weeks post-ATI week PTX .y. group1 group2 n1 n2 statistic p p.adj p.adj.signif -76 -64 VL aIL-10 aIL-10+aPD-1 9 10 28 0.182 0.273 ns -76 -64 VL aIL-10 Control 9 8 20 0.139 0.273 ns -76 -64 VL aIL-10+aPD-1 Control 10 8 38 0.897 0.897 ns -75 -63 VL aIL-10 aIL-10+aPD-1 9 10 35 0.447 0.722 ns -75 -63 VL aIL-10 Control 9 8 28 0.481 0.722 ns -75 -63 VL aIL-10+aPD-1 Control 10 8 37 0.829 0.829 ns -73 -61 VL aIL-10 aIL-10+aPD-1 9 10 51 0.661 0.829 ns -73 -61 VL aIL-10 Control 9 8 40 0.743 0.829 ns -73 -61 VL aIL-10+aPD-1 Control 10 8 37 0.829 0.829 ns -71 -59 VL aIL-10 aIL-10+aPD-1 9 10 46 0.968 0.968 ns -71 -59 VL aIL-10 Control 9 8 37 0.963 0.968 ns -71 -59 VL aIL-10+aPD-1 Control 10 8 41 0.965 0.968 ns -69 -57 VL aIL-10 aIL-10+aPD-1 9 10 42.5 0.87 0.962 ns -69 -57 VL aIL-10 Control 9 8 37 0.962 0.962 ns -69 -57 VL aIL-10+aPD-1 Control 10 8 42 0.897 0.962 ns -65 -53 VL aIL-10 aIL-10+aPD-1 9 10 45.5 1 1 ns -65 -53 VL aIL-10 Control 9 8 33 0.81 1 ns -65 -53 VL aIL-10+aPD-1 Control 10 8 33.5 0.594 1 ns -61 -49 VL aIL-10 aIL-10+aPD-1 9 10 49 0.769 0.807 ns -61 -49 VL aIL-10 Control 9 8 33 0.807 0.807 ns -61 -49 VL aIL-10+aPD-1 Control 10 8 34 0.618 0.807 ns -58 -46 VL aIL-10 aIL-10+aPD-1 4 5 12.5 0.62 1 ns -58 -46 VL aIL-10 Control 4 4 8.5 1 1 ns -58 -46 VL aIL-10+aPD-1 Control 5 4 10.5 1 1 ns -57 -45 VL aIL-10 aIL-10+aPD-1 5 5 13.5 0.911 1 ns -57 -45 VL aIL-10 Control 5 4 9.5 1 1 ns -57 -45 VL aIL-10+aPD-1 Control 5 4 8.5 0.798 1 ns -54 -42 VL aIL-10 aIL-10+aPD-1 4 5 11 0.9 1 ns -54 -42 VL aIL-10 Control 4 4 8 1 1 ns -54 -42 VL aIL-10+aPD-1 Control 5 4 12 0.702 1 ns -53 -41 VL aIL-10 aIL-10+aPD-1 5 5 9.5 0.519 0.519 ns -53 -41 VL aIL-10 Control 5 4 3 0.081 0.243 ns -53 -41 VL aIL-10+aPD-1 Control 5 4 6.5 0.443 0.519 ns -50 -38 VL aIL-10 aIL-10+aPD-1 4 5 8.5 0.797 0.869 ns -50 -38 VL aIL-10 Control 4 4 9 0.869 0.869 ns -50 -38 VL aIL-10+aPD-1 Control 5 4 12 0.687 0.869 ns -49 -37 VL aIL-10 aIL-10+aPD-1 5 5 14 0.797 0.892 ns -49 -37 VL aIL-10 Control 5 4 9 0.892 0.892 ns -49 -37 VL aIL-10+aPD-1 Control 5 4 8 0.662 0.892 ns -46 -34 VL aIL-10 aIL-10+aPD-1 4 5 9.5 1 1 ns -46 -34 VL aIL-10 Control 4 4 7 0.882 1 ns -46 -34 VL aIL-10+aPD-1 Control 5 4 10.5 1 1 ns -45 -33 VL aIL-10 aIL-10+aPD-1 5 5 9.5 0.519 0.519 ns -42 -30 VL aIL-10 aIL-10+aPD-1 4 5 13 0.467 0.867 ns -42 -30 VL aIL-10 Control 4 4 10 0.62 0.867 ns -42 -30 VL aIL-10+aPD-1 Control 5 4 9 0.867 0.867 ns -41 -29 VL aIL-10 aIL-10+aPD-1 5 5 14 0.796 0.796 ns -41 -29 VL aIL-10 Control 5 4 5 0.252 0.378 ns -41 -29 VL aIL-10+aPD-1 Control 5 4 4 0.157 0.378 ns -38 -26 VL aIL-10 aIL-10+aPD-1 9 10 41.5 0.793 0.818 ns -38 -26 VL aIL-10 Control 9 8 27.5 0.415 0.818 ns -38 -26 VL aIL-10+aPD-1 Control 10 8 37 0.818 0.818 ns -34 -22 VL aIL-10 aIL-10+aPD-1 9 10 54.5 0.302 0.678 ns -34 -22 VL aIL-10 Control 9 8 38 0.857 0.857 ns -34 -22 VL aIL-10+aPD-1 Control 10 8 34 0.452 0.678 ns -30 -18 VL aIL-10 aIL-10+aPD-1 9 10 34 0.267 0.772 ns -30 -18 VL aIL-10 Control 9 8 31 0.515 0.772 ns -30 -18 VL aIL-10+aPD-1 Control 10 8 42 0.873 0.873 ns -26 -14 VL aIL-10+aPD-1 Control 10 8 34 0.45 0.45 ns -13 -1 VL aIL-10 aIL-10+aPD-1 9 10 42 0.748 0.748 ns -11 1 VL aIL-10 aIL-10+aPD-1 9 10 42 0.748 1 ns -11 1 VL aIL-10 Control 9 8 36 1 1 ns -11 1 VL aIL-10+aPD-1 Control 10 8 43.5 0.681 1 ns -7 5 VL aIL-10 aIL-10+aPD-1 9 10 40.5 0.671 0.948 ns -7 5 VL aIL-10 Control 9 8 37 0.948 0.948 ns -7 5 VL aIL-10+aPD-1 Control 10 8 45 0.612 0.948 ns -5 7 VL aIL-10 aIL-10+aPD-1 9 10 51 0.479 0.871 ns -5 7 VL aIL-10 Control 9 8 39.5 0.664 0.871 ns -5 7 VL aIL-10+aPD-1 Control 10 8 38.5 0.871 0.871 ns -3 9 VL aIL-10 aIL-10+aPD-1 9 10 41.5 0.699 1 ns -3 9 VL aIL-10 Control 9 8 35.5 1 1 ns -3 9 VL aIL-10+aPD-1 Control 10 8 42.5 0.784 1 ns 1 13 VL aIL-10 aIL-10+aPD-1 9 10 54 0.452 0.678 ns 1 13 VL aIL-10 Control 9 8 32 0.727 0.727 ns 1 13 VL aIL-10+aPD-1 Control 10 8 27 0.234 0.678 ns 2 14 VL aIL-10 aIL-10+aPD-1 9 10 38.5 0.623 0.623 ns 2 14 VL aIL-10 Control 9 8 16 0.059 0.178 ns 2 14 VL aIL-10+aPD-1 Control 10 8 23.5 0.155 0.232 ns 3 15 VL aIL-10 aIL-10+aPD-1 9 10 53 0.549 0.549 ns 3 15 VL aIL-10 Control 9 8 18 0.092 0.138 ns 3 15 VL aIL-10+aPD-1 Control 10 8 15 0.029 0.088 ns 4 16 VL aIL-10 aIL-10+aPD-1 9 10 58 0.306 0.306 ns 4 16 VL aIL-10 Control 9 8 21 0.162 0.243 ns 4 16 VL aIL-10+aPD-1 Control 10 8 10 0.009 0.026 * 5 17 VL aIL-10 aIL-10+aPD-1 9 10 61 0.201 0.302 ns 5 17 VL aIL-10 Control 9 8 28.5 0.5 0.5 ns 5 17 VL aIL-10+aPD-1 Control 10 8 14 0.023 0.069 ns 6 18 VL aIL-10 aIL-10+aPD-1 9 10 62.5 0.163 0.244 ns 6 18 VL aIL-10 Control 9 8 33 0.815 0.815 ns 6 18 VL aIL-10+aPD-1 Control 10 8 16 0.036 0.109 ns 7 19 VL aIL-10 aIL-10+aPD-1 9 10 68.5 0.059 0.088 ns 7 19 VL aIL-10 Control 9 8 38 0.885 0.885 ns 7 19 VL aIL-10+aPD-1 Control 10 8 8.5 0.006 0.017 * 8 20 VL aIL-10 aIL-10+aPD-1 9 10 62.5 0.163 0.244 ns 8 20 VL aIL-10 Control 9 8 27.5 0.441 0.441 ns 8 20 VL aIL-10+aPD-1 Control 10 8 12 0.014 0.043 * 9 21 VL aIL-10 aIL-10+aPD-1 9 10 65.5 0.101 0.152 ns 9 21 VL aIL-10 Control 9 8 33 0.815 0.815 ns 9 21 VL aIL-10+aPD-1 Control 10 8 11 0.011 0.034 * 10 22 VL aIL-10 aIL-10+aPD-1 9 10 64 0.129 0.194 ns 10 22 VL aIL-10 Control 9 8 30 0.596 0.596 ns 10 22 VL aIL-10+aPD-1 Control 10 8 15 0.029 0.087 ns 11 23 VL aIL-10 aIL-10+aPD-1 9 10 60 0.234 0.351 ns 11 23 VL aIL-10 Control 9 8 32 0.736 0.736 ns 11 23 VL aIL-10+aPD-1 Control 10 8 14 0.023 0.07 ns 12 24 VL aIL-10 aIL-10+aPD-1 9 10 60 0.234 0.351 ns 12 24 VL aIL-10 Control 9 8 32 0.736 0.736 ns 12 24 VL aIL-10+aPD-1 Control 10 8 16.5 0.041 0.122 ns 13 25 VL aIL-10 aIL-10+aPD-1 9 10 67 0.075 0.112 ns 13 25 VL aIL-10 Control 9 8 33 0.81 0.81 ns 13 25 VL aIL-10+aPD-1 Control 10 8 16 0.036 0.107 ns 14 26 VL aIL-10 aIL-10+aPD-1 9 10 68.5 0.058 0.087 ns 14 26 VL aIL-10 Control 9 8 33 0.815 0.815 ns 14 26 VL aIL-10+aPD-1 Control 10 8 13 0.018 0.054 ns 16 28 VL aIL-10 aIL-10+aPD-1 9 10 69.5 0.049 0.073 ns 16 28 VL aIL-10 Control 9 8 33.5 0.847 0.847 ns 16 28 VL aIL-10+aPD-1 Control 10 8 12 0.014 0.042 * 18 30 VL aIL-10 aIL-10+aPD-1 9 10 71.5 0.031 0.047 * 18 30 VL aIL-10 Control 9 8 33 0.815 0.815 ns 18 30 VL aIL-10+aPD-1 Control 10 8 14 0.022 0.047 * 20 32 VL aIL-10 aIL-10+aPD-1 9 10 70 0.045 0.067 ns 20 32 VL aIL-10 Control 9 8 33.5 0.847 0.847 ns 20 32 VL aIL-10+aPD-1 Control 10 8 17 0.045 0.067 ns 22 34 VL aIL-10 aIL-10+aPD-1 9 9 62.5 0.057 0.086 ns 22 34 VL aIL-10 Control 9 8 32.5 0.773 0.773 ns 22 34 VL aIL-10+aPD-1 Control 9 8 14.5 0.043 0.086 ns 24 36 VL aIL-10 aIL-10+aPD-1 9 9 56 0.185 0.277 ns 24 36 VL aIL-10 Control 9 8 30 0.596 0.596 ns 24 36 VL aIL-10+aPD-1 Control 9 8 17 0.075 0.225 ns