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["Study of Origin","Sample ID","Protein Change","d","Functional Impact","Mutation Type","Variant Type"]
["Cholangiocarcinoma (ICGC, Cancer Discov 2017)","CCA_FR_4","H167_N173del","OncoKB: Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: NA;Polyphen-2: NA","In_Frame_Del","DEL"]
["Cholangiocarcinoma (ICGC, Cancer Discov 2017)","CCA_JP_167","N549K","OncoKB: Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999","Missense_Mutation","SNP"]
["Cholangiocarcinoma (ICGC, Cancer Discov 2017)","CCA_JP_178","N549S","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.992","Missense_Mutation","SNP"]
["Cholangiocarcinoma (ICGC, Cancer Discov 2017)","CCA_JP_5","Y375C","OncoKB: Oncogenic, level_4, resistance NA;CIViC: Functional: 1;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.967","Missense_Mutation","SNP"]
["Cholangiocarcinoma (ICGC, Cancer Discov 2017)","CCA_JP_79","M640I","OncoKB: Unknown, level NA, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.003","Missense_Mutation","SNP"]
["Cholangiocarcinoma (ICGC, Cancer Discov 2017)","CCA_SG_15","Y375C","OncoKB: Oncogenic, level_4, resistance NA;CIViC: Functional: 1;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.967","Missense_Mutation","SNP"]
["Cholangiocarcinoma (ICGC, Cancer Discov 2017)","CCA_SG_19","F276C","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999","Missense_Mutation","SNP"]
["Cholangiocarcinoma (ICGC, Cancer Discov 2017)","CCA_SG_34","S282_N297del","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: NA;Polyphen-2: NA","In_Frame_Del","DEL"]
["Cholangiocarcinoma (ICGC, Cancer Discov 2017)","CCA_SG_9","Y375C","OncoKB: Oncogenic, level_4, resistance NA;CIViC: Functional: 1;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.967","Missense_Mutation","SNP"]
["Cholangiocarcinoma (ICGC, Cancer Discov 2017)","CCA_TH_10","S252W","OncoKB: Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: probably_damaging, score: 0.999","Missense_Mutation","SNP"]
["Cholangiocarcinoma (ICGC, Cancer Discov 2017)","CCA_TH_50","K161N","OncoKB: Unknown, level NA, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.999","Missense_Mutation","SNP"]
["Cholangiocarcinoma (ICGC, Cancer Discov 2017)","CCA_TH_6","V233del","OncoKB: Unknown, level NA, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: NA;Polyphen-2: NA","In_Frame_Del","DEL"]
["Intrahepatic Cholangiocarcinoma (JHU, Nat Genet 2013)","CHOL07","F276C","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999","Missense_Mutation","SNP"]
["Intrahepatic Cholangiocarcinoma (JHU, Nat Genet 2013)","CHOL09","Y375C","OncoKB: Oncogenic, level_4, resistance NA;CIViC: Functional: 1;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.967","Missense_Mutation","SNP"]
["Intrahepatic Cholangiocarcinoma (JHU, Nat Genet 2013)","CHOL28","H624del","OncoKB: Unknown, level NA, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: NA;Polyphen-2: NA","In_Frame_Del","DEL"]
["Intrahepatic Cholangiocarcinoma (JHU, Nat Genet 2013)","CHOL42","C382R","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: possibly_damaging, score: 0.465","Missense_Mutation","SNP"]
["Cholangiocarcinoma (MSK, Clin Cancer Res 2018)","P-0001638-T01-IM3","I654T","OncoKB: Unknown, level NA, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.889","Missense_Mutation","SNP"]
["Cholangiocarcinoma (MSK, Clin Cancer Res 2018)","P-0009596-T01-IM5","W290R","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999","Missense_Mutation","SNP"]
["Cholangiocarcinoma (MSK, Clin Cancer Res 2018)","P-0012003-T01-IM5","C382R","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: possibly_damaging, score: 0.465","Missense_Mutation","SNP"]
["Intrahepatic Cholangiocarcinoma (MSK, Hepatology 2021)","P-0017971-T01-IM6","C382R","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: possibly_damaging, score: 0.465","Missense_Mutation","SNP"]
["Intrahepatic Cholangiocarcinoma (MSK, 2020)","P-0018110-T01-IM6","V280_K292del","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: NA;Polyphen-2: NA","In_Frame_Del","DEL"]
["Intrahepatic Cholangiocarcinoma (MSK, Hepatology 2021)","P-0023349-T01-IM6","W290C","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: Functional: 1;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999","Missense_Mutation","SNP"]
["Intrahepatic Cholangiocarcinoma (MSK, 2020)","P-0023351-T01-IM6","S372C","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.712","Missense_Mutation","SNP"]
["Intrahepatic Cholangiocarcinoma (MSK, Hepatology 2021)","P-0029803-T01-IM6","W290L","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.998","Missense_Mutation","SNP"]
["Intrahepatic Cholangiocarcinoma (MSK, Hepatology 2021)","P-0029964-T01-IM6","V463Gfs*3","OncoKB: Unknown, level NA, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: NA;Polyphen-2: NA","Frame_Shift_Del","DEL"]
["Intrahepatic Cholangiocarcinoma (MSK, Hepatology 2021)","P-0032563-T01-IM6","H167_N173del","OncoKB: Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: NA;Polyphen-2: NA","In_Frame_Del","DEL"]
["Intrahepatic Cholangiocarcinoma (MSK, Hepatology 2021)","P-0036277-T01-IM6","P286_K292del","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: NA;Polyphen-2: NA","In_Frame_Del","DEL"]
["Intrahepatic Cholangiocarcinoma (MSK, Hepatology 2021)","P-0036980-T01-IM6","C382R","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: possibly_damaging, score: 0.465","Missense_Mutation","SNP"]
["Intrahepatic Cholangiocarcinoma (MSK, 2020)","P-0038153-T01-IM6","C382R","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: possibly_damaging, score: 0.465","Missense_Mutation","SNP"]
["Intrahepatic Cholangiocarcinoma (MSK, Hepatology 2021)","s_C_62YLL6_T001_d","V395D","OncoKB: Unknown, level NA, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.849","Missense_Mutation","SNP"]
["Intrahepatic Cholangiocarcinoma (MSK, 2020)","s_WJ_chol_057_T","F276C","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999","Missense_Mutation","SNP"]
["Intrahepatic Cholangiocarcinoma (MSK, 2020)","s_WJ_chol_070_T","H167_N173del","OncoKB: Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: NA;Polyphen-2: NA","In_Frame_Del","DEL"]
["Intrahepatic Cholangiocarcinoma (MSK, 2020)","s_WJ_chol_070_T","Y561*","OncoKB: Unknown, level NA, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: NA;Polyphen-2: NA","Frame_Shift_Del","DEL"]
["Intrahepatic Cholangiocarcinoma (MSK, 2020)","s_WJ_chol_072_T","V395D","OncoKB: Unknown, level NA, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.849","Missense_Mutation","SNP"]
["Intrahepatic Cholangiocarcinoma (MSK, 2020)","s_WJ_chol_078_T","F276C","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999","Missense_Mutation","SNP"]
["Intrahepatic Cholangiocarcinoma (MSK, 2020)","s_WJ_chol_085_T","A578D","OncoKB: Unknown, level NA, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: possibly_damaging, score: 0.784","Missense_Mutation","SNP"]
["Intrahepatic Cholangiocarcinoma (MSK, 2020)","s_WJ_chol_085_T","A578S","OncoKB: Unknown, level NA, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no","SIFT: impact: tolerated, score: 0.16;Polyphen-2: impact: benign, score: 0.431","Missense_Mutation","SNP"]
["Cholangiocarcinoma (TCGA, Firehose Legacy)","TCGA-W5-AA34-01","F276C","OncoKB: Likely Oncogenic, level_4, resistance NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no","SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999","Missense_Mutation","SNP"]