | 0.0e+00 | ADAMTS5,ADCY7,AMPD3,ANXA1,ARHGAP30,B3GNT5,BCL2L1,CA13,CASP3,CASP8,Ccl2,CD83,CD86,CLDN1,CXCL10,CYP27A1,CYTH4,ELF1,EMB,EVI2B,F13A1,F3,F5,FADD,FBLIM1,FCER1G,FCGR1A,FGL2,FIBIN,GADD45G,GBP2,GBP4,GNAI1,GPNMB,HGF,HLA-A,ICAM1,IFI16,IFITM3,IL17A,IL1R1,IL1RN,IL33,IMP4,INPP5D,INVS,IRAK3,KLHL21,KLHL6,LCP1,LCP2,LILRB3,MDFIC,MRC1,NCF1,NFKBIA,NLRP3,NOX1,Oasl2,PARP9,PLA2G4A,PLEK,PROS1,PTGES,PTGS2,PTPN6,PTPRC,PYCARD,RAB7B,RHBDF2,RSAD2,RTP4,SAMSN1,SELE,SERPINH1,SLAMF9,Slfn2,SNCA,SOCS1,SOCS3,ST3GAL1,TLR2,TLR4,TNFRSF1B,TNFRSF4,TNFRSF8,TNFSF8,TRADD,TRAF5,UHRF1,USP18,VCAM1 | 1076 (16) |
| TCF7L2 | -2.40e-01 | transcription regulator | Inhibited | -5.90e+00 | NA | 0.0e+00 | AATK,ACADL,ACSL1,ACSL3,ADO,ALOX5,AMHR2,ANXA1,APCDD1,APOD,ARAP2,ARHGDIB,ARHGEF10,ASPA,ATP8B1,AXIN2,BAMBI,BIN1,BMP4,CARHSP1,CCND1,CCND2,CD44,CDKN1A,CNP,CREB5,CSF3R,CSRP1,CTNNAL1,DBNDD2,DMP1,DOCK10,DUSP15,EDN1,ELOVL1,ENC1,ERBB3,EVI2A,EVI2B,FA2H,FABP1,FBP2,FBXO32,FGF1,FMNL2,FN1,FNTB,GAB1,GLI1,GLTP,GLUL,HSPA2,ID2,ID4,IDH1,IRS1,IRS2,JAG1,KDM4B,KIF19,KLHL2,KLHL4,KMT5A,LAMA3,LAMC2,LBH,LEF1,LRRN1,MAFA,MAG,MAL,MAN1A1,MAP7,MET,MIA,MOG,MOSPD2,MYRF,NCOR2,NINJ2,NR2F2,NUDT4,OPALIN,PCSK1N,PIM3,PIP4K2A,PITX2,PLAT,PLEKHG3,PLP1,PPARD,PPARG,PRRG1,PTGS2,RAB31,RALGDS,RASGEF1B,REEP3,RHOA,RNASE4,ROCK1,SDC2,SECISBP2L,SGK1,SIRT2,SLC44A1,SMAD7,SNAI2,SNX18,SORBS3,SOX10,SPP1,SRSF1,SYTL2,TAF10,TMEM123,TMEM141,TMEM63A,TP63,TPPP,TRIM59,TSPAN2,TWF1,UGT8,VCAN,VIM,ZDHHC9,ZNF536 | 1536 (20) |
| Vegf | NA | group | Inhibited | -5.98e+00 | NA | 0.0e+00 | A2M,ACKR3,ACKR4,ACTA2,ADAM10,ADAMTS1,ADORA2A,AHR,AKAP12,ANGPT2,ANGPT4,ANPEP,APLN,APLNR,AQP4,ASNS,ATF3,AXIN2,BCL2A1,BCL2L11,BUB1,BUB1B,CALB1,CALCRL,CASP1,CASP3,CASP8,Ccl2,CCNE2,CD44,CD93,CDC14A,CDC25B,CDH1,CDK2,CDKN2C,CELSR1,CENPF,CHI3L1,CHST7,CLDN1,CNN1,CPA3,CRYAB,CSGALNACT1,CXCL10,CXCL12,CXCR4,CYYR1,DENND2D,DKC1,DOK5,DUSP5,DUSP6,EBP,EDN1,EGR1,EGR2,EGR3,ELN,EMCN,EMP1,EMP2,ENTPD1,EPHA4,ERBB3,ESM1,ETS1,ETV5,F3,FGF16,FGF2,FKBP5,FLNA,FN1,FOXN2,GAB1,GJB2,GNA13,GPSM2,GRK5,HACD2,HDC,HERPUD1,HIF1A,HOMER1,HOPX,HPSE,HTR7,ICAM1,IGFBP4,IL15RA,IL1R1,INHBA,INHBB,IRF1,IRF4,ITGA10,ITGA2,ITGA6,JAM2,KDR,KIAA1671,KIF11,KITLG,LEF1,LPAR1,LPAR6,LRAT,LY75,LYN,MAGI1,MALL,MAOB,MAPK14,MEOX2,MET,MGST2,MID1,MKI67,MMP14,MMP2,MYCN,NAB2,NOP2,NOTCH4,NPL,NR2F2,NR4A1,NR4A2,NR4A3,NR5A2,NRARP,NRCAM,NRP1,NRROS,OSMR,OXTR,PC,PDK4,PEX5,PHLDA1,PIK3CG,PLK1,PLK4,PLOD2,PLPP3,PLVAP,PMP22,PPAN,PPARD,PRC1,PRDM16,PRKAA1,PRKCB,PTGS2,RECK,RGCC,RGS2,RGS20,SELE,SFRP1,SGK1,SH3TC2,SKP2,SLC12A4,SLC19A2,SLC20A1,SLC27A1,SLC7A1,SLCO2B1,SMC2,SOCS3,ST8SIA4,TBC1D8,TCF23,TGFB1,THBD,TIMP1,TMC7,TNC,TNFRSF11B,TPST1,TRAF5,TRIB1,UGCG,VAV3,VCAM1,VEGFC,VIM,VWF | 1598 (19) |
| SLC15A4 | 4.50e-01 | transporter | Inhibited | -5.98e+00 | bias | 0.0e+00 | ADAMTS1,ALDH18A1,ANXA1,ANXA2,ASNS,BCL2A1,CCNA2,CKAP4,CNP,COL1A1,CXCL10,DOCK10,DOCK2,EDEM1,ENTPD1,EPSTI1,EZH2,F2R,FKBP11,GBP4,GBP5,IFI16,IFIT1,IL1R1,KDELR3,KRT19,LOXL1,MARCKSL1,MMP2,MSR1,MTHFD2,Mxra7,MYOF,OASL,Oasl2,PON3,PPP1R14B,PRC1,PTGS2,PTPN6,RGS10,S100A6,SEC24A,SHTN1,SLA,ST6GAL1,TACC3,TLR7,TNFAIP6,TPBG,TSPAN8,TUBA1A,TUBB,TUBB6,USP18,VCAM1,VIM | 924 (16) |
| cardiotoxin | NA | chemical - other | Inhibited | -6.11e+00 | bias | 0.0e+00 | ACSL5,ADAM10,APLN,ATP6V1A,B2M,BDNF,BGN,C5AR1,CASP1,CASP3,Ccl2,CCL24,Ccl6,Ccl7,CCNA2,CCND1,CCND2,CCNE2,CCR1,CCR5,CD180,COL1A1,CSF1,CSF1R,CSF2RB,CSF3R,CTSH,CX3CL1,CXCL10,CXCL13,CXCR4,DCN,DHH,DLL1,DOK2,DPP4,E2F2,EDNRB,EGF,ERFE,EZR,FEN1,FGF2,FGF9,FGFR1,FNDC5,FSTL1,G6PD,GDF11,GM2A,GNAI3,HGF,HSP90AA1,IGF1,IGFBP7,IL10RA,IL10RB,IL16,IL17A,IL1R1,IL1RN,IL2RG,IL33,IL7,INHBA,ITGA1,ITGA4,ITGA5,ITGA6,ITGB2,ITGB7,Klra2,LRG1,LTB4R,LTBP1,LY86,MCM7,METRNL,MMP15,MMP2,MRC1,MSTN,MYF5,MYF6,MYOD1,MYOG,OSTN,PAX3,PDGFB,PLAGL1,PTN,PTPRC,RANBP1,RBL1,SERPINE1,SERPINF1,SFRP2,SFXN1,SPP1,TGFB1,THBS1,TIMP1,TNFRSF10A,TNFRSF11B,TNFRSF1B,TNFRSF8,TNNC1,TNNT1,TPO,TSHZ3,UCP3,VEGFC,WNT16 | NA |
| 8-bromo-cAMP | NA | chemical reagent | Inhibited | -6.14e+00 | NA | 0.0e+00 | ABCA1,ACP5,ACTG1,ACTN4,ADCY4,ADRB2,ALDH18A1,ALG2,ALG3,ARG1,ARNT2,ARSB,ARSG,B4GALT1,BCAR1,BCL2L1,BIRC3,BMP4,BRCA2,BUB1,BUB1B,CAMK2A,CAV1,CAV2,Ccl2,CCNA2,CCND1,CCND2,CCNE2,CDC25B,CDK2,CDK6,CDKN1A,CLEC11A,COL11A1,COL3A1,COL4A6,COL5A1,COL5A2,CREB1,CREM,CSF2RB,CSF3R,CTSK,CXXC4,CYP1B1,DAPK3,DCN,DIAPH3,DUSP1,EDN1,EGR1,ENAH,ENC1,ENTPD1,EOGT,ERBB3,ESPL1,ETS1,EZR,F2R,FAM89B,FGF1,FGF2,FGF9,FGFR1,FN1,FOXO1,FYN,FZD2,FZD5,GCH1,GFAP,GLI1,GLUL,GM2A,GNAI1,GNAI3,GPX3,HIF1A,HPSE,HYAL3,ID2,ID4,IGF1,IL1RL1,INHA,INHBA,INHBB,IQGAP2,IQGAP3,ITGA1,ITGA11,ITGA2,ITGA3,ITGA4,ITGA6,ITGA8,ITGA9,ITGB3,KDR,KIT,KITLG,LAMA2,LAMP2,LEF1,LEPR,LOX,LTBP1,MAOB,MAT2A,MCM7,MYH10,MYH2,MYH6,MYH7,MYL12B,NFIL3,NFKBIA,NFYA,NKD1,NOS1,NOTCH4,NPR1,NR5A1,NRP1,OGT,PDE1A,PDE3B,PDE4A,PDE4D,PDGFB,PDGFC,PDGFD,PDGFRA,PIK3R1,PIP4K2A,PLAT,PLCB1,PLK1,PPARD,PPARG,PPP1R1A,PRICKLE2,PRKX,PTCH1,PTGER3,PTGFR,PTGS2,RAC2,RALGDS,RASGRF1,RASSF5,RBL1,RUNX1,SERPINE1,SFRP1,SFRP4,SGK1,SHC2,SLC2A1,Slco1a4,SMAD7,SNCA,SOCS1,SPP1,SPRED1,SPRED2,SPRY4,ST6GAL1,STAR,STAT1,STAT5B,STT3A,TFCP2L1,TGFB1,THBS1,THBS2,TIMP1,TMSB10/TMSB4X,TNC,TPO,TSHR,VEGFC,WEE1,WNT11,WNT16,WNT2,WNT2B,WNT4,WNT5A,ZBTB16 | 2027 (24) |
| F2 | -4.30e-01 | peptidase | Inhibited | -6.16e+00 | NA | 0.0e+00 | ACTA2,ADAMTS9,ADIPOQ,ANGPT2,B3GNT5,B4GALT1,BCL3,BIRC3,CASP1,CASP3,Ccl2,CCNA2,CCND1,CCND2,CD36,CD44,CDKN1A,CKAP4,CLIC1,COL1A1,CORO1C,COTL1,CX3CL1,CXCL10,CXCL13,CXCR4,CYBB,DAAM1,DHRS9,DKK3,DOCK10,DOK5,DUSP1,E2F7,EDN1,EDNRB,EGR1,EHD4,ELL2,ENTPD1,ESM1,ETS1,F2R,F2RL1,F2RL3,F3,FABP1,FGF2,FHL1,FN1,GNA13,GREM1,HAS2,HDAC9,HIF1A,HOXD10,HSP90AA1,HYAL3,ICAM1,IER3,IFRD2,IGF1,IGFBP4,IGFBP5,IL15RA,KDR,KLF6,LAMP2,LBH,LMCD1,LOXL2,MAPK3,MEOX1,MFHAS1,MMP2,MTSS1,MYOG,NCF1,NCF2,NCOA7,NFKBIA,NR4A3,NUAK2,NUP62,PDGFB,PDGFRA,PDIA4,PGM2L1,PLA2G4A,PLAT,PRKCE,PROS1,PTGS2,RAC2,RDH5,RHOA,S100B,SDC4,SELE,SELP,SERPINE1,SKP2,SLC12A7,SLC7A1,SYP,TAGLN2,TEK,TFPI2,THBD,THBS1,TNNT2,TRPC3,VCAM1,VWF | 1444 (14) |
| poly rI:rC-RNA | NA | biologic drug | Inhibited | -6.23e+00 | NA | 0.0e+00 | AARSD1,ABCA1,Abi3bp,ACO2,ACSL3,ADAM10,AFAP1,ANXA1,ARG1,ARID5A,ASB13,ATF3,ATP10D,AUTS2,AXL,B2M,BCL3,BIRC3,BUB1,C2,C3,Casp12,Ccl2,CCNA2,CCND2,CCR1,CCR3,CD200,CD36,CD44,CD47,CD74,CD83,CD86,CD9,CDC14A,CDH1,CDH2,CDK14,CDKN1A,CEACAM1,CEBPD,CENPF,CFB,CHD7,CIITA,CMPK1,CNP,COQ9,CRP,CSF1,CX3CL1,CXCL10,CXCR4,CYP1B1,CYP4F2,DDIT4,DHX58,DIO1,DLK1,DLL1,DTX3L,DUSP1,DUSP5,EGR1,EPSTI1,ERFE,EXT1,EZR,FAU,FCGR1A,FCGR2B,FGF2,FLI1,FN1,GADD45B,GATM,GBP2,GBP4,GBP5,GCA,GCH1,GCSAM,GLI1,H2-T24,HERC6,HIF1A,HLA-A,HPSE,ICAM1,IFI16,IFI44,IFI44L,IFIH1,IFIT1,IFITM3,IGF1,IGFBP6,IKBKE,IL10RA,IL15RA,IL17A,IL1RN,IL2RA,IL2RG,IL33,IL4I1,INHBA,IQGAP2,IRAK2,IRF1,IRF3,IRF5,IRF8,ISG15,ITGA5,IWS1,JAG1,KLF4,KLF6,KRT19,LGALS9B,LIPG,LPL,LYN,MAFF,MAX,MKI67,MMP2,MOG,MOV10,MRAS,MRPS9,MSR1,MX1,NAAA,Naip1 (includes others),NCOA7,Ndufs5,NEDD9,NFIL3,NFKBIA,NLRP3,NMI,NOD2,NOP2,NOTCH4,NR4A1,NR4A2,NR4A3,OAS3,OASL,Oasl2,OLR1,OPTN,P2RY6,PARP14,PES1,PFKFB3,PHLDA1,PIK3R3,PIM3,PNPT1,PPM1K,PRKCD,PRKCQ,PSIP1,PTGS2,PTPRJ,PUS1,RAB27A,RASSF4,REL,RGS2,RNPC3,RPL17,RPS2,RRP9,RSAD2,RTP4,SDC4,SELE,SERPINE1,SERPING1,SFRP2,SIRPA,SLAMF1,SLC25A28,SLFN13,Slfn2,SNAI2,SNU13,SOCS1,SOCS3,Sp100,SP110,SSBP3,ST6GAL1,ST8SIA4,STAR,STAT1,SUOX,SYK,TBX3,TDRD7,TFPI2,TGFA,TGFB1,THBD,THBS1,TIAM2,TIFA,TIMP1,TIPARP,TLR2,TLR4,TLR5,TNFAIP2,TNFAIP6,TNFAIP8L2,TNFRSF10A,TNFRSF11B,TOP2A,TPO,TRPV1,TSHR,UBA7,UBE3A,USP18,VAMP5,VCAM1,VEGFC,VIM,WDFY4,WNT5A,XPO1,ZC3H12C,ZC3HAV1,ZFP36 | 1247 (15) |
| CG | NA | complex | Inhibited | -6.27e+00 | NA | 0.0e+00 | ACSL1,ACTA2,ADAMTS1,ADAMTS9,ADH7,Akr1b7,ALDH1A1,ANK2,APCDD1,APLN,APLNR,ARID5B,AXIN2,B2M,BAMBI,BARD1,BCAT1,BCL2L1,BDNF,BEST1,BHLHE40,BMP4,BRCA2,BTG1,BTG2,BTG3,C1R,C2,CBFA2T3,CCDC86,Ccl2,Ccl7,CCNA2,CCND1,CCND2,CCNE2,CD34,CD93,CDH1,CDH2,CDKN1A,CEBPD,CFB,CNN1,CNPY4,COL11A1,CREB1,CREB5,CREM,CRYAB,CSF1,CX3CL1,CXCL10,CXCL12,CXCR4,CYP1B1,CYP7B1,DHCR7,DNAH11,DUOX2,DUSP1,DUSP6,E2F7,E2F8,EBP,EDN3,EGR1,ELK3,EMB,EMCN,EMP1,ENPP3,EPB41L4B,EPHA3,EPHB6,EPSTI1,ESM1,ETV1,F2RL1,F3,FAM104A,FGF9,FGL2,FHL1,FKBP5,FLRT2,FYN,FZD1,FZD4,G0S2,GADD45B,GATA4,GDF10,GGCT,Giot1/Zfp347,GJB2,GM2A,GREM1,GREM2,HAS2,HIF1A,HLA-A,HLA-DOB,HLA-DQA1,HPSE,ICAM1,ID2,IER3,IFI16,IGF1,IGFBP4,IL15RA,IL18R1,IL1RL1,IL33,IL7,INHA,INHBA,INHBB,IRS2,ITGA1,ITGA2,ITGA3,ITGA4,ITGA8,ITGB3,JUND,KCNT2,KHK,KLF4,LEPR,LIMCH1,LMCD1,LSS,MAF,MAPK14,MAPK3,MAT2A,mir-143,MMP19,MMP2,MVD,MVK,NFKBIB,NPR1,NPR3,NR0B2,NR1D2,NR2F1,NR4A1,NR5A2,NRP1,NTRK2,NTS,NUDT16,Oasl2,OXTR,PARD6G,PDE4D,PDGFC,PDLIM1,PFKFB3,PHLDA1,PLAT,PLPP3,PLXND1,POLA2,PPARG,PRICKLE2,PRKG2,PRKX,PRRG1,PTGES,PTGFR,PTGS2,PTX3,RAB11FIP3,RAPH1,RASSF2,RETN,RGS2,RGS20,RGS4,RPS6KB1,RUNX1,RUNX2,S100A10,S100A6,SACS,SCUBE1,SDC1,SDC4,SELENOP,SEMA3E,SFRP2,SFRP4,SLC20A1,SLC2A1,SLC4A4,SLCO2A1,SMAD6,SMAD9,SOCS3,SPAG1,SPP1,SREBF1,ST8SIA4,STAR,STEAP1,TFPI2,TIMP1,TM4SF1,TMEM164,TMOD1,TMX4,TNFAIP2,TNFAIP6,TNFRSF1B,TRIB1,TSHR,USP11,VCAM1,VCAN,VEGFC,WNT2,WNT4 | 1978 (22) |
| NPM1 | 3.40e-01 | transcription regulator | Inhibited | -6.30e+00 | NA | 0.0e+00 | ANO6,BAMBI,CAMK1D,Ccl2,CD47,CDH11,CEACAM1,COL12A1,COL16A1,COL5A1,COL7A1,CSF1,CSF1R,DLL1,ECM1,EDIL3,EGR1,EGR3,ENO2,ETS1,F3,FN1,FOXC2,FRK,HDAC9,HOXA5,HOXB5,ICAM1,IGFBP5,IL7,INHBA,JAG1,KLF10,KLF4,LAMC2,LOX,LOXL2,MMP2,MTSS1,MYADM,NAV3,NR4A1,NTRK2,NUAK1,P3H2,PCOLCE2,PDGFB,PLOD2,PLXNB3,PMEPA1,S1PR2,SDC4,SEMA5A,SERPINF2,SGK1,TGFBI,TNFRSF25,TRIB1,VEGFC,WNT5A,ZFP36L1 | 1527 (18) |
| tetradecanoylphorbol acetate | NA | chemical drug | Inhibited | -6.33e+00 | NA | 0.0e+00 | ABCA1,ABCA7,ADAM17,ADAMTS1,ADORA2A,AHR,ALCAM,ALDH1A3,ALOX12,AMIGO2,ANGPT2,ANXA1,AQP4,ARF1,ARG1,ARID3B,ASAH2,ATF3,ATP2A2,ATP2B4,AXL,B3GNT5,BCAR1,BCL2A1,BCL2L1,BCL3,BCL6,BDNF,BIRC3,BMP4,BTG1,BTG2,BTK,C3,C3AR1,C5AR1,CACNA1B,CALCR,CALCRL,CASP1,CAV1,CAV2,Ccl2,Ccl6,Ccl7,CCNA2,CCND1,CCND2,CCR3,CD226,CD276,CD28,CD36,CD44,CD48,CDH1,CDK5R1,CDKN1A,CIITA,CKAP4,CKM,CLDN1,CLEC12B,CMPK1,CREB1,CREM,CSF1,CSF1R,CSF2RA,CSF3R,CTSH,CXCL10,CXCL12,CXCL13,CXCR4,CYBA,CYBB,CYTH4,DAB2,DBP,DDIT4,DEK,DIO1,DMBT1,DUSP1,DUSP5,DUSP6,ECM1,EDF1,EEF1D,EGF,EGR1,EGR2,EGR3,EIF4EBP1,EIF6,EMP1,EPHA4,ERCC1,ERRFI1,ETS1,EZR,F3,FAAH,Fam13a,FBN1,FCER1G,FCGBP,FCGR1A,FGF2,FHL3,FKBP5,FOXC2,FOXP3,FZD1,GADD45B,GAP43,GCLC,GNB3,GPR34,GPR65,GRK5,GZMB,HAS2,HDC,HGF,HIF1A,HIVEP3,HLA-DRA,HNRNPC,HOPX,HOXA5,HPSE,HRAS,HRH1,HRH2,HSPA2,HTR2A,HTR7,ICAM1,ID2,IER3,IFI16,IGF1,IGFBP5,IGFBP6,IKBKE,IL17A,IL18R1,IL1RN,IL2RA,IL2RG,IL4I1,INHBA,INHBB,IP6K2,IRAK3,IRF1,IRF4,IRF8,ISG15,ITGA2,ITGA2B,ITGA5,ITGAD,ITGAL,ITGB2,ITGB3,ITM2A,JAG1,JAK3,JUND,KCNA5,KCNK2,KIT,KLF4,KLF5,KLF6,KLHL4,LBH,LEPR,LIPG,LOXL2,LPL,LYST,MAD1L1,MAF,MAOB,MAST4,MET,METTL7A,mir-133,MITF,MME,MMP14,MMP19,MMP2,MPZ,MRC1,MRPS12,MSR1,MYH7,MYL1,MYOG,NAB2,NCF1,NCOA7,NDFIP2,NEU1,NFAT5,NFIL3,NFKBIA,NFKBIB,NINJ1,NLRP3,NOX1,NPR3,NR4A1,NR4A2,NR5A1,NRP1,NTS,OCLN,OLR1,OSR2,PDE1C,PDE3B,PDE4D,PDK4,PDLIM7,PDPN,PEA15,PER1,PES1,PHGDH,PHLDA1,PKM,PKP3,PLAGL1,PLAT,PLD1,PLIN3,POLA2,POU2F2,PPARD,PPARG,PRDX1,PRKAR2B,PRKCB,PRKCD,PRKCE,PRKCQ,PRKCZ,PRKD1,PRKG2,PRKX,PTAFR,PTGES,PTGFR,PTGIR,PTGS2,PTPN6,PTPRB,PTPRC,PTPRF,PTPRJ,PTPRO,PTX3,RAB27A,Raet1d/Raet1e,RANBP1,RARA,RASGRP1,RBBP4,REL,RETN,RGN,RGS2,RNF7,RUNX1,RXRA,S100A10,SDC1,SDC4,SELE,SELP,SEMA3D,SERPINB9,SERPINE1,SFRP2,SFTPB,SGK1,SIGLEC8,SIK3,SKAP2,SKIDA1,SLAMF1,SLC16A1,SLC2A1,SLC39A8,SLC7A1,SMAD6,SNAI1,SNAI2,SNCA,SOCS1,SOCS3,SPARC,SPHK1,SPN,SPP1,SPRY4,ST3GAL1,ST6GAL1,ST8SIA4,STAR,STAT1,STAT5B,SUSD4,TBXAS1,Tchh,TEF,TEK,TEKT1,TEX9,TFPI2,TGFA,TGFB1,THBS1,THY1,TIMP1,TLR10,TLR2,TLR4,TLR5,TLR7,TLR8,TMOD2,TNFAIP6,TNFRSF10A,TNFRSF11B,TNFRSF1B,TNFRSF8,TPBG,TPO,TRPC6,TSFM,TTC9,TUBB6,TYMS,UGCG,USF2,VCAM1,VCAN,VEGFC,VIM,ZFP36 | 1654 (17) |
| TGFB1 | -1.02e+00 | growth factor | Inhibited | -6.50e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACKR2,ACSL3,ACSM3,ACTA1,ACTA2,ACTC1,ACTG2,ACVR1,ACVRL1,ADAM10,ADAM17,ADAM19,ADAMTS10,ADAMTS2,ADGRA1,ADGRG2,ADI1,ADIPOQ,ADRA2A,AHR,AIF1L,AK1,ALDH18A1,ALDOA,ALOX12,ALOX15,ALOX5,AMD1,ANKRD1,ANPEP,ANXA2,ANXA8/ANXA8L1,APLN,APLNR,ARF1,ARG1,ARHGAP19,ARHGAP24,ARHGAP27,ARHGEF2,ARID5B,ARNT2,ASGR2,ASNS,ATF3,ATP1B1,AUTS2,AXIN2,AXL,B2M,B3GALT2,BAMBI,BARD1,BCAT1,BCL2L1,BCL2L11,BCL3,BCL6,BCL9,BDH1,BDKRB2,BDNF,BGN,BHLHE40,BIN1,BIRC3,BMP1,BMP4,BTG1,BUB1,BUB1B,C1R,C2,C3,C3AR1,C4BPA,C5AR1,CALCR,Calm1 (includes others),CASP1,CASP3,CASP8,CAV1,CAV2,CBFA2T3,CBFB,Ccl2,CCL24,Ccl7,CCNA2,CCND1,CCND2,CCNE2,CCR1,CCR3,CCR5,CCRL2,CD101,CD200R1,CD226,CD28,CD34,CD36,CD44,CD74,CD83,CD86,CD9,CDC42EP3,CDC42EP4,CDH1,CDH11,CDH19,CDH2,CDK17,CDK2,CDK5R1,CDKN1A,CDKN2C,CEACAM1,CEBPD,CELF2,CENPF,CFB,CFH,CFI,CFL1,CHI3L1,CHMP3,CHST11,CHST3,CIITA,CITED2,CKM,CLDN1,CLIC4,CMTM5,CNN1,CNN3,COL11A1,COL12A1,COL16A1,COL18A1,COL1A1,COL2A1,COL3A1,COL4A6,COL5A1,COL6A3,COL7A1,COL8A1,CORO1C,COTL1,CPQ,CREB3L1,CRHR2,CRP,CSF1,CSF1R,CSPG4,CSRP1,CSRP2,CTSC,CTSH,CTSK,CTSS,CX3CL1,CX3CR1,CXADR,CXCL10,CXCL12,CXCL13,CXCR4,CXCR5,CYBA,CYBB,DAAM1,DAB2,DACH1,DACT1,DAD1,DAPK1,DBP,DCN,DDIT4,DDR2,DDX6,DEPTOR,DKC1,DKK3,DMTN,DNAJA1,DNAJB4,DOCK2,DPYSL2,DPYSL3,DUSP1,DYNLL1,E2F2,E2F5,ECM1,EDN1,EDNRB,EEF1A1,EGF,EGLN1,EGR1,EGR2,EGR3,EIF4EBP1,ELAVL1,ELF4,ELK3,ELMO1,ELN,ELOVL5,ENG,ENO2,ENO3,EPHB2,ESM1,ESPL1,ESRP2,ETS1,EXT1,EZH2,F13A1,F2R,F2RL1,F3,F5,FADS2,FAM107A,FAM110B,FAP,FBLN5,FBN1,FCER1G,FCGR1A,FCGR3A/FCGR3B,FGF1,FGF10,FGF2,FGF9,FGFR1,FHL1,FLI1,FLNA,FLRT1,FN1,FNDC5,FOXC1,FOXC2,FOXO1,FOXO3,FOXP3,FSCN1,FTL,FUBP1,FUT7,FXYD6,FYN,FZD1,FZD2,FZD5,GAD1,GADD45A,GADD45B,GAS7,GATM,GBP2,GCLC,GCNT1,GDF10,GDF6,GFAP,GFPT2,GGT6,GJB2,GLDN,GLI1,GLI2,GLUL,GNA13,GNAS,GNB4,GNB5,GNG2,GPD1,GPI,GREM1,GRHL1,Gsta4,GZMB,H6PD,HAPLN3,HAS2,HAS3,HCAR2,HDAC9,HEBP1,HGF,HHEX,HIF1A,HINT1,HK1,HLA-DQA1,HLA-DRA,HLTF,HNRNPC,HOOK1,HOPX,HOXB5,HRH2,HS6ST2,HSP90AA1,HSPA1A/HSPA1B,HTR2B,ICAM1,ID2,ID4,IDH1,IER3,IFI16,IFIH1,IGF1,IGFBP4,IGFBP5,IGFBP6,IGFBP7,IL10RA,IL17A,IL1R1,IL1RL1,IL1RN,IL2RA,IL2RB,IL33,INHA,INHBA,INHBB,INPP5D,IQCG,IRAK2,IRAK3,IRF1,IRF3,IRF8,IRS1,IRS2,ITGA1,ITGA11,ITGA2,ITGA3,ITGA4,ITGA5,ITGA6,ITGAE,ITGAL,ITGB2,ITGB3,ITGB7,ITGBL1,ITPK1,JAG1,JUND,KCNK1,KDELR2,KDELR3,KDR,KIT,KITLG,KLF10,KLF15,KLF3,KLF4,KLF9,KRT19,L1CAM,LAMC2,LAMP2,LASP1,LCAT,LEF1,LIMS1,LITAF,LOX,LOXL1,LOXL2,LPAR1,LPAR4,LPL,LSR,LTBP1,LTBP2,MAD1L1,MAF,MAN2B2,MAP1B,MAPK14,MAPK3,MAVS,MBOAT2,MCM7,ME2,MET,METRNL,MGAT3,MID1,mir-143,MITF,MKI67,MLXIP,MMP14,MMP2,MPV17L,MPZ,MRC1,MRC2,MS4A2,MSMO1,MSN,MSR1,MSTN,MTHFD2,MVD,MYBL1,MYCN,MYH7,MYL3,MYO10,MYOCD,MYOD1,MYOF,MYOG,NAB2,NCAM1,NCAPG,NCF1,NCF2,NDRG4,NEDD9,NET1,NFAT5,NFE2L2,NFKBIA,NLRP3,NMNAT2,NNMT,NOS1,NOTCH2,NOX4,NPAS2,NPR1,NPTXR,NR2F1,NR4A1,NR4A2,NR4A3,NRP1,NUAK1,NUP62,OCLN,OLR1,OSR2,OVOL2,P2RX6,P2RY1,P2RY6,PARK7,PCOLCE2,PDE4A,PDE4D,PDGFB,PDGFC,PDGFRA,PDK2,PDLIM4,PDLIM7,PDPN,PFDN1,PFKFB3,PGAM2,PGK1,PGRMC1,PHGDH,PI4K2B,PITX2,PKM,PLA1A,PLA2G4A,PLAGL1,PLAT,PLCB1,PLCL1,PLK1,PLK2,PLOD2,PLS3,PMEPA1,PMM1,PNMT,PPARD,PPARG,PPM1A,PPP1R13B,PPP1R3C,PRC1,PRDM1,PRDX4,PROM1,PSMC1,PTAFR,PTCHD1,PTGES,PTGS2,PTP4A3,PTPN6,PTPRC,PTX3,PYCARD,RAB31,RARA,RARG,RASGEF1B,RASGRF2,RASGRP1,RBL1,RBM19,RECK,RETN,RFC5,RFLNB,RGCC,RHOA,RND1,RNF152,RRAD,RSAD2,RSPO3,RUNX1,RUNX2,RXFP1,RXRA,S100A10,S100A11,S100A4,S100A6,S1PR2,SAR1B,SBNO2,Scd2,SDC1,SDC2,SDC4,SELE,SELENBP1,SELP,SEMA3A,SEMA3B,SEMA4A,SEMA7A,SERP1,SERPINE1,SERPINF1,SERPINF2,SERPINH1,SFRP1,SFTPB,SGK1,SHISA3,SHMT1,SIX1,SLA,SLAMF1,SLC12A4,SLC12A7,SLC16A2,SLC16A3,SLC1A4,SLC20A1,SLC2A1,SLC35A5,SLC39A8,SLC7A1,SLIT3,SMAD6,SMAD7,SMC2,SNAI1,SNAI2,SNTB2,SOCS1,SOCS3,SORD,SPARC,SPC25,SPEG,SPHK1,SPP1,SRSF3,SRSF4,ST3GAL6,STAR,STAT1,STAT5B,STAT6,STOML2,SUSD5,SVEP1,SYP,SYTL2,TACC2,TAGLN,TBX3,Tcf7,TGFA,TGFB1,TGFB1I1,TGFBI,THBD,THBS1,THBS2,THBS4,THY1,TIMP1,TLL1,TLR2,TLR4,TMEM17,TMOD3,TNC,TNFAIP6,TNFRSF10A,TNFRSF11B,TNNT2,TOP2A,TP63,Tpm1,TTC28,TTLL3,TUBA1A,TWIST1,TWIST2,TYMS,TYW3,UBE3A,UST,VAT1,VAT1L,VCAM1,VCAN,VEGFC,VIM,VPS28,VWF,WNK1,WNT10B,WNT11,WNT4,WNT5A,WNT9A,XPNPEP2,XYLT1,ZBTB14,ZEB2,ZFP36,ZFP36L2,ZFPM2 | 2027 (18) |
| RRAS2 | -5.60e-01 | enzyme | Inhibited | -6.68e+00 | bias | 0.0e+00 | ACER2,ACVRL1,ADAMTS5,AHR,ALCAM,C5AR1,CAV1,CD36,CD74,CDH1,CDH2,CDH3,CDH6,CFH,CLDN1,CLDN19,COL6A3,CSF1,DRAM1,EDIL3,EGR1,EGR3,ELF1,FSCN1,GCNT2,GFPT2,GPC3,HLA-DOB,IER3,IFI44L,IFITM3,ITGA5,ITGA8,JAG1,LAMC2,MDK,MPZL2,MSLN,NCAM1,NECTIN3,NID1,NR4A3,NRP1,OASL,PCDH7,PDGFC,PDGFRA,PLK2,RELN,ROCK1,ROS1,RSAD2,RTP4,SCN1B,SDC2,SELE,SEMA3E,SERPINB8,SERPINE1,THY1,USP18,VAV3,VCAN,VEGFC | 1207 (16) |
| tretinoin | NA | chemical drug | Inhibited | -6.71e+00 | NA | 0.0e+00 | A2M,AATK,ABCA1,ABCG1,ABHD5,ABI1,ABLIM1,ACKR2,ACSL1,ACTC1,Actn3,ADAM10,ADAM11,ADAMTS5,ADD3,ADGRE1,AHR,AKAP12,ALDH1A1,ALDH1A3,ALDH9A1,ALOX5,ANPEP,ANXA1,ANXA2,ANXA5,ANXA8/ANXA8L1,AP1S2,APBA2,APBB1IP,APCDD1,APLN,APLNR,APOD,ARG1,ARHGAP29,ASNS,ATF3,ATP2A2,ATP6V0A4,B3GALT1,BAMBI,BATF,BCL2A1,BCL2L1,BCL3,BCL6,BHLHE40,BIRC3,BMP15,BMP4,BTG1,BTG2,C3,C3AR1,C5AR1,CALB1,CALCR,Calm1 (includes others),CAMKK1,CASP1,CASP3,CBFB,Ccl2,CCL24,CCNA2,CCND1,CCND2,CCR1,CCR5,CCRL2,CD101,CD1D,CD244,CD300C,CD34,CD36,CD44,CD47,CD53,CD6,CD74,CD86,CD9,CD93,CDH1,CDH2,CDH6,CDK2,CDK5R1,CDK6,CDKN1A,CDKN2C,CEACAM1,CGGBP1,CHKA,CHL1,CHST10,CITED2,CLDN1,CLEC11A,Clec2d (includes others),CNR1,COL1A1,COL2A1,COL3A1,COL6A3,COTL1,CP,CREM,CSF1R,CSF3R,CSRNP1,CTSC,CTSK,CTSS,CX3CR1,CXCL10,CXCR4,CXCR5,CYBB,CYP26B1,CYP2S1,CYP4B1,CYP4F2,DAB2,DACT2,DAD1,DCN,DDAH2,DHRS9,DHX58,DKK3,DLC1,DLL1,DNASE1L3,DPP4,DPYSL3,DUOXA1,DUSP1,DYNLL1,E2F5,E2F7,EDN1,EEF1A1,EEF1D,EFS,EGR1,EIF3C,EIF4EBP1,EIF5B,EIF6,ELF4,ELN,ELOVL4,EMP3,ENOX1,EPHX1,ERCC1,ERRFI1,ETS1,ETV1,EYA2,F3,FBN2,FCER1G,FGF2,FGFR1,FGR,FLRT1,FN1,FOLR2,FOXC1,FOXO1,FOXO3,FOXP3,FZD10,G0S2,GAP43,GAS2,GAS7,GATA4,GBP4,GCA,GFAP,GFRA1,GLI1,GLI2,GM2A,GNA13,GNAS,GREM1,HAS2,HEY2,HIF1A,HIVEP3,HK1,HLA-A,HNRNPC,HOGA1,HOXA5,HOXB5,HOXC5,HOXD10,HOXD4,HOXD9,HSP90AA1,HSPA2,HUS1,ICAM1,ID2,IER3,IFI16,IFI44,IFI44L,IFIH1,IFIT1,IGF1,IGFBP4,IGFBP5,IGFBP6,IGFBP7,IL10RA,IL16,IL17A,IL1R1,IL4I1,INHBA,IRF1,IRF4,IRF8,IRS1,ISG15,ISLR,ITGA1,ITGA2,ITGA2B,ITGA4,ITGA6,ITGAE,ITGAL,ITGB2,ITGB3,ITGB7,JUND,KDR,KIF11,KIF23,KIT,KITLG,KLF10,KLF15,KLF4,KLF5,KLF9,KRT19,LAMA4,LAMP2,LBP,LEPR,LGALS1,LHX8,LOXL2,LRAT,LRRC25,LTB4R,LYN,MAD1L1,MAG,MALL,MAOB,MAP1B,MAP2,MAP3K10,MAP7,MAPK4,MARCKSL1,MDK,MEOX1,METTL7A,MIA,MID1,MMP14,MMP19,MMP28,MRAS,MSI1,MSLN,Mt1,MTHFD2,MYCN,MYF5,MYH7,MYL2,MYOCD,MYOD1,MYOG,NAA10,NAT2,NCAM1,NCF1,NCF2,NDUFV1,NECTIN3,NFATC3,NFE2L2,NFKBIB,NKX6-1,NLRC4,NMI,NR0B2,NR2F1,NR2F2,NRP1,NTHL1,NTN1,NTRK2,OAS3,OASL,OCLN,OGN,OPTN,PALLD,PAM,PAPPA2,PARP14,PARP9,PAX3,PDGFB,PDGFRA,PDLIM4,PENK,PFN1,PHLDA1,PIK3CG,PIK3R1,PITX2,PLA2G7,PLAT,PLCB1,PLD1,PLEK,PLEKHO2,PLK2,PLK3,PLP1,PLS3,Podxl,PPARD,PPARG,PPP3CA,PRAM1,PRKCB,PRKCD,PROM1,PTAFR,PTCH1,PTGES,PTGIS,PTGS2,PTP4A3,PTPRC,PTPRZ1,PTX3,RAB11B,RARA,RARG,RARRES1,RASGRF1,RBL1,RCBTB2,REC8,REL,RET,RFC2,RFLNB,RHOA,Rnf113a1,RNF213,RPL6,RPS16,RPS3,RTP4,RUNX1,RUNX2,RXRA,RXRG,S100A10,S100B,SACS,SALL4,SELP,SEMA6B,SEMA7A,SERPINB8,SERPINB9,SERPINE1,SERPING1,SFRP1,SFRP2,SFRP4,SFRP5,SFTPB,SIRPA,SIX1,SKAP2,SKP2,SLA,SLC16A1,SLC16A2,SLC25A15,SLC26A3,SLC38A2,SLCO2A1,SMAD6,SMAD7,SMAD9,SMOX,SMPD3,SOAT1,SOCS1,SOX6,SOX7,SP110,SPARC,SPP1,SREBF1,STAR,STARD10,STAT1,STAT6,STRA6,STT3A,TAL1,TFCP2L1,TGFB1,TGFBI,TGIF2,THBD,THBS1,TIMP1,TLE1,TLR2,TLR5,TMEM150A,TMSB10/TMSB4X,TNC,TNFAIP2,TNFAIP6,TNFRSF10A,TNFRSF11B,TNFRSF19,TNFRSF1B,TOP2A,TP63,TRPC3,TRPC6,TSPAN33,TWIST1,TYSND1,UBA7,Ubb,UBE2D3,UBE2L6,UBE3A,UCP3,USP18,VAV2,VCAM1,VEGFC,VIM,VWF,WIPF1,WNK1,WNT10B,WNT2B,WNT5A,WNT6,WSB1,XK,XPA,ZBTB16,ZEB2,ZNF536 | 1658 (17) |
| CSF2 | NA | cytokine | Inhibited | -6.91e+00 | NA | 0.0e+00 | ABCA1,ABCG1,ACP5,ACTA2,ADAM17,ADGRE5,ALOX5,ANXA1,ARG1,BCL2A1,BCL2L1,BCL2L11,BCL3,BIRC3,BUB1,BUB1B,C3,C5AR1,CARD11,CARD6,CASP1,CASP3,Ccl2,CCNA2,CCND1,CCND2,CCR1,CCR5,CCRL2,CD101,CD180,CD276,CD28,CD74,CD83,CD86,CDH1,CDKN1A,CDKN2C,CEACAM1,CFH,CHST11,CIITA,CISH,COL8A1,CREB1,CSF1,CSF1R,CSF2RA,CSF2RB,CTSC,CX3CR1,CXCL10,CXCR4,CYBB,CYP4F2,DNAJC5,DOK2,DUSP6,E2F7,E2F8,EDN1,EGR1,EGR2,EGR3,ELN,F2R,F2RL1,F3,FANCA,FBXO31,FCGR1A,FCGR2B,FOLR2,FOXP3,GADD45GIP1,GCH1,HAS2,HCAR2,HDC,HGF,HIF1A,ICAM1,ID2,IER3,IFITM3,IFNLR1,IGF1,IL16,IL1R1,IL1RL1,IL1RN,IL2RA,INHBA,INPP5D,IRAK3,IRF4,IRF5,ITGA4,ITGAE,ITGB3,KIF11,KNTC1,LAMP2,LCP1,LY75,MAT2A,MET,MKI67,MME,MMP14,MMP2,MRC1,NAB2,NCAM1,NET1,NFKBIA,NLRP3,NOX1,NR4A1,NR4A2,NR4A3,NRP1,NUAK2,OLR1,OSMR,PHGDH,PIK3CG,PIM3,PLD1,PLK1,PMP22,PPARG,PRC1,PRKAA1,PTGS2,RARA,RBBP4,REC8,RGCC,RIPK2,SCIMP,SERPINB9,SGK1,SGO1,SKA1,SLC1A5,SLC2A1,Slfn2,SMC2,SNTB1,SOCS1,SOCS3,SPC25,SPHK1,SPP1,SREBF1,STMN1,TGFB1,TGFBI,THBS1,TIFA,TLR2,TLR4,TLR5,TNFRSF1B,TNFRSF4,TNFSF8,TOP2A,UHRF1,UTP11,VTCN1,ZFP36,ZNF25 | 1211 (14) |
| Interferon alpha | NA | group | Inhibited | -7.27e+00 | NA | 0.0e+00 | ADAM19,ADAMTS1,ALDH18A1,ANKRD10,ANXA1,ANXA2,ANXA5,ASNS,ATF3,AUTS2,AXL,B2M,BCL2A1,BCL2L1,BCL3,BCL6,BCR,BMP4,BTG2,C3,C3AR1,CASP1,CASP3,CASP8,CAV1,CCNA2,CCND1,CCND2,CCR1,CCR3,CCR5,CD1D,CD83,CD86,CDH1,CDKN1A,CEACAM1,CELSR1,CIITA,CISH,CKAP4,CLIC2,CNP,COL1A1,COL7A1,CSF2RB,CTSS,CXCL10,CYP1B1,DDIT4,DHX58,DOCK10,DOCK2,DRAP1,DUSP6,DYNLT1,EDEM1,EFCAB6,EIF4EBP1,ENTPD1,EPSTI1,EZH2,F2R,F3,FCGR1A,FCGR2B,FKBP11,GBP2,GBP5,GCLC,GIMAP4,GLI1,GPX7,GZMB,HERC6,HLA-A,HSPA1A/HSPA1B,ICAM1,IFI16,IFI44,IFI44L,Ifi47,IFIH1,IFIT1,IFITM3,IFNLR1,IGFBP4,IKBKE,IL10RA,IL15RA,IL17RA,IL18R1,IL1R1,IL1RN,IL2RA,IL2RB,IL7,IRF1,IRF4,IRF5,IRF8,ISG15,ITGA11,ITGA4,KDELR3,KRT19,LOXL1,LTBP1,LTBP2,MARCKSL1,MCRS1,MMP2,MMP28,MSR1,MTHFD2,MX1,Mxra7,MYH7,MYLIP,MYOF,NABP1,NFIL3,NFKBIA,NMI,OAS3,Oasl2,PARP14,PARP9,PI4K2B,PLAT,PNPT1,PON3,PPM1K,PPP1R14B,PRC1,PRKCE,PTGES,PTGIS,PTGS2,PTPN6,RGS10,RNF213,RSAD2,RTP4,S100A6,SEC24A,SERPINB9,SGSM3,SHTN1,SLA,SLC1A5,SLFN13,Slfn2,SOCS1,SOCS3,SP110,SPRY4,ST6GAL1,STAT1,TACC3,TDRD7,TGFB1,TLR2,TLR4,TLR7,TLR8,TNFSF18,TPBG,TRIL,TSPAN8,TTC28,TUBA1A,TUBB,TUBB6,TYMS,UBA7,UBE2L6,UNC93B1,USP18,USP6NL,VCAM1,VCAN,VIM,ZC3HAV1 | 1122 (17) |
| TNF | -5.20e-01 | cytokine | Inhibited | -7.57e+00 | NA | 0.0e+00 | A2M,AATK,ABCA1,ABCC3,ABR,ACADS,ACKR2,ACKR3,ACP5,ACSL1,ACSL3,ACSL5,ACTA1,ACTA2,ADAM17,ADAMTS5,ADAMTS8,ADCY7,ADGRG6,ADIPOQ,ADORA2A,ADRB2,AKAP12,ALCAM,ALDH1A3,ALOX5,AMPD3,ANGPT2,ANKRD1,ANKRD55,ANPEP,ANXA1,APBA3,APLN,AQP7,ARG1,ARHGDIB,ARHGEF10,ARHGEF5,ARID5B,ARRDC3,ARSI,ATF3,ATP1A1,ATP2A2,ATP2B4,AXIN2,B2M,B4GALT1,BAMBI,BCKDHA,BCL2A1,BCL2L1,BCL2L11,BCL3,BCL6,BCR,BDKRB2,BDNF,BGN,BHLHE40,BIRC3,BMP3,BMP4,BPGM,BTG1,BTG2,BTG3,BTRC,BUB1B,C15orf48,C3,C3AR1,C5AR1,CA12,CALCR,CARD6,CASP1,Casp12,CASP3,CASP8,CAV1,CCDC80,Ccl2,CCL21,CCL24,Ccl6,Ccl7,CCND1,CCND2,CCR1,CCR3,CCR5,CCRL2,CD200,CD28,CD34,CD36,CD44,CD47,CD74,CD83,CD86,CDC42EP4,CDC42EP5,CDH1,CDH11,CDH2,CDH3,CDK2,CDK5R1,CDKN1A,CDKN2C,CDO1,CEBPD,CERS4,CERS6,CFB,CFL1,CHI3L1,CHRND,CHST11,CHST7,CIB2,CIITA,CISH,CITED2,CKM,CLDN1,CLEC11A,CLIC4,CMKLR1,CNN1,CNP,COL16A1,COL1A1,COL27A1,COL2A1,COL3A1,COL5A1,COL7A1,COLQ,COTL1,COX4I1,CP,CPA3,CREB1,CREM,CRP,CRYAB,CSF1,CSF1R,CSF2RB,CSGALNACT1,CST7,CTSC,CTSK,CTSS,CX3CL1,CX3CR1,CXCL10,CXCL12,CXCL13,CXCL16,CXCR4,CXCR5,CYBA,CYBB,CYP1B1,CYP26B1,CYP27A1,CYP7B1,CYTIP,CYYR1,DCHS1,DCN,DDIT4,DENND2D,DEPTOR,DIO1,DMBT1,DOCK8,DPP4,DUSP1,DUSP10,DUSP5,DUSP6,DVL1,ECH1,EDIL3,EDN1,EDNRB,EGLN1,EGLN2,EGR1,EGR2,EGR3,ELAVL1,ELK3,ELMO1,ELOVL7,EMCN,EMP1,EMP2,ENG,ENPP3,EPHB2,ERCC1,ESM1,ETS1,ETV5,EXOSC7,EXT1,F2RL1,F2RL3,F3,FABP1,FADD,FADS1,FARP2,FBXL2,FBXO32,FCER1G,FCGR2B,FCGRT,FGF10,FGF2,FGFR1,FN1,FOXC2,FOXO1,FOXP3,FRZB,FSCN1,FUT7,FYN,FZD5,G0S2,GAB1,GADD45A,GADD45B,GADD45G,GBP2,GBP4,GCH1,GCLC,GFAP,GFPT2,GLI1,GM2A,GNAI1,GNAI3,GNB4,GNG2,GPAM,GPD1,GPD2,GPR176,GPR88,GREM1,Gsta4,HAS2,HAS3,HDAC9,HDC,HGF,HIF1A,HLA-A,HLA-DRA,Hmgn2 (includes others),HMGN3,HSPA1A/HSPA1B,HUS1,ICAM1,IER3,IFI16,IFIH1,IFIT1,IFITM3,IGF1,IGFBP4,IGFBP5,IGFBP6,IKBKB,IKBKE,IL10RA,IL15RA,IL16,IL17A,IL17RA,IL17RD,IL18BP,IL18R1,IL1R1,IL1RL1,IL1RL2,IL1RN,IL2RA,IL33,IL34,IL4I1,IL7,INHA,INHBA,INPP5D,IRAK2,IRAK3,IRF1,IRF4,IRF5,IRF8,IRS1,IRS2,ISG15,ITGA1,ITGA10,ITGA2,ITGA4,ITGA5,ITGA6,ITGAL,ITGB2,ITGB3,ITGB7,JAG1,JUND,KCNH2,KDR,KIAA1671,KIT,KITLG,KLF10,KLF4,KLF5,KLF6,KLHL21,LAD1,LAMA3,LAMA4,LAMC2,LBP,LCAT,LGALS12,LGALS9B,LGR5,LITAF,LOX,LOXL2,LPAR6,LPL,LRG1,LRRC8D,LSS,LTB4R,LTBP2,LYN,MAFA,MAFF,MAGI1,MALL,MAN1C1,MAP2K4,MAP3K14,MAPK14,MARCKSL1,MAT2A,MEOX1,MEOX2,MET,METRNL,MFHAS1,MGST1,MGST2,MIA,MITF,MLKL,MMP14,MMP2,MMP28,MSLN,MSR1,MSTN,Mt1,MX1,MYH10,MYH7,MYOD1,MYOG,NCAM1,NCF1,NCF2,NCOR2,NEDD9,NET1,NFE2L2,NFKBIA,NFKBIB,NID1,NINJ1,NKD2,NKX6-1,NLRP3,NNMT,NOD2,NOS1,NOTCH4,NOX1,NOX4,NR0B2,NR4A1,NR4A2,NR4A3,NR5A1,NR5A2,NRARP,NRP1,NRROS,NTN1,NUAK1,NUAK2,OAS3,OASL,OCLN,OGN,OLFML2A,OLFML2B,OLR1,OPTN,OSMR,P2RX2,P2RY6,P3H2,PANX1,PARP14,PC,PCDH7,PDE1C,PDGFB,PDGFRA,PDIA4,PDPN,PENK,PHGDH,PHLDA1,PIK3C2B,PIK3CG,PIM3,PKM,PLA1A,PLA2G2A,PLA2G4A,PLA2G4E,PLA2G5,PLAT,PLIN1,PLIN4,PLK2,PLK3,PLOD2,PLP1,PLPP3,PLVAP,PPARD,PPARG,PPARGC1B,PPP1R3C,PPP5C,PRDM1,PRKCD,PRKDC,PRRG4,PTGES,PTGFR,PTGIS,PTGS2,PTPN12,PTPRC,PTX3,PYCARD,RAB32,RARA,RASGRF1,RASSF5,RCAN2,REL,RETN,RGCC,RGS14,RGS2,RGS20,RGS4,RGS7,RHOA,RIPK2,RIPK3,RNASE4,RND1,RND3,RPS11,RPS3,RPS6KB1,RRAD,RSAD2,Rtp3,RUNX1,RUNX2,RXRA,S100A10,S1PR2,SCNN1G,SCUBE1,SDC1,SDC2,SDC4,SELE,SELENOP,SELP,SEMA3C,SERPINB8,SERPINB9,SERPINE1,SERPINF1,SFRP1,SFTPB,SGK1,SH3TC2,SIRPA,SLC12A4,SLC15A3,SLC16A2,SLC1A3,SLC1A4,SLC20A1,SLC27A1,SLC2A1,SLC35B2,SLC39A8,SLC7A1,SLC7A8,SLC9A3,Slco1a4,SLCO2B1,Slfn2,SMAD7,SMO,SMPDL3B,SNAI1,SOAT1,SOCS1,SOCS3,SPARC,SPHK1,SPP1,SRA1,SREBF1,ST3GAL6,ST6GAL1,ST8SIA4,STAC,STAR,STAT1,STMN1,SUSD4,SYK,TAGLN,TBC1D8,TBXAS1,TDRD7,TEK,TERF2IP,TFPI2,TGFA,TGFB1,TGFB1I1,THBD,THBS1,THBS2,THBS3,THY1,TIAM2,TIFA,TIMP1,TINAGL1,TLR2,TLR4,TLR5,TLR7,TLR8,TM4SF1,TMC7,TMEM176B,TNC,TNFAIP2,TNFAIP6,TNFAIP8,TNFRSF10A,TNFRSF11B,TNFRSF1B,TNFRSF25,TNFRSF4,TNFRSF8,TNFSF8,TNNC1,TOX,TP63,TPD52L2,TPO,TPST1,TRADD,TRAF5,TRIM63,TRPC3,TRPC6,TST,TWIST1,TWIST2,UACA,UBQLN2,UCK1,UCN2,UCP3,UGCG,UTP11,VAV2,VAV3,VCAM1,VEGFC,VEGFD,VIM,VIPR2,VSIR,WLS,WNT10B,WNT5A,ZBTB11,ZFP36 | 1586 (17) |
| IFNG | NA | cytokine | Inhibited | -7.99e+00 | NA | 0.0e+00 | A2M,ABCA1,ABI1,ACTA2,ADAM17,ADAMTS8,ADAMTS9,ADCY7,ADGRA1,ADGRG2,ADIPOQ,ADORA2A,ADRA2A,AGPAT1,AHR,AIF1,AIF1L,ALDH1A3,ALOX12,ALOX15,ARAP2,ARFGAP3,ARG1,ARNT2,ASNS,ATF3,ATP1A1,ATP1B1,ATP2A2,AUTS2,B2M,BACH1,BATF,BCAN,BCL2A1,BCL2L1,BCL2L11,BCL3,BDNF,BIRC3,BRCA2,BTG1,BUB1,BUB1B,C15orf48,C1R,C2,C3,C5AR1,CALB1,CARD6,CASP1,Casp12,CASP3,CASP8,CAV1,Ccl2,Ccl6,Ccl7,CCNA2,CCND1,CCND2,CCR1,CCR3,CCR5,CCRL2,CD1D,CD200,CD276,CD36,CD44,CD74,CD83,CD86,CDC25B,CDH1,CDH2,CDK2,CDK5R1,CDKN1A,CEACAM1,CEBPD,CELSR1,CERS6,CFB,CFH,CHAC1,CHRND,CHST11,CHST3,CHST7,CIITA,CISH,CKMT1A/CKMT1B,CLIC4,CLIP2,CNR1,COL1A1,COL5A2,CORO1A,COX4I1,CP,CREM,CSF1,CSF1R,CSF2RB,CSK,CTSC,CTSH,CTSK,CTSS,CX3CL1,CX3CR1,CXADR,CXCL10,CXCL12,CXCL13,CXCL16,CXCR4,CYBA,CYBB,CYP27A1,CYTIP,DAPK1,DBP,DCN,DDR2,DIO1,DLL1,DNAJB7,DNASE1L3,DPP4,DTX3L,DUOX2,DUSP1,DUSP5,E2F2,E2F5,EDN1,EDNRB,EEF1A1,EFCAB6,EGF,EGR1,EGR2,EGR3,EIF2AK3,ELAVL1,ELN,ENDOD1,ENTPD1,ERAP1,ESM1,EXT1,F2R,F2RL1,F3,FAAH,FAM107A,FBLN1,FCER1G,FCGR1A,FCGR2B,FCGR3A/FCGR3B,FGF1,FGF2,FGL2,FHL2,FKBP5,FLRT2,FMNL2,FN1,FOXO1,FOXP3,FTL,FXN,FZD1,FZD2,GAD1,GADD45B,GBP2,GBP4,GBP5,GBP7,GCH1,GFAP,GGT5,GJA5,GJB2,GLDN,GLIPR2,GLUL,GNA13,GNAS,GNB4,GNB5,GNG11,GNG2,GZMB,H6PD,HAS2,HCAR2,HCK,HDAC9,HERC6,HIF1A,HLA-A,HLA-DOB,HLA-DQA1,HLA-DRA,Hmgn2 (includes others),Hnrnpa3,HOXD4,HSD17B4,HSP90AA1,HSPA1A/HSPA1B,ICAM1,ID2,IDH1,IER3,IFI16,IFI44,IFI44L,Ifi47,IFIH1,IFIT1,IFITM3,IGF1,IGFBP4,IKBKE,IKZF2,IL10RA,IL15RA,IL17A,IL17RA,IL18BP,IL18R1,IL1R1,IL1RL1,IL1RL2,IL1RN,IL2RA,IL2RB,IL4I1,IL7,INHBA,IRAK2,IRF1,IRF3,IRF4,IRF5,IRF8,IRS1,IRS2,ISG15,ITGA4,ITGA5,ITGA6,ITGAL,ITGB2,ITGB3,ITPK1,ITPKB,JAG1,JAK3,JUND,KDR,KIF23,KITLG,KLF10,KLF4,KLF6,KNL1,KRT19,LAMC2,LAT2,LCP2,Ldha/RGD1562690,LGALS9B,LIX1,LOX,LPAR4,LPL,LTB4R,LY75,LYN,LZTS1,MAF,MAFA,MAFF,MAN2A1,MAP2,MAP2K2,MAPK14,MARCKSL1,MAT2A,MAX,METRNL,MITF,MLKL,MMP2,MRAS,MRC1,MSR1,Mt1,MTHFD2,MTSS1,MX1,MYCN,MYH10,MYH7,MYOD1,MYOG,NCAM1,NCF2,NDRG4,NEDD9,NFKBIA,NFKBIB,NKX6-1,NLRP3,NMI,NOD2,NOS1,NOX1,NOX4,NR4A3,NR5A2,NRP1,NTN1,NTRK2,OAS3,OASL,Oasl2,OCLN,OLR1,OPTN,P2RY1,P2RY6,PAM,PANX1,PARP14,PARP9,PCDH17,Pcsk1,PCTP,PDE3B,PDGFB,PDGFC,PDK4,PEA15,PENK,PFKFB3,PHGDH,PHLDA1,PIK3C2G,PIM3,PKM,PLA2G2A,PLA2G5,PLA2G7,PLD1,PLEK,POLR2F,PPARD,PPARG,PPARGC1B,PPIA,PPP5C,PRDM1,PRKCD,PRKCQ,PRKG2,PROM1,PSMA4,PSMA6,PTAFR,PTGES,PTGS2,PTN,PTPN6,PTPRB,PTX3,QPRT,RAB12,RAB27A,RAB38,RAC2,RARRES1,RGCC,RGN,RIPK2,RSAD2,RTP4,RUNX2,S100A10,S1PR2,SBNO2,SCIMP,SCNN1G,SCUBE1,SDC1,SDC4,SELE,SELENOP,SELP,SEMA3C,SEMA4A,SEMA7A,SERP1,SERPINB9,SERPINE1,SERPING1,SERPINH1,SFRP1,SIX1,SKP2,SLAMF1,SLC15A3,SLC16A3,SLC1A3,SLC1A5,SLC2A1,SLC37A4,SLC3A1,SLC4A4,SLC9A3,Slfn2,SMAD7,SMPD3,SNAI1,SNAI2,SOAT1,SOCS1,SOCS3,SORT1,SP110,SPON1,SPP1,SREBF1,SSBP1,ST6GAL1,STAR,STAT1,STAT6,STX11,STX3,SUMO2,TBXAS1,TGFB1,THBS1,THEMIS2,THY1,TIMP1,TLR2,TLR4,TLR5,TLR7,TLR8,TMOD1,TNFAIP2,TNFAIP6,TNFRSF10A,TNFRSF11B,TNFRSF1B,TP63,TPH1,TPO,TRIL,TSHR,TSPAN33,TTC28,UBE2E1,UBE2L6,UNC5B,USP18,USP6NL,VCAM1,VEGFC,VIM,VSNL1,WNT5A,WNT9A,ZBTB16,ZEB2,ZFP36,ZNF638,ZNF81 | 1289 (14) |
| lipopolysaccharide | NA | chemical drug | Inhibited | -8.96e+00 | NA | 0.0e+00 | 9930111J21Rik1/Gm12185,ABCA1,ABCC3,ABCC4,ABCC5,ABCG1,ACAD8,ACADL,ACKR3,ACP5,ACSL1,ACTA1,ACTA2,ACTC1,ACTN4,ACVR1,ADAM17,ADAMTS1,ADAMTS5,ADGRE1,ADIPOQ,ADORA2A,ADRA2A,ADRB2,ADRM1,AEN,AHR,AIF1,AK4,ALCAM,ALDH1A1,ALDOA,ALOX12,ALOX15,ALOX5,AMPD3,ANGPT2,ANK2,ANKRD1,ANXA1,ANXA2,ANXA5,AOAH,AOX1,APLNR,APOBEC1,AQP4,AQP7,ARFGAP3,ARG1,ARHGEF3,ARRDC3,ASAP3,ATF3,ATP1A1,ATP2A2,ATP8B2,ATRX,AVEN,AXIN2,AXL,B2M,BAMBI,BANK1,BATF,BCL11B,BCL2A1,BCL2L1,BCL2L11,BCL3,BCL6,BCL9,BDNF,BGN,BIRC3,BMP4,BRI3,BTG1,BTK,BUB1,C1R,C3,C3AR1,C5AR1,CACNA1D,CALCR,CALCRL,Calm1 (includes others),CARD11,CARD6,CARHSP1,CASP1,Casp12,CASP3,CASP8,CAV1,CBFA2T3,Ccl2,CCL21,CCL24,Ccl7,CCND1,CCND2,CCNE2,CCNI,CCR1,CCR3,CCR5,CCRL2,CD180,CD1D,CD200,CD22,CD276,CD28,CD300LD,CD300LF,CD36,CD37,CD44,CD47,CD48,CD53,CD74,CD83,CD86,CD9,CDC42EP3,CDC42EP4,CDH1,CDH11,CDH2,CDK5R1,CDK6,CDKN1A,CEACAM1,CEBPD,CFB,CFH,CHD7,CHI3L1,CHST3,CHST7,CIITA,CISH,CITED2,CKAP4,CLDN1,CLDN3,CLEC11A,CLIC4,CNNM2,CNP,COL12A1,COL1A1,COL3A1,COL4A6,COL5A1,COL5A2,COPS7A,CORO1A,COX4I1,COX6A2,CP,CREB5,CREM,CRHR2,CRP,CRYAB,CSF1,CSF1R,CSF2RA,CSF2RB,CSF3R,CSK,CSPG4,CSRP1,CST7,CSTB,CTSC,CTSK,CTSS,CUX2,CX3CL1,CX3CR1,CXADR,CXCL10,CXCL12,CXCL13,CXCL14,CXCL16,CXCR4,CXCR5,CYBA,CYBB,CYP27A1,CYP4F2,CYP7B1,CYTIP,DCN,DDIT4,DDX27,DDX6,DHDH,DHX58,DKK3,DLL1,DMBT1,DNAJB1,DNASE1L3,DOCK10,DOCK8,DRAM1,DSE,DTX3L,DUSP1,DUSP5,EDA2R,EDEM1,EDEM3,EDN1,EGR1,EGR2,EGR3,EIF2AK3,ELAVL1,ELF1,ELK3,ELL2,ELN,EMB,EMCN,ENO2,ENTPD1,EPSTI1,ERCC1,ERP44,ESCO2,Esrra,ETV5,EXT1,EZH2,F2R,F2RL1,F3,FAAH,FBN1,FBXO32,FCER1G,FCGR1A,FCGR2B,FCGR3A/FCGR3B,FCGRT,Fcrls,FGF2,FGL2,FLI1,FMNL2,FN1,Fnbp1l,FOXC2,FOXO1,Foxp1,FOXP3,FSCN1,FSTL1,FYN,FZD1,FZR1,G0S2,G6PD,GAB1,GADD45A,GADD45B,GADD45G,GAP43,GAPDH,GBE1,GBP2,GBP4,GBP5,GCA,GCH1,GCLC,GCNT2,GFAP,GFPT2,GGCT,GIMAP7,GJA5,GJB2,GLIS2,GLRB,GLRX,GNA13,GNAI3,GOLGA4,GPD1,GPD2,GPI,GPM6A,GPR183,GPR34,GPSM1,GREM1,GSR,GZMB,H2-T24,HACD2,HCAR2,HCK,HCLS1,HDAC9,HDC,HEG1,HERPUD1,HGF,HHEX,HIF1A,HIVEP3,HK1,HLA-A,HLA-DOB,HLA-DQA1,Hmgn2 (includes others),HOMER1,HOPX,HSD17B8,HSF2,HSP90AA1,HSPA1A/HSPA1B,HUS1,ICAM1,ID2,IDH1,IER3,IER5,IFI16,IFI44,IFI44L,Ifi47,IFIH1,IFIT1,IFITM3,IGF1,IGFBP4,IGFBP5,IKBKE,IL10RA,IL10RB,IL15RA,IL16,IL17A,IL17RA,IL18BP,IL18R1,IL1R1,IL1RL2,IL1RN,IL2RA,IL2RB,IL2RG,IL33,IL4I1,IL7,INHBA,INHBB,INPP5D,IQGAP1,IRAK2,IRAK3,IRF1,IRF3,IRF4,IRF5,IRF8,ISG15,ITGA2,ITGA3,ITGA4,ITGA5,ITGA8,ITGA9,ITGAE,ITGAL,ITGB2,ITGB7,ITM2C,JAG1,JAK3,JAZF1,JUND,KCNJ15,KCNK1,KCNMB4,KDELR2,KDM3A,KDR,KIF11,KIF23,KIF5C,KIT,KITLG,KLF10,KLF3,KLF4,KLF6,KNTC1,LAD1,LASP1,LBP,LCP2,LDB2,LGALS1,LIMS1,LIPG,LITAF,LOX,LPAR1,LPIN1,LPL,LTB4R,LY75,LY86,LYN,MAF,MAFF,MAP1LC3B,MAP1S,MAP2K2,MAP2K4,MAP3K6,MARCKSL1,MAX,MB,MC2R,MDH1,MET,METRNL,MGAT2,MGST2,MID1,MIER2,mir-143,MKI67,MLKL,MME,MMP14,MMP2,MOB1A,MRAS,MRC1,MSN,MSR1,Mt1,MTHFD2,MTSS1,MX1,MYCN,MYH10,MYH14,MYH7,MYL2,MYL3,NCAPG2,NCF1,NCF2,NCF4,NCOA7,NDUFV2,NEK6,NFAT5,NFE2L2,NFIL3,NFKBIA,NFKBIB,NID1,NKD1,NLRP3,NNMT,NOD2,NOS1,NOTCH2,NOTCH4,NOX1,NOX4,NR0B2,NR2F2,NR4A1,NR4A2,NR4A3,NR5A2,NRARP,NRP1,NRP2,NSFL1C,NTN1,NTS,NUCB1,NUP93,OAF,OAS3,OASL,Oasl2,OCLN,OGN,OGT,OLFML2B,OLFML3,OLR1,OPTN,OSBPL3,OSMR,OTUD1,OXCT1,P2RY12,P2RY6,PANX1,PARK7,PARP14,PARP9,PAWR,PC,PCDH7,PCOLCE,PCOLCE2,PDE10A,PDE1C,PDE3B,PDGFB,PDIA4,PDK4,PDPN,PENK,PFKFB3,PGK1,PHLDA1,PHLDB2,PIK3CG,PIK3R1,PKM,PKP3,PLA2G2A,PLA2G2D,PLA2G4A,PLA2G5,PLA2G7,PLAT,PLD1,PLEK,PLEKHA4,PLIN4,PLK1,PLK2,PLK3,PLPP5,PMEPA1,Podxl,POLA1,PON3,POU2F2,PPARD,PPARG,PPARGC1B,PPIA,PPM1A,PPP1R13B,PRC1,PRDM1,PRDX1,PRDX5,PRKAA1,PRKAA2,PRKCB,PRKCQ,PRKCZ,PROS1,PRR5,PRRG4,PSMA4,PSMA6,PSMB1,PSMC1,PTAFR,PTCH1,PTGES,PTGFR,PTGS2,PTPN6,PTPN7,PTPRB,PTPRC,PTPRO,PTX3,PYCARD,RAB27A,RALGDS,RARA,RASGEF1B,RASGRP1,RASSF2,REL,RETN,RFLNB,RGCC,RGS2,RGS7,RHBDF2,RHPN2,RIPK2,RND3,RNF213,ROCK1,RPS2,RSAD2,RTP4,RUNX1,RUNX2,RXRA,RXRG,S1PR2,SAMSN1,SAP30,SASH3,Scd2,SCIMP,SCNN1G,SCUBE1,SDC1,SDC4,SEC24D,SELE,SELENOP,SELP,SEMA3A,SERPINB9,SERPINE1,SERPINF1,SERPINF2,SERPINH1,SESN1,SFTPB,SFXN1,SIAH2,SIGIRR,SIPA1,SIRPA,SLAMF1,SLC15A3,SLC16A2,SLC16A3,SLC1A5,SLC25A34,SLC27A1,SLC2A1,SLC38A2,SLC39A10,SLC39A6,SLC39A8,SLC44A1,SLC4A10,SLC9A1,SLC9A3,Slco1a4,SLCO2A1,SLFN13,Slfn2,SMAD7,SMC2,SNCAIP,SNTB2,SOCS1,SOCS3,SOCS7,SP140,SPARC,SPC25,SPHK1,SPP1,SREBF1,SRSF1,SSBP1,SSBP3,ST6GAL1,STAR,STAT1,STAT6,STMN1,STX11,STX4,SUMO2,SWAP70,SYP,TACC3,Tcf7,TEK,TES,TFDP2,TFPI2,TGFA,TGFB1,THBD,THBS1,THBS2,THEMIS2,THY1,TIMP1,TIPARP,TKT,TLR10,Tlr13,TLR2,TLR4,TLR5,TLR7,TLR8,TM4SF1,TMEM170A,TMEM176A,TMEM52,TMEM67,TMSB10/TMSB4X,TNC,TNFAIP2,TNFAIP6,TNFAIP8,TNFRSF19,TNFRSF1B,TNFRSF4,TNFSF18,TNFSF8,TNK2,TNNC1,TNNT2,TOP2A,TOR3A,TP53BP2,TP63,TPBG,TPST1,TRADD,TRIB1,TRIL,TRIM63,TTC14,TUBB,TWF2,Ubb,UBE2D3,UCN,UCP3,UHRF1,USP18,UTRN,VCAM1,VCAN,VEGFC,VIM,VIPR2,VSIR,VTI1B,VWF,WEE1,WNT5A,YWHAQ,ZBTB16,ZC3H12C,ZC3HAV1,ZFC3H1,ZFP36,ZFP36L2,ZNF281,ZNF800 | 1736 (16) |
| AGT | -1.70e-01 | growth factor | Inhibited | -9.24e+00 | NA | 0.0e+00 | A3GALT2,ACTA1,ACTA2,ACTC1,ADAM17,ADAMTS2,ADAMTS5,ADAMTS8,ADD3,ADGRE1,ADH1C,ADIPOQ,Aff2,ALDH1A3,ALOX12,ALOX15,ALOX5,ANGPT2,ANO1,ANXA1,APLN,ARFGAP1,ARG1,ARHGEF9,ASAH2,ATF3,ATN1,ATP1A1,ATP1B1,ATP2A2,ATP6AP2,ATP6V0A4,BACH1,BDKRB2,BDNF,BGN,BHLHE40,BMP1,BTK,BUB1,C1QTNF6,C1QTNF7,C3,C5AR1,Calm1 (includes others),CASP3,CASP8,CAV1,CCBE1,CCDC80,Ccl2,Ccl7,CCND1,CCND2,CCNE2,CCR5,CD109,CD300C,CD36,CD44,CD86,CDK2,CDKN1A,CFI,CGREF1,CILP,CIT,CLEC4M,CNN1,CNR1,COL12A1,COL16A1,COL18A1,COL1A1,COL3A1,COL4A6,COL5A1,COL5A2,COL6A3,COL8A1,COX4I1,CP,CREB1,CREB5,CREM,CRP,CSPG4,CSRP2,CTHRC1,CTSK,CTSS,CX3CR1,CXADR,CXCL10,CXCL12,CYBA,CYBB,DAB2,DDAH2,DKK3,DMBT1,DUSP1,E2F2,EBP,ECM1,EDARADD,EDN1,EDNRB,EFNA5,EGR1,ELN,ENG,ENPEP,ERRFI1,ESM1,ETS1,ETV1,ETV5,F2R,F3,FBLN5,FCGR1A,FCGR2B,FGF16,FGF2,FGR,FHOD3,FIBIN,FKBP5,FN1,FOXC2,FOXO3,FRZB,FZD1,GAB1,GADD45GIP1,GAP43,GAS2,GATA4,GCH1,GDF6,GLDN,GLI2,GREM1,GRK5,HAS2,HCLS1,HGF,HHIPL1,HIF1A,HLF,HOXB5,HSPA1A/HSPA1B,ICAM1,IDH1,IFI16,IGF1,IGFBP4,IGFBP5,IGFBP7,IL17A,IL18R1,IL2RA,INHBB,IRF6,IRS1,IRS2,ITGA1,ITGA10,ITGA2,ITGA3,ITGA5,ITGA8,ITGB2,ITGB3,ITGB4,ITGB7,ITPKB,JAG1,KDR,KITLG,KLF15,KLF4,KLF5,L1CAM,LAMP2,LEPR,LIMD2,LIPG,LOX,LOXL1,LOXL2,LOXL4,LSS,LTBP1,LTBP2,LUM,MAP1LC3A,MAP2,MATN2,MGST1,MMP2,MSMO1,MSR1,MYBL1,MYH10,MYH6,MYH7,MYO7A,NAV1,NCF1,NCF2,NCOR2,NFE2L2,NFKBIA,NLRP3,NMNAT2,NOS1,NOTCH4,NOVA1,NOX1,NOX4,NPR1,NPR3,NR4A1,NR4A2,OCLN,OLFML2A,OLR1,OTUD1,PALLD,PAWR,PCDH17,PCSK5,PDGFB,PDGFC,PDGFD,PDGFRA,PDGFRL,PFN1,PIK3R1,PIR,PLXNA4,POLE3,PPARG,PPP1R3C,PREX1,PROM1,PTGFR,PTGIS,PTGS2,PTN,PTPRC,PTPRZ1,RASGRF1,RASGRP1,RBL1,Rcan1,RGMA,RGS2,RHOA,RIPK3,ROCK1,RUNX1,SCUBE3,SDC1,SELE,SEMA3D,SERPINE1,SFRP2,SFRP4,SGK1,SLC10A6,SLC1A1,SLC2A1,SLC9A1,SLC9A3,SLIT3,SMAD7,SMOC1,SNCA,SOCS1,SOCS3,SOX6,SPARC,SPP1,STAR,SUSD5,SVEP1,TACC3,TAGLN2,TBX18,TBX5,Tcf7,TEF,TGFA,TGFB1,TGFB1I1,TGFBI,THBD,THBS1,THBS2,TIMM9,TIMP1,TNC,TNFRSF11B,TNFRSF19,TNFRSF1B,TNFRSF4,TOP2A,TRPC6,TTC7A,UGCG,UHRF1,UNC5B,VCAM1,VEGFC,VIM,WIPF3,YBX2,ZEB2,ZFP36 | 2005 (19) |
| GNA15 | -8.90e-01 | enzyme | NA | NA | NA | 0.0e+00 | ACKR3,ACTA2,ADD3,AKAP12,ARG1,BMP3,BMP4,C3,CAV2,Ccl2,CDO1,CDS1,CEBPD,CP,CRYAB,DAB2,FBLN5,FHL1,FHL2,GADD45A,GBP2,GDA,GLUL,HSD3B7,IL1RN,LBP,MAP2,MAT2A,MGST1,MGST2,Mt1,NOX1,NOX4,NPR3,OLR1,Omd,PAWR,PDLIM1,PLAT,PRKAA2,PRRX2,PRSS35,PTGS2,RAPGEF4,RGS2,SELENBP1,SLC7A1,SORBS2,TAGLN,THBD,TIMP1,UGDH,UNC5B,VCAN,ZFP36L1 | 872 (14) |
| GNA14 | 1.40e-01 | enzyme | NA | NA | NA | 0.0e+00 | ADAMTS1,AKAP12,ANKRD1,ANPEP,ARG1,ATF3,BMP4,BTG2,Clec2d (includes others),CNN1,CREM,CSPG4,CX3CL1,DUSP5,FCGR3A/FCGR3B,GADD45A,GBP2,Giot1/Zfp347,HAS2,IL1RN,KCNK2,KCNK6,KLF6,MEOX2,MGST1,NEU1,NFIL3,NPR3,NR4A1,NR4A2,OLR1,PHLDA1,PLAT,PTGS2,SELENBP1,SGK1,SPHK1,STAT1,TNFAIP6,ZFP36L1 | 872 (14) |
| PRKAG3 | 1.75e+00 | kinase | NA | NA | NA | 0.0e+00 | ABCA1,ACKR3,ACVR1,AMD1,ANKRD1,ANXA8/ANXA8L1,APBB3,ATP1B1,ATP6V1A,BTG2,CD36,CD93,CELF2,CLCN3,CSGALNACT2,CYP27A1,DDIT4L,DUSP10,EGR1,ELL2,ENOX2,FGFR1,FTL,FXYD6,GADD45G,GBE1,GLRX,GOLM1,GPX3,H2AC18/H2AC19,IGFBP5,ITGA6,KDM2B,KLF4,LMCD1,MAFA,MAGIX,MAT2A,METTL7A,MTERF2,MYOD1,NEU2,NOS1,OXCT1,PAM,PLIN3,POLE4,PPP1R14B,PRPF6,RASD2,RGCC,RNF128,RPL22,Scd2,SLC2A1,SLC4A3,SORD,SREBF1,TMCC2,TSPAN8,WNK2,WNT4,ZEB2,ZFP36 | NA |
| ATN1 | 8.10e-01 | transcription regulator | NA | NA | NA | 0.0e+00 | ARHGEF28,ATP1A1,ATP1B1,ATP1B2,BCL6,BDNF,BHLHE40,BMP1,BMP3,BTG3,CBFB,CDH11,CNR1,CSNK1D,DBP,DPYSL3,EBF1,ENO2,ETV1,FGF1,GAD1,GAS7,GRK5,H2AC18/H2AC19,IFI16,IGFBP5,KCNA1,KCNA2,KCNK3,LTBP2,MARCKSL1,MAX,NAB2,NEFL,NR2F1,NSG2,PCTP,PENK,PRKCD,PTPRF,PVALB,RAB2A,SMC2,SOX10,SPP1,SPTBN2,STMN1,STX4,TM4SF1,TUBB,TYRO3,VSNL1 | NA |
| BSCL2 | 5.10e-01 | other | NA | NA | NA | 0.0e+00 | AATK,ACSL1,ADIPOQ,ANKRD1,Ccl2,Ccl7,CCND1,CD36,CD74,GPD1,GREM1,GRIA2,HACD2,IER3,IGFBP5,IL1RL1,IL33,LGALS12,LPIN1,LPL,MARK1,NAT8L,PC,PKP3,PNPLA2,PPARG,PPARGC1B,PTGS2,PYGL,RETN,RSAD2,TIMP1 | 1075 (12) |
| Sos | NA | group | NA | NA | NA | 0.0e+00 | ALDH1A3,APLN,B4GALT1,CAMK2D,CD44,CERS4,CHI3L1,COBLL1,COL16A1,DAP,ENAH,ESM1,FBLIM1,FLRT2,FMN1,GAS2,GATA4,GM2A,GSR,HBA1/HBA2,HOOK1,IGFBP5,IRS2,ITGA6,KLF6,LAMA3,MET,MGST1,MMRN1,MPZL2,MYH6,NDUFS7,NET1,NFE2L2,NFIL3,PDPN,PFN1,PHLDA1,PKN1,PLD1,PLK2,Pmaip1,PMEPA1,PRPF4B,PTGS2,PTPN12,PTPRZ1,RAP1GAP,RBBP4,RFNG,RGMA,RUNX1,SEMA3B,SEMA3E,SEMA6D,SIRPA,SMAD7,STK3,STMN1,STX11,TGFB1,TIPARP,TNMD,Tpm1,UGCG,UTRN | 1256 (16) |
| MAFA | 1.71e+00 | transcription regulator | NA | NA | NA | 0.0e+00 | ABCC8,ADCY7,ALDH1A3,ANKRD1,AQP4,BCL2A1,CACNA1E,CACNA1G,CAMK2A,Ccl2,CCL24,Ccl7,CD53,CDKN1A,CHRNA4,CSF2RB,CXCL12,CXCR4,CYSLTR1,DLK1,ENG,ERBB3,FGF2,FOXO1,GNAL,HRH1,HRH2,HTR2A,HTR7,ICAM1,ID2,IGFBP5,IL18R1,IL2RB,IL7,KCNJ11,LARS2,MAPK14,MID1,NFATC4,NOS1,OXTR,PDGFRA,PRKCD,PTAFR,PTGER3,PTGFR,SERPINE1,SLC8A3,TBX3,TNFRSF19,ZNF189 | 936 (9) |
| PLK1 | 8.30e-01 | kinase | NA | NA | NA | 0.0e+00 | ACKR3,ACTA2,ANKRD1,BCL2L11,CDH1,CDH2,CDKN1A,DTX3L,EEF1E1,ELAVL1,IER3,IFI16,PARP9,PIK3R1,PLK1,Ptprv,PYCARD,SMAD7,SNAI1,SNAI2,TGFB1,TGFB1I1,TGFBI,THBS1,TNFAIP6,VIM | 1388 (18) |
| SBDS | 6.50e-01 | other | NA | NA | NA | 0.0e+00 | CALB1,CHAC1,COL14A1,COL27A1,CPLX1,CRYM,DNAJB1,DPYD,EGR1,ERBB3,FA2H,FBXO32,GADD45B,GAP43,IFI16,IGFBP7,KIF1A,LGR5,MAFF,NTS,PCDH7,PLAGL1,PPP1R1A,PTBP3,PTPRO,RAC2,RBP7,RGS4,SNAI2,SORCS1,SPP1,TERF2IP,TNC,UBE2QL1,ZNRF1 | 673 (7) |
| RBM20 | -1.60e-01 | other | NA | NA | NA | 0.0e+00 | ANKRD1,ATP1B1,ATP2A2,BICC1,CACNA1G,CARHSP1,CAV1,CELF2,CLIC4,CNOT6,CPEB3,CSDE1,DAPK1,DDX6,DPYSL3,EIF3C,FHOD3,FREM2,HOPX,KHDRBS3,KLC1,MICU1,MMP2,MSI2,MYH6,MYH7,MYL3,MYOCD,NEB,PKD2,PRKDC,RPL28,RPS3,RYR1,SCN5A,SMYD2,SPARC,Srsf5,TNNC1,ZFP36L1 | NA |
| discodermolide | NA | chemical drug | NA | NA | NA | 0.0e+00 | BARD1,BRCA2,CDK2,CDKN1A,E2F2,EIF4EBP1,ESPL1,FANCB,GADD45A,KIF11,KIF23,PLK1,PLK4,PRC1,RBL1,RFC2,RFC5,SMC2,TOP2A,WEE1 | 1080 (7) |
| RSL3 | NA | chemical reagent | NA | NA | NA | 0.0e+00 | ADPRHL1,CACNA1E,CASP1,CD74,CDH1,CXCR4,DMTN,FBLN1,LONRF1,MDK,MGAT3,NLRP3,PLA1A,SYK,WIPF3 | NA |
| RNA polymerase II | NA | complex | NA | NA | NA | 0.0e+00 | ACTC1,ADIPOQ,AGPAT2,ARG1,ARID5A,ASNS,B2M,C3,CA12,CCND2,CCNE2,CD83,CDH1,CDH11,CDKN1A,CDO1,CIITA,CISH,CKM,CLDN3,CSF1,CXCR4,CXCR5,CYP1B1,DCTPP1,DIO1,DUSP1,FOXC1,FOXC2,GADD45A,GADD45B,GAPDH,GATA4,GBP2,GBP7,HAS2,HLA-DQA1,HNRNPU,HSPA1A/HSPA1B,ICAM1,Ifi47,IGF1,IL17A,IL1RN,IL2RA,ITGA5,KCNF1,KCNJ9,KITLG,L1CAM,MAL,MAP2K2,MICOS10,MMP2,Mt1,MYCN,MYOG,NFKBIA,NR5A2,OASL,PBX3,PPARG,PPARGC1B,PTGS2,Pzp,RALGDS,RBBP4,RDM1,RND3,RPS3,RUNX2,SOCS3,SPP1,TGFB1,THBS2,TNNT1,TNNT2,TOP2A,UBC | 1485 (17) |
| RRP1B | -5.10e-01 | transcription regulator | NA | NA | NA | 0.0e+00 | ADCY7,ANAPC13,BRCA2,CASP3,CCNA2,CCND1,CDKN1A,DNAJC12,ESPL1,FANCB,FEN1,FOXO1,FZD6,GADD45A,HSP90AA1,ITGB2,KIF11,MRAS,NUP210,PDGFC,PLK1,PRKCD,PRKD1,RABIF,RARA,RARG,RBL1,RPL14,RPL22,RPL37A,RPL6,RPS10,RPS3,SMAD6,SPP1,TGFB1,TOP2A,VEGFC | NA |
| beta-galactosidase | NA | group | NA | NA | NA | 0.0e+00 | ABLIM1,ALCAM,COL3A1,COL5A2,COL6A3,CXCL12,EFNA5,EGR2,EZR,FLRT2,MYH10,SEMA3D,SLIT3,WNT5A | NA |
| Histone h4 | NA | group | NA | NA | NA | 0.0e+00 | ACTA1,ADIPOQ,AKAP12,BTG3,CCND1,CD1D,CDKN1A,CIITA,CXCL10,DIO1,G6PD,GADD45B,GRIA2,HAS2,HPSE,ICAM1,IL2RA,IRF1,KIF1A,KIF5C,LEF1,MAD1L1,Mt1,NEDD4L,NEURL1,NTRK2,OAS3,PPARG,PREX1,PTGS2,RASGRP1,RBL1,RUNX2,SELE,SFRP1,SOCS3,SPHK1,SPP1,SREBF1,STAR,TACC2,TAGLN,TBX5,TNFRSF4,TYMS,VCAM1 | 1255 (18) |
| PC-SPES | NA | chemical drug | NA | NA | NA | 0.0e+00 | ALOX5,ANXA1,B2M,CCNA2,CCND1,CD9,CDC25B,CDK2,CDKN1A,CDKN2C,COL16A1,COL1A1,DAD1,DNAJB1,FTL,GAPDH,GPI,HERPUD1,HMGN3,HSD17B4,HSP90AA1,IRF1,MAN2A1,MGST1,MYH3,OAZ2,OGT,PEA15,SELENBP1,TMPRSS2,TMSB10/TMSB4X,TYMS,VIM | NA |
| TTN | NA | kinase | NA | NA | NA | 0.0e+00 | ANKRD2,ATP2A2,Calm1 (includes others),CRYAB,FHL1,FHL2,TRIM63 | NA |
| RHOJ | -5.30e-01 | enzyme | NA | NA | NA | 0.0e+00 | ACTG1,ADIPOQ,AKAP12,ANXA1,ATP2A2,CALU,CAV1,CCNI,PLAT,PTN,RND3 | NA |
| ETS | NA | group | NA | NA | NA | 0.0e+00 | C3AR1,CCND1,CHI3L1,DAB2,EGR1,ENG,ICAM1,ITGA2B,JAK3,SERPINE1,TIMP1,VWF | NA |
| FAM3B | -1.71e+00 | cytokine | NA | NA | NA | 0.0e+00 | CAV1,CDKN1A,DCN,FN1,GAS2,IER3,IGFBP4,ITGA5,KRT19,LGALS1,PTN,SPARC | 860 (7) |
| FOLR1 | -1.00e-01 | transporter | NA | NA | NA | 0.0e+00 | ACTN4,ACVR1,ADH1C,AP1S2,AQP4,ARHGDIB,ASPA,BCAT2,BIRC3,CAV1,CD9,CELF2,CENPK,COQ7,CSTF1,DUSP6,GLRX,GPAM,LPAR1,MDK,NPHP1,PFN1,PPARG,RPS24,S100A4,SIX5,SMC2,SORD,ST3GAL6,TAGLN2,TYMS | NA |
| GNB2 | 4.00e-01 | enzyme | NA | NA | NA | 0.0e+00 | AHR,CD83,CDKN1A,CNNM2,CREM,CYTH1,CYTIP,DUSP1,FBXO31,IER3,MC2R,NR4A1,NR4A2,PLK2,PRDM1,THBD | 896 (15) |
| RDH10 | -1.11e+00 | enzyme | NA | NA | NA | 0.0e+00 | CLDN3,LEF1,RDH5,SFRP1,SFRP2,SFRP5 | NA |
| ingenol mebutate | NA | chemical drug | NA | NA | NA | 0.0e+00 | BCL2L1,PRKCB,PRKCD,PRKCE,PRKD1,SNCA | 1151 (16) |
| ADRA1B | 4.50e-01 | G-protein coupled receptor | NA | NA | NA | 0.0e+00 | ACTA1,APBA3,BDNF,CCND1,CDKN1A,CEBPD,COL3A1,CREM,CSRP2,DDAH1,DUSP1,EGR1,EGR2,FN1,LOX,NR4A1,NR4A2,PPP3CA,Scd2 | 1386 (20) |
| ADRA1D | -1.70e-01 | G-protein coupled receptor | NA | NA | NA | 0.0e+00 | APBA3,BDNF,CDK2,CEBPD,COL3A1,CREM,CSRP2,DDAH1,DUSP1,EGR1,EGR2,FN1,LOX,NR4A1,NR4A2,POLA1,POLA2,PPP3CA,Scd2 | 1483 (20) |
| ADRA1A | -1.00e-02 | G-protein coupled receptor | NA | NA | NA | 0.0e+00 | APBA3,BDNF,CDK2,CEBPD,COL3A1,CREM,CSRP2,DDAH1,DUSP1,EGR1,EGR2,FN1,LOX,NR4A1,NR4A2,POLA1,POLA2,PPP3CA,Scd2,SNAI1 | 1114 (18) |
| PLN | NA | transporter | NA | NA | NA | 0.0e+00 | ADAM17,AK1,ALDOA,ANXA2,ATP1A1,CALU,DLL1,EZR,GCGR,HEY2,HRAS,KCNJ12,MYH3,MYH7,MYL2,PGAM2,PGK1,PRKCB,PRKCE,PRKCQ,SPTB,VCP,VIM | 1143 (17) |
| NKX3-1 | -4.00e-01 | transcription regulator | NA | NA | NA | 0.0e+00 | BTG2,CA12,CA3,CDH1,CX3CR1,CXCL13,ETS1,FKBP5,FOXO3,PIK3R1,PRKCB,PTP4A2,PTPRC,RUNX1,SDC1,SDC4,SOAT1,STEAP1,TMPRSS2,TWIST1,VAV3 | 703 (7) |
| Pln | -5.00e-01 | other | NA | NA | NA | 0.0e+00 | ACTA1,AK1,ALDOA,ANXA2,ATP1A1,CALU,EZR,GCGR,HRAS,KCNJ12,MYH3,MYH7,MYL2,PGAM2,PGK1,PRKCB,PRKCE,PRKCQ,SPTB,VCP,VIM | NA |
| SETBP1 | -4.90e-01 | transcription regulator | NA | NA | NA | 0.0e+00 | BARD1,BCL11A,BCL3,BCL6,BRCA2,BUB1B,CARD11,CCND1,CD74,CDKN2C,CRTC1,ETV5,FLI1,IKBKB,JAK3,KDR,KNL1,MAP2K2,N4BP2,NR4A3,PDGFB,RARA,RPL22,SIX1,TNC,XPA | 1084 (7) |
| GNB1 | -2.70e-01 | enzyme | NA | NA | NA | 0.0e+00 | AHR,CD83,CDKN1A,CNNM2,CREM,CYTH1,CYTIP,DUSP1,F2R,FBXO31,IER3,NR4A1,NR4A2,PLK2,PRDM1,THBD | 1008 (19) |
| CDK2AP1 | 4.10e-01 | other | NA | NA | NA | 0.0e+00 | BTRC,CCND2,CDK2,DAAM1,DIXDC1,DVL1,FBXW4,FZD1,FZD5,NKD1,PITX2,PPARD,SFRP2,WNT16,WNT2B,WNT5A,WNT6 | 1233 (14) |
| RNASEH2A | 1.10e-01 | enzyme | NA | NA | NA | 0.0e+00 | ACKR3,CXCL10,GBP2,IFI16,IFI44,IFIH1,IFITM3,IRF1,IRF5,ISG15,NFKBIA,NMI,OASL,PARP9,PTGS2,RSAD2,TLR2,TLR4,USP18 | NA |
| MFN1 | -1.90e-01 | enzyme | NA | NA | NA | 0.0e+00 | ALDOA,CDH1,ENO2,GAPDH,GPI,LDHB,PKM,SLC2A1 | 858 (7) |
| AK1 | 6.60e-01 | kinase | NA | NA | NA | 0.0e+00 | ACADL,AK1,CKMT1A/CKMT1B,ENO3,GAPDH,MYF5,MYL2,PKM | 661 (6) |
| n-nitrosomethylbenzylamine | NA | chemical toxicant | NA | NA | NA | 0.0e+00 | ACTN4,ANXA2,AOX1,BUB1,CACNA1B,CCND1,CD44,CIB2,CLDN1,DUSP5,FTSJ3,GREM1,Gsta4,HSP90AA1,IDH1,INHBB,KLF10,KLF5,LAMP2,LEPR,MGST1,MSN,MYO10,PECR,PHGDH,PLK3,PLS3,PPP3CA,PRKG2,PSMA6,PTGS2,RABIF,RragB,SDC1,SPSB3,TGFA,TUBB6,TXNL1,UBE3D | NA |
| TCL1A | NA | transcription regulator | NA | NA | NA | 0.0e+00 | APOBEC1,C3AR1,CCR1,CD244,CD300LD,CPA3,CSF3R,CTSC,CTSE,CTSH,CTSS,CYBB,FCER1G,FCGR2B,FKBP5,GPNMB,IL17RA,ITGB2,MMP19,MSR1,MYO5A,NEU1,PTPRO,SEMA7A,SLC15A3,TLR7,TNFAIP2,UTRN | 775 (7) |
| omeprazole | NA | chemical drug | NA | NA | NA | 0.0e+00 | A2M,ABCC3,ADORA2A,BCL2L1,CD36,CDKN1A,CELF2,CNN1,CXCL12,CXCR4,EGR1,HDAC7,HDC,ITGA6,NDRG4,NTRK2,PRRX2,SYK | 906 (14) |
| KCNE3 | 2.00e-02 | ion channel | NA | NA | NA | 0.0e+00 | BCAT1,CHKA,CHL1,CISH,CSRNP1,CXCL13,DUSP6,EPN3,HSPA1A/HSPA1B,IRF4,KLF4,NFIL3,NR4A1,NR4A2,PER1,PHLDA1,PIK3C2G,PLK3,PLP1,PRDM1,PTGS2,SLC2A5,TNFAIP6 | NA |
| NR2F1-AS1 | NA | other | NA | NA | NA | 0.0e+00 | CCND1,CDH1,CDH2,NR2F1,VIM | NA |
| Integrin alpha 4 beta 1 | NA | complex | NA | NA | NA | 0.0e+00 | BCL2L1,F3,KIT,MMP14,PDGFB | 1260 (18) |
| diacylglycerol | NA | chemical - endogenous mammalian | NA | NA | NA | 0.0e+00 | CD36,FABP1,IL2RA,PRKCB,PRKCD,PRKCE,PRKCQ,RASGRP1 | 1189 (19) |
| black raspberry extract | NA | chemical drug | NA | NA | NA | 0.0e+00 | ACTN4,ANXA2,AOX1,BUB1,CACNA1B,CD44,CIB2,CLDN1,DUSP5,FTSJ3,GREM1,HSP90AA1,INHBB,KLF10,KLF5,LAMP2,LEPR,MSN,MYO10,PECR,PHGDH,PLK3,PLS3,PPP3CA,PRKG2,PSMA6,RragB,SDC1,SPSB3,TGFA,TUBB6,TXNL1,UBE3D | NA |
| MYBPC3 | -1.68e+00 | other | NA | NA | NA | 0.0e+00 | ATP2A2,Ccl2,CXCL10,MYBPC2 | NA |
| ACKR1 | NA | G-protein coupled receptor | NA | NA | NA | 0.0e+00 | BDNF,CITED2,ICAM1,IFI16,MYO5A,NINJ1,SELE,TBC1D8,TNFAIP2,VCAM1 | 1154 (14) |
| acyline | NA | biologic drug | NA | NA | NA | 0.0e+00 | BCL6,DUSP1,EEF1A1,EEF1E1,EGR1,GADD45B,GADD45G,NR4A1,OCLN,PIM3,RGS2,RPL17,RPL23,RPL28,RPL35,RPL6,RPS10,RPS11,RPS15,RPS15A,RPS16,RPS18,RPS2,RPS24,SLC16A3,SLC1A4,SLC38A1,SLC7A1,STAR,TBX3,ZBTB16 | 250 (3) |
| benazepril | NA | chemical drug | NA | NA | NA | 0.0e+00 | ACTA2,CDK2,CDKN1A,EDN1,OCLN,TGFB1 | NA |
| INPP5F | -8.40e-01 | phosphatase | NA | NA | NA | 0.0e+00 | CCND2,CDK17,CITED2,INHBA,KLHDC3,MAX,PHLDA1,PLK3,POLE3,RASSF2,TUBA1A,TUBB4A | NA |
| ZFPM1 | 4.50e-01 | transcription regulator | NA | NA | NA | 0.0e+00 | ALOX5,ANXA5,CNN3,CPA3,HEBP1,IKZF2,IL10RB,IL1R1,IL2RG,IRAK3,ITGA2B,ITPKB,KLF6,KLHL6,Mcpt4,MFHAS1,MS4A2,NRARP,PRELID2,PTGER3,SELP,SH2D4A,SLA,XK | 777 (10) |
| RCE1 | 5.00e-02 | peptidase | NA | NA | NA | 0.0e+00 | ACTN4,B2M,Ccl2,CRYAB,CXCL12,FBN1,FSTL1,HS6ST2,LMNB2,MGST1,PRRX2,S100A13,SLIT3,TGFBI,THBS2 | 1265 (10) |
| S-allyl-L-cysteine | NA | chemical - endogenous non-mammalian | NA | NA | NA | 0.0e+00 | ACTA2,CASP3,CDH1,PTGS2,SREBF1 | 1352 (19) |
| SMYD1 | 1.01e+00 | transcription regulator | NA | NA | NA | 0.0e+00 | ACADL,ACO2,AGL,BDH1,IDH3A,IDH3G,NDUFAB1,Ndufs5,NDUFV1,NT5C2,OXCT1,PKM,PYGL,PYGM,RXRA,TKT,UBC,UQCR11 | NA |
| LMNB1 | -3.90e-01 | other | NA | NA | NA | 0.0e+00 | ACTN4,B2M,Ccl2,CRYAB,CXCL12,DHCR7,ELOVL7,FBN1,FSTL1,HS6ST2,LMNB2,MGST1,MSMO1,PRRX2,S100A13,SLIT3,TGFBI,THBS2 | 525 (7) |
| ATXN3 | -4.00e-01 | peptidase | NA | NA | NA | 0.0e+00 | CREB1,CXCL12,IFIT1,IL1RL1,ISG15,MMP2,UBE3A | NA |
| fluvoxamine | NA | chemical drug | NA | NA | NA | 0.0e+00 | ACKR4,ADIPOQ,CCR1,CCR5,CD37,GAPDH,HTR2A,HTR7,ITPKB,NR4A2,RGS7,TFPI2 | NA |
| HNRNPL | 6.30e-01 | other | NA | NA | NA | 0.0e+00 | AXL,CEACAM1,GPT2,PTPRC | NA |
| COL11A1 | -2.34e+00 | other | NA | NA | NA | 0.0e+00 | ACTA2,COL11A1,DDR2,FAP | 369 (7) |
| RAC2 | -1.24e+00 | enzyme | NA | NA | NA | 0.0e+00 | ALDOA,ANXA1,BCL2L1,CCR5,CD244,CD74,CDH2,EGR2,FHL2,GCSAM,Mcpt4,NR4A1,PKM,PMP22,RUNX2,S100A6,TKT | 1338 (19) |
| NSD1 | -1.80e-01 | transcription regulator | NA | NA | NA | 0.0e+00 | AVPI1,BLOC1S2,BMP4,DLK1,FOXP3,IRAK3,KLF6,ZFP36L1 | NA |
| NRG2 | 1.55e+00 | growth factor | NA | NA | NA | 0.0e+00 | BIN1,CASP3,EDN1,EEF1A1,EGR1,ELOA,FSCN2,GAD1,IER3,IRF3,NR4A1,NR4A3,NR5A1,PFKFB1,PHKG1,PRKG2,SART3,TNFRSF25,TOB2,USF2 | 929 (7) |
| IDH2 | 2.00e-01 | enzyme | NA | NA | NA | 0.0e+00 | ADIPOQ,BTG2,CDH1,CLDN3,EGR1,FN1,HIF1A,HINT1,JUND,PEBP1,PPARG,PPIA,SRSF3,VIM,ZEB2 | 983 (12) |
| GON4L | 1.50e-01 | transcription regulator | NA | NA | NA | 0.0e+00 | CCNA2,CCND1,CCND2,E2F2,MKI67,RBL1,SKP2 | 321 (6) |
| TFCP2L1 | -8.40e-01 | transcription regulator | NA | NA | NA | 0.0e+00 | B3GNT7,ESRRB,GRHL1,KLF4,POLE4,SIRPA | 517 (6) |
| S100P | NA | other | NA | NA | NA | 0.0e+00 | CCND1,CFL1,COTL1,KRT19,S100A6,SLC2A5 | 578 (7) |
| pargyline | NA | chemical drug | NA | NA | NA | 0.0e+00 | CDKN1A,GFAP,HIF1A,MAP2,NOS1,PVALB | 1299 (12) |
| mechlorethamine | NA | chemical drug | NA | NA | NA | 0.0e+00 | ATF3,DUOX2,ID2,NFE2L2,PIK3R3 | NA |
| ciclopirox olamine | NA | chemical drug | NA | NA | NA | 0.0e+00 | AXIN2,BCL2L1,CDK2,CDKN1A,HIF1A | 1006 (7) |
| DPTIP | NA | chemical reagent | NA | NA | NA | 0.0e+00 | CX3CL1,CXCL10,VCAM1 | NA |
| narciclasine | NA | chemical - endogenous non-mammalian | NA | NA | NA | 0.0e+00 | ICAM1,SELE,VCAM1 | 957 (9) |
| YAP1-TEAD inhibitor peptide 17 | NA | chemical reagent | NA | NA | NA | 0.0e+00 | CDH1,CDH2,VIM | NA |
| FKHR | NA | group | NA | NA | NA | 0.0e+00 | A2M,CCND1,VCAM1 | NA |
| MIR100HG | NA | other | NA | NA | NA | 0.0e+00 | FN1,SERPINE1,SNAI1 | 678 (9) |
| Mir100hg | NA | other | NA | NA | NA | 0.0e+00 | CDH1,CDH2,VIM | NA |
| DENND5B | -2.70e-01 | other | NA | NA | NA | 0.0e+00 | CD36,PNPLA3,PPARG | NA |
| GPC6 | -6.30e-01 | transmembrane receptor | NA | NA | NA | 0.0e+00 | CCND1,GLI1,PTCH1 | 1051 (13) |
| PSMD14 | 2.00e-01 | peptidase | NA | NA | NA | 0.0e+00 | BCL2L11,BCL3,CCND1 | 1226 (12) |
| PTPN23 | 2.90e-01 | phosphatase | NA | NA | NA | 0.0e+00 | CDH2,SNAI1,VIM | NA |
| defibrotide | NA | biologic drug | NA | NA | NA | 0.0e+00 | F3,PLAT,SERPINE1 | NA |
| macitentan | NA | chemical drug | NA | NA | NA | 0.0e+00 | CDH1,CDH2,VIM | 1010 (11) |
| SEMA4C | -3.60e-01 | other | NA | NA | NA | 0.0e+00 | SNAI1,SNAI2,TWIST1 | 561 (7) |
| MPRIP | -1.90e-01 | other | NA | NA | NA | 0.0e+00 | RHOA,ROCK1,TLR4 | 890 (7) |
| RRAD | -1.89e+00 | enzyme | NA | NA | NA | 0.0e+00 | ATP2A2,CCND1,LPL | NA |
| EMP2 | -1.02e+00 | other | NA | NA | NA | 0.0e+00 | CAV1,ITGA5,ITGA6 | NA |
| DDX6 | -8.50e-01 | enzyme | NA | NA | NA | 0.0e+00 | LPIN1,mir-143,PPARG | NA |
| PABPN1 | 4.00e-02 | enzyme | NA | NA | NA | 0.0e+00 | MYOD1,MYOG,SREBF1 | NA |
| riociguat | NA | chemical drug | NA | NA | NA | 0.0e+00 | SERPINE1,SPP1,TIMP1 | 541 (7) |
| EEF1D | 9.90e-01 | translation regulator | NA | NA | NA | 0.0e+00 | CDH1,COL2A1,ITGA4 | NA |
| SOX13 | 3.50e-01 | transcription regulator | NA | NA | NA | 0.0e+00 | MET,SNAI2,WNT2 | NA |
| ostarine | NA | chemical drug | NA | NA | NA | 0.0e+00 | AMD1,IGF1,MSTN | NA |
| MFSD8 | NA | other | NA | NA | NA | 0.0e+00 | AIF1,GFAP,PFKFB3 | NA |
| WWP1 | 4.70e-01 | enzyme | NA | NA | NA | 0.0e+00 | KLF5,PRKAA2,TP63 | NA |
| SLC2A5 | 1.07e+00 | transporter | NA | NA | NA | 0.0e+00 | SLC26A3,SLC2A5,SLC9A3 | NA |
| KCNQ4 | 3.60e-01 | ion channel | NA | NA | NA | 0.0e+00 | MYOG,PAX3,TNNT1 | NA |
| SYF2 | 3.10e-01 | other | NA | NA | NA | 0.0e+00 | CDKN1A,POLA1,RBL1 | NA |
| IFT20 | -2.00e-01 | other | NA | NA | NA | 0.0e+00 | GLI1,GLI2,PDGFRA | 813 (10) |
| SETD3 | 4.90e-01 | enzyme | NA | NA | NA | 0.0e+00 | CKM,MYF6,MYOG | NA |
| TRMT13 | -2.00e-01 | other | NA | NA | NA | 0.0e+00 | CDH1,CDH2,VIM | NA |
| CYP2C9 | -1.40e-01 | enzyme | NA | NA | NA | 0.0e+00 | CCND1,DUSP1,HBA1/HBA2 | 571 (7) |
| EXOC7 | NA | transporter | NA | NA | NA | 0.0e+00 | SNAI1,SNCA,ZEB2 | NA |
| HNRNPF | -2.70e-01 | other | NA | NA | NA | 0.0e+00 | LPIN1,NFE2L2,PPARG | NA |
| SKF-83959 | NA | chemical reagent | NA | NA | NA | 0.0e+00 | BDNF,FGF2,MAP2 | 623 (7) |
| amifostine | NA | chemical drug | NA | NA | NA | 0.0e+00 | CASP3,PTGES,PTGS2 | NA |
| DL-threo-dihydrosphingosine | NA | chemical - kinase inhibitor | NA | NA | NA | 0.0e+00 | RARA,RXRA,SPHK1 | NA |
| etodolac | NA | chemical drug | NA | NA | NA | 0.0e+00 | CD36,CDH1,THBS1 | 633 (7) |
| ethyl-3-trifluoromethylbenzyl-alpha-ketoglutarate | NA | chemical reagent | NA | NA | NA | 0.0e+00 | CA9,HIF1A,SLC2A1 | NA |
| ethyl gallate | NA | chemical - endogenous non-mammalian | NA | NA | NA | 0.0e+00 | ICAM1,SELE,VCAM1 | NA |
| TTI-101 | NA | chemical drug | NA | NA | NA | 0.0e+00 | ACTA2,HIF1A,SERPINE1 | 702 (7) |
| menin-MLL inhibitor 2 | NA | chemical reagent | NA | NA | NA | 0.0e+00 | ABCA1,ABCG1,SREBF1 | NA |
| C66 | NA | chemical reagent | NA | NA | NA | 0.0e+00 | Ccl2,ICAM1,VCAM1 | 1042 (13) |
| NSOP00313 | NA | chemical reagent | NA | NA | NA | 0.0e+00 | ACTA2,COL1A1,PPARG | NA |
| mizoribine | NA | chemical drug | NA | NA | NA | 0.0e+00 | CCND1,CDK2,SGK1 | NA |
| GPD1 | 1.17e+00 | enzyme | NA | NA | NA | 0.0e+00 | ABCC4,Akr1b7,ANXA2,Aox3,ASNS,BCL6,C6,CCND1,CD36,CGREF1,CHRNA4,CXCL13,CYP39A1,CYP7B1,FADS3,GADD45A,GBP4,GPAT3,GPCPD1,GPD2,PFKFB3,PI4K2B,PRIMA1,RARRES1,SUSD4,TTC39C | NA |
| ICMT | 1.20e-01 | enzyme | NA | NA | NA | 1.0e-02 | ACTN4,Ccl2,CDKN1A,CRYAB,FSTL1,GNAT1,LMNB2,RHOA,S100A13,SLIT3,TGFBI,THBS2 | 1381 (17) |
| NRXN1 | -9.00e-02 | transporter | NA | NA | NA | 1.0e-02 | CD47,COL4A6,CXCL12,FBLN5,FLRT2,GFAP,MMRN1,NKX6-1,SLC1A3,TGFB1,THBS1,TNC | 863 (7) |
| POLR2A | 4.60e-01 | enzyme | NA | NA | NA | 1.0e-02 | ANO1,BCL2L1,CAV1,CCNA2,CCND1,CDK2,CDKN1A,CXCR4,EGR2,GAPDH,GATA4,MAGI1,MYOD1,NFKBIA,SELE,SGK1,STAR,TMPRSS2,UHMK1,VIM | 1203 (13) |
| telapristone acetate | NA | chemical drug | NA | NA | NA | 1.0e-02 | ACSL1,BUB1,CCNA2,CENPF,KIF11,NOTCH2,SPC25,TOP2A | 824 (8) |
| NFIB | -3.50e-01 | transcription regulator | NA | NA | NA | 1.0e-02 | ADAMTSL4,CACNA2D2,CDK18,CREB5,CYP4B1,EYA1,FHOD3,GFRA1,LOX,LZTS1,NCAM1,PLEKHF1,SLC16A14,TNFSF18,WHRN | NA |
| SP2 | 4.90e-01 | transcription regulator | NA | NA | NA | 1.0e-02 | CCND1,CDKN1A,CEACAM1,MAT2A,PRKCD,SERPINE1,SERPINH1 | NA |
| SLC25A13 | NA | transporter | NA | NA | NA | 1.0e-02 | ABCC4,Akr1b7,ANXA2,Aox3,ASNS,BCL6,C6,CCND1,CD36,CGREF1,CHRNA4,CXCL13,CYP39A1,CYP7B1,FADS3,GADD45A,GBP4,GPAT3,GPCPD1,GPD2,PFKFB3,PI4K2B,PRIMA1,RARRES1,SUSD4,TTC39C | NA |
| CCKBR | -3.00e-02 | G-protein coupled receptor | NA | NA | NA | 1.0e-02 | ADIPOQ,APLN,CDH2,HIF1A,KRT19,MAPK3,RETN,SPARC | 1236 (13) |
| OVA-8 | NA | chemical reagent | NA | NA | NA | 1.0e-02 | BCL2L1,CISH,CSNK2B,DKC1,EIF6,GADD45B,IL2RA,IL2RB,NFKBIA,NHP2,POP5,TCOF1,XPO1 | NA |
| SWI-SNF | NA | complex | NA | NA | NA | 1.0e-02 | MET,PLK1,PPARG,SELE | 1035 (16) |
| ZDHHC2 | -1.60e+00 | enzyme | NA | NA | NA | 1.0e-02 | CD9,CDH1,IL7,VIM | NA |
| SLC38A4-AS1 | NA | other | NA | NA | NA | 1.0e-02 | CD9,RORB,SEMA3D,VAT1L | NA |
| TFPI | -8.00e-02 | other | NA | NA | NA | 1.0e-02 | CASP3,CDKN1A,F3,ITGA2 | 1156 (14) |
| NACA | 2.50e-01 | transcription regulator | NA | NA | NA | 1.0e-02 | COL1A1,DMP1,MYOG,PDPN | NA |
| H2BC17 | 2.90e-01 | other | NA | NA | NA | 1.0e-02 | ADAM19,CST7,DOCK11,ITGBL1,MEGF9,MRPL21,PIK3CG,SLC36A1,SPTLC3,TMX4,ZFHX4 | NA |
| CHI3L1 | 6.80e-01 | enzyme | NA | NA | NA | 1.0e-02 | BHLHE40,CDH1,CDH11,COL16A1,EMP1,IGFBP5,NNMT,SERPINE1,TGIF2,TNC | 1331 (15) |
| SPTAN1 | -3.20e-01 | other | NA | NA | NA | 1.0e-02 | CDKN1A,ITGA3,ITGA5,ITGB3,SPTB | NA |
| MYL2 | -1.77e+00 | other | NA | NA | NA | 1.0e-02 | ACTN2,ACTN4,ANXA1,ANXA2,ANXA5,CASQ2,CSRP3,HK1,HNRNPL,LGALS1,PYGM,RYR1 | NA |
| HOXD13 | NA | transcription regulator | NA | NA | NA | 1.0e-02 | ACTN2,COL5A2,FBN2,FN1,HOXD9,RET,TNC,TWIST1 | NA |
| ZNF202 | -5.20e-01 | transcription regulator | NA | NA | NA | 1.0e-02 | ABCA1,ABCG1,LCAT,LPL,PLP1,PLTP,PNMT,ZFP36 | NA |
| UQCC3 | 1.07e+00 | other | NA | NA | NA | 1.0e-02 | ALDOA,ATP11C,ATP1A1,ATP1B1,ATP2A2,ATP2B4,ATP6AP2,ATP6V0B,ATP6V1A,ATP6V1E1,ATP6V1F,COX14,COX4I1,COX6B1,ENO2,ENO3,GAPDH,GPI,HIF1A,HK1,NDUFA1,NDUFA7,NDUFAB1,NDUFAF2,NDUFB3,NDUFB9,NDUFC1,NDUFC2,NDUFS7,NDUFV1,NDUFV2,PGK1,PKM,UQCR10,UQCR11 | NA |
| PRR11 | -4.20e-01 | other | NA | NA | NA | 1.0e-02 | CDH1,CDH2,CDK2,CDK6,CDKN1A,VIM | NA |
| EHD1 | 2.80e-01 | other | NA | NA | NA | 1.0e-02 | CCND1,CDH1,CDH2,IKBKB,SNAI1,VIM | NA |
| RAD21L1 | -3.00e-02 | other | NA | NA | NA | 2.0e-02 | DUSP5,DUSP6,ERBB3,MAP3K14,MRNIP,MYADM,OPTN,PEA15,PLK2,TUBB6 | NA |
| STAG3 | -1.40e-01 | other | NA | NA | NA | 2.0e-02 | DUSP5,DUSP6,ERBB3,MAP3K14,MRNIP,MYADM,OPTN,PEA15,PLK2,TUBB6 | NA |
| TAF6 | -3.50e-01 | transcription regulator | NA | NA | NA | 2.0e-02 | ATF3,BCL11B,CDKN1A,GADD45A,GAPDH,HLA-DRA,IRF1,LSMEM1,SRSF3,SRSF4 | NA |
| THAP11 | 2.20e-01 | transcription regulator | NA | NA | NA | 2.0e-02 | ATL3,COTL1,LCP1,LOX,MDH1 | NA |
| ATF1 | -4.20e-01 | transcription regulator | NA | NA | NA | 2.0e-02 | ATP1A1,CIITA,CREB1,EGR1,FUT7,INHBA,NOX1,NTS,PDE3B,PTGS2,RHOA,THBS1,UCP3 | NA |
| miR-98 inhibitor | NA | chemical reagent | NA | NA | NA | 2.0e-02 | ADAMTS8,EDN1,FN1 | NA |
| cloprostenol | NA | chemical drug | NA | NA | NA | 2.0e-02 | SOCS1,SOCS3,TIMP1 | NA |
| atelocollagen | NA | chemical reagent | NA | NA | NA | 2.0e-02 | MYOD1,MYOG,PPARG | NA |
| P5091 | NA | chemical reagent | NA | NA | NA | 2.0e-02 | CDH1,MRC1,VIM | NA |
| S-18886 | NA | chemical drug | NA | NA | NA | 2.0e-02 | ALOX12,NCF1,TGFB1 | NA |
| PLD | NA | group | NA | NA | NA | 2.0e-02 | FN1,HIF1A,PTP4A3 | NA |
| PHA-665752 | NA | chemical drug | NA | NA | NA | 2.0e-02 | BCL2L1,PTGS2,TNFRSF10A | NA |
| SF1670 | NA | chemical reagent | NA | NA | NA | 2.0e-02 | CDH1,CDH2,SNAI1 | NA |
| RHBDD1 | 1.30e-01 | peptidase | NA | NA | NA | 2.0e-02 | ACTA2,CDH1,VIM | NA |
| OLFM2 | -8.80e-01 | other | NA | NA | NA | 2.0e-02 | ACTA1,HEY2,TAGLN | NA |
| SOCS7 | 7.40e-01 | other | NA | NA | NA | 2.0e-02 | ELAVL1,IRS1,PPARG | NA |
| HOXA-AS3 | NA | other | NA | NA | NA | 2.0e-02 | CDH1,CDH2,VIM | NA |
| GLIPR2 | -1.22e+00 | other | NA | NA | NA | 2.0e-02 | ACTA2,CDH1,VIM | NA |
| NIPBL | -4.30e-01 | transcription regulator | NA | NA | NA | 2.0e-02 | FOXP3,KLF4,POLE4 | NA |
| HSPBP1 | 4.00e-01 | other | NA | NA | NA | 2.0e-02 | HSPA1A/HSPA1B,HSPA2,SYP | NA |
| NBR2 | NA | other | NA | NA | NA | 2.0e-02 | CDH2,SLC2A1,VIM | NA |
| NLN | -9.00e-02 | peptidase | NA | NA | NA | 2.0e-02 | COX4I1,CREB1,PPARG | NA |
| RNF43 | 1.78e+00 | enzyme | NA | NA | NA | 2.0e-02 | AXIN2,F2RL1,GLUL | NA |
| 5730403I07Rik | NA | other | NA | NA | NA | 2.0e-02 | ARG1,CYBB,PTGS2 | NA |
| KDM7A | 3.90e-01 | enzyme | NA | NA | NA | 2.0e-02 | ICAM1,SELE,VCAM1 | NA |
| AKR1C3 | -5.20e-01 | enzyme | NA | NA | NA | 2.0e-02 | PROS1,SIAH2,TMPRSS2 | NA |
| VLDL | NA | complex | NA | NA | NA | 2.0e-02 | PON2,SERPINE1,VCAM1 | NA |
| firtecan pegol | NA | chemical drug | NA | NA | NA | 2.0e-02 | CA9,CXCR4,SLC2A1 | NA |
| danusertib | NA | chemical drug | NA | NA | NA | 2.0e-02 | BCL2L1,CDKN1A,GADD45A | NA |
| STX12 | -1.80e-01 | other | NA | NA | NA | 2.0e-02 | ABCA1,SELP,VWF | NA |
| TBR1 | NA | transcription regulator | NA | NA | NA | 2.0e-02 | BCL11B,NR4A2,RELN | NA |
| DIO1 | -1.17e+00 | enzyme | NA | NA | NA | 2.0e-02 | SLC16A1,SLC16A3,UCP3 | NA |
| IBSP | 1.00e-01 | other | NA | NA | NA | 2.0e-02 | ITGB3,MMP2,THBS1 | NA |
| PTPRF | -7.80e-01 | phosphatase | NA | NA | NA | 2.0e-02 | CCND1,EMP3,GGT5 | NA |
| GRPR | -2.80e-01 | G-protein coupled receptor | NA | NA | NA | 2.0e-02 | BDNF,CDKN1A,MYCN | NA |
| CACNB4 | -1.23e+00 | ion channel | NA | NA | NA | 2.0e-02 | CACNA1B,CACNB2,CACNB3 | NA |
| Bc1 | NA | translation regulator | NA | NA | NA | 2.0e-02 | ACTA2,CNN1,TAGLN | NA |
| MIR129 | NA | group | NA | NA | NA | 2.0e-02 | CDK6,MAPK3,PRKCE | NA |
| mir-136 | NA | microRNA | NA | NA | NA | 2.0e-02 | CXCL12,IL17A,PDK4 | NA |
| mir-431 | NA | microRNA | NA | NA | NA | 2.0e-02 | CD34,FN1,VCAN | NA |
| PALS1 | NA | kinase | NA | NA | NA | 2.0e-02 | CDH1,MAG,PMP22 | NA |
| ANKH | -7.00e-02 | transporter | NA | NA | NA | 2.0e-02 | COL2A1,SPP1,WNT5A | NA |
| BMS 182874 | NA | chemical reagent | NA | NA | NA | 2.0e-02 | SELE,SELP,VCAM1 | NA |
| TAF12 | 3.30e-01 | transcription regulator | NA | NA | NA | 2.0e-02 | HLA-DRA,IRF1,SELE | NA |
| AHNAK | 2.20e-01 | other | NA | NA | NA | 2.0e-02 | CCND1,CCND2,CDKN1A | NA |
| lanatoside C | NA | chemical - endogenous non-mammalian | NA | NA | NA | 2.0e-02 | CCND2,NUAK1,TNFRSF10A | NA |
| CACNA2D1 | 5.70e-01 | ion channel | NA | NA | NA | 2.0e-02 | CACNA1G,CACNA1I,CD36 | NA |
| KLK6 | NA | peptidase | NA | NA | NA | 2.0e-02 | ADAM10,BCL2L11,CDH1 | NA |
| CTNNAL1 | -9.70e-01 | other | NA | NA | NA | 2.0e-02 | CCND1,FN1,ITGB3 | NA |
| WNT6 | -1.95e+00 | other | NA | NA | NA | 2.0e-02 | MYF5,MYOD1,RUNX2 | NA |
| PTCH2 | NA | transmembrane receptor | NA | NA | NA | 2.0e-02 | CXCL12,JAG1,KITLG | NA |
| BICD2 | 4.30e-01 | other | NA | NA | NA | 2.0e-02 | CXCL10,IFIT1,STAT1 | NA |
| FOXL1 | NA | transcription regulator | NA | NA | NA | 2.0e-02 | PDGFRA,SDC1,WNT5A | NA |
| COL1A2 | NA | other | NA | NA | NA | 2.0e-02 | CDKN1A,SERPINE1,TGFB1 | NA |
| GNPAT | 1.10e-01 | enzyme | NA | NA | NA | 2.0e-02 | Ccl2,UGCG,UGT8 | NA |
| LOC101927189 | NA | other | NA | NA | NA | 2.0e-02 | ARG1,CYBB,PTGS2 | NA |
| LRRC8C | -2.80e-01 | ion channel | NA | NA | NA | 2.0e-02 | LPL,PPARG,SREBF1 | NA |
| ZC3H13 | 6.10e-01 | other | NA | NA | NA | 2.0e-02 | LDHB,PKM,SLC2A1 | NA |
| TXN2 | 5.00e-02 | enzyme | NA | NA | NA | 2.0e-02 | CYBA,CYBB,NCF1 | NA |
| PCCA-DT | NA | other | NA | NA | NA | 2.0e-02 | CDH1,CDH2,VIM | NA |
| PDGFRbeta-recognizing cyclic peptide | NA | chemical reagent | NA | NA | NA | 2.0e-02 | ACTA2,COL1A1,FN1 | NA |
| 1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione | NA | chemical reagent | NA | NA | NA | 2.0e-02 | CEBPD,CREB1,PPARG | NA |
| SB 204741 | NA | chemical reagent | NA | NA | NA | 2.0e-02 | CYP1B1,SEMA6B,TIPARP | NA |
| iopanoic acid | NA | chemical drug | NA | NA | NA | 2.0e-02 | G0S2,G6PD,PNPLA2 | NA |
| stilbene | NA | chemical reagent | NA | NA | NA | 2.0e-02 | CXCL10,IFIT1,ISG15 | NA |
| NSC719239 | NA | chemical drug | NA | NA | NA | 2.0e-02 | ITGA2,ITGA3,ITGA5 | NA |
| cilazapril | NA | chemical drug | NA | NA | NA | 2.0e-02 | ACTA1,COL3A1,MYH7 | NA |
| bumetanide | NA | chemical drug | NA | NA | NA | 2.0e-02 | COL1A1,COL3A1,PTGS2 | NA |
| (-)-isoproterenol | NA | chemical drug | NA | NA | NA | 2.0e-02 | CD44,MMP2,PDE4D | NA |
| nizatidine | NA | chemical drug | NA | NA | NA | 2.0e-02 | CREB1,CREB5,HRH2 | NA |
| nabumetone | NA | chemical drug | NA | NA | NA | 2.0e-02 | ACTC1,MYH6,UTRN | NA |
| ammonia | NA | chemical - endogenous mammalian | NA | NA | NA | 2.0e-02 | AQP4,SLC1A3,SLC7A6 | NA |
| cyclohexanecarboxylic acid | NA | chemical reagent | NA | NA | NA | 2.0e-02 | ENO2,NCAM1,SYP | NA |
| N-butyldeoxynojirimycin | NA | chemical drug | NA | NA | NA | 2.0e-02 | ICAM1,MSR1,PAWR | NA |
| CIL56 | NA | chemical reagent | NA | NA | NA | 2.0e-02 | ALDH1A1,CDK6,PROM1 | NA |
| histidinol | NA | chemical - endogenous mammalian | NA | NA | NA | 2.0e-02 | ASNS,EGR1,GPT2,SLC7A1 | NA |
| IGF2BP2 | -8.00e-02 | translation regulator | NA | NA | NA | 2.0e-02 | Ccl2,LIMS2,SREBF1,TRIM54 | NA |
| TDO2 | -2.00e-01 | enzyme | NA | NA | NA | 2.0e-02 | AHR,PTGS2,SLC1A4,SLC1A5 | NA |
| TBXA2R | -1.80e-01 | G-protein coupled receptor | NA | NA | NA | 2.0e-02 | ICAM1,PTGS2,TGFB1,VCAM1 | NA |
| MLLT3 | NA | transcription regulator | NA | NA | NA | 2.0e-02 | EDN1,HOXD4,SCNN1G,SGK1 | NA |
| FBLN5 | -7.00e-01 | other | NA | NA | NA | 2.0e-02 | CDH1,MMP2,TGFB1,TWIST1 | NA |
| 4-coumaric acid | NA | chemical - endogenous mammalian | NA | NA | NA | 2.0e-02 | CCNA2,CDKN1A,FGF2,PTGS2 | NA |
| anethole | NA | chemical - endogenous non-mammalian | NA | NA | NA | 2.0e-02 | CDH1,IL17A,MMP2,TIMP1 | NA |
| papaverine | NA | chemical drug | NA | NA | NA | 2.0e-02 | BDNF,CAV1,NTRK2,OCLN | NA |
| SMC1B | NA | transporter | NA | NA | NA | 2.0e-02 | DUSP5,DUSP6,ERBB3,MAP3K14,MRNIP,MYADM,OPTN,PEA15,PLK2,TUBB6 | NA |
| ONECUT1 | NA | transcription regulator | NA | NA | NA | 2.0e-02 | ACSS3,ACVR1,ATG101,BCAR1,BCKDHA,C2,CACNA1D,CD36,CDK2,CEBPD,CFI,COPS7A,COX4I1,CXCL13,CYGB,EGR2,ELOA,ELOVL1,EXOSC5,FADS3,FAM117A,HIVEP3,HNRNPR,HSD17B4,HSPA1A/HSPA1B,HTR2B,IRF3,IRF6,KLF3,LAMC2,LPL,MAGED2,MDH1,MON1B,MYOF,NEK6,NFKBIA,NIPAL2,NR0B2,NUAK2,OAZ2,PEX6,PFKFB1,PI4K2B,POLR3G,PPARD,PSMB1,RARG,RECK,SART3,SEC61A2,SERPINB8,SH3BGRL,SLC1A3,SNX3,TMOD2,TRUB2,USP46,VCP,WDR5B,ZBTB45 | NA |
| RYR1 | 7.60e-01 | ion channel | NA | NA | NA | 2.0e-02 | ACAD11,ACADL,ACSL1,CD36,COX4I1,GAPDH,HK1,HSD17B4,MB,PRKAA2,TIMM29,TRPC3,TRPC6 | NA |
| NEO1 | -4.80e-01 | transcription regulator | NA | NA | NA | 2.0e-02 | ADGRG6,CDH1,EXT1,GLI1,MAPK3,PMP22,PTCH1,RGS6 | NA |
| RUVBL2 | 2.40e-01 | transcription regulator | NA | NA | NA | 2.0e-02 | AXIN2,CCND1,CCND2,CDKN2C,RBL1 | NA |
| LIMA1 | -1.10e+00 | other | NA | NA | NA | 2.0e-02 | CDH1,CREB1,ID2,VCAN,VIM | NA |
| NLRP1 | NA | enzyme | NA | NA | NA | 2.0e-02 | CASP1,NLRC4,Nlrp1a,NLRP3,PYCARD | NA |
| Histone h2a | NA | group | NA | NA | NA | 2.0e-02 | EGR1,ESM1,HOXC5,IGFBP5,ITGA6,PTCH1,RUNX2,SMARCD3,TGFB1,ZNF503 | NA |
| Nuclear factor 1 | NA | group | NA | NA | NA | 2.0e-02 | Akr1b7,ALDOA,CHI3L1,CIITA,COL1A1,FAM89B,GFAP,HGF,LOX,TNFSF18 | NA |
| RGS10 | -8.90e-01 | enzyme | NA | NA | NA | 2.0e-02 | ARG1,BCL6,CASP1,Ccl7,CCR1,CCR3,CRP,CX3CL1,CXCL10,IL10RA,IL10RB,IL2RB,ITGB2,SELP,TGFB1,TNFRSF1B | NA |
| SMC1A | -5.00e-02 | transporter | NA | NA | NA | 3.0e-02 | CSF3R,ESRRB,EZH2,ID2,IDH1,IL1RL1,KIT,KLF4,LEF1,POLE4,RUNX1,SOCS1,STAT5B,TINAGL1 | NA |
| ZBTB33 | -8.00e-02 | transcription regulator | NA | NA | NA | 3.0e-02 | BCL6,CDH1,CDKN1A,PGK1,S100A4,TNFRSF10A | NA |
| RFX5 | -2.90e-01 | transcription regulator | NA | NA | NA | 3.0e-02 | B2M,CD74,COL1A1,GCNT2,HLA-DRA,SLC26A3 | NA |
| MBD1 | 2.10e-01 | transcription regulator | NA | NA | NA | 3.0e-02 | BCAT2,CDH1,DPP4,EFNA5,PROM1,SLCO3A1,SNRPN,WDR46 | NA |
| 8-bromo-cyclic ADP-ribose | NA | chemical reagent | NA | NA | NA | 3.0e-02 | COL1A1,TGFB1 | NA |
| ritanserin | NA | chemical drug | NA | NA | NA | 3.0e-02 | BDNF,PRKD1 | NA |
| arbutin | NA | chemical drug | NA | NA | NA | 3.0e-02 | CDKN1A,PTGS2 | NA |
| gentamicin C1 | NA | chemical drug | NA | NA | NA | 3.0e-02 | CD44,SPP1 | NA |
| 7beta-hydroxycholesterol | NA | chemical - endogenous mammalian | NA | NA | NA | 3.0e-02 | NR4A1,NR4A2 | NA |
| MS049 | NA | chemical reagent | NA | NA | NA | 3.0e-02 | CDH1,VIM | NA |
| Steroid 5 alpha-Reductase | NA | group | NA | NA | NA | 3.0e-02 | CDH1,PTGS2 | NA |
| staphylococcus aureus peptidoglycan G | NA | chemical reagent | NA | NA | NA | 3.0e-02 | SELE,VCAM1 | NA |
| B7-33 | NA | chemical reagent | NA | NA | NA | 3.0e-02 | MMP2,TIMP1 | NA |
| KJ-Pyr-9 | NA | chemical reagent | NA | NA | NA | 3.0e-02 | ACTA2,COL1A1 | NA |
| AKIRIN1 | 6.00e-01 | enzyme | NA | NA | NA | 3.0e-02 | MYOD1,MYOG | NA |
| ARHGEF12 | 1.60e-01 | other | NA | NA | NA | 3.0e-02 | ACTA2,RHOA | NA |
| DIXDC1 | -2.16e+00 | other | NA | NA | NA | 3.0e-02 | KDR,SNAI1 | NA |
| DTX1-EP300-NICD | NA | complex | NA | NA | NA | 3.0e-02 | CNP,MAG | NA |
| Pdgfra-Pdgfrb | NA | complex | NA | NA | NA | 3.0e-02 | CSF1,TIMP1 | NA |
| glemanserin | NA | chemical drug | NA | NA | NA | 3.0e-02 | NR4A1,NR4A3 | NA |
| dacetuzumab | NA | biologic drug | NA | NA | NA | 3.0e-02 | BCL2L1,TP63 | NA |
| Rbp | NA | group | NA | NA | NA | 3.0e-02 | PPARG,SOCS3 | NA |
| polytef | NA | chemical drug | NA | NA | NA | 3.0e-02 | F3,SELE | NA |
| sPla2 | NA | group | NA | NA | NA | 3.0e-02 | PTGES,PTGS2 | NA |
| MBNL3 | -3.00e-02 | other | NA | NA | NA | 3.0e-02 | ABLIM1,CD44 | NA |
| Rab11 | NA | group | NA | NA | NA | 3.0e-02 | ITGA6,TRPC6 | NA |
| FAM120B | -5.90e-01 | other | NA | NA | NA | 3.0e-02 | ADIPOQ,PLIN1 | NA |
| ZIC5 | NA | transcription regulator | NA | NA | NA | 3.0e-02 | CDH1,PDGFD | NA |
| FBXO3 | -1.50e-01 | enzyme | NA | NA | NA | 3.0e-02 | FBXL2,NLRP3 | NA |
| PDZD11 | -8.20e-01 | other | NA | NA | NA | 3.0e-02 | NECTIN1,NECTIN3 | NA |
| API5 | -5.00e-01 | other | NA | NA | NA | 3.0e-02 | CDK2,FGF2 | NA |
| ZNF367 | -6.60e-01 | transcription regulator | NA | NA | NA | 3.0e-02 | CIT,TP53BP2 | NA |
| CENPL | 1.00e-02 | other | NA | NA | NA | 3.0e-02 | CCNE2,CDK2 | NA |
| HNRNPLL | -1.60e-01 | other | NA | NA | NA | 3.0e-02 | ECM1,PTPRC | NA |
| GPR4 | -3.60e-01 | G-protein coupled receptor | NA | NA | NA | 3.0e-02 | ICAM1,VCAM1 | NA |
| CYTL1 | 1.60e-01 | cytokine | NA | NA | NA | 3.0e-02 | IGF1,NDUFV1 | NA |
| VPS33B | 2.70e-01 | transporter | NA | NA | NA | 3.0e-02 | SELP,VWF | NA |
| PPM1E | -2.60e-01 | phosphatase | NA | NA | NA | 3.0e-02 | CDH2,VIM | NA |
| KLK10 | NA | peptidase | NA | NA | NA | 3.0e-02 | ICAM1,VCAM1 | NA |
| PLEKHA7 | NA | other | NA | NA | NA | 3.0e-02 | NECTIN1,NECTIN3 | NA |
| RFX7 | 3.00e-01 | transcription regulator | NA | NA | NA | 3.0e-02 | DDIT4,FOXP3 | NA |
| CPEB2 | 3.50e-01 | translation regulator | NA | NA | NA | 3.0e-02 | HIF1A,TWIST1 | NA |
| AGO3 | 3.00e-01 | translation regulator | NA | NA | NA | 3.0e-02 | BCL2L11,CXCR4 | NA |
| ACER3 | -1.56e+00 | enzyme | NA | NA | NA | 3.0e-02 | ACER2,CDKN1A | NA |
| CBP-ICSBP-IRF-1-PU.1 | NA | complex | NA | NA | NA | 3.0e-02 | CYBB,NCF2 | NA |
| PTPase | NA | group | NA | NA | NA | 3.0e-02 | ABCA1,IRS1 | NA |
| RYR3 | -4.50e-01 | ion channel | NA | NA | NA | 3.0e-02 | ADIPOQ,ATF3 | NA |
| ginkgetin | NA | chemical - endogenous non-mammalian | NA | NA | NA | 3.0e-02 | BCL2L1,CASP3 | NA |
| CTS-1027 | NA | chemical drug | NA | NA | NA | 3.0e-02 | ACTA2,COL1A1 | NA |
| MCF2L | -1.00e-02 | other | NA | NA | NA | 3.0e-02 | CCND1,RHOA | NA |
| FAIM2 | -1.20e-01 | other | NA | NA | NA | 3.0e-02 | CASP3,CASP8 | NA |
| PTPRG | 1.40e-01 | phosphatase | NA | NA | NA | 3.0e-02 | CD34,KIT | NA |
| SCN1A | -1.97e+00 | ion channel | NA | NA | NA | 3.0e-02 | GFAP,VIM | NA |
| CELA1 | 6.30e-01 | peptidase | NA | NA | NA | 3.0e-02 | HLA-A,HSPA1A/HSPA1B | NA |
| RAC3 | -2.60e-01 | enzyme | NA | NA | NA | 3.0e-02 | CCND1,SNAI1 | NA |
| MLIP | 3.30e-01 | transcription regulator | NA | NA | NA | 3.0e-02 | HK1,SLC2A1 | NA |
| PLA2G2F | -9.00e-02 | enzyme | NA | NA | NA | 3.0e-02 | PTGES,PTGS2 | NA |
| IGFALS | 1.57e+00 | other | NA | NA | NA | 3.0e-02 | IGF1,PPARG | NA |
| mir-202 | NA | microRNA | NA | NA | NA | 3.0e-02 | ESPL1,REC8 | NA |
| mir-944 | NA | microRNA | NA | NA | NA | 3.0e-02 | CDH2,VIM | NA |
| IKKbeta inhibitor | NA | chemical drug | NA | NA | NA | 3.0e-02 | CDH1,CDH2 | NA |
| Id | NA | group | NA | NA | NA | 3.0e-02 | ACTC1,CKM | NA |
| MIR5590 | NA | microRNA | NA | NA | NA | 3.0e-02 | CDH1,VIM | NA |
| EYA2 | 1.63e+00 | phosphatase | NA | NA | NA | 3.0e-02 | MYOG,SOCS3 | NA |
| POLDIP3 | -3.40e-01 | other | NA | NA | NA | 3.0e-02 | CDKN1A,ISG15 | NA |
| VPS35 | -4.40e-01 | transporter | NA | NA | NA | 3.0e-02 | PPARG,SLC38A2 | NA |
| FBXW8 | 4.20e-01 | enzyme | NA | NA | NA | 3.0e-02 | IRS1,MAP4K1 | NA |
| BCAN | -1.71e+00 | other | NA | NA | NA | 3.0e-02 | CDH2,ITGB3 | NA |
| DPYSL3 | -1.03e+00 | enzyme | NA | NA | NA | 3.0e-02 | SNAI1,TWIST1 | NA |
| ME1 | 1.20e-01 | enzyme | NA | NA | NA | 3.0e-02 | IRS1,IRS2 | NA |
| PLEKHA1 | -4.30e-01 | other | NA | NA | NA | 3.0e-02 | CD86,SLC2A1 | NA |
| ING2 | 4.30e-01 | transcription regulator | NA | NA | NA | 3.0e-02 | SERPINE1,SPP1 | NA |
| MYLK | -4.20e-01 | kinase | NA | NA | NA | 3.0e-02 | CASP3,CASP8 | NA |
| AGO4 | NA | translation regulator | NA | NA | NA | 3.0e-02 | BCL2L11,CXCR4 | NA |
| RFNG | 9.20e-01 | enzyme | NA | NA | NA | 3.0e-02 | DTX1,IL2RA | NA |
| NPAS3 | NA | transcription regulator | NA | NA | NA | 3.0e-02 | FGFR1,RELN | NA |
| LRP1B | NA | transmembrane receptor | NA | NA | NA | 3.0e-02 | ABCA1,NCEH1 | NA |
| ING5 | NA | other | NA | NA | NA | 3.0e-02 | CDK2,CDKN1A | NA |
| PLEKHA2 | 5.10e-01 | other | NA | NA | NA | 3.0e-02 | CD86,SLC2A1 | NA |
| CBR1 | NA | enzyme | NA | NA | NA | 3.0e-02 | CDH1,PTGS2 | NA |
| KHDRBS2 | NA | other | NA | NA | NA | 3.0e-02 | CDKN1A,STAT1 | NA |
| ADAMTS5 | -6.90e-01 | peptidase | NA | NA | NA | 3.0e-02 | BGN,VCAN | NA |
| 17beta-estradiol dendrimer conjugate | NA | chemical reagent | NA | NA | NA | 3.0e-02 | CALCR,CTSK | NA |
| CDO1 | -1.02e+00 | enzyme | NA | NA | NA | 3.0e-02 | IGF1,MYOD1 | NA |
| 14,15-epoxyeicosa-5(Z)-enoic acid | NA | chemical reagent | NA | NA | NA | 3.0e-02 | Ccl2,SELE | NA |
| EVC | -9.30e-01 | other | NA | NA | NA | 3.0e-02 | GLI1,PTCH1 | NA |
| CRTAP | NA | other | NA | NA | NA | 3.0e-02 | CDKN1A,SERPINE1 | NA |
| Sf1 | 3.10e-01 | other | NA | NA | NA | 3.0e-02 | Ccl2,VCAM1 | NA |
| CCL3L1 | NA | other | NA | NA | NA | 3.0e-02 | ACKR2,CCR5 | NA |
| INTU | NA | other | NA | NA | NA | 3.0e-02 | GLI1,PTCH1 | NA |
| CLEC2D | NA | transmembrane receptor | NA | NA | NA | 3.0e-02 | CD83,CXCR4 | NA |
| RPS4Y1 | -2.90e-01 | other | NA | NA | NA | 3.0e-02 | CDH2,VIM | NA |
| PEX14 | 4.10e-01 | transcription regulator | NA | NA | NA | 3.0e-02 | BDNF,PTGS2 | NA |
| ZFYVE16 | -6.90e-01 | other | NA | NA | NA | 3.0e-02 | CDKN1A,SERPINE1 | NA |
| 1,5-bis-(dihexyl-N-nitrosoamino)-2,4-dinitrobenzene | NA | chemical reagent | NA | NA | NA | 3.0e-02 | CYBB,PDE5A | NA |
| ERH | 5.80e-01 | other | NA | NA | NA | 3.0e-02 | SOCS3,WNT5A | NA |
| fidarestat | NA | chemical drug | NA | NA | NA | 3.0e-02 | NLRP3,PYCARD | NA |
| indotecan | NA | chemical drug | NA | NA | NA | 3.0e-02 | HIF1A,SLC2A1 | NA |
| IPP-204106N | NA | chemical drug | NA | NA | NA | 3.0e-02 | ANGPT2,CA9 | NA |
| E-c-HDMAPP | NA | chemical reagent | NA | NA | NA | 3.0e-02 | BCL2A1,CCND2 | NA |
| RK-24466 | NA | chemical drug | NA | NA | NA | 3.0e-02 | PLCG2,RUNX1 | NA |
| XMD 8-92 | NA | chemical drug | NA | NA | NA | 3.0e-02 | SELE,SNAI2 | NA |
| TP-10 | NA | chemical reagent | NA | NA | NA | 3.0e-02 | Ccl2,HIF1A | NA |
| crenigacestat | NA | chemical drug | NA | NA | NA | 3.0e-02 | PROM1,VIM | NA |
| HO-3867 | NA | chemical reagent | NA | NA | NA | 3.0e-02 | BCL2L1,TGFA | NA |
| hydroxyl radical | NA | chemical toxicant | NA | NA | NA | 3.0e-02 | CAV1,KLF4 | NA |
| ZM 306416 | NA | chemical drug | NA | NA | NA | 3.0e-02 | ANGPT2,KDR | NA |
| minalrestat | NA | chemical drug | NA | NA | NA | 3.0e-02 | FGF2,PRKCE | NA |
| pyridoxal | NA | chemical - endogenous mammalian | NA | NA | NA | 3.0e-02 | MAPK3,PTGS2 | NA |
| sarpogrelate | NA | chemical drug | NA | NA | NA | 3.0e-02 | F3,SERPINE1 | NA |
| methiothepin | NA | chemical drug | NA | NA | NA | 3.0e-02 | F3,SERPINE1 | NA |
| amlexanox | NA | chemical drug | NA | NA | NA | 3.0e-02 | CCND1,HIF1A | NA |
| milrinone | NA | chemical drug | NA | NA | NA | 3.0e-02 | CREM,F3 | NA |
| PSB-1115 | NA | chemical reagent | NA | NA | NA | 3.0e-02 | HIF1A,PDE5A | NA |
| SB 559457 | NA | chemical reagent | NA | NA | NA | 3.0e-02 | DDIT4,GAPDH | NA |
| dioctyl adipate | NA | chemical toxicant | NA | NA | NA | 3.0e-02 | CD36,SLC27A1 | NA |
| CGP77675 | NA | chemical drug | NA | NA | NA | 3.0e-02 | FN1,PTGS2 | NA |
| KR 62436 | NA | chemical reagent | NA | NA | NA | 3.0e-02 | CXCL12,CXCR4 | NA |
| NSC 651016 | NA | chemical reagent | NA | NA | NA | 3.0e-02 | CCR5,CXCR4 | NA |
| AGI-1095 | NA | chemical reagent | NA | NA | NA | 3.0e-02 | EGR1,F3 | NA |
| barium chloride | NA | chemical toxicant | NA | NA | NA | 3.0e-02 | LOX,LOXL1 | NA |
| HEY1-NCOA2 | NA | fusion gene/product | NA | NA | NA | 3.0e-02 | PDGFB,PDGFRA | NA |
| GSK2656157 | NA | chemical drug | NA | NA | NA | 3.0e-02 | BDNF,ERBB3 | NA |
| AJH-836 | NA | chemical reagent | NA | NA | NA | 3.0e-02 | PRKCD,PRKCE | NA |
| 1,1-bis(3’-indolyl)-1-(4-chlorophenyl)methane | NA | chemical reagent | NA | NA | NA | 3.0e-02 | CASP3,NR4A2 | NA |
| 3-hydroxyflavone | NA | chemical - endogenous non-mammalian | NA | NA | NA | 3.0e-02 | BCL2L1,HSPA1A/HSPA1B | NA |
| 3-keto, N-aminoethyl aminocaproyl dihydrocinnamoyl cyclopamine | NA | chemical reagent | NA | NA | NA | 3.0e-02 | MYOD1,SFRP1 | NA |
| lysophospholipids | NA | chemical - endogenous mammalian | NA | NA | NA | 3.0e-02 | CLDN1,OCLN | NA |
| oleylamide | NA | chemical - endogenous mammalian | NA | NA | NA | 3.0e-02 | LPL,PPARG | NA |
| epoxyeicosatrienoic acid | NA | chemical - other | NA | NA | NA | 3.0e-02 | ALOX5,PTGS2 | NA |
| tibolone | NA | chemical drug | NA | NA | NA | 3.0e-02 | PFKFB3,SERPINE1 | NA |
| arylsulfonamide 64B | NA | chemical reagent | NA | NA | NA | 3.0e-02 | CXCR4,MET | NA |
| TFEC | 1.10e-01 | transcription regulator | NA | NA | NA | 3.0e-02 | ATP2A1,BCL11A,COL6A3,CSF3R,F13A1,GBP7,PSMA6 | NA |
| PRKCG | 1.40e-01 | kinase | NA | NA | NA | 3.0e-02 | ADORA2A,CCND1,COX4I1,COX6B1,MAP1B,MAP2,MYH7,NDUFA1,NDUFA7,NDUFB3,NDUFB9,NDUFS7,OXTR,PVALB,UQCR10,UQCR11 | NA |
| SLC2A10 | -1.22e+00 | transporter | NA | NA | NA | 3.0e-02 | ADIPOQ,DLK1,PPARG,PPARGC1B | NA |
| SPIC | -4.40e-01 | transcription regulator | NA | NA | NA | 3.0e-02 | CCL24,FCGR2B,IL2RA,KIT | NA |
| immune complex | NA | complex | NA | NA | NA | 3.0e-02 | IL1RN,SOCS1,SOCS3,VCAM1 | NA |
| BANP | 1.80e-01 | other | NA | NA | NA | 3.0e-02 | CCND1,CDH1,CDKN1A,SNAI2 | NA |
| DLC1 | -1.06e+00 | other | NA | NA | NA | 3.0e-02 | CDH1,CDK6,S100A10,SERPINE1 | NA |
| SMN1/SMN2 | 3.80e-01 | other | NA | NA | NA | 3.0e-02 | Ccl2,Ccl7,IGF1,UTRN | NA |
| GRIP1 | 4.80e-01 | transcription regulator | NA | NA | NA | 3.0e-02 | FREM2,GRIA2,IGF1,PTGS2 | NA |
| CSNK2A2 | -4.00e-02 | kinase | NA | NA | NA | 3.0e-02 | CDH1,FOXO3,ITGA6,SNAI1 | NA |
| BLM | 1.80e-01 | enzyme | NA | NA | NA | 3.0e-02 | CDKN1A,IFI44L,IFIT1,MX1 | NA |
| dexamethasone/INS/isobutylmethylxanthine | NA | chemical reagent | NA | NA | NA | 3.0e-02 | ADIPOQ,CCNA2,LPL,PPARG | NA |
| IRF2BP1 | 6.40e-01 | transcription regulator | NA | NA | NA | 3.0e-02 | ADAMTS1,AIDA,ATF3,DUSP1,EGR2,EMP1,HOXD10,INHBA,OSR2,PFKFB4,SEC24D,TNFRSF11B | NA |
| TBP | -5.50e-01 | transcription regulator | NA | NA | NA | 3.0e-02 | ASNS,BCL2A1,CDKN1A,COL1A1,FN1,FOXP3,GAPDH,GATA4,HLA-A,IER3,MEOX2,NFKBIA,NKD1,PPARG,PPP2R2B,PTGS2,RANBP1,RPS10,TGFA | NA |
| IFNLR1 | -1.09e+00 | transmembrane receptor | NA | NA | NA | 3.0e-02 | ATF3,CSF1,CXCL10,IFI44,IFIH1,ISG15,MX1,OASL,PTGS2,RSAD2,THBS1,TLR2,TNFAIP2 | NA |
| MOS | NA | kinase | NA | NA | NA | 4.0e-02 | MRPL21,MRPL22,MRPS12,MRPS9,NDUFA1,NDUFC1,RPL22,RPL6 | NA |
| divalinal-angiotensin IV | NA | chemical reagent | NA | NA | NA | 4.0e-02 | Ccl2,ICAM1,MMP2 | NA |
| L-aspartic acid | NA | chemical - endogenous mammalian | NA | NA | NA | 4.0e-02 | CCND1,CDKN1A,PRKAA2 | NA |
| p38 Sapk | NA | group | NA | NA | NA | 4.0e-02 | CCND1,CD83,CD86 | NA |
| globotriaosylceramide | NA | chemical - endogenous mammalian | NA | NA | NA | 4.0e-02 | CD44,FGF2,LAMP2 | NA |
| CF-02 | NA | chemical reagent | NA | NA | NA | 4.0e-02 | CASP1,NLRP3,PYCARD | NA |
| ranolazine | NA | chemical drug | NA | NA | NA | 4.0e-02 | ICAM1,SELE,VCAM1 | NA |
| Hbb | NA | other | NA | NA | NA | 4.0e-02 | GDF11,ICAM1,VCAM1 | NA |
| Erm | NA | group | NA | NA | NA | 4.0e-02 | CAV1,CD44,ICAM1 | NA |
| beta-sitosterol | NA | chemical reagent | NA | NA | NA | 4.0e-02 | PTGS2,SELE,VCAM1 | NA |
| FICD | 3.10e-01 | enzyme | NA | NA | NA | 4.0e-02 | DNAJB1,HSP90AA1,HSPA1A/HSPA1B | NA |
| GGCT | 6.40e-01 | enzyme | NA | NA | NA | 4.0e-02 | CDH1,CDH2,MMP2 | NA |
| MLYCD | 1.30e-01 | enzyme | NA | NA | NA | 4.0e-02 | CD36,PDK4,UCP3 | NA |
| GSDMB | NA | other | NA | NA | NA | 4.0e-02 | ALOX5,ENO2,TGFB1 | NA |
| PYCR1 | 1.00e-01 | enzyme | NA | NA | NA | 4.0e-02 | CDH1,CDH2,VIM | NA |
| ZMIZ2 | 9.00e-02 | transcription regulator | NA | NA | NA | 4.0e-02 | AXIN2,CCND1,CD44 | NA |
| DRD1/5 | NA | group | NA | NA | NA | 4.0e-02 | BDNF,GNAL,NAT8L | NA |
| Gata | NA | group | NA | NA | NA | 4.0e-02 | EDN1,ITGA2B,KDR | NA |
| sGC | NA | complex | NA | NA | NA | 4.0e-02 | BDNF,EGR1,FOXP3 | NA |
| Laminin2 | NA | complex | NA | NA | NA | 4.0e-02 | ACTA2,DMP1,RHOA | NA |
| betulin | NA | chemical - endogenous non-mammalian | NA | NA | NA | 4.0e-02 | BCL2L1,PTGS2,TIMP1 | NA |
| PU-H71 | NA | chemical drug | NA | NA | NA | 4.0e-02 | BTK,LYN,SYK | NA |
| VTRNA2-1 | NA | other | NA | NA | NA | 4.0e-02 | CDH1,CLDN1,OCLN | NA |
| carvacrol | NA | chemical drug | NA | NA | NA | 4.0e-02 | AQP4,CASP3,PTGS2 | NA |
| Mucin | NA | group | NA | NA | NA | 4.0e-02 | CD83,CD86,PTGS2 | NA |
| EIF3I | 3.30e-01 | translation regulator | NA | NA | NA | 4.0e-02 | CCND1,PTGS2,SERPINE1 | NA |
| ACSL6 | 3.30e-01 | enzyme | NA | NA | NA | 4.0e-02 | CASP1,CASP3,COL2A1 | NA |
| IL31RA | -5.10e-01 | transmembrane receptor | NA | NA | NA | 4.0e-02 | CISH,SOCS1,SOCS3 | NA |
| CHKA | 6.10e-01 | kinase | NA | NA | NA | 4.0e-02 | CHKA,PTGS2,TGFB1 | NA |
| LRP8 | -7.00e-01 | transmembrane receptor | NA | NA | NA | 4.0e-02 | ABCA1,DAB1,RELN | NA |
| CD93 | -1.40e+00 | other | NA | NA | NA | 4.0e-02 | CCL21,CYP27A1,ZNF503 | NA |
| MCF2 | NA | other | NA | NA | NA | 4.0e-02 | CCND1,ITGA1,ITGA2 | NA |
| EAF2 | NA | transcription regulator | NA | NA | NA | 4.0e-02 | HIF1A,THBS1,WNT4 | NA |
| mir-612 | NA | microRNA | NA | NA | NA | 4.0e-02 | CDH1,CDH2,VIM | NA |
| RBM14 | -5.60e-01 | transcription regulator | NA | NA | NA | 4.0e-02 | CCND1,SKP2,SOX6 | NA |
| SEPTIN9 | NA | enzyme | NA | NA | NA | 4.0e-02 | ARHGAP4,CCND1,HIF1A | NA |
| CFHR3 | NA | other | NA | NA | NA | 4.0e-02 | C3,C3AR1,CFB | NA |
| CANX | -3.80e-01 | other | NA | NA | NA | 4.0e-02 | ABCA1,NOX4,SLC6A5 | NA |
| NME3 | -2.40e-01 | kinase | NA | NA | NA | 4.0e-02 | ITGA1,ITGA2,VIM | NA |
| PRMT2 | -4.40e-01 | enzyme | NA | NA | NA | 4.0e-02 | CCND1,CDH1,SNAI1 | NA |
| RBM3 | 4.70e-01 | other | NA | NA | NA | 4.0e-02 | ACTA2,CD44,TAGLN | NA |
| SH3GL1 | 4.50e-01 | other | NA | NA | NA | 4.0e-02 | COL3A1,FN1,MMP14 | NA |
| LDN-193189 | NA | chemical drug | NA | NA | NA | 4.0e-02 | SELE,VCAM1,VIM | NA |
| CMA1 | -1.82e+00 | peptidase | NA | NA | NA | 4.0e-02 | COL1A1,COL3A1,CPA3 | NA |
| ARHGEF2 | -6.50e-01 | other | NA | NA | NA | 4.0e-02 | CCND1,EDN1,VCAM1 | NA |
| VCAM1 | -9.60e-01 | transmembrane receptor | NA | NA | NA | 4.0e-02 | CCND1,CD44,VCAM1 | NA |
| CDC27 | -2.20e-01 | other | NA | NA | NA | 4.0e-02 | CCND1,PLK1,SKP2 | NA |
| SSBP1 | 7.70e-01 | other | NA | NA | NA | 4.0e-02 | HLA-DRA,TGFB1,TSHR | NA |
| Wfdc17 | NA | other | NA | NA | NA | 4.0e-02 | ARG1,Ccl2,MRC1 | NA |
| Foxp2 | NA | transcription regulator | NA | NA | NA | 4.0e-02 | HOPX,MYCN,PDPN | NA |
| RFXANK | 2.70e-01 | transcription regulator | NA | NA | NA | 4.0e-02 | EPHA3,HLA-A,HLA-DRA | NA |
| RAB4A | 4.20e-01 | enzyme | NA | NA | NA | 4.0e-02 | KCNH2,MYH7,NEDD4L | NA |
| CLDN2 | -2.80e-01 | other | NA | NA | NA | 4.0e-02 | CCND1,ITGA2,ITGA5 | NA |
| PMX 205 | NA | chemical reagent | NA | NA | NA | 4.0e-02 | BMP1,BMP4,THBS1 | NA |
| ATP5PO | NA | transporter | NA | NA | NA | 4.0e-02 | CASP3,CDH1,CDH2 | NA |
| gabapentin | NA | chemical drug | NA | NA | NA | 4.0e-02 | GFAP,NCAM1,NOS1 | NA |
| 2-cyclohexen-1-one | NA | chemical - endogenous non-mammalian | NA | NA | NA | 4.0e-02 | ICAM1,PTGS2,VCAM1 | NA |
| methylamine | NA | chemical - endogenous mammalian | NA | NA | NA | 4.0e-02 | FN1,MET,SLC2A1 | NA |
| N-hydroxy-N’-(4-butyl-2-methylphenyl)formamidine | NA | chemical reagent | NA | NA | NA | 4.0e-02 | CYBB,FN1,NCF1 | NA |
| benidipine | NA | chemical drug | NA | NA | NA | 4.0e-02 | CDKN1A,SELE,SELP | NA |
| cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate | NA | chemical reagent | NA | NA | NA | 4.0e-02 | Ccl2,MRC1,STAT6 | NA |
| pegintron | NA | biologic drug | NA | NA | NA | 4.0e-02 | CXCL10,ISG15,USP18 | NA |
| Collagen type V | NA | complex | NA | NA | NA | 4.0e-02 | ITGA2,ITGA5,ITGB3 | NA |
| MIR143-145a | NA | group | NA | NA | NA | 4.0e-02 | ACTA2,CNN1,TAGLN | NA |
| CBFB-MYH11 | NA | fusion gene/product | NA | NA | NA | 4.0e-02 | ATF3,SPARC,SPHK1 | NA |
| DIM-C-pPhCO2Me | NA | chemical reagent | NA | NA | NA | 4.0e-02 | CDH2,SNAI1,SNAI2 | NA |
| angustibalin | NA | chemical - endogenous non-mammalian | NA | NA | NA | 4.0e-02 | ACTA2,COL1A1,FN1 | NA |
| DASA-58 | NA | chemical reagent | NA | NA | NA | 4.0e-02 | ABCA1,ABCG1,CD36 | NA |
| cannabinoid | NA | chemical drug | NA | NA | NA | 4.0e-02 | CNR1,CXCR4,ICAM1 | NA |
| allosamidin | NA | chemical reagent | NA | NA | NA | 4.0e-02 | ABCA1,ABCG1,CD36 | NA |
| CCL1 | NA | cytokine | NA | NA | NA | 4.0e-02 | IL17A,ITGA2,ITGB2,MMP2,SERPINE1 | NA |
| CAV3 | 4.10e-01 | enzyme | NA | NA | NA | 4.0e-02 | CAV2,CDKN1A,MYOD1,MYOG,PPARG | NA |
| DRD1 | 1.80e-01 | G-protein coupled receptor | NA | NA | NA | 4.0e-02 | BDNF,EGR1,HOMER1,HTR1B,S100A10 | NA |
| MED30 | -4.40e-01 | transcription regulator | NA | NA | NA | 4.0e-02 | COX6A2,Esrra,FOXP3,LPL,NDUFB3,NDUFS7,NDUFV1 | NA |
| HISTONE | NA | group | NA | NA | NA | 4.0e-02 | AHR,ARG1,CDK6,CIITA,DKK3,FGF2,NOD2,PTGIS,SELP,SFRP5 | NA |
| CNOT7 | -1.20e-01 | transcription regulator | NA | NA | NA | 4.0e-02 | B2M,CLDN1,HERC6,IFI44L,ISG15,OAS3,PPM1K,SP110,STAT1,UBE2L6 | NA |
| RCOR1 | -3.40e-01 | transcription regulator | NA | NA | NA | 4.0e-02 | COL1A1,GAD1,PTGS2,SCN1A,SERPINE1,SMAD7 | NA |
| FGD3 | -7.60e-01 | other | NA | NA | NA | 5.0e-02 | CSNK2B,MAP3K14,NFKBIA,PRKCQ,TICAM2,TLR4,TRADD | NA |
| atrazine | NA | chemical toxicant | NA | NA | NA | 5.0e-02 | CLEC11A,GATA4,PTGS2,STAR | NA |
| TACSTD2 | NA | other | NA | NA | NA | 5.0e-02 | CCND1,CREB1,NCAM1,SYP | NA |
| MKX | 4.00e-02 | transcription regulator | NA | NA | NA | 5.0e-02 | COL1A1,COL3A1,SOX6,TNMD | NA |
| TIP60 | NA | complex | NA | NA | NA | 5.0e-02 | CDKN1A,COL2A1,MYCN,RBL1 | NA |
| ACACA | 4.00e-02 | enzyme | NA | NA | NA | 5.0e-02 | FIS1,GPAM,PPARG,SREBF1 | NA |
| SFRP2 | -1.66e+00 | transmembrane receptor | NA | NA | NA | 5.0e-02 | KLF4,MMP2,PDGFRA,SNAI2 | NA |
| SEMA3A | -1.02e+00 | other | NA | NA | NA | 5.0e-02 | CDH1,KDR,MAP1B,RHOA | NA |
| NELFA | 4.00e-02 | other | NA | NA | NA | 5.0e-02 | CCNE2,CDKN1A,CYP1B1,TOP2A | NA |
| MPL | 6.50e-01 | transmembrane receptor | NA | NA | NA | 5.0e-02 | ITGA2B,ITGB3,SELP,SLC2A1 | NA |
| ANPEP | -1.21e+00 | peptidase | NA | NA | NA | 5.0e-02 | ANPEP,DPP4,IL1RN,TGFB1 | NA |
| CCL7 | NA | cytokine | NA | NA | NA | 5.0e-02 | F3,ICAM1,SOX18,VCAM1 | NA |
| RP 73401 | NA | chemical toxicant | NA | NA | NA | 5.0e-02 | BTG2,EGR1,RARA,STAT1 | NA |
Muscle %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S13. Ingenuity upstream regulators predicted to have similar activatory or inhibitory effect to ozone in Muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))## Warning in instance$preRenderHook(instance): It seems your data is too big for
## client-side DataTables. You may consider server-side processing:
## https://rstudio.github.io/DT/server.htmlrm(list = setdiff(ls(), lsf.str()))
load(file="../output_files/contrasts/DEG_only.R")
toupper(DEG$gene) -> DEG$gene
twj_HeatmapToTable(data = DEG, pathway = "Hypoxia", db = "Msig") -> Hypoxia
twj_HeatmapToTable(data = DEG, pathway = "Polyamine metabolism", db = "Reactome",event.id = "R-HSA-351202") -> Polyamine
twj_HeatmapToTable(data = DEG, pathway = "Amino acid metabolism", db = "Reactome",event.id = "R-HSA-71291") -> AAMet
twj_HeatmapToTable(data = DEG, pathway = "GPCR Signaling", db = "Reactome",event.id = "R-HSA-372790") -> GPCR
twj_HeatmapToTable(data = DEG, pathway = "Adrenoreceptors", db = "Reactome",event.id = "R-HSA-390696") -> Adreno
twj_HeatmapToTable(data= DEG, pathway = "GR",db = "Msig") -> GR_signaling
twj_HeatmapToTable(data = DEG, pathway = "Androgen Response", db = "Msig") -> AR
twj_HeatmapToTable(data = DEG, pathway = "FGFR", db = "Reactome",event.id = "R-HSA-190236") -> FGFR
twj_HeatmapToTable(data = DEG, pathway = "Early Estrogen Response", db = "Msig") -> EarlyEstrogen
twj_HeatmapToTable(data = DEG, pathway = "TNFa via NFkB", db = "Msig") -> TNFa
twj_HeatmapToTable(data = DEG, pathway = "Carbohydrate metabolism", db = "Reactome",event.id = "R-HSA-71387") -> CarbMet
twj_HeatmapToTable(data = DEG, pathway = "Lipid metabolism", db = "Reactome",event.id = "R-HSA-556833") -> LipidMet
twj_HeatmapToTable(data = DEG, pathway = "Local_acute_inflammatory", db = "Msig") -> AcuteInflamm
twj_HeatmapToTable(data = DEG, pathway = "Chemokine", db = "Reactome",event.id = "R-HSA-190236") -> Chemokine
twj_HeatmapToTable(data = DEG, pathway = "Immunoregulatory interactions", db = "Reactome",event.id = "R-HSA-198933") -> ImmunoregulatoryHypoxia %>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>%
kable(caption = "Supplementary Table 14. Relative changes in the expression of genes involved in hypoxia response after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(Hypoxia$Adrenal_padj),F,ifelse(Hypoxia$Adrenal_padj<.1,T,F)),color= ifelse(is.na(Hypoxia$Adrenal_padj),"gray",ifelse(Hypoxia$Adrenal_padj<.1,spec_color(Hypoxia$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(Hypoxia$HT_padj),F,ifelse(Hypoxia$HT_padj<.1,T,F)),color= ifelse(is.na(Hypoxia$HT_padj),"gray",ifelse(Hypoxia$HT_padj<.1,spec_color(Hypoxia$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(Hypoxia$Liver_padj),F,ifelse(Hypoxia$Liver_padj<.1,T,F)),color= ifelse(is.na(Hypoxia$Liver_padj),"gray",ifelse(Hypoxia$Liver_padj<.1,spec_color(Hypoxia$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(Hypoxia$Lung_padj),F,ifelse(Hypoxia$Lung_padj<.1,T,F)),color= ifelse(is.na(Hypoxia$Lung_padj),"gray",ifelse(Hypoxia$Lung_padj <.1,spec_color(Hypoxia$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(Hypoxia$Adipose_padj),F,ifelse(Hypoxia$Adipose_padj<.1,T,F)),color= ifelse(is.na(Hypoxia$Adipose_padj),"gray",ifelse(Hypoxia$Adipose_padj<.1, spec_color(Hypoxia$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(Hypoxia$Muscle_padj),F,ifelse(Hypoxia$Muscle_padj<.1,T,F)),color= ifelse(is.na(Hypoxia$Muscle_padj),"gray",ifelse(Hypoxia$Muscle_padj<.1,spec_color(Hypoxia$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 127 | Wisp2 | -7.70e-01 | 0.0e+00 | -5.70e-01 | 1.1e-01 | 1.97e+00 | 0.0e+00 | -8.00e-01 | 1.1e-01 | 2.70e-01 | 6.8e-01 | -2.15e+00 | 0.0e+00 |
| 25 | Dcn | -1.70e-01 | 7.6e-01 | -3.60e-01 | 4.4e-01 | 1.80e-01 | 7.4e-01 | 8.00e-02 | 9.5e-01 | 1.20e-01 | 8.0e-01 | -2.08e+00 | 0.0e+00 |
| 8 | Atf3 | 6.90e-01 | 8.0e-02 | -3.70e-01 | 4.2e-01 | 1.40e-01 | 7.9e-01 | -8.40e-01 | 6.0e-02 | 3.70e-01 | 5.5e-01 | -2.01e+00 | 0.0e+00 |
| 54 | Ier3 | 1.09e+00 | 0.0e+00 | -6.00e-02 | 9.3e-01 | 1.01e+00 | 0.0e+00 | -4.40e-01 | 1.8e-01 | 1.00e-02 | 9.9e-01 | -1.95e+00 | 0.0e+00 |
| 5 | Ampd3 | 5.70e-01 | 0.0e+00 | 1.50e-01 | 5.3e-01 | 2.00e-02 | 9.7e-01 | 2.60e-01 | 7.3e-01 | 3.30e-01 | 1.4e-01 | -1.94e+00 | 0.0e+00 |
| 67 | Lox | 8.10e-01 | 0.0e+00 | -2.70e-01 | 6.0e-01 | 7.70e-01 | 5.0e-02 | -3.30e-01 | 5.1e-01 | 1.16e+00 | 0.0e+00 | -1.88e+00 | 0.0e+00 |
| 109 | Slc2a1 | 3.60e-01 | 6.0e-02 | 6.30e-01 | 2.0e-02 | 2.90e-01 | 5.8e-01 | 3.50e-01 | 4.4e-01 | -1.00e-02 | 9.9e-01 | -1.88e+00 | 0.0e+00 |
| 121 | Tmem45a | -2.70e-01 | 1.5e-01 | -2.40e-01 | 6.6e-01 | 3.30e-01 | 5.9e-01 | -9.00e-02 | 9.4e-01 | 1.00e-01 | 8.9e-01 | -1.81e+00 | 0.0e+00 |
| 10 | Bcan | 1.80e-01 | 6.6e-01 | 1.30e-01 | 8.2e-01 | 1.60e-01 | 7.3e-01 | -1.00e-01 | 9.3e-01 | 1.30e-01 | 8.8e-01 | -1.71e+00 | 1.0e-02 |
| 13 | Bhlhe40 | 7.20e-01 | 0.0e+00 | 2.00e-01 | 5.5e-01 | 9.50e-01 | 0.0e+00 | -1.07e+00 | 0.0e+00 | -7.90e-01 | 1.0e-02 | -1.60e+00 | 0.0e+00 |
| 61 | Kdelr3 | -1.00e-02 | 9.7e-01 | -3.30e-01 | 5.0e-01 | 1.80e-01 | 7.6e-01 | -2.00e-01 | 7.5e-01 | -2.20e-01 | 4.9e-01 | -1.57e+00 | 0.0e+00 |
| 101 | S100a4 | 8.00e-02 | 7.8e-01 | 1.20e-01 | 8.7e-01 | -5.00e-02 | 9.4e-01 | -3.20e-01 | 6.7e-01 | 2.90e-01 | 6.4e-01 | -1.57e+00 | 0.0e+00 |
| 20 | Cp | -1.00e-02 | 9.9e-01 | -1.10e-01 | 8.8e-01 | -7.00e-02 | 7.3e-01 | -2.60e-01 | 2.6e-01 | -9.00e-02 | 8.4e-01 | -1.54e+00 | 0.0e+00 |
| 34 | F3 | 1.20e+00 | 0.0e+00 | 1.90e-01 | 7.0e-01 | 1.40e-01 | 7.1e-01 | 6.10e-01 | 1.9e-01 | 7.00e-02 | 8.7e-01 | -1.49e+00 | 0.0e+00 |
| 2 | Ak4 | -9.00e-02 | 8.7e-01 | -1.20e-01 | 7.6e-01 | -2.50e-01 | 7.1e-01 | 4.00e-02 | 9.6e-01 | -6.00e-02 | 9.5e-01 | -1.46e+00 | 0.0e+00 |
| 116 | Tes | -8.00e-02 | 6.5e-01 | -6.00e-02 | 9.1e-01 | -3.50e-01 | 2.0e-01 | 0.00e+00 | 1.0e+00 | 1.40e-01 | 6.6e-01 | -1.45e+00 | 0.0e+00 |
| 44 | Gpc3 | 2.40e-01 | 2.0e-02 | 4.00e-02 | 9.2e-01 | 1.60e-01 | 3.9e-01 | -8.00e-02 | 9.5e-01 | 2.00e-02 | 9.9e-01 | -1.44e+00 | 0.0e+00 |
| 12 | Bgn | 1.60e-01 | 3.4e-01 | -1.10e-01 | 8.7e-01 | 2.50e-01 | 2.0e-01 | 1.70e-01 | 6.6e-01 | -6.00e-02 | 9.3e-01 | -1.39e+00 | 0.0e+00 |
| 64 | Klf6 | 4.60e-01 | 0.0e+00 | -2.70e-01 | 4.1e-01 | -3.60e-01 | 2.5e-01 | -1.80e-01 | 7.9e-01 | 5.90e-01 | 4.0e-02 | -1.32e+00 | 0.0e+00 |
| 42 | Gcnt2 | 3.70e-01 | 1.0e-02 | 1.50e-01 | 6.3e-01 | 1.10e-01 | 8.5e-01 | -1.80e-01 | 7.8e-01 | -2.70e-01 | 6.6e-01 | -1.27e+00 | 0.0e+00 |
| 106 | Selenbp1 | -6.00e-01 | 9.0e-02 | 2.10e-01 | 5.2e-01 | 3.30e-01 | 2.6e-01 | 1.10e+00 | 1.0e-02 | 1.80e-01 | 8.2e-01 | -1.27e+00 | 6.0e-02 |
| 19 | Col5a1 | -7.00e-02 | 7.3e-01 | -2.70e-01 | 6.0e-01 | 2.90e-01 | 1.8e-01 | 0.00e+00 | 1.0e+00 | 2.30e-01 | 5.1e-01 | -1.20e+00 | 0.0e+00 |
| 123 | Tpbg | 6.80e-01 | 0.0e+00 | -9.00e-02 | 6.8e-01 | -5.80e-01 | 0.0e+00 | -4.00e-01 | 2.5e-01 | -9.00e-02 | 9.2e-01 | -1.19e+00 | 2.0e-02 |
| 27 | Dusp1 | 1.14e+00 | 0.0e+00 | 8.00e-02 | 9.1e-01 | 1.10e+00 | 0.0e+00 | -5.60e-01 | 1.3e-01 | 6.80e-01 | 1.0e-01 | -1.15e+00 | 0.0e+00 |
| 3 | Akap12 | 3.20e-01 | 0.0e+00 | -1.70e-01 | 4.0e-01 | 2.50e-01 | 1.6e-01 | -9.00e-02 | 9.4e-01 | 8.00e-02 | 8.1e-01 | -1.13e+00 | 0.0e+00 |
| 40 | Gbe1 | -6.00e-02 | 7.6e-01 | -3.00e-02 | 9.4e-01 | -1.30e-01 | 6.6e-01 | -1.00e-02 | 9.9e-01 | 2.30e-01 | 6.5e-01 | -1.07e+00 | 0.0e+00 |
| 7 | Anxa2 | 1.30e-01 | 4.7e-01 | -3.00e-02 | 9.7e-01 | -1.60e-01 | 5.8e-01 | -8.00e-02 | 9.3e-01 | 2.20e-01 | 5.4e-01 | -1.05e+00 | 0.0e+00 |
| 18 | Cited2 | 2.10e-01 | 5.0e-02 | -1.50e-01 | 6.3e-01 | -5.30e-01 | 3.0e-02 | 3.80e-01 | 1.1e-01 | 1.50e-01 | 5.5e-01 | -1.03e+00 | 0.0e+00 |
| 104 | Sdc2 | -1.50e-01 | 3.8e-01 | -5.00e-02 | 9.3e-01 | -1.90e-01 | 5.3e-01 | -4.90e-01 | 0.0e+00 | -1.10e-01 | 8.1e-01 | -1.03e+00 | 0.0e+00 |
| 58 | Irs2 | 2.70e-01 | 1.0e-02 | -5.00e-02 | 8.9e-01 | -2.10e-01 | 6.9e-01 | 2.20e-01 | 6.7e-01 | -9.20e-01 | 0.0e+00 | -1.00e+00 | 0.0e+00 |
| 97 | Ptrf | -4.90e-01 | 0.0e+00 | -3.20e-01 | 5.0e-01 | -1.50e-01 | 7.7e-01 | -3.30e-01 | 6.5e-01 | -2.00e-01 | 4.2e-01 | -9.90e-01 | 0.0e+00 |
| 32 | Ets1 | -3.50e-01 | 0.0e+00 | -5.50e-01 | 2.0e-02 | -6.00e-02 | 9.0e-01 | -2.30e-01 | 5.2e-01 | 2.00e-02 | 9.7e-01 | -9.70e-01 | 0.0e+00 |
| 22 | Ctgf | 2.00e-01 | 4.0e-01 | -6.00e-02 | 9.3e-01 | 4.40e-01 | 0.0e+00 | 8.20e-01 | 4.0e-02 | 5.20e-01 | 1.7e-01 | -9.70e-01 | 0.0e+00 |
| 49 | Has1 | 1.63e+00 | 0.0e+00 | -1.10e-01 | 8.8e-01 | 1.17e+00 | 0.0e+00 | 1.60e-01 | NA | 1.60e-01 | 8.4e-01 | -9.60e-01 | 1.1e-01 |
| 29 | Eno2 | -2.30e-01 | 3.4e-01 | 1.50e-01 | 6.5e-01 | 1.30e-01 | 6.6e-01 | -2.20e-01 | 7.5e-01 | -1.90e-01 | 7.5e-01 | -9.20e-01 | 0.0e+00 |
| 50 | Hk1 | 1.50e-01 | 1.4e-01 | 8.00e-02 | 7.6e-01 | 1.50e-01 | 5.3e-01 | -1.00e-01 | 9.0e-01 | -3.00e-02 | 9.4e-01 | -8.70e-01 | 0.0e+00 |
| 71 | Nagk | -1.80e-01 | 4.5e-01 | -1.70e-01 | 5.7e-01 | 6.70e-01 | 0.0e+00 | -6.00e-02 | 8.9e-01 | -1.40e-01 | 8.0e-01 | -8.60e-01 | 1.0e-02 |
| 23 | Cxcr4 | -7.00e-01 | 0.0e+00 | -6.30e-01 | 3.0e-02 | -2.50e-01 | 6.0e-01 | 3.80e-01 | 4.9e-01 | -2.30e-01 | 6.5e-01 | -8.30e-01 | 0.0e+00 |
| 79 | Pam | 2.00e-02 | 8.7e-01 | 3.00e-02 | 9.4e-01 | -2.00e-02 | 9.5e-01 | -4.00e-02 | 9.4e-01 | 7.00e-02 | 8.2e-01 | -8.10e-01 | 0.0e+00 |
| 81 | Pdgfb | -1.12e+00 | 0.0e+00 | -3.90e-01 | 6.0e-02 | 1.15e+00 | 0.0e+00 | -1.90e-01 | 8.5e-01 | -2.60e-01 | 2.1e-01 | -7.90e-01 | 0.0e+00 |
| 128 | Wsb1 | 2.10e-01 | 1.0e-01 | -3.00e-02 | 9.7e-01 | 2.00e-02 | 9.8e-01 | 1.10e-01 | 8.1e-01 | 2.00e-01 | 5.9e-01 | -7.80e-01 | 1.0e-02 |
| 14 | Btg1 | 4.70e-01 | 1.0e-02 | -2.00e-02 | 9.8e-01 | -3.10e-01 | 5.6e-01 | 6.00e-02 | 9.4e-01 | 6.20e-01 | 0.0e+00 | -7.70e-01 | 0.0e+00 |
| 118 | Tgfbi | 1.50e-01 | 2.7e-01 | 1.30e-01 | 7.5e-01 | -1.00e-02 | 9.7e-01 | -9.00e-02 | 8.2e-01 | 2.50e-01 | 3.7e-01 | -7.50e-01 | 0.0e+00 |
| 36 | Fos | 1.01e+00 | 0.0e+00 | -6.40e-01 | 1.0e-02 | 4.60e-01 | 3.1e-01 | 3.90e-01 | 6.0e-01 | 3.20e-01 | NA | -7.50e-01 | 2.4e-01 |
| 89 | Pkp1 | 1.15e+00 | 0.0e+00 | -2.10e-01 | 7.3e-01 | -1.25e+00 | 0.0e+00 | 5.00e-02 | NA | 9.00e-02 | NA | -7.40e-01 | NA |
| 80 | Pck1 | -6.50e-01 | 1.0e-02 | 0.00e+00 | 1.0e+00 | 1.90e-01 | 7.9e-01 | 9.00e-02 | 8.4e-01 | -2.00e-02 | 9.9e-01 | -7.40e-01 | 2.4e-01 |
| 33 | Ext1 | -2.00e-02 | 9.1e-01 | -2.00e-01 | 4.9e-01 | 1.11e+00 | 0.0e+00 | 7.50e-01 | 0.0e+00 | -3.00e-01 | 9.0e-02 | -6.60e-01 | 0.0e+00 |
| 87 | Pgm2 | -2.90e-01 | 0.0e+00 | 7.00e-02 | 8.5e-01 | 5.90e-01 | 0.0e+00 | -8.00e-02 | 8.8e-01 | 1.10e-01 | 7.7e-01 | -6.40e-01 | 1.0e-02 |
| 9 | B3galt6 | -1.40e-01 | 5.5e-01 | 0.00e+00 | 1.0e+00 | 9.00e-02 | 8.0e-01 | 1.30e-01 | 8.0e-01 | -4.80e-01 | 6.0e-02 | -6.20e-01 | 3.0e-02 |
| 93 | Ppfia4 | 1.60e-01 | 6.1e-01 | -3.00e-02 | 9.5e-01 | 4.50e-01 | 2.9e-01 | -1.00e-01 | 9.3e-01 | -3.00e-01 | 5.5e-01 | -6.10e-01 | 5.0e-02 |
| 65 | Klf7 | 1.40e-01 | 7.8e-01 | -7.00e-02 | 9.3e-01 | -2.50e-01 | 5.4e-01 | 8.00e-02 | 9.5e-01 | -2.30e-01 | 5.3e-01 | -6.00e-01 | 5.0e-02 |
| 15 | Cav1 | 2.50e-01 | 4.0e-02 | -4.00e-02 | 9.3e-01 | 6.80e-01 | 0.0e+00 | -2.00e-01 | NA | 2.50e-01 | 4.1e-01 | -6.00e-01 | 0.0e+00 |
| 70 | Myh9 | 1.00e-01 | 5.9e-01 | -2.60e-01 | 5.5e-01 | 9.90e-01 | 0.0e+00 | -2.20e-01 | 4.6e-01 | -1.00e-02 | 9.9e-01 | -6.00e-01 | 1.0e-02 |
| 76 | Nr3c1 | -4.40e-01 | 3.0e-02 | -3.70e-01 | 2.3e-01 | -2.70e-01 | 5.3e-01 | -8.10e-01 | 0.0e+00 | -7.30e-01 | 1.0e-02 | -5.50e-01 | 1.0e-02 |
| 60 | Jun | 4.20e-01 | 6.0e-02 | -3.60e-01 | 2.2e-01 | -7.30e-01 | 0.0e+00 | -9.30e-01 | 2.0e-02 | 6.40e-01 | 8.0e-02 | -5.30e-01 | 2.0e-02 |
| 94 | Ppp1r15a | 7.40e-01 | 0.0e+00 | 3.30e-01 | 2.5e-01 | 2.80e-01 | 4.6e-01 | -8.00e-02 | 9.3e-01 | 8.40e-01 | 1.0e-02 | -4.90e-01 | 9.0e-02 |
| 90 | Plaur | 1.33e+00 | 0.0e+00 | -1.60e-01 | NA | 4.30e-01 | 1.8e-01 | 4.30e-01 | 5.1e-01 | 1.50e-01 | 6.9e-01 | -4.70e-01 | 2.8e-01 |
| 112 | Slc6a6 | 6.90e-01 | 0.0e+00 | -3.60e-01 | 1.0e-01 | -1.40e-01 | 8.1e-01 | 2.90e-01 | 6.1e-01 | -1.41e+00 | 0.0e+00 | -4.50e-01 | 1.7e-01 |
| 114 | Stc1 | -1.50e-01 | 2.8e-01 | -1.70e-01 | 7.3e-01 | 1.20e-01 | 8.3e-01 | -1.75e+00 | 0.0e+00 | 2.50e-01 | 4.5e-01 | -4.30e-01 | 2.4e-01 |
| 1 | Adora2b | 9.20e-01 | 0.0e+00 | -3.60e-01 | 3.1e-01 | 5.80e-01 | 2.2e-01 | -1.80e-01 | 8.6e-01 | -7.00e-02 | 9.4e-01 | -3.30e-01 | 5.5e-01 |
| 28 | Efna1 | 2.60e-01 | 2.6e-01 | 4.00e-02 | 9.5e-01 | -1.20e-01 | 8.1e-01 | -7.60e-01 | 1.0e-02 | 8.00e-02 | 9.0e-01 | -3.00e-01 | 1.7e-01 |
| 122 | Tnfaip3 | 2.10e-01 | 5.3e-01 | -2.20e-01 | 6.7e-01 | -2.70e-01 | 4.6e-01 | 7.90e-01 | 2.0e-02 | -3.30e-01 | 4.4e-01 | -3.00e-01 | 4.5e-01 |
| 45 | Gpc4 | 3.00e-01 | 0.0e+00 | -2.00e-02 | 9.8e-01 | 1.05e+00 | 0.0e+00 | -3.30e-01 | 0.0e+00 | 5.00e-02 | 9.0e-01 | -2.90e-01 | 1.0e-01 |
| 73 | Ndst1 | 2.60e-01 | 3.2e-01 | -1.20e-01 | 7.5e-01 | 6.30e-01 | 4.0e-02 | -3.90e-01 | 4.8e-01 | -1.30e-01 | 7.3e-01 | -2.60e-01 | 3.9e-01 |
| 52 | Hmox1 | 6.40e-01 | 1.0e-02 | -1.10e-01 | 8.6e-01 | -4.90e-01 | 4.0e-02 | -2.00e-01 | 6.2e-01 | 2.90e-01 | 3.7e-01 | -2.60e-01 | 4.8e-01 |
| 103 | Scarb1 | -1.60e-01 | 5.4e-01 | 1.00e-01 | 8.9e-01 | 1.22e+00 | 0.0e+00 | 1.10e-01 | 8.4e-01 | -1.80e-01 | 5.5e-01 | -2.40e-01 | 5.2e-01 |
| 24 | Cyr61 | 5.00e-02 | 9.4e-01 | -5.10e-01 | 1.6e-01 | 8.80e-01 | 3.0e-02 | -8.40e-01 | 2.0e-02 | 1.82e+00 | 0.0e+00 | -2.40e-01 | 4.9e-01 |
| 117 | Tgfb3 | -3.90e-01 | 4.0e-02 | -6.50e-01 | 3.0e-02 | -2.60e-01 | 2.1e-01 | 1.40e-01 | 8.6e-01 | -1.00e-01 | 8.8e-01 | -2.00e-01 | 1.8e-01 |
| 91 | Pnrc1 | 3.50e-01 | 1.0e-02 | -6.00e-02 | 8.9e-01 | 7.00e-01 | 0.0e+00 | 4.00e-02 | 9.3e-01 | 3.70e-01 | 1.6e-01 | -1.80e-01 | 4.1e-01 |
| 119 | Tgm2 | 8.00e-02 | 6.2e-01 | -1.00e-02 | 9.9e-01 | 1.84e+00 | 0.0e+00 | -2.80e-01 | 2.0e-01 | 9.10e-01 | 0.0e+00 | -1.10e-01 | 6.4e-01 |
| 53 | Hspa5 | -1.80e-01 | 2.2e-01 | -6.00e-02 | 9.0e-01 | 9.70e-01 | 0.0e+00 | -6.00e-02 | 9.0e-01 | 3.30e-01 | 1.0e-01 | -9.00e-02 | 7.6e-01 |
| 56 | Ilvbl | 1.30e-01 | 6.9e-01 | 1.30e-01 | 6.7e-01 | 6.30e-01 | 0.0e+00 | 1.10e-01 | 7.6e-01 | -2.70e-01 | 4.2e-01 | -2.00e-02 | 9.5e-01 |
| 51 | Hk2 | 1.01e+00 | 0.0e+00 | -2.70e-01 | 2.8e-01 | 7.10e-01 | 0.0e+00 | -6.00e-01 | 1.6e-01 | 6.80e-01 | 2.0e-02 | 1.00e-02 | 9.7e-01 |
| 125 | Tpst2 | 3.70e-01 | 7.0e-02 | 1.90e-01 | 7.3e-01 | 7.00e-02 | 8.9e-01 | 6.90e-01 | 2.0e-02 | 3.00e-02 | 9.6e-01 | 4.00e-02 | 9.0e-01 |
| 55 | Igfbp1 | -2.60e-01 | 5.2e-01 | 1.10e-01 | 8.4e-01 | -2.70e-01 | 7.3e-01 | 1.44e+00 | 0.0e+00 | -1.00e-02 | NA | 1.20e-01 | NA |
| 6 | Angptl4 | 4.90e-01 | 2.1e-01 | 2.40e-01 | 5.6e-01 | 7.80e-01 | 0.0e+00 | 3.00e-01 | 1.4e-01 | 1.10e-01 | 8.1e-01 | 1.20e-01 | 7.7e-01 |
| 126 | Ugp2 | 0.00e+00 | 9.8e-01 | -1.70e-01 | 3.5e-01 | 2.90e-01 | 5.0e-02 | -7.90e-01 | 0.0e+00 | 3.00e-02 | 9.6e-01 | 1.40e-01 | 6.9e-01 |
| 11 | Bcl2 | -9.00e-02 | 8.4e-01 | -4.40e-01 | 2.8e-01 | -2.10e-01 | 7.3e-01 | -2.00e-02 | 9.9e-01 | -9.90e-01 | 1.0e-02 | 1.50e-01 | 8.3e-01 |
| 59 | Isg20 | -1.50e-01 | 4.9e-01 | -1.20e-01 | 8.7e-01 | 1.18e+00 | 0.0e+00 | 5.00e-02 | 9.6e-01 | -2.00e-01 | 6.5e-01 | 1.70e-01 | 7.4e-01 |
| 78 | P4ha2 | 9.30e-01 | 0.0e+00 | 2.00e-01 | 6.9e-01 | -1.30e-01 | 7.8e-01 | -2.00e-01 | 6.3e-01 | 1.80e-01 | 7.6e-01 | 2.60e-01 | 2.3e-01 |
| 72 | Ndrg1 | 3.10e-01 | 2.0e-02 | 3.10e-01 | 4.0e-02 | 1.87e+00 | 0.0e+00 | 2.70e-01 | 5.3e-01 | 8.10e-01 | 0.0e+00 | 3.20e-01 | 2.6e-01 |
| 92 | Ppargc1a | -1.80e-01 | 6.5e-01 | -1.30e-01 | 8.4e-01 | 2.00e-01 | 7.5e-01 | 2.46e+00 | 0.0e+00 | -8.00e-02 | 9.2e-01 | 3.30e-01 | 1.6e-01 |
| 48 | Gys1 | 1.20e-01 | 5.1e-01 | -2.00e-02 | 9.6e-01 | -4.00e-01 | 1.0e-01 | 7.60e-01 | 0.0e+00 | 7.00e-02 | 8.0e-01 | 3.70e-01 | 2.0e-02 |
| 77 | P4ha1 | -7.10e-01 | 0.0e+00 | -6.00e-01 | 3.0e-02 | -1.04e+00 | 0.0e+00 | -8.20e-01 | 0.0e+00 | -7.70e-01 | 0.0e+00 | 4.20e-01 | 1.7e-01 |
| 37 | Fosl2 | 1.14e+00 | 0.0e+00 | -1.80e-01 | 7.7e-01 | -3.80e-01 | 3.1e-01 | 3.00e-01 | 7.2e-01 | 4.00e-01 | 4.2e-01 | 4.40e-01 | 2.2e-01 |
| 115 | Stc2 | 2.80e-01 | 1.4e-01 | -3.10e-01 | 5.2e-01 | 1.14e+00 | 0.0e+00 | -2.20e-01 | NA | -4.00e-02 | 9.5e-01 | 4.40e-01 | 1.1e-01 |
| 100 | Rragd | -5.30e-01 | 2.0e-02 | -1.00e-01 | 8.5e-01 | -3.70e-01 | 1.1e-01 | -1.15e+00 | 0.0e+00 | -6.80e-01 | 1.8e-01 | 4.90e-01 | 1.0e-02 |
| 99 | Rora | 1.70e-01 | 7.4e-01 | 2.00e-02 | 9.9e-01 | 1.67e+00 | 0.0e+00 | 4.80e-01 | 3.5e-01 | 9.00e-01 | 1.0e-02 | 5.00e-01 | 9.0e-02 |
| 84 | Pgf | 1.78e+00 | 0.0e+00 | 7.20e-01 | 1.0e-02 | 2.00e-01 | 6.4e-01 | -1.20e-01 | NA | 6.60e-01 | 6.0e-02 | 5.10e-01 | 2.8e-01 |
| 41 | Gck | -2.30e-01 | 5.8e-01 | 0.00e+00 | 1.0e+00 | -4.00e-01 | 5.7e-01 | -1.30e+00 | 0.0e+00 | 1.00e-01 | NA | 6.30e-01 | NA |
| 107 | Serpine1 | 8.00e-01 | 0.0e+00 | 1.60e-01 | 7.8e-01 | -1.21e+00 | 0.0e+00 | 1.34e+00 | 0.0e+00 | 4.53e+00 | 0.0e+00 | 6.40e-01 | 3.0e-02 |
| 108 | Siah2 | 3.30e-01 | 1.8e-01 | 7.00e-02 | 8.9e-01 | 6.00e-02 | 9.2e-01 | -3.00e-02 | 9.6e-01 | 2.00e-02 | 9.8e-01 | 6.50e-01 | 0.0e+00 |
| 111 | Slc37a4 | 1.30e-01 | 4.8e-01 | 1.70e-01 | 6.9e-01 | -5.80e-01 | 0.0e+00 | 4.50e-01 | 3.0e-02 | -3.30e-01 | 3.4e-01 | 7.00e-01 | 0.0e+00 |
| 57 | Inha | 3.80e-01 | 2.5e-01 | -1.40e-01 | 7.6e-01 | 1.08e+00 | 0.0e+00 | 1.00e-01 | NA | 4.00e-02 | 9.6e-01 | 7.20e-01 | 7.0e-02 |
| 68 | Maff | 1.35e+00 | 0.0e+00 | 3.00e-01 | 4.7e-01 | 1.77e+00 | 0.0e+00 | 6.00e-02 | 9.6e-01 | 9.40e-01 | 0.0e+00 | 7.60e-01 | 7.0e-02 |
| 105 | Sdc4 | 6.80e-01 | 0.0e+00 | 2.70e-01 | 4.9e-01 | 4.00e-01 | 2.4e-01 | 1.09e+00 | 0.0e+00 | 7.60e-01 | 7.0e-02 | 8.10e-01 | 0.0e+00 |
| 74 | Nedd4l | 6.30e-01 | 1.0e-02 | 2.00e-02 | 9.8e-01 | -2.80e-01 | 3.6e-01 | 1.40e-01 | 7.4e-01 | -3.60e-01 | 1.7e-01 | 8.20e-01 | 0.0e+00 |
| 43 | Glrx | 4.30e-01 | 4.0e-02 | 1.10e-01 | 8.7e-01 | 7.20e-01 | 1.0e-02 | -1.10e-01 | 8.6e-01 | 5.50e-01 | 4.0e-02 | 8.30e-01 | 1.0e-02 |
| 35 | Fam162a | -2.30e-01 | 2.2e-01 | 3.90e-01 | 8.0e-02 | -7.00e-02 | 8.9e-01 | -1.40e-01 | 8.5e-01 | 4.00e-02 | 9.5e-01 | 8.40e-01 | 0.0e+00 |
| 85 | Pgk1 | 1.70e-01 | 5.2e-01 | 4.00e-02 | 9.4e-01 | 3.40e-01 | 5.0e-02 | 2.30e-01 | 5.4e-01 | 1.30e-01 | 7.6e-01 | 8.40e-01 | 0.0e+00 |
| 63 | Kif5a | 2.90e-01 | 3.0e-01 | 3.00e-02 | 9.5e-01 | 1.04e+00 | 0.0e+00 | 4.00e-02 | 9.7e-01 | -2.60e-01 | 5.5e-01 | 9.00e-01 | 0.0e+00 |
| 66 | Ldha | -7.00e-02 | 7.7e-01 | 1.90e-01 | 3.0e-01 | 6.40e-01 | 1.0e-02 | 2.40e-01 | 4.6e-01 | 3.10e-01 | 1.5e-01 | 9.00e-01 | 0.0e+00 |
| 4 | Aldoa | 4.00e-02 | 8.6e-01 | 2.10e-01 | 2.6e-01 | 1.40e-01 | 6.6e-01 | 6.30e-01 | 0.0e+00 | 1.70e-01 | 6.8e-01 | 9.10e-01 | 0.0e+00 |
| 86 | Pgm1 | -3.00e-02 | 9.4e-01 | 1.00e-01 | 7.9e-01 | -3.80e-01 | 5.0e-02 | 5.00e-02 | 8.8e-01 | -3.60e-01 | 3.9e-01 | 9.40e-01 | 0.0e+00 |
| 124 | Tpi1 | -2.00e-02 | 9.5e-01 | 1.70e-01 | 7.0e-01 | 3.30e-01 | 6.0e-02 | 0.00e+00 | 1.0e+00 | -1.20e-01 | 8.0e-01 | 1.00e+00 | 0.0e+00 |
| 30 | Eno3 | -7.80e-01 | 0.0e+00 | 6.00e-02 | 9.3e-01 | -8.80e-01 | 0.0e+00 | -2.50e-01 | 6.8e-01 | -6.10e-01 | 1.6e-01 | 1.06e+00 | 0.0e+00 |
| 98 | Pygm | -1.50e-01 | 7.1e-01 | 2.70e-01 | 1.0e-01 | 5.00e-01 | 7.0e-02 | -3.00e-01 | 7.2e-01 | -5.50e-01 | 2.0e-01 | 1.07e+00 | 0.0e+00 |
| 110 | Slc2a5 | 7.10e-01 | 6.0e-02 | -2.00e-02 | 9.7e-01 | -8.60e-01 | 0.0e+00 | -4.40e-01 | 1.6e-01 | 1.16e+00 | 0.0e+00 | 1.08e+00 | 0.0e+00 |
| 39 | Gapdh | -3.00e-01 | 5.4e-01 | -4.00e-02 | 9.6e-01 | -1.30e-01 | 8.6e-01 | 6.90e-01 | 1.7e-01 | 1.30e-01 | NA | 1.08e+00 | 1.0e-02 |
| 120 | Tiparp | 2.70e-01 | 1.9e-01 | 2.80e-01 | 4.8e-01 | 5.50e-01 | 1.9e-01 | -2.80e-01 | 5.9e-01 | 8.70e-01 | 0.0e+00 | 1.09e+00 | 0.0e+00 |
| 96 | Prdx5 | 1.70e-01 | 5.4e-01 | 3.50e-01 | 2.8e-01 | 4.00e-01 | 3.8e-01 | 0.00e+00 | 1.0e+00 | 1.00e-01 | 8.6e-01 | 1.09e+00 | 0.0e+00 |
| 46 | Gpi | 2.20e-01 | 2.7e-01 | 1.40e-01 | 6.8e-01 | 4.00e-02 | 9.3e-01 | -5.00e-02 | 9.4e-01 | 1.40e-01 | 6.0e-01 | 1.16e+00 | 0.0e+00 |
| 102 | Sap30 | -4.10e-01 | 4.0e-01 | -4.00e-02 | 9.7e-01 | 6.40e-01 | 8.0e-02 | 4.00e-01 | 5.6e-01 | -4.90e-01 | 4.0e-01 | 1.17e+00 | 0.0e+00 |
| 47 | Grhpr | 2.80e-01 | 1.2e-01 | 2.70e-01 | 4.8e-01 | -2.50e-01 | 5.9e-01 | -3.00e-01 | 5.1e-01 | -5.30e-01 | 1.0e-01 | 1.22e+00 | 0.0e+00 |
| 88 | Phkg1 | -8.80e-01 | 3.0e-02 | 8.00e-02 | 8.8e-01 | -3.00e-02 | 9.7e-01 | -3.60e-01 | NA | -9.90e-01 | 2.0e-02 | 1.23e+00 | 0.0e+00 |
| 17 | Chst3 | 8.40e-01 | 0.0e+00 | 6.10e-01 | 0.0e+00 | -3.90e-01 | 7.0e-02 | 8.10e-01 | 4.0e-02 | 2.10e-01 | 6.0e-01 | 1.31e+00 | 0.0e+00 |
| 38 | Foxo3 | 5.00e-01 | 1.3e-01 | 1.00e-02 | 9.9e-01 | -1.30e-01 | 7.7e-01 | 1.10e-01 | 8.9e-01 | 7.30e-01 | 2.0e-02 | 1.32e+00 | 0.0e+00 |
| 21 | Csrp2 | 2.20e-01 | 3.4e-01 | 3.20e-01 | 4.4e-01 | -8.60e-01 | 0.0e+00 | -4.00e-02 | 9.7e-01 | 8.00e-01 | 7.0e-02 | 1.37e+00 | 0.0e+00 |
| 113 | Stbd1 | -7.60e-01 | 0.0e+00 | -4.40e-01 | 1.4e-01 | -6.50e-01 | 0.0e+00 | -1.59e+00 | 0.0e+00 | -2.10e-01 | 5.3e-01 | 1.37e+00 | 0.0e+00 |
| 62 | Kdm3a | 7.00e-02 | 7.3e-01 | 1.00e-02 | 9.8e-01 | 2.70e-01 | 4.0e-02 | 3.00e-02 | 9.6e-01 | 1.40e-01 | 6.8e-01 | 1.41e+00 | 0.0e+00 |
| 129 | Zfp36 | 9.40e-01 | 0.0e+00 | 3.70e-01 | 2.6e-01 | -1.50e-01 | 6.9e-01 | 3.30e-01 | 3.4e-01 | 8.20e-01 | 5.0e-02 | 1.46e+00 | 0.0e+00 |
| 82 | Pfkfb3 | 1.40e+00 | 0.0e+00 | -2.50e-01 | 2.1e-01 | 4.60e-01 | 2.3e-01 | 9.30e-01 | 0.0e+00 | 5.30e-01 | 1.4e-01 | 1.52e+00 | 0.0e+00 |
| 75 | Nfil3 | 1.02e+00 | 0.0e+00 | 1.00e-02 | 9.9e-01 | 9.90e-01 | 0.0e+00 | 6.00e-02 | 9.4e-01 | 1.18e+00 | 0.0e+00 | 1.66e+00 | 0.0e+00 |
| 83 | Pgam2 | 8.00e-02 | 8.7e-01 | 2.40e-01 | 6.0e-01 | -4.00e-01 | 3.2e-01 | 4.90e-01 | 4.3e-01 | -6.50e-01 | 1.5e-01 | 1.85e+00 | 0.0e+00 |
| 31 | Errfi1 | 1.54e+00 | 0.0e+00 | 5.00e-01 | 9.0e-02 | 1.60e-01 | 6.0e-01 | 5.10e-01 | 3.0e-02 | 1.59e+00 | 0.0e+00 | 2.18e+00 | 0.0e+00 |
| 16 | Cdkn1a | 2.14e+00 | 0.0e+00 | 1.85e+00 | 0.0e+00 | 9.20e-01 | 0.0e+00 | 3.34e+00 | 0.0e+00 | 2.30e+00 | 0.0e+00 | 2.54e+00 | 0.0e+00 |
| 95 | Ppp1r3c | -6.60e-01 | 0.0e+00 | -2.00e-01 | 3.8e-01 | -5.40e-01 | 2.5e-01 | 1.71e+00 | 0.0e+00 | -7.30e-01 | 1.5e-01 | 2.84e+00 | 0.0e+00 |
| 69 | Mt2a | 3.51e+00 | 0.0e+00 | 2.29e+00 | 0.0e+00 | -9.40e-01 | 0.0e+00 | 8.90e-01 | 1.0e-02 | 3.40e+00 | 0.0e+00 | 2.93e+00 | 0.0e+00 |
| 26 | Ddit4 | 1.33e+00 | 0.0e+00 | 4.70e-01 | 1.2e-01 | -2.40e-01 | 6.7e-01 | 8.10e-01 | 0.0e+00 | 7.70e-01 | 6.0e-02 | 3.80e+00 | 0.0e+00 |
Hypoxia %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S14. Relative changes in the expression of genes involved in hypoxia response after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))AAMet %>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>% kable(caption = "Supplementary Table 15. Relative changes in the expression of genes involved in amino acid metabolism after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(AAMet$Adrenal_padj),F,ifelse(AAMet$Adrenal_padj<.1,T,F)),color= ifelse(is.na(AAMet$Adrenal_padj),"gray",ifelse(AAMet$Adrenal_padj<.1,spec_color(AAMet$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(AAMet$HT_padj),F,ifelse(AAMet$HT_padj<.1,T,F)),color= ifelse(is.na(AAMet$HT_padj),"gray",ifelse(AAMet$HT_padj<.1,spec_color(AAMet$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(AAMet$Liver_padj),F,ifelse(AAMet$Liver_padj<.1,T,F)),color= ifelse(is.na(AAMet$Liver_padj),"gray",ifelse(AAMet$Liver_padj<.1,spec_color(AAMet$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(AAMet$Lung_padj),F,ifelse(AAMet$Lung_padj<.1,T,F)),color= ifelse(is.na(AAMet$Lung_padj),"gray",ifelse(AAMet$Lung_padj <.1,spec_color(AAMet$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(AAMet$Adipose_padj),F,ifelse(AAMet$Adipose_padj<.1,T,F)),color= ifelse(is.na(AAMet$Adipose_padj),"gray",ifelse(AAMet$Adipose_padj<.1, spec_color(AAMet$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(AAMet$Muscle_padj),F,ifelse(AAMet$Muscle_padj<.1,T,F)),color= ifelse(is.na(AAMet$Muscle_padj),"gray",ifelse(AAMet$Muscle_padj<.1,spec_color(AAMet$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 46 | Duox2 | -1.60e-01 | 7.4e-01 | 1.70e-01 | NA | -4.00e-02 | 9.7e-01 | 9.10e-01 | 6.0e-02 | -3.20e-01 | 6.3e-01 | -2.41e+00 | 0.0e+00 |
| 15 | Arg1 | 6.00e-02 | 8.8e-01 | 4.00e-02 | 9.7e-01 | -7.50e-01 | 2.1e-01 | 9.60e-01 | 0.0e+00 | 6.00e-02 | 9.4e-01 | -2.05e+00 | 0.0e+00 |
| 90 | Pmp22 | 1.00e-02 | 9.5e-01 | 1.70e-01 | 7.0e-01 | 1.30e-01 | 6.1e-01 | -1.10e-01 | 9.3e-01 | 9.00e-02 | 9.0e-01 | -1.72e+00 | 0.0e+00 |
| 38 | Crym | -8.10e-01 | 1.0e-02 | 4.40e-01 | 2.4e-01 | 2.30e-01 | 5.9e-01 | -3.80e-01 | 2.3e-01 | -3.90e-01 | 5.1e-01 | -1.45e+00 | 0.0e+00 |
| 11 | Aldh18a1 | -2.00e-01 | 2.5e-01 | -1.40e-01 | 6.2e-01 | 4.00e-01 | 2.3e-01 | -1.60e-01 | 8.7e-01 | -3.60e-01 | 2.2e-01 | -1.38e+00 | 0.0e+00 |
| 149 | Slc44a1 | -2.60e-01 | 2.3e-01 | 1.30e-01 | 5.1e-01 | -4.50e-01 | 3.2e-01 | -1.50e-01 | 8.2e-01 | -9.00e-02 | 8.2e-01 | -1.33e+00 | 0.0e+00 |
| 42 | Dio1 | -7.10e-01 | 8.0e-02 | -4.00e-02 | 9.5e-01 | -5.50e-01 | 3.8e-01 | -5.00e-02 | 9.2e-01 | -9.00e-02 | NA | -1.17e+00 | 7.0e-02 |
| 106 | Rimkla | 2.10e-01 | 7.0e-01 | -3.80e-01 | 3.1e-01 | -8.00e-02 | NA | 1.60e-01 | NA | -1.30e-01 | 8.8e-01 | -1.15e+00 | 8.0e-02 |
| 18 | Asns | 1.20e-01 | 3.8e-01 | 3.00e-02 | 9.4e-01 | 9.90e-01 | 0.0e+00 | 7.00e-01 | 1.0e-02 | 1.50e-01 | 6.9e-01 | -1.15e+00 | 0.0e+00 |
| 61 | Hdc | -9.60e-01 | 0.0e+00 | 1.00e-02 | 9.9e-01 | 2.40e-01 | 6.4e-01 | -1.30e-01 | 8.7e-01 | -7.60e-01 | 0.0e+00 | -1.12e+00 | 1.0e-02 |
| 76 | Nat8l | -8.70e-01 | 1.0e-02 | -7.00e-02 | 9.0e-01 | -2.90e-01 | 5.6e-01 | 2.80e-01 | NA | -5.20e-01 | 7.0e-02 | -1.12e+00 | 1.0e-02 |
| 143 | Slc25a15 | 1.70e-01 | 3.7e-01 | 9.00e-02 | 8.8e-01 | -6.70e-01 | 2.0e-02 | 2.29e+00 | 0.0e+00 | -2.60e-01 | 4.5e-01 | -1.06e+00 | 0.0e+00 |
| 10 | Aim1 | -3.60e-01 | 5.0e-02 | -3.80e-01 | 2.2e-01 | 2.50e-01 | 4.2e-01 | 1.20e-01 | 6.2e-01 | -1.60e-01 | 7.0e-01 | -1.04e+00 | 0.0e+00 |
| 107 | Rimklb | -1.60e-01 | 5.7e-01 | 3.00e-02 | 9.5e-01 | -7.00e-02 | 8.3e-01 | 1.80e-01 | NA | 2.80e-01 | 6.6e-01 | -1.04e+00 | 9.0e-02 |
| 35 | Cdo1 | 1.05e+00 | 0.0e+00 | 2.20e-01 | 5.3e-01 | -4.00e-01 | 2.0e-01 | 3.70e-01 | 1.3e-01 | -1.40e-01 | 6.4e-01 | -1.02e+00 | 1.0e-02 |
| 78 | Nnmt | -1.60e-01 | 6.8e-01 | 2.10e-01 | 7.1e-01 | -2.40e-01 | 4.8e-01 | 7.70e-01 | 0.0e+00 | -1.00e-02 | 9.9e-01 | -1.02e+00 | 2.0e-02 |
| 88 | Phgdh | -3.80e-01 | 3.8e-01 | 4.00e-02 | 9.3e-01 | 4.80e-01 | 2.0e-02 | 4.00e-01 | 5.7e-01 | -2.00e-01 | 6.3e-01 | -9.50e-01 | 5.0e-02 |
| 92 | Ppm1k | -1.60e-01 | 6.5e-01 | -7.00e-02 | 9.1e-01 | -4.10e-01 | 4.1e-01 | 9.70e-01 | 0.0e+00 | 1.30e-01 | 8.3e-01 | -9.50e-01 | 0.0e+00 |
| 64 | Hpd | -3.70e-01 | 3.5e-01 | 4.00e-02 | 9.5e-01 | -5.90e-01 | 3.4e-01 | 1.80e-01 | 6.2e-01 | -1.60e-01 | 8.2e-01 | -9.40e-01 | 7.0e-02 |
| 159 | Tph1 | -3.20e-01 | 5.2e-01 | 1.40e-01 | 8.1e-01 | 5.30e-01 | 4.3e-01 | -4.00e-02 | NA | -1.17e+00 | 0.0e+00 | -9.00e-01 | 5.0e-02 |
| 27 | Bcat1 | 4.30e-01 | 7.0e-02 | 1.70e-01 | 5.0e-01 | 1.15e+00 | 0.0e+00 | 0.00e+00 | 1.0e+00 | 4.30e-01 | 2.7e-01 | -8.70e-01 | 2.0e-02 |
| 54 | Gatm | -2.70e-01 | 5.0e-02 | 1.80e-01 | 4.5e-01 | 1.10e-01 | 8.7e-01 | 7.00e-02 | 9.1e-01 | 1.10e-01 | 8.6e-01 | -8.20e-01 | 0.0e+00 |
| 2 | Aass | -4.50e-01 | 3.3e-01 | -2.80e-01 | 4.2e-01 | -8.00e-02 | 9.2e-01 | 1.27e+00 | 0.0e+00 | -3.10e-01 | 6.1e-01 | -7.90e-01 | 2.4e-01 |
| 65 | Hykk | -1.18e+00 | 0.0e+00 | -2.50e-01 | 6.1e-01 | -5.00e-01 | 4.4e-01 | -6.70e-01 | 2.0e-02 | -4.90e-01 | 3.8e-01 | -7.80e-01 | 2.7e-01 |
| 152 | Smo | -7.10e-01 | 0.0e+00 | -6.00e-02 | 9.1e-01 | -5.10e-01 | 1.0e-02 | -3.80e-01 | 2.0e-01 | -4.40e-01 | 9.0e-02 | -7.30e-01 | 0.0e+00 |
| 85 | Pah | -3.80e-01 | 2.0e-01 | 4.00e-02 | 9.5e-01 | -7.30e-01 | 1.0e-02 | 6.60e-01 | 0.0e+00 | -1.30e-01 | 8.8e-01 | -7.30e-01 | NA |
| 60 | Gsr | 2.00e-02 | 9.2e-01 | -6.00e-02 | 8.8e-01 | -4.50e-01 | 0.0e+00 | -2.00e-02 | 9.8e-01 | -1.90e-01 | 5.2e-01 | -7.20e-01 | 0.0e+00 |
| 47 | Eef1e1 | 2.60e-01 | 4.2e-01 | 1.10e-01 | 8.8e-01 | 5.70e-01 | 1.9e-01 | 2.20e-01 | 7.0e-01 | 2.30e-01 | 6.9e-01 | -7.00e-01 | 0.0e+00 |
| 89 | Pipox | -9.20e-01 | 1.0e-02 | -2.20e-01 | 6.6e-01 | -2.70e-01 | 5.2e-01 | -3.90e-01 | 2.0e-02 | -2.80e-01 | 6.9e-01 | -6.10e-01 | NA |
| 137 | Sds | -1.10e-01 | NA | 1.10e-01 | 8.7e-01 | -3.60e-01 | 6.3e-01 | 2.37e+00 | 0.0e+00 | 6.00e-02 | 9.5e-01 | -5.60e-01 | NA |
| 34 | Cbs | 7.70e-01 | 5.0e-02 | 2.60e-01 | 2.5e-01 | 2.60e-01 | 6.8e-01 | 6.50e-01 | 1.0e-02 | 8.80e-01 | 1.0e-02 | -5.50e-01 | 3.3e-01 |
| 82 | Odc1 | 1.14e+00 | 0.0e+00 | 2.20e-01 | 3.9e-01 | 2.40e-01 | 2.0e-02 | 8.00e-01 | 0.0e+00 | 2.80e-01 | 3.1e-01 | -5.40e-01 | 1.0e-02 |
| 145 | Slc25a21 | -1.30e-01 | 8.1e-01 | -1.10e-01 | 8.8e-01 | 7.80e-01 | 0.0e+00 | 1.50e-01 | 7.1e-01 | 5.40e-01 | 1.9e-01 | -5.30e-01 | 4.3e-01 |
| 70 | Mat1a | -1.80e-01 | 6.8e-01 | 2.00e-02 | 9.8e-01 | -6.00e-01 | 3.5e-01 | 1.10e+00 | 0.0e+00 | -1.50e-01 | NA | -5.20e-01 | NA |
| 69 | Kynu | -1.08e+00 | 0.0e+00 | -2.00e-02 | 9.8e-01 | -4.90e-01 | 4.1e-01 | -2.30e-01 | 1.3e-01 | 4.00e-02 | NA | -5.10e-01 | NA |
| 93 | Psat1 | 6.60e-01 | 0.0e+00 | 2.80e-01 | 5.0e-02 | 4.50e-01 | 3.0e-02 | 8.20e-01 | 0.0e+00 | 1.00e-01 | 8.0e-01 | -4.40e-01 | 2.5e-01 |
| 1 | Aadat | -7.70e-01 | 5.0e-02 | 5.60e-01 | 1.0e-02 | 8.00e-02 | 8.3e-01 | -2.00e-01 | 4.0e-01 | 7.00e-02 | 9.3e-01 | -4.30e-01 | 5.9e-01 |
| 79 | Nqo1 | 4.40e-01 | 0.0e+00 | 1.60e-01 | 6.1e-01 | 7.90e-01 | 0.0e+00 | -1.00e-02 | 9.9e-01 | 1.20e-01 | 6.6e-01 | -4.10e-01 | 1.2e-01 |
| 150 | Slc6a12 | -6.80e-01 | 1.0e-02 | -8.00e-02 | 9.2e-01 | -4.70e-01 | 4.7e-01 | 8.00e-02 | 8.2e-01 | -4.10e-01 | 5.1e-01 | -3.70e-01 | 6.4e-01 |
| 52 | Ftcd | -7.20e-01 | 7.0e-02 | 0.00e+00 | 1.0e+00 | -5.00e-01 | 4.4e-01 | 1.00e-02 | 9.9e-01 | 3.70e-01 | NA | -3.30e-01 | 6.9e-01 |
| 36 | Ckb | -2.50e-01 | 3.0e-01 | 1.70e-01 | 6.0e-01 | 9.20e-01 | 0.0e+00 | -3.40e-01 | 3.8e-01 | 2.60e-01 | 4.9e-01 | -3.10e-01 | 2.8e-01 |
| 144 | Slc25a2 | 3.20e-01 | 1.5e-01 | -6.00e-02 | 9.3e-01 | 6.70e-01 | 6.0e-02 | 2.40e-01 | 7.4e-01 | 5.00e-02 | 9.5e-01 | -2.50e-01 | 5.3e-01 |
| 74 | Mtap | -3.60e-01 | 6.0e-02 | 9.00e-02 | 8.2e-01 | -6.90e-01 | 0.0e+00 | 2.20e-01 | 1.6e-01 | -2.60e-01 | 2.6e-01 | -2.50e-01 | 2.4e-01 |
| 39 | Dars | -4.30e-01 | 1.0e-02 | 2.00e-02 | 9.8e-01 | -7.60e-01 | 1.0e-02 | -2.00e-02 | 9.7e-01 | 2.00e-01 | 5.6e-01 | -2.50e-01 | 9.0e-02 |
| 157 | Tdo2 | -3.80e-01 | 2.5e-01 | 4.00e-02 | 9.2e-01 | -4.00e-01 | 5.1e-01 | 1.81e+00 | 0.0e+00 | -1.50e-01 | NA | -2.00e-01 | NA |
| 6 | Afmid | -3.10e-01 | 2.9e-01 | 7.00e-02 | 8.7e-01 | -1.62e+00 | 0.0e+00 | 2.80e-01 | 3.6e-01 | -2.00e-01 | 7.0e-01 | -1.90e-01 | 7.9e-01 |
| 147 | Slc36a4 | 1.90e-01 | 5.7e-01 | -2.00e-02 | 9.8e-01 | 7.40e-01 | 2.0e-02 | 3.00e-02 | 9.8e-01 | 2.70e-01 | 3.4e-01 | -1.60e-01 | 6.9e-01 |
| 68 | Inmt | 5.00e-02 | 8.7e-01 | -1.00e-02 | 9.9e-01 | 9.00e-01 | 1.0e-02 | -5.00e-01 | 2.1e-01 | -2.60e-01 | 6.5e-01 | -1.50e-01 | 8.0e-01 |
| 43 | Dio2 | -6.60e-01 | 8.0e-02 | 4.60e-01 | 1.4e-01 | 1.52e+00 | 0.0e+00 | 2.20e-01 | NA | 1.00e-02 | NA | -1.30e-01 | NA |
| 142 | Slc25a13 | 4.30e-01 | 2.0e-02 | 1.00e+00 | 0.0e+00 | -2.80e-01 | 3.9e-01 | -4.00e-02 | 9.6e-01 | 1.10e+00 | 0.0e+00 | -1.10e-01 | 8.2e-01 |
| 17 | Asl | -1.10e-01 | 6.1e-01 | 3.00e-02 | 9.7e-01 | -2.10e-01 | 6.3e-01 | 1.07e+00 | 0.0e+00 | -3.00e-02 | 9.4e-01 | -9.00e-02 | 7.6e-01 |
| 51 | Fmo1 | -4.70e-01 | 0.0e+00 | 7.00e-02 | 9.1e-01 | -6.00e-01 | 0.0e+00 | 2.00e-01 | 4.3e-01 | 6.90e-01 | 0.0e+00 | -8.00e-02 | 7.4e-01 |
| 84 | Orc2 | 2.00e-01 | 4.0e-02 | 6.00e-02 | 8.8e-01 | 1.50e-01 | 3.7e-01 | 4.50e-01 | 0.0e+00 | 1.04e+00 | 0.0e+00 | -7.00e-02 | 7.6e-01 |
| 108 | Rpl10a | 3.50e-01 | 2.1e-01 | 7.50e-01 | 0.0e+00 | 2.40e-01 | 6.7e-01 | 2.30e-01 | 7.1e-01 | 4.00e-01 | 4.5e-01 | -5.00e-02 | 9.3e-01 |
| 161 | Txnrd1 | 6.60e-01 | 0.0e+00 | 1.10e-01 | 7.3e-01 | 7.50e-01 | 0.0e+00 | -2.30e-01 | 1.8e-01 | 1.10e-01 | 6.9e-01 | -4.00e-02 | 8.3e-01 |
| 158 | Th | 2.50e-01 | 6.2e-01 | 1.80e-01 | 7.6e-01 | 8.90e-01 | 0.0e+00 | 6.00e-02 | 9.6e-01 | -4.00e-02 | NA | -3.00e-02 | NA |
| 8 | Agxt2 | -3.40e-01 | NA | 1.00e-02 | NA | -9.30e-01 | 0.0e+00 | 5.00e-02 | 9.3e-01 | 5.00e-02 | NA | -3.00e-02 | NA |
| 20 | Aspg | -4.90e-01 | 1.4e-01 | -2.10e-01 | 7.3e-01 | -4.20e-01 | 5.6e-01 | 6.40e-01 | 0.0e+00 | 1.10e-01 | NA | -3.00e-02 | NA |
| 26 | Bbox1 | -9.60e-01 | 1.0e-02 | 1.10e-01 | 8.2e-01 | -6.20e-01 | 3.3e-01 | 3.20e-01 | 9.0e-02 | 7.00e-02 | NA | -2.00e-02 | NA |
| 30 | Bhmt | -4.00e-01 | 2.8e-01 | 6.00e-02 | 9.1e-01 | -6.00e-01 | 3.2e-01 | 1.19e+00 | 0.0e+00 | -2.70e-01 | 5.2e-01 | -1.00e-02 | NA |
| 140 | Slc25a10 | 6.40e-01 | 0.0e+00 | 1.30e-01 | 7.3e-01 | -4.50e-01 | 8.0e-02 | 3.40e-01 | 3.2e-01 | 2.00e-02 | 9.7e-01 | 0.00e+00 | 1.0e+00 |
| 62 | Hibch | -5.40e-01 | 0.0e+00 | 1.80e-01 | 4.9e-01 | -6.40e-01 | 0.0e+00 | 5.00e-02 | 8.4e-01 | -1.40e-01 | 6.9e-01 | 7.00e-02 | 6.4e-01 |
| 154 | Srr | 1.40e-01 | 5.1e-01 | 2.00e-02 | 9.7e-01 | 1.50e-01 | 6.9e-01 | 1.60e-01 | 6.6e-01 | 5.90e-01 | 0.0e+00 | 1.00e-01 | 7.6e-01 |
| 135 | Sat1 | 9.60e-01 | 0.0e+00 | 2.40e-01 | 5.0e-01 | 5.60e-01 | 4.0e-02 | 1.50e-01 | 7.3e-01 | 6.50e-01 | 5.0e-02 | 1.10e-01 | 7.0e-01 |
| 134 | Sardh | 2.00e-01 | 9.0e-02 | 1.60e-01 | 7.0e-01 | -2.50e-01 | 2.9e-01 | 8.30e-01 | 0.0e+00 | 4.00e-02 | 9.2e-01 | 1.20e-01 | 6.5e-01 |
| 40 | Dbt | 3.80e-01 | 0.0e+00 | 2.30e-01 | 3.2e-01 | 8.00e-02 | 7.9e-01 | 1.08e+00 | 0.0e+00 | 8.70e-01 | 0.0e+00 | 1.50e-01 | 4.4e-01 |
| 156 | Tat | -3.80e-01 | 3.2e-01 | 4.00e-02 | 9.4e-01 | -3.80e-01 | 5.5e-01 | 1.63e+00 | 0.0e+00 | -2.60e-01 | NA | 1.50e-01 | NA |
| 148 | Slc3a2 | 3.60e-01 | 0.0e+00 | 1.70e-01 | 5.7e-01 | 8.50e-01 | 0.0e+00 | 8.10e-01 | 0.0e+00 | 9.60e-01 | 0.0e+00 | 1.90e-01 | 3.5e-01 |
| 136 | Scly | -2.00e-02 | 9.6e-01 | -3.00e-02 | 9.7e-01 | -9.50e-01 | 0.0e+00 | -1.10e-01 | 8.1e-01 | 1.00e-02 | 9.7e-01 | 2.20e-01 | 2.6e-01 |
| 138 | Sephs2 | -1.10e-01 | 5.9e-01 | 2.70e-01 | 2.8e-01 | 7.70e-01 | 0.0e+00 | 1.16e+00 | 0.0e+00 | 2.80e-01 | 2.1e-01 | 2.40e-01 | 1.8e-01 |
| 86 | Pdha1 | 6.70e-01 | 0.0e+00 | 1.10e-01 | 6.3e-01 | 3.10e-01 | 1.0e-02 | 1.50e-01 | 4.9e-01 | 2.40e-01 | 5.7e-01 | 2.70e-01 | 4.0e-02 |
| 9 | Ahcy | 2.40e-01 | 1.0e-01 | 2.20e-01 | 5.4e-01 | 5.90e-01 | 2.0e-02 | 5.70e-01 | 1.0e-02 | 1.80e-01 | 3.5e-01 | 2.70e-01 | 1.0e-01 |
| 102 | Psmd8 | 2.40e-01 | 7.0e-02 | 1.60e-01 | 5.4e-01 | 1.90e-01 | 2.5e-01 | 1.50e-01 | 4.8e-01 | 8.20e-01 | 0.0e+00 | 3.20e-01 | 2.1e-01 |
| 71 | Mccc2 | 6.50e-01 | 0.0e+00 | 4.80e-01 | 0.0e+00 | -1.00e-01 | 7.1e-01 | 1.70e-01 | 5.7e-01 | 2.40e-01 | 1.0e-01 | 3.30e-01 | 1.1e-01 |
| 45 | Dlat | -2.50e-01 | 1.4e-01 | -1.10e-01 | 8.1e-01 | 6.00e-02 | 7.7e-01 | 6.10e-01 | 0.0e+00 | 1.90e-01 | 6.4e-01 | 3.30e-01 | 1.0e-02 |
| 75 | Mtrr | -1.30e-01 | 3.8e-01 | -3.00e-01 | 8.0e-02 | -6.90e-01 | 0.0e+00 | -6.00e-02 | 8.7e-01 | -4.00e-02 | 9.1e-01 | 3.70e-01 | 0.0e+00 |
| 16 | Arg2 | 6.10e-01 | 3.0e-02 | 1.80e-01 | 6.2e-01 | 4.30e-01 | 3.1e-01 | 1.20e-01 | 9.2e-01 | 1.40e-01 | 8.0e-01 | 3.70e-01 | 2.3e-01 |
| 22 | Ass1 | -1.60e-01 | 6.9e-01 | 2.20e-01 | 7.0e-01 | 5.80e-01 | 1.1e-01 | 6.90e-01 | 1.0e-02 | 1.60e-01 | 8.4e-01 | 3.80e-01 | 5.8e-01 |
| 133 | Rrp1 | 1.00e-01 | 6.9e-01 | 2.40e-01 | 4.9e-01 | 1.15e+00 | 0.0e+00 | 4.40e-01 | 1.2e-01 | 8.00e-02 | 8.7e-01 | 3.80e-01 | 2.0e-02 |
| 123 | Rpl9 | 4.20e-01 | 1.3e-01 | 1.50e-01 | 8.0e-01 | 6.00e-01 | 2.0e-02 | -4.10e-01 | 2.9e-01 | 7.00e-01 | 1.0e-02 | 4.30e-01 | 1.4e-01 |
| 151 | Slc7a5 | 8.90e-01 | 0.0e+00 | 1.50e-01 | 4.8e-01 | 6.20e-01 | 0.0e+00 | -8.00e-01 | 0.0e+00 | 2.04e+00 | 0.0e+00 | 4.40e-01 | 2.4e-01 |
| 32 | Carnmt1 | -1.60e-01 | 6.6e-01 | -9.00e-02 | 8.9e-01 | 8.50e-01 | 7.0e-02 | -2.50e-01 | 6.9e-01 | -2.80e-01 | 5.7e-01 | 4.40e-01 | 6.0e-02 |
| 48 | Eprs | -1.00e-02 | 9.7e-01 | 4.00e-02 | 9.3e-01 | 9.20e-01 | 0.0e+00 | 3.60e-01 | 1.7e-01 | 5.60e-01 | 0.0e+00 | 4.50e-01 | 0.0e+00 |
| 83 | Orc1 | 1.80e-01 | 7.1e-01 | 5.00e-02 | 9.5e-01 | 2.30e-01 | 7.4e-01 | 1.26e+00 | 1.0e-02 | -4.70e-01 | 4.2e-01 | 4.70e-01 | 5.2e-01 |
| 129 | Rps18 | 4.60e-01 | 3.0e-02 | 3.00e-01 | 2.9e-01 | 6.30e-01 | 0.0e+00 | 7.70e-01 | 0.0e+00 | 5.90e-01 | 1.0e-02 | 4.80e-01 | 3.0e-02 |
| 57 | Got1 | 1.40e-01 | 6.3e-01 | 8.00e-02 | 7.6e-01 | 5.80e-01 | 0.0e+00 | 2.42e+00 | 0.0e+00 | -5.50e-01 | 1.4e-01 | 4.90e-01 | 3.0e-02 |
| 33 | Carns1 | -7.70e-01 | 1.0e-02 | 5.00e-02 | 9.2e-01 | -1.03e+00 | 0.0e+00 | -6.00e-02 | 9.6e-01 | -5.70e-01 | 1.7e-01 | 5.00e-01 | 4.0e-02 |
| 24 | Azin1 | -2.40e-01 | 5.0e-02 | 5.00e-01 | 0.0e+00 | 5.40e-01 | 1.1e-01 | 7.80e-01 | 0.0e+00 | 3.70e-01 | 1.9e-01 | 5.30e-01 | 5.0e-02 |
| 41 | Ddo | -1.09e+00 | 0.0e+00 | 2.20e-01 | 5.7e-01 | 2.50e-01 | 7.5e-01 | -2.00e-02 | 9.9e-01 | -2.00e-02 | 9.8e-01 | 5.70e-01 | 9.0e-02 |
| 12 | Aldh9a1 | 1.90e-01 | 4.0e-02 | 5.00e-02 | 8.9e-01 | -2.00e-02 | 9.7e-01 | 3.60e-01 | 9.0e-02 | 7.90e-01 | 0.0e+00 | 5.90e-01 | 0.0e+00 |
| 96 | Psmb1 | 3.40e-01 | 3.0e-02 | 2.40e-01 | 4.0e-01 | 2.00e-01 | 5.3e-01 | 1.00e-01 | 8.7e-01 | 4.10e-01 | 8.0e-02 | 6.10e-01 | 4.0e-02 |
| 28 | Bcat2 | 1.90e-01 | 2.8e-01 | -1.90e-01 | 7.4e-01 | -1.70e-01 | 3.8e-01 | 5.00e-02 | 9.6e-01 | -1.80e-01 | 5.5e-01 | 6.20e-01 | 0.0e+00 |
| 105 | Rida | -2.70e-01 | 3.3e-01 | 3.00e-01 | 3.9e-01 | -9.00e-02 | 7.0e-01 | -3.30e-01 | 1.1e-01 | 2.00e-01 | 6.4e-01 | 6.20e-01 | 2.0e-02 |
| 122 | Rpl8 | 1.50e-01 | 4.9e-01 | 3.60e-01 | 1.7e-01 | 9.00e-02 | 8.6e-01 | -7.00e-02 | 9.2e-01 | -5.00e-02 | 9.5e-01 | 6.20e-01 | 2.0e-02 |
| 109 | Rpl14 | 4.00e-02 | 8.9e-01 | 2.30e-01 | 5.3e-01 | 2.50e-01 | 4.7e-01 | -3.00e-02 | 9.8e-01 | 0.00e+00 | 1.0e+00 | 6.30e-01 | 2.0e-02 |
| 99 | Psmc1 | 4.60e-01 | 0.0e+00 | 3.10e-01 | 2.0e-01 | 3.90e-01 | 2.5e-01 | 2.40e-01 | 5.0e-01 | 2.90e-01 | 2.8e-01 | 6.40e-01 | 0.0e+00 |
| 97 | Psmb5 | 5.00e-02 | 8.7e-01 | 2.00e-01 | 5.3e-01 | 5.00e-02 | 8.6e-01 | 2.00e-02 | 9.7e-01 | 1.40e-01 | 7.3e-01 | 6.70e-01 | 1.0e-02 |
| 4 | Adi1 | -2.20e-01 | 1.4e-01 | 1.70e-01 | 5.7e-01 | 5.00e-02 | 9.1e-01 | -2.00e-02 | 9.7e-01 | 1.00e-02 | 9.8e-01 | 6.70e-01 | 0.0e+00 |
| 44 | Dio3 | 6.80e-01 | 1.0e-01 | 3.30e-01 | NA | 8.20e-01 | 1.5e-01 | 1.07e+00 | 2.0e-02 | 1.10e-01 | NA | 6.70e-01 | 3.3e-01 |
| 101 | Psmd13 | 3.20e-01 | 5.0e-02 | 2.90e-01 | 2.9e-01 | 3.70e-01 | 2.6e-01 | 2.10e-01 | 6.2e-01 | 3.00e-01 | 2.5e-01 | 6.80e-01 | 0.0e+00 |
| 155 | Suox | -1.70e-01 | 3.8e-01 | -1.10e-01 | 7.9e-01 | -2.30e-01 | 2.2e-01 | 1.30e-01 | 6.6e-01 | -2.40e-01 | 2.2e-01 | 6.90e-01 | 0.0e+00 |
| 67 | Il4i1 | -3.20e-01 | 3.1e-01 | -1.00e-02 | 9.9e-01 | 3.60e-01 | 3.3e-01 | 3.70e-01 | 4.8e-01 | 2.00e-01 | 7.1e-01 | 6.90e-01 | 5.0e-02 |
| 94 | Psma4 | -1.00e-02 | 9.7e-01 | 2.60e-01 | 2.6e-01 | -1.60e-01 | 6.7e-01 | 3.00e-02 | 9.6e-01 | 2.60e-01 | 3.7e-01 | 7.00e-01 | 0.0e+00 |
| 113 | Rpl23 | 2.00e-01 | 3.3e-01 | 4.80e-01 | 1.3e-01 | 3.90e-01 | 3.0e-01 | -8.00e-02 | 9.2e-01 | 3.00e-01 | 5.6e-01 | 7.10e-01 | 0.0e+00 |
| 130 | Rps2 | 3.50e-01 | 1.7e-01 | 4.30e-01 | 1.9e-01 | 3.90e-01 | 5.2e-01 | -6.00e-02 | 9.6e-01 | -1.00e-02 | 9.9e-01 | 7.20e-01 | 2.0e-02 |
| 104 | Pycrl | -1.50e-01 | 5.8e-01 | 2.00e-01 | 4.8e-01 | -4.40e-01 | 1.3e-01 | 2.40e-01 | 5.9e-01 | -2.00e-02 | 9.8e-01 | 7.20e-01 | 2.0e-02 |
| 14 | Apip | -2.90e-01 | 2.0e-01 | -1.00e-02 | 9.8e-01 | -4.90e-01 | 3.0e-02 | 2.00e-02 | 9.9e-01 | -1.70e-01 | 5.8e-01 | 7.30e-01 | 0.0e+00 |
| 111 | Rpl18 | 1.60e-01 | 5.7e-01 | 4.60e-01 | 8.0e-02 | 1.10e-01 | 8.4e-01 | 1.00e-02 | 9.9e-01 | 2.90e-01 | 6.1e-01 | 7.40e-01 | 2.0e-02 |
| 131 | Rps24 | 1.90e-01 | 5.0e-01 | 3.20e-01 | 4.0e-01 | 1.70e-01 | 7.1e-01 | 8.00e-02 | 9.4e-01 | 1.10e-01 | 8.8e-01 | 7.50e-01 | 0.0e+00 |
| 5 | Ado | 1.00e-02 | 9.8e-01 | -9.00e-02 | 9.1e-01 | 2.60e-01 | 7.0e-01 | 3.90e-01 | 5.1e-01 | -1.10e-01 | 8.8e-01 | 7.80e-01 | 7.0e-02 |
| 29 | Bckdha | 2.90e-01 | 1.6e-01 | 4.30e-01 | 8.0e-02 | -9.00e-02 | 7.8e-01 | 1.00e-01 | 7.9e-01 | 1.20e-01 | 8.1e-01 | 7.80e-01 | 0.0e+00 |
| 87 | Pdhx | 6.00e-02 | 7.8e-01 | 1.70e-01 | 5.1e-01 | 1.00e-01 | 7.8e-01 | 3.70e-01 | 1.0e-01 | -1.00e-02 | 9.8e-01 | 7.90e-01 | 0.0e+00 |
| 120 | Rpl3l | -1.70e-01 | NA | -8.00e-02 | NA | 1.30e-01 | NA | 0.00e+00 | NA | -3.90e-01 | 3.5e-01 | 8.00e-01 | 0.0e+00 |
| 73 | Mri1 | -6.00e-02 | 8.7e-01 | 2.60e-01 | 4.1e-01 | -1.03e+00 | 0.0e+00 | -1.80e-01 | 7.6e-01 | -4.00e-01 | 2.9e-01 | 8.00e-01 | 0.0e+00 |
| 66 | Iars | 2.70e-01 | 1.0e-02 | 3.00e-02 | 9.5e-01 | 6.90e-01 | 0.0e+00 | 3.90e-01 | 1.1e-01 | 3.20e-01 | 2.5e-01 | 8.10e-01 | 0.0e+00 |
| 53 | Gamt | -5.40e-01 | 2.0e-02 | 5.00e-02 | 9.2e-01 | -2.10e-01 | 6.0e-01 | -1.90e-01 | 6.9e-01 | -5.00e-02 | 9.3e-01 | 8.10e-01 | 0.0e+00 |
| 50 | Fau | 2.00e-01 | 5.1e-01 | 5.60e-01 | 7.0e-02 | 1.70e-01 | 7.9e-01 | 0.00e+00 | 1.0e+00 | 2.70e-01 | 6.6e-01 | 8.30e-01 | 1.0e-02 |
| 115 | Rpl35 | 2.50e-01 | 3.0e-01 | 5.00e-01 | 1.1e-01 | 3.00e-02 | 9.6e-01 | -6.00e-02 | 9.5e-01 | 1.40e-01 | 8.5e-01 | 8.40e-01 | 1.0e-02 |
| 77 | Ndufab1 | -9.00e-02 | 7.2e-01 | 3.80e-01 | 1.7e-01 | 4.00e-02 | 9.3e-01 | 9.00e-02 | 9.2e-01 | 4.00e-02 | 9.5e-01 | 8.40e-01 | 0.0e+00 |
| 80 | Oaz1 | 1.70e-01 | 3.7e-01 | 1.40e-01 | 7.0e-01 | 5.90e-01 | 0.0e+00 | -9.00e-02 | 8.4e-01 | 1.60e-01 | 6.3e-01 | 8.40e-01 | 0.0e+00 |
| 100 | Psmc5 | 2.60e-01 | 1.4e-01 | 2.70e-01 | 3.9e-01 | 1.80e-01 | 7.1e-01 | 3.70e-01 | 2.8e-01 | 2.20e-01 | 5.6e-01 | 8.50e-01 | 0.0e+00 |
| 132 | Rps3 | 2.90e-01 | 2.2e-01 | 5.50e-01 | 6.0e-02 | 1.20e-01 | 8.5e-01 | -9.00e-02 | 9.3e-01 | -6.00e-02 | 9.4e-01 | 8.50e-01 | 0.0e+00 |
| 141 | Slc25a12 | 2.20e-01 | 1.2e-01 | 3.00e-02 | 9.6e-01 | -6.20e-01 | 0.0e+00 | 4.00e-01 | 9.0e-02 | -4.90e-01 | 2.6e-01 | 8.80e-01 | 0.0e+00 |
| 21 | Asrgl1 | -7.00e-02 | 8.5e-01 | 3.00e-02 | 9.4e-01 | -4.00e-01 | 1.8e-01 | -3.50e-01 | 2.4e-01 | -1.80e-01 | 6.0e-01 | 8.80e-01 | 0.0e+00 |
| 114 | Rpl28 | 2.20e-01 | 3.7e-01 | 5.60e-01 | 0.0e+00 | 7.00e-02 | 8.9e-01 | -9.00e-02 | 9.2e-01 | 3.00e-02 | 9.8e-01 | 8.80e-01 | 1.0e-02 |
| 125 | Rps11 | 1.30e-01 | 6.5e-01 | 4.20e-01 | 1.7e-01 | 3.00e-02 | 9.6e-01 | -5.00e-02 | 9.6e-01 | 9.00e-02 | 9.0e-01 | 8.80e-01 | 0.0e+00 |
| 118 | Rpl37a | 1.70e-01 | 5.7e-01 | 3.90e-01 | 1.5e-01 | 2.00e-01 | 6.4e-01 | 8.00e-02 | 9.4e-01 | 4.00e-02 | 9.6e-01 | 9.00e-01 | 0.0e+00 |
| 119 | Rpl38 | 2.00e-02 | 9.7e-01 | 5.20e-01 | 1.5e-01 | -1.10e-01 | 8.9e-01 | -2.00e-02 | 9.8e-01 | 1.00e-01 | 9.0e-01 | 9.00e-01 | 1.0e-02 |
| 95 | Psma6 | 5.80e-01 | 0.0e+00 | 5.30e-01 | 0.0e+00 | -7.00e-02 | 9.0e-01 | 2.60e-01 | 5.7e-01 | 5.20e-01 | 8.0e-02 | 9.10e-01 | 0.0e+00 |
| 81 | Oaz2 | -4.40e-01 | 1.0e-02 | 1.60e-01 | 5.5e-01 | 1.10e-01 | 7.2e-01 | -5.40e-01 | 1.0e-02 | -1.90e-01 | 6.0e-01 | 9.10e-01 | 0.0e+00 |
| 128 | Rps16 | 4.00e-02 | 9.2e-01 | 4.90e-01 | 5.0e-02 | 1.00e-01 | 8.8e-01 | -8.00e-02 | 9.4e-01 | -3.00e-02 | 9.7e-01 | 9.20e-01 | 0.0e+00 |
| 112 | Rpl22 | 1.90e-01 | 5.2e-01 | 3.80e-01 | 3.2e-01 | 1.30e-01 | 8.3e-01 | 4.00e-02 | 9.7e-01 | 2.50e-01 | 6.7e-01 | 9.30e-01 | 0.0e+00 |
| 25 | Azin2 | 2.20e-01 | 5.4e-01 | 9.00e-02 | 8.8e-01 | 3.00e-01 | 4.1e-01 | 9.10e-01 | 2.0e-02 | -5.50e-01 | 1.2e-01 | 9.40e-01 | 7.0e-02 |
| 13 | Amd1 | 5.00e-02 | 8.0e-01 | -1.80e-01 | 6.0e-01 | -9.50e-01 | 0.0e+00 | 1.66e+00 | 0.0e+00 | 6.60e-01 | 0.0e+00 | 9.40e-01 | 0.0e+00 |
| 49 | Ethe1 | 1.90e-01 | 3.0e-01 | 1.00e-01 | 8.6e-01 | -1.50e-01 | 7.6e-01 | 9.20e-01 | 0.0e+00 | 2.10e-01 | 6.8e-01 | 9.80e-01 | 0.0e+00 |
| 63 | Hoga1 | -5.00e-02 | 8.9e-01 | 1.30e-01 | 8.2e-01 | -3.50e-01 | 2.3e-01 | 2.50e-01 | 3.4e-01 | 6.70e-01 | 4.0e-02 | 1.03e+00 | 0.0e+00 |
| 124 | Rplp2 | 8.00e-02 | 8.8e-01 | 2.50e-01 | 6.5e-01 | 5.50e-01 | 2.8e-01 | -1.00e-02 | 1.0e+00 | 1.80e-01 | 8.2e-01 | 1.03e+00 | 2.0e-02 |
| 110 | Rpl17 | 8.00e-02 | 8.5e-01 | 5.80e-01 | 6.0e-02 | -3.00e-02 | 9.6e-01 | -2.00e-02 | 9.9e-01 | 8.00e-02 | 9.2e-01 | 1.04e+00 | 0.0e+00 |
| 37 | Ckm | -1.70e-01 | 4.6e-01 | 1.00e-02 | NA | 2.00e-01 | NA | -1.00e-01 | NA | -4.90e-01 | 1.9e-01 | 1.06e+00 | 0.0e+00 |
| 3 | Acad8 | -1.70e-01 | 5.5e-01 | 3.00e-02 | 9.6e-01 | -2.40e-01 | 4.9e-01 | 4.00e-02 | 9.6e-01 | -1.10e-01 | 7.9e-01 | 1.09e+00 | 0.0e+00 |
| 127 | Rps15a | 1.30e-01 | 7.7e-01 | 4.10e-01 | 3.1e-01 | -1.80e-01 | 6.7e-01 | -6.00e-02 | 9.6e-01 | 1.00e-01 | 9.0e-01 | 1.09e+00 | 0.0e+00 |
| 146 | Slc25a44 | 4.00e-01 | 8.0e-02 | -7.00e-02 | 9.0e-01 | 4.80e-01 | 1.5e-01 | 3.20e-01 | 3.5e-01 | -3.60e-01 | 2.9e-01 | 1.11e+00 | 0.0e+00 |
| 103 | Psmd9 | 6.10e-01 | 1.0e-02 | 3.90e-01 | 2.9e-01 | 3.30e-01 | 4.6e-01 | 7.30e-01 | 5.0e-02 | 3.70e-01 | 3.2e-01 | 1.11e+00 | 0.0e+00 |
| 72 | Mpst | 1.30e-01 | 6.1e-01 | 3.90e-01 | 2.3e-01 | -1.80e-01 | 7.4e-01 | -1.40e-01 | 8.2e-01 | 0.00e+00 | 1.0e+00 | 1.12e+00 | 0.0e+00 |
| 117 | Rpl37 | 8.00e-02 | 8.6e-01 | 5.00e-01 | 1.5e-01 | -8.00e-02 | 9.0e-01 | -2.00e-02 | 9.9e-01 | 1.60e-01 | 8.4e-01 | 1.13e+00 | 0.0e+00 |
| 116 | Rpl36 | 2.60e-01 | 4.9e-01 | 5.10e-01 | 1.7e-01 | 2.00e-02 | 9.8e-01 | 1.80e-01 | 8.2e-01 | 4.30e-01 | 4.5e-01 | 1.13e+00 | 0.0e+00 |
| 139 | Shmt1 | -6.00e-02 | 7.7e-01 | 4.10e-01 | 2.5e-01 | -6.10e-01 | 3.0e-02 | -1.70e-01 | 6.0e-01 | -4.00e-02 | 9.4e-01 | 1.20e+00 | 0.0e+00 |
| 153 | Smox | 2.50e-01 | 2.4e-01 | 3.80e-01 | 7.0e-02 | 5.20e-01 | 2.0e-02 | 9.10e-01 | 0.0e+00 | -1.10e-01 | 8.6e-01 | 1.20e+00 | 0.0e+00 |
| 23 | Auh | 1.40e-01 | 6.3e-01 | 2.30e-01 | 4.7e-01 | 3.20e-01 | 3.4e-01 | 3.30e-01 | 3.3e-01 | 1.50e-01 | 7.3e-01 | 1.21e+00 | 0.0e+00 |
| 59 | Grhpr | 2.80e-01 | 1.2e-01 | 2.70e-01 | 4.8e-01 | -2.50e-01 | 5.9e-01 | -3.00e-01 | 5.1e-01 | -5.30e-01 | 1.0e-01 | 1.22e+00 | 0.0e+00 |
| 160 | Tst | 3.10e-01 | 7.0e-02 | 2.20e-01 | 4.3e-01 | -2.90e-01 | 2.8e-01 | 0.00e+00 | 1.0e+00 | 4.00e-02 | 9.6e-01 | 1.28e+00 | 0.0e+00 |
| 126 | Rps15 | 0.00e+00 | 1.0e+00 | 5.40e-01 | 1.1e-01 | -1.80e-01 | 7.9e-01 | -1.70e-01 | 8.3e-01 | 1.10e-01 | 9.1e-01 | 1.33e+00 | 0.0e+00 |
| 121 | Rpl6 | 5.20e-01 | 4.0e-02 | 6.10e-01 | 8.0e-02 | -1.80e-01 | 7.9e-01 | 1.00e-01 | 9.2e-01 | -1.00e-01 | 9.1e-01 | 1.34e+00 | 0.0e+00 |
| 55 | Glul | 1.34e+00 | 0.0e+00 | 2.10e-01 | 3.5e-01 | 5.00e-02 | 8.9e-01 | 1.10e-01 | 7.6e-01 | 8.40e-01 | 0.0e+00 | 1.38e+00 | 0.0e+00 |
| 98 | Psmb6 | 4.50e-01 | 1.4e-01 | 4.00e-01 | 3.2e-01 | -2.70e-01 | 6.6e-01 | 8.00e-02 | 9.5e-01 | -1.00e-01 | 9.1e-01 | 1.52e+00 | 0.0e+00 |
| 58 | Gpt2 | -2.20e-01 | 5.9e-01 | 3.40e-01 | 2.0e-02 | -2.70e-01 | 2.4e-01 | 5.20e-01 | 2.0e-02 | 1.04e+00 | 0.0e+00 | 1.65e+00 | 0.0e+00 |
| 91 | Pnmt | 3.10e-01 | 5.3e-01 | 5.00e-02 | NA | 2.80e-01 | 5.7e-01 | 1.10e-01 | NA | 5.00e-02 | NA | 1.85e+00 | 0.0e+00 |
| 19 | Aspa | 1.34e+00 | 0.0e+00 | 1.24e+00 | 0.0e+00 | 4.10e-01 | 2.8e-01 | 2.17e+00 | 0.0e+00 | 1.72e+00 | 0.0e+00 | 2.65e+00 | 0.0e+00 |
| 7 | Agxt | -3.20e-01 | 5.0e-01 | 6.00e-02 | 9.1e-01 | -4.60e-01 | 5.0e-01 | 6.20e-01 | 3.0e-02 | -5.00e-02 | NA | NA | NA |
| 31 | Bhmt2 | -7.10e-01 | 5.0e-02 | 3.00e-02 | 9.5e-01 | -4.80e-01 | 4.6e-01 | 6.00e-02 | 8.7e-01 | -6.00e-02 | NA | NA | NA |
| 56 | Gnmt | -2.40e-01 | 5.6e-01 | -1.00e-02 | NA | -3.00e-02 | NA | 1.05e+00 | 0.0e+00 | NA | NA | NA | NA |
AAMet %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S15. Relative changes in the expression of genes involved in amino acid metabolism after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))Polyamine%>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>%kable(caption = "Supplementary Table 14. Relative changes in the expression of genes involved in polyamine metabolism after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(Polyamine$Adrenal_padj),F,ifelse(Polyamine$Adrenal_padj<.1,T,F)),color= ifelse(is.na(Polyamine$Adrenal_padj),"gray",ifelse(Polyamine$Adrenal_padj<.1,spec_color(Polyamine$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(Polyamine$HT_padj),F,ifelse(Polyamine$HT_padj<.1,T,F)),color= ifelse(is.na(Polyamine$HT_padj),"gray",ifelse(Polyamine$HT_padj<.1,spec_color(Polyamine$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(Polyamine$Liver_padj),F,ifelse(Polyamine$Liver_padj<.1,T,F)),color= ifelse(is.na(Polyamine$Liver_padj),"gray",ifelse(Polyamine$Liver_padj<.1,spec_color(Polyamine$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(Polyamine$Lung_padj),F,ifelse(Polyamine$Lung_padj<.1,T,F)),color= ifelse(is.na(Polyamine$Lung_padj),"gray",ifelse(Polyamine$Lung_padj <.1,spec_color(Polyamine$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(Polyamine$Adipose_padj),F,ifelse(Polyamine$Adipose_padj<.1,T,F)),color= ifelse(is.na(Polyamine$Adipose_padj),"gray",ifelse(Polyamine$Adipose_padj<.1, spec_color(Polyamine$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(Polyamine$Muscle_padj),F,ifelse(Polyamine$Muscle_padj<.1,T,F)),color= ifelse(is.na(Polyamine$Muscle_padj),"gray",ifelse(Polyamine$Muscle_padj<.1,spec_color(Polyamine$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 19 | Smo | -7.10e-01 | 0.0e+00 | -6.0e-02 | 9.1e-01 | -5.1e-01 | 1.0e-02 | -3.80e-01 | 2.0e-01 | -4.4e-01 | 9.0e-02 | -7.30e-01 | 0.0e+00 |
| 7 | Odc1 | 1.14e+00 | 0.0e+00 | 2.2e-01 | 3.9e-01 | 2.4e-01 | 2.0e-02 | 8.00e-01 | 0.0e+00 | 2.8e-01 | 3.1e-01 | -5.40e-01 | 1.0e-02 |
| 4 | Nqo1 | 4.40e-01 | 0.0e+00 | 1.6e-01 | 6.1e-01 | 7.9e-01 | 0.0e+00 | -1.00e-02 | 9.9e-01 | 1.2e-01 | 6.6e-01 | -4.10e-01 | 1.2e-01 |
| 18 | Sat1 | 9.60e-01 | 0.0e+00 | 2.4e-01 | 5.0e-01 | 5.6e-01 | 4.0e-02 | 1.50e-01 | 7.3e-01 | 6.5e-01 | 5.0e-02 | 1.10e-01 | 7.0e-01 |
| 16 | Psmd8 | 2.40e-01 | 7.0e-02 | 1.6e-01 | 5.4e-01 | 1.9e-01 | 2.5e-01 | 1.50e-01 | 4.8e-01 | 8.2e-01 | 0.0e+00 | 3.20e-01 | 2.1e-01 |
| 2 | Azin1 | -2.40e-01 | 5.0e-02 | 5.0e-01 | 0.0e+00 | 5.4e-01 | 1.1e-01 | 7.80e-01 | 0.0e+00 | 3.7e-01 | 1.9e-01 | 5.30e-01 | 5.0e-02 |
| 10 | Psmb1 | 3.40e-01 | 3.0e-02 | 2.4e-01 | 4.0e-01 | 2.0e-01 | 5.3e-01 | 1.00e-01 | 8.7e-01 | 4.1e-01 | 8.0e-02 | 6.10e-01 | 4.0e-02 |
| 13 | Psmc1 | 4.60e-01 | 0.0e+00 | 3.1e-01 | 2.0e-01 | 3.9e-01 | 2.5e-01 | 2.40e-01 | 5.0e-01 | 2.9e-01 | 2.8e-01 | 6.40e-01 | 0.0e+00 |
| 11 | Psmb5 | 5.00e-02 | 8.7e-01 | 2.0e-01 | 5.3e-01 | 5.0e-02 | 8.6e-01 | 2.00e-02 | 9.7e-01 | 1.4e-01 | 7.3e-01 | 6.70e-01 | 1.0e-02 |
| 15 | Psmd13 | 3.20e-01 | 5.0e-02 | 2.9e-01 | 2.9e-01 | 3.7e-01 | 2.6e-01 | 2.10e-01 | 6.2e-01 | 3.0e-01 | 2.5e-01 | 6.80e-01 | 0.0e+00 |
| 8 | Psma4 | -1.00e-02 | 9.7e-01 | 2.6e-01 | 2.6e-01 | -1.6e-01 | 6.7e-01 | 3.00e-02 | 9.6e-01 | 2.6e-01 | 3.7e-01 | 7.00e-01 | 0.0e+00 |
| 5 | Oaz1 | 1.70e-01 | 3.7e-01 | 1.4e-01 | 7.0e-01 | 5.9e-01 | 0.0e+00 | -9.00e-02 | 8.4e-01 | 1.6e-01 | 6.3e-01 | 8.40e-01 | 0.0e+00 |
| 14 | Psmc5 | 2.60e-01 | 1.4e-01 | 2.7e-01 | 3.9e-01 | 1.8e-01 | 7.1e-01 | 3.70e-01 | 2.8e-01 | 2.2e-01 | 5.6e-01 | 8.50e-01 | 0.0e+00 |
| 9 | Psma6 | 5.80e-01 | 0.0e+00 | 5.3e-01 | 0.0e+00 | -7.0e-02 | 9.0e-01 | 2.60e-01 | 5.7e-01 | 5.2e-01 | 8.0e-02 | 9.10e-01 | 0.0e+00 |
| 6 | Oaz2 | -4.40e-01 | 1.0e-02 | 1.6e-01 | 5.5e-01 | 1.1e-01 | 7.2e-01 | -5.40e-01 | 1.0e-02 | -1.9e-01 | 6.0e-01 | 9.10e-01 | 0.0e+00 |
| 3 | Azin2 | 2.20e-01 | 5.4e-01 | 9.0e-02 | 8.8e-01 | 3.0e-01 | 4.1e-01 | 9.10e-01 | 2.0e-02 | -5.5e-01 | 1.2e-01 | 9.40e-01 | 7.0e-02 |
| 1 | Amd1 | 5.00e-02 | 8.0e-01 | -1.8e-01 | 6.0e-01 | -9.5e-01 | 0.0e+00 | 1.66e+00 | 0.0e+00 | 6.6e-01 | 0.0e+00 | 9.40e-01 | 0.0e+00 |
| 17 | Psmd9 | 6.10e-01 | 1.0e-02 | 3.9e-01 | 2.9e-01 | 3.3e-01 | 4.6e-01 | 7.30e-01 | 5.0e-02 | 3.7e-01 | 3.2e-01 | 1.11e+00 | 0.0e+00 |
| 20 | Smox | 2.50e-01 | 2.4e-01 | 3.8e-01 | 7.0e-02 | 5.2e-01 | 2.0e-02 | 9.10e-01 | 0.0e+00 | -1.1e-01 | 8.6e-01 | 1.20e+00 | 0.0e+00 |
| 12 | Psmb6 | 4.50e-01 | 1.4e-01 | 4.0e-01 | 3.2e-01 | -2.7e-01 | 6.6e-01 | 8.00e-02 | 9.5e-01 | -1.0e-01 | 9.1e-01 | 1.52e+00 | 0.0e+00 |
Polyamine %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S16. Relative changes in the expression of genes involved in polyamine metabolism after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))GPCR%>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>%kable(caption = "Supplementary Table 17. Relative changes in the expression of genes involved in GPCR signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(GPCR$Adrenal_padj),F,ifelse(GPCR$Adrenal_padj<.1,T,F)),color= ifelse(is.na(GPCR$Adrenal_padj),"gray",ifelse(GPCR$Adrenal_padj<.1,spec_color(GPCR$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(GPCR$HT_padj),F,ifelse(GPCR$HT_padj<.1,T,F)),color= ifelse(is.na(GPCR$HT_padj),"gray",ifelse(GPCR$HT_padj<.1,spec_color(GPCR$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(GPCR$Liver_padj),F,ifelse(GPCR$Liver_padj<.1,T,F)),color= ifelse(is.na(GPCR$Liver_padj),"gray",ifelse(GPCR$Liver_padj<.1,spec_color(GPCR$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(GPCR$Lung_padj),F,ifelse(GPCR$Lung_padj<.1,T,F)),color= ifelse(is.na(GPCR$Lung_padj),"gray",ifelse(GPCR$Lung_padj <.1,spec_color(GPCR$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(GPCR$Adipose_padj),F,ifelse(GPCR$Adipose_padj<.1,T,F)),color= ifelse(is.na(GPCR$Adipose_padj),"gray",ifelse(GPCR$Adipose_padj<.1, spec_color(GPCR$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(GPCR$Muscle_padj),F,ifelse(GPCR$Muscle_padj<.1,T,F)),color= ifelse(is.na(GPCR$Muscle_padj),"gray",ifelse(GPCR$Muscle_padj<.1,spec_color(GPCR$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 57 | Ccl21 | -2.00e-02 | 9.6e-01 | -6.00e-02 | NA | 2.30e-01 | 5.4e-01 | -1.30e-01 | 8.9e-01 | -6.00e-02 | 9.2e-01 | -3.21e+00 | 0.0e+00 |
| 171 | Htr2a | -5.30e-01 | 1.7e-01 | -1.50e-01 | 6.6e-01 | 1.30e-01 | 8.8e-01 | 8.00e-02 | NA | -4.50e-01 | 4.4e-01 | -2.92e+00 | 0.0e+00 |
| 114 | Fzd10 | -8.10e-01 | 3.0e-02 | -6.60e-01 | 0.0e+00 | -1.10e-01 | 8.9e-01 | 0.00e+00 | NA | -2.80e-01 | NA | -2.69e+00 | 0.0e+00 |
| 92 | Cysltr1 | -7.20e-01 | 2.0e-02 | -5.60e-01 | 1.3e-01 | 2.50e-01 | 7.5e-01 | -5.40e-01 | 3.8e-01 | -9.70e-01 | 1.0e-02 | -2.41e+00 | 0.0e+00 |
| 222 | Pla2g4a | -2.60e-01 | 1.5e-01 | -3.30e-01 | 3.6e-01 | -4.40e-01 | 4.3e-01 | -6.70e-01 | 2.0e-02 | -3.60e-01 | 4.6e-01 | -2.25e+00 | 0.0e+00 |
| 29 | Arhgef16 | 0.00e+00 | 9.9e-01 | 3.00e-02 | 9.8e-01 | 3.80e-01 | NA | -8.00e-02 | NA | -1.21e+00 | 0.0e+00 | -2.24e+00 | 0.0e+00 |
| 20 | Adrb2 | 3.50e-01 | 7.0e-02 | -2.30e-01 | 6.3e-01 | 0.00e+00 | 1.0e+00 | -2.10e-01 | 7.8e-01 | 1.90e-01 | 6.3e-01 | -2.23e+00 | 0.0e+00 |
| 303 | Wnt16 | 2.00e-02 | NA | -3.40e-01 | 4.7e-01 | 4.00e-02 | NA | 3.00e-02 | NA | 1.60e-01 | NA | -2.20e+00 | 0.0e+00 |
| 102 | Edn3 | -6.00e-01 | 0.0e+00 | -3.30e-01 | 4.8e-01 | 3.10e-01 | 6.7e-01 | 4.00e-02 | NA | -3.70e-01 | NA | -2.18e+00 | 0.0e+00 |
| 106 | F2rl1 | 7.80e-01 | 0.0e+00 | -3.50e-01 | 4.5e-01 | 5.00e-02 | 9.5e-01 | -3.80e-01 | 6.1e-01 | 2.80e-01 | 6.0e-01 | -2.04e+00 | 0.0e+00 |
| 153 | Gpr37l1 | -1.70e-01 | 7.0e-01 | -9.00e-02 | 8.5e-01 | -5.40e-01 | 3.9e-01 | -9.00e-02 | NA | -1.20e-01 | NA | -1.98e+00 | 0.0e+00 |
| 308 | Wnt6 | -2.40e-01 | NA | -1.10e-01 | 8.5e-01 | -2.50e-01 | 7.3e-01 | 7.00e-02 | NA | 1.00e-01 | 9.1e-01 | -1.95e+00 | 1.0e-02 |
| 19 | Adra2a | -2.80e-01 | 4.5e-01 | -4.60e-01 | 1.0e-02 | 4.70e-01 | 1.6e-01 | -7.00e-02 | NA | -2.50e-01 | 7.0e-01 | -1.94e+00 | 0.0e+00 |
| 294 | Tshr | 1.60e-01 | 3.7e-01 | 1.10e-01 | 8.2e-01 | 4.20e-01 | 3.2e-01 | 1.50e-01 | NA | 2.70e-01 | 4.6e-01 | -1.93e+00 | 0.0e+00 |
| 56 | Ccl2 | 8.60e-01 | 2.0e-02 | -5.00e-02 | NA | -5.90e-01 | 3.0e-01 | -3.00e-02 | 9.9e-01 | -4.40e-01 | 4.6e-01 | -1.93e+00 | 0.0e+00 |
| 168 | Hrh2 | -8.00e-02 | 9.0e-01 | -4.50e-01 | 2.7e-01 | -2.30e-01 | NA | -4.00e-02 | NA | -2.50e-01 | 6.7e-01 | -1.92e+00 | 0.0e+00 |
| 66 | Ccr5 | -5.10e-01 | 1.0e-02 | -5.90e-01 | 1.0e-02 | -2.40e-01 | 6.2e-01 | 7.00e-02 | 9.1e-01 | -2.10e-01 | 6.8e-01 | -1.90e+00 | 0.0e+00 |
| 25 | Apln | 3.50e-01 | 6.0e-02 | 5.30e-01 | 1.0e-01 | 3.00e-02 | 9.7e-01 | -2.80e-01 | 7.1e-01 | -1.00e+00 | 1.0e-02 | -1.90e+00 | 0.0e+00 |
| 258 | Rasgrp1 | -1.05e+00 | 0.0e+00 | 1.00e-02 | 9.9e-01 | 9.00e-02 | 9.0e-01 | -3.90e-01 | 3.9e-01 | -5.50e-01 | 1.5e-01 | -1.87e+00 | 0.0e+00 |
| 100 | Ect2 | -2.50e-01 | 2.2e-01 | -2.00e-02 | 9.8e-01 | -7.00e-01 | 9.0e-02 | 3.30e-01 | 6.1e-01 | -3.90e-01 | 5.3e-01 | -1.87e+00 | 0.0e+00 |
| 167 | Hrh1 | 4.30e-01 | 2.6e-01 | 1.90e-01 | 5.0e-01 | -1.80e-01 | 7.8e-01 | 4.00e-02 | NA | -4.50e-01 | 4.1e-01 | -1.86e+00 | 0.0e+00 |
| 26 | Aplnr | -3.90e-01 | 4.0e-02 | -4.70e-01 | 1.6e-01 | -8.90e-01 | 0.0e+00 | -2.30e-01 | NA | -1.23e+00 | 0.0e+00 | -1.86e+00 | 0.0e+00 |
| 265 | Rgs2 | -1.80e-01 | 2.7e-01 | 1.00e-01 | 7.8e-01 | -7.00e-01 | 1.6e-01 | 3.00e-02 | 9.8e-01 | -1.00e-01 | 8.8e-01 | -1.76e+00 | 0.0e+00 |
| 65 | Ccr3 | -7.70e-01 | 6.0e-02 | 6.60e-01 | 5.0e-02 | -5.30e-01 | 4.1e-01 | -1.40e-01 | NA | -6.90e-01 | 1.7e-01 | -1.75e+00 | 1.0e-02 |
| 5 | Ackr4 | 1.07e+00 | 0.0e+00 | -2.10e-01 | 7.1e-01 | -1.10e-01 | 8.9e-01 | -8.60e-01 | 0.0e+00 | 2.90e-01 | 6.4e-01 | -1.75e+00 | 0.0e+00 |
| 24 | Anxa1 | 1.50e-01 | 6.3e-01 | 4.00e-02 | 9.7e-01 | -5.00e-01 | NA | -2.00e-01 | NA | 1.00e-02 | 9.9e-01 | -1.74e+00 | 0.0e+00 |
| 195 | Nts | -2.00e-02 | 9.7e-01 | 3.10e-01 | 4.8e-01 | 1.70e-01 | 7.4e-01 | 1.70e-01 | NA | 1.60e-01 | NA | -1.70e+00 | 1.0e-02 |
| 277 | Rxfp1 | -4.70e-01 | 2.3e-01 | -7.00e-02 | 9.2e-01 | -6.00e-02 | NA | -1.00e-01 | NA | 1.20e-01 | NA | -1.69e+00 | 0.0e+00 |
| 199 | Oxtr | -2.00e-01 | NA | -2.90e-01 | 5.0e-01 | -9.00e-01 | 8.0e-02 | -2.00e-02 | NA | -2.90e-01 | 5.5e-01 | -1.68e+00 | 0.0e+00 |
| 79 | Cx3cr1 | -1.23e+00 | 0.0e+00 | -5.30e-01 | 3.0e-02 | -6.80e-01 | 1.6e-01 | -5.60e-01 | 3.5e-01 | -9.20e-01 | 5.0e-02 | -1.67e+00 | 1.0e-02 |
| 239 | Prkcd | -5.00e-01 | 0.0e+00 | -4.30e-01 | 2.5e-01 | 7.20e-01 | 5.0e-02 | -9.00e-02 | 8.6e-01 | -4.40e-01 | 2.0e-01 | -1.67e+00 | 0.0e+00 |
| 156 | Gpr68 | -4.00e-01 | 1.7e-01 | -3.40e-01 | 1.7e-01 | 9.00e-02 | 8.9e-01 | -4.30e-01 | NA | -4.90e-01 | 3.9e-01 | -1.66e+00 | 1.0e-02 |
| 48 | Calcr | 0.00e+00 | NA | 1.80e-01 | 6.4e-01 | -6.20e-01 | 2.8e-01 | 4.00e-02 | NA | -3.60e-01 | NA | -1.65e+00 | 0.0e+00 |
| 191 | Ngef | 2.00e-02 | 9.5e-01 | 3.00e-02 | 9.6e-01 | 3.70e-01 | 3.9e-01 | 2.10e-01 | 6.3e-01 | -3.00e-02 | 9.7e-01 | -1.64e+00 | 0.0e+00 |
| 84 | Cxcl13 | -5.30e-01 | 2.4e-01 | -3.70e-01 | 4.0e-01 | -4.60e-01 | 5.1e-01 | -4.60e-01 | 1.1e-01 | -2.60e-01 | 5.9e-01 | -1.63e+00 | 1.0e-02 |
| 252 | Ptgfr | -3.80e-01 | 3.3e-01 | -2.90e-01 | 5.6e-01 | -1.06e+00 | 4.0e-02 | 2.10e-01 | 7.4e-01 | 1.90e-01 | 7.5e-01 | -1.63e+00 | 0.0e+00 |
| 96 | Dgkg | -2.30e-01 | 4.6e-01 | 8.00e-02 | 8.9e-01 | -7.50e-01 | 5.0e-02 | -7.10e-01 | 1.7e-01 | -2.70e-01 | 6.9e-01 | -1.60e+00 | 0.0e+00 |
| 83 | Cxcl12 | -4.50e-01 | 0.0e+00 | -6.50e-01 | 0.0e+00 | -2.50e-01 | 4.1e-01 | -4.90e-01 | 0.0e+00 | -5.70e-01 | 1.0e-02 | -1.56e+00 | 0.0e+00 |
| 81 | Cxcl10 | 6.60e-01 | 2.0e-02 | -3.80e-01 | 3.9e-01 | -2.06e+00 | 0.0e+00 | -2.00e-01 | 8.4e-01 | -7.90e-01 | 8.0e-02 | -1.54e+00 | 0.0e+00 |
| 264 | Rgs18 | -8.00e-01 | 4.0e-02 | -6.00e-02 | NA | 2.50e-01 | 7.5e-01 | -1.70e-01 | 8.7e-01 | -2.20e-01 | 7.6e-01 | -1.54e+00 | 3.0e-02 |
| 246 | Ptafr | -8.00e-02 | 7.4e-01 | 2.80e-01 | 1.8e-01 | 2.50e-01 | 5.6e-01 | 7.00e-02 | 9.1e-01 | -4.40e-01 | 2.6e-01 | -1.54e+00 | 0.0e+00 |
| 226 | Plppr5 | -2.90e-01 | NA | -8.00e-02 | 8.7e-01 | 7.30e-01 | 1.4e-01 | -4.00e-02 | NA | -5.90e-01 | 2.8e-01 | -1.52e+00 | 2.0e-02 |
| 204 | P2ry6 | -8.00e-02 | 8.7e-01 | -2.10e-01 | 7.1e-01 | -7.20e-01 | 1.5e-01 | -3.50e-01 | 6.2e-01 | -6.50e-01 | 1.1e-01 | -1.51e+00 | 0.0e+00 |
| 287 | Tacr3 | -3.70e-01 | NA | -2.70e-01 | 5.4e-01 | -7.00e-02 | 9.4e-01 | -3.00e-02 | NA | -3.70e-01 | NA | -1.51e+00 | 3.0e-02 |
| 181 | Lpar4 | -1.70e-01 | 6.4e-01 | -3.20e-01 | 4.6e-01 | 4.70e-01 | 4.8e-01 | 3.30e-01 | NA | -3.70e-01 | 3.9e-01 | -1.51e+00 | 0.0e+00 |
| 116 | Fzd4 | 5.40e-01 | 0.0e+00 | 1.50e-01 | 6.0e-01 | 3.00e-01 | 2.5e-01 | 4.30e-01 | 1.3e-01 | 3.00e-02 | 9.5e-01 | -1.51e+00 | 0.0e+00 |
| 150 | Gpr176 | -5.10e-01 | 6.0e-02 | 2.70e-01 | 2.8e-01 | 4.30e-01 | 8.0e-02 | 2.30e-01 | NA | -4.20e-01 | 1.4e-01 | -1.49e+00 | 0.0e+00 |
| 237 | Prkar2b | -3.10e-01 | 3.0e-01 | -1.20e-01 | 7.3e-01 | -4.30e-01 | 0.0e+00 | -2.60e-01 | 7.7e-01 | 3.30e-01 | 3.1e-01 | -1.49e+00 | 0.0e+00 |
| 206 | Pde10a | 1.18e+00 | 0.0e+00 | 4.00e-02 | 9.6e-01 | 2.19e+00 | 0.0e+00 | 3.80e-01 | NA | -8.00e-02 | 9.0e-01 | -1.49e+00 | 0.0e+00 |
| 173 | Htr7 | -6.50e-01 | 1.1e-01 | 1.00e-02 | 9.8e-01 | 3.30e-01 | 5.1e-01 | -5.20e-01 | 4.1e-01 | -7.60e-01 | 6.0e-02 | -1.47e+00 | 0.0e+00 |
| 305 | Wnt2b | 2.10e-01 | 6.2e-01 | -5.00e-02 | 9.4e-01 | 3.70e-01 | 3.5e-01 | 7.90e-01 | NA | -1.50e-01 | 8.1e-01 | -1.47e+00 | 4.0e-02 |
| 202 | P2ry12 | 2.40e-01 | 5.3e-01 | -5.20e-01 | 4.0e-02 | -6.00e-02 | 8.4e-01 | -1.20e-01 | 9.1e-01 | -4.00e-01 | 4.7e-01 | -1.46e+00 | 1.0e-02 |
| 143 | Gng10 | -1.50e-01 | 6.0e-01 | 9.00e-02 | 9.0e-01 | -2.70e-01 | 6.6e-01 | -2.00e-01 | 6.1e-01 | 2.00e-01 | 4.6e-01 | -1.44e+00 | 0.0e+00 |
| 117 | Fzd5 | -8.00e-02 | 8.2e-01 | -5.00e-02 | 9.3e-01 | 2.10e-01 | 6.6e-01 | -4.80e-01 | 2.8e-01 | -4.60e-01 | 3.9e-01 | -1.44e+00 | 2.0e-02 |
| 53 | Cck | -1.00e-02 | NA | 2.20e-01 | 7.0e-01 | 0.00e+00 | NA | 3.00e-02 | NA | 1.00e-02 | NA | -1.43e+00 | 2.0e-02 |
| 52 | Camkk1 | 2.60e-01 | 1.9e-01 | 1.40e-01 | 6.2e-01 | -7.50e-01 | 0.0e+00 | -2.00e-01 | 7.4e-01 | -1.40e-01 | 7.1e-01 | -1.37e+00 | 0.0e+00 |
| 155 | Gpr65 | -9.00e-02 | 8.2e-01 | -9.00e-02 | 9.1e-01 | -1.90e-01 | 8.0e-01 | -2.40e-01 | 7.5e-01 | 1.70e-01 | 8.1e-01 | -1.36e+00 | 4.0e-02 |
| 44 | C3 | -2.60e-01 | 3.8e-01 | 2.00e-02 | 9.8e-01 | -5.60e-01 | 3.6e-01 | -6.00e-02 | 7.8e-01 | -2.10e-01 | 7.7e-01 | -1.35e+00 | 1.0e-02 |
| 43 | Btk | -3.20e-01 | 9.0e-02 | -2.70e-01 | 6.1e-01 | 3.50e-01 | 4.7e-01 | -4.70e-01 | 3.9e-01 | -2.40e-01 | 6.8e-01 | -1.35e+00 | 2.0e-02 |
| 3 | Ackr2 | 5.90e-01 | 1.0e-01 | 1.30e-01 | 8.6e-01 | 1.50e-01 | 8.2e-01 | 1.80e-01 | 8.3e-01 | -4.50e-01 | 3.2e-01 | -1.34e+00 | 0.0e+00 |
| 186 | Mc2r | 4.60e-01 | 2.4e-01 | 2.00e-02 | NA | -1.90e-01 | 7.2e-01 | 1.10e-01 | NA | 9.00e-02 | 8.8e-01 | -1.34e+00 | 4.0e-02 |
| 217 | Penk | 5.70e-01 | 7.0e-02 | -1.00e-02 | 9.9e-01 | 7.40e-01 | 0.0e+00 | 8.00e-02 | 9.5e-01 | 9.50e-01 | 0.0e+00 | -1.33e+00 | 1.0e-02 |
| 218 | Pik3cg | -3.50e-01 | 8.0e-02 | -4.10e-01 | 2.5e-01 | -2.50e-01 | 4.1e-01 | -5.60e-01 | 1.8e-01 | -6.80e-01 | 3.0e-02 | -1.32e+00 | 0.0e+00 |
| 201 | P2ry10 | -8.40e-01 | 0.0e+00 | -1.80e-01 | NA | 4.00e-01 | 5.6e-01 | -8.90e-01 | 4.0e-02 | -2.70e-01 | 6.7e-01 | -1.32e+00 | 1.0e-02 |
| 8 | Adcy7 | -5.30e-01 | 0.0e+00 | -8.00e-02 | 8.8e-01 | 1.00e-01 | 8.4e-01 | -4.50e-01 | 4.4e-01 | -2.90e-01 | 4.3e-01 | -1.32e+00 | 0.0e+00 |
| 282 | Sctr | -1.50e-01 | 7.9e-01 | -1.00e-01 | 8.9e-01 | -1.60e-01 | 8.3e-01 | 5.40e-01 | 2.7e-01 | -2.70e-01 | 6.3e-01 | -1.31e+00 | 5.0e-02 |
| 304 | Wnt2 | -4.90e-01 | 3.0e-02 | 1.00e-02 | 9.9e-01 | 5.00e-02 | 9.4e-01 | -4.00e-01 | 5.4e-01 | 6.80e-01 | 1.2e-01 | -1.27e+00 | 1.0e-02 |
| 69 | Ccrl2 | -1.50e-01 | 5.1e-01 | -3.20e-01 | 5.1e-01 | -1.06e+00 | 3.0e-02 | -5.00e-01 | 3.7e-01 | -1.40e-01 | 8.2e-01 | -1.27e+00 | 0.0e+00 |
| 162 | Hcar2 | -7.00e-02 | 8.5e-01 | -3.40e-01 | 4.5e-01 | 5.60e-01 | 1.2e-01 | 3.30e-01 | NA | -9.00e-02 | 9.1e-01 | -1.27e+00 | 6.0e-02 |
| 248 | Ptch2 | -4.20e-01 | 1.3e-01 | -4.90e-01 | 4.0e-02 | -1.00e+00 | 1.0e-02 | 3.60e-01 | 6.3e-01 | -2.00e-02 | 9.8e-01 | -1.26e+00 | 0.0e+00 |
| 140 | Gnb3 | 2.40e-01 | 6.3e-01 | 2.00e-02 | 9.8e-01 | 4.40e-01 | 2.5e-01 | -2.90e-01 | NA | -1.20e-01 | 8.5e-01 | -1.26e+00 | 0.0e+00 |
| 144 | Gng11 | -4.10e-01 | 1.5e-01 | -3.90e-01 | 3.8e-01 | 4.00e-02 | 9.6e-01 | -4.90e-01 | 2.8e-01 | 1.40e-01 | 7.7e-01 | -1.25e+00 | 0.0e+00 |
| 251 | Ptger3 | 8.80e-01 | 0.0e+00 | 7.00e-02 | 9.3e-01 | -4.00e-02 | 9.4e-01 | -8.80e-01 | 0.0e+00 | 3.00e-02 | 9.6e-01 | -1.25e+00 | 2.0e-02 |
| 97 | Dhh | -6.80e-01 | 0.0e+00 | -2.80e-01 | 5.5e-01 | 4.40e-01 | 4.2e-01 | -5.60e-01 | NA | 1.50e-01 | 8.4e-01 | -1.25e+00 | 0.0e+00 |
| 180 | Lpar1 | 6.60e-01 | 0.0e+00 | -1.70e-01 | 5.9e-01 | -3.50e-01 | 8.0e-02 | 1.10e-01 | 9.3e-01 | 2.00e-01 | 7.1e-01 | -1.25e+00 | 0.0e+00 |
| 141 | Gnb4 | -3.20e-01 | 5.0e-02 | -2.90e-01 | 2.8e-01 | 2.50e-01 | 6.2e-01 | -2.30e-01 | 7.3e-01 | -4.30e-01 | 1.7e-01 | -1.24e+00 | 0.0e+00 |
| 73 | Cmklr1 | -5.00e-02 | 8.2e-01 | -3.70e-01 | 3.1e-01 | 4.90e-01 | 7.0e-02 | -3.10e-01 | 5.3e-01 | 8.70e-01 | 0.0e+00 | -1.23e+00 | 0.0e+00 |
| 293 | Trpc6 | -4.20e-01 | 0.0e+00 | -4.60e-01 | 6.0e-02 | -6.40e-01 | 1.2e-01 | -1.70e-01 | 8.7e-01 | -5.60e-01 | 3.1e-01 | -1.22e+00 | 1.0e-02 |
| 78 | Cx3cl1 | 2.80e-01 | 1.8e-01 | -5.00e-02 | 8.7e-01 | -1.16e+00 | 0.0e+00 | -3.20e-01 | 6.5e-01 | -7.10e-01 | 1.0e-02 | -1.21e+00 | 0.0e+00 |
| 223 | Plcb1 | 4.30e-01 | 1.5e-01 | 1.00e-01 | 8.9e-01 | -1.30e-01 | 8.6e-01 | -5.00e-02 | 9.6e-01 | 6.00e-02 | 9.3e-01 | -1.20e+00 | 0.0e+00 |
| 184 | Ltb4r | 5.00e-02 | 9.3e-01 | 1.30e-01 | NA | 7.20e-01 | 2.4e-01 | 1.30e-01 | NA | -7.10e-01 | 8.0e-02 | -1.20e+00 | 3.0e-02 |
| 280 | S1pr2 | -2.00e-01 | 2.9e-01 | -2.70e-01 | 5.0e-01 | -5.50e-01 | 4.0e-02 | -9.30e-01 | 0.0e+00 | -3.20e-01 | 3.4e-01 | -1.20e+00 | 0.0e+00 |
| 257 | Rasgrf2 | -2.60e-01 | 3.6e-01 | -1.60e-01 | 7.3e-01 | 3.40e-01 | 6.3e-01 | -4.00e-01 | NA | -5.00e-01 | 1.5e-01 | -1.19e+00 | 0.0e+00 |
| 301 | Wnt10b | -1.50e-01 | NA | 3.30e-01 | NA | -9.00e-02 | NA | NA | NA | -5.80e-01 | 1.8e-01 | -1.19e+00 | 4.0e-02 |
| 49 | Calcrl | -6.80e-01 | 0.0e+00 | -4.70e-01 | 1.1e-01 | 1.40e-01 | 8.2e-01 | -5.60e-01 | 2.7e-01 | -3.70e-01 | 3.6e-01 | -1.19e+00 | 0.0e+00 |
| 45 | C3ar1 | -7.40e-01 | 0.0e+00 | -3.70e-01 | 3.9e-01 | -2.50e-01 | 5.1e-01 | 1.30e-01 | 8.5e-01 | -1.60e-01 | 8.2e-01 | -1.19e+00 | 1.0e-02 |
| 61 | Ccl7 | 5.20e-01 | 2.3e-01 | 1.80e-01 | NA | -5.60e-01 | 3.7e-01 | -1.00e-02 | NA | -4.90e-01 | 3.7e-01 | -1.19e+00 | 2.0e-02 |
| 62 | Ccr1 | 1.10e-01 | 6.5e-01 | -2.50e-01 | 5.8e-01 | -3.40e-01 | 3.3e-01 | 2.30e-01 | 7.3e-01 | -2.20e-01 | 6.1e-01 | -1.17e+00 | 0.0e+00 |
| 270 | Rgs7 | 3.10e-01 | 9.0e-02 | 1.40e-01 | 5.6e-01 | 1.43e+00 | 0.0e+00 | -1.14e+00 | 0.0e+00 | -1.60e-01 | 7.4e-01 | -1.15e+00 | 7.0e-02 |
| 28 | Arhgef15 | -6.10e-01 | 1.0e-02 | -3.90e-01 | 2.8e-01 | -1.10e-01 | 7.9e-01 | -4.70e-01 | 2.5e-01 | -7.00e-02 | 8.6e-01 | -1.14e+00 | 0.0e+00 |
| 313 | Xcr1 | -6.50e-01 | 6.0e-02 | -1.30e-01 | NA | 1.40e-01 | NA | -2.30e-01 | 7.2e-01 | -3.30e-01 | 5.6e-01 | -1.14e+00 | 1.0e-01 |
| 272 | Rhoa | 3.00e-02 | 9.4e-01 | 0.00e+00 | 1.0e+00 | -3.00e-01 | NA | -1.00e-01 | 8.8e-01 | 0.00e+00 | 1.0e+00 | -1.14e+00 | 0.0e+00 |
| 160 | Grk5 | -7.00e-01 | 0.0e+00 | -5.20e-01 | 5.0e-02 | 3.70e-01 | 2.2e-01 | -2.60e-01 | 6.5e-01 | 2.00e-01 | 5.7e-01 | -1.14e+00 | 0.0e+00 |
| 176 | Itga5 | -2.00e-02 | 9.3e-01 | -1.40e-01 | 8.4e-01 | 9.30e-01 | 0.0e+00 | -2.00e-01 | 2.0e-01 | -2.00e-01 | 5.1e-01 | -1.14e+00 | 0.0e+00 |
| 311 | Wnt9b | -2.90e-01 | 5.1e-01 | -1.00e-01 | 8.9e-01 | 4.79e+00 | 0.0e+00 | -3.40e-01 | 5.1e-01 | 3.00e-01 | 6.6e-01 | -1.12e+00 | NA |
| 170 | Htr1b | -3.80e-01 | 2.9e-01 | -3.80e-01 | 2.6e-01 | 3.00e-02 | 9.8e-01 | 4.00e-02 | NA | -2.00e-02 | 9.8e-01 | -1.12e+00 | 2.0e-02 |
| 107 | F2rl3 | 2.30e-01 | 2.9e-01 | 1.20e-01 | 8.7e-01 | 9.80e-01 | 7.0e-02 | 3.20e-01 | NA | 7.00e-02 | 9.2e-01 | -1.11e+00 | 1.0e-02 |
| 137 | Gnat1 | 2.40e-01 | 6.0e-01 | 5.00e-02 | NA | -9.30e-01 | 1.0e-01 | 3.50e-01 | 5.5e-01 | -5.50e-01 | 3.4e-01 | -1.11e+00 | 1.0e-01 |
| 46 | C5ar1 | 3.00e-02 | 8.9e-01 | -1.40e-01 | 8.3e-01 | 1.00e-01 | 8.0e-01 | 2.90e-01 | 3.9e-01 | -1.30e-01 | 8.0e-01 | -1.08e+00 | 1.0e-02 |
| 244 | Prkx | 7.00e-02 | 8.1e-01 | -1.30e-01 | 7.7e-01 | 6.70e-01 | 3.0e-02 | 3.00e-01 | 1.4e-01 | 6.00e-02 | 9.1e-01 | -1.07e+00 | 0.0e+00 |
| 158 | Gpsm1 | 3.00e-02 | 9.3e-01 | 2.80e-01 | 2.3e-01 | 3.90e-01 | 3.0e-02 | -1.50e-01 | 8.6e-01 | -2.60e-01 | 4.1e-01 | -1.06e+00 | 0.0e+00 |
| 253 | Ptgir | -6.20e-01 | 0.0e+00 | -1.50e-01 | 8.2e-01 | 1.00e-01 | 8.6e-01 | -1.20e-01 | 9.0e-01 | -2.80e-01 | 5.3e-01 | -1.03e+00 | 0.0e+00 |
| 161 | Hcar1 | -1.00e+00 | 1.0e-02 | -2.60e-01 | 5.0e-01 | -8.80e-01 | 3.0e-02 | -2.90e-01 | 7.2e-01 | -9.80e-01 | 0.0e+00 | -9.90e-01 | 8.0e-02 |
| 132 | Gnai1 | 5.80e-01 | 0.0e+00 | 4.00e-02 | 9.3e-01 | 2.00e-02 | 9.6e-01 | 4.00e-02 | 9.7e-01 | -3.20e-01 | 3.5e-01 | -9.60e-01 | 1.0e-02 |
| 274 | Rock1 | -7.00e-02 | 7.9e-01 | -4.00e-01 | 5.0e-02 | 3.00e-02 | 9.4e-01 | 1.70e-01 | 7.1e-01 | 2.00e-01 | 6.1e-01 | -9.50e-01 | 0.0e+00 |
| 101 | Edn1 | 1.10e+00 | 0.0e+00 | 1.00e-01 | 8.7e-01 | 5.10e-01 | 2.7e-01 | -2.60e-01 | 7.6e-01 | -3.00e-02 | 9.7e-01 | -9.50e-01 | 2.0e-02 |
| 134 | Gnai3 | 5.40e-01 | 0.0e+00 | -6.00e-02 | 8.9e-01 | 2.00e-02 | 9.7e-01 | -8.00e-02 | 8.5e-01 | 9.00e-02 | 8.3e-01 | -9.50e-01 | 0.0e+00 |
| 238 | Prkcb | -5.90e-01 | 2.0e-02 | 1.00e-02 | 9.9e-01 | -7.80e-01 | 0.0e+00 | -6.00e-02 | 9.5e-01 | 8.00e-02 | 9.1e-01 | -9.30e-01 | 3.0e-02 |
| 209 | Pde1c | -2.80e-01 | NA | -7.00e-02 | 9.2e-01 | -3.30e-01 | 6.6e-01 | NA | NA | -4.70e-01 | 3.5e-01 | -9.30e-01 | 4.0e-02 |
| 27 | Arhgef10 | -2.00e-02 | 9.4e-01 | 2.00e-02 | 9.7e-01 | 6.50e-01 | 3.0e-02 | -3.70e-01 | 5.2e-01 | -5.00e-01 | 1.0e-02 | -9.10e-01 | 0.0e+00 |
| 183 | Lpar6 | -3.60e-01 | 3.0e-02 | -2.70e-01 | 4.8e-01 | 1.90e-01 | 4.5e-01 | -1.11e+00 | 0.0e+00 | 5.00e-02 | 9.0e-01 | -9.10e-01 | 0.0e+00 |
| 109 | Fgd2 | -4.50e-01 | 7.0e-02 | -1.50e-01 | 7.6e-01 | -5.00e-02 | 9.1e-01 | -3.80e-01 | 2.6e-01 | 2.80e-01 | 4.4e-01 | -9.10e-01 | 0.0e+00 |
| 32 | Arhgef25 | -3.10e-01 | 8.0e-02 | 5.00e-02 | 9.3e-01 | 3.00e-02 | 9.5e-01 | -2.70e-01 | 7.2e-01 | -2.90e-01 | 3.4e-01 | -8.90e-01 | 0.0e+00 |
| 38 | Arhgef5 | 9.00e-02 | 6.4e-01 | -4.60e-01 | 2.3e-01 | -1.50e-01 | 7.1e-01 | -1.00e-01 | 8.6e-01 | -2.80e-01 | 4.8e-01 | -8.90e-01 | 2.0e-02 |
| 261 | Rgs10 | 1.50e-01 | 4.9e-01 | 1.80e-01 | 6.2e-01 | 1.06e+00 | 0.0e+00 | -8.00e-02 | 9.2e-01 | 7.00e-02 | 9.1e-01 | -8.90e-01 | 1.0e-02 |
| 131 | Gna15 | -2.90e-01 | 1.6e-01 | -4.60e-01 | 2.4e-01 | -7.90e-01 | 9.0e-02 | -8.90e-01 | 6.0e-02 | -6.70e-01 | 8.0e-02 | -8.90e-01 | 1.5e-01 |
| 76 | Creb1 | -7.90e-01 | 1.0e-02 | -4.20e-01 | 3.3e-01 | -7.20e-01 | 1.9e-01 | -3.40e-01 | 6.2e-01 | 2.00e-02 | 9.9e-01 | -8.80e-01 | 2.0e-02 |
| 256 | Ramp3 | 1.44e+00 | 0.0e+00 | 1.40e-01 | 8.3e-01 | -1.00e-02 | 9.9e-01 | 2.70e-01 | NA | 1.00e-01 | 9.1e-01 | -8.80e-01 | 2.4e-01 |
| 200 | P2ry1 | 9.00e-02 | 7.4e-01 | -3.10e-01 | 2.5e-01 | 4.60e-01 | 3.0e-01 | -4.00e-01 | 8.0e-02 | 1.00e-02 | 9.9e-01 | -8.80e-01 | 0.0e+00 |
| 151 | Gpr183 | -3.10e-01 | 2.4e-01 | 1.20e-01 | 8.6e-01 | 1.70e-01 | 7.1e-01 | -3.60e-01 | 6.1e-01 | 6.00e-02 | 9.4e-01 | -8.80e-01 | 5.0e-02 |
| 172 | Htr2b | -2.70e-01 | 4.8e-01 | 5.00e-02 | NA | 1.70e-01 | 8.4e-01 | -2.20e-01 | NA | -2.90e-01 | 6.5e-01 | -8.70e-01 | 6.0e-02 |
| 302 | Wnt11 | -6.80e-01 | 0.0e+00 | -2.00e-02 | 9.8e-01 | 3.50e-01 | 6.1e-01 | -5.00e-02 | NA | -6.20e-01 | 2.2e-01 | -8.70e-01 | 1.0e-02 |
| 300 | Vipr2 | -7.70e-01 | 0.0e+00 | 1.40e-01 | 7.2e-01 | -1.60e-01 | 7.6e-01 | -1.40e-01 | 9.0e-01 | -6.90e-01 | 5.0e-02 | -8.70e-01 | 6.0e-02 |
| 113 | Fzd1 | -4.70e-01 | 0.0e+00 | -2.60e-01 | 3.6e-01 | 6.70e-01 | 1.0e-02 | -6.40e-01 | 0.0e+00 | -6.00e-02 | 8.7e-01 | -8.70e-01 | 0.0e+00 |
| 210 | Pde3b | -3.00e-02 | 9.4e-01 | -4.10e-01 | 2.1e-01 | 5.90e-01 | 1.0e-02 | 6.00e-01 | 1.0e-02 | 1.01e+00 | 0.0e+00 | -8.50e-01 | 1.0e-02 |
| 118 | Fzd6 | 1.50e-01 | 3.7e-01 | 1.50e-01 | 7.6e-01 | 5.70e-01 | 9.0e-02 | 4.50e-01 | 3.5e-01 | -2.10e-01 | 6.0e-01 | -8.40e-01 | 0.0e+00 |
| 4 | Ackr3 | 4.10e-01 | 0.0e+00 | 0.00e+00 | 1.0e+00 | 6.90e-01 | 0.0e+00 | -2.50e-01 | 7.5e-01 | 7.00e-02 | 9.2e-01 | -8.40e-01 | 0.0e+00 |
| 298 | Vav3 | -4.70e-01 | 0.0e+00 | -1.70e-01 | 6.6e-01 | -5.70e-01 | 1.0e-02 | -2.60e-01 | 6.0e-01 | 3.30e-01 | 3.8e-01 | -8.40e-01 | 0.0e+00 |
| 292 | Trpc3 | -9.90e-01 | 0.0e+00 | -1.00e-01 | 8.3e-01 | -4.10e-01 | 3.4e-01 | -4.90e-01 | 3.2e-01 | -1.26e+00 | 0.0e+00 | -8.40e-01 | 0.0e+00 |
| 269 | Rgs6 | 1.00e-02 | 9.6e-01 | 6.00e-02 | 9.0e-01 | -2.40e-01 | 4.7e-01 | -2.70e-01 | 7.3e-01 | -3.80e-01 | 4.7e-01 | -8.40e-01 | 1.0e-02 |
| 268 | Rgs4 | 5.30e-01 | 0.0e+00 | -2.30e-01 | 5.0e-01 | 4.00e-02 | 9.2e-01 | -5.20e-01 | 2.1e-01 | -2.50e-01 | 5.4e-01 | -8.30e-01 | 0.0e+00 |
| 90 | Cxcr4 | -7.00e-01 | 0.0e+00 | -6.30e-01 | 3.0e-02 | -2.50e-01 | 6.0e-01 | 3.80e-01 | 4.9e-01 | -2.30e-01 | 6.5e-01 | -8.30e-01 | 0.0e+00 |
| 85 | Cxcl16 | 1.90e-01 | 1.8e-01 | -2.80e-01 | 5.7e-01 | -8.00e-02 | 8.8e-01 | -5.00e-02 | 9.6e-01 | -1.40e-01 | 8.1e-01 | -8.30e-01 | 0.0e+00 |
| 235 | Prex1 | 6.00e-02 | 7.5e-01 | -3.00e-02 | 9.3e-01 | 5.30e-01 | 1.0e-02 | -5.30e-01 | 8.0e-02 | -4.40e-01 | 9.0e-02 | -8.20e-01 | 0.0e+00 |
| 297 | Vav2 | -1.90e-01 | 1.0e-01 | 1.90e-01 | 3.3e-01 | 2.00e-02 | 9.5e-01 | -8.00e-02 | 7.8e-01 | -5.40e-01 | 0.0e+00 | -8.10e-01 | 0.0e+00 |
| 165 | Hebp1 | 4.50e-01 | 0.0e+00 | 2.50e-01 | 4.8e-01 | 4.80e-01 | 7.0e-02 | -5.00e-02 | 9.3e-01 | 2.50e-01 | 3.7e-01 | -8.10e-01 | 0.0e+00 |
| 207 | Pde1a | -1.40e-01 | 6.5e-01 | -1.00e-01 | 8.4e-01 | -6.50e-01 | 5.0e-02 | -2.20e-01 | 7.8e-01 | -7.00e-02 | 9.0e-01 | -8.00e-01 | 3.0e-02 |
| 104 | Ednrb | -1.20e-01 | 6.8e-01 | -5.00e-02 | 9.4e-01 | -5.40e-01 | 1.0e-01 | -7.90e-01 | 3.0e-02 | -6.20e-01 | 1.0e-02 | -8.00e-01 | 0.0e+00 |
| 21 | Adrb3 | -2.60e-01 | 6.0e-02 | -1.00e-01 | NA | -2.58e+00 | 0.0e+00 | -2.80e-01 | NA | -2.51e+00 | 0.0e+00 | -7.80e-01 | 2.2e-01 |
| 6 | Adcy4 | -2.80e-01 | 6.0e-02 | -6.20e-01 | 5.0e-02 | -1.60e-01 | 6.7e-01 | -2.70e-01 | 5.0e-01 | -3.60e-01 | 1.2e-01 | -7.80e-01 | 0.0e+00 |
| 105 | F2r | 2.40e-01 | 2.0e-02 | 1.10e-01 | 6.3e-01 | -6.70e-01 | 0.0e+00 | -3.00e-01 | 6.8e-01 | 3.50e-01 | 3.2e-01 | -7.80e-01 | 0.0e+00 |
| 12 | Adgre5 | -1.38e+00 | 0.0e+00 | -3.50e-01 | 1.6e-01 | 4.40e-01 | 3.0e-02 | -3.60e-01 | 2.9e-01 | -2.10e-01 | 2.9e-01 | -7.80e-01 | 0.0e+00 |
| 99 | Ece2 | 1.80e-01 | 4.8e-01 | 1.30e-01 | 7.0e-01 | -1.10e-01 | 8.5e-01 | -1.00e-01 | 9.4e-01 | -1.60e-01 | 7.3e-01 | -7.70e-01 | 8.0e-02 |
| 220 | Pik3r3 | -3.00e-01 | 1.7e-01 | -2.10e-01 | 5.9e-01 | -3.20e-01 | 2.2e-01 | 1.20e-01 | 9.2e-01 | 2.00e-02 | 9.8e-01 | -7.70e-01 | 5.0e-02 |
| 227 | Plxnb1 | -5.00e-02 | 7.7e-01 | 1.00e-01 | 7.0e-01 | 3.00e-02 | 9.3e-01 | 7.90e-01 | 0.0e+00 | -2.80e-01 | 5.8e-01 | -7.60e-01 | 1.0e-02 |
| 307 | Wnt5a | -8.40e-01 | 0.0e+00 | -4.80e-01 | 3.0e-02 | 1.00e+00 | 0.0e+00 | -4.60e-01 | 4.9e-01 | -1.36e+00 | 0.0e+00 | -7.60e-01 | 1.0e-02 |
| 110 | Fgd3 | 2.00e-02 | 9.6e-01 | -8.00e-02 | 8.3e-01 | 6.00e-02 | 8.8e-01 | -4.00e-02 | 9.7e-01 | -3.40e-01 | 3.6e-01 | -7.60e-01 | 3.0e-02 |
| 74 | Cnr1 | 2.40e-01 | 5.4e-01 | -3.00e-02 | 9.6e-01 | -1.36e+00 | 0.0e+00 | -4.40e-01 | 5.2e-01 | -3.80e-01 | 4.8e-01 | -7.60e-01 | 1.0e-01 |
| 188 | Mc5r | 1.08e+00 | 0.0e+00 | 6.10e-01 | NA | -3.40e-01 | 6.2e-01 | NA | NA | 2.53e+00 | 0.0e+00 | -7.60e-01 | 1.1e-01 |
| 77 | Crhr2 | -3.10e-01 | NA | 1.30e-01 | 7.4e-01 | -4.30e-01 | NA | 0.00e+00 | NA | -7.70e-01 | 0.0e+00 | -7.50e-01 | 3.0e-02 |
| 42 | Bdkrb2 | -2.00e-01 | 5.4e-01 | 1.70e-01 | 7.8e-01 | 8.10e-01 | 0.0e+00 | -5.00e-02 | 9.7e-01 | -6.00e-02 | 9.4e-01 | -7.50e-01 | 2.0e-02 |
| 11 | Adgre1 | -8.30e-01 | 0.0e+00 | -2.20e-01 | 6.5e-01 | -3.10e-01 | 2.5e-01 | -2.00e-01 | 6.5e-01 | -2.50e-01 | 5.5e-01 | -7.50e-01 | 2.0e-02 |
| 115 | Fzd2 | -5.10e-01 | 1.0e-02 | -5.00e-01 | 1.2e-01 | -4.90e-01 | 2.6e-01 | -2.10e-01 | 8.2e-01 | -6.40e-01 | 2.2e-01 | -7.50e-01 | 1.0e-02 |
| 283 | Smo | -7.10e-01 | 0.0e+00 | -6.00e-02 | 9.1e-01 | -5.10e-01 | 1.0e-02 | -3.80e-01 | 2.0e-01 | -4.40e-01 | 9.0e-02 | -7.30e-01 | 0.0e+00 |
| 145 | Gng2 | -3.50e-01 | 2.0e-02 | 1.10e-01 | 4.8e-01 | -2.00e-02 | 9.7e-01 | -5.20e-01 | 3.0e-02 | 1.90e-01 | 6.4e-01 | -7.20e-01 | 0.0e+00 |
| 112 | Fn1 | 1.10e-01 | 5.8e-01 | -2.00e-02 | 9.9e-01 | -1.70e-01 | 7.5e-01 | -2.00e-02 | 9.8e-01 | 3.00e-02 | 9.5e-01 | -7.10e-01 | 7.0e-02 |
| 64 | Ccr2 | -7.20e-01 | 8.0e-02 | -4.00e-02 | NA | -2.30e-01 | NA | 1.00e-02 | NA | -2.00e-01 | 8.0e-01 | -7.00e-01 | 3.2e-01 |
| 185 | Mapk3 | 2.40e-01 | 5.0e-02 | 4.00e-02 | 9.5e-01 | 1.10e-01 | 7.1e-01 | 4.40e-01 | 5.0e-02 | 5.00e-02 | 9.3e-01 | -6.90e-01 | 0.0e+00 |
| 108 | Ffar4 | -2.90e-01 | 2.9e-01 | 1.60e-01 | NA | 1.50e-01 | 8.6e-01 | -1.00e-01 | NA | -7.20e-01 | 1.0e-02 | -6.70e-01 | 3.7e-01 |
| 216 | Pde8a | 4.10e-01 | 0.0e+00 | -5.00e-02 | 9.0e-01 | -1.00e-02 | 9.8e-01 | 1.70e-01 | 4.8e-01 | 2.30e-01 | 4.9e-01 | -6.60e-01 | 1.0e-02 |
| 314 | Xk | -5.30e-01 | 2.0e-02 | -4.00e-02 | 9.6e-01 | -2.40e-01 | 7.1e-01 | -4.70e-01 | 2.8e-01 | -5.20e-01 | 3.1e-01 | -6.50e-01 | 0.0e+00 |
| 31 | Arhgef2 | 7.00e-02 | 6.7e-01 | -1.40e-01 | 5.5e-01 | 9.00e-02 | 7.2e-01 | -2.00e-01 | 3.8e-01 | 2.50e-01 | 6.0e-02 | -6.50e-01 | 0.0e+00 |
| 121 | Fzd9 | 1.68e+00 | 0.0e+00 | 8.30e-01 | 0.0e+00 | 9.70e-01 | 2.0e-02 | -1.90e-01 | NA | -5.00e-02 | NA | -6.50e-01 | 1.2e-01 |
| 247 | Ptch1 | -3.00e-01 | 1.0e-02 | -1.09e+00 | 0.0e+00 | 3.40e-01 | 1.8e-01 | -2.00e-01 | 4.8e-01 | -1.20e-01 | 7.5e-01 | -6.50e-01 | 0.0e+00 |
| 34 | Arhgef3 | -2.70e-01 | 6.0e-02 | 2.00e-01 | 3.8e-01 | -3.90e-01 | 2.0e-02 | -4.80e-01 | 6.0e-02 | -3.00e-02 | 9.5e-01 | -6.40e-01 | 1.0e-02 |
| 40 | Arhgef9 | -1.40e-01 | 5.5e-01 | 5.00e-02 | 9.1e-01 | -3.00e-01 | 3.8e-01 | 3.00e-02 | 9.8e-01 | -2.40e-01 | 4.6e-01 | -6.40e-01 | 0.0e+00 |
| 159 | Gpsm2 | 5.40e-01 | 1.0e-02 | 8.00e-02 | 8.8e-01 | -1.40e-01 | 8.6e-01 | -4.30e-01 | 7.0e-02 | 1.39e+00 | 0.0e+00 | -6.30e-01 | 7.0e-02 |
| 55 | Ccl19 | -7.90e-01 | 4.0e-02 | -7.00e-02 | 9.0e-01 | 1.20e-01 | 7.7e-01 | -3.80e-01 | 4.8e-01 | -2.00e-01 | 8.0e-01 | -6.10e-01 | 4.1e-01 |
| 262 | Rgs14 | -4.60e-01 | 1.0e-02 | 1.50e-01 | 7.7e-01 | -3.80e-01 | 4.8e-01 | -2.70e-01 | 7.3e-01 | -5.10e-01 | 1.0e-01 | -6.00e-01 | 8.0e-02 |
| 35 | Arhgef33 | -8.00e-02 | 8.9e-01 | 4.10e-01 | 3.2e-01 | -8.70e-01 | 1.0e-02 | -2.00e-02 | NA | -2.20e-01 | NA | -5.80e-01 | NA |
| 182 | Lpar5 | -7.40e-01 | 4.0e-02 | -2.80e-01 | 5.6e-01 | -2.00e-02 | 9.8e-01 | 1.00e-02 | 1.0e+00 | -2.50e-01 | 6.8e-01 | -5.60e-01 | 4.6e-01 |
| 89 | Cxcr3 | 8.00e-02 | 8.8e-01 | -1.00e-01 | NA | -9.00e-01 | 5.0e-02 | -3.90e-01 | 5.9e-01 | -4.70e-01 | 3.1e-01 | -5.50e-01 | 4.5e-01 |
| 59 | Ccl4 | -7.60e-01 | 0.0e+00 | -1.90e-01 | NA | -5.30e-01 | 2.9e-01 | -4.10e-01 | 3.6e-01 | -7.60e-01 | 9.0e-02 | -5.50e-01 | NA |
| 139 | Gnaz | -5.00e-01 | 2.3e-01 | 6.00e-02 | 8.8e-01 | -1.04e+00 | 1.0e-02 | -4.30e-01 | NA | -3.90e-01 | 5.3e-01 | -5.50e-01 | NA |
| 30 | Arhgef19 | -4.10e-01 | 1.6e-01 | -2.10e-01 | 5.7e-01 | -2.10e-01 | 7.7e-01 | -1.02e+00 | 0.0e+00 | 7.00e-02 | 9.3e-01 | -5.40e-01 | 4.7e-01 |
| 229 | Ppp2ca | 1.30e-01 | 7.3e-01 | -6.00e-02 | 9.2e-01 | 2.90e-01 | 5.9e-01 | 1.07e+00 | 0.0e+00 | 4.80e-01 | 2.5e-01 | -5.40e-01 | 1.0e-01 |
| 285 | Sstr1 | 5.40e-01 | 1.0e-02 | -1.50e-01 | 6.6e-01 | 8.80e-01 | 4.0e-02 | -1.00e-01 | NA | -4.30e-01 | NA | -5.10e-01 | 4.8e-01 |
| 224 | Plcb2 | -2.00e-02 | 9.4e-01 | -6.50e-01 | 5.0e-02 | -3.20e-01 | 5.7e-01 | -2.70e-01 | 5.4e-01 | -2.00e-01 | 6.2e-01 | -5.10e-01 | 2.9e-01 |
| 169 | Hrh3 | -2.90e-01 | 3.5e-01 | 2.00e-01 | 4.1e-01 | -3.50e-01 | 6.3e-01 | 9.00e-02 | NA | -1.59e+00 | 0.0e+00 | -4.90e-01 | 5.3e-01 |
| 230 | Ppp2cb | 9.00e-02 | 5.4e-01 | -2.00e-02 | 9.8e-01 | 6.00e-01 | 6.0e-02 | -1.40e-01 | 8.1e-01 | 3.10e-01 | 3.8e-01 | -4.70e-01 | 9.0e-02 |
| 221 | Pik3r5 | -1.20e-01 | 5.0e-01 | 5.80e-01 | 2.0e-02 | 8.00e-01 | 1.0e-02 | 2.00e-02 | 9.9e-01 | -3.00e-02 | 9.7e-01 | -4.70e-01 | 3.4e-01 |
| 23 | Agtr1a | 3.30e-01 | 6.0e-02 | 6.00e-02 | 9.4e-01 | 5.00e-01 | 1.0e-02 | -4.20e-01 | 5.0e-02 | 6.70e-01 | 0.0e+00 | -4.60e-01 | 5.0e-02 |
| 148 | Gpr15 | -5.40e-01 | 2.1e-01 | -5.00e-02 | NA | 2.24e+00 | 0.0e+00 | 3.00e-02 | NA | -4.00e-02 | NA | -4.50e-01 | NA |
| 67 | Ccr6 | -7.80e-01 | 2.0e-02 | -5.00e-02 | NA | 4.80e-01 | NA | -2.60e-01 | NA | -1.00e-02 | NA | -4.10e-01 | NA |
| 254 | Ramp1 | -1.70e-01 | 7.3e-01 | 2.80e-01 | 4.8e-01 | -1.10e-01 | 8.9e-01 | -7.70e-01 | 8.0e-02 | 1.70e-01 | 7.7e-01 | -4.10e-01 | 2.3e-01 |
| 198 | Oprd1 | 2.00e-02 | NA | 2.00e-02 | 9.8e-01 | 1.02e+00 | 5.0e-02 | -2.00e-02 | NA | -8.10e-01 | NA | -4.00e-01 | 6.2e-01 |
| 7 | Adcy5 | 5.90e-01 | 0.0e+00 | 0.00e+00 | 9.9e-01 | -2.10e-01 | 3.6e-01 | -5.00e-02 | 9.4e-01 | 6.00e-01 | 3.0e-02 | -3.90e-01 | 2.1e-01 |
| 103 | Ednra | -7.30e-01 | 0.0e+00 | -2.90e-01 | 2.7e-01 | -2.60e-01 | 4.5e-01 | -1.22e+00 | 0.0e+00 | -6.80e-01 | 0.0e+00 | -3.80e-01 | 1.3e-01 |
| 138 | Gnat2 | 4.30e-01 | 2.0e-02 | -2.10e-01 | NA | 1.78e+00 | 0.0e+00 | -2.40e-01 | 7.4e-01 | 4.50e-01 | 3.0e-01 | -3.80e-01 | 6.0e-01 |
| 47 | C5ar2 | -2.10e-01 | 2.4e-01 | -2.20e-01 | 6.6e-01 | 5.00e-02 | 9.3e-01 | -7.40e-01 | 0.0e+00 | 1.70e-01 | 8.3e-01 | -3.60e-01 | 5.4e-01 |
| 208 | Pde1b | 5.70e-01 | 1.5e-01 | -5.00e-02 | 8.9e-01 | -6.10e-01 | 8.0e-02 | 1.70e-01 | NA | -3.20e-01 | 1.5e-01 | -3.60e-01 | 4.7e-01 |
| 242 | Prkch | 7.60e-01 | 0.0e+00 | -8.00e-02 | 9.1e-01 | -1.30e-01 | 7.9e-01 | 5.00e-02 | 9.6e-01 | -6.00e-02 | 8.8e-01 | -3.50e-01 | 1.0e-01 |
| 279 | S1pr1 | 5.20e-01 | 0.0e+00 | -3.70e-01 | 0.0e+00 | 2.60e-01 | 3.6e-01 | -7.50e-01 | 0.0e+00 | 3.10e-01 | 1.3e-01 | -3.50e-01 | 1.4e-01 |
| 263 | Rgs16 | 2.63e+00 | 0.0e+00 | -4.00e-02 | 9.5e-01 | 4.20e-01 | 3.4e-01 | -3.40e-01 | 6.2e-01 | 9.00e-01 | 0.0e+00 | -3.40e-01 | 3.4e-01 |
| 39 | Arhgef6 | -9.00e-02 | 8.1e-01 | -1.00e-02 | 9.9e-01 | -8.10e-01 | 0.0e+00 | 2.00e-02 | 9.8e-01 | -7.00e-02 | 8.9e-01 | -3.30e-01 | 1.1e-01 |
| 286 | Sstr4 | -8.60e-01 | 0.0e+00 | -3.50e-01 | 2.8e-01 | 5.40e-01 | 4.1e-01 | -1.20e-01 | NA | -8.00e-02 | NA | -3.30e-01 | NA |
| 15 | Adora2b | 9.20e-01 | 0.0e+00 | -3.60e-01 | 3.1e-01 | 5.80e-01 | 2.2e-01 | -1.80e-01 | 8.6e-01 | -7.00e-02 | 9.4e-01 | -3.30e-01 | 5.5e-01 |
| 1 | Abhd6 | -2.00e-01 | 1.5e-01 | 0.00e+00 | 9.9e-01 | -8.10e-01 | 0.0e+00 | -1.00e-01 | 8.5e-01 | -3.60e-01 | 1.0e-02 | -3.00e-01 | 1.8e-01 |
| 255 | Ramp2 | 3.00e-02 | 8.9e-01 | 1.20e-01 | 8.3e-01 | 5.90e-01 | 5.0e-02 | -1.10e-01 | 9.2e-01 | 9.00e-02 | 9.0e-01 | -2.50e-01 | 4.8e-01 |
| 146 | Gnrh1 | 6.30e-01 | 5.0e-02 | 4.00e-02 | 9.7e-01 | 6.30e-01 | 1.3e-01 | 3.80e-01 | 5.3e-01 | 4.40e-01 | 2.6e-01 | -2.50e-01 | 6.5e-01 |
| 260 | Rgs1 | 1.60e-01 | 6.2e-01 | 6.50e-01 | 4.0e-02 | 6.10e-01 | 1.2e-01 | 1.27e+00 | 0.0e+00 | 6.50e-01 | 1.7e-01 | -2.20e-01 | 7.6e-01 |
| 18 | Adra1d | -9.20e-01 | 0.0e+00 | 2.60e-01 | 6.1e-01 | 8.90e-01 | 2.0e-02 | 2.90e-01 | NA | -1.92e+00 | 0.0e+00 | -1.80e-01 | 6.9e-01 |
| 22 | Agt | -2.60e-01 | 6.1e-01 | 2.70e-01 | 1.2e-01 | 1.10e+00 | 1.0e-02 | 8.70e-01 | 0.0e+00 | 1.07e+00 | 0.0e+00 | -1.70e-01 | 7.2e-01 |
| 94 | Daglb | 1.50e-01 | 1.5e-01 | -3.00e-02 | 9.4e-01 | -7.20e-01 | 0.0e+00 | -2.70e-01 | 2.0e-02 | -1.30e-01 | 7.7e-01 | -1.70e-01 | 4.8e-01 |
| 127 | Glp1r | 1.00e-02 | 9.9e-01 | -1.70e-01 | 7.0e-01 | 9.60e-01 | 7.0e-02 | -1.40e-01 | NA | NA | NA | -1.50e-01 | NA |
| 203 | P2ry14 | 7.90e-01 | 0.0e+00 | 3.90e-01 | 3.7e-01 | -9.50e-01 | 0.0e+00 | -3.60e-01 | 4.2e-01 | -2.00e-02 | 9.7e-01 | -1.30e-01 | 7.6e-01 |
| 281 | S1pr5 | -8.30e-01 | 0.0e+00 | -8.00e-02 | 8.6e-01 | -1.50e-01 | 8.6e-01 | 7.00e-02 | NA | -8.30e-01 | 6.0e-02 | -1.30e-01 | 8.8e-01 |
| 37 | Arhgef40 | -3.70e-01 | 0.0e+00 | -1.90e-01 | 3.9e-01 | 4.60e-01 | 1.5e-01 | -2.30e-01 | 2.2e-01 | -6.00e-01 | 0.0e+00 | -1.30e-01 | 5.1e-01 |
| 33 | Arhgef26 | -5.80e-01 | 0.0e+00 | -5.00e-01 | 0.0e+00 | -1.17e+00 | 0.0e+00 | -1.05e+00 | 0.0e+00 | -3.70e-01 | 4.5e-01 | -1.10e-01 | 8.3e-01 |
| 291 | Trh | 1.60e+00 | 0.0e+00 | 9.00e-02 | 9.1e-01 | 4.00e-02 | NA | -7.00e-02 | NA | 4.40e-01 | 4.5e-01 | -8.00e-02 | 9.2e-01 |
| 289 | Tiam1 | -4.30e-01 | 1.3e-01 | 1.00e-01 | 8.6e-01 | -1.01e+00 | 0.0e+00 | 4.00e-02 | 9.8e-01 | 5.40e-01 | 1.4e-01 | -7.00e-02 | 9.0e-01 |
| 125 | Ghrl | -1.00e-02 | 9.9e-01 | -2.20e-01 | 7.0e-01 | 1.32e+00 | 1.0e-02 | 4.50e-01 | NA | 7.00e-02 | NA | -4.00e-02 | 9.6e-01 |
| 275 | Rock2 | -6.00e-02 | 8.6e-01 | -1.10e-01 | 8.3e-01 | -5.40e-01 | 1.2e-01 | -4.10e-01 | 2.2e-01 | 8.20e-01 | 1.0e-02 | -3.00e-02 | 8.6e-01 |
| 68 | Ccr9 | -8.20e-01 | 1.0e-02 | 5.00e-02 | NA | -6.00e-02 | NA | 1.00e-02 | 1.0e+00 | -1.00e-01 | NA | -3.00e-02 | NA |
| 154 | Gpr55 | -6.80e-01 | 9.0e-02 | 1.30e-01 | NA | -3.80e-01 | 3.1e-01 | -3.40e-01 | NA | -2.40e-01 | NA | -3.00e-02 | NA |
| 164 | Hcrtr2 | -4.40e-01 | 3.4e-01 | -7.00e-01 | 0.0e+00 | -1.59e+00 | 0.0e+00 | -1.70e-01 | NA | NA | NA | -3.00e-02 | NA |
| 124 | Ghrhr | 1.43e+00 | 0.0e+00 | 2.90e-01 | NA | 5.40e-01 | 4.1e-01 | 5.70e-01 | NA | 1.90e-01 | NA | -3.00e-02 | 9.7e-01 |
| 120 | Fzd8 | 3.30e-01 | 2.1e-01 | -1.00e-01 | 8.8e-01 | -4.30e-01 | 1.9e-01 | -1.40e-01 | 7.9e-01 | -1.06e+00 | 0.0e+00 | -1.00e-02 | 9.8e-01 |
| 189 | Mcf2l | 4.70e-01 | 0.0e+00 | -1.00e-02 | 9.9e-01 | 2.70e-01 | 2.3e-01 | 4.00e-01 | 1.0e-01 | 5.90e-01 | 0.0e+00 | -1.00e-02 | 9.6e-01 |
| 16 | Adra1a | -9.80e-01 | 0.0e+00 | -1.30e-01 | 8.6e-01 | -7.90e-01 | 1.7e-01 | -9.00e-02 | NA | -1.24e+00 | 0.0e+00 | -1.00e-02 | 9.9e-01 |
| 179 | Kpna2 | 5.30e-01 | 0.0e+00 | 2.00e-01 | 5.3e-01 | 1.10e-01 | 7.6e-01 | 7.80e-01 | 0.0e+00 | 5.40e-01 | 3.0e-02 | -1.00e-02 | 9.8e-01 |
| 88 | Cxcl6 | 1.48e+00 | 0.0e+00 | -2.70e-01 | 5.8e-01 | -3.00e-02 | NA | 1.90e-01 | NA | -2.40e-01 | NA | 4.00e-02 | NA |
| 122 | Gal | 2.94e+00 | 0.0e+00 | 2.10e-01 | 7.2e-01 | 1.76e+00 | 0.0e+00 | 3.00e-02 | NA | 1.01e+00 | 2.0e-02 | 4.00e-02 | NA |
| 231 | Ppp2r1b | 8.00e-02 | 5.0e-01 | 5.00e-02 | 9.0e-01 | 7.60e-01 | 0.0e+00 | -1.30e-01 | 7.9e-01 | -5.30e-01 | 1.0e-02 | 6.00e-02 | 8.4e-01 |
| 126 | Gipr | -1.60e-01 | 7.9e-01 | 1.40e-01 | 7.8e-01 | 1.96e+00 | 0.0e+00 | -1.80e-01 | NA | -2.20e-01 | 6.3e-01 | 6.00e-02 | 9.5e-01 |
| 133 | Gnai2 | 7.10e-01 | 0.0e+00 | 2.10e-01 | 5.0e-01 | 1.00e-02 | 9.8e-01 | -3.00e-02 | 9.5e-01 | 2.40e-01 | 3.5e-01 | 8.00e-02 | 7.0e-01 |
| 54 | Ccl17 | 9.20e-01 | 3.0e-02 | -3.00e-02 | NA | NA | NA | 1.00e-02 | NA | 1.80e-01 | NA | 9.00e-02 | NA |
| 58 | Ccl28 | -7.10e-01 | 9.0e-02 | 1.60e-01 | NA | -1.00e-02 | NA | 2.10e-01 | NA | 1.50e-01 | NA | 9.00e-02 | NA |
| 80 | Cxcl1 | 1.85e+00 | 0.0e+00 | -1.00e-02 | NA | 2.00e-01 | NA | 1.30e-01 | 9.1e-01 | 7.00e-02 | 9.3e-01 | 9.00e-02 | NA |
| 267 | Rgs3 | -5.60e-01 | 0.0e+00 | 6.00e-02 | 9.1e-01 | 6.70e-01 | 5.0e-02 | -2.18e+00 | 0.0e+00 | -3.90e-01 | 1.5e-01 | 1.00e-01 | 5.9e-01 |
| 284 | Sos1 | 2.00e-02 | 9.6e-01 | -2.30e-01 | 5.7e-01 | 1.10e-01 | 7.1e-01 | 5.90e-01 | 1.0e-02 | -1.00e-02 | 9.8e-01 | 1.00e-01 | 6.3e-01 |
| 82 | Cxcl11 | -3.00e-02 | 9.7e-01 | 1.00e-01 | NA | -1.01e+00 | 7.0e-02 | -1.21e+00 | 0.0e+00 | -9.60e-01 | 1.0e-02 | 1.00e-01 | 8.8e-01 |
| 213 | Pde4c | 7.40e-01 | 0.0e+00 | -1.60e-01 | 8.0e-01 | -4.60e-01 | 3.8e-01 | 6.30e-01 | 2.2e-01 | -2.90e-01 | 4.9e-01 | 1.10e-01 | 7.1e-01 |
| 233 | Ppp3cc | 1.10e-01 | 4.6e-01 | -1.50e-01 | 6.4e-01 | -6.70e-01 | 1.0e-02 | 3.70e-01 | 1.1e-01 | 7.00e-02 | 8.6e-01 | 1.20e-01 | 3.3e-01 |
| 157 | Gpr83 | 5.00e-02 | NA | -2.40e-01 | 8.0e-02 | 1.04e+00 | 0.0e+00 | -4.00e-02 | NA | 6.00e-02 | NA | 1.30e-01 | NA |
| 130 | Gna14 | -4.60e-01 | 0.0e+00 | -2.00e-01 | 6.7e-01 | 3.90e-01 | 2.1e-01 | -7.90e-01 | 5.0e-02 | -4.00e-01 | 4.1e-01 | 1.40e-01 | 8.2e-01 |
| 241 | Prkcg | 7.30e-01 | 0.0e+00 | 9.00e-02 | 8.7e-01 | -5.60e-01 | 1.6e-01 | 2.50e-01 | 7.7e-01 | 4.00e-02 | 9.6e-01 | 1.40e-01 | 7.2e-01 |
| 215 | Pde7a | 2.80e-01 | 4.0e-01 | -1.70e-01 | 7.3e-01 | 4.60e-01 | 1.0e-02 | -6.00e-01 | 0.0e+00 | -6.40e-01 | 0.0e+00 | 1.50e-01 | 5.3e-01 |
| 75 | Cnr2 | -7.00e-02 | 7.9e-01 | 9.00e-01 | 0.0e+00 | 1.90e-01 | 6.1e-01 | -1.10e-01 | 8.5e-01 | 3.30e-01 | 3.1e-01 | 1.60e-01 | 7.3e-01 |
| 71 | Chrm1 | -5.00e-02 | NA | 1.00e-01 | 8.9e-01 | -1.24e+00 | 1.0e-02 | NA | NA | -4.00e-02 | NA | 1.60e-01 | NA |
| 86 | Cxcl2 | 2.74e+00 | 0.0e+00 | 5.20e-01 | NA | 3.50e-01 | NA | 1.20e-01 | NA | 2.60e-01 | NA | 1.60e-01 | NA |
| 271 | Rgs9 | -1.70e-01 | 7.7e-01 | 2.40e-01 | 1.8e-01 | 7.00e-01 | 8.0e-02 | 1.30e-01 | NA | -1.30e-01 | NA | 1.60e-01 | NA |
| 70 | Cd55 | 1.70e-01 | 2.7e-01 | -3.00e-01 | 3.4e-01 | 1.62e+00 | 0.0e+00 | -4.70e-01 | 4.5e-01 | 2.30e-01 | 6.3e-01 | 1.60e-01 | 4.5e-01 |
| 212 | Pde4b | 4.00e-01 | 7.0e-02 | -3.00e-02 | 9.5e-01 | 1.32e+00 | 0.0e+00 | 1.00e-01 | 9.2e-01 | -9.00e-02 | 8.6e-01 | 1.80e-01 | 6.1e-01 |
| 63 | Ccr10 | -8.50e-01 | 4.0e-02 | 1.00e-01 | 8.9e-01 | 1.40e-01 | 8.7e-01 | -2.80e-01 | NA | -6.50e-01 | 2.2e-01 | 1.80e-01 | 8.4e-01 |
| 119 | Fzd7 | -3.10e-01 | 2.0e-02 | -3.90e-01 | 3.8e-01 | 5.90e-01 | 4.0e-02 | 5.00e-01 | 1.4e-01 | 3.60e-01 | 2.9e-01 | 1.90e-01 | 2.2e-01 |
| 177 | Itpr1 | 2.50e-01 | 3.2e-01 | -1.80e-01 | 5.9e-01 | 4.80e-01 | 0.0e+00 | 1.08e+00 | 0.0e+00 | 2.80e-01 | 2.7e-01 | 2.20e-01 | 2.3e-01 |
| 234 | Ppp3r1 | 6.70e-01 | 0.0e+00 | 9.00e-02 | 8.8e-01 | 2.10e-01 | 6.9e-01 | 2.20e-01 | 5.8e-01 | 2.20e-01 | 5.5e-01 | 2.30e-01 | 1.8e-01 |
| 10 | Adcyap1r1 | 9.00e-01 | 0.0e+00 | 3.00e-02 | 9.3e-01 | 4.40e-01 | 0.0e+00 | 1.53e+00 | 0.0e+00 | 8.30e-01 | 0.0e+00 | 2.40e-01 | 2.4e-01 |
| 13 | Adora1 | 1.68e+00 | 0.0e+00 | 6.20e-01 | 0.0e+00 | 5.90e-01 | 4.0e-02 | -2.20e-01 | 6.3e-01 | 9.40e-01 | 0.0e+00 | 2.50e-01 | 4.6e-01 |
| 205 | Pak1 | 1.90e-01 | 3.6e-01 | 1.00e-01 | 8.0e-01 | -1.13e+00 | 0.0e+00 | -6.00e-02 | 9.1e-01 | 1.50e-01 | 8.5e-01 | 3.00e-01 | 2.0e-01 |
| 236 | Prkacb | 1.10e-01 | 6.6e-01 | -5.00e-02 | 9.2e-01 | 9.30e-01 | 0.0e+00 | 1.90e-01 | 7.9e-01 | 2.30e-01 | 5.8e-01 | 3.00e-01 | 7.0e-02 |
| 225 | Plcb3 | -5.00e-02 | 7.9e-01 | 1.10e-01 | 8.5e-01 | -7.30e-01 | 1.0e-02 | -3.50e-01 | 2.5e-01 | -3.80e-01 | 7.0e-02 | 3.10e-01 | 1.3e-01 |
| 98 | Ece1 | 9.30e-01 | 0.0e+00 | 2.50e-01 | 1.2e-01 | 1.10e-01 | 3.1e-01 | 5.70e-01 | 0.0e+00 | 6.90e-01 | 0.0e+00 | 3.40e-01 | 2.0e-02 |
| 175 | Ihh | -5.00e-01 | 2.1e-01 | 1.10e-01 | NA | -4.60e-01 | NA | -7.50e-01 | 1.0e-02 | -1.90e-01 | NA | 3.70e-01 | NA |
| 312 | Xcl1 | -7.60e-01 | 7.0e-02 | NA | NA | -3.00e-02 | NA | -2.50e-01 | NA | -1.20e-01 | NA | 3.80e-01 | NA |
| 273 | Rhob | 9.00e-02 | 7.2e-01 | 4.50e-01 | 0.0e+00 | -5.00e-02 | 8.6e-01 | 6.30e-01 | 0.0e+00 | 4.20e-01 | 0.0e+00 | 3.80e-01 | 2.0e-01 |
| 9 | Adcy9 | -5.00e-02 | 8.6e-01 | -1.50e-01 | 6.9e-01 | -2.10e-01 | 5.8e-01 | -6.70e-01 | 0.0e+00 | -4.30e-01 | 4.0e-02 | 4.40e-01 | 4.0e-02 |
| 93 | Dagla | -2.90e-01 | 2.0e-02 | -1.20e-01 | 6.4e-01 | -4.30e-01 | 2.8e-01 | -5.70e-01 | 2.3e-01 | -1.37e+00 | 0.0e+00 | 4.40e-01 | 6.0e-02 |
| 17 | Adra1b | 5.30e-01 | 1.0e-02 | 2.30e-01 | 5.9e-01 | 6.70e-01 | 1.4e-01 | -8.80e-01 | 0.0e+00 | 6.40e-01 | 2.3e-01 | 4.50e-01 | 5.5e-01 |
| 228 | Ppp1r1b | 9.80e-01 | 0.0e+00 | 5.70e-01 | 3.0e-02 | -2.70e-01 | 6.8e-01 | 3.40e-01 | 6.5e-01 | 9.00e-02 | NA | 4.70e-01 | 5.5e-01 |
| 152 | Gpr37 | -7.80e-01 | 0.0e+00 | -1.60e-01 | 5.6e-01 | -4.80e-01 | 4.8e-01 | -7.30e-01 | 9.0e-02 | 2.90e-01 | 6.7e-01 | 4.90e-01 | 3.6e-01 |
| 60 | Ccl5 | -2.40e-01 | 2.0e-01 | 3.20e-01 | 4.9e-01 | 7.40e-01 | 4.0e-02 | -3.80e-01 | 4.7e-01 | -3.90e-01 | 2.5e-01 | 5.30e-01 | 3.3e-01 |
| 299 | Vip | 0.00e+00 | 1.0e+00 | 3.70e-01 | 4.1e-01 | 0.00e+00 | 1.0e+00 | 6.00e-02 | NA | 9.90e-01 | 3.0e-02 | 5.60e-01 | NA |
| 178 | Itsn1 | -3.30e-01 | 7.0e-02 | -3.00e-01 | 4.2e-01 | -3.00e-02 | 9.3e-01 | -7.30e-01 | 0.0e+00 | -6.80e-01 | 0.0e+00 | 5.70e-01 | 0.0e+00 |
| 95 | Dgke | 1.10e-01 | 7.5e-01 | 5.00e-02 | 9.5e-01 | 2.70e-01 | 4.6e-01 | 4.60e-01 | 3.4e-01 | 7.50e-01 | 1.0e-02 | 5.80e-01 | 0.0e+00 |
| 2 | Abr | 3.90e-01 | 0.0e+00 | 1.10e-01 | 6.6e-01 | 0.00e+00 | 1.0e+00 | 5.00e-02 | 9.6e-01 | 1.70e-01 | 5.5e-01 | 5.90e-01 | 0.0e+00 |
| 51 | Camk2d | 1.00e-02 | 9.7e-01 | -4.00e-02 | 9.5e-01 | -5.70e-01 | 4.0e-02 | -2.10e-01 | 7.8e-01 | 1.00e-02 | 9.9e-01 | 5.90e-01 | 1.0e-02 |
| 196 | Obscn | -6.20e-01 | 1.3e-01 | -4.00e-02 | 9.6e-01 | 1.50e-01 | 8.0e-01 | -2.10e-01 | 7.9e-01 | -4.60e-01 | 3.3e-01 | 6.00e-01 | 1.0e-02 |
| 232 | Ppp3ca | -2.30e-01 | 3.5e-01 | 0.00e+00 | 1.0e+00 | -2.60e-01 | 2.0e-01 | -9.00e-02 | 8.9e-01 | -4.40e-01 | 6.0e-02 | 6.10e-01 | 0.0e+00 |
| 14 | Adora2a | -8.50e-01 | 0.0e+00 | 1.50e-01 | 8.3e-01 | 1.60e-01 | 7.3e-01 | -1.60e-01 | 8.1e-01 | 5.60e-01 | 8.0e-02 | 6.20e-01 | 1.0e-02 |
| 149 | Gpr17 | -6.00e-02 | 9.2e-01 | 1.50e-01 | 7.4e-01 | 5.00e-02 | NA | 8.00e-02 | NA | 9.70e-01 | 3.0e-02 | 6.40e-01 | 3.7e-01 |
| 240 | Prkce | -3.00e-02 | 9.3e-01 | 0.00e+00 | 1.0e+00 | 5.30e-01 | 7.0e-02 | 3.80e-01 | 3.1e-01 | -1.20e-01 | 7.6e-01 | 6.70e-01 | 0.0e+00 |
| 243 | Prkcq | -3.80e-01 | 1.3e-01 | -4.00e-02 | 9.3e-01 | -1.80e-01 | 7.1e-01 | 7.00e-02 | 9.6e-01 | -4.50e-01 | 3.5e-01 | 6.70e-01 | 0.0e+00 |
| 36 | Arhgef37 | -2.50e-01 | 5.0e-01 | -9.00e-02 | 8.5e-01 | -4.00e-01 | 1.9e-01 | -6.40e-01 | 2.0e-02 | 2.00e-02 | 9.6e-01 | 7.00e-01 | 0.0e+00 |
| 129 | Gna13 | 3.10e-01 | 1.3e-01 | 1.80e-01 | 6.4e-01 | 4.30e-01 | 1.0e-02 | 3.70e-01 | 2.4e-01 | 2.70e-01 | 3.6e-01 | 7.20e-01 | 0.0e+00 |
| 136 | Gnas | -1.10e-01 | 7.4e-01 | 2.80e-01 | 1.1e-01 | 3.00e-01 | 3.4e-01 | 5.00e-02 | 9.4e-01 | 4.00e-02 | 9.3e-01 | 7.50e-01 | 0.0e+00 |
| 142 | Gnb5 | -6.00e-02 | 8.9e-01 | 2.10e-01 | 3.8e-01 | -5.00e-02 | 9.1e-01 | 5.00e-01 | 1.0e-01 | -1.00e-02 | 9.9e-01 | 7.60e-01 | 0.0e+00 |
| 192 | Nmb | 4.00e-01 | NA | 3.20e-01 | 5.1e-01 | 1.85e+00 | 0.0e+00 | 1.40e-01 | NA | 5.20e-01 | NA | 7.70e-01 | 2.3e-01 |
| 250 | Ptger1 | 1.01e+00 | 0.0e+00 | 3.50e-01 | 3.6e-01 | 0.00e+00 | 1.0e+00 | 4.50e-01 | 3.2e-01 | 1.05e+00 | 0.0e+00 | 8.10e-01 | 0.0e+00 |
| 211 | Pde4a | -7.80e-01 | 0.0e+00 | -2.40e-01 | 3.0e-01 | -8.30e-01 | 1.0e-02 | 1.40e-01 | 8.6e-01 | -7.20e-01 | 0.0e+00 | 8.40e-01 | 0.0e+00 |
| 128 | Glp2r | 1.01e+00 | 0.0e+00 | 1.00e-01 | 9.0e-01 | -4.00e-02 | NA | 6.00e-02 | NA | 9.60e-01 | 4.0e-02 | 8.50e-01 | NA |
| 123 | Gcgr | -3.80e-01 | 4.0e-01 | 2.00e-02 | NA | -6.00e-02 | 9.2e-01 | -1.50e-01 | 6.1e-01 | 5.20e-01 | 2.8e-01 | 8.70e-01 | 1.0e-01 |
| 163 | Hcrtr1 | 1.17e+00 | 0.0e+00 | 2.00e-01 | 6.0e-01 | 1.44e+00 | 0.0e+00 | 7.00e-02 | NA | 3.20e-01 | 6.4e-01 | 8.70e-01 | 2.2e-01 |
| 135 | Gnal | -3.20e-01 | 3.8e-01 | 5.00e-02 | 9.3e-01 | 3.70e-01 | 3.5e-01 | -4.00e-02 | 9.7e-01 | -1.00e-02 | 9.8e-01 | 8.80e-01 | 0.0e+00 |
| 306 | Wnt4 | 5.50e-01 | 0.0e+00 | -1.00e-02 | 9.9e-01 | -2.50e-01 | 3.6e-01 | 1.88e+00 | 0.0e+00 | -4.30e-01 | 4.8e-01 | 8.90e-01 | 0.0e+00 |
| 111 | Fgd4 | 2.30e-01 | 6.1e-01 | -1.00e-01 | 9.0e-01 | -2.20e-01 | 7.7e-01 | -8.00e-02 | 9.4e-01 | 1.85e+00 | 0.0e+00 | 9.40e-01 | 0.0e+00 |
| 249 | Ptgdr2 | -2.20e-01 | 6.3e-01 | 2.00e-02 | NA | -6.10e-01 | 5.0e-02 | 6.30e-01 | NA | -2.00e-02 | NA | 9.50e-01 | 1.8e-01 |
| 197 | Opn4 | 9.30e-01 | 1.0e-02 | 2.00e-02 | 9.8e-01 | 1.80e-01 | 8.3e-01 | -1.00e-01 | NA | 3.00e-01 | 6.6e-01 | 1.04e+00 | 1.0e-02 |
| 190 | Net1 | 3.70e-01 | 0.0e+00 | -1.00e-02 | 9.9e-01 | 1.03e+00 | 0.0e+00 | -1.11e+00 | 0.0e+00 | 4.40e-01 | 1.9e-01 | 1.05e+00 | 0.0e+00 |
| 290 | Tiam2 | -3.80e-01 | 1.0e-02 | 7.00e-02 | 8.6e-01 | 9.50e-01 | 0.0e+00 | 3.30e-01 | 5.2e-01 | 1.40e-01 | 7.5e-01 | 1.07e+00 | 0.0e+00 |
| 259 | Rasgrp2 | -2.50e-01 | 1.3e-01 | 1.00e-02 | 9.9e-01 | -2.80e-01 | 4.7e-01 | -4.90e-01 | 2.0e-02 | -3.70e-01 | 2.1e-01 | 1.08e+00 | 0.0e+00 |
| 41 | Avpr2 | 2.40e-01 | 6.3e-01 | -3.20e-01 | 5.0e-01 | 1.06e+00 | 6.0e-02 | 0.00e+00 | NA | 7.50e-01 | NA | 1.09e+00 | NA |
| 50 | Camk2a | -2.20e-01 | 5.8e-01 | 1.90e-01 | 6.0e-01 | -3.00e-01 | 7.0e-01 | -1.00e-01 | NA | -6.20e-01 | 2.2e-01 | 1.13e+00 | 0.0e+00 |
| 276 | Rrh | 2.00e-01 | 7.2e-01 | 3.10e-01 | 5.3e-01 | 1.57e+00 | 0.0e+00 | 2.40e-01 | NA | -1.70e-01 | NA | 1.16e+00 | 9.0e-02 |
| 187 | Mc4r | -2.00e-01 | NA | -3.30e-01 | 3.8e-01 | 1.50e-01 | NA | NA | NA | 1.70e-01 | NA | 1.17e+00 | 6.0e-02 |
| 310 | Wnt9a | 4.30e-01 | 3.4e-01 | -3.00e-02 | NA | 8.80e-01 | 1.3e-01 | -4.00e-02 | NA | -3.60e-01 | 5.8e-01 | 1.18e+00 | 0.0e+00 |
| 288 | Tas1r3 | -2.80e-01 | 5.9e-01 | 1.30e-01 | NA | 9.20e-01 | 8.0e-02 | 3.70e-01 | NA | 1.60e-01 | 8.4e-01 | 1.25e+00 | 5.0e-02 |
| 278 | Rxfp2 | -1.50e-01 | 8.1e-01 | 1.50e-01 | 8.2e-01 | -9.00e-02 | NA | NA | NA | 5.20e-01 | 3.4e-01 | 1.25e+00 | 7.0e-02 |
| 219 | Pik3r1 | 1.10e-01 | 7.6e-01 | 1.00e-01 | 8.6e-01 | -7.00e-02 | 8.4e-01 | 5.90e-01 | 0.0e+00 | 3.70e-01 | 9.0e-02 | 1.27e+00 | 0.0e+00 |
| 296 | Ucn2 | -5.00e-02 | 9.4e-01 | 1.00e-01 | NA | 5.20e-01 | 2.8e-01 | NA | NA | 4.00e-02 | NA | 1.36e+00 | 2.0e-02 |
| 194 | Npffr1 | -2.00e-02 | NA | -1.00e-01 | 8.7e-01 | 4.90e-01 | NA | -2.00e-02 | NA | 1.80e-01 | NA | 1.42e+00 | 2.0e-02 |
| 91 | Cxcr5 | -2.80e-01 | 5.7e-01 | 2.20e-01 | NA | 3.40e-01 | 6.5e-01 | 1.00e-02 | 9.9e-01 | 3.80e-01 | 3.1e-01 | 1.42e+00 | 0.0e+00 |
| 166 | Hras | 1.30e-01 | 6.7e-01 | 3.90e-01 | 2.0e-01 | 1.10e-01 | 8.3e-01 | 2.10e-01 | 6.9e-01 | -2.00e-02 | 9.6e-01 | 1.46e+00 | 0.0e+00 |
| 214 | Pde4d | 2.10e-01 | 6.0e-01 | -1.60e-01 | 7.9e-01 | 7.20e-01 | 3.0e-02 | -5.10e-01 | 2.5e-01 | 8.60e-01 | 3.0e-02 | 1.70e+00 | 0.0e+00 |
| 266 | Rgs20 | -1.30e-01 | 8.1e-01 | -1.70e-01 | 6.5e-01 | 6.80e-01 | 2.6e-01 | 9.00e-02 | NA | 1.34e+00 | 0.0e+00 | 1.85e+00 | 0.0e+00 |
| 295 | Ucn | 4.00e-02 | NA | -1.80e-01 | NA | 3.00e-02 | NA | NA | NA | -3.00e-02 | NA | 2.56e+00 | 0.0e+00 |
| 72 | Chrm2 | -1.14e+00 | 0.0e+00 | -4.00e-01 | 3.5e-01 | 6.00e-02 | 9.5e-01 | -6.90e-01 | NA | NA | NA | NA | NA |
| 87 | Cxcl3 | 1.20e-01 | 6.3e-01 | -5.30e-01 | 1.0e-01 | 9.30e-01 | 2.0e-02 | -1.80e-01 | NA | 4.00e-02 | NA | NA | NA |
| 147 | Gnrhr | 5.00e-02 | NA | -4.00e-02 | NA | -6.30e-01 | 9.0e-02 | -2.00e-02 | NA | -4.00e-02 | NA | NA | NA |
| 174 | Iapp | 7.50e-01 | 2.0e-02 | -2.00e-02 | NA | 4.00e-02 | NA | 3.00e-02 | NA | NA | NA | NA | NA |
| 193 | Nmu | 4.00e-02 | NA | 4.00e-01 | 3.6e-01 | 1.19e+00 | 2.0e-02 | 0.00e+00 | NA | -2.00e-02 | NA | NA | NA |
| 245 | Prlhr | 0.00e+00 | NA | 5.90e-01 | 6.0e-02 | 2.70e-01 | 7.3e-01 | NA | NA | -1.00e-02 | NA | NA | NA |
| 309 | Wnt7a | -8.10e-01 | 0.0e+00 | -6.90e-01 | 0.0e+00 | 2.40e-01 | 6.9e-01 | -2.80e-01 | 7.3e-01 | -1.00e-02 | NA | NA | NA |
GPCR %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S17. Relative changes in the expression of genes involved in GPCR signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))Adreno%>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>%kable(caption = "Supplementary Table 18. Relative changes in the expression of genes involved in Adrenoreceptor signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(Adreno$Adrenal_padj),F,ifelse(Adreno$Adrenal_padj<.1,T,F)),color= ifelse(is.na(Adreno$Adrenal_padj),"gray",ifelse(Adreno$Adrenal_padj<.1,spec_color(Adreno$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(Adreno$HT_padj),F,ifelse(Adreno$HT_padj<.1,T,F)),color= ifelse(is.na(Adreno$HT_padj),"gray",ifelse(Adreno$HT_padj<.1,spec_color(Adreno$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(Adreno$Liver_padj),F,ifelse(Adreno$Liver_padj<.1,T,F)),color= ifelse(is.na(Adreno$Liver_padj),"gray",ifelse(Adreno$Liver_padj<.1,spec_color(Adreno$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(Adreno$Lung_padj),F,ifelse(Adreno$Lung_padj<.1,T,F)),color= ifelse(is.na(Adreno$Lung_padj),"gray",ifelse(Adreno$Lung_padj <.1,spec_color(Adreno$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(Adreno$Adipose_padj),F,ifelse(Adreno$Adipose_padj<.1,T,F)),color= ifelse(is.na(Adreno$Adipose_padj),"gray",ifelse(Adreno$Adipose_padj<.1, spec_color(Adreno$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(Adreno$Muscle_padj),F,ifelse(Adreno$Muscle_padj<.1,T,F)),color= ifelse(is.na(Adreno$Muscle_padj),"gray",ifelse(Adreno$Muscle_padj<.1,spec_color(Adreno$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | Adrb2 | 3.5e-01 | 7.0e-02 | -2.3e-01 | 6.3e-01 | 0.00e+00 | 1.0e+00 | -2.1e-01 | 7.8e-01 | 1.90e-01 | 6.3e-01 | -2.23e+00 | 0.0e+00 |
| 4 | Adra2a | -2.8e-01 | 4.5e-01 | -4.6e-01 | 1.0e-02 | 4.70e-01 | 1.6e-01 | -7.0e-02 | NA | -2.50e-01 | 7.0e-01 | -1.94e+00 | 0.0e+00 |
| 6 | Adrb3 | -2.6e-01 | 6.0e-02 | -1.0e-01 | NA | -2.58e+00 | 0.0e+00 | -2.8e-01 | NA | -2.51e+00 | 0.0e+00 | -7.80e-01 | 2.2e-01 |
| 3 | Adra1d | -9.2e-01 | 0.0e+00 | 2.6e-01 | 6.1e-01 | 8.90e-01 | 2.0e-02 | 2.9e-01 | NA | -1.92e+00 | 0.0e+00 | -1.80e-01 | 6.9e-01 |
| 1 | Adra1a | -9.8e-01 | 0.0e+00 | -1.3e-01 | 8.6e-01 | -7.90e-01 | 1.7e-01 | -9.0e-02 | NA | -1.24e+00 | 0.0e+00 | -1.00e-02 | 9.9e-01 |
| 2 | Adra1b | 5.3e-01 | 1.0e-02 | 2.3e-01 | 5.9e-01 | 6.70e-01 | 1.4e-01 | -8.8e-01 | 0.0e+00 | 6.40e-01 | 2.3e-01 | 4.50e-01 | 5.5e-01 |
Adreno %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S18. Relative changes in the expression of genes involved in Adrenoreceptor signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))GR_signaling%>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>%kable(caption = "Supplementary Table 19. Relative changes in the expression of genes involved in GR signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(GR_signaling$Adrenal_padj),F,ifelse(GR_signaling$Adrenal_padj<.1,T,F)),color= ifelse(is.na(GR_signaling$Adrenal_padj),"gray",ifelse(GR_signaling$Adrenal_padj<.1,spec_color(GR_signaling$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(GR_signaling$HT_padj),F,ifelse(GR_signaling$HT_padj<.1,T,F)),color= ifelse(is.na(GR_signaling$HT_padj),"gray",ifelse(GR_signaling$HT_padj<.1,spec_color(GR_signaling$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(GR_signaling$Liver_padj),F,ifelse(GR_signaling$Liver_padj<.1,T,F)),color= ifelse(is.na(GR_signaling$Liver_padj),"gray",ifelse(GR_signaling$Liver_padj<.1,spec_color(GR_signaling$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(GR_signaling$Lung_padj),F,ifelse(GR_signaling$Lung_padj<.1,T,F)),color= ifelse(is.na(GR_signaling$Lung_padj),"gray",ifelse(GR_signaling$Lung_padj <.1,spec_color(GR_signaling$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(GR_signaling$Adipose_padj),F,ifelse(GR_signaling$Adipose_padj<.1,T,F)),color= ifelse(is.na(GR_signaling$Adipose_padj),"gray",ifelse(GR_signaling$Adipose_padj<.1, spec_color(GR_signaling$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(GR_signaling$Muscle_padj),F,ifelse(GR_signaling$Muscle_padj<.1,T,F)),color= ifelse(is.na(GR_signaling$Muscle_padj),"gray",ifelse(GR_signaling$Muscle_padj<.1,spec_color(GR_signaling$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | B3gnt5 | -7.70e-01 | 3.0e-02 | -2.90e-01 | NA | 1.00e-01 | NA | -1.70e-01 | NA | 6.60e-01 | 1.5e-01 | -1.97e+00 | 0.0e+00 |
| 9 | Ccl2 | 8.60e-01 | 2.0e-02 | -5.00e-02 | NA | -5.90e-01 | 3.0e-01 | -3.00e-02 | 9.9e-01 | -4.40e-01 | 4.6e-01 | -1.93e+00 | 0.0e+00 |
| 37 | Snai2 | -5.50e-01 | 4.0e-02 | -2.40e-01 | 6.6e-01 | -1.50e-01 | 8.3e-01 | 6.00e-02 | 9.6e-01 | -2.90e-01 | 5.9e-01 | -1.84e+00 | 0.0e+00 |
| 18 | Hsp90aa1 | 9.00e-02 | 8.8e-01 | 1.40e-01 | 8.0e-01 | 1.60e-01 | NA | -2.60e-01 | 7.3e-01 | 5.00e-01 | 3.0e-01 | -1.77e+00 | 0.0e+00 |
| 31 | Rgs2 | -1.80e-01 | 2.7e-01 | 1.00e-01 | 7.8e-01 | -7.00e-01 | 1.6e-01 | 3.00e-02 | 9.8e-01 | -1.00e-01 | 8.8e-01 | -1.76e+00 | 0.0e+00 |
| 41 | Thbd | -3.00e-02 | 8.9e-01 | -5.80e-01 | 1.1e-01 | 1.06e+00 | 0.0e+00 | -1.70e-01 | 8.7e-01 | -1.20e-01 | 8.5e-01 | -1.71e+00 | 0.0e+00 |
| 6 | Bhlhe40 | 7.20e-01 | 0.0e+00 | 2.00e-01 | 5.5e-01 | 9.50e-01 | 0.0e+00 | -1.07e+00 | 0.0e+00 | -7.90e-01 | 1.0e-02 | -1.60e+00 | 0.0e+00 |
| 4 | Ankrd1 | -7.10e-01 | 2.0e-02 | 2.00e-02 | NA | 3.40e-01 | 6.3e-01 | -4.60e-01 | 4.7e-01 | 1.00e-02 | 9.9e-01 | -1.57e+00 | 1.0e-02 |
| 29 | Prrg4 | 7.00e-02 | 9.0e-01 | -1.30e-01 | NA | 3.50e-01 | 6.2e-01 | -8.30e-01 | 6.0e-02 | -1.30e-01 | 8.7e-01 | -1.51e+00 | 2.0e-02 |
| 30 | Ptgs2 | 9.50e-01 | 0.0e+00 | -3.40e-01 | 2.8e-01 | 4.20e-01 | 3.8e-01 | -2.60e-01 | 7.7e-01 | 4.00e-01 | 5.2e-01 | -1.49e+00 | 0.0e+00 |
| 2 | Amigo2 | 7.00e-02 | 8.1e-01 | 0.00e+00 | 1.0e+00 | -3.10e-01 | 2.4e-01 | -4.40e-01 | 2.0e-02 | -6.10e-01 | 1.8e-01 | -1.47e+00 | 0.0e+00 |
| 34 | Serpinb9 | -4.90e-01 | 0.0e+00 | -2.90e-01 | 7.0e-02 | -3.40e-01 | 1.3e-01 | -7.40e-01 | 0.0e+00 | -3.50e-01 | 2.3e-01 | -1.37e+00 | 0.0e+00 |
| 28 | Pmp2 | 2.20e-01 | NA | 3.00e-01 | 5.2e-01 | -1.50e-01 | NA | NA | NA | 2.80e-01 | NA | -1.30e+00 | 3.0e-02 |
| 12 | Epb41l4b | 3.60e-01 | 0.0e+00 | 7.00e-02 | 8.8e-01 | 3.80e-01 | 2.5e-01 | -2.70e-01 | 2.0e-02 | -1.00e-01 | 7.6e-01 | -1.21e+00 | 0.0e+00 |
| 27 | Plk2 | 2.60e-01 | 1.6e-01 | 1.00e-02 | 9.9e-01 | 1.90e-01 | 5.1e-01 | -4.90e-01 | 0.0e+00 | -6.30e-01 | 2.0e-02 | -1.14e+00 | 0.0e+00 |
| 11 | Enc1 | 1.04e+00 | 0.0e+00 | -1.00e-02 | 9.9e-01 | -5.50e-01 | 2.0e-02 | 1.05e+00 | 0.0e+00 | 2.60e-01 | 5.4e-01 | -9.10e-01 | 6.0e-02 |
| 1 | Ackr3 | 4.10e-01 | 0.0e+00 | 0.00e+00 | 1.0e+00 | 6.90e-01 | 0.0e+00 | -2.50e-01 | 7.5e-01 | 7.00e-02 | 9.2e-01 | -8.40e-01 | 0.0e+00 |
| 22 | Nav3 | -4.90e-01 | 1.3e-01 | -1.60e-01 | 7.9e-01 | -1.24e+00 | 0.0e+00 | -3.20e-01 | 6.2e-01 | 6.00e-01 | 1.4e-01 | -7.70e-01 | 4.0e-02 |
| 35 | Slc19a2 | 3.60e-01 | 0.0e+00 | -1.90e-01 | 3.7e-01 | 1.70e-01 | 3.9e-01 | -1.00e+00 | 0.0e+00 | -6.00e-02 | 8.8e-01 | -6.20e-01 | 3.0e-02 |
| 10 | Cdc42ep3 | -4.00e-01 | 0.0e+00 | -1.20e-01 | 8.4e-01 | -6.10e-01 | 7.0e-02 | -2.00e-01 | 6.8e-01 | -4.50e-01 | 1.9e-01 | -6.00e-01 | 0.0e+00 |
| 25 | Nr3c1 | -4.40e-01 | 3.0e-02 | -3.70e-01 | 2.3e-01 | -2.70e-01 | 5.3e-01 | -8.10e-01 | 0.0e+00 | -7.30e-01 | 1.0e-02 | -5.50e-01 | 1.0e-02 |
| 19 | Jun | 4.20e-01 | 6.0e-02 | -3.60e-01 | 2.2e-01 | -7.30e-01 | 0.0e+00 | -9.30e-01 | 2.0e-02 | 6.40e-01 | 8.0e-02 | -5.30e-01 | 2.0e-02 |
| 36 | Slc26a2 | -3.50e-01 | 3.2e-01 | -7.20e-01 | 2.0e-02 | -2.40e-01 | 6.0e-01 | -3.20e-01 | 6.7e-01 | 5.00e-02 | 9.4e-01 | -4.90e-01 | 1.9e-01 |
| 13 | Etnk2 | 3.00e-02 | 9.6e-01 | 0.00e+00 | 1.0e+00 | -1.09e+00 | 0.0e+00 | 1.60e-01 | 7.5e-01 | 8.00e-02 | 9.3e-01 | -3.50e-01 | 6.7e-01 |
| 42 | Tnfaip3 | 2.10e-01 | 5.3e-01 | -2.20e-01 | 6.7e-01 | -2.70e-01 | 4.6e-01 | 7.90e-01 | 2.0e-02 | -3.30e-01 | 4.4e-01 | -3.00e-01 | 4.5e-01 |
| 33 | Scnn1a | 5.30e-01 | 0.0e+00 | -3.00e-01 | 4.7e-01 | 7.60e-01 | 1.0e-01 | -6.10e-01 | 1.5e-01 | -3.00e-01 | 5.4e-01 | -2.80e-01 | 6.2e-01 |
| 7 | Birc2 | 2.00e-01 | 8.0e-02 | 1.00e-01 | 8.0e-01 | -9.20e-01 | 0.0e+00 | -8.10e-01 | 0.0e+00 | 2.00e-01 | 3.0e-01 | -1.50e-01 | 4.1e-01 |
| 40 | Tgfbr3 | 8.20e-01 | 0.0e+00 | -1.50e-01 | 8.0e-01 | -6.80e-01 | 0.0e+00 | 1.90e-01 | 6.8e-01 | 4.00e-01 | 1.0e-02 | -1.00e-01 | 7.4e-01 |
| 21 | Mgam | -1.36e+00 | 0.0e+00 | -4.50e-01 | 2.7e-01 | -6.90e-01 | 2.1e-01 | -2.30e-01 | 7.2e-01 | NA | NA | -9.00e-02 | NA |
| 43 | Tns4 | -6.80e-01 | 1.0e-01 | -2.00e-02 | NA | 0.00e+00 | NA | 1.70e-01 | NA | -4.70e-01 | 2.3e-01 | -3.00e-02 | NA |
| 24 | Nr1i2 | -6.10e-01 | 1.5e-01 | 1.50e-01 | 7.9e-01 | -8.50e-01 | 1.3e-01 | 1.16e+00 | 0.0e+00 | -1.10e-01 | NA | -3.00e-02 | NA |
| 39 | Stom | 5.60e-01 | 0.0e+00 | 1.60e-01 | 6.2e-01 | 3.30e-01 | 0.0e+00 | 7.50e-01 | 0.0e+00 | 1.70e-01 | 5.0e-01 | 1.00e-01 | 7.3e-01 |
| 3 | Angptl4 | 4.90e-01 | 2.1e-01 | 2.40e-01 | 5.6e-01 | 7.80e-01 | 0.0e+00 | 3.00e-01 | 1.4e-01 | 1.10e-01 | 8.1e-01 | 1.20e-01 | 7.7e-01 |
| 15 | Fgfbp1 | -9.10e-01 | 0.0e+00 | -6.00e-02 | NA | 1.90e-01 | NA | -1.90e-01 | NA | -5.90e-01 | NA | 1.50e-01 | NA |
| 38 | Spry1 | 5.90e-01 | 0.0e+00 | 4.80e-01 | 2.0e-02 | 4.40e-01 | 0.0e+00 | -2.00e-02 | 9.9e-01 | 3.70e-01 | 2.5e-01 | 1.60e-01 | 3.8e-01 |
| 26 | Pde4b | 4.00e-01 | 7.0e-02 | -3.00e-02 | 9.5e-01 | 1.32e+00 | 0.0e+00 | 1.00e-01 | 9.2e-01 | -9.00e-02 | 8.6e-01 | 1.80e-01 | 6.1e-01 |
| 23 | Nfkb2 | 2.60e-01 | 1.7e-01 | -4.70e-01 | 1.5e-01 | -1.90e-01 | 5.9e-01 | -8.00e-02 | 8.6e-01 | -7.60e-01 | 0.0e+00 | 2.10e-01 | 2.5e-01 |
| 20 | Lrrc8a | 2.90e-01 | 0.0e+00 | 2.10e-01 | 3.9e-01 | 9.00e-02 | 7.9e-01 | 6.60e-01 | 0.0e+00 | 5.20e-01 | 2.0e-02 | 2.90e-01 | 1.4e-01 |
| 44 | Tsc22d3 | 9.30e-01 | 0.0e+00 | 5.40e-01 | 2.0e-02 | -4.60e-01 | 6.0e-02 | 8.50e-01 | 0.0e+00 | 1.11e+00 | 0.0e+00 | 4.50e-01 | 6.0e-02 |
| 8 | Birc3 | 2.20e-01 | 5.0e-01 | 1.10e-01 | 8.8e-01 | 4.70e-01 | 1.8e-01 | 7.50e-01 | 0.0e+00 | 6.50e-01 | 1.0e-02 | 7.70e-01 | 1.0e-02 |
| 32 | Rxra | 4.00e-02 | 7.9e-01 | 7.00e-02 | 8.8e-01 | -1.10e-01 | 7.6e-01 | 3.90e-01 | 4.0e-02 | 7.00e-02 | 8.5e-01 | 8.90e-01 | 0.0e+00 |
| 14 | Fgd4 | 2.30e-01 | 6.1e-01 | -1.00e-01 | 9.0e-01 | -2.20e-01 | 7.7e-01 | -8.00e-02 | 9.4e-01 | 1.85e+00 | 0.0e+00 | 9.40e-01 | 0.0e+00 |
| 17 | Gadd45b | 6.30e-01 | 0.0e+00 | 1.80e-01 | 7.8e-01 | 9.00e-01 | 3.0e-02 | 1.58e+00 | 0.0e+00 | 3.90e-01 | 5.3e-01 | 1.75e+00 | 0.0e+00 |
| 16 | Fkbp5 | 1.96e+00 | 0.0e+00 | 1.47e+00 | 0.0e+00 | 5.70e-01 | 0.0e+00 | 2.55e+00 | 0.0e+00 | 1.40e+00 | 0.0e+00 | 2.30e+00 | 0.0e+00 |
GR_signaling %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S19. Relative changes in the expression of genes involved in GR signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))AR%>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>%kable(caption = "Supplementary Table 20. Relative changes in the expression of genes involved in androgen receptor signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(AR$Adrenal_padj),F,ifelse(AR$Adrenal_padj<.1,T,F)),color= ifelse(is.na(AR$Adrenal_padj),"gray",ifelse(AR$Adrenal_padj<.1,spec_color(AR$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(AR$HT_padj),F,ifelse(AR$HT_padj<.1,T,F)),color= ifelse(is.na(AR$HT_padj),"gray",ifelse(AR$HT_padj<.1,spec_color(AR$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(AR$Liver_padj),F,ifelse(AR$Liver_padj<.1,T,F)),color= ifelse(is.na(AR$Liver_padj),"gray",ifelse(AR$Liver_padj<.1,spec_color(AR$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(AR$Lung_padj),F,ifelse(AR$Lung_padj<.1,T,F)),color= ifelse(is.na(AR$Lung_padj),"gray",ifelse(AR$Lung_padj <.1,spec_color(AR$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(AR$Adipose_padj),F,ifelse(AR$Adipose_padj<.1,T,F)),color= ifelse(is.na(AR$Adipose_padj),"gray",ifelse(AR$Adipose_padj<.1, spec_color(AR$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(AR$Muscle_padj),F,ifelse(AR$Muscle_padj<.1,T,F)),color= ifelse(is.na(AR$Muscle_padj),"gray",ifelse(AR$Muscle_padj<.1,spec_color(AR$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 13 | Ccnd1 | -5.70e-01 | 0.0e+00 | -8.80e-01 | 0.0e+00 | -7.20e-01 | 0.0e+00 | -1.03e+00 | 0.0e+00 | -8.20e-01 | 0.0e+00 | -2.57e+00 | 0.0e+00 |
| 41 | Pmepa1 | 2.60e-01 | 2.0e-01 | 4.00e-02 | 9.6e-01 | 7.00e-01 | 7.0e-02 | 3.80e-01 | 5.1e-01 | 5.60e-01 | 5.0e-02 | -2.07e+00 | 0.0e+00 |
| 6 | Aldh1a3 | -3.40e-01 | 3.0e-02 | -3.00e-01 | 5.4e-01 | 1.70e-01 | 4.9e-01 | 1.40e-01 | 7.3e-01 | -8.70e-01 | 0.0e+00 | -1.82e+00 | 0.0e+00 |
| 32 | Krt19 | 2.50e-01 | 2.7e-01 | -3.70e-01 | 4.1e-01 | 7.60e-01 | 1.7e-01 | 2.80e-01 | 7.4e-01 | -4.00e-02 | 9.5e-01 | -1.49e+00 | 3.0e-02 |
| 28 | Inpp4b | -3.00e-02 | 9.6e-01 | -1.90e-01 | 6.4e-01 | -8.50e-01 | 1.0e-02 | -4.80e-01 | 3.4e-01 | -6.50e-01 | 6.0e-02 | -1.40e+00 | 0.0e+00 |
| 52 | Tmprss2 | -4.40e-01 | 0.0e+00 | -4.20e-01 | 3.3e-01 | -2.00e-02 | 9.9e-01 | -3.60e-01 | 3.1e-01 | -1.39e+00 | 0.0e+00 | -1.38e+00 | 5.0e-02 |
| 26 | Homer2 | -3.60e-01 | 1.6e-01 | 1.10e-01 | 8.7e-01 | -2.60e-01 | 5.0e-01 | -9.00e-02 | 8.8e-01 | 1.90e-01 | 6.4e-01 | -1.28e+00 | 0.0e+00 |
| 36 | Myl12a | 2.00e-02 | 8.8e-01 | -1.20e-01 | 8.4e-01 | 1.20e-01 | 2.9e-01 | 4.00e-02 | 9.3e-01 | 3.40e-01 | 5.0e-02 | -1.25e+00 | 0.0e+00 |
| 9 | Arid5b | 8.00e-02 | 8.6e-01 | -3.20e-01 | 4.7e-01 | -2.90e-01 | 4.6e-01 | 2.00e-02 | 9.8e-01 | 1.90e-01 | 5.8e-01 | -1.13e+00 | 0.0e+00 |
| 5 | Akap12 | 3.20e-01 | 0.0e+00 | -1.70e-01 | 4.0e-01 | 2.50e-01 | 1.6e-01 | -9.00e-02 | 9.4e-01 | 8.00e-02 | 8.1e-01 | -1.13e+00 | 0.0e+00 |
| 19 | Elovl5 | 1.00e-02 | 9.3e-01 | -5.00e-02 | 8.9e-01 | 9.00e-01 | 0.0e+00 | 2.80e-01 | 3.0e-01 | 1.70e-01 | 7.0e-01 | -1.05e+00 | 0.0e+00 |
| 14 | Cdc14b | -3.90e-01 | 5.0e-02 | -1.30e-01 | 8.1e-01 | -3.10e-01 | 3.9e-01 | -6.30e-01 | 8.0e-02 | -4.50e-01 | 1.2e-01 | -1.04e+00 | 0.0e+00 |
| 50 | Spcs3 | -2.00e-01 | 3.3e-01 | -6.00e-02 | 9.3e-01 | -2.30e-01 | 6.7e-01 | -1.00e-02 | 9.9e-01 | 3.00e-02 | 9.6e-01 | -1.02e+00 | 0.0e+00 |
| 44 | Sec24d | 1.90e-01 | 5.0e-02 | 2.00e-02 | 9.7e-01 | 2.20e-01 | 3.7e-01 | 6.50e-01 | 0.0e+00 | 6.40e-01 | 0.0e+00 | -1.00e+00 | 0.0e+00 |
| 11 | B2m | 8.00e-02 | 6.1e-01 | 7.00e-02 | 8.9e-01 | 1.30e-01 | 7.2e-01 | -2.40e-01 | 3.5e-01 | 6.00e-02 | 9.0e-01 | -9.70e-01 | 0.0e+00 |
| 22 | Gnai3 | 5.40e-01 | 0.0e+00 | -6.00e-02 | 8.9e-01 | 2.00e-02 | 9.7e-01 | -8.00e-02 | 8.5e-01 | 9.00e-02 | 8.3e-01 | -9.50e-01 | 0.0e+00 |
| 45 | Selenop | -3.50e-01 | 2.0e-01 | 4.00e-02 | 9.4e-01 | -3.20e-01 | 2.3e-01 | -1.50e-01 | 7.6e-01 | 1.90e-01 | 6.9e-01 | -9.40e-01 | 0.0e+00 |
| 55 | Uap1 | 5.70e-01 | 0.0e+00 | -1.10e-01 | 7.1e-01 | -5.10e-01 | 3.0e-02 | 3.00e-02 | 9.7e-01 | 4.60e-01 | 3.1e-01 | -9.30e-01 | 0.0e+00 |
| 20 | Fads1 | -1.50e-01 | 1.7e-01 | 1.50e-01 | 3.8e-01 | -1.10e+00 | 0.0e+00 | -4.00e-01 | 7.0e-02 | 2.00e-01 | 7.0e-01 | -9.20e-01 | 0.0e+00 |
| 53 | Tnfaip8 | 6.00e-02 | 7.7e-01 | -1.40e-01 | 7.5e-01 | -5.00e-02 | 9.2e-01 | 3.60e-01 | 4.3e-01 | -4.00e-02 | 9.5e-01 | -7.70e-01 | 1.0e-02 |
| 3 | Adamts1 | 1.21e+00 | 0.0e+00 | -3.10e-01 | 4.8e-01 | 1.34e+00 | 0.0e+00 | 8.10e-01 | 1.0e-02 | 1.12e+00 | 0.0e+00 | -7.50e-01 | 0.0e+00 |
| 49 | Sord | -2.70e-01 | 1.2e-01 | -4.00e-02 | 9.3e-01 | -7.20e-01 | 0.0e+00 | -3.40e-01 | 6.0e-02 | 1.00e-02 | 9.9e-01 | -7.40e-01 | 0.0e+00 |
| 24 | Gsr | 2.00e-02 | 9.2e-01 | -6.00e-02 | 8.8e-01 | -4.50e-01 | 0.0e+00 | -2.00e-02 | 9.8e-01 | -1.90e-01 | 5.2e-01 | -7.20e-01 | 0.0e+00 |
| 15 | Cdk6 | -1.40e-01 | 7.7e-01 | -1.80e-01 | 7.7e-01 | 2.80e-01 | 5.6e-01 | -1.40e-01 | 8.9e-01 | 2.00e-01 | 7.6e-01 | -7.20e-01 | 8.0e-02 |
| 12 | B4galt1 | 3.30e-01 | 0.0e+00 | -4.40e-01 | 1.2e-01 | -3.90e-01 | 9.0e-02 | -3.30e-01 | 8.0e-02 | -2.40e-01 | 4.9e-01 | -7.20e-01 | 0.0e+00 |
| 48 | Slc38a2 | 6.70e-01 | 0.0e+00 | -4.40e-01 | 1.4e-01 | -9.00e-02 | 8.2e-01 | 1.36e+00 | 0.0e+00 | 1.00e-01 | 8.4e-01 | -7.10e-01 | 0.0e+00 |
| 30 | Iqgap2 | -5.00e-02 | 8.5e-01 | 2.00e-01 | 6.2e-01 | -5.70e-01 | 1.0e-02 | 3.00e-02 | 9.7e-01 | 3.90e-01 | 2.6e-01 | -6.90e-01 | 2.0e-02 |
| 31 | Itgav | -1.10e-01 | 7.7e-01 | -1.80e-01 | 7.6e-01 | 7.70e-01 | 1.0e-02 | 2.60e-01 | 6.6e-01 | 3.40e-01 | 3.5e-01 | -5.60e-01 | 5.0e-02 |
| 37 | Ncoa4 | 2.50e-01 | 1.0e-02 | -6.00e-02 | 9.2e-01 | 5.00e-02 | 9.2e-01 | 7.00e-01 | 0.0e+00 | 4.10e-01 | 7.0e-02 | -5.10e-01 | 0.0e+00 |
| 47 | Slc26a2 | -3.50e-01 | 3.2e-01 | -7.20e-01 | 2.0e-02 | -2.40e-01 | 6.0e-01 | -3.20e-01 | 6.7e-01 | 5.00e-02 | 9.4e-01 | -4.90e-01 | 1.9e-01 |
| 27 | Hpgd | -1.60e-01 | 5.9e-01 | 1.00e-01 | 9.0e-01 | -3.00e-01 | 5.9e-01 | -3.00e-02 | NA | 1.31e+00 | 0.0e+00 | -4.50e-01 | 3.3e-01 |
| 23 | Gpd1l | 0.00e+00 | 9.9e-01 | -1.70e-01 | 3.6e-01 | -3.90e-01 | 2.0e-02 | 7.10e-01 | 0.0e+00 | 6.50e-01 | 1.0e-02 | -4.40e-01 | 1.0e-02 |
| 8 | Appbp2 | 8.00e-02 | 6.6e-01 | -5.00e-02 | 9.2e-01 | -8.40e-01 | 1.0e-02 | -5.00e-02 | 9.4e-01 | 6.60e-01 | 0.0e+00 | -4.00e-01 | 4.0e-02 |
| 57 | Ube2j1 | 2.90e-01 | 4.0e-02 | 3.00e-02 | 9.7e-01 | 6.30e-01 | 0.0e+00 | 0.00e+00 | 1.0e+00 | 1.90e-01 | 3.7e-01 | -2.90e-01 | 4.0e-02 |
| 25 | Hmgcs1 | -2.00e-01 | 9.0e-02 | 1.00e-01 | 7.3e-01 | -1.29e+00 | 0.0e+00 | -9.30e-01 | 0.0e+00 | -1.30e-01 | 7.0e-01 | -1.30e-01 | 2.8e-01 |
| 7 | Ankh | -1.20e-01 | 4.3e-01 | 3.00e-02 | 9.4e-01 | 1.00e-02 | 9.9e-01 | 6.60e-01 | 1.0e-02 | -2.00e-02 | 9.7e-01 | -7.00e-02 | 7.3e-01 |
| 39 | Ngly1 | 4.00e-02 | 8.1e-01 | -5.00e-02 | 8.8e-01 | -1.12e+00 | 0.0e+00 | 1.50e-01 | 3.8e-01 | -3.00e-02 | 9.4e-01 | -6.00e-02 | 6.8e-01 |
| 56 | Ube2i | 5.00e-02 | 9.4e-01 | -9.00e-02 | NA | 9.10e-01 | 9.0e-02 | 1.80e-01 | NA | -5.00e-01 | 3.8e-01 | -5.00e-02 | 9.5e-01 |
| 29 | Insig1 | 4.60e-01 | 0.0e+00 | 7.30e-01 | 0.0e+00 | 5.10e-01 | 1.0e-02 | 1.89e+00 | 0.0e+00 | 5.20e-01 | 1.6e-01 | 5.00e-02 | 8.5e-01 |
| 17 | Dhcr24 | 5.00e-02 | 8.3e-01 | 2.00e-02 | 9.6e-01 | -3.90e-01 | 1.0e-02 | 1.05e+00 | 0.0e+00 | 1.30e-01 | 8.5e-01 | 1.10e-01 | 6.2e-01 |
| 43 | Sat1 | 9.60e-01 | 0.0e+00 | 2.40e-01 | 5.0e-01 | 5.60e-01 | 4.0e-02 | 1.50e-01 | 7.3e-01 | 6.50e-01 | 5.0e-02 | 1.10e-01 | 7.0e-01 |
| 54 | Tsc22d1 | 2.40e-01 | 7.0e-02 | -1.00e-02 | 9.9e-01 | -6.20e-01 | 0.0e+00 | -8.70e-01 | 0.0e+00 | 9.20e-01 | 0.0e+00 | 2.20e-01 | 1.7e-01 |
| 35 | Mertk | 8.70e-01 | 0.0e+00 | 8.30e-01 | 0.0e+00 | 1.15e+00 | 0.0e+00 | 1.60e-01 | 3.8e-01 | 1.21e+00 | 0.0e+00 | 2.20e-01 | 3.6e-01 |
| 38 | Ndrg1 | 3.10e-01 | 2.0e-02 | 3.10e-01 | 4.0e-02 | 1.87e+00 | 0.0e+00 | 2.70e-01 | 5.3e-01 | 8.10e-01 | 0.0e+00 | 3.20e-01 | 2.6e-01 |
| 58 | Vapa | 5.40e-01 | 0.0e+00 | 2.50e-01 | 5.0e-02 | 6.00e-01 | 0.0e+00 | 4.80e-01 | 0.0e+00 | 1.02e+00 | 0.0e+00 | 3.60e-01 | 2.2e-01 |
| 16 | Dbi | -2.90e-01 | 2.9e-01 | 6.40e-01 | 0.0e+00 | -4.80e-01 | 3.0e-02 | -3.00e-02 | 9.7e-01 | 4.20e-01 | 2.3e-01 | 3.60e-01 | 2.4e-01 |
| 60 | Zmiz1 | 1.80e-01 | 2.2e-01 | 0.00e+00 | 9.9e-01 | 9.60e-01 | 0.0e+00 | 6.00e-02 | 8.7e-01 | 2.50e-01 | 2.1e-01 | 3.70e-01 | 1.8e-01 |
| 42 | Rrp12 | 4.50e-01 | 1.0e-02 | 1.40e-01 | 6.2e-01 | 5.90e-01 | 0.0e+00 | 8.40e-01 | 0.0e+00 | 7.00e-01 | 0.0e+00 | 4.50e-01 | 2.0e-02 |
| 40 | Pdlim5 | -3.00e-02 | 9.5e-01 | -2.50e-01 | 5.6e-01 | -7.20e-01 | 1.0e-02 | 1.30e-01 | 8.6e-01 | 3.90e-01 | 1.1e-01 | 4.70e-01 | 1.0e-02 |
| 59 | Xrcc6 | -4.40e-01 | 0.0e+00 | 1.50e-01 | 5.0e-01 | -7.10e-01 | 0.0e+00 | -2.30e-01 | 4.9e-01 | -7.30e-01 | 0.0e+00 | 4.70e-01 | 2.0e-02 |
| 2 | Acsl3 | 5.00e-02 | 7.9e-01 | 5.10e-01 | 0.0e+00 | -6.20e-01 | 0.0e+00 | -2.50e-01 | 4.6e-01 | -2.00e-01 | 6.0e-01 | 6.10e-01 | 0.0e+00 |
| 46 | Sgk1 | 5.00e-01 | 0.0e+00 | 7.60e-01 | 1.0e-02 | 1.90e-01 | 5.3e-01 | -2.60e-01 | 6.2e-01 | 9.60e-01 | 0.0e+00 | 7.00e-01 | 0.0e+00 |
| 1 | Abcc4 | 4.30e-01 | 0.0e+00 | 8.00e-02 | 8.8e-01 | -6.00e-01 | 2.0e-02 | -9.00e-02 | 9.1e-01 | -1.60e-01 | 7.2e-01 | 8.70e-01 | 0.0e+00 |
| 33 | Maf | -2.10e-01 | 3.8e-01 | -5.80e-01 | 9.0e-02 | -4.30e-01 | 3.3e-01 | -8.70e-01 | 0.0e+00 | -1.50e-01 | 6.8e-01 | 1.00e+00 | 0.0e+00 |
| 4 | Adrm1 | 5.50e-01 | 0.0e+00 | 2.50e-01 | 4.8e-01 | 3.80e-01 | 3.1e-01 | 3.90e-01 | 1.6e-01 | 4.10e-01 | 1.5e-01 | 1.03e+00 | 0.0e+00 |
| 18 | Ell2 | 4.90e-01 | 1.0e-02 | -7.00e-02 | 8.9e-01 | -9.00e-02 | 9.1e-01 | 1.44e+00 | 0.0e+00 | 6.00e-01 | 1.0e-02 | 1.04e+00 | 0.0e+00 |
| 51 | Spdef | 1.50e-01 | 6.2e-01 | 4.70e-01 | NA | 2.21e+00 | 0.0e+00 | 4.00e-01 | NA | 6.50e-01 | NA | 1.14e+00 | 2.0e-02 |
| 34 | Map7 | 5.10e-01 | 0.0e+00 | -7.00e-02 | 8.8e-01 | -5.00e-02 | 8.3e-01 | 3.90e-01 | 1.0e-02 | 1.52e+00 | 0.0e+00 | 1.36e+00 | 0.0e+00 |
| 21 | Fkbp5 | 1.96e+00 | 0.0e+00 | 1.47e+00 | 0.0e+00 | 5.70e-01 | 0.0e+00 | 2.55e+00 | 0.0e+00 | 1.40e+00 | 0.0e+00 | 2.30e+00 | 0.0e+00 |
| 10 | Azgp1 | -7.40e-01 | 7.0e-02 | 1.00e-02 | 9.9e-01 | -4.10e-01 | 4.6e-01 | 3.00e-02 | 9.6e-01 | -2.70e-01 | NA | NA | NA |
AR %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S20. Relative changes in the expression of genes involved in AR signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))FGFR%>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>%kable(caption = "Supplementary Table 21. Relative changes in the expression of genes involved in FGFR signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(FGFR$Adrenal_padj),F,ifelse(FGFR$Adrenal_padj<.1,T,F)),color= ifelse(is.na(FGFR$Adrenal_padj),"gray",ifelse(FGFR$Adrenal_padj<.1,spec_color(FGFR$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(FGFR$HT_padj),F,ifelse(FGFR$HT_padj<.1,T,F)),color= ifelse(is.na(FGFR$HT_padj),"gray",ifelse(FGFR$HT_padj<.1,spec_color(FGFR$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(FGFR$Liver_padj),F,ifelse(FGFR$Liver_padj<.1,T,F)),color= ifelse(is.na(FGFR$Liver_padj),"gray",ifelse(FGFR$Liver_padj<.1,spec_color(FGFR$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(FGFR$Lung_padj),F,ifelse(FGFR$Lung_padj<.1,T,F)),color= ifelse(is.na(FGFR$Lung_padj),"gray",ifelse(FGFR$Lung_padj <.1,spec_color(FGFR$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(FGFR$Adipose_padj),F,ifelse(FGFR$Adipose_padj<.1,T,F)),color= ifelse(is.na(FGFR$Adipose_padj),"gray",ifelse(FGFR$Adipose_padj<.1, spec_color(FGFR$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(FGFR$Muscle_padj),F,ifelse(FGFR$Muscle_padj<.1,T,F)),color= ifelse(is.na(FGFR$Muscle_padj),"gray",ifelse(FGFR$Muscle_padj<.1,spec_color(FGFR$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 15 | Flrt3 | -6.6e-01 | 0.0e+00 | -2.2e-01 | 4.2e-01 | 6.20e-01 | 2.0e-02 | -5.50e-01 | 3.4e-01 | -5.90e-01 | 6.0e-02 | -1.80e+00 | 0.0e+00 |
| 5 | Fgf16 | -1.4e-01 | 8.0e-01 | 1.0e-02 | NA | -9.90e-01 | 8.0e-02 | 1.00e-02 | NA | -1.00e-02 | 9.9e-01 | -1.23e+00 | 2.0e-02 |
| 7 | Fgf9 | -4.4e-01 | 2.8e-01 | -3.7e-01 | 5.0e-02 | -7.30e-01 | 1.0e-01 | -9.00e-02 | NA | -1.80e-01 | 8.0e-01 | -1.13e+00 | 1.0e-02 |
| 14 | Flrt2 | 3.7e-01 | 2.6e-01 | -4.5e-01 | 2.7e-01 | 2.50e-01 | 4.2e-01 | -7.00e-02 | 9.6e-01 | 1.80e-01 | 7.8e-01 | -1.12e+00 | 0.0e+00 |
| 13 | Flrt1 | -4.1e-01 | 3.9e-01 | -2.6e-01 | 4.4e-01 | -2.30e-01 | 7.2e-01 | -5.00e-02 | 9.7e-01 | -4.20e-01 | 5.0e-01 | -1.11e+00 | 0.0e+00 |
| 3 | Fgf1 | -1.0e-01 | 5.3e-01 | -1.6e-01 | 4.2e-01 | -8.00e-02 | 8.7e-01 | -3.60e-01 | 3.7e-01 | -1.40e-01 | 7.2e-01 | -1.07e+00 | 0.0e+00 |
| 4 | Fgf10 | 2.0e-02 | 9.6e-01 | 2.0e-02 | 9.8e-01 | -4.30e-01 | 3.9e-01 | -3.30e-01 | 6.0e-01 | -7.90e-01 | 1.0e-02 | -1.05e+00 | 2.0e-02 |
| 39 | Spred1 | -1.0e-01 | 8.2e-01 | -2.1e-01 | 7.2e-01 | 1.40e-01 | 7.3e-01 | -5.30e-01 | 2.1e-01 | -1.50e-01 | 7.4e-01 | -1.01e+00 | 0.0e+00 |
| 26 | Ncbp2 | -1.1e-01 | 3.8e-01 | -4.0e-02 | 9.4e-01 | -4.50e-01 | 4.0e-02 | -3.00e-01 | 8.0e-02 | 1.00e-01 | 7.7e-01 | -9.40e-01 | 0.0e+00 |
| 23 | Klb | -2.2e-01 | 5.1e-01 | 6.0e-02 | NA | 1.40e-01 | 8.6e-01 | -8.00e-02 | 9.2e-01 | 7.40e-01 | 3.0e-02 | -7.90e-01 | 2.6e-01 |
| 10 | Fgfr2 | -2.7e-01 | 3.0e-02 | -5.0e-02 | 9.1e-01 | 4.20e-01 | 2.0e-02 | -8.70e-01 | 0.0e+00 | -1.18e+00 | 0.0e+00 | -7.10e-01 | 1.8e-01 |
| 24 | Mapk3 | 2.4e-01 | 5.0e-02 | 4.0e-02 | 9.5e-01 | 1.10e-01 | 7.1e-01 | 4.40e-01 | 5.0e-02 | 5.00e-02 | 9.3e-01 | -6.90e-01 | 0.0e+00 |
| 40 | Spred2 | 3.0e-02 | 9.0e-01 | -3.0e-01 | 3.4e-01 | 4.20e-01 | 1.3e-01 | 1.00e-02 | 1.0e+00 | -1.80e-01 | 5.3e-01 | -6.90e-01 | 0.0e+00 |
| 9 | Fgfr1 | -2.6e-01 | 3.5e-01 | 3.0e-02 | 9.6e-01 | 4.10e-01 | 0.0e+00 | -2.80e-01 | 6.0e-01 | -2.60e-01 | 3.9e-01 | -6.30e-01 | 1.0e-02 |
| 18 | Galnt3 | -6.0e-01 | 0.0e+00 | 5.0e-02 | 9.5e-01 | 1.61e+00 | 0.0e+00 | -1.90e-01 | NA | -1.00e-01 | NA | -6.20e-01 | NA |
| 34 | Ppp2ca | 1.3e-01 | 7.3e-01 | -6.0e-02 | 9.2e-01 | 2.90e-01 | 5.9e-01 | 1.07e+00 | 0.0e+00 | 4.80e-01 | 2.5e-01 | -5.40e-01 | 1.0e-01 |
| 35 | Ppp2cb | 9.0e-02 | 5.4e-01 | -2.0e-02 | 9.8e-01 | 6.00e-01 | 6.0e-02 | -1.40e-01 | 8.1e-01 | 3.10e-01 | 3.8e-01 | -4.70e-01 | 9.0e-02 |
| 36 | Ptbp1 | -2.0e-02 | 9.5e-01 | 0.0e+00 | 1.0e+00 | 8.10e-01 | 0.0e+00 | -4.00e-02 | 9.4e-01 | -4.00e-02 | 9.0e-01 | -2.90e-01 | 1.4e-01 |
| 12 | Fgfr4 | -7.2e-01 | 0.0e+00 | -2.3e-01 | 6.8e-01 | -1.80e-01 | 7.5e-01 | -2.80e-01 | 6.0e-02 | -9.20e-01 | 5.0e-02 | -1.60e-01 | 6.1e-01 |
| 21 | Hnrnpa1 | 2.3e-01 | 1.0e-02 | 2.3e-01 | 1.0e-01 | 9.80e-01 | 0.0e+00 | 4.70e-01 | 0.0e+00 | 5.10e-01 | 1.0e-02 | -9.00e-02 | 5.4e-01 |
| 11 | Fgfr3 | -1.3e-01 | 3.9e-01 | 2.2e-01 | 2.4e-01 | 2.70e-01 | 1.5e-01 | 2.70e-01 | 1.9e-01 | 7.20e-01 | 3.0e-02 | -5.00e-02 | 9.3e-01 |
| 38 | Sos1 | 2.0e-02 | 9.6e-01 | -2.3e-01 | 5.7e-01 | 1.10e-01 | 7.1e-01 | 5.90e-01 | 1.0e-02 | -1.00e-02 | 9.8e-01 | 1.00e-01 | 6.3e-01 |
| 8 | Fgfbp1 | -9.1e-01 | 0.0e+00 | -6.0e-02 | NA | 1.90e-01 | NA | -1.90e-01 | NA | -5.90e-01 | NA | 1.50e-01 | NA |
| 16 | Frs3 | -3.1e-01 | 4.6e-01 | 1.2e-01 | 7.7e-01 | -1.80e-01 | 7.6e-01 | -1.60e-01 | 8.5e-01 | -7.30e-01 | 2.0e-02 | 2.10e-01 | 6.3e-01 |
| 28 | Polr2d | 2.5e-01 | 9.0e-02 | 3.4e-01 | 2.2e-01 | 1.50e-01 | 6.9e-01 | 5.10e-01 | 0.0e+00 | 6.70e-01 | 0.0e+00 | 2.50e-01 | 2.0e-01 |
| 37 | Ptpn11 | 2.4e-01 | 2.0e-02 | 3.3e-01 | 5.0e-02 | -2.00e-01 | 5.1e-01 | -1.00e-02 | 9.9e-01 | 9.50e-01 | 0.0e+00 | 4.00e-01 | 0.0e+00 |
| 1 | Braf | -1.4e-01 | 7.6e-01 | -1.2e-01 | 8.7e-01 | 9.10e-01 | 1.0e-02 | 0.00e+00 | 1.0e+00 | 6.20e-01 | 9.0e-02 | 4.70e-01 | 5.0e-02 |
| 25 | Mknk1 | 1.0e-01 | 5.0e-01 | 1.0e-01 | 8.2e-01 | -5.40e-01 | 0.0e+00 | 7.00e-01 | 0.0e+00 | 8.60e-01 | 0.0e+00 | 4.90e-01 | 3.0e-02 |
| 20 | Gtf2f2 | -5.0e-02 | 8.6e-01 | 4.0e-02 | 9.5e-01 | 7.10e-01 | 0.0e+00 | -3.00e-02 | 9.8e-01 | 3.30e-01 | 2.0e-01 | 5.10e-01 | 1.0e-02 |
| 41 | Ubb | 4.4e-01 | 0.0e+00 | 2.6e-01 | 2.5e-01 | -7.80e-01 | 0.0e+00 | 1.00e-01 | 8.6e-01 | 1.10e-01 | 7.6e-01 | 6.00e-01 | 0.0e+00 |
| 29 | Polr2e | 1.0e-01 | 7.5e-01 | 4.5e-01 | 1.4e-01 | 1.00e-02 | 9.9e-01 | -1.00e-02 | 9.9e-01 | 1.00e-01 | 8.7e-01 | 7.40e-01 | 2.0e-02 |
| 19 | Gtf2f1 | 5.3e-01 | 1.0e-02 | 3.9e-01 | 2.0e-01 | 3.50e-01 | 3.6e-01 | 6.40e-01 | 5.0e-02 | 5.90e-01 | 5.0e-02 | 7.60e-01 | 0.0e+00 |
| 32 | Polr2k | 1.6e-01 | 5.6e-01 | 2.8e-01 | 3.2e-01 | -1.50e-01 | 7.2e-01 | 6.00e-02 | 9.5e-01 | 5.70e-01 | 1.8e-01 | 8.00e-01 | 1.0e-02 |
| 30 | Polr2f | -2.3e-01 | 5.4e-01 | 3.9e-01 | 3.4e-01 | 8.00e-02 | 8.9e-01 | 0.00e+00 | 1.0e+00 | 2.20e-01 | 6.5e-01 | 8.10e-01 | 2.0e-02 |
| 17 | Gab1 | 1.2e-01 | 6.9e-01 | -3.7e-01 | 3.7e-01 | -2.40e-01 | 5.5e-01 | -2.30e-01 | 6.7e-01 | -1.60e-01 | 6.5e-01 | 1.00e+00 | 0.0e+00 |
| 33 | Polr2l | 9.0e-02 | 8.8e-01 | 2.6e-01 | 6.1e-01 | 2.10e-01 | 7.1e-01 | 3.00e-02 | 9.8e-01 | 2.20e-01 | 7.7e-01 | 1.01e+00 | 0.0e+00 |
| 31 | Polr2j | -9.0e-02 | 8.2e-01 | 2.6e-01 | 5.5e-01 | -3.20e-01 | 4.5e-01 | -1.00e-02 | 1.0e+00 | 2.20e-01 | 7.2e-01 | 1.06e+00 | 0.0e+00 |
| 2 | Esrp2 | 2.9e-01 | 4.0e-02 | -1.0e-02 | 9.9e-01 | -2.80e-01 | 4.6e-01 | 3.00e-01 | 3.0e-02 | 9.30e-01 | 1.0e-02 | 1.21e+00 | 8.0e-02 |
| 27 | Pik3r1 | 1.1e-01 | 7.6e-01 | 1.0e-01 | 8.6e-01 | -7.00e-02 | 8.4e-01 | 5.90e-01 | 0.0e+00 | 3.70e-01 | 9.0e-02 | 1.27e+00 | 0.0e+00 |
| 22 | Hras | 1.3e-01 | 6.7e-01 | 3.9e-01 | 2.0e-01 | 1.10e-01 | 8.3e-01 | 2.10e-01 | 6.9e-01 | -2.00e-02 | 9.6e-01 | 1.46e+00 | 0.0e+00 |
| 42 | Ubc | 9.3e-01 | 0.0e+00 | 1.2e-01 | 7.0e-01 | -2.90e-01 | 3.1e-01 | -7.50e-01 | 0.0e+00 | 3.10e-01 | 2.4e-01 | 1.48e+00 | 0.0e+00 |
| 6 | Fgf2 | 3.9e-01 | 4.2e-01 | 5.1e-01 | 1.9e-01 | -7.70e-01 | 2.0e-01 | 2.50e-01 | NA | 1.22e+00 | 0.0e+00 | 1.91e+00 | 0.0e+00 |
FGFR %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S21. Relative changes in the expression of genes involved in FGFR signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))EarlyEstrogen%>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>%kable(caption = "Supplementary Table 22. Relative changes in the expression of genes involved in early estrogen response after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(EarlyEstrogen$Adrenal_padj),F,ifelse(EarlyEstrogen$Adrenal_padj<.1,T,F)),color= ifelse(is.na(EarlyEstrogen$Adrenal_padj),"gray",ifelse(EarlyEstrogen$Adrenal_padj<.1,spec_color(EarlyEstrogen$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(EarlyEstrogen$HT_padj),F,ifelse(EarlyEstrogen$HT_padj<.1,T,F)),color= ifelse(is.na(EarlyEstrogen$HT_padj),"gray",ifelse(EarlyEstrogen$HT_padj<.1,spec_color(EarlyEstrogen$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(EarlyEstrogen$Liver_padj),F,ifelse(EarlyEstrogen$Liver_padj<.1,T,F)),color= ifelse(is.na(EarlyEstrogen$Liver_padj),"gray",ifelse(EarlyEstrogen$Liver_padj<.1,spec_color(EarlyEstrogen$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(EarlyEstrogen$Lung_padj),F,ifelse(EarlyEstrogen$Lung_padj<.1,T,F)),color= ifelse(is.na(EarlyEstrogen$Lung_padj),"gray",ifelse(EarlyEstrogen$Lung_padj <.1,spec_color(EarlyEstrogen$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(EarlyEstrogen$Adipose_padj),F,ifelse(EarlyEstrogen$Adipose_padj<.1,T,F)),color= ifelse(is.na(EarlyEstrogen$Adipose_padj),"gray",ifelse(EarlyEstrogen$Adipose_padj<.1, spec_color(EarlyEstrogen$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(EarlyEstrogen$Muscle_padj),F,ifelse(EarlyEstrogen$Muscle_padj<.1,T,F)),color= ifelse(is.na(EarlyEstrogen$Muscle_padj),"gray",ifelse(EarlyEstrogen$Muscle_padj<.1,spec_color(EarlyEstrogen$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 16 | Ccnd1 | -5.70e-01 | 0.0e+00 | -8.80e-01 | 0.0e+00 | -7.20e-01 | 0.0e+00 | -1.03e+00 | 0.0e+00 | -8.20e-01 | 0.0e+00 | -2.57e+00 | 0.0e+00 |
| 26 | Egr3 | -9.60e-01 | 1.0e-02 | 1.10e-01 | 8.8e-01 | 1.66e+00 | 0.0e+00 | -2.00e-02 | 9.9e-01 | -9.00e-02 | 9.2e-01 | -2.25e+00 | 0.0e+00 |
| 59 | Lad1 | 1.10e-01 | 6.9e-01 | -1.00e-02 | NA | 1.30e-01 | NA | 3.50e-01 | 6.5e-01 | -5.00e-02 | 9.5e-01 | -2.02e+00 | 0.0e+00 |
| 18 | Celsr1 | -7.00e-02 | 6.8e-01 | 7.00e-02 | 8.3e-01 | 1.00e-02 | 9.8e-01 | -9.00e-02 | 9.5e-01 | 1.00e-01 | 9.1e-01 | -1.98e+00 | 0.0e+00 |
| 103 | Slc2a1 | 3.60e-01 | 6.0e-02 | 6.30e-01 | 2.0e-02 | 2.90e-01 | 5.8e-01 | 3.50e-01 | 4.4e-01 | -1.00e-02 | 9.9e-01 | -1.88e+00 | 0.0e+00 |
| 86 | Rasgrp1 | -1.05e+00 | 0.0e+00 | 1.00e-02 | 9.9e-01 | 9.00e-02 | 9.0e-01 | -3.90e-01 | 3.9e-01 | -5.50e-01 | 1.5e-01 | -1.87e+00 | 0.0e+00 |
| 14 | Calcr | 0.00e+00 | NA | 1.80e-01 | 6.4e-01 | -6.20e-01 | 2.8e-01 | 4.00e-02 | NA | -3.60e-01 | NA | -1.65e+00 | 0.0e+00 |
| 31 | Fam102a | -1.00e-01 | 5.3e-01 | -1.90e-01 | 4.5e-01 | -2.00e-01 | 5.1e-01 | -1.70e-01 | 7.3e-01 | -3.60e-01 | 3.5e-01 | -1.64e+00 | 0.0e+00 |
| 12 | Bhlhe40 | 7.20e-01 | 0.0e+00 | 2.00e-01 | 5.5e-01 | 9.50e-01 | 0.0e+00 | -1.07e+00 | 0.0e+00 | -7.90e-01 | 1.0e-02 | -1.60e+00 | 0.0e+00 |
| 17 | Cd44 | -1.00e-01 | 5.0e-01 | 2.40e-01 | 5.1e-01 | 0.00e+00 | 1.0e+00 | -5.00e-02 | 9.8e-01 | -4.90e-01 | 2.0e-01 | -1.59e+00 | 0.0e+00 |
| 20 | Cxcl12 | -4.50e-01 | 0.0e+00 | -6.50e-01 | 0.0e+00 | -2.50e-01 | 4.1e-01 | -4.90e-01 | 0.0e+00 | -5.70e-01 | 1.0e-02 | -1.56e+00 | 0.0e+00 |
| 40 | Frk | -3.20e-01 | 1.4e-01 | -4.00e-01 | 3.5e-01 | -4.20e-01 | 2.0e-01 | -2.70e-01 | 3.7e-01 | -1.50e-01 | 8.1e-01 | -1.54e+00 | 0.0e+00 |
| 10 | Bcl11b | -7.00e-01 | 0.0e+00 | -1.00e-02 | 9.9e-01 | 1.80e-01 | 7.4e-01 | -1.50e-01 | 8.9e-01 | -3.20e-01 | 6.3e-01 | -1.53e+00 | 2.0e-02 |
| 119 | Tsku | -3.10e-01 | 3.8e-01 | 8.00e-02 | 8.8e-01 | 4.80e-01 | 2.2e-01 | 1.00e-02 | 9.9e-01 | 3.30e-01 | 1.0e-01 | -1.50e+00 | 0.0e+00 |
| 58 | Krt19 | 2.50e-01 | 2.7e-01 | -3.70e-01 | 4.1e-01 | 7.60e-01 | 1.7e-01 | 2.80e-01 | 7.4e-01 | -4.00e-02 | 9.5e-01 | -1.49e+00 | 3.0e-02 |
| 13 | Blvrb | -2.70e-01 | 3.0e-02 | 4.00e-02 | 9.4e-01 | -2.50e-01 | 4.7e-01 | -1.90e-01 | 4.9e-01 | -3.00e-02 | 9.7e-01 | -1.42e+00 | 0.0e+00 |
| 118 | Tpd52l1 | 1.90e-01 | 7.1e-01 | 1.70e-01 | 6.1e-01 | -2.90e-01 | 5.8e-01 | 4.10e-01 | 5.6e-01 | -1.70e-01 | 8.4e-01 | -1.39e+00 | 0.0e+00 |
| 34 | Fcmr | -9.70e-01 | 0.0e+00 | -2.80e-01 | 5.8e-01 | -1.70e-01 | 7.8e-01 | -6.90e-01 | 1.9e-01 | 1.00e-02 | 9.9e-01 | -1.37e+00 | 0.0e+00 |
| 81 | Ptges | -2.10e-01 | 7.1e-01 | -7.00e-02 | 9.3e-01 | -6.00e-02 | 9.1e-01 | -2.00e-02 | NA | -3.60e-01 | 4.9e-01 | -1.31e+00 | 0.0e+00 |
| 19 | Cish | 3.20e-01 | 1.1e-01 | -3.90e-01 | 3.6e-01 | -1.03e+00 | 1.0e-02 | -1.74e+00 | 0.0e+00 | -9.70e-01 | 2.0e-02 | -1.30e+00 | 4.0e-02 |
| 67 | Mybl1 | -3.00e-01 | 3.7e-01 | -1.40e-01 | 7.6e-01 | -1.30e-01 | 8.5e-01 | -5.40e-01 | 3.2e-01 | -6.50e-01 | 6.0e-02 | -1.28e+00 | 0.0e+00 |
| 3 | Add3 | 1.10e-01 | 6.7e-01 | 2.00e-02 | 9.8e-01 | 1.30e-01 | 8.7e-01 | -4.60e-01 | 3.1e-01 | -4.00e-02 | 9.4e-01 | -1.28e+00 | 0.0e+00 |
| 69 | Myof | 0.00e+00 | 9.9e-01 | -1.00e-01 | 8.6e-01 | -1.17e+00 | 0.0e+00 | -2.10e-01 | 7.9e-01 | -1.70e-01 | 7.3e-01 | -1.28e+00 | 0.0e+00 |
| 98 | Slc16a1 | 3.60e-01 | 1.6e-01 | -6.00e-02 | 9.2e-01 | 1.19e+00 | 0.0e+00 | -9.00e-02 | 9.0e-01 | 6.90e-01 | 0.0e+00 | -1.23e+00 | 0.0e+00 |
| 117 | Tpbg | 6.80e-01 | 0.0e+00 | -9.00e-02 | 6.8e-01 | -5.80e-01 | 0.0e+00 | -4.00e-01 | 2.5e-01 | -9.00e-02 | 9.2e-01 | -1.19e+00 | 2.0e-02 |
| 111 | Tgif2 | -1.60e-01 | 6.1e-01 | -1.90e-01 | 6.7e-01 | 7.80e-01 | 0.0e+00 | -3.90e-01 | 3.1e-01 | -4.20e-01 | 3.6e-01 | -1.18e+00 | 1.0e-02 |
| 15 | Cbfa2t3 | -1.20e-01 | 6.2e-01 | -3.40e-01 | 1.9e-01 | 3.00e-02 | 9.4e-01 | -3.30e-01 | 6.5e-01 | 0.00e+00 | 1.0e+00 | -1.18e+00 | 0.0e+00 |
| 57 | Klf4 | 1.30e-01 | 6.2e-01 | -3.00e-02 | 9.7e-01 | 7.40e-01 | 0.0e+00 | -3.00e-02 | 9.8e-01 | 1.23e+00 | 0.0e+00 | -1.16e+00 | 0.0e+00 |
| 100 | Slc1a1 | 1.60e-01 | 2.8e-01 | 1.00e-02 | 9.8e-01 | 5.10e-01 | 0.0e+00 | -2.10e-01 | NA | -3.50e-01 | 4.1e-01 | -1.10e+00 | 0.0e+00 |
| 36 | Fhl2 | 3.90e-01 | 6.0e-02 | 7.00e-02 | 9.2e-01 | -1.30e-01 | 5.0e-01 | 2.90e-01 | 5.6e-01 | 7.30e-01 | 1.0e-02 | -1.08e+00 | 1.0e-01 |
| 42 | Gfra1 | -2.70e-01 | 3.3e-01 | 2.10e-01 | 5.1e-01 | 1.28e+00 | 0.0e+00 | -2.00e-02 | 9.8e-01 | 2.80e-01 | 6.2e-01 | -1.08e+00 | 0.0e+00 |
| 115 | Tmem164 | -1.60e-01 | 1.7e-01 | -3.10e-01 | 1.3e-01 | -1.52e+00 | 0.0e+00 | -1.30e-01 | 7.3e-01 | -3.90e-01 | 7.0e-02 | -1.08e+00 | 0.0e+00 |
| 25 | Dlc1 | -1.40e-01 | 3.3e-01 | -1.40e-01 | 7.3e-01 | -1.90e-01 | 6.8e-01 | -5.40e-01 | 9.0e-02 | 3.00e-02 | 9.5e-01 | -1.06e+00 | 0.0e+00 |
| 28 | Elovl5 | 1.00e-02 | 9.3e-01 | -5.00e-02 | 8.9e-01 | 9.00e-01 | 0.0e+00 | 2.80e-01 | 3.0e-01 | 1.70e-01 | 7.0e-01 | -1.05e+00 | 0.0e+00 |
| 121 | Ugcg | 6.00e-02 | 7.9e-01 | -2.00e-02 | 9.7e-01 | -6.80e-01 | 3.0e-02 | -3.90e-01 | 3.2e-01 | -4.00e-02 | 9.5e-01 | -1.02e+00 | 0.0e+00 |
| 95 | Sema3b | 1.90e-01 | 3.2e-01 | -1.30e-01 | 8.5e-01 | -5.00e-02 | 9.1e-01 | -1.50e-01 | 8.9e-01 | 6.00e-02 | 9.2e-01 | -1.00e+00 | 0.0e+00 |
| 1 | Ablim1 | 7.50e-01 | 0.0e+00 | -2.40e-01 | 5.8e-01 | 8.70e-01 | 0.0e+00 | 1.40e-01 | 8.4e-01 | 1.10e-01 | 7.2e-01 | -9.90e-01 | 1.0e-02 |
| 39 | Foxc1 | -6.00e-01 | 7.0e-02 | -4.10e-01 | 3.4e-01 | 4.50e-01 | 8.0e-02 | -4.90e-01 | NA | -8.00e-02 | 9.2e-01 | -9.30e-01 | 0.0e+00 |
| 101 | Slc1a4 | -1.50e-01 | 3.1e-01 | -3.00e-02 | 9.3e-01 | 8.00e-02 | 8.4e-01 | 1.21e+00 | 0.0e+00 | 5.00e-01 | 1.0e-02 | -9.10e-01 | 0.0e+00 |
| 94 | Sec14l2 | 1.07e+00 | 0.0e+00 | 3.60e-01 | 6.0e-02 | -3.00e-02 | 9.7e-01 | 1.10e-01 | 7.1e-01 | 2.60e-01 | 6.4e-01 | -9.10e-01 | 9.0e-02 |
| 83 | Rab31 | 1.90e-01 | 8.0e-02 | 4.80e-01 | 1.0e-02 | 1.30e-01 | 6.3e-01 | 1.10e-01 | 8.8e-01 | 1.00e-01 | 8.0e-01 | -9.00e-01 | 0.0e+00 |
| 88 | Ret | 3.00e-02 | 9.3e-01 | 2.60e-01 | 5.1e-01 | 2.51e+00 | 0.0e+00 | -3.00e-01 | 7.0e-01 | 3.00e-02 | 9.7e-01 | -8.90e-01 | 1.0e-02 |
| 21 | Cyp26b1 | -1.04e+00 | 0.0e+00 | -3.60e-01 | 3.8e-01 | 5.50e-01 | 2.7e-01 | 6.70e-01 | 1.8e-01 | -4.40e-01 | 4.3e-01 | -8.90e-01 | 3.0e-02 |
| 23 | Dhcr7 | -3.30e-01 | 9.0e-02 | 1.50e-01 | 7.8e-01 | -4.40e-01 | 1.8e-01 | 1.90e-01 | 6.0e-01 | 1.50e-01 | 8.0e-01 | -8.60e-01 | 4.0e-02 |
| 27 | Elf1 | 1.00e-02 | 9.8e-01 | -3.30e-01 | 3.0e-01 | 1.00e-02 | 9.8e-01 | -2.60e-01 | 3.4e-01 | 3.00e-02 | 9.5e-01 | -8.50e-01 | 0.0e+00 |
| 50 | Inpp5f | -2.50e-01 | 3.0e-02 | -7.00e-02 | 8.3e-01 | -4.40e-01 | 1.0e-02 | -6.00e-02 | 7.9e-01 | -2.90e-01 | 2.2e-01 | -8.40e-01 | 0.0e+00 |
| 74 | Olfml3 | -1.20e-01 | 6.5e-01 | 2.00e-02 | 9.8e-01 | 3.50e-01 | 1.6e-01 | 7.00e-02 | 9.4e-01 | 2.00e-01 | 5.9e-01 | -8.10e-01 | 1.0e-02 |
| 53 | Kazn | 8.30e-01 | 0.0e+00 | 3.10e-01 | 7.0e-02 | 7.70e-01 | 1.0e-02 | -3.90e-01 | 5.6e-01 | 1.00e-02 | 9.9e-01 | -7.90e-01 | 3.0e-02 |
| 123 | Wwc1 | -5.60e-01 | 0.0e+00 | -1.20e-01 | 6.0e-01 | 2.20e-01 | 7.3e-01 | -8.70e-01 | 0.0e+00 | -7.00e-02 | 8.9e-01 | -7.80e-01 | NA |
| 79 | Podxl | -6.40e-01 | 0.0e+00 | -6.90e-01 | 0.0e+00 | 3.00e-01 | 0.0e+00 | -2.70e-01 | 7.0e-01 | -2.60e-01 | 3.2e-01 | -7.70e-01 | 0.0e+00 |
| 104 | Slc39a6 | -3.00e-02 | 8.8e-01 | 1.00e-02 | 9.9e-01 | 1.30e-01 | 6.6e-01 | 1.30e-01 | 6.9e-01 | -1.70e-01 | 6.7e-01 | -7.70e-01 | 0.0e+00 |
| 49 | Inhbb | -1.00e-01 | 6.1e-01 | -3.00e-01 | 4.5e-01 | -9.40e-01 | 0.0e+00 | -1.10e-01 | 9.2e-01 | -1.23e+00 | 0.0e+00 | -7.60e-01 | 1.0e-02 |
| 38 | Fos | 1.01e+00 | 0.0e+00 | -6.40e-01 | 1.0e-02 | 4.60e-01 | 3.1e-01 | 3.90e-01 | 6.0e-01 | 3.20e-01 | NA | -7.50e-01 | 2.4e-01 |
| 47 | Igfbp4 | 1.10e-01 | 6.9e-01 | 7.00e-02 | 9.3e-01 | 1.40e-01 | 7.3e-01 | 1.30e-01 | 6.0e-01 | 6.50e-01 | 1.0e-02 | -7.40e-01 | 0.0e+00 |
| 90 | Rhod | -9.00e-02 | 8.2e-01 | -3.10e-01 | 5.3e-01 | -6.20e-01 | 1.0e-01 | 9.00e-02 | 8.8e-01 | 2.00e-02 | 9.7e-01 | -7.30e-01 | 3.3e-01 |
| 9 | B4galt1 | 3.30e-01 | 0.0e+00 | -4.40e-01 | 1.2e-01 | -3.90e-01 | 9.0e-02 | -3.30e-01 | 8.0e-02 | -2.40e-01 | 4.9e-01 | -7.20e-01 | 0.0e+00 |
| 73 | Olfm1 | -1.30e-01 | 6.8e-01 | 3.30e-01 | 2.6e-01 | 4.20e-01 | 2.0e-01 | -1.60e-01 | 8.9e-01 | 2.00e-02 | 9.8e-01 | -7.10e-01 | 1.0e-02 |
| 63 | Micb | -1.00e-02 | 9.5e-01 | -1.10e-01 | 8.8e-01 | 5.00e-02 | 9.0e-01 | -2.50e-01 | 7.7e-01 | -2.00e-02 | 9.6e-01 | -6.90e-01 | 2.0e-02 |
| 85 | Rara | -1.00e-02 | 9.8e-01 | -1.30e-01 | 7.3e-01 | 2.60e-01 | 1.1e-01 | 7.00e-02 | 8.6e-01 | -3.40e-01 | 3.7e-01 | -6.60e-01 | 0.0e+00 |
| 99 | Slc19a2 | 3.60e-01 | 0.0e+00 | -1.90e-01 | 3.7e-01 | 1.70e-01 | 3.9e-01 | -1.00e+00 | 0.0e+00 | -6.00e-02 | 8.8e-01 | -6.20e-01 | 3.0e-02 |
| 29 | Endod1 | 7.30e-01 | 0.0e+00 | 1.00e-01 | 8.4e-01 | -5.50e-01 | 1.0e-02 | 6.00e-02 | 9.6e-01 | 9.00e-02 | 8.8e-01 | -6.20e-01 | 2.0e-02 |
| 54 | Kcnk5 | 6.70e-01 | 2.0e-02 | -1.90e-01 | 7.3e-01 | -9.10e-01 | 1.0e-02 | 3.40e-01 | 2.5e-01 | -5.40e-01 | 1.6e-01 | -5.30e-01 | 2.2e-01 |
| 84 | Rapgefl1 | 3.00e-01 | 3.8e-01 | 1.00e-02 | 9.9e-01 | 8.90e-01 | 7.0e-02 | -1.40e-01 | 9.0e-01 | -1.20e-01 | 8.9e-01 | -4.90e-01 | 4.3e-01 |
| 102 | Slc26a2 | -3.50e-01 | 3.2e-01 | -7.20e-01 | 2.0e-02 | -2.40e-01 | 6.0e-01 | -3.20e-01 | 6.7e-01 | 5.00e-02 | 9.4e-01 | -4.90e-01 | 1.9e-01 |
| 33 | Fasn | 8.30e-01 | 0.0e+00 | 0.00e+00 | 9.9e-01 | -1.30e-01 | 8.2e-01 | -6.40e-01 | 7.0e-02 | -2.40e-01 | 7.4e-01 | -4.80e-01 | 2.3e-01 |
| 89 | Rhobtb3 | -2.70e-01 | 2.0e-01 | -1.70e-01 | 6.8e-01 | -1.07e+00 | 0.0e+00 | 8.00e-02 | 8.9e-01 | -6.30e-01 | 4.0e-02 | -4.40e-01 | 1.0e-02 |
| 65 | Mpped2 | 9.00e-02 | 7.5e-01 | -3.00e-02 | 9.5e-01 | -8.00e-01 | 0.0e+00 | -7.00e-01 | NA | -1.40e-01 | 8.7e-01 | -4.20e-01 | 1.9e-01 |
| 107 | Snx24 | -7.00e-02 | 7.5e-01 | 2.20e-01 | 2.1e-01 | -1.70e-01 | 7.3e-01 | -6.30e-01 | 0.0e+00 | 0.00e+00 | 1.0e+00 | -4.20e-01 | 4.0e-02 |
| 35 | Fdft1 | -1.80e-01 | 7.0e-02 | 9.00e-02 | 8.2e-01 | -8.20e-01 | 0.0e+00 | -6.10e-01 | 0.0e+00 | -2.40e-01 | 6.2e-01 | -4.00e-01 | 2.0e-02 |
| 45 | Hr | 3.30e-01 | 9.0e-02 | 5.00e-01 | 0.0e+00 | 1.80e-01 | 6.3e-01 | 2.00e-02 | 9.9e-01 | -6.90e-01 | 6.0e-02 | -3.70e-01 | 8.0e-02 |
| 70 | Nbl1 | 5.00e-02 | 8.9e-01 | -1.00e-01 | 8.8e-01 | 7.30e-01 | 0.0e+00 | -9.00e-02 | 9.5e-01 | -4.00e-02 | 9.6e-01 | -2.90e-01 | 1.7e-01 |
| 77 | Pex11a | 1.36e+00 | 0.0e+00 | 1.01e+00 | 0.0e+00 | -8.90e-01 | 0.0e+00 | 1.93e+00 | 0.0e+00 | -6.00e-02 | 9.0e-01 | -2.80e-01 | 3.3e-01 |
| 93 | Scnn1a | 5.30e-01 | 0.0e+00 | -3.00e-01 | 4.7e-01 | 7.60e-01 | 1.0e-01 | -6.10e-01 | 1.5e-01 | -3.00e-01 | 5.4e-01 | -2.80e-01 | 6.2e-01 |
| 92 | Scarb1 | -1.60e-01 | 5.4e-01 | 1.00e-01 | 8.9e-01 | 1.22e+00 | 0.0e+00 | 1.10e-01 | 8.4e-01 | -1.80e-01 | 5.5e-01 | -2.40e-01 | 5.2e-01 |
| 124 | Xbp1 | -1.40e-01 | 2.0e-01 | -6.00e-02 | 9.0e-01 | -1.60e-01 | 5.8e-01 | -1.19e+00 | 0.0e+00 | -4.70e-01 | 1.7e-01 | -2.30e-01 | 3.2e-01 |
| 46 | Hspb8 | 2.60e-01 | 1.1e-01 | 1.10e-01 | 8.2e-01 | 8.90e-01 | 0.0e+00 | -2.20e-01 | 4.3e-01 | -6.80e-01 | 1.0e-01 | -2.20e-01 | 5.6e-01 |
| 52 | Jak2 | 1.40e-01 | 4.8e-01 | -2.40e-01 | 2.0e-01 | -1.12e+00 | 0.0e+00 | 0.00e+00 | 1.0e+00 | 1.60e-01 | 6.3e-01 | -2.20e-01 | 3.0e-01 |
| 44 | Greb1 | -2.30e-01 | 6.0e-01 | -1.10e-01 | 7.9e-01 | -1.08e+00 | 0.0e+00 | -1.00e-01 | 9.4e-01 | 3.60e-01 | 2.8e-01 | -1.80e-01 | 5.5e-01 |
| 43 | Gja1 | 1.20e-01 | 3.9e-01 | -7.00e-02 | 8.3e-01 | -7.10e-01 | 4.0e-02 | -1.40e-01 | 8.2e-01 | 1.10e-01 | 7.8e-01 | -1.70e-01 | 3.8e-01 |
| 112 | Tgm2 | 8.00e-02 | 6.2e-01 | -1.00e-02 | 9.9e-01 | 1.84e+00 | 0.0e+00 | -2.80e-01 | 2.0e-01 | 9.10e-01 | 0.0e+00 | -1.10e-01 | 6.4e-01 |
| 66 | Muc1 | 8.00e-02 | 7.3e-01 | 1.00e-02 | 9.9e-01 | 1.05e+00 | 4.0e-02 | -2.80e-01 | 7.2e-01 | -4.40e-01 | 4.7e-01 | -1.00e-01 | NA |
| 64 | Mlph | 6.70e-01 | 0.0e+00 | 3.40e-01 | 3.9e-01 | 1.58e+00 | 0.0e+00 | 2.20e-01 | 8.2e-01 | 2.53e+00 | 0.0e+00 | -8.00e-02 | 9.2e-01 |
| 113 | Tiam1 | -4.30e-01 | 1.3e-01 | 1.00e-01 | 8.6e-01 | -1.01e+00 | 0.0e+00 | 4.00e-02 | 9.8e-01 | 5.40e-01 | 1.4e-01 | -7.00e-02 | 9.0e-01 |
| 48 | Il17rb | 2.00e-01 | 4.4e-01 | -7.00e-02 | 9.3e-01 | -2.20e-01 | 7.9e-01 | 1.21e+00 | 0.0e+00 | -1.10e-01 | NA | -5.00e-02 | NA |
| 120 | Ttc39a | 6.00e-02 | 9.0e-01 | -3.00e-02 | 9.7e-01 | -7.20e-01 | 0.0e+00 | -1.60e-01 | 8.7e-01 | 5.20e-01 | 3.4e-01 | -5.00e-02 | 9.2e-01 |
| 5 | Aqp3 | 2.68e+00 | 0.0e+00 | 2.00e-02 | NA | 7.30e-01 | 3.0e-02 | 1.00e-02 | NA | 1.80e-01 | NA | -3.00e-02 | NA |
| 110 | Tbc1d30 | 6.40e-01 | 1.0e-02 | -3.00e-01 | 4.5e-01 | 3.50e-01 | 5.1e-01 | 2.40e-01 | 7.9e-01 | 6.00e-02 | 9.5e-01 | -3.00e-02 | 9.7e-01 |
| 41 | Gab2 | 6.50e-01 | 0.0e+00 | 2.10e-01 | 5.9e-01 | 3.00e-01 | 2.2e-01 | 4.90e-01 | 3.1e-01 | 6.70e-01 | 0.0e+00 | -2.00e-02 | 9.7e-01 |
| 68 | Myc | 1.14e+00 | 0.0e+00 | -3.00e-02 | 9.7e-01 | 5.80e-01 | 0.0e+00 | -4.50e-01 | 3.8e-01 | 7.80e-01 | 0.0e+00 | 1.00e-02 | 9.7e-01 |
| 80 | Ppif | 1.70e-01 | 4.2e-01 | 2.10e-01 | 4.8e-01 | 6.70e-01 | 0.0e+00 | 7.40e-01 | 0.0e+00 | 1.40e-01 | 7.0e-01 | 4.00e-02 | 8.6e-01 |
| 96 | Sfn | 1.45e+00 | 0.0e+00 | 1.50e-01 | NA | 2.80e-01 | 7.0e-01 | 3.00e-01 | 7.2e-01 | 2.60e-01 | 5.9e-01 | 5.00e-02 | 9.5e-01 |
| 116 | Tob1 | 3.00e-02 | 9.1e-01 | -2.20e-01 | 5.5e-01 | -1.70e-01 | 5.7e-01 | 4.30e-01 | 1.5e-01 | -7.70e-01 | 1.0e-02 | 6.00e-02 | 8.1e-01 |
| 6 | Ar | -7.80e-01 | 2.0e-02 | -7.00e-02 | 9.3e-01 | -6.60e-01 | 1.4e-01 | -1.80e-01 | 8.7e-01 | -2.10e-01 | 7.4e-01 | 8.00e-02 | 8.5e-01 |
| 72 | Nrip1 | 7.00e-02 | 8.2e-01 | -1.20e-01 | 8.2e-01 | 2.80e-01 | 5.8e-01 | -6.60e-01 | 3.0e-02 | 4.80e-01 | 1.8e-01 | 8.00e-02 | 8.4e-01 |
| 11 | Bcl2 | -9.00e-02 | 8.4e-01 | -4.40e-01 | 2.8e-01 | -2.10e-01 | 7.3e-01 | -2.00e-02 | 9.9e-01 | -9.90e-01 | 1.0e-02 | 1.50e-01 | 8.3e-01 |
| 122 | Unc119 | -2.90e-01 | 1.5e-01 | 8.00e-02 | 8.6e-01 | -1.00e+00 | 0.0e+00 | -7.90e-01 | 0.0e+00 | -5.70e-01 | 1.4e-01 | 1.50e-01 | 7.5e-01 |
| 24 | Dhrs3 | 2.70e-01 | 1.5e-01 | 2.80e-01 | 4.9e-01 | -1.04e+00 | 0.0e+00 | -8.90e-01 | 0.0e+00 | -2.10e-01 | 6.5e-01 | 2.20e-01 | 4.0e-01 |
| 105 | Slc7a2 | -1.50e-01 | 7.4e-01 | -1.90e-01 | 7.5e-01 | -4.60e-01 | 3.6e-01 | 1.09e+00 | 0.0e+00 | 6.20e-01 | 1.2e-01 | 2.50e-01 | 5.1e-01 |
| 87 | Reep1 | 3.10e-01 | 6.0e-02 | -6.00e-02 | 9.2e-01 | -4.40e-01 | 1.9e-01 | -7.30e-01 | 5.0e-02 | -7.00e-01 | 1.0e-01 | 2.90e-01 | 4.0e-02 |
| 2 | Adcy9 | -5.00e-02 | 8.6e-01 | -1.50e-01 | 6.9e-01 | -2.10e-01 | 5.8e-01 | -6.70e-01 | 0.0e+00 | -4.30e-01 | 4.0e-02 | 4.40e-01 | 4.0e-02 |
| 106 | Slc7a5 | 8.90e-01 | 0.0e+00 | 1.50e-01 | 4.8e-01 | 6.20e-01 | 0.0e+00 | -8.00e-01 | 0.0e+00 | 2.04e+00 | 0.0e+00 | 4.40e-01 | 2.4e-01 |
| 108 | Stc2 | 2.80e-01 | 1.4e-01 | -3.10e-01 | 5.2e-01 | 1.14e+00 | 0.0e+00 | -2.20e-01 | NA | -4.00e-02 | 9.5e-01 | 4.40e-01 | 1.1e-01 |
| 60 | Lrig1 | 2.30e-01 | 1.0e-01 | -4.00e-02 | 8.9e-01 | -5.70e-01 | 1.0e-01 | -8.00e-01 | 0.0e+00 | -1.13e+00 | 0.0e+00 | 4.40e-01 | 5.0e-02 |
| 91 | Rrp12 | 4.50e-01 | 1.0e-02 | 1.40e-01 | 6.2e-01 | 5.90e-01 | 0.0e+00 | 8.40e-01 | 0.0e+00 | 7.00e-01 | 0.0e+00 | 4.50e-01 | 2.0e-02 |
| 62 | Med13l | 5.50e-01 | 0.0e+00 | -3.00e-02 | 9.6e-01 | 4.20e-01 | 1.1e-01 | 3.00e-01 | 5.2e-01 | 7.10e-01 | 0.0e+00 | 5.00e-01 | 0.0e+00 |
| 76 | Pdlim3 | -5.90e-01 | 0.0e+00 | 8.00e-02 | 9.1e-01 | -7.70e-01 | 4.0e-02 | -1.00e-01 | 9.4e-01 | -2.50e-01 | 7.2e-01 | 5.70e-01 | 2.0e-02 |
| 7 | Arl3 | -7.00e-02 | 8.3e-01 | 1.90e-01 | 6.1e-01 | 7.00e-02 | 8.7e-01 | -1.70e-01 | 7.7e-01 | 2.40e-01 | 5.2e-01 | 6.20e-01 | 2.0e-02 |
| 97 | Siah2 | 3.30e-01 | 1.8e-01 | 7.00e-02 | 8.9e-01 | 6.00e-02 | 9.2e-01 | -3.00e-02 | 9.6e-01 | 2.00e-02 | 9.8e-01 | 6.50e-01 | 0.0e+00 |
| 55 | Kdm4b | 3.30e-01 | 3.0e-02 | -3.00e-02 | 9.3e-01 | 6.00e-02 | 8.6e-01 | 2.50e-01 | 1.5e-01 | 0.00e+00 | 1.0e+00 | 6.80e-01 | 0.0e+00 |
| 109 | Sybu | 8.80e-01 | 0.0e+00 | 1.00e-02 | 9.9e-01 | -4.00e-02 | 9.4e-01 | 5.00e-02 | 9.4e-01 | 7.00e-01 | 1.0e-02 | 7.00e-01 | 4.0e-02 |
| 22 | Deptor | 3.00e-02 | 9.3e-01 | -7.00e-02 | 9.2e-01 | -1.05e+00 | 0.0e+00 | -5.00e-01 | 3.1e-01 | 5.40e-01 | 1.8e-01 | 7.90e-01 | 0.0e+00 |
| 78 | Pmaip1 | 9.70e-01 | 0.0e+00 | -1.10e-01 | 7.2e-01 | 4.80e-01 | 2.5e-01 | 6.70e-01 | 1.6e-01 | 1.19e+00 | 0.0e+00 | 8.00e-01 | 0.0e+00 |
| 71 | Ncor2 | 4.00e-02 | 7.6e-01 | -5.00e-02 | 9.0e-01 | -1.80e-01 | 2.7e-01 | 5.80e-01 | 0.0e+00 | 3.70e-01 | 1.3e-01 | 8.50e-01 | 0.0e+00 |
| 8 | Asb13 | -8.00e-02 | 8.5e-01 | -1.50e-01 | 7.8e-01 | -4.60e-01 | 1.6e-01 | 2.20e-01 | 4.3e-01 | -1.20e-01 | 7.6e-01 | 8.90e-01 | 0.0e+00 |
| 56 | Klf10 | 1.30e-01 | 4.3e-01 | -9.00e-02 | 8.6e-01 | 2.00e-02 | 9.2e-01 | 5.50e-01 | 3.0e-02 | 2.30e-01 | 5.6e-01 | 9.80e-01 | 0.0e+00 |
| 32 | Farp1 | -1.00e-02 | 9.6e-01 | 1.00e-01 | 7.5e-01 | -9.10e-01 | 0.0e+00 | -2.60e-01 | 2.9e-01 | -4.80e-01 | 4.0e-02 | 1.02e+00 | 0.0e+00 |
| 4 | Aff1 | 9.10e-01 | 0.0e+00 | 0.00e+00 | 1.0e+00 | -7.90e-01 | 1.0e-01 | -3.00e-02 | 9.9e-01 | 4.40e-01 | 3.0e-02 | 1.05e+00 | 0.0e+00 |
| 114 | Tiparp | 2.70e-01 | 1.9e-01 | 2.80e-01 | 4.8e-01 | 5.50e-01 | 1.9e-01 | -2.80e-01 | 5.9e-01 | 8.70e-01 | 0.0e+00 | 1.09e+00 | 0.0e+00 |
| 30 | Esrp2 | 2.90e-01 | 4.0e-02 | -1.00e-02 | 9.9e-01 | -2.80e-01 | 4.6e-01 | 3.00e-01 | 3.0e-02 | 9.30e-01 | 1.0e-02 | 1.21e+00 | 8.0e-02 |
| 61 | Mast4 | 1.10e-01 | 8.5e-01 | -6.50e-01 | 3.0e-02 | -2.08e+00 | 0.0e+00 | -6.00e-02 | NA | 4.00e-01 | 5.2e-01 | 1.24e+00 | 6.0e-02 |
| 51 | Itpk1 | 1.80e-01 | 5.0e-01 | 4.20e-01 | 3.0e-02 | 2.20e-01 | 6.6e-01 | 2.70e-01 | 3.9e-01 | 1.20e-01 | 7.5e-01 | 1.28e+00 | 0.0e+00 |
| 37 | Fkbp5 | 1.96e+00 | 0.0e+00 | 1.47e+00 | 0.0e+00 | 5.70e-01 | 0.0e+00 | 2.55e+00 | 0.0e+00 | 1.40e+00 | 0.0e+00 | 2.30e+00 | 0.0e+00 |
| 75 | Ovol2 | 7.70e-01 | 0.0e+00 | 7.00e-02 | NA | 4.00e-02 | NA | 8.00e-02 | NA | NA | NA | NA | NA |
| 82 | Rab17 | 9.50e-01 | 0.0e+00 | 2.10e-01 | NA | -2.90e-01 | 6.9e-01 | 4.50e-01 | 1.1e-01 | -5.00e-02 | NA | NA | NA |
EarlyEstrogen %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S22. Relative changes in the expression of genes involved in early estrogen response signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))TNFa%>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>%kable(caption = "Supplementary Table 23. Relative changes in the expression of genes involved in TNFa signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(TNFa$Adrenal_padj),F,ifelse(TNFa$Adrenal_padj<.1,T,F)),color= ifelse(is.na(TNFa$Adrenal_padj),"gray",ifelse(TNFa$Adrenal_padj<.1,spec_color(TNFa$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(TNFa$HT_padj),F,ifelse(TNFa$HT_padj<.1,T,F)),color= ifelse(is.na(TNFa$HT_padj),"gray",ifelse(TNFa$HT_padj<.1,spec_color(TNFa$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(TNFa$Liver_padj),F,ifelse(TNFa$Liver_padj<.1,T,F)),color= ifelse(is.na(TNFa$Liver_padj),"gray",ifelse(TNFa$Liver_padj<.1,spec_color(TNFa$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(TNFa$Lung_padj),F,ifelse(TNFa$Lung_padj<.1,T,F)),color= ifelse(is.na(TNFa$Lung_padj),"gray",ifelse(TNFa$Lung_padj <.1,spec_color(TNFa$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(TNFa$Adipose_padj),F,ifelse(TNFa$Adipose_padj<.1,T,F)),color= ifelse(is.na(TNFa$Adipose_padj),"gray",ifelse(TNFa$Adipose_padj<.1, spec_color(TNFa$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(TNFa$Muscle_padj),F,ifelse(TNFa$Muscle_padj<.1,T,F)),color= ifelse(is.na(TNFa$Muscle_padj),"gray",ifelse(TNFa$Muscle_padj<.1,spec_color(TNFa$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 44 | Egr2 | -2.00e-01 | 6.0e-01 | -9.00e-02 | 9.1e-01 | 1.05e+00 | 5.0e-02 | 3.80e-01 | 6.1e-01 | 3.30e-01 | NA | -2.62e+00 | 0.0e+00 |
| 19 | Ccnd1 | -5.70e-01 | 0.0e+00 | -8.80e-01 | 0.0e+00 | -7.20e-01 | 0.0e+00 | -1.03e+00 | 0.0e+00 | -8.20e-01 | 0.0e+00 | -2.57e+00 | 0.0e+00 |
| 70 | Inhba | -8.20e-01 | 3.0e-02 | -4.60e-01 | 2.5e-01 | -5.60e-01 | 3.6e-01 | -1.82e+00 | 0.0e+00 | -2.30e-01 | 7.6e-01 | -2.52e+00 | 0.0e+00 |
| 45 | Egr3 | -9.60e-01 | 1.0e-02 | 1.10e-01 | 8.8e-01 | 1.66e+00 | 0.0e+00 | -2.00e-02 | 9.9e-01 | -9.00e-02 | 9.2e-01 | -2.25e+00 | 0.0e+00 |
| 88 | Marcks | -5.00e-01 | 0.0e+00 | -1.80e-01 | 6.7e-01 | 1.60e-01 | 7.4e-01 | -4.10e-01 | 2.6e-01 | -3.90e-01 | 2.6e-01 | -2.17e+00 | 0.0e+00 |
| 137 | Tnc | 0.00e+00 | 9.9e-01 | -2.20e-01 | 5.8e-01 | 1.35e+00 | 0.0e+00 | -3.20e-01 | 6.5e-01 | 6.00e-02 | 9.2e-01 | -2.11e+00 | 0.0e+00 |
| 111 | Pmepa1 | 2.60e-01 | 2.0e-01 | 4.00e-02 | 9.6e-01 | 7.00e-01 | 7.0e-02 | 3.80e-01 | 5.1e-01 | 5.60e-01 | 5.0e-02 | -2.07e+00 | 0.0e+00 |
| 48 | F2rl1 | 7.80e-01 | 0.0e+00 | -3.50e-01 | 4.5e-01 | 5.00e-02 | 9.5e-01 | -3.80e-01 | 6.1e-01 | 2.80e-01 | 6.0e-01 | -2.04e+00 | 0.0e+00 |
| 3 | Atf3 | 6.90e-01 | 8.0e-02 | -3.70e-01 | 4.2e-01 | 1.40e-01 | 7.9e-01 | -8.40e-01 | 6.0e-02 | 3.70e-01 | 5.5e-01 | -2.01e+00 | 0.0e+00 |
| 63 | Ier3 | 1.09e+00 | 0.0e+00 | -6.00e-02 | 9.3e-01 | 1.01e+00 | 0.0e+00 | -4.40e-01 | 1.8e-01 | 1.00e-02 | 9.9e-01 | -1.95e+00 | 0.0e+00 |
| 16 | Ccl2 | 8.60e-01 | 2.0e-02 | -5.00e-02 | NA | -5.90e-01 | 3.0e-01 | -3.00e-02 | 9.9e-01 | -4.40e-01 | 4.6e-01 | -1.93e+00 | 0.0e+00 |
| 136 | Tlr2 | -5.10e-01 | 0.0e+00 | -7.60e-01 | 0.0e+00 | -1.06e+00 | 0.0e+00 | -4.00e-01 | 2.0e-01 | -9.30e-01 | 0.0e+00 | -1.90e+00 | 0.0e+00 |
| 146 | Trib1 | 7.50e-01 | 0.0e+00 | 3.80e-01 | 3.1e-01 | 9.50e-01 | 0.0e+00 | 3.10e-01 | 4.9e-01 | 7.00e-01 | 1.0e-02 | -1.75e+00 | 0.0e+00 |
| 43 | Egr1 | 5.80e-01 | 1.7e-01 | -5.70e-01 | 7.0e-02 | 5.70e-01 | 2.2e-01 | 1.90e-01 | 8.2e-01 | 4.50e-01 | 4.4e-01 | -1.72e+00 | 0.0e+00 |
| 23 | Cd83 | -7.30e-01 | 0.0e+00 | 6.00e-02 | 9.2e-01 | -8.00e-01 | 1.0e-02 | -3.00e-01 | 5.9e-01 | -6.50e-01 | 6.0e-02 | -1.69e+00 | 0.0e+00 |
| 59 | Gfpt2 | 7.70e-01 | 1.0e-02 | 3.30e-01 | 1.4e-01 | -6.00e-02 | 9.0e-01 | -4.20e-01 | 5.0e-01 | -4.80e-01 | 2.3e-01 | -1.61e+00 | 0.0e+00 |
| 9 | Bhlhe40 | 7.20e-01 | 0.0e+00 | 2.00e-01 | 5.5e-01 | 9.50e-01 | 0.0e+00 | -1.07e+00 | 0.0e+00 | -7.90e-01 | 1.0e-02 | -1.60e+00 | 0.0e+00 |
| 21 | Cd44 | -1.00e-01 | 5.0e-01 | 2.40e-01 | 5.1e-01 | 0.00e+00 | 1.0e+00 | -5.00e-02 | 9.8e-01 | -4.90e-01 | 2.0e-01 | -1.59e+00 | 0.0e+00 |
| 106 | Phlda1 | 2.00e-02 | 9.4e-01 | -4.40e-01 | 1.1e-01 | 4.30e-01 | 1.2e-01 | -2.10e-01 | 7.2e-01 | -1.80e-01 | 5.6e-01 | -1.57e+00 | 0.0e+00 |
| 31 | Cxcl10 | 6.60e-01 | 2.0e-02 | -3.80e-01 | 3.9e-01 | -2.06e+00 | 0.0e+00 | -2.00e-01 | 8.4e-01 | -7.90e-01 | 8.0e-02 | -1.54e+00 | 0.0e+00 |
| 1 | Abca1 | 2.40e-01 | 3.1e-01 | -2.60e-01 | 4.6e-01 | 1.00e-01 | 8.8e-01 | -3.90e-01 | 2.6e-01 | -5.40e-01 | 3.0e-02 | -1.54e+00 | 0.0e+00 |
| 14 | Btg2 | 6.00e-01 | 0.0e+00 | -1.20e-01 | 8.5e-01 | 3.00e-01 | 3.3e-01 | 8.90e-01 | 0.0e+00 | 7.60e-01 | 0.0e+00 | -1.53e+00 | 0.0e+00 |
| 61 | Icam1 | -1.40e-01 | 5.1e-01 | -3.40e-01 | 4.2e-01 | 5.90e-01 | 2.0e-02 | 4.10e-01 | 6.0e-02 | -5.00e-02 | 9.2e-01 | -1.50e+00 | 0.0e+00 |
| 130 | Socs3 | 1.12e+00 | 0.0e+00 | 4.00e-02 | 9.7e-01 | -1.30e-01 | 8.3e-01 | -2.50e-01 | 6.5e-01 | 1.70e-01 | NA | -1.49e+00 | 0.0e+00 |
| 114 | Ptgs2 | 9.50e-01 | 0.0e+00 | -3.40e-01 | 2.8e-01 | 4.20e-01 | 3.8e-01 | -2.60e-01 | 7.7e-01 | 4.00e-01 | 5.2e-01 | -1.49e+00 | 0.0e+00 |
| 49 | F3 | 1.20e+00 | 0.0e+00 | 1.90e-01 | 7.0e-01 | 1.40e-01 | 7.1e-01 | 6.10e-01 | 1.9e-01 | 7.00e-02 | 8.7e-01 | -1.49e+00 | 0.0e+00 |
| 98 | Nr4a2 | 1.10e-01 | 7.7e-01 | -1.70e-01 | 7.6e-01 | -1.10e+00 | 1.0e-02 | -1.42e+00 | 0.0e+00 | 1.60e-01 | 7.4e-01 | -1.40e+00 | 0.0e+00 |
| 78 | Klf6 | 4.60e-01 | 0.0e+00 | -2.70e-01 | 4.1e-01 | -3.60e-01 | 2.5e-01 | -1.80e-01 | 7.9e-01 | 5.90e-01 | 4.0e-02 | -1.32e+00 | 0.0e+00 |
| 20 | Ccrl2 | -1.50e-01 | 5.1e-01 | -3.20e-01 | 5.1e-01 | -1.06e+00 | 3.0e-02 | -5.00e-01 | 3.7e-01 | -1.40e-01 | 8.2e-01 | -1.27e+00 | 0.0e+00 |
| 29 | Csf1 | 1.00e-02 | 9.8e-01 | -1.80e-01 | 4.4e-01 | -5.10e-01 | 1.0e-02 | -5.50e-01 | 0.0e+00 | -3.00e-01 | 3.3e-01 | -1.26e+00 | 0.0e+00 |
| 116 | Rcan1 | 7.90e-01 | 0.0e+00 | 6.00e-02 | 9.2e-01 | -1.60e-01 | 4.4e-01 | -1.21e+00 | 0.0e+00 | -2.20e-01 | 3.9e-01 | -1.23e+00 | 0.0e+00 |
| 120 | Ripk2 | -4.00e-02 | 8.3e-01 | 1.90e-01 | 4.8e-01 | -1.60e-01 | 6.6e-01 | 2.10e-01 | 4.6e-01 | -1.00e-02 | 9.9e-01 | -1.22e+00 | 0.0e+00 |
| 15 | Btg3 | 4.50e-01 | 0.0e+00 | 2.70e-01 | 2.3e-01 | 1.17e+00 | 0.0e+00 | 2.50e-01 | 6.6e-01 | 4.90e-01 | 3.0e-02 | -1.18e+00 | 0.0e+00 |
| 101 | Panx1 | 1.20e-01 | 5.1e-01 | 7.00e-02 | 8.3e-01 | 3.60e-01 | 1.2e-01 | -9.00e-02 | 7.6e-01 | -4.90e-01 | 1.4e-01 | -1.17e+00 | 0.0e+00 |
| 77 | Klf4 | 1.30e-01 | 6.2e-01 | -3.00e-02 | 9.7e-01 | 7.40e-01 | 0.0e+00 | -3.00e-02 | 9.8e-01 | 1.23e+00 | 0.0e+00 | -1.16e+00 | 0.0e+00 |
| 39 | Dusp1 | 1.14e+00 | 0.0e+00 | 8.00e-02 | 9.1e-01 | 1.10e+00 | 0.0e+00 | -5.60e-01 | 1.3e-01 | 6.80e-01 | 1.0e-01 | -1.15e+00 | 0.0e+00 |
| 109 | Plk2 | 2.60e-01 | 1.6e-01 | 1.00e-02 | 9.9e-01 | 1.90e-01 | 5.1e-01 | -4.90e-01 | 0.0e+00 | -6.30e-01 | 2.0e-02 | -1.14e+00 | 0.0e+00 |
| 6 | Bcl2a1 | -6.10e-01 | 0.0e+00 | -4.70e-01 | 2.4e-01 | -5.10e-01 | 3.1e-01 | -6.60e-01 | 1.3e-01 | -4.10e-01 | 3.6e-01 | -1.14e+00 | 2.0e-02 |
| 125 | Serpinb8 | 4.60e-01 | 1.0e-02 | -6.00e-02 | NA | 4.70e-01 | 4.8e-01 | -6.80e-01 | 1.0e-02 | 1.90e-01 | 7.9e-01 | -1.13e+00 | 6.0e-02 |
| 38 | Dram1 | 3.50e-01 | 0.0e+00 | -4.70e-01 | 2.3e-01 | 5.70e-01 | 1.0e-02 | -1.90e-01 | 8.3e-01 | -2.00e-01 | 4.0e-01 | -1.12e+00 | 0.0e+00 |
| 5 | B4galt5 | 4.40e-01 | 0.0e+00 | -1.70e-01 | 2.6e-01 | -8.30e-01 | 0.0e+00 | -3.80e-01 | 5.0e-02 | -5.00e-01 | 2.0e-01 | -1.10e+00 | 0.0e+00 |
| 62 | Id2 | 1.80e-01 | 9.0e-02 | 1.04e+00 | 0.0e+00 | 5.50e-01 | 3.0e-02 | -7.60e-01 | 0.0e+00 | 2.70e-01 | 6.6e-01 | -1.08e+00 | 0.0e+00 |
| 73 | Jag1 | 2.00e-01 | 2.5e-01 | -5.60e-01 | 5.0e-02 | 2.80e-01 | 2.7e-01 | -5.60e-01 | 2.0e-01 | 1.20e-01 | 7.5e-01 | -1.07e+00 | 0.0e+00 |
| 140 | Tnfaip6 | 9.40e-01 | 0.0e+00 | 3.60e-01 | 3.6e-01 | -5.30e-01 | 2.9e-01 | 1.30e-01 | NA | 4.40e-01 | 1.4e-01 | -1.04e+00 | 0.0e+00 |
| 57 | Gch1 | -1.80e-01 | 4.0e-01 | 1.00e-02 | 9.9e-01 | 7.30e-01 | 2.0e-02 | -1.80e-01 | 3.0e-01 | -5.50e-01 | 2.5e-01 | -1.03e+00 | 2.0e-02 |
| 91 | Nfat5 | -1.90e-01 | 5.6e-01 | -2.20e-01 | 6.5e-01 | -3.30e-01 | 5.3e-01 | -2.70e-01 | 6.5e-01 | -2.50e-01 | 4.8e-01 | -1.01e+00 | 0.0e+00 |
| 72 | Irs2 | 2.70e-01 | 1.0e-02 | -5.00e-02 | 8.9e-01 | -2.10e-01 | 6.9e-01 | 2.20e-01 | 6.7e-01 | -9.20e-01 | 0.0e+00 | -1.00e+00 | 0.0e+00 |
| 41 | Edn1 | 1.10e+00 | 0.0e+00 | 1.00e-01 | 8.7e-01 | 5.10e-01 | 2.7e-01 | -2.60e-01 | 7.6e-01 | -3.00e-02 | 9.7e-01 | -9.50e-01 | 2.0e-02 |
| 37 | Dnajb4 | 2.30e-01 | 1.0e-02 | 1.00e-02 | 9.9e-01 | -4.70e-01 | 2.3e-01 | 3.90e-01 | 1.1e-01 | 5.50e-01 | 2.0e-02 | -9.20e-01 | 1.0e-02 |
| 110 | Plpp3 | -1.80e-01 | 1.3e-01 | -1.50e-01 | 5.2e-01 | 9.60e-01 | 0.0e+00 | 2.10e-01 | 3.2e-01 | 2.00e-02 | 9.6e-01 | -9.20e-01 | 0.0e+00 |
| 108 | Plek | -2.20e-01 | 2.8e-01 | -7.50e-01 | 0.0e+00 | -9.00e-02 | 8.4e-01 | -4.90e-01 | 2.1e-01 | 7.50e-01 | 0.0e+00 | -8.80e-01 | 0.0e+00 |
| 60 | Gpr183 | -3.10e-01 | 2.4e-01 | 1.20e-01 | 8.6e-01 | 1.70e-01 | 7.1e-01 | -3.60e-01 | 6.1e-01 | 6.00e-02 | 9.4e-01 | -8.80e-01 | 5.0e-02 |
| 2 | Ackr3 | 4.10e-01 | 0.0e+00 | 0.00e+00 | 1.0e+00 | 6.90e-01 | 0.0e+00 | -2.50e-01 | 7.5e-01 | 7.00e-02 | 9.2e-01 | -8.40e-01 | 0.0e+00 |
| 7 | Bcl3 | 4.70e-01 | 1.1e-01 | 2.90e-01 | 5.6e-01 | -8.70e-01 | 0.0e+00 | 1.32e+00 | 0.0e+00 | -4.70e-01 | 2.7e-01 | -8.40e-01 | 6.0e-02 |
| 138 | Tnfaip2 | -4.00e-02 | 9.2e-01 | 1.00e-01 | 8.7e-01 | -3.70e-01 | 9.0e-02 | -4.10e-01 | 1.5e-01 | -2.90e-01 | 4.1e-01 | -7.90e-01 | 0.0e+00 |
| 117 | Rel | -2.10e-01 | 5.0e-01 | -3.90e-01 | 3.4e-01 | -3.60e-01 | 5.1e-01 | 1.90e-01 | 7.8e-01 | 4.10e-01 | 3.4e-01 | -7.80e-01 | 1.0e-02 |
| 64 | Ier5 | 5.00e-02 | 8.5e-01 | 0.00e+00 | 1.0e+00 | -2.10e-01 | 3.8e-01 | -4.10e-01 | 1.9e-01 | -1.70e-01 | 7.8e-01 | -7.70e-01 | 2.0e-02 |
| 13 | Btg1 | 4.70e-01 | 1.0e-02 | -2.00e-02 | 9.8e-01 | -3.10e-01 | 5.6e-01 | 6.00e-02 | 9.4e-01 | 6.20e-01 | 0.0e+00 | -7.70e-01 | 0.0e+00 |
| 141 | Tnfaip8 | 6.00e-02 | 7.7e-01 | -1.40e-01 | 7.5e-01 | -5.00e-02 | 9.2e-01 | 3.60e-01 | 4.3e-01 | -4.00e-02 | 9.5e-01 | -7.70e-01 | 1.0e-02 |
| 84 | Litaf | 4.60e-01 | 0.0e+00 | 2.30e-01 | 3.3e-01 | 5.20e-01 | 0.0e+00 | -6.00e-02 | 8.9e-01 | 3.00e-02 | 9.4e-01 | -7.60e-01 | 0.0e+00 |
| 51 | Fos | 1.01e+00 | 0.0e+00 | -6.40e-01 | 1.0e-02 | 4.60e-01 | 3.1e-01 | 3.90e-01 | 6.0e-01 | 3.20e-01 | NA | -7.50e-01 | 2.4e-01 |
| 4 | B4galt1 | 3.30e-01 | 0.0e+00 | -4.40e-01 | 1.2e-01 | -3.90e-01 | 9.0e-02 | -3.30e-01 | 8.0e-02 | -2.40e-01 | 4.9e-01 | -7.20e-01 | 0.0e+00 |
| 92 | Nfe2l2 | -1.60e-01 | 4.0e-01 | -6.00e-02 | 9.0e-01 | -2.00e-01 | 3.7e-01 | -1.39e+00 | 0.0e+00 | 1.00e-01 | 7.2e-01 | -6.90e-01 | 0.0e+00 |
| 65 | Ifih1 | -3.60e-01 | 5.0e-02 | -1.10e-01 | 8.3e-01 | -6.90e-01 | 2.0e-02 | -2.00e-01 | 7.0e-01 | 1.70e-01 | 7.6e-01 | -6.80e-01 | 0.0e+00 |
| 54 | G0s2 | -1.41e+00 | 0.0e+00 | -3.20e-01 | 5.0e-01 | 3.30e-01 | 5.5e-01 | 4.80e-01 | 2.6e-01 | 3.10e-01 | 5.2e-01 | -6.60e-01 | 8.0e-02 |
| 71 | Irf1 | -1.70e-01 | 4.5e-01 | -2.00e-01 | 6.0e-01 | -1.00e+00 | 0.0e+00 | -6.40e-01 | 1.0e-02 | -6.40e-01 | 0.0e+00 | -6.20e-01 | 0.0e+00 |
| 96 | Ninj1 | 4.80e-01 | 0.0e+00 | 1.00e-02 | 9.9e-01 | 5.10e-01 | 0.0e+00 | -2.30e-01 | 3.9e-01 | -1.10e-01 | 8.2e-01 | -6.10e-01 | 7.0e-02 |
| 52 | Fosl1 | 9.90e-01 | 0.0e+00 | 4.60e-01 | 1.6e-01 | 2.33e+00 | 0.0e+00 | 3.80e-01 | NA | -8.00e-02 | 9.1e-01 | -6.10e-01 | 2.5e-01 |
| 17 | Ccl4 | -7.60e-01 | 0.0e+00 | -1.90e-01 | NA | -5.30e-01 | 2.9e-01 | -4.10e-01 | 3.6e-01 | -7.60e-01 | 9.0e-02 | -5.50e-01 | NA |
| 74 | Jun | 4.20e-01 | 6.0e-02 | -3.60e-01 | 2.2e-01 | -7.30e-01 | 0.0e+00 | -9.30e-01 | 2.0e-02 | 6.40e-01 | 8.0e-02 | -5.30e-01 | 2.0e-02 |
| 80 | Kynu | -1.08e+00 | 0.0e+00 | -2.00e-02 | 9.8e-01 | -4.90e-01 | 4.1e-01 | -2.30e-01 | 1.3e-01 | 4.00e-02 | NA | -5.10e-01 | NA |
| 128 | Sik1 | 1.35e+00 | 0.0e+00 | 8.00e-02 | 8.3e-01 | 4.20e-01 | 3.3e-01 | 1.30e-01 | 8.8e-01 | 5.20e-01 | 1.6e-01 | -5.10e-01 | 1.3e-01 |
| 113 | Ppp1r15a | 7.40e-01 | 0.0e+00 | 3.30e-01 | 2.5e-01 | 2.80e-01 | 4.6e-01 | -8.00e-02 | 9.3e-01 | 8.40e-01 | 1.0e-02 | -4.90e-01 | 9.0e-02 |
| 107 | Plaur | 1.33e+00 | 0.0e+00 | -1.60e-01 | NA | 4.30e-01 | 1.8e-01 | 4.30e-01 | 5.1e-01 | 1.50e-01 | 6.9e-01 | -4.70e-01 | 2.8e-01 |
| 36 | Ddx58 | -5.90e-01 | 0.0e+00 | -5.40e-01 | 4.0e-02 | -1.31e+00 | 0.0e+00 | -2.50e-01 | 6.3e-01 | -4.40e-01 | 1.9e-01 | -4.50e-01 | 9.0e-02 |
| 134 | Tap1 | -1.40e-01 | 4.8e-01 | -7.00e-02 | 9.2e-01 | -3.70e-01 | 3.5e-01 | -4.20e-01 | 1.0e-01 | -7.30e-01 | 1.0e-02 | -4.10e-01 | 6.0e-02 |
| 129 | Slc16a6 | -3.20e-01 | 1.7e-01 | -5.40e-01 | 3.0e-02 | 5.00e-02 | 8.9e-01 | 1.66e+00 | 0.0e+00 | -3.80e-01 | 3.0e-01 | -3.90e-01 | 1.2e-01 |
| 68 | Il18 | 2.70e-01 | 2.4e-01 | -1.70e-01 | 7.3e-01 | 7.30e-01 | 0.0e+00 | 2.70e-01 | 3.7e-01 | 2.70e-01 | 6.0e-01 | -3.90e-01 | 4.9e-01 |
| 90 | Nampt | 4.80e-01 | 0.0e+00 | 9.00e-02 | 8.6e-01 | 4.90e-01 | 2.8e-01 | -1.00e-02 | 9.9e-01 | 6.00e-01 | 6.0e-02 | -3.50e-01 | 4.0e-02 |
| 12 | Bmp2 | 5.90e-01 | 0.0e+00 | -2.00e-01 | 6.2e-01 | -2.70e-01 | 2.1e-01 | -3.80e-01 | 1.7e-01 | 1.50e-01 | 7.0e-01 | -3.30e-01 | 3.2e-01 |
| 124 | Serpinb2 | 3.00e-02 | NA | -1.00e-02 | NA | 1.71e+00 | 0.0e+00 | NA | NA | -4.00e-02 | NA | -3.30e-01 | NA |
| 28 | Clcf1 | 9.00e-02 | 8.1e-01 | -1.60e-01 | NA | 1.90e-01 | 5.2e-01 | 9.70e-01 | 0.0e+00 | -1.90e-01 | 7.6e-01 | -3.10e-01 | 5.7e-01 |
| 42 | Efna1 | 2.60e-01 | 2.6e-01 | 4.00e-02 | 9.5e-01 | -1.20e-01 | 8.1e-01 | -7.60e-01 | 1.0e-02 | 8.00e-02 | 9.0e-01 | -3.00e-01 | 1.7e-01 |
| 139 | Tnfaip3 | 2.10e-01 | 5.3e-01 | -2.20e-01 | 6.7e-01 | -2.70e-01 | 4.6e-01 | 7.90e-01 | 2.0e-02 | -3.30e-01 | 4.4e-01 | -3.00e-01 | 4.5e-01 |
| 112 | Pnrc1 | 3.50e-01 | 1.0e-02 | -6.00e-02 | 8.9e-01 | 7.00e-01 | 0.0e+00 | 4.00e-02 | 9.3e-01 | 3.70e-01 | 1.6e-01 | -1.80e-01 | 4.1e-01 |
| 10 | Birc2 | 2.00e-01 | 8.0e-02 | 1.00e-01 | 8.0e-01 | -9.20e-01 | 0.0e+00 | -8.10e-01 | 0.0e+00 | 2.00e-01 | 3.0e-01 | -1.50e-01 | 4.1e-01 |
| 82 | Ldlr | 3.30e-01 | 0.0e+00 | 3.20e-01 | 8.0e-02 | 5.00e-02 | 8.7e-01 | -6.60e-01 | 0.0e+00 | -4.00e-02 | 9.5e-01 | -1.30e-01 | 7.4e-01 |
| 22 | Cd69 | -7.40e-01 | 0.0e+00 | -3.00e-02 | NA | 6.00e-02 | 9.4e-01 | -2.80e-01 | 7.3e-01 | -6.00e-02 | 9.5e-01 | -1.20e-01 | 8.8e-01 |
| 149 | Yrdc | 4.20e-01 | 0.0e+00 | 3.40e-01 | 1.0e-02 | 8.00e-01 | 0.0e+00 | 1.10e-01 | 8.0e-01 | 2.10e-01 | 5.4e-01 | -9.00e-02 | 7.9e-01 |
| 83 | Lif | 7.10e-01 | 3.0e-02 | -1.20e-01 | NA | 6.90e-01 | NA | 0.00e+00 | NA | 1.90e-01 | 8.1e-01 | -8.00e-02 | 9.3e-01 |
| 145 | Traf1 | -3.80e-01 | 1.0e-01 | -3.30e-01 | 4.9e-01 | -1.19e+00 | 0.0e+00 | -2.50e-01 | 7.1e-01 | -6.80e-01 | 2.0e-02 | -7.00e-02 | 9.0e-01 |
| 148 | Tubb2a | 4.20e-01 | 3.0e-02 | 2.10e-01 | 5.4e-01 | 7.00e-01 | 0.0e+00 | -5.00e-02 | 9.5e-01 | 4.70e-01 | 7.0e-02 | -4.00e-02 | 8.9e-01 |
| 133 | Stat5a | -3.40e-01 | 0.0e+00 | -5.00e-02 | 9.0e-01 | -1.20e-01 | 6.2e-01 | -3.80e-01 | 1.2e-01 | -1.23e+00 | 0.0e+00 | -4.00e-02 | 8.9e-01 |
| 66 | Il12b | -7.10e-01 | 1.0e-01 | 1.00e-02 | NA | -3.00e-02 | NA | 1.10e-01 | NA | -2.60e-01 | NA | -2.00e-02 | NA |
| 58 | Gem | 1.29e+00 | 0.0e+00 | -2.00e-02 | 9.8e-01 | 1.08e+00 | 0.0e+00 | 5.30e-01 | 3.4e-01 | 3.50e-01 | 5.8e-01 | -1.00e-02 | 9.7e-01 |
| 89 | Myc | 1.14e+00 | 0.0e+00 | -3.00e-02 | 9.7e-01 | 5.80e-01 | 0.0e+00 | -4.50e-01 | 3.8e-01 | 7.80e-01 | 0.0e+00 | 1.00e-02 | 9.7e-01 |
| 50 | Fjx1 | 7.30e-01 | 0.0e+00 | 1.00e-02 | 9.9e-01 | 1.32e+00 | 0.0e+00 | 2.90e-01 | NA | 4.50e-01 | 3.7e-01 | 3.00e-02 | 9.6e-01 |
| 142 | Tnfsf9 | 1.33e+00 | 0.0e+00 | -2.30e-01 | 6.7e-01 | -4.00e-02 | NA | -7.00e-02 | NA | 3.30e-01 | 5.3e-01 | 3.00e-02 | 9.7e-01 |
| 35 | Cxcl6 | 1.48e+00 | 0.0e+00 | -2.70e-01 | 5.8e-01 | -3.00e-02 | NA | 1.90e-01 | NA | -2.40e-01 | NA | 4.00e-02 | NA |
| 30 | Cxcl1 | 1.85e+00 | 0.0e+00 | -1.00e-02 | NA | 2.00e-01 | NA | 1.30e-01 | 9.1e-01 | 7.00e-02 | 9.3e-01 | 9.00e-02 | NA |
| 32 | Cxcl11 | -3.00e-02 | 9.7e-01 | 1.00e-01 | NA | -1.01e+00 | 7.0e-02 | -1.21e+00 | 0.0e+00 | -9.60e-01 | 1.0e-02 | 1.00e-01 | 8.8e-01 |
| 87 | Map3k8 | 8.70e-01 | 0.0e+00 | 1.60e-01 | 7.8e-01 | 6.00e-02 | 9.2e-01 | 1.40e-01 | 8.1e-01 | 1.20e-01 | 7.5e-01 | 1.10e-01 | 6.9e-01 |
| 122 | Sat1 | 9.60e-01 | 0.0e+00 | 2.40e-01 | 5.0e-01 | 5.60e-01 | 4.0e-02 | 1.50e-01 | 7.3e-01 | 6.50e-01 | 5.0e-02 | 1.10e-01 | 7.0e-01 |
| 47 | Eif1 | 3.60e-01 | 1.0e-02 | 2.10e-01 | 5.6e-01 | 6.80e-01 | 0.0e+00 | 2.00e-01 | 6.2e-01 | 2.00e-01 | 3.1e-01 | 1.20e-01 | 6.6e-01 |
| 27 | Cflar | 3.60e-01 | 7.0e-02 | 1.00e-02 | 9.9e-01 | 5.70e-01 | 0.0e+00 | 3.30e-01 | 3.7e-01 | 6.50e-01 | 1.0e-02 | 1.40e-01 | 5.3e-01 |
| 33 | Cxcl2 | 2.74e+00 | 0.0e+00 | 5.20e-01 | NA | 3.50e-01 | NA | 1.20e-01 | NA | 2.60e-01 | NA | 1.60e-01 | NA |
| 102 | Pde4b | 4.00e-01 | 7.0e-02 | -3.00e-02 | 9.5e-01 | 1.32e+00 | 0.0e+00 | 1.00e-01 | 9.2e-01 | -9.00e-02 | 8.6e-01 | 1.80e-01 | 6.1e-01 |
| 118 | Relb | 1.30e-01 | 7.5e-01 | -1.50e-01 | 7.7e-01 | -3.90e-01 | 7.0e-02 | -3.20e-01 | 6.2e-01 | -1.13e+00 | 0.0e+00 | 2.00e-01 | 5.3e-01 |
| 75 | Junb | 1.14e+00 | 0.0e+00 | -2.20e-01 | 5.5e-01 | -7.00e-02 | 9.0e-01 | -2.00e-02 | 9.8e-01 | 3.10e-01 | 6.5e-01 | 2.10e-01 | 5.2e-01 |
| 94 | Nfkb2 | 2.60e-01 | 1.7e-01 | -4.70e-01 | 1.5e-01 | -1.90e-01 | 5.9e-01 | -8.00e-02 | 8.6e-01 | -7.60e-01 | 0.0e+00 | 2.10e-01 | 2.5e-01 |
| 25 | Cebpb | 3.50e-01 | 1.2e-01 | 4.50e-01 | 1.9e-01 | 7.00e-02 | 8.5e-01 | 7.00e-01 | 0.0e+00 | 2.60e-01 | 5.8e-01 | 2.10e-01 | 5.9e-01 |
| 147 | Tsc22d1 | 2.40e-01 | 7.0e-02 | -1.00e-02 | 9.9e-01 | -6.20e-01 | 0.0e+00 | -8.70e-01 | 0.0e+00 | 9.20e-01 | 0.0e+00 | 2.20e-01 | 1.7e-01 |
| 132 | Spsb1 | 1.02e+00 | 0.0e+00 | 8.60e-01 | 0.0e+00 | 5.40e-01 | 9.0e-02 | 2.69e+00 | 0.0e+00 | 1.43e+00 | 0.0e+00 | 2.40e-01 | 4.8e-01 |
| 46 | Ehd1 | -3.00e-02 | 9.0e-01 | -5.00e-02 | 9.3e-01 | 1.05e+00 | 0.0e+00 | 2.30e-01 | 2.1e-01 | 5.30e-01 | 0.0e+00 | 2.80e-01 | 5.0e-02 |
| 86 | Map2k3 | 3.90e-01 | 3.0e-02 | -1.40e-01 | 8.2e-01 | -7.50e-01 | 0.0e+00 | -1.90e-01 | 3.1e-01 | -4.40e-01 | 9.0e-02 | 3.00e-01 | 1.0e-01 |
| 119 | Rhob | 9.00e-02 | 7.2e-01 | 4.50e-01 | 0.0e+00 | -5.00e-02 | 8.6e-01 | 6.30e-01 | 0.0e+00 | 4.20e-01 | 0.0e+00 | 3.80e-01 | 2.0e-01 |
| 81 | Lamb3 | 2.70e-01 | 1.0e-01 | 3.00e-02 | 9.8e-01 | 1.09e+00 | 4.0e-02 | 4.90e-01 | 3.6e-01 | -1.20e-01 | 8.9e-01 | 3.90e-01 | 3.2e-01 |
| 53 | Fosl2 | 1.14e+00 | 0.0e+00 | -1.80e-01 | 7.7e-01 | -3.80e-01 | 3.1e-01 | 3.00e-01 | 7.2e-01 | 4.00e-01 | 4.2e-01 | 4.40e-01 | 2.2e-01 |
| 103 | Pdlim5 | -3.00e-02 | 9.5e-01 | -2.50e-01 | 5.6e-01 | -7.20e-01 | 1.0e-02 | 1.30e-01 | 8.6e-01 | 3.90e-01 | 1.1e-01 | 4.70e-01 | 1.0e-02 |
| 150 | Zc3h12a | 7.80e-01 | 0.0e+00 | -4.00e-02 | 9.6e-01 | 2.40e-01 | 4.9e-01 | 8.00e-01 | 0.0e+00 | 7.00e-02 | 9.1e-01 | 4.90e-01 | 8.0e-02 |
| 143 | Tnip1 | 1.10e-01 | 7.8e-01 | -2.00e-02 | 9.8e-01 | 6.70e-01 | 0.0e+00 | 5.00e-02 | 9.4e-01 | -5.00e-02 | 9.0e-01 | 5.10e-01 | 0.0e+00 |
| 18 | Ccl5 | -2.40e-01 | 2.0e-01 | 3.20e-01 | 4.9e-01 | 7.40e-01 | 4.0e-02 | -3.80e-01 | 4.7e-01 | -3.90e-01 | 2.5e-01 | 5.30e-01 | 3.3e-01 |
| 95 | Nfkbia | 1.12e+00 | 0.0e+00 | 7.30e-01 | 0.0e+00 | -1.70e-01 | 6.1e-01 | 2.50e-01 | 2.9e-01 | 9.00e-01 | 0.0e+00 | 5.90e-01 | 4.0e-02 |
| 126 | Serpine1 | 8.00e-01 | 0.0e+00 | 1.60e-01 | 7.8e-01 | -1.21e+00 | 0.0e+00 | 1.34e+00 | 0.0e+00 | 4.53e+00 | 0.0e+00 | 6.40e-01 | 3.0e-02 |
| 115 | Ptx3 | 1.20e+00 | 0.0e+00 | 2.60e-01 | NA | 5.00e-02 | 9.6e-01 | -1.00e-01 | NA | -2.10e-01 | 7.8e-01 | 6.50e-01 | 9.0e-02 |
| 127 | Sgk1 | 5.00e-01 | 0.0e+00 | 7.60e-01 | 1.0e-02 | 1.90e-01 | 5.3e-01 | -2.60e-01 | 6.2e-01 | 9.60e-01 | 0.0e+00 | 7.00e-01 | 0.0e+00 |
| 85 | Maff | 1.35e+00 | 0.0e+00 | 3.00e-01 | 4.7e-01 | 1.77e+00 | 0.0e+00 | 6.00e-02 | 9.6e-01 | 9.40e-01 | 0.0e+00 | 7.60e-01 | 7.0e-02 |
| 11 | Birc3 | 2.20e-01 | 5.0e-01 | 1.10e-01 | 8.8e-01 | 4.70e-01 | 1.8e-01 | 7.50e-01 | 0.0e+00 | 6.50e-01 | 1.0e-02 | 7.70e-01 | 1.0e-02 |
| 123 | Sdc4 | 6.80e-01 | 0.0e+00 | 2.70e-01 | 4.9e-01 | 4.00e-01 | 2.4e-01 | 1.09e+00 | 0.0e+00 | 7.60e-01 | 7.0e-02 | 8.10e-01 | 0.0e+00 |
| 144 | Tnip2 | 1.10e-01 | 7.7e-01 | 1.90e-01 | 6.5e-01 | -4.90e-01 | 1.7e-01 | 3.80e-01 | 3.5e-01 | -1.30e-01 | 8.0e-01 | 9.10e-01 | 0.0e+00 |
| 76 | Klf10 | 1.30e-01 | 4.3e-01 | -9.00e-02 | 8.6e-01 | 2.00e-02 | 9.2e-01 | 5.50e-01 | 3.0e-02 | 2.30e-01 | 5.6e-01 | 9.80e-01 | 0.0e+00 |
| 79 | Klf9 | 3.50e-01 | 3.5e-01 | 4.60e-01 | 2.0e-01 | -3.00e-02 | 9.5e-01 | 6.40e-01 | 6.0e-02 | 5.00e-01 | 0.0e+00 | 1.02e+00 | 0.0e+00 |
| 55 | Gadd45a | 7.00e-01 | 0.0e+00 | 1.10e-01 | 7.9e-01 | 6.30e-01 | 2.0e-02 | 3.70e-01 | 1.8e-01 | -8.70e-01 | 0.0e+00 | 1.07e+00 | 0.0e+00 |
| 135 | Tiparp | 2.70e-01 | 1.9e-01 | 2.80e-01 | 4.8e-01 | 5.50e-01 | 1.9e-01 | -2.80e-01 | 5.9e-01 | 8.70e-01 | 0.0e+00 | 1.09e+00 | 0.0e+00 |
| 121 | Rnf19b | 1.00e-01 | 7.5e-01 | 2.50e-01 | 4.6e-01 | -4.50e-01 | 2.9e-01 | -7.00e-02 | 9.2e-01 | -5.60e-01 | 4.0e-02 | 1.09e+00 | 0.0e+00 |
| 40 | Dusp5 | 2.70e-01 | 3.2e-01 | 2.60e-01 | 6.0e-01 | 1.08e+00 | 0.0e+00 | -4.40e-01 | 1.3e-01 | 1.90e-01 | 7.2e-01 | 1.13e+00 | 0.0e+00 |
| 67 | Il15ra | -1.50e-01 | 7.2e-01 | 3.10e-01 | 5.3e-01 | 6.30e-01 | 1.0e-02 | 7.70e-01 | 0.0e+00 | -3.80e-01 | 4.7e-01 | 1.19e+00 | 0.0e+00 |
| 131 | Sphk1 | 2.18e+00 | 0.0e+00 | -1.10e-01 | 8.7e-01 | -4.50e-01 | 3.0e-02 | 1.60e-01 | 8.8e-01 | 1.12e+00 | 0.0e+00 | 1.30e+00 | 1.0e-02 |
| 99 | Nr4a3 | 5.40e-01 | 1.2e-01 | -4.30e-01 | 3.0e-01 | -2.30e+00 | 0.0e+00 | -9.00e-02 | 9.4e-01 | 3.30e-01 | 6.0e-01 | 1.36e+00 | 3.0e-02 |
| 26 | Cebpd | 1.32e+00 | 0.0e+00 | 4.90e-01 | 1.7e-01 | 6.00e-02 | 9.0e-01 | 1.00e-02 | 9.9e-01 | 8.40e-01 | 3.0e-02 | 1.42e+00 | 0.0e+00 |
| 151 | Zfp36 | 9.40e-01 | 0.0e+00 | 3.70e-01 | 2.6e-01 | -1.50e-01 | 6.9e-01 | 3.30e-01 | 3.4e-01 | 8.20e-01 | 5.0e-02 | 1.46e+00 | 0.0e+00 |
| 100 | Olr1 | 6.00e-02 | 7.6e-01 | 2.00e-02 | 9.8e-01 | 1.12e+00 | 0.0e+00 | 1.60e-01 | 8.8e-01 | -8.00e-02 | 9.2e-01 | 1.48e+00 | 0.0e+00 |
| 105 | Pfkfb3 | 1.40e+00 | 0.0e+00 | -2.50e-01 | 2.1e-01 | 4.60e-01 | 2.3e-01 | 9.30e-01 | 0.0e+00 | 5.30e-01 | 1.4e-01 | 1.52e+00 | 0.0e+00 |
| 104 | Per1 | 1.18e+00 | 0.0e+00 | 5.90e-01 | 1.0e-02 | 1.00e-02 | 9.8e-01 | 1.16e+00 | 0.0e+00 | 7.10e-01 | 0.0e+00 | 1.60e+00 | 0.0e+00 |
| 93 | Nfil3 | 1.02e+00 | 0.0e+00 | 1.00e-02 | 9.9e-01 | 9.90e-01 | 0.0e+00 | 6.00e-02 | 9.4e-01 | 1.18e+00 | 0.0e+00 | 1.66e+00 | 0.0e+00 |
| 97 | Nr4a1 | 1.80e-01 | 7.2e-01 | -2.70e-01 | 5.5e-01 | 5.00e-02 | 9.4e-01 | 1.00e-02 | 1.0e+00 | -4.00e-02 | 9.7e-01 | 1.72e+00 | 0.0e+00 |
| 8 | Bcl6 | 5.30e-01 | 1.0e-02 | 3.80e-01 | 1.6e-01 | 4.30e-01 | 1.7e-01 | 2.50e-01 | 7.6e-01 | 2.00e-01 | 6.8e-01 | 1.74e+00 | 0.0e+00 |
| 56 | Gadd45b | 6.30e-01 | 0.0e+00 | 1.80e-01 | 7.8e-01 | 9.00e-01 | 3.0e-02 | 1.58e+00 | 0.0e+00 | 3.90e-01 | 5.3e-01 | 1.75e+00 | 0.0e+00 |
| 24 | Cdkn1a | 2.14e+00 | 0.0e+00 | 1.85e+00 | 0.0e+00 | 9.20e-01 | 0.0e+00 | 3.34e+00 | 0.0e+00 | 2.30e+00 | 0.0e+00 | 2.54e+00 | 0.0e+00 |
| 34 | Cxcl3 | 1.20e-01 | 6.3e-01 | -5.30e-01 | 1.0e-01 | 9.30e-01 | 2.0e-02 | -1.80e-01 | NA | 4.00e-02 | NA | NA | NA |
| 69 | Il1a | 1.28e+00 | 0.0e+00 | -3.30e-01 | 4.9e-01 | 7.40e-01 | 2.4e-01 | -3.90e-01 | 3.3e-01 | -4.00e-02 | NA | NA | NA |
TNFa %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S23. Relative changes in the expression of genes involved in TNFa signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))CarbMet%>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>%kable(caption = "Supplementary Table 24. Relative changes in the expression of genes involved in carbohydrate metabolism after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(CarbMet$Adrenal_padj),F,ifelse(CarbMet$Adrenal_padj<.1,T,F)),color= ifelse(is.na(CarbMet$Adrenal_padj),"gray",ifelse(CarbMet$Adrenal_padj<.1,spec_color(CarbMet$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(CarbMet$HT_padj),F,ifelse(CarbMet$HT_padj<.1,T,F)),color= ifelse(is.na(CarbMet$HT_padj),"gray",ifelse(CarbMet$HT_padj<.1,spec_color(CarbMet$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(CarbMet$Liver_padj),F,ifelse(CarbMet$Liver_padj<.1,T,F)),color= ifelse(is.na(CarbMet$Liver_padj),"gray",ifelse(CarbMet$Liver_padj<.1,spec_color(CarbMet$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(CarbMet$Lung_padj),F,ifelse(CarbMet$Lung_padj<.1,T,F)),color= ifelse(is.na(CarbMet$Lung_padj),"gray",ifelse(CarbMet$Lung_padj <.1,spec_color(CarbMet$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(CarbMet$Adipose_padj),F,ifelse(CarbMet$Adipose_padj<.1,T,F)),color= ifelse(is.na(CarbMet$Adipose_padj),"gray",ifelse(CarbMet$Adipose_padj<.1, spec_color(CarbMet$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(CarbMet$Muscle_padj),F,ifelse(CarbMet$Muscle_padj<.1,T,F)),color= ifelse(is.na(CarbMet$Muscle_padj),"gray",ifelse(CarbMet$Muscle_padj<.1,spec_color(CarbMet$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 69 | Has2 | -2.60e-01 | 6.2e-01 | -2.0e-01 | 7.5e-01 | 2.80e-01 | 7.1e-01 | -5.40e-01 | NA | -7.70e-01 | 3.0e-02 | -2.66e+00 | 0.0e+00 |
| 39 | Dcn | -1.70e-01 | 7.6e-01 | -3.6e-01 | 4.4e-01 | 1.80e-01 | 7.4e-01 | 8.00e-02 | 9.5e-01 | 1.20e-01 | 8.0e-01 | -2.08e+00 | 0.0e+00 |
| 124 | Sdc1 | 4.00e-02 | 8.7e-01 | -4.4e-01 | 2.7e-01 | 1.05e+00 | 0.0e+00 | -9.00e-02 | 8.6e-01 | -3.10e-01 | 4.8e-01 | -1.93e+00 | 0.0e+00 |
| 135 | Slc2a1 | 3.60e-01 | 6.0e-02 | 6.3e-01 | 2.0e-02 | 2.90e-01 | 5.8e-01 | 3.50e-01 | 4.4e-01 | -1.00e-02 | 9.9e-01 | -1.88e+00 | 0.0e+00 |
| 10 | B3galt1 | -5.40e-01 | 9.0e-02 | 4.0e-02 | 9.5e-01 | -9.60e-01 | 0.0e+00 | -1.98e+00 | 0.0e+00 | -4.90e-01 | 3.1e-01 | -1.80e+00 | 0.0e+00 |
| 117 | Prelp | -7.00e-02 | 7.6e-01 | -3.0e-01 | 5.3e-01 | -4.00e-02 | 9.1e-01 | -2.10e-01 | 6.4e-01 | 0.00e+00 | 9.9e-01 | -1.80e+00 | 0.0e+00 |
| 20 | Bcan | 1.80e-01 | 6.6e-01 | 1.3e-01 | 8.2e-01 | 1.60e-01 | 7.3e-01 | -1.00e-01 | 9.3e-01 | 1.30e-01 | 8.8e-01 | -1.71e+00 | 1.0e-02 |
| 94 | Ogn | 2.80e-01 | 5.5e-01 | -1.7e-01 | 7.4e-01 | 4.50e-01 | 3.0e-01 | 4.50e-01 | 4.1e-01 | 4.00e-01 | 1.8e-01 | -1.60e+00 | 0.0e+00 |
| 150 | Vcan | -5.30e-01 | 2.0e-02 | 7.0e-02 | 9.1e-01 | 9.90e-01 | 0.0e+00 | -9.00e-01 | 0.0e+00 | 3.60e-01 | 1.6e-01 | -1.60e+00 | 0.0e+00 |
| 23 | Cd44 | -1.00e-01 | 5.0e-01 | 2.4e-01 | 5.1e-01 | 0.00e+00 | 1.0e+00 | -5.00e-02 | 9.8e-01 | -4.90e-01 | 2.0e-01 | -1.59e+00 | 0.0e+00 |
| 82 | Lum | -3.70e-01 | 2.0e-01 | -9.0e-02 | 9.0e-01 | 1.40e-01 | 5.7e-01 | 8.00e-02 | 9.6e-01 | 1.30e-01 | 8.4e-01 | -1.59e+00 | 0.0e+00 |
| 95 | Omd | 2.60e-01 | 3.3e-01 | -2.3e-01 | 6.9e-01 | 2.50e-01 | 5.1e-01 | 6.90e-01 | 0.0e+00 | 5.00e-01 | 2.9e-01 | -1.55e+00 | 0.0e+00 |
| 48 | Fmod | 1.00e-02 | 9.6e-01 | -3.0e-02 | 9.7e-01 | 8.00e-02 | 7.5e-01 | -3.00e-01 | 7.1e-01 | -1.00e-02 | 9.9e-01 | -1.54e+00 | 2.0e-02 |
| 149 | Ust | 3.10e-01 | 2.2e-01 | -3.6e-01 | 1.6e-01 | 4.50e-01 | 3.3e-01 | -2.90e-01 | 7.3e-01 | 7.90e-01 | 0.0e+00 | -1.52e+00 | 0.0e+00 |
| 11 | B3galt2 | -4.80e-01 | 2.8e-01 | 1.0e-02 | 9.9e-01 | 1.40e-01 | 8.7e-01 | 1.50e-01 | 8.9e-01 | 4.70e-01 | 4.3e-01 | -1.46e+00 | 0.0e+00 |
| 63 | Gpc3 | 2.40e-01 | 2.0e-02 | 4.0e-02 | 9.2e-01 | 1.60e-01 | 3.9e-01 | -8.00e-02 | 9.5e-01 | 2.00e-02 | 9.9e-01 | -1.44e+00 | 0.0e+00 |
| 21 | Bgn | 1.60e-01 | 3.4e-01 | -1.1e-01 | 8.7e-01 | 2.50e-01 | 2.0e-01 | 1.70e-01 | 6.6e-01 | -6.00e-02 | 9.3e-01 | -1.39e+00 | 0.0e+00 |
| 27 | Chst11 | -5.20e-01 | 2.0e-02 | -3.0e-02 | 9.5e-01 | 5.00e-02 | 9.3e-01 | -1.40e-01 | NA | 2.00e-02 | 9.7e-01 | -1.38e+00 | 1.0e-02 |
| 40 | Dse | -8.00e-02 | 6.0e-01 | -2.5e-01 | 5.6e-01 | 4.90e-01 | 0.0e+00 | 4.00e-02 | 9.2e-01 | 4.00e-02 | 9.3e-01 | -1.36e+00 | 0.0e+00 |
| 70 | Has3 | -1.27e+00 | 0.0e+00 | -4.5e-01 | 1.4e-01 | 4.80e-01 | 2.7e-01 | -3.30e-01 | 6.6e-01 | -1.61e+00 | 0.0e+00 | -1.33e+00 | 0.0e+00 |
| 26 | Chpf | 2.40e-01 | 1.9e-01 | 3.0e-02 | 9.4e-01 | -1.40e-01 | 1.8e-01 | 2.30e-01 | 4.3e-01 | 4.00e-02 | 9.5e-01 | -1.29e+00 | 0.0e+00 |
| 41 | Dsel | -1.90e-01 | 5.5e-01 | -1.2e-01 | 8.3e-01 | -1.40e-01 | 8.3e-01 | -3.90e-01 | 5.9e-01 | 2.00e-01 | 6.8e-01 | -1.29e+00 | 0.0e+00 |
| 34 | Cryl1 | -2.00e-02 | 9.6e-01 | 3.3e-01 | 3.2e-01 | -4.20e-01 | 2.9e-01 | -2.80e-01 | 3.9e-01 | 9.00e-02 | 8.6e-01 | -1.20e+00 | 1.0e-02 |
| 17 | B4galt5 | 4.40e-01 | 0.0e+00 | -1.7e-01 | 2.6e-01 | -8.30e-01 | 0.0e+00 | -3.80e-01 | 5.0e-02 | -5.00e-01 | 2.0e-01 | -1.10e+00 | 0.0e+00 |
| 55 | Gbe1 | -6.00e-02 | 7.6e-01 | -3.0e-02 | 9.4e-01 | -1.30e-01 | 6.6e-01 | -1.00e-02 | 9.9e-01 | 2.30e-01 | 6.5e-01 | -1.07e+00 | 0.0e+00 |
| 35 | Csgalnact1 | -5.10e-01 | 0.0e+00 | -1.2e-01 | 7.6e-01 | -4.90e-01 | 8.0e-02 | -1.90e-01 | 6.8e-01 | -9.00e-02 | 7.8e-01 | -1.07e+00 | 0.0e+00 |
| 32 | Chsy1 | -2.20e-01 | 1.6e-01 | 3.0e-02 | 9.5e-01 | 1.38e+00 | 0.0e+00 | 1.60e-01 | 7.6e-01 | 2.00e-01 | 3.2e-01 | -1.05e+00 | 0.0e+00 |
| 139 | Slc9a1 | 1.00e-02 | 9.5e-01 | 4.0e-02 | 9.3e-01 | -3.50e-01 | 1.0e-02 | -1.90e-01 | 4.4e-01 | -3.70e-01 | 4.0e-02 | -1.03e+00 | 0.0e+00 |
| 125 | Sdc2 | -1.50e-01 | 3.8e-01 | -5.0e-02 | 9.3e-01 | -1.90e-01 | 5.3e-01 | -4.90e-01 | 0.0e+00 | -1.10e-01 | 8.1e-01 | -1.03e+00 | 0.0e+00 |
| 31 | Chst7 | -7.20e-01 | 0.0e+00 | -2.7e-01 | 4.2e-01 | -4.10e-01 | 4.4e-01 | -6.90e-01 | 1.6e-01 | -5.60e-01 | 1.0e-02 | -1.03e+00 | 0.0e+00 |
| 120 | Pygl | -1.80e-01 | 2.6e-01 | -1.0e-01 | 8.2e-01 | 3.00e-01 | 5.7e-01 | -1.70e-01 | 2.7e-01 | 6.00e-02 | 9.1e-01 | -9.90e-01 | 0.0e+00 |
| 52 | G6pd | -1.00e-02 | 9.6e-01 | 7.0e-02 | 7.6e-01 | -2.00e-02 | 8.7e-01 | 1.50e-01 | 7.2e-01 | 1.80e-01 | 6.3e-01 | -9.80e-01 | 0.0e+00 |
| 119 | Prps2 | 5.00e-02 | 8.0e-01 | 0.0e+00 | 9.9e-01 | 1.10e-01 | 6.7e-01 | -3.80e-01 | 2.0e-02 | -2.30e-01 | 4.9e-01 | -9.80e-01 | 0.0e+00 |
| 15 | B3gnt7 | -1.90e-01 | 4.8e-01 | -2.0e-01 | 6.1e-01 | -1.80e-01 | 6.5e-01 | -6.20e-01 | 2.7e-01 | -5.30e-01 | 3.3e-01 | -9.70e-01 | 7.0e-02 |
| 68 | Has1 | 1.63e+00 | 0.0e+00 | -1.1e-01 | 8.8e-01 | 1.17e+00 | 0.0e+00 | 1.60e-01 | NA | 1.60e-01 | 8.4e-01 | -9.60e-01 | 1.1e-01 |
| 78 | Hyal1 | 4.90e-01 | 4.0e-02 | -1.1e-01 | 7.2e-01 | 2.90e-01 | 3.0e-01 | 1.00e-02 | 9.9e-01 | 3.40e-01 | 1.8e-01 | -9.30e-01 | 0.0e+00 |
| 42 | Eno2 | -2.30e-01 | 3.4e-01 | 1.5e-01 | 6.5e-01 | 1.30e-01 | 6.6e-01 | -2.20e-01 | 7.5e-01 | -1.90e-01 | 7.5e-01 | -9.20e-01 | 0.0e+00 |
| 14 | B3gnt2 | 3.10e-01 | 0.0e+00 | 1.4e-01 | 6.0e-01 | 2.50e-01 | 3.8e-01 | -3.10e-01 | 3.3e-01 | -6.00e-02 | 9.0e-01 | -8.90e-01 | 0.0e+00 |
| 77 | Hs6st2 | -1.90e-01 | 6.4e-01 | -7.0e-02 | 9.0e-01 | 1.10e-01 | NA | -3.50e-01 | NA | 8.00e-02 | 9.2e-01 | -8.70e-01 | 1.0e-02 |
| 71 | Hk1 | 1.50e-01 | 1.4e-01 | 8.0e-02 | 7.6e-01 | 1.50e-01 | 5.3e-01 | -1.00e-01 | 9.0e-01 | -3.00e-02 | 9.4e-01 | -8.70e-01 | 0.0e+00 |
| 37 | Cspg4 | 1.80e-01 | 1.8e-01 | -1.6e-01 | 6.9e-01 | -8.00e-02 | 7.7e-01 | 3.00e-02 | 9.9e-01 | -4.10e-01 | 1.8e-01 | -8.60e-01 | 0.0e+00 |
| 75 | Hs3st3b1 | -4.10e-01 | 2.0e-02 | -4.2e-01 | 3.2e-01 | -1.10e-01 | 7.5e-01 | 5.50e-01 | 0.0e+00 | -9.80e-01 | 0.0e+00 | -8.50e-01 | 5.0e-02 |
| 24 | Cemip | -1.35e+00 | 0.0e+00 | -4.9e-01 | 1.2e-01 | -3.80e-01 | 5.9e-01 | 1.32e+00 | 0.0e+00 | -1.00e-02 | NA | -8.50e-01 | 2.2e-01 |
| 84 | Man2b2 | -3.00e-02 | 9.4e-01 | 1.2e-01 | 8.3e-01 | -1.50e-01 | 7.3e-01 | 0.00e+00 | 1.0e+00 | -3.00e-02 | 9.7e-01 | -8.40e-01 | 3.0e-02 |
| 60 | Gnpda2 | 3.10e-01 | 5.0e-02 | -7.0e-02 | 9.1e-01 | 2.20e-01 | 6.9e-01 | 2.50e-01 | 7.1e-01 | 2.50e-01 | 6.4e-01 | -8.40e-01 | 0.0e+00 |
| 74 | Hpse | 2.20e-01 | 1.8e-01 | 3.0e-02 | 9.7e-01 | -8.00e-02 | 9.1e-01 | -2.60e-01 | 7.0e-01 | -3.00e-02 | 9.7e-01 | -8.10e-01 | 3.0e-02 |
| 142 | St3gal6 | -4.80e-01 | 0.0e+00 | -3.8e-01 | 9.0e-02 | -1.00e-01 | 7.7e-01 | -7.80e-01 | 0.0e+00 | -6.40e-01 | 3.0e-02 | -7.80e-01 | 0.0e+00 |
| 144 | Tkt | -9.00e-02 | 8.3e-01 | 4.0e-02 | 9.4e-01 | 1.00e-01 | 7.7e-01 | 1.30e-01 | 6.8e-01 | 3.00e-01 | 4.6e-01 | -7.80e-01 | 0.0e+00 |
| 33 | Chsy3 | 0.00e+00 | 1.0e+00 | -4.3e-01 | 2.0e-01 | 2.00e-02 | 9.9e-01 | -6.90e-01 | 9.0e-02 | 1.70e-01 | 8.3e-01 | -7.70e-01 | 2.8e-01 |
| 129 | Shpk | 1.10e-01 | 5.4e-01 | -1.0e-02 | 9.9e-01 | -6.30e-01 | 0.0e+00 | -2.60e-01 | 5.0e-02 | -9.00e-02 | 7.9e-01 | -7.60e-01 | 2.0e-02 |
| 140 | Sord | -2.70e-01 | 1.2e-01 | -4.0e-02 | 9.3e-01 | -7.20e-01 | 0.0e+00 | -3.40e-01 | 6.0e-02 | 1.00e-02 | 9.9e-01 | -7.40e-01 | 0.0e+00 |
| 97 | Pck1 | -6.50e-01 | 1.0e-02 | 0.0e+00 | 1.0e+00 | 1.90e-01 | 7.9e-01 | 9.00e-02 | 8.4e-01 | -2.00e-02 | 9.9e-01 | -7.40e-01 | 2.4e-01 |
| 16 | B4galt1 | 3.30e-01 | 0.0e+00 | -4.4e-01 | 1.2e-01 | -3.90e-01 | 9.0e-02 | -3.30e-01 | 8.0e-02 | -2.40e-01 | 4.9e-01 | -7.20e-01 | 0.0e+00 |
| 76 | Hs3st5 | -7.20e-01 | 7.0e-02 | -6.0e-02 | 9.3e-01 | 3.70e-01 | 6.0e-01 | -2.00e-02 | NA | -3.00e-01 | NA | -7.20e-01 | 6.0e-02 |
| 36 | Csgalnact2 | 2.80e-01 | 9.0e-02 | -7.0e-02 | 8.8e-01 | 3.00e-01 | 7.0e-02 | 2.00e-01 | 5.9e-01 | 3.00e-01 | 2.8e-01 | -7.10e-01 | 0.0e+00 |
| 86 | Mdh1 | -2.00e-02 | 9.7e-01 | 8.0e-02 | 9.1e-01 | 4.00e-02 | 9.5e-01 | 5.20e-01 | 1.0e-02 | 2.50e-01 | 5.5e-01 | -7.10e-01 | 0.0e+00 |
| 25 | Chp1 | 2.30e-01 | 2.0e-02 | -1.0e-02 | 9.8e-01 | 4.00e-01 | 7.0e-02 | 0.00e+00 | 9.9e-01 | 2.00e-02 | 9.7e-01 | -7.00e-01 | 0.0e+00 |
| 9 | Arsb | 1.20e-01 | 2.1e-01 | 2.0e-02 | 9.4e-01 | 8.50e-01 | 0.0e+00 | 3.40e-01 | 2.0e-02 | -2.00e-01 | 3.8e-01 | -6.80e-01 | 0.0e+00 |
| 45 | Ext1 | -2.00e-02 | 9.1e-01 | -2.0e-01 | 4.9e-01 | 1.11e+00 | 0.0e+00 | 7.50e-01 | 0.0e+00 | -3.00e-01 | 9.0e-02 | -6.60e-01 | 0.0e+00 |
| 137 | Slc37a2 | -1.70e-01 | 5.4e-01 | -7.0e-02 | 9.2e-01 | 3.30e-01 | 3.7e-01 | -2.30e-01 | 6.9e-01 | -3.60e-01 | 3.9e-01 | -6.60e-01 | 0.0e+00 |
| 89 | Nup210 | -5.30e-01 | 0.0e+00 | -9.0e-02 | 8.7e-01 | 1.00e-02 | 9.9e-01 | -1.30e-01 | 8.4e-01 | -2.40e-01 | 5.5e-01 | -6.40e-01 | 1.0e-02 |
| 105 | Pgm2 | -2.90e-01 | 0.0e+00 | 7.0e-02 | 8.5e-01 | 5.90e-01 | 0.0e+00 | -8.00e-02 | 8.8e-01 | 1.10e-01 | 7.7e-01 | -6.40e-01 | 1.0e-02 |
| 29 | Chst15 | 1.10e-01 | 6.7e-01 | -3.2e-01 | 5.0e-01 | 4.00e-01 | 7.0e-02 | -5.00e-02 | 9.6e-01 | -5.20e-01 | 1.2e-01 | -6.30e-01 | 1.0e-02 |
| 57 | Glb1l | 0.00e+00 | 1.0e+00 | -1.3e-01 | 7.5e-01 | -1.80e-01 | 6.1e-01 | 2.00e-02 | 9.8e-01 | 2.00e-02 | 9.7e-01 | -6.20e-01 | 3.0e-02 |
| 12 | B3galt6 | -1.40e-01 | 5.5e-01 | 0.0e+00 | 1.0e+00 | 9.00e-02 | 8.0e-01 | 1.30e-01 | 8.0e-01 | -4.80e-01 | 6.0e-02 | -6.20e-01 | 3.0e-02 |
| 38 | Cspg5 | -1.50e-01 | 7.6e-01 | 9.0e-02 | 8.2e-01 | 3.40e-01 | 3.3e-01 | -1.10e-01 | 9.2e-01 | -7.90e-01 | 0.0e+00 | -6.10e-01 | 1.5e-01 |
| 114 | Ppp2ca | 1.30e-01 | 7.3e-01 | -6.0e-02 | 9.2e-01 | 2.90e-01 | 5.9e-01 | 1.07e+00 | 0.0e+00 | 4.80e-01 | 2.5e-01 | -5.40e-01 | 1.0e-01 |
| 51 | G6pc | -4.90e-01 | 1.9e-01 | -6.0e-02 | 8.8e-01 | -6.60e-01 | 1.7e-01 | 1.01e+00 | 0.0e+00 | 7.00e-02 | 9.4e-01 | -5.30e-01 | NA |
| 4 | Adpgk | -8.00e-02 | 6.1e-01 | -3.6e-01 | 0.0e+00 | -9.00e-01 | 0.0e+00 | 1.20e-01 | 6.9e-01 | 1.10e-01 | 5.8e-01 | -5.00e-01 | 3.0e-02 |
| 134 | Slc26a2 | -3.50e-01 | 3.2e-01 | -7.2e-01 | 2.0e-02 | -2.40e-01 | 6.0e-01 | -3.20e-01 | 6.7e-01 | 5.00e-02 | 9.4e-01 | -4.90e-01 | 1.9e-01 |
| 99 | Pfkfb2 | 4.00e-02 | 8.9e-01 | -6.0e-02 | 8.8e-01 | -9.00e-02 | 8.3e-01 | 6.80e-01 | 1.0e-02 | -2.70e-01 | 4.2e-01 | -4.90e-01 | 4.0e-02 |
| 115 | Ppp2cb | 9.00e-02 | 5.4e-01 | -2.0e-02 | 9.8e-01 | 6.00e-01 | 6.0e-02 | -1.40e-01 | 8.1e-01 | 3.10e-01 | 3.8e-01 | -4.70e-01 | 9.0e-02 |
| 28 | Chst14 | -1.50e-01 | 3.4e-01 | -1.6e-01 | 7.7e-01 | 1.80e-01 | 6.2e-01 | -6.10e-01 | 3.0e-02 | -5.10e-01 | 1.0e-02 | -3.80e-01 | 2.8e-01 |
| 128 | Sgsh | 7.00e-02 | 8.0e-01 | 2.2e-01 | 6.2e-01 | -8.30e-01 | 1.0e-02 | 2.00e-01 | 6.4e-01 | 1.60e-01 | 7.7e-01 | -3.70e-01 | 3.7e-01 |
| 64 | Gpc4 | 3.00e-01 | 0.0e+00 | -2.0e-02 | 9.8e-01 | 1.05e+00 | 0.0e+00 | -3.30e-01 | 0.0e+00 | 5.00e-02 | 9.0e-01 | -2.90e-01 | 1.0e-01 |
| 87 | Ndst1 | 2.60e-01 | 3.2e-01 | -1.2e-01 | 7.5e-01 | 6.30e-01 | 4.0e-02 | -3.90e-01 | 4.8e-01 | -1.30e-01 | 7.3e-01 | -2.60e-01 | 3.9e-01 |
| 109 | Phka2 | 4.00e-02 | 9.4e-01 | -1.0e-01 | 9.0e-01 | 2.80e-01 | 7.2e-01 | -2.50e-01 | 7.7e-01 | 2.03e+00 | 0.0e+00 | -2.60e-01 | 7.6e-01 |
| 46 | Ext2 | -2.00e-02 | 8.8e-01 | -3.0e-02 | 9.2e-01 | -7.10e-01 | 0.0e+00 | -3.20e-01 | 2.0e-02 | -1.70e-01 | 5.8e-01 | -2.10e-01 | 1.4e-01 |
| 3 | Acan | -5.90e-01 | 8.0e-02 | -2.3e-01 | 4.1e-01 | 3.76e+00 | 0.0e+00 | -3.60e-01 | NA | 9.00e-02 | NA | -2.00e-01 | NA |
| 44 | Eno4 | -1.00e-02 | 9.7e-01 | 2.0e-01 | 5.3e-01 | 1.02e+00 | 0.0e+00 | 1.70e-01 | 8.7e-01 | -8.00e-02 | 8.9e-01 | -1.40e-01 | 8.0e-01 |
| 132 | Slc25a13 | 4.30e-01 | 2.0e-02 | 1.0e+00 | 0.0e+00 | -2.80e-01 | 3.9e-01 | -4.00e-02 | 9.6e-01 | 1.10e+00 | 0.0e+00 | -1.10e-01 | 8.2e-01 |
| 49 | Fut10 | -3.20e-01 | 1.2e-01 | -1.7e-01 | 5.6e-01 | -1.04e+00 | 0.0e+00 | -2.10e-01 | 7.2e-01 | -4.70e-01 | 4.0e-02 | -1.00e-01 | 7.1e-01 |
| 66 | Gyg1 | 2.00e-02 | 9.2e-01 | -3.0e-02 | 9.4e-01 | -9.30e-01 | 0.0e+00 | -4.80e-01 | 1.0e-02 | -1.50e-01 | 6.6e-01 | -8.00e-02 | 7.4e-01 |
| 85 | Manba | 4.00e-02 | 8.2e-01 | -2.2e-01 | 1.7e-01 | -6.10e-01 | 0.0e+00 | -1.70e-01 | 5.1e-01 | 0.00e+00 | 9.9e-01 | -5.00e-02 | 8.7e-01 |
| 53 | Gale | 7.00e-02 | 8.8e-01 | 1.5e-01 | 8.2e-01 | -5.00e-02 | 9.4e-01 | 7.60e-01 | 4.0e-02 | 4.00e-02 | 9.6e-01 | 0.00e+00 | 1.0e+00 |
| 130 | Slc25a10 | 6.40e-01 | 0.0e+00 | 1.3e-01 | 7.3e-01 | -4.50e-01 | 8.0e-02 | 3.40e-01 | 3.2e-01 | 2.00e-02 | 9.7e-01 | 0.00e+00 | 1.0e+00 |
| 83 | Lyve1 | 1.45e+00 | 0.0e+00 | 1.8e-01 | 7.7e-01 | -1.00e-02 | 9.9e-01 | 1.40e-01 | 7.0e-01 | 9.00e-01 | 0.0e+00 | 0.00e+00 | 9.9e-01 |
| 72 | Hk2 | 1.01e+00 | 0.0e+00 | -2.7e-01 | 2.8e-01 | 7.10e-01 | 0.0e+00 | -6.00e-01 | 1.6e-01 | 6.80e-01 | 2.0e-02 | 1.00e-02 | 9.7e-01 |
| 92 | Nup98 | 1.20e-01 | 4.5e-01 | -1.6e-01 | 6.2e-01 | 1.40e-01 | 6.9e-01 | -7.20e-01 | 0.0e+00 | 1.00e-01 | 7.9e-01 | 2.00e-02 | 9.5e-01 |
| 62 | Gpc2 | -1.00e-01 | 7.6e-01 | -1.9e-01 | 7.2e-01 | -5.50e-01 | 3.0e-02 | 2.30e-01 | 8.0e-01 | -6.60e-01 | 5.0e-02 | 2.00e-02 | 9.6e-01 |
| 122 | Rpia | -4.50e-01 | 0.0e+00 | -1.3e-01 | 7.6e-01 | -6.00e-01 | 2.0e-02 | -3.20e-01 | 1.1e-01 | -3.90e-01 | 2.0e-02 | 2.00e-02 | 9.2e-01 |
| 116 | Ppp2r1b | 8.00e-02 | 5.0e-01 | 5.0e-02 | 9.0e-01 | 7.60e-01 | 0.0e+00 | -1.30e-01 | 7.9e-01 | -5.30e-01 | 1.0e-02 | 6.00e-02 | 8.4e-01 |
| 123 | Sat1 | 9.60e-01 | 0.0e+00 | 2.4e-01 | 5.0e-01 | 5.60e-01 | 4.0e-02 | 1.50e-01 | 7.3e-01 | 6.50e-01 | 5.0e-02 | 1.10e-01 | 7.0e-01 |
| 79 | Hyal2 | 1.03e+00 | 0.0e+00 | 2.8e-01 | 4.5e-01 | -2.90e-01 | 3.3e-01 | 2.90e-01 | 3.8e-01 | 2.80e-01 | 4.4e-01 | 1.30e-01 | 6.1e-01 |
| 148 | Ugp2 | 0.00e+00 | 9.8e-01 | -1.7e-01 | 3.5e-01 | 2.90e-01 | 5.0e-02 | -7.90e-01 | 0.0e+00 | 3.00e-02 | 9.6e-01 | 1.40e-01 | 6.9e-01 |
| 143 | St6galnac6 | -8.00e-02 | 8.1e-01 | 6.0e-02 | 9.0e-01 | -1.00e-02 | 9.9e-01 | 5.90e-01 | 1.0e-02 | -7.00e-02 | 7.9e-01 | 1.80e-01 | 2.8e-01 |
| 59 | Gnpda1 | -2.00e-02 | 9.2e-01 | -1.1e-01 | 7.2e-01 | -9.10e-01 | 0.0e+00 | 9.00e-02 | 8.6e-01 | -4.40e-01 | 5.0e-02 | 2.00e-01 | 2.0e-01 |
| 133 | Slc26a1 | -6.80e-01 | 8.0e-02 | -1.8e-01 | 7.3e-01 | -8.30e-01 | 5.0e-02 | 2.80e-01 | 3.3e-01 | -6.00e-02 | 9.3e-01 | 2.20e-01 | 6.6e-01 |
| 6 | Akr1b1 | -9.00e-02 | 6.5e-01 | 1.2e-01 | 7.9e-01 | 1.99e+00 | 0.0e+00 | -2.50e-01 | 5.7e-01 | 3.10e-01 | 2.9e-01 | 2.40e-01 | 3.2e-01 |
| 118 | Prkacb | 1.10e-01 | 6.6e-01 | -5.0e-02 | 9.2e-01 | 9.30e-01 | 0.0e+00 | 1.90e-01 | 7.9e-01 | 2.30e-01 | 5.8e-01 | 3.00e-01 | 7.0e-02 |
| 18 | B4galt7 | 1.70e-01 | 4.4e-01 | 1.1e-01 | 7.9e-01 | -7.30e-01 | 0.0e+00 | 2.00e-01 | 5.8e-01 | 8.00e-02 | 8.8e-01 | 3.10e-01 | 1.3e-01 |
| 73 | Hmmr | -8.00e-02 | 8.6e-01 | -1.6e-01 | 7.7e-01 | -7.40e-01 | 7.0e-02 | 5.70e-01 | 2.3e-01 | 9.00e-02 | 9.0e-01 | 3.20e-01 | 3.1e-01 |
| 67 | Gys1 | 1.20e-01 | 5.1e-01 | -2.0e-02 | 9.6e-01 | -4.00e-01 | 1.0e-01 | 7.60e-01 | 0.0e+00 | 7.00e-02 | 8.0e-01 | 3.70e-01 | 2.0e-02 |
| 19 | B4gat1 | 5.00e-02 | 8.4e-01 | 3.2e-01 | 3.0e-02 | -7.80e-01 | 0.0e+00 | 1.90e-01 | 6.9e-01 | -2.30e-01 | 5.2e-01 | 4.60e-01 | 4.0e-02 |
| 61 | Got1 | 1.40e-01 | 6.3e-01 | 8.0e-02 | 7.6e-01 | 5.80e-01 | 0.0e+00 | 2.42e+00 | 0.0e+00 | -5.50e-01 | 1.4e-01 | 4.90e-01 | 3.0e-02 |
| 88 | Nhlrc1 | -3.30e-01 | 2.9e-01 | -3.0e-02 | 9.5e-01 | 8.00e-02 | 8.8e-01 | 6.40e-01 | 5.0e-02 | -9.40e-01 | 1.0e-02 | 5.00e-01 | 6.0e-02 |
| 2 | Abcc5 | -9.00e-02 | 7.2e-01 | -9.0e-02 | 8.6e-01 | -5.80e-01 | 7.0e-02 | -3.10e-01 | 4.2e-01 | -4.00e-01 | 2.0e-02 | 5.90e-01 | 0.0e+00 |
| 146 | Ubb | 4.40e-01 | 0.0e+00 | 2.6e-01 | 2.5e-01 | -7.80e-01 | 0.0e+00 | 1.00e-01 | 8.6e-01 | 1.10e-01 | 7.6e-01 | 6.00e-01 | 0.0e+00 |
| 93 | Nupl2 | 3.20e-01 | 3.0e-02 | 4.7e-01 | 1.0e-02 | 1.60e-01 | 7.3e-01 | 7.00e-01 | 0.0e+00 | 4.30e-01 | 8.0e-02 | 6.10e-01 | 0.0e+00 |
| 58 | Glyctk | -3.50e-01 | 2.8e-01 | 7.0e-02 | 9.2e-01 | -7.40e-01 | 4.0e-02 | 2.70e-01 | 1.9e-01 | -5.70e-01 | 1.1e-01 | 6.30e-01 | 2.0e-02 |
| 56 | Gck | -2.30e-01 | 5.8e-01 | 0.0e+00 | 1.0e+00 | -4.00e-01 | 5.7e-01 | -1.30e+00 | 0.0e+00 | 1.00e-01 | NA | 6.30e-01 | NA |
| 90 | Nup62 | 1.50e-01 | 5.3e-01 | 1.0e-02 | 9.9e-01 | 8.70e-01 | 0.0e+00 | 3.10e-01 | 2.4e-01 | 1.00e-01 | 7.3e-01 | 6.40e-01 | 0.0e+00 |
| 127 | Sec13 | 1.70e-01 | 4.4e-01 | 1.2e-01 | 6.7e-01 | 1.30e-01 | 7.4e-01 | 1.80e-01 | 7.0e-01 | 4.20e-01 | 1.0e-02 | 6.60e-01 | 0.0e+00 |
| 138 | Slc37a4 | 1.30e-01 | 4.8e-01 | 1.7e-01 | 6.9e-01 | -5.80e-01 | 0.0e+00 | 4.50e-01 | 3.0e-02 | -3.30e-01 | 3.4e-01 | 7.00e-01 | 0.0e+00 |
| 1 | Aaas | 1.30e-01 | 6.0e-01 | 7.0e-02 | 9.0e-01 | -5.80e-01 | 4.0e-02 | 7.00e-02 | 9.2e-01 | -2.50e-01 | 4.0e-01 | 7.00e-01 | 0.0e+00 |
| 98 | Pfkfb1 | 5.70e-01 | 4.0e-02 | 0.0e+00 | 1.0e+00 | -7.00e-02 | 9.3e-01 | 6.60e-01 | 2.0e-02 | -1.10e-01 | 6.6e-01 | 7.10e-01 | 0.0e+00 |
| 13 | B3gat3 | 1.20e-01 | 6.6e-01 | 1.4e-01 | 6.5e-01 | 1.40e-01 | 7.3e-01 | 1.90e-01 | 5.6e-01 | 1.00e-01 | 8.4e-01 | 7.20e-01 | 0.0e+00 |
| 112 | Pkm | 1.80e-01 | 3.4e-01 | 9.0e-02 | 8.2e-01 | 7.00e-02 | 7.9e-01 | -2.70e-01 | 5.9e-01 | -6.00e-02 | 9.1e-01 | 7.70e-01 | 0.0e+00 |
| 106 | Pgm2l1 | -6.60e-01 | 0.0e+00 | -2.1e-01 | 6.0e-01 | -4.90e-01 | 9.0e-02 | -5.00e-01 | 1.5e-01 | -6.20e-01 | 1.0e-02 | 8.10e-01 | 0.0e+00 |
| 126 | Sdc4 | 6.80e-01 | 0.0e+00 | 2.7e-01 | 4.9e-01 | 4.00e-01 | 2.4e-01 | 1.09e+00 | 0.0e+00 | 7.60e-01 | 7.0e-02 | 8.10e-01 | 0.0e+00 |
| 136 | Slc35b2 | 1.00e-01 | 7.5e-01 | 2.0e-02 | 9.8e-01 | 3.80e-01 | 8.0e-02 | -1.80e-01 | 4.2e-01 | -2.50e-01 | 4.6e-01 | 8.30e-01 | 0.0e+00 |
| 103 | Pgk1 | 1.70e-01 | 5.2e-01 | 4.0e-02 | 9.4e-01 | 3.40e-01 | 5.0e-02 | 2.30e-01 | 5.4e-01 | 1.30e-01 | 7.6e-01 | 8.40e-01 | 0.0e+00 |
| 5 | Agl | -2.60e-01 | 5.0e-02 | -1.8e-01 | 4.7e-01 | -6.30e-01 | 0.0e+00 | -6.80e-01 | 0.0e+00 | -4.50e-01 | 3.5e-01 | 8.60e-01 | 0.0e+00 |
| 141 | St3gal1 | 3.00e-02 | 8.5e-01 | -2.1e-01 | 4.2e-01 | -3.00e-02 | 9.4e-01 | 5.00e-01 | 1.0e-02 | -3.40e-01 | 3.3e-01 | 8.80e-01 | 0.0e+00 |
| 131 | Slc25a12 | 2.20e-01 | 1.2e-01 | 3.0e-02 | 9.6e-01 | -6.20e-01 | 0.0e+00 | 4.00e-01 | 9.0e-02 | -4.90e-01 | 2.6e-01 | 8.80e-01 | 0.0e+00 |
| 8 | Aldoa | 4.00e-02 | 8.6e-01 | 2.1e-01 | 2.6e-01 | 1.40e-01 | 6.6e-01 | 6.30e-01 | 0.0e+00 | 1.70e-01 | 6.8e-01 | 9.10e-01 | 0.0e+00 |
| 80 | Hyal3 | 9.50e-01 | 0.0e+00 | 6.0e-02 | 9.0e-01 | 1.33e+00 | 0.0e+00 | 1.30e-01 | 9.0e-01 | 4.50e-01 | 1.2e-01 | 9.10e-01 | 0.0e+00 |
| 96 | Pc | -2.10e-01 | 6.3e-01 | 6.0e-02 | 8.7e-01 | -8.00e-02 | 8.0e-01 | -1.10e-01 | 6.9e-01 | 9.00e-02 | 7.8e-01 | 9.30e-01 | 0.0e+00 |
| 7 | Aldh1a1 | -1.90e-01 | 2.8e-01 | 1.7e-01 | 7.8e-01 | 8.30e-01 | 1.4e-01 | -4.00e-02 | 9.7e-01 | -5.20e-01 | 3.6e-01 | 9.30e-01 | 0.0e+00 |
| 104 | Pgm1 | -3.00e-02 | 9.4e-01 | 1.0e-01 | 7.9e-01 | -3.80e-01 | 5.0e-02 | 5.00e-02 | 8.8e-01 | -3.60e-01 | 3.9e-01 | 9.40e-01 | 0.0e+00 |
| 107 | Pgp | 4.20e-01 | 0.0e+00 | 2.0e-02 | 9.7e-01 | -1.60e-01 | 4.5e-01 | 9.00e-02 | 8.4e-01 | -1.20e-01 | 7.6e-01 | 9.50e-01 | 0.0e+00 |
| 151 | Xylt1 | 2.10e-01 | 6.4e-01 | -7.0e-02 | 9.3e-01 | -1.20e-01 | 8.7e-01 | -9.00e-02 | NA | 1.48e+00 | 0.0e+00 | 9.50e-01 | 0.0e+00 |
| 108 | Phka1 | -3.80e-01 | 1.0e-02 | -9.0e-02 | 8.4e-01 | -6.90e-01 | 2.0e-02 | -4.00e-02 | 9.6e-01 | -5.20e-01 | 2.8e-01 | 9.80e-01 | 0.0e+00 |
| 91 | Nup93 | 4.50e-01 | 0.0e+00 | 9.0e-02 | 7.0e-01 | 3.40e-01 | 5.0e-02 | 2.50e-01 | 2.2e-01 | 1.50e-01 | 5.2e-01 | 9.80e-01 | 0.0e+00 |
| 145 | Tpi1 | -2.00e-02 | 9.5e-01 | 1.7e-01 | 7.0e-01 | 3.30e-01 | 6.0e-02 | 0.00e+00 | 1.0e+00 | -1.20e-01 | 8.0e-01 | 1.00e+00 | 0.0e+00 |
| 81 | Khk | 1.40e-01 | 7.7e-01 | 3.8e-01 | 3.4e-01 | -4.40e-01 | 4.1e-01 | -1.40e-01 | 8.3e-01 | 7.00e-02 | 9.3e-01 | 1.04e+00 | 7.0e-02 |
| 47 | Fbp2 | 2.50e-01 | 3.7e-01 | 2.4e-01 | NA | 4.90e-01 | 4.5e-01 | -1.00e-02 | 1.0e+00 | -6.80e-01 | 1.0e-01 | 1.05e+00 | 0.0e+00 |
| 43 | Eno3 | -7.80e-01 | 0.0e+00 | 6.0e-02 | 9.3e-01 | -8.80e-01 | 0.0e+00 | -2.50e-01 | 6.8e-01 | -6.10e-01 | 1.6e-01 | 1.06e+00 | 0.0e+00 |
| 121 | Pygm | -1.50e-01 | 7.1e-01 | 2.7e-01 | 1.0e-01 | 5.00e-01 | 7.0e-02 | -3.00e-01 | 7.2e-01 | -5.50e-01 | 2.0e-01 | 1.07e+00 | 0.0e+00 |
| 54 | Gapdh | -3.00e-01 | 5.4e-01 | -4.0e-02 | 9.6e-01 | -1.30e-01 | 8.6e-01 | 6.90e-01 | 1.7e-01 | 1.30e-01 | NA | 1.08e+00 | 1.0e-02 |
| 110 | Phkb | -5.00e-01 | 2.0e-02 | -1.3e-01 | 8.3e-01 | -3.70e-01 | 1.0e-02 | -2.00e-01 | 7.1e-01 | -8.00e-02 | 8.8e-01 | 1.16e+00 | 0.0e+00 |
| 65 | Gpi | 2.20e-01 | 2.7e-01 | 1.4e-01 | 6.8e-01 | 4.00e-02 | 9.3e-01 | -5.00e-02 | 9.4e-01 | 1.40e-01 | 6.0e-01 | 1.16e+00 | 0.0e+00 |
| 111 | Phkg1 | -8.80e-01 | 3.0e-02 | 8.0e-02 | 8.8e-01 | -3.00e-02 | 9.7e-01 | -3.60e-01 | NA | -9.90e-01 | 2.0e-02 | 1.23e+00 | 0.0e+00 |
| 50 | Fut7 | -6.00e-02 | 9.3e-01 | 4.5e-01 | 2.8e-01 | 1.13e+00 | 1.0e-02 | -1.80e-01 | NA | -5.00e-02 | 9.6e-01 | 1.29e+00 | 5.0e-02 |
| 30 | Chst3 | 8.40e-01 | 0.0e+00 | 6.1e-01 | 0.0e+00 | -3.90e-01 | 7.0e-02 | 8.10e-01 | 4.0e-02 | 2.10e-01 | 6.0e-01 | 1.31e+00 | 0.0e+00 |
| 22 | Bpgm | 1.80e-01 | 3.5e-01 | 2.8e-01 | 1.6e-01 | 1.00e-02 | 9.8e-01 | 7.00e-02 | 9.2e-01 | -6.00e-02 | 9.1e-01 | 1.32e+00 | 0.0e+00 |
| 147 | Ubc | 9.30e-01 | 0.0e+00 | 1.2e-01 | 7.0e-01 | -2.90e-01 | 3.1e-01 | -7.50e-01 | 0.0e+00 | 3.10e-01 | 2.4e-01 | 1.48e+00 | 0.0e+00 |
| 100 | Pfkfb3 | 1.40e+00 | 0.0e+00 | -2.5e-01 | 2.1e-01 | 4.60e-01 | 2.3e-01 | 9.30e-01 | 0.0e+00 | 5.30e-01 | 1.4e-01 | 1.52e+00 | 0.0e+00 |
| 102 | Pgam2 | 8.00e-02 | 8.7e-01 | 2.4e-01 | 6.0e-01 | -4.00e-01 | 3.2e-01 | 4.90e-01 | 4.3e-01 | -6.50e-01 | 1.5e-01 | 1.85e+00 | 0.0e+00 |
| 101 | Pfkfb4 | 2.00e-01 | 2.8e-01 | 2.9e-01 | 1.1e-01 | 2.70e-01 | 2.7e-01 | 7.00e-02 | 9.5e-01 | 2.00e-01 | 6.9e-01 | 2.81e+00 | 0.0e+00 |
| 113 | Ppp1r3c | -6.60e-01 | 0.0e+00 | -2.0e-01 | 3.8e-01 | -5.40e-01 | 2.5e-01 | 1.71e+00 | 0.0e+00 | -7.30e-01 | 1.5e-01 | 2.84e+00 | 0.0e+00 |
CarbMet %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S24. Relative changes in the expression of genes involved in Carbohydrate metabolism after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))LipidMet%>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>%kable(caption = "Supplementary Table 25. Relative changes in the expression of genes involved in lipid metabolism after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(LipidMet$Adrenal_padj),F,ifelse(LipidMet$Adrenal_padj<.1,T,F)),color= ifelse(is.na(LipidMet$Adrenal_padj),"gray",ifelse(LipidMet$Adrenal_padj<.1,spec_color(LipidMet$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(LipidMet$HT_padj),F,ifelse(LipidMet$HT_padj<.1,T,F)),color= ifelse(is.na(LipidMet$HT_padj),"gray",ifelse(LipidMet$HT_padj<.1,spec_color(LipidMet$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(LipidMet$Liver_padj),F,ifelse(LipidMet$Liver_padj<.1,T,F)),color= ifelse(is.na(LipidMet$Liver_padj),"gray",ifelse(LipidMet$Liver_padj<.1,spec_color(LipidMet$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(LipidMet$Lung_padj),F,ifelse(LipidMet$Lung_padj<.1,T,F)),color= ifelse(is.na(LipidMet$Lung_padj),"gray",ifelse(LipidMet$Lung_padj <.1,spec_color(LipidMet$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(LipidMet$Adipose_padj),F,ifelse(LipidMet$Adipose_padj<.1,T,F)),color= ifelse(is.na(LipidMet$Adipose_padj),"gray",ifelse(LipidMet$Adipose_padj<.1, spec_color(LipidMet$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(LipidMet$Muscle_padj),F,ifelse(LipidMet$Muscle_padj<.1,T,F)),color= ifelse(is.na(LipidMet$Muscle_padj),"gray",ifelse(LipidMet$Muscle_padj<.1,spec_color(LipidMet$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 346 | Ugt8 | -1.80e-01 | NA | -1.90e-01 | 4.4e-01 | -6.50e-01 | 3.0e-01 | 8.00e-02 | NA | 4.70e-01 | NA | -2.64e+00 | 0.0e+00 |
| 30 | Agmo | -3.30e-01 | 1.5e-01 | -1.00e-02 | 9.9e-01 | -7.60e-01 | 1.1e-01 | -1.60e-01 | 3.8e-01 | -1.60e-01 | 7.6e-01 | -2.46e+00 | 0.0e+00 |
| 252 | Pla2g4a | -2.60e-01 | 1.5e-01 | -3.30e-01 | 3.6e-01 | -4.40e-01 | 4.3e-01 | -6.70e-01 | 2.0e-02 | -3.60e-01 | 4.6e-01 | -2.25e+00 | 0.0e+00 |
| 103 | Elovl7 | -2.60e-01 | 3.8e-01 | -6.80e-01 | 1.0e-02 | -6.50e-01 | 1.0e-02 | -2.70e-01 | 7.5e-01 | -4.10e-01 | 5.2e-01 | -2.01e+00 | 0.0e+00 |
| 298 | Scd2 | 4.00e-02 | 8.5e-01 | 6.00e-02 | 8.4e-01 | -7.60e-01 | 1.0e-02 | -3.90e-01 | 4.9e-01 | 3.10e-01 | 6.4e-01 | -1.95e+00 | 0.0e+00 |
| 333 | Tecrl | -5.90e-01 | 1.7e-01 | 1.00e-02 | NA | NA | NA | -6.00e-02 | NA | -2.10e-01 | NA | -1.91e+00 | 0.0e+00 |
| 34 | Ahr | -3.70e-01 | 8.0e-02 | -8.40e-01 | 0.0e+00 | -2.90e-01 | 5.1e-01 | -1.80e-01 | 7.9e-01 | -3.70e-01 | 4.0e-01 | -1.87e+00 | 0.0e+00 |
| 56 | Bdh1 | -2.70e-01 | 4.0e-01 | 3.00e-02 | 9.5e-01 | -4.80e-01 | 0.0e+00 | -2.30e-01 | 3.0e-02 | -8.00e-02 | 9.1e-01 | -1.78e+00 | 0.0e+00 |
| 215 | Olah | -1.00e-02 | 9.9e-01 | 1.40e-01 | NA | -1.56e+00 | 0.0e+00 | -1.90e-01 | NA | 4.80e-01 | 4.0e-01 | -1.76e+00 | 1.0e-02 |
| 233 | Pik3c2g | -5.70e-01 | 1.0e-01 | 1.00e-01 | 8.9e-01 | -5.00e-01 | 4.6e-01 | 2.80e-01 | 3.6e-01 | -6.10e-01 | 1.9e-01 | -1.70e+00 | 0.0e+00 |
| 110 | Fa2h | 1.80e-01 | 6.8e-01 | -1.40e-01 | 6.4e-01 | -3.30e-01 | 6.5e-01 | -8.00e-02 | NA | 4.10e-01 | 4.6e-01 | -1.64e+00 | 1.0e-02 |
| 82 | Cyp1b1 | 4.40e-01 | 1.2e-01 | -1.60e-01 | 7.9e-01 | 4.70e-01 | 2.2e-01 | 1.00e-01 | 9.3e-01 | 2.10e-01 | 5.4e-01 | -1.62e+00 | 0.0e+00 |
| 35 | Ahrr | -4.10e-01 | 3.2e-01 | 1.30e-01 | NA | -3.30e-01 | NA | -4.00e-02 | NA | -6.60e-01 | 2.1e-01 | -1.60e+00 | 1.0e-02 |
| 163 | Hsd3b7 | -1.00e-02 | 9.8e-01 | -1.70e-01 | 7.8e-01 | -9.00e-01 | 3.0e-02 | -4.40e-01 | 3.6e-01 | -5.40e-01 | 1.5e-01 | -1.60e+00 | 0.0e+00 |
| 183 | Mboat2 | -2.60e-01 | 1.3e-01 | -3.00e-02 | 9.3e-01 | 1.80e-01 | 6.5e-01 | -2.60e-01 | 7.5e-01 | 5.30e-01 | 3.6e-01 | -1.59e+00 | 0.0e+00 |
| 45 | Ankrd1 | -7.10e-01 | 2.0e-02 | 2.00e-02 | NA | 3.40e-01 | 6.3e-01 | -4.60e-01 | 4.7e-01 | 1.00e-02 | 9.9e-01 | -1.57e+00 | 1.0e-02 |
| 15 | Acer3 | -1.50e-01 | 4.4e-01 | -1.30e-01 | 8.0e-01 | -9.00e-02 | 8.9e-01 | -1.00e-02 | 9.9e-01 | 2.00e-02 | 9.7e-01 | -1.56e+00 | 0.0e+00 |
| 2 | Abca1 | 2.40e-01 | 3.1e-01 | -2.60e-01 | 4.6e-01 | 1.00e-01 | 8.8e-01 | -3.90e-01 | 2.6e-01 | -5.40e-01 | 3.0e-02 | -1.54e+00 | 0.0e+00 |
| 315 | Smpd3 | -9.70e-01 | 0.0e+00 | -2.30e-01 | 3.5e-01 | -9.00e-02 | 7.4e-01 | 2.00e-02 | 9.8e-01 | -2.30e-01 | 6.8e-01 | -1.53e+00 | 0.0e+00 |
| 290 | Ptgs2 | 9.50e-01 | 0.0e+00 | -3.40e-01 | 2.8e-01 | 4.20e-01 | 3.8e-01 | -2.60e-01 | 7.7e-01 | 4.00e-01 | 5.2e-01 | -1.49e+00 | 0.0e+00 |
| 289 | Ptgis | 4.30e-01 | 0.0e+00 | 1.00e-02 | 9.9e-01 | 5.00e-01 | 2.5e-01 | 7.20e-01 | 1.2e-01 | 4.00e-02 | 9.7e-01 | -1.48e+00 | 0.0e+00 |
| 259 | Plekha4 | 2.60e-01 | 3.0e-01 | 6.00e-02 | 9.3e-01 | 1.10e-01 | 8.2e-01 | 1.04e+00 | 0.0e+00 | 1.00e-02 | 9.9e-01 | -1.46e+00 | 0.0e+00 |
| 318 | Spp1 | 3.10e-01 | 4.4e-01 | -1.60e-01 | 8.1e-01 | -3.00e-01 | 3.0e-01 | 3.60e-01 | 6.3e-01 | 5.20e-01 | NA | -1.46e+00 | 1.0e-02 |
| 249 | Pla2g2a | 3.90e-01 | 3.9e-01 | 3.00e-02 | NA | -2.70e-01 | NA | -3.30e-01 | NA | -2.10e-01 | 6.8e-01 | -1.45e+00 | 1.0e-02 |
| 65 | Cers6 | -7.30e-01 | 2.0e-02 | -2.20e-01 | 7.0e-01 | -3.60e-01 | 4.6e-01 | -1.39e+00 | 0.0e+00 | 0.00e+00 | 1.0e+00 | -1.44e+00 | 0.0e+00 |
| 339 | Tnfaip8l3 | -6.50e-01 | 0.0e+00 | 3.00e-02 | 9.8e-01 | -3.80e-01 | 4.3e-01 | -1.00e-01 | 9.0e-01 | -3.70e-01 | 5.3e-01 | -1.41e+00 | 1.0e-02 |
| 164 | Inpp4b | -3.00e-02 | 9.6e-01 | -1.90e-01 | 6.4e-01 | -8.50e-01 | 1.0e-02 | -4.80e-01 | 3.4e-01 | -6.50e-01 | 6.0e-02 | -1.40e+00 | 0.0e+00 |
| 101 | Elovl4 | 2.00e-02 | 9.8e-01 | 5.00e-02 | 9.2e-01 | 6.60e-01 | 8.0e-02 | -2.00e-02 | NA | 1.24e+00 | 0.0e+00 | -1.36e+00 | 4.0e-02 |
| 311 | Slc44a1 | -2.60e-01 | 2.3e-01 | 1.30e-01 | 5.1e-01 | -4.50e-01 | 3.2e-01 | -1.50e-01 | 8.2e-01 | -9.00e-02 | 8.2e-01 | -1.33e+00 | 0.0e+00 |
| 139 | Gpam | -2.20e-01 | 2.7e-01 | -3.90e-01 | 1.3e-01 | -9.50e-01 | 0.0e+00 | -4.50e-01 | 2.0e-01 | -1.11e+00 | 0.0e+00 | -1.32e+00 | 0.0e+00 |
| 235 | Pik3cg | -3.50e-01 | 8.0e-02 | -4.10e-01 | 2.5e-01 | -2.50e-01 | 4.1e-01 | -5.60e-01 | 1.8e-01 | -6.80e-01 | 3.0e-02 | -1.32e+00 | 0.0e+00 |
| 47 | Arnt2 | -7.80e-01 | 0.0e+00 | -5.00e-02 | 8.7e-01 | 1.00e-02 | 9.8e-01 | -2.40e-01 | 7.8e-01 | -5.00e-02 | 9.5e-01 | -1.32e+00 | 4.0e-02 |
| 288 | Ptges | -2.10e-01 | 7.1e-01 | -7.00e-02 | 9.3e-01 | -6.00e-02 | 9.1e-01 | -2.00e-02 | NA | -3.60e-01 | 4.9e-01 | -1.31e+00 | 0.0e+00 |
| 256 | Pla2g5 | 9.00e-02 | 8.8e-01 | 1.50e-01 | 8.1e-01 | 4.60e-01 | 5.1e-01 | 1.00e-02 | NA | -5.10e-01 | 3.7e-01 | -1.28e+00 | 1.0e-02 |
| 248 | Pla2g12a | 7.20e-01 | 0.0e+00 | 3.70e-01 | 0.0e+00 | 4.00e-02 | 9.0e-01 | 1.64e+00 | 0.0e+00 | 7.00e-01 | 0.0e+00 | -1.28e+00 | 0.0e+00 |
| 210 | Npas2 | 5.00e-02 | 8.6e-01 | 2.70e-01 | 3.0e-01 | -3.40e-01 | 3.8e-01 | -2.30e-01 | 6.7e-01 | -3.00e-02 | 9.6e-01 | -1.27e+00 | 0.0e+00 |
| 41 | Alox5 | 6.00e-02 | 7.7e-01 | -4.60e-01 | 1.9e-01 | -1.00e-02 | 9.7e-01 | -2.30e-01 | 8.1e-01 | -2.60e-01 | 4.6e-01 | -1.27e+00 | 0.0e+00 |
| 254 | Pla2g4e | -2.30e-01 | 6.6e-01 | 0.00e+00 | 1.0e+00 | -1.10e-01 | NA | NA | NA | -1.00e-01 | NA | -1.25e+00 | 1.0e-02 |
| 107 | Esyt3 | -3.80e-01 | 0.0e+00 | -1.70e-01 | 5.2e-01 | 1.42e+00 | 0.0e+00 | -4.00e-02 | 9.8e-01 | -8.00e-02 | 9.1e-01 | -1.24e+00 | 3.0e-02 |
| 232 | Pik3c2b | -7.70e-01 | 0.0e+00 | -7.30e-01 | 0.0e+00 | -5.40e-01 | 1.7e-01 | -5.90e-01 | 2.1e-01 | -9.20e-01 | 0.0e+00 | -1.22e+00 | 0.0e+00 |
| 116 | Fads2 | -1.50e-01 | 5.7e-01 | 2.00e-02 | 9.7e-01 | -3.50e-01 | 0.0e+00 | -5.00e-01 | 1.2e-01 | 1.70e-01 | 7.2e-01 | -1.21e+00 | 0.0e+00 |
| 319 | Sptlc3 | -2.00e-02 | 9.7e-01 | -1.40e-01 | 8.2e-01 | -7.00e-02 | NA | NA | NA | -1.60e-01 | NA | -1.21e+00 | 9.0e-02 |
| 111 | Faah | -4.90e-01 | 2.0e-02 | 9.00e-02 | 8.3e-01 | -1.80e-01 | 5.5e-01 | -4.00e-02 | 8.9e-01 | -2.50e-01 | 7.3e-01 | -1.20e+00 | 8.0e-02 |
| 265 | Plpp2 | -5.00e-02 | 9.0e-01 | -4.00e-02 | 9.6e-01 | -5.00e-01 | 2.2e-01 | 3.00e-02 | 9.8e-01 | -4.20e-01 | 4.8e-01 | -1.18e+00 | 1.0e-01 |
| 338 | Tnfaip8l2 | 3.00e-02 | 9.4e-01 | 7.00e-02 | 9.3e-01 | 3.00e-01 | 5.5e-01 | -2.20e-01 | 7.1e-01 | -1.40e-01 | 8.1e-01 | -1.17e+00 | 0.0e+00 |
| 334 | Them5 | -3.10e-01 | 1.2e-01 | -2.80e-01 | NA | 9.30e-01 | 4.0e-02 | -2.00e-01 | 7.8e-01 | 2.40e-01 | NA | -1.17e+00 | 1.1e-01 |
| 292 | Rgl1 | 1.50e-01 | 1.4e-01 | -6.00e-02 | 8.0e-01 | -5.00e-01 | 0.0e+00 | -3.10e-01 | 2.2e-01 | 7.00e-02 | 8.6e-01 | -1.16e+00 | 0.0e+00 |
| 217 | Osbpl3 | -6.40e-01 | 1.0e-02 | -2.20e-01 | 5.2e-01 | -6.60e-01 | 0.0e+00 | 2.20e-01 | 6.2e-01 | -1.00e-02 | 9.9e-01 | -1.13e+00 | 0.0e+00 |
| 167 | Inpp5j | -5.70e-01 | 5.0e-02 | 1.20e-01 | 7.9e-01 | -1.92e+00 | 0.0e+00 | 0.00e+00 | NA | -6.20e-01 | 2.6e-01 | -1.12e+00 | 0.0e+00 |
| 332 | Tbxas1 | -8.00e-02 | 7.5e-01 | -5.10e-01 | 9.0e-02 | -5.30e-01 | 1.3e-01 | 2.10e-01 | 7.3e-01 | 4.00e-02 | 9.5e-01 | -1.12e+00 | 1.0e-02 |
| 119 | Far1 | -1.80e-01 | 4.9e-01 | -2.90e-01 | 4.4e-01 | -9.00e-02 | 8.9e-01 | -3.90e-01 | 5.2e-01 | 0.00e+00 | 1.0e+00 | -1.10e+00 | 0.0e+00 |
| 53 | B3galnt1 | 1.10e-01 | 5.9e-01 | -5.00e-02 | 9.3e-01 | 1.50e-01 | 6.6e-01 | 1.30e-01 | 9.2e-01 | 4.00e-02 | 9.4e-01 | -1.10e+00 | 0.0e+00 |
| 127 | Fhl2 | 3.90e-01 | 6.0e-02 | 7.00e-02 | 9.2e-01 | -1.30e-01 | 5.0e-01 | 2.90e-01 | 5.6e-01 | 7.30e-01 | 1.0e-02 | -1.08e+00 | 1.0e-01 |
| 174 | Lpcat2 | 8.00e-02 | 6.1e-01 | -1.10e-01 | 7.2e-01 | 9.40e-01 | 0.0e+00 | -3.30e-01 | 4.7e-01 | -2.90e-01 | 4.3e-01 | -1.08e+00 | 0.0e+00 |
| 263 | Plin1 | -2.20e-01 | 2.8e-01 | 1.60e-01 | NA | 2.10e-01 | 7.0e-01 | -1.10e-01 | 9.1e-01 | 4.00e-02 | 9.4e-01 | -1.08e+00 | 4.0e-02 |
| 277 | Pparg | -4.30e-01 | 1.0e-02 | -1.20e-01 | NA | -1.60e-01 | 7.1e-01 | -4.20e-01 | 2.0e-01 | -6.80e-01 | 1.0e-02 | -1.07e+00 | 0.0e+00 |
| 264 | Plin3 | -4.00e-02 | 8.6e-01 | -3.20e-01 | 5.1e-01 | -1.42e+00 | 0.0e+00 | 3.80e-01 | 8.0e-02 | -3.50e-01 | 2.0e-01 | -1.06e+00 | 0.0e+00 |
| 240 | Pip4k2a | -2.90e-01 | 1.0e-02 | 0.00e+00 | 1.0e+00 | -2.90e-01 | 7.0e-02 | -5.80e-01 | 7.0e-02 | -2.90e-01 | 2.7e-01 | -1.05e+00 | 0.0e+00 |
| 102 | Elovl5 | 1.00e-02 | 9.3e-01 | -5.00e-02 | 8.9e-01 | 9.00e-01 | 0.0e+00 | 2.80e-01 | 3.0e-01 | 1.70e-01 | 7.0e-01 | -1.05e+00 | 0.0e+00 |
| 182 | Mboat1 | 5.00e-02 | 7.7e-01 | -9.00e-02 | 8.9e-01 | -1.80e-01 | 6.8e-01 | -4.80e-01 | 1.2e-01 | -4.20e-01 | 3.8e-01 | -1.04e+00 | 1.0e-02 |
| 279 | Ppargc1b | -9.30e-01 | 0.0e+00 | -4.00e-01 | 3.4e-01 | 3.30e-01 | 6.1e-01 | 1.99e+00 | 0.0e+00 | 1.90e-01 | 7.0e-01 | -1.04e+00 | 0.0e+00 |
| 345 | Ugcg | 6.00e-02 | 7.9e-01 | -2.00e-02 | 9.7e-01 | -6.80e-01 | 3.0e-02 | -3.90e-01 | 3.2e-01 | -4.00e-02 | 9.5e-01 | -1.02e+00 | 0.0e+00 |
| 39 | Alox12 | -3.40e-01 | 2.1e-01 | -3.10e-01 | 5.2e-01 | 2.80e-01 | 6.8e-01 | 1.50e-01 | 8.8e-01 | 1.31e+00 | 0.0e+00 | -1.02e+00 | 8.0e-02 |
| 208 | Nfya | -9.80e-01 | 0.0e+00 | -7.00e-01 | 0.0e+00 | -7.50e-01 | 0.0e+00 | -7.30e-01 | 0.0e+00 | -5.10e-01 | 4.0e-02 | -1.01e+00 | 0.0e+00 |
| 137 | Gltp | 1.60e-01 | 1.8e-01 | -8.00e-02 | 8.8e-01 | 8.10e-01 | 0.0e+00 | -7.00e-02 | 9.0e-01 | -8.00e-02 | 8.7e-01 | -1.01e+00 | 0.0e+00 |
| 301 | Sec24d | 1.90e-01 | 5.0e-02 | 2.00e-02 | 9.7e-01 | 2.20e-01 | 3.7e-01 | 6.50e-01 | 0.0e+00 | 6.40e-01 | 0.0e+00 | -1.00e+00 | 0.0e+00 |
| 138 | Gm2a | 1.00e-01 | 2.4e-01 | 1.70e-01 | 5.5e-01 | 1.20e-01 | 3.6e-01 | -8.00e-02 | 6.7e-01 | 3.60e-01 | 2.0e-01 | -1.00e+00 | 0.0e+00 |
| 246 | Pkd2 | 2.00e-02 | 9.3e-01 | -2.70e-01 | 3.2e-01 | -4.20e-01 | 1.1e-01 | -1.80e-01 | 7.8e-01 | 2.80e-01 | 1.7e-01 | -1.00e+00 | 0.0e+00 |
| 4 | Abcc3 | -3.50e-01 | 0.0e+00 | -4.70e-01 | 1.3e-01 | -4.80e-01 | 0.0e+00 | -4.80e-01 | 2.7e-01 | -3.70e-01 | 6.0e-02 | -9.90e-01 | 0.0e+00 |
| 27 | Acsl5 | -7.00e-02 | 6.1e-01 | 5.00e-02 | 9.0e-01 | -5.00e-02 | 7.9e-01 | 1.40e-01 | 6.2e-01 | -4.00e-02 | 9.2e-01 | -9.80e-01 | 0.0e+00 |
| 24 | Acsf2 | 1.20e-01 | 5.8e-01 | 2.10e-01 | 5.4e-01 | -7.00e-02 | 9.1e-01 | -2.00e-02 | 9.8e-01 | -8.00e-02 | 8.5e-01 | -9.80e-01 | 0.0e+00 |
| 86 | Cyp39a1 | -2.30e-01 | 3.8e-01 | 1.00e-02 | 1.0e+00 | -6.20e-01 | 8.0e-02 | -1.70e-01 | 1.1e-01 | -8.00e-02 | 8.5e-01 | -9.80e-01 | 0.0e+00 |
| 40 | Alox15 | -1.70e-01 | 4.1e-01 | -8.00e-02 | 9.2e-01 | 8.00e-02 | 9.1e-01 | -9.00e-02 | 9.4e-01 | -5.20e-01 | 3.7e-01 | -9.60e-01 | 8.0e-02 |
| 273 | Pon2 | 3.00e-02 | 8.2e-01 | 1.60e-01 | 3.9e-01 | -3.10e-01 | 8.0e-02 | -4.00e-02 | 8.8e-01 | 3.20e-01 | 1.2e-01 | -9.40e-01 | 0.0e+00 |
| 91 | Cyp7b1 | 6.10e-01 | 5.0e-02 | -2.20e-01 | 6.0e-01 | -1.60e-01 | 8.1e-01 | -1.80e-01 | 7.5e-01 | -5.30e-01 | 2.6e-01 | -9.30e-01 | 3.0e-02 |
| 115 | Fads1 | -1.50e-01 | 1.7e-01 | 1.50e-01 | 3.8e-01 | -1.10e+00 | 0.0e+00 | -4.00e-01 | 7.0e-02 | 2.00e-01 | 7.0e-01 | -9.20e-01 | 0.0e+00 |
| 97 | Dpep2 | 1.50e-01 | 2.7e-01 | -1.00e-01 | 8.9e-01 | 1.70e-01 | 8.1e-01 | -4.00e-01 | 5.2e-01 | -1.60e-01 | 7.3e-01 | -9.20e-01 | 1.0e-02 |
| 266 | Plpp3 | -1.80e-01 | 1.3e-01 | -1.50e-01 | 5.2e-01 | 9.60e-01 | 0.0e+00 | 2.10e-01 | 3.2e-01 | 2.00e-02 | 9.6e-01 | -9.20e-01 | 0.0e+00 |
| 100 | Elovl1 | 2.50e-01 | 1.7e-01 | 3.00e-02 | 9.7e-01 | 1.20e-01 | 5.5e-01 | -4.00e-02 | 9.4e-01 | 1.00e-02 | 9.7e-01 | -9.10e-01 | 0.0e+00 |
| 141 | Gpat3 | 5.70e-01 | 0.0e+00 | 3.40e-01 | 1.3e-01 | 3.20e-01 | 4.3e-01 | 2.62e+00 | 0.0e+00 | 2.60e-01 | 3.1e-01 | -9.10e-01 | 0.0e+00 |
| 32 | Agpat2 | -8.00e-02 | 8.7e-01 | 6.00e-02 | 9.3e-01 | -3.20e-01 | 1.5e-01 | 1.60e-01 | 6.5e-01 | 2.10e-01 | 4.9e-01 | -9.00e-01 | 1.0e-02 |
| 72 | Cpne7 | -9.00e-02 | 7.7e-01 | 2.80e-01 | 3.0e-01 | 1.60e-01 | 7.2e-01 | -2.90e-01 | 6.5e-01 | -1.80e-01 | 7.4e-01 | -9.00e-01 | 7.0e-02 |
| 258 | Pld2 | -4.00e-02 | 8.2e-01 | -1.40e-01 | 5.1e-01 | -9.10e-01 | 0.0e+00 | -3.50e-01 | 4.8e-01 | -6.90e-01 | 0.0e+00 | -8.90e-01 | 0.0e+00 |
| 262 | Plekha8 | -4.20e-01 | 0.0e+00 | -4.90e-01 | 0.0e+00 | -1.90e-01 | 3.0e-01 | -5.10e-01 | 1.0e-02 | -4.50e-01 | 6.0e-02 | -8.90e-01 | 0.0e+00 |
| 29 | Acss3 | 1.60e-01 | 4.5e-01 | -1.60e-01 | 7.1e-01 | -2.90e-01 | 4.0e-01 | -2.30e-01 | 3.9e-01 | 1.50e-01 | 6.5e-01 | -8.90e-01 | 0.0e+00 |
| 51 | Arsi | -1.16e+00 | 0.0e+00 | -9.00e-02 | 9.0e-01 | 3.90e-01 | 5.5e-01 | -2.40e-01 | NA | -4.20e-01 | 4.9e-01 | -8.80e-01 | 5.0e-02 |
| 135 | Ggt5 | -2.20e-01 | 4.9e-01 | 1.20e-01 | 8.6e-01 | -1.00e-02 | 1.0e+00 | 5.00e-02 | 9.6e-01 | -2.50e-01 | 6.2e-01 | -8.70e-01 | 1.0e-02 |
| 6 | Abhd3 | -1.60e-01 | 5.1e-01 | -1.00e-02 | 9.9e-01 | -3.10e-01 | 1.7e-01 | -3.50e-01 | 5.9e-01 | -1.40e-01 | 6.7e-01 | -8.60e-01 | 0.0e+00 |
| 309 | Slc27a1 | -5.00e-02 | 7.8e-01 | 8.00e-02 | 7.0e-01 | 1.40e-01 | 6.0e-01 | 8.00e-02 | 7.4e-01 | -5.30e-01 | 7.0e-02 | -8.60e-01 | 0.0e+00 |
| 96 | Dhcr7 | -3.30e-01 | 9.0e-02 | 1.50e-01 | 7.8e-01 | -4.40e-01 | 1.8e-01 | 1.90e-01 | 6.0e-01 | 1.50e-01 | 8.0e-01 | -8.60e-01 | 4.0e-02 |
| 38 | Alb | -5.90e-01 | 6.0e-02 | 2.00e-02 | 9.7e-01 | -4.80e-01 | 4.3e-01 | 1.10e-01 | 7.3e-01 | 3.10e-01 | 5.3e-01 | -8.60e-01 | 1.6e-01 |
| 28 | Acsm3 | -4.10e-01 | 2.6e-01 | -4.00e-02 | 9.7e-01 | -2.20e-01 | 7.6e-01 | 3.50e-01 | 5.2e-01 | -2.40e-01 | 7.1e-01 | -8.50e-01 | 4.0e-02 |
| 166 | Inpp5f | -2.50e-01 | 3.0e-02 | -7.00e-02 | 8.3e-01 | -4.40e-01 | 1.0e-02 | -6.00e-02 | 7.9e-01 | -2.90e-01 | 2.2e-01 | -8.40e-01 | 0.0e+00 |
| 341 | Tpte2 | 1.00e-01 | NA | -1.60e-01 | NA | -2.70e-01 | NA | 4.49e+00 | 0.0e+00 | 6.00e-02 | 9.5e-01 | -8.30e-01 | 2.7e-01 |
| 310 | Slc27a3 | -3.00e-01 | 3.5e-01 | 4.00e-02 | 9.3e-01 | -4.90e-01 | 1.5e-01 | -2.40e-01 | 7.9e-01 | -1.50e-01 | 7.8e-01 | -8.20e-01 | 8.0e-02 |
| 250 | Pla2g2d | 2.70e-01 | 3.0e-02 | -4.60e-01 | 2.5e-01 | 2.50e-01 | 3.7e-01 | 2.10e-01 | 7.5e-01 | 8.00e-02 | 8.7e-01 | -8.20e-01 | 0.0e+00 |
| 68 | Cidec | -3.00e-01 | 5.2e-01 | 3.00e-02 | NA | 1.07e+00 | 0.0e+00 | 6.50e-01 | 0.0e+00 | 1.31e+00 | 0.0e+00 | -8.10e-01 | 1.5e-01 |
| 160 | Hsd17b4 | 1.60e-01 | 3.8e-01 | -1.00e-01 | 8.2e-01 | -7.00e-02 | 8.0e-01 | 4.00e-02 | 9.2e-01 | 2.20e-01 | 5.7e-01 | -8.10e-01 | 0.0e+00 |
| 230 | Pi4k2b | 5.10e-01 | 0.0e+00 | -2.30e-01 | 5.9e-01 | -7.00e-02 | 8.8e-01 | -1.40e-01 | 7.5e-01 | 6.10e-01 | 2.0e-02 | -8.10e-01 | 0.0e+00 |
| 19 | Acot7 | 1.70e-01 | 5.3e-01 | 4.00e-02 | 9.6e-01 | -3.10e-01 | 4.9e-01 | 2.10e-01 | 6.0e-01 | -1.00e-02 | 9.9e-01 | -8.00e-01 | 0.0e+00 |
| 196 | Msmo1 | -1.50e-01 | 2.6e-01 | 2.00e-01 | 6.1e-01 | -4.90e-01 | 6.0e-02 | -8.00e-01 | 0.0e+00 | -1.00e-01 | 8.2e-01 | -8.00e-01 | 0.0e+00 |
| 330 | Synj1 | -1.60e-01 | 5.7e-01 | -1.40e-01 | 7.7e-01 | -4.50e-01 | 1.0e-02 | 5.00e-02 | 9.5e-01 | -1.00e-02 | 9.8e-01 | -8.00e-01 | 0.0e+00 |
| 326 | Stard3nl | 2.00e-02 | 9.1e-01 | 8.00e-02 | 9.0e-01 | -6.70e-01 | 2.0e-02 | -1.50e-01 | 6.3e-01 | -2.00e-02 | 9.6e-01 | -7.90e-01 | 0.0e+00 |
| 342 | Tram1 | 1.50e-01 | 9.0e-02 | 0.00e+00 | 9.9e-01 | 2.80e-01 | 0.0e+00 | -2.00e-02 | 9.7e-01 | 1.00e-01 | 7.2e-01 | -7.90e-01 | 0.0e+00 |
| 64 | Cers4 | -4.30e-01 | 1.0e-01 | -2.50e-01 | 5.7e-01 | -2.90e-01 | 4.5e-01 | -2.20e-01 | 7.9e-01 | -9.00e-02 | 8.4e-01 | -7.90e-01 | 3.0e-02 |
| 50 | Arsg | -9.00e-02 | 5.8e-01 | 9.00e-02 | 5.9e-01 | -1.90e-01 | 3.8e-01 | 1.90e-01 | 4.8e-01 | 3.00e-02 | 9.4e-01 | -7.70e-01 | 0.0e+00 |
| 165 | Inpp5d | 2.10e-01 | 1.2e-01 | -3.00e-02 | 9.3e-01 | -4.30e-01 | 7.0e-02 | -3.40e-01 | 2.3e-01 | -2.60e-01 | 4.9e-01 | -7.70e-01 | 0.0e+00 |
| 336 | Tnfaip8 | 6.00e-02 | 7.7e-01 | -1.40e-01 | 7.5e-01 | -5.00e-02 | 9.2e-01 | 3.60e-01 | 4.3e-01 | -4.00e-02 | 9.5e-01 | -7.70e-01 | 1.0e-02 |
| 237 | Pik3r3 | -3.00e-01 | 1.7e-01 | -2.10e-01 | 5.9e-01 | -3.20e-01 | 2.2e-01 | 1.20e-01 | 9.2e-01 | 2.00e-02 | 9.8e-01 | -7.70e-01 | 5.0e-02 |
| 257 | Pld1 | -4.00e-02 | 8.6e-01 | -3.80e-01 | 7.0e-02 | -4.20e-01 | 6.0e-02 | -9.50e-01 | 0.0e+00 | -4.50e-01 | 2.0e-02 | -7.60e-01 | 0.0e+00 |
| 98 | Ebp | -2.00e-01 | 2.4e-01 | -3.00e-02 | 9.7e-01 | -4.50e-01 | 1.0e-02 | -1.60e-01 | 5.0e-01 | 1.10e-01 | 7.8e-01 | -7.60e-01 | 2.0e-02 |
| 148 | Hacd2 | -4.00e-02 | 9.0e-01 | 9.00e-02 | 7.9e-01 | -1.70e-01 | 4.4e-01 | 2.00e-02 | 9.8e-01 | 1.00e-02 | 9.9e-01 | -7.50e-01 | 1.0e-02 |
| 327 | Stard7 | -6.00e-02 | 7.4e-01 | 2.00e-02 | 9.7e-01 | -6.00e-02 | 8.8e-01 | 6.50e-01 | 0.0e+00 | -2.00e-02 | 9.6e-01 | -7.40e-01 | 0.0e+00 |
| 296 | Sacm1l | -6.00e-02 | 7.9e-01 | -2.50e-01 | 3.1e-01 | 2.80e-01 | 5.6e-01 | -9.00e-02 | 7.9e-01 | 5.00e-02 | 9.3e-01 | -7.20e-01 | 0.0e+00 |
| 260 | Plekha5 | -1.30e-01 | 3.2e-01 | -1.40e-01 | 5.7e-01 | -1.40e-01 | 4.2e-01 | -2.50e-01 | 6.0e-02 | -2.00e-01 | 5.8e-01 | -7.20e-01 | 0.0e+00 |
| 305 | Sgpp1 | -1.00e-02 | 9.6e-01 | 1.10e-01 | 8.2e-01 | 2.90e-01 | 5.1e-01 | 0.00e+00 | 1.0e+00 | -5.00e-02 | 9.3e-01 | -7.20e-01 | 0.0e+00 |
| 25 | Acsl1 | -5.20e-01 | 2.3e-01 | -3.00e-02 | 9.3e-01 | 5.70e-01 | 1.0e-02 | -3.00e-02 | 9.4e-01 | 1.90e-01 | 5.3e-01 | -7.20e-01 | 0.0e+00 |
| 7 | Abhd5 | -9.00e-02 | 5.2e-01 | -2.40e-01 | 3.1e-01 | -5.20e-01 | 2.0e-02 | -1.13e+00 | 0.0e+00 | -6.00e-02 | 9.0e-01 | -7.20e-01 | 0.0e+00 |
| 106 | Esyt1 | -1.50e-01 | 4.0e-01 | -2.10e-01 | 5.7e-01 | -6.00e-02 | 6.8e-01 | -2.30e-01 | 2.4e-01 | -9.00e-02 | 7.1e-01 | -7.10e-01 | 0.0e+00 |
| 303 | Sgms2 | -3.40e-01 | 1.6e-01 | -3.70e-01 | 3.5e-01 | 2.70e+00 | 0.0e+00 | -4.40e-01 | 3.2e-01 | -3.90e-01 | 2.1e-01 | -7.10e-01 | 1.1e-01 |
| 70 | Cpne3 | -3.40e-01 | 2.4e-01 | -1.30e-01 | 8.1e-01 | -4.30e-01 | 4.5e-01 | -2.00e-01 | 7.9e-01 | 1.20e-01 | 8.4e-01 | -7.00e-01 | 0.0e+00 |
| 222 | Oxct1 | -3.80e-01 | 8.0e-02 | -1.20e-01 | 7.7e-01 | 8.00e-02 | 8.5e-01 | -5.40e-01 | 3.6e-01 | -6.00e-02 | 8.9e-01 | -7.00e-01 | 0.0e+00 |
| 158 | Hsd17b12 | 1.90e-01 | 3.2e-01 | 1.00e-01 | 7.5e-01 | 0.00e+00 | 1.0e+00 | 7.00e-02 | 7.6e-01 | 3.40e-01 | 1.8e-01 | -6.80e-01 | 0.0e+00 |
| 49 | Arsb | 1.20e-01 | 2.1e-01 | 2.00e-02 | 9.4e-01 | 8.50e-01 | 0.0e+00 | 3.40e-01 | 2.0e-02 | -2.00e-01 | 3.8e-01 | -6.80e-01 | 0.0e+00 |
| 285 | Prkd1 | 5.00e-02 | 7.7e-01 | 1.00e-02 | 9.9e-01 | -1.20e-01 | 7.5e-01 | 1.70e-01 | 8.7e-01 | -5.50e-01 | 0.0e+00 | -6.70e-01 | 0.0e+00 |
| 60 | Cd36 | 3.20e-01 | 7.0e-02 | -1.70e-01 | 7.7e-01 | -2.00e-01 | 4.6e-01 | 6.00e-02 | 9.2e-01 | 1.90e-01 | 6.0e-01 | -6.60e-01 | 1.0e-02 |
| 131 | G0s2 | -1.41e+00 | 0.0e+00 | -3.20e-01 | 5.0e-01 | 3.30e-01 | 5.5e-01 | 4.80e-01 | 2.6e-01 | 3.10e-01 | 5.2e-01 | -6.60e-01 | 8.0e-02 |
| 173 | Lpcat1 | -1.40e-01 | 4.1e-01 | -8.00e-02 | 6.7e-01 | -1.10e-01 | 8.1e-01 | -4.00e-01 | 5.6e-01 | -4.50e-01 | 9.0e-02 | -6.60e-01 | 1.0e-02 |
| 10 | Acadl | 6.00e-02 | 9.0e-01 | 1.90e-01 | 5.8e-01 | 1.80e-01 | 5.6e-01 | 1.70e-01 | 5.0e-01 | 4.30e-01 | 2.0e-02 | -6.50e-01 | 0.0e+00 |
| 42 | Aloxe3 | 9.00e-02 | 8.6e-01 | 1.60e-01 | 6.5e-01 | 1.49e+00 | 0.0e+00 | 6.60e-01 | 2.4e-01 | 4.10e-01 | NA | -6.30e-01 | 4.0e-01 |
| 134 | Gdpd1 | -5.00e-02 | 8.3e-01 | -2.00e-02 | 9.8e-01 | 4.70e-01 | 2.8e-01 | -5.70e-01 | 7.0e-02 | -2.60e-01 | 5.9e-01 | -6.30e-01 | 2.0e-02 |
| 245 | Pitpnm3 | -4.00e-02 | 7.8e-01 | -2.70e-01 | 2.0e-02 | 4.50e-01 | 1.3e-01 | -1.40e-01 | NA | -3.30e-01 | 4.4e-01 | -6.30e-01 | 3.0e-02 |
| 136 | Glb1l | 0.00e+00 | 1.0e+00 | -1.30e-01 | 7.5e-01 | -1.80e-01 | 6.1e-01 | 2.00e-02 | 9.8e-01 | 2.00e-02 | 9.7e-01 | -6.20e-01 | 3.0e-02 |
| 149 | Hacd3 | -4.00e-02 | 8.0e-01 | 1.20e-01 | 7.9e-01 | 9.00e-02 | 8.2e-01 | 4.90e-01 | 0.0e+00 | 3.20e-01 | 2.4e-01 | -6.10e-01 | 0.0e+00 |
| 59 | Cav1 | 2.50e-01 | 4.0e-02 | -4.00e-02 | 9.3e-01 | 6.80e-01 | 0.0e+00 | -2.00e-01 | NA | 2.50e-01 | 4.1e-01 | -6.00e-01 | 0.0e+00 |
| 20 | Acot8 | -1.30e-01 | 7.3e-01 | 1.40e-01 | 8.3e-01 | -7.40e-01 | NA | -7.00e-02 | 9.4e-01 | -3.00e-02 | 9.7e-01 | -6.00e-01 | 2.0e-02 |
| 216 | Osbpl2 | 1.00e-02 | 9.6e-01 | -1.00e-01 | 6.7e-01 | -4.10e-01 | 0.0e+00 | -2.00e-01 | 9.0e-02 | -4.10e-01 | 1.0e-02 | -5.90e-01 | 0.0e+00 |
| 117 | Fam120b | -2.00e-01 | 1.3e-01 | -1.00e-01 | 8.2e-01 | -4.60e-01 | 0.0e+00 | -1.30e-01 | 4.8e-01 | -2.70e-01 | 3.0e-01 | -5.90e-01 | 0.0e+00 |
| 187 | Med13 | -1.50e-01 | 7.1e-01 | -1.40e-01 | 8.4e-01 | 4.10e-01 | 3.7e-01 | -2.20e-01 | 7.8e-01 | 6.60e-01 | 2.0e-02 | -5.50e-01 | 5.0e-02 |
| 348 | Vdr | 1.70e-01 | 3.0e-01 | 5.70e-01 | 1.1e-01 | 6.30e-01 | 1.0e-02 | -7.00e-02 | 9.6e-01 | 1.00e+00 | 0.0e+00 | -5.30e-01 | 2.8e-01 |
| 22 | Acsbg1 | 1.23e+00 | 0.0e+00 | 2.20e-01 | 1.3e-01 | 1.50e-01 | 6.2e-01 | 6.00e-01 | 1.0e-01 | 3.10e-01 | 6.3e-01 | -5.20e-01 | 4.9e-01 |
| 156 | Hsd11b1 | 9.00e-02 | 5.9e-01 | 1.30e-01 | 8.0e-01 | 4.20e-01 | 0.0e+00 | 1.30e-01 | 6.8e-01 | 6.40e-01 | 0.0e+00 | -5.10e-01 | 3.0e-02 |
| 193 | Mid1ip1 | 1.20e-01 | 5.4e-01 | -9.00e-02 | 8.0e-01 | -9.70e-01 | 0.0e+00 | -1.45e+00 | 0.0e+00 | -3.40e-01 | 2.8e-01 | -5.10e-01 | 8.0e-02 |
| 16 | Acly | -2.00e-02 | 9.4e-01 | 1.30e-01 | 8.1e-01 | -4.70e-01 | 1.2e-01 | -4.90e-01 | 1.8e-01 | 8.00e-01 | 3.0e-02 | -5.00e-01 | 4.0e-02 |
| 122 | Fasn | 8.30e-01 | 0.0e+00 | 0.00e+00 | 9.9e-01 | -1.30e-01 | 8.2e-01 | -6.40e-01 | 7.0e-02 | -2.40e-01 | 7.4e-01 | -4.80e-01 | 2.3e-01 |
| 218 | Osbpl5 | -7.00e-02 | 7.7e-01 | -7.00e-02 | 8.4e-01 | -3.20e-01 | 1.1e-01 | -3.00e-02 | 9.8e-01 | 6.50e-01 | 0.0e+00 | -4.80e-01 | 0.0e+00 |
| 121 | Fas | -2.60e-01 | 1.2e-01 | -3.00e-01 | 4.4e-01 | -4.00e-01 | 3.2e-01 | -8.00e-01 | 1.0e-02 | -2.60e-01 | 5.1e-01 | -4.80e-01 | 1.3e-01 |
| 239 | Pik3r5 | -1.20e-01 | 5.0e-01 | 5.80e-01 | 2.0e-02 | 8.00e-01 | 1.0e-02 | 2.00e-02 | 9.9e-01 | -3.00e-02 | 9.7e-01 | -4.70e-01 | 3.4e-01 |
| 154 | Hpgd | -1.60e-01 | 5.9e-01 | 1.00e-01 | 9.0e-01 | -3.00e-01 | 5.9e-01 | -3.00e-02 | NA | 1.31e+00 | 0.0e+00 | -4.50e-01 | 3.3e-01 |
| 144 | Gpd1l | 0.00e+00 | 9.9e-01 | -1.70e-01 | 3.6e-01 | -3.90e-01 | 2.0e-02 | 7.10e-01 | 0.0e+00 | 6.50e-01 | 1.0e-02 | -4.40e-01 | 1.0e-02 |
| 54 | B4galnt1 | -2.70e-01 | 4.6e-01 | -1.30e-01 | 7.9e-01 | 7.00e-01 | 4.0e-02 | 6.30e-01 | 0.0e+00 | -4.00e-01 | 4.2e-01 | -4.40e-01 | 2.4e-01 |
| 286 | Prkd3 | -2.70e-01 | 3.6e-01 | -2.50e-01 | 5.5e-01 | -5.10e-01 | 7.0e-02 | -1.16e+00 | 0.0e+00 | -1.50e-01 | 6.5e-01 | -4.30e-01 | 7.0e-02 |
| 157 | Hsd11b2 | -6.70e-01 | 5.0e-02 | 1.60e-01 | 8.0e-01 | -6.00e-02 | 8.8e-01 | 3.10e-01 | 4.5e-01 | 6.80e-01 | 4.0e-02 | -4.20e-01 | 5.4e-01 |
| 123 | Fdft1 | -1.80e-01 | 7.0e-02 | 9.00e-02 | 8.2e-01 | -8.20e-01 | 0.0e+00 | -6.10e-01 | 0.0e+00 | -2.40e-01 | 6.2e-01 | -4.00e-01 | 2.0e-02 |
| 304 | Sgpl1 | -1.00e-01 | 5.5e-01 | -1.70e-01 | 5.4e-01 | 3.40e-01 | 4.0e-02 | -8.60e-01 | 0.0e+00 | -3.20e-01 | 2.0e-01 | -3.90e-01 | 5.0e-02 |
| 113 | Fabp3 | -8.20e-01 | 4.0e-02 | 2.70e-01 | 5.0e-01 | 4.70e-01 | 5.0e-01 | -4.20e-01 | 5.6e-01 | -4.90e-01 | 3.3e-01 | -3.70e-01 | 4.0e-01 |
| 108 | Etnk2 | 3.00e-02 | 9.6e-01 | 0.00e+00 | 1.0e+00 | -1.09e+00 | 0.0e+00 | 1.60e-01 | 7.5e-01 | 8.00e-02 | 9.3e-01 | -3.50e-01 | 6.7e-01 |
| 234 | Pik3cb | -9.00e-02 | 6.8e-01 | -1.60e-01 | 6.5e-01 | -1.80e-01 | 6.3e-01 | -1.40e-01 | 7.7e-01 | -1.17e+00 | 0.0e+00 | -3.00e-01 | 1.5e-01 |
| 337 | Tnfaip8l1 | -1.50e-01 | 7.6e-01 | -3.10e-01 | NA | 2.20e-01 | 7.5e-01 | -7.70e-01 | 0.0e+00 | -2.40e-01 | 7.3e-01 | -3.00e-01 | 7.0e-01 |
| 194 | Miga2 | -9.00e-02 | 7.3e-01 | 4.00e-02 | 9.3e-01 | 6.80e-01 | 0.0e+00 | 8.50e-01 | 0.0e+00 | 4.50e-01 | 2.0e-02 | -3.00e-01 | 1.0e-01 |
| 130 | Fitm2 | 2.00e-02 | 9.6e-01 | 1.10e-01 | 6.0e-01 | 2.30e-01 | 4.9e-01 | 7.60e-01 | 0.0e+00 | 1.70e-01 | 5.8e-01 | -3.00e-01 | 2.7e-01 |
| 104 | Ephx2 | -5.00e-02 | 9.1e-01 | 6.00e-02 | 9.2e-01 | -9.00e-02 | 8.7e-01 | 1.25e+00 | 0.0e+00 | -7.40e-01 | 0.0e+00 | -2.90e-01 | 3.9e-01 |
| 227 | Pex11a | 1.36e+00 | 0.0e+00 | 1.01e+00 | 0.0e+00 | -8.90e-01 | 0.0e+00 | 1.93e+00 | 0.0e+00 | -6.00e-02 | 9.0e-01 | -2.80e-01 | 3.3e-01 |
| 291 | Rac3 | 3.70e-01 | 3.8e-01 | 1.80e-01 | 7.1e-01 | -1.80e-01 | 8.3e-01 | 7.10e-01 | 1.0e-01 | -2.90e-01 | 6.7e-01 | -2.60e-01 | 7.5e-01 |
| 75 | Cpt2 | -8.00e-02 | 8.0e-01 | 2.70e-01 | 1.5e-01 | -2.40e-01 | 5.5e-01 | 8.50e-01 | 0.0e+00 | -2.70e-01 | 2.1e-01 | -2.50e-01 | 3.4e-01 |
| 195 | Mmaa | -5.80e-01 | 0.0e+00 | -2.60e-01 | 2.8e-01 | -7.00e-01 | 0.0e+00 | -2.60e-01 | 3.6e-01 | -1.00e-02 | 9.8e-01 | -2.40e-01 | 1.0e-01 |
| 21 | Acox2 | -8.20e-01 | 4.0e-02 | 1.00e-01 | 9.0e-01 | -8.40e-01 | 1.4e-01 | 1.40e-01 | 4.7e-01 | -6.00e-02 | 9.4e-01 | -2.40e-01 | 3.2e-01 |
| 322 | Srd5a1 | -4.30e-01 | 1.0e-02 | -2.00e-02 | 9.7e-01 | -7.80e-01 | 0.0e+00 | -1.30e-01 | 6.4e-01 | -2.10e-01 | 6.8e-01 | -2.40e-01 | 5.5e-01 |
| 176 | Lpin2 | 6.00e-01 | 0.0e+00 | -1.00e-01 | 6.8e-01 | 8.00e-02 | 7.4e-01 | 3.50e-01 | 2.8e-01 | 6.10e-01 | 0.0e+00 | -2.30e-01 | 1.5e-01 |
| 76 | Cptp | -3.50e-01 | 2.0e-02 | -1.30e-01 | 7.2e-01 | -5.30e-01 | 8.0e-02 | 3.40e-01 | 1.1e-01 | -7.50e-01 | 0.0e+00 | -2.10e-01 | 3.8e-01 |
| 244 | Pitpnb | 1.10e-01 | 2.4e-01 | 7.00e-02 | 8.6e-01 | 3.60e-01 | 1.3e-01 | 8.10e-01 | 0.0e+00 | 6.40e-01 | 0.0e+00 | -1.90e-01 | 1.7e-01 |
| 84 | Cyp27b1 | -3.00e-02 | 9.6e-01 | 2.70e-01 | NA | 8.50e-01 | 0.0e+00 | 2.20e-01 | NA | -4.00e-01 | 5.0e-01 | -1.70e-01 | 8.3e-01 |
| 33 | Agt | -2.60e-01 | 6.1e-01 | 2.70e-01 | 1.2e-01 | 1.10e+00 | 1.0e-02 | 8.70e-01 | 0.0e+00 | 1.07e+00 | 0.0e+00 | -1.70e-01 | 7.2e-01 |
| 242 | Pip5k1b | -3.00e-02 | 8.9e-01 | 3.00e-02 | 9.4e-01 | 4.90e-01 | 0.0e+00 | -5.30e-01 | 3.9e-01 | -7.70e-01 | 1.0e-02 | -1.70e-01 | 7.6e-01 |
| 226 | Pemt | -8.80e-01 | 2.0e-02 | 2.70e-01 | 5.9e-01 | -2.00e-01 | 5.6e-01 | -1.80e-01 | 5.8e-01 | 2.60e-01 | 4.6e-01 | -1.60e-01 | 7.8e-01 |
| 251 | Pla2g3 | 6.00e-02 | 9.3e-01 | 2.58e+00 | 0.0e+00 | -3.60e-01 | 6.2e-01 | 3.00e-02 | NA | 5.00e-02 | NA | -1.50e-01 | NA |
| 150 | Hacl1 | -4.60e-01 | 0.0e+00 | -1.30e-01 | 7.2e-01 | -5.70e-01 | 0.0e+00 | -6.90e-01 | 1.0e-02 | -3.60e-01 | 8.0e-02 | -1.50e-01 | 5.5e-01 |
| 153 | Hmgcs1 | -2.00e-01 | 9.0e-02 | 1.00e-01 | 7.3e-01 | -1.29e+00 | 0.0e+00 | -9.30e-01 | 0.0e+00 | -1.30e-01 | 7.0e-01 | -1.30e-01 | 2.8e-01 |
| 3 | Abcb11 | -6.60e-01 | 7.0e-02 | -2.00e-02 | 9.8e-01 | -5.20e-01 | 4.0e-01 | 2.60e-01 | 1.1e-01 | 2.00e-01 | 7.5e-01 | -1.30e-01 | NA |
| 67 | Cidea | -6.50e-01 | 1.0e-01 | 1.90e-01 | NA | 3.00e-01 | 5.9e-01 | 4.80e-01 | 3.5e-01 | 4.00e-01 | 4.0e-01 | -1.30e-01 | 8.8e-01 |
| 169 | Insig2 | 5.00e-02 | 8.6e-01 | -1.00e-01 | 8.5e-01 | -3.40e-01 | 2.9e-01 | -6.60e-01 | 1.0e-02 | 1.20e-01 | 7.1e-01 | -1.30e-01 | 4.8e-01 |
| 192 | Mfsd2a | 3.60e-01 | 3.0e-01 | 1.46e+00 | 0.0e+00 | -5.60e-01 | 3.3e-01 | 1.73e+00 | 0.0e+00 | 2.35e+00 | 0.0e+00 | -1.20e-01 | NA |
| 261 | Plekha6 | -6.90e-01 | 0.0e+00 | -1.50e-01 | 5.5e-01 | 1.70e-01 | 4.6e-01 | 6.00e-01 | 0.0e+00 | -3.80e-01 | 1.9e-01 | -1.20e-01 | 6.8e-01 |
| 23 | Acsbg2 | -5.00e-02 | NA | 1.80e-01 | NA | 6.40e-01 | 2.8e-01 | NA | NA | 8.60e-01 | 0.0e+00 | -1.20e-01 | NA |
| 132 | Galc | 1.70e-01 | 3.9e-01 | 8.00e-02 | 8.5e-01 | -9.00e-02 | 7.3e-01 | 6.70e-01 | 2.0e-02 | 3.00e-01 | 4.3e-01 | -1.10e-01 | 8.4e-01 |
| 209 | Nfyb | -3.90e-01 | 0.0e+00 | -1.00e-02 | 9.9e-01 | -5.30e-01 | 5.0e-02 | -8.20e-01 | 0.0e+00 | -1.60e-01 | 6.3e-01 | -1.10e-01 | 5.9e-01 |
| 231 | Pik3c2a | 5.00e-02 | 9.1e-01 | -4.00e-02 | 9.6e-01 | -5.00e-01 | 3.5e-01 | -1.90e-01 | 7.7e-01 | 7.10e-01 | 1.0e-02 | -1.00e-01 | 7.5e-01 |
| 159 | Hsd17b2 | -7.50e-01 | 2.0e-02 | -1.00e-02 | NA | -8.00e-02 | 9.1e-01 | -1.70e+00 | 0.0e+00 | NA | NA | -9.00e-02 | NA |
| 213 | Nr1h4 | -1.50e-01 | 8.0e-01 | 0.00e+00 | NA | -7.90e-01 | 4.0e-02 | -1.00e-01 | 6.1e-01 | 1.00e-02 | NA | -9.00e-02 | NA |
| 321 | Sqle | -5.00e-02 | 7.3e-01 | 2.10e-01 | 3.3e-01 | 1.70e-01 | 5.8e-01 | 7.90e-01 | 3.0e-02 | 6.60e-01 | 4.0e-02 | -6.00e-02 | 8.7e-01 |
| 43 | Amacr | 5.00e-02 | 8.3e-01 | 1.30e-01 | 7.1e-01 | -2.70e-01 | 5.4e-01 | -1.44e+00 | 0.0e+00 | -3.00e-02 | 9.4e-01 | -6.00e-02 | 8.0e-01 |
| 155 | Hrasls | -9.60e-01 | 0.0e+00 | -1.40e-01 | 5.8e-01 | -1.20e+00 | 0.0e+00 | -4.90e-01 | 4.3e-01 | -7.10e-01 | 1.7e-01 | -6.00e-02 | 7.4e-01 |
| 344 | Ube2i | 5.00e-02 | 9.4e-01 | -9.00e-02 | NA | 9.10e-01 | 9.0e-02 | 1.80e-01 | NA | -5.00e-01 | 3.8e-01 | -5.00e-02 | 9.5e-01 |
| 5 | Abcd1 | -4.40e-01 | 0.0e+00 | -2.60e-01 | 2.3e-01 | -6.00e-01 | 0.0e+00 | -1.60e-01 | 6.3e-01 | -3.20e-01 | 1.7e-01 | -5.00e-02 | 8.3e-01 |
| 74 | Cpt1b | -7.00e-01 | 6.0e-02 | -2.30e-01 | 6.0e-01 | 5.80e-01 | 2.0e-01 | 4.90e-01 | 1.5e-01 | -2.00e-01 | 5.5e-01 | -4.00e-02 | 8.8e-01 |
| 78 | Csnk2a2 | 4.80e-01 | 0.0e+00 | 1.60e-01 | 5.1e-01 | 7.90e-01 | 0.0e+00 | 2.80e-01 | 1.3e-01 | 5.00e-02 | 9.3e-01 | -4.00e-02 | 8.5e-01 |
| 343 | Txnrd1 | 6.60e-01 | 0.0e+00 | 1.10e-01 | 7.3e-01 | 7.50e-01 | 0.0e+00 | -2.30e-01 | 1.8e-01 | 1.10e-01 | 6.9e-01 | -4.00e-02 | 8.3e-01 |
| 331 | Synj2 | -3.10e-01 | 4.0e-02 | 5.90e-01 | 1.0e-02 | -3.40e-01 | 1.8e-01 | -3.60e-01 | 3.9e-01 | -3.60e-01 | 4.6e-01 | -3.00e-02 | 9.4e-01 |
| 272 | Pon1 | -7.60e-01 | 6.0e-02 | 1.00e-02 | 9.9e-01 | -7.70e-01 | 1.9e-01 | -1.20e-01 | 5.6e-01 | -5.00e-02 | 9.6e-01 | -2.00e-02 | NA |
| 152 | Helz2 | -5.00e-01 | 0.0e+00 | -6.00e-01 | 1.0e-02 | -1.28e+00 | 0.0e+00 | -1.35e+00 | 0.0e+00 | -1.80e-01 | 5.8e-01 | -1.00e-02 | 9.8e-01 |
| 99 | Ehhadh | 2.20e-01 | 4.4e-01 | 1.02e+00 | 0.0e+00 | -5.90e-01 | 1.0e-01 | 6.00e-02 | 9.1e-01 | 9.00e-02 | 8.6e-01 | -1.00e-02 | 9.9e-01 |
| 13 | Acbd5 | -3.00e-01 | 8.0e-02 | -2.10e-01 | 5.0e-01 | -6.90e-01 | 4.0e-02 | -2.70e-01 | 4.2e-01 | -9.00e-02 | 8.5e-01 | -1.00e-02 | 9.9e-01 |
| 271 | Pnpla8 | 1.00e-01 | 7.6e-01 | -7.00e-02 | 9.0e-01 | 1.70e-01 | 7.4e-01 | 3.30e-01 | 3.2e-01 | 8.80e-01 | 0.0e+00 | 0.00e+00 | 9.9e-01 |
| 253 | Pla2g4b | -6.00e-02 | 7.7e-01 | -3.00e-02 | 9.7e-01 | -6.60e-01 | 0.0e+00 | 1.40e-01 | 7.0e-01 | -4.90e-01 | 5.0e-02 | 2.00e-02 | 9.6e-01 |
| 340 | Tnfrsf21 | 1.04e+00 | 0.0e+00 | 1.00e-01 | 5.7e-01 | 1.01e+00 | 0.0e+00 | 0.00e+00 | 1.0e+00 | -2.20e-01 | 5.2e-01 | 2.00e-02 | 9.3e-01 |
| 168 | Insig1 | 4.60e-01 | 0.0e+00 | 7.30e-01 | 0.0e+00 | 5.10e-01 | 1.0e-02 | 1.89e+00 | 0.0e+00 | 5.20e-01 | 1.6e-01 | 5.00e-02 | 8.5e-01 |
| 69 | Col4a3bp | -1.20e-01 | 6.0e-01 | -1.20e-01 | 7.9e-01 | -8.20e-01 | 0.0e+00 | -3.00e-02 | 9.7e-01 | -3.10e-01 | 3.9e-01 | 5.00e-02 | 8.0e-01 |
| 243 | Pisd | 3.10e-01 | 0.0e+00 | 8.00e-02 | 8.2e-01 | -1.10e-01 | 3.8e-01 | 3.40e-01 | 1.0e-02 | 1.50e+00 | 0.0e+00 | 5.00e-02 | 8.1e-01 |
| 140 | Gpat2 | 6.90e-01 | 8.0e-02 | -1.60e-01 | NA | 2.60e-01 | 7.3e-01 | -4.00e-02 | 9.8e-01 | 2.00e-02 | NA | 6.00e-02 | NA |
| 17 | Acot1 | 1.35e+00 | 0.0e+00 | 3.00e-01 | 4.6e-01 | -2.30e-01 | 6.4e-01 | 1.88e+00 | 0.0e+00 | 2.60e-01 | NA | 6.00e-02 | 9.4e-01 |
| 198 | Mtmr14 | 1.00e-01 | 7.6e-01 | 4.00e-02 | 9.4e-01 | -6.20e-01 | 5.0e-02 | 9.00e-02 | 7.8e-01 | -2.40e-01 | 2.5e-01 | 7.00e-02 | 7.7e-01 |
| 172 | Liph | 3.60e-01 | 4.0e-02 | 1.00e-02 | NA | 1.22e+00 | 3.0e-02 | -5.00e-02 | NA | 2.40e-01 | NA | 9.00e-02 | NA |
| 63 | Cers3 | 1.40e-01 | 8.1e-01 | 5.00e-02 | NA | 1.30e-01 | NA | -1.00e+00 | 3.0e-02 | -4.00e-02 | NA | 9.00e-02 | NA |
| 284 | Prkag2 | -1.60e-01 | 3.1e-01 | -2.00e-01 | 4.5e-01 | -4.20e-01 | 3.0e-02 | -6.40e-01 | 0.0e+00 | -4.50e-01 | 1.0e-02 | 1.00e-01 | 6.4e-01 |
| 95 | Dhcr24 | 5.00e-02 | 8.3e-01 | 2.00e-02 | 9.6e-01 | -3.90e-01 | 1.0e-02 | 1.05e+00 | 0.0e+00 | 1.30e-01 | 8.5e-01 | 1.10e-01 | 6.2e-01 |
| 200 | Mtmr9 | -1.10e-01 | 6.0e-01 | -2.00e-02 | 9.8e-01 | -5.90e-01 | 1.0e-02 | 1.10e-01 | 7.9e-01 | 6.00e-02 | 9.1e-01 | 1.10e-01 | 6.4e-01 |
| 55 | Baat | -6.40e-01 | 3.0e-02 | -1.00e-01 | 8.7e-01 | -5.60e-01 | 3.7e-01 | -1.32e+00 | 0.0e+00 | -2.80e-01 | NA | 1.10e-01 | NA |
| 73 | Cpt1a | 6.60e-01 | 0.0e+00 | 6.00e-02 | 8.8e-01 | -1.20e-01 | 7.8e-01 | 7.80e-01 | 1.0e-02 | 1.60e-01 | 5.3e-01 | 1.20e-01 | 6.3e-01 |
| 44 | Angptl4 | 4.90e-01 | 2.1e-01 | 2.40e-01 | 5.6e-01 | 7.80e-01 | 0.0e+00 | 3.00e-01 | 1.4e-01 | 1.10e-01 | 8.1e-01 | 1.20e-01 | 7.7e-01 |
| 170 | Kdsr | 5.00e-01 | 0.0e+00 | 7.00e-02 | 8.2e-01 | -6.50e-01 | 0.0e+00 | 4.50e-01 | 0.0e+00 | 2.00e-02 | 9.5e-01 | 1.30e-01 | 5.7e-01 |
| 190 | Med31 | -4.70e-01 | 1.0e-02 | 8.00e-02 | 8.2e-01 | -7.00e-01 | 0.0e+00 | -4.50e-01 | 2.0e-01 | -2.50e-01 | 5.2e-01 | 1.30e-01 | 7.3e-01 |
| 221 | Osbpl9 | 3.00e-02 | 8.8e-01 | -6.00e-02 | 8.5e-01 | -6.40e-01 | 0.0e+00 | -2.20e-01 | 3.7e-01 | -8.00e-02 | 7.7e-01 | 1.50e-01 | 1.7e-01 |
| 180 | Lta4h | -1.20e-01 | 4.8e-01 | -4.00e-02 | 9.2e-01 | -8.60e-01 | 0.0e+00 | -4.60e-01 | 0.0e+00 | -3.00e-01 | 1.4e-01 | 1.60e-01 | 3.7e-01 |
| 229 | Pi4k2a | 1.80e-01 | 2.5e-01 | 0.00e+00 | 1.0e+00 | 4.30e-01 | 6.0e-02 | 4.60e-01 | 1.0e-02 | 6.00e-01 | 1.0e-02 | 1.70e-01 | 4.3e-01 |
| 275 | Ppara | -6.80e-01 | 1.0e-02 | 9.00e-02 | 8.8e-01 | -3.60e-01 | 2.6e-01 | 4.40e-01 | 4.4e-01 | 6.00e-02 | 9.3e-01 | 1.80e-01 | 5.7e-01 |
| 212 | Nr1h3 | -4.50e-01 | 1.0e-02 | 2.00e-02 | 9.8e-01 | -9.40e-01 | 0.0e+00 | -5.10e-01 | 0.0e+00 | -3.80e-01 | 1.4e-01 | 1.90e-01 | 4.1e-01 |
| 61 | Cdk19 | 6.00e-02 | 8.4e-01 | -1.60e-01 | 5.0e-01 | -8.90e-01 | 0.0e+00 | 9.60e-01 | 0.0e+00 | -2.70e-01 | 3.5e-01 | 2.00e-01 | 3.6e-01 |
| 87 | Cyp46a1 | 7.90e-01 | 0.0e+00 | 1.40e-01 | 7.3e-01 | -4.00e-01 | 3.7e-01 | 5.20e-01 | 4.0e-01 | -2.20e-01 | 7.3e-01 | 2.20e-01 | 7.6e-01 |
| 238 | Pik3r4 | -4.00e-02 | 8.4e-01 | -5.00e-02 | 8.9e-01 | -7.30e-01 | 0.0e+00 | -1.00e-01 | 6.2e-01 | -2.50e-01 | 7.0e-02 | 2.20e-01 | 1.3e-01 |
| 109 | Etnppl | -2.80e-01 | 5.3e-01 | 2.20e-01 | 3.8e-01 | -4.90e-01 | 4.5e-01 | 2.36e+00 | 0.0e+00 | 7.00e-02 | NA | 2.30e-01 | 7.5e-01 |
| 36 | Akr1b1 | -9.00e-02 | 6.5e-01 | 1.20e-01 | 7.9e-01 | 1.99e+00 | 0.0e+00 | -2.50e-01 | 5.7e-01 | 3.10e-01 | 2.9e-01 | 2.40e-01 | 3.2e-01 |
| 211 | Nr1d1 | 1.10e-01 | 7.3e-01 | 5.00e-02 | 9.2e-01 | 6.60e-01 | 0.0e+00 | -4.50e-01 | 2.5e-01 | -5.90e-01 | 2.0e-02 | 2.60e-01 | 1.9e-01 |
| 287 | Ptdss2 | -6.00e-02 | 7.1e-01 | 1.20e-01 | 5.5e-01 | -2.30e-01 | 2.2e-01 | 7.90e-01 | 0.0e+00 | 1.40e-01 | 5.1e-01 | 2.60e-01 | 7.0e-02 |
| 314 | Smpd1 | 1.00e-02 | 9.8e-01 | 1.30e-01 | 6.5e-01 | -8.40e-01 | 0.0e+00 | -1.00e-02 | 9.9e-01 | -9.00e-02 | 7.8e-01 | 2.80e-01 | 3.0e-02 |
| 308 | Slc25a17 | 3.50e-01 | 0.0e+00 | 2.60e-01 | 4.0e-02 | 1.00e+00 | 0.0e+00 | 4.10e-01 | 3.0e-02 | 3.30e-01 | 1.0e-02 | 2.90e-01 | 4.0e-02 |
| 178 | Lrp2 | -2.30e-01 | 1.8e-01 | -1.00e-02 | 9.8e-01 | 7.40e-01 | 9.0e-02 | -5.90e-01 | 7.0e-02 | -2.00e-02 | 9.9e-01 | 2.90e-01 | 7.2e-01 |
| 283 | Prkacb | 1.10e-01 | 6.6e-01 | -5.00e-02 | 9.2e-01 | 9.30e-01 | 0.0e+00 | 1.90e-01 | 7.9e-01 | 2.30e-01 | 5.8e-01 | 3.00e-01 | 7.0e-02 |
| 85 | Cyp2r1 | -6.60e-01 | 8.0e-02 | -2.80e-01 | 5.8e-01 | -4.70e-01 | 4.7e-01 | -4.00e-01 | 2.0e-01 | -4.20e-01 | 4.9e-01 | 3.10e-01 | 7.0e-01 |
| 128 | Fig4 | -1.20e-01 | 4.5e-01 | 8.00e-02 | 8.7e-01 | -6.40e-01 | 0.0e+00 | -2.30e-01 | 1.0e-01 | -1.80e-01 | 4.1e-01 | 3.20e-01 | 1.0e-02 |
| 184 | Mcat | -1.70e-01 | 5.0e-01 | -3.00e-02 | 9.5e-01 | -2.30e-01 | 4.0e-01 | -2.10e-01 | 4.9e-01 | -6.00e-01 | 0.0e+00 | 3.30e-01 | 3.0e-02 |
| 278 | Ppargc1a | -1.80e-01 | 6.5e-01 | -1.30e-01 | 8.4e-01 | 2.00e-01 | 7.5e-01 | 2.46e+00 | 0.0e+00 | -8.00e-02 | 9.2e-01 | 3.30e-01 | 1.6e-01 |
| 224 | Pcyt1a | 2.90e-01 | 2.0e-02 | -2.00e-02 | 9.6e-01 | 5.20e-01 | 0.0e+00 | 1.25e+00 | 0.0e+00 | 6.90e-01 | 0.0e+00 | 3.40e-01 | 0.0e+00 |
| 94 | Dgat1 | 9.00e-02 | 8.2e-01 | -5.00e-02 | 9.3e-01 | 2.10e+00 | 0.0e+00 | 3.30e-01 | 2.1e-01 | 1.60e-01 | 5.4e-01 | 3.40e-01 | 4.0e-02 |
| 347 | Vapa | 5.40e-01 | 0.0e+00 | 2.50e-01 | 5.0e-02 | 6.00e-01 | 0.0e+00 | 4.80e-01 | 0.0e+00 | 1.02e+00 | 0.0e+00 | 3.60e-01 | 2.2e-01 |
| 92 | Dbi | -2.90e-01 | 2.9e-01 | 6.40e-01 | 0.0e+00 | -4.80e-01 | 3.0e-02 | -3.00e-02 | 9.7e-01 | 4.20e-01 | 2.3e-01 | 3.60e-01 | 2.4e-01 |
| 58 | Bmx | 1.38e+00 | 0.0e+00 | 1.80e-01 | 7.5e-01 | -7.00e-02 | NA | 4.20e-01 | NA | -2.20e-01 | 7.2e-01 | 3.80e-01 | 5.1e-01 |
| 203 | Ncoa2 | -2.70e-01 | 4.3e-01 | -1.40e-01 | 8.3e-01 | -6.40e-01 | 4.0e-02 | -3.10e-01 | 6.2e-01 | -2.80e-01 | 4.5e-01 | 3.80e-01 | 3.0e-01 |
| 186 | Med12 | -3.10e-01 | 1.3e-01 | -3.60e-01 | 1.0e-01 | -6.00e-01 | 0.0e+00 | -9.00e-02 | 8.9e-01 | -1.70e-01 | 5.1e-01 | 3.80e-01 | 1.7e-01 |
| 88 | Cyp4a2 | -6.70e-01 | 3.0e-02 | -5.00e-02 | 9.2e-01 | -8.20e-01 | 1.5e-01 | 1.60e-01 | 6.2e-01 | -5.00e-02 | NA | 4.00e-01 | NA |
| 124 | Fdps | 3.90e-01 | 1.0e-02 | 1.80e-01 | 5.5e-01 | 7.00e-02 | 8.6e-01 | 1.20e-01 | 8.6e-01 | 6.20e-01 | 0.0e+00 | 4.10e-01 | 8.0e-02 |
| 302 | Sgms1 | 9.70e-01 | 0.0e+00 | 4.00e-02 | 9.2e-01 | -2.80e-01 | 1.9e-01 | 1.79e+00 | 0.0e+00 | 1.63e+00 | 0.0e+00 | 4.20e-01 | 6.0e-02 |
| 181 | Mapkapk2 | 3.80e-01 | 1.0e-02 | 1.80e-01 | 5.6e-01 | 8.70e-01 | 0.0e+00 | 5.10e-01 | 1.0e-02 | 1.70e-01 | 4.2e-01 | 4.50e-01 | 0.0e+00 |
| 306 | Sgpp2 | -1.07e+00 | 0.0e+00 | -3.80e-01 | 2.2e-01 | -3.10e-01 | 2.7e-01 | -2.00e-01 | 8.4e-01 | -1.30e-01 | 8.8e-01 | 4.70e-01 | 5.5e-01 |
| 147 | Gstm4 | 5.60e-01 | 0.0e+00 | 1.30e-01 | 7.8e-01 | 1.00e-02 | 9.7e-01 | 8.00e-01 | 0.0e+00 | 1.10e-01 | 6.5e-01 | 4.90e-01 | 0.0e+00 |
| 295 | Rxrb | -2.00e-02 | 9.3e-01 | 2.00e-02 | 9.7e-01 | -3.80e-01 | 2.7e-01 | -1.10e-01 | 8.1e-01 | -6.10e-01 | 1.0e-02 | 5.00e-01 | 1.0e-02 |
| 307 | Slc10a1 | -6.90e-01 | 4.0e-02 | -1.00e-02 | 9.9e-01 | -5.80e-01 | 3.6e-01 | -8.00e-02 | 8.8e-01 | 4.00e-01 | 5.2e-01 | 5.00e-01 | 4.2e-01 |
| 255 | Pla2g4f | 6.50e-01 | 1.0e-01 | -2.40e-01 | 6.5e-01 | 2.21e+00 | 0.0e+00 | 5.50e-01 | NA | -4.00e-02 | 9.6e-01 | 5.00e-01 | 4.5e-01 |
| 280 | Ppt2 | -1.40e-01 | 3.1e-01 | -2.60e-01 | 2.3e-01 | -3.80e-01 | 0.0e+00 | -6.00e-02 | 8.7e-01 | -6.30e-01 | 0.0e+00 | 5.00e-01 | 1.0e-02 |
| 219 | Osbpl6 | -8.00e-01 | 0.0e+00 | -2.30e-01 | 3.9e-01 | 5.00e-02 | 9.1e-01 | -4.30e-01 | 5.3e-01 | -4.10e-01 | 1.8e-01 | 5.00e-01 | 2.0e-02 |
| 188 | Med13l | 5.50e-01 | 0.0e+00 | -3.00e-02 | 9.6e-01 | 4.20e-01 | 1.1e-01 | 3.00e-01 | 5.2e-01 | 7.10e-01 | 0.0e+00 | 5.00e-01 | 0.0e+00 |
| 293 | Rora | 1.70e-01 | 7.4e-01 | 2.00e-02 | 9.9e-01 | 1.67e+00 | 0.0e+00 | 4.80e-01 | 3.5e-01 | 9.00e-01 | 1.0e-02 | 5.00e-01 | 9.0e-02 |
| 199 | Mtmr7 | 3.00e-02 | 9.5e-01 | -6.00e-02 | 9.0e-01 | -2.70e-01 | 5.4e-01 | 1.94e+00 | 0.0e+00 | -1.70e-01 | 8.3e-01 | 5.10e-01 | 2.2e-01 |
| 12 | Acat2 | -2.70e-01 | 3.1e-01 | 2.40e-01 | 4.8e-01 | 6.00e-01 | 1.0e-02 | 4.00e-02 | 9.6e-01 | -1.30e-01 | 7.9e-01 | 5.20e-01 | 2.2e-01 |
| 228 | Phospho1 | -7.40e-01 | 0.0e+00 | -1.60e-01 | 6.8e-01 | 1.00e-02 | 9.9e-01 | -1.00e-01 | 8.6e-01 | 6.00e-02 | 9.1e-01 | 5.20e-01 | 1.0e-02 |
| 125 | Fdx1 | 5.10e-01 | 1.0e-02 | 8.00e-02 | 9.2e-01 | 6.80e-01 | 1.0e-02 | 5.00e-02 | 9.5e-01 | 1.70e-01 | 4.3e-01 | 5.50e-01 | 0.0e+00 |
| 161 | Hsd17b7 | 2.00e-02 | 9.4e-01 | 2.90e-01 | 2.2e-01 | -8.80e-01 | 0.0e+00 | 4.60e-01 | 1.0e-01 | 2.70e-01 | 5.3e-01 | 5.60e-01 | 3.0e-02 |
| 77 | Crat | 9.00e-02 | 7.3e-01 | 1.70e-01 | 3.8e-01 | 7.00e-02 | 8.2e-01 | 1.59e+00 | 0.0e+00 | -6.00e-02 | 8.7e-01 | 5.80e-01 | 0.0e+00 |
| 133 | Gde1 | 1.90e-01 | 2.0e-01 | 1.50e-01 | 6.0e-01 | 9.70e-01 | 0.0e+00 | 1.40e-01 | 6.5e-01 | 1.10e-01 | 8.0e-01 | 5.80e-01 | 0.0e+00 |
| 8 | Acacb | -3.30e-01 | 2.0e-02 | -7.00e-02 | 8.6e-01 | 2.00e-01 | 7.5e-01 | -2.30e-01 | 6.4e-01 | -6.80e-01 | 1.0e-02 | 5.80e-01 | 0.0e+00 |
| 274 | Pon3 | -3.00e-01 | 8.0e-02 | -1.70e-01 | 7.9e-01 | -1.00e-02 | 9.9e-01 | -2.00e-01 | 3.7e-01 | 3.20e-01 | 2.8e-01 | 5.90e-01 | 2.0e-02 |
| 31 | Agpat1 | -3.60e-01 | 4.0e-02 | 6.00e-02 | 8.9e-01 | -1.00e-02 | 9.9e-01 | 1.00e-02 | 9.9e-01 | -3.10e-01 | 2.4e-01 | 6.00e-01 | 0.0e+00 |
| 26 | Acsl3 | 5.00e-02 | 7.9e-01 | 5.10e-01 | 0.0e+00 | -6.20e-01 | 0.0e+00 | -2.50e-01 | 4.6e-01 | -2.00e-01 | 6.0e-01 | 6.10e-01 | 0.0e+00 |
| 66 | Chka | 4.90e-01 | 0.0e+00 | 4.00e-02 | 9.3e-01 | -2.00e-02 | 9.7e-01 | -1.51e+00 | 0.0e+00 | 5.00e-02 | 9.5e-01 | 6.10e-01 | 1.0e-02 |
| 80 | Cubn | 1.64e+00 | 0.0e+00 | -3.40e-01 | 4.4e-01 | 5.90e-01 | 3.1e-01 | 5.30e-01 | NA | 4.90e-01 | 1.3e-01 | 6.30e-01 | 1.7e-01 |
| 14 | Acer2 | 1.49e+00 | 0.0e+00 | 8.20e-01 | 0.0e+00 | 5.50e-01 | 0.0e+00 | 8.00e-01 | 3.0e-02 | 4.50e-01 | 1.0e-01 | 6.40e-01 | 0.0e+00 |
| 281 | Prkaa2 | -3.80e-01 | 3.1e-01 | -2.10e-01 | 7.2e-01 | -5.30e-01 | 2.3e-01 | 2.30e-01 | 8.0e-01 | 9.00e-02 | 9.2e-01 | 6.40e-01 | 3.0e-02 |
| 207 | Neu2 | -3.00e-01 | 5.5e-01 | 3.00e-01 | 5.4e-01 | 5.70e-01 | 3.8e-01 | 2.00e-02 | 9.9e-01 | -4.30e-01 | 3.1e-01 | 6.60e-01 | 0.0e+00 |
| 197 | Mtmr1 | 1.10e-01 | 3.7e-01 | 7.00e-02 | 8.1e-01 | -1.00e-01 | 7.9e-01 | -2.00e-01 | 2.4e-01 | -1.40e-01 | 6.4e-01 | 6.60e-01 | 0.0e+00 |
| 79 | Csnk2b | 2.70e-01 | 2.3e-01 | 2.80e-01 | 4.2e-01 | 3.20e-01 | 3.9e-01 | 9.00e-02 | 8.8e-01 | 1.40e-01 | 6.2e-01 | 6.60e-01 | 0.0e+00 |
| 191 | Med4 | 3.20e-01 | 8.0e-02 | 1.20e-01 | 8.0e-01 | 3.20e-01 | 2.9e-01 | 6.00e-02 | 9.5e-01 | 4.00e-01 | 1.9e-01 | 6.60e-01 | 0.0e+00 |
| 206 | Neu1 | 4.00e-01 | 3.0e-02 | 2.70e-01 | 4.5e-01 | 4.20e-01 | 1.6e-01 | -1.00e-01 | 8.5e-01 | 2.80e-01 | 4.8e-01 | 6.70e-01 | 1.0e-02 |
| 214 | Ocrl | -5.10e-01 | 1.0e-02 | -3.00e-02 | 9.7e-01 | -1.48e+00 | 0.0e+00 | -1.90e-01 | 7.5e-01 | -8.00e-02 | 8.8e-01 | 6.70e-01 | 1.0e-02 |
| 247 | Pla1a | 6.00e-01 | 0.0e+00 | 3.40e-01 | 4.5e-01 | 6.50e-01 | 0.0e+00 | 3.20e-01 | 3.1e-01 | 2.70e-01 | 4.5e-01 | 6.80e-01 | 0.0e+00 |
| 52 | Asah2 | -2.80e-01 | 7.0e-02 | -9.00e-02 | 8.6e-01 | -3.00e-01 | 2.0e-01 | -1.00e-02 | 9.9e-01 | -1.00e-01 | 8.7e-01 | 6.80e-01 | 0.0e+00 |
| 162 | Hsd17b8 | 1.00e-02 | 9.8e-01 | 2.50e-01 | 4.8e-01 | 2.00e-02 | 9.6e-01 | 3.00e-02 | 9.8e-01 | -1.00e-02 | 9.9e-01 | 7.00e-01 | 0.0e+00 |
| 120 | Far2 | 1.81e+00 | 0.0e+00 | -1.40e-01 | 7.3e-01 | -1.70e-01 | 4.7e-01 | 3.00e-01 | 7.0e-01 | -3.00e-02 | 9.8e-01 | 7.00e-01 | 1.4e-01 |
| 268 | Pnpla2 | 1.01e+00 | 0.0e+00 | 1.24e+00 | 0.0e+00 | 6.00e-01 | 4.0e-02 | 2.09e+00 | 0.0e+00 | 4.00e-02 | 9.4e-01 | 7.10e-01 | 0.0e+00 |
| 11 | Acads | 9.00e-02 | 8.2e-01 | 1.70e-01 | 7.0e-01 | -1.10e-01 | 8.3e-01 | 9.00e-02 | 8.8e-01 | -7.00e-02 | 9.0e-01 | 7.10e-01 | 0.0e+00 |
| 142 | Gpcpd1 | 1.80e-01 | 3.5e-01 | 2.20e-01 | 4.3e-01 | -1.06e+00 | 0.0e+00 | 3.90e-01 | 2.0e-01 | 8.10e-01 | 0.0e+00 | 7.20e-01 | 0.0e+00 |
| 185 | Med11 | -1.80e-01 | 6.7e-01 | 1.60e-01 | 7.9e-01 | -2.70e-01 | 6.5e-01 | -1.00e-02 | 9.9e-01 | -2.00e-02 | 9.9e-01 | 7.30e-01 | 7.0e-02 |
| 241 | Pip4k2b | -2.50e-01 | 1.1e-01 | 4.00e-02 | 9.4e-01 | -4.90e-01 | 5.0e-02 | -3.30e-01 | 2.6e-01 | -5.40e-01 | 1.0e-02 | 7.40e-01 | 0.0e+00 |
| 177 | Lpin3 | 1.00e-01 | 4.6e-01 | 1.40e-01 | 7.0e-01 | -2.80e-01 | 4.4e-01 | 3.50e-01 | 1.7e-01 | -8.00e-02 | 8.8e-01 | 7.40e-01 | 0.0e+00 |
| 299 | Sec23a | -3.80e-01 | 3.0e-02 | -4.00e-02 | 9.5e-01 | -8.00e-02 | 7.5e-01 | 4.20e-01 | 1.3e-01 | -6.00e-02 | 9.1e-01 | 7.60e-01 | 0.0e+00 |
| 105 | Esrra | 1.10e-01 | 7.7e-01 | -1.80e-01 | 7.2e-01 | 1.60e-01 | 7.7e-01 | 7.50e-01 | 3.0e-02 | -2.00e-02 | 9.6e-01 | 7.60e-01 | 0.0e+00 |
| 269 | Pnpla3 | -9.50e-01 | 1.0e-02 | -2.40e-01 | 3.9e-01 | -2.60e-01 | 6.6e-01 | 3.70e-01 | 6.1e-01 | -3.50e-01 | 5.4e-01 | 7.70e-01 | 3.0e-02 |
| 93 | Ddhd1 | -3.00e-02 | 9.2e-01 | 6.00e-02 | 8.9e-01 | -5.20e-01 | 1.0e-02 | -1.80e-01 | 7.3e-01 | 6.20e-01 | 3.0e-02 | 7.70e-01 | 0.0e+00 |
| 189 | Med26 | 3.00e-01 | 1.7e-01 | 1.50e-01 | 6.2e-01 | 6.90e-01 | 0.0e+00 | 2.40e-01 | 4.9e-01 | 1.20e-01 | 7.4e-01 | 7.80e-01 | 0.0e+00 |
| 129 | Fitm1 | -3.00e-02 | 9.6e-01 | 2.00e-02 | NA | 8.90e-01 | 1.0e-01 | 3.00e-02 | NA | -6.70e-01 | 1.2e-01 | 7.80e-01 | 0.0e+00 |
| 179 | Lss | -1.10e-01 | 3.5e-01 | -3.00e-02 | 9.2e-01 | -9.90e-01 | 0.0e+00 | -2.10e-01 | 5.8e-01 | 8.00e-02 | 8.4e-01 | 8.00e-01 | 0.0e+00 |
| 1 | Aacs | -2.30e-01 | 2.1e-01 | 2.50e-01 | 2.2e-01 | -1.70e-01 | 6.5e-01 | -8.80e-01 | 2.0e-02 | 1.52e+00 | 0.0e+00 | 8.10e-01 | 0.0e+00 |
| 205 | Ndufab1 | -9.00e-02 | 7.2e-01 | 3.80e-01 | 1.7e-01 | 4.00e-02 | 9.3e-01 | 9.00e-02 | 9.2e-01 | 4.00e-02 | 9.5e-01 | 8.40e-01 | 0.0e+00 |
| 323 | Srebf1 | 1.10e-01 | 7.2e-01 | 3.30e-01 | 2.0e-02 | -6.60e-01 | 0.0e+00 | -1.50e-01 | 7.7e-01 | -1.01e+00 | 0.0e+00 | 8.40e-01 | 0.0e+00 |
| 204 | Ncor2 | 4.00e-02 | 7.6e-01 | -5.00e-02 | 9.0e-01 | -1.80e-01 | 2.7e-01 | 5.80e-01 | 0.0e+00 | 3.70e-01 | 1.3e-01 | 8.50e-01 | 0.0e+00 |
| 57 | Bdh2 | -3.00e-02 | 9.5e-01 | 4.00e-02 | 9.7e-01 | -1.50e-01 | 8.3e-01 | -3.10e-01 | 5.6e-01 | 2.10e-01 | 6.0e-01 | 8.60e-01 | 3.0e-02 |
| 325 | Stard10 | 9.00e-02 | 7.3e-01 | 2.10e-01 | 6.0e-01 | -5.00e-02 | 9.1e-01 | -3.00e-02 | 9.7e-01 | -2.20e-01 | 7.6e-01 | 8.70e-01 | 0.0e+00 |
| 329 | Sumo2 | 3.00e-02 | 9.1e-01 | 1.60e-01 | 7.0e-01 | 9.00e-02 | 6.6e-01 | -1.00e-02 | 9.9e-01 | 3.00e-02 | 9.7e-01 | 8.80e-01 | 0.0e+00 |
| 145 | Gpd2 | -3.10e-01 | 6.0e-02 | -3.00e-01 | 6.0e-02 | -1.20e-01 | 6.6e-01 | -9.00e-02 | 8.8e-01 | -4.10e-01 | 3.2e-01 | 8.80e-01 | 0.0e+00 |
| 294 | Rxra | 4.00e-02 | 7.9e-01 | 7.00e-02 | 8.8e-01 | -1.10e-01 | 7.6e-01 | 3.90e-01 | 4.0e-02 | 7.00e-02 | 8.5e-01 | 8.90e-01 | 0.0e+00 |
| 62 | Cds1 | 1.70e-01 | 4.3e-01 | -2.00e-02 | 9.7e-01 | 2.00e-01 | 6.1e-01 | -2.00e-02 | 9.8e-01 | -7.00e-02 | 8.9e-01 | 8.90e-01 | 1.0e-01 |
| 201 | Mvd | -3.10e-01 | 4.4e-01 | 2.90e-01 | 3.6e-01 | -8.00e-02 | 8.8e-01 | -5.50e-01 | 1.8e-01 | 9.00e-02 | 8.8e-01 | 9.00e-01 | 2.0e-02 |
| 112 | Fabp1 | -5.00e-01 | 1.0e-01 | 2.00e-02 | 9.7e-01 | -2.60e-01 | 6.9e-01 | -2.00e-01 | 7.5e-01 | -2.10e-01 | NA | 9.30e-01 | 2.0e-02 |
| 282 | Prkab2 | -6.00e-02 | 7.7e-01 | 8.00e-02 | 8.3e-01 | -3.70e-01 | 4.0e-02 | -1.00e-01 | 8.7e-01 | -3.60e-01 | 3.7e-01 | 9.30e-01 | 0.0e+00 |
| 146 | Grhl1 | 6.40e-01 | 0.0e+00 | -1.00e-02 | 9.9e-01 | 4.60e-01 | 1.3e-01 | 7.60e-01 | 1.5e-01 | 4.40e-01 | 3.7e-01 | 9.50e-01 | 3.0e-02 |
| 324 | Star | 3.10e-01 | 5.3e-01 | 4.00e-02 | 9.4e-01 | 5.60e-01 | 5.0e-02 | 4.00e-02 | 9.8e-01 | -6.40e-01 | 1.0e-02 | 9.50e-01 | 8.0e-02 |
| 9 | Acad11 | -2.00e-02 | 9.3e-01 | -4.00e-02 | 9.4e-01 | -3.60e-01 | 1.6e-01 | 1.00e-02 | 9.9e-01 | 1.00e-01 | 8.2e-01 | 9.60e-01 | 0.0e+00 |
| 46 | Arf1 | 2.90e-01 | 1.4e-01 | 3.20e-01 | 1.7e-01 | 3.50e-01 | 2.9e-01 | 2.00e-01 | 5.9e-01 | 1.90e-01 | 6.3e-01 | 9.70e-01 | 0.0e+00 |
| 225 | Pecr | 7.00e-01 | 0.0e+00 | 2.20e-01 | 5.0e-01 | -2.70e-01 | 5.3e-01 | -5.00e-02 | 9.4e-01 | 1.00e-01 | 8.4e-01 | 9.90e-01 | 0.0e+00 |
| 202 | Mvk | 2.10e-01 | 6.3e-01 | 3.10e-01 | 3.9e-01 | -2.40e-01 | 6.5e-01 | -9.00e-02 | 9.3e-01 | -4.00e-02 | 9.5e-01 | 1.05e+00 | 0.0e+00 |
| 223 | Pctp | 7.50e-01 | 0.0e+00 | 8.00e-02 | 9.0e-01 | -4.40e-01 | 0.0e+00 | 2.80e-01 | 4.2e-01 | 3.00e-01 | 4.5e-01 | 1.06e+00 | 0.0e+00 |
| 335 | Tiam2 | -3.80e-01 | 1.0e-02 | 7.00e-02 | 8.6e-01 | 9.50e-01 | 0.0e+00 | 3.30e-01 | 5.2e-01 | 1.40e-01 | 7.5e-01 | 1.07e+00 | 0.0e+00 |
| 317 | Spns2 | -6.90e-01 | 0.0e+00 | 2.70e-01 | 8.0e-02 | 5.10e-01 | 7.0e-02 | -9.00e-02 | 9.3e-01 | -8.00e-02 | 8.9e-01 | 1.07e+00 | 0.0e+00 |
| 328 | Sumf2 | -2.10e-01 | 3.5e-01 | 1.40e-01 | 7.3e-01 | -1.30e-01 | 6.4e-01 | -1.00e-02 | 9.9e-01 | -1.30e-01 | 7.2e-01 | 1.10e+00 | 0.0e+00 |
| 276 | Ppard | 4.70e-01 | 0.0e+00 | 4.70e-01 | 1.0e-02 | -8.00e-02 | 8.5e-01 | 8.50e-01 | 0.0e+00 | 7.40e-01 | 0.0e+00 | 1.15e+00 | 0.0e+00 |
| 297 | Sar1b | 1.80e-01 | 3.3e-01 | 1.10e-01 | 7.2e-01 | -4.00e-02 | 8.8e-01 | 4.00e-01 | 1.0e-02 | 2.00e-01 | 6.1e-01 | 1.15e+00 | 0.0e+00 |
| 313 | Smarcd3 | -1.80e-01 | 6.3e-01 | 2.50e-01 | 4.9e-01 | -3.60e-01 | 4.5e-01 | -4.40e-01 | 5.1e-01 | 1.20e-01 | 8.1e-01 | 1.16e+00 | 0.0e+00 |
| 143 | Gpd1 | -3.90e-01 | 4.2e-01 | 1.57e+00 | 0.0e+00 | 1.00e-01 | 8.4e-01 | 3.90e-01 | 0.0e+00 | 4.10e-01 | 8.0e-02 | 1.16e+00 | 0.0e+00 |
| 89 | Cyp4b1 | 1.80e-01 | 4.1e-01 | -1.40e-01 | 8.3e-01 | 4.30e-01 | 4.0e-02 | 4.30e-01 | 2.7e-01 | 3.50e-01 | 3.1e-01 | 1.18e+00 | 0.0e+00 |
| 48 | Arntl | 6.60e-01 | 0.0e+00 | 2.90e-01 | 9.0e-02 | 2.35e+00 | 0.0e+00 | 8.70e-01 | 0.0e+00 | 9.70e-01 | 0.0e+00 | 1.19e+00 | 0.0e+00 |
| 126 | Fdx1l | 2.30e-01 | 5.8e-01 | 4.00e-01 | 3.1e-01 | 1.50e-01 | 8.0e-01 | 8.00e-02 | 9.4e-01 | 1.50e-01 | 8.3e-01 | 1.19e+00 | 0.0e+00 |
| 300 | Sec24a | -2.00e-02 | 9.7e-01 | -2.00e-02 | 9.9e-01 | 3.90e-01 | 2.4e-01 | 1.00e-01 | 9.2e-01 | 4.90e-01 | 1.3e-01 | 1.22e+00 | 0.0e+00 |
| 236 | Pik3r1 | 1.10e-01 | 7.6e-01 | 1.00e-01 | 8.6e-01 | -7.00e-02 | 8.4e-01 | 5.90e-01 | 0.0e+00 | 3.70e-01 | 9.0e-02 | 1.27e+00 | 0.0e+00 |
| 171 | Lclat1 | -2.30e-01 | 3.1e-01 | -1.40e-01 | 7.8e-01 | -3.60e-01 | 2.0e-01 | 0.00e+00 | 1.0e+00 | 6.00e-02 | 9.2e-01 | 1.29e+00 | 0.0e+00 |
| 316 | Sphk1 | 2.18e+00 | 0.0e+00 | -1.10e-01 | 8.7e-01 | -4.50e-01 | 3.0e-02 | 1.60e-01 | 8.8e-01 | 1.12e+00 | 0.0e+00 | 1.30e+00 | 1.0e-02 |
| 175 | Lpin1 | 6.70e-01 | 0.0e+00 | 2.20e-01 | 5.0e-01 | -4.20e-01 | 1.3e-01 | 1.66e+00 | 0.0e+00 | 5.70e-01 | 4.0e-02 | 1.33e+00 | 0.0e+00 |
| 83 | Cyp27a1 | -1.00e-01 | 6.1e-01 | -4.00e-02 | 9.6e-01 | -5.50e-01 | 2.0e-02 | 3.40e-01 | 1.3e-01 | -7.00e-02 | 9.0e-01 | 1.59e+00 | 0.0e+00 |
| 118 | Fam213b | -5.00e-02 | 9.4e-01 | 2.80e-01 | 4.9e-01 | -9.00e-02 | 8.8e-01 | 1.10e-01 | 8.8e-01 | -1.50e-01 | 8.3e-01 | 1.61e+00 | 0.0e+00 |
| 270 | Pnpla7 | 3.00e-01 | 1.1e-01 | 3.00e-01 | 1.9e-01 | -5.00e-02 | 8.8e-01 | 6.50e-01 | 0.0e+00 | 7.70e-01 | 0.0e+00 | 1.79e+00 | 0.0e+00 |
| 267 | Pnmt | 3.10e-01 | 5.3e-01 | 5.00e-02 | NA | 2.80e-01 | 5.7e-01 | 1.10e-01 | NA | 5.00e-02 | NA | 1.85e+00 | 0.0e+00 |
| 220 | Osbpl7 | 2.00e-02 | 9.5e-01 | 1.30e-01 | 7.3e-01 | -1.50e-01 | 6.0e-01 | 5.30e-01 | 2.0e-02 | -1.30e-01 | 7.3e-01 | 1.91e+00 | 0.0e+00 |
| 18 | Acot11 | -3.90e-01 | 2.7e-01 | 6.00e-02 | 9.0e-01 | -9.00e-02 | 9.1e-01 | 1.00e-02 | NA | -1.40e-01 | 8.6e-01 | 2.30e+00 | 0.0e+00 |
| 71 | Cpne6 | 3.00e-01 | 5.2e-01 | 3.10e-01 | 1.8e-01 | -2.10e-01 | 8.0e-01 | -2.00e-02 | NA | NA | NA | 3.04e+00 | 0.0e+00 |
| 37 | Akr1c1 | -4.00e-01 | 1.5e-01 | 0.00e+00 | NA | -5.40e-01 | 3.4e-01 | -1.05e+00 | 0.0e+00 | -2.80e-01 | NA | NA | NA |
| 81 | Cyp17a1 | -2.00e-02 | NA | -9.00e-02 | NA | -2.10e-01 | NA | 1.85e+00 | 0.0e+00 | NA | NA | NA | NA |
| 90 | Cyp7a1 | -2.80e-01 | 4.3e-01 | 6.00e-02 | 8.7e-01 | -4.40e-01 | 4.2e-01 | 9.90e-01 | 2.0e-02 | NA | NA | NA | NA |
| 114 | Fabp7 | -3.50e-01 | 4.1e-01 | -3.00e-02 | 9.7e-01 | -1.12e+00 | 3.0e-02 | -9.40e-01 | 0.0e+00 | NA | NA | NA | NA |
| 151 | Hao2 | -2.50e-01 | 5.6e-01 | 5.00e-02 | 9.3e-01 | 1.00e-02 | 9.8e-01 | -1.00e+00 | 0.0e+00 | -1.00e-02 | NA | NA | NA |
| 312 | Slco1a2 | 1.38e+00 | 0.0e+00 | -2.50e-01 | NA | 8.80e-01 | 1.0e-01 | 1.90e-01 | 8.3e-01 | -1.00e-02 | NA | NA | NA |
| 320 | Sptssb | -4.00e-02 | NA | -4.80e-01 | 1.0e-02 | -1.04e+00 | 2.0e-02 | -1.00e-02 | NA | NA | NA | NA | NA |
LipidMet %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S25. Relative changes in the expression of genes involved in lipid metabolism after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))AcuteInflamm%>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>%kable(caption = "Supplementary Table 26. Relative changes in the expression of genes involved in acute inflammatory response after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(AcuteInflamm$Adrenal_padj),F,ifelse(AcuteInflamm$Adrenal_padj<.1,T,F)),color= ifelse(is.na(AcuteInflamm$Adrenal_padj),"gray",ifelse(AcuteInflamm$Adrenal_padj<.1,spec_color(AcuteInflamm$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(AcuteInflamm$HT_padj),F,ifelse(AcuteInflamm$HT_padj<.1,T,F)),color= ifelse(is.na(AcuteInflamm$HT_padj),"gray",ifelse(AcuteInflamm$HT_padj<.1,spec_color(AcuteInflamm$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(AcuteInflamm$Liver_padj),F,ifelse(AcuteInflamm$Liver_padj<.1,T,F)),color= ifelse(is.na(AcuteInflamm$Liver_padj),"gray",ifelse(AcuteInflamm$Liver_padj<.1,spec_color(AcuteInflamm$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(AcuteInflamm$Lung_padj),F,ifelse(AcuteInflamm$Lung_padj<.1,T,F)),color= ifelse(is.na(AcuteInflamm$Lung_padj),"gray",ifelse(AcuteInflamm$Lung_padj <.1,spec_color(AcuteInflamm$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(AcuteInflamm$Adipose_padj),F,ifelse(AcuteInflamm$Adipose_padj<.1,T,F)),color= ifelse(is.na(AcuteInflamm$Adipose_padj),"gray",ifelse(AcuteInflamm$Adipose_padj<.1, spec_color(AcuteInflamm$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(AcuteInflamm$Muscle_padj),F,ifelse(AcuteInflamm$Muscle_padj<.1,T,F)),color= ifelse(is.na(AcuteInflamm$Muscle_padj),"gray",ifelse(AcuteInflamm$Muscle_padj<.1,spec_color(AcuteInflamm$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 8 | Selp | 1.97e+00 | 0.0e+00 | 1.2e-01 | NA | 2.1e-01 | 7.9e-01 | -5.5e-01 | 1.2e-01 | -6.1e-01 | 1.5e-01 | -2.58e+00 | 0e+00 |
| 3 | Icam1 | -1.40e-01 | 5.1e-01 | -3.4e-01 | 4.2e-01 | 5.9e-01 | 2.0e-02 | 4.1e-01 | 6.0e-02 | -5.0e-02 | 9.2e-01 | -1.50e+00 | 0e+00 |
| 2 | C6 | -3.10e-01 | 5.1e-01 | -8.0e-02 | 9.2e-01 | 3.0e-02 | 9.4e-01 | -2.2e-01 | 3.5e-01 | -1.0e-02 | 9.8e-01 | -1.39e+00 | 1e-02 |
| 1 | C3 | -2.60e-01 | 3.8e-01 | 2.0e-02 | 9.8e-01 | -5.6e-01 | 3.6e-01 | -6.0e-02 | 7.8e-01 | -2.1e-01 | 7.7e-01 | -1.35e+00 | 1e-02 |
| 6 | Itgal | -4.70e-01 | 0.0e+00 | -2.7e-01 | 4.9e-01 | -4.8e-01 | 1.1e-01 | -1.9e-01 | 7.1e-01 | -8.7e-01 | 0.0e+00 | -1.19e+00 | 0e+00 |
| 9 | Vcam1 | 1.00e-02 | 9.7e-01 | -1.0e-01 | 7.3e-01 | 9.0e-02 | 8.3e-01 | 5.6e-01 | 0.0e+00 | -1.9e-01 | 3.5e-01 | -9.60e-01 | 0e+00 |
| 7 | Itgb2 | 1.00e-02 | 9.5e-01 | -7.0e-02 | 8.8e-01 | 2.0e-02 | 9.6e-01 | 1.0e-01 | 8.4e-01 | -1.3e-01 | 7.8e-01 | -7.80e-01 | 2e-02 |
| 5 | Itga4 | -5.70e-01 | 9.0e-02 | -2.6e-01 | 6.2e-01 | 2.0e-02 | 9.7e-01 | -6.0e-02 | 9.6e-01 | -3.1e-01 | 5.2e-01 | 8.70e-01 | 0e+00 |
| 4 | Il1a | 1.28e+00 | 0.0e+00 | -3.3e-01 | 4.9e-01 | 7.4e-01 | 2.4e-01 | -3.9e-01 | 3.3e-01 | -4.0e-02 | NA | NA | NA |
AcuteInflamm %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S26. Relative changes in the expression of genes involved in acute inflammatory response after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))Chemokine%>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>%kable(caption = "Supplementary Table 27. Relative changes in the expression of genes involved in chemokine signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(Chemokine$Adrenal_padj),F,ifelse(Chemokine$Adrenal_padj<.1,T,F)),color= ifelse(is.na(Chemokine$Adrenal_padj),"gray",ifelse(Chemokine$Adrenal_padj<.1,spec_color(Chemokine$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(Chemokine$HT_padj),F,ifelse(Chemokine$HT_padj<.1,T,F)),color= ifelse(is.na(Chemokine$HT_padj),"gray",ifelse(Chemokine$HT_padj<.1,spec_color(Chemokine$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(Chemokine$Liver_padj),F,ifelse(Chemokine$Liver_padj<.1,T,F)),color= ifelse(is.na(Chemokine$Liver_padj),"gray",ifelse(Chemokine$Liver_padj<.1,spec_color(Chemokine$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(Chemokine$Lung_padj),F,ifelse(Chemokine$Lung_padj<.1,T,F)),color= ifelse(is.na(Chemokine$Lung_padj),"gray",ifelse(Chemokine$Lung_padj <.1,spec_color(Chemokine$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(Chemokine$Adipose_padj),F,ifelse(Chemokine$Adipose_padj<.1,T,F)),color= ifelse(is.na(Chemokine$Adipose_padj),"gray",ifelse(Chemokine$Adipose_padj<.1, spec_color(Chemokine$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(Chemokine$Muscle_padj),F,ifelse(Chemokine$Muscle_padj<.1,T,F)),color= ifelse(is.na(Chemokine$Muscle_padj),"gray",ifelse(Chemokine$Muscle_padj<.1,spec_color(Chemokine$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 15 | Flrt3 | -6.6e-01 | 0.0e+00 | -2.2e-01 | 4.2e-01 | 6.20e-01 | 2.0e-02 | -5.50e-01 | 3.4e-01 | -5.90e-01 | 6.0e-02 | -1.80e+00 | 0.0e+00 |
| 5 | Fgf16 | -1.4e-01 | 8.0e-01 | 1.0e-02 | NA | -9.90e-01 | 8.0e-02 | 1.00e-02 | NA | -1.00e-02 | 9.9e-01 | -1.23e+00 | 2.0e-02 |
| 7 | Fgf9 | -4.4e-01 | 2.8e-01 | -3.7e-01 | 5.0e-02 | -7.30e-01 | 1.0e-01 | -9.00e-02 | NA | -1.80e-01 | 8.0e-01 | -1.13e+00 | 1.0e-02 |
| 14 | Flrt2 | 3.7e-01 | 2.6e-01 | -4.5e-01 | 2.7e-01 | 2.50e-01 | 4.2e-01 | -7.00e-02 | 9.6e-01 | 1.80e-01 | 7.8e-01 | -1.12e+00 | 0.0e+00 |
| 13 | Flrt1 | -4.1e-01 | 3.9e-01 | -2.6e-01 | 4.4e-01 | -2.30e-01 | 7.2e-01 | -5.00e-02 | 9.7e-01 | -4.20e-01 | 5.0e-01 | -1.11e+00 | 0.0e+00 |
| 3 | Fgf1 | -1.0e-01 | 5.3e-01 | -1.6e-01 | 4.2e-01 | -8.00e-02 | 8.7e-01 | -3.60e-01 | 3.7e-01 | -1.40e-01 | 7.2e-01 | -1.07e+00 | 0.0e+00 |
| 4 | Fgf10 | 2.0e-02 | 9.6e-01 | 2.0e-02 | 9.8e-01 | -4.30e-01 | 3.9e-01 | -3.30e-01 | 6.0e-01 | -7.90e-01 | 1.0e-02 | -1.05e+00 | 2.0e-02 |
| 39 | Spred1 | -1.0e-01 | 8.2e-01 | -2.1e-01 | 7.2e-01 | 1.40e-01 | 7.3e-01 | -5.30e-01 | 2.1e-01 | -1.50e-01 | 7.4e-01 | -1.01e+00 | 0.0e+00 |
| 26 | Ncbp2 | -1.1e-01 | 3.8e-01 | -4.0e-02 | 9.4e-01 | -4.50e-01 | 4.0e-02 | -3.00e-01 | 8.0e-02 | 1.00e-01 | 7.7e-01 | -9.40e-01 | 0.0e+00 |
| 23 | Klb | -2.2e-01 | 5.1e-01 | 6.0e-02 | NA | 1.40e-01 | 8.6e-01 | -8.00e-02 | 9.2e-01 | 7.40e-01 | 3.0e-02 | -7.90e-01 | 2.6e-01 |
| 10 | Fgfr2 | -2.7e-01 | 3.0e-02 | -5.0e-02 | 9.1e-01 | 4.20e-01 | 2.0e-02 | -8.70e-01 | 0.0e+00 | -1.18e+00 | 0.0e+00 | -7.10e-01 | 1.8e-01 |
| 24 | Mapk3 | 2.4e-01 | 5.0e-02 | 4.0e-02 | 9.5e-01 | 1.10e-01 | 7.1e-01 | 4.40e-01 | 5.0e-02 | 5.00e-02 | 9.3e-01 | -6.90e-01 | 0.0e+00 |
| 40 | Spred2 | 3.0e-02 | 9.0e-01 | -3.0e-01 | 3.4e-01 | 4.20e-01 | 1.3e-01 | 1.00e-02 | 1.0e+00 | -1.80e-01 | 5.3e-01 | -6.90e-01 | 0.0e+00 |
| 9 | Fgfr1 | -2.6e-01 | 3.5e-01 | 3.0e-02 | 9.6e-01 | 4.10e-01 | 0.0e+00 | -2.80e-01 | 6.0e-01 | -2.60e-01 | 3.9e-01 | -6.30e-01 | 1.0e-02 |
| 18 | Galnt3 | -6.0e-01 | 0.0e+00 | 5.0e-02 | 9.5e-01 | 1.61e+00 | 0.0e+00 | -1.90e-01 | NA | -1.00e-01 | NA | -6.20e-01 | NA |
| 34 | Ppp2ca | 1.3e-01 | 7.3e-01 | -6.0e-02 | 9.2e-01 | 2.90e-01 | 5.9e-01 | 1.07e+00 | 0.0e+00 | 4.80e-01 | 2.5e-01 | -5.40e-01 | 1.0e-01 |
| 35 | Ppp2cb | 9.0e-02 | 5.4e-01 | -2.0e-02 | 9.8e-01 | 6.00e-01 | 6.0e-02 | -1.40e-01 | 8.1e-01 | 3.10e-01 | 3.8e-01 | -4.70e-01 | 9.0e-02 |
| 36 | Ptbp1 | -2.0e-02 | 9.5e-01 | 0.0e+00 | 1.0e+00 | 8.10e-01 | 0.0e+00 | -4.00e-02 | 9.4e-01 | -4.00e-02 | 9.0e-01 | -2.90e-01 | 1.4e-01 |
| 12 | Fgfr4 | -7.2e-01 | 0.0e+00 | -2.3e-01 | 6.8e-01 | -1.80e-01 | 7.5e-01 | -2.80e-01 | 6.0e-02 | -9.20e-01 | 5.0e-02 | -1.60e-01 | 6.1e-01 |
| 21 | Hnrnpa1 | 2.3e-01 | 1.0e-02 | 2.3e-01 | 1.0e-01 | 9.80e-01 | 0.0e+00 | 4.70e-01 | 0.0e+00 | 5.10e-01 | 1.0e-02 | -9.00e-02 | 5.4e-01 |
| 11 | Fgfr3 | -1.3e-01 | 3.9e-01 | 2.2e-01 | 2.4e-01 | 2.70e-01 | 1.5e-01 | 2.70e-01 | 1.9e-01 | 7.20e-01 | 3.0e-02 | -5.00e-02 | 9.3e-01 |
| 38 | Sos1 | 2.0e-02 | 9.6e-01 | -2.3e-01 | 5.7e-01 | 1.10e-01 | 7.1e-01 | 5.90e-01 | 1.0e-02 | -1.00e-02 | 9.8e-01 | 1.00e-01 | 6.3e-01 |
| 8 | Fgfbp1 | -9.1e-01 | 0.0e+00 | -6.0e-02 | NA | 1.90e-01 | NA | -1.90e-01 | NA | -5.90e-01 | NA | 1.50e-01 | NA |
| 16 | Frs3 | -3.1e-01 | 4.6e-01 | 1.2e-01 | 7.7e-01 | -1.80e-01 | 7.6e-01 | -1.60e-01 | 8.5e-01 | -7.30e-01 | 2.0e-02 | 2.10e-01 | 6.3e-01 |
| 28 | Polr2d | 2.5e-01 | 9.0e-02 | 3.4e-01 | 2.2e-01 | 1.50e-01 | 6.9e-01 | 5.10e-01 | 0.0e+00 | 6.70e-01 | 0.0e+00 | 2.50e-01 | 2.0e-01 |
| 37 | Ptpn11 | 2.4e-01 | 2.0e-02 | 3.3e-01 | 5.0e-02 | -2.00e-01 | 5.1e-01 | -1.00e-02 | 9.9e-01 | 9.50e-01 | 0.0e+00 | 4.00e-01 | 0.0e+00 |
| 1 | Braf | -1.4e-01 | 7.6e-01 | -1.2e-01 | 8.7e-01 | 9.10e-01 | 1.0e-02 | 0.00e+00 | 1.0e+00 | 6.20e-01 | 9.0e-02 | 4.70e-01 | 5.0e-02 |
| 25 | Mknk1 | 1.0e-01 | 5.0e-01 | 1.0e-01 | 8.2e-01 | -5.40e-01 | 0.0e+00 | 7.00e-01 | 0.0e+00 | 8.60e-01 | 0.0e+00 | 4.90e-01 | 3.0e-02 |
| 20 | Gtf2f2 | -5.0e-02 | 8.6e-01 | 4.0e-02 | 9.5e-01 | 7.10e-01 | 0.0e+00 | -3.00e-02 | 9.8e-01 | 3.30e-01 | 2.0e-01 | 5.10e-01 | 1.0e-02 |
| 41 | Ubb | 4.4e-01 | 0.0e+00 | 2.6e-01 | 2.5e-01 | -7.80e-01 | 0.0e+00 | 1.00e-01 | 8.6e-01 | 1.10e-01 | 7.6e-01 | 6.00e-01 | 0.0e+00 |
| 29 | Polr2e | 1.0e-01 | 7.5e-01 | 4.5e-01 | 1.4e-01 | 1.00e-02 | 9.9e-01 | -1.00e-02 | 9.9e-01 | 1.00e-01 | 8.7e-01 | 7.40e-01 | 2.0e-02 |
| 19 | Gtf2f1 | 5.3e-01 | 1.0e-02 | 3.9e-01 | 2.0e-01 | 3.50e-01 | 3.6e-01 | 6.40e-01 | 5.0e-02 | 5.90e-01 | 5.0e-02 | 7.60e-01 | 0.0e+00 |
| 32 | Polr2k | 1.6e-01 | 5.6e-01 | 2.8e-01 | 3.2e-01 | -1.50e-01 | 7.2e-01 | 6.00e-02 | 9.5e-01 | 5.70e-01 | 1.8e-01 | 8.00e-01 | 1.0e-02 |
| 30 | Polr2f | -2.3e-01 | 5.4e-01 | 3.9e-01 | 3.4e-01 | 8.00e-02 | 8.9e-01 | 0.00e+00 | 1.0e+00 | 2.20e-01 | 6.5e-01 | 8.10e-01 | 2.0e-02 |
| 17 | Gab1 | 1.2e-01 | 6.9e-01 | -3.7e-01 | 3.7e-01 | -2.40e-01 | 5.5e-01 | -2.30e-01 | 6.7e-01 | -1.60e-01 | 6.5e-01 | 1.00e+00 | 0.0e+00 |
| 33 | Polr2l | 9.0e-02 | 8.8e-01 | 2.6e-01 | 6.1e-01 | 2.10e-01 | 7.1e-01 | 3.00e-02 | 9.8e-01 | 2.20e-01 | 7.7e-01 | 1.01e+00 | 0.0e+00 |
| 31 | Polr2j | -9.0e-02 | 8.2e-01 | 2.6e-01 | 5.5e-01 | -3.20e-01 | 4.5e-01 | -1.00e-02 | 1.0e+00 | 2.20e-01 | 7.2e-01 | 1.06e+00 | 0.0e+00 |
| 2 | Esrp2 | 2.9e-01 | 4.0e-02 | -1.0e-02 | 9.9e-01 | -2.80e-01 | 4.6e-01 | 3.00e-01 | 3.0e-02 | 9.30e-01 | 1.0e-02 | 1.21e+00 | 8.0e-02 |
| 27 | Pik3r1 | 1.1e-01 | 7.6e-01 | 1.0e-01 | 8.6e-01 | -7.00e-02 | 8.4e-01 | 5.90e-01 | 0.0e+00 | 3.70e-01 | 9.0e-02 | 1.27e+00 | 0.0e+00 |
| 22 | Hras | 1.3e-01 | 6.7e-01 | 3.9e-01 | 2.0e-01 | 1.10e-01 | 8.3e-01 | 2.10e-01 | 6.9e-01 | -2.00e-02 | 9.6e-01 | 1.46e+00 | 0.0e+00 |
| 42 | Ubc | 9.3e-01 | 0.0e+00 | 1.2e-01 | 7.0e-01 | -2.90e-01 | 3.1e-01 | -7.50e-01 | 0.0e+00 | 3.10e-01 | 2.4e-01 | 1.48e+00 | 0.0e+00 |
| 6 | Fgf2 | 3.9e-01 | 4.2e-01 | 5.1e-01 | 1.9e-01 | -7.70e-01 | 2.0e-01 | 2.50e-01 | NA | 1.22e+00 | 0.0e+00 | 1.91e+00 | 0.0e+00 |
Chemokine %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S27. Relative changes in the expression of genes involved in chemokine signaling after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))Immunoregulatory%>% mutate(
Adrenal_padj=format(round(Adrenal_padj,2),nsmall=2,scientific=TRUE),
Adrenal_log2FoldChange=format(round(Adrenal_log2FoldChange,2),nsmall=2,scientific=TRUE),
Adipose_padj=format(round(Adipose_padj,2),nsmall=2,scientific=TRUE),
Adipose_log2FoldChange=format(round(Adipose_log2FoldChange,2),nsmall=2,scientific=TRUE),
Liver_padj=format(round(Liver_padj,2),nsmall=2,scientific=TRUE),
Liver_log2FoldChange=format(round(Liver_log2FoldChange,2),nsmall=2,scientific=TRUE),
Lung_padj=format(round(Lung_padj,2),nsmall=2,scientific=TRUE),
Lung_log2FoldChange=format(round(Lung_log2FoldChange,2),nsmall=2,scientific=TRUE),
HT_padj=format(round(HT_padj,2),nsmall=2,scientific=TRUE),
HT_log2FoldChange=format(round(HT_log2FoldChange,2),nsmall=2,scientific=TRUE),
Muscle_padj=format(round(Muscle_padj,2),nsmall=2,scientific=TRUE),
Muscle_log2FoldChange=format(round(Muscle_log2FoldChange,2),nsmall=2,scientific=TRUE)) %>%kable(caption = "Supplementary Table 28. Relative changes in the expression of genes involved in Immunoregulatory interactions after ozone exposure in tissues, ordered by the log 2-fold change in the muscle", escape = F) %>%
kable_classic(full_width = F, position = "left",html_font = "Cambria") %>% kable_styling(bootstrap_options = c("striped","hover","responsive","condensed")) %>%
column_spec(c(7:8),bold=ifelse(is.na(Immunoregulatory$Adrenal_padj),F,ifelse(Immunoregulatory$Adrenal_padj<.1,T,F)),color= ifelse(is.na(Immunoregulatory$Adrenal_padj),"gray",ifelse(Immunoregulatory$Adrenal_padj<.1,spec_color(Immunoregulatory$Adrenal_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(5:6),bold=ifelse(is.na(Immunoregulatory$HT_padj),F,ifelse(Immunoregulatory$HT_padj<.1,T,F)),color= ifelse(is.na(Immunoregulatory$HT_padj),"gray",ifelse(Immunoregulatory$HT_padj<.1,spec_color(Immunoregulatory$HT_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(9:10),bold=ifelse(is.na(Immunoregulatory$Liver_padj),F,ifelse(Immunoregulatory$Liver_padj<.1,T,F)),color= ifelse(is.na(Immunoregulatory$Liver_padj),"gray",ifelse(Immunoregulatory$Liver_padj<.1,spec_color(Immunoregulatory$Liver_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(3:4),bold=ifelse(is.na(Immunoregulatory$Lung_padj),F,ifelse(Immunoregulatory$Lung_padj<.1,T,F)),color= ifelse(is.na(Immunoregulatory$Lung_padj),"gray",ifelse(Immunoregulatory$Lung_padj <.1,spec_color(Immunoregulatory$Lung_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(11:12),bold=ifelse(is.na(Immunoregulatory$Adipose_padj),F,ifelse(Immunoregulatory$Adipose_padj<.1,T,F)),color= ifelse(is.na(Immunoregulatory$Adipose_padj),"gray",ifelse(Immunoregulatory$Adipose_padj<.1, spec_color(Immunoregulatory$Adipose_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
column_spec(c(13:14),bold=ifelse(is.na(Immunoregulatory$Muscle_padj),F,ifelse(Immunoregulatory$Muscle_padj<.1,T,F)),color= ifelse(is.na(Immunoregulatory$Muscle_padj),"gray",ifelse(Immunoregulatory$Muscle_padj<.1,spec_color(Immunoregulatory$Muscle_log2FoldChange,n=11,direction=-1,option='D'),"gray"))) %>%
scroll_box(width = "1200px", height = "500px")| gene | Lung_log2FoldChange | Lung_padj | HT_log2FoldChange | HT_padj | Adrenal_log2FoldChange | Adrenal_padj | Liver_log2FoldChange | Liver_padj | Adipose_log2FoldChange | Adipose_padj | Muscle_log2FoldChange | Muscle_padj | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 16 | Cdh1 | 2.80e-01 | 1.0e-02 | -3.0e-01 | 5.0e-01 | 4.60e-01 | 3.8e-01 | -4.40e-01 | 1.0e-02 | 4.8e-01 | NA | -2.48e+00 | 0.0e+00 |
| 8 | Cd300lb | -7.10e-01 | 0.0e+00 | 1.0e-02 | NA | 1.00e-01 | 9.1e-01 | -1.70e-01 | NA | -1.6e-01 | 7.5e-01 | -2.32e+00 | 0.0e+00 |
| 40 | Mal | -3.50e-01 | 1.1e-01 | 2.9e-01 | 9.0e-02 | -1.20e-01 | 8.2e-01 | -8.00e-02 | 9.5e-01 | 4.1e-01 | 4.9e-01 | -2.08e+00 | 0.0e+00 |
| 20 | Col2a1 | -6.50e-01 | 7.0e-02 | 4.0e-02 | 9.5e-01 | 1.13e+00 | 4.0e-02 | NA | NA | 5.1e-01 | NA | -1.99e+00 | 0.0e+00 |
| 10 | Cd300lf | 1.00e-02 | 9.6e-01 | -4.6e-01 | 1.7e-01 | -8.50e-01 | 5.0e-02 | -7.90e-01 | 0.0e+00 | -9.4e-01 | 3.0e-02 | -1.90e+00 | 1.0e-02 |
| 36 | Lilrb3 | -1.20e+00 | 0.0e+00 | -5.1e-01 | 1.8e-01 | -1.36e+00 | 0.0e+00 | -4.30e-01 | 3.0e-02 | -7.1e-01 | 6.0e-02 | -1.87e+00 | 0.0e+00 |
| 19 | Col1a1 | -3.80e-01 | 2.0e-01 | -1.4e-01 | 8.0e-01 | 1.60e-01 | 5.5e-01 | -4.00e-02 | 9.8e-01 | 4.8e-01 | 2.6e-01 | -1.60e+00 | 0.0e+00 |
| 21 | Col3a1 | -3.00e-01 | 5.0e-02 | -1.7e-01 | 7.4e-01 | 1.30e-01 | 6.2e-01 | 5.00e-02 | 9.5e-01 | 3.8e-01 | 9.0e-02 | -1.55e+00 | 0.0e+00 |
| 27 | Icam1 | -1.40e-01 | 5.1e-01 | -3.4e-01 | 4.2e-01 | 5.90e-01 | 2.0e-02 | 4.10e-01 | 6.0e-02 | -5.0e-02 | 9.2e-01 | -1.50e+00 | 0.0e+00 |
| 48 | Siglec5 | -5.90e-01 | 0.0e+00 | -3.0e-01 | 5.2e-01 | -7.90e-01 | 1.5e-01 | -1.00e-02 | 9.9e-01 | -5.3e-01 | 7.0e-02 | -1.49e+00 | 0.0e+00 |
| 51 | Trem2 | 2.50e-01 | 5.2e-01 | -5.5e-01 | 8.0e-02 | -5.10e-01 | 3.8e-01 | -2.30e-01 | NA | -5.3e-01 | 2.2e-01 | -1.41e+00 | 2.0e-02 |
| 12 | Cd34 | -2.60e-01 | 1.2e-01 | -3.3e-01 | 3.6e-01 | 6.00e-02 | 8.5e-01 | -1.30e-01 | NA | -8.0e-02 | 8.8e-01 | -1.40e+00 | 0.0e+00 |
| 2 | C3 | -2.60e-01 | 3.8e-01 | 2.0e-02 | 9.8e-01 | -5.60e-01 | 3.6e-01 | -6.00e-02 | 7.8e-01 | -2.1e-01 | 7.7e-01 | -1.35e+00 | 1.0e-02 |
| 11 | Cd33 | 1.00e-02 | 9.8e-01 | -5.5e-01 | 9.0e-02 | -2.90e-01 | 7.0e-01 | 2.90e-01 | 7.3e-01 | -4.9e-01 | 3.1e-01 | -1.35e+00 | 3.0e-02 |
| 49 | Siglec8 | -8.00e-02 | 7.5e-01 | 0.0e+00 | 1.0e+00 | -2.60e-01 | 6.4e-01 | -1.00e-02 | 9.9e-01 | -2.7e-01 | 5.6e-01 | -1.29e+00 | 2.0e-02 |
| 9 | Cd300le | -2.90e-01 | 3.6e-01 | -4.4e-01 | 2.8e-01 | -3.00e-01 | 4.7e-01 | -1.10e-01 | 8.9e-01 | 1.6e-01 | 7.3e-01 | -1.20e+00 | 0.0e+00 |
| 26 | Fcgr3a | -1.20e-01 | 3.9e-01 | -5.0e-01 | 1.0e-01 | 0.00e+00 | 1.0e+00 | -3.50e-01 | 3.8e-01 | -3.7e-01 | 4.3e-01 | -1.20e+00 | 7.0e-02 |
| 30 | Itgal | -4.70e-01 | 0.0e+00 | -2.7e-01 | 4.9e-01 | -4.80e-01 | 1.1e-01 | -1.90e-01 | 7.1e-01 | -8.7e-01 | 0.0e+00 | -1.19e+00 | 0.0e+00 |
| 24 | Fcgr1a | -2.10e-01 | 3.6e-01 | -1.6e-01 | 7.9e-01 | -1.80e-01 | 6.2e-01 | -2.90e-01 | 5.4e-01 | -2.0e-01 | 6.8e-01 | -1.18e+00 | 2.0e-02 |
| 47 | Siglec10 | 2.80e-01 | 5.0e-02 | -1.0e-02 | NA | 6.70e-01 | 2.8e-01 | -2.80e-01 | 7.3e-01 | 2.6e-01 | 4.9e-01 | -1.14e+00 | 2.0e-02 |
| 4 | Cd200 | -2.10e-01 | 3.8e-01 | 4.0e-02 | 9.4e-01 | 8.70e-01 | 0.0e+00 | -3.50e-01 | 6.4e-01 | -2.7e-01 | 5.6e-01 | -1.13e+00 | 0.0e+00 |
| 7 | Cd226 | -5.10e-01 | 7.0e-02 | 2.7e-01 | 6.0e-01 | 3.20e-01 | 6.6e-01 | -4.20e-01 | 4.5e-01 | -1.4e-01 | 8.4e-01 | -1.12e+00 | 0.0e+00 |
| 22 | Colec12 | -9.00e-02 | 6.6e-01 | -1.7e-01 | 7.6e-01 | 1.10e-01 | 7.4e-01 | -1.00e-01 | 9.4e-01 | 2.7e-01 | 2.7e-01 | -1.05e+00 | 0.0e+00 |
| 6 | Cd22 | -1.09e+00 | 0.0e+00 | 1.6e-01 | 8.0e-01 | -3.00e-01 | 3.3e-01 | -1.50e-01 | 8.1e-01 | -6.1e-01 | 5.0e-02 | -1.03e+00 | 1.0e-02 |
| 1 | B2m | 8.00e-02 | 6.1e-01 | 7.0e-02 | 8.9e-01 | 1.30e-01 | 7.2e-01 | -2.40e-01 | 3.5e-01 | 6.0e-02 | 9.0e-01 | -9.70e-01 | 0.0e+00 |
| 53 | Vcam1 | 1.00e-02 | 9.7e-01 | -1.0e-01 | 7.3e-01 | 9.00e-02 | 8.3e-01 | 5.60e-01 | 0.0e+00 | -1.9e-01 | 3.5e-01 | -9.60e-01 | 0.0e+00 |
| 23 | Cxadr | -2.30e-01 | 4.8e-01 | -1.8e-01 | 7.7e-01 | 2.80e-01 | 6.1e-01 | -2.30e-01 | 7.1e-01 | -1.7e-01 | 8.2e-01 | -9.30e-01 | 3.0e-02 |
| 17 | Clec2d | 6.60e-01 | 2.0e-02 | -9.0e-02 | NA | 4.90e-01 | 4.7e-01 | -1.50e-01 | 8.6e-01 | 5.9e-01 | 2.0e-01 | -9.10e-01 | 1.3e-01 |
| 25 | Fcgr2b | 1.50e-01 | 4.7e-01 | 4.0e-02 | 9.3e-01 | 4.00e-02 | 9.6e-01 | -3.70e-01 | 2.0e-01 | 6.4e-01 | 1.0e-01 | -8.90e-01 | 1.0e-02 |
| 45 | Sell | -6.90e-01 | 1.0e-02 | -3.0e-02 | NA | 4.20e-01 | 5.4e-01 | -7.30e-01 | 1.7e-01 | -2.2e-01 | 7.0e-01 | -8.90e-01 | 1.7e-01 |
| 32 | Itgb7 | -9.30e-01 | 0.0e+00 | -8.0e-02 | 9.2e-01 | 1.20e-01 | 8.5e-01 | -5.70e-01 | 1.7e-01 | -6.9e-01 | 1.0e-02 | -8.90e-01 | 0.0e+00 |
| 44 | Pvr | 7.40e-01 | 0.0e+00 | -1.1e-01 | 8.2e-01 | 1.80e-01 | 6.6e-01 | 1.14e+00 | 0.0e+00 | 8.0e-01 | 0.0e+00 | -8.20e-01 | 2.0e-02 |
| 31 | Itgb2 | 1.00e-02 | 9.5e-01 | -7.0e-02 | 8.8e-01 | 2.00e-02 | 9.6e-01 | 1.00e-01 | 8.4e-01 | -1.3e-01 | 7.8e-01 | -7.80e-01 | 2.0e-02 |
| 5 | Cd200r1 | 2.80e-01 | 4.2e-01 | -1.0e-01 | 9.0e-01 | 8.30e-01 | 0.0e+00 | -2.00e-02 | 9.9e-01 | 1.3e-01 | 8.1e-01 | -7.20e-01 | 6.0e-02 |
| 18 | Col17a1 | 2.30e-01 | 2.5e-01 | 1.4e-01 | 8.5e-01 | 2.36e+00 | 0.0e+00 | -3.00e-02 | NA | -1.6e-01 | 8.2e-01 | -6.90e-01 | 2.8e-01 |
| 41 | Micb | -1.00e-02 | 9.5e-01 | -1.1e-01 | 8.8e-01 | 5.00e-02 | 9.0e-01 | -2.50e-01 | 7.7e-01 | -2.0e-02 | 9.6e-01 | -6.90e-01 | 2.0e-02 |
| 35 | Klrk1 | -7.00e-01 | 0.0e+00 | -1.0e-01 | NA | -1.02e+00 | 0.0e+00 | -4.40e-01 | 3.1e-01 | -4.6e-01 | 2.3e-01 | -6.70e-01 | 1.6e-01 |
| 37 | Lilrb4 | -3.70e-01 | 1.8e-01 | -1.9e-01 | NA | -6.50e-01 | 4.0e-02 | 2.50e-01 | 7.8e-01 | -4.4e-01 | 3.4e-01 | -5.70e-01 | 4.3e-01 |
| 43 | Pianp | 3.00e-02 | 9.6e-01 | 9.0e-02 | 7.8e-01 | 1.50e+00 | 0.0e+00 | -2.40e-01 | 7.1e-01 | -4.0e-02 | 9.7e-01 | -4.10e-01 | 6.0e-01 |
| 34 | Klrd1 | -6.20e-01 | 3.0e-02 | -3.0e-02 | NA | 3.40e-01 | 6.5e-01 | -8.30e-01 | 9.0e-02 | -2.2e-01 | 7.7e-01 | -4.10e-01 | 6.0e-01 |
| 50 | Slamf6 | -6.10e-01 | 5.0e-02 | -4.0e-02 | NA | -2.50e-01 | 7.5e-01 | -4.80e-01 | 2.2e-01 | 5.0e-02 | 9.6e-01 | -3.60e-01 | NA |
| 3 | Cd19 | -1.00e+00 | 1.0e-02 | 1.4e-01 | 8.2e-01 | 4.50e-01 | 3.8e-01 | -6.50e-01 | 2.4e-01 | -4.2e-01 | 4.8e-01 | -1.90e-01 | NA |
| 52 | Treml2 | -7.20e-01 | 7.0e-02 | -4.0e-02 | NA | -1.30e-01 | NA | -3.30e-01 | NA | -1.4e-01 | 8.7e-01 | -1.60e-01 | NA |
| 46 | Sftpd | 4.70e-01 | 0.0e+00 | -6.7e-01 | 1.0e-02 | 6.40e-01 | 2.1e-01 | -2.10e-01 | 7.9e-01 | 6.0e-02 | NA | -9.00e-02 | NA |
| 13 | Cd3g | -7.30e-01 | 4.0e-02 | 1.0e-02 | NA | 7.00e-02 | 9.4e-01 | -3.10e-01 | NA | -4.3e-01 | 4.4e-01 | -9.00e-02 | NA |
| 42 | Oscar | 4.40e-01 | 1.0e-02 | 1.2e-01 | 8.7e-01 | 1.25e+00 | 0.0e+00 | 6.10e-01 | 5.0e-02 | 1.3e-01 | 8.7e-01 | -3.00e-02 | 9.7e-01 |
| 14 | Cd40lg | -7.50e-01 | 4.0e-02 | 0.0e+00 | NA | -1.40e-01 | NA | -4.00e-02 | NA | 1.2e-01 | NA | 4.00e-02 | NA |
| 33 | Jaml | 5.10e-01 | 0.0e+00 | 2.3e-01 | 6.6e-01 | -8.00e-02 | 8.9e-01 | -2.50e-01 | 7.3e-01 | 7.7e-01 | 0.0e+00 | 5.00e-02 | 9.4e-01 |
| 28 | Icam5 | -7.10e-01 | 6.0e-02 | 3.6e-01 | 3.6e-01 | 3.00e-02 | 9.8e-01 | -3.00e-01 | 6.8e-01 | -9.0e-02 | 9.0e-01 | 1.70e-01 | 8.0e-01 |
| 15 | Cd8a | -9.30e-01 | 0.0e+00 | -2.2e-01 | NA | -2.00e-01 | 7.8e-01 | -6.30e-01 | 1.6e-01 | -7.9e-01 | 6.0e-02 | 2.30e-01 | 7.7e-01 |
| 38 | Madcam1 | -3.90e-01 | NA | 2.4e-01 | NA | 2.70e-01 | 7.3e-01 | -2.00e-02 | NA | -8.8e-01 | 6.0e-02 | 2.80e-01 | NA |
| 29 | Itga4 | -5.70e-01 | 9.0e-02 | -2.6e-01 | 6.2e-01 | 2.00e-02 | 9.7e-01 | -6.00e-02 | 9.6e-01 | -3.1e-01 | 5.2e-01 | 8.70e-01 | 0.0e+00 |
| 39 | Mafa | 2.10e-01 | 6.6e-01 | -1.2e-01 | NA | -1.90e-01 | NA | 1.00e-02 | NA | -5.5e-01 | 1.9e-01 | 1.70e+00 | 0.0e+00 |
Immunoregulatory %>% DT::datatable(extensions = 'Buttons',caption = "Supplementary Table S28. Relative changes in the expression of genes involved in immunoregulatory interactions after ozone exposure in tissues, ordered by the log 2-fold change in the muscle - downloadable",
options = list(dom = 'Blfrtip',
buttons = c('copy', 'csv', 'excel', 'pdf', 'print'),
lengthMenu = list(c(25,50,-1),
c(25,50,"All"))))Sys.info()## sysname release version nodename
## "Windows" "10 x64" "build 19045" "DESKTOP-20D8T06"
## machine login user effective_user
## "x86-64" "twjac91" "twjac91" "twjac91"sessionInfo()## R version 4.3.0 (2023-04-21 ucrt)
## Platform: x86_64-w64-mingw32/x64 (64-bit)
## Running under: Windows 10 x64 (build 19045)
##
## Matrix products: default
##
##
## locale:
## [1] LC_COLLATE=English_United States.utf8
## [2] LC_CTYPE=English_United States.utf8
## [3] LC_MONETARY=English_United States.utf8
## [4] LC_NUMERIC=C
## [5] LC_TIME=English_United States.utf8
##
## time zone: America/New_York
## tzcode source: internal
##
## attached base packages:
## [1] tools stats4 grid stats graphics grDevices utils
## [8] datasets methods base
##
## other attached packages:
## [1] ReactomeContentService4R_1.8.0 org.Hs.eg.db_3.17.0
## [3] AnnotationDbi_1.62.1 IRanges_2.34.0
## [5] S4Vectors_0.38.1 Biobase_2.60.0
## [7] BiocGenerics_0.46.0 multiGSEA_1.10.0
## [9] XGR_1.1.9 dnet_1.1.7
## [11] supraHex_1.38.0 hexbin_1.28.3
## [13] igraph_1.4.2 ComplexHeatmap_2.16.0
## [15] data.table_1.14.8 kableExtra_1.3.4.9000
## [17] lubridate_1.9.2 forcats_1.0.0
## [19] stringr_1.5.0 purrr_1.0.1
## [21] readr_2.1.4 tidyr_1.3.0
## [23] tibble_3.2.1 ggplot2_3.4.2
## [25] tidyverse_2.0.0 readxl_1.4.2
## [27] janitor_2.2.0 dplyr_1.1.2
##
## loaded via a namespace (and not attached):
## [1] splines_4.3.0 later_1.3.1
## [3] bitops_1.0-7 filelock_1.0.2
## [5] cellranger_1.1.0 ggnetwork_0.5.12
## [7] graph_1.78.0 lifecycle_1.0.3
## [9] Rdpack_2.4 doParallel_1.0.17
## [11] lattice_0.21-8 MASS_7.3-58.4
## [13] crosstalk_1.2.0 magrittr_2.0.3
## [15] sass_0.4.6 rmarkdown_2.21
## [17] jquerylib_0.1.4 yaml_2.3.7
## [19] plotrix_3.8-2 qqconf_1.3.2
## [21] httpuv_1.6.10 sn_2.1.1
## [23] cowplot_1.1.1 DBI_1.1.3
## [25] RColorBrewer_1.1-3 multcomp_1.4-23
## [27] zlibbioc_1.46.0 rvest_1.0.3
## [29] GenomicRanges_1.52.0 RCurl_1.98-1.12
## [31] TH.data_1.1-2 rappdirs_0.3.3
## [33] sandwich_3.0-2 circlize_0.4.15
## [35] GenomeInfoDbData_1.2.10 ggrepel_0.9.3
## [37] crul_1.3 TFisher_0.2.0
## [39] svglite_2.1.1 codetools_0.2-19
## [41] DT_0.27 xml2_1.3.4
## [43] tidyselect_1.2.0 shape_1.4.6
## [45] httpcode_0.3.0 matrixStats_0.63.0
## [47] BiocFileCache_2.8.0 metaboliteIDmapping_1.0.0
## [49] webshot_0.5.4 mathjaxr_1.6-0
## [51] jsonlite_1.8.4 GetoptLong_1.0.5
## [53] multtest_2.56.0 ellipsis_0.3.2
## [55] survival_3.5-5 iterators_1.0.14
## [57] systemfonts_1.0.4 foreach_1.5.2
## [59] Rcpp_1.0.10 glue_1.6.2
## [61] mnormt_2.1.1 xfun_0.39
## [63] metap_1.8 GenomeInfoDb_1.36.0
## [65] withr_2.5.0 numDeriv_2016.8-1.1
## [67] BiocManager_1.30.20 fastmap_1.1.1
## [69] fansi_1.0.4 digest_0.6.31
## [71] timechange_0.2.0 R6_2.5.1
## [73] mime_0.12 colorspace_2.1-0
## [75] RSQLite_2.3.1 utf8_1.2.3
## [77] generics_0.1.3 htmlwidgets_1.6.2
## [79] httr_1.4.6 RCircos_1.2.2
## [81] graphite_1.46.0 pkgconfig_2.0.3
## [83] gtable_0.3.3 blob_1.2.4
## [85] XVector_0.40.0 htmltools_0.5.5
## [87] fgsea_1.26.0 clue_0.3-64
## [89] scales_1.2.1 osfr_0.2.9
## [91] png_0.1-8 snakecase_0.11.0
## [93] knitr_1.42 rstudioapi_0.14
## [95] tzdb_0.3.0 rjson_0.2.21
## [97] nlme_3.1-162 curl_5.0.0
## [99] cachem_1.0.8 zoo_1.8-12
## [101] GlobalOptions_0.1.2 BiocVersion_3.17.1
## [103] parallel_4.3.0 pillar_1.9.0
## [105] vctrs_0.6.2 promises_1.2.0.1
## [107] dbplyr_2.3.2 xtable_1.8-4
## [109] cluster_2.1.4 Rgraphviz_2.44.0
## [111] evaluate_0.21 magick_2.7.4
## [113] mvtnorm_1.1-3 cli_3.6.1
## [115] compiler_4.3.0 rlang_1.1.1
## [117] crayon_1.5.2 mutoss_0.1-13
## [119] fs_1.6.2 stringi_1.7.12
## [121] viridisLite_0.4.2 BiocParallel_1.34.1
## [123] munsell_0.5.0 Biostrings_2.68.0
## [125] Matrix_1.5-4 hms_1.1.3
## [127] bit64_4.0.5 KEGGREST_1.40.0
## [129] shiny_1.7.4 interactiveDisplayBase_1.38.0
## [131] AnnotationHub_3.8.0 rbibutils_2.2.13
## [133] memoise_2.0.1 bslib_0.4.2
## [135] fastmatch_1.1-3 bit_4.0.5
## [137] ape_5.7-1