193 783 1 ---------------ML---------SQCSWHLLKT-A---KLQLRSLNL---S-LHL-QN-Y--R-------------------------------------------RAFS-K-S-L-PEC--RRKVVVTGXGLVSPLGVGTEFVWKNL-LQGDSGIVALE--G-EE-----------Y-AGIPCKVAACVPRGN----X--E-GQ-F----SEE----MFVSKSETKSMSSATVMAIGAADLAMKDSSWS-P-QSEE-D-R--L----------XAGVAIGMGMVPLEEISDTAA--------------------------LFK-T-KGYNKVSPFFVPKILVNMAAGHISIKYQLKGPNHAVSTACTTGAHAVGDSFRFIASGDADIMLAGGTEACISPLSLAGFARARALSTSFNSSPKMACRPFDSQREGFVMGEGAAVLVLE-----E------YGHAVQRGA-R-IYAEVLGYGLSGDACHITAPNPEGDG-AFRCMSAAIKDS--------GI--KP-EDITYINAHATSTPLGDAAENQAIKRLFKD-----------------------H--------------------------------S--RN--IAVSST-----------------KGATGHLLGAAGAIEAAFTVLSCYHGVLPPTL-NL-EKTE-A-EF--D-L----------N--YVP---------L---T-X----QEWK-------TE--K-RRIALTNSFGFGGTNATLCFSSV-------------- 2 --------------------------------------------------------------------------------------------------------------------------M--KKRVVITGMGVVCPAGANKHTSWKNI-LLGKSFVRKLD--S-DL-----------Y-KNVPSKIAATL-D-----------GL-E----DLP----GTVPKSKVRTMAPSTRLALIAAQEAVDDSKIF-L-ST---V-D-KE----------NIGVSVGVGMVDLEDVCQTA---------------------KA-----LE-I-S-YSKVSPYFVPRILLNMAAGQISMAYGIQGPNHAVSTACATGAHAIGDGFRFIQYGQAKAMICGAAESCISPLSIASFCRIRALSTQ-NDKPELASRPFDVNRDGFVIGEGSAMIILE-----E------LEHAINRNA-H-IYAEVLGYGLSGDASHLTAPPENGQG-ALLAMTRAILDA--------KI--DK-KEITYVNAHATSTPVGDAIELTAIKRLFD-----E------------------H--------------------------------C--NN--VHVSST-----------------KGSHGHLLGSAGNLESIFTILACHEGIIPPTA-NL-TNIC-K-EAK-N-L-------I-----CVS---------K---G-P----IEWKQ----------E-KRIAIKNAFGFGGTNASLCFSNFI-L----------- 3 ---------------------------------------------------MLL-N------VIK------------------------------------------------R-GLHA-TGD--PVRVVITGMGVVSPIGKTLANAWENI-LAGECAVVSLR--E-EE-----------Y-QSLPCKIACKIPDK-----------N-E----FIS----DRFSKSELRTMAPATAIALIATEEALKDARWS-P-RTNE-D-K--L----------NTGVAIGMGMIDLNDVCQTS---------------------ED-----LK-I-KGYKKVSPYFVPRILPNMAAGQVSIKHGLQGPNHSVSTACATGAHSIGDAFRFIQNGDAKVMICGGAESCISPLSIAGFSRLRALATNFNDTPKKASRPFDKDRNGFIMGEGSAIFVLE-----E------LNHAVKRNA-K-IYAEILGYGLSGDASHLTAPSEDGTG-AILSMQRALKNS--------GL--EP-QDIGYINAHATSTPIGDAIESRAIKYVFG-----D------------------H--------------------------------T--NN--IKVSST-----------------KGSHGHLLGAAGNLESVFTVMAIKSENLPPSL-NI-ENVD-E-D-T-K-L-------N-----FVT---------E---P-G----EKWITK----SSD--G-RRIALKNAFGFGGTNATLSSIYDK-TITVSWKFVIWK 4 ------M----------------------------------------------------------------------------------------------------------K-LPTS-LRQ--AVRVVVTGVGAVTPLGVGAGRSWERL-LACHSGIGKLT--G-EE-----------F-EKMPAKVAALVPRGK----E--E-H--Q----FDE----KRFTDAEWRQMSKATAFAVVAAEEALADAQWK-P-NTDK-E-L--H----------NTGVSIGTGMIDLSDVIKTG--------------------------TRLA-E-QGPKIVSPYFIPRILPNMIAGHLAIRYGIKGPNHCVSTACTTGLHSIGDAFMMIQRGLANVMICGSAESSINGLCVAGFCRIRALCTKFNSDPQQASRPFDSERDGFVMGEGAGVLILE-----E------LQHALERNA-R-IYAEVLGYGLSGDGYHLTSPCPDGAG-AKLSMRRALTDA--------GV--KP-EEVGYVNAHATSTKQGDSAETTAIYEIANE----GGK----------------R------------------------------ADK--EQ--PLVSSC-----------------KGAIGHLLGAAGSVETIVTALSCYHGVVPPNR-NL-KKVD-V-PM--N-M-------N-----FSH-----S---E---K-A----TPFPTS--SFT----S-RRVAMKNSFGFWGANATLCLASMD------------Q 5 -----------------------------------------------------------------------------------------------------------------------------MRRVVVTGLGAVTPLGDNVYSTWRS-LLAGKCGIVSF--VM-KGF------------ESIPSKVAGIVSTG-------------F----DEN----RFANSSEKRYLTRGAILALAAAHEAVSDASLD-PTNST--CDP--S----------RMGVSVSSS-VDYQEIYKTGA--------------------------ELY-T-KGYKRVSPFFVPKILTNTVAGVLSERYGLLGPNHSVVTACTTGLHAIGDAASMVSRGVCDVMLAGAGDSTLHPIGLAGFSQCRALSRHFNDSPAEASRPFDSKRDGFVMSEGAGIVILE-----S------LDHAIKRGVEK-IYAEIIGYGMSSDAFHITSPSPEGIG-AINSMKNALSNA--------NL--LP-NRVGYVNAHATSTPIGDKIENEAIKNVFGE----H---------------------------------------------------A--YK--LNISSTK-----------------GATGHLVTAAGVVEAIFCCLAVVNGLIPPT-INL-HEKE--SEF--D-LN------------YTP---------H---A-L----QHWPNI-----GF--K-DRIAITNSFGFGGTNASVILKSYP-SS---------- 6 ----------------------------------------------------------------------------------------------------------------------M-LEK--SRRVVIRGVGLVSCLGVTASENWMHL-LRNDCGIGLLD--G--NC------------AGGPCRIGGRVNNGA----M--ES-R-WRLLEEEQAFLPGVERQIDRRAMSRASVLGMLASHEALKQSGWL-P-QHSGSP-P--RNYSVLNDVSYRAGTYFSTGLEGVAEILSSQA--------------------------RVDR--HGYAGMGAHVLPRTLANMPVAHISRAWGLRGPNMACSTSCASGLHSIGEAFRMIQHGEADMVLAGAAEAPLNPWSLMAFSRIRALTM--ETQAQLASRPFDAARDGFVMAEGAAALVLE-----SWP------SPTSSSA-QPPIAEVLGFGRSADAYSLVSPEPSGDG-AFRSMKAALDDA--------G--IDSLDELGHINCHATSTPVGDVIELSAVARLIAT-YGK-------------------------------------------------RSHS--EP--IHVNSV-----------------KGHLGHCLGAAGAVEAAYSAMAAHHGVCVGNR-NL-ERPI-S-SA--EVVEILKHGSNEEAARSVAQRLFENISFD---S-DRDWAERTENN----G----R-RRLVLTNSFGFGGTNASLLLSNYV------------K 7 ----------------------------------------------------------------------------------------------------------------------M-LEK--SRRVVIRGVGLVSCLGVTVSENWMHL-LRNDCGIGLLD--G--NC------------AGGPCRIGGRVNNGA----M--ES-R-WRLLEEEQAFLPGVERQIDRRAMSRASVLGMLASQEALKQSGWL-P-QHSGSP-P--RNYSVLNDVSYRAGTYFSTGLEGVAEILSSQA--------------------------RVDR--HGYAGMGAHVLPRTLANMPVAHISRAWGLRGPNMACSTSCASGLHSIGEAFRMIQHGEADMVLAGAAEAPLNPWSLMAFSRIRALSM--ETQAQRASRPFDAARDGFVMAEGAAALVLE-----SWP------SPTSSSA-QPPIAEVLGFGRSADAYSLVSPEPSGDG-AFRSMKAALDDA--------G--IDSLDELGHINCHATSTPVGDVIELSAVARLIAT-YGK-------------------------------------------------RSHS--EP--IHVNSV-----------------KGHLGHCLGAAGAVEAAYSAMAAHHGVCVGNR-NL-ERPISS-AE---VVEILKHGSNEKTARSVAQRLFENISFD---S-DRDWAERTENN----G----R-RRLVLTNSFGFGGTNASLLLSNYV------------K 8 ----------------M---------SNCLQNFLKI-T---STRLLCSRL---C-QQL-R-SK--R-------------------------------------------KFFGTV-P-I-SRL--HRRVVITGIGLVTPLGVGTHLVWDRL-IGGESGIVSLV--G-EE-----------Y-KSIPCSVAAYVPRGS----D--E-GQ-F----NEQ----NFVSKSDIKSMSSPTIMAIGAAELAMKDSGWH-P-QSEA-D-Q--V----------ATGVAIGMGMIPLEVVSETAL--------------------------NFQ-T-KGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHG--------------------------------------------------------------------------------------------------DAGHITAPDPEGEG-ALRCMAAALKDA--------GV--QP-EEISYINAHATSTPLGDAAENKAIKHLFKD-----------------------H--------------------------------A--YA--LAVSST-----------------KGATGHLLGAAGAVEAAFTTLACYYQKLPPTL-NL-DCSE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RFIGLTNSFGFGGTNATLCIAGL-------------- 9 ----------------M---------SNCLQNFLKI-T---STRLLCSRL---C-QQL-R-SK--R-------------------------------------------KFFGTV-P-I-SRL--HRRVVITGIGLVTPLGVGTHLVWDRL-IGGESGIVSLV--G-EE-----------Y-KSIPCSVAAYVPRGS----D--E-GQ-F----NEQ----NFVSKSDIKSMSSPTIMAIGAAELAMKDSGWH-P-QSEA-D-Q--V----------ATGVAIGMGMIPLEVVSETAL--------------------------NFQ-T-KGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALST--NSDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------YEHAVQRRA-R-IYAEVLGYGLSGDAGHITAPDPEGEG-ALRCMAAALKDA--------GV--QP-EEISYINAHATSTPLGDAAENKAIKHLFKD-----------------------H--------------------------------A--YA--LAVSST-----------------KGATGHLLGAAGAVEAAFTTLACYYQKLPPTL-NL-DCSE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RFIGLTNSFGFGGTNATLCIAGL-------------- 10 --------------------ML----SKCLQHFLKA-T---ISHPY-PAS---Y-SWL-IS-K--H-------------------------------------------RFYGTV-P-A-AML--RRRVVITGIGLVTPLGVGTQLVWDRL-LRGESGIVSVV--G-DE-----------Y-KNIPCSVAAYVPRGP----H--E-GQ-F----NEE----NFVSKSDAKSMSSSTIMAVGAAELALKDSGWH-P-KREA-D-Q--V----------ATGVAIGMGMVPLEVISETAL--------------------------LFQ-T-KGYNKVSPFFVPKILINMAAGQVSIRYKLKGPNHSVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALSS--NPDPKLACRPFHPERDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEILGYGLSGDAGHITAPDPEGEG-ALRCMAAAVKDA--------GV--SP-EQISYVNAHATSTPLGDAAENRAIKRLFRD-----------------------H--------------------------------A--CA--LAISST-----------------KGATGHLLGAAGAVEATFTALACYHQKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---E-S----QEWK-------AE--G-RCIGLTNSFGFGGTNATLCIAGM-------------- 11 ---------------ML---------SDGLQIFLRI-T---KCHLIHARS---C-QRL-VN-E--R-------------------------------------------RFLATA-P-A-PGL--RRRVVITGIGLVTPLGVGTQLVWDRL-VRGESGIVSLV--G-DE-----------Y-QSIPCSVAAYVPRGC----D--E-GQ-F----NEQ----NFVPKSDTKSMSPPTVMAIAAAELALKDAGWH-P-QSEA-D-Q--A----------ATGVAIGMGMVPLEVISETAL--------------------------TFQ-T-KGYSKVSPFFVPKILVNMASGQVSIRHKLKGPNHAVSTACTTGAHAVGDSFRFVAHGDADVMVAGGTDSCISPLSLAGFARARALST--NTDPKSACRPFHPQRDGFVMGEGAAVLVLE-----E------HRHALRRGA-R-VYAEIVGYGLSGDAGHITAPDPGGEG-AFRCMAAAVKDA--------GI--QP-EEVSYINAHATSTPLGDAAENKAIKQLFKD-----------------------H--------------------------------A--HV--LAVSST-----------------KGATGHLLGTAGAAEAAFTALACYHRKLPPTL-NL-DCTE-P-HF--D-L----------N--YVP---------L---K-A----QEWK-------AE--N-RRIALTNSFGFGGTNATLCIAGM-------------- 12 ------------------------------------------------------------------------------------------------------------------------MHP--KRRVVITGLGVCSSIGIGIERFWNSL-LKPVSGISATP--D--EF------------SFLPCRVAGIIGSEE----C--MSAK-EQTQHRVAASNT----SIDWRSLSRAAAFGIVAACEALTQAGWK-Q-DGLKH------------SPNTRSGIHFGVGMEGIQEIVDTSE--------------------------AINS--KKYKGIGPHALTRSLANMPAGAISRLWQLRGPCMAGNTACATGLHSIGDAYRMIQYGEADLMVAGGCEATVNPWAIAAFSRIRALTTRFNETPVEASRPFDALRDGFAMSEGAACMVLQ-----VWPPTADMASHFQPNS--PPIAEIIGFGRSADAHNLVAPDPIGDG-ALRSMQAALQDA--------Q--LDSLDQIDHINCHATSTPLGDTIELAAICRLLAS-HNAS------------------------------------------------HDRP--NP--IIVNSI-----------------KGHTGHLLGAAGAIESVYTALAVNRNIAVSNC-NL-HSPI-S-AS--ELERVLSANSESANSKEALDAFEKRVRLP---K-HKEPSVPLRNS----SIT--C-RRVALTNSFGFGGTNGTLVIAEWK------------E 13 ---------------ML---------SNCLPNFLKV-T---HPPLQYSRS---W-QRI-ISKK--R--------------------------------------------CFGTV-P-T-SRF--RRRVVITGIGLVSPLGVGTHLVWDRL-IRGESGIVSLV--G-EE-----------Y-KSIPCSVAAYVPRGS----D--E-GQ-F----NEQ----NFVSKSDIKSMSSPTIMAIGAAELALKDSNWH-P-QSET-D-Q--V----------ATGVAIGMGMVPLEVVSETAS--------------------------IFQ-A-KGYNKVSPFFVPKILINMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFCRARALST--NSDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEVLGYGLSGDAGHITAPDPEGEG-ALRCMTAAVKDA--------NV--QP-EEITYVNAHATSTPLGDAAENKAIKHLFKD-----------------------H--------------------------------A--HA--LAISST-----------------KGATGHLLGAAGATEAAFTALACYYRKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RCIGLTNSFGFGGTNATLCIAGM-------------- 14 ------M----------------------------------------------------------------------------------------------------------K-LPTS-LRQ--AVRVVVTGVGAVTPLGVGAGRSWERL-LACHSGIGKLT--G-EE-----------F-EKMPAKVAALVPRGK----E--E-H--Q----FDE----KQFTDAEWRQMSKATAFAVVAAEEALADAQWK-P-NTAN-E-L--H----------STGVSIGTGMIDLSDVIKTG--------------------------SRLA-E-QGPKIVSPYFIPRILPNMIAGYLAIRYGIKGPNHCVSTACSTGLHSIGDAFMMIQRGLADVMICGSAEASINALCVAGFCRIRALCTKFNSDPQEASRPFDSERDGFVMGEGAGVLILE-----E------LQHALERNA-R-IYAEVLGYGLSGDGYHLTSPCPDGAG-AKLSMRRALMDA--------GV--KP-EEVGYVNAHATSTKQGDSAETTAIYEIANE----GGK----------------R------------------------------SEQ--EQ--PLVSSC-----------------KGAIGHLLGAAGSVETIVTALSCYHGVVPPNR-NL-KKVD-V-PM--N-M-------N-----FSH-----S---E---K-A----TPFPTS--SFT----S-RRVAMKNSFGFWGANATLCLASMD------------Q 15 -----------------------------------------------------------------------------------------------------------------------------MYRVVITGMGAITPYGSGVQLLQKM-LLEGRSALQFS--DQ-LGF------------------VVGTIPES-------------S----VDF----NQWSSGDKREMSKASLLTLVAAEEVMSMSNAK-SVEHS------------------DTLVNIGTGVADLLEIGKTST--------------------------LVQ-N-GQSRKVSPYFVPRILTNLPAGYVAMKYHMMGGAESASTACATGLHCIGNAFRAVRYGWARRAIAGATESCVNPIALAGFERMRALSRG---KDPTCSRPFDKERNGFVLSEGVGLILLE-----R------LEDATKRAAP--ILAEVLGYGISSDCYHISRPDPTGIG-AKLSMQRAIYDA--------NI--ST-NDISYVNAHATSTPTGDAVEALAIRELFGK----R---------------------------------------------------R------IAVSSIK-----------------GHIGHLLAAAGAVETIATVEAIRDAKLPAN-LNL-NESD--DET--D-VA------------LLR---------Q-----V----TEWP-----------R-PRIAVVNSFGFGGTNASLVISEYQ--S---------- 16 ---------------MI---------LQHLRTVLRA-T---NLCLPSSQV---Q-QYL-NI-N--K-------------------------------------------RCT----R-L-VHG--RRRVVVTGIGLVSPLGVGTQLVWNNL-LQGNCGIVALE--G-EE-----------Y-ASVPCKVAACVPKGV----D--K-GH-F----HGE----NFITKSDSKAMSSATIMAIGAADLALKDSGWS-P-QSVQ-D-S--L----------KAGVAIGMGMVPLEDISDTAL--------------------------TFK-T-KGYNKVSPFFVPKILINMAAGHISIKHQLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMLAGGTEACISPLSLAGFARARALSTSFNSNPQKACRPFHPLREGFVMGEGAAVLVLE-----E------YMHAIQREA-K-PYAEILGYGLSADACHITAPDPNGDG-ASRCMSAAIKDS--------GI--SP-EDITYINAHATSTPLGDAAENQAIKTLFKG-----------------------H--------------------------------A--SA--LAVSST-----------------KGATGHLLGAAGAIEAAFTALACYHGILPPTL-NL-DQTE-P-LF--D-L----------N--YVP---------L---V-A----QEWK-------SK--K-RCIALSNSFGFGGTNASLCFANI-------------- 17 -----------------------------------------------------------------------------------------------------------------------------MYRVVITGMGAVTPYGGGVATLHKG-LLESRSALKFS--EQ-LGF------------------VVGAIPDG-------------S----VDF----DRWSAGQKREMSRASQLALIAAEEAISTSNAQ-DLDHK------------------DTLVNIGTGVADLLEIGRTTA--------------------------LVQ-N-GQTR----------------------YGMMGGAESAATACATGLHCIGNAFRSVRQGWARRAIAGAAEGCVNAVALAGFDRMRALSHG---KDPSCCRPFDKKRDGFVLSEGVGLVLLE-----R------LQDALDRGAP--ILAEVLGYGVSSDCYHISSPDPSGIG-ARLSMQRAIDDA--------KI--GP-DDVTYVNAHATSTPTGDIIEATAIREVYGE----R---------------------------------------------------N------IPVSSIKGLSLLST----------GHIGHLLAAAGSVEAIATVAAIVDAKLPEN-LNL-TECD--GGE--G-ID------------CLQ---------E-----V----KDWL-----------K-PRTAVVNSFGFGGTNASLVLTEFQ-EK---------- 18 ---------------MF---------SQCSQDLLKI-A---NLHLRGLNF---N-LHL-RN-H--R-------------------------------------------RAFS-K-S-L-PAC--RRKVVVTGIGLVSPLGVGTQLVWKRL-LQGDSGITSLD--G-EE-----------Y-AGIPCRVAACVPRGD----E--E-GQ-F----KEE----SFVSKSEVKSMSSATVMAIGAAELAIKDAGWS-P-QSEQ-D-R--L----------TAGVAIGMGMVPLEEISDTAS--------------------------LFK-T-KGYNKVSPFFVPKILVNMAAGQISIKYQLKGPNHAVSTACTTGAHAVGDSSRFIASGDADVMLAGGTEACISPLSLAGFARARALSTSFNSSPKMACRPFDSQREGFVMGEGAAVLVLE-----E------YEHAVQRGA-R-IYAEVLGYGLSGDACHITAPNPEGDG-AFRCMSAAIKDS--------GI--KP-EDVTYVNAHATSTPLGDAAENQAIKRLFKD-----------------------H--------------------------------S--RN--IAVSST-----------------KGATGHLLGAAGAIEAAFTALSCYHGILPPTL-NL-KQTE-P-GF--D-L----------N--YVP---------L---T-A----QEWK-------TA--K-RRIALTNSFGFGGTNATLCFASV-------------- 19 ---------------MF---------SNCLQNILKM-T---SPH-LYSRL---C-QQL-IS----K-------------------------------------------RLFGTVSS-T-SRW--HRRVVITGIGLVTPLGVGTQLVWDRL-IRGESGIVSVV--G-DE-----------Y-KSIPCSVAAYVPRGC----E--E-GQ-F----NEL----NFVSKSDLKSMSSPTIMAIGAAELAMKDSGWY-P-QSKA-D-Q--E----------ATGVAIGMGMTPLEIVSETAL--------------------------MFQ-T-KGYNKVSPFFVPKILINMAAGQVSIRYKLRGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALST--NSDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------HDHAVQRGA-R-IYAEVLGYGLSGDAGHITAPDPEGEG-ALRSMAAAVKDA--------NV--QP-EEISYVNAHATSTPLGDAAENKAIKYLFKD-----------------------H--------------------------------A--RA--LAISST-----------------KGATGHLLGAAGAVEAAFTALACYDRKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RCIGLTNSFGFGGTNATLCIAGM-------------- 20 --------------------------------------------------------------------------------------------------------------------------M--QRRVVVTGLGVVSPVGTGVKEAWKNI-ISGKSGITRLE--G-PE-----------Y-ESLPCKIGGYAKDKG----E-----K-I----SLS----NYFSKSELRTMAPATGFALISAKEALEDAKLD-Q-MDEN-T-K--N----------TAGVAVGMGMVDLQDICSTY---------------------DA-----LK-K-G-YHHVSPYFVPRILPNMAAGQISIKYGLRGPNHSVSTACATGAHAIGDSFRFIRNGDADIMICGGTESCISPLSIAGFSRLRALSTSFNDQPEKASRPFDKLREGFVMGEGSAVLILE-----E------LQHALDRNA-H-IYAELLGYGLSGDASHLTAPRSDGAG-ARSAMERALKDS--------RI--DS-KQVTYINAHATSTPIGDSIETRAIKDLFG-----P------------------S--------------------------------T--NN--ISVSST-----------------KGAHGHLLGAAGNLEALFTIKAIEEGVLPPTV-NL-ENIE---D-N-E-I-------N-----FVP---------I---I-S----QKWK-K----C----DR-RIALKNAFGFGGTNASLCFGQFI------------R 21 -----------------------------------M-F---NSTINGKFI---P-IFL-SQKI--R-------------------------------------------LIHRAA-LHQ-DNR--HRRVVVTGLGLLSPLGIGHVDSWQNL-IESKSGISSLE--K-NEQ----------F-SKLPCRIAGLIPDI-----------E-K----CLE----ENFTKNQLRTYSRAGLYGLLAVREAIQNAKWTRP-QNDL-E-A--S----------RCGVTIGSGMINFEDVIEAQR--------------------------QFD---RSYSRISPHFITKVLLNMPAGYVSMEYNLRGPNHTVSTACTTGAHAIGDAFNFIRNDYADLMIAGSVEAPINPLSIASFCQIRALCANSNQSPESASRPFDRDRSGFVMSEGAAICVLE-----E------LNHAIQRGA-P-ICGEILGYGLSADAHHITAPSEDGRG-ASESILSALRDA--------NL--TP-EKIGHINCHATSTPLGDQIELDAIKKIFKT-----------------------SS-----------------------------------S--LSITGT-----------------KGSHGHLLGAAGSAEFLFTLLTCLHGIIPPTL-NL-ENPI-D--T--E-I-------N-----IVA---------K---R-S----QRWTE----------S-RRIALSNSFGFGGTNATLVVSNYV------------K 22 ---------------ML---------SDCLQNFLKI-T---SPH-LGSRL---C-QPL-RGGK--R-------------------------------------------RLFGTV-P-T-SRF--RRRVVITGIGLVTPLGVGTQLVWDRL-IRGESGIMSLV--G-EE-----------Y-KSIPCSVAAYVPRGC----D--E-GQ-F----NEQ----NFVSKSDIKSMSSPTIMAIGAAELAMRDSGWL-P-QSEA-D-Q--A----------ATGVAIGMGMVPLEIVSETAL--------------------------MFQ-T-KGYSKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAQGDADVMVAGGTDSCISPLSLAGFSRARALST--NPDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------YDHAVQRGA-R-IYAEVLGYGLSGDAGHITAPDPEGEG-ALRCMAAAVKDA--------GV--QP-EEISYVNAHATSTPLGDAAENKAIKHLFKD-----------------------H--------------------------------A--PA--LAVSST-----------------KGATGHLLGAAGAVEAAFTALACYYQKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------IE--K-RCIGLTNSFGFGGTNATLCIAGM-------------- 23 -------------------------------------M---RPLCLYP---NLI-P------KVR---------------------------------------------N-----AST-QAS--RRRVVITGSGAVTPLANNVQESWNRI-LAGESAISRLG----PE-----------F-KGLPCQVAAQICRE-----------S-L----QLD----KKLTKTDIKLMSPATQLAVLAADEALAAGQLS-P-SKLT-A-EQRE----------RFGVCVGMGMFDLSEVYGTW---------------------QQ-----LQ-R-G-YNRVSPYFVPRLLPNMACGHISMRHGLQGPNHCVSTACATGAHAIGDALRFIRNGDADVMLAGSGEACIDPLSIAGFCRLRALSTAFNDNPAVASRPFDKSRDGFVMGEGAAVLLLE-----E------LEHARSRGA-P-ILAELLGYGLSGDAHHITSPSEDGAG-ATLAMKRAIKDA--------NI--SP-EEITYVNAHATSTPTGDRIESHAIGRVFG-----E------------------H--------------------------------T--PN--VRVSST-----------------KGAHGHLLGSSGNLEALFVVHACAENKLPPSI-NI-EQLD-V-D-V-N-V---------------V---------T---K-T----SNWL-Q----N----G-RRIALKNSFGFGGTNASLCIASYT------------- 24 -------------------------------------M---RVLGKCT---ILV-R------QTR---------------------------------------------S-----LST-QSG--RRRVVVTGSGAVTPLGNNGPDSWRRI-LAGESAISRLS----AE-----------F-KGLPCQVAAQIPRE-----------K-L----HLD----QHLTKSDIKLMSPATQFAVLAAEEALATGKLC-P-KQLS-E-EELE----------RFGVCVGMGMFDLAEVYGAW---------------------NQ-----LQ-R-G-YNRVSPFFVPRLLPSMACGHISMRHGLRGPNHSVSTACATGAHALGDAMRFIRSGDADVMLAGSGEACIDPLSIAGFCRLRALSTAFNDNPSVASRPFDKSRDGFVMGEGAAVLLLE-----E------LEHARARGA-P-ILAEILGYGLSGDAYHITSPSDDGAG-ATLAMKRAIQDA--------GI--AP-EDVTYVNAHATSTPTGDRIESHAIGRVFG-----A------------------H--------------------------------T--PQ--VRVSST-----------------KGAHGHLLGSSGNLEALFVVLACADNKLPPSI-NI-EHLD-V-D-V-N-V---------------V---------T---K-A----TEWS-A---DQ----K-RRVALKNSFGFGGTNASLCIASYI-E----------- 25 ----------------------------------------------MR----FL-S------QIR---------------------------------------------K-----AST-QAT--RRRVVVTGSGAVTPLANNVPESWRRL-LAGESAITKLG----AE-----------F-KGLPCQVAAQIPKD-----------R-L----QLD----KHLSKSDIKLMSPATQLAMMAADEALTSGKLK-P-SELS-A-EQRE----------RIGVCVGMGMFDLSEVYGAF---------------------QQ-----LQ-R-G-YNRVSPYFVPRLLPNMASGHISMRYGLQGPNHSVSTACATGAHAIGDALRFIRNGDADVMLAGSGEACIDPLSIAGFCRLRALSTAFNDSPAQASRPFDKARDGFVMGEGAALLLLE-----E------LEHAKARGA-P-ILAEILGYGLSGDAHHITSPSEDGTG-ATLAMQRAIKDA--------GV--TP-QDISYVNAHATSTPTGDRIEAHAIGRVFG-----E------------------H--------------------------------K--SQ--VLVSST-----------------KGAHGHLLGSSGNLEALFVVHACAENKLPPSI-NV-DQVD-V-D-I-N-V---------------V---------Q---K-T----CNWE-A---NQ----S-GRIALKNSFGFGGTNASLCIASYTG-----------N 26 ---------------ML---------SNCLLKFLKG-T---SSRPY-PAS---C-CWL-IS-K--R-------------------------------------------KFSGTT-P-A-AVS--LRRVVITGIGLVTPLGVGTQLVWGRL-LRGESGVVSVV--G-DE-----------Y-KSIPCSVAAYVPRGA----D--E-GQ-F----NEQ----NFVSKSDTKSMSSPTIMAIGAAELALKDSGWH-P-KLEA-D-R--V----------ATGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYNRVSPFFVPKILINMAAGQVSIRYKLKGPNHSVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALST--NPDPKLACRPFHPERDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEVLGYGLSGDAGHITAPDSEGEG-AFRCMAAAVKNA--------GV--LP-EQISYVNAHATSTPLGDAAENRAIKRLFGD-----------------------H--------------------------------A--GA--LAISST-----------------KAATGHLLGAAGAVEAAFTALACYHQKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---E-A----QEWK-------TE--G-RRIGLTNSFGFGGTNATLCLAGM-------------- 27 --------M------SV---------FSLFCWNKLR-LRPQ---NIRTLL---H-KNA-GVYQ--N-------------------------------------------QESRHH-SSG-RQQ--RRRVVITGIGLVCPLGTGIALSWDRL-IKGQSGVVSLD--S-EE-----------Y-RTLPCRVAALVPRGT----K--E-GQ-F----EEE----TFASRKEISSMSSATVMALGATQLALEDAGWC-P-KSPE-Q-Q--L----------TTGVAVGMGMVSLDEIARTAS--------------------------LFQ-E-KGYNKVSPFFVPRILVNMAAGHISIKHKLKGPNHAVSTACTTGAHAVGDAARFIAHGDAVAMVAGGTESCVGPLSLAGFARARALATKWNNNPTLASRPFHPEREGFVMGEGAAVLLLE-----D------LNHAVSRGA-R-IYAEVLGYGLSGDATHITAPTVDGDG-AFRCMSAALKDA--------DV--SL-ADVTYINAHATSTPLGDAAENAAIKRLFQQ-----------------------S--------------------------------A--SI--LAVSST-----------------KGATGHLLGAAGALEAAFTALACYHKVLPPTL-NL-DRTE-P-EF--D-L----------N--YVP---------C---T-A----QQWQ-------TR--G-RRVALTNSFGFGGTNASLCLGSI-------------- 28 ---------------ML---------SNCLQNFLKA-S---RSRPY-PAS---C-CCS-LS-K--R-------------------------------------------KFSGTM-P-A-VML--HRRVVVTGIGLVTPLGVGTQLVWDRL-LRGESGIVSVV--G-DE-----------Y-KSIPCRVAAYVPRGT----D--E-GQ-F----HEQ----NFVSKSDTKAMSSPTIMAIAAAELALTDSGWH-P-KSEA-D-Q--V----------ATGVAIGMGMVPLEVVSETAL--------------------------LFQ-T-KGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHTVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALSM--NPDPKLACRPFHPERDGFVMGEGAAVLVLE-----E------REHAVQRGA-R-IYAEVLGYGLSGDAGHITAPDSEGEG-AFRCMAAAVRDA--------GV--LP-EEISYVNAHATSTPLGDAAENRAIKRLFGD-----------------------H--------------------------------A--GA--LAISST-----------------KGATGHLLGAAGAIEAAFTALACYHQKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--G-RCIGLTNSFGFGGTNATLCIAGM-------------- 29 --------------------ML----SKCLQHFLKA-------HLY-PAS---Y-CWL-IS-K--H-------------------------------------------KFSGSV-P-A-AGS--RRRVVITGIGLVTPLGVGTQLVWDRL-LRGESGIVSVV--G-DE-----------Y-KSIPCSVAAFVPRGS----D--K-GQ-F----NEQ----NFVSKSDAKSMSSPTIMAVGAAELALKDSGWY-P-KLEA-D-Q--V----------ATGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYSKVSPFFVPKILINMAAGQVSIRYKLKGPNHSVSTACTTGAHAVGDSFRLIAHGDADVMVAGGTDSCISPLSLAGFSRARALST--NPDPKLACRPFHPERDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEVLGYGLSGDAGHITAPDPEGEG-ALRCMAAAVKDA--------GV--SP-DQISYVNAHATSTPLGDAAENRAIKRLFRD-----------------------H--------------------------------A--RA--LAISST-----------------KGATGHLLGAAGAVEAAFTALACYHHKLPPTL-NL-DCTE-A-EF--D-L----------N--YVP---------L---E-A----QEWK-------TE--G-RCIGLTNSFGFGGTNATLCIAGM-------------- 30 -----M--------------------------------------RKY---NTYL-N------LIR------------------------------------------------S-I-NTINAV--RRRVVVTGLGVVSPLGTGSELVWTNI-LKGKCGIVALN--D-EE-----------Y-INLPCRLAGLIPREK----------D-G----IVE----KALSKSTLKSMAPATSLALVATSEALKDANWT-P-KSEH-C-K--E----------MTGVAIGMGMIDLNDVCITN---------------------EA-----LK-V-G-YNKVSPFFVPRILPNMAAGHISIKYGFRGPNHSVSTACATGAHSIGDAFRFIKNGDADVMVCGGAEACISPLAIAGFCRLRALSTSFNGEPHKASRPFDKKRDGFVMGEGAAILILE-----E------YEHAFKRSA-K-MYAEILGYGLSGDASHITTPREDGSG-AMLSMARALKDG--------NL--QK-EDITYINAHATSTPIGDGIESTAIKSLFK-----E------------------H--------------------------------A--LK--ISVSST-----------------KGAHGHLLGAAGNLEAMFTILSCYHGVLPPTL-NL-DDPV-D-----D-L-------C-----YVA---------K---N-A----KKWDH----------E-KRIALKNSFGFGGTNASLCIANIL------------- 31 ---------------------------------MNN-G---LKKLEVIQR---A-SLI-CKNL--Y-------------------------------------------RRYYSN------RN--RRRVVVTGLGIVCPLGVGSKYVWKEL-VAGKSGISKIT--D-EG-----------Y-ESIPAKIAAFIPRG-----------S-----------------------------------------DVGH-L-DIKQ-W-F--N----------IVGVSIGCGIGGIKEIPVTGA--------------------------LLK-K-EGYRKVSPFFVPRILANMPAGVVSIHFGLQGPNHAVSTACAAGAHAIGDAFRMIIXGDADVMLAGGTESCITPLSMAGFCKARALTTKFNEKPLEASRPFDKDRSGFVIGEGAGIIVLE-----E------FNHAISRGA-D-IYAELHGYGMSGDAYHITAPREDGQG-AYLAMSAALRDA--------HL--HP-SDVSYINAHATSTPIGDAIESKAITRLLGE-----------------------G--------------------------------T--TG--TLISSS-----------------KGATGHLLGASGAVEAIFTVLAIKEKMVPPTL-NL-HSFD-N-SE--D-V-------H-AN--YVA---------N---T-A----QELIXK--Q--TS--T-RLIALTNSFGFGGTNASLCFGEI-------------E 32 ---------------ML---------SNGLQNFLKV-T---SPHLIHTGL---C-QRL-IS-E--R-------------------------------------------RFFGTV-P-T-PGL--RRRVVVTGIGLVTPLGVGTQLVWDRL-IQGESGIVSLV--G-EE-----------Y-KSVPCSVAAYVPRGC----D--E-GQ-F----NAQ----NFVPKSDIKSMSSPTVMAIGAAELALKDSGWH-P-QSEA-D-Q--V----------ATGVAIGMGMVPLEEISETAL--------------------------MFQ-T-KGYSKVSPFFVPKILISMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSLRFIAHGDADVMVTGGADSCISPLSLAAFSRARALST--NSDPKSACRPFHPKRDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEILGYGLSGDASHITAPDPGGEG-ALRCMAAALKDA--------GV--QP-EEISYINAHATSTPLGDAAENKAIKHLFKE-----------------------H--------------------------------A--HA--LAVSST-----------------KAATGHLLGAAGAAEAAFTSLACYHRKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RCIGLTNSFGFGGTNATLCIAGM-------------- 33 -------------------------------------M---RVLGKCT---ILV-R------QTR---------------------------------------------S-----LST-QSG--RRRVVVTGSGAVTPLGNNGPDSWRRI-LAGESAISRLS----AE-----------F-KGLPCQVAAQIPRE-----------K-L----HLD----QHLTKSDIKLMSPATQFAVLAAEEALATGKLC-P-KQLS-E-EELE----------RIGVCVGMGMFDLAEVYGAW---------------------NQ-----LQ-R-G-YNRVSPFFVPRLLPSMACGHISMRHGLRGPNHSVSTACATGAHALGDAMRFIRSGDADVMLAGSGEACIDPLSIAGFCRLRALSTAFNDNPSVASRPFDKSRDGFVMGEGAAVLLLE-----E------LEHARARGA-P-ILAEILGYGLSGDAYHITSPSDDGAG-ATLAMKRAIQDA--------GI--AP-EDVTYVNAHATSTPTGDRIESHAIGRVFG-----A------------------H--------------------------------T--PQ--VRVSST-----------------KGAHGHLLGSSGNLEALFVVLACADNKLPPSI-NI-EHLD-V-D-V-N-V---------------V---------T---K-A----TKWS-A---DQ----K-RRVALKNSFGFGGTNASLCIASYI-E----------- 34 ----------------M---------TCYTSGILRS-L---QLCNSFVKH---L-PRF-CSHK--R-------------------------------------------CCAT-Q-----HSS--RRRVVITGIGIVSPLGVGTQLVWDRL-IQGASGIGALE--R-EE-----------Y-KNLPCRVAACVPRGH----S--E-GQ-F----NEQ----CFVSRSEVKAMSSATIMALGAAEQAISDSGWK-P-ITEE-D-Q--V----------STGVALGMGMVPLDDISAAAM--------------------------LLQ-S-KGYNKISPFFVPRILVNMAAGHISIKYKLKGPNHAVSTACTTGAHAVGDSYRFIAYGDADVMVAGGTEACIGPLSLAGFARARALSTSFNLTPDLACRPFHPEREGFVMGEGAAVLILE-----E------YTHALARNA-R-IYAEILGYGLSGDACHITAPSSDGDG-AFRCMKAAIKNS--------HI--QV-EDITYINAHATSTPLGDAAENQAIKRLFGD-----------------------H--------------------------------A--YS--LAVSAT-----------------KGASGHLLGAAGSLEAAFTVLTCFHGILPPTL-NL-DRTE-P-EF--D-L----------N--YVP---------L---K-S----QEWK-------CR--N-RRVALSNSFGFGGTNASLCFASI-------------- 35 ------M---------------------------------------F---ISFV-I------INR------------------------------------------------T-LTTA-ARC--KRRVVVTGLGVVSPLGIGTQNAWQAL-ITSKSGITKLI--N-PE-----------Y-DKLPCKVGALIPKGN----N--P-NE-L----NID----SYFTKSELRTMCPATAYALIATEEALNNANWK-P-KDET-D-K--R----------DTGVAVGIGMIDLIDVCATY---------------------EA-----LK-K-G-YNKVSPYFVPRILPNMAAGQISIKYGFRGPNHSVSTACATGAHAIGDAFXFIRGGETSVMICGGAEACISPLAIAAFCRLRALSTNKNDFPYEASRPFDKDRDGXVMGEGAAILVLE-----E------LNHALERKA-N-IYAEVLGYGLSGDAAHLTAPSEDGTG-AILAMDRAIKDA--------GI--KS-VEITFINAHATSTPLGDSIELKAIESFMG-----H------------------H--------------------------------S--KN--ITVSST-----------------KGAHGHLLGAAGNLEAVFTILAIKEGIIPPTL-NL-HTLD-T-K-T-S-L-------S-----FAP---------N---V-K----KNWNTI---------S-RRVALKNAFGFGGTNACLCFAQYN-E----------- 36 ----------------M---------TCYTSGILRS-L---QLCNSFVKH---L-PRF-CSHK--R-------------------------------------------CCAT-Q-----HSS--RRRVVITGIGIVSPLGVGTQLVWDRL-IQGASGIGALE--R-EE-----------Y-KNLPCRVAACVPRGH----S--E-GQ-F----NEQ----CFVSRSEVKAMSSATIMALGAAEQAISDSGWK-P-ITEE-D-Q--V----------STGVALGMGMVPLDDISAAAM--------------------------LLQ-S-KGYNKISPFFVPRILVNMAAGHISIKYKLKGPNHAVSTACTTGAHAVGDSYRFIAYGDADVMVAGGTEACIGPLSLAGFARARALSTSFNLTPDLACRPFHPEREGFVMGEGAAVLILE-----E------YTHALARNA-R-IYAEILGYGLSGDACHITAPSSDGDG-AFRCMKAAIKNS--------HI--QV-EDITYINAHATSTPLGDAAENQAIKRLFGD-----------------------H--------------------------------A--YS--LAVSAT-----------------KGASGHLLGAAGSLEAAFTVLACFHGILPPTL-NL-DRTE-P-EF--D-L----------N--YVP---------L---K-S----QEWK-------CR--N-RRVALSNSFGFGGTNASLCFASI-------------- 37 -------------------------------------------------------------------------------------------------------------------MNHI-RYY--SRRVVVTGLGALSPLGRDVPTSWSAL-LDGKSGVTSTP--S-DAG----------F-EKLPCRVAAFINKPGE--Q-----PI-F----EAT----QVVSTSEVRTLSSASLHVLQAAEEALQDSQWK-P-STQA-D-L--E----------RTGVAIGMAMTDLDYIVDTG---------------------LA-----FR-G-GGLRKISPFFVPRILTNMASGAISLRYKFQGPNHSVATACATGIHAVGDAFQFIKYGKAEVMLCGGTECSISALSLAGFCRLRALSSKFNETPHAASRPFDKDRDGFIMGEGAAVLVLE-----E------LEHAKARGA-R-IHGELLGYGLAADAHHITAASEDGSG-AYLCMRNACEDA--------GL--NP-EQVEHVNAHATSTPGGDAAEAAAINRLFL-----N------------------G-----------------------------------AP--PFVSAT-----------------KSSTGHLLGAAGALETIFAVKAVSEGQVPPTL-NA-DVID-E-K-C-K-G-------I-----NLH---------R---T-A----TPWQSK---------Q-RRIALKNSFGFGGTNATLIVGQY-------------- 38 -------------------------------------M---RVLGKCN---ILV-R------QTR---------------------------------------------N-----LST-QSG--RRRVVVTGSGAVTPLGNNGPDSWRRI-LAGESAISRLS----PE-----------F-KGLPCQVAAQISRE-----------S-L----QLD----QHLTKSDIKLMSPATQLAVLAAEEALATGKLC-P-KQLS-E-EQLE----------RFGVCVGMGMFDLAEVYGAW---------------------NQ-----LQ-R-G-YNRVSPFFVPRLLPSMACGHISMRHGLRGPNHSVSTACATGAHALGDAMRFIRSGDADVMLAGSGEACIDPLSIAGFCRLRALSTAFNDNPAVASRPFDKSRDGFVMGEGAAVLLLE-----E------LEHARARGA-P-ILAEILGYGLSGDAYHITSPSDDGAG-ATLAMKRAIQDA--------GI--AP-EDITYVNAHATSTPTGDRIESHAIGRVFG-----N------------------H--------------------------------T--SQ--VRVSST-----------------KGAHGHLLGSSGNLEALFVVLACAHNKLPPSI-NI-EHLD-V-D-V-N-V---------------V---------T---K-A----TEWS-S---DQ----K-RRVALKNSFGFGGTNASLCIASYI-E----------- 39 --------------------------------------------MIGPRC---R-TRL-LHTR--P-------------------------------------------VSDIWV-KRK-SSK--SRNVVVTGIGIVSPLGCGVDFVWSRL-LKGCCGITNIH--F-NN-------------CDIPCKVGAGVPEGS----G--P-GQ-F----SAK----V--SR----EVSKATAFAAAAAEEALNDACWS-P-VTDV-D-Q--Q----------RTGVALGMGMVDLDAVSSTVN--------------------------DLN-A-KGYRAVSPYFIPRILLNMGAGHISMKYKLKGPNHSVSTACTTGAHAIGDAARFIIHNDADVMVAGGAESCLNVLAFSGFSKARALSTKYNDNPKVASRPFHPDRDGFVMGEGAAVLVLE-----E------EQHAVQRGA-K-IYASLLGYGLSADASHITAPPEDGNG-AYRCMKSAVQDA--------GV--KL-DEVTYINAHATSTPLGDAAENRAIKRLFQN-----------------------S--------------------------------P--P----AVSST-----------------KGAVAHMLGAAGAIEAAFTVLSCYHSQLPPTL-NL-DRTD-P-EM--D-L----------N--YVP---------L---T-T----QKWCP------KT--D-RRIALTNSFGFGGTNASLCFSSV-------------- 40 --------M------SV---------FTLFCWNKLR-LRPQ---NIRNLL---H-KNA-GVCP--N-------------------------------------------QESRHH-SSG-RQQ--RRRVVITGIGLVCPLGTGTALSWDRL-IKGQSGVVPLD--S-EE-----------Y-RTLPCRVAALVPRGT----K--E-GQ-F----EEE----TFASRKEISSMSSATVMALGATQLALEDAGWC-P-KSPE-E-Q--L----------STGVAVGMGMVSLDEIARTSS--------------------------LFQ-E-KGYNKVSPFFVPRILVNMAAGHISIKHKLKGPNHAVSTACTTGAHAVGDAARFIAHGDAVAMVAGGTESCVGPLSLAGFARARALATKWNNNPTLASRPFHPEREGFVMGEGAAVLLLE-----D------LNHAVSRGA-R-IYAEVLGYGLSGDATHITAPTVDGDG-AFRCMSAALKDA--------DV--SL-ADVTYINAHATSTPLGDAAENAAIKRLFQQ-----------------------S--------------------------------A--SI--LAVSST-----------------KGATGHLLGAAGALEAAFTALACYHKVLPPTL-NL-DRTE-P-EF--D-L----------N--YVP---------C---T-A----QQWQ-------TR--G-RRVALTNSFGFGGTNASLCLGSI-------------- 41 ------MI---------------------------L-K---SCVSIF---KCHL-YRL-CRKQYF---------------------------------------------LSVR-FSSN-VSD--ETRVVVTGLGIVCPLGVGVNHVWKQI-LNSQSAVSSIG--D-P-A----------Y-SDIPCKIAAFIPQGEN------E-GE-L----NIH----NFFKPSDFKKYSFSTICSLVAAEEAIADAAWF-P-KNDE-E-L--E----------YTGVAVGTGMIDLIDVVTTG---------------------NS-----LK-D-KGYRGMSPFFVPRILSNISAGHIAIKNGFKGPNHAVSTACATGLHAIGDAYNFIRNKQANVMICGSAEAVISPISIAGFSRMRALSTNFNDQPKKASRPFDKDRDGFVMGEGAGILVLE-----S------LSHAQKRKA-K-IYAEVLGYGLSGDAHHITSPPENGSG-AYRCMKQALSQS--------SI--KP-IEVGYINAHATSTPLGDGIELKAIYDLFK-----E------------------H--------------------------------S--SS--LVVSST-----------------KGSTGHLLGAAGSVEAIFTIMSCFSKTIPPNV-NL-DNAD-I-N-L-P-V-------N-----LAG---------K---K-F----ESWPEK---IQ----G-KIIGLTNSFGFGGTNASILFSKSD-YC---------L 42 ----------------------------MSIWTTVR-AIVQ---P-GRAF---L-RNA-HICP--K-------------------------------------------GVRLSS-GSG-QSH--RRRVVVTGLGLVCPLGTGCNLPWECL-IQGRSGIVALE--S-ED-----------Y-RGLPCRVAALVPRGA----D--E-GQ-F----KGD----RFVSRGEISNMSAATVMALGAAQLALEDAAWF-P-ESLE-E-Q--L----------STGVAVGMGMVSLDDIASTSA--------------------------AFQ-E-RGYKKVSPFFVPRILVNMAAGHISIKHKLKGPNHAVSTACTTGAHAVGDAARFIAHGDAVAMVTGGTESCVGPLSIAGFARARALATKWNDRPTLASRPFHPEREGFVMGEGAAVLLLE-----E------LEHAVKRGA-R-IYAEILGYGLSGDASHITAPSADGDG-AFRCMSAALKDA--------GI--SP-ADVTYINAHATSTPLGDAAENTAIKRLFCE-----------------------T--------------------------------T--ET--LAVSST-----------------KGATGHLLGAAGALEAAFTALACYHGVLPPTL-NL-DRTE-P-EF--S-L----------N--YVA---------C---K-A----EPWR-------TL--G-RRVALTNSFGFGGTNASLCLSSM-------------- 43 ---------------MF---------SNCLQNIIKI-T---NAHLLHSGL---C-HRL-IRNK--R--------------------------------------------CFGTV-P-T-SRL--HRRVVVTGIGLVTPLGVGTQLVWDRL-IRGESGIISLV--G-EE-----------Y-KNIPCRVAAFVPRGC----D--E-GQ-F----NEQ----NFASTSDLKSMSSPTIMAIGAAELAMKDSGWH-P-QSEA-D-Q--V----------ATGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYNKVSPFFVPKILVNMAAGQVSIRYKLRGPNHTVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFARARALST--NPDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEILGYGLSGDAGHITAPDSEGDG-ALRCMVAAVKDA--------NV--QP-EEISYVNAHATSTPLGDAAENKAIKRLFKD-----------------------H--------------------------------A--HA--LAISAT-----------------KGATGHLLGAAGAVEAAFTALACYYRQLPPTL-NL-DYTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RRIGLTNSFGFGGTNATLCIAGM-------------- 44 ------------------------------------------------------------------------------------------------------------------------GAE--MHRVVITGMGAVTPYGAGVPLLRKALLLESRSALKYS--DE-FGF------------------MVGAIPDE-------------E----EVF----QRWTA-------------------------------------------------------------------------------------------------------------------------------------------------------GNAFRAIRHGWARRAIAGASEGCVNAVSLAGFDRMRALSHG---KVPSCSRPFDRERDGFVLSEGVGLVILE-----R------LQDALDRGAP--VLAEIKGYGISSDCYHISSPDPSGIG-ARLSMQRAIEDA--------KI--SF-DEVNYVNAHATSTPTGDAIEALAIREVFGK----R---------------------------------------------------N------IAVSSIK-----------------GHIGHLLAAAGAVEVIATVEAIREMKLPSN-LNL-NESD--EDN--G-LA------------LLR---------Q-----V----TEWP-----------R-PRMAVVNSFGFGGTNASIVISEY---S---------- 45 -----------------------------------------------------------------------------------------------------------------------------MHRVVITGMGAVTPYGAGVPLLRKALLLESRSALKFS--ED-FGF------------------MVGAIPDE-------------E----DVF----QRWTAGQKREMSRASQLALVAAEENNDDI-------------------------------------------------------------------------------------------------------------------------ALVSLSGNAFRAIRHGWARRAIAGASEGCVNAVSLAGFDRMRALSHG---KVPSCSRPFDRERDGFVLSEGVGLVILE-----R------LQDALDRGAP--VLAEIKGYGISSDCYHISSPDPSGIG-ARLSMQRAIEDA--------KI--SS-DEVNYVNAHATSTPTGDAIEALAIREVFGK----R---------------------------------------------------N------IAVSSIKGIGLINQAGIITKKFVPGHIGHLLAAAGAVEVIATVEAIRVLGTHYRQLPT-RLND--NNN--K-LM------------FFS---------Q-----L----TILE-----------R------------GEE-----IGDF---R---------- 46 --------------------------MSLRCFQK--------SHFLSLSS---I-SQS-NII-------------------------------------------------KVCS-ARK-HSS--PRRVVITGIGLVCPLGTGSALPWQRL-IGGESGLVALN--G-EE-----------Y-KSVPCKVAARVPRGE----K--P-GD-F----TQE----SFASKAEINSMSQATVMAIGAANLALNDCGWY-P-RSPE-E-Q--E----------STGVAVGMGMVPLEEIYNTAS--------------------------AFQ-T-RGYSKVSPFFVPRILVNMAAGHISIKHKLKGPNHAVSTACTTGAHAVGDAARFISHGDAEVMLAGGTEACIGPLSIAGFARARALSTSWNHEPRLSSRPFHPDREGFVMGEGAAVLVLE-----E------FSRAQRRGA-R-VYAEIMGYGLSGDASHITAPTADGDG-AFRCMSAALRNA--------GL--SP-SDVSYINAHATSTPLGDAAENAAIKRLFEP-----------------------S--------------------------------V--LS--LAVSST-----------------KGATGHLLGAAGALETAFTALACHHAILPPTL-NL-DRTE-P-EF--N-L----------N--YVP---------C---A-A----QEWR-------TS--G-RRIALTNSFGFGGTNASLCLASV-------------- 47 -------------------------------------------------------------------------------------------------------------------------MA--SVRVVVTGLGLVTPLGLGVELCWRRL-LQGCIGAVELV--D-EK-----------Y-RGCVSRVAALVPAGV----G--P-G--L----FDR----SQFSDGQWRRMTKATAYAMLAAGEALADAQWT-P-VSDE-Q-R--E----------KTGVCVGVGMSDMEDVHEAGGKSARSSDLCIYFFSRLPLIDCLLPGCFID-Q-QRDNRLSPYFIPRVLTNMTAGQLSVSYGLRGPNHCPSTACASGLHAIIDGMALIQRRQAELMLVGGAEAPVCKLSLVGFGRMGALSRSFNGRPAEASRPFDRRRDGFVIGEGAGMLLLE-----R------LEHALQRRA-PHIYAELLGYGLSGDGLHLAAPCPYGSG-AASCMRKALHDS--------AV--PR-DCISYVNAHATSTPLGDRAEFQAIQDVFRG----S--------------------------------------------------DN--LP--VIVSSN-----------------KGSIGHLLGAAGAVEAAFTVLSCFHGSVPPNV-NL-HQTD-L-EAP-E-I-------Q-----LAP-----S---D---R-A----QHWTTP--SLN----Q-RKIALKNSFGFGGTNACLCIAQFQ------------E 48 ------------------------------------------------------------------------------------------------------------------------MHP--KRRVVITGLGVCSSIGIGIERFWNSL-LKPVSGISATP---------------------------GIIGSEE----C--VSAK-EQTQHRLAVSNT----SIDWRSLSRAAAFGIVAACEALTQAGWK-Q-DGLKH------------SPNNRSGVHFGVGMEGIQEIVDTSE--------------------------AINS--KKYKGIGPHALTRSLANMPAGAISRLWRLRGPCMAGNTACATGLHSIGDAYRMIQYGEADLMVAGGCEATVNPWAIAAFSRIRALTTRFNEAPIEASRPFDALRDGFAMSEGAACMVLQ-----AWPPTADTASHFQPNS--PPVAEIIGFGRSADAHNLVAPDPIGDG-ALRSMQAALHDA--------Q--LDSLDQIDHINCHATSTPLGDTIELAAICRLLAS-HNAS------------------------------------------------HDRP--NP--IIVNSI-----------------KGHTGHLLGAAGAIESVYTALAVNRNLAVSNC-NL-HSPI-S-AS--ELERVLSANSDSADTKKALDAFEKRLRLP---K-HKEPSVPLSNS----GST--C-RRVALTNSFGFGGTNGTLVIAEWK------------E 49 --------MIIRVSAML---------SDCLQNFLKI-T---STHLLYPRL---C-QRL-TRSK--R-------------------------------------------KFFGTV-P-T-SKL--HRRVVITGIGLVTPLGIGTQLVWDRL-IQGESGIVSMV--G-EE-----------Y-KSIPCSVAAFVPRGC----D--E-GQ-F----SEQ----NFVSKSDIKSMSSPTIMALGAAELAMKDSGWH-P-HSEA-D-Q--A----------ATGVAIGMGMIPLEVVSETAL--------------------------MFQ-A-KGYNKVSPFFVPKILINMAAGQISIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALST--NSDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEILGYGLSGDAGHITAPNPEGEG-ALRCMAAAVKDA--------GV--QP-EEISYINAHATSTPLGDAAENKAIKRLFKD-----------------------H--------------------------------A--YA--LAVSST-----------------KGATGHLLGAAGAVEAAFTTLACYHRKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RCIGLTNSFGFGGTNATLCIAGM-------------- 50 MNFERNVFMIIRVSAML---------SDCLQNFLKI-T---STHLLYPRL---C-QRL-TRSK--R-------------------------------------------KFFGTV-P-T-SKL--HRRVVITGIGLVTPLGIGTQLVWDRL-IQGESGIVSMV--G-EE-----------Y-KSIPCSVAAFVPRGC----D--E-GQ-F----SEQ----NFVSKSDIKSMSSPTIMALGAAELAMKDSGWH-P-HSEA-D-Q--A----------ATGVAIGMGMIPLEVVSETAL--------------------------MFQ-A-KGYNKVSPFFVPKILINMAAGQISIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALST--NSDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEILGYGLSGDAGHITAPNPEGEG-ALRCMAAAVKDA--------GV--QP-EEISYINAHATSTPLGDAAENKAIKRLFKD-----------------------H--------------------------------A--YA--LAVSST-----------------KGATGHLLGAAGAVEAAFTTLACYHRKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RCIGLTNSFGFGGTNATLCIAGM-------------- 51 ---------------ML---------SNCLQNFLKI-T---STH-LYSRL---C-QQL-IRN---K-------------------------------------------RFFGTG-P-I-SRL--HRRVVITGIGLVTPLGVGTQLVWDGL-LRGESGIVSLL--G-EE-----------Y-KSIPCSVAAFVPRGL----A--E-GQ-F----SEE----NFVSKSDIKTMSSPTIMAIGAAELALKDSGWH-P-QSEA-D-Q--V----------ATGVAIGMGMVPLEVVSEIAL--------------------------MFQ-T-KGYNKVSPFFVPKILINMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFKFIAHGDADVMVAGGTDSCISPLSLAGFCRARALST--NSDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------YEHAVQRRA-R-IYAEVLGYGLSGDAGHITAPDPEGEG-ALRCMSAAVRDA--------GV--QP-EEISYVNAHATSTPLGDAAENKAIKSLFKD-----------------------H--------------------------------A--YA--LAVSST-----------------KGATGHLLGAAGAVEAAFTALACYHRKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RCIGLTNSFGFGGTNATLCIAGM-------------- 52 --------------------------------------------------------------M-F---------------------------------------------VRRC-LNTS-PKG--ARRVVVTGLGLVTPLGVGTKPVWENL-LQSRSGIIRLG----K-E----------Y-DGIPSKIAGRVPTDVS--QN--P-AA-F----SID----RFASKSDLRSMTVATAYALAAAEEALADASWQ-P-KTDA-E-C--Q----------STGVAVGNAMTDLDYIVDSG---------------------LL-----FR-D-KGYAKMSPYFVPKILTNMAAGHISIRYNLRGPNHSVATACTTGLHAVGDAFNFIQRGYADVMVSGGTECSVSPICLAAFSRMRALST--AEDAATASRPFDRRRDGFVVAEGAAILVLE-----E------LRHALERDA-T-VYAEILGYGLSGDAVHITASSCEGEG-GLSCMRAALADA--------GI--DA-REVSYVNAHATSTPLGDAAEALAIRRLFG-----D------------------R--------------------------------S--QE--VAVSST-----------------KGATGHLLGAAGAVETAFTVLACHGGVIPPSL-NL-EAPD-E-K-M-D-L-------N-----FVA---------L---K-S----RVWETP---GS----K-RRVALKNSFGFGGTNGSLVIAEYK-N----------D 53 ------------I--ST---ML----SKCLQHFLKA-T---ISHPY-PAS---Y-SWL-IS-K--H-------------------------------------------RFYGTV-P-A-AML--RRRVVITGIGLVTPLGVGTQLVWDRL-LRGESGIVSVV--G-DE-----------Y-KNIPCSVAAYVPRGP----H--E-GQ-F----NEE----NFVSKSDAKSMSSSTIMAVGAAELALKDSGWH-P-KREA-D-Q--V----------ATGVAIGMGMVPLEVISETAL--------------------------LFQ-T-KGYNKVSPFFVPKILINMAAGQVSIRYKLKGPNHSVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALSS--NPDPKLACRPFHPERDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEILGYGLSGDAGHITAPDPEGEG-ALRCMAAAVKDA--------GV--SP-EQISYVNAHATSTPLGDAAENRAIKRLFRD-----------------------H--------------------------------A--CA--LAISST-----------------KGATGHLLGAAGAVEATFTALACYHQKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---E-S----QEWK-------AE--G-RCIGLTNSFGFGGTNATLCIAGM-------------- 54 ---------------MH---------LRCAKDLLKT-A---YFSLHSSQT---H-RSL-RA-I--K-------------------------------------------RCLSSG-T-I-LRD--RRRVVVTGIGLVSPLGVGAQLVWNNL-LQGNCGIIALE--E-EE-----------Y-STVPCKVAACVPKGT----G--E-GE-F----HGE----SYVSKSESKAMSSATVMAIGAADLALKDSGWH-P-QSDL-D-C--L----------HAGVAIGMGMVPLEEISNTAL--------------------------MFK-T-KGYNKVSPFFVPKILVNMAAGHISIKHQLKGPNHAVSTACTTGAHAVGDAFRFVAYGDADVMLAGGTEACISPLSLAGFARARALSTSFNSSPKLACRPFHSLREGFVMGEGAAVLVLE-----E------YQHAVQRGA-K-IYAEILGYGLSGDACHITAPNPDGDG-AFRCMSAAIKDA--------GI--RP-EDVTYINAHATSTPLGDAAENQAIKRLFKE-----------------------H--------------------------------A--YS--LAVSST-----------------KGATGHLLGAAGAIEAAFTVLACHHGILPPTL-NL-DQTE-P-PF--D-L----------N--YVP---------L---V-P----QEWS-------NE--K-CRIGLSNSFGFGGTNATLCFANV-------------- 55 ---------------ML---------SNCSQNIVKI-T---TAHILYSGF---C-HRV-V-NK--R-------------------------------------------RFFGTG-P-A-PGR--RRRVVVTGIGFVTPLGVGTQLVWDRL-IRGESGIVSLA--G-EG-----------Y-RGLPCSVAAFVPRGG----D--E-GQ-F----NEQ----NFVSKSDLKAMSSPTIMAIGAAELALEDSGWH-P-QSEA-D-Q--V----------ATGVAIGMGMVPLEVISETAL--------------------------MFQ-T-KGYNKVSPFFVPKVLVNMAAGQVSIRYKLRGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFARARALST--NPDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------HEHAIQRGA-R-IYAEVLGYGLSGDAGHITAPDSEGEG-ALRCMVAAVKNA--------NV--PP-EEISYVNAHATSTPLGDAAENKAIKHLFKD-----------------------H--------------------------------A--HA--LAVSST-----------------KAATGHLLGAAGAVEAAFTALACYHRQLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RRIGLTNSFGFGGTNATLCIAGM-------------- 56 -----------------------------MRVLRER-A---GAGLSERAY---A-SAH-CRHR--R-------------------------------------------RLHESP-E-D----------LVEGIGLVTPLGVGTQLVWDRL-IRGESGIISLV--G-EE-----------Y-KSIPCHVAAFVPRGC----D--E-GQ-F----NEQ----NFVSKSDLKSMSSPTIMAIGAAELAMKDSSWH-P-QSEA-D-Q--V----------ATGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYNKVSPFFVPKILINMAAGQVSIRYKLRGPNHAVSTACTTGAHAVGDSFRLIAHGDADVMVAGGTDSCISPLSLAGFARARALST--NPDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEILGYGLSGDAGHITAPDSEGDG-ALRCMVAAVKDA--------NV--QP-EEISYVNAHATSTPLGDAAENKAIKRLFKG-----------------------H--------------------------------A--HA--LAISAT-----------------KGATGHLLGAAGAVEAAFTALACYYRQLPPTL-NL-DYTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RRIGLTNSFGFGGTNATLCIAGM-------------- 57 ---------------MF---------SNCLQNIIKI-T---NAHLLHSGL---C-HQL-IRNK--R-------------------------------------------RCFGTV-P-T-SRL--HRRVVVTGIGLVTPLGVGTQLVWDRL-IRGESGIISLV--G-EE-----------Y-KSIPCHVAAFVPRGC----D--E-GQ-F----NEQ----NFVSKSDLKSMSSPTIMAIGAAELAMKDSSWH-P-QSEA-D-Q--V----------ATGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYNKVSPFFVPKILINMAAGQVSIRYKLRGPNHAVSTACTTGAHAVGDSFRLIAHGDADVMVAGGTDSCISPLSLAGFARARALST--NPDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEILGYGLSGDAGHITAPDSEGDG-ALRCMVAAVKDA--------NV--QP-EEISYVNAHATSTPLGDAAENKAIKRLFKG-----------------------H--------------------------------A--HA--LAISAT-----------------KGATGHLLGAAGAVEAAFTALACYYRQLPPTL-NL-DYTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RRIGLTNSFGFGGTNATLCIAGM-------------- 58 ------MF--------------------------S-----------R---INFL-K------KGR------------------------------------------------S-LTTN-VRS--KRRVVVTGLGLVCPLGVGVQYAWNNL-LESKCGITKLS--D-LD-----------Y-EKLPCKVAALIPKGN----Q--S-HE-L----NIE----SYFSKSELRTMCPATAYALISSEEALSDAKWK-P-EEEN-D-K--R----------DTGVAVGIGMIDLVDVYSTY---------------------EA-----LK-K-G-YNKVSPYFVPRILPNMAAGHISIKYGFRGPNHCVSTACATGAHAIGDAFRFIRGGETNVMVCGGAEACISPLAVAAFCRLRALSTSRNDFPYEASRPFDRDRDGFVMGEGSAILVLE-----E------LNHALNRQA-P-IYAEILGYGLSGDAAHITAPSEDGTG-ALLAMDRAVKDA--------GI--EI-SEITYINAHATSTPLGDAIELKAVESLMG-----E------------------H--------------------------------S--KN--VFISST-----------------KGAHGHLLGAAGNLEAAFTILAIKDAVIPPTI-NL-HNLD-T-K-T-S-L-------Q-----LVP---------N---E-K----KNWTSS---------S-RRIALKNAFGFGGINACLCFAEYI-V----------- 59 -------------------------------------------------------------------------------------------------------------------------MC--GRRVVVTGAGLVSCLGSDVKKVWQRL-LAGDSGISCLK--D-KA-----------Y-QNIPCRIAGIVPRSAQNDDS--S-DI-V----NID----AFVTPSQKKILSLSSIYALIAAENALNDSQWE-P-KSEM-D-R--L----------RTGVAVGVGMVDMEEIVHSGK--------------------------TLH-E-KGYKKVSPFFIPKILINMAAGHISMKHSLHGPNHSVSTACATGLHSIGDAFRLIKYNSADVMLAGGVDAAVNPLAIAGFAKIRALSTNFNDEPHKSSRPFDRQRDGFVMSEGAALLVLE-----E------LEHAKQRNA-P-IYAEVLGYGLTGEANHITAPREDGYG-SFHCMKMAIEEA--------GV--DV-SAINYINAHATSTPLGDAAEIRAIRRLFGD-----------------------H--------------------------------C--DK--LMISST-----------------KGATGHLLGGAGSIEALFTVLSLKTGDIPPTI-NL-ENPD-E-EF--TGL----------D--LVP---------I---R-N----SKLID------DS--R-RWIALSNSLGFGGTTACVCFGSMP-LAK--------S 60 -------------------------------------------------------------------------------------------------------------------------MA--SVRVVVTGLGLVTPLGLGVELCWRRL-LQGCIGAVELV--D-EK-----------Y-RGCVSRVAALVPAGV----G--P-G--L----FDR----SQFSDGQWRRMTKATAYAMLAAGEALADAQWT-P-VSDE-Q-R--E----------KTGVCVGVGMSDMEDVHEAG--------------------------CLID-Q-QRDNRLSPYFIPRVLTNMTAGQLSVSYGLRGPNHCPSTACASGLHAIIDGMALIQRRQAELMLVGGAEAPVCKLSLVGFGRMGALSRSFNGRPAEASRPFDRRRDGFVIGEGAGMLLLE-----R------LEHALQRRA-PHIYAELLGYGLSGDGLHLAAPCPYGSG-AASCMRKALHDS--------AV--PR-DRISYVNAHATSTPLGDRAEFQAIQDVFRG----VIC-----------------------------------------------SDN--LP--VIVSSN-----------------KGSIGHLLGAAGAVEAAFTVLSCFHGSVPPNV-NL-HQTD-L-EAP-E-I-------Q-----LAP-----S---D---R-A----QHWTTP--SLN----Q-RKIALKNSFGFGGTNACLCIAQFQ------------E 61 ------L--------------------------------------------------------FY------------------------------------------------S-IVRQ-RMA--SVRVVVTGLGLVTPLGVGVELCWQRL-LQGGVGVVGLV--D-DK-----------Y-RGCVSRVGALVPAGV----G--P-G--L----FDR----TQFSDGQWRRMTKATAYAMLAAGEALADAQWT-P-VSDE-Q-R--E----------KTGVCVGVGMADMEDVHEAG--------------------------CLVD-Q-QRDNKLSPYFIPRVLTNMTAGQLSISYGLRGPNHCPSTACASGLHAIIDGMALIQRRQAELMLVGGAEAPVCKLSVVGFGRMGALSRHFNSRPGEASRPFDRQRDGFVIGEGAGMLLLE-----R------LEHALERRA-PNIYAELLGYGLSGDGLHLAAPCPNGSG-AASCMRKALHDS--------AL--PR-DCISYVNAHATSTPLGDRAEFQAIANVFRG----S--------------------------------------------------VN--LP--VIVSSN-----------------KGSIGHLLGAAGAVEAAFTVLSCFHGSVPPNV-NL-QQTD-L-QAP-E-I-------Q-----LAP-----S---D---R-A----QHWTTP--SAG----R-RKIALKNSFGFGGTNACLCIAQFQ------------Q 62 -------------------------------------------------------------------------------------------------------------------------MA--SVRVVVTGLGLVTPLGVGVELCWQRL-LQGGVGVVGLV--D-ER-----------Y-RGCVSRVAALVPAGV----G--P-G--L----FDP----KQFSDGQWRRMTKATAYAMLAAGEALADAQWT-P-VSEE-Q-R--E----------KTGVCVGVGMADMEDVHEAG--------------------------CLVD-R-QRDNKLSPYFIPRMLTNMTAGQLSISYGLRGPNHCPSTACASGLHAIIDGMALIQRRQAELMLVGGAEAPICKLSVVGFGRMGALSRHFNSRPGEASRPFDRQRDGFVIGEGAGMMLLE-----R------LEHALERRA-PNIYAELLGYGLSGDGLHLAAPCPN-----------ALHDS--------AL--SH-DS---------------------IANVFHG----S--------------------------------------------------VN--LP--VIVSSN-----------------KGSIGHLLGAAGAVEAAFTVLSCFHGSVPPNV-NL-QQTD-L-QAP-E-I-------Q-----LAP-----S---D---H-A----QNWTTP--SAG----Q-RKIALKNSFGFGGTNACLCIAQFQ------------E 63 -------------------------------------------------------------------------------------------------------------------------MA--SVRVVVTGLGLVTPLGVGVELCWRRL-LQGCIGAVELV--D-EK-----------Y-GGCVSRVAALVPAGV----G--P-G--L----FDR----SQFSDGQWRRMTKATAYAMLAAGEALADAQWT-P-VSDE-Q-R--E----------KTGVCVGVGMSDMEDVHEAG--------------------------CLID-Q-QRDNRLSPYFIPRVLTNMTAGQLSVSYGLRGPNHCPSTACASGLHAIIDGMALIQRRQAELMLVGGAEAPVCKLSLVGFGRMGALSRSFNDRPAEASRPFDSRRDGFVIGEGAGMLLLE-----R------LEHALQRRA-PHIYAELLGYGLSGDGLHLAAPCPHGSG-AASCMRKALHDS--------AV--PR-DRISYVNAHATSTPLGDRAEFQAIQDVFRG----AICLFVCLFSSLMPQDFCSA------------------------------SDN--LP--VIVSSN-----------------KGSIGHLLGAAGAVEAAFTVLSCFHGSVPPNV-NL-HQTD-L-EAP-E-I-------Q-----LAP-----S---D---R-A----QHWATP--SLN----Q-RKIALKNSFGFGGTNACLCIAQFQ------------E 64 ------MV--------------------------S-----------R---INFL-K------KGR------------------------------------------------S-LTTA-VRS--KRRVVVTGLGLICPLGVGVQHAWKNL-LESKCGITKLS--D-LD-----------Y-EKLPCKVAALIPKGD----Q--S-HE-L----NIE----SYFSKSELRTMCPATAYALISSEEALSDARWK-P-EEEN-D-K--R----------DTGVAVGIGMIDLVDVCSTY---------------------EA-----LK-K-G-YSKVSPYFVPRILPNMAAGHISIKYGFRGPNHCVSTACATGAHAIGDAFRFIRGGETNVMVCGGAEACISPLAVAAFCRLRALSTSRNDFPYEASRPFDRDRDGFVMGEGSAILVLE-----E------LNHALSRQA-P-IYAEILGYGLSGDAAHITAPSEDGTG-ALLAMDRAVKDA--------GI--EI-SEITYINAHATSTPLGDTIELKAVESLMG-----E------------------H--------------------------------S--KN--VYISST-----------------KGAHGHLLGAAGNLEAVFTIMAIKDAVIPPTI-NL-HNLD-T-K-T-S-L-------H-----LVP---------N---E-K----KNWSAT---------S-RRIALKNAFGFGGINACLCFAEYI-V----------- 65 -------------------------------------------------------------------------------------------------------------------------MA--SVRVVVTGLGLVTPLGVGVELCWRRL-LQGCIGAVELV--D-EK-----------Y-RGCVSRVAALVPAGV----G--P-G--L----FDR----SQFSDSQWRRMTKATAYAMLAAGEALADAQWT-P-VSDE-Q-R--E----------KTGVCVGVGMSDMEDVHEAG--------------------------CLID-Q-QRDNRLSPYFIPRVLTNMTAGQLSVSYGLRGPNHCPSTACASGLHAIIDGMALIQRRQAELMLVGGAEAPVCKLSLVGFGRMGALSRSFNGRPAEASRPFDRRRDGFVIGEGAGMLLLE-----R------LEHALQRRA-PHIYAELLGYGLSGDGLHLAAPCPYGSG-AASCMRKALHDS--------AV--PR-DRISYVNAHATSTPLGDRAEFQAIQDVFRG----S--------------------------------------------------DN--LP--VIVSSN-----------------KGSIGHLLGAAGAVEAAFTVLSCFHGSVPPNV-NL-HQTD-L-EAP-E-I-------Q-----LAP-----S---D---R-A----QHWTTP--SLN----Q-RKIALKNSFGFGGTNACLCIAQFQ-DHN--------R 66 ---------------MF---------SNCLQNIIKI-T---HAHLLHSGL---C-HRL-VRNK--R-------------------------------------------RCFGTV-P-T-SRL--HRRVVVTGIGLVTPLGVGTQLVWDRL-IRGESGIISLA--G-EE-----------Y-KNIPCRVAAFVPRGC----D--E-GQ-F----NEQ----NFASTSDLKSMSSPTIMAIGAAELAMKDSGWH-P-QSEA-D-Q--V----------ATGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYNKVSPFFVPKILVNMAAGQVSIRYKLRGPNHTVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFARARALST--NPDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEILGYGLSGDAGHITAPDSEGDG-ALRCMVAAVKDA--------NV--QP-EEISYVNAHATSTPLGDAAENKAIKRLFKD-----------------------H--------------------------------A--HA--LAISAT-----------------KGATGHLLGAAGAVEAAFTALACYYRQLPPTL-NL-DYTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RRIGLTNSFGFGGTNATLCIAGM-------------- 67 --------------------------------------------------MNLV-Q------QVR------------------------------------------------Y-L-TK-FQS--QRRVVVTGLGVVSPIGTGTKLVWDNL-LKGHCGIVCLQ--E-ED-----------Y-KKLPCRIAGLISKQ-----------D-D----DIQ----KALSKANLKSMAPATCLALVATAEALVDSKWF-P-ESDR-E-K--E----------ITGVALGMGMIDLKDVCDTN---------------------EA-----LK-I-G-YNKVSPFFVPRILPNMAAGQISIKYGFRGPNHSVSTACATGAHSIGDAYRFIKYGDADVMVCGGAESCISPLAIAGFCRLRALSTSFNDEPEKASRPFDQKRDGFVMGEGAAVLVLE-----E------YEHALRRNA-K-IYAEILGYGLSGDGSHITAPREDGSG-AILSMSRALQDA--------NI--TK-NEITYVNAHATSTPIGDGIESTAIKKLFG-----E------------------H--------------------------------S--SK--ISVSST-----------------KGAHGHLLGAAGNLEAVFTILACHHGVIPPTL-NL-ENPV-D-----D-L-------N-----YVA---------K---V-P----EKWHT----------E-RRVALKNSFGFGGTNATLCIAQI-------------- 68 --------------------------------------------------MKLV-Q------QVR------------------------------------------------Y-L-TK-YQS--QRRVVVSGLGVVSPIGTGTKIVWDNL-LKGHCGIVCLQ--E-ED-----------Y-KKLPCRIAGLISKQ-----------D-D----DVQ----KALSKANLKSMAPATCLALVATAEALVDAKWF-P-ECDR-E-K--E----------MTGVALGMGMIDLKDVCDTN---------------------EA-----LK-I-G-YNKVSPFFVPRILPNMAAGQISIKYGFRGPNHSVSTACATGAHSIGDAYRFIKYGDADVMVCGGAESCISPLAIAGFCRLRALSTSFNDEPEKASRPFDQKRDGFVMGEGAAVLVLE-----E------YEHALRRNA-K-IYAEILGYGLSGDGSHITAPREDGSG-AMLSMGRALQDA--------NI--RK-NEITYVNAHATSTPIGDGIESTAIKKLFG-----G------------------H--------------------------------S--SK--ISVSST-----------------KGAHGHLLGAAGNLEAVFTILACQHGVIPPTL-NL-ENPV-D-----D-L-------N-----YVA---------N---V-P----EKWQT----------E-RRVALKNSFGFGGTNATLCIAQI-------------- 69 --------M------SA---------ALLSRVMELR-LRSR---CLGSAL---Q-KVL-FCPT--H-------------------------------------------QPRQQL-CGR-QPK--RRRVVVTGIGLVSPLGTGTALTWDGL-IRGQSGIVALD--S-EE-----------Y-RTVPCRVAALVPRGT----N--E-GQ-F----CEE----KFATRGEINTMSPATVMALGAAQLALDDAGWY-P-QTPE-D-Q--L----------NTGVAVGMGMVSLEEIASTSA--------------------------AFR-D-RGYNRVSPFFVPRILVNMAAGHISIRHKLKGPNHAVSTACTTGAHAIGDAARFIAHGDAIAMVAGGTESCVGPLSIAGFARARALATKWNDSPRLASRPFHPERGGFVMGEGAAVLLLE-----E------LEHALRRRA-R-VYAEVLGYGLSGDASHITAPTADGDG-PLRCMSAALRDA--------GV--SP-ADVTYVNAHATSTPLGDAAENAAIKRLFGS-----------------------S--------------------------------S--DR--LAVSST-----------------KGATGHLLGAAGALEAAFTALACYHGTLPPTL-NL-DRTE-P-EF--S-L----------N--YVP---------C---T-A----QPWP-------SQ--G-PRVALTNSFGFGGTNASLCLSSF-------------E 70 --------M------SV---------FSLFCWNKLR-LRPQ---NIRTLL---H-KNA-GVCP--N-------------------------------------------QESRHH-SSG-RQQ--RRRVVITGIGLVCPLGTGTALSWDRL-IKGQSGVVSLD--S-EE-----------Y-RTLPCRVAALVPRGT----K--E-GQ-F----EEE----TFASRKEISSMSSATVMALGATQLALEDAGWC-P-KSPE-Q-Q--L----------STGVAVGMGMVSLDEIARTAS--------------------------LFQ-E-KGYNKVSPFFVPRILVNMAAGHISIKHKLKGPNHAVSTACTTGAHAVGDAARFIAHGDAVAMVAGGTESCVGPLSLAGFARARALATKWNNNPTLASRPFHPEREGFVMGEGAAVLLLE-----D------LNHAVSRGA-R-IYAEVLGYGLSGDATHITAPTVDGDG-AFRCMSAALKDA--------DV--SL-ADVTYINAHATSTPLGDAAENAAIKRLFQQ-----------------------S--------------------------------A--SI--LAVSST-----------------KGATGHLLGAAGALEAAFTALACYHKVLPPTL-NL-DRTE-P-EF--D-L----------N--YVP---------C---T-A----QQWQ-------TR--G-RRVALTNSFGFGGTNASLCLGSI-------------- 71 ---------------------------------------------MT---SNIV-H------HLK------------------------------------------------F-F-SQ-YPS--RRRVVVTGLGVVSPLGTGTEVVWKSL-LKGRCGIVSLT--G-EE-----------Y-LKLPCRIAGVVPIEK----------V-G----KVA----KAMSKANLKSMAPATCLALVATEEALLDANWL-P-EAGL-D-K--E----------ATGVAIGMGMVDLKDVCDTN---------------------EA-----LK-L-G-YNKVSPFFVPRILPNMAAGQISIKYGFRGPNHAVSTACATGAHSIGDASRFIRNGDADVMVCGGAESCISALAIAGFCRLRALSTSFNDEPTKASRPFDKKRDGFVMGEGAAVLVLE-----E------YEHALRRNA-K-IYAEILGYGLSGDASHITAPREDGSG-AILSMSRALRDS--------GI--DK-EQVTHINAHATSTPIGDGIESTAIRSLFG-----E------------------H--------------------------------A--RK--MLISST-----------------KGAHGHLLGAAGNLESIFAVLSCYHGVIPPII-NL-EDPV-D-----D-L-------N-----YVA---------K---E-A----KKWES----------D-RRVALKNSFGFGGTNATLCIAQMN------------K 72 ---------------------------------------------MK---SNLA-I------QFR------------------------------------------------R-A-SN-VIP--RRRVVVTGVGVVSPLGVGADVVWKNL-LGGKSGIVSLQ--G-EE-----------Y-SKLPCKVAGVIPYQK----------D-D----TVA----KALSKSNLRTMAPATCLALVATAEALSNANWL-P-KNDD-E-R--E----------STGVAIGMGMIDLKDVCDTN---------------------EA-----FK-L-G-YNKVSPFFVPRILPNMAAGQISIKYGLRGPNHAVSTACATGAHSIGDAFRFICNGDADVMVCGGAEACISPLALAGFCRLRALSTSFNDEPTKASRPFDKLREGFVMGEGAAVLVLE-----E------YQHALRRSA-K-IYAEILGYGLSGDASHITTPREDGSG-ALLSMSRALKDS--------SI--DK-NNVTHINAHATSTPIGDGIESTAIKRLFG-----D------------------H--------------------------------T--PN--INVSST-----------------KGAHGHLLGAAGNLEAIFTVLSCYHGMLPPTL-NL-EDPV-D-----D-L-------N-----YVA---------K---E-S----RPWEA----------E-RRIALKNSFGFGGTNATLCISQL-------------- 73 -----M---------------------------SNI-I---YSRINT---MKLV-Q------QVR------------------------------------------------Y-L-TK-YQS--QRRVVVSGLGVVSPIGTGTKIVWDNL-LKGHCGIVCLQ--E-ED-----------Y-KKLPCRIAGLISKQ-----------D-D----DVQ----KALSKANLKSMAPATCLALVATAEALVDAKWF-P-ECDR-E-K--E----------MTGVALGMGMIDLKDVCDTN---------------------EA-----LK-I-G-YNKVSPFFVPRILPNMAAGQISIKYGFRGPNHSVSTACATGAHSIGDAYRFIKYGDADVMVCGGAESCISPLAIAGFCRLRALSTSFNDEPEKASRPFDQKRDGFVMGEGAAVLVLE-----E------YEHALRRNA-K-IYAEILGYGLSGDGSHITAPREDGSG-AMLSMGRALQDA--------NI--RK-NEITYVNAHATSTPIGDGIESTAIKKLFG-----G------------------H--------------------------------S--SK--ISVSST-----------------KGAHGHLLGAAGNLEAVFTILACQHGVIPPTL-NL-ENPV-D-----D-L-------N-----YVA---------N---V-P----EKWQT----------E-RRVALKNSFGFGGTNATLCIAQI-------------- 74 --------------------------------------------------MKLV-Q------QVR------------------------------------------------Y-L-SK-FQS--QRRVVISGLGVVSPIGTGTNLVWDNL-LKGHCGIVGLQ--D-EG-----------Y-KKLPCRIAGLISKQ-----------D-E----NIQ----KTLSKANLKSMAPATCLALVATAEALDDSQWF-P-ETDS-E-K--E----------FTGVALGMGMIDLKDVCDTN---------------------EA-----LK-I-G-YNKVSPFFVPRILPNMAAGQISIKYGFRGPNHSVSTACATGAHSIGDAYRFIKYGDADVMVCGGAESCISPLAIAGFCRLRALSTSFNDEPEKASRPFDQKRDGFVMGEGAAVLVLE-----E------YEHALKRNA-K-IYAEILGYGLSGDGSHITAPREDGSG-AMLSMGRALQDA--------NI--TK-NEITYVNAHATSTPIGDGIESTAIKKLFG-----E------------------H--------------------------------S--SK--ISISST-----------------KGAHGHLLGAAGNLEAVFTILACYHGVIPPTL-NL-ENPV-D-----E-L-------H-----YVA---------K---A-P----EKWIT----------E-RRVALKNSFGFGGTNATLCIAQI-------------- 75 ------------------------------------------------------------------------------------------------------------------------------------------------MQSWDNL-LSGMCGIDAI--TI-FST------------DGLPCKIAAEIKTDK----D-SD-IF-F----DES----LYVSPKDRRKIDRFILYGIAASDQAVKDSGWV-PESDY--DR---E----------MTSVIVGSGIGGLPLTEDSAI--------------------------RLK-E-YGFKKISPFTIPGILPNLLPGHIAIRNKYFGVNMSIVTACASGSHAIGNAFDMIRYGKANVVLAGGAEAALTPLSVAGFGAGRALSTGFNDNPKNASRPWDRDRDGFVIGEGAGMIVLE-----N------YEHAKRRGA-K-IYAELSGYGFSCDAYHITAPSSDGAG-AVRAMSAAIKDA--------GI--SV-DDIGYINAHGTSTPIGDEMEINAILKLFNV----D---------------------------------------------------N--RSDMLCVSST-----------------KSLIGHLLGAAGGVEAVVSILSLINNIVHPT-INL-YNPI-IEHK--N-LD------------LIP---------H---K-S----KEVE-------------LKHAMSNSFGFGGTNACLVFSKN---Q---------- 76 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSPTIMAIGAAELALKDSNWH-P-QSET-D-Q--V----------ATGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYSKVSPFFVPKILINMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRLIAHGDADVMVAGGTDSCISPLSLAGFCRARALST--NSDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEVLGYGLSGDAGHITAPDPEGEG-ALRCMTAAVRDA--------NV--HP-EEITYVNAHATSTPLGDAAENKAIKHLFKD-----------------------H--------------------------------A--HA--LAVSST-----------------KGATGHLLGAAGATEAAFTALACYYRKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---R-A----QEWK-------TE--K-RCIGLTNSFGFGGTNATLCIAGI-------------- 77 ------M---------------------------------------F---TPLV-I------INR------------------------------------------------T-LTTA-ARC--KRRVVVTGIGIVCPLGIGVQNAWQAL-INSKSGITKLS--E-PE-----------Y-DKLPCKVGALIPKGT----E--P-NQ-L----NID----SYFSKSELRTMCPATAYALIATEEALNDANWK-P-NDET-D-K--Q----------DTGVAVGIGMIDLVDVCTTY---------------------EA-----LK-K-G-YNKVSPYFVPRILPNMAAGQISIKYGFRGPNHSVSTACATGAHAIGDAFRFIRGGETSVMVCGGAEACISPLAIAAFCRLRALSTSKNDFPYEASRPFDKDRDGFVMGEGAAILVLE-----E------LNHALERKA-K-IYAEVLGYGLSGDAAHLTAPSEDGTG-AILAMDRAVKDA--------GI--ET-VDITFVNAHATSTPLGDAIELKAIESFLG-----Q------------------H--------------------------------S--KN--VTVSST-----------------KGAHGHLLGAAGNLEAIFTILAIKEGIIPPTL-NL-HNLD-M-E-T-N-L-------N-----FVP---------N---V-K----KCWNST---------S-KRVALKNAFGFGGTNACLCFAQYN-K----------- 78 ---------------ML-------------------------------------------G-D--M-------------------------------------------R---TE-M-E-DEQ--DRRVVITGIGLVTPLGVGTQLVWDRL-IQGKSGIVPLV--G-EE-----------Y-KTIPCSVAAYVPRGC----D--E-GQ-F----NEQ----NFVTKSDVKAMSSPTIMAIGAAELALKDSGWH-P-QSEA-D-Q--L----------ATGVAIGMGMVPLEVISETAL--------------------------MFQ-T-KGYNKVSPFFVPKILVNMAAGQVSIRHKLRGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALST--NSDPKLACRPFHPERDGFVMGEGAAVLVLE-----E------REHAVQRGA-R-IYAEILGYGLSGDAGHITAPDPGGEG-AFRCMAAAVKDA--------GV--RP-EEVSYINAHATSTPLGDAAENKAIKRLFKD-----------------------H--------------------------------A--QA--LAVSST-----------------KGATGHLLGAAGAAEAAFTALACYHRKLPPTL-NL-DCTE-P-QF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RCIGLTNSFGFGGTNATLCIAGM-------------- 79 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSPTIMAIGAAELAIKDSGWH-P-QSEA-D-Q--A----------TTGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYNKVSPFFVPKILINMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMLAGSTDSCISPLSLAGFSRARALST--NSDPKLACRPFHPERDGFVMGEGAAVLVLE-----E------HEHAIQRGA-R-IYAEVLGYGLSGDAGHITAPDPEGEG-ALRCMAAAIKDA--------GV--QL-EEISYVNAHATSTPLGDAAENKAIKHLFKD-----------------------H--------------------------------A--SS--LAISST-----------------KGATGHLLGAAGAVEAAFTTLACYYKKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RRIGLTNSFGFGGTNATLCIAGM-------------- 80 -------------------------------------------------------------------------------------------------------------------------ML--RRRVVITGIGLVTPLGVGTQLVWDRL-LLGESGIVSVV--G-DE-----------Y-KSIPCSVAAYVPRGT----G--E-GQ-F----NEQ----NFVSKSDIRAMSSPTILAIAAAGLALKDSGWH-P-KSEA-D-Q--V----------ATGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYNKVSPFFVPKILINMAAGQVSIRYKLKGPNHTVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALST--NPDPKLACRPFHPERDGFVMGEGAAVLVLE-----E------REHAVQRGA-R-MYAEVLGYGLSGDAGHITAPDSEGDG-AFRCMAAAVKDA--------GV--LP-EQISYVNAHATSTPLGDAAENRAIKRLFRD-----------------------H--------------------------------A--GT--LAISST-----------------KGATGHLLGAAGAVEAAFTALACYHQKLPPTL-NL-NCTE-P-EF--D-L----------N--YVP---------L---E-A----QEWK-------TE--G-RCIGLTNSFGFGGTNATLCIAGM-------------- 81 --------M------SA---------LSLSSRTKLQ-LRPH---NIRVLL---Q-KCF-SVSP--N-------------------------------------------QDSRHC-SSG-T-Q--KRRVVITGIGLVCPLGTGTTLPWEHL-IKGHNGIVALT--S-EQ-----------Y-RTIPCRVAALVPRGK----E--P-GQ-F----EEE----KFASRGEINSMCPATVMALGAAQLALEDSGWT-P-TTTE-E-Q--L----------RTGVAVGMGMVSLEEISRTAS--------------------------AFQ-E-KGYKKVSPFFVPRILVNMAAGHISIRHKLKGPNHAVSTACTTGVHAIGDAARFISYGDADAMVAGGAESCVGPLSVAGFSRARALATKWNDDPPKASRPFHPEREGFVMGEGAAVVLLE-----E------REHAVRRGA-R-IYAEILGYGLSGDASHITAPTADGDG-AFRCMSAALRDA--------GV--SP-SDVTYVNAHATSTPLGDAAENAAIKKLFHQ-----------------------S--------------------------------A--EH--LSVSST-----------------KGATGHLLGAAGALEAAFTALSCFHGVLPPTL-NL-DRTD-P-EF--N-L----------N--YVP---------F---T-A----QRWS-------AE--G-RRVALTNSFGFGGTNASLCLSSL-------------- 82 ---------------MF---------LQCSRGLLKI-S---NLHLQSLNL---N-LLL-QN-H--R-------------------------------------------RAFS-K-S-L-PAC--RRKVVVTGIGLVSPLGVGTQFVWKRL-LQGDSGIASLD--G-EE-----------Y-AGVPCKVAACVPRGN----E--E-GQ-F----SEE----SFVSKSEIKSMSSATVMAIGAAELAMKDSSWS-P-QSEQ-D-H--L----------NAGVAIGMGMVPLEEISDTAA--------------------------LFK-T-KGYNKVSPFFVPKILVNMAAGHISIKYQLKGPNHAVSTACTTGAHGVGDSFRFIAAGDADVMLAGGTEACISPLSLAGFSRARALSTSFNSSPKMACRPFDSQREGFVMGEGAAVLVLE-----E------YGHAVRRGA-R-IYAEVLGYGLSGDACHITAPNPEGDG-AFRCMSAAIKDA--------GI--KP-EDITYVNAHATSTPLGDAAENQAIKRLFKD-----------------------H--------------------------------S--RN--IAVSST-----------------KGATGHLLGAAGAIEAAFTALSCYHGVLPPTL-NL-QKTE-A-EF--D-L----------N--YVP---------L---T-A----QEWR-------TE--K-RRIALTNSFGFGGTNATLCFANV-------------- 83 ---------------MI---------SQCSQELLKI-A---NL--QSLKL---N-QYL-RK-H--R-------------------------------------------RAFSTK-S-L-PTC--RRRVVVTGIGLVSPLGVGTQFVWNRL-LQGDSGIASLD--G-EE-----------Y-ASVPCKVAACVPRGN----E--E-GQ-F----SEE----SFVSKSEIKSMSSATVMAIGAAELAIKDADWS-P-QSEQ-D-R--L----------TAGVAIGMGMVPLEEISETAF--------------------------LFK-T-KGYNKVSPFFVPKILVNMAAGQISIKYQLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMLAGGTEASISPLSLAGFARARALSTGFNSRPKMACRPFDSQREGFVMGEGAAVLVLE-----E------YEHAVQRGA-R-IYAEVLGYGLSGDACHITAPNPEGDG-AFRCMSAAIRDS--------GI--KP-EDITYVNAHATSTPLGDAAENQAIKRLFKD-----------------------H--------------------------------A--RH--IAVSST-----------------KGATGHLLGAAGAIEAAFTTLSCYYGILPPTL-NL-QKTE-A-GF--D-L----------N--YVP---------L---T-A----QEWK-------TE--K-RRIALTNSFGFGGTNASLCFASV-------------- 84 --------------------ML----SKCLQHFLKA-T---ISHPY-LAS---Y-SWL-IS-K--H-------------------------------------------RFYGTV-P-A-AML--RRRVVITGIGLVTPLGVGTQLVWDRL-LRGESGIVSVV--G-DE-----------Y-KNIPCSVAAYVPRGP----H--E-GQ-F----NEE----NFVSKSDAKSMSSSTIMAVGAAELALKDSGWH-P-KREA-D-Q--V----------ATGVAIGMGMVPLEVISETAL--------------------------LFQ-T-KGYNKVSPFFVPKILINMAAGQVSIRYKLKGPNHSVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALSS--NPDPKLACRPFHPERDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEILGYGLSGDAGHITAPDPEGEG-ALRCMAAAVKDA--------GV--SP-EQISYVNAHATSTPLGDAAENRAIKRLFRD-----------------------H--------------------------------A--CA--LAISST-----------------KGATGHLLGAAGAVEATFTALACYHQKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---E-S----QEWK-------AE--G-RCIGLTNSFGFGGTNATLCIAGM-------------- 85 ---------------ML---------SNCLQNFLKI-T---STH-LYSRL---C-QRL-TESK--R-------------------------------------------RFFGTV-P-T-SRL--RRRVVITGIGLVTPLGVGTQLVWDRL-IQGESGIVSLV--G-EE-----------Y-KSIPCSVAAFVPRGC----D--E-GQ-F----SEQ----NFVSKSDIKSMSSPTIMAIGASELAMKDSGWH-P-QSEA-D-Q--V----------ATGVAIGMGMIPLEVVSETAL--------------------------MFQ-T-KGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALST--NSDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------LEHAVQRGA-R-IYAEVLGYGLSGDAGHITAPDAEGEG-ALRCMAAAVKDA--------GV--QP-EEISYVNAHATSTPLGDAAENRAIKHLFKD-----------------------H--------------------------------A--YA--LAVSST-----------------KGATGHLLGAAGAVEAAFTTLACYYQKLPPTL-NL-DCTE-S-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RCIGLTNSFGFGGTNATLCIAGM-------------- 86 --------M------SA---------LSLTRWTKLQ-LRAQ---SRRTVL---Q-RIV-SVCP--S-------------------------------------------QDSRRH-SSG-QPQ--RRRVVITGVGLVCPLGTGTALPWDRL-IKGHSGIVALD--S-EE-----------Y-KTIPCKVAALVPRGT----E--E-GQ-F----QGE----NFASRGEINSMSPATVMALGAAQLALEDSGWS-P-KSPE-E-H--L----------STGVAVGMGMVSLDEIARTSS--------------------------AFQ-K-QGYNKVSPFFVPRILVNMAAGHISIKHKLKGPNHAVSTACTTGAHAVGDAARFIAHGDAVAMVTGGTESCVGPLSVAGFARARALATKWNNSPTLASRPFHPEREGFVMGEGAAVLLLE-----E------LEHAVKRGA-R-IYAEVLGYGLSGDASHITAPSADGDG-AFRCMSAALRDS--------GV--SP-SDVTYINAHATSTPLGDAAENAAIKRLFQQ-----------------------S--------------------------------I--EN--LAVSST-----------------KGATGHLLGAAGALEAAFTALACYNGVLPPTL-NL-DRTE-P-EF--N-L----------N--YVP---------C---T-M----QPWR-------TR--G-RRVALTNSFGFGGTNASLCLSSM-------------- 87 --------------------------------------------------------------------------------------------------------------------------------------MKLRTLLMFSHIHIRRY-SQDSRRRVAVT--G----------------------LVGYVPRGD----C--E-GE-F----MAT----KYVSTSEQRTMSEATVFALAATEEALNHAKWK-P-TNNN-D-Q--N----------KTGVAVGMGMVGLNDIVDSGI--------------------------TLR-D-KAYNKVSPYFIPRILVNMAAGHISIRHKLKGPNHAVSTACTTGCHAIGDAMRFIRNGDADIMVAGGTEATVNPLALAGFCRVRALSTKFNDHPEKASRPFHPERDGFVLAEGAAIVILEE-----------YNHAINRGA-T-VLAEILGYGLSGDASHMTAPREDGDG-AIRCMTAAIKDA--------RI--SS-NDVTYVNAHATSTPIGDATENRAIKAVFGN-----------------------H--------------------------------S--NN--IAVSST-----------------KGATGHLLGAAGALESVFTIMACHTGIIPPTV-NL-TEVT-E-EF--D-L----------N--YVP---------C---Q-S----QKWT-------PPSGD-KRIGITNSFGFGGTNASLCIGSV-------------- 88 ------M---------------------------------------F---TPLV-I------INR------------------------------------------------R-LTTA-ARC--KRRVVVTGMGIVCPLGIGVQNAWQAL-INSKSGITKLT--N-PE-----------Y-DKLPCKVA----------------------------------------------------TEEALNDANWK-P-NNET-D-K--R----------DTGVAVGIGMIDLIDVCTTY---------------------EA-----LK-K-G-YNKVSPYFVPRILTNMAAGQISIKYGLRGPNHSVSTACATGAHAIGDAFRFIRGGETSVMICGGAEACISPLAIAAFCRLRALSTNKNDFPYEASRPFDKDRDGFVMGEGAAILVLE-----E------LNHALERKA-N-IYAEVLGYGLSGDATHLTAPSEDGTG-AILAMDRAVKDA--------GI--ET-VEITFINAHATSTPLGDGIELKAIESFMG-----Q------------------H--------------------------------S--KN--VTVSST-----------------KGAHGHLLGAAGNLEAVFTILAIKESVIPPTL-NL-HNLD-T-E-T-S-L-------N-----FAP---------N---I-K----KNWNTT---------S-RRVALKNAFGFGGTNACLCFAQYN-E----------- 89 -------------------------------------------------------------------------------------------------------------------------------------MGIVCPLGIGVQNAWQAL-INSKSGITKLT--N-PE-----------Y-DKLPCKVAALVPKGN----G--P-DE-L----DID----SYFTKSELRTMCPATPYALIATEEALNDANWK-P-NNET-D-K--R----------DTGVAVGIGMIDLIDVCTTY---------------------EA-----LK-K-G-YNKVSPYFVPRILTNMAAGQISIKYGLRGPNHSVSTACATGAHAIGDAFRFIRGGETSVMICGGAEACISPLAIAAFCRLRALSTNKNDFPYEASRPFDKDRDGFVMGEGAAILVLE-----E------LNHALERKA-N-IYAEVLGYGLSGDATHLTAPSEDGTG-AILAMDRAVKDA--------GI--ET-VEITFINAHATSTPLGDGIELKAIESFMG-----Q------------------H--------------------------------S--KN--VTVSST-----------------KGAHGHLLGAAGNLEAVFTILAIKESVIPPTL-NL-HNLD-T-E-T-S-L-------N-----FAP---------N---I-K----KNWNTT---------S-RRVALKNAFGFGGTNACLCFAQYN-E----------- 90 ---------------------------------------------------MIR-P------MSR------------------------------------------------V-ADCK-QMH--VGGGILNRMGIVCPLGIGVQNAWQAL-INSKSGITKLT--N-PE-----------Y-DKLPCKVAALVPKGN----G--P-DE-L----DID----SYFTKSELRTMCPATPYALIATEEALNDANWK-P-NNET-D-K--R----------DTGVAVGIGMIDLIDVCTTY---------------------EA-----LK-K-G-YNKVSPYFVPRILTNMAAGQISIKYGLRGPNHSVSTACATGAHAIGDAFRFIRGGETSVMICGGAEACISPLAIAAFCRLRALSTNKNDFPYEASRPFDKDRDGFVMGEGAAILVLE-----E------LNHALERKA-N-IYAEVLGYGLSGDATHLTAPSEDGTG-AILAMDRAVKDA--------GI--ET-VEITFINAHATSTPLGDGIELKAIESFMG-----Q------------------H--------------------------------S--KN--VTVSST-----------------KGAHGHLLGAAGNLEAVFTILAIKESVIPPTL-NL-HNLD-T-E-T-S-L-------N-----FAP---------N---I-K----KNWNTT---------S-RRVALKNAFGFGGTNACLCFAQYN-E----------- 91 ------M---------------------------------------F---TPLV-I------INR------------------------------------------------R-LTTA-ARC--KRRVVVTGMGIVCPLGIGVQNAWQAL-INSKSGITKLT--N-PE-----------Y-DKLPCKVAALVPKGN----G--P-DE-L----DID----SYFTKSELRTMCPATPYALIATEEALNDANWK-P-NNET-D-K--R----------DTGVAVGIGMIDLIDVCTTY---------------------EA-----LK-K-G-YNKVSPYFVPRILTNMAAGQISIKYGLRGPNHSVSTACATGAHAIGDAFRFIRGGETSVMICGGAEACISPLAIAAFCRLRALSTNKNDFPYEASRPFDKDRDGFVMGEGAAILVLE-----E------LNHALERKA-N-IYAEVLGYGLSGDATHLTAPSEDGTG-AILAMDRAVKDA--------GI--ET-VEITFINAHATSTPLGDGIELKAIESFMG-----Q------------------H--------------------------------S--KN--VTVSST-----------------KGAHGHLLGAAGNLEAVFTILAIKESVIPPTL-NL-HNLD-T-E-T-S-L-------N-----FAP---------N---I-K----KNWNTT---------S-RRVALKNAFGFGGTNACLCFAQYN-E----------- 92 ---------------------------------------------MS---AKLI-H------QIR------------------------------------------------T-I-TQ-SSQ--RRRVVVTGLGVVSPLGTGTELAWQNI-LKGQCGIVSLQ--G-NE-----------Y-SKLPCRVAGLVPLEK----------D-D----KVM----KALSKSNLKSMAPATCLALVATEEALADAKWF-P-KSDI-D-R--E----------STGVAIGMGMIDLKDVCDTN---------------------EA-----LK-I-G-YNKVSPFFVPRILPNMAAGHISIKYGFRGPNHAVSTACATGAHSIGDAFRFIRNGDADVMVCGGAESCISPLAIAGFSRLRALSTSFNDDPGKASRPFDKKRDGFVMGEGAAVLVLE-----E------YQHALERNA-K-MYAEILGYGLSGDASHITAPREDGSG-AVLSMSRALRDG--------CI--DK-EKVTYINAHATSTPIGDGIEATAIKTLFK-----D------------------H--------------------------------S--GN--ILISST-----------------KGAHGHLLGAAGNLEAVFTILSCHQGIIPPTI-NL-EEPV-D-----E-L-------N-----YVA---------K---E-S----KPWTV----------D-RRVALKNSFGFGGTNATLCIGQL-------------- 93 --------------------------------------------------------------------------------------------------------------------------M--KKRVVITGLGAICPAGASKSSSWKNV-LLGKSFVQKLD--S-SL-----------Y-KNIPTKIAATL-D-----------GI-S-----VP----ELIPKHKVRSMAPSTRLALLATHEAVNDSKLF-E-KN---V-D-KE----------NIGVSVGVGMVDLKDVCQMA---------------------ET-----LQ-S-S-YSRVSPYFVPRILLNMAAGQISMEYGIQGPNHAVSTACATGAHAIGDGFRLIQHGEAIAMICGAAESCISPLSIASFCRLRALSTQ-NHTPELASRPFDNKRDGFVIGEGSAILILE-----E------LEHALKRNA-K-IYGEIIGYGMSGDAAHLTAPSENGQG-AYLAMKRSLNDA--------KI--DV-SQVTYINAHATSTPVGDSIELTSINRLFG-----E------------------H--------------------------------S--KN--VYVSST-----------------KGTHGHLLGSAGNLESVFTILACHEGIIPPTA-NL-TDIC-V-EAK-D-L-------I-----CIT---------Q---N-S----VKWRE----------T-KRYALKNAFGFGGTNASLCFTNYV-A----------- 94 -------------------------------------------------------------------------------------------------------------------------------------MGIVCPLGIGVQNAWQAL-INSKSGITKLT--N-PE-----------Y-DKLPCKVAALVPKGN----G--P-NE-L----DID----SYFTKSELRTMCPATPYALIATEEALNDANWK-P-NNET-D-K--R----------DTGVAVGIGMIDLIDVCTTY---------------------EA-----LK-K-G-YNKVSPYFVPRILTNMAAGQISIKYGLRGPNHSVSTACATGAHAIGDAFRFIRGGETSVMICGGAEACISPLAIAAFCRLRALSTNKNDFPYEASRPFDKDRDGFVMGEGAAILVLE-----E------LNHALERKA-N-IYAEVLGYGLSGDATHLTAPSEDGTG-AILAMDRAVKDA--------GI--ET-VEITFINAHATSTPLGDGIELKAIESFMG-----Q------------------H--------------------------------S--KN--VTVSST-----------------KGAHGHLLGAAGNLEAVFTILAIKESVIPPTL-NL-HNLD-T-E-T-S-L-------N-----FAP---------N---I-K----KNWNTT---------S-RRVALKNAFGFGGTNACLCFAQYN-E----------- 95 ------M---------------------------------------F---TPLV-I------INR------------------------------------------------R-LTTA-ARC--KRRVVVTGMGIVCPLGIGVQNAWQAL-INSKSGITKLT--N-PE-----------Y-DKLPCKVAALVPKGN----G--P-NE-L----DID----SYFTKSELRTMCPATPYALIATEEALNDANWK-P-NNET-D-K--R----------DTGVAVGIGMIDLIDVCTTY---------------------EA-----LK-K-G-YNKVSPYFVPRILTNMAAGQISIKYGLRGPNHSVSTACATGAHAIGDAFRFIRGGETSVMICGGAEACISPLAIAAFCRLRALSTNKNDFPYEASRPFDKDRDGFVMGEGAAILVLE-----E------LNHALERKA-N-IYAEVLGYGLSGDATHLTAPSEDGTG-AILAMDRAVKDA--------GI--ET-VEITFINAHATSTPLGDGIELKAIESFMG-----Q------------------H--------------------------------S--KN--VTVSST-----------------KGAHGHLLGAAGNLEAVFTILAIKESVIPPTL-NL-HNLD-T-E-T-S-L-------N-----FAP---------N---I-K----KNWNTT---------S-RRVALKNAFGFGGTNACLCFAQYN-E----------- 96 --------M------WSQSSQHSLVKMSLRCCQK---------MFLRLYG---G-SLS-TAKS--R-------------------------------------------MWLRRY-TKA-AQS--HRRVVITGIGLVSPLGTGSALPWQRL-IAGESGLVALD--P-EE-----------Y-KTVPCKVAARVQRGD----K--Q-GE-F----NEE----AFASKGEINSMSPATVMAIGAAQLALEDCGWY-P-RSPE-E-Q--L----------SAGVAVGMGMVSLEEIARTAL--------------------------AFQ-T-RGYSKVSPFFVPRILVNMAAGHISIKHKLKGPNHAVSTACTTGAHAIGDATRFIAHGDADVMLAGGTEACVSPLSIAGFARARALSTNWNQEPRLASRPFHPDREGFVMGEGAAVLVLE-----E------YGHAEQRGA-R-VYAEVMGYGLSGDASHITAPTADGDG-AFRCMSAALRDA--------GV--SP-SEVTYVNAHATSTPLGDAAENAAIKRLFEQ-----------------------H--------------------------------A--YS--LAVSST-----------------KGATGHLLGAAGALEAAFTALACHHAILPPTL-NL-DRTE-P-EF--D-L----------N--YVP---------C---T-A----QTWR-------TS--G-RRIALTNSFGFGGTNASLCLASV-------------- 97 ------M---------------------------------------S---IPFV-N------ISR------------------------------------------------S-LTTV-ART--KRRVVVTGIGIVSPLGVGTRNAWEAL-IDSKCGITKLI--E-PD-----------Y-NKLPCKIAALVPKGD----A--P-HE-L----NID----SHFTKSELRTMCSGTAYALIASEEALLDAKWT-P-NDEN-D-K--R----------DTGVSVGMGMIDLVDVCTTH---------------------EA-----LK-K-G-YSKVSPYFVPRILTNMAAGQISIKYGFRGPNHAVSTACATGAHAIGDAFRFIRGGETSVMVCGGAEACICPLAIAAFCRLRALSTSRNDTPEKAARPFDRDRDGFVMGEGAAILVLE-----E------LNHALARGV-P-IYAEVLGYGLSGDASHITAPSEDGIG-ALLAMDRTMKDA--------GI--EI-SEITFVNAHATSTPLGDKVEVKAIESLMG-----E------------------H--------------------------------S--KN--VTVTST-----------------KGAHGHLLGAAGNLEAAFTILAIKENVIPPTL-NL-DNLD-M-E-T-C-L-------N-----FAP---------H---T-K----MKWNTM----T----T-RRTALKNAFGFGGTNACLCFAQYV-D----------- 98 --------------------------------------------------------------------------------------------------------------------------M--KKRVVITGMGAICSAGLGKTTCWNNV-LLGKSFVRKLD--S-DL-----------Y-KNIPSKIAATL-D-----------GL-S-----LP----DTIPKSKLRSMAPSTRLALLAAQEAINDSKLF-D-QS---V-D-RE----------NIGVSVGIGMVDLEDVCRTA---------------------KA-----LE-S-S-YSRVSPYFVPRILINMAAGHISMEYGCQGPNHAVSTACATGAHAIGDGFRFIQHGQAVAMICGAAESCISPLSMAAFCRLRALSTQ-NDTPESASRPFDNSRDGFVMGEGSAILILE-----E------LQHALGRNA-Q-IYGEIVGYGMSGDAAHLTSPPVDGQG-AYLAMDRAVRDA--------NI--DK-TQITYVNAHATSTPVGDSIELTAINRLFG-----E------------------H--------------------------------S--KN--IHVSST-----------------KGAHGHLLGSAGNLESVFTVMACDEGVIPPTA-NL-INIC-K-EAE-R-L-------I-----CVS---------E---N-S----VNWRE----------E-KRYALKNAFGFGGTNASLCFSNYV-L----------- 99 -------------------------------------------MAVN--------------RH---------------------------------------------------V--MS-SLS--RSRVVVTGLGLVTCLGVGVDKTWKNL-ISGQCGITQLP--T-KE-----------Y-DKIPCKVAGIVPCGT----K--D-GE-L----NIA----KHFTPTELRGLPLSSAYAMIAAEEALNMAKWK-P-DQEE-E-R--I----------RTGVAIGMGMVSLEEIADVGE--------------------------ALR-G-RGYNRVSPHFIPRILVNMAAGHVSIKHGLKGPNHAVSTACTTGLHAIGDAYSFIQRGVADVMVAGGTEASVSPLSIAGFSRMRALSTKFNNNPQEASRPFDKDRDGFVMSEGCGVVVLE-----E------MNHAINRGA-D-IIAEIQGYGLSGDAHHITSPSEGGDG-AYRCMQTALKDG--------NI--EI-KDIGYINAHATSTPIGDAAESRAIEKLFNN-----------------------E--------------------------------N--KH--LLVSST-----------------KGAVGHLLGAAGSVEAVFTILACQSGKIPPTN-NL-KNSN-T-GC--D-L----------N--YVA---------I---N-S----VPWSA------QF--N-RKIALTNSFGFGGTNGSLCISDFV------------Q 100 --------------------------------------------------MKFL-M------HLR------------------------------------------------K-Y-TQ-FPP--RRRVVVTGVGIVSPLGTGSELAWNNL-LKGNCGIISLK--D-EE-----------Y-SKLPSRVAAIIPIDT----------D-K----EIA----KAMSKSNLKLMAPATCIALVATAEALTDANWI-P-KSDA-D-K--E----------VTGVALGMGMIDLKDVCETN---------------------NA-----LK-L-G-YNKVSPFFVPRILPNMAAGHISIKYGFRGPNHAVSTACATGAHSIGDAFRFIRNGDADVMVCGGAESCISPLAIAGFCRLRALSTSFNDTPEKASRPFDKLRDGFVMGEGAAVVVLE-----E------YEHALRRNA-K-MYAEILGYGLSGDASHITSPREDGSG-AILSMSRALRDS--------NI--KN-EEISYINAHATSTPVGDSIESTAIKTLFK-----E------------------T--------------------------------V--EN--LMVSST-----------------KGAHGHLLGAAGNLEAIWTILACYHGIVPPTI-NL-DEPI-D-----D-L-------N-----YVA---------N---V-P----QKWNK----------E-RRIALKNSFGFGGTNASLCISSI-------------- 101 -------------------------------------M---TRTSGVAQRIINL-R------FPRE-------------------------------------------HRFYS-TVTN-QPS--RRRVVITGTGAVSPLAHNVPEAWSRI-LAGESAISKLS----DQ-----------F-KGLPCQVAAQVLRD-----------Q-L----PTE----KYFSKSDLKIMSTATQFAIIASEEALSSAKLQ-P-NELT-A-EQRE----------RFGVCVGMGMFDLTEVYGAW---------------------QQ-----LQ-R-G-YNRVSPFFVPRLLPNMACGHISMRYGLRGPNHSVSTACATGAHAIGDALRFIRDGDADIILAGSGEACIDPLAIAGFCRLRALSTTHNDAPTASSRPFDKKRDGFVMGEGAAILVLE-----E------LEHARKRGA-P-ILAELLGYGLSGDAYHITSPSEDGTG-ATLAMQRAITDA--------RI--LP-TDITYVNAHATSTPTGDRIEAHAIERVFG-----G------------------H--------------------------------V--SQ--VRVSST-----------------KGAHGHLLGASGNLETVFVVQACVDNKLPPSI-NI-ENLD-E-D-I-K-V-------S-----IVQ---------N---K-S----EQWCNS---AE----V-SRIALKNSFGFGGTNASLCIGEYR------------E 102 -------------------------------------------------------------------------------------------------------------------------MQ--RRRVVVTGIGVLCPLGSTLKESWKNL-IESRCGITKLT--G-PE-----------Y-ETLPCKVAAFVKENG----Q-----K-F----DLS----KHFTKSQLKSMAPATAYALLAANEALTDSNLL-E-LSDE-V-K--F----------KTGVAIGMGMVDLQDVCSTY---------------------EA-----LK-K-G-YHHVSPFFVPRILPNLAGGQISIKYGFKGPNHSVSTACATGAHAIGDSFRFIRDGCADIMVCGGTEACISPLSIAAFCRLRALCTNFNEDPTKSSRPFDKQRDGFVMGEGTAILVLQ-----E------LDSALKHNS-K-IYAEVLGYGLSGDASHLTAPSPDGLG-AFLAMERAVKDA--------QL--DV-SEVSYVNAHATSTPMGDAIEVKAIKKLFD-----N------------------K--------------------------------T--EG--VAVSST-----------------KGAHGHLLGAAGNLEAAFTVKAIEEGVLPPTL-NL-EESE---D-A-G-I-------N-----FVP---------V---R-S----QRWEAR----K----RRRRIALKNAFGFGGTNASLCFAEYK------------- 103 ---------------MF---------SQRSQDLLKI-A---NTHLQRLNL---N-LHL-QN-H--R-------------------------------------------RAFS-K-S-L-PAC--RRKVVVTGIGLVSPLGVGTQFVWKHL-LEGGSGITSLD--G-EE-----------Y-AGIPCRVAACVPRGN----K--E-GQ-F----SEE----SFVSKSEIKSMSSATVMAIGAAELAMKDSGWS-P-QSEQ-D-R--L----------SAGVAIGMGMVPLEEISETAA--------------------------LFK-T-KGYNKVSPFFVPKILVNMAAGHISIKYQLKGPNHAVSTACTTGAHAVGDSFRFIAAGDADVMLAGGTEACISPLSLAGFARARALSTSFNSSPKTACRPFDSKREGFVMGEGAAVLVLE-----E------YGHAVQRSA-R-IYAEVLGYGLSGDACHITAPNPEGDG-AFRCMSAAIKDS--------GI--KP-EDVTYVNAHATSTPLGDAAENQAIKRLFKD-----------------------H--------------------------------S--RN--IAVSST-----------------KGATGHLLGAAGAIEAAFTALSCYHGILPPTL-NL-EKTE-A-EF--D-L----------N--YVP---------L---T-A----QEWK-------SE--K-RRIALTNSFGFGGTNATLCFASV-------------- 104 ------MIK------GQ---------GLNSMHCVRR-H---IAALIR---Q--Q-H------RSL------------------------------------------------QTQ-HT-KDR--RRRVVITGLGVVSPVGCNVTTAWQTI-LSGQSKVGRLI--G-DA-----------Y-EKLPCRVAATIDKQ-----------D-V----DLE----QSFPKSELKTMARSTAFALLAAKEALTAASWT-P-SVED-E-IACQ----------RTGVAVGMGMVDLQDICETN---------------------EA-----LK-K-G-YNRVSPFFVPRILPNMPAGQLSIKYGFRGPNHAVSTACATGAHSIGDAFRFIRNGDADVMVCGGAEACINPLAIAGFCRLRALSTAFNDDPTASSRPFDEHRDGFVMGEGSAIFVLE-----E------LEHARSRGA-P-IQGEILGYGLSGDASHLTAPREDGTG-AKLAMTRALNDA--------NL--TI-GEVGYINAHATSTPIGDAIEARSIRTLFG-----D------------------H--------------------------------A--DK--VAVSST-----------------KGAHGHLLGAAGNLEAMFTVLACRHGVLPPTV-NL-GSIT-D-DMA-G-L-------R-----FVA---------K---N-S----EPWDD-----G----RR-RVALKNSFGFGGTNACLCIGEYQ------------E 105 ------MGS------NI---------HSYCFLRARK-S---LFFLLR---S-QY-Q------SPG------------------------------------------------ARY-ST-KSG--DRRVVVTGLGVVSPVGCDVETAWRTI-LSGQSKIGRLA--G-ET-----------Y-DKLPCRVAATIHTD-----------Q-I----DLE----KCFSKTELKTMARATAFALIAAKEALSMAGWT-P-PNED-E-ESCQ----------RTGVAIGMGMVDLMDICETN---------------------EA-----LK-K-G-YNRVSPFFVPRILPNMPAGQLSIRYGFRGPNHAVSTACATGAHAIGDAFRFIQHGDADVMVCGGAEACISPLGIAGFCRLRALSTAFNDEPTASSRPFDERRDGFVMGEGSAIFVLE-----E------LQHAKRRGA-P-IYGEILGYGLSGDASHLTAPREDGTG-ALLAMRRAIADA--------GK--TV-ADIGYVNAHATSTPIGDAIEARSIRTLFG-----E------------------H--------------------------------I--RS--VAVSST-----------------KGAHGHLLGAAGNLEALFVLMACKHGVLPPTV-NL-HNVT-D-DMA-G-L-------H-----YVA---------N---S-S----EPWEG-----N----RR-RIALKNSFGFGGTNACLCIGEYS------------E 106 --------------------------------------------------------------------------------------------------------------------------M--KKRVVITGMGVVCPAGANRHISWKNI-LLGKSFVRKLD--S-DL-----------Y-KNVPSKIAATL-D-----------GL-E----DLP----DTVPKSKVRTMAPSTRLALIAAQEAVDDSKIF-L-ST---V-D-KE----------NIGVSVGVGMVDLEDVCQTA---------------------KA-----LE-I-S-YSKVSPYFVPRILLNMAAGQISMAYGIQGPNHAVSTACATGAHAIGDGFRFIQYGQAKAMICGAAESCISPLSLASFCRIRALSTQ-NDKPELASRPFDVNRDGFVIGEGSAMIILE-----E------LEHAINRNA-H-IYGEVLGYGLSGDASHLTAPPENGQG-ALLAMTRAILDA--------KV--DK-NKITYVNAHATSTPVGDAIELTAIKRLFD-----E------------------H--------------------------------C--NN--VHVSST-----------------KGSHGHLLGSAGNLESIFTILACHEGIIPPTA-NL-NNIC-K-EAE-N-L-------I-----CVS---------K---G-P----IEWKQ----------E-KRIAIKNAFGFGGTNASLCFSNFI-F----------- 107 ------MP-----------------------------------LQMP---VWRQ-LGR-PVSD-L---------------------------------------------GRRG-ISSS-CGK--QRRVVVTGLGMVTPLGADAKTSWSRL-IQSQSGISRLG----K-E----------F-DGIPSKTAGRVPTDAS--QN--P-SP-F----DVH----KFVSKSELRSTSLATAYALAAAKEALDDAQWH-P-DSDT-D-C--R----------TTGVAIGNCMCDLEYVVDTG---------------------MA-----LR-E-QGFKKISPFFVPRILTNMPSGLVSIQHKLKGPNHSVATACTTGVHAIGDALSFIQRGYADVMVCGGTEASVSPMCVAAFARMRALST--AEDPAAASRPFDKNRDGFVVAEGCSILILE-----E------LEHAIARGA-N-IHAEVLGYGLSGDAFHITAAANDGAG-AFACMESALRNA--------RV--NV-QEVGYVNAHATSTPIGDAAEALAIRRLLG-----D------------------N--------------------------------F--NK--VAVSAT-----------------KGSTGHLLGAAGATESAFTVLAVRDGVIPPTL-NL-ECPD-V-G-A-D-L-------N-----FVA---------H---Q-S----APWRTE---NA----T-RRVAIKNSFGFGGTNGSLVIAEYR------------Q 108 ---------------ML---------SNGLQKFLKA-T---GSPPH-PAS---Y-CWL-IS-K--R-------------------------------------------QSSGAL-P-A-ATS--RRRVVITGIGLVTPLGVGTQLVWDRL-LRGESGIVSVV--G-EE-----------Y-KSIPCSVAAYVPRGT----E--E-GQ-F----NEQ----NFVSKSDTKSMSSPTIMAIGAAELALKDSGWH-P-KLEA-D-Q--V----------ATGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYNKVSPFFVPKILINMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDACISPLSLAGFSRARALST--NPDPKLACRPFHPERDGFVMGEGAAVLVLE-----E------HAHALQRGA-R-IYAEVLGYGLSGDAGHITAPDSEGEG-AFRCMAAAVKDA--------GV--LS-EQISYVNAHATSTPLGDAAENRAIKRLFRD-----------------------H--------------------------------A--GA--LAVSST-----------------KGATGHLLGAAGAAEAAFTALACYHQKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---E-A----QEWK-------PQ--G-RRIGLTNSFGFGGTNATLCIASM-------------- 109 ------ML--------------------------W------RIQRIK---VTSS-A------MVS------------------------------------------------F-QQYS-TTK--RRRVVVTGIGVVSPLGCGAQHAWNRI-LSGDCGIVRLP--D-DR-----------Y-GTLPCKIAGLVKKGN----S--D-GE-L----NIN----LHFADRELRTMAPATVYAMVAAKEALEDANWF-P-EEEE-M-K--Q----------QTGVAIGMGMVDMEDICSTN---------------------ES-----LK-R-G-YNRVSPYFVPRILVNMAAGLISIRYGFKGPNHAVSTACATGAHAIGDAYRFIQHGDAKVMVCGATEASVNPLSIAGFCRLRALSTKFNDEPLKASRPFDKNRDGFVMGEGSAVIILE-----E------LDHAIQRGA-Q-IYAEVLGYGLSGDASHLTAPNEDGLG-ATLAMSRAIYDA--------RL--QP-EEISYVNAHATSTPLGDEIEAKAISRLLG-----K------------------H--------------------------------G--G---VAVSST-----------------KGAHGHLLGAAGNLESVFTIMAIKTGFLPPSI-NI-ENAI-D-A-K-N-V-------H-----FVS---------N---I-K----REWNHQ---------K--RIALKNAFGFGGTNVSLCFSQYV-S----------- 110 ---------------------------------------------MR---TNLI-S------QVR------------------------------------------------S-L-SQ-FPP--RRRVVVTGLGVVAPLGSGTEVVWQKL-LQGGSGIVPLQ--G-EE-----------Y-SKLPCKVAGLIPK------------D-D----TVT----KALSKSNLRSMAPATCLALVATAEALTDAKWL-P-ETEA-D-K--E----------VTGVALGMGMIDLKDVCDTN---------------------DA-----LK-S-G-YNKVSPFFVPRILPNMAAGQISIKYGFRGPNHAVSTACATGAHSIGDAFRFIRNGDADVMVCGGAEACISPLAIAGFCRLRALSTSFNDNPTKASRPFDKKRDGFVMGEGAAVLVIE-----E------HEHAVKRNA-K-IYAEILGYGLSGDASHITSPREDGSG-AILSMSRAIRDS--------NI--EK-EQITYINAHATSTPIGDGIESTAIKTLFG-----Q------------------H--------------------------------S--SK--ISISST-----------------KGAHGHLLGAAGNLEAVFTILACHHGVIPPTL-NL-EEPV-D-----N-L-------D-----YVA---------N---D-P----RKWET----------K-RRVALKNSFGFGGTNATLCIAQI-------------- 111 --------M------SP---------LS-SCWTRLQ-LSTL---NFRALL---H-KTV-CVCP--K-------------------------------------------PDSRHH-SCG-Q-H--RRRVVITGIGLVCPLGTGTAVAWDHL-IKGQSGIVALP--S-EE-----------Y-KTVPCKVAALVPRGN----E--P-GQ-F----KEE----RFTSRGQINSMSPATVMALGAAQLALEDSGWY-P-ETTE-E-Q--L----------NTGVAVGMGMVSLDEIARTSA--------------------------AFQ-E-KGYSKVSPFFVPRILVNMAAGHISIKHNLKGPNHAVSTACTTGAHAIGDAARFIAHGDAVAMVTGGTESCVGPLAMAGFARARALATKWNDNPTQASRPFHPEREGFVMGEGAAVLLLE-----E------LDHAVKRGA-R-IYAEVLGYGLSGDASHITAPTADGDG-AFRCMSTALRDA--------GV--SP-ADVTYVNAHATSTPLGDAAENAAIKRLFQQ-----------------------S--------------------------------V--EN--LAVSST-----------------KGATGHLLGAAGALEAAFTALACYHGVLPPTL-NL-DRTE-P-EF--D-L----------N--YVP---------C---T-A----QQWQ-------TQ--G-RRVALTNSFGFGGTNASLCLSSM-------------- 112 --------------------------------------------------------------------------------------------------------------------------M--HRRVVVTGIGVLSPVGANLKESWKNI-INGKSGITKLL--G-PE-----------Y-EHLPCKVAGFVKTDG----A-----K-F----DIA----ARFSPSELKSMGPATAFALLAAEEALTDAGLT-Q-ASEE-T-R--N----------NIGVAVGMGMVDLQDICKTY---------------------DA-----LK-K-G-YHQVSPFFVPRILPNMAAGQISIKYGFRGPNHAVSTACATGAHAIGDSFRFVRNGDADVMICGGTESCISPLAIAGFCRLRALSTHFNEEPEKASRPFDNKRDGFVMGEGSSILVLE-----E------LEHALNRQA-N-IYAEILGYGLSGDASHLTAPRSDGTG-AHLAMSRAVKDA--------KV--DV-SDISYVNAHATSTPIGDAIEVKAISQLFG-----D------------------R--------------------------------V--KN--IAISST-----------------KGAHGHLLGAAGNLEAVFTIKAVQEGILPPTI-NH-EAVD---L-K-D-I-------N-----FVP---------N---N-N----QKWNDN----G----KR-RIALKNAFGFGGTNACLCIAEYQ------------G 113 ------ML--------------------------W------RIQKIK---VTSS-A------MVS------------------------------------------------F-QQYS-TTK--RR-VVVTGIGVVSPLGCGAQHAWNRI-LSGDCGIVRLP--D-DR-----------Y-GTLPCKIAALVKKGN----S--D-GE-L----NIN----LHFADRELRTMAPATVYALVAAKEALEDANWF-P-EEEE-M-K--Q----------QTGVAIGMGMVDMEDICSTN---------------------ES-----LK-R-G-YNRVSPYFVPRILVNMASGLISIRYGFKGPNHAVSTACATGAHAIGDAYRFIQHGDAKVMVCGATEASVNPLSIAGFCRLRALSTKFNDEPLKASRPFDKNRDGFVMGEGSAVIILE-----E------LDHAIQRGA-Q-IYAEVLGYGLSGDASHLTAPNEDGLG-ATLAMSRAICDA--------RL--QP-EEISYVNAHATSTPLGDEIEAKAISRLLG-----K------------------H--------------------------------G--G---VAVSST-----------------KGAHGHLLGAAGNLESVFTIMAIKTGFLPPSI-NI-ENAI-D-A-K-N-V-------H-----FVS---------N---I-K----REWNHQ---------K--RIALKNAFGFGGTNVSLCFSQYV-S----------- 114 ------ML--------------------------W------RIQRIK---VTSS-A------MVS------------------------------------------------F-QQYS-TTK--RRRVVVTGIGVVSPLGCGAKHAWNRI-LSGECGIVRLP--D-DR-----------Y-GTLPCKIAALVKKGN----S--D-GE-L----NIN----LHFADRELRTMAPATVYAMVAAKEALEDANWF-P-EEEE-M-K--Q----------QTGVAIGMGMVDMEDICSTN---------------------ES-----LK-R-G-YNRVSPYFVPRILVNMAAGLISIRYGFKGPNHAVSTACATGAHAIGDAYRFIQHGDAKVMVCGATEASVNPLSIAGFCRLRALSTKFNDEPLKASRPFDKNRDGFVMGEGSAVIILE-----E------LDHAIQRGA-Q-IYAEVLGYGLSGDASHLTAPNEDGLG-ATLAMSRAICDA--------RL--QP-EEISYVNAHATSTPLGDEIEAKAISRLLG-----K------------------H--------------------------------G--S---VAVSST-----------------KGAHGHLLGAAGNLESVFTIMAIKTGFLPPSI-NI-ENAI-D-A-K-N-V-------H-----FVS---------N---I-K----REWNHQ---------K--RIALKNAFGFGGTNVSLCFSQYV-S----------- 115 ------ML--------------------------W------RIQRIK---VTSS-A------MVS------------------------------------------------F-QQYS-TTK--RRRVVVTGIGVVSPLGCGAQHAWNRI-LSGDCGIVRLP--D-DR-----------Y-GTLPCKIAALVKKGN----S--D-GE-L----NIN----LHFADRELRTMAPATVYAMVAAKEALEDANWF-P-EEEE-M-K--Q----------QTGVAIGMGMIDMEDICSTN---------------------ES-----LK-R-G-YNRVSPYFVPRILVNMAAGLISIRYGFKGPNHAVSTACATGAHAIGDAYRFIQHSDAKVMVCGATEASVNPLSIAGFCRLRALSTKFNDEPLKASRPFDKNRDGFVMGEGSAVIILE-----E------LDHAIQRGA-Q-IYAEVLGYGLSGDASHLTAPNEDGLG-ATLAMSRAICDA--------RL--QP-EEISYVNAHATSTPLGDEIEAKAISRLLG-----K------------------H--------------------------------G--G---VAVSST-----------------KGAHGHLLGAAGNLESVFTIMAIKTGFLPPSI-NI-ENAI-D-A-K-N-V-------H-----FVS---------N---I-K----REWNHQ---------K--RIALKNAFGFGGTNVSLCFSQYV-S----------- 116 ----------------M---------SYHLQNFLKI-T---SHHLLYSRL---C-QQL-RS----K-------------------------------------------RFFGTVPT-T-ASL--RRRVVITGIGLVTPLGMGTQLVWDRL-IRGESGIVSLV--G-EE-----------Y-KSIPCTVAAYVPRGC----D--E-GQ-F----NEQ----NFVSKSDIKSMSSPTIMAIGAAELALEDSGWC-P-QSEA-D-Q--V----------ATGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRLIAHGDADVMVAGGTDSCISPLSLAGFSRARALSM--NSDPKLACRPFHPERDGFVMGEGAAVLVLE-----E------HGHAVQRGA-R-IYAEILGYGLSGDATHITAPDPGGEG-ALRCMAAAVRDA--------GV--RP-EEISYVNAHATSTPLGDAAENKAIKRLFRD-----------------------H--------------------------------A--YA--LAVSST-----------------KGATGHLLGAAGAVEAAFTALACYYRKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-T----QEWN-------TE--K-RCIGLTNSFGFGGTNATLCIAGM-------------- 117 ---------------------------------------------MS---GRII-N------QIR------------------------------------------------T-I-TQ-SPH--KRRVVVTGLGVVSPLGTGTELVWQNI-LKGQCGIVALP--G-LE-----------Y-SKLPCRIAGLIPSEK----------D-D----VVA----KALSKSNLKSMAPATCLALVATAEALADAKWS-P-TSEH-D-K--E----------ATGVAIGMGMIDLKDVCDTN---------------------DA-----LK-V-G-YNKVSPFFVPRILPNMAAGHISIKYGFRGPNHAVSTACATGAHSVGDAFRFIRNGDADVMVCGGAEACISPLAIAGFSRLRALSTSFNDNPTKASRPFDKKREGFVMGEGAAILVLE-----E------YQHALDRKA-K-IYAEILGYGLSGDASHITAPRDDGSG-AVLSMKRALRDG--------CI--DT-DKITYINAHATSTPVGDGIEATAIKTLFQ-----D------------------H--------------------------------S--SN--ILVSST-----------------KGAHGHLLGAAGNLEAIFTILACHHGVIPPTI-NL-EEPV-D-----D-L-------N-----YVA---------N---E-S----KPWNA----------D-RRIALKNSFGFGGTNATLCIGQM-------------- 118 ---------------ML---------SNGLQSCLKF-T---SAHLIHTRS---C-QRL-IS-E--R-------------------------------------------RFFGTV-P-T-PRL--RRRVVVTGIGLVTPLGVGTQLVWDRL-IQGESGIVSLV--G-EE-----------Y-KSVPCSVAAYVPRGC----N--E-GQ-F----NAQ----NFVPKSDIKSMSSPTVMAIGAAELALKDSGWH-P-QSEA-D-Q--A----------ATGVAIGMGMVPLEEISETAL--------------------------MFQ-T-KGYSKVSPFFVPKILISMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSLRFIAHGDADVMVTGGADSCISPLSLAAFSRARALST--NSDPKSACRPFHPKRDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEILGYGLSGDASHITAPDPGGEG-ALRCMAAALKDA--------GV--QP-EEISYINAHATSTPLGDAAENKAIKHLFKE-----------------------H--------------------------------A--HA--LAVSST-----------------KAATGHLLGAAGAAEAAFTSLACYHRKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RCIGLTNSFGFGGTNATLCIAGM-------------- 119 ---------------MF---------SQCSQDLLTM-A---NLHLRSLNL---N-LHL-RN-H--R-------------------------------------------RAFS-K-S-L-PAC--RRKVVVTGIGLVSPLGVGTQFVWKRL-LQGDSGIASLD--G-EE-----------Y-AGVPCKVAACVPRGN----K--E-GQ-F----SEE----SFVSKSEIKSMSSATVMAIGAAELAMKDSGWS-P-QSEQ-D-R--L----------SAGVAIGMGMVPLEEISDTAA--------------------------LFK-T-KGYNKVSPFFVPKILVNMAAGQISIKYQLKGPNHAVSTACTTGAHAVGDSFRFIAAGDADVMLAGGTEACISPLSLAGFARARALSTSFNSSPKMACRPFDSQREGFVMGEGAAVLILE-----E------YEHAVQRGA-R-IYAEVLGYGLSGDACHITAPNPEGDG-AFRCMSAAIKDS--------GI--KP-EDITYVNAHATSTPLGDAAENQAIKRLFKD-----------------------H--------------------------------S--CN--IAVSST-----------------KGATGHLLGAAGAIEAAFTALSCYHGILPPTL-NL-EKTE-A-EF--D-L----------N--YVP---------L---T-A----QEWK-------TE--K-RRIALTNSFGFGGTNATLCFASV-------------- 120 ---------------MF---------LSRTYWAKQR----P---SGRILF---E-RNP-STCP--S-------------------------------------------QQSFRW-YSP-G-R--RRRVVITGIGIVCPLGTGTALPWNNI-IKGQSGIVALC--S-EE-----------Y-RTIPCKVAALVPRGN----A--E-GQ-F----NEQ----MFASRGELRSMSPATVMALGAAQLALDDSGWY-P-ETTE-D-Q--L----------ATGVNVGMGMVSLDEIVSTSA--------------------------AFH-Q-KGYKKMSPFFVPRILVNMAAGHISIKHHLKGPNHAVSTACTTGAHAIGDAARFIAHGDAVAMVTGGTESCVGPLSIAGFARARALATKWNECPKLASRPFHPERDGFVMGEGSAVLLLE-----E------LEHALKRGA-T-MYAEVLGYGLSGDASHITTPAADGDG-AFRCMSAAIKDA--------GI--SP-GDVSYVNAHATSTLLGDAAENAAIKRLFRQ-----------------------S--------------------------------A--GA--LAVSSV-----------------KGATGHLLGAAGALETAITALACYHGVLPPTL-NL-DRTQ-P-EF--N-L----------N--YVP---------C---V-A----QPWQ-------TS--G-RRVALSNSFGFGGTNATLCIANI-------------- 121 ---------------ML---------SGCLQNFLKV-T---NPHPQYSRL---W-Q-L-RMHK--R--------------------------------------------FLGNI-S-T-SRS--RRRVVITGIGLVTPLGVGTQLVWDRL-LQGASGIVSLV--G-EE-----------Y-KNIPCSVVAYVPRGS----D--E-GQ-F----NEQ----NFVSKSDIKSMSSPTIMAIGAAELAMKDSNWH-P-ESEA-D-Q--V----------STGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYNKVSPFFVPKILINMAAGQISIRHKLKGPNHAVSTACTTGAHAVGDSFRFIAQGDADVMVAGGTDSCISPLSLAGFARARALST--NSDPKLACRPFHPKRDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEVLGYGLSGDAGHITAPDPEGEG-ALRCMAAAVKDA--------GV--QP-EEITYVNAHATSTPLGDAAENKAIKHLFKD-----------------------H--------------------------------A--RA--LAVSST-----------------KGATGHLLGAAGAAEAAFTALACYYRKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-T----QDWE-------SE--K-RRIALTNSFGFGGTNATLCIAGI-------------- 122 ------MP-----------------------------------IQIS---IWRQ-LCR-PVSD-L---------------------------------------------GRRG-ISSS-SDK--PKRVVVTGLGMVTPLGADAKTSWSQL-IQSQSGISRLG----K-E----------F-DGIPSKIAGRVPTDSS--QN--P-SP-F----DVH----KFVSKSELRNISMAAAYALAAAKEALDDAQWH-P-DSDA-D-C--R----------ATGVAIGNCMCDLEYVIDTG---------------------MA-----LR-E-QGFKKLSPFFVPRILTNMPSGLVSIQHKLKGPNHSVATACATGVHAIGDAFSFIQRGYADVMVCGGTEASVSPISVAAFARMKALST--AEDPATASRPFDKNRDGFVVAEGCSILILE-----E------LEHAIARGA-K-IYAEVLGYGLSGDAFHITAAANDGAG-AFACMESALRNA--------RV--NV-QEVGYVNAHATSTPIGDAAEAAAIRRLLG-----D------------------N--------------------------------F--SK--VAVSAT-----------------KGSTGHLLGAAGATESAFTVLAVRDGVIPPTL-NL-ECPD-V-G-A-D-L-------N-----FVT---------H---Q-S----APWRTE---NA----T-RRVAIKNSFGFGGTNGSLVIAEYR------------K 123 ------MIK------GQ---------GRYSLHCARR-Y---TAALIR---Q--Q-H------RSF------------------------------------------------QTQ-QT-KDR--RRRVVITGLGVVSPVGCNVTTAWQTI-LSGQSKVGRLI--G-DA-----------Y-EKLPCRVAATIDKQ-----------D-I----DLE----QSFTKSELKTMARGTAFALLAAKEALTAASWT-P-STED-E-SACQ----------RTGVAVGMGMVDLQDICDTN---------------------EA-----LK-K-G-YNRVSPFFVPRILPNMPAGQLSIKYGFRGPNHAVSTACATGAHSIGDAFRFIRNGDADVMVCGGAEACINPLAIAGFCRLRALSTAFNEDPTASSRPFDEHRDGFVMGEGSAIFVLE-----E------LEHARNRGV-P-IQGEILGYGLSGDASHLTAPRDDGTG-AMLAMTRALNDA--------NL--TT-AEVGYINAHATSTPIGDAIEARSIRTLFG-----D------------------H--------------------------------T--DK--VAVSST-----------------KGAHGHLLGAAGNLEALFTLLACRHGVLPPTV-NL-DSIT-D-DMA-G-L-------R-----FVA---------K---T-S----EPWDD-----G----RR-RVALKNSFGFGGTNACLCIGEYQ------------E 124 ---------------ML---------SNCLQNFLKI-T---SPH-LYSRL---C-QQL-IGNK--R-------------------------------------------RFFGTV-P-T-SRI--RRRVVITGIGLVTPLGVGTQLVWDRL-IRGESGIVSLV--G-EE-----------Y-KSIPCSVAALVPRGC----A--D-GQ-F----NEQ----NFVSRSDIKSMSSPTIMAIGAAELAMKDSDWR-P-QSEA-D-R--V----------ATGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYSKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGADSCISPLSLAGFSRARALST--NSDPKLACRPFHPKRDGFVMGEGAAVMVLE-----E------HDHAVQRGA-R-IYAEVLGYGLSGDAGHITAPDPEGEG-ALRCMAAAVKDA--------SV--QP-EDISYVNAHATSTPLGDAAENKAIKHLFKD-----------------------H--------------------------------T--RA--LAVSST-----------------KGATGHLLGAAGAVEAAFTALACYYQKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------IE--K-RRIGLTNSFGFGGTNATLCIAAM-------------- 125 -----MMGP------NA---------HSYCLLRARK-S---LPYVLR---T--I-H------QSH------------------------------------------------SKH-TR-DSG--RRRVVVTGLGVVSPVGCNVEAAWQTI-LSGQSKVGRLV--G-ET-----------Y-DKLPCRVAATIDTN-----------D-I----DLE----KCFSKTELKTMARATAFALIAAKEALSRASWM-P-GVED-E-TACQ----------RTGVAIGMGMVDLMDICETN---------------------EA-----LK-K-G-YNRVSPFFVPRILPNMPAGQLSIRYGFRGPNHAVSTACATGAHAIGDAFRFIQHGDADVMVCGGAEACISPLGIAGFCRLRALSTAFNDEPTASSRPFDERRDGFVMGEGSAIFVLE-----E------LQHALRRGA-P-IYGEILGYGLSGDASHLTAPREDGTG-ALLAMQRALADG--------GV--TV-ADIGYVNAHATSTPIGDAIEARAIRTLFG-----E------------------H--------------------------------T--RS--LAVSST-----------------KGAHGHLLGAAGNLEALFVVMACRHGLLPPTV-NL-QNVT-D-DMA-G-L-------H-----YVA---------N---S-S----EPWEGK----H----RR-RVALKNSFGFGGTNACLCIGEYS------------E 126 --------M------SP---------LS-SCWTRLQ-LSTL---NFRALL---H-KTV-CVCP--K-------------------------------------------PDSRHH-SCG-Q-H--RRRVVITGIGLVCPLGTGTAVAWDHL-IKGQSGIVALP--S-EE-----------Y-KTVPCKVAALVPRGN----E--P-GQ-F----KEE----RFTSRGQINSMSPATVMALGAAQLALEDSGWY-P-ETTE-E-Q--L----------NTGVAVGMGMVSLDEIARTSA--------------------------AFQ-E-KGYSKVSPFFVPRILVNMAAGHISIKHKLKGPNHAVSTACTTGAHAIGDAARFIAHGDAVAMVTGGTESCVGPLAMAGFARARALATKWNDNPTQASRPFHPEREGFVMGEGAAVLLLE-----E------LDHAVKRGA-R-IYAEVLGYGLSGDASHITAPTADGDG-AFRCMSTALRDA--------GV--SP-ADVTYVNAHATSTPLGDAAENAAIKRLFQQ-----------------------S--------------------------------V--EN--LAVSST-----------------KGATGHLLGAAGALEAAFTALACYHGVLPPTL-NL-DRTE-P-EF--D-L----------N--YVP---------C---T-A----QQWR-------TQ--G-RRVALTNSFGFGGTNASLCLSSM-------------- 127 --------------------------MSVTCWQKLSVKHLSRALCIRTCT---S-VLE-TSRR--K-------------------------------------------YSHLSH-SST-AQS--PRRVVITGIGLVSPLGTGTALPWQRL-VDGESGIVALD--S-EE-----------Y-RTVPCKVAARVPRGD----G--E-GE-F----KEE----RFVGRGEMSCMSSATVMAVGAAHLALEDCGWY-P-RSPE-E-Q--L----------NTGVAVGMGMVSLEEIARTAA--------------------------AFE-T-RGYSKVSPFFVPRILVNMAAGHISIKHKLKGPNHAVSTACTTGAHAVGDAARFIAHGDAVVMVAGGTEACVSPLSIAGFARARALSTNWNQQPKLASRPFHPEREGFVMGEGAAVLILE-----E------YRHAMERGA-R-VYAEVLGYGLSGDASHITAPTEDGDG-AFRCMSAALRNA--------GV--SP-SDVTYVNAHATSTPLGDAAENASIKKLFQK-----------------------Q--------------------------------S--PL--LAVSST-----------------KGATGHLLGAAGALEAAFTALACYHGILPPTL-NL-DRTE-P-EF--D-L----------N--YVP---------C---V-S----QPWS-------TD--G-PRIALTNSFGFGGTNASLCLTSV-------------- 128 -------------------------------------M---TRTSGVAQRIINL-R------FPKE-------------------------------------------HRFYS-TVTN-QLS--RRRVVITGTGAVSPLAHNVPEAWSRI-LAGESAISKLG----DQ-----------F-KGLPCQVAAQVLRD-----------Q-L----PTE----KYFSKSDLKIMSTATQFAIIASEEALSSAKLQ-P-KDLT-A-KQRE----------RFGVCVGMGMFDLTEVYGAW---------------------QQ-----LQ-R-G-YNRVSPFFVPRLLPNMACGHISMRYGLRGPNHSVSTACATGAHAIGDALRFIRNGDADIILAGSGEACIDPLAIAGFCRLRALSTTHNDTPMASSRPFDKKRDGFVMGEGAAILVLE-----E------LEHARNRGA-P-ILAELLGYGLSGDAYHITSPSEDGTG-ATLAMQRAITDA--------RI--LP-TDITYVNAHATSTPTGDRIEAHAIERVFG-----E------------------H--------------------------------V--SK--VRVSST-----------------KGAHGHLLGASGNLETVFVVQACVDNKLPPSI-NI-ENLD-E-D-I-K-V-------S-----IVQ---------N---K-S----EQWCNS---AE----V-LRIALKNSFGFGGTNASLCIGEYR------------E 129 ------MAS------HS---------YSYCFQRVRK-S---LFLLLR---SRDH-I------LSN------------------------------------------------AKY-ST-NSG--RRRVVVTGLGVVSPVGCNVETAWQTI-LSGQSKISRLV--G-EQ-----------Y-DKLPCRVAATIDTN-----------H-I----DLE----KCFSKTELKTMARATAFALIAAKESLTMAAWT-P-PIDD-E-ESCQ----------RTGVAIGMGMVDLMDICETN---------------------EA-----LK-K-G-YNRVSPFFVPRILPNMPAGQLSIRYGFRGPNHAVSTACATGAHAIGDAFRFIQHGDADVMVCGGAEACISPLAIAGFCRLRALSTAFNDEPMASSRPFDERRDGFVMGEGSAIFVLE-----E------LEHAKRRGA-Q-IYAEILGYGLSGDASHLTAPREDGTG-ALLAMRRAIADA--------GQ--TV-ADIGYINAHATSTPIGDAIEARSIRTLFG-----D------------------H--------------------------------T--ES--VAVSST-----------------KGAHGHLLGAAGNLEALFVVMACRQGVLPPTV-NL-QKVT-D-DMA-G-L-------H-----YVA---------N---R-S----EPWEG-----N----RR-RIALKNSFGFGGTNACLCIGEYG------------E 130 ------MP-----------------------------------LQTS---VWRQ-LGR-PVSDLI---------------------------------------------GRRG-ISNS-RDK--PKRVVVTGLGMVTPLGADAKTSWSRL-TQSHSGISRLG----K-E----------Y-DGIPSRVAGRVPTDAS--QN--P-SP-F----DVH----KFVSKSELRSTSLATAFALSATKEALDDAQWH-P-DSEV-D-C--R----------ATGVAIGNCMCDLEYVVDSG---------------------MA-----FR-E-KGYSKISPFFIPRILTNMPTGIISIQHKLKGPNHSVATACTTGVHAIGDAFSFIQRGYADVMVCGGAEASISPIGVAAFARMRALST--AEDPAKASRPFDKNRDGFVVAEGSSILVLE-----D------LEHAIARGA-N-IHAEILGYGLSGDAFHITAASTDGDG-AFACMESALKNA--------GV--DI-QDVGYVNAHATSTPVGDAAEAAAIRGILG-----D------------------Y--------------------------------C--SK--VAVSAT-----------------KGSTGHLLGAAGATESAFTVLAVRDGVIPPTL-NL-DCPD-V-G-A-D-L-------N-----FVA---------H---Q-S----RPWPTE---NT----T-RRVAIKNSFGFGGTNGSLVIAEYR------------K 131 --------M------HV---------FLLSRWENLL-MKLP--RSKFLDA---K-AFM-CINS--H-------------------------------------------VRPFSA-PPP-ARS--RRRVVITGIGLVCPLGIGTTLPWERL-IRSGSGIISLD--P-EE-----------Y-RTVPCKVAACVPRGD----G--D-GE-F----KEE----RFASRAEIGSMSPASVMALAAADLALKDSGWY-P-TSPE-E-Q--L----------STGVAVGMGMVPLDEISRTAS--------------------------VFQ-S-KGYNKVSPFFVPRILVNMAAGHISIRHRLKGPNHAVSTACTTGAHAVGDAARFIAHGDAHAMVAGGSEASICPLAIAGFARARALSTSWNSEPRLSSRPFHPEREGFVMGEGAAVMVLE-----E------HGRAVARGA-R-IYAEVLGYGLSGDASHITAPTADGDG-AFRCMSTALRDA--------GV--NP-EEVSYVNAHATSTPLGDAAENAAIKRLFGK-----------------------H--------------------------------A--YS--MAVSST-----------------KGATGHLLGAAGALEAAFTALACYHAILPPTL-NL-DRTD-P-EF--D-L----------N--YVP---------C---T-A----QPWR-------TE--G-RRVGLTNSFGFGGTNASLCLSSI-------------- 132 ---------------MF---------SQCSQELLKI-A---NLHLRSLNL---N-PLL-RN-H--G-------------------------------------------RAFS-K-S-L-PAC--RRKVVVTGIGLVSPLGVGTQLVWKRL-LQGDSGIASLD--G-EE-----------Y-ADIPCRVAACVPRGD----E--E-GH-F----KEE----SFVSKSEIRSMSSATVMAIGAAELAMKDSGWS-P-QSEQ-D-H--L----------RAGVAIGMGMVPLEEISDTAA--------------------------LFK-T-KGYNKVSPFFVPKILVNMAAGQISIKYQLKGPNHAVSTACTTGAHAIGDSFRFIALGDADVMLAGGTEACISPLSLAGFARARALSTSFNARPKMACRPFDSQREGFVMGEGAAVLVLE-----E------YGHAVQRGA-R-IYAEILGYGLSGDACHITAPNPEGDG-AFRCMSAAIKDS--------GI--KP-EDVTYVNAHATSTPLGDAAENQAIKKLFKN-----------------------H--------------------------------S--RN--LAVSST-----------------KGATGHLLGAAGAIEAAFTALSCYHAILPPTL-NL-EKTE-P-EF--D-L----------N--YVP---------L---T-A----QEWK-------TG--K-RRIALTNSFGFGGTNATLCLGSV-------------- 133 -------------------------------------------MNTRPAV---L-R----MSF---------------------------------------------------P--TR-LIP--ARRVVVTGIGLVTCLGVGKDKVWNNL-IKGQCGIRKID--N-E------------A---------GFVPED-------------------VL----KPFTSTEKRQLSEGMMYTLVAAEEALTDANWK-P-ETPQ-E-Q--E----------RTGVTVGMGMNGMEEIYRTAD--------------------------RLF-Q-KGYREINPFFMPKILINMAAGHVSLKYGFQGPNHSVSTACTTGLHAVGDAFRFIQRGDADVMVAGGAEESPNPLSVAGFSRMRALCTKFNNHPTEASRPFDKDRNGFVMSEGAGVLILE-----E------MSHAIDRGA-S-IYAEVLGYGLSGDAFHMTAPRTDGRG-AYRCMLAAIKDA--------GI--SP-TCIGYINAHATSTPLGDKAESQAIWRIFEQ-----------------------C--------------------------------H--QK--PLVSST-----------------KGALGHLLGAAGSVEAAITVLTCQSGIVPPTL-NL-HQSD-T-GV--D-L----------D--YVP---------L---L-T----RDWKA-------E----IRTALTNSFGFGGTNGTLCIRSFD-K----------G 134 ------------------------------------------------------------MSF---------------------------------------------------P--TR-LIP--ARRVVVTGIGLVTCLGVGKDKVWNNL-IKGQCGIRKID--N-ED-----------FPPNIPCKIAGFVPED-------------------VL----KPFTSTEKRQLSEGMMYTLVAAEEALTDANWK-P-ETPQ-E-Q--E----------RTGVTVGMGMNGMEEIYRTAD--------------------------RLF-Q-KGYREINPFFMPKILINMAAGHVSLKYGFQGPNHSVSTACTTGLHAVGDAFRFIQRGDADVMVAGGAEESPNPLSVAGFSRMRALCTKFNNHPTEASRPFDKDRNGFVMSEGAGVLILE-----E------MSHAIDRGA-S-IYAEVLGYGLSGDAFHMTAPRTDGRG-AYRCMLAAIKDA--------GI--SP-TCIGYINAHATSTPLGDKAESQAIWRIFEQ-----------------------C--------------------------------H--QK--PLVSST-----------------KGALGHLLGAAGSVEAAITVLTCQSGIVPPTL-NL-HQSD-T-GV--D-L----------D--YVP---------L---L-T----RDWKA-------E----IRTALTNSFGFGGTNGTLCIRSFD-K----------G 135 -------------------------------------------MNTRPAV---L-R----MSF---------------------------------------------------P--TR-LIP--ARRVVVTGIGLVTCLGVGKDKVWNNL-IKGQCGIRKID--N-ED-----------FPPNIPCKIAGFVPED-------------------VL----KPFTSTEKRQLSEGMMYTLVAAEEALTDANWK-P-ETPQ-E-Q--E----------RTGVTVGMGMNGMEEIYRTAD--------------------------RLF-Q-KGYREINPFFMPKILINMAAGHVSLKYGFQGPNHSVSTACTTGLHAVGDAFRFIQRGDADVMVAGGAEESPNPLSVAGFSRMRALCTKFNNHPTEASRPFDKDRNGFVMSEGAGVLILE-----E------MSHAIDRGA-S-IYAEVLGYGLSGDAFHMTAPRTDGRG-AYRCMLAAIKDA--------GI--SP-TCIGYINAHATSTPLGDKAESQAIWRIFEQ-----------------------C--------------------------------H--QK--PLVSST-----------------KGALGHLLGAAGSVEAAITVLTCQSGIVPPTL-NL-HQSD-T-GV--D-L----------D--YVP---------L---L-T----RDWKA-------E----IRTALTNSFGFGGTNGTLCIRSFD-K----------G 136 ---------------MI---------SQCLQDFLKI-V---NFRPRSSKL---H-QCL-RS-S--K-------------------------------------------NGFSTK-S-L-SKH--QRRVVVTGIGLVSPLGVGTQFVWNRL-LQGESGIISLD--G-EE-----------Y-TSVPCRVAACVPRGN----G--K-GQ-F----SEE----NFVSKSESKSMSSATIMALGAAELAIKDSGWH-P-QSEM-D-H--L----------TAGVAIGMGMVPLEDISNTGL--------------------------LFK-T-KGYNKVSPFFIPKILINMAAGQISIRYQLKGPNHAVSTACTTGAHAVGDSFRFIGYGDADVMLAGGTEASISPLSIAAFARARALSSNFNSSPKLACRPFHSQREGFVMGEGAAVLVLE-----E------YEHAIQREA-R-IYAEILGYGLSGDACHITAPNPDGDG-AFRCMSAAIKDS--------GI--CP-EDITYVNAHATSTPLGDAAENQAIKRLFKE-----------------------H--------------------------------S--YT--LAVSST-----------------KGATGHLLGAAGAIEAAFTALSCYHGILPPTL-NL-DKTE-P-EF--D-L----------N--YVP---------L---T-A----QEWQ-------SE--K-RRIALTNSFGFGGSNATLCFAHV-------------- 137 ------------------------------------------------------------------------------------------------------------------------MTV--ARRVVVTGVGMVCPLGLGVPYVWNRL-VAGDTATAFVA--D-EW-----------A-KPIPCKVAARIPHGT----A--P-HE-L----NIK----GEFSTSELRSLSPATIVSLIAAKEAITDAAWT-P-EDEK-E-R--Q----------ATGVAIGMGIVDLEDILATG---------------------KA-----LE-E-K-YSKVNPFFIPRILTNMAAGQISIKYGFQGPNHSVSTACATGTHSIGDCFRMIKYGDADVMVSGGSEAKVNAIGMAGFSRLRALSVKYNDNPSVASRPFDRDRDGFVMGEGSGIVVLE-----E------LEHARARDA-K-IYAEVLGFGMSGDAHHITSPREDGNG-GERAMKMCMKEA--------SV--GP-ADVGYVNAHATSTPLGDEIELGAIGRVFG-----D------------------N--------------------------------E------VQVSST-----------------KGAVGHLLGAAGAVESIFTILAVHAGFLPPTA-NL-ENPI-Q-VPN-K-V-------N-----IVA---------K---V-G----QPWIDR----H----K-RRIALNNSFGFGGTNACLCFGSYE------------- 138 ---------------ML---------SNCLQNFLKM-T---NSPLIHTRL---C-QRL-IS-E--R-------------------------------------------RFSGTA-P-S-SSL--RRRVVITGIGLVTPLGVGTQLVWDRL-IQGKSGIVPLV--G-EE-----------Y-KTIPCSVAAYVPRGC----D--E-GQ-F----NEQ----NFVTKSDVKAMSSPTIMAIGAAELALKDSGWH-P-QSEA-D-Q--L----------ATGVAIGMGMVPLEVISETAL--------------------------MFQ-T-KGYNKVSPFFVPKILVNMAAGQVSIRHKLRGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALST--NSDPKLACRPFHPERDGFVMGEGAAVLVLE-----E------REHAVQRGA-R-IYAEILGYGLSGDAGHITAPDPGGEG-AFRCMAAAVKDA--------GV--RP-EEVSYINAHATSTPLGDAAENKAIKRLFKD-----------------------H--------------------------------A--QA--LAVSST-----------------KGATGHLLGAAGAAEAAFTALACYHRKLPPTL-NL-DCTE-P-QF--D-L----------N--YVP---------L---K-A----QEWK-------TE--K-RCIGLTNSFGFGGTNATLCIAGM-------------- 139 ---------------ML---------SNCLQSFLKI-T---SPH-LYSGL---C-QQS-IGNK--R-------------------------------------------RFFGTV-P-T-SRI--RRRVVITGIGLVTPLGVGTQLVWDRL-IRGESGIVSLV--G-EE-----------Y-KSIPCSVAALVPRGC----A--D-GQ-F----NEQ----NFVSRSDIKSMSSPTIMAIGAAELAMKDSDWH-P-QSEA-D-R--V----------ATGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYSKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDSFRFIAHGDADVMVAGGADSCISPLSLAGFSRARALST--NSDPKLACRPFHPKRDGFVMGEGAAVMVLE-----E------HDHAVQRGA-R-IYAEVLGYGLSGDAGHITAPDPEGEG-ALRCMAAAVKDA--------SV--QP-EEISYVNAHATSTPLGDAAENKAIKHLFKD-----------------------H--------------------------------T--RA--LAVSST-----------------KGATGHLLGAAGAVEAAFTALACYYQKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---K-A----QEWK-------IE--K-RRIGLTNSFGFGGTNATLCIAAM-------------- 140 --------M------SA---------LPPSCWTKLQ-LRPQ---KVRALL---L-KSA-CVCP--N-------------------------------------------QHYRRC-SSG-Q-Q--RRRVVITGIGLVCPLGTGTALPWDHL-VKAHSGIVALD--S-EE-----------Y-KSVPCKVAALVTRGT----E--E-GQ-F----NVE----RFASRGEINSMSPATVMALGAAQLALEDSGWS-P-KSPE-E-Q--L----------STGVAVGMGMVSLEEIARTSA--------------------------AFQ-E-KGYSKVSPFFVPRILVNMAAGHISIKHRLKGPNHAVSTACTTGAHAVGDAARFILHGDAVAMVAGGTESCVGPLSMAGFARARALATKWNDXPKLASRPFHPEREGFVMGEGAAVLLLE-----E------LEHAVKRGA-R-VYAEVLGYGLSGDASHITAPTADGDG-AFRCMSAALRDA--------GV--ST-ADVTYVNAHATSTPLGDAAENAAIKRLFQQ-----------------------S--------------------------------T--ES--MAVSST-----------------KGATGHLLGAAGALEAAFTALACYHGVLPPTL-NL-DRTE-P-EF--D-L----------N--YVP---------C---T-A----QPWR-------TR--G-RRVALTNSFGFGGTNASLCLASI-------------- 141 ------------------------------MTKLVR-T---CSFLLLSEI---I-IFI-PSQS--L-------------------------------------------VNNLYL-P-----------------GVVTPLGIGVSNVWSKL-LQGKSGIGLLS--G--------------------------------------------------------------------------------------------------------------------------------EKYE--------------------------GIP-S-KGYRKVSPFFVPRILPNLTAGHIGIRYGFQ----LLLPCTPPGCHAVGDAMRFIRNGDAKVMVAGGAEACICPVAVAGFS-----STKYNDRPQESSRPFDARRDGFVMAEGAAVLILEVWSAKE------WNHAESRGA-N-ILAEILGYG---DASHITAPRGDGFG-AQRCMKAALRDA--------RV--RV-EDVGYVNAHATSTPLGDEIENRAIKSVFGS-----------------------H--------------------------------A--NN--LAVSST-----------------KGATGHLLGAAGALEAIFTVLACQHGQLPPTI-NL-EETD-D-EF--D-L----------N--YVP---------N---K-S----QVWL-------GD--G-RRIGLTNSFGFGGTNASLCIGSV-------------R 142 ----------------------------------------------MTRS---Q-PLS-DSGS--V-------------------------------------------YFSRLL-N----PT--GYRARIEHS--VTNFAG--KKLWEVL-MV-EKALDCSG--T-RE-----------I-RQLPCKVAAVMGGDK---HE--H-GD-F----NEE----AFASKGEINSMSPATVMAVGAAQLALEDCGWF-P-RSPE-E-Q--L----------STGVAVGMGMVSLEEIARTAS--------------------------AFQ-T-RGYSKVSPFFVPRILVNMAAGHISIKHKLKGPSHAVSTACTTGAHAVGDAARFIAHGDAEVMLAGGTEACVSPLSIAGFARARALSTNWNQEPRLASRPFHPDREGFVMGEGAAVLVLE-----E------YGHAKQRGA-R-VYAEVLGYGLSGDASHITAPTADGDG-AFRCMSAALRDA--------GV--SP-SDVTYVNAHATSTPLGDAAENAAIKRLFEQ-----------------------H--------------------------------A--YS--LAVSST-----------------KGASGHLLGAAGALEAAFTALACHHGILPPTL-NL-DRTE-P-EF--D-L----------N--YVP---------C---T-A----QTWS-------SS--G-RRVALTNSFGFGGTNASLCLASV-------------- 143 --------------------------------------------------------------------------------------------------------------------------M--NRRVVITGMGINSCIGNTLEAVKHSL-ENGISGTRHNS--T-YEE------------LNFKSHVSAAA--------------E-Q----DF-----DGIDRKLKRFMGVCAMYAYNSALAAVEHAGLT-P-EQLG-G-N--P----------RYGIAGGSGGNSTASVTEMVK--------------------------LLEEK-GA-RKIGPFFVPRNMSNTITANVGVAFKLQGVAHSITSACATSADAIGYAYNLIQLGKQDLMLAGGGEEDHWSQSLL-FDAMGALCSKYNDAPKTASRPYSADRDGFVIAGGGGFVVLE-----------SLEHAQARGA-N-ILAEVVAYAANSDGADMVAPS--GEG-ATRCILMALEEA--------K--QHGVDKVDYVNTHGTSTPAGDVTELLAMGRAFGE-G---------------------------------------------------------NV--PPLSST-----------------KSMTGHSLGAAGVQEAIYSVLMMQNDFIAPNI-NV-TELD-E-GT--KGY-------D-----IVL-----E---------K----RD----------T--K-LNTVMSNSFGFGGVNACLIFKKWE------------G 144 ----------------------------------------------------------------------------------------------------------------------M-NKC--GRRVVITGLGVVSPLGVGVKNSWNAL-LAGKSGIVKLN--T-PE-----------Y-ETLPCRVAGQIPRGN----D--P-GS-L----NLD----EKFSKSELRSMCPATAYALIAAEEALEDAKWK-P-DEET-H-K--R----------DTGVAVGIGMVDLVDVCSIY---------------------EA-----MK-K-S-YSKVSPYFIPRILPNMAAGQISIKYGFRGPNHSVSTACATGAHAIGDAFRFVKGGETSVMVCGAAEACISPLAIAAFCRLRALSTSKNDRPEEASKPFDKDRDGFVMGEGAAILIIE-----E------LEHALARNA-N-IYAEILGYGLSGDAAHLTAPSEDGVG-AILAMDRACKNA--------QV--DL-NDITYVNAHATSTPIGDAVELKAIETLFG-----A------------------S--------------------------------S--KN--VTVSST-----------------KGAHGHLLGAAGNLEIAFTILAIKNSVIPPTL-NL-YNLD-Y-S-G-P-L-------Q-----FVP---------H---V-K----KNWSSV---------S-KRTALKNAFGFGGTNASLCFTEFV-R----------- 145 ---------------MF---------SQCSQELLKT-A---NLHLWSLNL---N-LLL-RN-H--R-------------------------------------------RAFS-E-S-L-PAR--RRKVVVTGIGLVSPLGVGTQLVWKRL-LQGDSGIASLD--G-EE-----------Y-AGIPCRVAACVPRGD----E--E-GQ-F----KEE----SFVSKSEMKSMSSATVMAIGAAELAMKDSGWS-P-QSEQ-D-H--L----------RAGVAIGMGMVPLEEISDTAS--------------------------LFK-T-KGYNKVSPFFVPKILVNMAAGQISIKYQLKGPNHAVSTACTTGAHAIGDSFRFIALGDADVMLAGGTEACISPLSLAGFARARALSTGFNSSPKMACRPFDSQREGFVMGEGAAVLVLE-----E------YGHAVQRGA-R-IYAEVLGYGLSADACHITAPNPEGDG-AFRCMSAAIKDS--------GI--KP-EDVTYVNAHATSTPLGDAAENQAIKRLFKD-----------------------H--------------------------------S--RN--IAVSST-----------------KGATGHLLGAAGAIEAAFTALSCYHAILPPTL-NL-EKTE-P-EF--D-L----------N--YVP---------L---T-A----QEWK-------TE--K-RRIALTNSFGFGGTNATLCFASV-------------- 146 ---------------MF---------SQCSQELLKT-A---NLHLRSLNL---N-LLL-RN-H--R-------------------------------------------RAFS-E-S-L-PAR--RRKVVVTGIGLVSPLGVGTQLVWKRL-LQGNSGIASLD--G-EE-----------Y-AGIPCRVAACVPRGD----E--E-GQ-F----KEE----SFVSKSEMKSMSSATVMAIGAAELAMKDSGWS-P-QSEQ-D-H--L----------RAGVAIGMGMVPLEEISDTAS--------------------------LFK-T-KGYNKVSPFFVPKILVNMAAGQISIKYQLKGPNHAVSTACTTGAHAIGDSFRFIALGDADVMLAGGTEACISPLSLAGFARARALSTGFNSSPKMACRPFDSQREGFVMGEGAAVLVLE-----E------HGHAVQRGA-R-IYAEVLGYGLSADACHITAPNPEGDG-AFRCMSAAIKDS--------GI--KP-EDVTYVNAHATSTPLGDAAENQAIKRLFKD-----------------------H--------------------------------S--RN--IAVSST-----------------KGATGHLLGAAGAIEAAFTALSCYHAILPPTL-NL-EKTE-P-EF--D-L----------N--YVP---------L---T-A----QEWK-------TE--K-RRIALTNSFGFGGTNATLCFASV-------------- 147 -------------------------------------------MFLRLCG---G-SLS-TVKS--C-------------------------------------------MCLRRY-TRA-AQS--HRRVVITGIGLVSPLGTGSALPWQRL-IGGESGLVALD--P-EE-----------Y-KTVPCKVAARVPRGD----K--H-GD-F----NEE----AFVSRGEINSMSPATVMAVSAAQLALEDCGWF-P-RSPE-E-Q--L----------STGVAVGMGMVSLEEIARTAS--------------------------AFQ-T-RGYSKVSPFFVPRILVNMAAGHISIKHKLKGPNHAVSTACTTGAHAVGDAARFIAHGDAEVMLAGGTEACVSPLSIAGFARARALSTNWNQEPRLASRPFHPNREGFVMGEGAAVLVLE-----E------YRHAEQRGA-R-VYAELLGYGLSGDASHITAPTADGDG-AFR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 148 ------MF--------------------------C-----------P---IKFL-K------RGR------------------------------------------------S-LTTA-VRC--KRRVVITGLGLVCPLGVGVQNAWKNL-LESKSGIIKLS--D-VD-----------Y-DKLPCRVAAVIPKGD----Q--S-HE-L----DIK----SYFSKSELRTMCSATAYALISSEEALSDAKWK-P-EEEN-D-R--R----------DTGVAVGIGMIDLVDVCATY---------------------EA-----LK-K-G-YSKVSPYFVPRILPNMAAGHISIKYGFRGPNHCVSTACATGAHAIGDAFRFIRGGETNVMVCGGAEACISPLAVAAFCRLRALSTSRNDSPYEASRPFDRDRDGFVMGEGSAILVLE-----E------LNHALSRQA-P-IYAEILGYGLSGDAAHITAPSEDGTG-ALLAMDRAVKDA--------GI--ET-SEITYINAHATSTPLGDNIELKAVESLMG-----E------------------H--------------------------------S--KN--VFVSST-----------------KGAHGHLLGAAGNLEAAFTILAIKDAVIPPTL-NL-HNLD-I-E-T-S-L-------N-----FVP---------N---V-K----KNWSAT---------G-RRVALKNAFGFGGINACLCFAEYI-A----------- 149 ------MF--------------------------C-----------P---IKFL-K------RGR------------------------------------------------S-LTTA-VRC--KRRVVITGLGLVCPLGVGVQNAWKNL-LESKSGIIKLS--D-VD-----------Y-DKLPCKVAAVIPKGD----Q--S-HE-L----DIK----SYFSKSELRTMCSATAYALISSEEALSDAKWK-P-EEEN-D-R--R----------DTGVAVGIGMIDLVDVCATY---------------------EA-----LK-K-G-YSKVSPYFVPRILPNMAAGHISIKYGFRGPNHCVSTACATGAHAIGDAFRFIRGGETNVMVCGGAEACISPLAVAAFCRLRALSTSRNDSPYEASRPFDRDRDGFVMGEGSAILVLE-----E------LNHALSRQA-P-IYAEILGYGLSGDAAHITAPSEDGTG-ALLAMDRAVKDA--------GI--ET-SEITYINAHATSTPLGDNIELKAVESLMG-----E------------------H--------------------------------S--KN--VFVSST-----------------KGAHGHLLGAAGNLEAAFTILAIKDAVIPPTL-NL-HNLD-I-E-T-S-L-------N-----FVP---------N---I-K----KNWSAT---------G-RRVALKNAFGFGGINACLCFAEYI-A----------- 150 ---------------------------------------------MS---GRII-N------QIR------------------------------------------------T-I-TQ-SPH--KRRVVVTGLGVVSPLGTGTELVWQNI-LKGQCGIVALP--G-NE-----------Y-SKLPCRIAGLIPSEK----------D-D----VVA----KALSKSNLKSMAPATCLALVATAEALADAKWS-P-TSEH-D-K--E----------ATGVAIGMGMIDLKDVCDTN---------------------DA-----LK-V-G-YNKVSPFFVPRILPNMAAGHISIKYGFRGPNHAVSTACATGAHSVGDAFRFIRNGDADVMVCGGAEACISPLAIAGFSRLRALSTSFNDNPTKASRPFDKKREGFVMGEGAAILVLE-----E------YQHALDRNA-K-IYAEILGYGLSGDASHITAPRDDGSG-AVLSMKRALRDG--------CI--DT-DKITYINAHATSTPVGDGIEATAIKTLFQ-----D------------------H--------------------------------S--SN--ILVSST-----------------KGAHGHLLGAAGNLEAIFTILACHHGVIPPTI-NL-EEPV-D-----D-L-------N-----YVA---------N---E-S----KPWNA----------D-RRIALKNSFGFGGTNATLCIGQM-------------- 151 --------M------SA---------LQLSCWTKLL-PRPQ---SMAAFL---Q-KRG-CTCP--D-------------------------------------------QESRRH-SSG-W-P--RRRVVVTGIGLVCPLGTGTALAWDNL-IKAHSGIVALD--P-EE-----------Y-KTVPCKVAALVPRGT----E--V-GQ-F----NEE----KFASRGEINSMSPATVMALGAAQLALEDSGWC-P-NTPE-E-Q--L----------NTGVAVGMGMVSLDEIARTSA--------------------------AFQ-E-KGYNKVSPFFVPRILVNMAAGHISIKFRLKGPNHAVSTACTTGAHAIGDAARFIAHGDAVAMVTGGTESCVGPLSIAGFARARALATKWNDNPALASRPFHPEREGFVMGEGAAVLLLE-----E------LNHAVRRGA-R-IYAEVLGYGLSGDASHITAPTADGDG-AFRCMSAALRDA--------CI--LP-ADVTYVNAHATSTPLGDAAENAAIKRLFQQ-----------------------S--------------------------------I--DT--LAVSST-----------------KGATGHLLGAAGALEAAFTALACYHGVLPPTL-NL-DRTE-P-QF--D-L----------N--YVP---------C---T-A----QTWQ-------TQ--N-RRVGLTNSFGFGGTNASLCLANV-------------- 152 -----------------------------------------MTLSVLRKT---C-CRV-FLKC--T-------------------------------------------APTKSG-YRH-IHK--IRRVVVTGRGVVSCLGVGADIVWQRL-MKGHCGITSLD--G-KE-----------Y-DGIPCRVAGIIPRGD----K--S-GQ-L----NID----KVIEPSKQRTMSEGSMYVLVAAEEALNDARWK-P-VTEE-D-K--I----------RTGVAIGMGLVGMKEIYQTKE--------------------------MMN-Q-KGYKGVHPHFLPKILVNMAAGNVSVKFGLKGPNHAVSTACTTGLHSIGDACRFIQHGDADVMIAGGTEESPNPLSVAGFSKMRALSTSYNDNPKQASRPFDRKRDGFIMSEGAAVLVLE-----E------LSHALNRGA-T-IYAEILGYGLSGDGHHITAPIEDGNG-AYRCMKSALNDA--------QV--ES-SQIDYVNAHATSTPLGDMAESKAIMKCLGG-----------------------N-----------------------------------TN--LRVSST-----------------KGATGHLLGAAGSIEALFTVMSCYSGKIPATL-NL-HEPD-T-GV--V-L----------N--YIA---------N---D-S----VDWIS------KS--S-KRIALTNSFGFGGSNGCLCISSFI------------Q 153 -----------------------------------------MPLSVSRKT---F-CRE-FLKC--T-------------------------------------------APNKSA-YRQ-RHG--IRRVVVTGRGVVSCLGVGADIVWQRL-LKGHCGITFLD--G-KE-----------Y-DGIPCRVAGLIQRGD----K--S-GQ-L----NID----KAIEPSKQRTMSEGSMYVLVAAEEALNDARWK-P-VTEE-D-K--I----------RTGVAIGMGLVGMKEIYQTKD--------------------------MMN-Q-KGYKGVNPFFLPKILVNMAAGNVSVKFGLKGPNHAVSTACTTGLHSIGDACRFIQHGNADVMIAGGTEESPNPLSVAGFSKMRALSTSYNDNPKQASRPFDRKRDGFIMSEGAAVLVLE-----E------LSHALNRGA-T-IYAEILGYGLSGDGHHITAPSEDGSG-AYRCMKTALNDA--------QV--ES-SQIEYVNAHATSTPLGDMAESKAIMQCLGG-----------------------N-----------------------------------TD--LRVSST-----------------KGATGHLLGAAGSIEAFFTVMSCYSGMIPGTL-NL-YEPD-T-GV--V-L----------N--YIA---------N---D-S----VDWIS------KS--S-KRIALTNSFGFGGTNGCLCISSFI------------Q 154 -------------------------------------M---RVLGKCT---VLV-R------QTR---------------------------------------------S-----LST-PSG--RRRVVVTGSGAVTPLGNNGPDSWRRI-LAGESAISRLS----AE-----------F-KGLPCQVAAQIPRE-----------N-L----QLD----QHLTKSDIKLMSPATQLAVLAAEEALSTGKLC-P-KQLS-E-EELE----------RFGVCVGMGMFDLAEVYGAW---------------------NQ-----LQ-R-G-YNRVSPFFVPRLLPSMACGHISMRHGLRGPNHSVSTACATGAHALGDAMRFIRSGDADLMLAGSGEACIDPLSIAGFCRLRALSTAFNDNPAVASRPFDKSRDGFVMGEGAAVLLLE-----E------LEHARARGA-P-ILAEILGYGLSGDAYHITSPSDDGAG-ATLAMKRAIQDA--------GI--AP-EDVTYVNAHATSTPTGDRIESHAIGRVFG-----A------------------H--------------------------------T--PQ--VRVSST-----------------KGAHGHLLGSSGNLEALFVVLACANNKLPPSI-NI-EHLD-V-D-V-N-V---------------V---------T---K-A----TDWS-A---DQ----K-RRVALKNSFGFGGTNASLCIASYI------------- 155 --------MCLIIATMF---------SQCSRDLLKI-A---NLHLWSLSL---N-LHL-QN-H--R-------------------------------------------RAFS-K-S-L-PAC--RRKVVVTGIGLVSPLGVGTQFVWKHL-LEGGSGIISLD--G-EE-----------Y-AGIPCRVAACVPRGN----K--E-GE-F----SEE----SFVSKSEIKSMSSATVMAISAAELAMKDSGWS-P-QSEQ-D-R--L----------TAGVAIGMGMVPLEEISDTAA--------------------------VFK-T-KGYSKVSPFFVPKILVNMAAGHISIRYQLKGPNHAVSTACTTGAHAVGDSFRFIAAGDADVMLAGGTEACISPLSLAGFARARALSTSFNSSPKTACRPFDSQREGFVMGEGAAVLVLE-----E------HGHAVQRGA-R-IYAEVLGYGLSGDACHITAPNPEGDG-AFRCMSAAIKDS--------GI--KP-EDVTYVNAHATSTPLGDAAENQAIKRLFKD-----------------------H--------------------------------S--RN--IAVSST-----------------KGATGHLLGAAGAIEAAFTALSCYHGILPPTL-NL-QKTE-A-EF--D-L----------N--YVP---------L---T-A----QEWK-------TD--K-RRIALTNSFGFGGTNATLCFASV-------------- 156 ---------------------------------------------------------------------------------------------------------------------------------------MLTPLGNDVTSSWQGL-QQAKSGISLI--EH-FDT------------SAYTTKFAGLVKD--------------F----DVE----PYFPAKDAKKMDLFIQYGVAAAMQAFRDS-GL-EINEV--NA---H----------RIGAAIGSGIGGLGLIEENHT--------------------------KLM-N-SGPKRLSPFFVPSTIINMIAGQLSIMLGLKGPNISIVTACTTGVHNIGQAARMIAYGDADAMVAGGAEKASTELGMGGFGAARALSTR-NDAPQQASRPWDKDRDGFVLGDGAGVMVLE-----E------YEHAKARGA-K-IYAELVGFGMSGDAYHMTSPPENGDG-AARAMKNALNDA--------QV--NP-EQVQYINAHGTSTPAGDIAETMAIKTVFAN----N---------------------------------------------------L--DK--LMVSSS-----------------KSMIGHLLGAAGSVESIITVLSLQDQLVTPT-INL-DNPS--EGC--D-LD------------YVP---------H---Q-A----RQAK-------------LEYALCNSFGFGGTNGSILFKKV-------------- 157 -----------------------------------------------------------------------------------------------------------------------------MKRAVITGLGIVSSIGNNQAEVLASL-KAGKSGISRAE--E-FAE------------LGLRSQVWGNI--------------K-L----DPS----ELIDRKAMRFMGDAAAYAYLAMQEAMQDAGLS-D-EQIS---H--P----------RVGLVVGSGGASSKTQVEAAD--------------------------ILREK-GV-KRVGPYAVPKTMSSTCSACLATPFKIKGVNYSISSACATSAHCIGHAMELIQLGKQDIVFAGGGEEVHWTLAME-FDAMGALSSRYNDTPELASRTYDANRDGFVISGGGGIVVVE-----------ELEHALARGA-T-IYAEIVGYGATSDGYDMVAPS--GEG-AVRCMQMAMQGV--------D--A----PIDYLNTHGTSTPVGDVKELGAIQEVFA--G---------------------------------------------------------KT--PAISAT-----------------KAMTGHALGAAGVHEAIYSLLMLKHNFIAPSI-NI-GELD-E-AA--KGL-------D-----IVT-----Q---------T----RD----------A--V-LNTVMSNSFGFGGTNATLVMQRYK------------G 158 --------------------------------------------------------------------------------------------------------------------------M--SRRVVVTGVGLITPLAADVDNTWLRL-IKSESGIKAINADR-FDS------------SDLACKVAGQVPVQS----DNIE-NY-F----NPV----GYISEKDLKRTDRFIHYGIAAAIQAVNDSLIL-ESQNI--NR---E----------RIGVTIGSGIGGLPSIQENVI--------------------------TMQ-E-KGPRRVSPFFVPASLINLISGHISIKYEFTGPNDSAVTACATGAHAIINSARTIKLGEADIMIAGGAESALCRVGIAGFASMKALSTKFNDKPEEASRPWDAERDGFVMGEGAGILVLE-----E------YEHAKKRGT-K-IHAELVGYGLTGDAHHITAPHPEGRG-AFKAMQLALKSA--------QI--NP-DQVGYINAHGTSTPLGDKIEVIAMKQLFGD----Y---------------------------------------------------V--YK--IPVSST-----------------KSSIGHLLGAAGSVEAIFSILALNNGIIPPT-LNL-HKPS--EGC--D-LN------------FVP---------F---K-A----QEHK-------------IQYALSNSFGFGGTNASLIFGQV-------------- 159 -------------------------------------------------------------------------------------------------------------------------MS--KRRVVVTGMGMLTGLGASVDKTWSGI-VAGRSGIAPI--TH-FDC------------SAFSTRFAGLVPD--------------F----VVD----DYMPAKEARRFDEFIQYGLAAGTQALADS-GI-TVSEA--NA---A----------RIGVAVGSGIGGLTTIEGGHA--------------------------GML-D-GGPRKISPFFVPGSIINMAAGMLAIRHGLKGPNLAIATACTTASHCIGLAARLIAYGDADVMLAGGAEKASCPLGLGGFAAARALSTR-NDAPQQASRPFDRDRDGFVMGDGAGVVVLE-----E------YEHAKARGA-N-ILAELIGFGMSDDAYHITSPSEGGEG-AAAAMRNALRDA--------GL--NP-EQVDYINAHGTSTPAGDVAETRAIESVFGD----H---------------------------------------------------A--RR--LAVSST-----------------KSMTGHLLGAAGGVEAIFSVLALRDQVLPPT-INL-DNPD--PAC--T-LD------------YVP---------H---T-A----RDAK-------------LDVVLSNSFGFGGTNGSLIFRRV-------------- 160 ---------------MS---------DIQ-ERVKKI-I---IEQL---GV---KEEEVKH--E--ASFVDDLGADSLDTVELVMALEEEFDTEIPDEEAEKITTVQAAIDYVTAH-AEQ-PVA--KRRVVVTGLGMLTPLGNDVESTWQGL-LNGKSGIQTI--TH-FDT------------SSFGTKFAGLLND--------------F----DAS----AYMSPKDAKKMDLFIQYGIAAGVQALQDS-GL-EITEE--NA---T----------RVGVAVGSGIGGLTLIEENHI--------------------------KLL-N-SGPRKLSPFYVPSTIINMISGHLSIMHGLRGPNISIVTACTTGLHNIGHAARMIAYGDADAMVAGGAEKASTPIGMGGFNAARALSTR-NDDPQAASRPWDKDRDGFVLADGAGVIVLE-----E------YEHAKARGA-K-IYAELVGFGMSGDAYHMTSPPEDGAG-AALAMENALNDA--------QV--NA-DQVGYINAHGTSTNAGDKAETSAVKTIFGD----A---------------------------------------------------A--KD--VMVSSS-----------------KSMMGHLLGAAGSVESIITILSLVDQKVSPT-INL-DNPD--EGC--D-LD------------YVP---------H---T-A----RDAK-------------LDYALCNSFGFGGTNGSLLFKKV-------------- 161 ----------------------------------------------------------------------------------------------------------------------------------ITGLGLAAPVGAGWRTVWAQV-LAGRPNFGRLS--EADGY------------SGLPCRVAGLIPEAE----L--S----G----WPS----WQFDKRNRAEMSRASALALAAAREAAQGADLA-GMRRRS-P-D--S----------LIGVAIGCGMDGLETAVDAGV--------------------------GLRSG-RGYAEVGPHFLTKLLNNMPAGRVAIEFGATGPCLSPNSACASGADAIGAAFRLVRDGIVDAALCGGTEACIGPLAVAAFSRVRALTTRFNDNPLAASRPFDADRCGFVMSEGAGVLVLE-----A------LDSALARGA-PAPIAEVLGYGAACDAHHLTAPKLGGDSGARRCMLAALREAGNHSAAWQRP--LA-LQVGHVNAHATSTPIGDSAEWLAIESLLSGADASV------------------I--------------------------------Q--PG--CLVASC-----------------KGALGHLIGAAGAVEAALTALSCQTGRVPPTA-NL-ARPD-L-PTASESL----------R--LVP---------D---GPP----ADWPTN----PAD--G-RRVALSNSFGFGGVNASLCIASYLP------------ 162 ---------------------------------------------------------------------------------------------------------------------------------------LAAPVGAGWRTVWAQV-LAGRPNFGRLS--EADGY------------SGLPCRVAGLIPEAE----L--S----G----WPS----WQFDKRNRAEMSRASALALAAAREAAQGADLA-GMRRRS-P-D--S----------LIGVAIGCGMDGLETAVDAGV--------------------------GLRSG-RGYAEVGPHFLTKLLNNMPAGRVAIEFGATGPCLAPNSACASGADAIGAAFRLVRDGIVDAALCGGTEACVGPLAVAAFSRVRALATRFNDNPLAASRPFDADRCGFVMSEGAGVLVLE-----A------LDSALARGA-PAPIAEVLGYGAACDAHHLTAPKLGGDSGARRCMLAALREAGNHSAAWQRP--LA-LQVGHVNAHATSTPIGDSAEWLAIESLLSGVDASV------------------I--------------------------------Q--PG--CLVASC-----------------KGALGHLIGAAGAVEAALTALSCQTGRVPPTA-NL-ARPD-L-PTASESL----------R--LVP---------D---GPP----ADWPTN----PAD--G-RRVALSNSFGFGGVNASLCIASYLP------------ 163 ----------------------------------------------------------------------------------------------------------------------------------ITGLGLAAPVGAGWRTVWAQV-LAGRPNFGRLS--EADGY------------SGLPCRVAGLIPEPE----L--S----G----WPS----WQFDKRNRAEMSRASALALAAAREAAQGADLA-GMRRRS-P-D--S----------LIGVAIGCGMDGLETAVDAGV--------------------------GLRSG-RGYAEVGPHFLTKLLNNMPAGRVAIEFGATGPCLAPNSACASGADAIGAAFRLVRDGIVDAALCGGTEACIGPLAVAAFSRVRALATRFNDNPLAASRPFDADRCGFVMSEGAGVLVLE-----A------LDSALARGA-PAPIAEVLGYGAACDAHHLTAPKLGGDSGARRCMLAALREAGNHSAAWQRP--LA-LQVGHVNAHATSTPIGDSAEWLAIESLLSGVDASV------------------I--------------------------------Q--PG--CLVASC-----------------KGALGHLIGAAGAVEAALTALSCQTGRVPPTA-NL-ARPD-L-PTASESL----------R--LVP---------D---GPP----ADWPTN----PAD--G-RRVALSNSFGFGGVNASLCIASYLP------------ 164 ---------------ML---------SDGLQSFLRI-T---KCHLIRAGS---C-QRL-IK-E--R-------------------------------------------RFLATA-P-A-PGL--RRRVVVTGIGLVTPLGVGTQLVWDRL-VRGESGIVSLI--G-EE-----------Y-QSIPCSVAAYVPRGC----D--E-GQ-F----NEQ----NFVPKSDTKAMSPPTVMAIAAAELALKDAGWH-P-QSEA-D-Q--A----------ATGVAIGMGMVPLEVISETAL--------------------------TFQ-T-KGYSKVSPFFVPKILVNMAAGQVSIRHKLKGPNHAVSTACTTGAHAVGDSFRFVAHGDADVMVAGGADACISPLSLAGFARARALST--NADPKSACRPFHPQRDGFVMGEGAAVLVLE-----E------HGHALRRGA-R-VYAEIVGYGLSGDAGHITAPDPGGEG-AFRCMAAAVKDA--------GI--QP-EEVTYINAHATSTPLGDAAENKAIKQLFKD-----------------------H--------------------------------A--RA--LAVSST-----------------KGATGHLLGAAGAAEAAFTALACHHRKLPPTL-NL-DCTE-P-QF--D-L----------N--YVP---------L---K-A----QEWK-------AE--K-RRIALTNSFGFGGTNATLCIAGM-------------- 165 -------------------------------------M---RLLRSSK---FFV-P------QAR---------------------------------------------N-----SST-QAG--RRRVVITGSGAVTPLGNNAQDSWRRV-LAGESAISKLG----PE-----------F-KGLPCQVAAQISRE-----------N-L----QLE----THLSKTDIKLMSPATQLAVLAAEEALASGNLK-P-KELS-E-EQRE----------RFGVCVGMGMFDLAEFTASG-----------------------------T---S-YSVAT----IELLPSMACGHISMRHGLRGPNHSVSTACATGAHALGDAMRFIRSGDADVMLAGSGEACIDPLSIAGFCRLRALSTAFNDNPAVASRPFDKARDGFVMGEGAAVLLLE-----E------LEHARARGA-P-ILAELLGYGLSGDAHHITSPSEDGAG-ATLAMQRALKDA--------GV--SP-KEISYVNAHATSTPTGDRIESYAISRVFG-----E------------------H--------------------------------T--PQ--VQVSST-----------------KGAHGHLLGSSGNLEALFVVHACAENTLPPSI-NI-EQLD-V-N-V-N-V---------------V---------T---K-A----CEWS-Q---GQ----G-RRVALKNSFGFGGTNASLCIASYSEE----------- 166 --------------------------------GLVT-P---LGSGTEYVW---R-RLI-NGAC--G-------------------------------------------LACISD-KG---SQQNMENMAWHATGFV-PAGTG-EGEFDQT-SWHKS--RSTS--D-EA-----------Y-FAVAAAQEAFDSCG-----------W-----------------------------------------TPAT-Q-EEKE-----------------KTGVSIGTGIGDTKGLPEMGA--------------------------ILK-N-QGYKKVGPFFVTRSLLSMSSGIVSMYFNLQGPNHAVATACAAGAHAIGDAYRMIAHGDANVMLAGGTESAITPLCMASLCKARALTTKYNDSPHEASRPFDRDRSGFVIAEGAGILVLE-----E------HQHAVSRGA-H-IYAEMLGYGLSGDAHHITAPSQDGRG-AYLAMSNALRDA--------GL--SP-SDIHYINAHATSTPLGDAVENRAIVRLFAN-----------------------DNR------------------------------Q--HE--LKISST-----------------KGAVGHLLGAAGAVEAIFTILALKKGLCPPTL-NL-QNFD-P-EE--D-F-------QRFN--YVA---------N---N-A----QPLTTD--P--ST--T-RLVALTNSFGFGGTNACLCIGQYV------------E 167 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGNAAAYSYLAMDQAIKDAGLS-E-DQVS---N--V----------RTGLIAGSGGASSADIVESAD--------------------------ILRDK-GV-RRVGPYRVTRTMGSTVSACLATPFKIKGINYSITSACATSAHCIGNAMEQIQMGKQDVVFAGGGEELHWSLTVM-FDAMGALSSKYNETPEKASRAYDANRDGFVIAGGAGMLVLE-----------DLEHAKARGA-K-IYAEVVGYGATSDGYDMVAPS--GEG-AMRCMQQAMSTV--------D--G----KIDYINSHGTSTPAGDIQELKAMKQTFG--T---------------------------------------------------------EM--PPVSST-----------------KSLTGHSLGATGVQEAIYSLLMMENDFICASA-NI-EELD-P-EA--DGM-------P-----VVT-----E---------R----RDN---------V--K-LDRVMSNSFGFGGTNSTLVFQRYE------------G 168 ----------------------------------------------------------------------------------------------------------------------------------------QTRFACEIKNFKVTD-FLDR----------------------------------------------------------------------KEARKMDKFTQYAMVATDEAIADSGLH-SAGFD--P----D----------RVGVIWGSGIGGLETFQTEVT--------------------------NFNNG-DGTPRFNPFFIPKMIADIAPGHISIKNGFRGPNFATVSACASSSNAIIDSLNYIRLGHADVIVTGGSEAAVTEAGIGGFNAMHALST-RNDSPETASRPFDKDREGFVLGEGAGALVLE-----E------YEHAIARGA-TI-YAEVIGGGMSSDAHHITAPHPEGL-GAKNVMLNCLRDAGIQP-----------EEVDAINMHGTSTPLGDIAESKAILDVFGDHAY-----------------------------------------------------T------ININST-----------------KSMTGHLLGAAGAIEAIASILAIKHGTVPPTI-NHFTDDD-Q-IDSK--L----------N--FTF---------N---TA-----QER-------A------VKIAISNTFGFGGHNACVALKKI-D------------ 169 -------------------------------------M---RVLGKCT---ILV-R------QTR---------------------------------------------S-----LST-QSG--RRRVVVTGSGAVTPLGNNGPDSWRLI-LAGESAISRLS----AE-----------F-KGLPCQVAAQIPRE-----------K-L----HLD----QHLTKSDIKLMSPATQFAVLAAEEALATGKLC-P-KQLS-E-EELE----------RFGVCVGMGMFDLAEVYGAW---------------------NQ-----LQ-R-G-YNRVSPFFVPRLLPSMACGHISMRHGLRGPNHSVSTACATGAHALGDAMRFIRSGDADVMLAGSGEACIDPLSIAGFCRLRALSTAFNDNPSVASRPFDKSRDGFVMGEGAAVLLLE-----E------LEHARARGA-P-ILAEILGYGLSGDAYHITSPSDDGAG-ATLAMKRAIQDA--------GI--AP-EDVTYVNAHATSTPTGDRIESHAIGRVFG-----A------------------H--------------------------------T--PQ--VRVSST-----------------KGAHGHLLGSSGNLEALFVVLACADNKLPPSI-NI-EHLD-V-D-V-N-V---------------V---------T---K-A----TEWS-A---DQ----K-RRVALKNSFGFGGTNASLCIASYI-E----------- 170 ------NA-----------------------------------IRQP---IWRQ-LYH-PVCN-L---------------------------------------------PRRA-SSKS-RDK--IRRVVVTGLGLVTPLGADVKTSWSRL-IQSQSGIVRLG----K-E----------F-DGIPSRIAGRVPTDAS--QN--P-VP-F----DVH----KFVSKSELRSIPMATVYAMAATKEALDDAQWH-P-NADT-E-C--R----------STGVAIGMAMSDLDYIIDSG---------------------TA-----FR-D-KGYSKLSPFFVPRILTNMASGHISIQHKLRGPNHSVATACTTGLHAIGDAFSFIQRGYADVMVCGGTEASVSPISVAAFARMRALST--AEDPAKASRPFDKDREGFVVSEGSAILVLE-----E------LEHAVARGA-N-IHAEILGYGLSGDGFHITASASDGKG-AYASMQSALKNA--------GI--DV-DEVGYVNAHATSTPIGDAAEAVAIHRLFD-----G------------------S--------------------------------S--RS--VAVSAT-----------------KGSTGHLLG----------------------------------------------------------------------------------------------------------------------------------- 171 ------MQ-----------------------------------FRQP---IWRQ-LYH-PVCN-L---------------------------------------------PRRA-SSKS-RDK--TRRVVVTGLGLVTPLGADVKTSWSRL-IQSQSGIVRLG----K-E----------F-DGIPSRIAGRVPTDAS--QN--P-VP-F----DVH----KFVSKSELRSIPMATVYAMAATKEALDDAQWH-P-NADT-E-C--R----------STGVAIGMAMSDLDYIIDCG---------------------TA-----FR-D-KGYSKLSPFFVPRILTNMASGHISIQHKLRGPNHSVATACTTGLHAIGDAFSFIQRGYADVMVCGGTEASVSPISVAAFARMRALST--AEDPAKASRPFDKYREGFVVSEGSAILVLE-----E------LEHAVARGA-N-IHAEILGYGLSGDGFHITASASDGKG-AYASMQSALKNA--------GI--DV-DEVGYVNAHATSTPIGDAAEAVAIHRLFG-----G------------------S--------------------------------S--RS--VAVSAT-----------------KGSTGHLLGAAGAMESVFVVLAVRDAIIPPTL-NL-EHPD-V-G-V-N-L-------N-----FVA---------L---K-S----RAWEPR---MP----L-GGLL--------------------------------- 172 ----------------------------------------------MR---FFL-S------QIR---------------------------------------------K-----VST-QAA--RRRVVVTGSGAITPLGNNVGESWQRL-LAGESAISRLG----EE-----------F-KGLPCQVAAQIPKE-----------R-L----QLD----KHLSKSDIKLMSPATQLAVMAADEALAMAQLK-P-SELS-P-EQRE----------RFGVCVGMGMFDLSEVYGAW---------------------QQ-----LQ-R-G-YNRVSPYFVPRLLPNMACGHISMRHGLRGPNHSVSTACATGAHAIGDALRFIRNGDADIMLAGSGEACIDPLSIAGFCRLRALSTSFNDNPAIASRPFDKARDGFVMGEGAAVLVLE-----E------LEHAQARGA-P-ILAELLGYGLSGDAHHITSPSEDGAG-ATLAMLRALKDA--------DV--AA-SDVSYVNAHATSTPTGDRIEAHAIKRVFG-----A------------------H--------------------------------A--AN--VFVSST-----------------KGAHGHLLGSSGNLEALFVVHACADNQLPPSI-NV-TDLD-V-D-I-N-V---------------V---------Q---K-A----CQWSES---KH----E-RRVALKNSFGFGGTNASLCISSFTIN-S-------NC 173 ----------------------------------------------------------------------------------------------------------------MDM-SSS-NPH--RKRVVITGIGMVSPLAVGAQQTWDYL-VSGKSGIGPI--TH-FDR------------TLYPAQVAGEVPEGA----T-SE-GK-L----NLD----DWIQPKDQKKMDRFIHLGLVAAIQAVEDSGWK-PTDEE--DL---C----------STGVLIGSGIGGLQNIYN-AS--------------------------LLI-N-SGKKRVSPFFIPSALINLIAGHLSIKYGFKGPNHAVVTACATGLHAIGDASRLIQHGDADVMVAGGAEAAVCSIGVAGFNASRALSTHFNDTPTKASRPWDKDRDGFVMGEGAGMVVLE-----E------YEHAKRRGA-K-IYGELVGYGLSGDAYHITAPSEGHDG-AFRAMKATLKDA--------RM--NP-NEIDYVNAHGTST-MADDLELSAVERIFGD----Y---------------------------------------------------G--RN--LAMSST-----------------KSAIGHLLGAAGAVETIFCLQAMNNNVAPPT-LNL-DNPS--TET--L-ID------------RVA---------H---T-A----QDRK-------------IDAALSNSFGFGGTNASLLLKKV-------------- 174 ------------------------------------------------------------------------------------------------------------------------MYG--PRRVVVTGIGLVTCLGTGTDLVWKNV-IQGKCGIVALT--G-EE-----------F-SKVPSRVAGLVKHGY----D--P-GG-F----NLS----KINLKIDLKSASTSSLYALVAANEAIQQAKLD-L-SDEY-T-Q--R----------RTGVAIGMSMIGLDEIVATSE--------------------------RFK---IGYNKVSPHFVPKILTNMPAGLISIQYKIKGLNHSVATACTTGLHSLGDAFRFIRNGDVDAIVCGSTESCVGPLALAGFCRMRALSTNFNSDPLTASRPFDDLRDGFVMSEGACIMVME-----S------LGSARRRGI-K-PICEVLGYGLSSDANHITAPCPHGEG-AEMCMLAALRDA--------NI--QP-GAIGYVNAHATSTSLGDAAEAEAIYRIFAG-----------------------ADSKAHNAICNNVIDTIPYENYSDIKYQQQMTAI--KG--PAVSST-----------------KGALGHMLGAAGSTEVALAALACNKGVIPPSI-NL-YSTS-SIDV--A-L----------D--FVR---------N---K-C----RDWSRSGEI--RS--K-RRVALSNSFGFGGTNASLCVAEFL------------E 175 ---------------MF---------SQCSRDLLKI-T---NRHLRSLNL---N-LRL-QN-H--R-------------------------------------------RAFS-K-S-V-PVC--QRKVVVTGIGLVSPLGVGAQFVWKRL-LQGASGIASLD--R-EE-----------Y-AGVPCKVAACVPRGN----E--E-GQ-F----SEE----SFVSKAEMKSMSSATVMAIGAAELAMKDSGWS-P-QSEQ-D-R--L----------SAGVAIGMGMVPLEEISDTAA--------------------------LFK-T-KGYNKVSPFFVPKILVNMAAGQISIKYQLKGPNHAVSTACTTGAHAVGDSFRFIAAGDADVMLAGGTEACISPLSLAGFARARALSTSFNSDPKMACRPFDSQREGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEVLGYGLSGDACHITAPNPEGDG-AFRCMSAAIKDA--------GI--KP-EDITYVNAHATSTPLGDAAENQAIKRLFKD-----------------------H--------------------------------S--RN--IAVSST-----------------KGATGHLLGAAGAIEAAFTALSCYHGILPPTL-NL-QKAE-A-DF--D-L----------N--YVP---------L---T-A----QEWN-------TE--K-RRIALTNSFGFGGTNATLCFASV-------------- 176 ---------------------------------------------------------------------------------------------------------------------------------------MLSPVGNTVESTWNAI-LAGKSGIGPI--DH-FDT------------SAFATRFAGLVKD--------------F----NCD----EYISRKDARKIDPFIQYGIAAGVQAMRDS-GF-EVTEE--NA---P----------RIGTAIGSGIGGLGLIEEAHS--------------------------ALI-H-GGPRKVSPFFVPSTIINMTAGQLSIMFGLRGPSISIATACTSGVHNIGHAARIIAYDDADLMLAGGAEKACTPLGIGGFGAARALSKR-NDNPQAASRPWDKDRDGFVLGDGAGIMVLE-----E------YEHAKKRGA-K-IYAEVVGFGMSSDAYHMTSPPDDGAG-AALSMENALRDA--------GI--SA-AKVGYINAHGTSTPAGDRAEAEAVKSVFDA----D---------------------------------------------------A--RR--VMVSST-----------------KSMIGHLLGAAGAVESIFSVLALRDQAVPPT-INL-DNPD--EGC--D-LD------------FVP---------H---E-A----RQVK-----------G-MEYTLCNSFGFGGTNASLVFRKL-------------- 177 -------------------------------------------------------------------------------------------------------------------------MT--HRRVVITGMGAVSPLGCDIETIWKRL-LAGQSGVGVL--PA-EIC------------ETLTVKIGGQVLSLE----QDPE-SG-F----DPD----LHVLPKDQKKMDRFILFAMAAADKALAQSGFK-AETPE--QQ---E----------RAATVIGSGIGGFPAITNAVR--------------------------TND-Q-RGPKRLSPFTIPSFLVNLAAGQVSIKHQFKGPIGAPVTACAAGVQAIGDAVRLIRNDEADVALCGGAEATIDTVTLGSFAAAKAMSTGHEDHPEKASRPFDSARDGFVMGEGAGILVIE-----E------LEHALARGA-K-PLAEIIGYGTSGDAYHMTSGAEDGNG-AGRAMKIALRQG--------GL--KP-EQVDHLNAHATSTPVGDLGEINAIKNLFG-----T---------------------------------------------------G--DK--LAITST-----------------KSATGHLLGAAGGLETIFTVLAVRDQIVPPT-LNL-DNKD-PAAE--G-LN------------IIG---------N---T-A----QPHE-------------INYALSNGFGFGGVNACVLLKRWE--A---------- 178 -----------------------------------------------------------------------------------------------------------------------------MRRVVVTGLGALCPLGATVQEAWSNV-TAGRCGLSKLE--G-PE-----------Y-AELPCRVAGFVQANG----E-----Q-F----QLQ----QHFSKSQLRSMAPATGYALLAAAEALQDAGLL-P-MAPA-E-R--E----------RTGVAVGMGMIDLQDVCATF---------------------QA-----LQ-R-G-YHHVSPFFVPRILPNLAAGQISIKYGFQGPNHAVSTACATGAHAIGDSFRFIQTNSADVMVCGGTEACISPLAIAAFCRLRALSTSFNETPERASRPFDKSRDGFVMGEGSAILVLE-----E------LERAQRRGA-H-IYAEVLGYGLSGDAAHLTAPSPEGTG-AFLAMQRALLDA--------QL--RP-EDIGY----------------------------------------------------------------------------------------------------------------GAHGHLLGAAGNLEAVFTVKAIEEGVLPPTI-NL-DSVE---D-P-Q-L-------N-----FVA---------G---E-R----QLWGAP----A----G--RTALKNAFGFGGTNASLCLGQLR-T----------R 179 ------SH---------------------LRDHVNE-M---RVLGKCT---VLV-R------QTR---------------------------------------------S-----LST-PSG--RRRVVVTGSGAVTPLGNNGPDSWRRI-LAGESAISRLS----AE-----------F-KGLPCQVAAQIPRE-----------N-L----QLD----QHLTKSDIKLMSPATQLAVLAAEEALSTGKLC-P-KQLS-E-EELE----------RFGVCVGMGMFDLAEVYGAW---------------------NQ-----LQ-R-G-YNRVSPFFVPRLLPSMACGHISMRHGLRGPNHSVSTACATGAHALGDAMRFIRSGDADLMLAGSGEACIDPLSIAGFCRLRALSTAFNDNPAVASRPFDKSRDGFVMGEGAAVLLLE-----E------LEHARARGA-P-ILAEILGYGLSGDAYHITSPSDDGAG-ATLAMKRAIQDA--------GI--AP-EDVTYVNAHATSTPTGDRIESHAIGRVFG-----A------------------H--------------------------------T--PQ--VRVSST-----------------KGAHGHLLGSSGNLEALFVVLACANNKLPPSI-NI-EHLD-V-D-V-N-V---------------V---------T---K-A----TDWS-A---DQ----K-RRVALKNSFGFGGTNASLCIASYI------------- 180 ------------------------------------------------------------------------------------------------------------------------------KRVVITGLGLVCPLGTGAPLVWERL-ITGQTGIVALD--S-EE-----------F-ETIPCRVAALVPRGH----E--R-GQ-F----REE----SFVSRGEMSSMSPATVMALGAAQLALEDSGWH-P-STPE-E-Q--L----------GTGVAVGMGMVSLDEIARTSA--------------------------AFK-E-RGYNKVSPFFVPRILVNMAAGHISIRHKLKGPNHAVSTACTTGAHAIGDAARFIARGDAVAMVTGGTEACVEPLSLAGFARARALATRWNSNPAAASRPFHPEREGFVMGEGAAVLLLE-----E------MEHAVRRGA-R-IYAEVLGYGLSGDASHITAPAADGDG-AFRCMAAALSDA--------GV--SP-AQVTYVNAHATSTPLGDAAENAAIKRLFQG-----------------------S--------------------------------L--RS--LAVSST-----------------KGATGHLLGAAGALEAAFTALACYHAVLPPTL-NL-DRTE-P-QF--D-L----------N--YVA---------C---A-A----QPWL-------AG--A-PRVALSNSFGFGGTNASLCLASV-------------- 181 ---------------------------------------------MR---IKLI-Q------SIR------------------------------------------------N-Y-AS-PPT--RRRVVVTGLGVVSPLGSGTELVWHNL-LKGHSGIVALQ--G-EE-----------Y-SKLPCKVAGLIPVQQ----------G-D----GVS----KALSKSNLKSMAPATCLALLATSEALADAKWI-P-DSSE-D-R--E----------TTGVALGMGMIDLRDVCDTN---------------------DA-----LK-Q-G-YNKVSPFFVPRILPNMAAGHISIKYGFRGPNHAVSTACATGAHSIGDAFRFIRNGDADVMVCGGAESCISPLAIAGFCRLRALSTSFNDKPDLASRPFDKKRDGFVMGEGAAVLVLE-----E------YEHAVRRDA-K-MYAEILGYGLSGDASHITTPREDGSG-AVLSMSRALRDS--------NL--SK-EQVTHINAHATSTPVGDGIESTAIKTLFQ-----E------------------H--------------------------------S--RD--ICISST-----------------KGAHGHLLGAAGNLEAVFTVLACHQGVLPPTL-NL-DDAV-D-----D-L-------N-----YVA---------K---V-S----QEWKA----------E-RRIALKNSFGFGGTNATLCIGQL-------------- 182 --------------------------MSLALCQKLL-LNLA--EHRLLKA---R-TCV-GPGY--S-------------------------------------------TRRLSG-PAP-PKP--RRRVVITGIGLVSPLGTGTALPWGRL-IRGESGIVALD--P-EE-----------Y-KTVPCKVAALIPRGD----G--E-GD-F----RED----RFASRGEINSMSPATVMALGAAELALKDSGWY-P-TSPE-E-Q--L----------ATGVAVGMGMVSLDEIARTAT--------------------------AFA-A-KGYSKVSPFFVPRILVNMAAGHISIKHRLKGPNHTVSTACTTGAHALGDAARFIAHGDAEVMLAGGTEACVGPLAMSGFARARALATKWNDSPRLASRPFHPEREGFVMGEGAAVLVLE-----E------HGRALARGA-R-VYAEVLGYGLSGDASHITAPSADGDG-AFRCMSAALRDA--------SL--PP-EAVTYINAHATSTPLGDAAENAAIKHLFGG-----------------------H--------------------------------A--RH--LAISST-----------------KGATGHLLGAAGSLEAAFTALACYHGDLPPTL-NL-DRTE-P-EF--D-L----------N--YVP---------Q---R-A----QEWR-------PD--G-RRIALTNSFGFGGTNASLCLASI-------------- 183 ---------------------------------------------MS---AKLI-H------QIR------------------------------------------------T-I-TQ-SSQ--RRRVVVTGLGVVSPLGTGTELAWQNI-LKGQCGIVSLQ--G-NE-----------Y-SKLPCRVAGLVPLEK----------D-D----KVM----KALSKSNLKSMAPATCLALVATEEALADAKWF-P-KSDI-D-R--E----------STGVAIGMGMIDLKDVCDTN---------------------EA-----LK-V-G-YNKVSPFFVPRILPNMAAGHISIKYGFRGPNHAVSTACATGAHSIGDAFRFIRNGDADVMVCGGAESCISPLAIAGFSRLRALSTSFNDDPGKASRPFDKKRDGFVMGEGAAVLVLE-----E------YQHALERNA-K-MYAEILGYGLSGDASHITAPREDGSG-AVLSMSRALRDG--------CI--DK-EKVTYINAHATSTPIGDGIEATAIKTLFK-----D------------------H--------------------------------S--GN--ILISST-----------------KGAHGHLLGAAGNLEAVFTILSCHQGIIPPTI-NL-EEPV-D-----E-L-------N-----YVA---------K---E-S----KPWTV----------D-RRVALKNSFGFGGTNATLCIGQL-------------- 184 -------------------------------------------------------------------------------------------------------------------------MG--SRRVVVTGLGIISCLGCEVSVVWRRL-IDGHCGISSLT--G-KE-----------Y-EQIPCRIAGQIHRSTTEKGE--D-SA-I----NLE----KYVSLTEQRNLSLPTVYALVAAEKALNDAGWK-P-QSEN-D-S--L----------RTGVAVGQGMVDLEEIVTTGT--------------------------LLR-D-KGYRKVNPFFVPKILINMTAGHISMKYGLNGPNHAVSTACVSGLHSVGDAFRFIKNDFADVMVAGGVDATINPLAMAGFAKIRALSTRFNTRPHEASRPFDTLRDGFVMSEGCGLMVLE-----E------FDHAMQRGA-P-IYAEVLGYGMAAEANHITAPREDGYG-SYHSMRLALQEA--------KT--DP-TSVSYINAHATSTPLGDAAEIKAIRRLFGS-----------------------H--------------------------------S--KE--LFISST-----------------KGATGHLLGAAGSLEAIFSILALHTGTIPPTI-NL-ENPD-S-EF--EGL----------N--LVP---------K---V-K----TKFSE------SS--D-PRIALSNSLGFGGTTASICFSSV-------------S 185 --------M------SF---------LSLSYWAKIH-QRPH---SLGTLL---H-KSL--FSP--N-------------------------------------------QDSRHQ-FSG-QQS--QRRVVITGLGLVSPLGTGTGLPWENL-IKGQTGVVALD--S-EE-----------Y-KTIPCKVAALVPRGT----G--E-GQ-F----WGE----KFASRGEINSMSPATLMALGAAQLALEDSGWY-P-ESPE-E-Q--L----------NTGVAVGMGMVSLDEIARTSA--------------------------AFT-E-KGYNKVSPFFVPRILVNMAAGHISIKHKLKGPNHAVSTACTTGAHAIGDASRFIAHGDAVAMVTGGTESCVGPLSVAGFARARALATKWNDRPALASRPFHPERDGFVMGEGAAVLLLE-----E------LEHALTRGA-R-IYAEVLGYGLSGDASHITAPTADGDG-AFRCMSAALRDA--------GI--SP-SDVTYVNAHATSTPLGDAAENAAIKRLFQP-----------------------S--------------------------------F--DS--LAVSST-----------------KGATGHLLGAAGALEAAFTALACYHGVLPPTL-NL-NRTE-P-EF--N-L----------N--YVP---------C---R-A----QPWR-------TQ--G-RRIALTNSFGFGGTNASLCLSSF-------------- 186 -------------------------------------------------------------------------------------------------------------------------MT--RQRVVVTGIGLLTPLGFNISENWTNL-INGKSAIKQLV--S-EEAGQRVACLRFKY-QNLPSRVAGQIDRDK----L--V-ES-L----LAK----SIIRRSDLKSMSWANIFALAVADEAIKDSGWK-P-ENTN-Q---------------RAGTSIGTGMSGLLETSEAAI--------------------------NLN-NKKNYKTISPYFVPKILPNLSAGLISIKYKLNGPNHCVTTACAAGTHAIADAYNFIRNGLVDVMVCGATEACIHPVSMAGFSVMRALATKFNDRAKEASRPFDILRDGFVMSEGAGCLILE-----S------LENAKIRNA-K-IYAEILGSAINADANHITNPSANGDG-AFNCMTMTLEDS--------KV--RP-EELDYINCHATSTPAGDIAEMTAIKRIFKE----K---------------------------------------------------NLNHQ--VYISSM-----------------KGSLGHLLGAAGAAEVILTVLACKNKILPFNL-NL-ENVD-P-VL--E-M----------E--RAP---------QLNLI-K----KNYVCL-----PS--K-KIIALKNSFGFGGTNSSICLSSFD------------- 187 ------------------------------------------------------------------------------------------------------------------------MNT--MRRVVITGIGIVSPIGNTAAEVEASL-RAGKSGIVFSP--E-YAE------------HGFRSQVHGMP--------------Q-I----VLE----EHIDKRDLRFMGPGAAYNFIAMNQAVADSGLE-P-GDVS---N--E----------RTGIIVGSGGPSTSNFFQAHQ--------------------------IVIEK-GAPKRMGPFMVTRCMSSTNSACLATPFKIKGVNYSITSACSTSAHCIGNGVELIQMGKQDIVFAGGGEELDWTLSCL-FDAMGAMSSKYNDAPATASRAFDATRDGFVIAGGGGVVVLE-----------ELNHALARGA-K-IYAEVTGYGATSDGHDMVAPS--GEG-GERSMRLAVATL--------PEGR----KIDYINAHGTSTPAGDVTEVKAVRRVFGD-G---------------------------------------------------------NV--PPISST-----------------KSLTGHSLGATGVHEAIYSLLMLNGDFITASA-NV-TQLD-P-EL--KPE-------E-----IVT-----T---------Y----REG---------V--E-LDSVLSNSFGFGGTNATLVMSKYR------------G 188 -----------------------------------------------------------------------------------------------------------------------------MRRVVITGFGIVSCLGHDRASVRDSL-FHGRSGIRRNE--K-YAE------------MGFRSQVSGSI--------------TGL----DLD----ALIDRKQRRFMGDAAAYGYIAMQRAIEMAGLT-P-EQVI---N--P----------RTGLIAGSGGASSINQVEAAD--------------------------IAREK-GI-KRIGPYMVPRTMASTVSACLATAFQIKGVNYSIASACATSAHCIGNAAEQIQLGKQDIVFAGGAEEESWAESCM-FDAMGAMSSKYNDTPEQASRAYDANRDGFVIAGGGGMVVVE-----------AYEHAVARGA-T-ILAEIVGYGASSDGHDMVAPS--GEG-AERCMRQALATV--------D--T----PIDYLNTHGTSTPVGDVAELKAVRAVFG--D---------------------------------------------------------QA--PRISST-----------------KSLSGHALGAAGVHEAIYSLIMLGDDFIAASA-NI-SELD-P-EA--DGL-------P-----IVR-----A---------R----VDQ---------A--G-LRTIMSNSFGFGGTNATLVLRKV-------------- 189 -----------------------------------------------------------------------------------------------------------------------------MKRVVITGMGINSCIGNSLEEVTHSL-KNGISGTRFNP--T-YAE------------LNFKSHVSAAA--------------V-Q----DF-----DGIDRKLKRFMGVCAMYAYNAAIAAVEHAGLK-Q-EDLA-N-N--P----------RYGIAGGSGGNSTASVAEMVK--------------------------LLEEK-GA-RKIGPFFVPRNMSNTITANVGVALKLQGIAHSITSACATSADAIGYAYNLIQLGKQDLMLAGGGEEDHWSQSLL-FDAMGALCSKYNDTPETASRPYSADRDGFVIAGGGGFVVLE-----------SLEHAQARGA-N-ILAEVVAYAANSDGADMVAPS--GEG-ATRCILMALDEA--------K--QHGIEQIDYINTHGTSTPAGDVTELKAMERAFGE-G---------------------------------------------------------NV--PALSST-----------------KSMTGHSLGAAGVQEAIYSVLMMQNDFIAPNI-NV-TELD-E-GA--KGF-------D-----IVL-----E---------K----RD----------A--K-LNTVMSNSFGFGGVNACLIFKKWD------------A 190 -----------------------------------------------------------------------------------------------------------------------------MKRVVITGMGINSCIGNSLEEVTHSL-KNGISGTRFNP--T-YAE------------LNFKSHVSAAA--------------V-E----DF-----DGIDRKLKRFMGVCAMYAYNAAIAAVENAGLK-Q-EDLA-H-N--P----------RYGIAGGSGGNSTASVTEMVK--------------------------LLEEK-GA-RKVGPFFVPRNMSNTITANVGVALKLQGIAHSITSACATSADAIGYAFNLIQLGKQDLMLAGGGEEDHWSQSLL-FDAMGALCSKYNDSPETASRPYSADRDGFVIAGGGGFVVLE-----------SLEHAQARGA-K-ILAEVVAYAANSDGADMVAPS--GEG-ATRCILMALDEA--------K--QHGVEKVDYVNTHGTSTPAGDVTELKAMERAFGE-G---------------------------------------------------------KV--PALSST-----------------KSMTGHSLGAAGVQEAIYSVLMMQNDFIAPNI-NV-TELD-E-GA--QGF-------D-----IVL-----E---------K----RD----------A--K-LNTVMSNSFGFGGVNACLIFKKWD------------A 191 -----------------------------------------------------------------------------------------------------------------------------MRRAVITGIGVVSSIGNNKEEVLESL-KQGRSGIAFNQ--E-FAD------------YNLRSNVSGKI--------------D-I----DVK----EFVDRKSMRFMGDAAAYAYISMSQAIADAGLS-E-DQVS---N--E----------RTGLLVGSGGGSSKWQVEAAD--------------------------ILREK-GV-KRVGPYMVPRTMASTTSACLATPFKIKGVNYSLSSACATSAHCIGHAVEQIQLGKQDVIFAGGGEELHWTLAME-FDAMGALSTKYNETPEKASRTYDANRDGFVISGGGGIVVVE-----------ELEHALARGA-H-IYAEITGYGATSDGYDMVAPS--GEG-AVRCMKQAMQGL--------E--G----GIDYLNTHGTSTPVGDVKELGAIQEVFG--G---------------------------------------------------------NS--PMISAT-----------------KAMTGHALGAAGVHEAIFSLLMLEHNFVAPSI-NI-DELD-E-QA--TGL-------N-----IVT-----E---------R----KD----------V--E-LNTVMSNSFGFGGTNATLVMSKYK------------G 192 -------------------------------------------------------------------------------------------------------------------------MK--SRRVVVTGLGLVSPLGTKVQYAWKRL-LAGESATTKLD--A-PE-----------Y-ASIPCKVAALVPRGT----D--E-TS-F----DID-----AVSKSDRKYLSLSMIYALHATEQALTDAKWK-P-GSKA-E-K--E----------RTGVCLGMGMVDLQDVLSTG---------------------SD-----LN-R-G-YSKVSPFFIPRILPNLAAGHVSLKYGFQGPNHCVSTACTTGLHAIGDASRFIQYGDADVMVCGATEAAVNPLSIAAFARMRALSTGFNEDPQSASRPFDVRRDGFVMGEGSGVLVLE-----E------LSHAEKRGA-K-IYAEVLGYGLSADAYHITTPREDGGG-AILCMSRAMEHS--------GV--QP-EEVGYVNCHATSTPIGDKVEAGAIAMMFVG----D------------------P--------------------------------L--ET--LSVSST-----------------KGATGHLLGAAGAIESVFTVLACHTGDIPPTA-NL-KYLD-P-AIH-K-L-------S-----IVS---------K---S-S----VRWDPK----F----R-RRVAIKNSFGFGGTNASICFAQMT------------- 193 ---------------ML---------SNCLQKFLKA-T---SSHPY-PAS---C-CWL-MN-K--R-------------------------------------------KFSGTM-P-A-AKS--RRRVVITGIGLVTPLGVGTQLVWDRL-LRGESGIVSVV--G-DE-----------Y-KNIPCSVAAYVPRGT----D--E-GQ-F----NEQ----NFVSKSDTKSMSSPTIMAIGAAELALKDSGWH-P-KLEA-D-Q--V----------ATGVAIGMGMVPLEVVSETAL--------------------------MFQ-T-KGYNKVSPFFVPKILINMAAGQVSIRYKLKGPNHSVSTACTTGAHALGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALST--NPDPKLACRPFHPDRDGFVMGEGAAVLVLE-----E------HEHAVQRGA-R-IYAEVLGYGLSGDAGHITAPDSEGEG-AFRCMAAAVKDA--------GV--LP-EQISYVNAHATSTPLGDAAENKAIKKLFRG-----------------------H--------------------------------T--GA--LAISST-----------------KGATGHLLGAAGAVEAAFTALACYHQKLPPTL-NL-DCTE-P-EF--D-L----------N--YVP---------L---E-A----QEWK-------TE--D-RCIGLTNSFGFGGTNATLCIAGM--------------