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[" Supplementaey Table S1. Basic characteristics of the included studies"]
["Study","Treatment","Sample","Age","Initial systolic pressure (mmHg)","Initial diastolic pressure (mmHg)","Implementation details","Diagnosis of hypertension"]
["Nutrition 1992 ","Calcium",579,"23.7±5.5","Mean blood pressure","Mean blood pressure","Calcium: 642±448 mg/day","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",588,null,"104 mmHg","66 mmHg"]
["Barakat 2016 ","Exercise",382,"31.6±4.2","113.5±11.8","68.0±8.4","Exercise: trained 3 days/week (50-55 min per session), from weeks 9–11 of pregnancy, to the end of the third trimester (weeks 38–39).  The intervention involved aerobic exercise, aerobic dance, muscular strength, and flexibility, and met the standards of the American Congress of Obstetricians and Gynecologists","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Usual-care",383,"31.8±4.5","113.9±13.8","67.5±10.2"]
["Belizán 1991 ","Calcium",593,"23.7±5.5","103.8±9.5","66.2±8.8","The mean calcium content of the tablets was 470±12 mg, and the placebo tablets was 6.7±0.1 mg. Each woman was instructed and continually encouraged to take four tab lets per day, for a total daily calcium supplementation of 2000 mg in the calcium group.","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",601,"23.7±5.7","104.1±9.4","66.7±8.5"]
["Byaruhanga 1998 ","Aspirin",113,"27.3±5.1","125±18.3","82±17.2","The dose of aspirin was 75 mg, The subjects were reviewed and monitored monthly up to 28 weeks, fortnightly up to 36 weeks and weekly up to delivery","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",117,"28.1±5.0","127±21.6","81±15.0"]
["Caritis 1998 ","Aspirin",1254,"26±6","114±14","69±11","Aspirin: at least five tablets of 60 mg once daily, and Visits usually occurred every 4 weeks until the 28th week of pregnancy, every 2 weeks from then until the 36th week, and then weekly until delivery","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",1249,"25±6","112±11","66±10"]
["Caspi 1994 ","Aspirin",24,"28.8±4.4","—","—","Each patient participating in the trial received a coded package with 30 tablets containing 100 mg of aspirin or a matching placebo, with visits every 2 to 3 week until 34 weeks","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",23,"27.8±4.5"]
["Chappell 1999 ","Vitamins E",79,"28.9±6.4","112±15","67±11","Capsules containing 400 IU natural-source vitamin E and placebo capsules of identical appearance (containing soya-bean oil) were provided","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",81,"29.8±5.6","110±12","68±10"]
["Chen 2019 ","Folic acid",5923,"Average","—","—","Women were randomly assigned to the FA group (400 mg folic acid), IFA group (400 mg folic acid and 30 mg iron), or MMN group (400 mg folic acid, 30 mg iron, and 13 additional vitamins and minerals) and were advised to consume one pill every day from enrollment to delivery","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Multiple micronutrient",5914,"maternal age"]
[{"$nulls":3},"23.6±2.8"]
["Cheng 1991","Aspirin",50,"—","—","—","Low dose Aspirin (50 mg/day) or placebo was given consecutively from the 28th weeks of gestation","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",50]
["Chiaffarino 2004 ","Aspirin",16,"—","—","—","Randomisation list to treatment with 100 mg ASA daily until delivery, or no treatment.","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Usual-care",19]
["Crowther 1999 ","Calcium",227,"25.1±5.3","115.8±12.2","67.8±9.4","Women were asked to take 3 tablets daily orally, equivalent to 1.8g calcium or placebo from the twentieth week of gestation","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",229,"24.3±5.4","115.8±11.7","68.6±8.1"]
["Almeida 1992 ","Fish oil",50,"Ages ranged from 14-40 years","—","—","The patients in Groups of Fish oil and Placebo received, at the beginning of the supplementation period, 240 capsules (8 per day) and those in group 3 received 60 Magnesium tablets a month (2 tablets per day of 500mg).","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Magnesium",50]
[null,"Placebo",50]
["Haapsamo 2010 ","Aspirin",52,"31.4±3.4","—","—","Pregnant women were randomized to receive 100 mg aspirin or placebo daily, starting on the first day of gonadotrophin stimulation continued the medication until delivery.","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",55,"31.3±4.2"]
["Hauth 1993","Aspirin",302,"20.3±2.6","—","—","The patients were randomized to receive a daily 60-mg capsule of aspirin or an identical-appearing placebo containing a lactose filler.","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",302,"20.4±2.7"]
["Herrera 2005 ","Calcium",24,"≤ 19 years or older than 35 years","—","85 mm Hg or higher","The study group received a daily oral dose of 1484 mg of calcium carbonate, i.e., 600 mg of elemental calcium, and 450 mg of CLA. The control group received placebo pills containing 600 mg of lactose and 450 mg of starch","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",24]
["Hofmeyr 2019 ","Calcium",296,"29.4±5.4","126.0±17.3","81.2±12.8","Calcium and placebo tablets were packed in identical 12-week treatment bottles, each containing 84 tablets.  The calcium group received one chewable tablet containing 500 mg elemental calcium (as calcium carbonate) daily from prepregnancy randomisation until 20 weeks gestation","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",283,"29.2±5.1","126.1±18.8","81.7±13.7"]
["Hofmeyr 2008 ","Calcium",317,"22.0±3.7","111±11","59.0±11.0","The median dietary calcium intake of pregnant women to be less than 50% of the recommended daily allowance (1200 mg). The calcium supplement was 1500 mg/day given as carbonate orally. The placebo tablets were identical in form, color, and taste.","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",326,"22.1±3.7","110±10.7","59.5±10.5"]
["Khoram 2019 ","Walking",36,"31.91±4.62","—","—","These women were asked to have an average moderate walk for 20–30 min each week from 14 to 34 weeks of the pregnancy, four times a week so that they can talk when walking","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Usual-care",36,"31.00±5.29"]
["Kiondo 2014 ","Vitamin-C",415,"—","113.9±12.8","67.5±11.4","Vitamin arm: taking a tablet of 1000 mg of vitamin C (as ascorbic acid) daily until they delivered.   Placebo arm: taking a placebo tablet daily which was identical to the vitamin tablets in shape, color and size","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",418,null,"114.9±14.1","68.1±11.2"]
["Kyle 1995 ","Aspirin",44,"28.7±4.8","115.0±11.8","68.2±7.8","woman placebo tablet, the woman was advised to take one tablet daily until 38 weeks","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",36,"27.3±4.5","116.8±12.4","68.0±7.9"]
["Levine 1997 ","Calcium",2205,"21±4","106.4±8.7","59.6±8.0","Calcium tablets: 500 mg of elemental calcium as calcium carbonate. Fifty tablets each of calcium and placebo were selected, and the mean calcium content of the calcium tablets was 485 mg","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",2294,"21±4","106.6±8.8","59.8±7.6"]
["Li 1997 ","Magnesium",51,"The average age ranges from 24 to 35","Mean arterial pressure ≥ 11.3 kPa","Mean arterial pressure ≥ 11.3 kPa","Low-dose magnesium gluconate (3 g/day) or placebo was given from the 28th week of gestation to delivery consecutively","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",51]
["Li 2000 ","Calcium",44,"—","Mean arterial pressure ≥ 11.3 kPa","Mean arterial pressure ≥ 11.3 kPa","From 20 to 24 weeks of gestation, different oral doses of calcite-D (600 mg, 120 mg) and control groups were used in this prospective study","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Usual-care",44]
["Lin 2010 ","Vitamins C",1607,"—","—","—","Vitamin E (VE) and Salvia Miltiorrhiza L (SML): triple per day and 0.3 g per time; VE, triple per day and 30 mg per time; SML, triple per day and 2 tables per time","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Usual-care",3207]
["Lin 2022 ","Aspirin",464,"32.88±4.62","128.64±16.26","82.12±12.66","Participants were randomized in a 1:1 allocation ratio.  They were assigned a randomization code, which determined the women who received 100 mg of aspirin daily and those who did not","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Usual-care",434,"32.78±4.46","128.05±16.11","81.60±12.18"]
["Liu 2016 ","Aspirin",50,"26.6±5.2","103.6±24.7","72.6±16.9","Aspirin group were given 100 mg/d aspirin which was orally intaken before sleep until labor.  Patients in the placebo group were given 100 mg/d drug with basically the same characteristics, color and tastes","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",48,"25.3±5.8","102.8±25.5","70.5±15.7"]
["Liu 2021 ","Folic acid",2902,"23.5±3.0","—","—","Three groups to receive different daily supplements as follows: FA (0.4 mg); IFA, FA (0.4 mg) plus iron (30 mg); and MMN (UNIMMAP supplement has the same amount of iron and FA as the IFA)","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Multiple micronutrient",2898,"25.3±5.9"]
["López 1989 ","Calcium",49,"18.7±2.7","—","—","Calcium group: rcccived four tablets daily, each tablet containing 500 mg elemental calcium. Each woman received a total of 2000mg elemental calcium daily, beginning after 23 weeks gestation and continuing until delivery.","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",43,"18.2±2.2"]
["Mahdy 2013 ","vitamin E",151,"—","—","—","were randomized to receive either oral tocotrienol-rich fraction of palm oil 100 mg daily or placebo, from early second trimester until delivery","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",148]
["McParland 1990 ","Aspirin",48,"25.6±4.2","106±10","68±7","Participants were randomly allocated to groups receiving 75 mg aspirin daily or an identical placebo, the tablets were dispensed by the pharmacist in serially numbered bottles containing 16 weeks' supply (112 tablets)","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",52,"26.5±5.1","110±12","69±8"]
["Niromanesh 2001 ","Calcium",15,"23.8±4.7","—","—","The treatment regimen was a daily intake of 2 g of elemental calcium as four tablets of 500 mg taken orally every 6","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",15,"22.5±4.9"]
["Odibo 2015 ","Aspirin",16,"30.0±5.0","—","—","Women meeting the inclusion criteria were randomized to receive daily 81 mg aspirin or a placebo pill from 11 + 0 to 13 + 6 weeks until 37 weeks or delivery, whichever occurred first","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",14,"31.6±6.1"]
["Purwar 1996 ","Calcium",103,"21.78±2.31","102.00±10.80","62.00±6.50","The calcium supplemented group received 4 tablets of calcium per day after 20 weeks of gestation until delivery. Each of these tablets provided 500 mg of elemental calcium, for a total of 2 g per day","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",93,"22.08±2.87","104.10±9.20","64.70±7.80"]
["Rakhshani 2012 ","Yoga",29,"27.77±5.15","109±13.54","67.62±9.08","The yoga group received standard care plus a one-hour yoga session three times a week from the beginning of the 13th week to the end of the 28th week of gestation (a total of 28 sessions), while the control group received standard care plus walking for half an hour mornings and evenings (the routine antenatal exercise offered by the hospital) during the same period.","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Walking",30,"27.21±5.20","104±8.28","65.59±7.94"]
["Rayman 2014 ","Selenium",115,"30.35±4.55","—","—","60 mg/d of Se, as Se-enriched yeast, or placebo yeast, 60 mg/d is the recommended intake for UK women. The treatment period was from randomisation (12 up to a maximum of 14 weeks) until delivery","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",114,"31.11±3.75"]
["Rogers 1999 ","Calcium",114,"27.1±3.8","—","67.0±5.4","The dose of aspirin prescribed was 80 mg/day starting at 22 weeks of gestation and given for the duration of pregnancy.  Calcium supplementation was prescribed in dosages of 600 mg/day from 22 to 32 weeks of gestation and 1200 mg/day in divided doses from 32 weeks' gestation until delivery.","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Aspirin",118,"27.0±3.9",null,"68.1±6.1"]
[null,"Usual-care",75,"27.7±4.0",null,"66.9±5.9"]
["Rotchell 1998 ","Aspirin",1819,"24% were younger than 20 years of age","99% were lower than 90 mmHg","—","Women were assigned to either 75 mg controlled release aspirin or a matching placebo.   Each treatment pack contained seven one-month calendar sheets.  Women were instructed to take one tablet daily until delivery","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",1822]
["Sanchez 1994 ","Calcium",29,"—","—","—","women were given 2 g/day of oral elemental calcium or placebo, the tablets were dispensed by the hospital pharmacy in serially numbered computerized pill bottles so as to assess compliance","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",34]
["Schiff 1990 ","Aspirin",23,"26.7±2.9","—","—","Patients in one group received a daily pill consisting of 100 mg acetylsalicylic acid, whereas those in the other group received a daily placebo pill consisting of 100 mg of starch and 45 mg of lactose","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",24,"27.2±3.1"]
["Schiff 1989 ","Aspirin",34,"27.1±6.1","—","—","Aspirin pills consisting of 100 mg of acetylsalicylic acid 30 mg of starch, and 0.09 mg of colloidal silicon dioxide, and the control group received placebo pills consisting of 100 mg of starch, 45 mg of lactose 0.1 mg of colloidal silicon dioxide, 2 mg of talc 0.4 mg of gelatinand 0.8 mg ofcalcium stearate","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",31,"27.6±5.7"]
["Sibai 1993 ","Aspirin",1485,"20±4","105±11","61±9","women found to be compliant on this test were as- signed randomly to receive aspirin (60mg plus starch) or placebo (lactose plus starch)","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",1500,"21±5","106±11","61±9"]
["Subtil 2003 ","Aspirin",1632,"24.7±4.4","119.2±11.5","67.6±9.4","women who received 100 mg aspirin daily to a control group taking a placebo, each packet contained 100.0 mg of acetylsalicylic acid","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",1637,"24.6±4.4","118.5±11.5","67.3±9.3"]
["Tewari 1997 ","Aspirin",25,"—","—","—","The study group comprised 25 women who received 50 mg aspirin daily from day of positive ROT till 37 weeks of pregnancy. Other 25 women served as control","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",25]
["Vanbuul 1997 ","Sodium",119,"28.1 (19.8-41.3)","—","—","A sodium-restricted diet containing 20 mmol of sodium/day. The diet was used between week 14 of pregnancy and delivery","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",132,"28.3 (18.1-40.5)"]
["Villar 2006 ","Calcium",4151,"22.6±4.4","105.0±10.7","60.8±9.5","Women were assigned randomly to receive calcium-containing tablets (1.5 g/d) or placebo, from enrollment to delivery","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",4161,"22.7±4.4","105.1±10.9","60.8±9.5"]
["Wallenburg 1986 ","Aspirin",23,"23 (17-38)","—","75 70-80)","Each patient received a coded package with eighty tablets containing 60 mg of aspirin, or matching placebo, according to a randomisation list. Patients were told to take one tablet daily at breakfast until delivery","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Placebo",23,"25 (19-36)",null,"70 (60-80)"]
["Wang 2017 ","Exercise",150,"32.14±4.57","—","—","The intervention was initiated within 3 days of randomization and continued to the end of the third trimester (weeks 36-37), each exercise session consisted of stationary cycling for 30 minutes, beginning with a 5-minute warm-up at low intensity","diastolic BP ≥ 90 mm Hg; systolic BP ≥140 mm Hg"]
[null,"Usual-care",150,"32.50±4.91"]

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[" Supplementary Table S2. The results of network meta-analysis"]
["Yoga","5.02 (1.10,22.80)","4.37 (0.63,30.35)","7.08 (1.27,39.40)","9.85 (1.92,50.55)","8.72 (1.25,60.74)","4.61 (0.58,36.44)","8.94 (1.63,49.10)","6.44 (0.72,57.28)","9.74 (1.22,78.00)","7.64 (0.89,65.28)","22.71 (2.52,204.88)","6.30 (1.15,34.41)","7.05 (1.30,38.15)"]
["0.20 (0.04,0.91)","Walking","0.87 (0.26,2.92)","1.41 (0.63,3.17)","1.96 (1.06,3.65)","1.74 (0.52,5.85)","0.92 (0.22,3.76)","1.78 (0.82,3.89)","1.28 (0.27,6.21)","1.94 (0.47,8.09)","1.52 (0.33,6.96)","4.53 (0.92,22.32)","1.26 (0.58,2.71)","1.40 (0.66,2.97)"]
["0.23 (0.03,1.59)","1.15 (0.34,3.85)","Vitamin-E","1.62 (0.55,4.74)","2.25 (0.80,6.30)","2.00 (0.54,7.40)","1.05 (0.24,4.69)","2.05 (0.81,5.15)","1.47 (0.25,8.71)","2.23 (0.49,10.09)","1.75 (0.31,9.83)","5.20 (0.99,27.33)","1.44 (0.55,3.79)","1.61 (0.61,4.25)"]
["0.14 (0.03,0.79)","0.71 (0.32,1.59)","0.62 (0.21,1.81)","Vitamin-C","1.39 (0.83,2.34)","1.23 (0.42,3.63)","0.65 (0.18,2.38)","1.26 (0.73,2.19)","0.91 (0.20,4.24)","1.38 (0.37,5.12)","1.08 (0.25,4.75)","3.21 (0.72,14.22)","0.89 (0.50,1.60)","1.00 (0.56,1.77)"]
["0.10 (0.02,0.52)","0.51 (0.27,0.95)","0.44 (0.16,1.24)","0.72 (0.43,1.21)","Usual-care","0.89 (0.31,2.49)","0.47 (0.13,1.65)","0.91 (0.58,1.43)","0.65 (0.15,2.79)","0.99 (0.28,3.55)","0.78 (0.19,3.11)","2.31 (0.54,9.90)","0.64 (0.39,1.04)","0.72 (0.45,1.14)"]
["0.11 (0.02,0.80)","0.58 (0.17,1.94)","0.50 (0.14,1.86)","0.81 (0.28,2.39)","1.13 (0.40,3.18)","Sodium","0.53 (0.12,2.36)","1.02 (0.40,2.60)","0.74 (0.12,4.38)","1.12 (0.25,5.08)","0.88 (0.16,4.95)","2.60 (0.49,13.75)","0.72 (0.27,1.91)","0.81 (0.30,2.14)"]
["0.22 (0.03,1.72)","1.09 (0.27,4.45)","0.95 (0.21,4.22)","1.54 (0.42,5.60)","2.14 (0.61,7.51)","1.89 (0.42,8.45)","Selenium","1.94 (0.60,6.26)","1.40 (0.21,9.52)","2.11 (0.40,11.27)","1.66 (0.25,10.78)","4.93 (0.81,30.13)","1.37 (0.41,4.57)","1.53 (0.46,5.12)"]
["0.11 (0.02,0.61)","0.56 (0.26,1.22)","0.49 (0.19,1.23)","0.79 (0.46,1.37)","1.10 (0.70,1.73)","0.98 (0.39,2.47)","0.52 (0.16,1.66)","Placebo","0.72 (0.16,3.29)","1.09 (0.33,3.60)","0.85 (0.20,3.68)","2.54 (0.64,10.10)","0.71 (0.53,0.94)","0.79 (0.59,1.06)"]
["0.16 (0.02,1.38)","0.78 (0.16,3.76)","0.68 (0.11,4.01)","1.10 (0.24,5.12)","1.53 (0.36,6.50)","1.35 (0.23,8.03)","0.72 (0.11,4.87)","1.39 (0.30,6.33)","Multiple-micronutrient","1.51 (0.22,10.43)","1.19 (0.78,1.80)","3.52 (0.45,27.49)","0.98 (0.21,4.51)","1.09 (0.24,5.00)"]
["0.10 (0.01,0.82)","0.52 (0.12,2.15)","0.45 (0.10,2.03)","0.73 (0.20,2.71)","1.01 (0.28,3.63)","0.90 (0.20,4.07)","0.47 (0.09,2.52)","0.92 (0.28,3.03)","0.66 (0.10,4.57)","Magnesium","0.78 (0.12,5.18)","2.33 (0.79,6.84)","0.65 (0.19,2.21)","0.72 (0.21,2.48)"]
["0.13 (0.02,1.12)","0.66 (0.14,3.00)","0.57 (0.10,3.22)","0.93 (0.21,4.08)","1.29 (0.32,5.16)","1.14 (0.20,6.45)","0.60 (0.09,3.92)","1.17 (0.27,5.04)","0.84 (0.56,1.28)","1.27 (0.19,8.41)","Folic-acid","2.97 (0.40,22.22)","0.83 (0.19,3.59)","0.92 (0.21,3.98)"]
["0.04 (0.00,0.40)","0.22 (0.04,1.09)","0.19 (0.04,1.01)","0.31 (0.07,1.38)","0.43 (0.10,1.86)","0.38 (0.07,2.03)","0.20 (0.03,1.24)","0.39 (0.10,1.56)","0.28 (0.04,2.21)","0.43 (0.15,1.26)","0.34 (0.04,2.51)","Fish-oil","0.28 (0.07,1.15)","0.31 (0.07,1.29)"]
["0.16 (0.03,0.87)","0.80 (0.37,1.71)","0.69 (0.26,1.82)","1.12 (0.62,2.02)","1.56 (0.96,2.54)","1.38 (0.52,3.66)","0.73 (0.22,2.44)","1.42 (1.06,1.89)","1.02 (0.22,4.71)","1.55 (0.45,5.28)","1.21 (0.28,5.27)","3.60 (0.87,14.90)","Calcium","1.12 (0.83,1.51)"]
["0.14 (0.03,0.77)","0.71 (0.34,1.51)","0.62 (0.24,1.64)","1.00 (0.56,1.79)","1.40 (0.88,2.22)","1.24 (0.47,3.29)","0.65 (0.20,2.19)","1.27 (0.94,1.71)","0.91 (0.20,4.18)","1.38 (0.40,4.73)","1.08 (0.25,4.68)","3.22 (0.78,13.37)","0.89 (0.66,1.21)","Aspirin"]

{"sheet":"Table S3.","index":2,"n_rows":44,"n_cols":14,"rows_kept":44,"merged":[[0,0,0,5],[1,0,1,6],[1,7,1,8],[1,10,3,10],[2,0,3,0],[2,1,3,1],[2,2,3,2],[2,3,3,3],[2,4,3,4],[2,5,3,5],[2,6,3,6],[2,7,3,7],[2,8,3,8],[2,9,3,9],[4,3,4,4],[4,7,4,8],[22,0,22,6],[22,7,22,8],[22,10,25,10],[23,0,26,0],[23,1,26,1],[23,2,26,2],[23,3,26,3],[23,4,26,4],[23,5,26,5],[23,6,26,6],[23,7,26,7],[23,8,26,8],[23,9,26,9]],"flags":["formulas_cached_only"]}
["   Supplementary Table S3. The evidence findings for direct comparisons"]
["Certainty assessment",{"$nulls":6},"№ of patients",null,"Effect","Certainty"]
["№ of studies","Study design","Risk of bias","Inconsistency","Indirectness","Imprecision","Publication bias","Intervention1","Intervention2","OR with 95% CI"]
[]
["Aspirin vs Calcium"]
[1,"RCT","Serious","Not serious","Not serious","Not serious","Undetected",114,118,"1.12 (0.83,1.51)","Moderate"]
[18,"RCT","Not serious","Not serious","Not serious","Not serious","Undetected",7010,6935,"0.79 (0.59,1.06)","High"]
["Aspirin vs Usual-care"]
[5,"RCT","Not serious","Not serious","Not serious","Very serious","Undetected",944,608,"5.71 (0.53,62.07)","Low"]
["Calcium vs Placebo"]
[12,"RCT","Not serious","Not serious","Not serious","Not serious","Undetected",8095,8190,"0.71 (0.53,0.94)","High"]
["Calcium vs Usual-care"]
[2,"RCT","Serious","Not serious","Not serious","Not serious","Undetected",158,119,"0.64 (0.39,1.04)","Moderate"]
["Fish-oil vs Magnesium"]
[1,"RCT","Serious","Not serious","Not serious","Serious","Undetected",50,50,"2.33 (0.79,6.84)","Low"]
["Fish-oil vs Placebo"]
[1,"RCT","Serious","Not serious","Not serious","Serious","Undetected",50,50,"2.54 (0.64,10.10)","Low"]
["Folic-acid vs Multiple-micronutrient"]
[2,"RCT","Serious","Not serious","Not serious","Not serious","Undetected",8825,8812,"1.19 (0.78,1.80)","Moderate"]
["Folic-acid vs Usual-care"]
[1,"RCT","Serious","Not serious","Not serious","Serious","Undetected",471,79,"0.78 (0.19,3.11)","Low"]
["Magnesium vs Placebo"]
["Certainty assessment",{"$nulls":6},"№ of patients",null,"Effect","Certainty"]
["№ of studies","Study design","Risk of bias","Inconsistency","Indirectness","Imprecision","Publication bias","Intervention1","Intervention2","OR with 95% CI"]
[]
[]
[]
[1,"RCT","Serious","Not serious","Not serious"," Serious","Undetected",51,51,"1.09(0.33,3.60)","Low"]
["Placebo vs Selenium"]
[1,"RCT","Serious","Not serious","Not serious","Serious","Undetected",115,114,"1.94 (0.60,6.26)","Low"]
["Placebo vs Sodium",{"$nulls":12}," "]
[1,"RCT","Serious","Not serious","Not serious","Not serious","Undetected",119,132,"1.02 (0.40,2.60)","Moderate"]
["Placebo vs Vitamin-C"]
[1,"RCT","Serious","Not serious","Not serious","Not serious","Undetected",415,418,"1.26 (0.73,2.19)","Moderate"]
["Placebo vs Vitamin-E"]
[1,"RCT","Serious","Not serious","Not serious","Serious","Undetected",230,229,"2.05 (0.81,5.15)","Low"]
["Placebo vs Vitamin-E"]
[1,"RCT","Serious","Not serious","Not serious","Serious","Undetected",230,229,"2.05 (0.81,5.15)","Low"]
["Usual-care vs Vitamin-C"]
[1,"RCT","Serious","Not serious","Not serious","Not serious","Undetected",1607,3207,"1.39 (0.83,2.34)","Moderate"]
["Usual-care vs Walking"]
[2,"RCT","Serious","Not serious","Not serious","Not serious","Undetected",569,568,"1.96 (1.06,3.65)","Moderate"]
["Walking vs Yoga"]
[1,"RCT","Serious","Not serious","Not serious","Very serious","Undetected",30,29,"5.02 (1.10,22.80)","Very low"]