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[null,"Table 2. Comparison of variables between baseline and 24 weeks after the administration of luseogliflozin"]
[]
[{"$nulls":3},"Baseline","24 weeks","p-value"]
[null,"Clinical data and blood analysis"]
[null,null,"Body weight, kg","72.2 ± 11.1","71.0 ± 10.6　","  0.01*"]
[null,null,"BMI, kg/m2","26.0 ± 3.3","25.6 ± 3.2","  0.02*"]
[null,null,"Systolic blood pressure, mmHg","125.6 ± 18.1","119.3 ± 16.8","  0.04*"]
[null,null,"HbA1c, %","8.2 ± 1.2","7.4 ± 0.6","<0.01*"]
[null,null,"Cr, mg/dL","1.0 ± 0.5","1.1 ± 0.4",0.41]
[null,null,"eGFR, mL/min/1.73 m2","69.1 ± 30.5","65.0 ± 25.3",0.09]
[null,null,"AST, IU/L","32.9 ± 17.1","27.5 ± 12.1"," 0.04*"]
[null,null,"ALT, IU/L","34.9 ± 22.8","26.2 ± 13.4"," 0.03*"]
[null,null,"γ-GT, IU/L","73.3 ± 58.4","59.9 ± 44.9"," 0.03*"]
[null,null,"HDL-C, mg/dL","45.5 ± 16.4","45.2 ± 14.7",0.87]
[null,null,"LDL-C, mg/dL","90.5 ± 28.2","89.8 ± 26.1",0.89]
[null,null,"TG, mg/dL","204.3 ± 120.7","211.8 ± 148.2",0.95]
[null,null,"NT-proBNP, pg/mL","994.8 ± 147.7","876.3 ± 115.3",0.41]
[null,"Echocardiographic Measurements"]
[null,null,"LAD, mm","42.2 ± 5.7","39.9 ± 6.8　"," 0.01*"]
[null,null,"LVDd, mm","49.5 ± 6.9","47.6 ± 7.6"," 0.01*"]
[null,null,"LVDs, mm","35.8 ± 9.1","33.9 ± 9.8","<0.01*"]
[null,null,"EF, %","53.8 ± 15.4","56.0 ± 16.0",0.07]
[null,null,"E-wave velocity, cm/sec","65.8 ± 21.2","63.3 ± 17.4",0.44]
[null,null,"A-wave velocity, cm/sec","72.1 ± 22.9","75.2 ± 17.0",0.66]
[null,null,"E/A ratio","1.0 ± 0.8","0.9 ± 0.4",0.98]
[null,null,"Deceleration time, msec","196.0 ± 44.4","191.6 ± 62.0",0.64]
[null,null,"e′ velocity, cm/sec","5.8 ± 1.7","5.6 ± 1.7",0.72]
[null,null,"septal E/e′ ratio","12.2 ± 5.1","11.8 ± 5.2",0.69]
[null,"Data are mean ± SD for normally distributed data and median (interquartile range) or n (%) for non-normally distributed data. *p < 0.05"]
[null,"ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; Cr, creatinine; eGFR, estimated glomerular filtration rate; γ-GT, gamma-glutamyl transferase; HbA1c, glycated hemoglobin; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; NT-proBNP, N-terminal pro-B-type natriuretic peptide;"]
[null,"SD, standard deviation; TG, triglycerides; EF, ejection fraction; LAD, left atrial diameter; LVDd, left ventricular diastolic diameter; LVDs, left ventricular systolic diameter; SD, standard deviation"]