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["Supplementary Table 3b"]
["Characteristic","Unweighted population (before imputation)",{"$nulls":3},"Unweighted population (after imputation)",{"$nulls":3},"Weighted population"]
[null,"Overall *","ABI *","ENZ *","Difference **","Overall *","ABI *","ENZ *","Difference **","ABI ***","ENZ ***","Difference **"]
[null,"n=242","n=61","n=181",null,"n=12100","n=3050","n=9050",null,"n=3038","n=9078"]
["Age at treatment initiation","75.8 (7.7)","76.4 (7.1)","75.6 (7.9)",0.11,"75.8 (7.6)","76.4 (7.0)","75.6 (7.8)",0.11,"75.6 (7.0)","75.7 (7.8)",-0.01]
["    Missing","1 (0.4)","0 (0)","1 (0.6)"]
["ECOG performance status",{"$nulls":3},0.08,{"$nulls":3},0.08,null,null,-0.04]
[0,"233 (96.3)","58 (95.1)","175 (96.7)",null,"11,650 (96.3)","2,900 (95.1)","8,750 (96.7)",null,96.7,96]
[1,"9 (3.7)","3 (4.9)","6 (3.3)",null,"450 (3.7)","150 (4.9)","300 (3.3)",null,3.3,4]
["Gleason score",{"$nulls":3},0.26,{"$nulls":3},0.22,null,null,0]
[0,"45 (23.4)","7 (15.6)","38 (25.9)",null,"2,918 (24.1)","532 (17.4)","2,386 (26.4)",null,24.8,24.7]
[1,"147 (76.6)","38 (84.4)","109 (74.1)",null,"9,182 (75.9)","2,518 (82.6)","6,664 (73.6)",null,75.2,75.3]
["    Missing","50 (21)","16 (26)","34 (19)"]
["Bone metastasis",{"$nulls":3},0.03,{"$nulls":3},0.01,null,null,0.05]
[0,"97 (42.9)","25 (41.7)","72 (43.4)",null,"5,107 (42.2)","1,273 (41.7)","3,834 (42.4)",null,39.4,41.7]
[1,"129 (57.1)","35 (58.3)","94 (56.6)",null,"6,993 (57.8)","1,777 (58.3)","5,216 (57.6)",null,60.6,58.3]
["    Missing","16 (6.6)","1 (1.6)","15 (8.3)"]
["Lymph node metastasis",{"$nulls":3},0.17,{"$nulls":3},0.17,null,null,0.03]
[0,"169 (75.1)","41 (69.5)","128 (77.1)",null,"9,025 (74.6)","2,104 (69.0)","6,921 (76.5)",null,72.9,74.4]
[1,"56 (24.9)","18 (30.5)","38 (22.9)",null,"3,075 (25.4)","946 (31.0)","2,129 (23.5)",null,27.1,25.6]
["    Missing","17 (7.0)","2 (3.3)","15 (8.3)"]
["Visceral metastasis",{"$nulls":3},0.37,{"$nulls":3},0.36,null,null,0.04]
[0,"200 (88.9)","47 (79.7)","153 (92.2)",null,"10,743 (88.8)","2,427 (79.6)","8,316 (91.9)",null,86.9,88.2]
[1,"25 (11.1)","12 (20.3)","13 (7.8)",null,"1,357 (11.2)","623 (20.4)","734 (8.1)",null,13.1,11.8]
["    Missing","17 (7.0)","2 (3.3)","15 (8.3)"]
["Any metastasis",{"$nulls":3},0.09,{"$nulls":3},0.06,null,null,0.05]
[0,"86 (38.1)","21 (35.0)","65 (39.2)",null,"4,494 (37.1)","1,068 (35.0)","3,426 (37.9)",null,34.2,36.8]
[1,"140 (61.9)","39 (65.0)","101 (60.8)",null,"7,606 (62.9)","1,982 (65.0)","5,624 (62.1)",null,65.8,63.2]
["    Missing","16 (6.6)","1 (1.6)","15 (8.3)"]
["Duration of ADT","30.7 (34.1)","33.9 (40.9)","29.6 (31.7)",0.12,"31.2 (34.9)","35.7 (41.9)","29.7 (32.0)",0.16,"30.3 (36.2)","30.5 (32.4)",-0.01]
["    Missing","26 (11)","8 (13)","18 (9.9)"]
["Baseline hemoglobin","12.3 (1.6)","12.3 (1.7)","12.2 (1.5)",0.05,"12.3 (1.6)","12.3 (1.7)","12.3 (1.5)",0.01,"12.2 (1.6)","12.2 (1.6)",-0.02]
["    Missing","21 (8.7)","11 (18)","10 (5.5)"]
["Baseline alkaline phosphatase","5.6 (0.6)","5.7 (0.5)","5.6 (0.6)",0.12,"5.6 (0.6)","5.7 (0.5)","5.6 (0.6)",0.15,"5.7 (0.5)","5.6 (0.6)",0.05]
["    Missing","29 (12)","12 (20)","17 (9.4)"]
["Baseline lactate dehydrogenase","5.3 (0.3)","5.4 (0.3)","5.3 (0.3)",0.3,"5.3 (0.3)","5.4 (0.3)","5.3 (0.3)",0.31,"5.4 (0.2)","5.3 (0.3)",0.1]
["    Missing","21 (8.7)","10 (16)","11 (6.1)"]
["Baseline C-reactive protein","-1.8 (1.3)","-1.6 (1.3)","-1.9 (1.3)",0.2,"-1.8 (1.3)","-1.6 (1.3)","-1.9 (1.3)",0.24,"-1.8 (1.4)","-1.8 (1.3)",-0.02]
["    Missing","63 (26)","21 (34)","42 (23)"]
[]
["*: Mean (SD); n (%), **: Standardized Mean Difference, ***: Mean (SD); %\n"]

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