575 937 1 ------------------------iavvgigckvp-g-a---dnvdqfwqlle-rgenhv-veip-k--d-rw-nnea--fyd----pdpiavgks-yvqkagll-----k-d--pl-afdnklfnindf-eadqmdpqqrlvcecsymaledggfpr--------eqlag--srtgvyv---------------------------------------g-amnady--rslf-sg-----------n----t--a-ivnnytvtgvsnsiiaarisfifdlrgps------ltldtacssgllavhlgaqalrtrdcdmalcggtnffvlp-dtfvhlskarmvsptgqcfafsdrad--------------------------------------------------------------------gytrgegcgmvlikrlk-d--------------a--lrdgdhiwa-tle-tssn--qdgravt-------p---isapsgeqqikllehiyet-a-gida-kcidyieahdniiarriddmsedietdvletmciskkvalqldestdisghcqllanmrfvdggairenflcraskcwpvct-gtaa------g------dpvevnalg-sffk-tq---g----a------------------------------------------------------------e-----r-qrhigsvktn-vghlesaagtaglikvllmmkhskivpslf-fd-----r--pnpkid-feglklnvpt--kvl-nwlt--p-------kkvacvnsfg-mggtnchava--------------------------------------------------------------------------------------------------------- 2 ------------------------iaiigigcklp-g-a---dncdefwqvle-rgenhv-vdip-k--e-rw-ntda--fld----kdkhavgks-yvqragll-----k-d--pl-afdnklfkimdf-eadlldpqqryvlecsymamedagltr--------hdlag--sktgvyv---------------------------------------g-amnsdy--rsls-sg-----------k----s--p-lvdgytvtgtsssmisarvsyvfdlrgpa------ivvdtacssglvaihvagqalktgdcdmafcggtnfimsp-dvfvhlskanmlspsgqvhtfsdkad--------------------------------------------------------------------gytrgegcgmiilkrlq-d--------------a--ktdgnyvya-tik-tgsn--hdgrtvs-------p---isapseeqqsmllheiydq-s-giel-dsleyieahgv----------------------------------------------------hkdsnnlilltlqlillgt-gtpa------g------dpvevnalg-kffq-sk---n----s------------------------------------------------------------v-----c-srfigsvktn-ighlesaagiaglikvllmmkhlkivpslf-fe-----k--pnpkid-fegmkfkvpt--eli-dwpt--q-------ekiacvnsfg-fggtnchaiiks------------------------------------------------------------------------------------------------------- 3 ------------------------ICITGMSGRVGQ-C----KNLDEFKDILM-KGKDAF-T--D-K--SMRF-DID---KY-------------G-TQKEHAYFE--------EAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEAAYEAVVDSGYSM--------QEVRGT--LTGVYA----------------------------------------SVCTLDA--SNYW-LS---K------------TLDA-ITEASKGLGVIHNFRASRVSYAMDLRGPS------MCVDTACAGYLSAIEAAVKDIRLGNCDRAIVVTSQLEANP-MSEQHFMDLGLSGPNSKCFSFDERAE--------------------------------------------------------------------GFARGEAMGAIMLHKEE-E----------------ARR----IYAK-VAHGYQS--CDGNSGD-------FALEFSTPSFYGQIDTLKECYRQ-A-GVDP-QTIEFVECHG-----------------------------------------------------------------------L-GTKV------------GDTTEANAIT-EVFC-GK-Q---R----------------------------------------------------------------T----K-PLIIGSVKTN-AGHADAAAGFNATIKCVMALNEGVIPPNLN-FE-----K--PNKEIPGLHDGRLKVPV--EPT-PWSG--D---------MCGISAYS-YGGTNTHLILKK------------------------------------------------------------------------------------------------------- 4 ------------------------VCITGISGRVGQ-C----NNLDEFKDVLW-NKKHAF-T--D-K--PLRY-DFD---KY-------------Q-TGNWYSYVN--------NVDK-FDPEFFNIDLK-KANYIDPNIRLGLEHAYEAIVDAGYSI--------EEMRGS--KTGVYA----------------------------------------SCVGYDA--SNFW-NY---L------------TADE-LGEGS--LGHHNSFRASQISYALDLRGPS------MALDTACSGFLAALQMGMMDIRLGNCDQALIVGSQLQANP-WGAKFFKDIGAASPDGVNRNFDDKAN--------------------------------------------------------------------GMSRGETVGVMLLQREE-D----------------ARR----IHTK-VVHALQG--CDGNSGA---------HDFNHPSATGQIETIAHCYKQ-A-GIDP-QTIPFVECHG-----------------------------------------------------------------------T-GTKA------------GDGAEGESVD-TVFT-GD-N---R----------------------------------------------------------------K----E-PLWIGSVKTN-VGHAEAAAGFNSVAKCIFGFRENVIIPNIN-YD-----T--PSRAIPGLIEGRLRVPV--DFI-PWDN--T-R----HGIICGVTGFG-LGGNDSHAILKK------------------------------------------------------------------------------------------------------- 5 ------------------------ICITGMSGRVGQ-C----NDLAEFKDMLW-SKKDAY-T--D-K--PMRY-SLD---KW-------------S-DQKEHAFMN--------GCEY-FDNEYFGIAAR-VTEYLDPQVRMNMEASYEAMIDSGYSP--------AELRGS--NVGVYV----------------------------------------AASNYDA--LSYW-QT---L------------GLKD-QREATKGLGSTANFRATRVNYTFDLRGPG------QLIDTNCNGYLAAIDLAIKDIRLGNCCAAFVGVTSLHVNP-LSSELLFQRGMIGENSRCFSFDERAE--------------------------------------------------------------------GFGRGEAVGFLFLQKEE-D----------------ARR----IHAK-IVHSYQN--SEGSNGG----------EFCTPSSKGQIEAMTECYKE-A-NIDP-QNIDFVEAHG-----------------------------------------------------------------------I-GCKD------------WDATEMEAIT-EVFC-SK-K---R----------------------------------------------------------------S----K-PLMIGSVKSN-VGHTECAAGFPSIAKCVFGMKEGMVPPSIN-YK-----T--PSKDIAGLHDGRLSVPT--ELT-QWKG--E---------FCGVNSYS-FGGNNAHLILKK------------------------------------------------------------------------------------------------------- 6 -------------------------CITGMAGRVGQ-A----MNLAEFSEALL-NKKDVF-T--D-E--FTHF-DCD---KF-------------A-CQPRHAYLK--------NHSK-FDADYFNISKK-NANNLDVNVRLGMEAAYEVIADAGYSA--------EEIRGT--KTGVYV----------------------------------------SCVAYDI--SAFW-QF---K------------TLDE-MGENS--LGNRESFRASRIAHAFDLRGPN------QILDTACSGYLAAIETAMKDIRLGVCDSAIVLSSQLHMNP-MAEMLFLSIGAAGSSGVCYAFDERAA--------------------------------------------------------------------GLARGETVGAMFLQKEE-D----------------ARR----VWIK-LIHAYQA--ADGNSGD---------FDFNRPSAVGQMECMNECYRQ-A-NIDP-QTMGFVECHG-----------------------------------------------------------------------T-GTAA------------GDGTEGDALS-RVFL-GD-R---R----------------------------------------------------------------T----E-PLTIGSVKSN-AGHAEGAAGFNSMFKCILGLNNSVIIPNIN-YE-----R--PNPNIPALVDGRMRVVS--EVT-PYPH--D---------TVGINGFG-LGGTDSHVIIKK------------------------------------------------------------------------------------------------------- 7 ------------------------VAISGISGRLP-E-S--D-NLAEFREHLM-KKENMA-TE---DDR--RW-KV-------------GL-H--G-LPPRNGKVK--------EVRH-FDAGFFGVHPK-QANRMDPQLRMLLEVSYEAIIDAGQSI--------ESVRGS--RTGVFI---------------------------------------G-VSQSDA--SDGW-TL---D------------A--E-TLVGYTMPGCCRAMFANRISYFFDFKGP------S--------------------------------------------------------------------YSVDTACSSSMMCLDQALLNIRMGIIDAAIVGGTNLCLKPNVSLQFVRMNMTSPD-GACKTFDAKGDGYCRSEAIMAIYLQKTA-D--------------C--RR----IYA-TVVHAKSN--CDGYKEQ-------G---ITFPSGILQKQLINEVYHE-I-GINP-TDIAYIEAHG-----------------------------------------------------------------------T-GTKV------------GDPQETNTIV-DVFC-K--G---R----------------------------------------------------------------K----E-PLLISSTKSN-MGHPEAASGLSSIAKIIISMEDKIIPPNLH-F---E--T--PNPDIPGLLDGRLKVVT--ECT-PWNG-----------GLVAMNSFG-FGGANVHAIYRSH--D--KE--L-T------E----PHE--AS-Q-------------------------K------VRLFTCSARTEEGVKAVL-------------------- 8 ------------------------LVISGVSCRLP-E-S--E-NMEEFEQHLM-NGEDMV-TE---DDR--RW-QPGL--------------F--G-LPKRSGKLK--------TLKK-FDATFFGVHPK-QANSMDPQLRMLLEVTYEAIVDSGTNP--------SSIRGS--KTGVFI---------------------------------------G-ASASEA--HEAW-AM---D------------P--Q-KTVGYSMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------FALDTACSSSLLALDQAVNSIRQGHCDAAVVGGCSLCLKPLTALQFLKLGMLSPD-GSCKSFDASGNGYCRSEGIVVVYLQMEP-E--------------A--KR----IYS-TVVHTKTN--SDGNKEQ-------G---ITFPSGQIQKRLLYDVYEE-A-GVAP-NKVVYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNSIV-DVFC-K--D---R----------------------------------------------------------------N----G-PLPIGSVKSN-MGHSEPASGLAAVAKVVVGMERGIMPANLH-F---K--E--PNPDIPGLTDGRLQVVT--QNM-PLRE-----------GFVGVNSFG-FGGSNVHAILKSS--D--VK--R-E------N----NHK--AS-N-------------------------A------KRLFVYSSRTSDGAEKIL-------------------- 9 ------------------------VVITGISGRLP-E-S--T-NIAEFRENLI-QGIDMV-TE---DDR--RW-SPGM--------------Y--D-LPKRCGKLK--------ELDK-FDAAFFGIPPK-QADAMEPQLRMLLEVAYESIVDAGVDP--------HSIRGT--KTGVFV---------------------------------------G-ASESEA--HQAW-SS---D------------P--E-TTVGYHMTGCARSMFANRLSYYFDFKGP------S--------------------------------------------------------------------FVMDTACSSSLLAMDQALASIRLGLCDSAIVAGTSLCLKPTTSLQFKRLNMVSED-GCCKSFDASGSGYVRSEAVVVVFLQKAK-S--------------A--RR----IYA-TLVHTKNN--ADGNKEQ-------G---ITFPSGEIQKRLLTEVYQE-A-GIDP-KTVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQELNSIT-DVFC-K--G---R----------------------------------------------------------------E----G-PLLIGSTKSN-MGHPEPASGLAALAKVLIAMEDGMIPANLH-F---K--E--PNPDIPGLSDGRLKVVT--ERL-RWNG-----------GYVAINSFG-FGGSNVHALLRSY--P--VE--K------T-T----PHP--AS-E-------------------------L------PRLATFAGRTEESVAKML-------------------- 10 ------------------------IAVVGIGCCTA-G-A---SNIREFWRVLE-KGDCHV-TDVP-A--N-RW-NAAA--FLS----DKPQAFGKA-YVQKGGFV-----Q-D--IY-GADNTLYGINEY-EASQMDPQQRMLLECTTMALEDAGLTR--------SHLRQ--SNTGVYI---------------------------------------G-SMNNDF--GALY-GG-----------R----G--S-GTDSYTATGLSNSILAGRISYIWDLKGPS------MVLDTACSSSLVALHQGCLAIRAGDCDMAICGGVNCMLTP-DMFEKLSKTRMLSPTGLCHTFSDKAD--------------------------------------------------------------------GYIRGEGCGVIVLKPLK-D--------------A--IRNGDRIRA-LVY-TGTN--QDGHATT-------S---ITAPSGEQQKNLLRSVYHR-Y-NVDV-NQLDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEVNALG-SFFT-ES---G----P------------------------------------------------------------R-----R-QRYIGSVKTN-IGHTESAAGILGVIKVLLMMEHEQIVPSLH-C---D--P--VNPKLN-MEAHAFLIPR--TPL-PWTV--P-------DKMAACNSFG-FGGSNAHAVIKSYD----VG--H-D------S---T-AQ--QQ-T-PQQQ----------QLY-----K-W------PCVVCFSGKSQKSLRGTL-------------------- 11 --------------------------------------------MDEFWRVLV-NGENHV-VDIP-A--D-RW-NAQA--YYD----PDPMAPGKS-YVRRAGLI-----R-A--PD-EWDNRLFNINDF-EMNQMDPQQRLVLDCTYMALENAGITR--------AHLAG--SDTGVFV---------------------------------------G-AMNSDY--RGLF-TA-----------A----S--T-IVGNYTATGVSNSIIAARVSYVFDLRGPS------ITVDTACSSALVSIHLGAQAIRSGDCSLAICGGTNYLTLP-DVFVHLSKAHMLSPTGQCHAFSDKAD--------------------------------------------------------------------GYTRGEGCGILILKRLK-D--------------A--ERDGDNIWA-TIL-TGSN--QDGRSVT-------P---MTAPSMSQQVRLLEQVYTN-A-NIDI-DRLDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPIEATAVG-NFFK-DH---G-A--M------------------------------------------------------------G-----R-VRYIGTVKTN-LGHLESAAGAVGIIKVLLMMRHSLIVPSLH-FA-NN--N--PNPRID-FEDLQLQVPT--KVL-EWNR--E-------NKIGCVNSFG-FGGTNGHCILIEYT----KH----------------------------------------------------------------------------------------------- 12 ------------------------IAVIGVGFKGP-G-A---DNLEQLWMVLE-NGENKI-SEIP-K--D-RW-NSDA--FYD----SDPEATGKY-YSRKAGLL-----S-N--PH-EFDCSFFNISEI-ESEQMDPQQKFVLECTYRAMEHAGITR--------DKIKG--SKTGVYI---------------------------------------G-AMNCDY--RGMF-PA-----------R----S--A-GVSNYTVTGISNSIIASRVSFTFDLRGPC------LVLDTGCSSALIAIHTASHALTLGDCSMAICGGTNFMATP-DVFVHLSKAQMLSRSGQCHAFSDQAD--------------------------------------------------------------------GYTRGEGCGIVILKKLS-D--------------A--ERDNDPILA-VIT-TGTN--QDGHTVT-------P---ISAPSMSQQIQLLEDMYRD-L-SLEQLDEIEYIEAHG-----------------------------------------------------------------------T-GTQA------G------DYAEANALG-QFYK-NK---G----S------------------------------------------------------------S-----K-KRLIGSIKTN-IGHLESAAGAAGLIKVILMMEHNKIVPSLF-SE-----R--PNKRIN-FDDLNLVVPP--KVR-EWST--E-------KKVACVNSFG-FGGSNCHAIVRSYK----AP--N-S------G---Q-HK---------S---------------------------------------------R-------------------- 13 ------------------------IAIIGIGFKGP-G-A---ENLEQLWEVLE-GGKNYV-LDLP-K--D-RW-NVDA--FYD----PDPQATGKY-YTRKAGLL-----S-N--PL-DFDNTFFDINDI-ESDQMDPQQKFVLECSYRAMEHAGITR--------RSIQG--SKTGVYI---------------------------------------G-AMNCDY--RGLF-PV-----------G----Y--S-VVSNYTVTGVSNSIIAARVSYAFDLRGPC------MVLDTGCSSALLAIHTASQALLNGDCTMAICGGTNFIGSP-DIFIHLSKAQMVSPTGQCHAFSEQAD--------------------------------------------------------------------GYTRGEGCGIVLLKKLS-D--------------A--ERENDKILA-VIT-TGTN--QDGHTVT-------P---ISAPSMSQQIQLLEDMYRD-L-SLEQLDEIEYIEAHG-----------------------------------------------------------------------T-GTQA------G------DYAEANALG-QFYK-NK---G----S------------------------------------------------------------S-----K-KRLIGSIKTN-IGHLESAAGVVGLIKVLLMMQHNKFVPSLF-SE-----S--LNKRID-FEALNLVVAS--QVK-DWTT--E-------NKVGSVNSFG-FGGSNCHAVVRSVV----QR--D-C------K---K-AE---------TT----------NQV-----N-K------ACVVCFSGKTVTS----L-------------------- 14 ------------------------IVIVGIGCKFP-G-A---ENKDEYWKVLL-NGENHV-IEVP-P--E-RW-KIDH--FYD----SDPDAPGKT-YVRRAGFI-----K-S--YD-EWDNRFYGISDV-EAERMDPQQKYILDCVQMALEDGGFTR--------KQIAA--SNTGVYI---------------------------------------G-AMNDDY--KMAY-SE-----------D----L--K-VTDNYSLTGSSSSLMSARVSFVYNLQGPS------MVIDTACSSSLVAMHVAAQAIKSGDCTMAICGGVNCIMYP-DMFIPLSKARMVSPKGQCQAFTADAD--------------------------------------------------------------------GYARGEGCGIVILKQKK-L--------------A--ISDRNKIWA-EIS-TGCN--QDGHVAT-------P---ITAPSGDQQEKLLQKVYSK-N-NINV-ADVQYIEAHA-------------------------------------------------------------------------------------------------MV-KKQT-KR--G-W----------------------------------------------------------------E-----H-PVYL-------VVGEKMRSGVTEIFLCWGAAK-GKISRHLS-LLAIV--D--FDMKII-NNKPSLIIET--S---QRKY--V-F--N-TSTAEVVESW--------ISLLKREI----------------------------------------------------------------------------------------------------- 15 ------------------------IAIIGVGCRFP-G-A---DNIDEFWKVLL-HGENHV-VDIP-N--D-RW-NVDA--IYD----ADPDAPGKT-YVRKAGLI-----V-G--HD-TWDNNFYGISDL-EAEKIDPQQRLVLDCVHMAMDNAGVRK--------TDLNW--SSTGVYI---------------------------------------G-TMNDDF--THGM-NE-----------N----P--G-ELTNYSVTGSARSIISARVSYLYNLLGPA------MTIDTACSSAVVAIHTGIHAIKMGDCNMALCGGVNSILYP-ELFIALSKARMLSPTGQCQPFSAKAD--------------------------------------------------------------------GYARGEGCGIILLKKLT-D--------------A--LKDGDYIWG-TII-TGCN--QDGHTAS-------P---MTAPSLSQQKHLLEKVYRE-N-NVDP-CSVQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEVDSLG-TFFM-EH--RA-K--HT--------------------------------------------------------D--L-----K-KLLIGSVKSN-IGHTESAAGVAGIIKILLMMKNETIVPSLH-SE-E------LNPKIH-FDTYGLHVVQ--NCT-PWEQ--N-A--S-KRRVACVNCFG-FGGTNSHAIVEQDL----K--TQ-Q---PH-T---S-L--------EN---LDTK-E-----------G-R------PYIIAISAADNWSLEQI--------------------I 16 ------------------------IVITGISCRLP-E-S--D-NMAEFRQHLV-LGEDMV-TE---DNR--RW-EPGY--------------L--G-LPKRNGKLK--------DLSK-FDAAFFGVHPK-QANAMDPQLRMLLEVTYEAIVDSGYSP--------QSVRGS--KTGVFI---------------------------------------G-VSASEA--GEAW-AA---D------------P--E-TLVGYSMTGCCRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLLALDQAIASIRAGNCDSAIVGGSNICIKPTTALQFLKLGMLSPD-GMCKSFDASGNGYCRSEGIVAIHIQKVS-S--------------A--RR----IYS-TLVHSKNN--ADGGKEQ-------G---ITFPSGEVQRQLVEDTYRE-A-GVDP-SQVSYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNSIV-NVFC-K--G---R----------------------------------------------------------------R----Q-PLLIGSTKSN-MGHPEPASGLAAVAKVIIAMEDKVLPANLH-F---N--E--PNPDIPGLLDGRIKVVT--EGT-RWSG-----------GYVGINSFG-FGGANVHTILKSN----DNE--K-S------V----NHP--AS-T-------------------------S------RRLCIYAGRTEDSVAHVL-------------------- 17 ------------------------IAIVGIGCKVP-G-A---DNIREFWRVLL-HGENHV-VDIP-N--S-RW-NAEA--YFD----ADPMAPGKS-YVKRAGLV-----N-G--HD-EFDNKVYSINDF-EAAQMDPQQRFVLDCTLMALEDAGLTR--------AHIAG--SNTGVFI---------------------------------------G-AMNSDY--RGLY-NA-----------H----S--S-NVGNYTVTGISNSIISARLSYVFDLRGPS------LVLDTACSSSLIGMHLGCQAIRAGDCDMAIAGGTNYMTIP-DIFVHLSKARMISPSGQCHSFSSKAD--------------------------------------------------------------------GYTRGEGCGIVILKRLK-D--------------A--VRDGDNIWA-TIY-TGSN--QDGHSVS-------P---ITAPSGMAQKSLLDSIYTK-V-GLDL-GRIDYIEAHG-----------------------------------------------------------------------T-GTNA------G------DPVEVNALG-EFFK-TF---A----K------------------------------------------------------------P-----R-QRYVGSVKTN-IGHLESAAGVVGVIKVLLMMKHGKIVPSLH-CE-----E--PNPKIN-FPDLMMTVPG--KPV-DWEN--P-------DKVACCNSFG-FGGSNSHAVLCYYR----PN--P-S------N---A-KQ---------MVSE--------AQS-----R-R------PCVVCFSAYTEKSLRAMM-------------------- 18 ------------------------VVITGISCRLP-E-S--D-NMTEFRQHLM-LKEDMI-TD---DDR--RW-QPGF--------------L--G-LPRRNGKLK--------DLSK-FDASFFGVHPK-QADAMDPQLRLLLEVAYEAIIDSGYSP--------QSLRGS--KTGVFI---------------------------------------G-VSASEA--GEAL-SA---D------------P--E-TLVGYGMTGCCRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSSLAMDQALASIRAGICDAAIVGGSNICIKPNTALQFLKLGMLSAD-GCCKSFDANGDGYCRSEGIVAIHIQKVS-A--------------A--HR----VYT-TIVHSKNN--ADGNKEQ-------G---ITFPSGAVQKQLLEETYHE-A-GVDP-SQVAYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNSIV-DVFC-K--D---R----------------------------------------------------------------N----E-PLLIGSTKSN-MGHPEPASGLAALAKVVIAMEEKIVPANLH-Y---E--E--PNPDIPGLVDGRLKVVT--EGT-RWPG-----------GYVGLNSFG-FGGANVHLILKSN----DNE--K-C------E----QHP--AT-S-------------------------C------RRLCVYAGRTEECVDHVL-------------------- 19 ------------------------IAIVGVGCRAP-G-A---ENLDGYWRVLK-NGECHV-GDVP-P--S-RW-NAAA--FLD----PDQTALCKA-YVQKGGFI-----T-D--VE-SFDNALYGINDY-EAVQMDPQQFLLLDCTAMAMEDGGLTR--------KQLSG--SSTGVFI---------------------------------------G-AMNNDY--IGAY-YG-----------H----T--S-KVNTYTGTGISNAILASRVSYVFDLRGPC------LVVDTACSASLVALHQACLAIRAGDCSMAICGGVNCILSP-DMYIKLSKARMISPTGLCHTFSEDAD--------------------------------------------------------------------GYARGEGCGTVILKRLK-D--------------A--LRDGNKVWA-TIN-TGTN--QDGRSVT-------P---MTAPSGDQQKELLHSIYSK-W-QVDV-SQLDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEVNALG-SFLK-ER---D-S--P------------------------------------------------------------P-----R-SRYIGSVKTN-IGHTESAAGVLSLIKILLMMKHNTIVPSLH-C---H--T--VNPKLN-LQSWQFIIPK--ELV-PWDS--P-------NKLAACNSFG-FGGSNAHAVVYSFP----SS--Q-S----------A------Q-E-PADT----------FRR-----I-------KYSLVCFSGKSQKGL---K-------------------- 20 ------------------------IAIIGIGCRTA-G-A---DNQWEFWRLLE-NQECHV-GDVP-S--D-RW-NTVA--YSDS---KVRNGRERP-FVQKGGFL-----K-D--VW-SFDNLLYRISDY-EAAQIDPQQFILLECTTMALEDAGITR--------RDLAG--SRTGVYI---------------------------------------G-GVHHDY--ATTF-VG-----------Q----V--S-TVDQYTVSGITNTILASRLSYEFDLRGPC------MVLDTACSVSMVAIHQSCLAIRSGDCDMAICGGVNCILTP-HIFMLLSEAWMISPTGQCKAFSKDAD--------------------------------------------------------------------GYTRAEGCGVLILKRLK-D--------------A--IRDGNKIYA-TVY-TGTN--QDGRTVT-------P---MLQPSGQQQLNLLRDVYSR-H-NVDV-TKIQYFEAHG-----------------------------------------------------------------------A-GTPV------G------DPVEANALG-TFLK-EK---G----H------------------------------------------------------------K-----G-TVYMGSVKTN-IGHTEAAAGILGVIKILLMMRHNKIVPSLH-C---D--E--VNPKIN-LTDLGLKIPR--EVI-HWDS--K-------NKIAGCNSFG-FGGSNGHAIIKECN----VM--Y-D----------Q------Q-I-RVT------------TK-----P-------NYHLVCFSGNTKRSVKGSL-------------------- 21 ------------------------IVIVGVGGKFP-G-A---DNIDEFWRVLR-DGENHV-REIP-P--D-RW-NMEA--FYH----ADPDEPGKT-YVRKAGLL-----K-G--YD-QFDNKQFGISDI-EAARMDPQQRYVLDSVHMALEDGGITK--------KEIYG--TQTGVYI---------------------------------------G-VMNDDY--RITC-CD-----------D----L--K-RTSNYTLTGTSPSIIPARVAYTYNLLGPA------MSIDTACSSSLVAIHVAAQALRCGDCSIAICGGVNSILYP-DMFVPLSRARMVSPTGQCQAFSNKAD--------------------------------------------------------------------GYARGEGCGILILKTRK-Q--------------A--ILDGSKVWA-SIA-TAVN--QDGRSTT-------P---ITSPSMVQQMNLLKQVYSA-T-GFDP-KKVQYLEAHG-----------------------------------------------------------------------T-GTPV------G------DPKEANTLG-EFFA-AS--NV-E--DD----E---------------------------------------------------C--P-----T-AVPIGSVKTN-IGHLESAAGVAGVIKVLLMMKHGKIVPSLH-VQ-T------PNPKID-LENYNLEIAQ--HLI-DWPY--L-P--EGRTRLACVNSFG-FGGTNSHAIIKQEE----I-----------------------------------------------------------------------------------------------N 22 ------------------------VVISGISCRLP-E-S--D-NIAEFREHLV-KGEDMV-TD---DGR--RW-EPGL--------------H--G-LPTRSGKLK--------DITK-FDCSFFGVNPK-QADAMDPQLRLLLEVAYEAIIDAGVNP--------QSARGS--RTGVFI---------------------------------------G-ASASEA--HEAW-ST---D------------P--E-KTVGYCMTGCQRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------FTMDTACSSSLLALDQALLNIRLGLCDAAIVGGSSLCLKPQTALQFMKLGMLSPD-GACKSFDSSGNGYCRSEGIVVILLQKRV-D--------------A--KR----VYS-TLLHSKNN--ADGNKEQ-------G---ILFPSGEQQKKLVTEVYAE-S-GVNP-AEVQYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNSIA-DVFC-P--G---R----------------------------------------------------------------E----G-PLLIGSTKSN-MGHPEPASGLAALAKVVVAMEDRVIPANLH-F---Q--E--PNPDIPALADNRLKVVT--EPT-PWNG-----------GLVAINSFG-FGGTNVHAVLKSN----SRK--A-D----Q-P----MHE--AA-E-------------------------K------KRLLICSSRTQEGLDEIL-------------------- 23 ------------------------IAIVGMGCRFP-G-A---DNLKEFWRVLV-NGENHV-VDIP-P--D-RW-AMEG--FYD----ADPNAPGKS-YVKKAGVL-----K-G--LE-YWDNTFFGINDV-EAKAMDPQQRLVLDCVHMALENGGITR--------RELNG--SSTGVYI---------------------------------------G-AMNDDF--NGVA-MD-----------D----L--T-LASNYKVTGTQRSIISARVAYVYNLHGPA------LTIDTACSSSLVAIHIGSQALRLGECNAAICGGVNCLLAP-SLFVALSKARMLSPSGQCQAFTDQAN--------------------------------------------------------------------GYARAEGCGIVILKRLK-D--------------A--LKDENEIWG-IVK-TGTN--QDGHMTT-------P---ITAPSGKQQLELLEHIYSY-F-NNGK-DSMQVIEAHG-----------------------------------------------------------------------T-GTAI------G------DPTEVNALG-SFFD-TT--S-SK------------------------------------------------------------K--R-----Q-QLFIGSVKTN-IGHLESAAGVAGLIKVLLMIKHKTIVPSLM-YS-VE--N--ENPKLN-LSKFGLKVPT--KCQ-DWET----E--L-NCRTACVNSFG-FGGTNAHAIVTEFH----SD--K------T-S---F-E------------------HT-NH-------M-Y------PSVVLLSAETKQSLT----------------------R 24 ------------------------VVISGISCRLP-E-S--D-NIEEFRQHLM-QGEDMV-TD---DDR--RW-QPGL--------------F--G-LPKRSGKLK--------DISK-FDASFFGVHGK-QANSMDPQLRMLLETTQEAIVDSGTNP--------NSIRGS--KIGVFI---------------------------------------G-ASASEA--HEAW-ST---D------------P--E-TTVGYSMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------FTVDTACSSSLLALDQAIHSIQQGHCEAAIVGGSSLCLKPTTSLQFQKLGMLSPE-GTCKSFDVDGNGYCRSEGIVSVFIQKRQ-A--------------A--KR----VYS-TVVHSKTN--SDGNKEQ-------G---ITFPSGEVQKQLLKEVYSE-A-GVLP-CNVSYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNTIA-ELFC-K--G---R----------------------------------------------------------------D----Q-PLLIGSVKSN-MGHPEPASGLAAVAKVIISMEDGIIPHNLH-F---K--S--PNPDIPALEDGRIKVVT--ENT-EFHG-----------GYVGVNSFG-FGGSNVHTILAS--NSKKTE--D-------------RHV--AS-D-------------------------A------KRLFVYSARSRAGLDTIL-------------------- 25 ------------------------VAVVGMSCRFP-G-G---EDLEEFWETLL-GGKDKV-TEVP-P--E-RW-DTAY--YYS----PDKEIPGKT-YSKHGGFI-----D-R--FD-EFDSRFFDISEK-EASRMDPQQRLLLECTFRALENGGFPL--------DVMSG--SDTGVYI---------------------------------------G-SMNSDF--SEVL-GN---------------SL--E-STDNYFATGTASSMLSNKVSYVFNLLGPS------LTLDSACSSSVMAIHLGAASILAGDCGMAVCGGVSVILSP-SVYVWLSKAKMVSPVGKCHSFSANAD--------------------------------------------------------------------GYTRGEGCGVVILKGLK-EA----------------IKDGDYIWG-IIG-TASN--QDGQTVT-------P---ITSPSSAQQMALLRNVYRK-Y-NVNV-KDIQYVEAHG-----------------------------------------------------------------------T-GTPA------G------DPVELNSLG-KVIS-SD--RN----P------------------------------------------------------------S-----D-PLVVGSVKSN-IGHLESAAGVASLVKVLLMMKNAKIVPSLH-SQ-P------PNDKIL-FKDYNLLIPT--QLL-DWPV--L-PHPH-GYRLACINSFG-FGGTNTHIVVRDYS----PQ--A-F------S---P-TV--QK----M----------------------S------RNIIPISAKTEEA-----------------L------- 26 ------------------------VVLSGISCRLP-Q-S--E-NMEEFKNNLM-NGVDMV-TE---DDL--RW-KPGT--------------Y--G-LPKRNGKLK--------DLSK-FDASFFGVHPK-QANSMDPQLRLLLEVTYEAIIDAGINP--------DLVRGS--RTGVFI---------------------------------------G-ASASES--HDAW-SL---D------------P--E-STVGYSMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------YTIDTACSSSLLALDQALHSIRSGQCDAAIVGGANLCLKPAVAVQFMKLGMLSPD-GMCKSFDAEGNGYCRSEGIVAIYLQRES-Q--------------A--KR----IYC-NLIHSKTN--SDGNKQQ-------G---ITFPSGDIQKRLLHEVYSE-A-CIDP-SQISYIEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIT-DVFC-K--H---R----------------------------------------------------------------N----T-PLLIGSVKSN-MGHSEPASGLAAVAKVIVAMEEGVLPGNLH-F---K--S--PNPDIPGLTNGKLHVVN--QNT-KWDG-----------GHVGVNSFG-FGGSNVHSILKSN----NNN--NNK----H-L----LCE--GN-E-------------------------K------KRLFNYCSRTEEGLKET--L------------------ 27 ------------------------VAIIGIGCRFP-G-A---NNKEEFWKLLL-NGENHI-TEVR-K--H-RL-GFES--YLV----SDPAEPNKK-HAYKAGLL-----D-R--FA-QWDNKVFGIQDQ-EAKWVDPQQRFVLDCVHMALEDAGITR--------QELSR--TNTGVYI---------------------------------------G-AMNDDF--RSAI-LE-----------D----A-DN-EDSSYMVTGLSLSIISARVSYVYNLFGPS------MTIDTACSSSLVAIHQGSLSLKAGECKMAICGGVNLILDP-RVFVSLANARMLSPSGQCHSFSSKAD--------------------------------------------------------------------GYTRGEGCGIVILKQLH-D--------------A--IRDGNKIWG-LIG-TGVN--QDGHMVT-------P---ITAPSGEQQLALLRRIYGE-L-KVSA-SSIQVIEAHG-----------------------------------------------------------------------T-GTPV------G------DPVEANSIG-TFFN-EN--SS-S--D------------------------------------------------------------I--------KYIGSVKSN-IGHLESASGVAGLIKIILMMKNETIVPSLH-VK-EE--G--LNVKNN-LAKNRLIVPT--EPM-TWPM--V-V--G-RAKMACVNNFG-FGGTNAHAIVSEYI----QR--S-Q------K---D-KR---S-L---------------EKN-----D-E------PVIVLLSGTSLEGL---H-------------------- 28 --------------------------------------------------------------------------------------------------------------------D-EWDNRLFGISDA-ESERIDLQQRYTLECVHMALEDGGITR--------HEING--SNTGVYM---------------------------------------G-CMNDDY--KMAL-YD---DFKVGKTNE----R--E-RDANYTVTGMHSSIISARVSYVYNLHGPS------MTIDTACSSSLVAIHLGIQSIRSGEIEMAICGGVNSILYP-ETFIALCKARMMSARGQCHAFSDMAD--------------------------------------------------------------------GYARGEGCGVVILQKLD-T--------------A--LKKNRKVWA-IIT-TGCN--QDGSTMH-------P---ITAPSKQQQVELLRTVYEG-Q-NIDK-SKIQYIESHG-----------------------------------------------------------------------T-GTPV------G------DPIEANALG-NFFT-G---EN-K------------------------------------------------------------G--T-----R-KIPMGSVKSN-IGHLEAGAGVAGVIKVLLMMKYGLIVRSLH-ID-LE--KKNFNPKIN-FDQYDIRVPL--DNE-IWES--D-E--K-GQRVACVNSFG-FGGTNSHSVIQQIQ----VP--N------R-E---V-K--------EN-----MD-V-----------I-G------PHLICVSAADRVSLRGC--------------------L 29 ------------------------VAVVGIGCRFP-G-A---ENTAEYWRVLR-SGENQV-IDIP-E--E-RW-HERN----------------KS-SRTRAGLI-----EGS--EN-VWDYALHDISSY-EGREMDPQQKMVLDSVHMALENAGITK--------KQVSG--SDTSVFI---------------------------------------G-AMNNDY--RGLN-DD-----------T----T--T-QISNFQVTGGNNSLLSARVSYNFNLLGNS------VTVDSACSSSAVAIDLACNQLTSGKCEMAIAGGVNSILSP-DFCTRLLEVGIVSPSGTCHAFSDKAD--------------------------------------------------------------------GYVRGEGCGIVILKPLN-K--------------A--IEDNDRILA-TIV-TATN--QDGGTVS-------P---IMAPSGHQQVALMEKLYRT-N-DISP-DTVDYVEAHG------------------------------------------------------------------------TGTKI------G------DPVEAAALG-QFFK-RS--KS-N---------------------------------------------------------------------Q-SLLIGTVKTN-IGHLESAAGVASLIKVILMHQHQTLAPTLN-FD-----R--QSQVIP-LSEHNIEVVT--EVR-PWPT--N-N--R-SYLRSAVNCFG-FGGTNCHMIVTTDL----RS--T-L------F---D-HR--ET-G-N---S-------------------S------PRVVCLSAKNSVSLEEMV-------------------- 30 ------------------------IAIVGIACRFP-G-A---DDIDEFWEVLK-NGEDHV-QII-PK--E-RW-DTEA--INI----PNLNDDWKP-SARKSGLI-----K-D--SD-KWDNKFFGISDS-EAGWMDPQQCLALEVTYTALEDGGFTK--------EKLKG--TNTGVYI---------------------------------------G-VMNRDL--SFGL-N------------D----A-SH-EFNNFVVTGIATSVVANRISYHFDIRGPS------MTVDTACSSALVSIHLGSQAIQSGDCNMAICGGVNSLLTP-INYIVLNKARMISTTGKSHTFSADAD--------------------------------------------------------------------GYVRGEGCGMVILKSFK-KAME----------------DGDKIWG-IVM-SGCN--QDGKAST-------P---ITAPSGEQQKVLLQKIYSS-Y-DISP-STIQYIETHG-----------------------------------------------------------------------T-GTPI------G------DPTETNALA-EFFS-TE--Q--T---------------------------------------------------------------N-----N-KIPIGSVKTN-IGHLESSAGTAGLIKVLLMMKHKTIVPSLH-YS-EE--N--GNKGID-FNKIPLVVST--KLN-EWHP--H-F--D-GTRISCVNCFG-FGGTNSHAIIKQIK--------S------S-E---S-KA--EN-N-NL---PDLI-VA-IS--------AT------TPEALQA------------------------------- 31 -------------------------VIAGLSCRLPK--S---NNVEEFWDNLI-KGKDMI-E-------ETRW-PVG---LYD--------------TPPRAGLIK------D--ID-KFDARFFKFTD-TEADNMNPLLRHLFEVTYECIADSGIPL--------HVLSSN--TTGTYT---------------------------------------A-CFIPDN--DPL-ET---------------------SRC-ADSKYCTTVSMITGHLMNQFKFTGPS------ATVDTACSSSMSAMEMAVTDLMTGRCQFAMVTGCNLLLNP-SYLQQMCFLGMLSAEGQSRVFDADAK--------------------------------------------------------------------GYVRAEGIVSILLTRQA-N---------------LCQR----IYAS-VVDVKTN--CNGYNPD-------G---ITFPSKDCQCALMIEVYK-R-SDIKT-EDLAYMELHS-----------------------------------------------------------------------T-GTPV------G------DPIEVRSVT-EAIC-ST--R------------------------------------------------------------------E-----K-PLLIGSVKAN-MGHSEATAGLASLVKCILAARHGVIPPQRN-FK-----K--PNPNIESFKDGKVIVVN--EPT-ELKD----G-------YIGLNSFG-FGGSNGHVILKPFR----RK--K-K------A---V-A--------KQ----------------------F-------CLVPVTARTDSEKESIM-------------------- 32 ------------------------IAIVGIGCRFP-G-A---DNVTEYWRVLS-NGENHV-KEVP-R--D-RW-NIDA--FYD----PDRNAPGKT-YVRTAGFV-----N-S--ID-EWDHRFYGINDM-EAELIDPQQRIVLDCVHMALEDGGITR--------KDIEG--TQTGVYI---------------------------------------G-SMTDDY--KGHV-MT-----------D----T--T-INSTYSVTGTHNSIISARVSYTYNLSGPA------LTLDTACSSSLVAIDVASQALLTRKCSMAICGGVNILMDP-QLFVALSKAGMLSPSGQCKTFTKEAD--------------------------------------------------------------------GYARGEGCGIVLLKTLK-E--------------A--VKDGNKIWG-TIR-TGTN--QDGHMAT-------P---ITAPSGLQQEQLIKHLYES-Y-RVDK-SRIQVIEAHG-----------------------------------------------------------------------T-GTAI------G------DPTEANALG-THFG-KR--A-DA---------------------------------------------------------------K-----G-AVFIGSVKTN-IGHLEAAAGVAGLIKVLLMMKFDIIVPSLW-YS-KD--N--ENPKVT-LSEHGFVVPT--QCI-HWEM--P-G--T-GKRLACVNSFG-FGGTNAHCIVEEYG----PF--K--------------P------------------TV-SVTK--S--F-L------PCIITISAFDQDTLI----------------------A 33 ------------------------IAIVGIGCKFP-G-A---DDIDEFWQVLV-NGENHV-TDIP-H--E-RW-NNDA--YYS----ENPDDPGKI-YVKKAAFV-----K-N--YD-TWDNKLFGISDI-EGSQMDPQQRYVLECVHMAMEDGGFTR--------KESDG--SKTGVYI---------------------------------------G-VMNDDY--KSFY-EL-----------D----H--D-KDTNYIPTGTNNTIIASRVSYVFNFQGPC------TVVDTACSSSLIAIHLASQGIRFGDCDMAICGGVGSLLSP-AVFIPLCRARMLSPTGQCQTFCDSAD--------------------------------------------------------------------GYVRGEGCGIIILKKLE-Q--------------A--RKDGNRIWA-TIL-TGTN--QDGRMAH-------P---ITAPSGEQQEKLLKDVYSR-Y-GVDP-TTLQYIECHG-----------------------------------------------------------------------T-GTAV------G------DPVEVNALG-HFVS-SH--H---------ETTNQLKPS----E-----QSKNAKKKEMSLNGKSQICKR-----------------------E-KILIGSVKSN-IGHLEAAAGCAAIIKVLLMMKYGKLVPSLH-VK-KDKTN--LNKQIK-FEEYGLDVSV--DLK-DWKP--N-K--D-EMRIGCVNSFG-F------------------------------------------------------------------------------------------------------------------ 34 ------------------------IAIVGIGCRTP-G-A---DNIREFWRLLQ-NGECHI-GDVP-A--D-RW-HATS--YLD----PDLSAPGKA-YVQKGGFL-----R-D--VY-GFDSGLYGINDF-EASQMDPQQCVLLECTTMALQDAGLTS--------THLRS--STTGVYI---------------------------------------G-SMNTDY--AFTF-LG-----------K----N--S-KGNSYTATGVSNTILASRLSYIFDLRGPC------MVLDTACSASLIAVHQGCQAIRSGDCDMAICGGVNCMLLP-DMFTMLSKARMISPTGLCHTFSDKAD--------------------------------------------------------------------GYTRSEGCGIVILKRLQ-D--------------A--IRDGDPIRA-VVY-TGTN--QDGHAVS-------P---MTAPSGEQQKKLLCSIYEK-Y-QLDI-SQLDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEVNALG-SFFT-ER---G----S------------------------------------------------------------L-----H-QRHIGSVKTN-IGHTESAAGVLGLIKVLLMMEYDLIVPSLN-C---Q--T--LNPKIG-LTAHSFVIPQ--KLV-PWTR--P-------HKMAACNSFG-FGGSNSHAVLRSYT----AA--D-D----------S-----SQ-Q----S----------PVH-----K-S------RCIVCFSGNSQRGLKSSL-------------------- 35 ------------------------IVIVGIGCKVP-G-A---DNTEQYWRLLE-NGENHV-IEIP-K--E-RW-NNEA--FYD----PDPHAVGKS-YVRRAGLL-----K-D--PL-AFDNKLFNINDF-EADQMDPQQRLVLECSYMAMEDAGLTR--------DKLTG--SNTGVYV---------------------------------------G-AMNGDY--RGLF-TA-----------K----S--P-IVGNYTVTGISNSIIAARVSFTFDLRGPS------MTVDTACSSALLAIHLGAQALRAGDCDLALCGGTNFLMSP-DVFVHLSKAHMVSPTGQCFAFSDSAD--------------------------------------------------------------------GYTRGEGCGMVFLKRLE-D--------------A--LRDGDKIWA-TVE-TGSN--QDGHSVT-------P---ISAPSGDQQIKLLEHVYRN-A-SIRMLDGIEYIEAHG-----------------------------------------------------------------------T-GTAA------G------DPVEANALG-KFFQ-DK---G----S------------------------------------------------------------I-----R-HRYIGSVKTN-LGHLESAAGTAGLIKVLLMMKHSKIVPTLF-FE-----R--CNPKID-FPSMNLTVPT--KVI-DWPT--H-------TKAACVNSFG-FGGTNCHAFVKMYG----ES----L----L-R---Q-SS---------QV----------ESL-----N-V------PCIVCFSAKHEKSL---K-------------------- 36 ------------------------VAISGISGRLP-E-S--Q-NLAEFRDHLM-NKEDMV-TE---DDR--RW-QV-------------GK-H--G-VPPKNGKLK--------ELRH-FDAGFFGVHPK-QADCMDPQLRMLLEASYEAIIDSGQTL--------ESVRGS--RTGVYV---------------------------------------G-VSSSES--SDAW-TV---D------------P--E-TLVGYTMPGCCRAMFANRISYFFDFKGP------S--------------------------------------------------------------------FAVDTACSSSMICLDQALLNIRMGIIDAAIIGGCNLCLKLTTSLQFTRMGMTAPD-GHCKTFDASGNGYCRSEAVMAMYIQKSP-D--------------C--KR----LYA-TVVHTKSN--CDGYKEQ-------G---ITFPSGDLQKELIKEVYNE-I-GINP-LDVSYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQETNTIV-DVFC-K--G---R----------------------------------------------------------------K----E-PLLIGSTKTN-MGHPEAASGLTSIAKIIIAMEEKIIPPNLH-Y---H--T--PNPEIPGLTDGSLQVVT--ECT-RWNG-----------GLVSMNSFG-FGGANVHAIYRSH--D--KE--L-T------E----PHV--AS-Q-------------------------K------PRLFTCCARTEDGVRAIL-------------------- 37 ------------------------IAIIGIGCRFP-G-A---TCLEEYWDILA-KGENHV-VDIP-P--E-RW-NMDA--FFD----SDVNAVGKS-YATKAGLL-----K-N--FD-HFDNKLFKINET-EAAQMDPQQRQVLECTYMALEDAGITR--------QQIAG--QKVGVYI---------------------------------------G-SMTVDY--GDLI-SN-----------K----S--P-DVTNHTVTGQASSIISNRVSYVYNLTGPS------MTIDTACSSSIVAIHQAGLALRAGDCSIAICGGVNLLIHP-AYFIKLSKAQMLSPTGQCHAFSANAD--------------------------------------------------------------------GYTRGEGCGIVIVKLLS-Q--------------A--LHDGDNIWG-TIV-TGLN--QDGRQVT-------P---ITAPSGKQQQELLKDIYTR-H-GIDP-TQVDYIEAHG-----------------------------------------------------------------------T-GTKR------G------DPVEATALG-TFFE-KY--PR-Q------------------------------------------------------------------------RHIGSVKTN-IGHLEAAAGVAGLIKVLLMMKHNTIVPSLH-FD-KP------NEAID-FDRFNFVVPT--ENT-DWKR--H-------KKVACINSFG-FGGSNSHAVLKSFT----ME--T-----------------------------------------------------------------------S-------------------- 38 -------------------------DILACGVRLP-AGV---ESPGTFWALLD-QDD-QD-S--A-F--SCR---DGL----------------------TAAFLQPQFDH-K--AA-LAAAEESGVEGA-EAAAMDPQHALALKLARDMFQD-----AGEETLKAVQKVR--ERVGVYI---------------------------------------G-AWQGVA---NS---G----------------K--P---SAYHAIGASLSALAARVANAYDLQGPA------VTVNTACSSALVAVNEALKDAKAGRIDFAIVGGVNLFGDE-QLFHHLRRASMLSPSGRCHTFSAEAD--------------------------------------------------------------------GYVRAEGGVLFLLAREA-L--------------E--LPSHGR----ILG-SAVT--QNSRRK--------P---LSSVDPIAQEHAVQFACSD-A-GIKP-SELAVVELHG-----------------------------------------------------------------------T-GTPL------------GDPVEVSALA-RTLR-E----R-----------------------------------------------------------------S-----E-ACWMTAAKMH-VGHLESAAGAVGLLKAMLMCEHGKVPAF-R-ID-G--KG--LNPQVMAAMEGSCLCKP--GQ----PG--V-L--M-ADAMLGVSSFG-FAGSNAHVVMTA------------------------------------------------------------------------------------------------------- 39 -----------------------------CGLRLP-AGV---ASPGAFWSLLE-KDD-QS-S--A-F--RSKL--PGI----------------------TAAFLH--FDQ--------VAAAVDGVEGA-EAAAMDPQHAFALQLAAEMFQDVEATPAGPEILKLLREAR--ERVGVYI---------------------------------------G-AWQEIT---PT---A----------------S--T-GTSAYQTIGTSLSALAARVANAYDLQGPA------MTINTACSSALVAVHEALKDAKIGRIDFAIVGGVNLFGEDLQLFHQLRRAMMLSPSGRCHTFSAEAD--------------------------------------------------------------------GYVRGEGGVLFLLARED-L--------------H--LPSCGR----ILG-SAVT--QNSRRR--------P---LSSVDPFAQEHAIRLACAD-A-RLSP-SELSAVELHG-----------------------------------------------------------------------T-GTPL------------GDPVEVSALA-RTLG-D----S-----------------------------------------------------------------T--------CWMTAAKMH-VGHLESAAGAVGLLKAMLMCQHRRVPAF-K-IG-K------LNPQVMAAMEGSCL-KL--GE----EG--V-L--M-EDAKVGISSFG-FAGSNAHVVITAPR----EG--A-N------R---P-PY--------------------------------------------EARTEE-------------------------- 40 ------------------------IAIIGIGCRFP-G-A---SCLREFWQVLV-NGENHV-VEIT-D--E-RW-NKDA--YYD----KDPRTPGKS-YAPRAGFI-----K-N--YA-HFDFKMFGMNEH-EAAQMDPQQRQVLECTYMALEDAGITR--------QQIAG--QKVGVFL---------------------------------------G-CMNNDF--TQLA-NK-----------Y----P--H-LVDNFTVTGTGNSIVSNRVSYAFDLRGPS------MTIDTACSSSLVAIHQAGLAMKEGDCSMAICGGVNLLLSG-GVFVPLSKAQMLSPTGQCHAFSANAD--------------------------------------------------------------------GYTRGEGCGIVIIKPFK-Q--------------A--LEDGDNIWG-TLV-TGLN--QDGHVAK-------P---LTAPSGEQQAQLIQDVYTK-H-GIDP-ASIDYIEAHG-----------------------------------------------------------------------T-GTKI------G------DPVEVKAFG-DFFL-QQ--QQ-S--K------------------------------------------------------------R--------RYIGSVKTN-IGHLEAAAGVAGLIKVLLMMNHSTIVPSLH-FD-MP------NEEID-FDKFQFDVPT--KTV-QWLP--D-------QKVACLNSFG-FGGANSHALVKSIS----NR--Q-I------N---S-T----Y-S-----------------C-----T-K------PIVICFSGSNHQT----L-------------------- 41 ------------------------IAIVGVGCRAP-G-A---DNLDGYWRVLK-NGECHM-GDVP-P--S-RW-NAAA--FLD----PDPNALCKA-YVQKGGFI-----T-D--VE-SFDNALYGINDF-EAVQMDPQQFLLLDCAVMAMEDGGLTR--------QQMSG--SSTGVFI---------------------------------------G-AMNKDY--SAAY-FG-----------Q----T--S-KVNTYTGTGISNAILASRVSYVFDLRGPC------LVVDTACSASLVALHQACLAIRSGDCDMAFCGGVNCILTP-DMYIQLCKARMISPTGLCHTFSEDAD--------------------------------------------------------------------GYARGEGCGIVILKRLK-D--------------A--LRDGNKVWA-TIH-TGTN--QDGRSVT-------P---MTAPSGEQQKKLLHAIYSK-C-QVDI-SLLDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEVNALG-SFFK-EH---G-G--Q------------------------------------------------------------P-----R-SRYIGSVKTN-IGHTESAAGVLSLIKILLMMKHNTIVPSLH-C---Q--K--INPKIN-LQSWQFIIPK--ELV-PWKS--P-------NKLAACNSFG-FGGSNAHVLVSSCL----ST--Q-S----------A------Q-E-TDSS----------YSR-----N-------KFSIVCFSGKTQKGL---K-------------------- 42 ------------------------VVISGISGRFP-E-S---ENMAEFRDHLM-NNEDMV-TA---DDR--RW-KQGL--------------H--G-IPARSGKIK--------YVNY-FDARFFGVSPA-AADCMDPQLRMLVEATYEAFVDAGQNM--------DSVRGT--KCGVFT---------------------------------------A-ANRSDA--GDAW-SA---Y------------S--D-ATLRYSMPGCCRAMFANRLSFSFDLKGA------S--------------------------------------------------------------------YSVNSACAAGLVCLDIAVHQIRMGVIDSAIIAGTNLDLKPTSVLQFVRMGFTSPD-GACKSFDATADGMARSDAVVAIFLQKAE-D--------------A--KR----IYS-TVVHCGLN--SDGAREK-------G---ALKPVGEVQKDLMQRVVDE-S-GINP-SEVAYVEAHG-----------------------------------------------------------------------F-GSLE------------MDKIEGNNVV-DVFC-K--G---R----------------------------------------------------------------K----G-PLLIGSVKSN-VGHSEDASTLTSLAKIIIAMEEGVIPANLH-Y---K--T--PNPGIPGLVDGRLKVVT--ENT-PWKG-----------GLVAVNSYS-WWGTNGTAILRSH--D--KE--L-K------E----PHF--AS-K-------------------------K------PRLFTCCARTEEGVKALL-------------------- 43 ------------------------IAVVGIGCRFP-GRV---NSPADMWDVLV-EGRDCL-EPIP-D----RW-NVDA--YYS----PDPHSLGTH-VNKKGGFVR------D--VD-CFDNAFFKIAPK-EAVLMDPQQRQLLEVTHEAFEDAGVVP--------SRLGG---KCGVYV---------------------------------------G-IGLMDY--ALMN-SS---E------------P--R-KYNAYSHTGMAHSVAANRISFAFNLQGPS------LATDTACASSMTALHLACSGLWNKECEASIVAGSNILLMP-EITCGFSALSVLSPESQSRPFDADAK--------------------------------------------------------------------GYVRSEGFGALLLKPLE-T--------------A--LRDGDNIYC-TVVGTGIA--ANGLTP--------S---ITMPSKDAQAQLMTSVYKH-F-HLSQ-EELLYVEAHG-----------------------------------------------------------------------T-GTPV------------GDPIEAEAIG-TALA-AG--R------------------------------------------------------------------D-----E-PLRIGSAKSN-FGHLECAAGLISLVKASLMLKYRKLVPSIN-FR-Q------PATPL--FSEWNVQVQT--AVE-DFPE--G------Q-HTLAVNNYG-FGGALAHAVLKEAP----AA--A-P------K---K-TG--SA-G-WT---FGAQ-EA----N-----G-------RPLVVPLSARSQEALQALV-------------------- 44 ------------------------IVISGISGRFP-E-S--A-NMEEFKKNLM-EGIDMV-TD---DER--TW-PPVL--------------N--G-LPARTGKIK--------DLSK-FDASFFGVHAK-QAEVMDPQLRMLLEATYEALIDAGLNP--------NEMRGS--RTGVFI---------------------------------------G-ASASES--GEYW-TL---E------------S--E-RVNGYGLTGCARAMFPNRISFTFDFKGP------S--------------------------------------------------------------------FAIDTACSSSMLAFHQAVTAMRNGECDAAIVGGVNLLLKPNESLQFHRLSMLSPD-GACKAFDASGNGYVRAEACVVTLLQKVS-N--------------A--KR----VYA-TVINTGTN--TDGNKEQ-------G---ITFPSGKVQKDLILSVFEK-A-GMNP-AEVVYIEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNSIA-EVFC-K--G---R---------------------------------------------------------------NH----G-PLLIGSVKSN-MGHSEPASGLCSLAKVLVAMETNTIPANLH-F---K--Q--PNQEIPALSDGRLQVVD--KNW-DWNG-----------GIAAINSFG-FGGANVHLILRSN--P--KP--K-S-----------TPV--KD-N-------------------------I------PRLVAVSGRTYEAVDSFL-------------------- 45 ------------------------VVISGLSARLP-E-S--A-NIDEFREQLF-AGVDLI-TD---DER--RW-PSGL--------------H--G-LPTRTGKIK--------ELDK-FDATFFGVHAK-QAHVMDPQLRMLLELTHEAIIDAGVNP--------ASVRGS--RTGVFI---------------------------------------G-VSASES--DEFW-TM---D------------P--E-QVNGYGLTGCCRAMFPNRISYTFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLFALQQAVSAMRTGQCEAAIVGGVNLLLKPTCSLQFHRLGMLSPQ-GMCKAFDASGNGYVRSEAAVVIYLQKAS-V--------------S--KR----IYA-TIVNARTN--TDGNKEQ-------G---ITFPSGAMQKKLILETYAE-A-GVSP-SEVVYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNSIA-DVFC-K--G---R---------------------------------------------------------------NT------PLLIGSVKSN-MGHSEPASGLCSIAKTLIAMESGVIPANLH-F---K--N--PNKDIPALHDGRLKVVS--ENT-SFPG-----------GYVAINSFG-FGGANAHIILKSN--P--KP--K-P-----LS----PPL--LT---------------------------N------PTVVAVSGRTEEAVKEFL-------------------- 46 ------------------------VAISGISGRLP-E-S--N-NIQEFRDHLM-KGDDMV-TA---DDR--RW-PV-------------GL-H--G-LPPRCGKVP--------ELTK-FDAGFFGVHPK-QADCMDPQLRMLLEASYEAIIDAGQSM--------ESVRGS--RTGVYI---------------------------------------G-VSLSDA--SDGW-TM---E------------T--E-GMVGYTMPGCCRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALMGIRTGIIDSALVGGSNLCLKPNTSLQFTRMNMTSPD-GACKTFDASANGYCRSEAIMAIFLQKVP-D--------------C--KR----IYA-TVVHTKSN--CDGYKEQ-------G---ITFPSGELQKCLINEVYDE-I-GINP-ADIAYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINSIV-DVFC-K--D---R----------------------------------------------------------------T----A-PLLIGSTKTN-MGHPEAASGLTSIAKIIISMEEGVIPPNLH-Y---K--N--PNPEIPGLTDGSLQVVS--ECT-KWGG-----------GLVAMNSFG-FGGANVHAIYKSN--Q--KE--L-K------E----PHP--AS-Q-------------------------K------PRLFTYAGRTEAGVRAVL-------------------- 47 ------------------------IAISGISGRFP-E-S--D-NMDEFQQNLM-EGRDMV-TD---DDR--RW-TPGI--------------Y--G-LPTRTGKLK--------NISN-FDANFFGISGK-QAETFDPSIAFLLELTHEAIVDSGTNP--------MDLRGS--NTGVFI---------------------------------------A-VTCNDP--LEYH-SL---N------------S--E-PIG-YAMTGCHKSMCSNRISYCFDLRGP------S--------------------------------------------------------------------MTIETACSSSFNALYLAVEALKKGDCDAAIVGGTNLLLNPQYSRMFFKLNMLSVD-GICKSFDDSCNGYVRSEAAVVIFLQKVS-A--------------A--KR----VYA-TVVNIEIN--TDGYKED-------G---PTYPSRIMQSALMTKVIEK-S-KINP-LDVAYVEAHC-----------------------------------------------------------------------T-GTKA------------GDVQEINAIA-DIYC-S--GR--T----------------------------------------------------------------S----G-PLLIGSVKSN-MGHGEPASGLCGIAKVVIAMETGIIPGNLH-Y---H--N--PNKNIPALSNGKLKVVD--KNT-KWNG-----------GLVVINSFG-FGGSNVNLILRSN--P--K---P-K------S----IRY--TD-N-------------------------K------PVLVQVSGRTE--------------------------- 48 ------------------------VGISGMSGRLP-E-S---DNMAEFKDNLY-KKYDMT-SD---DDR--RW-KVDS--------------Q--G-TPLRSGKVK--------EIRQ-FDADFFGISAR-EANCMDPMLRMLLEVSYEAIVDAGQSM--------ESLRGT--RTGVYL---------------------------------------G-VSLTET--QNAW-AA---Q------------T--E-NVSPVLLSSCSKSVFAYHVSNFFDLRGP------A--------------------------------------------------------------------YGVDTGCSSSFICLDQALQAIRAGVVDAALVGGMNMCLQPIVTIMFGRMQMLSDE-GRCKSFDASGDGFSRSEGVMAILLQKAK-D--------------C--KR----IYG-TLIHAKSN--NDGYTPE-------G---VTFPSGEAQGRLITEVYQD-V-GIDP-REVSYVEAHG-----------------------------------------------------------------------T-GTPT------------GDPQEVNAIT-RIFC-K--D---R----------------------------------------------------------------K----D-PLLLGSTKSN-MGHAEMLSGLASIGKILFAMDEGIIPPNLH-Y---Q--N--PNLAIPGLVDGRIKVVT--EPT-PWKG-----------GLACVNNFG-FGGANVHAVLRSF--D--KV--Q-T------K----PHV--AS-R-------------------------S------QRLFTYCGRTEEGVKAVL-------------------- 49 ------------------------IAIVGIGCKVP-G-A---ENIRDFWRVLL-HGENHI-VEIP-P--S-RW-NADA--FYD----ADPMAPGKT-YVKRAGLV-----S-E--SD-EFDNKLFGINDF-EAAQMDPQQRFVLDCTLMALEDAGLTR--------AQISG--SNTGVYL---------------------------------------G-AMNADY--RGLF-TA-----------N----S--S-NVGNYTVTGISNSIIAARLSYVFDLRGPS------LVLDTACSSSLIGIHLGCQAIRAGDCSMAIAGGTNYLTLP-DVFVHLSKAGMISPTGQCHSFSSKAD--------------------------------------------------------------------GYTRGEGCGIVILKKLR-D--------------A--ERDGDNIWA-TIY-TGSN--QDGHSVA-------P---ITAPSGLQQAGLLDSVIKK-M-GLDM-NRIDYIEAHG-----------------------------------------------------------------------T-GTNA------G------DPVEANTLG-EFFK-TR---S----T------------------------------------------------------------P-----R-QRYMGSVKTN-IGHLESAAGVIGVIKVLLMMKHGKIVPSLH-FD-----E--ANAKIN-FEDLMLTVPT--QPV-EWDN--P-------DKVCCCNSFG-FGGSNSHAVVCHYK----QP--G-N------T---S-QD---------IISA--------DKT-----R-R------PCIVCFSACSEKSLRAIM-------------------- 50 ------------------------IAIVGVGCITP-G-A---DNLDEFWRLLV-NGENHV-IDIP-P--E-RW-NVNA--YYS----PDSMSPGKT-YVKRAGLI-----R-A--PD-EWDNRLFGINDF-EANQTDPQQRLVLDCTHMAMENAGLTK--------QQLQG--TNTGVYV---------------------------------------G-SMNSDY--RGLF-TA-----------S----S--T-IVGNYTATGISNSIISARVSYVYDLRGPS------MTIDTACSSALVSVHLGAQAIRAGDCEIAICGGTNYLTLP-DVFVHLSKAHMLSPTGQCHAFSDKAD--------------------------------------------------------------------GYTRGEGCGMVILKKLS-D--------------A--IRDGDNIWA-TVL-TGSN--QDGRTVS-------P---MTAPAMAQQIKLMEHMYAH-Q-DVDI-DRLDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPIEANAVG-NFFK-DH---S-T--V------------------------------------------------------------S-----R-TRYIGTVKSN-MGHLESAAGAVGIIKVLLMMKHSKIVPSLH-YT-KD--H--PNPRID-FDELQLIVPE--EVI-DWPR--E-------HKVACASSFG-FGGTNSHAILMEYM----SP--K-N------D---I-MD---------VS----------LMV-----K-K------PCIVCFSANSEKSLQGSL-------------------- 51 ------------------------IAIVGIGCKVP-G-A---DNIRDFWRVLL-HGENHV-VEIP-P--S-RW-NADA--FYD----PDPMAHGKT-YVKRAGLV-----S-G--SD-EFDNKLYGINDF-ESAQMDPQQRFVLDCTLMALEDAGLTR--------AQIAG--SNTGVFL---------------------------------------G-AMNSDY--RGLF-TA-----------H----S--S-NVGNYTVTGISNSIISARVSYVFDLRGPS------LVLDTACSSSLIGIHLGCQAIRSGDCDMAIAGGTNYLTLP-DVFVHLSKARMISPTGQCHSFSSKAD--------------------------------------------------------------------GYTRGEGCGIVILKRLK-D--------------A--IRDGDNIWA-TVF-TGSN--QDGHSVS-------P---ITAPSGFQQKCLLESVFDR-I-GLDL-SRVDYIEAHG-----------------------------------------------------------------------T-GTNA------G------DPVEANSLG-EYFK-SR--------A------------------------------------------------------------P-----K-ERYVGSVKTN-IGHLESAAGVVGIIKVLLMMKHSKIVPSLH-CE-----E--ANPKID-FPDLMLTVPG--KPV-DWNN--P-------DKVSCCNSFG-FGGSNSHAVLEYYK----PA--D-S------D---S-KE---------LMPA--------SST-----R-K------PCIVCFSAYSEKSLRGIM-------------------- 52 ------------------------IAVVGVGGRFP-G-A---KDVDQFWRLLL-NKENHV-KDI-PP--D-RW-NNDA--FYD----ANPDVPGKT-YVKKAGLL-----D-D--HD-VFDNRLFGINDL-EAERMDPQQHYVLECTHMALENAGITR--------AKIAG--SRTGVYI---------------------------------------G-AMNQDC--NAAA-QY-----------D----G-CV-SCNSYSVTGPTGSILAARVSYVFDLRGPS------MVVDTACSSSLVALHLAIQGILSGDCDMAICGGVSSILLP-NFFIVLSRARMLSPSGQCQAFSQTAD--------------------------------------------------------------------GYARGEGCGVVILKRLG-QAVR----------------DGDHIWG-VVLGTLCN--QDGRTAT-------P---LTSPSGAQQVNLLRDVYSK-F-KVNP-RDVTYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEVNALG-QFFG-ST--D------------------------------------------------------------------R-----P-PLPIGSVKTN-IGHLEPAAGMAGLIKVLLMIRHKQYVPTVL-FS-----E--LNPQLD-FAGYGFHVCR--DVT-EWKV--S-P--G-HARIACVNSFG-YGGTNSHAIVQEYV----AN--S------A-E------------S---------R-SL-AA-------E--------------P------------------------------- 53 ------------------------VAIVGVGCRFP-G-G---DGLDGFWDVLI-QGQDCL-TDIP-D--E-RW-CSKA--YYD----PDGDKRGKS-YVKRAGFV-----T-D--HD-AWDNRLFGVSDM-EAASMDPQQRLAVECSYRAMENAGITR--------QQLKG--SNTGVYI---------------------------------------G-VMSVDY--QSMY-SL-----------Q----S----ETTNYTLTGVSGSNVAARVSYVFDLRGNS------LVVNTACSSSMEAIHLGCQALRAGDVDLALCGGVNSLLEP-GTFIQLSRARMASPTSSSKAFSANAD--------------------------------------------------------------------GYARGEGCGMLLLKRYS-E--------------A--VAAGDRIWA-VVH-TGTN--QDGRTVS-------P---MTAPSWKQQKQLFHDVFRR-S-GLDP-TQVEYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPVEARSLG-EFFL-EV--D-----GARQTGRTDGDQT----------------------------------------VDK-AG--G-----R-ERWMGSVKTN-IGHLESAAGVAGIIKVLLMMQHGKMVPSLH-FD-----V--PNPRID-FQGYRLNVVT--QPR-DWNQ---------PMKMACVNSFS-FGGTNGHALLTSVP----AV--K-A------S---E-DQ------E-E--SQP-------------------------YIVCFTGASQES----L-------------------- 54 ------------------------LAVIGIGCRFP-G-A---TCLEEFWDVLR-NGEDHV-VDIP-S--E-RW-NMDA--YFD----ADINAVGKS-YASKAGLI-----K-D--FD-HFDNKLFKINEV-EAAQMDPQQRQVLECTYMALENAGITR--------QQIAG--QKVGVYV---------------------------------------G-SMTTDY--GDLV-CY-----------N----S--P-DISNHTVTGQASSILSNRVSYVYNLTGPS------MTIDTACSSSLVALHQAGLALRAGDCSMAICGGVNLLIHP-AYFIKLSKAQMLSPTGRCRAFSANAD--------------------------------------------------------------------GYTRGEGCGIVIVKLFS-Q--------------A--LHDGDNIWG-TIV-TGLN--QDGRQVT-------P---ITAPSGKQQQELLNEIYTR-H-GIDP-TEVDYIEAHG-----------------------------------------------------------------------T-GTKR------G------DPVEGTALG-TFFE-KY--PH-Q------------------------------------------------------------------------RYMGSVKTN-IGHLEGAAGVAGLIKVLLMMKHNTIVPSLH-FD-RP------NEAID-FGRFQFVVPT--ENV-DWNT--H-------RKIACVNSFG-FGGSNSHAVIKSFT----IA--------------------------------------------------------------------------T-------------------- 55 ------------------------VAIVGIGCRFP-G-A---DNVDEFWQVLK-NGENHV-IEVP-E--N-RW-NLDA--FYD----EDPTTPGKT-NVRRAGFV-----K-E--FD-YWDYKFFGINEF-ESLRMDPQHKFILDSTYMALESAGITR--------KEIKG--SNTGVYV---------------------------------------G-IMNSDY--STNF-AE-----------S----F--G-DFDNHTITGTNNSIVSSRVNYTFDLHGPS------MTIDTACSSSLMAIHHAHQAIITGECDMCIAGGVNALLKP-DNFIQLSKAGMVSPTGQCQAFSENAD--------------------------------------------------------------------GYARGEGSGIVILKSYE-K--------------A--IEDNDPIWA-TIS-TASN--HDGHTVS-------P---ITTPSMQQQIELLNIVFKR-F-DVDP-QSIDYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPVEVKALG-TFFQ-----------------------------------------------------------------TD-EN--S-----T-PKTIGSVKTN-IGHLESAAGVAGLIKVILMHHHREIVPSLH-FE-----K--PSPEVP-LEEYRFTVPV--KPE-VWPE--TE---R-DFLRSSVNSFS-FGGSNCHAIVTTPK----NR--C-V------R---I-FA--G-----H--DIP-------------------------KVVCISAIEPPALKR-I-------------------- 56 ------------------------VAIVGIGAITP-G-A---ENIREFWRLLK-NGENHI-TDVP-A--S-RW-NADT--FYD----SDPMKPGKT-YVSKAGFV-----H-N--AE-KFDNAFFGVNEY-EAASMDPQQSLVLECTYRALENGGIT----------HISG--TNTGVFI---------------------------------------G-AMTSDH--ASFY-PA-----------G----S--P-EVDSYTATGVSSSMLAARISYVYNLLGPS------MVIDTACSSSLVAIHQGIQAIKNGDCDMAICGGVNYIGAP-AMFVQLSKAKMLSPTGRSRAFSADAD--------------------------------------------------------------------GYVRGEGCGIVVLKRLK-D--------------A--KDNNDHIWA-TVV-SGVN--QDGHTVT-------P---VTAPSGTQQEKLMRDIYTK-Y-SVDV-SRLDYIEAHG-----------------------------------------------------------------------T-GTRA------G------DPVEVNALG-NFLK-TM---S----E------------------------------------------------------------P-----R-TRYIGSVKTN-IGHLEAAAGVIGVIKVLLMMKHDTIVPSLH-C---Q--D--VNVDID-LQTLRLDIPQ--TCI-SWKG--E-------DKMACCNSFG-FGGTNSHLVLR-------------------------------------------------------------------------------------------------------- 57 ------------------------VAIIGIACKTP-G-A---ENIRDFWRILL-NGENHI-TEVP-P--S-RW-NGEV--FYD----EDPTKQGRT-NVRRAGFV-----K-C--IE-DFDNGFFGINDY-EAFSMDPQQRFVLECTHMALEDGGLTK--------AKISG--TNTGVFI---------------------------------------G-AMNSDH--SCLL-NA-----------G----S----QTDRYGVTGATNAILAARVSYVYNLQGPC------MVLDTACSSALVCIHAGAQAIRNGECDMAVCGGTNYMGTP-GLFIQLSKSAMISPEGLSKAFSAKAD--------------------------------------------------------------------GYARAEGCGIVVLKRLK-D--------------A--IRDNDKIWA-TVV-SGIN--QDGHTVT-------P---MTAPSGKQQVELMKRVFKK-Y-KIDA-YKVDYIEAHG-----------------------------------------------------------------------A-GTQA------G------DPVEANAVG-TFLK-EA---S----D------------------------------------------------------------P-----R-PRYIGSVKTN-VGHLESASGAIGVIKVLLMMKNDLIVPSLL-W---G--D--VNPQIN-LNQLGLIIPR--SPV-KWNK--E-------DKMACCNSFG-FGGTNAHAVFQTHQ----SC--H-P----------K--K--IT-T-N---------------R-----H-E------TTIICFSGKSILSLKQSL-------------------- 58 ------------------------IVVIGIGCRTP-G-A---DNTQEFWELLK-RGECMI-TDVP-P--G-RW-NAAA--YLDT--DSSTRAFGKA-YVQKGGFV-----K-D--IY-GFDNVLYDIKEL-EAIQMDPQQRMLLDCTYMAMQDAGITR--------TDIWQ--TNTGVFV---------------------------------------G-CMNDDH--ATSY-AA-----------S----T--S-KTSSVSATGCATSVLAGRLSYVFNLLGPS------MMIDTACSSSLMAFHLACQAIRAGECDMAICGGVNCMILP-EMYVQLCKAGMLSPTGLCHTFSDQAD--------------------------------------------------------------------GYTRGEGCGVVILRWLK-D--------------A--LRDGNNILA-TVVGTGTN--QDGRTATTDDGRTAP---ISAPSGSQQVKLLTSVYRK-A-GVDV-SRLDYIEAHG-----------------------------------------------------------------------T-GTPT------G------DPVEVKALG-EFLR-TE---G----G------------------------------------------------------------P-----R-DRYIGSLKTN-IGHTESAAGILSVIKLVLMMKHNMIVPSLH-C---H--V--VNPKID-LAELRFSIPK--QTI-PWSN--P-------LKLVGCNGFG-VGGSNCHAILSSCN-----K--H-T----------D------T-V-V--------------AS-----R-T------SYVVCFSAKTERSLK--A-------------------- 59 ------------------------VAIIGVGCKFP-G-A---DNLEEFWSLLE-NGENHV-TEIP-E--T-RW-FHES--VYD----PDFNTPAKT-HARKAGLL-----K-D--HL-AFDNKLFNIKDV-EADIMDPQQRYVLECCHRAQEDAGLTR--------DQLSG--SNTCVFI---------------------------------------G-AMNTDY--RSQF-NS-----------T----S--F-ETDNYSVTGMAGSIIANRVSYIYDLRGPS------VTIDTACSSSLVAIDMGLHYLRAGTCDMAICGGVNSILTA-DLFIHLSKARMVSAKGQCFAFSDQVD--------------------------------------------------------------------GYTRGEGCGVVILKRLQ-D--------------A--KRDKNNIWA-TIE-TGCN--QDGGTVA-------P---ISKPSEEQQIKLLQAVWDR-S-RADP-GDLFYIEAHG-----------------------------------------------------------------------T-GTPV------G------DVVEVNALG-TFLQ-GT--H-----T------------------------------------------------------------G-----NV-RYIGSVKTN-IGHLESAAGVAGLIKVLLMMKHSMIVPSLH-FQ-RP------NPNID-FHGFHLKVAT--EVI-SWPE--P-------RKVASVTSCG-FGGTNSYAIIESQG----QP--G-R------A---K-P----D-M-P-----------------------S------ENIVCFSAMNLESL---K-------------------- 60 ------------------------VAIIGVGCRFP-G-A---ENLDEFWRVLS-NGENHV-VEIP-A--N-RW-NVDA--FYN----KDPSTPGKT-NVRRAGFL-----Q-S--HD-EWDYKVYGINEF-EALRMDPQHKFVLDSTFMALENAGITK--------TQLNG--SNTGVYI---------------------------------------G-MMNSDY--NSIY-SA-----------S----L--D-DFDNFTVTGTSNSIVASRVSYVFNLQGPS------IMIDTACSSSLIAIHQAHQAIKSGECDMAVAGGVNALLRP-DVFIQLSKAGMVSPTGQCQAFSEKAD--------------------------------------------------------------------GYARGEGCGIVILKGLE-Q--------------A--LRDNDPIWA-TIS-TASN--HDGRSVT-------P---ITTPSIGQQIQLLDLVFKR-H-NIDP-DTVDYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPVEVTALG-TFFN-----------------------------------------------------------------KT-NR--E-----Q-QRFIGSVKTN-IGHLESAAGVAGLIKVLLMQKHQTIVASLH-FE-----K--PGENVH-LNKFNFRVPI--KTQ-TWPE--NN---R-TILRSSLNSFS-FGGSNCHAVVTSDK----AR--S-E------G---E-EQ--GL-KDDN--QQY-------------------------KLVCLSAHDPSSLQK-I-------------------- 61 ------------------------IAVVGMGCNFP-G-G---EGLENFWKVLL-EGQNCV-VDIP-S--E-RF-DTSF--WSD----ADATKPGKT-QTTRAALI-----D-G--FN-EFDHKFFGISEA-EADVMDPQQKLLLQCSYRALEDAGTSI--------ESISG--SRTGVYV---------------------------------------G-LMNRDY--EMLR-NN-----------N----P--N-TISHYNATGTATSVAANRISFTFNLTGPS------FAIDSACSSSLVALHVACQAMRLGDCEMALCGGVNCIIEP-RVFVALSKAKMTSPEGTSKPFSIRAD--------------------------------------------------------------------GYGRGEGCGVLLLKPLR-S--------------A--KRDRNKIWG-IIRKTAIN--QDGRSVT-------P---ITKPSKVQQEELLRGIYSD------I-ADVQYIEAHG-----------------------------------------------------------------------T-GTPA------G------DTTEAGSIS-DAIA-----------------------------------------------------------------EA-RAPGS-----K-TLMVGSVKGN-IGHTESAAGVAGVIKVLLMMKHETIVPSVF-YS-----D--DSAGVD-MRALKLRVPI--KAE-KWEA--AG------P--------------------------------------------------------------------------------------------------------H-------------------- 62 ------------------------VVIAGIAGKLP-E-S--E-NLQEFWENLL-NGVDMV-TE---DDR--RW-KPG-------------M-Y--G-LPKRNGKLK--------DISK-FDASFFGVHPK-QAHTMDPQLRLLLEVSYEAILDGGINP--------ATLRGT--DTGVWV---------------------------------------G-ASGSEA--AEAF-SQ---D------------P--E-QLLGYSMTGCQRAMFANRISYFFDFKGP------S--------------------------------------------------------------------LTIDTACSSSLMALENAYKAIRNGQCSAAVVGGVNLLLKPHTSVQFMKLGMLSPD-GASKAFDASGNGYCRSEAVVVVLLTKKS-M--------------A--KR----IYA-TIVNAGSN--TDGFKEQ-------G---VTFPSGDMQRQLVSSLHRE-C-GIKP-GDIEYVETHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNGIA-DVFC-Q--C---E----------------------------------------------------------------R----E-PLLIGSTKSN-MGHPEPASGLAALAKVVLSLEHGLWAPNLH-F---S--D--PNPDIPALLNGSLKVVC--EPT-PTKG-----------GLVSINSFG-FGGANVHV----------------------------------------------------------------------------------------------------------- 63 ------------------------VVIAGIAGKLP-E-S--E-NLQEFWENLL-NGVDMV-TE---DDR--RW-KPG-------------I-Y--G-LPKRNGKLK--------DIKK-FDASFFGVHPK-QAHTMDPQLRLLLEVSYEAILDGGINP--------TALRGT--DTGVWV---------------------------------------G-ASGSEA--AEAL-SQ---D------------P--E-ELLGYSMTGCQRAMLANRISYFYDFTGP------S--------------------------------------------------------------------LTIDTACSSSLMALENAYKAIRHGQCSAALVGGVNILLKPNTSVQFMKLGMLSPD-GACKAFDVSGNGYCRSEAVVVVLLTKKS-M--------------A--KR----VYA-TIVNAGSN--TDGFKEQ-------G---VTFPSGEMQQQLVGSLYRE-C-GIKP-GDVEYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNGIV-NVFC-Q--C---E----------------------------------------------------------------R----E-PLLIGSTKSN-MGHPEPASGLAALAKVILSLEHGLWAPNLH-F---N--D--PNPDIPALHDGSLKVVC--KPT-PVKG-----------GLVSINSFG-FGGSNAHV----------------------------------------------------------------------------------------------------------- 64 ------------------------IAICGISGRYP-E-S---ANVGELTHNLL-NKINMI-TV---DNR--RW-EPG-------------Y-F--G-TPEVMGKVK--------NITE-FDAEFFGVHSK-SANTMDPMLRIMLEVAYEAIIDAGESL--------ESMRAS--KTGVYI---------------------------------------A-VSVSEC--EVAW-MR---E------------W--S-EDNAYMVQGCPHSMFPNWISFFFDLRGP--------------------------------------------------------------------------STAYNTACSSGLVALDAAERHLRMGIIDNAIVGGCNFLYRPSTSRLFMSMNFLGST--ACRAFDETGDGFVRSEVASVMLLKKVD-T--------------A--KR----VYC-TLLGSMLN--NDGFQTN-------G---ILYPNSLAQEQLMADIYPS-L-NVDP-KDLKYFECHG-----------------------------------------------------------------------T-GTQA------------GDPNETRAIC-SVIC-K--H---R----------------------------------------------------------------T----E-PLLIGSIKSN-LGHGETASGSAGLSKLVVIMHSRQIPANLH-F---N--T--PNPKIPGLFDGRLKVVT--ETT-PFD-----------GGLVAINSFG-MGGTNAHAIFKSF------------------------------------------------------------------------------------------------------ 65 ------------------------IAICGISGRYP-E-S---ANVGELTHNLL-NKINMI-TV---DNR--RW-EPG-------------Y-F--G-TPEVMGKVK--------NITE-FDAEFFGVHSK-SANTMDPMLRIMLEVAYEAIIDAGESL--------ESMRAS--KTGVYI---------------------------------------A-VSVSEC--EVAW-MR---E------------W--S-EDNAYMVQGCPHSMFPNWISFFFDLRGP--------------------------------------------------------------------------STAYNTACSSGLVALDAAERHLRMGIIDNAIVGGCNFLYRPSTSRLFMSMNFLGST--ACRAFDETGDGFVRSEVASVMLLKKVD-T--------------A--KR----VYC-TLLGSMLN--NDGFQTN-------G---ILYPNSLAQEQLMADIYPS-L-NVDP-KDLKYFECHG-----------------------------------------------------------------------T-GTQA------------GDPNETRAIC-SVIC-K--H---R----------------------------------------------------------------T----E-PLLIGSIKSN-LGHGETASGSAGLSKLVVIMHSRQIPANLH-F---N--T--PNPKIPGLFDGRLKVVT--ETM-PFD-----------GGLVAINSFG-MGGTNAHAIFKSF------------------------------------------------------------------------------------------------------ 66 ------------------------IAICGISGRYP-E-S---ANVGELTHNLL-NKINMI-TV---DNR--RW-EPG-------------Y-F--G-TPEVMGKVK--------NITE-FDAEFFGVHSK-SANTMDPMLRIMLEVAYEAIIDAGESL--------ESMRAS--KTGVYI---------------------------------------A-VSVSEC--EVAW-MR---E------------W--S-EDNAYMVQGCPHSMFPTWISFFFDLRGP--------------------------------------------------------------------------STAYNTACSSGLVALDAAERHLRMGIIDNAIVGGCNFLYRPSTSRLFMSMNFLGST--ACRAFDETGDGFVRSEVASVMLLKKVD-T--------------A--KR----VYC-TLLGSMLN--NDGFQTN-------G---ILYPNSLAQEQLMADIYPS-L-NVDP-KDLKYFECHG-----------------------------------------------------------------------T-GTQA------------GDPNETRAIC-SVIC-K--H---R----------------------------------------------------------------T----E-PLLIGSIKSN-LGHGETASGSAGLSKLVVIMHSRQIPANLH-F---N--T--PNPKIPGLFDGRLKVVT--ETM-PFD-----------GGLVAINSFG-MGGTNAHAIFKSF------------------------------------------------------------------------------------------------------ 67 ------------------------ICITGMSGRVGQ-A----RTLEDFKDLLW-QKKDGF-T--E-E--YSRF-DCD---KF-------------G-TQKRHAYIN--------DIDK-FDSKFFDIDPK-NANFLDPNIRLGMEAVYEAIIDAGYSA--------EELRGT--NTGVYV----------------------------------------SVVAYDA--TYFW-FK---K------------SIED-FGEGS--MGSHNSFRASQVAHHFDLRGPN------SVVDAACSGYLAAVETGMKDIRLGHCDRAIILAVQLHTNP-MGENLFLSIGAAGPNGICYAFDERAE--------------------------------------------------------------------GLARGEAIGCMFLQKEE-D----------------SRR----VWSK-LVHSYQS--ADGNSGD---------FDFNRPSAVGQMENMNECYRQ-A-NIDP-QTVGFVECHG-----------------------------------------------------------------------T-GTIA------------GDGTEGDAMS-KVFL-GD-R---R----------------------------------------------------------------K----T-PLVIGSVKTY-IGHGEGAAGFNAMVKCVMGLNEGVILPNIN-FE-----R--PNPSIPALIDGRMKVVT--EVT-PYDG--D---------IVGINGFG-LGGTDSHVILQK------------------------------------------------------------------------------------------------------- 68 ------------------------ICITGISGRVGQ-A----NNLDEFKDFLW-NKKHAF-T--D-K--FLRF-DLD---KY-------------N-TQKWFAYIN--------DAEK-FDPEFFGIEAK-KANYLDPNIRLSIEAAYEAIVDAGYSM--------EEVRGT--KTGVYV----------------------------------------PCVGYDA--SNYW-SG---K------------GVEE-FGEGS--LGVHNSFRAHRISYEMDLRGPS------MAIDTACSGYMAAIECALKDIRLGNCDQAIVAGSQLHCNP-IAAMLFLDIKAAGPNCICYAFDERAE--------------------------------------------------------------------GMSRGEAIGTLFIQKEC-D----------------ARR----IHTK-VAHAYQS--CDGNSGD---------FDFNHPSVEGQMATIATCYRQ-A-GVDP-HKINFVECHG-----------------------------------------------------------------------T-GTVA------------GDSTEVNAID-NIFC-GE-R---R----------------------------------------------------------------T----E-PLMIGSVKTN-MGHAEAVAGFNAIAKCIISFYESTIPPNIN-FE-----K--PNKSIPGLLDGRLKVPV--ELT-PWNG--T---------MCGVSGFG-LGGTSSHLILKK------------------------------------------------------------------------------------------------------- 69 ------------------------ICITGMSGRVGQ-C----KDLDEFKEMLW-NKKDAF-T--D-K--PMRF-NTD---KY-------------N-KQKEHAYME--------DTES-FDSDYFGIAPK-NAEYMDPHIRLNLERSYEAIIDAGYSM--------PEVRGT--VTGVYV----------------------------------------SAGHYDS--VTFW-QN---L------------GIKN-SADSYKGLGTITNFRATRTSYCMDLRGPS------YTIDTACSGYLAAIDAAIKDIRLGNCCQALVAGIDLQCNP-LSSETLFELGLLGENSRSFSFDEKAE--------------------------------------------------------------------GFARGEAAGVLFLQKEE-D----------------ARR----IHAK-FVHSFQN--SDGKSGG---------LDFNTPSLHGQINSLTECYRQ-A-DVDP-QKIEFVETHG-----------------------------------------------------------------------L-GVKN------------WDTTEANAVT-EVFC-GK-R---R----------------------------------------------------------------A----K-PLMIGSVKTN-VGHAEAASGFNSVAKCVFGMKEGVIPPNIN-FE-----N--PSKDIPGLHDGRLAVPT--ELT-PWSG--E---------LCGINAYS-FGGNNAHVILKK------------------------------------------------------------------------------------------------------- 70 ------------------------ICITGISGRVGQ-A----NNMDEFKDMLW-NKKHAF-T--K-K--FLRF-DLD---KY-------------N-TLKWYAYVN--------DADK-FDPEYFGIEAE-KAQYLDPNIRLSMEAAYEAIVDAGYSM--------EEIRGT--KTGVYC----------------------------------------PCVGYDA--SNYW-FG---K------------GVEE-FGEGS--LGVHNNFRATRISYEMDLRGPS------MAIDTACSGYMAATECALKDIRLGNCDQAIIVGSQLHCNP-IAALLFLDIKAAGPNCICYAFDERAE--------------------------------------------------------------------GMSRGEAIGAMLIQKEE-D----------------ARR----IHTK-VAHAYQS--CDGNSGD---------FDFNHPSVEGQMATIAMCYKQ-S-GVDP-HKLNFVECHG-----------------------------------------------------------------------T-GTVA------------GDSTEVNAID-AIFC-GE-R---R----------------------------------------------------------------T----E-PLMIGSVKTN-MGHAEAVAGFNAIAKCIFSFYENTIPPNIN-FE-----R--PNKEIPGLLDGRLKVPV--ELT-PWNG--T---------MCGVSGFG-LGGTSSHMILKK------------------------------------------------------------------------------------------------------- 71 ------------------------ICITGMSGRVGQ-A----NNLDEYKDKLF-TQKGAY-T--D-K--HLRY-DIE---KY-------------K-TQKIWSYIN--------DADK-FDHEFFGIEAK-KANFLDPNIRLAIEAAYEAIVDAGFSK--------EEIAGT--KTGVYA----------------------------------------PCVDYDA--SNFW-TT---K------------QKED-FGDEV--LGVQNSFRASRISYELDLRGPS------VAFDTACSGSIAAIECAIKDIRTGHCDQAIVAASQLLCSP-YSGKMFYDIGAAADSCVCYAFDTRAE--------------------------------------------------------------------GMSRGEAIGALLIQKEE-D----------------ARR----IHCK-IVHNHQG--SDGNSGD---------FDFNHPSIPGQTAVIKRCYEQ-A-GIDPQTQINYVECHG-----------------------------------------------------------------------T-GTVA------------GDSTEVNAIA-NVFC-GE-R---R----------------------------------------------------------------T----Q-PLTVGSVKPN-MGHTQGAAGFTSIVKCIWCFYENVIPPQMN-FK-----N--YNTTVPAFHDGRIRVIQ-HENM-PWHD--K---------YCGVSGFG-IGGSDSHIILQK------------------------------------------------------------------------------------------------------- 72 ------------------------ICITGMSGRVGQ-C----KNLEEFKDVLM-KGKDAF-T--D-K--SMRF-DID---KY-------------G-TQKEHAYFD--------DAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEASYEAAVDAGFSM--------KELRGS--LTGVYA----------------------------------------SIVTLDA--GNYW-LS---K------------TLDA-IGEASKGLGVIQNFRASRVSYSMDLRGPS------MCVDTGCAGYLSAVEAAVKDIRLGNCDRAIVVCCQLQANP-HGETHFMDLGLSGPNSRCFAFDERAE--------------------------------------------------------------------GFARGEAFGAIMLQTEE-E----------------ARR----VYAK-VVHGYQS--SDGNGGN-------FAVNFSTPSFYGQIDTLKECYRQ-A-GVDP-QTIDFVECHG-----------------------------------------------------------------------L-GTKT------------GDVAEANAVT-EVFC-GK-Q---R----------------------------------------------------------------T----K-PLFIGSVKTN-VGNAEASAGFNSLTKCVMGLNDGVIHPNSN-FE-----K--PNKEIAGLVDGRLKVPT--QPT-PLKG--D---------MCGVSAYS-FGGTNTHLILKK------------------------------------------------------------------------------------------------------- 73 ------------------------ICITGMSGRVGQ-A----NNLDEYKDKLF-TQKGAY-T--D-K--HLRY-DIE---KY-------------K-TQKIWSYIN--------DADK-FDHEFFGIEAK-KANFLDPNIRLAIEAAYEAIVDAGYSK--------EEIAGT--KTGVYA----------------------------------------PCVDYDA--SNFW-ST---K------------GSEE-FGEGS--LGVQNSFRASRISYQLDLRGPS------VAMDTACSGSIAAIECAMKDIRLGNCDQAIIAGSQLLCSP-YSAKMFFDIGAASKSCICYAFDERAE--------------------------------------------------------------------GMSRGEAIGSFFIQKAE-D----------------ARR----IHAK-VVHNHQG--SDGNSGD---------FDFNHPSIPGQTAVIRRCYEQ-A-GIDPQTQIDFVECHG-----------------------------------------------------------------------T-GTVA------------GDSTEVNAIA-NVFC-GE-R---R----------------------------------------------------------------T----T-PLYVGSVKPN-MGHTQGCAGFTSIVKCIWCFYESCLPPNIN-YE-----K--PNRTVPCLLDGRILVAK--EHT-PWNT--K---------MCGVSGFG-IGGTDSHIILKK------------------------------------------------------------------------------------------------------- 74 ------------------------ICITGMSGRVGQ-C----KNLEEFKDVLM-KGKDAF-T--D-K--SMRF-DID---KY-------------G-TQKEHAYFD--------DAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEASYEAAVDAGFSM--------KELRGS--LTGVYA----------------------------------------SIVTLDA--GNYW-LS---K------------TLDA-IGEASKGLGVIQNFRASRVSYSMDLRGPS------MCVDASCAGYLSAIEAAVKDIRLGNCDQAIVVTCQVQANP-LGELHFMDLGLSGPNSRCFAFDEKAE--------------------------------------------------------------------GFARGEAYGAIVLQKEE-D----------------ARR----IHAK-VVHGYQS--CDGNSGN-------FAVEFSTPSFYGQIDTLKECYRQ-A-GVDP-KMIEFVECHG-----------------------------------------------------------------------L-GTKA------------GDTIEANAIT-EVFC-GE-K---R----------------------------------------------------------------T----K-PLMIGSVKTN-VGHAEAAAGFNSTIKCIIGMNEGLIPPNIN-FE-----K--PNKGISGLHDGRLKVPV--EPT-PWSG--D---------MCGISAYG-FGGTNTHIILKK------------------------------------------------------------------------------------------------------- 75 ------------------------ICITGISGRVGQ-A----NNMDEFKDMLW-NKKHAF-T--K-K--FLRF-DLD---KY-------------N-TLKWYAYVN--------DADK-FDPEYFGIEAE-KAQYLDPNIRLSMEAAYEAIVDAGYSM--------EEIRGT--KTGVYC----------------------------------------PCVGYDA--SNYW-FG---K------------GVEE-FGEGS--LGVHNNFRATRISYEMDLRGPS------MAIDTACSGYMAATECALKDIRLGNCDQAIIVGSQLHCNP-IAALLFLDIKAAGPNCICYAFDERAE--------------------------------------------------------------------GMSRGEAIGAMLIQKEE-D----------------ARR----IHTK-VAHAYQS--CDGNSGD---------FDFNHPSVEGQMATIAMCYKQ-S-GVDP-HKLNFVECHG-----------------------------------------------------------------------T-GTVA------------GDSTEVNAID-AIFC-GE-R---R----------------------------------------------------------------T----E-PLMIGSVKTN-MGHAEAVAGFNAIAKCIISFYESTIPPNIN-FE-----K--PNKSIPGLLDGRLKVPV--ELT-PWNG--T---------MCGVSGFG-LGGTSSHLILKK------------------------------------------------------------------------------------------------------- 76 ------------------------ICVTGMSGRVGQ-C----KNLEEFKDVLM-KGKDAF-T--D-K--SMRF-DID---KY-------------G-TQKEHAYFD--------DAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEASYEAAVDAGFSM--------KELRGS--LTGVYA----------------------------------------SIVTLDA--GNYW-LS---K------------TLDA-IGEASKGLGVIQNFRASRVSYSMDLRGPS------MCVDTGCAGYLSAVEAAVKDIRLGNCDRAIVVCCQLQANP-HGETHFMDLGLSGPNSRCFAFDERAE--------------------------------------------------------------------GFARGEAFGAIMLQTEE-E----------------ARR----VYAK-VVHGYQS--SDGNGGN-------FAVNFSTPSFYGQIDTLKECYRQ-A-GVDP-QTIDFVECHG-----------------------------------------------------------------------L-GTKT------------GDVAEANAVT-EVFC-GK-Q---R----------------------------------------------------------------T----K-PLFIGSVKTN-VGNAEASAGFNSLTKCVMGLNDGVIHPNSN-FE-----K--PNKEIAGLVDGRLKVPT--QPT-PLKG--D---------MCGVSAYS-FGGTNTHLILKK------------------------------------------------------------------------------------------------------- 77 ------------------------ICVTGMSGRVGQ-C----KNLEEFKDVLM-KGKDAF-T--D-K--SMRF-DID---KY-------------G-TQKEHAYFD--------DAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEASYEAAVDAGFSM--------KELRGS--LTGVYA----------------------------------------SIVTLDA--GNYW-LS---K------------TLDA-IGEASKGLGVIQNFRASRVSYSMDLRGPS------MCVDASCAGYLSAIEAAVKDIRLGNCDQAIVVTCQVQANP-LGELHFMDLGLSGPNSRCFAFDERAE--------------------------------------------------------------------GFARGEAYGAIVLQKEE-D----------------ARR----IHAK-VVHGYQS--CDGNSGN-------FAVEFSTPSFYGQIDTLKECYRQ-A-GVDP-QMIEFVECHG-----------------------------------------------------------------------L-GTKA------------GDTIEANAIT-EVFC-GE-K---R----------------------------------------------------------------T----K-PLMIGSVKTN-VGHAEAAAGFNSTIKCIIGMNEGLIPPNIN-FE-----K--PNKGISGLHDGRLKVPV--EPT-PWSG--D---------MCGISAYG-FGGTNTHIILKK------------------------------------------------------------------------------------------------------- 78 ------------------------ICITGMSGRVGQ-C----KNLEEFKDVLM-KGKDAF-T--D-K--SMRF-DID---KY-------------G-TQKEHAYFD--------DAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEASYEAAVDAGFSM--------KELRGS--LTGVYA----------------------------------------SIVTLDA--GNYW-LS---K------------TLDA-IGEASKGLGVIQNFRASRVSYSMDLRGPS------MCVDASCAGYLSAIEAAVKDIRLGNCDQAIVVTCQVQANP-LGELHFMDLGLSGPNSRCFAFDERAE--------------------------------------------------------------------GFARGEAYGAIVLQKEE-D----------------ARR----IHAK-VVHGYQS--CDGNSGN-------FAVEFSTPSFYGQIDTLKECYRQ-A-GVDP-QMIEFVECHG-----------------------------------------------------------------------L-GTKA------------GDTIEANAIT-EVFC-GE-K---R----------------------------------------------------------------T----K-PLMIGSVKTN-VGHAEAAAGFNSTIKCIIGMNEGLIPPNIN-FE-----K--PNKGISGLHDGRLKVPV--EPT-PWSG--D---------MCGISAYG-FGGTNTHIILKK------------------------------------------------------------------------------------------------------- 79 ------------------------ICITGMSGRVGQ-C----KNLEEFKDVLM-KGKDAF-T--D-K--SMRF-DID---KY-------------G-TQKEHAYFD--------DAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEASYEAAVDAGFSM--------KELRGS--LTGVYA----------------------------------------SIVTLDA--GNYW-LS---K------------TLDA-IGEASKGLGVIQNFRASRVSYSMDLRGPS------MCVDASCAGYLSAIEAAVKDIRLGNCDQAIVVTCQVQANP-LGELHFMDLGLSGPNSRCFAFDEKAE--------------------------------------------------------------------GFARGEAYGAIVLQKEE-D----------------ARR----IHAK-VVHGYQS--CDGNSGN-------FAVEFSTPSFYGQIDTLKECYRQ-A-GVDP-QMIEFVECHG-----------------------------------------------------------------------L-GTKA------------GDTIEANAIT-EVFC-GE-K---R----------------------------------------------------------------T----K-PLMIGSVKTN-VGHAEAAAGFNSTIKCIIGMNEGLIPPNIN-FE-----K--PNKGISGLHDGRLKVPV--EPT-PWSG--D---------MCGISAYG-FGGTNTHIILKK------------------------------------------------------------------------------------------------------- 80 ------------------------ICITGMSGRVGQ-C----NDLAEFKDMLW-NKKDAY-T--D-K--PMRY-SLD---KW-------------S-DQKEHAFMN--------GCEY-FDNEYFGIAAR-VTEYLDPQVRMNMEASYEAMIDSGYSP--------AELRGS--NVGVYV----------------------------------------AASNYDA--LSYW-QT---L------------GLKD-QREATKGLGSTANFRATRVNYTFDLRGPG------QLIDTNCNGYLAAIDLAIKDIRLGNCCAAFVGVTSLHVNP-LSSELLFQRGMIGENSRCFSFDERAE--------------------------------------------------------------------GFGRGEAVGFLFLQKEE-D----------------ARR----IHAK-IVHSYQN--SEGSNGG----------EFCTPSSKGQIEAMTECYKE-A-NIDP-QNIDFVEAHG-----------------------------------------------------------------------I-GCKD------------WDATEMEAIT-EVFC-SK-K---R----------------------------------------------------------------S----K-PLMIGSVKSN-VGHTECAAGFPSIAKCVFGMKEGMVPPSIN-YK-----T--PSKDIRGLHDGRLSVPT--ELT-QWKG--E---------FCGVNSYS-FGGNNAHLILKK------------------------------------------------------------------------------------------------------- 81 ------------------------ICITGMSGRVGQ-C----NDLAEFKDMLW-SKKDAY-T--D-K--PMRY-SLD---KW-------------S-DQKEHAFMN--------GCEY-FDNEYFGIAAR-VTEYLDPQVRMNMEASYEAMIDSGYSP--------AELRGS--NVGVYV----------------------------------------AASNYDA--LSYW-QT---L------------GLKD-QREATKGLGSTANFRATRVNYTFDLRGPG------QLIDTNCNGYLAAIDLAIKDIRLGNCCAAFVGVTSLHVNP-LSSELLFQRGMIGENSRCFSFDERAE--------------------------------------------------------------------GFGRGEAVGFLFLQKEE-D----------------ARR----IHAK-IVHSYQN--SEGSNGG----------EFCTPSSKGQIEAMTECYKE-A-NIDP-QNIDFVEAHG-----------------------------------------------------------------------I-GCKD------------WDATEMEAIT-EVFC-SK-K---R----------------------------------------------------------------S----K-PLMIGSVKSN-VGHTECAAGFPSIAKCVFGMKEGMVPPSIN-YK-----T--PSKDIRGLHDGRLSVPT--ELT-QWKG--E---------FCGVNSYS-FGGNNAHLILKK------------------------------------------------------------------------------------------------------- 82 ------------------------ICITGMSGRVGQ-C----NDLAEFKDMLW-NKKDAY-T--D-K--PMRY-SLD---KW-------------S-DQKEHAFMN--------GCEY-FDNEYFGIAAR-VTEYLDPQVRMNMEASYEAMIDSGYSP--------AELRGS--NVGVYV----------------------------------------AASNYDA--LSYW-QT---L------------GLKD-QREATKGLGSTANFRATRVNYTFDLRGPG------QLIDTNCNGYLAAIDLAIKDIRLGNCCAAFVGVTSLHVNP-LSSELLFQRGMIGENSRCFSFDERAE--------------------------------------------------------------------GFGRGEAVGFLFLQKEE-D----------------ARR----IHAK-IVHSYQN--SEGSNGG----------EFCNPSATGQIEAMKECYKE-A-NIDP-QNIDFVEAHG-----------------------------------------------------------------------I-GCKD------------WDATEMEAIT-EVFC-SK-K---R----------------------------------------------------------------S----K-PLMIGSVKSN-VGHTECAAGFPSIAKCVFGMKEGMVPPSIN-YK-----T--PSKDIRGLHDGRLSVPT--ELT-QWKG--E---------FCGVNSYS-FGGNNAHLILKK------------------------------------------------------------------------------------------------------- 83 ------------------------ICITGMSGRVGQ-C----KNLEEFKEMLM-KGKHAF-T--D-K--SMRF-DID---KY-------------G-TQKEHAYFD--------DAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEASYEAAVDAGFSM--------KELRGS--LTGVYA----------------------------------------SIVTLDA--GNYW-LS---K------------TLDA-IGEASKGLGVIQNFRASRVSYSMDLRGPS------MCVDASCAGYLSAIEAAVKDIRLGNCDQAIVVTCQVQANP-LGELHFMDLGLSGPNSRCFAFDERAE--------------------------------------------------------------------GFARGEAYGAIVLQKEE-D----------------ARR----IHAK-VVHGYQS--CDGNSGN-------FAVEFSTPSFYGQIDTLKECYRQ-A-GVDP-QMIEFVECHG-----------------------------------------------------------------------L-GTKA------------GDTIEANAIT-EVFC-GE-K---R----------------------------------------------------------------T----K-PLMIGSVKTN-VGHAEAAAGFNSTIKCIIGMNEGLIPPNIN-FE-----K--PNKGISGLHDGRLKVPV--EPT-PWSG--D---------MCGISAYG-FGGTNTHIILKK------------------------------------------------------------------------------------------------------- 84 ------------------------ICVTGMSGRVGQ-C----KNLEEFKEMLM-KGKHAF-T--D-K--SMRF-DID---KY-------------G-TQKEHAYFD--------DAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEASYEAAVDAGFSM--------KELRGS--LTGVYA----------------------------------------SIVTLDA--GNYW-LS---K------------TLDA-IGEASKGLGVIQNFRASRVSYSMDLRGPS------MCVDTGCAGYLSAVEAAVKDIRLGNCDRAIVVCCQLQANP-HGETHFMDLGLSGPNSRCFAFDERAE--------------------------------------------------------------------GFARGEAFGAIMLQTEE-E----------------ARR----VYAK-VVHGYQS--SDGNGGN-------FAVNFSTPSFYGQIDTLKECYRQ-A-GVDP-QTIDFVECHG-----------------------------------------------------------------------L-GTKT------------GDVAEANAVT-EVFC-GK-Q---R----------------------------------------------------------------T----K-PLFIGSVKTN-VGNAEASAGFNSLTKCVMGLNDGVIHPNSN-FE-----K--PNKEIAGLVDGRLKVPT--QPT-PLKG--D---------MCGVSAYS-FGGTNTHLILKK------------------------------------------------------------------------------------------------------- 85 ------------------------ICITGMSGRVGQ-A----NNLDEYKDKLF-TQKGAY-T--D-K--HLRY-DIE---KY-------------K-TQKIWSYIN--------DADK-FDHEFFGIEAK-KANFLDPNIRLAIEAAYEAIVDAGFSK--------EEIAGT--KTGVYA----------------------------------------PCVDYDA--SNFW-TT---K------------QKED-FGDEV--LGVQNSFRASRISYELDLRGPS------VAFDTACSGSIAAIECAIKDIRTGHCDQAIVAASQLLCSP-YSGKMFYDIGAAADSCVCYAFDTRAE--------------------------------------------------------------------GMSRGEAIGALLIQKEE-D----------------ARR----IHCK-IVHNHQG--SDGNSGD---------FDFNHPSIPGQTAVIKRCYEQ-A-GIDPQTQINYVECHG-----------------------------------------------------------------------T-GTVA------------GDSTEVNAIA-NVFC-GE-R---R----------------------------------------------------------------T----Q-PLTVGSVKPN-MGHTQGAAGFTSIVKCIWCFYENVIPPQMN-FK-----N--YNTTVPAFHDGRIRVIQ-HENM-PWHD--T---------YCGVSGFG-IGGSDSHIILQK------------------------------------------------------------------------------------------------------- 86 ------------------------ICVTGMSGRVGQ-C----KNLELFKEMLM-KGKHAF-T--D-K--SMRF-DID---KY-------------G-TQKEHAYFD--------DAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEASYEAAVDAGFSM--------KELRGS--LTGVYA----------------------------------------SIVTLDA--GNYW-LS---K------------TLDA-IGEASKGLGVIQNFRASRVSYSMDLRGPS------MCVDTGCAGYLSAVEAAVKDIRLGNCDRAIVVCCQLQANP-HGETHFMDLGLSGPNSRCFAFDERAE--------------------------------------------------------------------GFARGEAFGAIMLQTEE-E----------------ARR----VYAK-VVHGYQS--SDGNGGN-------FAVNFSTPSFYGQIDTLKECYRQ-A-GVDP-QTIDFVECHG-----------------------------------------------------------------------L-GTKT------------GDVAEANAVT-EVFC-GK-Q---R----------------------------------------------------------------T----K-PLFIGSVKTN-VGNAEASAGFNSLTKCVMGLNDGVIHPNSN-FE-----K--PNKEIAGLVDGRLKVPT--QPT-PLKG--D---------MCGVSAYS-FGGTNTHLILKK------------------------------------------------------------------------------------------------------- 87 ------------------------ICITGMSGRVGQ-C----KNLELFKEMLM-KGKHAF-T--D-K--SMRF-DID---KY-------------G-TQKEHAYFD--------DAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEASYEAAVDAGFSM--------KELRGS--LTGVYA----------------------------------------SIVTLDA--GNYW-LS---K------------TLDA-IGEASKGLGVIQNFRASRVSYSMDLRGPS------MCVDASCAGYLSAIEAAVKDIRLGNCDQAIVVTCQVQANP-LGELHFMDLGLSGPNSRCFAFDEKAE--------------------------------------------------------------------GFARGEAYGAIVLQKEE-D----------------ARR----IHAK-VVHGYQS--CDGNSGN-------FAVEFSTPSFYGQIDTLKECYRQ-A-GVDP-QMIEFVECHG-----------------------------------------------------------------------L-GTKA------------GDTIEANAIT-EVFC-GE-K---R----------------------------------------------------------------T----K-PLMIGSVKTN-VGHAEAAAGFNSTIKCIIGMNEGLIPPNIN-FE-----K--PNKGISGLHDGRLKVPV--EPT-PWSG--D---------MCGISAYG-FGGTNTHIILKK------------------------------------------------------------------------------------------------------- 88 ------------------------ICVTGMSGRVGQ-C----KNLEEFKDVLM-KGKDAF-T--D-K--SMRF-DID---KY-------------G-TQTEHAYFE--------DAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEASYEAAVDAGFSM--------KELRGS--LTGVYA----------------------------------------SIVTLDA--GNYW-LS---K------------TLDA-IGEASKGLGVIQNFRASRVSYSMDLRGPS------MCVDTGCAGYLSAVEAAVKDIRLGNCDRAIVVCCQLQANP-HGETHFMDLGLSGPNSRCFAFDERAE--------------------------------------------------------------------GFARGEAFGAIMLQTEE-E----------------ARR----VYAK-VVHGYQS--SDGNGGN-------FAVNFSTPSFYGQIDTLKECYRQ-A-GVDP-QTIDFVECHG-----------------------------------------------------------------------L-GTKT------------GDVAEANAVT-EVFC-GK-Q---R----------------------------------------------------------------T----K-PLFIGSVKTN-VGNAEASAGFNSLTKCVMGLNDGVIHPNSN-FE-----K--PNKEIAGLVDGRLKVPT--QPT-PLKG--D---------MCGVSAYS-FGGTNTHLILKK------------------------------------------------------------------------------------------------------- 89 ------------------------ICITGMSGRVGQ-C----KNLEEFKDVLM-KGKDAF-T--D-K--SMRF-DID---KY-------------G-TQTEHAYFE--------DAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEASYEAAVDAGFSM--------KELRGS--LTGVYA----------------------------------------SIVTLDA--GNYW-LS---K------------TLDA-IGEASKGLGVIQNFRASRVSYSMDLRGPS------MCVDASCAGYLSAIEAAVKDIRLGNCDQAIVVTCQVQANP-LGELHFMDLGLSGPNSRCFAFDEKAE--------------------------------------------------------------------GFARGEAYGAIVLQKEE-D----------------ARR----IHAK-VVHGYQS--CDGNSGN-------FAVEFSTPSFYGQIDTLKECYRQ-A-GVDP-KMIEFVECHG-----------------------------------------------------------------------L-GTKA------------GDTIEANAIT-EVFC-GE-K---R----------------------------------------------------------------T----K-PLMIGSVKTN-VGHAEAAAGFNSTIKCIIGMNEGLIPPNIN-FE-----K--PNKGISGLHDGRLKVPV--EPT-PWSG--D---------MCGISAYG-FGGTNTHIILKK------------------------------------------------------------------------------------------------------- 90 ------------------------ICITGISGRVGK-A----NNLDEFKDILW-NKKHGF-T--D-K--PLRF-DFD---KY-------------H-TQKWFAYIN--------DAEK-FDPEFFGIEAK-KANYLDPNIRLSIEAAYEAIVDAGYSM--------EEVRGT--KTGVYA----------------------------------------PCVGYDA--SNYW-GY---K------------GVEE-FGEGS--LGVQNSFRAHRISYEMDLRGPS------MAIDTACSGYLAAVECALKDIRLGNCDQAIVAGSQLHCNP-IAAKMFLDIKAAGPNCTCYAFDERAE--------------------------------------------------------------------GMSRGEAIGTLFIQKEC-D----------------ARR----IHTK-VAHAYQS--CDGNSGE---------FDFNHPSVEGQMATIATCYRQ-A-GVDP-HKINYVECHG-----------------------------------------------------------------------T-GTVA------------GDSTEVNAIT-NIFC-GE-R---R----------------------------------------------------------------T----E-PLMIGSVKTN-MGHAEAVAGFNAIAKCIISFYESTIPPNIN-FE-----K--PNKSIPGLLDGRLKVNV--ELT-PWND--T---------MCAVSSFG-LGGTSSHLILKK------------------------------------------------------------------------------------------------------- 91 ------------------------ICITGMSGRVGQ-C----RDLDEFKEMLW-NKKDAF-T--D-K--PMRF-NTD---KY-------------N-KQKEHAYME--------DTES-FDSDYFGIAPK-NAEYMDPHIRLNLEHSYEAIIDAGYSM--------PEVRGT--VTGVYV----------------------------------------SAGHYDS--VTFW-QN---L------------GIRN-SADSTKGLGTITNFRATRISYCMDLRGPS------YIIDTACSGYLAAIDAAIKDIRLGNCCQALVATTDLQCNP-LSSETFFELGLLGENSRSFSFDEKAE--------------------------------------------------------------------GFARGEAAGVLFLQKEE-D----------------ARR----IHAK-FVHSFQN--SDGKSGG---------LDFNTPSLHGQINSLTECYRQ-A-DVDP-QKIEFVETHG-----------------------------------------------------------------------L-GVKD------------WDTTEANAVT-EVFC-GK-R---R----------------------------------------------------------------A----K-PLMIGSVKTN-VGHAEASAGFNSVAKCVFGMKEGVIPPNIN-FE-----K--PSKDIPGLHDGRLAVPT--ELT-PWSG--E---------LCGINAYS-FGGNNAHVILKK------------------------------------------------------------------------------------------------------- 92 ------------------------ICITGMSGRVGQ-C----KNLDEFKDMLM-KGKDAF-T--D-K--SMRF-DID---KY-------------G-TQKEHAYFE--------EAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEAAYEAVVDAGYSM--------QEVRGT--LTGVYA----------------------------------------SVCTLDA--SNYW-LS---K------------SLDA-ITEASKGLGVIHNFRASRVSYAMDLRGPS------MCVDTACAGYLSAIEAAVKDIRLGNCDRAIVVTSQLEANP-MSEQHFIDLGLSGPNSKCFSFDERAE--------------------------------------------------------------------GFARGEAMGAIMLHKEE-E----------------ARR----IYAK-VAHGYQS--CDGNSGD-------FALEFSTPSFYGQIDTLKECYRQ-A-GVDP-QTIEFVECHG-----------------------------------------------------------------------L-GTKV------------GDTTEANAIT-EVFC-GK-Q---R----------------------------------------------------------------T----K-PLIIGSVKTN-AGHADAAAGFNATIKCVMALNEGVIPPNLN-FE-----K--PNKEIPGLHDGRLKVPV--EPT-PWSG--D---------MCGISAYS-YGGTNTHLILKK------------------------------------------------------------------------------------------------------- 93 ------------------------VCITGMSGRIGQ-C----NNLDEFKEMLM-KGKDAF-T--D-K--SMRF-DID---KY-------------G-TQKKHAYFE--------DADK-FDNDYFGIAPK-NCDFMDPNIRLSMEASYEAIVDAGLSM--------TEVRGT--LTGVYA----------------------------------------SIVTLDA--GNYW-LS---K------------SIDA-IGEAKLGLGVIQNFRASRVSYAMDLRGPS------MCVDTGCAGYLSAIEAAMKDIRLGNCDQAVVVTCQLEANP-ISEQHFMDLGLSGPNSKCYAFDERAE--------------------------------------------------------------------GFARGEALGALFLQREE-D----------------SRR----IYAK-VAHGYQS--CDGNSG----------VDFSTPSFIGQIDTLKECYRQ-A-GVDP-QTIEFVECHG-----------------------------------------------------------------------L-GTKG------------GDITEANAIT-EVFC-GK-Q---R----------------------------------------------------------------T----K-PLMIGSVKTN-VGHAQGAAGFNSTVKCIIGMNEGVIPPNIN-FE-----K--PNKEIHGLHDGRLKVPV--EPT-PWSG--D---------MCGISGIG-YGGSNTHIILKK------------------------------------------------------------------------------------------------------- 94 ------------------------IAIVGIGCKVP-G-A---DNVEQFWRVLE-QGENHV-VEIP-K--E-RW-NNDA--FFD----TDVHAVGKS-YVKRAGLL-----K-D--PK-AFDNKLFNINDF-EADQMDPQQRFVLECCFMAMEDAGITR--------EQLAG--SNTGVYV---------------------------------------G-AMNGDY--RALF-TA-----------K----S--P-IVGNYTVTGISNSIISARVSFTFDLRGPS------MTLDTACSSALVAIHVGAQALRTGDCDLALCGGTNFLMSP-DVFVHLSKAHMVSPTGQCFAFSDSAD--------------------------------------------------------------------GYTRGEGCGMVILKRLK-D--------------A--LRDGDHIWA-TIE-TGSN--QDGHSVT-------P---ISAPSGDQQLRLLETVYQD-A-AMDL-EGIDYIEAHG-----------------------------------------------------------------------T-GTSA------G------DPVEAKALG-TFFR-SK---G----T------------------------------------------------------------T-----R-QRYIGSVKTN-VGHLESAAGTAGLIKVLLMMKHSKIAPSLF-FD-----R--PNPKID-FPDLNLQVPT--KAM-DWPR--R-------NKIACVNSFG-FGGTNCHAVVKA------------------------------------------------------------------------------------------------------- 95 ------------------------ICVTGMAGRVGQ-A----RTLTDVKHALW-NKQEVF-T--T-K--PMRF-DIE---KY-------------G-TQKQHAYID--------DAEY-FDNDYFGIAPK-NAEFLDPNIRLSLEGAYEAVVDAGYSM--------QEIRGT--NTGVYV----------------------------------------PCVAYDA--NCYW-LS---K------------GLEV-IGEAKKGMGVVNNFRASRISYAMDLRGPS------VCVDTACSGYLAALETAMKDIRMGVADSAIVACCQLHCNP-MSSLLFIELGAAGPDAKCYTFDERAQ--------------------------------------------------------------------GFGRGEAVGAVLLQKEE-D----------------ARR----VYCK-LAHCFQS--CDGNSGD---------FDFNHPSVIGQMHTINECYRQ-C-GIDP-QVVEYVECHG-----------------------------------------------------------------------T-GTSA------------GDTVEANAVT-NVFC-GK-R---R----------------------------------------------------------------K----S-PLLVGSIKTN-VGHAEAAAGFNALVKCVFGMEEGVIPPNLN-FE-----R--PNREIPGLLDGRLKVVT--EMT-PWTG--R---------VCGISGFG-IGGTNSHVILKK------------------------------------------------------------------------------------------------------- 96 ------------------------IVVSGMSGRIGQ-C----DTLADYKDILW-NKKDAF-T--E-K--SMRY-DIE---LY-------------K-TQKSHAYIN--------DAEK-FDSDYFGIAPK-NAEFLDPCIRLGMEAAYEAVVDGGYSM--------QEMRGT--MTGVYV----------------------------------------PCVAYEA--NCYW-LS---K------------GLDV-IGTASRGLGVINNFRASRISFSMDLRGPS------MCVDTACSGYLAAVETAVKDIRLGLCEQAIVASCQMHCNP-MGSLLFMELGAAGPDARCYSFDHRAQ--------------------------------------------------------------------GFGRCEAVGAMLIQKEG-D----------------ARR----VYCK-IPHVYQS--CDGASTE---------HDFNHPSEIGQKHTIEECYRQ-A-DIDI-SKVEFVECHG-----------------------------------------------------------------------T-GTKA------------GDSVEASAID-SAFC-SK-P---R----------------------------------------------------------------A----K-PLMIGSCKTN-VGHAEASAGFNAMVKCIFSINECVIPPNIN-FE-----K--PNPAIAGLLEGRLKVPT--ELT-PWSG--E---------ICGISGFG-IGGTNSHMILKK------------------------------------------------------------------------------------------------------- 97 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAICGGTNYLTIP-DVFIHLSKAGMISPTGQCHSFSNKAD--------------------------------------------------------------------GYTRGEGCGIVILKKLQ-D--------------A--ERAGDKIWA-TIY-TGCN--QDGHSVA-------P---ITAPSGFQQASLLDDVFSR-I-GLDP-SRIDYIEAHG-----------------------------------------------------------------------T-GTNA------G------DPVEVNTLG-EFFK-TR---A----T------------------------------------------------------------P-----R-QRYLGSVKTN-IGHLESAAGVIGVIKVLLMMKNNKIVPSLH-CD-----E--PNPKIN-FPELMLTVPG--KTI-DWDN--P-------DKVSCCNSFG-FGGSNSHAVVC-------------------------------------------------------------------------------------------------------- 98 ------------------------VAIVGIGCRFP-GRV---NSPADMWDVLV-EGRDCL-EPIP-D----RW-NVEA--YYS----PDPHSLGTH-VNKKGGFVK------D--VD-FFDNGFFKIAPK-EALNMDPQQRQLLEVTHEAFEDAGVVP--------SRLGG---KCGVYV---------------------------------------G-IGMMDY--PLLN-SS---D------------P--R-NFNAYSHTGMAHSVAANRISFAFNLRGPS------LATDTACASSMTALHLACTGLWNKECEASIVAGSNILLMP-EITCGFSALSVLSPESQSRPFDADAK--------------------------------------------------------------------GYVRSEGFSALLLKPLE-A--------------A--LRDGDHIYC-TVLGTGIA--ANGLTP--------S---ITMPSKDAQAQLMTSVYDQ-F-HVSK-EKLIYVEAHG-----------------------------------------------------------------------T-GTPV------------GDPIEAEAIG-AALA-EG--R------------------------------------------------------------------D-----E-PLRIGSAKSN-FGHLECAAGVVSLVKAALMLKHRKLVPSIN-FR-Q------PATPL--FSGWNVQVQT--KVE-DFPE--G------Q-HLIAVNNYG-FGGALAHAVLKEAP----------------------------------------------------------------------------------------------------- 99 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATP-DIFVHLSKARMISPTGQCHAFSDQAD--------------------------------------------------------------------GYTRGEGCGIVILKKLS-D--------------A--ERDKDRILA-VVK-TGSN--QDGHTVT-------P---ISAPSQSQQIQLLDDMYRE-F-SLEQLDEMEYIEAHG-----------------------------------------------------------------------T-GTQA------G------DYAEANALG-KFFK-KR---G----S------------------------------------------------------------T-----K-NRLIGSIKTN-IGHLESAAGVAGLIKVILMMEQNKIVPSLF-SQ-----N--PNKRIP-FDKLNLVVAS--EVR-DWTT--E-------KKVASVNSFG-FGGSNCHAIVRSY------------------------------------------------------------------------------------------------------ 100 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CSSALIAIHTASQGLLNGDCTMALCGGTNFIGSP-DIFIHLSKAQMVSPTGQSHAFSELAD--------------------------------------------------------------------GYTRGEGCGIVILKKLS-D--------------A--ERNNDRILA-VIK-TGTN--QDGHTVT-------P---ISAPSMSQQIQLLEEMYRH-F-SVEELDEIEYIEAHG-----------------------------------------------------------------------T-GTQA------G------DYAEANALG-QFFK-SR---G----S------------------------------------------------------------S-----K-KRLIGSIKTN-IGHLESAAGVAGLIKVLLMMEHSKVVPSLF-SE-----K--LNTRID-FEGLNLAVAS--KVD-GWTT--G-------KKVASVNSFG-FGGSNCHAIVRS------------------------------------------------------------------------------------------------------- 101 ------------------------IAIIGMGCRFP-G-A---TCLEEFWDVLA-KGENHV-VDIP-P--E-RW-NMDA--FFD----SDVNAAGKS-YARKAGLI-----E-N--FD-HFDNKLFKINET-EAAQMDPQQRQVLECTYMALEDAGITR--------QQIAG--QKVGVFI---------------------------------------G-NMAVDY--GLLI-SD-----------V----S--P-DVSNYTVTGQGGSIISNRVSFVYNLAGPS------MTIDTACSSSIVAIHQAGLALRAGDCSMAICGGVNLLLHP-GYFIKLSKARMLSPTGQCHAFSANAD--------------------------------------------------------------------GYTRGEGCGIVIVKLLS-E--------------A--LHDGDNIWG-TIV-TGLN--QDGRQVT-------P---ITAPSGKQQQELLNDIYTR-H-GIDP-TEVDYIEAHG-----------------------------------------------------------------------T-GTRL------G------DPVEATALG-TFFE-KF--PR-Q------------------------------------------------------------------------RHIGSVKTN-IGHLEAAAGVAGLIKVLLMMKHSTIVPSLH-FD-KP------NEDID-FDRFRFVVPV--ENV-DWKR--E-------KKIACINSFG-FGGSNSHAVLQSY------------------------------------------------------------------------------------------------------ 102 ------------------------------------------XNVEQYWNLLE-KGENHV-IDIP-K--E-RW-NNDA--FYD----PDPHAIGKS-YVRRAGLL-----K-D--PL-AFDNKLFNINDF-EADQMDPQQRFVLECSFMAMEDAGITR--------DKLAG--SNTGVYI---------------------------------------G-AMNGDY--RGLF-TA-----------K----S--P-IVGNYTVTGISNSIIAARISFTFDLRGPS------MTLDTACSSALLAIHIGAQALRTGDCDMALCGGTNFLMSP-DVFVHLSKAHMVSPTGQCFAFSDSAD--------------------------------------------------------------------GYTRGEGCGMVVLKRLK-D--------------A--IRDGDRIWA-TIE-TGSN--QDGHSVT-------P---ISAPSGDQQIKLLDHVYRN-T-QEKLIDRIDYIEAHG-----------------------------------------------------------------------T-GTAA------G------DPVEANALG-KFFQ-ER---G----A------------------------------------------------------------V-----R-HRYIGSVKTN-LGHLESAAGTAGLIKVLLMMKHSKIVPSLF-FD-----R--PNPKIK-FPDMNLTVPT--TVV-DWPT--Q-------NKVACVNSFG-FGGTNCHAVVQAY------------------------------------------------------------------------------------------------------ 103 ------------------------IAIVGIGCRMP-GDV---NSPEAFWEVLV-QGRDVL-TEVP-P--D-RW-SLEA--YYN----PDPASLGTH-VNKRGGFIK------D--MD-RFDNGFFKISPK-EAAMMDPQQRHLLEVTHEAFEDAGIET--------EKLGE---RCGVYV---------------------------------------G-IGMMDY--PLML-GP---D------------S--T-NFNAYAHTGVAHSVAANRISFAFNLQGPS------VAVDTACAASMTALHFGCQALWNSECGVSVVAGSNVLLMP-EVTAGFSALSVLSPEGQSRPFDVNAK--------------------------------------------------------------------GYVRSEGFGAVILKPLA-Q--------------A--LRDGDNIYC-TVLGSGIA--SNGATP--------S---ITMPSCDAQVRLMTSVYQQ-F-KIDA-ERLIYVEAHG-----------------------------------------------------------------------T-GTPV------------GDPIEAEAIG-RALA-RD--R------------------------------------------------------------------Q-----Q-PLRIGSAKSN-FGHMECCAGMVSIIKTALMLKHRKICPSIN-FT-A------PIDER--FKDWNIDVQT--KME-DFPA--G------RNHMIGVNNYG-FGGALAHAVLGEI------------------------------------------------------------------------------------------------------ 104 ------------------------IAIVGIGCRMP-GDV---NSPEAFWDVLM-QGRDVL-SEVP-P--E-RW-SLEA--YHN----PDPASLGTH-VNKRGGFIR------D--MD-RFDNGFFKISPK-EAAMMDPQQRHLLEVTHEAFEDAGIET--------DRLGE---KCGVYV---------------------------------------G-IGMMDY--PLML-GP---D------------S--T-NFNAYAHTGVAHSVAANRISFAFNLQGPS------VAVDTACAASMTALHFGCQALWNSECGVSVVAGSNVLLMP-EVTAGFSALSVLSPEGQSRPFDVNAK--------------------------------------------------------------------GYVRSEGFGAIIIKPLA-Q--------------A--LKDGDNVYC-TIMGSGIA--SNGATP--------S---ITMPSCGAQQRLMTSVYEQ-F-KIEP-ERLIYVEAHG-----------------------------------------------------------------------T-GTPV------------GDPMEAEAIG-NALA-AG--R------------------------------------------------------------------E-----Q-PLKIGSAKSN-FGHMECCAGMVSIIKTALMLKHRKICPSIN-YT-A------PIDER--FKEWNIDVQT--KVE-DFPA--G------RNHLIGVNNYG-FGGALAHAVLGEI------------------------------------------------------------------------------------------------------ 105 ------------------------IAIVGIGCRMP-GDV---NSPEAFWDVLV-QGKDVL-SEVP-P--E-RW-SLEA--YHN----PDPASLGTH-VNKRGGFIR------D--MD-RFDNGFFKISPK-EAAMMDPQQRHLLEVTHEAFEDAGIET--------DRLGE---KCGVYV---------------------------------------G-IGMMDY--PLML-GP---D------------S--T-NFNAYAHTGVAHSVAANRISFAFNLQGPS------VAVDTACAASMTALHFGCQALWNSECGVSVVAGSNVLLMP-EVTAGFSALSVLSPEGQSRPFDVNAK--------------------------------------------------------------------GYVRSEGFGAIIIKPLA-Q--------------A--MKDGDNIYC-TIMGSGIA--SNGATP--------S---ITMPSCNAQERLMTSVYEQ-F-KIDP-ERLIYVEAHG-----------------------------------------------------------------------T-GTPV------------GDPMEAEAIG-KALA-AG--R------------------------------------------------------------------D-----K-PLKIGSAKSN-FGHMECCAGMVSIIKTALMLKHRKICPSIN-FT-A------PIDER--FKEWNIDVQT--KVE-DFPA--G------KNHLIGVNNYG-FGGALAHAVLGEI------------------------------------------------------------------------------------------------------ 106 ------------------------IAIVGIGCKVP-G-A---DNVEQFWKVLE-RGENHV-IDIP-K--D-RW-NNDA--FYD----PDPHAVGKS-YVRRAGLL-----K-D--PI-AFDNKLFNINDF-ESDQMDPQQRYVLECSFMAMEDAGITR--------DKLAG--SNTGVYV---------------------------------------G-AMNGDY--RGLF-TA-----------K----S--S-IVGNYTVTGISNSIIAARVSFVFDLRGPS------MTLDTACSSALLAIHIGAQALRTGDCDIALCGGTNFLMAP-DVFVHLSKAHMVSPTGQCFAFSDSAD--------------------------------------------------------------------GYTRGEGCGMVILKRLS-D--------------A--LRDGDRVWA-TVD-TGSN--QDGHSVT-------P---ISAPSGDQQIKLLEHVYKN-A-DIDV-NRIDYIEAHG-----------------------------------------------------------------------T-GTSA------G------DPVEANALG-KFFQ-EK---G----A------------------------------------------------------------V-----R-HRYIGSVKTN-LGHLESAAGTAGLIKVLLMMKHSKIVPSLF-FD-----N--PNPKIN-FPEMNLSVPT--KVV-DWPS--Q-------NKVACVNSFG-FGGTNCHAVVKAY------------------------------------------------------------------------------------------------------ 107 ------------------------IAILGAGFKGP-G-A---DNLEELWRVLE-RGENHV-TDIP-K--E-RW-NNDA--FYD----PDPQAVTKS-YVCKGGFM-----S-K--PF-AFDNSFFGINDM-ESDQMDPQQKHALECTYRALEHAGLNK--------QDLKG--SNTGVYI---------------------------------------G-AMNSDY--RSMY-QA-----------R----S--S-GVTNYTVTGISNSIIAARISFFFDLRGPA------LVLDTGCSSALIAIHTASQALRAGDCDLAICGGTNFMMTP-DIFVHLSKAKMVSPTGQCYAFSDRAD--------------------------------------------------------------------GYTRGEGCGIVVLKKLS-D--------------A--QRDGDRVMV-TIE-TGTN--QDGHSVT-------P---ISAPSMKQQLSLLEHTYRN-L-TDQELEELDYIEAHG-----------------------------------------------------------------------T-GTIT------G------DPTEANALG-QFFQ-QR---G----S------------------------------------------------------------K-----K-LRIMGSIKTN-IGHLESAAGVAGLVKVLLMMEHSKIVPSLF-SE-----D--PNKKIK-FDKLNLTLPT--KVV-DWRK--D-------QHVACVNSFG-FGGSNCHAIIKS------------------------------------------------------------------------------------------------------- 108 ------------------------IAIVGIGCRTP-G-A---DNIQEFWRVLQ-NGECHI-TDVP-A--D-RW-NAKA--FLD----PDPMAPGKA-YVQKGGFL-----K-D--VE-GFDNRLYGINDY-EASSMDPQQCQLLECTTMAMQDAGITS--------AHLSG--SNTGVYI---------------------------------------G-SMNNDY--GSTF-LG-----------K----T--T-KVDNYTATGTSNTILASRLSYVFNLTGPC------MVLDTACSASLIAIHQGCQAIRSGDCNAAICGGVNCMLTP-DAFIQLSKSRMISPTGLCHTFSDQAD--------------------------------------------------------------------GYTRGEGCGVVILKRLT-D--------------A--IRDGDNIRA-IVY-TGTN--QDGHSVT-------P---MTAPSGEQQKKLLHSVYDK-F-QVDV-SHVDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEANSLG-SFFK-EK---G----P------------------------------------------------------------P-----R-ERYIGSVKTN-IGHTESAAGVLGLIKVLLMMEHNLIVPSLH-C---D--V--ANPKID-LSGHKLVVPK--NLI-PWTK--S-------HKVAACNSFG-FGGSNSHAVVRSY------------------------------------------------------------------------------------------------------ 109 ------------------------IAIVGIGCRTS-G-A---DNIREFWHLLQ-NGECHV-GDVP-K--N-RW-NKDA--FFS----EDHSAYGRA-YVQKGGFM-----K-D--VE-GFDNGLYAINDY-EASHMDPQQCLLLECTSMALEDAGITR--------KQLAG--SSTGVYI---------------------------------------G-SMNSDH--RSSS-LG-----------M----T--S-KVGSYTASSSASSFLSCRLSYVFDLRGPS------MTVDTACSAALVAIHLGRQAILTGDCEQAICGGVNCMMLP-DVFIHLSKARMISPTGQCHTFSDKAD--------------------------------------------------------------------GYTRGEGCGIVILKRLT-D--------------A--LRDGDHIWS-TIS-TGTN--QDGRSVS-------P---VTAPSGEQQMKLLHSVYNK-F-PVDL-SRLDYIEAHG-----------------------------------------------------------------------T-GTPT------G------DPVEVNALG-TFLK-ER---G----Q------------------------------------------------------------A-----R-QRYLGSAKTN-IGHTESAAGVLSVIKLCLMMKHDTIVPSLH-C---D--V--VNPNIK-LTDLNFVIPK--APV-TWSA--P-------DKLCCCNSFG-FGGTNCHAILQS------------------------------------------------------------------------------------------------------- 110 ------------------------IAIVGIGCKVP-G-A---DNIEQFWNLLE-NGENHV-IEIP-K--N-RW-NNEA--FYD----PDPHATGKT-NVRCAGLL-----K-D--PY-AFDNKLFNINDF-EADQMDPQQRLVLECSHMAMEDAGLTR--------DKLSG--SNTGVYV---------------------------------------G-AMNGDY--RGLF-TA-----------K----S--P-SVGNYTVTGISNSIIAARVSFTFDLRGPS------MTVDTACSSALLAIHIGAQALRAGDCDVALCGGTNFLMSP-DVFVHLSKAHMVSPTGQCFAFSDTAD--------------------------------------------------------------------GYTRGEGCGMVFLKRLE-D--------------A--LRDGDKIWA-TVE-TGSN--QDGHSVT-------P---ISAPSGDQQIKLLEHVYRH-A-SSCTLDTIDYIEAHG-----------------------------------------------------------------------T-GTAA------G------DPVEANALG-TFFK-DK---G----S------------------------------------------------------------I-----R-HRYIGSVKTN-LGHLESAAGTAGLIKVLLMMKHSKIVPTLF-FE-----R--CNPKID-FPSMNLSVPT--KVI-DWPT--H-------NKAACVNSFG-FGGTNCHAFVKT------------------------------------------------------------------------------------------------------- 111 ------------------------VAIVGIGCRFP-GRV---NSPADMWDVLV-EGRDCL-EPIP-D----RW-NVDA--YYS----PDPHSLGTH-VNKKGGFVK------D--VD-FFDNGFFKIAPK-EALNMDPQQRQLLEVTHEAFEDAGVVP--------SRLGG---KCGVYV---------------------------------------G-IGMMDY--PLLN-SS---D------------P--R-NFNAYSHTGMAHSVAANRISFAFNLRGPS------LATDTACASSMTALHLACMGLWNKECEASIVAGSNILLMP-EITCGFSALSVLSPESQSRPFDADAK--------------------------------------------------------------------GYVRSEGFSALLLKPLD-A--------------A--LRDGDHIYC-TVRGTGIA--ANGLTP--------S---ITMPSKDAQAQLMTSVYEQ-F-HLPK-EKLVYVEAHG-----------------------------------------------------------------------T-GTPV------------GDPIEAEAIG-AALA-EG--R------------------------------------------------------------------D-----E-PLRIGSAKSN-FGHLECAAGVVSLVKAALMLKHRKLVPSIN-FR-Q------PATPL--FSGWNVQVQT--KVE-DFPE--G------Q-HMIGVNNYG-FGGALAHAVLKEAP----------------------------------------------------------------------------------------------------- 112 ------------------------IAVVGVGGRFP-G-A---KDVDQFWRLLL-NKENHV-KDI-PP--D-RW-NNDA--FYD----ANPDVPGKT-YVKKAGLL-----D-D--HD-VFDNRLFGINDL-EAERMDPQQHYVLECTHMALENAGITR--------AKIAG--SRTGVYI---------------------------------------G-AMNQDF--GGAG-QH-----------D----V-YL-SSNNYSVTGASSSILAARVSYVYDLRGPA------MVVDTACSSSLVALHLGSQAIAAGECDMAICGGVSGLLLP-DFFIVLSRARMLSPSGQSQAFSQTAD--------------------------------------------------------------------GYARGEGCGVVILKRLG-QAVR----------------DGDHIWG-VVLGTLCN--QDGRTAT-------P---LTSPSGAQQVNLLRDVYSK-F-KVNP-RDVTYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEVNALG-QFFG-ST--D------------------------------------------------------------------R-----P-PLPIGSVKTN-IGHLEPAAGMAGLIKVFLMIRHQKYVPTVL-FS-----E--LNAQLD-FVGYRFHVCR--DVT-EWKV--S-P--G-HARTACVNSFG-FGGTNSHAIVQEY------------------------------------------------------------------------------------------------------ 113 ------------------------IAIIGIGCRFP-G-A---SCLSEFWQVLV-KGENHV-VEIS-D--E-RW-RRDI--YYD----KDPRAPGKA-YAPRAGFI-----E-N--YA-HFDFKMFGINEQ-EAAQMDPQQRQVLECTYMALEDAGITR--------QQIAG--QKVGVYI---------------------------------------G-CMNNDF--TQMS-NK-----------H----P--Y-LVDNYTVTGTAVSVVSNRVSYIFDLRGPS------MTIDTACSSSIVALHQAALAMKAGDCSMAICGGVNLLLNG-GLFVPLSKAQMLSPTGQCHTFSDKAD--------------------------------------------------------------------GYTRGEGCGIVIIKSLK-Q--------------A--MKDGNNIWG-TIA-TGLN--QDGHVAK-------P---LTAPSGEQQAQLIQDVYSK-H-GINP-ASIDYIEAHG-----------------------------------------------------------------------T-GTKI------G------DPVEVTAFG-HFFL-KQ--QQ-S--K------------------------------------------------------------T--------RYMGSVKTN-IGHLESAAGVAGLIKVLLMMKHNTIVPSLH-FD-RP------NEAIE-FDRFQFVVPT--KPV-PWLP--D-------QKVACLNSFG-FGGANSHAIVKS------------------------------------------------------------------------------------------------------- 114 -------------------------AIVGIGCKVP-G-A---ENIREFWRLLL-KGENHI-VEIP-S--T-RW-NAEA--CYD----SDPLAPGKS-YVMRAGLV-----S-G--PD-EFDNKLYSINDF-EAGEMDPQQRFVLDCTIMAMEDAGITR--------AQLAG--SNTGVFM---------------------------------------G-VMNSDH--RTLF-TA-----------Q----C--S-TISNYTVTGISNTVIAARVSYVLDLRGPC------LVLDTACSSSLVAIHLGCQAIRTGDCDVAICGGVNYFGLP-DVFVHLSKARMISPSGQCHSFSHRAD--------------------------------------------------------------------GYTRGEGCGVVILKRLR-D--------------A--LRDGDNIWA-TIY-TGVN--QDGHSVA-------P---ITAPSGLQQIRLLEHIYNN-L-DIDV-SAIDYIEAHG-----------------------------------------------------------------------T-GTVA------G------DPVEVNSLG-EFFT-GS---T----T------------------------------------------------------------P-----R-TRYIGSVKTN-IGHLESAAGVVGIIKVLLMMKNQKIVPSLH-CD-----V--PNPKIR-FDDFLLKVPK--EVV-DWSN--P-------VKMACCNSFG-FGGSNGHALLR-------------------------------------------------------------------------------------------------------- 115 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNGDCDTAICGGVNYIADP-GMFVQLSKTQMISPNGQSKAFSAEAD--------------------------------------------------------------------GYTRGEGCGIVVLKRLK-D--------------A--QKINDRIWA-TVV-SGVN--QDGHTVT-------P---MNAPSGSQQEKLMSDIYTK-Y-NVNV-SRLDYIEAHG-----------------------------------------------------------------------T-GTQA------G------DPVEVNALG-KFFT-MM---G----Q------------------------------------------------------------P-----R-TRYIGSVKTN-IGHLEAAAGVIGVIKVLLMMKHDTIVPSLH-C---Q--K--VNPLID-LEKLRFAVPQ--SLV-KWES--K-------EKMACCNSFG-FGGTNSHVVLQT------------------------------------------------------------------------------------------------------- 116 ------------------------IVVIGIGCRTP-G-A---DNTQEFWELLK-RGECMI-TDVP-P--G-RW-NAAA--YLDT--DSSTRAFGKA-YVQKGGFV-----K-D--IY-GFDNVLYDIKEL-EAIQMDPQQRMLLDCTYMAMQDAGITR--------TDIWQ--TNTGVFV---------------------------------------G-CMNDDH--ATSY-AA-----------S----T--S-KTSSVSATGCATSVLAGRLSYVFNLLGPS------MMIDTACSSSLMAFHLACQAIRAGECDMAICGGVNCMILP-EMYVQLCKAGMLSPTGLCHTFSDQAD--------------------------------------------------------------------GYTRGEGCGVVILRWLK-D--------------A--LRDGNNILA-TVVGTGTN--QDGRTATTDDGRTAP---ISAPSGSQQVKLLTSVYRK-A-GVDV-SRLDYIEAHG-----------------------------------------------------------------------T-GTPT------G------DPVEVKALG-EFLR-TE---G----G------------------------------------------------------------P-----R-DRYIGSLKTN-IGHTESAAGILSVIKLVLMMKHNMIVPSLH-C---H--V--VNPKID-LAELRFSIPK--QTI-PWSN--P-------LKLVGCNGFG-VGGSNCHAILSS------------------------------------------------------------------------------------------------------- 117 ------------------------IVVIGIGCRTP-G-A---DNTQEFWELLK-RGECMI-TDVP-P--G-RW-NAAA--YLDT--DSSTRAFGKA-YVQKGGFV-----K-D--IY-GFDNVLYDIKEL-EAIQMDPQQRMLLDCTYMAMQDAGITR--------TDIWQ--TNTGVFV---------------------------------------G-CMNDDH--ATSY-AA-----------S----T--S-KTSSVSATGCATSVLAGRLSYVFNLLGPS------MMIDTACSSSLMAFHLACQAIRAGECDMAICGGVNCMILP-EMYVQLCKAGMLSPTGLCHTFSDQAD--------------------------------------------------------------------GYTRGEGCGVVILRWLK-D--------------A--LRDGNNILA-TVVGTGTN--QDGRTATTDDGRTAP---ISAPSGSQQVKLLTSVYRK-A-GVDV-TRLDYIEAHG-----------------------------------------------------------------------T-GTPT------G------DPVEVKALG-EFLR-TE---G----G------------------------------------------------------------P-----R-DRYIGSLKTN-IGHTESAAGILSVIKLVLMMKHNMIAPSLH-C---N--V--VNPKIN-LTDCRLIIPK--QAV-PWPN--K-------EKLAGCSGYG-VGGSNCHVALASY------------------------------------------------------------------------------------------------------ 118 ------------------------IAIVGIGCRFP-G-A---TCLEEFWDILA-KGENHV-VDIP-P--E-RW-NKDA--FYD----SDVNAVGKS-YSMKAGLL-----K-N--FD-NFDNKLFKINET-EAAQMDPQQRQVLECTYMALEDAGITR--------QQIAG--QKVGVYI---------------------------------------G-SMTVDY--GDLI-ST-----------K----S--Q-DVTNHTVTGQARAIISNRVSYVFNLTGPS------MTIDTACSSSIVALHQAGLALRAGDCSIAICGGVNMLIHP-AYFIKLSKAQMLSPTGQCHAFSANAD--------------------------------------------------------------------GYTRGEGCGVIIVKLLS-Q--------------A--LQDGDNIWG-TIV-TGLN--QDGHQVT-------P---ITAPSGKQQQELLNDIYTR-H-GIDP-TEVDYIEAHG-----------------------------------------------------------------------T-GTKR------G------DPVEASALG-TFFE-KY--PR-Q------------------------------------------------------------------------RHIGSVKTN-IGHLEAAAGVAGLIKVLLMMKHDTIVPSLH-FD-KP------NEEID-FDRFQFVVPT--KTS-DWKR--H-------KKIASVNSFG-FGGSNSHAVLTSF------------------------------------------------------------------------------------------------------ 119 ------------------------IAIVGIGCKVP-G-A---DNVEQYWKVLE-RGENHV-IDIP-K--D-RW-NNDA--FYD----PDPHAIGKS-YVRRAGLL-----K-D--PI-AFDNKLFNINDF-ESDQMDPQQRYVLECSFMAMEDAGITR--------EKLAG--SNTGVYV---------------------------------------G-AMNGDY--RGLF-TA-----------K----S--S-IVGNYTVTGISNSIIAARVSFVFDLRGPS------MTLDTACSSALLAIHIGAQALRTGDCDIALCGGTNFLMAP-DVFVHLSKAHMVSPTGQCFAFSDSAD--------------------------------------------------------------------GYTRGEGCGMVILKRLN-D--------------A--LRDGDRVWA-TID-TGSN--QDGHSVT-------P---ISAPSGDQQIKLLEQVYRN-A-KIDV-NHIDYIEAHG-----------------------------------------------------------------------T-GTSA------G------DPVEANALG-KFFQ-EK---G----A------------------------------------------------------------V-----R-HRYIGSVKTN-LGHLESAAGTAGLIKVLLMMKHSKIVPSLF-FD-----N--PNPKIN-FPEMNLSVPT--KVV-DWPT--Q-------NKVACVNSFG-FGGTNCHAVVQAY------------------------------------------------------------------------------------------------------ 120 ------------------------IVIAGISGRFP-E-S---ASVREFEENLY-SKTNMV-TM---TGR--RW-EYG-------------Y-L--G-TPPYMGTLK--------NISH-FDTEFFGVSGK-QADVTDPQIRIMMEVVYEAIVDAGESF--------ASLKGS--RTGVYV---------------------------------------G-ITCSEP--QDAW-MK---D-----------------GVDPYIIPGTNHCMVANRINFFFDLRGP--------------------------------------------------------------------------SCAYESACSTSIVTLEAADMHMRSGLIDSAIVAAVNLCCRPVTSQVFAGMNFTTDD--FCKTFDVKGDGFVRAEAVSAVFITKKE-M--------------A--KR----IYG-TICGTSTN--NDGFNPN-------G---IMFPNFVAQEELMKDIYHN-N-VIDM-NKINYFETHG-----------------------------------------------------------------------T-GTPA------------GDPQECKAIC-NAIC-K--K---R----------------------------------------------------------------N----K-PLLIGSVKTN-CGHAETASGMCSLTKIVLAMHKDLVPANLH-Y---D--T--PNPAITGLFDGSLKVCD--EHT-KLGG-----------GYISLNSFG-IGGTNGHCLIK-------------------------------------------------------------------------------------------------------- 121 ------------------------IAITGISGRFP-E-C---KSVTELKENLY-NKVNMI-TE---DNR--RW-EIG-------------Y-M--G-TPSVMGKIK--------DVEK-FDAEFFGINSR-QANSLDPMLRKFLETAYEAIVDAGESL--------QSIKGT--RTGVYL---------------------------------------A-VSQLEA--EAAY-YG---------------------NQEPYALLGCPHSTLPNRVSFVFDIRGP--------------------------------------------------------------------------SVAYDTACSSSLTCMEAAERHIRDGVVDQAIVGGANFCLRPSTSVAFGSMSMLSNS--ACKTFDASGAGFVRGEVAGSLLLQKVK-D--------------A--KR----IYA-TTLGTLVN--NDGFTPD-------G---ITFPNRFGQEELMRDVYLN-F-KIDP-NDVKYFEAHG-----------------------------------------------------------------------T-GTQA------------GDPEETAGIC-AALC-GK-G---R----------------------------------------------------------------Q----G-PLLIGSIKSN-IGHGETAAGIASITKVVLACNTGVIAPNLH-Y---N--T--PNPKITGLFDGSLKVVD--EAT-PLDR----------NGLVAINSFG-LTGSNGHTVLRP------------------------------------------------------------------------------------------------------- 122 ------------------------IVIAGISGRFP-E-S---ASVREFEENLY-SKTNMV-TK---TGR--RW-EYG-------------Y-L--G-TPPYMGTLK--------NLSH-FDTEFFGVSGK-QADVTDPQIRILMEVVYEAIVDAGESF--------ASLKGS--RTGVYV---------------------------------------G-ITCGEP--QDAW-MK---D-----------------GVDPYVIPGTNHCMVANRINFFFDLRGP--------------------------------------------------------------------------SCAYDSACSTSIVTLEAADIHMRSGLIDSAIVAAVNLCCRPVSSQAFAGMNFTTDD--FCKTFDVKGDGFVRAEAVSAVFLTKKE-M--------------A--KR----IYG-TICGTSTN--NDGFNPN-------G---ILFPNFVAQEELMKDIYHN-N-VIDM-NKINYFETHG-----------------------------------------------------------------------T-GTPA------------GDPQECKAIC-NAIC-K--K---R----------------------------------------------------------------N----K-PLLIGSVKTN-CGHAETASGMCSLTKIVLAMHKDLVPANLH-Y---D--T--PNPAITGLFDGSLKVCD--EHT-KLGG-----------GYISLNSFG-MGGTNGHCLIK-------------------------------------------------------------------------------------------------------- 123 ------------------------iviagissrmp-d-s---anideftenlf-nkkhmv-tt---teaagry-eng-------------l-r--d-apmylgaip--------dadk-ydttffgmyps-mafacdpqsrmllerayeavidagesw--------dslrgs--rtgvfi---------------------------------------g-gypsds--secg-rt----------------e--e-rmngytfigythchlanrisfffdfkga------s--------------------------------------------------------------------fstdcgdgsglcaleiamthirlgnidraivgstnivqdinstvaganvgfysfd-gkcrafdanasghcradasvvlllskkd-r--------------a--kr----syc-svlhvrns--gdgytee-------g---fkaksseaqskllqniyte-m-gidp-nkisfveahg-----------------------------------------------------------------------a-cnle------------ddkieadala-dvlctn------r---------------------------------------------------------------k-----s-pllvgsvntn-mghadgsaamaglvksliacerrmippslh-f---e--t--pnpnikalfdgrikilt--eaa-pfek-----------glisinsfg-vgctnyhati--------------------------------------------------------------------------------------------------------- 124 ------------------------iaivgigckvp-g-a---dnveqywkvle-rgenhv-ieip-k--e-rw-nnda--fyd----tdphaigks-yvrkagll-----k-d--pi-afdnklfnindf-eadqmdpqqrfvlecsfmamedagitr--------dklag--sntgvyv---------------------------------------g-amngdy--rglf-ta-----------k----s--p-vvgnytvtgisnsiiaarvsftfdlrgps------mtldtacssallaihigaqalrsgdcdmalcggtnflmsp-dvfvhlskahmvsptgqcfafsdsad--------------------------------------------------------------------gytrgegcgmvilkrlk-d--------------a--lkdgdrvwa-tie-tgsn--qdghsvt-------p---isapsgdqqikllqhvykn-a-qvdl-nridyieahg-----------------------------------------------------------------------t-gtsa------g------dpveanalg-kffq-dn---g----a------------------------------------------------------------i-----r-hryigsvktn-lghlesaagtaglmkvllmmkhskivpslf-fd-----r--pnpkid-fpnmnltvpt--evv-dwpt--q-------nkiacvnsfg-fggtnchalvmay------------------------------------------------------------------------------------------------------ 125 ------------------------vaisgisgrlp-e-s--d-nlaefrenlm-nkvdmv-te---ddr--rw-ev-------------gl-h--g-lpprmgkvk--------elrh-fdagffgvhpk-qadcmdpqlrmllevtyeaiidagqsi--------esvrgs--rtgvfi---------------------------------------g-vslsda--adaw-tq---d------------a--e-nlvgyampgccramfanrvsfffdfkgp------s--------------------------------------------------------------------yaidtacsssmmgldqalqnirmgiidsavvggtnlclkantslqftrmgmtspd-gacktfdasgdgycrseavsaiflqkta-d--------------c--rr----iya-tvlhsktn--sdgykeq-------g---itfpsgilqkrlinevyhe-i-ginp-ldiaymeahg-----------------------------------------------------------------------t-gtkv------------gdpqeinsiv-dvfc-k--g---k----------------------------------------------------------------k----e-plligstksn-mghpeaasgltsiakiiiameeriippnlh-y---k--n--pnpdipgltdgslqvit--ect-rwng-----------glvamnsfg-fggsnvhavyr-------------------------------------------------------------------------------------------------------- 126 ------------------------VAISGISGRLP-E-S--N-NIQEFRDHLM-NKEDMV-TT---DDR--RW-TV-------------GL-H--G-CPPRNGKVP--------EITK-FDAGFFGVHPK-QTDCMDPQLRMLLEAAYEAIIDSGQSM--------ESVRGS--RTGVYI---------------------------------------G-VSLSDS--SDAW-TM---E------------T--D-GMVGYTMPGCCRAMFANRISFFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALMGIRTGLIDSALVGGSNLCLKPNTSLQFVRMGMTSPD-GACKTFDASANGYCRSEAIMAMFLQKVP-D--------------S--KR----LYA-TVVHTKSN--CDGYKEQ-------G---ITFPSGDLQQRLIREVYDE-I-GINP-SEINYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINSIV-DVFC-E--N---R----------------------------------------------------------------T----G-PLLIGSTKSN-MGHPEAASGLTSIAKILISMEEKMLPPNLH-Y---N--N--PNPEIPGLTDGSLKVVT--ECT-KWDG-----------GLVAMNSFG-FGGANVHAIYKSN------------------------------------------------------------------------------------------------------ 127 ------------------------IAIAGISGRYP-E-S---DSVGEFRDNLF-GKVNML-TC---DDR--RW-KLG-------------H-L--D-LPDVLGKLR--------SVDR-FDSEFFNLNSK-QTEMLDPQTRLLLEVCYEAIVDAGESL--------ASVKGS--RTGMYL---------------------------------------A-ISSSEP--EQAW-IC---R------------------QDPYIVMGCPHTMSPNRISFFFDLHGP------SIAYDTACSSVLVALEAAFQHMRTGVIDSAIVAGVNTCFRA-LTSKVYQNMGMLGPE-A--------------------------------------------------------------------CKAFDSSGNGYARSEIVSALFLKKSS-D--------------S--KR----IYC-SVVNVKTN--NDGFTPQ-------G---LTFPSGEIQEQLMRNVYAD-C-KLNP-KEVSYFECHG-----------------------------------------------------------------------T-GTPA------------GDPQETNAIY-RVMCTP--D---K----------------------------------------------------------------R----E-PLLIGSVKSN-MGHAETGSAMASITKVILAMHEGFIAPNLH-F---R--S--PNPKIEGLRDGKMAVVT--EAT-PWS-----------GGYMAINSFG-MGGSNAHAVLRSY--D--VS--S-S------K----PHP--SA-H-------------------------K------PRLFTYSARTEHGLRAIL-------------------- 128 ------------------------VAICGLSGRYP-E-S---ANVGELEYNLF-NKIDMV-TI---DNR--RW-EPG-------------Y-L--G-TPERMGKVK--------TITD-FDAEFFGVHTK-GAQTMDPMLRNLLEVVYEAIVDAGESL--------ESMKGT--RTGVYI---------------------------------------G-VSNNEV--DTAY-MK---N------------W--T-DDDAYMVQGCHHSMYPNWISFFFDFSGP--------------------------------------------------------------------------STAYNTACSTSLVCLDAAERHLRMGVIDNAIVGGSNFIYRPATTKLFMGMNFLGSS--TCKAFDESGDGFVRGEVASAILLKKAD-T--------------A--KR----VYC-TLVGSMLN--NDGNQTN-------G---ILYPNSEAQEQLMTDIYST-H-KIDA-NEVKYFECHG-----------------------------------------------------------------------T-GTQA------------GDPNETRAIC-NAVC-K--G---K----------------------------------------------------------------K----D-PLLIGSIKSN-LGHGETASGINGISKVIITMHSRQIPPNLH-F---K--N--PNPKIPGLFDGRLKVVT--ETT-PFD-----------GGLIAINSFG-MGGTNAHAIFRSF--D--KR--A--------E----PHP--AS-D-------------------------K------PRLFTYCARTEEGLQKIF-------------------- 129 ------------------------VAISGISGRLP-E-S--D-NMAEFRDHLM-KKEDMV-TA---DNR--RW-EI-------------GL-H--G-NPPRNGKLK--------EIRH-FDAAFFGVHPK-QADCMDPQLRLLLEVAYEAITDAGQTI--------ESVRGT--KTGVYV---------------------------------------G-VSQSDA--SDAW-SA---D------------A--E-TLVGYTMPGCCRAMFANRISFFFDLKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALHSIRMGIIDAAIVAGSNLCLKPNTSLQFVRMGMTSPD-GACKTFDASGDGYCRSEAVMAIYLQKTS-D--------------C--KR----IYA-TVVHAKSN--SDGYKEQ-------G---ITFPSGIMQKQLIDEVYHE-I-GVSP-VDVAYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQETNSIA-DVFC-K--G---R----------------------------------------------------------------K----G-PLLIGSTKSN-MGHPEAASGLSSIAKILIAYEERVIPPNLH-Y---K--N--PNPEIPGLIDGSLQVVT--ECT-RWNG-----------GYVAMNSFG-FGGANVHALYRSH--D--KE--L-L------E----PHI--AS-D-------------------------K------PRLFTCNARTEAGVKVLL-------------------- 130 ------------------------IVIVGVGCKFP-G-A---NNLKEYWRVLK-KGENHV-KEIP-K--E-RW-NNDA--FYD----PDPDAPGKS-YVRKAGFI-----Q-G--ID-EWDHRSYGINDI-EAELVDPQQRLVLDCVQMALEDGGITK--------ATIEK--TNTAVYI---------------------------------------G-SMTDDY--RSHV-M------------D----N--T-TASTYSVTGTHRSIISARVSYVYNLLGPA------LTIDSACSSSLVAIDIASHAIATGRCTTAICGGVNVLLDP-QMFVALCKARMLSPTGQCQTFTAHAD--------------------------------------------------------------------GYARGEGCGIVILKTFK-D--------------A--LRDGNKIWG-TIK-TGTN--QDGTMAK-------P---ITAPAEEQQKNLIEELYKR-V-NVSK-SSISLIEAHG-----------------------------------------------------------------------T-GTPL------G------DPTEVSALG-AQFG-RS--T-NA---------------------------------------------------------------P-----S-NVYIGSVKTN-IGHLEAAAGVAGLIKVLLMMKYETVVPSLW-YS-KE--N--ENPKLN-LSALGLSVPT--ESV-PWTV--P---SE-KGMVACVNSFG-FGGTNAHAIIEQFT----DS--K------N-Q---S-Q------------------IT-TANQ--R------------------------------------------------L 131 ------------------------IAIIGIGCRVP-G-A---DNIDEFWRVLV-NGENHI-VDIP-P--E-RW-NNDH--FYS----DH-GEPGTT-FVKKAGLI-----K-G--HD-EWDYEFFRVSKG-EAETIDPQQRLVLECAHMAFEDGGITR--------GQLNG--TRTGVFI---------------------------------------G-AMNDDY--KGMS-ND-----------D----H--E-EETNYSATGMSSTYISARVSHVYNLHGPC------TTLDTACSSATMAIHLGCQSIRAGESSMAVCGGVNIILGP-DQFIVLCKARMLSPTGQCQTFCDSAD--------------------------------------------------------------------GYVRGEGCGIVILKSYK-L--------------A--VQDGNKIWG-LIK-TGTN--QDGRTAL-------S---MAAPSDDQQLELLKNMYKH-Y-DIDP-TSLQYIEAHG-----------------------------------------------------------------------T-GTAV------G------DPIETAALG-KFIN-L--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-------------------- 132 ------------------------VVVSGISCRLP-Q-A--D-NMEEFKDNLM-EGVDMV-TE---DDT--RW-TPGT--------------Y--G-LPKRSGKLK--------DLSK-FDASFFGVHPK-QANSMDPQLRLLLEVTYESLIDAGVNP--------DMVQGS--NTGVFI---------------------------------------G-ASASES--HDAW-SI---E------------P--E-STVGYAMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------YTIDTACSSSLLALDQALHSIRSGQCEAAIVGGANLCLKPAVAVQFMKLGMLSPD-GMCKSFDAEGNGYCRSEGIVAIYLQREP-S--------------A--KR----IYC-NLVHSKTN--SDGNKQQ-------G---ITFPSGEIQKRLLHEVYSE-A-CIDP-TKVTYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIS-DVFC-K--D---R----------------------------------------------------------------N----T-PLLIGSVKSN-MGHSEPASGLAAVAKVIVAMEEGTLPSNLH-Y---K--S--PNTDIPGLSNGQLQVVN--QNT-DWDG-----------GVVGVNSFG-FGGSNVHSILRSN----GNS--N-K----T-S----PCD--GC-E-------------------------K------KRLFNYCSRTEQGLKDT--L------------------ 133 ------------------------IVISGISCRLP-E-S--E-NMEEFKKHLM-KGDNMV-TE----NR--RW-EPGS--------------H--G-LPAKSGTLM--------DISK-FDAAFFGVPPK-LVDNMDPQLRIMLELTHEALIDSGISP--------MTIRGT--NTAVYV---------------------------------------G-CGLSET--WEAL-ST---D------------D--S-NVTGYSPLGCTTSMFANRISFAFDLKGP------S--------------------------------------------------------------------YGLRNGCASGLLALDRAVASIRNGDCDTAIVAGCNLCLKPAASVQLAEMNLLSSD-GQCRCFDESVDGYGRSEGVVVMCLQRKT-N--------------A--KR----IYC-TVIHSKSS--TFITDND-------H---MNYPSFEEERKFLQDTYKE-A-RLDP-SHVTYIEANS-----------------------------------------------------------------------S-CSKI------------ADASEINAIA-DVLC-R--N---K----------------------------------------------------------------T----K-PLLIGSVKSN-IGHTEATSGLASVSKIVIAMEDGVIPPNIN-Y---K--L--PN-----IQNGQIKVVE--ERT-RLNG-----------DYCSVNSFG-LGGANVHTIFKSF--T-DKN--N--------K----YHF--AN-E-------------------------K------KRLCIYSARTKPALESIF-------------------- 134 ------------------------VVISGISGRLP-E-S--D-NLEEFRQHLM-KGEDMV-TE---DDR--RW-KPGL--------------Y--G-LPKGNGKLK--------DLSK-FDATFFGVSPK-QADAMDPQLRLLLETAYESIVDAGVDP--------QSLRGT--KTGVFI---------------------------------------G-ASFSES--AEAW-AS---G------------M--S-KTLGYSMTGCARSMFANRLSFFFDLKGP------S--------------------------------------------------------------------YVVDTACSSSLLALDSALHSIRNGHCDAAIVGGSGLILKPASSLQFMQLGMLSPG-GRCKSFDASGDGYCRSETVGCLFLQKAE-D--------------A--KR----VYA-TVVHSRNN--CDGHKEQ-------G---ITFPSGEVQKLLLQQIYAE-A-GVEP-SCVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIT-DVFC-K--G---R----------------------------------------------------------------Q----G-PLFIGSTKSN-MGHPEPASGMAALSKLVIAMEDGVIPPNLH-Y---E--E--PNPDIPGLLDGRLAVVT--KCQ-PWTG-----------GYAGINSFG-FGGSNVHTLLQSN--H--KE--R-G----E-M----PHP--EA-I-------------------------I------PRLVTYCGRSKEGVQQVL-------------------- 135 ------------------------IAIVGVGCITP-G-A---DNLEEFWRLLV-KGENHV-VDIP-P--E-RW-NANA--YYS----PDTMTLGKS-YIRRAGLI-----R-A--PD-EWDNRLFGINDF-EANQTDPQQRLVLDCTHMALENAGLTK--------QKLQG--SNTGVYV---------------------------------------G-SMNSDY--RGLF-TA-----------A----S--T-IVGSYTATGISNSIISARLSYVYDLRGPS------MTIDTACSSALVSVHLGAQAIRTGDCDMAICGGTNYLTLP-DVFVHLSKAHMLSPTGQCHAFSGNAD--------------------------------------------------------------------GYTRGEGCGMLVLKRLR-D--------------A--ERDGDHIWA-TVI-TGSN--QDGRTVT-------P---MTAPSMSQQAKLLEKIYSH-P-AVDI-NKVDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPIEANAIG-NFFR-DN---S-R--TP-----------------------------------------------------------G-----R-IRYIGTVKSN-LGHLESAAGAVGVIKVLLMMRHSVIVPSLH-FS-ED--N--PNPRID-FEALQLMVPT--QVI-EWSA--K-------DKVACASCFG-FGGTNSHAVLMEYT----RK--P-C------P--------------------------------------------------------------Q-------------------- 136 ------------------------VVISGISCRLP-E-S--D-NMEEFRQHLM-KGEDMV-TE---DNR--RW-EPGF--------------L--G-LPRRNGKLK--------DLTK-FDAAFFGVSPK-QADCMDPQLRLLLETTFEALVDAGVDP--------LE-RGR--RTGVFI---------------------------------------G-VSASEA--SEAW-TA---N------------P--E-KTQGYMMTGCCRAMFANRLSFYFDFKGP------S--------------------------------------------------------------------YAVDTACSSSLLAMDHALQNIRTGQCDSAIVGGANLCLKPNTSLQFLKLGMLSPD-GACKSFDASGNGYCRSEGIVVIYLQKAK-D--------------A--KR----IYT-TIVHSKSN--CDGAKDQ-------G---ITFPSGKIQGQLLRELYQE-A-GLEP-ALVSYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIA-EVFC-A--K---R----------------------------------------------------------------S----S-PLLVGSTKSN-MGHPEPASGLSSMAKVVIAMEDGLIPPNLH-F---K--E--PNPDIPALTDGRIQVVT--EKT-PWQG-----------GYMAINSFG-FGGANVHTVLRSN----GKT--S--------A----PHM--GN-H-------------------------A------KRLFLYSGRTEQGLKQVL-------------------- 137 ------------------------IAITGLGCKFP-G-A---SNADQFWKVLR-DGENHV-IDIP-N--N-RW-FHDA--VYD----EDVHKPART-HARKAGLL-----Q-D--HL-AFDNKLFNIRDV-EADKMDPQQKYVLECTHMALENAGISR--------DQIKG--SKTNVYI---------------------------------------G-AMNTDY--RSEF-NY-----------T----S--T-MPDNFTVTGVSNSILSNRVAYVYDLRGEA------VTIDTACSSSLVAIKFGVQSLRAGDCDMVICGGSNSILTP-DTFIHLSKARMISAKGQCFAFSDQVD--------------------------------------------------------------------GYTRGEGCGIIILKRLQ-D--------------A--KRDNNKIWA-TIE-VGCN--QDGGTVA-------P---ITKPSEEQQTRLLEEMYSK-S-RIDP-NRLDYIEAHG-----------------------------------------------------------------------T-GTPV------G------DVVEVNALW-KFFQ-NS--K-----A------------------------------------------------------------E-----RH-RYMGSVKTN-IGHLESAAGVAGLIKVLLMMKHSKIVPSLH-FQ-HP------NPNID-FDGAKLTVPT--KLV-NWES--K-------NKVACVSSYG-FGGTNSHAVIESHD----EP--I-T------E---D-T----A-S-------------------------------------------------E-------------------- 138 ------------------------VAISGISGRLP-E-S--D-NLSEFREHLI-KKENMV-TA---DNR--RW-TV-------------GL-H--G-LPPRNGKVK--------ELRH-FDAGFFGVHPK-QANSMDPQLRILLEVSYEAIIDAGQSL--------ESVRGS--RTGVFI---------------------------------------G-VSQSEA--SDAW-TL---D------------A--E-TLVGYAMPGCCRAMFANRISYFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALMNIRMGIIDSALVGGTNLCLKPNNSLQFMRMGMTSPD-GTCKTFDAKGDGYCRSEAIMAIFLQKTA-D--------------C--RR----IYA-TVVHAKAN--CDGYKEQ-------G---ITFPSGDLQKALICEIYNE-I-GINP-LEISYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQETNSIV-DVFC-K--G---R----------------------------------------------------------------K----E-PLLIGSTKSN-MGHPEAASGLTSIAKIIIAMEDKVIPPNLH-Y---E--T--PNPDIPGLIDGSLKVVT--ECT-PWEG-----------GLVAMNSFG-FGGANVHTIFRSH--D--KE--L-T------E----PHV--AS-E-------------------------K------LRLFTCSARTEEGVKKIL-------------------- 139 ------------------------VVITGVSGRFP-GF----QNIEELVDDL-YKPQQGR-Y-------N---GRR-Q--Q-------------PT-P-TPNGQPI------F--DY-PFDYQFFGIDET-RVKSMDSGLRGLVEVTYEAIFDAGFNP--------TELKGSK--TGVFLG----------------------------------------GYGS--PSP-Y---H----------------K-QF-----DQPQWSTSSTYPVQLLNFFEFSGPY------GYVDTTISSGLVALDRAFLSICKGECEQAIVGGIH--------------------------------------------------------------------------------------------------------NGTVGVVFLQKTG-L--------------T--RR----FYAKIKT-TKTIQTPIGEKDF-------N---FAYQNGEEFGRYLREVYTE-N-NIDP-SLIQYVESHN------------------------------------------------------------------------PELQTTTSKPYN------ETNEYKLI-TDVFG-GR--Y--R---------------------------------------------------------------Q-----I-PLFVGSTKAY-GYHD---HGIVSLIKMLIAAQRGILPKTLK-LQ-----S--ST-------SGEYLPIQ--ETKT-FNGG-----------LMALNSFG-YPGASVHVVLQPNC----EQ--F-Q------R---K-FG--QQ-L-FW---NQNF-S---QYL------QQ------PRLFHWSATNEQGL------------------------ 140 --------------------------IGGLACRMPM--S---RNSKEFWENLI-KGKDMI-G-------SPHW-PQG---LYG--------------LPPRIGALQ------D--LE-NFDNGYFDISK-TEVGLMNPMLRHLLEVTHECIVDSGLKL--------TALQQT--KTGIYL---------------------------------------A-CFGSDT--DFT-ET---------------------AID-FQ-NYATTSPYLVGGLSKIFGLTGPA------VTMDTACSSSMAALNTAVNDLIAGKCTYAIVAACNMILNP-LFSQQMSVLGMLSKEGISSVFDEAAN--------------------------------------------------------------------GYVRAEACAAILLARDA-D---------------SFPR----VYCN-VIDIGIS--CDGYKKT-------G---ITNPNPETQAALMKELYE-R-SGVNV-KDIYYVEMHG-----------------------------------------------------------------------T-GTQV------G------DVAEAAGIT-EVFC-RD--R------------------------------------------------------------------D-----E-PLLIGSVKSN-MGHSEATSALASIIKVIMMMHFKEIPANLN-YK-----N--PNPGITGIHSNKLKVVD--KPV-PWKG----K-------YVGVSSFG-FGGVNGHAILEPYY----EK----------------------------------------------------------------------------------------------- 141 ------------------------IAIVGAGCRFP-G-A---DNLEEFWRLLL-NGENHV-KDIP-R--T-RW-NNDA--FYD----EDQTAPGKI-YVKKAGLL-----T-N--HD-KWDNRLFGISDV-ESGRVDPQQRYVLECVHMALEDGGITR--------GQING--TKTGVII---------------------------------------G-CMNDDY--KMMA-NS-----------D----L--T-EVGNFNATGTAPSVISARVSYVYNLHGTC------LTLDTACSSALIAIHLASQAIKTGDCDMVICGGVSSILSP-DTFTALCQARMMSKVGQCQSFCDTAD--------------------------------------------------------------------GYARGEGCGIVILKSLK-K--------------A--SEDGNKIWA-TIK-TGSN--QDGCTMK-------P---MTAPSAQQQEELFKNVYDV-H-GICP-DDIQYIETHG-----------------------------------------------------------------------T-GTPR------G------DPTEVNALG-KFFS-SF--RQ----NA--------------------------------------------------------K--------T-PLLIGSVKSN-IGHTESAAGVAGLLKVLLMMKHGKYVPSLH-VK-PDNSN--VNKS-------------------------------------------------------I------------------------------------------------------------------------------------------------------- 142 ------------------------IAIVGVGCRFP-G-A---ENLEEFWRVLV-NGENHV-DEIS-L--S-RW-NNEA--FFD----EDKTIPGKI-YVKKAGLL-----K-D--HD-KWDNRLFGIGDA-EASRLDPQQRYVLECVHMAMEDSGFTR--------QQLSG--TNTGVII---------------------------------------G-CMNDDY--KTIA-NS-----------D----L--A-EINTYNATGTSVSVISARVAYVYNLHGTC------LTLDTACSSALIAIHLASQAIRTGDCDMAICGGVSSILSP-DTFTALCQARMMSAVGQCQSFCDTAD--------------------------------------------------------------------GYARGEGCGIVILKRLQ-D--------------A--LKDNNKIWA-TIK-TGSN--QDGSTMK-------P---LTAPSGDQQFKLLSHVYET-H-GFCP-SKIQYIEAHG-----------------------------------------------------------------------T-GTPR------G------DPTEVNTLG-KFFS-EY--RS----NA--------------------------------------------------------N--C-----N-PLLIGSVKSN-IGHTESAAGVAGLIKILLMLKHGQYVPSLH-IK-PDKSN--VNKSIK-LSEYNIDIVT--GVM-EWEL--D-A--N-EERHACLNSFG-FGGSNTHAIISK------------------------------------------------------------------------------------------------------- 143 ----------------------------------------------QFKQNLM-NGVDMV-TE---DGR--RW-KPGL--------------Y--G-LPTRNGKLV--------DLSK-FDAAFFGVSPK-QADVMDPQLRMLLEVTYEAISDAGVDP--------TSVRGS--RTGVFV---------------------------------------G-ASASEF--HEAV-TT---D------------P--E-KTQGYCMTGCTRSMFANRLSFFFDFKGP------S--------------------------------------------------------------------HTVDTACSSSLLAMDQALQAIRTDQCDAAIVGGSSLVLKPLTSLQFQRLGMLSPE-GTCKSFDSEGNGYCRSEGVVVVYLQKEK-S--------------A--LR----MYS-RLIHSKTN--SDGGKDQ-------G---ITFPSGAIQKSLIQAVYSE-A-CVCP-STVAYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNTIT-DVFC-K--G---R----------------------------------------------------------------D----T-PLPIGSVKSN-MGHAEPASGLASVAKVIVSMEEGVLPANLY-Y---N--S--PNTDIPGLLDGRLQVVA--NNK-QWDG-----------GFVGVNSFG-FGGTNVHALLESN--T--KC--D-K------A----DNS--RN-E-------------------------C------SRVFVYSARTEDGVKSVM-------------------- 144 -----------------------------------------------------------------------------------------------------------------------WDFKVYGVNEF-EALKMDPQHKFVLDSTFMALENAGISK--------QQISG--SNTGVYI---------------------------------------G-MFSSDY--SNIF-ST-----------I----A--E-ESDNYTLTGTSNSIVAARVSYVFNLTGPS------MKIDTACSSSLVSIHLACQALRSGECDMAIAGGVNSLMKP-DIFIQLSKAGMVSPTGQCQAFSENAD--------------------------------------------------------------------GYARGEGCGIVILKPLE-K--------------A--LNDNDPIWA-TIV-TAVN--HDGQTVT-------P---ITTPSPQQQESLLDTVFDR-Y-RIDP-KSVDYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPVEVTALG-KFFH-----------------------------------------------------------------KN-KN--P-----K-ERLIGSVKTN-IGHLESGAGVAGLIKVLLMHKHQEIVPSLH-FD-----K--PSENVP-LEKYNLKVPT--KVQ-PWPK--ND---N-GYMRSCVNSFS-FGGTNSHAIITTPI----NP--S-N------E---P-DS--YY-TSIS--QLP-------------------------RIVCLSACDRTSLQMTK-------------------- 145 ------------------------VAIIGVGCRFP-G-A---DNVDEFWRVLR-NGENHV-IDVP-P--N-RW-NLEA--FYD----PDPTLAGKT-HVRRAGFV-----E-G--HD-KWDFKLYGVNEF-EARKMDPQHKFVLDGIFMALENAGISK--------QQTSG--SNTGVYI---------------------------------------G-MTTSDY--AKIF-ST-----------V----A--E-ESDNYTLTGTSNSIVAARVSYVFNWTGPS------MMIDTACSSSLVAVHLACQALRSGECDMAIAGGVNSLMTP-DIFIQLSKAGMISPTGKCQAFSENAD--------------------------------------------------------------------GYARGEGCGIIILKPLE-Q--------------A--LKDNDPIWG-TIV-TAVN--HDGQTVT-------P---ITAPSPQQQESLLDIVFDR-Y-RINP-ESVDYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPVEVTALG-KFFQ-----------------------------------------------------------------KD-TN--S-----K-QRLIGSVKTN-IGHLESGAGVAGLIKVLLMHKHR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 146 --------------------------IVGLAGRLPK--S---DNVQEFWNNLL-NKRDMI-G-------RTRW-PEG---LFE--------------MPPRAGIIN------N--VD-KFDADYFGFTE-SEAQSMNPLLRHMFEVCYECVVDSGLPV--------ELLQNN--TTGMYT---------------------------------------A-CFLPGH--DGL-EV---------------------SRW-ANSKYCTTVDQITGHVMRYLKLSGPM------ATVDTACSSALSALEMAVTDLELGRCHYALVAGCNLLLNP-AYIQMMMKLGMLNPTGQSNVFDANAG--------------------------------------------------------------------GYVRAEGIVAILLTRQQ-H---------------LCKR----IYAS-VVDIVTG--CDGFKEE-------G---ITFPSAKSQADMIKMLYK-R-AGVDV-NMVAYMEAHS-----------------------------------------------------------------------T-GTKA------G------DPVEVSAIA-ESLC-KE--R------------------------------------------------------------------K-----E-PLLVGSVKAN-MGHSEATAALASLVKCLLAARHGVIPPQIN-YN-----T--TNPKLTAVTEGKVVIVN--KPT-KLPD----G-------YIGLNSFG-FGGANGHLILKPYV----RT--S-K------Q---K-E--------EI----------------------Y------PMVVPVTARTDQELAS-I-------------------- 147 ------------------------IAIVGVGCQFP-G-A---NNLDEFWRLLV-NGENHV-NEIP-K--E-RW-NLDH--YYD----PNPDTPNKT-YVRRAGLI-----D-G--HD-EWDNRFYGISTA-EAEQIDPQQRLVMDCVHMALEDGGITK--------TKLNG--TYTGVYI---------------------------------------G-VMNDDY--RGAV-TG-----------D----G--D-HLDHYTLTGSSPSIASARVSYHYNLLGPA------ITIDTACSSALVAIHLAAQALKTGDCKMAICGGVNSILYP-EIFIPLSKARMVSPSGQCQAFSKNAN--------------------------------------------------------------------GYARGEGCGIVVLKPLS-M--------------A--LADNDHIWA-TVM-TGCN--QDGHTAT-------P---ITAPSVVMQGELLKKMYGQ-N-NIDP-KDIQYIEAHG-----------------------------------------------------------------------T-GTPT------G------DPVEATALG-QFFH-RE-----G--D------------------------------------------------------------------N-RIYVGSVKTN-IAHLESAAGSAGLVKVLLMMKNGKFVPSLH-VT-E------LNPAVP-FEKFGMKLVQ--EVF-DWDE--P-E--N-GSRMACVNCFG-FGGTNSHAILKQY------------------------------------------------------------------------------------------------------ 148 -------------------------VISGVSCRLP-E-S--D-NMEEFRQNLF-KGKDMV-TQ---TNR--RW-EPGY--------------S--G-IPKRSGTLK--------DISG-FDATYFGVHAK-QADATDPQLRIMLEVTYEAIVDSGIHP--------NSLKGT--DTGVFI---------------------------------------G-CGMSEA--LEAY-SS---D------------P--D-HSMSYTPLGCAASMLSNRLSYSFDLKGP------S--------------------------------------------------------------------YCLRNGCGSGLLALDRGVAAIRTGQCESVIVGGCNLCLKPSISLQLNKMGLLSPE-GICRCFDSEGDGYARSEGIVVFYLQKMT-E--------------A--KR----VYC-SILNTTCI--SYVSSSC-------K---STCPSFEEQMSMLDFAYKE-A-NVDP-ASLQYIEACS-----------------------------------------------------------------------P-CTKD------------GDVQEMEAVT-KVLC-N--N---R----------------------------------------------------------------Q----D-SLLIGCVKSN-IGHTEPVSGLAGIAKVILAMQDGMIPGNLH-Y---H--S--------------------------------------------------------------------------------------------------------------------------------------------------------------------- 149 ---------------------------------------------------------------------------VG---LYD--------------IPSRAGLIP------D--ID-KFDSYYFGYTE-TEAQNVNPMLWHLLEVTSECIIDSGLSL--------ETLQNN--MTGLYT---------------------------------------A-CFIPDF--DFI-ET---------------------SRC-ANSRLCTTASMISGHLKDHFRLVGPM------LTVDTACSSSLSALEMAVTDLQIGKCQYAIVTAVNLLLMP-NLFQQMTALGMLNPTGESNVFDANAG--------------------------------------------------------------------GYVRAEGVVSILLSRRF-D---------------TCKR----VYMK-IVDVKTN--TDGYKAD-------G---ITFPSSKSQAKLMREIYD-K-NGVDM-SQIVYFEAHS-----------------------------------------------------------------------T-GTKA------G------DPVEIAGIT-EAIC-SQ--R------------------------------------------------------------------I-----K-PLLVGSVKSN-MGHSEATAGLASLTKCILAARYGSIPSQLN-FN-----V--PNPKIESLTTGKVKIVD--EMM-PLED----G-------FIGLNSFG-------------------------------------------------------------------------------------------------------------------- 150 --------------------------VTGISCRLPQ--T---SNMTELWKNLI-EGVDMI-T--E-N--DLYW-PRG---THN--------------VPKRTGVLP------E--ID-RFDSLFFEINP-KQNKVYDFEHKLLLEVVHEAIIDSGYSP--------EELGGT--RCGVLV---------------------------------------G-SEGSSG--ATAEFYI----------------D--TAEINGFE-TKNHGSMMSNYISFFYDLKGPS------MTINSACSSSFQALRLAYRYMEDNQCDSMIVAGSHAQFSP-MANLTLTRAMMLANDGKCKVFDESAD--------------------------------------------------------------------GYVRSDGIVAILLQKAS-----------------VARR----IYAN-IRGVYDN--CDGRKSQ-------G---TSFPSAPSQKDLLRDFYK-T-TNMSP-DEVVYIETHG-----------------------------------------------------------------------T-GTQV------G------DKAEIAALS-EFFC-GN--G------------------------------------------------------------------R-----K-DLLIGSIKSN-LGHTEVTSGLASMCKVILAMQHKLIPGNLH-LT-----Q--FNSNIPELFDGSMKVIR--ENM-EWEA----G-------PTAINSFG-FGGAKVHCVIEPYK----EN--K-N------A---A-VK-------YD----------------------G------LRLATICGRTEESTKFF--L------------------ 151 ------------------------VVVSGISGRYP-E-S--E-NIKEFRDNLI-NKKDMV-TD---DDR--RW-PQGL--------------Y--G-LPTRSGKLK--------DISK-FDASFFGVSPK-QADNMDPQIRIMLEVCYEAIVDAGVNP--------ASVRGS--KTGVYV---------------------------------------G-TSASEA--HDAW-SN---D------------I--E-QMSGYVMSGCQRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------YTVDTACSSSLLAFNLAVDAIKSGQCDAALVSGCSLCLKPSTAVQFQRLGMLSSV-GCCKSFDESGSGYCRSESVVAVYLQKAD-T--------------A--RR----IYT-TVVHAKNN--ADGAKDQ-------G---ITFPSGAMQKQLLKEVYAE-A-RVDP-GSVSYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQELNTIA-DVFC-T--KS--R----------------------------------------------------------------R----G-PLLVGSTKSN-MGHPEPASGLAALSKIIISMQDGTVPPNLH-F---V--N--PNPDIPALQDGRLKVCT--ENT-PFNG-----------PYVAINSFG-FGG---------------------------------------------------------------------------------------------------------------- 152 ------------------------VVISGVSCRLP-Q-S--E-NMEEFKENLL-SGTDMV-TE---DDT--RW-KSGL--------------Y--G-LPKRSGKIK--------DLSK-FDASFFGVHPK-QANSMDPQLRMLLEVTYESIVDAGINP--------ETVRGS--KTGVFI---------------------------------------G-ASASES--HEAW-SM---E------------V--E-NTVGYAMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------YTIDTACSSSLLALDQALHSIRSGQCDAAVVGGANLCLKPAVAVQFMKLGMLSPE-GICKSFDAEGNGYCRSEGIIAIYLQKEA-S--------------A--KR----VYC-SLVHSKTN--SDGNKQQ-------G---ITFPSGEIQKQLLQEVYSE-A-CVDP-TQVSYIEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIC-DVFC-K--G---R----------------------------------------------------------------Q----G-PLPIGSVKSN-MGHAEPASGLAAVAKVIVAMEEGTIPSNLH-Y---S--S--PNPDIPGLTNGNLDVVS--RNK-KCDL-----------DFVGVNSFG-FGGSNVHTVLRAN----KNS--N------R-S----PCE--GC-E-------------------------K------KRLFLYSSRSEEGLRDT--L------------------ 153 ------------------------VAVIGIGCRFP-G-A---DNIEEFWKVLE-NGENHI-VDIP-P--E-RW-NNDA--FYS----EDQTEKGKL-YVKKAAFL-----N-H--YD-EWDNKLFGISDS-EASQVDPQQRYVLECVHMAMEDGGITR--------KQLNG--SPTGVYI---------------------------------------G-SMSSDY--KGMF-DF-----------D----H--E-SDTTYTATGGNNAIISARVSYVYNLQGPS------MVIDTACSSSMTSIHLGCQAIKTGDCDMAICGGVNSLLCP-DMFFIICRARMLSPDCQCQTFCDKAN--------------------------------------------------------------------GYVRGEGCGIVILKSYK-K--------------A--LEDGNKIWA-ILK-TRLN--QDGHAAQ-------P---ITAPSGEQQQKLLYQIYSH-Y-GIDP-TTLQYVECHG-----------------------------------------------------------------------T-GTQI------G------DAIEVNAIG-QFIM-SK--R---------HNSNSTGRD----V----NFGGKVHNDESNVFEENSSKQNPPIER----Q-YHLN--D-----Q-TILVGSVKTN-IGHLEAAAGVAGLIKVLLMMEKGKFVPSLH-VK-LDKSN--IKKTIK-FKEYALDVAV--DVT-SWYP--N-E--K-GERMSCVNSFG-FGGSNSHVIVIQ------------------------------------------------------------------------------------------------------- 154 ------------------------IAVVGIGCRFP-G-A---DNIEEFWRVLL-NGENHV-VDIP-S--E-RW-NTDA--FYS----DDRDEPEKI-YVRKAALL-----K-R--FD-EWDNEFFGVSGK-EAEQMDPQQRFVLECTHMAMEDGGITR--------KELDG--SLTGVYI---------------------------------------G-AMGSDY--RSMF-EA-----------D----H--S-EDTNYIVTGTSTTIIASRVSYVYNLQGPC------MIVDSACSASMIAIHLGCQAIRTGDCEMAVCGGVSTLLSP-DPFQGTCRAKMLSPTCQCQSFCETAD--------------------------------------------------------------------GYVRGEGCGIIFLKLYE-K--------------A--VQDGNKIWG-IIK-TGTN--QDGHMAQ-------P---ITAPAGNQQEKLLRKIYDQ-Y-GVNP-TALHYIECHG-----------------------------------------------------------------------T-GTPV------G------DPIEVNAIG-EFIS-SY--Q---------ASSQSHEMS-V-------EELEKSHNTDSSLMQKDSNSKH-------------------------TILIGSVKTN-IGHLEPAAGVAGLIKVLLMMEHGKFVPSLH-VK-KDKSN--LNKKIK-FNQYCLDVSV--KIE-AWYP--N-T--D-GDRIACVNSFG-FGGSNAHAIVIQKS--------------------------------------------------------------------------------N-------------------- 155 ------------------------IAIVGVGCKFP-G-A---DNLQEYWRVLK-NGENHV-KEVP-R--D-RW-NIDA--FYD----PDRNVRGKM-YVRKAGFL-----D-S--IE-EWDHRFHGINDM-EAELVDPQQRIVLDCVHMALEDGGITR--------NDING--TQTGVYI---------------------------------------G-SMTDDY--KGQV-MN-----------D----N--T-ISSTYSVTGTHNSIISARVSYIYNLFGPS------MTLDTACSSSLVAIDIASQALLTGQCSMAICGGVNILLDP-QLFIALSKAGMLSPSGQCRTFTRDAD--------------------------------------------------------------------GYARGEGCGIVLLKSLK-N--------------A--VKYGNKIWG-TIK-TRTN--QDGKMAS-------P---ITAPSGLQQERLLQDIYEI-N-KIDK-SRVTVIEAHG-----------------------------------------------------------------------T-GTVI------G------DPTEIKALG-SHLG-KR--A-SA---------------------------------------------------------------P-----G-KVYIGSVKTN-IGHLEAAAGVAGLIKVLLMMKHNVIVPSLW-YT-EE--N--ENPKLK-LSEHGFVVPT--QCT-PWVR--S-S--T-EKRLCCVNSFG-FGGTNVHAIVEEFE----QS--A------D-I---G-Q------------------EM-SALS--SPYP-L------PFILTIS------------------------------A 156 -------------------------------------------------TQLS-N----------------S---FDL--FFS--------------------------------YD-EWDNKLFGISDS-EASQVDPQQRYVLECVHMAMEDGGITR--------KQLNG--SPTGVYI---------------------------------------G-SMSSDY--KGMF-DF-----------D----H--E-SDTTYTATGGNNAIISARVSYVYNLQGPS------MVIDTACSSSMTSIHLGCQAIKTGDCDMAICGGVNSLLCP-DMFFIICRARMLSPDCQCQTFCDKAN--------------------------------------------------------------------GYVRGEGCGIVILKSYK-K--------------A--LEDGNKIWA-ILK-TRLN--QDGHAAQ-------P---ITAPSGEQQQKLLYQIYSH-Y-GIDP-TTLQYVECHG-----------------------------------------------------------------------T-GTQI------G------DAIEVNAIG-QFIM-SK--R---------HNSNSTGRD----V----NFGGKVHNDESNVFEENSSKQNPPIER----Q-YHLN--D-----Q-TILVGSVKTN-IGHLEAAAGVAGLIKVLLMMEKGKFVPSLH-VK-LDKSN--IKKTIK-FKEYALDVAV--DVT-SWYP--N-E--K-GERMSCVNSFG-FGGSNSHVIV--------------------------------------------------------------------------------------------------------- 157 ------------------------IAIVGVGCKFP-G-A---DNLQEYWKVLK-NGENHV-KEVP-R--D-RW-NIDA--FYD----PDRNAPGKT-YVRTAGFL-----N-S--ID-EWDHRLYGINDM-EAELVDPQHRIVLDCVHMALEDGGITR--------SDIEG--TQTGVYI---------------------------------------G-SMTDDY--KAQV-MN-----------D----N--T-ISSTYSVTGTHNSIISARVSYVYNLSGLA------VTLDTACSSSLVAIDIASQALLTGKCSMAICGGVNILLDP-QLFIALSKAGMLSPSGQCKTFTKDAD--------------------------------------------------------------------GYARGEGCGVVLLKSLK-N--------------A--VKDGNKIWG-TIK-TGTN--QDGHRAV-------P---ITAPSGLQQERLIKEVYER-N-KVDK-AKITVIEAHG-----------------------------------------------------------------------T-GTAI------G------DPTEANALG-SHFG-IK--A-GS---------------------------------------------------------------P-----G-TVYIGSVKTN-IGHLEAAAGVAGLIKVLLMMKHNVIVPSLW-YT-NE--N--ENPKVK-LSKHGFVVPT--KCI-TWQR--S-G--T-DKRIACVNSFG-FGGTNAHAIIEEYE----QS--G------S-V---G-S------------------KT-ESAS--S--P-L------PYFITVS------------------------------A 158 ------------------------VVISGISCRLP-E-S--D-NMEEFRQHLM-MGEDMV-TE---DDR--RW-PPGL--------------Y--G-LPRRSGKLK--------DLSQ-FDASYFGVHPK-QANTMDPQLRLMLEVVHEAIVDSGVNP--------DTLRGS--RTGVFV---------------------------------------G-ASASES--HEAW-ST---D------------P--I-TTEGYSMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------FTLDTACSSSLLALDQALHSIRQGHCDAAVVSGCSLCLKPTTALQFLKLGMLSAE-GVCRSFDAEGNGYCRSEGVIAILMQKKS-S--------------A--RR----IYS-TVLHSKTN--SDGNKEQ-------G---ITFPSGHLQKRLLQEVYSE-A-CIDP-TKVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIA-DVFC-K--G---R----------------------------------------------------------------L----G-PLLIGSTKSN-MGHSEPASGLSAIAKVIISMEDGNVPANLH-Y---N--I--PNPGIPALTDGRLQVVT--ETT-PLLG-----------CIVGINSFG-FGGSNVHAVLKAE----RNK--E-E------A----THP--AS-K-------------------------C------RRLLVCPGRDKDGLEKVL-------------------- 159 ------------------------VVISGISGRLP-E-S--D-NIEEFRQHLV-LGEDMV-TE---DNR--RW-EPGT--------------H--G-LPRRNGKLK--------DISK-FDAAFFGVSPK-QADTMDPQQRLLLETAYECIVDAGVNP--------QSVKGT--KTGVFI---------------------------------------G-ASFSEA--AEAW-GS---D------------T--D-KIIGYAMTGCCRAMFANRISFFFDLKGP------S--------------------------------------------------------------------FTVDTACSSSLLAMDQALHSIRMGHCDAALVGGCGLLLKPSSSLQFLQLGMLSPE-GMCKSFDASGNGYCRSEAVVMVFLQKSA-D--------------A--KR----IYA-TVVHSGNN--ADGNKEQ-------G---ITFPSGDMQKLLLQQVYSE-A-CIDP-VRVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEINAIT-DVFC-K--G---R----------------------------------------------------------------Q----G-PLLIGSTKSN-MGHPEPASGLAAVAKVVIAMEDGMIPANLH-Y---R--E--PNPDIPGLMDGRLSVVA--QRT-RWNG-----------GYVGVNSFG-FGGSNVHAILKSN--D--KQ--R------T-V----SHP--NA-Q-------------------------N------CRLFTYAGRTEEGVRRVF-------------------- 160 ---------------------------------------------------------------------------------------------------------------------------------------MDPQQRFVLECTHMALEDAGITN--------SQISG--SKTGVYI---------------------------------------G-SMTSDY--RSQF-MA-----------L----T--S-HLDTYTATGISNCVLAARISFLYNLLGPS------MVVDTACSSSLIGIHLGCQSLQSGESDMAICGGVNYMASP-DMFVHLSKAHMISPTGQCHAFSANAD--------------------------------------------------------------------GYTRGEGCGIVVLKRLR-D--------------A--IRDRDKVWA-TIV-TGVN--QDGHTVT-------P---MTAPSSVQQRALMHQIYSR-Y-QVDP-NKVHYIEAHG-----------------------------------------------------------------------T-GTEA------G------DPVEANSLG-AFFK-EE---T----T------------------------------------------------------------P-----R-IRYIGSVKTN-IGHLESAAGVIGVIKVLLMMKHSIIVPSLH-C---E--V--VNPKIN-LKNLYLSVPQ--TTI-NWDQ--A-------EKVACCNSFG-IGGTNTHIVLKQY------------------------------------------------------------------------------------------------------ 161 -------------------------LIAGIACRLPK--S---SNLEEFWENLI-GSHDMI-D-------STRF-PEG---LEG--------------VPPRAGLIP------D--ID-KFDAGYFGISD-IEADNMNVMLRHLLEVTYECVVDSGLSE--------KTLQNN--ITGLYL---------------------------------------A-CFLPDT--DPI-ET---------------------TKY-SKSKLCTTTPLLTGHISSYFGWKGPA------VSVDTACSSSLSAMEMAETDLRTGRCHFAVVASVNVIINP-VYLQQMAILGMLNPTGESKVFDRDAG--------------------------------------------------------------------GYVRAEGVAAIILTRQE-A---------------LCKR----IYAT-LEDVMTN--CDGYTPE-------G---ISFPNELTQKKLLEAIYK-R-AGVQS-DQLAYMELHS-----------------------------------------------------------------------T-GTKV------G------DKVEVGAVT-DVLS-PG--R------------------------------------------------------------------S-----S-PLPIGSVKGN-MGHSEATAGMASLMKCLLVARYRKIPPQLN-YV-----N--PNPRIP------------------------------------------------------------------------------------------------------------------------------------------------------------- 162 ------------------------VVISGISCRLP-Q-S--D-NMEEFKDNLM-NGIDMV-TE---DDS--RW-KPGT--------------Y--G-LPRRNGKLK--------DLSK-FDASFFGVHPK-QANSMDPQLRLLLEVTYEAIIDAGINP--------DLVRGS--RTGVYI---------------------------------------G-ASASES--HDAW-SI---D------------P--E-STVGYSMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------YTIDTACSSSLLALDQALHSIRSGQCDAAIVGGANLCLKPAVAVQFMKLGMLSPD-GMCKSFDAEGNGYCRSEGIVAIYLQRES-Q--------------A--RR----IYC-NLVHSKTN--SDGNKQQ-------G---ITFPSGDIQKRLLHEVYSE-A-CIDP-SQISYIEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIT-DVFC-K--Q---R----------------------------------------------------------------N----T-PLLIGSVKSN-MGHSEPASGLAAVAKVIVAMEEGVLPGNLH-Y---K--S--PNLDIPGLTNGKLQVVD--QNV-KWDG-----------GHVGVNSFG-FGGSNVHSILKSK----NNN--N-K----H-L----LCE--GN-E-------------------------K------KRLFNYCSRTEEGLKKT--L------------------ 163 ------------------------VAIIGIGCRVP-G-A---DNIEEFWRVLE-NGENHI-VDIP-A--E-RW-NNDH--FYS----ET-GETGKS-FVKKAGLL-----K-G--HD-EFDYEFFKISKG-EAETIDPQQRLVLECTHMAFEDGGITR--------DKLDG--SDTSVYV---------------------------------------G-AMNDDY--KGLS-ND-----------D----H--D-EETNYSATGMSSTYISARISHAYNLHGPC------TMVDTACSSSMMAIHLGCQSIKTGESKMAVCGGVNSILGP-DQFIVLSKAGMLSRTGQCQTFCDTAD--------------------------------------------------------------------GYARSEGCGIVILKSYK-Q--------------A--IDDGDKIWG-LIR-TGTN--QDGRTAL-------S---VAAPSSEQQLELLKRMYKQ-Y-DVDP-TSLQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPVEIAALG-QFIS-SS--S---------KGLDQCHESS---------VNSGATNDIR-------------------EC-TQGI--G-----N-TIRIGSVKTN-IGHLESAAGVVSLIKVLLMMEHGRFVPSLH-IK-NDMSN--LNKNIK-LREHGLSIST--DTS-EWEH--N-A--N-GERSACINSFG-FGGSNVHAIVNQPR----QD--Q-S----H-----R-RE--TL-D-GI---KV-------------------------INIS-A-QNRQSLSRML-------------------- 164 --------------------------ISGIAGRFPK--S---NNLHEFWENLI-NGVDML-G-------PTRW-PPG---LYG--------------LPPRSGTIP------N--LGT-FDSDYFGYAE-NEARNSNLLLRVLLEVIYEGVVDSGFTL--------TSLRSD--RTGLYL---------------------------------------A-CTFSDG--DAI-AT---------------------SSV-LDSSHTNLRSSLLQRLVDWYKFQGPM------MTVDTACSSSLSALQMAVTDLNAGRCNYAVVTGINLIVSP-NCSQCFNQLSMLSPTGDSHVFDVSAN--------------------------------------------------------------------GYVRSDGVGVVILTRIP-D---------------ICTR----IYAS-IADIAVN--CDGHKEE-------G---IVYPSRRSQCSLLKSLYG-D-NLIPS-ACLAYVEAHG-----------------------------------------------------------------------T-GTQA------G------DKLELNALM-DALC-EG--R------------------------------------------------------------------D-----D-PLLVGSVKSN-MGHCEAASGLAGLMKCILSVHHGVIPPNLH-YK-----S--PNLGIEGIPLGKVKIVD--TLQ-PLKG----R----I-NVIGVNSFG-FGGVNGHVVLMSYK----NP--R-D------E---G-ED--A----C------------------------------TYLVPVTARSSAGVDKI--------------------- 165 ------------------------IVISGISGRLP-E-S--D-NMEEFRENLM-SGHDMV-TE---DDR--RW-QPGL--------------H--G-LPRRNGKLK--------DLSK-FDASFFGVSPK-QADAMDPQLRLLLETAYECIVDAGVNP--------LSIRGT--RTGVFI---------------------------------------G-SSFSEA--AEAW-AS---D------------T--G-KTIGYAMTGCCRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------FVVDTACSSSLLALDQALHSIRNGHCDAAIVGGCGLLLKPGTSVQFLQLGMLSPD-GKCKSFDASGNGYCRSETVGTVFLQKSS-D--------------A--KR----VYA-TVVHSGTN--ADGNKEQ-------G---ITFPSGQVQKELLQQVYTE-A-CIDP-ASVSYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIS-DVFC-K--G---R----------------------------------------------------------------Q----D-PLLIGSTKSN-MGHPEPASGLAAMAKVLIAMEDKVLPPNLH-F---E--E--PNTDIPALLDGRLTVVT--KPT-QWNG-----------GYVGINSFG-FGGANVHAILKSN--E--KE--P------T-G----FHP--DA-N-------------------------S------PRLVTYSGRTEESVQCVL-------------------- 166 ------------------------IVISGISARLP-E-S--D-NIDEFREHLI-KGEDMV-TE---DDR--RW-PPGI--------------Y--G-LPTRNGKLK--------DLTK-FDATFFGVSPK-QADNLDPQLRMLLETTYECIVDAGIDP--------AAIRGS--KTGVFI---------------------------------------G-SSMSEA--AEAW-GA---D------------P--S-NIVGYSMTGCCRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------YNVDTACSSSLIALDNAVQSIRNGYCDSAIVGGSGLLLKPATSLQFLQLGMLSPK-GKCNMCDASGDGYCRSETVGTLFLQKAA-D--------------A--KR----IYC-TVVNTGTN--ADGNKEE-------G---ITFPSGQMQKQLLEQVYSE-A-CVDP-STVAYVEAHG-----------------------------------------------------------------------T-GTAA------------GDPQEMNTIA-DVFC-K--G---R----------------------------------------------------------------Q----G-PLPVGSTKTN-MGHPEPASGVAAIAKVLIAMEDGMIPANLH-F---E--T--PNPNIPGLVDGRLEVVT--TRK-RWNG-----------GYVGLNSFG-FGGANAHAILKSH--E--KE--P------T-G----PHP--EA-K-------------------------N------CRLVTYAGRTEEGVKKVL-------------------- 167 ------------------------VAIIGLGCRTP-G-A---DNHREFWRVLE-RKENHV-GDVP-K--D-RW-NAAA--YLDP-----NHAKGKA-YVQKGGFL-----K-D--VR-GFDNLLYSISEF-EAAQMDPQQCVLLECTSMALEDAGITR--------KKLAG--SNTGVYV---------------------------------------G-AMHQDY--GSTF-VG-----------Q----V--S-KGDEYTASGITNTILASRLSYIFDLRGPC------MVLDTACSVSMVAIHQGCLALRSGDCDMAICGGVNCMLTP-HIFLLLCEARMVSPTGQCHAFSKNAD--------------------------------------------------------------------GYARSEGCGVIILKRLK-D--------------A--LRDGDKIWA-TLN-TGTN--QDGRTVS-------P---MLQPSGEQQLRLLRHVYDT-H-RIDV-SKMDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEANALG-TFLK-EK---G----Q------------------------------------------------------------K-----K-TVYMGSLKTN-IGHTEAAAGVLGVIKIVLMMKHGKIVPSLL-C---E--E--VNPKIN-LPDLKLAIPQ--SLV-PWES--T-------NKIAGCNSFG-FGGSNAHAVVQAYN----SQ--S------------H----------G-----------------------------------------------H-------------------- 168 ------------------------IAIIGIGCRTP-G-A---DNVREFWNLLQ-KGKCHI-TDVP-A--D-RW-NSKA--YLD----TNKQAFGKA-YVQKGGFI-----N-D--IF-SFDNDLYDISEF-EASSMDPQQFLLLDCTFMAMQDAGLTC--------KQLAK--SQTGVFI---------------------------------------G-AMNNDC--DCIS-LG-----------K----N--S-TLDVYTATGVRMTILASRLSHVFDLRGPC------MVIDTACSAAMVSMHQACLSIRAGDCDLAVCGGVSLMLTP-DMFFKLSKAGMISPTGLCHTFSELAD--------------------------------------------------------------------GYTRGEGCGIVILKRLQ-E--------------A--VRDGDKIWG-ILD-TGTN--QDGREVR-------Q---ITSPSMEQQRKLLHSFYNK-C-KVDV-DQIDYIEAHG-----------------------------------------------------------------------T-GTGA------G------DKAEVEALG-LFLQ-ER---S-T--Q------------------------------------------------------------A-----R-TRFIGSAKTN-IGHTESASGVLSLIKVLLMMKHNTIVASLH-S---Q--P--PSKSFD-LTKYKLEIPQ--EPV-EWSN--P-------NKIAGCNCFE-FGGSNVHAVIRSFT----PT--P-----------------------------------------------------------------------A-------------------- 169 ------------------------IVVSGISCRLP-E-S--D-NMAEFRDHLV-KGEDMV-TD---DGR--RW-QPGL--------------H--G-LPTRSGKLK--------DISK-FDSSFFGVNPK-QAHAMDPQLRLLLEVTYEALIDAGVKP--------QSVRGT--RTGVFI---------------------------------------G-ASASEA--HEAW-ST---D------------P--E-KTVGYCMTGCQRAMFANRLSFAFDFKGP------S--------------------------------------------------------------------FTMDTACSSSLLAMDQALLNIRLGLCDAAIVGGASLCLKPQTALQFMKLGMLSPD-GACKSFDESGNGYCRSEGIVAIFLQKRP-D--------------A--RR----VYS-TVLHSKNN--ADGSKEQ-------G---ILFPSGEQQKKLVKEVYRE-S-GVNP-VDVQYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNSIA-EVFC-E--N---R----------------------------------------------------------------Q----E-PLLIGSTKSN-MGHPEPASGLAALAKLVIAMEDGVIPANLH-F---Q--S--PNPDIPALADNRLKVVS--EAT-PWKG-----------GLAAINSFG-FGGTNVHAILKSN----SI---N-N----G-P----HVS---A-N-------------------------C------KRLFLGSSRTQEGLDEIL-------------------- 170 ------------------------IAIVGMGCRVP-G-A---ENLDEYWNVLL-RGEDHV-REVV-D--DSRW-DFKS--HYS----TDVNAPGKT-YAKCAGLL-----K-D--LD-KWDYQFHGTSQV-EAETIDPQQRLVLDCSHMAMEDGGFTR--------KELNG--TNTGVYI---------------------------------------G-SMGDDF--RSTF-LD----------------K-ND-VKDPYTSTGLFRTITSSRLSYELNLLGPN------MVIDTACSSSSVAIHLACQGLKTGDCNLAFAGGVNVLLDP-KAFATLSKSKMLSPSGKCHAFSSNAD--------------------------------------------------------------------GYVRGEGCGIVILQKLA-D--------------A--EREGRNIWG-VIE-TGTN--QDGRMAR-------P---LTAPSEKQQLELMKKVYKD-R-RYWK-NAIQYIEAHG------------------------------------------------------------------------TGTVT------G------DKTEVHALG-KHFK-NT--PT-A--K------------------------------------------------------------D-----Q-GIYLGSVKTN-IGHLESAAGVCGLVKVCLMMKYETIVPSLL-YS-KD--K--ANPELK-LDSYNFIVPT--VNV-KWTA--D-R--N-STRCACVNSFG-FGGSNAHIAVKQIC----QN--S-K------H---K--------------------SN-KLK--------Q------KYLVIVSSQSLKGLK--K-------------------- 171 ------------------------VVISGVSCRLP-E-S--D-NMNEFRDHLM-KGEDMV-TS---DDR--RW-KAGL--------------F--G-LPTRSGKLK--------DITK-FDAGFFGVHPK-QADSMDPQLRLLLEVTYEAIVDAGVNP--------DTIRGS--RTGVFI---------------------------------------G-ASASES--HDAW-TA---D------------P--E-STVGYTMTGCTRSMFSNRLSYFFDFKGP------S--------------------------------------------------------------------YTLDTACSSSLLAMDQALLSIRSGLCDAAIVGGSNLCLNSLTALQFQKLGMLSPE-GKCKSFDAEGDGYCRSEGVVAIFLQTKL-V--------------A--KR----AYA-TLVHSKTN--SDGNKEQ-------G---ITFPSGEVQKRLLHEVYSE-A-GVDP-SRVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIC-SVFT-K--G---R----------------------------------------------------------------Q----G-PLLIGSTKSN-MGHCEPASGLAAVAKVLLAMETGEIPANLH-Y---K--S--PNPDIPGLQDGKMKVVT--KRT-KWDG-----------GYVGVNSFG-FGGSNVHVLLKSK----SSS--E-ET---G-R----DKR--LC-K-------------------------K------KRLLNYCSRTEEGLHAVL-------------------- 172 ------------------------IAIIGIGFKGP-G-A---ENLEQLWEVLE-GGKNCV-LDLP-K--D-RW-NVDA--FYD----PDPQATGKY-YTRKAGLL-----S-N--PL-DFDNTFFDINDI-ESDQMDPQQKFVLECSYRAMEHAGITR--------RSVKG--SKTGVYI---------------------------------------G-AMNCDY--RGLF-PV-----------G----Y--S-VVSNYTVTGVSNSIIAARVSYTFDLRGPC------LVLDTGCSSALIAIHTASQAVLNGDCTMAICGGTNFIGSP-DIFIHLSKAQMVSPTGQCHAFSEQAD--------------------------------------------------------------------GYTRGEGCGIVLLKKLS-D--------------A--ERDNDKIFA-IIT-TGTN--QDGHTVT-------P---ISAPSMSQQIQLLDDMYRD-F-SLEQLDEIEYIEAHG-----------------------------------------------------------------------T-GTQA------G------DYAEANALG-KFFK-KR---G----S------------------------------------------------------------F-----K-KRLIGSIKTN-IGHLESAAGVVGLIKVLLMMEHSKIVSSLF-SE-----S--PNKRID-FEALNLVVAS--RVT-DWTT--E-------NKVACVNSFG-FGGSNCHAIVRSVV----QR--H-C------K---T-AA---------PT----------NQE-----N-K------TSVVCFSGKTVTS----L-------------------- 173 ------------------------IAVIGAGFKGP-G-A---DNLEQLWMVLE-NGENKI-SEIP-K--D-RW-NSDA--FYD----SDTEATGKY-YSRKAGLL-----S-N--PH-EFDFSFFNISEI-ESEQMDPQQKFVLECTYRAMEHAGITR--------DKIKG--TKTGVYI---------------------------------------G-AMNCDY--RGMF-PA-----------R----S--A-GVSNYTVTGISNSIIASRVSFTFDLRGPC------LVLDTGCSSALIAIHTASQALTLGDCSMAICGGTNFMATP-DVFVHLSKAQMLSRSGQCHAFSDQAD--------------------------------------------------------------------GYTRGEGCGIVILKKLS-D--------------A--ERDNDPILA-VIS-TGTN--QDGHTVT-------P---ISAPSMSQQIQLLEDVYRD-F-SLEQLDEIEYIEAHG-----------------------------------------------------------------------T-GTQA------G------DYAEANALG-QFYK-NK---G----S------------------------------------------------------------S-----K-KRLIGSIKTN-IGHLESAAGAAGLIKVLLMMVHDSIVPSLF-SE-----R--PNKRIN-FDDLNLVVPS--KVR-EWST--E-------KKVACVNSFG-FGGSNCHAIIRSYN----AP--H-S------G---Q-NT---------R---------------------------------------------R-------------------- 174 ------------------------IVIVGIGCKFP-G-A---ENKDEFWNVLL-NGENHV-IEIP-P--E-RW-KVDH--HYD----PDPDTPGKT-YVRRAGLI-----K-S--YD-VWDNRFFGISDV-ESERMDPQHKYVLECVHMAMEDGGLTR--------KKLAA--SDTGVYI---------------------------------------G-AMNDDY--KGAW-ND-----------D----L--K-ATDNYSLTGSSSSIISARVSFVYNLHGPS------MVIDTACSSSLVAMHVATQAIKSGDCSMAICGGVNCILYP-DMFIPLSKARMVSPTGQCHAFTANAD--------------------------------------------------------------------GYARGEGCGIVILKKKK-Q--------------A--IADGNKIWA-EIS-TGCN--QDGREAT-------P---ITAPSGDQQEKLLEKVYSG-K-NLNA-ADIQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEVNALG-NYFG-KR--K-G----------------------------------------------------------------E-----K-NIFIGSVKTN-IGHQESAAGVAGLIKTLLMMKHGKIVSSLF--FSEN--N--ANRKID-FESFGFVVPT--EII-EWKP--T-S--D-NNRVACVNSFG-FGGTNSHAVLKQ------------------------------------------------------------------------------------------------------- 175 ------------------------IAIIGIGCRFP-G-A---DNIDEFWKVLL-HGENHV-VDIP-K--E-RW-DVDA--IYD----ADPDAPGKT-YVRKAGLI-----P-R--HD-TWDNNFFGISDI-EAEQIDPQQRLVLDCVQMTMENAGIRK--------TDISG--SLTGVYI---------------------------------------G-TMNDDY--MFAL-ND-----------D----L--D-EVNNYSVTGSARSIISARVSYTYNLLGPS------MTIDTACSSALVAIHTGIQAIKLGDCNMALCGGVNSILYP-ELFITLSKARMLSPTGQCQAFSAKAD--------------------------------------------------------------------GYARGEGCGIILLKKLS-E--------------A--QKDGDYIWG-TIT-TGCN--QDGHESS-------P---ITAPSLVQQKRLLEKVYKE-N-GVDP-CSVQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEVDSLG-TFFS-EH--RA-Q--QT--------------------------------------------------------E--I-----K-NIMIGSVKSN-IGHTESAAGVAGIIKILLMMKNSLIVPSLH-SE-E------LNPKIP-FDQYKFCVAQ--NNT-VWEK--D-P--S-ERRIACVNCFG-FGGTNSHAIIEQVK----NPYDT-K---LH-T---S-L--------EN---LENI-E-----------S-R------PYLIAISAADSWSLEQL--------------------V 176 ----------------------------------------------------------------------------------------------------------------------------------------------------------GFTR--------EMIKG--TDTGVYI---------------------------------------G-CMNKDM--SLGL-N------------E----A-AH-EYNNSLVTGMASSIISNRLSYFFDIRGPS------LTIDTACSSALVAIHLGCQAIRSGDCSMAICGGVNSMITP-INYIPLIKAGMTSKTGKSHTFSKDAD--------------------------------------------------------------------GYARGEGCGMVVLKSLK-QAKK----------------DGDKIWA-VIM-SGCN--QDGKENT-------P---ITAPSGKQQIELMERLYSL-H-GISP-ADIQYIESHG-----------------------------------------------------------------------T-GTPI------G------DPTETNALA-EFFS-PF--LS-K---------------------------------------------------------------D-----R-KIPIGSVKTN-IGHLESSAGTAGLIKILLMMKHAKIVPSLH-YS-KE--N--ANPNID-FDSIPLEVST--DIR-IWKE--R-N--D-GTRISCINSFG-FGGTNSHAVIKQL------------------------------------------------------------------------------------------------------ 177 ------------------------IAIIGIGCMFP-G-A---ENLDEFWKVLE-NGEDHV-QDIP-P--E-RF-NVQA--FYD----PDPDHPYKT-YVKKAGLL-----Q-R--FD-EWDNRFFGISDK-EAELVDPQQHFVLESVHMALEDAGIPK--------ETIAG--SNTGVYI---------------------------------------G-AMNHDW--DGVL-RS-----------A----R--H-KSTNTTVTGTDSSILSARVAYFYNLLGPA------ITINTACSSAMVAFHTASQALRTGEISMAIAGGVSFILDP-NVFINLSSARMASPTGKCHTFSKDAD--------------------------------------------------------------------GYARGEGCGIVLMKRLA-D--------------A--VRDDNKIWG-TLF-TGLN--QDGHMSS-------P---ITSPSGDQQEKLLHTVFEK-C-RIPP-HHVQYIEAHG-----------------------------------------------------------------------T-GTSV------G------DFTEVSALG-KFFS-KH--A------------------------------------------------------------------L-----H-NIPIGSVKSN-IGHLEPGAGAAALIKVLLMMKNQKMVPSIH-AE-P------QNHRIP-FNELKLYVCQ--KQS-GWFP--N-D--N-NRRIASINCFG-FGGTNTHAIVTDYQ----K---T--------------KI-----P---------------------------------------------------------------------P 178 ------------------------IAIIGIGCRFP-G-A---SCLREFWQVLV-NGENHV-VEIT-D--D-RW-NNDA--YYD----KDPRTPGKS-YAPRAGFI-----K-N--YA-HFDFKMFGMNEH-EAAQMDPQQRQVLECTYMALEDAGITR--------QQIAG--QKVGVFL---------------------------------------G-CMNNDF--TQLA-NK-----------H----P--H-LVDNFTVTGTGNSIVSNRVSYAFDLRGPS------MTIDTACSSSLVAIHQAGLAMKEGDCSMAICGGVNLLLSG-GVFVPLSKAQMLSPTGQCHAFSANAD--------------------------------------------------------------------GYTRGEGCGIVIIKPFK-Q--------------A--LEDGDNIWG-TLV-TGLN--QDGHVAK-------P---LTAPSGEQQAQLIQDVYTK-H-GIDP-ASIDYIEAHG-----------------------------------------------------------------------T-GTKI------G------DPTEVSAFG-HFFL-QQ--QQ-S--R------------------------------------------------------------R--------RYIGSVKTN-IGHLEAAAGVAGLIKVLLMMKHSTIVPSLH-FD-KP------NEEID-FDRFQFDVPT--KTV-PWLP--D-------QKVACLNSFG-FGGANSHALVKCIS----NR--Q-I------N---S-T----Y-S-----------------C-----T-K------PTVICFSGSNHQT----L-------------------- 179 ------------------------IVISGISARLP-E-S--D-NMDEFREHLI-LGEDMV-TE---DDR--RW-PPGF--------------L--G-LPTRNGKIK--------DLSK-FDATFFGVSPK-QADSMDPQLRLLLETTYECIIDAGVDP--------HTIRGS--KTGVFI---------------------------------------G-SSFSEA--AEAW-GS---D------------T--S-STIGYAMTGCCRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------YVLDTACSSSLLALDQAVHSIRNGHCDAAIVGGSGLLLKPGTSMQFMQLGMLSSE-GKCKSFDASGHGYCRSETVGTLFLQKSS-V--------------A--KR----IYC-TVVHTGTN--ADGNKEQ-------G---ITFPSGEIQKQLLQEVYTQ-A-GVDP-SSVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIA-DVFC-K--G---R----------------------------------------------------------------Q----G-PLLIGSTKSN-MGHPEPASGLAAVAKVLIAMEDGMIPANLH-Y---E--T--PNPDIPGLIDGRLEVVT--QRK-RWNG-----------GYVGINSFG-FGGANVHAILKSH--E--KE--L------T-I----PHA--EA-N-------------------------T------VRLVTYSGRTEESVARVL-------------------- 180 ------------------------IAIVAIGCRVP-G-A---ENLDEYWKVLL-GGENHV-REVS-D--D-RW-DFSS--HFS----TDVNAPGKT-YANFAGLL-----E-N--LD-EWDYQFHGTSQA-EAETIDPQQRLVLDCSHMAMEDGGFTR--------KELNG--TNTGVYI---------------------------------------G-SMGDDF--KATF-LD----------------Q-ND-VRDPYTSTGLFRTITSSRLSYELNLLGPN------MVIDTACSSSSVAIHLACQGLKTGDCDLAFAGGVNVLLDP-KAFATLSKSKMLSPTGQCHAFSSDAD--------------------------------------------------------------------GYVRGEGCGIVILQRLD-D--------------A--EREGRNVWG-VIK-TGTN--QDGRMAK-------P---LTAPSEKQQLELMKKVYKD-C-EDWK-NAIQVIEAHG------------------------------------------------------------------------TGTVT------G------DKAEVQALG-QHFK-CT--ST-A--E------------------------------------------------------------D-----R-GIYIGSTKTN-IGHLESAAGVCGLIKVCLMMKNETIVPSLF-YS-EE--K--ANQELK-LDSYNFIVPT--DHL-KWTA--D-R--N-STRCACINSFG-FGGSNAHIAVQQVC----QK--P-K------N---K--------------------SS-KLK--------Q------KYLVMVSSQSLNGL------------------------ 181 ------------------------IAIVGVGCRFP-G-A---NNLEEFWKVLL-RGENHV-HEVE-N--N-RW-DFQS--FYD----PDKSAPGKS-YVNKAGLL-----D-N--ID-EWDNQLYGISDK-EAFCVDPQQRLVLDCCHMAMEDAGITR--------KHLDG--SNTSVYI---------------------------------------G-GMNDDF--KSCN-PD----------------Y-HG-PDAAYLVTGIFRSILSARVSYVFNLRGPC------MVIDTACSSSLVAIHLAYQSLMLRESDMAIAGGVSVLLDP-QPFVVLAKAHMLSPTGQCHAFTSDAD--------------------------------------------------------------------GYARGEGCGIVILQRLE-D--------------A--LKDGNNIWG-VIR-TGTN--QDGHAIS-------P---ITAPSSISQLDLLRRVYKD-R-KEDK-NAVQVIECHG------------------------------------------------------------------------TGTPI------G------DPTEIISLG-SFFK-DS--ET-A--K------------------------------------------------------------R-----A-KIIVGSVKTN-IGHLESAAGVAGLIKVLLMMKNETIVPSLM-YS-EQ--K--RNPKLD-FRAYNMEVAT--KKM-KWSV--G-E--N-QTRVACVNSFG-FGGSNSHLYIRQWI----PK--K-S------A---S-RT-----K--I--D-----VD-RSL--------S------RKLVTISNLQDKGLKQSL-------------------- 182 ------------------------VVIGGISCRLP-Q-S--D-NMQEFRDNLM-NGIDMV-TE---DDH--RW-PPGL--------------Y--G-LPKRGGKLK--------DLSK-FDASFFGVHPK-QANCMDPQLRLLLEVTYEAIIDAGYDP--------QEIRGT--RTGVFI---------------------------------------G-ASASEC--HEAW-TG---E------------P--E-RTQGYTMTGCTRSMFSNRLSYFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLLALDQALHSIRNGQCDAAIVGGSNLCLKPTTALQFLKLGMLSPE-GMCKSFDANGNGYCRSEGVIALYMQKQS-S--------------A--KR----IYC-SIVHSKTN--SDGNKQQ-------G---ITFPSGECQKKLLQELYSE-A-CIDP-TKVLYLEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIT-DVFC-K--G---R----------------------------------------------------------------L----E-PLKIGSVKSN-MGHSEPASGLAAVAKVIIAMEEKTIPGNLH-Y---S--S--PNPDIPGLQDGRLQVVT--GKT-TWLP-----------GYVGVNSFG-FGGSNVHTLFHSN----SSS--D-M------R----VIQ--DC-T-------------------------G------KRLFLYASRTAAGLTEVL-------------------- 183 ------------------------IAIVGAGCRFP-G-A---ENLEEFWRVLV-NGEDRV-KDIP-D--S-RW-NTSA--FYD----EDKSAPGKI-YVKKAGLL-----D-N--HD-KWDNKLFGISDV-EASRIDPQQRYVLECVHMALEDGGFTR--------KQISG--SKTGVII---------------------------------------G-CMNDDY--KSIA-NS-----------D----L--N-DIGSYNATGTSVSVISARVSYVYNLHGTC------LTLDTACSSSLIALHLASQAIQTGDCDMVICGGVNSILTP-DTFKAPCEARMMSAIGQCQSFCDTAD--------------------------------------------------------------------GYARGEGCGIVILKRLK-E--------------A--VEDGNKIWA-TVK-VGSN--QDGCTTK-------P---MTAPSGDQQLELFRRVYKT-Y-QFDP-SDIQYIEAHG-----------------------------------------------------------------------T-GTPR------G------DPTELNALG-EFFS-SF--RK----ET--------------------------------------------------------S--------E-PLLVGSVKSN-IGHSESAAGVAGLLKVILMMKNGLYVPSLH-VS-SDKSN--LNPKIR-LTEFGLEISS--HVK-EWHY--N-V--A-MERHACLNSFG-FGGSNTHVIISQ------------------------------------------------------------------------------------------------------- 184 ------------------------IAVVGIGCRVP-G-A---ENLDEFWRVLT-EGENHV-NEVS-D--D-RW-DFSN--YFS----TDGNAPGKT-YAKFAGLL-----K-D--LD-KWDYQFHGISRA-EAETMDPQQRLVLDCSHMAMEDGGFTR--------SGLNG--TNTGVYI---------------------------------------G-SMGDDF--KSTF-LT----------------Q-ND-VKDPYTSTGLFRTITSSRLSYQLNLLGPN------MVIDTACSSSSVAIHLACQGLKTGDCDLAFAGGVNVLLDP-QAFATLSKSKMLSPTGQCHAFSSDAD--------------------------------------------------------------------GYVRGEGCGIVILQRLS-D--------------A--EREGRNIWG-VIK-TGTN--QDGRMAK-------P---LTAPSQIQQVELMKKVYKD-C-EDWK-NSIQVIEAHG------------------------------------------------------------------------TGTVA------G------DRTEVQALG-QYFQ-DT--PT-A--K------------------------------------------------------------A-----H-GIYIGSTKTN-IGHLESAAGVCGLIKVCLMMKNGTIVPSLF-YS-KE--K--ANQMLK-LDSYNFIVPT--DKV-NWKV--D-R--N-STRYACVNSFG-FGGSNAHIAVQQFF----QK--P-N------N---R--------------------SN-KLK--------Q------KVLVIISSQSRKGLE--K-------------------- 185 ------------------------IAIVGAGCRFP-G-A---DNLEEYWRVLV-NAENHV-KEIT-I--E-RW-NHQA--YYD----ADKNAKGKY-YVTRAGLL-----N-S--HD-KWDNKLFGIGDN-EATQIDPQQRYVLECVHMALEDAGITR--------AQLNG--SKTGVMI---------------------------------------G-CMNDDY--KALL-GS-----------D----A--D-EYTSYSATGMSTSVISARVAYVYNLHGTC------LTLDTACSSALVAIHLASQALKTGDCDAVICGGVSSIIDP-STFIPLCRAKMMSSEGQCQTFCETAD--------------------------------------------------------------------GYARGEGCGIVILKRLS-D--------------A--LRDGNKIWG-TIQ-TGSN--QDGCMAK-------P---ITAPSGDQQAKLLEQVYKI-H-KVDP-ASIQYIEAHG-----------------------------------------------------------------------T-GTPR------G------DPTEINALG-EFFV-AH--KQ-R--NK--------------------------------------------------------S--I-----R-PLLIGSVKSN-IGHTESAAGIAGLLKVLLMMKHGKYVPTLH-VK-PDKSN--LNRKIR-LQNLNLDIAL--QVE-DWKE----I--D-GERTACLNSFG-FGGSNAHAVVKQ------------------------------------------------------------------------------------------------------- 186 -------------------------VISGVACRLPK--S---ENAEEFWQNLM-NGVDMV-G-------PTRW-PPT---LHK--------------LPPRSGHIT------T--LNK-FDAKFFGYSD-SEADDMNLLMRQLLEVIYECIVDSGLPM--------KTLQGS--RTGFYL---------------------------------------A-CTFSDA--DCI-TT---------------------STA-KHPQMSNLKQSLVSHMTETFGLSGPV------FSVDTACSSSLAALQVAFSDLQCGRCQYAIVAGSNLIVSP-STSLQFHQLSMLSPTGQSQAFDTKAN--------------------------------------------------------------------GYVRSDGVVAFLLARES-S---------------LCRR----VYAN-VIDCGVN--CDGYKPE-------G---IVFPSQSSQANLLNSLYG-GTRGVDK-SRVAYVEAHG-----------------------------------------------------------------------T-GTQA------G------DKAELTALS-SVFS-VG--G------------------------------------------------------------------R-----K-SLLVGSVKSN-MGHCEAAAGLAGILKCILSVNHGQIPPNLN-YH-----V--PNPNIDALMEGKIKVVD--RAT-QLID----G-------FIGVNCFG-FGGVNGHVILKPYK----ST--R-K---------------------------------------------------------------------P-------------------- 187 ------------------------VVISGISGRFP-E-S--D-NMEEFRQHLV-RGEDMI-TD---DDR--RW-QSGL--------------F--G-LPKRSGKLK--------DLSK-FDASLFGVHPK-QANAMDPQLRILLEVSYEALIDAGVNV--------SGVRGS--RTGVFV---------------------------------------G-CSQSES--SEAW-TS---N------------P--E-TQVGYSMTGCCRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSMLAMDQALTSIRTGQCDAALVGGCSLCLKPGMALEFNKLGMLSSD-GKCKSFDATGDGYCRSETVAVVYLQKAP-A--------------A--KR----IYA-TVVHSKNN--SDGHKEQ-------G---ITFPSASIQKRLLHELYSE-A-GVNP-SDVSYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNTIV-DVFC-H--K---R----------------------------------------------------------------T----E-PLLIGSIKSN-MGHSEPASGLASIAKVLIAMEAGVVPPNLH-Y---T--T--PNPDIPALTDGRLQVVT--ECT-RWKG-----------GYVAVNSFG-FGGANVHVLFKSY----PKE--R-Q------S----AHP--AS-P-------------------------L------TRLVTHCSRTEEGLAQMF-------------------- 188 ------------------------IAIVGIGCRFP-G-A---DNIDEFWRVLL-NGENHV-KDIP-P--D-RW-DNDK--FYS----DDPDEPGKT-YVRKAGLL-----S-D--HM-KWDNRLFGISDN-EAVRVDPQQRYVLECTHMALEDGGFTR--------EQMAG--SKTGVFI---------------------------------------G-VMNDDY--KGLT-GT-----------D----H--G-EDTTFTATGLSTTVIASRLSYVYNLQGPC------MTVDTACSSGMMALHLGCQAIRSGDCEMAICGGVSSILSP-DMFIPLCKARMLSRIGQCQTFCDTAD--------------------------------------------------------------------GYARAEGCGVVILKSFK-K--------------A--SIDKCNIWG-IIK-TGIN--QDGRTAT-------P---MTAPSSKQQQQLLFDVYTK-H-NVNP-RDLQYIEVHG-----------------------------------------------------------------------T-GTPV------G------DPTEVNAFA-SFFN-SF--DE-V--SSNSVHVK--------------------------------------------------S--G-----Q-KILIGSVKTN-IGHTESAAAMAGLIKVLLMMKHGKVVRSLF-IN-TDMSN--LNSKIS-IDNTALQIAV--TQE-DWPP--N-L--D-GGRLACVNSFG-FGGSNGHAIVQQIP---------------D-----V-IS--N----------------------------------------------------K-------------------- 189 ------------------------VAIVGVGCKFP-G-A---DNVAEYWRVLK-NGENHV-KQVP-R--D-RW-NNEA--FYD----PDQNAPGKT-YLRTAGFV-----N-S--IN-EWDHRFYGISDM-EAELVDPQQRIVLDCVHMALEDGGITR--------NDIKG--TQTGVYI---------------------------------------G-SMNGDY--KGQV-IG-----------D----T--I-SSSAYAVTGTHNSIISARVSYTYNLFGPA------MTIDTACSSSLVAIDVASQAIRTGKCSMAICGGVNILMDP-HLFVVLAKAGMLSPTGQCKTFTKDAD--------------------------------------------------------------------GYARGEGCGILLLKLLN-D--------------A--VKDGNKIWG-TIK-TGTN--QDGRMAE-------P---ITAPSGLQQERLIKELYER-Y-NVDR-AKIKVIEAHG-----------------------------------------------------------------------T-GTAI------G------DPTEANVLG-SCFG-RK--A-KM---------------------------------------------------------------L-----S-NVFIGSVKTN-IGHLEAAAGVAGIIKALLMLKHAVIVPSLW-YT-PE--N--ENPKVK-LTENGFIVPT--QCT-PWTR--T-G--V-ETRLACVNSFG-FGGTNAHAIVEEHK----ET--A------Q-I---Q---------------------T-SHAS--S--P-L------PNIIAVSAIDQTS------------------------L 190 ------------------------IAIIGIGCRVP-G-A---DNIDEFWRVLV-NSENHI-IDVP-E--E-RW-NNDA--FYS----ENRDEAGKT-YVKKAGFI-----K-G--HD-EWDNKFFGVSDT-EAINVDPQQRLVLECTQMALEDAGLTK--------GHIQK--TQTGVYI---------------------------------------G-AMNEDY--KGLN-VF-----------E----H--K-DDTNYSATGMSSTIISARVSYFYDLRGPC------MVVDTACSSSMIAIHLGSQAIRTGDCEMAICGGVNCMLSP-GQFMTLCKAKMLSPTGQCQSFCDTAD--------------------------------------------------------------------GYGRGEGCGIVIVKSYE-K--------------A--VRDGNKIWG-IIK-TASN--QDGRAAQ-------P---ITAPSGEQQKELLKKMYRH-Y-GIDA-TTLQYIEAHG-----------------------------------------------------------------------T-GTAV------G------DPTEVNALG-AFIA-QY--R---------SDK-TDEKRSVYSG----DESVYTDSTIDTKTVID--------K---S-----QT--K-----S-SILIGSVKSN-IGHLESAAGVAGLIKVLLMMKNGKYVPSLH-VK-KDKSN--INRKIA-LDLYGLDVSV--AVT-EWLP--N-D--D-GDRICCVNCFG-FGGSNTHAIVIQKR----S---------------------------------------------------------------------------F-------------------- 191 --------------------------ISGISCRLP-Q-A--D-NVEEFHQNMM-KGRDMV-TH---IRS--SL-NDSD------------Y-D--M-TQPYSGTIR--------DLTK-FDVGFFGVPPK-LADVMDPQLRILMEATCETFVDAGVSI--------EAMRGS--NTGVFI---------------------------------------G-CGLSEA--LEAY-VS---D------------P--D-HVNAYAPIGCSSAMLANRISFAFDLKGP------S--------------------------------------------------------------------YALRNGDVSGFLALERAVLSVQRGQCEAAVVGGSNLCLKAAASFQLMMLDLLSPD-GKCCCCNEDSCGTNRSEGVVVMLIQKRK-F--------------A--KR----IYS-TIRHIKCT--SMK-----------N---SFYPSYEEETKLLNEVYKE-A-DVDP-TKVSYVEISG-----------------------------------------------------------------------S-CNVD------------ADAQEVNSVA-DVCC-K--D---R----------------------------------------------------------------E----K-PLRIGSVKTN-VGNTETASGLVSILKVLMAAQEGMIPSNLH-V---G--T--PNQCIEALHDGRIEFLS--ERK-RWTP-----------GIVGVSCNG-MGHMHGHCILDFT--S-NPP-----------D----ANK--SQ-E--------------------------------KRLAVFSATSELGVKSVL-------------------- 192 ------------------------IAIVGIGCMFP-G-A---ENIDEYWNVLL-NGEDHV-QDIP-T--E-RF-NVEA--FYD----PNPDHPRKS-YVRKAGLI-----K-R--YN-EWDNRFFGISDK-EAGMVDPQQHFVLESVHMALEDAGIPK--------EKIAG--SDTGVYI---------------------------------------G-AMNHDW--NCLL-RS-----------A----R--Q-KTTNTTVTGGDSSILSARVAYFYNLLGPA------MTIETACSSSMVAVHTALQALKNDEISMAIVGGVSFILDP-EVFIHLSSARMASPTGKCHTFSQNAD--------------------------------------------------------------------GYARGEGCGIVIMKRLS-D--------------A--LRDKNKIWG-ILY-TGLN--QDGHMSS-------P---ITSPSGEQQQKLMETIYTR-Y-NIPP-ESVQYIEAHG-----------------------------------------------------------------------T-GTSV------G------DFTEVTALG-SFFS-KH--S------------------------------------------------------------------S-----K-EIFIGSVKAN-IGHLESGAGVAALIKVLLMMKNGLYVPSIH-AE-P------LNPKIS-FNEYHLKVCQ--EVT-EWKK--N-E--K-GNRIACINCFG-FGGTNAHAVVTDH------------------------------------------------------------------------------------------------------ 193 ------------------------LVISGVSCRLP-E-S--E-NMEEFEQHLM-NGEDMV-TE---DDR--RW-QPGL--------------F--G-LPKRSGKLK--------TLNK-FDATFFGVHPK-QANNMDPQLRMLLEVTYEAIVDSGTSP--------FSIRGS--KTGVFI---------------------------------------G-ASASEA--HEAW-AM---D------------P--K-KTVGYSMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------FALDTACSSSLLALDQAVNSIRQGHCDAAIVGGCSLCLKPLTALQFLKLGMLSPD-GSCKSFDASGNGYCRSEGIVVVYLQMKP-E--------------A--KR----IYS-TVVHTKTN--SDGNKEQ-------G---ITFPSGQIQKRLLYDVYEE-A-GVAP-NKVVYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIV-DVFC-K--D---R----------------------------------------------------------------N----G-PLPIGSVKSN-MGHSEPASGLAAVAKVVVGMERGTMPANLH-Y---K--E--PNPDIPGLTDGRLQVVT--QNM-PLRE-----------GFVGVNSFG-FGGSNVHAILKSS--D--VK--R-E------N----NHK--AS-N-------------------------A------KRLFVYSSRTSDGVEKIL-------------------- 194 ------------------------VAVIGIGCRFP-G-A---TCLEEFWDVLS-KGENHI-TEVT-P--D-RW-VVED--FYD----SDPDAVGSS-YTKKAGFI-----K-D--FA-QFDHKLFGINET-EASQMDLQQAHVLECTYMALENAGITR--------NQISG--QNVGVYI---------------------------------------G-QMNNDY--SMRM-VS-----------H----P--E-LLDQYSVAGIASSVIANRVSYLFNLTGPS------MAIDTACSSSLVAIHQAILGLRAGDCSLAICGGVSLILHP-HVFTQLCKAQMLSETGQCHTFSNDAD--------------------------------------------------------------------GYTRGEGCGIVILKLAE-K--------------A--LSDGNNIWG-TIV-TGLN--QDGHFAQ-------P---ITAPSEKQQEELLNHVFTM-Y-QIDP-ETVQYIEAHG-----------------------------------------------------------------------T-GTKR------G------DPVEVRAFS-SFFS--K--SR-K--R------------------------------------------------------------Q--------RYIGSVKTN-IGHLEPAAGVAGLIKVLLMMKHNTIVPSLH-FE-TP------NEVID-FDSCHFVVPT--KCY-PWAD--E-------L--------------------------------------------------------------------------------------------------------I-------------------- 195 ------------------------VVITGISCRLP-E-S--D-NMEEFRQHLL-LGEDMV-TE---DDR--RW-PPGY--------------L--G-LPTRNGKIK--------DLSK-FDASFFGVHPK-QANAMDPQLRMLLEVTYEAIVDSGYNP--------QSVRGS--KTGVFI---------------------------------------G-VSASEA--GEAW-AA---D------------P--E-TLVGYSMTGCCRAMFANRLSYFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLLAMDQALASIRSGTCDSAIVGGSNICVKPTTALQFLKLGMLSPD-GSCKSFDASGNGYCRSEGIVAIHIQKAS-S--------------A--RR----IYS-TLVHSKNN--ADGCKEQ-------G---ITFPSGAVQKQLLEETYHE-A-HISP-SQVMYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNSIV-DVFC-R--D---R----------------------------------------------------------------K----Q-PLLIGSTKSN-MGHPEPASGLAAVAKVIIAMEDKILPANLH-Y---K--E--PNPDIPGLFDGRIKVVS--EAT-RWSG-----------GYVGVNSFG-FGGANVHAILKSN----DAE--K-R------E----HHP--AS-S-------------------------H------RRLCLYAGRTEECVAHVL-------------------- 196 ------------------------VAVIGIGCRLP-G-A---DNIEEFWRVLV-KGENHV-TDIP-Q--D-RW-NNDA--FFS----ENKNEKGKH-SVRKAALL-----Q-R--HD-EWDNKFFGISDY-EAAQIDPQQRYVLECTHMAFEDGGITN--------QELKG--SNTGVYI---------------------------------------G-CMSADY--RGLF-DL-----------D----H--D-DDNSYTITGTNDSIISARVSYVYDLSGPS------MVVNTACSSSMTAIHLGCLAIKSGDCEMAVCGGVGSILNP-NVFIPASKAGMMSTVGQCQAFCETAD--------------------------------------------------------------------GYVRGEGCGIIVLKSYA-K--------------A--IRDKNRIWG-IIR-TGVN--QDGHASQ-------P---ITAPSGKRQEELLHKLYEK-Y-SMDP-QTLQYIECHG-----------------------------------------------------------------------T-GTPV------G------DPVEVNALG-LFIQ-SH--R---------GGVSSTSHH----------NSHLERKQQANYIAKTISGCTEVS--------------------P-KILIGSVKTN-IGHLEAGAGVAGLIKILLMMRHGMFVPSLH-AK-KDRSN--WNRNIT-FDKFGLDISV--EVS-PWGQ--N-I--Q-GERIGCVNSFG-FGGSNAHCIVVQ----------------------------------------------------------------------------------K-------------------- 197 ------------------------IAVVGVGCRFP-G-A---DNAEEFWRVLV-NSENHV-KDIP-K--D-RW-NNEA--FFN----EDKDAVGKS-YVSKAGLL-----K-D--HD-MWDNKLFGVSDV-EAARIDPQQRYVLECVHMAMEDGGFTR--------AKMSG--TKTGVYI---------------------------------------G-CMNDDY--KIMS-SQ-----------D----P--S-GTTNYSATGTSTTVISARVSYVFNLHGPC------LTVDTACSSAMMAIHLGCQAIRSGDCCQAICGGVSSIMYP-DMFISLSKARMMSTVGRCQTFCDTAD--------------------------------------------------------------------GYARGEGCGVVILKPLK-Q--------------A--LRDSDKVWG-VIV-TGTN--QDGRASQ-------P---MTAPSGNQQQALLKHVYTK-Y-DIDP-STVQYIEAHG-----------------------------------------------------------------------T-GTHI------G------DPTETNALG-SFFS-KF--RG----QK--------------------------------------------------------P--------N-PLLIGSVKTN-IGHTESAAGVAGLIKVLLMMKEGKFVPSLH-IQ-RDKKN--VNKEID-LGKHNIDIPV--EVS-EWKV--N-V--K-GQRIACINSFG-FGGSNCHAVVKSA------------------------------------------------------------------------------------------------------ 198 ------------------------IVIVGVGCKFP-G-A---DNLEEFWRVLI-EGENHV-IEIP-P--D-RW-NNDA--FYH----KDPNEPGKS-YVTRAGFI-----K-K--YD-EWDNKMFNVNEM-EAAWVDPQQRYILDCVHMAMEDGGITK--------KDLNG--SNTGVYI---------------------------------------G-VMNDDY--KGSS-NN-----------D----L--N-TMTNYSLTGTSPSIISARVSYTYNLLGPA------MSIDTACSSALVAIHTASQALKSGDCEVAICGGVNSILYP-DIFVPLSKARMVSPTGQCQAFSDKAD--------------------------------------------------------------------GYARGEGAGVVILKTKK-Q--------------A--LREGNKIWA-AIA-TGCN--QDGRTTT-------P---ITAPSSIQQRNLLLKVYSE-T-GINP-EDVQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIETNTLG-KFFA-EK--LP-T--DD--------------------------------------------------------H--R-----G-SILLGSVKTN-IGHLESAAGAAGLIKVLLMMKHGKIVPSLH-FE-N------ANPNID-FNSYRLEVAR--HTS-PWPW--L-T-QG-GGRLSCVNSFG-FGGTNSHAIIKQY------------------------------------------------------------------------------------------------------ 199 ------------------------VVISGISCRLP-E-S--N-NMEEFKLNLM-DGVDMV-TE---DGR--RW-QPGL--------------Y--G-LPKRNGKLV--------DLSK-FDAAFFGVSPK-QADMMDPQLRMLLEVAYEAISDSGVDP--------SSVRGT--RTGVFI---------------------------------------G-ASVSEF--HDSL-IL---D------------P--E-TTQGYSMTGCTRSMFANRISFFFDFKGP------S--------------------------------------------------------------------YTLDSACSSSLLALNQALLAIRDGQCDSAIVGGSSIILNPLTSLEFQKLGMLSPE-GSCKSFDAEGNGYCRSEGIVVIYLQKEN-S--------------A--LR----MYS-RLIHSKTN--CDGGKDQ-------G---ITFPSGAIQKSLIQDVYSE-A-CVCP-STVAYVETHG-----------------------------------------------------------------------T-GTKA------------GDPQELNSIT-DVFC-K--G---R----------------------------------------------------------------N----T-PLPIGSVKSN-MGHAEPASGLASVAKVIVSMEEGVLPANLH-Y---N--S--PNTDIPGLVDGRLQVVT--NNK-KWDG-----------GFVGVNSFG-FGGTNVHALLESN--T--KS--D-K------N----NYC--RN-E-------------------------C------TRVFLYSARTEDGVRSVM-------------------- 200 ------------------------IAIVGLGCRFP-G-A---ENSDEFWRVLS-KGENHV-IDVP-P--D-RW-NADA--WY------HPDEPGKT-YSRKVGIV-----H-R--HD-EFDSRLYGISES-EALKMDPQQRFVLDSVHMALEDGGFTR--------AQLKG--SKTGVYI---------------------------------------G-AMNSDY--FNVS-GD-----------D----Y--K-QTDNYTLTGASKSMLASRVAYVYDLRGPA------TAVDSACSSALMAIHVACQALRSGECRLAVAGGVNGIMMH-NTMIALSRAGMTSRSGQCRAFSEDAD--------------------------------------------------------------------GYARGEGCGIVILKKLS-D--------------A--EKSNDKIYA-TLV-TGTN--QDGHMAQ-------P---ITAPSGDQQRQLLEDMYSL-H-HIDK-CTVQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEANCLG-RFFG--------Q--D------------------------------------------------------------------GKTRHIGSVKTN-IGHLESAA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 201 ------------------------IAIVGLGCRFP-G-A---ENLDEFWRVLS-KGENHV-KDVP-P--N-RW-NIDA--WY------HPNAAGKM-YTRKLGAV-----K-G--HD-EFDSRLYGISES-EALKMDPQQRFVLDSVHMALEDGGFTR--------EQLRG--SKTGVYI---------------------------------------G-SMNTDY--SNIL-SK-----------H----V--E-VADNYNLTGSASSIVAARVSYVYDLHGPA------VALDTACSSALMAIHLAAQGLTTGDCDFALAGGVNLVMIH-ISGVYLSQAGMASRVGQCQAFSANAD--------------------------------------------------------------------GYVRGEGCGVLLLKRLS-D--------------A--LKNKDKIWG-TII-TGTN--QDGHMAQ-------P---ISAPSGDQQERLLRDMYRR-H-NIDK-STVQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPTEANCLG-IFFG--------Q--D------------------------------------------------------------------GKTRHIGSVKTN-IGHLESAAGAAGLIKVLLMMKHETIVPSLF-SS-----K--LNPKIE-FEKYHLKVPT--DCV-PWEE--L-P--T-GGRAAGVNSFG-FGGSNCHAYVRQ------------------------------------------------------------------------------------------------------- 202 ------------------------VAVIGIGGRFP-G-A---IDVEEFWQLIL-NGNNPI-LEIQ-S--E-RL-AFKD--LYV----SDPNDPETK-RSYKAGLI-----K-R--LW-QWDNKLFSITDQ-EAEYIDPQQRCVLDCVHMAMEDAGLTR--------ADLDG--TKTGVFI---------------------------------------G-VMNDDF--KGIL-RE-----------A----A-A--ETSSYLVTGLNTSIISARVSYVFNLHGPS------MTIDTACSSSLVAIHQGALALRAGDCDMVICGGVNIILDP-MVFTTLSNARMLSPTGQCHSFTNKAD--------------------------------------------------------------------GYTRGEGCGIVLLKRTS-D--------------V--LRTGHKIWG-LLG-TGVN--QDGRMAT-------P---ITAPSGQQQISLLRQVYTS-F-NIPK-SSIQVIEAHG-----------------------------------------------------------------------T-GTAI------G------DPTECNALG-NFFH-EE--HA-P--T------------------------------------------------------------L--------RYIGSVKSN-IGHLESAAGIVGVIKVLLMMHYDTIVPSLH-VE-IE--G--IHPKNN-LIENGLTIPT--KPV-KWTV--P-N--G-GTKFACVNSFG-FGGTNAHAIVQECK----MN--Y-A------Q---E-RT---S-Q---------------FEM-----Q-------------------------L-------------------- 203 ------------------------VIISGISGRLP-E-S--N-NIAEFRENLI-NGIDMI-TE---NDR--RW-KPGL--------------Y--D-LPKRAGKLK--------ELDK-FDAAFFGIPPK-QADAMEPQLRMLLEVSYESLIDAGIDP--------YSIRGS--RTGVFI---------------------------------------G-ASESEA--HQAW-SA---D------------P--E-ATVGYHMTGCARSMFANRLSFYFDFKGP------S--------------------------------------------------------------------FVIDTACSSSLLAMDQALMSIRMGLCDAALVGGTSLCLKPTTSLQFKKLNMVSED-GCSKSFDASANGYVRSEAVVVIFLQKAK-N--------------A--KR----IYA-TLVHSKNN--ADGNKER-------G---ITFPSGEIQKKLITEVYSE-A-GVDP-KNVAYVEAHG-----------------------------------------------------------------------T-GTQA------------GDPQELNTIA-DVFC-K--G---R----------------------------------------------------------------D----G-PLLVGSTKSN-MGHPEPASGLAALAKVIIAMEDGMIPANLH-Y---K--E--PNPDIPGLLDGRLKVVT--ERL-RWNG-----------GYVGVNSFG-FGGSNVHALLRSY--P--TE--K------P-V----PHP--AS-D-------------------------M------ARLVTFAGRTEQAIS--E-------------------- 204 ------------------------VAIVGIACRFP-G-A---DNIDEYWKLLE-NGECHV-KKI-PD--D-RW-IVDE--IDV----K-EDDSWKP-CARHAGLI-----N-E--WD-KWDNKFFGISDT-EAAWMNPQQCMAIEVTHSALDNAGYTK--------EKMKG--TKTGVYI---------------------------------------G-IMNDDL--SSGL-I------------Y----A-RN-EFNNFLVTGIAGGITANRISYYYDLRGPS------IMIDTACSSALVATHLGCQAIRSGDCDMAICGGANSILTP-LKFIALSKAKMISPTGLSHTFSDKAD--------------------------------------------------------------------GYVRGEGCGILILKNLK-KARS----------------DGDKIWG-ILG-TGCN--QDGQSNV-------P---ITAPSSEQQKALLTEVYQK-Y-KVKP-GSIQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEMKALS-TFFG-PH--LK-S---------------------------------------------------------------G-----I-TVPVGSVKTN-IGHLESAAGAVGLIKVLLMMSHGKIIPSLH-YE-KD--N--ANPKID-FDKIPLVVAT--SVS-DWKA--D-A--E-DKRVACVNSFG-FGGTNSHAVLVQEH----E------------T---Y-DI--KT-----------------------------------------------------------------------N 205 ---------------------------------------------------LV-NGEDMV-TE---DDR--RW-EPGL--------------H--G-LPKRSGKLK--------DVTK-FDASFFGVNPK-QADAMDPQLRLLLEVTYEAIIDAGVNP--------QCVRGS--RTGVFI---------------------------------------G-VSASEA--HEAW-ST---D------------A--D-TTVGYCMTGCQRAMFANRLSFFFDFRGP------S--------------------------------------------------------------------YTLDTACSSSLLAMDQALLNIRLGLCDSAIVGGSSLCLKPQTALQFMKLGMLSPE-GACKSFDASGNGYCRSEGIVAILLQKRP-E--------------A--KR----IYT-TIIHSKNN--ADGNKEQ-------G---ILFPSGEQQKLLVKEVYRE-S-GVNP-SQVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNSIS-DVFC-P--G---R----------------------------------------------------------------S----K-PLLIGSTKSN-MGHPEPASGLAALAKVVIAMEDGMIPANLH-F---E--K--PNPDIPSLADGRLQVVT--ERT-QWPG-----------GYAAINSFG-FGGTNVHAVLESN----VMK--P-T----K-P----HVS---S-K-------------------------A------KRLFLGSSRTQEGLDQLM-------------------- 206 --------------------------------------------------------------I---DGG--KW----------------GN-M--G-CHQKNGKLK--------ELRH-FDAGFFGVHPK-QADCMDPQLRMLLEASYEAIIDSGQTL--------ESVRGS--RTGVYV---------------------------------------G-VSSSES--SDAW-TV---D------------P--E-TLVGYTMPGCCRAMFANRISYFFDFKGP------S--------------------------------------------------------------------FAVDTACSSSMICLDQALLNIRMGIIDAAIIGGCNLCLKLTTSLQFTRMGMTAPD-GHCKTFDASGNGYCRSEAVMAMYIQKSP-D--------------C--KR----LYA-TVVHTKSN--CDGYKEQ-------G---ITFPSGDLQKELIKEVYNE-I-GINP-LDVSYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQETNTIV-DVFC-K--G---R----------------------------------------------------------------K----E-PLLIGSTKTN-MGHPEAASGLTSIAKIIIAMEEKIIPPNLH-Y---H--T--PNPEIPGLTDGSLQVVT--ECT-RWNG-----------GLVSMNSFG-FGGANVHAIYRSH--D--KE--L-T------E----PHV--AS-Q-------------------------K------PRLFTCCARTEDGVRAIL-------------------- 207 ------------------------IAIVGVGCKFP-G-A---DNLEEFWRVLE-QGEDHV-QDIP-K--E-RF-NVDA--FYD----ENPDAAGKL-YMKKAGLV-----K-G--FH-EWDNQFYGIGDT-EAKQTDPQQRFVLDCVHMAFEDAGITK--------DDVNG--TDTGVYI---------------------------------------G-MMNDDY--KVAL-LG-----------Q----D--E-LINNYSVTGSHSSVISARVSYFYNLLGPS------LVLDTACSSALVAIHLAATAIKSGDISMAICGGVNCLINP-ETFISLSKARMASPSGKCQTFSKYAD--------------------------------------------------------------------GYARGEGCGIVILKKLS-K--------------A--VADNNKIWG-IIA-TGCN--QDGHTTS-------P---ITAPSSVQQMKLLEKVFNE-S-NVCP-STVQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEANTLG-TFFS-DR-----N--KG--------------------------------------------------------N--C-----S-SIHIGSVKTN-IGHLESAAGVAGLIKILLMMKNGKIVPSLH-SK-E------LNPKIT-FEKYGINVPQ--RIT-TWST--N-N--K-GEKVACINSFG-FGGTNSHAIVKEIK----QG--D-S------V---L-M--------NS------A-E-----------Q-T------LQIITLSANDSEA------------------------L 208 ------------------------VAIVGIGCKFP-G-A---NNIEEFWRVLS-EGEDHV-QDIP-I--D-RF-NVDA--FYD----ANPDAPGKF-YMRKAGLV-----K-G--FK-EWDNQFFGFGES-EASQIDPQQRFVLDCVHMSLEDGGITK--------QDIYG--TDTGVYI---------------------------------------G-IMNDDY--KVAL-MG-----------Q----D--E-LINNYTVTGTNTGVASARVSYLYNLLGPS------IVLDTACSSALVAIHLAASAIKSGDISMAICGGVNCIINP-ENFISLSKAKMASPTGKSQAFSKDAD--------------------------------------------------------------------GYARGEGCGIVILKSLR-K--------------A--LEDNNKIWG-TIC-TGCN--QDGRTTS-------P---ITAPSSSQQIKLLEKVFKQ-N-NVCS-STIQYIEAHG-----------------------------------------------------------------------T-GTSV------G------DPIETNALG-SFFS-RQ-----Q--ES--------------------------------------------------------R--N-----K-KIFIGSVKTN-IGHLESAAGVAGLIKILLMMEHGLIVQSLH-SE-E------LNPKIN-FQTFNFTVPH--LPF-TWQP--G-A--D-GERVACINSFG-FGGTNSHAIVKNIE----RK--S-K------T---G-K--------KS------T-A-----------Q-K------MQIVVLSANDSVSL-----------------------R 209 ------------------------IAIVGIGGKFP-G-A---KNCEEFWRLLK-NGENHV-KEIP-K--N-RW-DVDA--FYD----EDPGKAGKT-YVRRAGLL-----D-G--HD-EWDNKMFHISDA-EAERMDPQQRYTLDCVHMALEDGGIPR--------RDIHG--TDTGVYL---------------------------------------G-IMNDDY--KLGI-QG--------TSED----------RSNYAGTGSALSIAANRVSYVFNLNGPS------MCVDTACSSSLVAIHLGAQALRNGDCSMAICGGVNGILYP-DIFVSLSNSKMLSPTGQCQAFSENAD--------------------------------------------------------------------GYARGEGCGIVLLKKLS-K--------------A--IAEGNKIYA-VVY-TGIN--QDGQTVT-------P---ITAPSTEQQKALLKTVYKH-S-KIDP-GDIQYVEAHG-----------------------------------------------------------------------T-GTPR------G------DPVEANAIG-EFFG-SY--SS-K------------------------------------------------------------R--D-----K-KLKIGSVKTN-IGHLESAAGVAGLIKVLLMMANNSFVPSLH-S------Q-NLNSKID-FDMYGLEVST--STE-PWIS--E------GEEVACVNSFG-FGGTNSHAVIRKYT----PI--Q------K-S---E-T--------NP-----KA-A-----------K-C------RFPFVVSAEDKNSVR----------------------K 210 ------------------------IVIAGCASRLP-E-C---SNIAEFSHNLY-NRKHMV-ST---TEKAERY-EEG-------------Y-V--N-APVHLGSVP--------DLDK-FDASFFDMEKW-QVTRCDPQLRMFLERTYEAIVDAGESL--------ESLRGS--RTGVFI---------------------------------------G-SLPSDS--AEVG-RT----------------E--E-RMNKFSAYGYAYYHLSNRINYFFDFKGP------G--------------------------------------------------------------------MASDSACSSALAALENAVMQIRMGYLDYAIVGSTNLVMDPYASLTAVVVGMLCYD-GKCKAFDTRANGFSRADGNMILFLSKKE-L--------------C--KR----AYC-SVLHVRGN--SDGFTKE-------G---LAVPSGESQSQLLRNMYND-L-GMDP-NEVTYAEAHG-----------------------------------------------------------------------P-GTAV------------GDGIEADAIA-AVLCSN------R---------------------------------------------------------------K-----V-PLLLGTVKTN-MGHCEGSAGMASIIKTIIACEKKLLPPNLH-Y---E--Q--PNPNIKCLFDGRVKVIT--EAT-PFEK-----------GIASISSFG-VGGTNYNGVFRPY--K--NE--N-R------P---P-HP--AS-Q-------------------------T------PRLFVYGCRSEGTIGDVL-------------------- 211 ------------------------IVIAGISSRMP-D-S---ANIDEFTENLF-NKKHMV-TT---TEAAGRY-ENG-------------L-R--D-APMYVGAIP--------DADK-YDTTFFGMYPS-MAFACDPQSRMLLERAYEAVIDAGESW--------DSMRGS--RTGVFI---------------------------------------G-GYPSDS--PECG-RT----------------E--E-RMNGYTFIGYTHCHLANRISFFFDFKGA------S--------------------------------------------------------------------FSTDCGDGSGLCALEIAMTHIRLGNIDYAIVGSTNIVQDINSTVAGVNVGFYSFD-GKCRAFDANASGHCRADASVVLLLSKKE-V--------------A--KR----SYC-SVLHVRNS--GDGYTED-------G---FKAKSSEAQSKLLQNIYTE-M-GIDP-NKISFVEAHG-----------------------------------------------------------------------A-CNLE------------DDKMEAHALA-DVLCTN------R---------------------------------------------------------------K-----S-PLLVGSVNTN-MGHADGSAAMAGLVKSLIACERRMIPPSLH-F---E--T--PNPNIKALFDGRIKILT--EAA-PFEK-----------GLISINSFG-VGCTNYHATIRPN--E--IE--Q-R------E---P-HP--AS-K-------------------------E------PRLFVYGSRTEASAYKVL-------------------- 212 ---------------------------------------------------------------IP-K--E-RW-NTDA--FHD----KDKHAVGKS-YVQRAGLL-----K-D--PL-AFDNKLFNIMDF-EADQLDPQQRLVLECSYMAMEDAGITR--------QDLAG--SKTGVYV---------------------------------------G-AMNSDY--RSLS-SG-----------K----S--P-LVDCYTVTGITTSMIPARVSYVFDLRGPA------ILVDTACSSGLVAIHVAGQALKTGDCNLAFCGGTNFIMSP-DVFVHLSKANMLSPSGQVHTFSDKAD--------------------------------------------------------------------GYTRGEGCGMIILKRLK-D--------------A--ERDGNYVYA-TIK-TGSN--HDGHTVS-------P---ISAPSEEQQTMLLREIYDQ-S-GIEL-DSLEYIEAH-----------------------------------------------------------------------GT-GTPA------G------DPVEVNALG-KFFQ-SK---N----S------------------------------------------------------------V-----C-SRYIGSVKTN-IGHLESAAGIVGLIKVLLMMKHSKIVPSLF-FE-----K--PNPKID-FEGMKLKVPT--ELT-DWPT--Q-------EKIACVNSFG-FGGTNCHAIIKSV------------------------------------------------------------------------------------------------------ 213 ------------------------IAIVGIGCKVP-G-A---DNVEQYWKVLE-RGENHV-IEIP-K--E-RW-NNDA--FYD----TDPHAIGKS-YVRKAGLL-----K-D--PI-AFDNKLFNINDF-EADQMDPQQRFVLECSFMAMEDAGITR--------DKLAG--SNTGVYV---------------------------------------G-AMNGDY--RGLF-TA-----------K----S--P-VVGNYTVTGISNSIIAARVSFTFDLRGPS------MTLDTACSSALLAIHIGAQALRSGDCDMALCGGTNFLMSP-DVFVHLSKAHMVSPTGQCFAFSDSAD--------------------------------------------------------------------GYTRGEGCGMVILKRLK-D--------------A--LKDGDRVWA-TIE-TGSN--QDGHSVT-------P---ISAPSGDQQIKLLQHVYKN-A-QVDL-NRIDYIEAHG-----------------------------------------------------------------------T-GTSA------G------DPVEANALG-KFFQ-DN---G----A------------------------------------------------------------V-----R-HRYIGSVKTN-LGHLESAAGTAGLMKVLLMMKHSKIVPSLF-FE-----R--PNPKID-FPNMNLTVPT--EVV-DWPT--Q-------NKIACVNSFG-FGGTNCHALVMAYE----DH----M----S-R---Q-TS---------MV----------EDQ-----N-I------PCIVCFSAKHEKSL---K-------------------- 214 ------------------------VVISGISCRLP-Q-S--D-NMEELRQNLI-HGVDMV-TG-S-DE------------------------N--R-FSKRRGVLK--------DITK-FDASFFGIPPK-QADVMDPQLRLLLEVTYEAFIDAGIDP--------HKFRGS--RTGVFI---------------------------------------G-LGISEA--HEGW-GS---D------------P--D-KPRGYAAWGCTKNMFANRVSFTFSLKGP------S--------------------------------------------------------------------YAMQGSDAASALALDHALHSMHNDNCEAALVGGVNLCLKQTSDIQYLKLGVLSSD-GNCKPFDSSANGYCRSDGVVALLLQKRS-Q--------------A--KR----IYA-TILNTKNI--TGQNQGT-------G---PAYPSVSLQMQLLSEIYQE-A-GVDH-TYVEYIEANA-----------------------------------------------------------------------I-GHKM------------LDAQEVLALS-KVFC-R--K---S----------------------------------------------------------------G----S-RLLIGSVKSN-LGHLEAASGLGSVAKVIVALEDGMVPANLH-Y---K--S--PDPNMAAIVNGKLHVVT--ENT-RLYG-----------QIYGINTLG-LGGIHVHTILKAD--S-KRP--K--------W----RHP--AA-G-------------------------K------MSLFVYAAHTPAGVQ--S-------------------- 215 ------------------------VAVVGLGCRFP-G-A---NDKDEFWRLLE-NGENHI-IDIK-D--N-RP-GFDS--SYV----TDPNDPGLR-RAYRAGLV-----E-R--FS-NWDNHVFSIKDD-EAKWIDPQQRFVLDCVHMALEDAGITR--------KELDG--SNTGVYI---------------------------------------G-AMNDDF--KNVI-LE-----------D----Q-DN-EDSSYRVTGLALSMISNRVSYVYNLHGPS------MNIDTACSSSLVAIHQGSLALKAGECDIAICGGVNLILDA-RVFVSLFSSGMLSPTGQCHSFSSKAD--------------------------------------------------------------------GYTRGEGCGIVILKRVQ-N--------------A--VEHKNKIWG-LVG-TAIN--QDGHEAT-------P---ITAPSGKQQLALLEKVYKE-Y-NVLR-SSVQVIEAHG-----------------------------------------------------------------------T-GTPI------G------DPVEANALG-TFFY-TT--HS-S--T------------------------------------------------------------T--------KYLGSVKSN-IGHLESASGVAGLIKVLLMMKNRNIVASLH-VK-EE--G--ITMRTN-IEQYGLTIPT--ETV-NWLC--D-D--T-KARTACVNSFG-YGGTNAHAVVREHK----IT--K-H------L---Q-NS---S-P---------------GTK-----T-E------PVIIVMSATSNYALH--A-------------------- 216 -----------------------------------------------------------------------RW-PPG---VYG--------------LPPCIGTIY------D--IDK-FDSKFFQITE-FEANHMNPMLRHVLEVVYECIIDSGLTY--------HELQRE--RTGVYL---------------------------------------A-VFGSDM--DLL-ET---------------------SRC-NNMEHVSLSSFMCGEVMRQFRLTGPT------ATVDTACSSSIAALDIAVTDLKQGRCKYAIVASSNLILYP-QFSQQMFVLNMLSPKGQSLVFDKDAD--------------------------------------------------------------------GYVRAEGVAAILLTREA-E---------------YFRR----VYAS-VVDVGIN--CDGYKMD-------G---ITNPSRESQVSLMRELYT-R-SMIDL-EAVKYVEAHG-----------------------------------------------------------------------T-GTQV------G------DTTELGGLA-DVFC-KN--R------------------------------------------------------------------S-----V-PLLVGSVKSN-MGHSEATAGLASIIKCVLALQRKMLPPNRN-FN-----T--PNPKIDAIIDWRIRVVD--KPT-PLKS----Q-------YVGVNCFG-FGGVNGHVILEPYQ----DQ--F-R------E---D-FV--P----VS----------------------R------HLLVPVTGRTEDCMQQTW-------------------- 217 ------------------------VAIIGVGCRFP-G-V---NNLDEFWNVLK-HDEDHM----P-G--N-KR-NA---------------------------E-------S---HA-EWDYKVYSIIED-QTLEMNVQQRCVLNSTYMALENAGITK--------QQLNN--SNTGVYI---------------------------------------G-MVNTDC--NSNN-AH-----------C----S--R-GLNEYKIASNQKQTVASMLSDVFNLHGPS------ITVDSGSFPSLMAIQQAHQAVRSRKCDIAISGGVTVLND---------------------------D--------------------------------------------------------------------GCTRGEGCGIIILKSLE-K--------------A--QEDNDPLWG-TIS-TSSD--HDSQSKP-------S---NTRPSLDEQVEMLDLFFKR-H-HIDV-ETIDYIEAQS------------------------------------------------------------------------TDMET------Y------DAVEVTALM-TFFQ-KI---G-K-----------------------------------------------------------------------TRTIGSVETN-TKQLESTVGLAGLIKILLMHKYQKVVPSPN-FE-----Q--ACEYVT-LNKYTFMVPE--KTT-NWPE--N-D--K-GYSRSYLNSFCHFCRFNCHVVVTT------------------------------------------------------------------------------------------------------- 218 ------------------------IVVVGVGCRFP-G-A---DNVEEFWRVLL-NGENHV-IEVP-P--D-RW-NANH--YYD----PDKNTPGKM-YVKQAGFI-----P-G--FE-EWDNVHFGISDE-EAQTMDPQQRIVLQCVDMAAQDGGFTR--------LDLQK--GTTGVYI---------------------------------------G-SMTYDY--NIQG-TD-----------DV------L-ALGTYSVTGSHSSIISARVSYVYNLTGPA------LTIDTACSSSLEAVHLGSQALLTGDCDTAICGGVNYLLEP-NLFVALSKARMLSPTGQCKAFTRDAD--------------------------------------------------------------------GYVRGEGCGIVILKRLK-D--------------A--QRDGNKIWG-LVQ-SGTN--QDGQHAQ-------P---ITKPAQDQQQKLIKQIITK-F-HIDT-SKIRVIEAHG-----------------------------------------------------------------------T-GTPV------G------DPVECNALG-TVLG-SK--D------H-------------------------------------------------------------------KKFIGSVKTN-IGHLEAAAGVAGLIKVLLMLKHKIIVPSLW-YR-TE--N--ENPKLR-LSEHGFIVPT--NCE-QWIA--D-K--N-AVRIACVNSFG-FGGTNVHVVVNEVT----TA--N------S-D---S-KT------------------C-TS-------I-I------PPIVAVTARDQET------------------------L 219 ------------------------IAVVGMGCRVP-G-A---DNIEEFWKVLL-NGENHI-TDIP-K--E-RW-HNDA--FYS----EDQDEPGKS-YARKAGFI-----N-C--YD-EWDNKFFGISDH-EAARIDPQQKLVLECTHMALEDAGITK--------EQLKG--TPASVYI---------------------------------------G-AMNDDY--KNLY-MF-----------D----H--D-EDTSFSATGMSTTLISARVSYEYDLRGPS------MVVDTACSSSMSAIHLGSQSIRSGECEMAICGGVNCIIIP-DQFITLCKSKMLSPSGQCQSFCDTAD--------------------------------------------------------------------GYCRGEGCGIVILKSYK-K--------------A--LEDKNKIWG-IVK-TGSN--QDGQMAK-------P---ITAPSGEQQEELLKKVYSL-Y-NIDP-VSLQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPTEINAIG-KFIK-SY--R---------FKIVNNKQ--N-------DTNDFR---RLENDFQNS--ESKSKTENNDLF-QDNA--I-----E-SILIGSVKSN-IGHLESAAGVVSLIKVLLMMNERKFVPSLH-VK-KDKSN--VNKMIN-LESSGLDICT--EVS-EWKP--D-P--D-GKKICCVNCFG-FGGSNMHAVVIQQD----MK--E-R----Y-----N-HA--DN-Q-YK---IV-------------------------CSSG-L--NEANL---K-------------------- 220 ------------------------IAVIGIGCRFP-G-A---DNIDEYWRVLV-NGENHI-TDIP-K--E-RW-NNDA--FYS----ENKDEPGKS-YVKKAGFT-----S-G--YD-EWDNKLFGVSDS-EAKHIDPQQRQVLECTHMALENAGLTR--------QKLRE--TETGVYI---------------------------------------G-VMNDDY--KVLS-SF-----------D----H--E-EDTNYSATGMSSTIISARISYVYDLRGPS------MVVDTACSSSMLAIHLGSQAIRSGDCTMAICGGVSSILIP-DQFITLCKARMLSPSGQCKSFCDTAD--------------------------------------------------------------------GYGRGEGCGIVILKSYT-Q--------------A--LKDKNYIWG-IVK-TGSN--QDGRVAQ-------P---ITAPSGQQQEELLKKLYYL-Y-QIDP-ASLQYIEAHG-----------------------------------------------------------------------T-GTPI------G------DPTEINAIG-RFIQ-SH--R---------TKFTIDTQ----------NETKHHQGAS--------------------SR-SVKI--N-----E-TILFGSVKSN-IGHLESAAGVAAMIKVLLMMKYGKYVPSLH-VK-KDKSN--INKKIA-LETYGLDISL--DLS-DWNP--N-A--K-EERICCVNCFG-FGGSNTHAVVIQN------------------------------------------------------------------------------------------------------ 221 ------------------------IAVIGIGCRFP-G-A---DNIDEFWRVLV-NGENHV-VDIP-P--E-RW-NNDA--FYS----DDPDKPGKY-YARKAGFL-----N-R--HD-EWDNSLFGISDS-EAVRIDPQHRYVLECTHMAMEDGGITR--------KHISG--TKTGVYI---------------------------------------G-AMNDDY--KSLS-NL-----------D----H--D-EDTNYTATGMSSTIIAARVSYVYNLCGPC------MVVDTACSSSITAIHLASEAIRSGECEMAICGGVNSLLCP-DVFITLSRAKILSQIGQCQTFCDSAD--------------------------------------------------------------------GYARAEGCGVVIIKSLK-K--------------A--LQDKNKLWG-IVR-IGIN--QDGRSVQ-------P---ITTPSGEQHEELFKEVYTR-Y-DVNP-SRIQYIEAHG-----------------------------------------------------------------------T-GTRV------G------DPTEVNALG-NFIR-NW--N----------------------------------KGTVHKKKSKEEIEQSSNG--------YQE--N-----E-KILIGSVKTN-IGHSESAAGMSGLIKVLLMMKYGSYVPSLH-IR-KDKSN--LNKNIK-LDEYGFDIAM--ETE-EWRT--N-E--N-GMRICCVNSFG-FGGSNSHAIVIQIP----QQ--T-P----R-----N-QN--ST-E-SN---LW-------------------------FPICVS----------T-------------------- 222 ------------------------VVISGVSCRLP-Q-S--D-NMEEFKENLM-GGVDMV-TE---DDS--RW-KPGL--------------Y--G-LPKRSGKLK--------DLSK-FDASFFGVHPK-QANSMDPQLRILLEVTYEAIVDAGINP--------EDIRGS--KTGVFI---------------------------------------G-ASASES--HDAW-SM---E------------V--E-NTVGYAMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLLALDQALHSIRSGQCDAAIVGGANLCLRPAVAVQFMRLGMLSPK-GMCKSFDAEGNGYCRSEGIVAVYLQKEV-G--------------A--KR----VYC-TLVHSKTN--SDGNKQQ-------G---ITFPSGDVQKRLLNEVYSE-A-CIDP-TKMSYIEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIC-DVFC-K--G---R----------------------------------------------------------------K----G-PLPIGSVKSN-MGHSEPASGLAAVAKVIVAMEESTIPGNLH-Y---S--S--PNQDIPGLINGKLEVVD--HNK-KCDV-----------GLVGVNSFG-FGGSNVHTILRSN----KFN--G------M-S----VCE--GC-E-------------------------K------KRLFLYSSRSEEGLKEI--L------------------ 223 ------------------------VFVAGIAARLPQ--S---ENIDVFWENLI-KGNDMI-G-------QTRW-PKE---LYG--------------TPPRVGLIK------N--LD-KFDADYFNFEE-TEVHHMNPMLRHLLEVCAECIVDSSLCP--------PVLQNN--STGLYL---------------------------------------A-CFLPDN--DPL-ET---------------------SRG-ANSRLCTTVPTLAGHLMEHFGLSGPM------LTVDTGCSSSLSAMEMAVNDLRAGKCQFALVTAVNLLLNP-SYLQQMSQLGMLNPTGQSNVFDAKAG--------------------------------------------------------------------GYVRAEGVVSILLTRNE-S---------------ICKR----VYLS-IVDIMTN--CDGFKSE-------G---ITFPNSQSQADLMNKIYN-R-CKIDV-NNISYVEAHS-----------------------------------------------------------------------T-GTKA------G------DPVEVAGIC-EALC-KN--R------------------------------------------------------------------Q-----K-PLLIGSVKAS-MGHSEATAGFASFVKCVLIARHGTIPPQIN-FQ-----S--PNPNIKGILEGKVKVVD--KAT-ALED----G-------YISLNSFG-YGGANGHLVLKPYR----N---H-C------S---N-Q--------AT----------------------S------HKLVTIKARNELEMETIV-------------------- 224 ----------------------------------------------------------------------------GL--------------Y--G-LPKRSGKLK--------DLSK-FDAAFFGVHPK-QAHRMDAQQRMLLEVTYEAIVDAGVNP--------DTLRGS--KTGVFI---------------------------------------G-ASASES--HDAW-SG---D------------P--E-STVGYTMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------YTIDTACSSSLLALDQALQSIRSGQCDSAIVGGSNLCLNPMSALQFLKLGMLSPD-GMCKSFDAEGNGYCRSEGIVALFLQKES-H--------------A--KR----IYC-TVVHSKTN--SDGNKQQ-------G---ITFPSGLVQKRLLTEVYSE-A-CIDP-ATVSYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIA-DVFC-K--G---R----------------------------------------------------------------Q----G-PLLIGSIKSN-MGHSEPVSGLAAVAKVIIAMEEQVIPRNLH-Y---K--T--PNTDIPGLVSGQLEVVT--EKR-CWTG-----------GIVGVNSFG-FGGSNVHAVLKSN----SRS--T-DQDICK-K----AED--LQ-K-------------------------Q------KQLFLYSSRTEEGLKSM--M------------------ 225 ------------------------IAIIGVGCMFP-G-A---RNLAEFWDVLS-NGEDHV-KEIP-P--E-RF-SVDA--FYD----ADPNAPGKS-YVRKAGLL-----T-G--HN-EWDNHYFGVSEY-EALHMDPQQRYVLECVQMAMEDGGITR--------KEMDG--SNTGVYI---------------------------------------G-AMNNDF--RSYT-DG-----------D----N--T-LVSNYTVTGISPSIISARVSYFYNLLGPS------MTLDTACSSSLVAIHTAATAIKSGDIDMAVCGGVSSILNP-EMFICLSKARMASQTGHCHAFSSMAD--------------------------------------------------------------------GYARGEGCGIVILKRLK-E--------------A--TDDGNKIWA-TIL-TGCN--QDGRTNA-------A---MSAPSQSQQERLLESIYLK-R-GIDP-RLVQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPVEANALG-CFFR-KY--LN-E------------------------------------------------------------K--D-----S-AIKIGSVKTN-IGHLESAAGVAGLIKVLLMMRHNTIVKSLF-SE-S------LNPNIP-FEKYKLEVVK--SKC-KWPN--I-L--N-SQQLACVNCFG-FGGTNTHAVLQKFS----KT--E------S-L---L-KK-----S--K---CNDH-G-----------I-F------SKIITFSAESPDS------------------------L 226 ------------------------VVISGISGRLP-E-S--D-NLEEFRQHLM-KGEDMV-TE---DDR--RW-QPGL--------------H--G-LPRRNGKLK--------DLSR-FDAAFFGVNPR-QADALDPQLRLLLETCYECILDAGVDP--------QTIRGS--KTGVFI---------------------------------------G-ASFSES--AEAW-AS---D------------T--S-KTIGYTMTGCARAMFANRLSYFFDFKGP------S--------------------------------------------------------------------FVLDTACSSSLLALDQALHSIRNGHCDAAIVGGSGLLLKPGTSLQFLQLGMLSPD-GKCKSFDASGDGYCRSETVGTIFLQKAA-D--------------A--KR----VYA-TVVHSGTN--ADGNKEQ-------G---ITFPSGEAQKALLLEVYRQ-A-GIPP-SSVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIA-DVFC-K--D---R----------------------------------------------------------------Q----G-PLMIGSTKSN-MGHPEPASGLAALSKVVIAMEEGVIPPNLH-Y---D--S--PNPDIPALQDGRLAVVT--QCQ-PWQG-----------GYVGVNSFG-FGGANVHALLKSN--P--KE--R------E-C----PHP--DA-N-------------------------S------LRLLTYCGRTEEGVQRVL-------------------- 227 ------------------------VVISGISCRLP-E-S--D-NIDEFKENLM-NKVDMV-TE---DDR--RW-KPGF--------------H--G-LPRRNGKIK--------DLSR-FDATFFGVSPK-QANAMDPQLRMLLEVTYEAIVDAGTDP--------RSVKGS--RTGVFI---------------------------------------G-VSVSEC--QDIW-SS---V------------S--D-NVEGYVMTGCSRTMFANRLSFFFDFKGP------S--------------------------------------------------------------------YSMDTACSSSLLALDHALASIRSGACDAAIVGGTNLCLNPAISLQFMKLQMLSPG-GACKSFDASGDGYVRSEAVVAIYLQKAS-D--------------A--KR----IYA-TVVHSKNN--CDGNKSQ-------G---ITFPSGAIQKQLMQELYSE-A-CVDP-LGVSYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNALT-DVFC-K--D---R----------------------------------------------------------------K----G-PLLIGSVKSN-MGHAEPASGLAALSKVLIAMNTGLIPPNLH-F---S--E--PNPDIPSLMDGRIQVVT--ECM-PWSG-----------EYAAVNSFG-FGGSNVHILLRSK----KKK----------------------------------------------------------------------------------------------- 228 --------------------------ISGVGCRLP-E-S--D-NIAEFRDHLM-NGVDMV-TE---DDR--RW-PPGL--------------Y--G-LPRRSGKLK--------DITK-FDASFFGLSPR-QTNNMDPQLRILLEVTYEAVVDAGMSP--------YSMRGS--RTGVFV---------------------------------------G-CSASEA--FEAW-SA---D------------A--D-NIEGYTMIGCQRSMFANRLSFFFNFRGP------S--------------------------------------------------------------------YTLDTACSSSLLALDQALLSIRLGYCDAAIVAGCSLCLKPQSAQQFNKLSMLSDY-GACRSFDASGAGYCRSEGVVAVLIQKIS-V--------------A--NR----LYM-TVVHSKNN--ADGAKEQ-------G---ITFPSGEVQESLIREVYRD-A-GIEP-RIVAYIEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNAIA-SVFT-V--G---R----------------------------------------------------------------N----K-PLLIGSTKSN-MGHPEPASGLAALCKVIISMESGIIPANLH-Y---V--N--PNPEVPALLDGRLAVVA--EHT-LWDG-----------GIVGINSFG-FGGANVHAILESN--A--LS--T------H-A----WHE--GS-G-------------------------D------IRLCVTSGRTETGVNGMI-------------------- 229 ------------------------VAVIGIGCRFP-G-A---NDKEEYWRLLL-NSENHI-VEVK-S--H-RS-GFDN--HFI----TDPLDAEIK-QPYRAGLV-----E-R--FA-CWDNKVFGITEQ-EAEWIDPQQRFVLDCTHMAMEDAGLTR--------RDLDG--TNTGVYI---------------------------------------G-VMNDDF--KCTV-LR-----------N----L-D--SGSSYLVTGINSSIISARVSYVYNLHGPS------MTIDTACSSSLVAIHQGALALGAGDCDMAICGGVSLLLDP-TLFKTLSNARMLSPTGQCHSFTSKAD--------------------------------------------------------------------GYTRGEGCGMVILKRVE-D--------------A--VKCGNKIWG-FLG-TGVN--QDGHMAT-------P---ITAPSEQQQIALLHHVYKK-Y-HVLK-STIQVIEAHG-----------------------------------------------------------------------T-GTPL------G------DPTECNALG-TFFK-EE--NS-S--S------------------------------------------------------------L--------KHIGSVKSN-IGHLESAAGVAGLIKVLLMMHHEQIVPSLH-VD-KE--G--VNERNN-LGKNGLVIPT--KLC-KWPL--P-D--G-VPRMACVNSFG-FGGTNAHAIVQEYI----KI--P-----------------------------------------------------------------------E-------------------- 230 ------------------------VAITGISGRLP-E-S--E-NIAEFREKLI-QEIDMV-TE---DER--RW-PIGL--------------Y--D-LPKRSGKLK--------ELDK-FDAAFFGIPPK-QADAMEPQLRMLLEVAYESIVDAGFDP--------HSLRGS--KTGVFV---------------------------------------G-ASESEA--HQAW-SS---D------------P--E-TTVGYHMTGCARSMFANRLSYYFDFKGP------S--------------------------------------------------------------------FVMDTACSSSLLAMDQALASIRLGLCDAAIVAGTSLCLKPTTSLQFKKLNMVSTD-GCCRSFDASGSGYVRSEAVVVAFLQKAK-H--------------S--RR----IYA-TLLHSKNN--ADGNKEQ-------G---ITFPSGEIQKRLLTEVYQE-A-GIDP-KNVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQELNSIT-DVFC-K--G---R----------------------------------------------------------------E----G-PLLIGSTKSN-MGHPEPASGLAALAKVLIAMEDGMIPSNLH-F---K--D--PNPDVPGLLDGRLKVVT--ERL-QWNG-----------GYVGINSFG-FGGSNVHALLRSY--P--NE--K------E-T----SHP--AS-E-------------------------L------PRLVTYAGRTQEAVGTML-------------------- 231 --------------------------IGGIACRLPK--S---ANVEIFWQNLI-DKVDML-D--R-T----RW-PVG---IYN--------------LPPRTGTLE------D--VE-DFDNDFFGLSI-AETAGIPCMLRLLLEVIYECIIDSGIPR--------KTLSKS--RTGLYL---------------------------------------A-INFCED--QEI-NR---------------------G-T-DSSFYMNTKSEFIYRIFSILDLSGPA------ASVDTACCSSISAIQMANMDLYLGRCDYAIVVGANMLENL-NHAIQFFKLGMLSPSGQSLPFDTKAN--------------------------------------------------------------------GYVRSEGFVAMLLSS-S-S---------------LLNR----IYAK-IDNVVCL--CDGYKER-------G---ILSPSEKDQINLLKKAYL-D-R------YPVYVEAHA-----------------------------------------------------------------------T-GTQL------G------DETELKSLK-EAFG-DK--L------------------------------------------------------------------K-----E-PLLIGSCKSN-LGHTEACAGLVGLLKCVLSIHHGVIPPNIN-LM-----S--PHPLLTES-KPWAKVVT--QET-KLPD----G-------YIGVSSFG-FGGVIGHVVLEKLP----EK--I-A------N---V------------------------------------------------------------P------------------ 232 --------------------------IVGLGCRYP-G-A---DNLQEFWKLLC-TGEDHV-NEIP-K--E-RW-NNAA--FFD----EDPDARGKT-YVTKCGFI-----E-D--IN-GFDNTLWGISNT-EAQKMDPQQRLVLECTHMAFEDGGFTR--------KYLDG--SKTGVYM---------------------------------------G-TMTDDY--RNMY-AD---------------AY--E-DMSVYSLTGMSGSIISNRVSYTYNLHGPS------ITLDTACSSGLVAIDVASLALRRGDINLAVCGGVNVLQLP-YINMALCRARMLSRTGKCHTFSADAD--------------------------------------------------------------------GYARGEGCGVVILKKLK-QA----------------RCDNDKIWG-TIA-TQCN--QDGRMAT-------P---ITAPSGEQQKQLLELIYPA-S-NIDA-ALIQYIEAHE-----------------------------------------------------------------------TIGMVV------DSLIEHFDQVDNSKTG-DAMQ--PGIAE-GRTR------------------------------------------------------------D-----SPLLTVATAGGETNGFQKGTI-LRYIGNESNGDQERTAYSLLTPFL-----A--PIPTKRKLQKNRPNLKE--SFL-KMLP--N-------GMLHTVSVIL-EGGNN-------------------------------------------------------------------------------------------------------------- 233 ------------------------VVISGLACRLP-E-S--D-NIAEFREHLV-NGEDMV-TD----SR--RW-PPGL--------------Y--G-MPERCGTIK--------DISK-FDASFFGVHPK-QADSMDPQLRLLLEVTQEAIVDAGVNP--------QSIRGS--KTGVFI---------------------------------------G-TSASEC--HEAW-SC---D------------P--E-TTVGYSMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------FAIDTACSSSLLALDQALFNIRAGRCDAAIVGGASLCIKPTTALQFMKLGMLSPE-GMCKSFDESGNGYCRSEGIIAIYIQKLP-E--------------A--RR----VYS-TILHAKNN--ADGNKEQ-------G---ITFPSGAIQKKLLNEVYSE-A-AVDP-SSVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIA-DVFC-K--G---R----------------------------------------------------------------Q----E-PLLIGSTKSN-MGHPEPASGLAAVCKVIIAAEDGMIPANLH-Y---K--N--PNPDIPGLVDGRLKVVA--QRT-KWDG-----------GKVGVNSFG-FGGSNVHVLMET--NTK--P--H------A-E----KHS--AC-E-------------------------S------RRLFLNSSRTQEGLENIL-------------------- 234 ------------------------VSVSGISCRLP-E-S--D-NMEELRQNLL-NSKDMV-TD----YR--RW-DPGV--------------Y--G-LPKRCGTLK--------DISK-FDAIFFGVNPK-QADRMDPQLRILLEVVYEAIVDAGVNP--------DEVRGS--KTGVFV---------------------------------------G-SIGSEA--HIAW-SA---N------------K--D-TIDPYTMTGCAGAMLANRLSFFFDFKGP------S--------------------------------------------------------------------VVLDTACSSSLTALNEAFRSIRTGDCDSAIVAGANLILKPSTSMEFQKLGMLSPE-GMCKSFDEEGNGYCRSEGIVAIYLQKTS-Q--------------A--KR----TYC-TILHCKSN--ADGYKEE-------G---VTFPSRHMQKQLIREVCEE-A-GVSG-TDIVYMEAHG-----------------------------------------------------------------------T-GTRA------------GDPQEAGAFA-DLLC-D--GR-------------------------------------------------------------------K----E-PLLIGSIKSN-LGHTEPVSGLAALAKVVIAMEVGYIPANLH-Y---N--T--PNPDIPALQDYRLKVVT--ETT-KLPQ-----------GIVGLISFG-FGGSNTFALLVPA--V--PP--R-E------QS---LLE--QR-H-------------------------P------RRLFTCSWRTEEGLNNIL-------------------- 235 --------------------------INGVSCRLPQ--S---DNVKEFWDNLI-NGVDMI-G-------PTKW-PVG---LHG--------------LPPRSGNLK------N--VNK-FDFEYFGLVE-GECDMRNPMLNCLLEVTYEAIVDSGLHL--------SQLQQT--SVGYFL---------------------------------------G-CTFADM--DAV-LT---------------------SQK--QSVLDQTRPYFISNIMKAFDLTGPG------LGVDTACSSSVYALQLAVTSLMAGRCQYAFVAGSNMILNP-NISLQFHRLQMLSPTGMSCAFDESAN--------------------------------------------------------------------GYVRSDGIVVMLLSRSD-V---------------TCPR----IYAS-IVDVGTN--CDGHKDE-------A---VIFPSKAGQKLLLTDMYN-K-NKIKV-QDVFYVEAHG-----------------------------------------------------------------------T-GTQA------G------DLVELTAMS-DVFC-VD--R------------------------------------------------------------------E-----Q-PLLVGSVKSN-IGHCESAAGLAGLLKCVLSIHHKTVPPNLN-FN-----K--PNPKIAPLTDGRILVVD--VPT-PLED----K-------LIGVSSFG-FGGANGHIILKPYN----NE--R-R------S---Q-IE--V----P-----------------------S------YIMLPVMARDPDGFTKI--------------------- 236 --------------------------ITGVSCRLPQ--S---DNVKEFWDNLS-SGVDMI-G-------PTKW-PVG---LHG--------------LPPRTGNLK------N--TNK-FDFEYFGLIE-AECDMRNPMLNILLEVTYEAIVDSGLHL--------RHLQDS--TVGYFL---------------------------------------G-CTFSDV--DAV-LT---------------------SQK--QPVFDQTRPYLVSNVMKAFNLMGPA------LAVDTACSSSIYAIQMAVMNLAAGRCQYAFVAGSNLVLNP-NMSLQFHRLQMLSPTGTSSAFDESAD--------------------------------------------------------------------GYVRADGVVVMLLSRAD-V---------------QCPR----IYCS-IVDVATN--CDGHKDE-------A---VIFPSQVGQKSLLTEIYT-R-NKINV-KDLFYVEAHG-----------------------------------------------------------------------T-GTQA------G------DLVELTAMS-DIFC-VD--R------------------------------------------------------------------E-----Q-PLLVGSVKSN-IGHCESTAGLAGLLKCVLSINNRVIPPNLN-FN-----T--PNPKIQALVDGRILVVD--VPT-PLED----K-------LIGISSFG-FGGANGHVILKPYY----HS--S-P------M---E-IT--V----P-----------------------K------YIMLPVMARDLEGFNKI--------------------- 237 ------------------------IAIVGIGCRFP-G-A---NNIDEFWEVLK-NGEDRV-IRIP-R--D-RW-NVDA--FYD----PDPDAPGMT-YTKYAGII-----E-G--FE-SWDNNFFGISDS-ETETMDPQQSIVLECTHMALENAGIRK--------TDING--SRTGVFI---------------------------------------G-CMNMDY--NAQL-CK-----------TSGPEE--S-IANSYTLTGNGNSVISARVSYIYNLLGPS------MNIDTACSSSLVAIHQGCLGIKSGDCDMAICGGVNYILSP-ELLVTMSKSRISSLTGRCHTFSADAD--------------------------------------------------------------------GYTRGEGCGIVILKRHS-DA----------------IKDGNTIWG-VIA-TGCN--QDGHMAT-------P---ITAPSGEQQLRLLREVYSK-H-NIDK-GRIQYIEAHG-----------------------------------------------------------------------T-GTPR------G------DPIEVDSLG-QHFT-SD--SP----I--------------------------------------------------------------------TKYIGSVKTN-IGHLESGSGVAGLIKVLLMMEHGLIAPNLH-FK-T------PNPRID-FDAFKFKVPT--SCI-KWQP--G-S--D-GKRLACVNSFG-FGGTNAHMVIERKE----ER--H-D------L---V-SS--KN---------------------------D------KHLVVFSAPSNDAL---I------------A------- 238 --------------------------MSGVGCRLP-E-S--D-NIEEFRDHLM-NGDDMI-TE---DDR--RW-EPGL--------------F--G-LPKRAGKLK--------DVTK-FDAAFFGLSPR-QTNNMDPQLRLLLEVTYESMIDAGVSP--------NEMRGT--RTGVFV---------------------------------------G-SSTSES--HEAW-SI---D------------A--E-NVDGYTMIGCQRSMFANRLSFFFDFKGP------S--------------------------------------------------------------------YTMDTACSSSLLALDQALLSIRLGYCDAAIVAGCSLCFKPQTSQQFHKLSMLSEY-GACRSFDASGAGYCRSEAVVAVFLQQVS-V--------------A--NR----IYM-TVVHTKNN--ADGAKEQ-------G---ITFPSGEVQAKLVREVYRD-A-GIEP-RNVAYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNAIA-DVFC-T--G---R----------------------------------------------------------------R----S-SLLIGSTKSN-MGHPEPASGLAALCKIIIAMETGVIPANLH-Y---N--T--PNPEIPALIDGRLKVVA--ENT-EWKG-----------GIVGINSFG-FGGSNVHAILESN--S--LR--H------K-H----WHD--GA-G-------------------------D------RRLSIASGRVEEGVRRQL-------------------- 239 ----------------------------------------------EFRDHLM-NGDDMV-TE---DNR--RW-EPGL--------------F--G-LPKRSGKLK--------DITK-FDASFFGLSPR-QTNNMDPQLRLLLEVVYEAIIDAGVSP--------YRLRGT--RTGVFV---------------------------------------G-VSSSEA--HEAW-TA---D------------S--E-NIEGYTMIGCQRAMFANRVSFFFDFRGP------S--------------------------------------------------------------------YTMDTACSSSLLALDQALLSIRLGYCDAAIVAGCSLCLKPQTAQQFHKLSMLSDY-GACRSFDASGAGYCRSEAIVAVLLQQIS-V--------------A--NR----IYM-TVVHSKNN--ADGSKEQ-------G---ITFPSGAVQECLIREVYRD-A-GIRP-QDVAYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNGIT-NVFC-S--D---R----------------------------------------------------------------D----Q-PLLIGSTKSN-MGHPEPASGLAALCKIIIAMESGIIPANLH-Y---R--T--PNPEIPGLLDGRLKVVA--ENT-PWSG-----------GIVGINSFG-FGGANVHVVLESN--S--LH--T------K-Q----WHE--GA-G-------------------------D------HRLSIASGRTEAGVSSML-------------------- 240 ------------------------VVISGISCRLP-E-S--N-NMEEFRQNLF-NGKDMV-TA---DDR--RW-PTGM--------------Y--G-LPERSGKLK--------DLDK-FDASFFGVHPK-QANTMDPQLRIMLEVVHEAIVDAGVNP--------DMLRGS--KTGVFI---------------------------------------G-ASASES--HDAW-TR---D------------V--D-KTVGYSMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------YAMDTACSSSLLAMDQALHSMRRGHCDAAIVGGCSLCLNPLTALQFLKLGMLSPQ-GTCKSFDAEGNGYCRSEGVVAILLQKSH-S--------------A--KR----IYS-TVLHSKTN--SDGNKDQ-------G---ITFPSGQVQKTLLQEVYSE-A-CVDP-TSVAYIEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIA-DVFC-K--D---R----------------------------------------------------------------Q----G-PLLIGSTKSN-MGHPEPASGLSAVAKVIISMEDGQIPANLH-Y---N--N--PNPDIPALTDGCLQVVT--ERT-HLKG-----------DIVGINSFG-FGGSNVHTLLKAS----ENK--N-S------T----VHP--DC-K-------------------------S------RRLFVYPGRDIEGLESVL-------------------- 241 ------------------------IAIIGVGGKFP-G-A---DTVDDFWRVLV-NGENHV-IEIP-P--E-RW-NVDE--YYS----ADYDEPGKT-YVRRAGFL-----Q-N--FD-EFDPKMFGISEP-EAAKMDPQQRYILECVHMALEDGGIMR--------KDIHG--SRTGVYI---------------------------------------G-VMNDDY--KSSA-TE-----------D----P--A-VASNYTLTGTAPSIVAARISYVYNLLGPS------MSIDTACSSSLVAIHLAQQALRAGDCNMCICGGVNSILYP-DIFIPLSKARMVSPTGQCQAFADTAD--------------------------------------------------------------------GYIRGEGGGVIVLKRLK-D--------------A--RADGNKIWA-TIA-TGCN--QDGRTMT-------P---ITAPSVQMQTELLQEVYEM-N-NVNP-DLIQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEANSLG-EFFF-Q------Y--MT----E---------------------------------------------------G--K-----N-PLKIGSVKTN-IGHLESAAGVAGIVKVLLMMKHGQLVRSLH-FV-N------PNPKID-FPKYNMAVSI--DVS-DWPT--L-P--D-GTRMSCVNSFG-FGGTNSHAIIKQFP----------------------------------------------------------------------------------------------------- 242 ------------------------VVISGVSCRLP-E-S--D-NVEEFRQHLM-NRDDMV-TD---DDR--RW-PQGL--------------Y--G-LPTRNGKLK--------DISK-FDASFFGVHPK-QANSMDPQLRLMLEVTYEAIVDAGVNP--------DKIKGS--KTGVFI---------------------------------------G-CSASEA--HDAW-SY---D------------P--E-KTVGYSMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------FAIDTACSSSLLAMDQALHSIRQGHCDSAIVGGCNLCLKPTTSLQFLKLGMLSKD-GTCKSFDASGDGYCRSEGVVAIFLQRES-D--------------A--IR----IYC-TVVHSKTN--SDGCKEQ-------G---ITFPSGAVQKQLLQEIYTE-A-CIDP-TTVEYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQELNTIT-DVFC-K--G---R----------------------------------------------------------------E----T-PLLIGSVKSN-MGHPEPASGLAAVTKLIVGMEDKLIPANLH-Y---N--T--PNPDIPGLVDGRLEVIT--QAT-EFNG-----------GLMAVNSFG-FGGSNVHVVLKP--NQE--I--Q-------------TKS--ID-L-------------------------S------KRLCLYSSRTQEGLEKVL-------------------- 243 VGNAATNGASDNTETFQSDAILDDVVISGVSCRLP-E-S--D-NIEEFRQHLI-NKDDMV-TD---DER--RW-PQGL--------------Y--G-LPPRNGKLK--------DISK-FDAAFFGVHPK-QANTMDPQLRLLLEVTYEAIVDAGVNP--------DRVRGS--RTGVFI---------------------------------------G-CSASES--HDAW-SY---D------------P--E-KTVGYSMTGCTRSMFANRLSFFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLLAMDQALHNIRSGLCDAAIVGGSNLCLKPTTSLQFQKLGMLSKE-GTCKSFDESGDGYCRSEGIVAIYLQKHK-D--------------A--KR----IYS-TIVHSKTN--SDGNKEQ-------G---ITFPSGSIQKQLLQEVYSE-A-CIDP-ATVEYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQELNTIS-DVFC-K--D---R----------------------------------------------------------------L----S-PLLIGSVKSN-MGHPEPASGLAAVTKLIIGMEDKMMPAN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 244 -------------------------AIIGLSCRLPK--S---DNLEEFWDNLI-KGRDLI-G-------ETRW-PKG---LYD--------------TPPRAGLIK------G--ID-KFDAQFFQFTD-TEAHNMNPLLRHLFEVSYECIADSGIPL--------SVLHSN--TTGTYT---------------------------------------A-CFISDN--DPL-ET---------------------SKC-ANSKYCTTAPMITGHLMNQFRFTGPS------ATVDTACSSSISALEMAVTDLMTGRCQFAMVTACNLLLNP-SYLQQMCFLGMLCSEGQSRVFDAGAK--------------------------------------------------------------------GYVRAEGIVSILLTRQA-N---------------ICQR----IYAS-VIDVKTN--CNGYNPD-------G---ITFPSKDGQSTLMKEVYK-R-SEIKT-DDIAFMEMHS-----------------------------------------------------------------------T-GTPV------G------DPIEVRSVT-DAIC-ST--R------------------------------------------------------------------E-----K-PLLIGSVKAN-MGHSEATAGLASLVKVILAAQHGVIPPQCN-YS-----S--PNPNIEAIREGKVIVVT--DPT-ELQD----G-------YIGLNSFG-FGGSNGHVILKPFK----RK----------------------------------------------------------------------------------------------- 245 ------------------------VCISGMSGRMP-E-S--A-NIEEFKEHLM-KNEDMA-TA---DDR--RW-PV-------------GI-H--G-IPPRNGKLN--------DLDK-FDAGFFGVHAK-QADNLDPQLKMLLECSYEAIIDAGETM--------ESVRGS--RTGVFV---------------------------------------G-ASVSEC--NEVW-SS---N------------A--D-TMVGYSLPGCSRNMFSNRISFFFDFKGP------S--------------------------------------------------------------------YTVDTACSSSAMCLNQALQNIRMGIIDAALVGGANLVLKAMQSLQFQRMGMLAPD-GACKTFDASGNGYCRSESVMAIYLQKAK-D--------------C--KR----VYA-TLVHSKTN--SDGYKEQ-------G---ITFPAGTMQKRLIREVYHE-C-GISP-NDISYIEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNSLS-EVFC-E--G---R----------------------------------------------------------------K----D-PLLIGSIKSN-MGHSESCSALNAIGKVLIAMENEMIPANLH-F---K--S--PNPEIAALVDGRFKVVA--ENT-RWKG-----------GLAALNSFG-YGGSNVHYVLRSN--N--KE--L-K------E----AHP--AS-Q-------------------------K------VRLFTYCGHTEAGVREVL-------------------- 246 ------------------------IAIIGIGCKLP-G-A---DNIEEFWRVLK-NGENHV-LEVP-K--D-RW-NLEA--FYD----PDPNAPGKT-YVRRAGFI-----K-N--QE-EWDNKVYGVNDF-EASQMDPQQRFVMDCCYRAMENAGITR--------KELDG--SKTGVFI---------------------------------------G-VMNSDY--KALQ-ST-----------S----S--E-HMNNYTLTGTSTSIIASRVSFNYNLVGPS------LTLDTACSSSLLAIHLAANSLILGDCELAFAGGVNSLMSP-GIFVQLSKARMASPTGYCQAFSNKAD--------------------------------------------------------------------GYARGEGAGIILLKRLK-D--------------A--VRDNDPIWA-TIM-TGCN--QDGHTVT-------P---MTAPSGSQQHELLKSMYTK-Y-NIDP-DKLEYIEAHG-----------------------------------------------------------------------T-GTQA------G------DPVEANCLG-GFLA-----------------------------------------------------------------EH-TK--N-----A-PRYIGSVKTN-IGHLESAAGVAGVIKVLLMQKYSTIVPTLH-FD-----Q--PNEKID-FDKLKLVVAT--EVD-QWPS--YND--D-GSKLSCVNSFS-FGGTNCHAIIKSYV----R---P-K----T-R---N-EV--K---FGM--DKS-------------------------HIICFSGMD-------E-------------------- 247 ------------------------IAIIGIGCKLP-G-A---DDIDQFWRVLQ-NGENHV-LEVP-P--D-RW-NLDA--FYD----PDPNAPGKT-YVKRAGFV-----K-N--HE-FWDNKVYGVNDF-EAGQMDPQQRFVMDCCFKAMENAGVTR--------KSLDG--SNTGVYI---------------------------------------G-VMNSDY--KSLQ-ST-----------T----S--E-HMNNYTLTGTSTSIVAARISFNFNLLGPA------LSLDTACSSSLLAIHLAAQALREGDCDLAFAGGVNSLMSP-GIFVQLSKARMASPTGYCQAFSNKAD--------------------------------------------------------------------GYARGEGAGIILMKRLK-D--------------A--ERDNDPIWA-TIM-TGSN--QDGHTVT-------P---MTAPSGSQQLNLLKKVYTR-Y-NIDP-DQLEYIEAHG-----------------------------------------------------------------------T-GTQA------G------DPVEANCLG-AFLE-----------------------------------------------------------------EH-TM--N-----A-PRYIGSVKTN-IGHLESAAGVAGVIKVLLMQKHSMIVPTLH-FD-----E--PNEKID-FDKLKLVVAT--KVD-KWPT--FTN--D-GTKLSCVNSFS-FGGTNCHAIIKTYA----K------------------------------------------------------------------------------------------------ 248 ------------------------IAIIGVGCKLP-G-A---DDTDQFWRVLQ-NGENHV-LEVP-A--D-RW-NLEA--FYD----ADPATPGKT-YVRRAGFI-----K-N--QT-AWDNKVYGINDF-EASQMDPQQRFVLDCCFKALENAGVTK--------KSIDG--SNTGVYI---------------------------------------G-VMNNDY--KSLQ-AG-----------S----S--S-NMNNYTLTGTSTSIVAARISYNFNLLGPS------LSLDTACSSSLLAIHLATQALREGDCDMALAGGVNSLMSP-EIFIQLSKARMASPTGYCQAFSDKAD--------------------------------------------------------------------GYARGEGAGILLLKRLK-D--------------A--ERDNDPIWA-TIM-TGCN--QDGHTVS-------P---MTAPSGSQQLALLEKVYKR-Y-NIDP-NELEYLEAHG-----------------------------------------------------------------------T-GTQA------G------DPVEANCLG-TFLK-----------------------------------------------------------------DY-PK--N-----S-PKIIGSVKTN-IGHLESAAGVAGVIKVLLMQKHSTIVPTLH-FD-----K--PNEKID-FEKLKLNVAT--KLD-KWPS--YTQ--D-GCKLSCVNSFS-FGGTNCHAVVKSYN----K---R-K----R-A---E-TI--E---SIQ--SRP-------------------------RIICFSGTDDTS----L-------------------- 249 ------------------------VAISGISGRMP-E-S--N-NMEEFADHLM-NKEDMV-TA---DDR--RW-EM-------------GL-H--G-MPTRNGKLK--------ELRH-FDAGFFGVHPK-QADCMDPQLRMLLEACYEAIIDAGQTL--------ESVRGS--KTGVFI---------------------------------------G-VSTSEA--IEAW-SS---D------------A--E-TLVGYSMPGCCRAMFANRISFFFDFKGP------S--------------------------------------------------------------------YALDTACSSSMMCLDQALLNIRMGLIDSAIVGGSNLCLKPNTSLQFVRMGMVAPD-GACKTFDASGDGYCRSEAVMAMFLQKSP-D--------------C--KR----IYA-TVVHTKTN--SDGHKEQ-------G---ITFPSGILQKQLINEVYHE-I-GINP-LDVSYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINTIT-DVFC-K--G---R----------------------------------------------------------------K----D-PMLIGSTKSN-MGHPEAASGLTSIAKIIIAMENKVIPPNLH-Y---K--S--PNLEIPGLSDGSLQVIT--ECT-PWDG-----------GLVAMNSFG-FGGSNVHAIYRSH--N--KE--L-Q------Q----PHV--AS-E-------------------------K------PRLFTYSARTEEGVLAVL-------------------- 250 ------------------------VVVSGISCRLP-E-S--D-NMEEFRHNLM-DNVDMV-TE---DDR--RW-QPGM--------------Y--G-LPRRNGKLK--------DISK-FDAAFFGVHPK-QANCMDPQLRMLLEVTYEAIVDAGVDP--------SLVRGS--KTGVFI---------------------------------------G-ASASES--HEAW-SG---D------------V--D-TVVGYSMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------YTIDTACSSSLLALDQALHSIKQGHCDSAIVGGSNLCLKPTTALQFQNLGMLSPD-GTCKSFDEQGNGYCRSEGIVSIFLQKHT-D--------------A--KR----VYA-TVIHSKNN--SDGSKEQ-------G---ITFPSGSIQRQLLLEVYNE-C-CVDP-STVSYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIA-DVFC-K--G---R----------------------------------------------------------------Q----Q-PLLIGSVKSN-MGHSEPASGLAAVAKVLIAMENVTLPANLH-Y---N--T--PNPDIPGLVDGRLQVVT--TNT-EWNG-----------GIVGVNSFG-FGGSNVHAVLKSNSNSQ--K--S-------------SSK--NN-T-------------------------S------KRLAVCTARTEEGVQKIL-------------------- 251 ------------------------IAIIGVGCRFP-G-A---DNIDEFWKVLL-HGENHV-VDIP-N--D-RW-NVDA--IYD----ADPDAPGKT-YVRKAGLI-----V-G--HD-TWDNNFFGISDL-EAEQIDPQQRLVLDCVHMALENAGVRK--------TDLNG--SSTGVYI---------------------------------------G-TMNDDF--THGM-NE-----------D----P--G-VLTNYSVTGSARSIISARVSYLYNLLGPA------MTIDTACSSALVAIHTGIQAIKMGDCNMALCGGANGILYP-ELFIALSKARMLSPTGQCQPFSAKAD--------------------------------------------------------------------GYARGEGCGIILLKKLT-D--------------A--QKDGDYIWG-TII-TGCN--QDGHTAS-------P---MTAPSLSQQKHLLEKVYGE-N-NVDP-CSVQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEVDSLG-TFFM-EH--RA-K--QT--------------------------------------------------------D--L-----K-KLLIGSVKSN-IGHTESAAGVAGIIKILLMMKNETIVPSLH-SE-K------LNPKIH-FDTYGLHVVQ--NCT-PWEQ--N-A--S-KRRVACVNCFG-FGGTNSHAIVEQDL----K--TQ-Q---PH-T---S-L--------EN---LDTK-E-----------V-R------PYIIAISAADNWSLEQI--------------------I 252 --------------------------IAGMSGKLP-E-S--E-NLQEFWANLI-GGVDMV-TD---DDR--RW-KAG-------------L-Y--G-LPKRSGKLK--------DLSK-FDASFFGVHPK-QAHTMDPQLRLLLEVSYEAIVDGGINP--------ASLRGT--NTGVWV---------------------------------------G-VSGSEA--SEAL-SR---D------------P--E-TLLGYSMVGCQRAMMANRLSFFFDFKGP------S--------------------------------------------------------------------IALDTACSSSLLALQNAYQAIRSGECPAALVGGINLLLKPNTSVQFMKLGMLSPD-GTCRSFDDSGSGYCRSEAVVAVLLTKKS-L--------------A--RR----VYA-TILNAGTN--TDGSKEQ-------G---VTFPSGEVQEQLICSLYQP-A-GLAP-ESLEYIEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNGIT-RSLC-A--F---R----------------------------------------------------------------Q----A-PLLIGSTKSN-MGHPEPASGLAALTKVLLSLEHGVWAPNLH-F---H--N--PNPEIPALLDGRLQVVD--RPL-PVRG-----------GNVGINSFG-FGGSNVHVILQPN--T--RQ--A-P------A---P-TA--HA-A-------------------------L------PHLLHASGRTLEAVQDLL-------------------- 253 ------------------------VAISGMSGRLP-E-S--A-NIEEFQEHLM-NNDDMV-TE---DNR--RW-DV-------------GL-H--G-LPPRNGKLK--------ELAH-FDAGFFGVHPK-QADNMDPQLRMLLECSYEAIIDAGQTL--------ESVKGS--RTGVFV---------------------------------------G-TSQSES--SEVW-SS---N------------P--E-TVVGYSLTGCSRNMFANRLSFFFDFKGP------S--------------------------------------------------------------------YSVDTACSSSAMCFDQALQNIRMGVIDAAIVGGCSLVLKATQSLQFLRMGMLAPD-GACKTFDASGNGYCRSESIMAIYLQKVP-D--------------C--KR----IYA-TIVHSKTN--SDGHKEQ-------G---ITFPSGEQQQNLIKEIYHE-A-GISP-QNISYIECHG-----------------------------------------------------------------------T-GTKI------------GDPQEVNSLA-DIFC-K--G---R----------------------------------------------------------------K----E-PLLIGSVKSN-MGHSE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 254 ------------------------------------G-A---DNIDEFWRVLV-NSENHI-IDVP-T--E-RW-NNDA--FYS----ENKDEAGKT-YVKKAGFI-----K-G--HD-EWDNKFFGVSDN-EATNVDPQQRFVLECTQMALEDAGITK--------SQIQK--TQTGVYL---------------------------------------G-VMNEDY--RGLS-LF-----------D----H--Q-DDTNYSATGMSSTIISARVSYFYDLRGPC------MVVDTACSSSMVAIHLGSQAVRTGDCEMAICGGVNCMLSP-DIFMMLCKARMLSPIGQCQSFCETAD--------------------------------------------------------------------GYGRGEGCGIVIVKSYE-K--------------A--VRDGNKIWG-IIK-TASN--QDGHAAQ-------P---ITAPSGDQQKELLKKIYTY-Y-GIDP-TTLQYIEAHG-----------------------------------------------------------------------T-GTAV------G------DPIEVNALG-AFIE-EY--R---------SNVSMGGKGSVYTT----NVNKYMENTTGTETVSD--------I---YPG-HNFR--K-----H-TILIGSVKSN-IGHLESAAGVAGLIKVLLMMKYGKYVPSLH-VN-KDKSN--INKKIG-LDLYGLDVSV--AVT-EWLP--N-E--D-GNRICCVNSFG-FGGSNTHAIVIQ------------------------------------------------------------------------------------------------------- 255 ------------------------VAIVGVGCKFP-G-A---DNVAEYWRVLK-NGENHV-KQIP-R--D-RW-NNEA--FYD----PDRNAPGKT-YVRTAGFV-----N-S--IN-EWDHRFYGISDK-EAELVDPQQRIVMDCVHMALEDGGITR--------NDIKG--TQTGVYI---------------------------------------G-SMNDDY--KGQV-ID-----------D----T--I-LSSTYSVTGTHNSIISARVSYTYNLFGPA------MTIDTACSSSLVAIDVASQAIRTGKCSMAICGGVNILMDP-HMFVVLAKAGMLSSTGQCKTFTKDAD--------------------------------------------------------------------GYARGEGCGIILLKSLN-D--------------A--VKDGNKIWG-TIK-TGTN--QDGQTAT-------P---ITAPSKSQQERLIEETYAR-Y-NVDT-AKIKVIEAHG-----------------------------------------------------------------------T-GTVI------G------DPREVEALG-SHFG-RK--A-KV---------------------------------------------------------------P-----C-NVFIGSVKTN-IGHLEAAAGVAGIIKVLLMMTHGVIVPSLW-YT-KE--N--ENPREV-EALG--------------SH--F-G--R-KAKVP-------------------------------------------------------------------------------------------------------------------------C 256 ------------------------IAVIGVGCRFP-G-A---DNLKEFWRVLV-NGENHV-VDIP-P--E-RW-NNDA--FYS----EDRSEKGKL-YTKKAALI-----N-H--FD-EFDNKLFGISDN-EAQQIDPQQKFVLECVHMAMEDGGITR--------KQLNG--SLTGVYI---------------------------------------G-AMASDY--NGMF-DF-----------D----L--D-DVTTYTATGTNSSIISARVSYVYNLQGPS------MVIDTACSSSVTGVHLGCQAIRNGDCEMAICGGVNCLLSP-NTFVVICQAGMLSPSCQCQAFCDTAD--------------------------------------------------------------------GYVRGEGCGIVILKSYK-K--------------A--LQDGNKIWA-TLK-TGIN--QDGHVAQ-------P---ITAPSGDQQEKLLERVYHQ-Y-NIDP-ASLQYIECHG-----------------------------------------------------------------------T-GTTI------G------DAIEVNSLG-RFIK-SH--R---------QSPETQVKQERQYL----GTSDQGHGENQNVLADEEIQDNAKTLAKENSK-CKWK--H-----E-PIYIGSVKTN-IGHLEAAAGIAGLIKVLLMMENGTLVRSLH-VK-QDKSN--LKRAIR-FEEYGLDVPL--DVV-SWHQ--N-E--N-GERISCVNSFG-FGGSNSHAIVIQKS----QG--G-K----L-----S-EE--SS-E-RK---IK-------------------------LIAL-SAPDKNSL-Q-K-------------------- 257 ------------------------IVIVGVGCKFP-G-A---NNLEEYWRVLS-NGENHV-KEIP-K--D-RW-NIDA--FYD----ADPDAPGKT-YVRRAGFV-----D-G--ID-EFDNRFYGINDE-EAKIVDPLQRLVLDCTQMALEDGGITR--------KDIDK--SDTAVYI---------------------------------------G-CMTDDY--KGHV-MD-----------D----N--T-IASAYSVTGTHNSIISARVAYVYNLLGAA------LTIDTACSSSLVAIDVASQALLGGQCKTAICGGVNVLLDP-QLFIALAKARMLSPDGQCKTFTNENK--------------------------------------------------------------------GYARGEGCGIVIVKKFK-D--------------A--LADGNKIWG-VIK-TGTN--QDGSIVK-------P---ISAPAEEQQRNLIEHLYKK-Y-DVDR-SKISVIEAHG-----------------------------------------------------------------------T-GTPI------G------DPTEVGALG-AYFG-KR--A-GA---------------------------------------------------------------P-----S-NELIGSVKTN-IGHTEAAAGVAGLIKVLLMMKKQTVVPSLW-YS-PD--N--ENPKLK-LSNLGFKVPT--KCL-PWKT--T-S-SQ-NVRIACVNSFG-FGGTNSHAIVEEYT----RH--Q------I-K---S--------------------AS-AIEE--R------------------------------------------------L 258 ------------------------IVIIGVGCKYP-G-A---DNLDEFWKVLI-NGENHV-NEIP-K--D-RW-NLEA--FYS----ADPDQKGKT-YVRRAGLL-----H-N--HD-VWDNKLFGISDT-EAEKIDPQQRYVLECVHMALEDGGITR--------QEIDG--TDTGVYV---------------------------------------G-FMNDDY--RNAA-GD-----------G----L--D-AFNNYTLTGTSPSIIAARVSFTYNLLGPS------MALDTACSSALVAVDVGVQALKTGRCKTVIAGGVNSILYP-DVFVGLSRARMVSPTGQSQAFSDKAD--------------------------------------------------------------------GYARGEGCGMVILTTMK-Q--------------A--LEKGRKIWA-VIA-TGCN--QDGHTTS-------P---ITSPSETQQRILLETVYAE-N-NINP-GLVSVIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEANSLG-GFFG-RK--K--T------------------------------------------------------------E--D-----T-PVYIGSVKTN-IGHTESAAGTAGLIKVLLMMKHEKIVPSLL-VE-K------INPKID-FGICNFEVPR--KPL-TWRK--P-S--Y-GPRIACVNSFG-FGGTNSHVIVKE------------------------------------------------------------------------------------------------------- 259 -------------------------VIAGLSCRLPK--S---DNIEEFWDNLI-NGKDMI-G-------ETRW-PKG---IFD--------------TPPRVGLIN------D--ID-KFDAGFFKFTD-TEAHNMNPLLRHLLEVSYECIADSGIPL--------SVLHSN--ITGTYT---------------------------------------A-CFIPDN--DFI-ET---------------------SRC-ADSKYCTTVSMITGHLMNQFRFTGPS------ATVDTACSSSVSAMEMAIADLMAGRCQFAMVTGCNLILNP-GFLEQMCYLGMLSLEGQSRVFDADAK--------------------------------------------------------------------GYVRAEGIVSILLTRQA-N---------------ICPR----IYAS-VIDVKTN--CNGYNPD-------G---ITFPSKDCQCALMKEVYR-Q-SDIKP-DDIAYMEMHS-----------------------------------------------------------------------T-GTPV------G------DPIEAESVT-EAIC-SN--R------------------------------------------------------------------K-----N-PLLVGSVKAN-MGHSEATAGLASLVKCILAARHGIIPPQRN-FN-----T--PNPKIDAIKDGKMVVVK--EPT-ELKD----G-------YIGLNSFG-FGGANGHVVLKPFR----RK----------------------------------------------------------------------------------------------- 260 ------------------------VVVSGVGCRLP-E-S--D-NISQFRDHLM-NGDDMV-TE---NNR--RW-EPGA--------------Y--G-LPRRSGKLK--------DISK-FDALFFGVSPR-QANNMDPQLRLLLEVTYEAIIDAGVSP--------YKMRGS--RTGVFV---------------------------------------G-CSSSES--HEAW-TT---D------------V--E-NVEGYTMIGCQRAMFANRLSFYFNFRGP------S--------------------------------------------------------------------YTMDTACSSSLLALDQALLSIRLGYCNSAIVAGCSLCLKPQTAQQFNKLSMLSEY-GACRSFDASGAGYCRSEGVIALFIQHIS-A--------------A--NR----MYM-TVVHTKNN--ADGAKEQ-------G---ITFPSGAVQESLIREVYSD-A-GIKP-SAVSYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNGIA-AVFC-E--R---R----------------------------------------------------------------A----T-PLLIGSTKSN-MGHPEPASGLAAMCKIIVAMESGIIPANLH-Y---N--T--PNPDIPALVDGRLKVVS--ENT-PWQG-----------GFVGINSFG-FGGSNVHAILESN--A--IR--T------R-S----WHE--GA-G-------------------------D------VRLCVSSARTEEGTAALL-------------------- 261 ------------------------VVIVGVGCRLP-G-A---DNLDQFWRVLF-NGENHV-IDIP-K--D-RW-NIDA--FYD----ADPDAPGKT-YVRKVGIV-----K-D--HD-KFDNRLFDVNDI-EAAKMDPQQRFVLESTFMALENAGIPR--------SSVSG--SNTGVFM---------------------------------------G-LMNCDY--TDIL-AA-----------D----M--E-QADNYTLTGGAASIAAARVSYVFNLLGPA------LSIDTACSSALIAIHLASQALKLGDCDMAICGGVNCIMLP-SVMIPLSKARMVSPTGASRAFSAEAD--------------------------------------------------------------------GYARGEGCGIVILKKKS-D--------------A--IANGDSIWA-TIK-TASN--QDGRMAS-------P---ITAPSGDQQQLLLCQTYPR-Y-GVDP-KEIQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEANSLG-SFF------------------------------------------------------------------G--QD--G-----A-LRYIGSVKTN-IGHLESAAGIAGLVKVLLMMKKATIAPSLH-FV-----N--PNPKIE-FQKYNFKVPT--ECY-PWDP--LP---D-GRRLACVNSFG-FGGSNGHAIITQYP----EE--K-Q---------------------------------------------------------------------P-------------------- 262 ------------------------VVVSGISCRLP-E-S--D-SMAEFREHLV-KGEDMV-TD---DDR--RW-TPGL--------------H--G-LPTRSGKLK--------DISK-FDCSFFGVNPK-QANAMDPQLRLLLEVAYEAIVDAGVNP--------QSVRGS--RTGVFI---------------------------------------G-ASGSEA--HEAW-ST---D------------P--E-KIVGYCMTGCQRAMFANRLSFYFDFKGP------S--------------------------------------------------------------------YTMDTACSSSLLAMDQALLNIRLGLCDSAIVGGASLCLKPQTALQFMKLGMLSPD-GACKSFDASGNGYCRSEGIVAIFLQKSP-E--------------A--KR----VYC-TLVHSKNN--ADGNKEQ-------G---ILFPSGAQQQKLVREVYTE-S-GVNP-ADVQYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNSIA-DVFC-P--G---R----------------------------------------------------------------D----A-PLLIGSTKSN-MGHPEPASGLAALAKLVIAMEDGVIPQNLH-F---Q--S--PNPDIPALADNRLKVVS--EPT-QWAG-----------GLAAINSFG-FGGTNVHAVLKSN----PK---R-N----T-A----AIK--ES-D-------------------------S------KRLFLCSSRTQEGLDKIL-------------------- 263 ------------------------VVVSGVGCRLP-E-S--D-NIAEFRDHLM-NGDDMV-TE---NDR--RW-EPGA--------------F--G-LPRRSGKLK--------DITK-FDGLFFGISPR-QANNMDPQLRLLLEVTYEAIIDAGVSP--------YKIRGS--RTGVFV---------------------------------------G-CSSSES--HEAW-SS---D------------A--E-NVEGYTMIGCQRAMFANRLSFYFNFRGP------S--------------------------------------------------------------------YTMDTACSSSLLALDQALLSIRLGYCDAAIVAGCSLCLKPQTAQQFNKLSMLSDY-GACRSFDASGAGYCRSEGVIAIFIQQVS-V--------------A--NR----LYM-TVVHTKNN--SDGAKEQ-------G---ITFPSGEIQESLIREVYSD-A-GIKP-SDVAYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELGGIT-NVFC-E--N---R----------------------------------------------------------------T----G-PLLIGSTKSN-MGHPEPASGLAAMCKIIVAMETGVIPANLH-Y---N--T--PNPDIPALTDGRLKVVS--ENT-PWEG-----------GVVGLNNFG-FGGSNVHAILESN--T--LK--S------R-T----WHD--GA-G-------------------------D------VRLCLASARAEDGVQGML-------------------- 264 --------------------------IGGVACRLPK--S---NNIQEFWENLI-NGVDMI-D-------FTRW-PPG---LHG--------------VPPRLGLIP------D--IE-KFDSLFFGFQD-HEVNGFSPMYRHLLEVTCECIIDSGLDM--------KTIHNS--RVGYYL---------------------------------------S-CFLTDT--DCL-ET---------------------SRPPLTCSLMSIGPNLAGSVTQWFSLNGPI------VMVDTACSSSISALHMAVTDLVIGRCEYAIVASANLIFNP-NMLQQMGQLNMLCPEGRSRVMDAEAG--------------------------------------------------------------------GYVRAEGVVTMLLSRKP-D---------------DCKR----IYAS-VIDVGVN--CDGYKNE-------G---ITYPSKQMQVELVRQVFD-R-SGIHS-NQLAYVEAHS-----------------------------------------------------------------------T-GTQA------G------DFVEVSGLM-ESLG-EG--R------------------------------------------------------------------D-----K-RLLIGSVKSN-MGHSEATAGLAGIAKCLLIAKHKLIPPNIN-FK-----T--PNPKIESILSGKLKLVT--EPT-PLED----G-------YIAVNSFG-FGGANGHVILQPFR----AP--E-S------T---R-ET--E----AP----------------------K------HGLVLLGARSEAEVTE-V-------------------- 265 ----------------------------------------------------------MV-SE---DDR--RW-EPEY--------------C--G-LPPRSGKLK--------DINK-FDASAFGVHPK-QADVMDPQLRMLLEVTHEAIVDAGVSP--------QSIRGS--KTGVFV---------------------------------------G-VGLSEA--LEAW-SS---D------------P--N-SPSGYVTTGCTRNMFANRISFSFDFKGP------S--------------------------------------------------------------------FGIAVGCASSLRALDQALLSIRIGDCDTAIVGGSNLTLKPMTAQLYMRQDMVD-----------ESDGCCQSEGIVVIFLQKIS-V--------------A--KR----IYA-TVLHAKNK--AFGCYVE-------N---MACPSSCLQTELLKEVYQE-A-ELNP-LDVTYVETNG-----------------------------------------------------------------------I-GTTQ------------ANREEIQTLV-DVFC-K--Q---R----------------------------------------------------------------K----N-PLLIGSAASV-MGHSAAVSGLASVAKVIVAMEEGMMPSCFP-S---Q--S--KGMGILKIADG-------------------------------------------------------------------------------------------------------------------------------------------------------- 266 ------------------------VAIVGIGCRFP-G-A---TNKDEFWKLLL-NGENHI-TEVR-K--H-RT-GFES--YFI----SDPIDPNKK-HPYKAGLI-----D-R--FS-QWDNKVFGIPDE-EAKWVDPQQRFVLDCVHMALEDAGITR--------HELSG--TNTGVYI---------------------------------------G-AMNDDF--KSAI-LE-----------N----A-DN-EDSSYMVTGLSLSIISARVSYIYNLFGPS------MTIDTACSSSLVAIHQGSLSLRAGECKMAICGGVNLLLDP-RVFVSLANARMMSPSGQCHSFSSKAD--------------------------------------------------------------------GYTRGEGCGVVILKHTQ-D--------------A--IRDGNIIWG-LIG-TGIN--QDGHMAT-------P---MTAPSGEQQLALLRRVYRE-Y-KVCA-SSVQVIEAHG-----------------------------------------------------------------------T-GTPV------G------DPVEANSLG-TFFK-EN--SS-S--S------------------------------------------------------------I--------KYIGSVKSN-IGHLESASGVAGLIKIILMMRNEIIVPSLH-VK-EE--G--LNNKNS-LVKNGLIVPT--EPV-AWPS--L-D--G-RPKLACVNNFG-FGGTNAHAIVSEYI----GQ--S-Q------R---D-ES---S-L---------------VIN-----I-E------PVIIVLSSTSLKG----L-------------------- 267 ------------------------VAVVGLGCRFP-G-A---NDKDGFWRLLE-NGENHI-IDIK-D--K-RP-GFDS--SYV----TDPNDPGLR-RAYRAGLV-----E-R--FS-HWDNKVFGIKDG-EAKWIDPQQRFVLDCVHMALEDAGITR--------KELDG--SNTGVYI---------------------------------------G-AMNDDF--KNVI-LE-----------D----Q-DS-EESSYMVTGLALSMISNRVSYVYNLHGPS------MNIDTACSSSLVAIHQGSLALKAGECDIAICGGVNLILDP-RVFVSLFNSRMLSPTGQCHAFASKAD--------------------------------------------------------------------GYTRGEGCGIVILKRVK-D--------------A--LEHENKIWG-LVG-TAIN--QDGHEAT-------P---ITSPSGKQQLALLEKIYKE-Y-SIHS-SSVQVIEAHG-----------------------------------------------------------------------T-GTPV------G------DPVEANALG-TFFY-KT--DS-S--T------------------------------------------------------------T--------TYLGSVKSN-IGHLESASGVAGLIKVLLMMKNGKVVPSLH-VK-EE--G--INMKTN-IEQNGLTIPA--ETV-NWLY--H-D--A-KPRTACVNSFG-YGGTNAHVIVREYK----MK--K-H------V---H-KV---S-S---------------ATK-----T-G------PVIVVMSATSNDALH--A-------------------- 268 ------------------------MAVIGIGCRFP-G-A---DDIDEFWRLLR-NGENHV-LEIS-R--D-RF-NVSA--YYD----PDKDKIGKT-YNKTAGLV-----R-D--YD-MIDSQLYGIDES-VAARMDPQQAFVLDCTHMALEDAGIPP--------SSLQG--SKTGVYI---------------------------------------G-CMNTDY--KADV-VK-----------D----P--T-DISKHSQTGSTGSAIASRLAFTYNLQGPA------MIVDTACSAALVALNTAARAICAGDVDMAICGGVNAIMDP-TAYVALSRAKMAGATGQCQAFSDNAD--------------------------------------------------------------------GYARGEGCGIIIIKKYS-KAVL----------------DDNKIWA-RIL-TGCN--QDGRTVT-------P---MTAPSGDQQVALLKHVYGH-F-GVDP-MSVQYLEAHG-----------------------------------------------------------------------T-GTPI------G------DPTEVNALG-YFFS-TQ--ES-K--EER-GEK----------------------------------------------------PVV-----D-KIKIGSVKSN-IGHLESAAGAASVIKMMLMMKHGEFVPSLM-CE-----P--ANKKIH-FDRFRIEVSK--EVC-EWKT--N-S--S-GQRLGGINCFG-FGGTNSHAVVIQEN----ND--Q------V-S---C-QG--NR-E--G---T--K-YI-FA-------Q-S------AVNEASLKA----------------------------- 269 ------------------------VAIIGVGCRFP-G-A---DNISEFWRLLR-NGENHI-TDIP-L--E-RF-NAAA--FCD----PDCTEAERT-SMTKAGLV------MT--YD-LWDNQLFGINDI-EAKRIESQQRFAVDCTFMAFEEAGITL--------KMVNG--SNTGVFI---------------------------------------G-SMSTDT--KDSI-SH-----------D----A--E-DLTNYSTTSSATSIIASRVAYTFNLLGTA------MTLDSGYSSDMAAIHTASQALLAGDIDMAVCGGTNAILDP-TPFIAMYKSAQYGQG--------TTS--------------------------------------------------------------------ITTRGEGCGIILTKTLS-K--------------A--LADGNKIWG-TLE-TKCS--HTGSTPI-------S---FSSPSRCHMLPLWTSAYTK-A-NVDP-QLVQYVETDG------------------------------------------------------------------------LLTKS----QDT------DQSELAAMH-EFFC-KE--EN-R--QEHRKEI----------------------------------------N----ND-SNGK--D-----F-PRKIGAVKHN-IGHLEGAAGMASLIKILLMMKYEEFVPTLV-GP-----E--LVS--F-AERFSFYVPT--AVQ-PWAE--N-S--A-GQRTASFNCFS-FSGTNFHVIVQQN------------------------------------------------------------------------------------------------------ 270 ------------------------VAIIGIGCRFP-G-A---DNIDEFWHLLR-SGENHV-SEIP-R--D-RF-NISA--FYD----EDKDKIGKT-YNKTAGLV-----R-D--YD-MVDSPLYGISES-EASRMDPQQSFVLDCTHMALEDAGIPP--------SSLRD--SKTGVYI---------------------------------------G-CMNADY--KSDV-VM-----------D----V--T-DISQYSLTGNTGSAIASRVAYTFSLQGPA------MMIDTACSAALVALHTAARAIGAGDADMAICGGVNVIMHP-HAYVALSRAKMAGTTGQCQAFSDNAD--------------------------------------------------------------------GYARGEGCGIIIIKKYS-KAVV----------------DGNKIWA-RML-MGCN--QDGRTVT-------P---MTAPSGYQQAVLLKNIYKQ-C-GVDP-MSIQYIEAHG-----------------------------------------------------------------------T-GTPI------G------DPTEVNALG-YFFS-SP--EG-D--EEK-DEK----------------------------------------------------PVF-----D-KIKIGSVKSN-IGHLESGAGVASVIKMVLMMKHGEFVPSLM-CE-----P--ANKKIL-FDQFRIEISK--EVC-EWRA--N-S--T-GQRLGCINCFG-FGGTNSHAIVIQDN----VD--P------F-P---C-HG--NI-H--G---T--E-YV-FV-------Q-S------AENKASLKA----------------------------- 271 ------------------------VVASGLSGRLP-E-S--S-NISEFRENLV-RGRDMV-TE---DGR--RW-TPGL--------------Y--D-LPKRNGKLK--------ELDK-FDAAFFGVPPK-QANAMEPQLRMLLEVSYEALVDAGIDP--------FSVRGS--RTGVFV---------------------------------------G-ASESEA--HQAW-SA---D------------P--E-TTIGYHMTGCARSMFANRLSFFFDFKGP------S--------------------------------------------------------------------IVIDTACSSSLLAMDQALLSIRMGLCDAALVAGTSLCLKPTSSLQFKRLNMVSTE-GCCKSFDSSGNGYVRSEAVVVVFLQKAK-N--------------A--KR----IYA-TLVHSKNN--ADGNKEQ-------G---ITFPSGEIQKRLISEVYIE-S-GIDP-LSVVYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQELNSIT-DVFC-K--G---R----------------------------------------------------------------D----G-PLLIGSTKSN-MGHPEPASGLAALAKVLIAMEDGMIPANLH-F---N--D--PNPDIPGLLDGRLRVVT--ERL-RWNG-----------GYVGINSFG-FGGSNVHVLLRSY--P--NE--K------T-I----PHI--AS-E-------------------------L------PRLCTFAGRTMEAVTITL-------------------- 272 ----------------------------------------------------------------------------------------------------------------------EWDHKFFGISEM-AAVEMDPQQRMVLDCVHMALEDGGIRR--------QDIDG--SYTGVYI---------------------------------------G-SMNDDF--KIGA-MV-----------C----P--E-KFGAYTVTGLNSSIISARVAYVYNLHGPA------VTLDTACSSSLVAINIAEHALKLGTCDAAICGGVNSIEDS-VPFVALSKARMLSPTGQSKPFSAAAD--------------------------------------------------------------------GYARGEGCGIIILKRLS-E--------------A--VKDGNKIWG-TLR-SGSN--QDGQTAT-------P---ITSPSGSMQLDLLQRLYTE-S-KVDK-HSVQVIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEANALG-KFFG-KT--G-AA---------------------------------------------------------------T-----K-KTFIGSVKSN-IGHTEAAAGVAGLTKILLMMKYGQIVPSLL-VT-EA--S--INPKIN-LDLYGFEIPF--KTR-HWNR--P-Q--D-GRRIACVNSFG-FGGTNAHAIVHEH------------------------------------------------------------------------------------------------------ 273 ------------------------IAIVGLGCRFP-G-A---DNADEFWQVLV-NGENHV-NEIT-N--D-RW-NHDA--YYS----ENKDEVGKY-YVKKAGFL-----K-N--HD-EWDHKLFGVSES-EAGRIDPQQRYVLECTHMAMEDGGITK--------EDLKG--SQTGVYI---------------------------------------G-VMNTDY--NSLC-EQ-----------D----G--D-AVSNYCATGKSTTIIASRVSYTYDLRGPC------MVIDTACSSAMTAIHLGSQALKSGDCTMAICGGVSSIISP-ASFIVLCKTRMMSSVGQCQAFCDTAD--------------------------------------------------------------------GYARGEGCGVVILKTVK-R--------------A--TEDRNKIWA-ILR-TGCN--QDGHAAY-------P---ITAPSGEQQENLLRQVYTK-F-SVDP-MTLQYIEMHG-----------------------------------------------------------------------T-GTPI------G------DPTEVNAIE-KFIK-SY--NP-T--ERNNTSNISKHNN----TENKDMGAVQIIS--------------------------VPS--Q-----P-IIKIGSVKTN-IGHTESAAGVASLIKVLLMMKNGKLVPSLH-IK-NDKSN--LNKHIH-LDGYSLDVVT--NVE-DWAP--N-K--N-QERIAGINSFG-FGGSNSHSIVIQK---------------------------------------------------------------------------------N-------------------- 274 ------------------------IAIIGVGCRFP-G-A---DDLSEFWQVLS-KGENHV-KEIP-K--D-RW-NVDA--FYD----KDPNAPGKT-YVRKAGLT-----N-R--FD-EWDHRLYGISDM-EAKLVDPNQRMVLDCVHMALENGHMTR--------KDIDG--THTGVYI---------------------------------------G-VMNNDF--KAHV-IE-----------D----I-DP-ATAAYAMTGVHNSIVSARVSYVYNLLGPA------ITLDTACSSSLVAINIASQALRQGECDIAICGGVNCIMDP-SVFIALSKARMLSPTGQCQTYSADAD--------------------------------------------------------------------GYARGEGCGIVILKRVA-D--------------A--LQQENKIWS-TVK-TGSN--QDGHTAT-------P---ITAPSGTQQTDLLQRVYRQ-Y-KVDK-SKVQVIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEANALG-GFFS-GD--N-VI---------------------------------------------------------------K-----D-KVYIGSVKSN-IGHLEAAAGVAGLIKVLLMMENGTIVPSLM-YT-KE--N--ENPKLN-LDKFGLVVPT--KIA-TWPT--K-G--N-QKRIACVNSFG-FGGTNAHAIIEQWQ----DD--D------L-S---S-S------------------PL-KGHT--E--V-S------HKIVTISAPEEKAL-----------------------K 275 ------------------------VVISGVSCRLP-Q-S--D-NMEEFRDNLM-NGVDMV-TE---DDS--RW-QPGM--------------Y--G-LPARSGKLK--------DLTR-FDAAFFGVHPK-QANSMDPQLRLLLEVTHEAIVDAGVNP--------ESVRGS--KTGVFI---------------------------------------G-ASASES--HEAW-SA---D------------P--D-NTVGYSMTGCTRSMFANRLSYAFDFKGP------S--------------------------------------------------------------------YSIDTACSSSLLALDQALHSIRSGQCDAAIVGGSNLCLKPTTALQFLKLGMLSPD-GMCKSFDAEGNGYCRSEGIVVMYLQKEM-T--------------A--KR----VYC-TLVHSKTN--SDGSKQQ-------G---ITFPSGEVQKSLLYDVYSE-A-CINP-SEVAYVEAHG-----------------------------------------------------------------------T-GTQA------------GDPQEVNSIC-DVFC-K--D---R----------------------------------------------------------------Q----G-PLKIGSVKSN-MGHSEPASGLAAVAKVIVAMEEKTIPGNLH-Y---N--T--PNINIPGLVDGKLNVVD--CDT-KWDG-----------GLVGVNSFG-FGGSNVHSVLKSN----SQH---------A-S----QCE--SC-E-------------------------K------RRLFLYSSRSEKGLKEV--L------------------ 276 ------------------------IAIVGIGCRTP-G-A---DNIREFWKLLS-NGECHV-GGVP-H--D-RW-NSKA--YYD----PDPMAPGKA-YVQRGGFI-----R-H--PE-GFDSALYGINDF-EASHVSPQQKFLLDCTNMALEDAGITK--------TQISG--TNTGVFV---------------------------------------G-SMNNDH--LATF-LG-----------H----N--N-KVATHTVTGTSTTILSARLSYVFNLLGPS------MVLDTACSSSLVAIHLGCQAILTGDCNMAICGGVNAMQIP-DVYVQLSKARMISPTGLCQTFSDKAD--------------------------------------------------------------------GYIRGEGCGVVILKRLE-D--------------A--LHDGDKIWA-TVC-TGTN--QDGHTVS-------P---MTAPSGEQQKKLLHSVYGK-F-GVDV-ANLDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEVNALG-EFFK-QA---G----Q------------------------------------------------------------P-----R-DRYIGSLKTN-I----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 277 ------------------------IAIIGIGCRAP-G-A---NNISEFWRMLE-RGENHV-LDIP-P--E-RW-NARA--YYD----PDPMTPGRS-YVMKAGLV-----K-S--PE-AFDNRLYGINDL-EAIHVDPQQRFVLDCVTMAMEDAGITR--------AMMKG--SRTGVYM---------------------------------------G-VTNSDY--RSLF-PS-----------Q----S--S-DINNYTVTGISNSIIAARVSYVWDLRGPS------LVLDTACSSSLIAMHLGIQAIRTGDCDVAICGGTNYLTLP-DIFVFLSKARMISPGGQCRPFSADAD--------------------------------------------------------------------GYARGEGCGVVILKRLC-D--------------A--ERDGDNIWA-TIS-TTSN--QDGHTVT-------P---LIAPSGQQQQQLLCDMYSS-L-GEDV-DNIDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEAEALG-TVFE-RC---G-A--Q------------------------------------------------------------V-----R-DRFVGSVKSN-IGHLEPAAGVMGVIKVLLMMRHGKIVPSLF-FS-----Q--PNPRIN-FSALHLTVPT--KVH-EWKG--T-------QKVAVCNSFG-FGGSNCHAVLKEYS----AN--A-V------H---T-GS---------S-----------RSQ-----K-S------PCVVCFTANTERS----L-------------------- 278 --------------------------------------------------------------------------------------------------------------------D-EWDNRLFNINDF-EMNQMDPQQRLVLDCTYMALENAGITR--------AHLAG--SDTGVFV---------------------------------------G-AMNSDY--RGLF-TA-----------A----S--T-IVGNYTATGVSNSIIAARVSYVFDLRGPS------VTVDTACSSALVSIHLGAQAIRSGDCNLAICGGTNYLTLP-DVFVHLSKAHMLSPTGQCHAFSDKAD--------------------------------------------------------------------GYTRGEGCGILILKRLK-D--------------A--ERDGDNIWA-TIL-TGSN--QDGRSVT-------P---MTAPSMSQQVRLLEQVYSN-A-NIDI-DRLDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPIEATAVG-NFFK-DH---G-A--M------------------------------------------------------------G-----R-VRYIGTVKTN-LGHLESAAGAVGIIKVLLMMRHSLIVPSLH-FA-NN--N--PNPRID-FEELQLQVPT--KVL-EWSR--E-------NKIGCVNSFG-FGGTNGHCILIEYT----KR--R-S------S---S-AV---------LD----------AAL-----K-K------PCIVCLSANSEKS----L-------------------- 279 ------------------------IAIVGIGCRFP-G-A---NNIKEFWEVLV-NGENHV-KEIP-G--D-RW-NLDA--IYD----PDPDAYGKT-YVRRAGLL-----S-D--HD-AWDNAFFGIAEK-EASEMDPQQRYVLECVHMALEDGGITR--------AELDG--SRTSVYI---------------------------------------G-AMNSDS--KTSK-DG-----------D----Y--S-LMTNYSVTGDAASIITARVSYNYNLLGPS------LTIDTACSSSLVAVNLATQSLRLGESSMAICGGVNSILYP-DMFITLTKARMASPTGQCQAFSANAD--------------------------------------------------------------------GYARGEGCGIVILERLS-D--------------A--LKNDRHIWA-TIR-TGCN--QDGQTAK-------P---ITAPSEIQQRRLLHDIYLNSY-NIDP-SDVQYIEAHG-----------------------------------------------------------------------T-GTPI------G------DPVEVKSLG-SFFK-EY--PIQD---S----D---------------------------------------------------E--K-----K-QRYIGSVKTN-IGHLESAAGAASLIKTLLMMKHGQIVPSLH-SL-----P--RNPMID-FVNYNLDVPT--IGQ-SWST--L-S--D-GSRAACINCFG-FGGTNSHAFIKQW------------------------------------------------------------------------------------------------------ 280 -------------------------LIAGIACRLPK--S---SNLQEFWENLI-ESRDMI-G-------KTRF-PEG---LDG--------------VPPRAGLIP------D--ID-KFDAGYFGFTD-IEADSMNVMLRHLLEVTYECVVDSGLQE--------ATLQDN--ATGLYL---------------------------------------A-CFLPDT--DPI-ET---------------------TKN-SKTKLCTTTPFLTGQMASYFGWNGPA------VSVDTACSSSLSALEMADTDLKTGRCQFAVVASVNVIINP-VYLQQMAILGMLNPTGESKVFDRDAG--------------------------------------------------------------------GYVRAEGVAAIILTRKE-S---------------LCRH----IYST-VVDVMTN--CDGYTPE-------G---ISFPNNLMQKTLLEAIYK-R-AGVDS-DQLAYMELHS-----------------------------------------------------------------------T-GTKV------G------DKVEVGAVT-DVLC-PG--R------------------------------------------------------------------S-----T-PLPIGSVKGN-MGHSEATAGLASLMKCLLVARHR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 281 ------------------------IVIVGVGGKFP-G-A---DNIDEFWQVLR-DGENHV-IEIP-S--D-RW-NLEA--FYH----EDPDEPGKT-YVRKAGLL-----K-G--YD-QFDNKQFGISDI-EAARMDPQQRYVLESVHMALEDGGITK--------KDIHG--TQTGVYI---------------------------------------G-VMNDDY--RITC-CD-----------D----L--K-RTSNYTLTGTSPSIIPARVAYTYNLLGPA------MTIDTACSSSLVAIHVAAQALRCGDCNIAISGGVNSILYP-DMFVPLSRARMVSPTGQCQAFSNKAD--------------------------------------------------------------------GYARGEGCGILILKTRK-Q--------------A--MLDGSKIWA-SIA-TGIN--QDGRTTT-------P---MTAPSTVQQMNLLKQVYSA-T-GCDP-RTVQYLEAHG-----------------------------------------------------------------------T-GTPV------G------DPKEANTLG-EFFA-AN--NV-E--DD----E---------------------------------------------------C--R-----T-AVLIGSVKTN-IGHLESAAGVAGVIKVLLMMKHGKIVPSLH-VQ-S------PNPKID-LENYNLEIAQ--HLT-DWPY--L-P--GGRTRLSCVNSFG-FGGTNSHAIIKQEK----------------------------------------------------------------------------------------------------I 282 ------------------------IAIIGIGCRFP-G-A---SCLRDFWKVLV-NGENHV-VEID-D--E-RW-NQDI--YFD----KDPRTPGKT-YAPRAGFI-----K-N--YA-HFDFKMFGINEH-EAALMDPQQRQVLECTYMALEDAGITR--------QQIAG--QEVGVYI---------------------------------------G-CMNNDF--TQMS-NK-----------H----P--Y-LVDNYSVTGTAVSVVSNRVSHIFDLRGPS------MTIDTACSSSVVALHQAGLAMKAGDCSMAICGGVNLLLNG-GVFVPLSKAQMLSPTGQCHTFSANAD--------------------------------------------------------------------GYTRGEGCGIVIIKPLK-Q--------------A--MKDGDNIWG-TIA-TGLN--QDGHVAK-------P---LTAPSGEQQAQLIQDVYSK-H-AIDT-TSIDYIEAHG-----------------------------------------------------------------------T-GTKI------G------DPVEVNAFG-HFFL-KQ--QQ-S--K------------------------------------------------------------R--------RYIGSVKTN-IGHLESAAGVAGLIKVLLMMKHSTIVPSLH-FD-KP------NEAID-FDRFQFVVPT--EPV-PWLP--D-------QKVACLNSFG-FGGANSHAIVKNSS----NG--Q-T------K---S-T----Y-S-----------------C-----T-K------PVVVCFSGSNQQTLK--K-------------------- 283 ------------------------VVISGISGRLP-E-S--D-NMEEFRQHLM-LGEDMI-TE---DDR--RW-PTGL--------------H--G-LPAGMGKLK--------DISK-FDASYFGVSPK-QADLMDPQVRMLMETTYECIVDAGVNP--------QSLRGS--KTGVFI---------------------------------------G-ASFSEA--AEAF-AA---N------------T--E-KNIGYALTGCCRSMFANRISFFFDLKGP------S--------------------------------------------------------------------YTVDTACSSSLLALDQALQSIRMGHCDAAIVGGSGLCLKPASSMQFMQLGMLALD-SRCKSFDASGNGYVRSEAVSTVFLQKAS-D--------------A--RR----IYA-TVVHSGTN--TDGNKER-------G---ITFPSGKVQKQLLERVYSE-A-CINP-ATVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPEEANAII-DVFC-K--G---R----------------------------------------------------------------Q----G-PLLVGSTKSN-MGHAEPASGLASVAKVLIAMEDGVIPPNLH-Y---S--E--PNPDIAGLLDGRLEVVT--ECR-RWDG-----------GYVGINSFG-FGGANVHAILKSH--D--QE--R------I-G----AHP--DA-E-------------------------S------IRLFTYAGRTEETVRHVF-------------------- 284 --------------------------IAGVGVRLP-H-A---NNLDELSDILQ-NKCCIL-T--E-P----RW-ASQ---LYG--------------MHHLCGLIN------P--IG-MIDCEEFEMSL-EEAACANPMLGPLLEVVAECMLDAGFVK--------GNISKY--RTGFYL---------------------------------------G-LTFCDT--DVL-IT---------------------NKTDTTSNFMNTRTELCARVSHLFNLKGPV------MQVDGACASSFAAMHAALLDLHSGRCELAIVAGSNLLLDP-TVSLQFEKLKMLSPSGNSAPFDDSAD--------------------------------------------------------------------GYVRSEGIAAILLKPAK-S--------------EIISK----AYCD-VVGFGLE--CDGAREK-------G---MLHPNSTFQYHLLSNVYS-K-YNINV-DDIVFFEAHG-----------------------------------------------------------------------T-STQK------G------DKAELSAID-KAVC-SK--R------------------------------------------------------------------T-----K-PLLVGSIKGN-IGHTEASAGLAGILKCLASYRRKLIFGNVN-MN-----T--PNRSISSLHTGNIVIPI--STN-PLPK----E----GPNLMCVSSYG-FGGLGGHIVLSPCR----PL--D-Q------T---R------------------------------------------------------VTYP--V------------------ 285 --------------------------ISGVGCRLP-E-S--D-SIAEFSEHLM-NGDDMV-TE---DNR--RW-EPGL--------------Y--G-LPRRSGKLK--------DITK-FDAFFFGLSPR-QTNNMDPQMRILMETAYEAIVDAGVSP--------YRLRDS--RTGVFV---------------------------------------G-CSSSEA--YEAW-SN---D------------P--E-NIDGYTMIGGQRSMLANRLSFAFGFRGP------S--------------------------------------------------------------------YAIDTACSSSLLALDQALLSIRLGYCSAAIVAGCSLCLKPQSAQQFNKLNMLSED-GACRSFDASGSGYCRSEAVVALFLQQVS-V--------------A--NR----LYM-TIVHTKNN--ADGAKEQ-------G---ITYPSGEVQECLIHEVYND-A-GINP-KNVAYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNAIA-NVFC-V--G---R----------------------------------------------------------------K----G-PLLIGSTKSN-MGHPEPASGLAAVCKVIIAMESGVIPANLH-Y---D--T--PNPGIPALSDGRLQVVT--KNI-PWKG-----------GIVGVNSFG-FGGSNVHAILESN--H--FV--N-N----R-T----WHT--KA-G-------------------------D------LRIAIASGRMETGVERML-------------------- 286 ----------------------------------------------------------AI-TA---G--------------------------------------------------------------------------------------AGVSP--------YSMRGT--KTGVFV---------------------------------------G-CSTSES--HEAW-AT---D------------T--E-NIDGYTMIGCQRAMFANRLSFYFDFRGP------S--------------------------------------------------------------------YTIDTACSSSLLALDQALVSIRLGYCDSAIVAGCSLCFKPQTAQQFHKLSMLSEY-GACRSFDASGAGYCRSEAVVAVFLQHIS-V--------------A--NR----MYM-TVVHSKSN--ADGYKEQ-------G---ITFPSGELQEVLLREVYAD-S-GIKP-RDVAYLEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNAIA-SVFC-E--G---R----------------------------------------------------------------D----T-PLLIGSTKSN-MGHPEPASGLAALCKVIIAMESGTIPANLH-Y---K--D--PNPEIPALMDGRLKVAS--ENT-PWRG-----------GIVGINSFG-FGGSNVHVILE-------------------------------------------------------------------------------------------------------- 287 --------------------------------------------MAEFRDHLF-NGDDMV-TE---DNR--RW-EPGL--------------Y--G-LPRRHGKLK--------DISK-FDTNFFGLSPR-QTNNMDPQLRMLLEVTYEAIIDAGVSP--------HTMRGT--RTGVFV---------------------------------------G-CSSSEA--YDAW-TS---D------------P--E-NIEGYTMIGCQRAMFANRLSFFFDFRGP------S--------------------------------------------------------------------YTMDTACSSSLLALDQALLSIRLGYCNAAIVAGCSLCLKPQTAQQFNKLSMLSDY-GACRSFDASGAGYCRSEGVVAVFVQQIS-V--------------A--NR----LYM-TVVHTKNN--ADGSKEQ-------G---ITFPSGEVQESLIREVYSD-A-GIDP-RTVVYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNGIA-NVFC-E--N---R----------------------------------------------------------------D----T-PLLIGSTKSN-MGHPEPASGLAAICKIIIAMENGAIPANLH-Y---T--T--PNPEIPALLDGRLKVVA--TNT-PWDG-----------GIVGINSFG-FGGANVHAILESN--S--LA--N------R-T----WHG--GA-G-------------------------D------MRLSVASSRTEQGVARLL-------------------- 288 ------------------------VVITGISCRLP-E-S--D-NMAEFRQHLV-NGEDMV-TD---DGR--RW-QPGL--------------H--G-LPHRSGKLK--------DLTK-FDCSFFGVNPK-QANAMDPQLRLLLEVAYEAIIDAGVNP--------QSARGS--RTGVFI---------------------------------------G-ASASEA--HEAW-SS---D------------P--E-KTVGYCMTGCQRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------FTMDTACSSSLLAMDQALMNIRLGMCDSAIVGGSSLCLKPETALQFMKLGMLSPD-GACKSFDESGNGYCRSEGIVVVLLQKKS-D--------------A--KR----IYS-SLVHSKNN--ADGNKEQ-------G---ILFPSGAQQKKLIKEVYSE-S-GVNP-VDVQYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNSIA-DVFC-P--G---R----------------------------------------------------------------E----E-PLLIGSTKSN-MGHPEPASGLAALAKLVIAMEDGVIPKNLH-Y---K--S--PNPDIPALADSRLKVVS--EPT-TWKG-----------GFAAINSFG-FGGTNVHAVLKSN----SC---V-K----R-D----AHE--AA-N-------------------------S------KRLFLCSSRTQEGLDEIL-------------------- 289 ------------------------VVVSGISGRLP-E-S--D-NLEEFREHLV-LGEDMV-TE---DNR--RW-EPGF--------------L--G-LPRRFGKLK--------DISK-FDASLFGISPK-QANNMDPQLRLLLEVTYEAIIDAGVNP--------QSLRGS--RTGVFI---------------------------------------G-VSASEA--HDAW-SS---D------------A--E-TTVGYCMTGCQRAMFANRISFFFDLRGP------S--------------------------------------------------------------------YTVDTACSSSLLAMDQAVLNMRLGYCDTAIVGGCSLCLKPQTALQFMKLSMLSPD-GTCKSFDASGNGYARSEAVSAVLLQKST-E--------------A--KR----IYT-TIVHSKNN--ADGNKEQ-------G---ITYPSGEVQKVLVKSLYDE-A-NISP-LEVTYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEINGIT-DVFC-P--G---R----------------------------------------------------------------E----G-PLLIGSTKSN-MGHPEPASGLAALSKVIIAMEDGMIPANLH-Y---T--S--PNTDIPGLVDGRLKVVT--ERT-RWES-----------GYAAINSFG-FGGSNVHVILKRN----SQE--P-A----Q-E----RHV--DA-D-------------------------K------KRIFISSSRTQEGLEKVL-------------------- 290 ------------------------VVISGISCRLP-E-S--E-NMEEFKKHLM-RGDNMI-TE----NR--RW-EPAA--------------H--G-LPSKSGTLV--------DISK-FDAAFFGVPPK-LADSMDPQLRIMLELTHEALVDSGVSP--------ATIRGS--NTAVYI---------------------------------------G-CGMSEA--WEAL-ST---D------------N--S-NVTGYSPLGCTTSMFANXX-----------------------------------------------------------------------------------------------------------------------XXMKPATSVQLAEMNFLSMD-GHCRCFDERGEGFGRSEGVVVMCLQKKA-Q--------------A--KR----VYC-TVIHSKSA--TFTTENN-------N---FNFPNFEEERQFLHETYRE-A-RLDA-SHISYMETGS-----------------------------------------------------------------------S-CTKM------------SDTIELNAIS-DVIC-K--N---K----------------------------------------------------------------S----K-PLLIGSVKSN-IGHTEATSGLAAVSKIIIAMEDGVIPPNLH-F---N--M--PN-----IQNEQIKVVS--ERT-RLNG-----------EYCAVNSFG-LGGVNVHTILKSY----DK------------------------------------------------------------------------------------------------ 291 ------------------------VVISGISCRLP-E-S--D-NVEEFRQHLI-NKDDIV-TE---DER--RW-PKGI--------------Y--G-LPPRNGKLK--------DVSK-FDASFFGVHPK-QANSMDPQLRLLLEVTYESIVDAGINP--------DSIRGS--KTGVFI---------------------------------------G-CSASEA--HDAW-SC---D------------P--E-KTVGYSMTGCTRSMFANRLSFFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLLAMDQALHSIRQGNCDAAIVGGCNLCLKPTTSLQFQKLGMLSKE-GTCKSFDASGDGYCRSEGVVVIYLQKNE-A--------------A--KR----IYS-TIVHSKTN--SDGNKEQ-------G---ITFPSGSVQKQLLQEVYSE-A-CIDP-STVEYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQELNTIT-DVFC-K--D---R----------------------------------------------------------------E----T-PLLIGSVKSN-MGHPEPASGLAAVTKLIIGMEDKMMPANLH-Y---E--S--PNTDIPGLVDGRLQVVT--DRT-PVNG-----------GLMAVNSFG-FGGSNVHAVLKP--NID--N--E-------------NES--CD-L-------------------------S------KRLFLYSSRTHEGVEKVL-------------------- 292 -------------------------VIAGLSCRLPK--S---NNVEEFWDNLI-KRKDMI-E-------ETRW-PLG---LYD--------------TPPRAGLIK------D--ID-KFDARFFKFTD-TEADNMNPLLRHLFEVTYECIADSGIPL--------HVLSSN--TTGTYT---------------------------------------A-CFIPDN--DPL-ET---------------------SRC-ADSKYCTTVSMITGHLMNQFKFTGPS------ATVDTACSSSMSAMEMAVTDLMTGRCQFAMVTGCNLLLNP-SYLQQMCFLGMLSAEGQSRVFDADAK--------------------------------------------------------------------GYVRAEGIVSILLTRQA-N---------------LCQR----IYAS-VVDVKTN--CNGYNPD-------G---ITFPSKDCQCALMIEVYK-R-SDIKT-EDLAYMELHS-----------------------------------------------------------------------T-GTPV------G------DPIEVRSVT-EAIC-ST--R------------------------------------------------------------------E-----K-PLLIGSVKAN-MGHSEATAGLASLVKCILAARHGVIPPQRN-FK-----K--PNPNIESFKDGKVIVVN--EPT-ELKD----G-------YIGLNSFG-FGGSNGHVILKPFR----RK--K-K------A---V-A--------KQ----------------------F-------CLVPVTARTDSEKESIM-------------------- 293 ------------------------VVISGISCRLP-Q-S--E-NMEEFKKHLF-AGDNMV-SE----NK--RW-DSVS--------------H--G-LPSKSGTLE--------DISK-FDAAFFGVPPK-LADNMDPQLRMMLELTYEALIDSGISP--------ATIRGT--NTGVYV---------------------------------------G-CGLSET--WEAL-ST---D------------D--S-HVTGYSPLGCTSSMFANRISFAFDFRGP------S--------------------------------------------------------------------FALRNGCASGLLALDRAVTSIRNGDCDVAIVAGCNLCLKPATSVQLAEMGLLSSH-GECRCFDERVDGYGRSEGVVVMCLQKKV-K--------------A--KR----VYC-TVIHSKSS--SFTTENN-------N---INYPSFEEERKFLEDTYRE-A-RLNP-SHIAYIEANS-----------------------------------------------------------------------S-CSKM------------ADSIEINAIA-DVIC-R--N---K----------------------------------------------------------------T----K-PLLIGSVKSN-IGHTESTSGLASVSKIIIAMEEGVIPPNLH-C---N--I--PM-----TRNEQVKVVT--EKS-RLNG-----------EYCSVNSFG-LGGANVHTILKTF--N-DRN--N--------K----YHF--AN-E-------------------------K------KRLCVYSARTKHGLESIF-------------------- 294 ------------------------IAIVGVGGKFP-G-A---DTIDDFWQVLV-KGENHV-IEIP-P--E-RW-NVEE--YYS----KDYDEPGKT-YVRRAGFL-----Q-N--FD-EFDPKMFGISEP-EAAKMDPQQRYVLDCVHMALEDGGILR--------KDLDG--SRTGVYI---------------------------------------G-VMNDDY--KSSA-TE-----------D----P--S-VASNYTLTGTAPSIIAARISYVYNLLGPS------LSIDTACSSSLVAIHLASQALKSGDCSMAICGGVNSILYP-DIFIPLSKARMVSPTGQCQAFADTAD--------------------------------------------------------------------GYIRGEGSGVIVLKKLK-D--------------A--IRDGNKIWA-TIA-TGCN--QDGRTMT-------P---ITAPSVQMQTELLQEVYES-N-NLHP-SLVQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEANSLG-EFFK-Q------Y--RD----G---------------------------------------------------I--P-----R-PIKIGSVKTN-IGHLESAAGVAGIVKVLLMMKNGKTVKSLH-FK-R------PNPKID-FQKYNMAVTT--EVD-EWPT--M-E--D-GTRVSCVNSFG-FGGTNSHAIIKQFP----VN--N------A-S---E-V--------EN------D-I-----------H-R------KYIVFLSALDNGG------------------------L 295 ------------------------VAVVGLGCRFP-G-A---DNVDEFWQVLK-NGENHV-IEVP-A--N-RW-NLDA--FYD----EDPTTPGKT-NVRRAGFV-----K-E--HD-YWDYKFYGINEF-ESLRMDPQHKFILDSTYMALESAGITR--------KEIKG--SNTGVYV---------------------------------------G-IMNSDY--STNF-AE-----------S----F--G-DFDNHTITGTNNSIVSSRVNYTFDLHGPS------MTIDTACSSSLMAIHHAHQAIITGECDMCIAGGVNALLKP-DNFIQLSKAGMVSPTGQCQAFSENAD--------------------------------------------------------------------GYARGEGCGMVILKSYE-K--------------A--LEDNDPIWA-TIS-TASN--HDGHTVS-------P---ITTPSMQQQIRLLNIVFKR-F-DVDR-QTIDYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPVEVKALG-TFFQ-----------------------------------------------------------------TE-EN--S-----T-PKIIGSVKTN-IGHLESAAGVAGLIKVILMHQHHEIVPSLH-FE-----R--PSPEVP-LEEYRFTVPV--KSN-EWPE--TE---R-DYLRSSVNSFS-FGGSNCHAIVTTPK----TK--C-M------R---L-FS--G-----H--DTP-------------------------KVLCISAIEPPSLRK-I-------------------- 296 ------------------------IAIVGISCMFP-G-A---ENLEEFWKVLI-YGEDHV-QTIP-P--E-RF-IVEA--FYD----PNPDHPHKT-YVKKAGLI-----K-K--HD-EWDNKFFGISDK-EAEQVDPQQHFLLESVHMALEDAGIPK--------EKIAG--SDTGVYI---------------------------------------G-AMNHDW--KCVL-RS-----------A----R--C-ESTNTTVTGADSSILSARIAYFYNLLGPA------ITLNTACSSSMVAFHMASQALKNGEISMAIAGGVSFILDP-EVFINLSSARMASPTGKCHTFSQNAD--------------------------------------------------------------------GYARGEGCGIVIMKRLA-D--------------A--LYDRNKIWG-ILF-TGLN--QDGHTSS-------P---ITSPSGEQQQKLMESVYRR-S-GISP-HSVQYIEAHG-----------------------------------------------------------------------T-GTSV------G------DFTEVAALG-SFFS-NH--S------------------------------------------------------------------L-----H-EIYIGSVKAN-IGHLESGAGVAALIKVLLMMKNGLYVPSLH-AQ-P------LNPNIS-FSHYMFKVCQ--EVQ-RWEQ--N-E--N-GNRIAAINCFG-FGGTNAHAIVTDYK----E---K--------------QQ---------------------------------------------------------------------------K 297 ------------------------VAVTGISGRLP-E-S--G-NIAEFRENLI-QGIDMI-TE---DDR--RW-TPDL--------------F--E-LPKRNGKLK--------ELDK-FDAGFFGLPPK-QADAMEPQLRMLLEVCYEAIVDAGFDP--------TSLRGS--KTGVFV---------------------------------------G-ATESEA--HQAW-SS---D------------P--E-MTVGYHMTGCARSMFANRLSYYFDFKGP------S--------------------------------------------------------------------FVMDTACSSSLLAMDQALTSIRLGLCNAALVAGTSLCLKATTSLQFKKLNMVSED-GCCRSFDASGSGYVRSEAVVGVFLQKAK-H--------------A--RR----VYA-TLIHSKNN--ADGNKEQ-------G---ITFPSGKIQKRLLTEVYEE-A-GIDP-KNVAYVEAHG-----------------------------------------------------------------------T-GTQA------------GDPQELNSIT-DVFC-K--G---R----------------------------------------------------------------E----G-PLLIGSTKSN-MGHPEPASGLAALAKVLIAMEDGMIPANLH-Y---K--E--PNPQIPGLLDGRLKVVT--ERL-PWNG-----------GYVAINSFG-FGGSNVHVLLKSY--P--NE--K------L-T----PHP--AS-E-------------------------L------PRLLTYAGRSQEAVSTIL-------------------- 298 ------------------------VVISGISGRLP-E-S--A-NIEEFRENLI-QGVDMV-TE---DDR--RW-TVGL--------------Y--D-LPKRNGKLK--------EIDK-LDAGFFGLPPK-QAHAMDPQLRILLEVSYEAIVDAGFDP--------ASLRGS--KTGVFV---------------------------------------G-GSESEA--HQAW-GA---D------------P--E-KTVGYNMTGCARSMFANRLSYYFDFKGP------S--------------------------------------------------------------------FLMDTACSSSLLAMDQALAHIRLGVCDSALVAGTSLCLRPTTSLQFKKLNMVSED-GCCKSFDASGSGYVRSEAIVAIFLQKAK-N--------------A--RR----VYA-TLVHSKNN--ADGNKEQ-------G---ITFPSGEIQKRLLTEVYQE-A-GVDP-KNVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEINAIT-DVFC-K--G---R----------------------------------------------------------------E----D-PLLIGSTKSN-MGHPEPASGLAALAKVLIAMEDGMIPANLH-F---K--D--PNPDIPGLLDGRLKVVT--ERL-RWNG-----------GYVAINSFG-FGGSNVHALLKSY--P--NE--K------T-M----PHP--AS-E-------------------------L------PRLLTYAGRTQEAVSTVL-------------------- 299 --------------------------LAGVASRLPE--S---ENIDEFWENLI-LGKDLI-R-------GTRW-PRE---LHG--------------TPPRVGLIK------N--ID-KFDAEYFNFEE-NEVHHMNPMLRHLYEVCSECVVDSGLSL--------SVLQNN--TTGIYL---------------------------------------A-CFLPDS--DTL-ET---------------------SRE-AISKLCTTVPMMAGHLMEYFGFSGPM------MTVDTGCSSSLSALEMAVSDLNAGKCQFAMVTGANLLLNP-SYFQQMMQLGMLNPSGHSNVFDAKAG--------------------------------------------------------------------GYVRAEGVVAVLLTRNI-T---------------ICKR----VYLS-ISDILTN--CDGFKTE-------G---ITFPNSQSQAKLMSTIYS-R-DDIDV-NDIAYVEAHS-----------------------------------------------------------------------T-GTKA------G------DPVEANGIV-QALC-EG--R------------------------------------------------------------------H-----K-PLLVGSVKAS-MGHSEATAGLASLVKCIMIARHGTIPPQIN-YD-----S--PNPKIDGITQGKVKVVD--QAM-PLAD----G-------YISLNSFG-YGGANGHAVLKPFR----KQ--H-T------T---N-K--------DV----------------------S------HSLVTIHTRNEREMESVV-------------------- 300 ------------------------IAVIGIGCRFP-G-A---NNIDEFWRVLV-NGENHV-VDIP-S--Q-RW-NNDA--LYS----EDKDEPGKL-YVKEAAFI-----N-R--HD-EWDNRLFSISDN-EAAQVDPQQRYVLECVHMAMEDSGILK--------KQLHG--SDTGVFI---------------------------------------G-AMNCDY--LNLF-DF-----------D----H--D-GDTNYSATGTSNTIISARVSYVYNLQGPS------MVIDTACSSSMTAVHLGCQAIRAGECEMAICGGVASILSP-GLFISLCRAKMLSPTCQCQAFCDTAD--------------------------------------------------------------------GYVRGEGCGVLFLKSYK-K--------------A--IEDGNKIWG-ILK-TGVN--QDGRMTQ-------P---LTAPAGKQQEQLLKKIYSR-F-NVNP-LDLQYIECHG-----------------------------------------------------------------------T-GTPI------G------DPTEVNALG-NFIQ-SY--R---------DQALSPKTK-N-------NCADKTSVEKSRATSGFLQKQN-------------------------KILIGSVKTN-IGHLESAAGIAGLIKVLLMMGKGKFVPSLH-VR-KDKSN--LNKKIK-FEDFGLDVSV--NVS-DWPP--N-A--D-GQRVCCVNSFG-FGGSNSHAVIIQ----------------------------------------------------------------------------------K-------------------- 301 ------------------------IAVIGIGCRVP-G-A---DNIGEYWRVLS-NGENHI-IDIP-K--E-RW-NNEA--FYS----ENKDEPGTT-YVKKAGFI-----S-R--HD-EWDNKLFGVSDS-EALHVDPQQRLALECTHMALEDAGITR--------QQIKG--TETGVYL---------------------------------------G-VMNDDY--KSLS-SF-----------D----H--D-EDTNYSATGMSSTIISARVSYVYDLRGPC------MVIDTACSSSMVAIHLGSQAIRSGDCEMAICGGVSSILIP-DQFITLCKARMLSPSGQCQSFCDTAD--------------------------------------------------------------------GYGRGEGCGIVILKSYK-Q--------------A--VNDKNNIWG-IVK-TGSN--QDGRVAQ-------P---ITAPSGQQQEELLRKVYNL-Y-EIDP-SSLQYIEAHG-----------------------------------------------------------------------T-GTSI------G------DPTEINAIG-RFIE-SF--K---------LKRPPDKQ----------DERKNILSTS-QLRNSQNKSDAQDANKCLPTN-DV----------K-TILIGSVKSN-IGHLESAAGVAALIKVLLMMKYGKFVPSLH-VK-KDKSN--INKKIA-FETYGLDISL--NLA-DWKP--D-K--N-GERICCVNCFG-FGGSNTHAVVIQNE----HM--A-S----S-----L-HS-------------------------------------------------------S-------------------- 302 ------------------------IVIVGVGCKFP-G-A---DNLDEFWRVLS-EGENHV-IEIP-R--E-RW-NLDA--FYD----KDPDIPGKT-YVRHAGLL-----K-R--FD-EWDHKFFGINEV-EAARMDPQQRYVLECVHMAMEDGGITK--------KDLNG--SDTGVYI---------------------------------------G-VMNDDC--KGST-SD-----------D----F--R-TMNNYTVTGTAGSIVSARVSYTYNLLGPS------MTIDTACSSALVAIHVASQSLKSGECRSVICGGVNSILSP-DMFVPLSKARMVSPTGQCKSFSDKAD--------------------------------------------------------------------GYTRGEGCGIVILKTKK-Q--------------A--IHDGNKIWA-TIA-TACN--QDGRTMS-------P---ITAPSGTQQLQLLQRLYAD-Q-GVDP-KDVAFIEAHG-----------------------------------------------------------------------T-GTPV------G------DPVETNTLG-KFFA-DN--L--N--D-----T---------------------------------------------------C--Q-----C-NVYLGSVKTN-IGHLESAAGVAGLIKVLLMIQHGKIVPSLH-FD-K------PNPNID-FAQYRLKIPR--TIC-PWPC--P-A--EGRERLSCINSFG-FGGTNSHAIIKQYH----GH--S------C-R---K-L--------VK------P-------------R-E------DQIIAISGNDITSLRKS--------------------L 303 ------------------------IVIIGAGFKGP-G-A---ENLEEFWALLE-KGENKL-VDIP-K--E-RW-NHDS--FYD----PERMRLGKT-YATKAGLV-----E-R--PY-EFDNTLFNINEV-EADQTDPQQRWALECSYRAIEHAGLTR--------EMLQG--SNTGVYI---------------------------------------G-AMNCDY--RSLF-PA-----------R----S--S-TVDNYTITGVSNAIISARVSYCFDLRGPA------MVLDTGCSSALTAIHTACQALRSGDCDLALAGGTNFIFSP-DIFTHLSKAGMLSPTGQCHAFSDKAD--------------------------------------------------------------------GYARGEGCGIVVLKRLS-D--------------A--VKDKDQILA-TIA-TGTN--QDGRTVT-------P---ISAPSKEQQKRLLEKIHGH-L-SPEELDKLDYIEAHG-----------------------------------------------------------------------T-GTVA------G------DLVETTALG-EFFL-SR---N----S------------------------------------------------------------T-----N-MKYIGSVKSN-IGHLESAAGIAGLIKVLLMFQHNKIVPSLF-TD-----S--LNKNLK-FEKFNFVVPD--KVV-PWNK--K-------EKIACINCFG-FGGSNCHAIVKTIK----EQ--Y-P------R---E-EQ---------Q----------------------------------------N----L-------------------- 304 ---------------------L--AIISGVGLRLP-Q-A---NNLDELAQLLL-NKGCFT-E--Y-Q--WHRV-QSN---LYG--------------QNICHGIVD------P--MG-MMDCDFFNIPP-EEAVMCNPMLGPLLEVVAESILDSGLKL--------SDVSKH--CTGFYL---------------------------------------G-ATFCDT--DVM-VS---------------------N-LETSSNSFNTRTELSARVSHHFDLKGPV------IQFDGACASSFAALHAAMLDIQANRCEIAIVAGANLVLDP-MVSVQFSKLNMLSPTGLSAPFDESAN--------------------------------------------------------------------GYVRTDGIVAILLKSDA-S--------------HISSR----TYCS-VVGFGLK--SQGANGK-------G---ILRPSKHFQSELLEEVYE-K-FNINV-EDVVFLESHG-----------------------------------------------------------------------T-STQI------G------DKTELGAIY-KAVC-SK--R------------------------------------------------------------------T-----K-PIIVGSIKGN-IGHTEACSGLAGILKCLASYRTSTIFSNVN-YR-----T--PNSAIPALH---------------------------------------------------------------------------------------------------------------------------------------------------------- 305 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEG--SNTGVYI---------------------------------------G-CMTDDY--KGHV-LD-----------D----T--T-VSSTYSVTGTHNSIISARVSYVYNLTGPA------MTLDTACSSSLVAIKIASEALLLDTCDIAICGGVNVLLDP-QLFIALSKARMLSPDGQCKTFTAEAN--------------------------------------------------------------------GYARGEGCGIVVLKKVS-K--------------A--LQDGNKIWA-TIK-AGSN--QDGRNAS-------P---ITAPSGQQQEKLIETMYRK-H-DIDR-SIISVIEAHG-----------------------------------------------------------------------T-GTAI------G------DPTEVKALG-NHFG-TV--S-GA---------------------------------------------------------------R-------DIFIGSVKTN-IGHLEAAAGVAGLIKLLLMMKHDTIVPSLW-YT-KA--N--ENPKLS-LSKHGFNVPT--TCT-PWIK--T---NG-LERVACVNSFG-FGGTNAHAIVKEF------------------------------------------------------------------------------------------------------ 306 ------------------------IAVIGIGCRFP-G-A---DNIDEYWRVLA-NGENHI-IDIP-K--E-RW-NNDA--FYS----ENKDEPGKS-YVKKAGFI-----S-G--YD-EWDNKLFGVSDS-EAVHIDPQQRQVLECTHMALEDAGVTR--------QYLKG--TETGVYL---------------------------------------G-VMNDDY--KSLS-SF-----------D----H--E-EDTNYSATGMSSTIISARISYVYDLRGPC------MVVDTACSSSMLAIHLGSQAIRSGDCVMAICGGVSSILIP-DQFITLCKARMLSPSGQCKSFCDTAD--------------------------------------------------------------------GYGRGEGCGIVILKSYT-Q--------------A--LKDKNYIWG-IVK-TGSN--QDGRVTQ-------P---ITAPSGQQQEELLKKLYNQ-Y-NIDP-ASIQYIEAHG-----------------------------------------------------------------------T-GTAI------G------DPTEINAIG-RFIE-SH--R---------SKLPPDKQ----------NKTKRHQDALQELHFSQNKSDAQTENKCLPTN-SVKI--N-----E-TILFGSVKSN-IGHLESAAGVAALIKVLLMMKYGKFVPSLH-VK-KDKSN--INKKIA-LETYGLDISL--DLS-DWKP--N-A--K-GERICCVNCFG-FGGSNTHAVVIQN------------------------------------------------------------------------------------------------------ 307 ------------------------IAVIGIGCRFP-G-A---DNIDEFWRVLV-NGENHV-VDIP-P--E-RW-NNAA--FYS----DNPDEPGKY-YGKKAGFL-----N-R--HD-EWDNSLFGISDT-EAVRIDPQHRYVLECTHMAMEDGGITR--------KHISG--TKTGVYI---------------------------------------G-AMNDDY--KSLS-NL-----------D----H--D-EDTNYTATGMSTTIIASRVSYVYNLRGPC------MVVDTACSSSITAINLASEAIRSGDCDMAICGGVNSLLCP-DVFITLSRAKILSQTGQCQTFCDSAD--------------------------------------------------------------------GYARAEGCGIVIIKSLK-K--------------A--LQDKNKIWG-VVR-TGIN--QDGRSVQ-------P---ITTPSGEQHEELFKQVYSR-Y-DVNP-TDLQYIEAHG-----------------------------------------------------------------------T-GTRV------G------DPTEVNALG-RFIS-KY--RN-E--SKIANLKKDDDDDDDDAD----EINSPGQKGIVFKKRLNKEIKQNSHGTDNNAD-PYKE--R-----E-KILIGSVKTN-IGHAEAAAGMSGLIKVLLMMKNGSYVPSIH-IR-RDKSN--LNKNIK-LEEYGFDIAM--ETD-EWRT--N-E--L-GERICCVNSFG-FGGSNSHAIVIQIP----EH--R-S----K-----S-PN--TT-E-SN---L------------------------------------------W-------------------- 308 ------------------------IAVIGIGCRVP-G-A---ENVDEFWRVLV-NGENPI-IDVP-K--D-RW-NNDA--FYS----EDRDEAGKT-YVKKAGFI-----K-G--HD-EWDNKFFGVSDN-EAVSVDPQQRLVLDCTHMALEDAGITR--------QQLKG--SHTGVYI---------------------------------------G-VMNDDY--KSIS-SF-----------E----H--K-EDSSYSATGMSTSIISARVSYVYDLRGPC------MVIDTACSSSMMAIHLGSQAIKSGDCEMAVCGGVSLMLTP-DQFLTLCKAKMLSPTGQCQSFCDTAD--------------------------------------------------------------------GYARGEGCGIVIIKSYK-Q--------------A--LHDRNKIWG-IIK-TGSN--QDGHTAQ-------P---ITAPSGEQQEKLMKKVYSQ-Y-KLDP-TNLQYIEAHG-----------------------------------------------------------------------T-GTAI------G------DPTEVNAIG-KFIQ-SY--R---------QEQPQDKT----------DTDNNDENGI---------------P---SSN-KVNN--T-----V-PILIGSVKSN-IGHLESAAGVAALIKVLLMMKHGKFVPSLH-VK-KDKSN--VNRKII-FDEHGLDISL--QVS-EWNP--N-K--E-GDRICCVNCFG-FGGSNTHAVVIQKR----FP--I-Q----T-----I-QK--PY-D-NN---TE-------------------------NSYK-V----------I-------------------- 309 ------------------------------------------------------------------------------------------------------GFI-----K-G--HD-EWDNKFFGVSDN-EAVTVDPQQRLVLDCAHMALEDAGITR--------QQLKG--SQTGVYI---------------------------------------G-VMNDDY--KGMS-GF-----------E----H--K-EDSSYSATGMSTTIISARVSYVYDLHGPC------MVVDTACSSSMMAIHLGSQAIKSGDCEMAVCGGVSLMLTP-DQFMTLCKAKMLSPTGQCQSFCDTAD--------------------------------------------------------------------GYARGEGCGIVIIKSYK-Q--------------A--LHDRNKIWG-IIK-TGSN--QDGHTAQ-------P---ITAPSGEQQEKLMKKVYSQ-Y-NLDP-ISLQYIEAHG-----------------------------------------------------------------------T-GTSI------G------DPTEINAIG-KFIQ-SY--R---------QKQPHDKT----------DTDNNDENEI---------------P---LSN-KVSN--T-----S-TILIGSVKSN-IGHLESAAGIAALIKVLLMMKYGKFVPSLH-VE-KDKSN--VNRKMI-LDEHGLDISL--QVS-EWNP--N-K--Q-GDRICCVNCFG-FGGSNTHAVVIQKR----LP--I-Q----T-----I-QK--PY-D-NN---TE-------------------------NTYK-I----------I-------------------- 310 ------------------------VAIIGVGCRFP-G-A---DNISEFWRLLK-NGENHI-TDIP-L--Q-RF-NAEA--FCD----PDCTEDERT-SLTKAGLV------LT--YD-MWDNQLYGINDI-EGKRIESQQRFALDCTFMAFEEAGITL--------KMVNG--SNTGVFI---------------------------------------G-SMSTDC--KDSI-SH-----------D----A--E-DLTNYSTTSSASSIIASRVAYTFNLLGTA------MTLDCGYSSDMAAIHTASQALLAGDIDMAVCGGTNAILDP-TPFIAMYKSAQHGYG--------MTS--------------------------------------------------------------------ILTRGEGCGIILIKKLS-K--------------A--LADGNKIWG-ILE-TSCS--HTGSTPL-------S---FSSPSPCHMLPLWASAYTK-A-NVNP-QLVQYIETDG------------------------------------------------------------------------LLTQK----QDN------EQSELSAMQ-EFFC-NS--ED-R--QENRKEI----------------------------------------N----DD-SLGK--N-----F-KRKIGTAKHN-IGHLEAAAGMASLIKILLMMKYEEFVPTLV-GH-----D--VVS--L-AERFYFYVPT--TVQ-PWKE--N-S--A-GQRTASFNCFS-FSGTNFHVIVQQN------------------------------------------------------------------------------------------------------ 311 ------------------------IAIVGVGCRFP-G-G---DNLAEFWGVLV-NGENHV-KEIP-R--E-RW-NVDS--FYD----PDPKAPGKT-YVRRAGLL-----K-G--FD-EWDNKFFGISDA-EAELMDPQQRMVLDCVHMALEEAGITR--------PEVSG--SKTGVYI---------------------------------------G-VMNDDY--CSQV-MG-----------D----E--T-ISSSYAVTGTHRSVVSARVSYVYNLCGPA------LTIDTACSSSLVAMDVGSQALILGNCDMVICGGVNSLLDP-SVFIALSHARMLSPTGQCQTFSESAD--------------------------------------------------------------------GYARGEGCGIVVLKRLR-D--------------A--IKDGNKVWG-TIR-TATN--QDGHNAT-------P---ITAPSSEQQIALLDTIYKK-Y-HLDK-TRIDVIEAHG-----------------------------------------------------------------------T-GTAI------G------DPVESNALG-SFFS-KY--V-NT---------------------------------------------------------------A-----K-SIYIGSVKTN-IGHLEAAAGVAGLIKVLLMMKNKVIVPTLM-YN-KE--R--ENKKLH-LHHHHLSVPT--EVI-PWDI--N-F--G-KERLACVNSFG-FGGTNAHAVVQEYN----MK--D------K------------------------------------------------------------------------------------R 312 ------------------------MAIIGIGCRFP-G-A---DDIDAFWRLLR-NGENHV-LEIP-R--D-RF-NISA--FYD----EDKDKIGKT-YNKTAGLV-----Q-E--YD-MVDGPLYGINES-EAAKMDPQQSFVLDCTHMALEDAGIPP--------SSLRG--SKTGVYI---------------------------------------G-CMNDDF--KCDA-VM-----------D----V--T-NISTYSQTGNTGSAIASRVAYAFNLLGPA------MIVDTACSAALVALHTAARAISAGDVDMAICGGVNVIMHP-HAYVALSRAKMAGATGQCQAFSDNAD--------------------------------------------------------------------GYARGEGCGIIIIKKYA-QAKV----------------DGNKIWA-KIM-TGCN--QDGRTVT-------P---MTAPSGYQQTVLLKNIYKH-C-GVDP-MSIQYIEAHG-----------------------------------------------------------------------T-GTPI------G------DPTEINALG-YFFS-SP--ER-D--DGK-DEE----------------------------------------------------PII-----D-KIKIGSVKSN-IGHLESAAGAASVIKMVLMMKHGEFVPSLM-CE-----P--ANKKIL-FDLFRIEISK--EVC-VWKA--N-S--T-GQRLGCINCFG-FGGTNSHAIVIQDK----ID--P------V-P---C-QG--DL-H--G---T--E-YV-FV-------Q-S------AENEASLRT----------------------------- 313 ------------------------IAIVGVGCRFP-G-A---DSLAEFWKVLV-NGENHV-KEIP-K--E-RW-NVNT--FYD----PDPKTPGKT-YVRHAGLI-----N-R--FA-EWDNKFFGISDA-EAELMDPQQRMVLDCVHMAMEDAGLTR--------PEVSG--SNTGVYI---------------------------------------G-VMNDDY--SNQI-MS-----------D----K--T-VTSSYALTGTHRSIVSARVSYVYNLLGPA------LTIDTACSSSLVAIDLGCQALTLGNISCAFCGGVNAILNP-SLFISLSKARMLSPTGQCHTYSADAD--------------------------------------------------------------------GYARGEGCGIVVLKRLK-D--------------A--IKDGNKIWA-TIR-TATN--QDGHNAT-------P---ITAPSGEQQYLLLDTIYQK-Y-QVDP-SRIDVIEAHG-----------------------------------------------------------------------T-GTPI------G------DRVETNALG-RFFS-KN--S-TS---------------------------------------------------------------A-----K-TVHIGSVKPS-IGHLESAAGVAGLIKVLLMMENKTIVPSLM-YS-KE--N--ENKQLN-LKQYFLNVPT--ERF-PWDT--H-L--G-AKKLACINSFG-FGGTNAHVIVEEYF----QS--T------K-S---I-G------------------NS-DS-------W-L------PNIVVVSADDQDSLE----------------------E 314 ------------------------MAIVGIGCRFP-G-A---DDIYEFWRLLR-NGENHV-LEIP-R--D-RF-NVSA--HYD----PDKDKVGKT-YNKTAGLV-----R-D--FN-MIDNQLYCIDDN-EAAKMDPQQNFVLDCTHMALEDAGILP--------SSLRG--SKTGVYL---------------------------------------G-CMNTDY--KADL-VM-----------D----T--N-DISNYSQTGSTGSSIASRVAYTYNLHGPA------MIVDTACSSALVALHTAARAICAGDVDMAICGGVNAIMDP-TAFVALSRAKMAGATGQCQAFSENAD--------------------------------------------------------------------GYARGEGCGIIIIKKYS-KALI----------------DGNKIWA-RIL-TGCN--QDGRTVT-------P---MTAPSGAQQMALLKHVYEQ-S-RVDP-MSIQYIEAHG-----------------------------------------------------------------------T-GTPI------G------DPAEVNTLG-MFFS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 315 ------------------------MAVIGIGCRFP-G-A---DDIDEFWRLLR-NGENHV-FEVS-R--D-RF-NVSA--YYD----PDKDKAGKT-YSKTAGLV-----K-D--YN-MIDNQVYGIDES-DAARMDPQQSFVLDCTHMALEDAGIPP--------SSLRG--SKTGVYI---------------------------------------G-CMNTDY--KDDI-IK-----------D----T--T-DISNNSQTGCAGSSIASRVAYIYNLQGPA------LIVDTACSSALVALHTAARAICAGDVDMAICGGVNAIMGP-TAFVALSRAKMAGATGQCQAFSDNAD--------------------------------------------------------------------GYARGEGCGIIIIKKYS-KALL----------------DGNKIWA-RIL-TGCN--QDGQTVT-------P---MTAPSGAQQMALMKHVYEQ-S-RVDP-MSIQYIEAHG-----------------------------------------------------------------------T-GTPI------G------DPVEVNTLG-LFFS-MQ--IN-G--EKR-GDR---------------------------------------------------APVI-----D-KVKIGSVKSN-IGHLESAAGVASVIKMVLMMKHGEFVPSLM-SE-----P--ANKKIQ-FDRFRIEVSK--EVC-EWKT--N-S--S-NQRLGSINCFG-FGGTNSHAIVIQEN----DH--Q------V-L---C-HR--NK-E--G---T--K-YI-FA-------H-S------AENVVSLKA----------------------------- 316 ------------------------VVISGTSCRLP-Q-S--E-NMQEFRDNLI-SGVDMV-TE---DDS--RW-QPGL--------------F--G-LPTRSGKLK--------DLSK-FDAAYFGVHPK-QANRMDPQLRMLLEVTYEAIIDAGVNP--------ETLKGT--RTGVFI---------------------------------------G-ASASES--HDAW-SC---D------------P--E-STVGYTMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------YSIDTACSSSLLALDQALHSIRSGQCDAAIVGGSNLCLKPTIALQFMKLGMLSPD-GMCKSFDAEGNGYCRSEGIVAMYLQRRP-E--------------A--KR----VYC-TVIHSRTN--SDGNKQQ-------G---ITFPSGEIQKRLLQEVYSE-A-CIDP-SRVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIC-EVFC-K--D---R----------------------------------------------------------------Q----G-PLPIGSVKSN-MGHSEPASGLAAVAKVIVAMEEKVIPGNLH-F---E--T--PNTDIPGLVNGQLQVVD--HNT-RWNG-----------GLVGVNSFG-FGGSNVHTVLKSN----SKS---------K-A----ISA--GC-K-------------------------D------KRLFLYASRSEEGLKDI--L------------------ 317 ------------------------IAVVGMGGRFP-G-A---DNIDEFWRVLV-NGENHV-VDIP-P--E-RW-NNDA--FYS----ENKDQPGKH-YVKKAGFL-----K-N--YD-YWDNKVFGISDG-EAERIDPQQRYVLECTHMAMEDGGITK--------KQLSE--VSTGVYI---------------------------------------G-VMNDDY--KELS-ST-----------Q----H--D-DDTNYSATGMSTTIIASRVSYVYNLTGPC------MVIDTACSSSMVAIHLGCQAIRAGECKMAVCGGVSSILSP-DTFIFLCKARMLSPTGQCQAFCDTAD--------------------------------------------------------------------GYARAEGCGIVILKSYK-Q--------------A--IQEKNKIWG-IVR-TGSN--QDGRAAQ-------P---ITAPSAEQHEKLFRNIYTC-F-NVDP-NSLQYVEAHG-----------------------------------------------------------------------T-GTAV------G------DPTEMHALG-NFIV-SH--GK-F--ANCARHQKAPVPTEDSNL----HDPTLNIIQGKTIHST--HNEKIKPSSQ--LK-VTFS--K-----E-KILVGSVKTN-IGHTESAAGVAGLMKVLLMMANGKIVPSLH-LK-KDKSS--LNPKIN-LDDFGLDIAL--DVC-EWKP--N-R--Q-GERIGCVNSFG-FGGSNSHAIVIQ----------------------------------------------------------------------------------K-------------------- 318 -------------------------------------------------------------------------------------------------------------------IS-GFDNEFWAIPGV-EAEKMDPQQRLILECTHMAFEDGGFSR--------KDLDG--SKTGVYI---------------------------------------G-SMMDDF--RSLN-AT---------------AH--D-DVTHYSLTGTSRNIIPNRVSYTYNLLGQS------LTVDTACSSGLIAVDLAINAMKRGSIDLAVCGGVNVIQLP-YPFIALCETKMLSKTGKCHAFSADAD--------------------------------------------------------------------GYARGEGCGVVILKKLK-QA----------------NLDGDKIWG-IIA-TASN--QDGRMAT-------P---ITAPSGEQQRQLLDMVYPA-A-GVDP-AEIQYVEAHG-----------------------------------------------------------------------T-GTPT------G------DPIEYNCLG-RFFT-QA--QE-IKGR------------------------------------------------------------R-----F-RLPVGSVKTN-VGHGEAVAGITSLIKVLIMMKEGEIVPSLH-FS-KD--N--ANPKLN-IEQYCLDVVT--QNE-KWEA--N-K--D-GERLACVNAFG-FGGSNCHAIVKQPK----QQ--G-L------Q---P-RT--RN-A-SQ----------------------D------NVIVTFSAKSGESL---M------------R------- 319 ------------------------LVVCGLSGRYP-D-S---ANVGELTHNLF-NGINMI-TV---DDR--RW-PPG-------------Y-F--G-TPEVMGKLR--------NITD-FDAEFFGVHSK-SANTMDPMMRILLEVVYETIVDAGESL--------ESMKGS--KTGVYI---------------------------------------G-VSVSEC--EVAW-MK---E------------W--S-EDNAYMVQGCPHSMFPNWVSFFFDLRGP--------------------------------------------------------------------------STAYNTACSSSLVCLDAAERHLRMGIIDNAIIGGCNILYRPSTSRLFMTMNFLGTT--ACRAFDETGDGFVRAEVVSAMLIKKAS-S--------------A--KR----VYG-TLVGSMLN--NDGFQLN-------G---ILYPNTLAQEQLMTDIYPA-L-NVDP-KEVKYFECHG-----------------------------------------------------------------------T-GTQA------------GDPNETRAIC-NAVC-K--G---K----------------------------------------------------------------K----D-PLLIGSVKTN-LGHGETASGMAGLSKVMVILHSRKIPPNLH-F---N--T--PNPKIPGLFDGRLKVVT--ETT-PFD-----------GGLIAINSFG-MGGTNAHAIFRSF--D--KR--A--------E----PHP--AS-D-------------------------K------PRLFTYCARTEEGLQKIF-------------------- 320 -------------------------CIAGVGLRLP-K-A---NNLDELADLLQ-KGETSF-E--E-T----RW-QHG---LFG--------------MDHTCGRVE------P--IG-EMDCEFFNISP-TEAYSSTHMLGPLLEVVAESILDSGLTF--------DMVSRL--TTGFYL---------------------------------------G-MTLCDT--DGL-HA---------------------GE-----ATFNQGSELSASVAQRFDLHGPV------QHVDGACASSFVALHAALLDLHTGRCDLAIVAGSNLVQDP-MASLQFAKMNMVSPQGKSLPFDERAD--------------------------------------------------------------------GYVRSDGIVAYLLKLSD-S---------------LPSR----EYCD-IVAFELQ--NNGKRKQ-------G---ITNPNHKFQSKLLGDVYA----NIDV-NDLAYFEAHG-----------------------------------------------------------------------T-STQK------G------DKAELTAIE-STLC-CI--R------------------------------------------------------------------Q-----N-PLVVGSLKGN-FGHTEATAGLAGIAKCLAMYKKETIFRMPN-FK-----T--PNPTIEALKNGSIIIPT--SNI-PLSK----D----PGALLGVSTYG-FGGLGGHAVLRRS------------------------------------------------------------------------------------------------------ 321 ------------------------VSISGISGRMP-E-S--G-NMQEFRDHLM-KKENMV-TA---DNR--RW-EV-------------GM-H--G-LPPKNGKLN--------EITK-FDAGFFGVHPK-QADCMDPQLRMLLEVAYEAVVDSGQSL--------QSVRGS--RTGVFI---------------------------------------G-VSMSEA--GDAW-SA---D------------P--E-TLVGYSMPGCCRAMFANRISFFFDFKGP------S--------------------------------------------------------------------YTIDTACSSSMMGLDQALQNIRMGIIDAAIVGGTNLCLKPQTSLQFTRMTMTSPD-GHCKTFDASGDGYCRSEAVMAIYLQKSQ-D--------------C--KR----IYM-SVVHTKSN--SDGHKVE-------G---ITFPSGILQKSLIEDVYHE-I-GLNP-KDIDYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNTIV-DVFC-K--D---R----------------------------------------------------------------T----T-PLLIGSTKSN-MGHPEAASGITSIAKIIIAMEERTIPPNLH-Y---N--T--PNPEIPGLSDGSLKVIT--ECT-RWGG-----------GLVSMNSFG-FGGSNVHAIYKSH--D--KE--L-T------N----LHP--AA-D-------------------------K------PRLFTFGARSEEGVRQVL-------------------- 322 ------------------------IAIVGVGCRFP-G-A---DDLFGFWRVLA-NGENHV-TEVP-A--D-RW-NVDH--FYD----PDENAPGKM-YVKNAGFI-----H-G--VE-EWDRAFFGISEQ-EGIRMDPQQRLVLQCVHMATEDGGFTR--------KDLAA--VKTGVLI---------------------------------------G-CMTQDY--GSQA-NE-----------DA------C-TTGPYSVTGIHSSILSARVSYVYNLTGPA------LTVDTACSSSLVAIHFGAQALLSGDVDIMICGGVNCLLEP-NLFVALCKANMLARDGQCKAFTKDAD--------------------------------------------------------------------GYGRGEGCGIVILKRLK-D--------------A--VHDGNKVWG-LIN-TGTN--QDGQYAN-------P---ISAPSSKQQEQLIQDVLRK-Y-NIDP-DNITVIEAHG-----------------------------------------------------------------------T-GTKI------G------DPTECLALG-HALG-SD--T------K-------------------------------------------------------------------TKFLGSVKTN-IGHPEAAAGVAGLIKILLMMKHKKIVPSLW-YT-PE--N--ENLNLQ-LSKNGFVVPT--QLQ-DWHN--G-Q--N-KTRMASVNSFG-FAGTNAHAVIYENI----ER--N------S------------------------------------------------------------------------------------E 323 ------------------------VVISGVSCRLP-Q-S--A-NMEEFTDNLM-NGVDMV-TE---DDS--RW-TPGL--------------Y--G-LPRRSGKLK--------DLSK-FDAAFFGVHPK-QANSMDPQLRLLLEVTYEAIVDAGVNP--------DTVRGS--RTGVFI---------------------------------------G-ASASES--HEAW-SA---D------------P--E-AAPGYSMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------YTVDTACSSSLLALDQALHSIRTGLCEAAIVGGSNLCLKPAVAAQFMKLGMLSPD-GMCKSFDAQGNGYCRSEGVIAMYLQKEP-V--------------A--RR----IYC-TLVHSKTN--SDGNKEQ-------G---ITFPSGAVQKQLLEEVYSE-A-GLSP-ALVSYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIC-DIFC-K--G---R----------------------------------------------------------------T----E-PLPIGSVKSN-MGHSEPASGLAAVAKVIVAMEEGCIPGNLH-F---H--E--QNPDIPGLADGRLKVVD--RNT-TWRG-----------GLVGVNSFG-FGGSNVHAVLKSN----NTS--E------K-T----LCR--NC-E-------------------------K------KRLFVHSSRSEDGLKKA--L------------------ 324 ------------------------VVITGISCRLP-E-S--D-NMDEFRQHLM-LKEDMV-TD---DDR--RW-PTGF--------------L--G-IPDRNGKIK--------DISK-FDASFFGVHPK-QANAMDPQLRLLLEVAYEAIVDSGYSP--------QSLRGS--RTGVFI---------------------------------------G-ASASEA--SEAF-SS---D------------A--E-KMDGYGMIGCCRAMFANRLSFFFDLKGP------S--------------------------------------------------------------------YAIDTACSSSSLAMDQALASIRMGICDAAIIGGTNICVKPNTALQFLKLGMLSPD-GCCKSFDANGNGYCRSEGIIAIHIQKAS-A--------------A--RR----IYS-TVVHSKNN--ADGNKEQ-------G---ITFPSGAAQKKLLEETYHE-A-GVDP-SQVAYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNSIV-DVFC-K--D---R----------------------------------------------------------------N----E-PLLIGSTKSN-MGHPEPASGLASLAKVIIAMEEKILPANLH-Y---N--E--PNPNIPGLVDGRLKVVT--EGT-RWSG-----------GYVGVNSFG-FGGANVHLILKSN----DSE--K-S------E----QHP--AS-S-------------------------S------RRLCVYAGRTEECVDHVL-------------------- 325 ------------------------IAIVGIGCMFP-G-A---ENLEEFWKVLV-NGEDHV-QDIP-L--E-RF-NVEA--YYD----PDPDHPYKS-YIRKAGLL-----R-K--YD-EWDNRFFGISDK-EAESVDPQQHFVLESVHMALEDAGIPK--------EKIAG--SGTGVFI---------------------------------------G-ALNHDL--DCVL-RT-----------A----R--Q-KTTNTTVTGTDSSLLSARIAYFYNLLGPA------ITLNSACSSSMTAIHIASQALRNGEISMAITGGVNCILDP-ASFITLSSARMASPTGKCHTFSENAD--------------------------------------------------------------------GYARGEGCGIVILKTLK-D--------------A--LRDKNKIWG-TIF-TGLN--QDGHTVS-------P---ITSPSGKQQEQLLEYVFEK-H-KILP-RNVQYIEAHG-----------------------------------------------------------------------T-GTTV------G------DFTEVSALG-RFFS-KY--A------------------------------------------------------------------L-----H-EIPIGSVKTN-IGHIEPGAGVASLIKVLLMMKNKTFVKSLH-AE-P------LNSKIP-FKEFKLKVCQ--KVS-SWKP--N-E--N-GNRVASINCFG-FGGTNAHAIVHDFQ----T-----------------------------------------------------------------------------------------------Q 326 ------------------------IVISGISCRLP-E-S--D-NMQEFREHLI-LGEDMV-TK---DSR--RW-EPGY--------------L--G-LPPRNGKLK--------DISK-FDAQFFGVHPK-QADSMDPQLRILLEVTYEAIVDSGLNP--------QSVKGT--NTGVFI---------------------------------------G-VSSSEA--GEAW-SA---D------------P--E-KVVGYSMTGCCRAMFPNRLSYFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLLALDQALMSIRLGKCDAAIVGGSNLCLKPTTALQFLKLGMLSPD-GACKSFDASGNGYCRSEAIVAIFIQKAS-A--------------A--KR----VYS-TIVHSKNN--SDGAKEQ-------G---ITFPSGEIQKRLLKDVYMD-A-GLSP-LVVSYVEAHG-----------------------------------------------------------------------T-GTAV------------GDPQEVNSIV-DVFC-K--D---R----------------------------------------------------------------K----S-PLLIGSVKSN-IGHPEPASGLASVAKVIIAMEDGMVPPNLH-F---N--T--PNPDIPGFQDGRLKVVT--ENT-PWNG-----------GHVGVNSFG-FGGANVHTILKSN----SKK--R-T-----------VHG--AA-D-------------------------S------ERLFVYSSRTEEGLKTVF-------------------- 327 ------------------------IVISGIAARLP-Q-S--E-TMEEFKTNLL-GGFDMV-TE---DES--RW-TPGL--------------H--G-LPTRSGKLK--------NLWK-FDATFFGVHPK-QANTMDPQLRLLLEVTYEAILDAGVNP--------ESVRGS--NTGVFI---------------------------------------G-ASASES--ADAW-SM---E------------P--E-STVGYVMTGCTRSMFSNRLSYFFDFKGP------S--------------------------------------------------------------------YTIDTACSSSLLAMDQALLSIRSGQCDAAIVGGASLCLKPAVAVQFMKLGMLSPD-GMCKSFDSEGNGYCRSEGIVAIYLQKEP-T--------------A--KR----IYC-TLVHSKTN--SDGNKHQ-------G---ITFPSGEVQKRLLKEVYSE-A-CIDT-STVSYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNSIC-DVFC-K--D---R----------------------------------------------------------------K----E-PLSIGSVKSN-MGHAEPASGLAAIAKVIIAMEGGIIPANLH-Y---N--S--PNVDIPGLTDGSLHVVG--QNK-EWDG-----------GLVGVNSFG-FGGSNVHAVLRSN----KTT--N--------I----STE--AC-D-------------------------N------KRLLVYCSRTEDGLKETL-------------------- 328 ------------------------VVITGISCRLP-E-S--D-NMTEFRQHLM-LKEDMI-TD---DDR--RW-QPGF--------------L--G-LPQRNGKLK--------DLSK-FDASFFGVHPK-QADAMDPQLRLLLEVAYEAIIDSGYSP--------QSLRGS--KTGVFI---------------------------------------G-VSASEA--GEAL-SA---D------------P--E-TLVGYGMTGCCRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSSLAMDQALASIRAGICDAAIVGGSNICIKPNTALQFLKLGMLSAD-GCCKSFDANGDGYCRSEGIVAIHIQKVS-A--------------A--HR----VYT-TIVHSKNN--ADGNKEQ-------G---ITFPSGAVQKQLLEETYHE-A-GVDP-SQVAYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNSIV-DVFC-K--D---R----------------------------------------------------------------N----E-PLLIGSTKSN-MGHPEPASGLAALAKVVIAMEEKIVPANLH-Y---E--E--PNPDIPGLVDGRLKVVT--EGT-RWPG-----------GYVGLNSFG-FGGANVHLILKSN----DNE--K-S------E----QHP--AT-S-------------------------C------RRLCVYAGRTEECVDHVL-------------------- 329 ------------------------IAVLGAGFKGP-G-A---DNLEELWRVLE-RCENHI-VDIP-K--E-RW-NNDA--FYD----PNPQAASKS-YVRKGGFM-----K-K--PF-AFDNSLFNINDM-ESDQMDPQQKHALECTYRALEHAGLTR--------HQVRG--TNTGVYI---------------------------------------G-AMNSDY--RSLY-QV-----------G----S--S-GVNNYTVTGVSNSIIAARIAFSFDLRGPT------MVIDTGCSSALIAIHTASQALKTGDCDLAICGGTNFMLSP-DVFVHLSKAQMVSPSGQCYAFSDKAD--------------------------------------------------------------------GYTRGEGCGIVILKRLA-D--------------A--QRDGDRVLA-TIE-TGTN--QDGHSVT-------P---ISAPSQKQQLDLLVNTYRH-M-TNQELEELDYIEAHG-----------------------------------------------------------------------T-GTTL------G------DPTEAKALG-EFFK-LR---G----S------------------------------------------------------------K-----K-RRLIGSIKSN-IGHLESGAGVVGLIKVLLMMEHSKIVPSLF-SE-----T--PSTKID-FENLNLTLAS--KVI-DWKK--E-------RHLACVNSFG-FGGSNCHVIVKSQR----KK--P-E------Q---K-C-----------------------WE-----A-K------PAIICFSGKNEESL---K-------------------- 330 ------------------------VVVTGISCRLP-E-S--D-NMEEFRQHLI-LGDDMV-TA---DNR--RW-EPGL--------------H--G-LPARNGKLK--------DLSK-FDATFFGVHPK-QADAMDPQLRMLLEITQEAIIDAGVNP--------LSVRGS--RTGVFI---------------------------------------G-VSSSDA--GEAW-SA---D------------P--D-KLVGYSMTGCCRAMFANRLSYFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSMLALDEALHSMRMGHCDAAIVGGSNLCLKPMSALQFLKLGMLSPE-GSCKSFDESGNGYCRSEGIVAIFLQKRS-V--------------A--RK----ILS-TVVHSKTN--SDGCKEQ-------G---ITFPSGAVQKQLLTEVYEE-C-GVPP-SEIAFVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNSIA-EVFC-H--G---R----------------------------------------------------------------K----E-PLLIGSIKSN-MGHPEPASGLAAVAKVIIAMEDGMIPANLH-F---N--N--PNPDIPGLFDGRLKVVT--ERT-RWNG-----------GYVGVNSFG-FGGANVHVVLQSN----NVE--K-T------L----VHV--AS-K-------------------------A------RRLLTYSSRTEEGLKHLF-------------------- 331 ------------------------VAIIGVGCRFP-G-V---NNLDEFWNVLK-QDEDHM----P-E--N-KR-NA---------------------------E-------S---HA-EWDYRIYGINED-QSLEMNSQQQSVLNSTYMALENAGITN--------QQLNS--SNTGVYI---------------------------------------G-MVNTGC--SSNN-SY-----------C----S--Q-VLDKHKIASNQKQSVAWMLSNIFNLHGPS------ITVDAWSFPSLMAIQQAHQAILSRKCDIAISGGVTALND---------------------------D--------------------------------------------------------------------RCSRGEGCGIIILKSLQ-K--------------A--LEDNDPLWG-TIS-TSSD--HGSHINA-------P---NTRPLLDQQLEVLDLFFKR-H-NIEV-KTIDYIEAQS------------------------------------------------------------------------TDMDA------Y------DAVEVTALM-TFFQ-KI---G-K-----------------------------------------------------------------------TRIIGSVETN-KKQLECTVGLAGLIKILLMHKYQKIVPSPW-FE-----K--ASEYVT-LNKSTFMVPE--KTT-NWPD--N-D--K-GYLRSYLNSFCHFCRFNCHVVVTT------------------------------------------------------------------------------------------------------- 332 --------------------------IGGMSGKFPQ--S---ENLQEFWENLE-SGKDMI-G-------PTRW-PKG---LYN--------------LPPRTGCFK------N--LHQ-FDAEFFELMDLEECEESNELLRFLLEVIYECLVDSGLKL--------KTFQSE--RTGCYI---------------------------------------A-YSFSDT--DAI-QT---------------------SLD-IEASKINSGPSILSSVVRHFGLTGPA------ITIDTACSSSLSVLNRAVRDLSQKQCRYAIVAGTSIIDNP-NASLRFLRLNMLSPNGTSNVFDKSAN--------------------------------------------------------------------GYVRADGMAAILLARND-E---------------DLAR----VYAS-IVNVGVN--CDGYKVE-------G---ITYPSSKSQANLLTSLYH----DIST-NQIAYVEAHG-----------------------------------------------------------------------T-GTQA------G------DKNEAQSLG-TVLS-EG--R------------------------------------------------------------------S-----S-PLLVGSVKSN-MGHGEAVAGLAGIIKCLLSIHHGRIPGNLN-YR-----I--PNPEIPQLRNGQIKVVD--KTI-DLPD----G-------LIGVNSFG-FGGVNGHVVLEPYK----KK--H-G------C---K-KD--H----H------------------------------VSIVTFTARTKSVMEDVL-------------------- 333 ------------------------IVVVGIGCRTP-G-A---DNTQEFWELLK-RGECMI-TDVP-P--D-RW-NAAA--YLDT--DSSTGAFGKA-YVQKGGFV-----K-D--IY-GFDNALYDIKEF-EAIQMDPQQRMLLDCTYMAMQDAGINR--------TDIWQ--TNTGVFV---------------------------------------G-CMNNDH--ATSY-LA-----------S----T--S-KTSSVSTTGCDMSVLPGRLSYVFNLLGPS------MMIDTACSSSLIALHLACQAIRAGDCDMAICGGVNCMILP-EMYVQLCKAGMLSPTGLCHTFSDQAD--------------------------------------------------------------------GYIRGEGCGVVILKWLK-D--------------A--LRDGNNILA-TVVGTCNN--QDGRTATSDGGRTAP---LSAPSGSQQVKLLTSVYRK-A-GVDV-TRLDYIEAHG-----------------------------------------------------------------------T-GTAT------G------DPVEVNALR-EFLR-TE---G----G------------------------------------------------------------P-----R-DRYIGSLKTN-IGHTESAAGILSVIKLVLMMKHNMIVPSLH-C---H--V--VNPRIN-LTDCRFIIPK--QAV-PWPN--K-------EKLAGCSGYG-VGGSNCHVALASYS----PS--N-P----------T------E-A-R-------------ATR-----R-T------SYVVCFSAKTERSLK--A-------------------- 334 ------------------------IAIVGMGCRTP-G-A---DNIQEFWRLVA-NGECHI-TDVP-Q--E-RW-NAEA--FYS----EDPTAPGKA-YVQRGGFI-----G-D--LE-GFDNSLYGIGNL-EASGMDPQQTLLLDCTTMALQDAGITR--------QQLFG--SNTGVYI---------------------------------------G-TMNSDH--RAGA-LA-----------M----N--S-KVGTYTATSRATTLLANRISYVFNLLGPS------ITIDSACSAALISIHLARQAILTGDCDQAICGGVNCMLLA-DVFVHLSKSRIISPTGLCHTFSDKAD--------------------------------------------------------------------GYVRSEGCGVVILKRHS-D--------------A--LRDGDHIWA-TIC-TGTN--HNGHSVT-------P---VTSPSGEQQKQLLQSVYSR-F-PVDL-SRLDYIETHG-----------------------------------------------------------------------T-GTPL------G------DVVEVNALG-SFLK-EK---G----Q------------------------------------------------------------Q-----R-QRYIGSVKTN-IGHTESAAGILSVIKLCLMMKYDTIVPSLH-C---E--V--VHPGID-LKDLNFDIPK--TSV-PWPS--P-------DKLTCCNSFG-FGGSNCHAILQSVR----KA--T-E----------G------T-H---------------KIG-------G------SCIVCFSGRSAKSLKGSL-------------------- 335 ------------------------MAIIGLGCKVP-G-A---DNLEEFWRLLE-NGENHV-IEIP-T--T-RW-HHEA--VYD----EDFNTPAKT-HARKAGLL-----K-D--HL-AFDNKLFNIKDV-EADIMDPQQRYVLECCHRALEDAGITR--------DQIKG--SNTSVFI---------------------------------------G-AMNTDY--RSEF-NS-----------T----S--F-VPDNYAVTGVASSIIANRVSFVYDLRGTS------VTIDTACSSSLVAIDLGIQALRAGACDMVICGGTNSILTP-DVFIHLSKARMVSPKGQCFAFSDQVD--------------------------------------------------------------------GYTRGEGCGVVILKRLH-D--------------A--LEHKNKIWA-TIE-TGCN--QDGGTVT-------P---MSKPSEEQQTKLLQEVWSK-S-QADP-SLLTYIEAHG-----------------------------------------------------------------------T-GTPV------G------DVVEVKSLG-TFLK-RN--Q-----V------------------------------------------------------------E-----RS-RYIGSVKTN-IGHLESAAGVAGLIKVLLMMKHSKIVPSLH-FQ-RP------NPAID-FSGYQLKVPT--VLT-DWPD--V-------HKVASVSSFG-FGGTNCYAIIESHE----QL--E-S------T---K-S----D-V-N--------------------C--------------------------H-------------------- 336 ------------------------VVISGISCRLP-E-S--E-NMEEFRQHLI-LGEDMV-TA---DDR--RW-EPGL--------------H--G-LPTRNGKLK--------DISK-FDATFFGVHPK-QADAMDPQLRMLLEATQETLVDAGVNP--------TSVRGS--RTGVFI---------------------------------------G-VSSSDA--GEAW-AA---D------------P--E-KLVGYSMTGCCRAMFANRLSYFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLLALDQALHNIRMGHCDSAIVGGSNLCLKPTSALQFLKLGMLSPE-GSCKSFDESGNGYCRSEGIVVIYLQKRS-A--------------A--HR----VLS-TLVHSKSN--SDGNKEQ-------G---ITFPSGAVQKQLLTDVYHE-A-GLSP-SKVSFVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNSIT-DVFC-K--D---R----------------------------------------------------------------K----E-PLLIGSTKSN-MGHPEPASGLAAVAKVIVAMEDGMIPANLH-Y---K--N--PNPDIPGLWDGRLKVVT--ERT-RWNG-----------GYVGVNSFG-FGGANVHSVLKSN----NIE--K-T------R----VHP--AS-K-------------------------A------KRLLTYSSRTEEGLKHIF-------------------- 337 -------------------------------------------------------------------------------------------------------------------MG-MMDCDFFNIPP-EEAVMCNPMLGPLLEVVAESILDSGLKL--------SDVSKH--CTGFYL---------------------------------------G-ATFCDT--DVM-VS---------------------N-LETSSNSFNTRTELSARVSHHFDLKGPV------IQFDGACASSFAALHAAMLDIQANRCEIAIVAGANLVLDP-MVSVQFSKLNMLSPTGLSAPFDESAN--------------------------------------------------------------------GYVRTDGIVAILLKSDA-S--------------HISSR----TYCS-VVGFGLK--SQGANGK-------G---ILRPSKHFQSELLEEVYE-K-FNINV-EDVVFLEAHG-----------------------------------------------------------------------T-STQI------G------DKTELGAIN-KALC-SK--R------------------------------------------------------------------T-----K-PIIVGSIKGN-IGHTEACSGLAGILKCLASYRTNTIFSNVN-YK-----T--PNSAIPALHTGDIIVPV--TSV-PLPQ----G----GANLMCVSCFG-FGGLGGHIVLKP------------------------------------------------------------------------------------------------------- 338 ------------------------VSISGISGRLP-E-S--D-NMAEFREHLM-NKEDMV-TA---DDR--RW-KM-------------GL-H--G-NPPRNGKLK--------EIRH-FDAGFFGVHPK-QADCMDPQLRMLLETAYEAIIDSGQTL--------ESVRGS--RTGVFV---------------------------------------G-VSMSEA--SDAW-TS---D------------A--E-STVGYTMPGCCRAMFANRISFFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALMNIRMGIIDSAIVGGTNLCLKPNTSLQFVRMGMTSPD-GACKTFDASGDGYCRSEAIMSIFLQKSA-D--------------C--RR----IYA-TVVHSKTN--SDGYKEQ-------G---ITFPSGILQKQLINEVYHE-I-GINP-SDIAYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQETNSIV-EVFC-K--G---R----------------------------------------------------------------K----D-PLLIGSTKTN-MGHPEAASGLSSIAKIIIAMEERVIPPNLH-F---K--T--PNPDIAGLLDGRLKVVT--ECT-RWNG-----------GLVAMNSFG-FGGSNVHAVYRSH--D--KE--L-T------E----PHI--AS-D-------------------------K------PRLFTCSARTEAGVKALL-------------------- 339 ------------------------IAIVGIGCRTP-G-A---DNIRDFWRVLQ-NGECHI-TEVP-A--D-RW-NAAA--FLD----SDPLAPGKT-YVQKGGFI-----K-D--VE-GFDNGLHGINDY-EARQMDPQQCLLLECTTMALQDAGITR--------NHLSN--SNTGVYV---------------------------------------G-SMNNDY--GSKF-IG-----------K----T--T-KVDNYTATGISNTILASRLSYTFNLTGPC------MVLDTACSASLVAVHQGCLAIRSGDCDMAICGGVNCMLTP-DMFVTLSKARMISPSGLCHTFSDQAD--------------------------------------------------------------------GYTRGEGCGVVILKRLK-D--------------A--IRDGDNIRA-IVY-TGTN--QDGHAVT-------P---MTAPSGEQQKKLLHSVYNK-Y-RINV-TEVDYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPVEVSSFG-SFFK-ES---G----P------------------------------------------------------------P-----R-ERHIGSVKTN-IGHTESAAGVLGLIKVLLMMEHDMIVPSLH-C---Q--V--ANPKID-LPGHGFVIPQ--DPI-PWNK--P-------NKVAACNSFG-FGGSNSHAVVRSYT----GN--G-S----------R------Q-S---------------AQE-----K-G------RCIVCFSGKTQKALKNSL-------------------- 340 ---------------------------------------------------------------------------------------------------QKGGFI-----A-N--VD-SFDNVLYGINDY-EATQMDPQQFLLLDCTTMALEDGGLTR--------QQLSG--SSTGVFI---------------------------------------G-AMNNDY--AISY-NG-----------H----T--S-KVNTYTGTGASTAILASRVSYVFDLRGPC------MVVDTACSASLVAVHQACLAIRSGDCDMAICGGVSCMLNP-NMHLKLCKARMISPTGLCHTFSEDAD--------------------------------------------------------------------GYARGEGCGIVILKRMK-D--------------A--RRDGNKVWA-TIN-SGTN--QDGRCVT-------P---MTAPSGEQQKKLLHAIYNK-H-QVDI-SRLDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEVNALG-SFLK-ER---G-G--P------------------------------------------------------------P-----R-SRYIGSVKTN-IGHTESAAGVLSMIKVMLMMKHNTIVPSLH-C---Q--K--VNPKID-LQSWQFIIPT--QLV-PWDN--P-------SKMAACNSFG-FGGSNAHVVISSLP----------------------------------------------------------------------------------------------------- 341 ------------------------IVVVGLGCRTP-G-A---DNQWEFWRLLE-NKECHV-GDVP-S--D-RW-NTLA--YSDSGNIKRTDGMDRP-FVQKGGFL-----K-D--VW-SFDNLLYRISDY-EAAQLDPQQSILLECTTMAMEDAGITR--------RDLAG--SRTGVYI---------------------------------------G-AVHHDY--ATTF-VG-----------Q----V--S-TVDQYTVSGITNTIMASRLSYEFDLRGPC------MVLDTACSVSMVAIHQSCLAIRSGDCDMAICGGVNCMLTP-HIFMLLSEARMISPTGQCHAFSKDAD--------------------------------------------------------------------GYARAEGCGVLILKRLK-D--------------A--IRDGNQIYA-TVY-TGTN--QDGRTVT-------P---MLQPSGQQQLSLLRDVYSR-H-GIDV-TGIQYFEAHG-----------------------------------------------------------------------T-GTPV------G------DPVEANALG-TFLQ-EK---G----H------------------------------------------------------------Q-----G-TVFLGSVKTN-IGHTEAAAGILGVIKILLMMKHNKIVPSLH-C---D--E--VNPKIN-LTELGLKIPR--EII-PWVS--K-------TKTAGCNSFG-FGGSNGHAVIKQYT----VE--Q-D----------Q------H-G-NAQ------------MK-----N-------SYQLICFSGNTERSVKGSL-------------------- 342 --------------------------ISGMGIRLP-G-V---NNYEDLSDILE-CGYLGK-D--V-D--EPHC-GDK---FFG--------------MNKRCRHFD------H--PG-KVDCDFFNISL-DEVYDSNDMVGPLLEVVAECIMDSGLRF--------DDVAKV--KTGFYL---------------------------------------G-MLN-----DRF-HS---------------------GQLFNSAQYLNTGGELCLKVAEKFDLKGPV------QKVHGAEASSFVALHAALLDINAKRCDFAIVAGANLAQDP-NLSLRHQRSNSVSACGQRPLCDKSAN--------------------------------------------------------------------HVFTSDGIIALLLKPNN-C--------------VWPTR----TYCD-VVGFGLQ--FDRQMNN-------S---MFPPNYEAQTRLLRDVYS-K-FCIDV-NDIVYLEANG-----------------------------------------------------------------------A-STQE------G------DKAELKAIN-EVIC-SR--R------------------------------------------------------------------I-----K-PLIVGSIKDV-TGHTEAAAGLLSIVKCITSFQTDTLYPSSS-FT-----L--ANTDIDALSSGKIVIPT--ESC-FLPQ----G-------LMGISSSS-VEGSIGHVVLRRCQ----ST--P-H------K---A------------------------------------------------------LRYPVLL------------------ 343 ------------------------VAISGISGRLP-E-S--N-NMQEFRDHLM-NKEDMV-TA---DNR--RW-EV-------------GI-H--G-VPPRNGKVP--------ELAH-FDAGFFGVHPK-QADCMDPQLRMLLEVSYEAIIDAGESL--------ESVRGS--KTGVFI---------------------------------------G-VSLSES--IEAW-SS---D------------P--E-TLVGYSMPGCCRAMFANRISFFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALMNIRMGHIDSAIVGGTNLCLKPNTSLQFTRMGMTAPD-GTCKAFDALGDGYCRSEAIMAVFLQKSK-D--------------C--KR----IYA-TVVHTKTN--SDGYKEQ-------G---ITFPSGQIQKQLIQEVFDE-A-GINP-KDIAYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNSIV-DVFC-K--D---R----------------------------------------------------------------E----T-PLLIGSTKSN-MGHPEAASGLSSIAKILVAMEERVIPPNLH-Y---Y--S--PNPDIPGLADGRLQVVT--ECT-KWNG-----------GLVAMNSFG-FGGSNVHIIYKSH--D--KE--Q-G------E----PHM--AS-E-------------------------L------PRLFTYSARTEEGVRAIL-------------------- 344 ------------------------VAISGISGRLA-E-S---DNMEELRDNLM-SKVDMI-TE---DER--RW-KQGF--------------C--G-LPTGTGKIK--------DVTK-FDAAFFGVSPK-QAKVMDPVLRMLLEVCYEAIVDSGNTL--------QSVRGS--RTAVIT---------------------------------------G-ISANES--YIV--WM---Q------------P--E-VNTGYPILGCSRAMIANRISYAFDLTGP------S--------------------------------------------------------------------YTVDTACSSSSMALDQALQMIRQGVCDSALVCGTNINISPLYAVCFVKLGMSSPD-GRCKSFDASGDGYGRSEAVMAVFLQKTD-D--------------C--KR----IYA-TMVHSKAN--CDGYKEE-------G---ATFPSSRIQRRLMEEVYSE-A-GVSP-KDVAYFECHG-----------------------------------------------------------------------T-GTSA------------GDPQELKAIT-EVFC-K--D---R----------------------------------------------------------------D----K-PLLIGTIKSN-LGHTESPAGLSSVAKIIIAMQERTIPPNIH-Y---K--N--PNPGIAGLVDGRLQVVT--EPT-KWSG-----------GLMAMNSFG-FGGANVHCLFRSY--E--KE--T-N------G----PHM--AS-A-------------------------K------PRLFTYVGRSEDGVRAVL-------------------- 345 ------------------------IVVSGMSGRIGQ-C----DDLLEYKDMLW-NKRDGF-T--T-K--PLRY-DIE---LY-------------G-TQKRHAYFN--------DAEK-FDSDYFGIAPK-NAEFLDPCIRLGMEAAYEAVIDAGYSA--------QEIRGT--MTGVYV----------------------------------------PCVAYEA--NCYW-LS---K------------GLDV-IGTASRGLGVINNFRASRISFSMDLRGPS------MCIDTACSGYLAAVETAVKDIRLGVCDQAIVAACQMHANP-MGSLLFMELGAAGPDACCYSFDHRAQ--------------------------------------------------------------------GFGRCESAGAMLIQKEE-D----------------ARR----VYCK-IPHVYQS--CDGASTD---------HDFNHPSEVGQKHTIEECYRQ-A-NIDL-NKIEFVECHG-----------------------------------------------------------------------T-GTKA------------GDLVECNAID-SAFC-SK-P---R----------------------------------------------------------------S----K-PLMIGSCKSN-VGHAEASAGFNAMVKCIFSINECVIPPNIN-YE-----K--PNPTIAGLLEGRLKVPT--ELT-PWSG--E---------MCGISGFG-IGGTNSHMILKKND----KP--N-T------T---I-HP--SS-G-------------------------A------MRLFCYHARTEDGLRNIL-------------------- 346 ------------------------IVVSGMSGRIGQ-C----DNLLEYKDILW-NKKDAY-T--T-K--SMRF-DIE---EY-------------G-TQYRHAYIN--------DAEK-FDSDYFGIAPK-NAEFLDPSIRLAMEATCEAIIDAGYSM--------QEIRGT--NTGVYV----------------------------------------PAVAYDS--YAFW-LA---K------------NVDT-IGSASRGMGVMITFRATRISFALDLRGPS------TIVDTACSSYLAAVETAVKDIRLGMCDQAIVPFCHMLVNP-MGSKLFLEIGGCGPNAACYSFDARAE--------------------------------------------------------------------GFGRCEGMGALFIQKEN-D----------------ARR----VYCK-IPSIYQS--CDGDSTS---------VGFNNPSIIGQRHTIEECYKR-A-NIDM-SKIEYVECHG-----------------------------------------------------------------------T-ATMA------------GDIAEGNAVD-EAFF-SK-P---R----------------------------------------------------------------T----K-PLLIGACKTN-VGNGEAGAGFNAMVKCIFSIKERMIPPNQN-FE-----T--PNPEIPGLMEGRLKVPT--ELT-PWSG--D---------VCSINAFG-IGGTNCHMILTKND----KP--N-T------S---T-HP--SS-G-------------------------A------MRLFCYNARTEEGLRNIL-------------------- 347 ------------------------IVVAGMSGRVGQ-C----DTLDDFKEMLW-QGKDGF-T--T-K--SMRF-DIE---KY-------------G-TQKRHAYIN--------DAEK-FDADFFGIAPK-NAEFLDPCIRLTMEAAYEAVVDAGYSA--------QEMRGT--KTGVYV----------------------------------------PCVSYEA--NCYW-LS---K------------GLDV-IGTASRGLGVINNFRASRISYSMDLRGPS------MCLDTACSGYLAAVEAGVKDIRLGICDQAIVASCQTHCNP-MGSLLFMDLGAAGPDACCYTFDERAQ--------------------------------------------------------------------GFGRCEAVGAMLIQKEE-D----------------ARR----VFAK-IPHVYQS--CDGASTE---------HDFNHPAVPGQRWTIDECYRQ-A-GIDK-NKIEFVECHG-----------------------------------------------------------------------T-GTRA------------GDRVEADAID-FSFC-AK-P---R----------------------------------------------------------------A----K-PLWVGSVKTN-VGHAEASAGFNAMVKCIFAMNECLIPPNLN-FA-----K--PNPTIAGLLEGRLKVVT--ELT-PWGG--E---------MCGISGFG-IGGTNSHMIMKRND----KP--N-T------S---I-HP--SS-G-------------------------A------MRLFCYHARTEDGLRNIF-------------------- 348 ------------------------IVVSGMSGRIGQ-C----DNLLEYKDILW-NKKDAY-T--T-E--SMRF-DIE---HY-------------G-TQKRHAFIN--------NAEK-FDSDYFGIAPK-NAEFLDPSTRLPMEAAIEALIDAGYST--------QEMRGT--MTGVYV----------------------------------------PAVAYDS--WSYW-IS---K------------NLDA-VGTPGKALGVFANFRASRISHALDLKGPS------VVVDTACSTYLAAVDTAVKDLRLGLCDMAIVPFGQLLCNP-FGSLLLMELGALGPNSACYSFDARAE--------------------------------------------------------------------GFGRCEGMGALILQKEE-D----------------ARR----VYCK-IPSTYQS--CDGAQSE---------GGFCSPSINGQKHTIEECYRR-A-NIDL-DKVEYVECHG-----------------------------------------------------------------------T-ATQA------------GDIAEGNTMD-AVFC-SK-P---R----------------------------------------------------------------S----K-PLLIGSAKTN-VGNAEAGAGFNAMVKCIFSIKECMIPPNQN-FE-----T--PNPGIPGLLEGRLKVPT--ELT-PWSG--D---------VISCNGFG-VGGTNAHVILKKND----KP--N-T------S---I-HP--SS-R-------------------------D------TRLFCYNARTEEGLRDIF-------------------- 349 ------------------------VAIGGISGRMP-E-S--N-NMQEFRDHLM-KKEDMV-TS---DNR--RW-EV-------------GL-H--G-TPPRNGKLK--------EIDR-FDAGFFGVHPK-QADCMDPQLRMLLEVSYEAIIDSGQSL--------QSVRGS--RTGVFI---------------------------------------G-VSIAEA--SEAW-SA---D------------P--E-TLVGYSMPGCCKAMFANRISFFFDFKGP------S--------------------------------------------------------------------YSVDTACSSSMMCLDQALLNIRMGIIDSALVGGSNLCLKSQTSLQFVRMGMTAPD-GSCKTFDASGDGYCRSEAIMAVFLQKSA-D--------------C--KR----IYA-TLVHSKAN--ADGYKEQ-------G---ITFPSGILQKRLITEVYDE-I-GINP-TSIDFMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINTVV-DVFC-K--G---R----------------------------------------------------------------E----T-PLLIGSTKSC-MGHPEAASGLTSMAKIFIAMEERIIPPNLH-Y---K--T--PNPEIPGLTDGSLQVIT--ECT-RWNG-----------GIVSMISFG-FGGANVHAVFRSH--D--KE--Q-G------E----PHM--AS-E-------------------------K------PRLFTISARTEEGVRAVI-------------------- 350 --------------------------IAGVGLRLP-K-A---NNLDELADLLE-KGRTCF-D--D-T----RW-QKG---LFG--------------MDHTCGRVE------P--IG-EMDCEFFNISP-EEAYCAPHMLAPLLEVVAETIMDAGLTL--------ASVAKL--TTGLYL---------------------------------------A-MTLCDT--DYG-HA---------------------ENVSEHSQFLNTGSELSSRVSQRFGLRGPV------QHVDGACASSFVALHAALVDLTAGRTDLAIVVGSNLVQDP-MPSLQFDRMNMTSPHGKSLPFDERAD--------------------------------------------------------------------GYVRSDGIVAYLLKLPD-S---------------VPTR----EYCD-IIAFDLQ--NNGKRQQ-------G---ITNPNHKFQAKLLSDVYK----HIDV-NDLAYFEAHG-----------------------------------------------------------------------T-STQK------G------DRAELTAID-STLC-RR--R------------------------------------------------------------------Q-----Q-PLVVGSLKAT-LGHTEATAGFAGIAKCLAIFKKQTIFKMPN-FK-----T--PNPTIEALMNGHVVIPT--SNI-ALSK----D----PRVLLGVSTYG-FGGLGGHVVLRRKQ----DS--K-G------S---P------------------------------------------------------L-----P------------------ 351 ------------------------VAVSGISGRMP-E-S--A-NVQEFRDHLM-NKEDMV-TA---DNR--RW-EI-------------GL-H--G-LPPKNGKVP--------EIDK-FDAGFFGVSAK-QADVMDPMLRMLLEVSYEAIVDSGNSL--------ENVRGS--RTGVYV---------------------------------------G-LTIGES--NEAW-SV---D------------P--E-TLVGYSMSGCCPAMFANRLSFFFDFKGP------S--------------------------------------------------------------------YTLDTACSSSMMCLDHAVSGIRMGLIDSAIVAGCNLCLKAQTSLQFTRMNMTSPD-GLCKSFDASGNGYCRSEAVSAIFVQRST-D--------------C--KR----IYA-TVVHTKSN--TDGHKEE-------G---ITFPSGQMQKELIQEVYKE-I-GMDP-SKINYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNTIV-DVFC-K--N---R----------------------------------------------------------------N----T-PLLIGSTKSN-TGHPECASGLTSLAKIIISMEERVIPPNLH-Y---N--T--PNPDIPGLVDGSLKVVT--ECT-PWNG-----------GFVSMNSFG-FGGANVHVIYRSN--D--EE--R-E-----------PHE--AS-D-------------------------K------TRLFTYSGRTEEGVRAVL-------------------- 352 ------------------------VVIAGMSARLP-H-S---KDVDEFTKNLY-DRVYMN-TT---TEKAGRY-EEG-------------L-Y--G-NQRIMCAID--------DLDK-FDAPFFLFHPF-MAKVTDPGHRIVQEKVYEAIIDAGESM--------ESMKGT--KTGVFC---------------------------------------G-ALASDS--QEMN-RS----------------I--D-RMTAYSFIGSVSCHLANRISYFFDLKGP------S--------------------------------------------------------------------FTLDSACASVLAALDCAMSQIRLGVIDHAIVATTNLALDPLASLTATTVGMLCDD-GKCKAFDARANGFVRAEANVAILLSKKH-L--------------A--KR----QYC-QVLHTKGS--SDGFTPA-------G---LSVPSSDAQSQLIRDVWAD-L-NIDP-NKVAYAECHG-----------------------------------------------------------------------P-GTQV------------GDGVEVDAIA-DVLCTN------R---------------------------------------------------------------EGS---D-PLYIGSVKTN-MGHCEGSSGMASIIKCVIGIHNQQIPPNLH-F---S--T--PNPNIRSLHDGRVKVAT--EPR-PHRE-----------GFISISSFG-VGGSNYNAVLKST--H--SP--A-T------T---Y-HP--DS-D-------------------------A------PRLFVYGARTASGAHSVM-------------------- 353 ------------------------VAISGISGRMP-E-S--A-NMQEFRDHLM-KKEDMV-TA---DNR--RW-EV-------------GL-H--G-TPPRNGKLK--------EIDR-FDAGFFGVHAK-QADCMDPMLRMLLEVSYEAIIDSGQSL--------ESVRGS--RTGVYI---------------------------------------G-VSIAEA--IEAW-ST---D------------P--E-TLVGYSMPGCCKAMFANRISFFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALMNIRMGLIDNALVGGTNLCLKPQSSLQFTRMNMTAPD-GTCKSFDASADGYCRSEAVTAVYLQKSA-D--------------C--KR----IYA-TLVHTKCN--SDGYKEE-------G---ITFPSGIMQKELINDVYNE-I-GINP-TDIAYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNSIV-EVFC-K--D---R----------------------------------------------------------------K----G-SLKIGSTKSN-MGHPEAASGLTSLAKIIIAMEERVIPPNLH-Y---H--N--PNPEIPGLTDGSLQVVA--ECT-NWNG-----------GLVSMNSFG-FGGSNVHAVYRSY--D--E---Q-R------E----THE--AS-A-------------------------K------PRLFTYSGRAEEGVRAVL-------------------- 354 --------------------------ISGVAGRFPK--S---NNVQEFWMNLV-DGVDML-G-------PTRW-PPG---LHG--------------LPPRSGSIP------D--LGT-FDAEFFGYSE-TEARHCNLLLRLLLEVTYESVVDSGLTL--------SSLRAD--KTGLYL---------------------------------------A-CTFSDA--DVI-TN---------------------SAA-TDSEHINLRSTLVQQLNTWYRFQGPV------MTVDTACSSSVSALQMAVTDLITGRCNYAVVTGVNLILSP-NCSQSFNRLGMLSPTGESHVFDISAN--------------------------------------------------------------------GYVRSDGVAVVILARNP-E---------------RCER----IYAT-IADIAVN--CDGYKEE-------G---IVYPSRSSQSNLLRSLYG-E-KLIPT-SSLAYVEAHG-----------------------------------------------------------------------T-GTQA------G------DRLELNAIM-DALC-DG--R------------------------------------------------------------------D-----E-PLLVGSVKSN-MGHCEAASGLSAVVKCILSIYHGMVPACLH-YK-----T--PNEGIEGIPLGKIKVVD--ICH-KLKG----R----I-SIMGINSFG-FGGVNGHLILMSYK----NP--P-D------E---P-KR--S----G------------------------------TYLVPITVRNEEGVAKI--------------------- 355 ------------------------ICITGFSGRLP-E-S--S-NIEEFKRNLM-EGVDMV-ND---DDR--RW-PKGL--------------Y--D-LPTRIGKIK------DEDLQN-LDAEFFKIHQK-QAECMDPQMRMLLECTYEAIIDAGINP--------QELRGS--RTGVYI---------------------------------------G-CSNSET--EQHW-CA---D------------P--D-LVNGYGLIGCARAMFANRLSFTFDFKGP------S--------------------------------------------------------------------YAVDTACSSSLIAMSTAFADMKAGRCDAAIVAGCGIILKPTMSLQFKRLNMLGKE-GMCKVFDESGNGYVRSDGCVVTFMQRAS-D--------------S--RR----IYA-SVLNVRIN--TDGYKEQ-------G---ITFPNGAMQKRLIQETYGE-I-NLNP-ADVVYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNNIT-DFFC-K--D---R---------------------------------------------------------------KA------PLLIGSVKSN-MGHSEPASGVCSIAKMLIAMEAGIIPGNLH-F---K--N--TNPDLYGIMDGSVKVVD--RNL-PWNG-----------GIIGLNSFG-FGGANAHVIMKSY--P--KP--K-P-----------VSP--KD-G-------------------------F------PKLVFASGRTEEAVEAFL-------------------- 356 ------------------------VVISGISGRLP-E-S--D-NIEEFRQHLM-LGEDMV-TE---DNR--RW-EPGL--------------L--G-LPRRNGKLK--------DLSK-FDAAFFGVSPK-QAETMDPQQRLLLETAYECIVDAGVNP--------QTLKGT--KTGVFI---------------------------------------G-SSFSEA--AEAW-SS---N------------S--E-KMIGYAMTGCCRAMFANRLSFFFDLKGP------S--------------------------------------------------------------------YTVDTACSSSLLALDLALHSIRMGQCDAALVGGCGLLLKPASSLQFLQLNMLSPD-GMCKSFDASGNGYCRSEAVVMVLLQKSS-D--------------A--KR----IYS-TVVHSGNN--ADGNKEQ-------G---ITFPSGEMQKQLLKQVYAD-A-GVDP-AKVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNGIC-DIFC-K--G---R----------------------------------------------------------------Q----Q-PLLIGSTKSN-MGHPEPASGLAAVAKVVIAMEDGMIPPNLH-Y---E--N--PNPDIPGLLDGRLAVVT--HRA-RWDG-----------GYVGINSFG-FGGANVHVILKSN--E--QE--R------T-A----THP--DA-A-------------------------S------CRLFTYAGRTEEGVKRVF-------------------- 357 ------------------------VVISGISARLP-E-S--D-NMEEFRQHLM-QGEDMV-TE---DDR--RW-SPGL--------------Y--G-LPRRNGKLK--------DLSK-FDAGFFGVSGK-QADSMDPQLRILLETSYECIVDAGINP--------QSIRGT--RTGVFI---------------------------------------G-SSFSEA--AEAW-AS---D------------T--E-KTIGYAMTGCCRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------FVVDTACSSSLLALDQALHSIRNGHCDAAIVGGCGLLLKPGTSLQFLQLGMLSPE-GKCKSFDASGNGYCRSETIGTLFLQKVS-A--------------A--KR----IYA-TVVHTGNN--ADGNKEQ-------G---ITFPSGQVQKELLKQVYTQ-A-GIDP-SSVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIA-DIFC-K--D---R----------------------------------------------------------------Q----G-PLLIGSTKSN-MGHPEPASGLAAVAKVLIAMEDGVIPPNLH-F---E--E--PNPDIPALQDGRLSVVT--HCK-QWNG-----------GYVGINSFG-FGGANVHAILKSN--E--KN--P------A-S-----HS--DA-Q-------------------------S------CRLVTYSGRTEESVQRVL-------------------- 358 ------------------------VVITGISARLP-E-S--D-NIEEFRQHLM-AGEDMV-TE---DDR--RW-QPGL--------------H--G-LPKRNGKLK--------DLSK-FDAAFFGVSPR-QADAMDPQLRLLLETTYECIVDAGVNP--------QSIRGT--KTGVFI---------------------------------------G-SSFSEA--AEAW-AC---D------------P--E-KTTGYTMTGCCRAMFANRLSYYFDFKGP------S--------------------------------------------------------------------YVLDTACSSSLLALDQALHSIRNGHCDAAIVGGSGLLLKPVTSLQFLQLGMLSPE-GMCKSFDASGNGYCRSETVGTVFLQKSK-D--------------A--KR----VYA-TVVHTGTN--ADGSKEQ-------G---ITFPSGEVQKDLLQRVYTQ-A-NINP-SSVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIT-DVFC-K--D---R----------------------------------------------------------------Q----G-PLMIGSTKSN-MGHPEPASGLAAVAKVLIAMEDGVIPPNLH-F---E--E--PNPDIPGLQDGRLSVVT--QCQ-PWQG-----------GYVGINSFG-FGGANVHAILQSN--Q--KE--R-V----E-S----PHP--DA-N-------------------------S------RRLLTYSGRTEESVRHVL-------------------- 359 ------------------------IAIIGAAFKGP-G-A---DNLEELWGVLE-RGENHV-TDIP-K--E-RW-NNDA--FYD----PDPQAVTKS-YVCKGGFM-----S-K--PF-AFDNSFFDINDM-ESDQMDPQQKHALECTYRALEHAGLNK--------QDLKG--SKTGVYI---------------------------------------G-AMNSDY--RSMY-QA-----------R----S--S-GVTNYTVTGISNSIIAARISFFFDLRGPA------LVLDTGCSSALIAIHTASQALRAGDCDLAICGGTNFMMTP-DIFVHLSKAKMVSPTGQCYAFSDKAD--------------------------------------------------------------------GYTRGEGCGIVVLKKLS-D--------------A--QRDGDRVLA-TIE-TGTN--QDGHSVT-------P---ISAPSMKQQLCLLEHTYRN-L-TDQDLEELDYIEAHG-----------------------------------------------------------------------T-GTIT------G------DPTEATALG-KFFQ-RR---G----S------------------------------------------------------------I-----K-VRKIGSIKTN-IGHLESAAGVAGLIKVLLMMEHSKIVPTLF-SE-----D--PNKKIN-FEKLKLTLPT--KVV-DWRK--D-------QHVACVNSFG-FGGSNCHAIVKSKK----KE--T-V------R---R-S-----------------------CE-----G-K------PAVVCFSGKSENSLRGSL-------------------- 360 ------------------------IVISGVSGRFP-K-G---KNMAEFAENLM-TKTDVY-QS---KE--KRW-GK--------------V-A--D-VPDMMPVVD--------DGDK-FDADFFLSNPR-FSDCTDPYTRMILECTYEAIVDAGESI--------ESMWGT--KTGVFS---------------------------------------A-SGGVDV--ASG---T-------------------E-QVDPYVFQVNTASFVPNRICYIFDLKGT------S--------------------------------------------------------------------YIVNGHTTSSLAAIDQAVLEMRHGYVDMAIVTGHSLAMEPFQTVASLVNGIASPD-GRARSFDANANGVARGEDAVVILLQKRS-R--------------A--KR----VYA-SVLHCKGL--DTGFNPS-------G---ILQPSADAQATLMKEVYGE-L-GINP-AKVNYVEATG-----------------------------------------------------------------------S-GVPD------------YDVAEANAIG-TVMCPG------R---------------------------------------------------------------K-----D-PLYIGSVTSN-IGLCDAGSGLAAIAKVLISMETGRIPPTDL-Y---T--S--PNPRIPDLVQGRLKVVD--KVT-PWQS-----------DLAGVNSYS-FGGALYHCCLKAD--P--EE--K-R------P---P-HP--AS-N-------------------------A------PRLFTFNARTADGVK--K-------------------- 361 ------------------------IVVSGMSGRLP-S-C---YNLQDFHDKLY-NKVDLI-TP---TD--IRF-PSG-------------V-M--D-LPKDMGIIY--------EADR-FDAEMFHFTRE-MAKATDPKMRMLLETTYEALADAGETM--------QSVKGT--RTGVYV---------------------------------------G-TLGFDY--MES--IT----------------A--E-RITGSSYVGNNMAYLSQWISHAFDLQGP------S--------------------------------------------------------------------ITLDSACSSSSMALSQAVLNIRRGHIDAAIVGGSTMVMDPLACKVIDLSSAMSPD-ARCKTFDASANGYVRSEGVVIFYVTKES-L--------------A--KR----IYV-SVLNVRGN--TDGYKPV-------S---MAAPSRAAQMRLMTDVVDG-V-GIDR-SKISLAEAHG-----------------------------------------------------------------------T-GTIA------------GDGQEADGIA-QILCSV------P---------------------------------------------------------------RD----E-PLLISSVKSC-VGHTEGAAGLASMCKVIFGMENELIPPNLH-F---N--V--PNPSIQCLHDGRVKVVT--EPT-PWKG----------QLLATVSAFG-IGGSNYIACLRSH--K--NR--T-T------P---P-HP--AS-K-------------------------A------TRVVCYCARSEEAAERVL-------------------- 362 ------------------------LCISGLSGRIGS-N----DDMQEFKDMLF-NKGDGY-KS-A-T--KHRF-DAE---SY-------------N-WHARVSYLN--------ELDK-FDYEFFSLPKI-NAETMDPGLRIMLEVTYEAMVDAGLSL--------KDVQGS--RTGVYV----------------------------------------SNMYHEA--IALW-IDPKGG------------RYDP-TRMAKSGLGCANSFKAGRISNFFDLKGPS------VHFDSACTSFFSALDGAYAHLRAGVIDAAVVAGCNMSMMP-NISMFFKEMGATGPTGTCYAFDHRAE--------------------------------------------------------------------GFARGECVGALWIQKEK-D----------------SKR----VYAK-LVHTRQS--HDGYDAE---------HDFTFPSQDAQVDLLHDIFAD-T-ELDP-HKIEFVECHG-----------------------------------------------------------------------T-GTNA------------GDPTEVGGLD-RVFC-GE-G---R----------------------------------------------------------------T----K-PLLIGSVKTN-VGHGEAMAGFNSLVKVAMAYEEETIPPNIN-FE-----K--PNPNIPALVDGRIQVVS--ENT-PWAC--G---------HASICSYG-MAGSDAHAILKKND----RA--V-S------A---N-HP--DA-D-------------------------S------ARLVTYAARTEEGLARIL-------------------- 363 ------------------------------------------------------------------------------------------------------------------------------------------MLKLFLLVS-------GLTL--------QSVRGS--RTGVFI---------------------------------------G-VSQSES--SEAW-ST---D------------P--E-TLIGYCMPGCCRAMFANRISFFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQAVAGIRAGTIDSAIVGGCNLCLKPQTSLQFVRMGMVAPD-GSCKTFDASGDGYCRSEAVSALFLQKSK-D--------------C--KR----IYA-TVVHTKSN--CDGNKEQ-------G---ITFPSGILQKQLIKEVYDE-I-QIDP-KDIAYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINTVV-DVFC-K--D---R----------------------------------------------------------------E----G-ALKIGSTKSN-MGHPEAASGLTSIAKIIIAMEEGVIPPNLH-Y---K--T--PNPEIPGLTDGSLEVIT--ECT-KWDG-----------GLVAMNSFG-FGGANVHAIYRS------------------------------------------------------------------------------------------------------- 364 ------------------------VVISGISGRMP-E-S--A-NIEEFRDHLM-KKEDMV-TA---DNR--RW-EM-------------GL-H--G-MPSRNGKVK--------ELRH-FDAGFFGVHPK-QADCMDPQLRMLLEVAYEAIVDSGQTL--------ESVRGS--RTGVYV---------------------------------------G-VSQSES--SEAW-ST---D------------P--E-TLIGYCMPGCCRAMFANRVSFFFDFKGP------S--------------------------------------------------------------------FALDTACSSSMMGLDLAVHSIRSGVIDAAIVGGTNLCLKPQTSLQFVRMSMVAPD-GSCKTFDASGDGYCRSEAISAVYIQKAK-N--------------S--KR----LYA-TIVHSKSN--CDGFKEQ-------G---ITFPSGILQRELIDEVYKE-S-GINP-HDISYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINTVV-DAFC-K--G---R----------------------------------------------------------------S----V-PLKIGSTKSN-MGHAEAASGLTSIAKIIISMEEGVIPPNLH-F---K--N--PNPKIPGLTDGSLQVIT--ECT-KWDR-----------GLVAMNSFG-FGGANVHVIYKSN--D--KV--Q-T------E----PHA--AS-Q-------------------------K------TRLFTYGARTEEGVRAVL-------------------- 365 ------------------------VCITGISGQSGS-C----MNLDELKEVLL-TKDHAF-KF-A-K--L-RF-DEELAKKY-------------E-MYIPEALTD--------NWEW-FDWDFFNTSTK-IAEYMDPPLRKIMEAVYEAITDAGVTM--------KELKGT--NTGVFL----------------------------------------TAPVPEV--HQIF-L-DFDN------------NPDK-ANRNRSNTGVHNCMKPGRVSHSFDLKGSS------MVIDNACSSVPTSVEIATGQMRSGVIDRAIICGANTLFYP-ITSKLYHEMNLTNVEGRCFSFDARGN--------------------------------------------------------------------GYARNETLGALFIQRRS-E----------------SKR----IYTK-ILNITQG--CDGLDED---------HDYGHPSMPGQIGVMKKLYNQ-T-AVDP-KTIEYVECHG-----------------------------------------------------------------------T-GTPA------------GDPIELGSIN-AVMC-GE-G---R----------------------------------------------------------------T----K-PIYVGSVKSN-VGHGECMSGWNAIAKVILAQEEGVLLPNIN-FE-----T--PNPLIPSLLEGRIKVCT--EVT-PMET--R---------IAAINSFG-FNGSDTHILLQAEE----R---R-E------V---K-HP--DS-D-------------------------S------LRLFTYSARTEEGLSSIF-------------------- 366 --------------------------------------------------------------------------------------------------------------------DT-YDWEFFNTSVM-LAEWMDPQMRKILEVVYEAITDAGVTM--------EDLKGT--TTGVYV----------------------------------------TAQVPEA--SDIY-F-DFEL------------IQDK-RNRVRATTGVVNCMKPGKVSHTLDLKGSA------IFVDNACSSILTCMEIAAGQMRSGVVDRAIVCGANTMFLP-KTSKMYMDMTITNVEGRCYSFDARAN--------------------------------------------------------------------GYARNECCGAFLIQKRS-E----------------AKR----IYSR-IVHVTQG--ADGLDED---------HDYGHPSTPGQTKVIGRLYEE-T-GIDA-TQIDYVECHG-----------------------------------------------------------------------T-GTPA------------GDPTEVASVE-NVFG-GK-S---R----------------------------------------------------------------K----N-PITVGSVKSN-LGHGENMAGWNSVCKMIFGFEEGVLIPNIN-YE-----T--PSPLIPGLLEGRVKVCT--EVT-PFDK--N---------MVAINSFG-MNGTTGHCLLQADD----WS--K-D------P---K-HP--NS-E-------------------------S------LRLFTYAARTEEGLNGIF-------------------- 367 ---------------------------------------------------------------------------SN---FYG--------------ISQRTGRIS------A--FG-KMDCQYFNKTY-QEASNSPSMLGLLLQVVAESVLDSGLQM--------KQVAGK--GTGFYL---------------------------------------G-STFADT--DCL-NK---------------------P---RSSGMLNSRTYLTSQVSHHFDFQGPV------LQTDGACASSFTALHCALMDLQAGRCRIAIVAGVNLIEDP-LVSMQFAKLNMTSPTGDSRPFDKDAN--------------------------------------------------------------------GYVRSDGIAALLLKRNT-H--------------DPPSR----LYCE-IVGFGLQ--CDGFRPQ-------G---IVSPNHKFQTELLNEIYE-K-YHIDV-NDLVFVESHG-----------------------------------------------------------------------T-STQK------G------DKAEVKALS-QALC-RK--R------------------------------------------------------------------D-----R-PLVVGSIKGN-IGHTESTAGLAGILKCIASYRINTIFKNIN-LS-----V--LNPAIQSLHTGEIIIPT--API-PLSK----D----GPNLMGVSSFG-FG----------------------------------------------------------------------------------------------------------------- 368 --------------------------ISGISGRSGS-N----LNLDEFRDMLL-TKGDGY-KF-S-D--AGRF-DRD---KC-------------D-FHIPQALTK--------GWDR-FDWDFFTMTRF-VTDFMDPQLRKSLEAVYEAITDAGVSL--------DDIRGT--NTGVFL----------------------------------------CASEPEC--LTWL-D-PND--------------SKI-AERVRAGTGISNNMKVGRISNFFDLKGPS------LYIDSACASVLVATEIALANLRAGVIDRAILCGSNSMFLL-NTSRLYKEMTIINDEGRCFSFDARGN--------------------------------------------------------------------GYARSECVGAFLIEKES-E----------------CKR----IYTK-LLHVTQG--SDGYDPD---------HDYGHPSTKGQVRVIERTYKE-T-GIDP-KTIQYLECHG-----------------------------------------------------------------------T-GTQA------------GDLTELASLD-AIFC-GE-G---R----------------------------------------------------------------K----N-PLLIGSVKSN-LGHGEIMSGFNAVAKMIIAFQENCLPPNIN-FV-----T--PNPNIPSLIEGRVKVVE--EVT-PLNG--Q---------IFGINSFG-LNGADVHMILQAPD----RS--E-S------K---Q-HP--SS-E-------------------------S------LRLFTYAARTEEGLTNIF-------------------- 369 ------------------------VAITGISGRMP-Q-S--A-NIQEFRDHLM-NKEDMV-TA---GSE--RW-EM-------------GF-H--G-LPARNGKLK--------ELKH-FDAAFFGVHAK-QADFMDPQLRLLLEVCYEALVDAGQSL--------ESVRGT--RTGVFI---------------------------------------G-VSESEC--SDAW-GS---D------------P--N-TVVGYGMLGCCRAMFANRVSFFFDLKGP------S--------------------------------------------------------------------YALDTACSSSTTCLDHALFNIRAGKIDAALVGGATICIKPQTSQQFHGMGMMAPD-GSCKTFDASGDGYCRSEAIPAIYLQKAG-D--------------A--KR----IYA-TVVHSKAN--CDGFKEQ-------G---ITFPSGVLQKQVIEEVYEE-T-GINP-ADIDYMEAHG-----------------------------------------------------------------------T-GTRV------------GDPQEINTIV-EVFC-R--N---R----------------------------------------------------------------N----S-PLKIGSTKSN-MGHAEAASGLTSIVKIIIAMEEGVIPPNLH-Y---K--S--PNPEIPGLTDGSLQVIA--DCT-EWDG-----------GLVAMSSFG-FGGANVHAILRSH--D--KT--D-R------S----PHP--AS-D-------------------------K------LRLFTYGARTEDGVKLVL-------------------- 370 --------------------------IAGVGFRLP-G-A---KNLDELATLLE-EGECVL-R--P-P----RC-GTD---LYG--------------MTQHTGQVK------D--YG-TMDCQYFNMTR-QQARDCPPMLGMLLEVVAESVMDSGLTM--------MDVAGS--GTGFYL---------------------------------------G-ATFADT--DLL-NR---------------------E--QMTSQLLTNRTSLTAHVTHHFDIQGPA------LQMDGACASSFAALHSAIQDLGAGRCDVAIVAGVNLIEDP-LVSVQFAKMGMTSPSGESRPFNEGAN--------------------------------------------------------------------GYVRSDGVAALLLKKNL-K--------------EPYSR----IYCD-VVAFGLK--CGGAREQ-------G---IVHPSHKFQSELLREVYG-Q-HNVYP-KDIVYVEAHG-----------------------------------------------------------------------T-STQK------G------DKAEMKALH-EVFN-RT--P------------------------------------------------------------------K-----D-PLAVGSVKGN-NGHCESTSGPVNLICELSQFFLR---RRIH-WP-----L--KEIDVS------------------------------------------------------------------------------------------------------------------------------------------------------------- 371 ------------------------ICITGLSGRSGS-N----LDMDEFREMVM-NKEDGF-KN-E-N--EIRW-DKE---AR-------------E-MSIPHGFTG--------DLDK-FDYEFFMVPRV-TAECLDPSLRVLFEVVYEALADAGVSI--------QEVAGL--KTGLYL----------------------------------------SPG------MTFA-K-PVD-------------AKDP-TERVNKAIGSSTGLMAGRVARFFDISGPA------VVMDNACSSFFSIVEYATHHIKSGLVDTAILCGANTACTP-DTSIIYNGIGTLNSRGRCFTFDASGD--------------------------------------------------------------------GYARCECIAATVLQRAS-K----------------AKR----IYSR-ITHVAMG--CDGRDED---------RDFLQPSSKGQTMHLNQAFKE-C-GLDP-KKFEYVECHG-----------------------------------------------------------------------T-GTPI------------GDPTELEGID-NVFC-GK-G---R----------------------------------------------------------------T----K-PLLVGSIKSN-LGHAESMSGWNAIAKMVVAFEERVIPPNIN-YF-----T--PNPNIPALVEGRVKVPT--EPT-PWSG--E---------HSALCSYG-MQGLDVYIILSGHD----KS--P-S------I---P-HP--SA-G-------------------------S------TRLFTYGARTEETLQELL-------------------- 372 ------------------------IAISGISGRMP-E-S--A-NMEEFRDHLM-KKEDMV-TA---DSR--RW-EM-------------GL-H--G-MPTRNGKLK--------EIRH-FDAGFFGVHPK-QADCMDPQLRMLLEVSYEAIVDSGQTL--------ESVRGS--RTGVFV---------------------------------------G-VSQSES--SEAW-ST---D------------P--E-TLIGYCMPGCCRAMFANRISFFFDLKGP------S--------------------------------------------------------------------FAVDTACSSSMICLDHAINSIRSGHIDAAIVGGTNLCLKPQTSLQFVRMGMVAPD-GSCKAFDASANGYCRSEAISAVYIQKSK-D--------------C--KR----IYA-TVVHTKSN--CDGYKEQ-------G---ITFPSGILQKQLLEEVYEE-S-GIKP-TDIAYVESHG-----------------------------------------------------------------------T-GTKV------------GDPQEINTVV-DVFC-K--G---R----------------------------------------------------------------N----K-PLKIGSTKTN-MGHPEAASGLTSIAKIIISMEEGVIPPNLH-Y---N--N--PNPEIPGLTDGSLQVIS--ECT-KWER-----------GLVAQNSFG-FGGANVHAIYRSN--D--KV--K-T------E----QHP---------------------------------------------------------------------------- 373 --------------------------VAGMSGRLP-K-C---SNLQQFSDKLY-SNVDLI-SP---TD--ERF-PAR-------------T-I--N-LPAEMGVIN--------DAGK-FDAGMFDFTRE-MAKASDPKMRLLLEATYESISDAGETM--------ESLKGS--RTGVYI---------------------------------------G-TLGFDY--VET--LT----------------R--E-RLTKTSFYGNNMAYLSQWISYFYDLKGP------S--------------------------------------------------------------------VVLDSACSSSSMAMTQAILNIRRGHIDAAIVGGATLITDPLASKVIDLSGAMSPD-SRSKSFDASANGYARSEGIMVFYVTKKH-L--------------A--KR----LYA-TILNVRGN--ADGFKPL-------S---MAAPSRDAQVKLMSDVLDT-V-GIDR-SKVTLAEAHG-----------------------------------------------------------------------T-GTPA------------GDGPEADGIA-MVLCTQ------P---------------------------------------------------------------RD----Q-PLLISSVKSC-CGHTEGAAGLTSMCKVIFSMENELIPPNLH-F---K--S--PNPAIQCLQDGRANVVA--EAT-PWKG---------DQLVATVSAFG-IGGSNYIACLRSN--I--EK--R-R------P---P-HP--AS-K-------------------------K------PRLICYCARSEVAAKRVL-------------------- 374 ------------------------IVISGISGRFP-M-A---GNMKQFEENML-SQRDVF-QP---KE--MRW-GP--------------T-P--D-VPDNMPLLD--------NSDK-LDCDFFLSNPR-FSDCTDSFTRLVLSATYEAILDAGESF--------DTIWGT--RTAVIT---------------------------------------A-HSGVET--PSG---A-------------------F-NLDPYIFQVNTASFIPNRTSYLYNLSGT------S--------------------------------------------------------------------FTVNGYTTSSMAALDQACMEMRMGYADQAIVTGHCMALEPFQTVAGKIIGMGSPD-GRCRSFDTNASGFGRGEAAVVFLLQKRS-V--------------A--KR----VYA-TIMQVKGM--TKGFSPD-------G---LMDPSMDSQATLMREVYEE-V-GVDP-KKVSYVEALG-----------------------------------------------------------------------T-GVPK------------YDAAEANAIA-NVFCLG------K---------------------------------------------------------------K-----E-PVLMGATASH-IGCAESASGMASIAKCILAMESGKLPPNVL-Y---T--S--PNKDVPALANGQLKVLD--KVT-PCKL-----------DVVGVNSYS-FGGADYHCCLKAH--P--EE--K-R------A---P-HP--AS-Q-------------------------L------LRLFTYSARTAEGVK--K-------------------- 375 ------------------------VAISGISGRLP-E-S--D-NMAEFREHLM-KNEDMV-TA---DNR--RW-EV-------------GL-H--G-NPARNGKLK--------EIKY-FDAAFFGVHPK-QADCMDPQLRILLEVSYEAIIDAGQTM--------ESVRGS--KTGVYV---------------------------------------G-VSLSEA--SDAW-SA---D------------A--E-STVGYTMPGCCRAMFANRISYFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALLNLRMGLIDSAIVAGTNLCLKPTTSLQFVRMGMTAPD-GTCKTFDASGDGYCRSEAIMAIYLQKSA-D--------------C--KR----IYA-TVVHTKTN--ADGFKEQ-------G---ITFPSGIMQKQLINEVYHE-I-GINP-LDVAYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNSLV-DVFC-K--G---R----------------------------------------------------------------K----S-PLLIGSTKSN-MGHPEAASGLTSIAKIVVAMEDHVIPANLH-F---K--N--PNPEIHGLLDGSLQVVK--DNT-PWKG-----------GLVAMNSFG-FGGANVHAIFRSH--E--KE--L-V------E----PHF--AS-D-------------------------K------TRLYTCSARTEAGAKALL-------------------- 376 ------------------------IAIVGIGCRTP-G-A---DNIRDFWRVLV-NGECHV-TDVP-P--D-RW-NAAA--YLS----DDVHAFGKA-YVQKGGFI-----K-G--IE-EFDNSLYGINDY-EASQMDPQQRLLLDCTFMALEDAGFTR--------KQLSG--SKTGVYI---------------------------------------G-SMNADH--RSSS-AA-----------I----S--S-NIGSYTASSSANSFLSGRLSYVFNLLGPS------VMIDTACSSSLIAIHLGCQAIHAGDCDQAICGGVNCMLLP-DVFVHLSKARMISPSGLCHTFSDKAD--------------------------------------------------------------------GYTRGEGCGIVILKRLT-D--------------A--LRDGDQVWA-TIS-TGTN--QDGRTVT-------P---VTAPSGEQQKKLLKDVYDK-Y-PVDL-SQLEYIEAHG-----------------------------------------------------------------------T-GTPT------G------DPVEVNAVG-SFLK-ES---G----H------------------------------------------------------------L-----R-QRYIGSVKTN-IGHTESAAGALSVIKLCLMMKNNAIVPSLH-C---E--V--VNPNIN-ITDFKLLIPK--APV-PWLT--P-------EKLTCCSSFG-FGGSNCHAILQSVR----RE--------------------------------------------------------------------------P-------------------- 377 ------------------------VAIVGIGCRTP-G-A---DNIRDFWRVLV-NGECHV-TDVP-D--D-RW-NASA--YLDT---EDRMAYGKA-YVQKGGFI-----K-D--IG-AFDNGLYGINDL-EASKMDLQQCLLLDCTMMALQDAGITR--------QEIAG--SNTGVFV---------------------------------------G-AMNCDC--TSGF-IG-----------C----T--S-KVDSYTATNVGTCIMANRLSHVFDLRGPS------MVLDTACSASLVAIHMGCQAILTGDCDMAICGGVNVMTLP-DMLVHLSKAGMISPTGLCHTFSKNAD--------------------------------------------------------------------GYTRGEGCGVVILKRLK-S--------------V--EQKGDSVWA-AIS-TGTN--QDGRQEK-------L---LTNPSGYQQKKLLESVYRK-F-DVNI-ENVDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEANALG-SFFK-EH---G----R------------------------------------------------------------P-----R-DRYIGSVKTN-IGHTESAAGVLSIIKVLLMMKHGKIVPSLH-CR-ED--E--VNPAID-LIDLKFKIPR--SAI-PWDT--D-------TKVAGCNSFG-FGGSNCHAVLTSVR----KN--D------------D------DQP-R-------------KVR-----L-SVNFTDTHFLVCFSGKTTESL---R-------------------- 378 ------------------------IAIVGIGCRTP-G-A---DNIRDFWRVLV-NGECHV-SDVP-E--D-RW-NSTA--YLDT---EDRMAYGKA-YVQKGGFM-----K-E--IG-AFDNTLYGINDL-EASKMDPQQCLLLDCTMMALQDAGITR--------QEIAG--SNTGVFV---------------------------------------G-AMNCDA--NGDF-TG-----------C----T--S-KVDNYTATDIGMSIIANRVSHVFDLRGPS------MVVDTACSASLVALHLGCQAILSGDCDMAICGGVNVMTLP-DMFIHLSKAGMISPTGLCHTFSKNAD--------------------------------------------------------------------GYTRGEGCGVVILKRLS-N--------------V--QQKSDKLWA-TVS-TGTN--QDGRVEK-------L---ITNPSGAQQKKLLKDVYSK-F-GINI-ETVDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEANALG-SFFK-EH---G----S------------------------------------------------------------P-----R-DRYIGSVKTN-IGHTESAAGVLSIIKILLMMKHGKIVPSLH-CS-TD--E--VNPAID-LTGLRLKIPQ--AAV-PWDT--E-------DKTAVCNSFG-FGGSNSHAVLQSVR----KR--T-------------------------------------------------------------AQEKEPV---S-------------------- 379 ------------------------------------------------WDILA-KGENHV-VDIP-P--E-RW-NMDA--FFD----SDVNAVGKS-YATKAGLL-----K-N--FD-HFDNKLFKINET-EAAQMDPQQRQVLECTYMALEDAGITR--------QQIAG--QKVGVFL---------------------------------------G-CMNNDF--TQLA-NK-----------Y----P--H-LVDNFTVTGTGNSIVSNRVSYAFDLRGPS------MTIDTACSSSLVAIHQAGLAMKEGDCSMAICGGVNLLLSG-GVFVPLSKAQMLSPTGQCHAFSANAD--------------------------------------------------------------------GYTRGEGCGIVIIKPFK-Q--------------A--LEDGDNIWG-TLV-TGLN--QDGHVAK-------P---LTAPSGEQQAQLIQDVYTK-H-GIDP-ASIDYIEAHG-----------------------------------------------------------------------T-GTKI------G------DPVEVKAFG-DFFL-QQ--QQ-S--K------------------------------------------------------------R--------RYIGSVKTN-IGHLEAAAGVAGLIKVLLMMNHSTIVPSLH-FD-MP------NEEID-FDKFQFDVPT--KTV-QWLP--D-------QKVACLNSFG-FGGANSHALVKSI------------------------------------------------------------------------------------------------------ 380 ----------------------------------------------------------------------------------------------------------------N--VE-SFDNTLYGINDY-EATQMDPQQFLLLDCTSMALEDGGFTR--------KQMSG--TNTGVFI---------------------------------------G-AMNNDY--TGAY-YG-----------H----T--S-KVNTYTGTGISNAILASRVSYVFDLRGPC------LVVDTACSASLVAIHQACLAIRSGDCDVAICGGVNCILSP-DMYIKLSKARMISPTGLCHTFSEDAD--------------------------------------------------------------------GYARGEGCGIVILKRLK-D--------------A--ERDRNKVWA-TIN-SGTN--QDGRSVT-------P---MTAPSGEQQKKLLHAIYSK-W-QVDI-SQLDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEVNALG-SFLK-ER---G-S--P------------------------------------------------------------P-----R-SRYIGSVKTN-IGHTESAAGVLSLIKILLMMKHNTIVPSLH-C---Q--K--VNPKID-LQNWKFIIPK--ELV-SWDS--P-------NKLAACNSFG-FGGSNAHVVVYYFP----ST--Q-S----------A------Q-E-PASS----------SSR-----N-------KLSIVCFSGKTQKGL---K-------------------- 381 ------------------------IAIVGIGCRTP-G-A---DNIQDFWRLLR-NGECHI-SDVP-A--D-RW-NAAA--FLD----ADPSAPGKA-YVQKGGFI-----K-D--VE-GFDNVLYGINEF-EASQMDPQQCLLLDCTTMALQDAGITT--------TNLAN--SNTGVFV---------------------------------------G-SMNNDH--VFKF-IG-----------K----S--S-KIDNYTATGVSTTILASRLSYVFNLTGPC------MVLDTACSASLVAVHQGCLAIRSGDCDMAICGGASCMMTP-DMFISLSKARMISPSGLCHSFSDQAD--------------------------------------------------------------------GYTRGEGCGVVILKRLE-D--------------A--IKDGDNIRA-VVY-SGTN--QDGHAVT-------P---MTAPSGEQQKKLLRFVYNK-H-KINV-DEVDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEVNSLG-SFFQ-EN---G----S------------------------------------------------------------T-----R-ERHIGSVKTN-IGHTESAAGVLSLIKVLLMMEHDMIVPSLH-C---Q--V--VNPRID-LPGYRFVIPQ--DP---------------------------------------------------------------------------------------------------------------------------------------------- 382 ------------------------VVITGISCRLP-E-S--D-NMEEFRQHLL-LGEDMV-TE---DNR--RW-EPGY--------------L--G-LPKRNGKLK--------DLSK-FDATFFGVHPK-QANAMDPQLRMLLEVTYEAIIDSGYSP--------QDVRGS--KTGVFI---------------------------------------G-VSASEA--GEAW-AS---N------------P--E-TVVGYSMTGCCRAMFANRLSYFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLLALDQALASIRSGNCDSAIVGGSNICIKPTTAQQFLKLGMLSPD-GTCKSFDASGDGYCRSEAIVAIHIQKLP-V--------------A--RR----IYS-TLVHAKNN--ADGNKEQ-------G---ITYPSGEVQKSLLKQTYKE-A-NIDP-CQVAYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNSIV-DVFT-K--G---R----------------------------------------------------------------R----G-PLLIGSIKSN-MGHPEPASGLAAIAKVIVAMEEGIIPANLH-F---T--E--PNPDIPGLLDGRIKVVS--EGT-KWNG-----------GYVGVNSFG-FGGANVHAILKSN----DSK--P-Q------R----RHP--AS-K-------------------------L------RRLCLYSGRTEESVNRAL-------------------- 383 ------------------------VTISGISGRMP-E-S--S-NMEEFEKHLM-DKEDMV-TA---DDR--RW-KM-------------GL-H--G-MPTRNGKLK--------ELQH-FDAGFFGVHPK-QANCMDPQLRMLLEVCYEAIIDSGQTL--------NSVRGS--KTGVYV---------------------------------------G-VSTSES--SEAW-SA---D------------A--E-TLVGYSMPGCCRAMFANRISFFFDFKGP------S--------------------------------------------------------------------YSVDTACSSSMICLDHALQNIRMGIIDSAIVGGTNLCLKANTSLQFVRMGMVAPD-GACKTFDDSANGYCRSEAVMAIFLQKSA-D--------------C--KR----IYA-SVLHTKSN--SDGYKEQ-------G---ITFPSGQLQKQLINEVYHE-I-GIKP-QDISYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINTIV-DVFC-K--G---R----------------------------------------------------------------K----D-PLLIGSTKSN-MGHPEAASGLTSIAKILIAMEKQVIPPNLH-F---K--S--PNPEIPGLTDGSLQVVS--EKT-QWNG-----------GLVAMNSFG-FGGSNVHAIFKSH--E--KE--Q-S------A----PHV--AS-K-------------------------K------PRLFTFSARTKEGVQAVL-------------------- 384 ------------------------VAISGISGRMP-E-S--S-NMEEYEQHLM-NKEDMV-TA---DDR--RW-EI-------------GL-H--G-LPPRSGKLK--------ELRH-FDAGFFGVHPK-QADNMDPQLRNLLEVSYEAIIDSGQTL--------ESIGGS--KTGVFV---------------------------------------G-VSLTES--SEAF-SK---D------------A--E-NLIGYGMAGCAKSMFANRISFFFDLKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQAVLNIKTGLIDAAIVAGCNICVKPTSSLQFLRMGMLSPE-GACKSFDAAGNGYCRSEAVVAIFLQKSA-D--------------C--KR----IYT-TVVHTKSN--SDGYKEQ-------G---ITFPSGKLQKKLINELYHE-I-GLNP-LDVFYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQETNTIV-DVFC-K--G---R----------------------------------------------------------------K----D-PLPIGSTKSN-MGHPEAASGMTSIAKIIIAMERQVIPPNLH-Y---N------------------------------------------------------------------------------------------------------------------------------------------------------------------------ 385 ------------------------ICITGMSGRVGQ-A----RNLEDFKDLLW-NKKHAF-T--E-E--YSRF-DCD---KF-------------G-TQKRHAYIN--------DIDK-FDSKYFDIDPK-NANFLDPNIRLGLEATYEAIIDAGYSV--------EEVRGS--VTGVYV----------------------------------------SCVAYDA--NYFW-GG---K------------SIDE-FGEKS--MGIHNSFRASQVAHAFDLRGPN------SVVDAACSGYLAAMELAMKDIRLGHCDRAIVLATQLHTNP-MAENLFLSIGAAGPNGICYAFDERAE--------------------------------------------------------------------GLARGEAVGAMFLQKEE-D----------------ARR----VWSK-LVHAYQS--ADGNSGD---------FDFNRPAPIGQMANMSECYRQ-A-NIDP-QTIDFVECHG-----------------------------------------------------------------------T-GTSA------------GDGTEATAIS-GVFL-GD-R---R----------------------------------------------------------------K----N-VLTIGSVKTY-VGHAEAAAGFNACVKCALGLNEGVIVPNIN-YE-----R--PNPNIAALVDGRMRVVT--EVT-PYPG--E---------MVGINGFG-LGGTDAHIILKKND----RP--N-K------T---V-HP--AR-E-------------------------A------PRLFTYGARTEEGLKNII-------------------- 386 ------------------------VSISGISGRMP-E-S--S-NMQEFRDHLM-NKEDMV-TA---DNR--RW-EV-------------GL-Y--G-VPARNGKLK--------EITT-FDAGFFGVHPK-QADCMDPQLRMLLEVSYEAIVDSGQTM--------QSVRGS--KTGVFI---------------------------------------G-VSIAEA--SEVW-SA---D------------P--E-TLVGYSMPGCCKAMFANRISFFFDFTGP------S--------------------------------------------------------------------YSVDTACSSSMMCLDQALMNIRMGIIDSALVGGTNLCLKTQTSLQFTRMGMTAPD-GTCKAFDVAGDGYCRSEAVMAVFLQKSK-D--------------C--KR----IYA-TVVHTKSN--SDGFKEQ-------G---ITFPSGALQKALIKDVYYD-I-GLNP-KDIAYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINSIV-DVFC-K--D---R----------------------------------------------------------------E----T-PLLIGSTKTN-MGHPEAASGLTSIAKIIIAMEERTIPPNLH-Y---Y--S--PNLEIPGLSDGSLKVVT--EPT-PWNG-----------GLVSMNSFG-FGGSNVHAIYRSF--D--KE--Q-S------E----PHM--AS-D-------------------------K------PRLFTFSARTEEGVRAVL-------------------- 387 ------------------------ICITGMSGRVGQ-C----RDMEEFKEMLL-NKKDAF-T--D-K--PMRY-NTD---KY-------------N-KQKEHAFME--------DTEK-FDSDYFGIAPK-NAEYLDPHIRLNLEAAYEAIIDAGYSM--------SEVRGT--VTGVYV----------------------------------------AAAHYDS--LVYW-QN---V------------GIKN-HADASKGLGAITNFRATRISYCMDLRGPS------YVVDTACSGYLSSIDAAIKDIRLGNCSQAIVASTHLHCNP-LSSESLFEKGLLGENSRCFSFDEKAE--------------------------------------------------------------------GFARGEACGVLFLQKEE-D----------------SRR----IHAK-LVHSFQN--ADGNIGG---------LDFNSPCFDGQVNALKACYRE-A-NIDP-QKIEFVETHG-----------------------------------------------------------------------V-GVKE------------WDTTEANAIT-EVFC-GK-K---R----------------------------------------------------------------A----K-PLMVGSVKTN-VGHAEATTGFSSIAKCVMGMKEGVILPNIN-FE-----K--PNMEIPGLHDGRLKVPT--EVT-PWNG--E---------MCGINAYS-FGGNNVHVILKKND----KP--N-K------K---T-DH-PAS-R-------------------------S------PRIFTYCARTEAGLQNIL-------------------- 388 ------------------------ICITGMSGRVGQ-C----KNLDEFKDMLM-KGKDAF-T--D-K--SMRF-DID---KY-------------G-TQKEHAYFE--------EAEK-FDNDYFGIAPK-NAEFMDPNIRLSMEAAYEAVVDAGYSM--------HEVRGT--LTGVYA----------------------------------------SVVTLDA--SNYW-LS---K------------TLDA-ITEASKGLGVIHNFRASRVSYSLDLRGPS------MCVDTACAGYLSAIEAAIKDIRLGNCDQALVVTSQLEANP-LSEQHFMDLGLSGPNSKCFSFDERAE--------------------------------------------------------------------GFARGEAMGAIMLHKEE-D----------------ARR----IYAK-VAHGFQS--CDGSSGN--------TLDFSTPSFYGQIDTLKECYRQ-A-GVDP-QTIEFVECHG-----------------------------------------------------------------------L-GTKI------------GDTTEVNAIT-EVFC-GQ-R---R----------------------------------------------------------------T----K-PLMIGSVKPN-VGHAEAAAGFNSTIKCVLALNEGVIPPNIN-FE-----K--PNKDIPALHDGRLKVPV--EPT-PFSG--D---------KCGISAYS-FGGTNTHLILKKND----RP--N-K------K---E-HP--AS-Q-------------------------S------PRLFTYGARTEEGLQNIM-------------------- 389 -----------------------------MSGRIGQ-C----KNLDEFKDILM-KGEHAF-T--D-K--SMRF-DID---KY-------------G-TQKEHAYFD--------DADK-FDNDYFGIAPK-NAEFMDPNIRLSMEASYEAVVDAGYSM--------TEVRGT--HTGVYA----------------------------------------SIVTLDA--GNYW-LS---K------------SIDA-IQEARLGLGVIQNFRASRVSYAMDLRGPS------MCVDTGCAGYLSAIEAAMKDIRLGNCEQAIIVTCQLEANP-ITEQHFMDQGLSGPNSRCFTFDERAE--------------------------------------------------------------------GFARGEALGAIFLQKEE-D----------------ARR----VYAK-VVHGYQS--CDGNSG----------VEFSTPSFIGQIDTLKECYRQ-A-GVDP-QTIEFVECHG-----------------------------------------------------------------------L-GTKV------------GDTAEANAIA-EVFC-GK-Q---R----------------------------------------------------------------T----K-PLMIGSVKTN-VGHAEAAAGFNSTVKCVIGMNEGVVPPNVN-FE-----K--PNKEIPGLHDGRLKVPV--EPT-PWSG--E---------MCGISAYG-YGGSNIHVILKKND----RP--N-K------I---E-HP--AS-Q-------------------------S------IRLFTYGARTEEGLRNII-------------------- 390 ------------------------ICITGMSGKVGQ-A----NNMDEFKEMLW-NKKNAF-T--N-T--ALRF-DFD---KY-------------N-TQKWFAYIN--------DAEK-FDNEFFGIDKK-KAAYIDPNIRLSIEAAYEAIVDAGYSL--------EEVSGT--KTGVYA----------------------------------------PCVGYDA--SNYW-HG---K------------GVDE-FGEGS--LGVHNSFRASRISYEMDLRGPS------MAIDTACSGYMAAVECALKDIRLGICDQAIIAGSQLHCNP-IAAMLFLDIKAAGPNCICYAFDERAE--------------------------------------------------------------------GMSRGEAVGSLFIQKAE-D----------------ARR----IHTK-VAHAYQS--CDGNSGD---------FDFNHPSVEGQMATIATCYKQ-S-GVDP-HKITFVECHG-----------------------------------------------------------------------T-GTVA------------GDSTEVNAID-NIFC-GE-R---R----------------------------------------------------------------T----E-PLMIGSVKTN-MGHAEAVAGFNAIAKCIFSFYESTIPPNIN-FE-----R--PNKSIPGLLDGRLKVPV--ELT-PWDG--T---------LCGISGFG-LGGTSSHMVLKKHV----AT--N-V------T---D-HP--AS-E-------------------------F------PRLFTYCARTEEGLNNIL-------------------- 391 ------------------------ICITGMSGRVGQ-A----RDLDAYKDVLW-NKKSAF-T--D-K--HLRY-DID---KY-------------K-TQRLWSYIN--------DADK-FDNEFFDIEQT-KANYLDPNIRLAIEAAYEAIVDAGYSK--------EEVAGT--RTAVYA----------------------------------------PCVDYDA--SNFW-ST---K------------GTEE-FGEGS--LGVQNSFRASRISYQFDLRGPS------VAMDTACSGSISAIECAMKDIRLGNCDQAIIAGSQLLCSP-YSAKMFFDIGAASKQCICYAFDERAE--------------------------------------------------------------------GMSRGEAIGTMFIQKAE-D----------------ARR----IHAK-VVHNHQG--SDGNSGD---------FDFNHPSIPGQTAVIRRCYEQ-A-GIDPQTEIDYVECHG-----------------------------------------------------------------------T-GTVA------------GDSTEVNAIA-NVFC-GD-R---R----------------------------------------------------------------T----I-PLMVGSVKPN-MGHTQGAAGFTSIVKCIWSFYESCIPPQIN-FE-----K--PNRTVPCLLDGRIKVPT--VHT-PWET--K---------MCGVSGFG-IGGTDSHIILKKSD----VQ--D-E------V---M-HP--AN-E-------------------------A------HRLFTYGARTEEGLKTIL-------------------- 392 ------------------------VVITGISCRLP-E-S--D-NMEEFRYNLA-NGVDMV-TE---DNR--RW-EPGY--------------L--G-LPKRMGKLK--------DLTK-FDAPFFGVHPK-QANAMDPQLRMLLEVTYEALVDSGFDP--------QTLRGS--KTGVFI---------------------------------------G-VSASEA--AEAW-SN---N------------P--E-TLVGYSMTGCCRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLLAMDQAMTSIRMGYCDSAIVGGSNICIKPTTAQQFLKLSMLSPD-GTCKSFDATGNGYCRSEGIVAIHLQKAS-V--------------A--RR----IYS-TVVHSKNN--ADGSKEQ-------G---ITFPSGAIQKQLLLETYQE-A-KVDP-SQVAYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINSIV-DVFC-K--D---R----------------------------------------------------------------T----G-PLMIGSTKSN-MGHPEPASGLAAVAKVIIAMEDKLLPGNLH-Y---N--E--PNPDIPGLLDGRLKVIT--QQT-RFEG-----------GYVGVNSFG-FGGANVHAILKSN----SNE--K-T------V----PHP--SA-S-------------------------A------RRLCLYAGRSEESVTTML-------------------- 393 --------------------------------------------------------IEVV-TP---TD--IRF-PSG-------------E-L--D-LPPDMGIIY--------DADK-FDAEMFHFTRE-MAKATDPKMRMLLESTYEALADAGETM--------QSVKGT--RTGVYV---------------------------------------G-TLGLDY--QDT--LT----------------A--E-RITGSSYIGNNMAYLSQWISHAFDLKGP------S--------------------------------------------------------------------ITLDSACSSSSMALSQAVLNIRRGHIDAAIVGGSTMIMDPFASKVIDLSSAMSPE-GRCKTFDASANGYARSEGVLIFYVTKES-L--------------A--KR----IYT-TVLSIRGN--SDGYKPM-------S---MASPSRAAQMKLMQEVIDG-A-GIDK-AKITLAEAHG-----------------------------------------------------------------------T-GTIA------------GDGQEADGIA-EILCSV------E---------------------------------------------------------------RD----Q-PLLISSVKSC-VGHTEGAAGLASMCKVIFGMENELIPPNLH-F---N--D--PNPIIQCLNDGRAKVVS--EPT-PWKG----------HVLATVSAFG-IGGSNYIACLRSH--K--KK--M-A------A---P-HP--AS-K-------------------------V------PRVVCYCARSEEAAERVL-------------------- 394 ------------------------------------------------------------------------------------------------------------------------------------------------------IVDAGQTM--------ESVRGS--RTGVFV---------------------------------------G-VSLSDA--SEAW-TV---D------------A--E-KTVGYTMPGCCRAMFANRVSFFFDFKGP------S--------------------------------------------------------------------YALDTACSSSMTCLDQAMLSIRSGLIDSALVGGTNLCLKPNTSLQFTRMAMTSPD-GACKTFDASANGYCRSEAIMAIFLQKSA-D--------------C--RR----IYV-TIAHSKSN--SDGYKEQ-------G---VTFPSGIAQQTLINEVYHE-I-GISP-TEISYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINTIV-DVFC-K--G---R----------------------------------------------------------------K----E-PLLIGSTKSN-MGHPEAPSGITSMAKVIIASEERMMPPNLH-F---N--N--PNPEIPGLTDGSLKVVT--ECM-PWNG-----------GLVAMNSFG-FGGSNVHVLVRTY------------------------------------------------------------------------------------------------------ 395 ------------------------IAIVGVGCKFP-G-A---DNVDEYWKLLY-DGENHV-EEIP-K--K-CF-NLDA--YYD----PDPNVLGKC-YSRRAGLL-----K-N--PL-DFDNKLFKISDR-EADSMNPEQRHVLECSYMAMQDAGITQ--------QELFG--SKTGVYL---------------------------------------G-VMNNDY--SNLL-DA-----------R----T--C-RPSNYTVTGTHRSIVANRLSYVFDLRGPS------QTIDTACSASLCAIDSGIQAIRAGQCDMAFCGGVSSILSP-EAFIHLSKARMLSPTGACKVFTDDVD--------------------------------------------------------------------GYTRGEGCGVVILKRLS-D--------------A--QNHGDHIWA-IID-SGSN--QDGRGAT-------P---ITSPSGEQQKKLLEDVYAK-S-EVNA-RDIQYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPVEANALG-QFFL-QS--NG-D--Q------------------------------------------------------------K-----PPLRYVGSVKTN-LGHLESAAGVAGLIKVLLMMKHSTIAPTLF-FK-SP------NPKIR-FEDYKLKVPT--ENL-PWEN--E-------NKVACVNSFG-FGGTNCHVVLLSYA----KE--K-N------P---V-H----K-R-S-----------------------S------ASIVIFSGRDEKSLK--K-------------------- 396 ------------------------LVITGISCRLP-E-S--D-NMEEFRQHLL-LREDMV-TE---DNR--RW-EPGY--------------L--G-LPKRNGKLK--------DLSK-FDAVFFGVHPK-QANAMDPQLRMLLEVTYEAIVDSGYSP--------QTLRGS--KTGVFI---------------------------------------G-VSASEA--AEAW-SA---D------------P--E-TLVGYSMTGCCRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLLALDQAISSIRSGNCDSAIVGGSNLCIKPTTALQFQKLGMLSPD-GMCKSFDASGNGYCRSEGVVAILIQKKS-S--------------A--HR----IYS-TLVHSKNN--ADGSKEQ-------G---ITFPSGAVQKTLLEETYSE-A-GIDP-SSVAYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNTIA-DVFC-Q--D---R----------------------------------------------------------------Q----Q-PLLIGSVKSN-MGHPEPASGLAAVAKVIIAMEDKLLPANLH-F---E--E--PNPDIPGLANGKLKVVT--EST-RWSG-----------GYVGVNSFG-FGGANVHTILKSN----DIE--K-T------S----QHP--AS-R-------------------------S------SRLCIYGGRSEEAVEHML-------------------- 397 ------------------------IAIIGIGCRFP-G-A---ANLTEYWRVLS-DGENHI-TTVP-P--D-RW-AEKD--FYD----ENPDAVGKS-YINKAGFI-----P-G--FA-DFDNKLFRISET-EALQMDPQQRQVLECTYMALENAGITR--------EQISG--KKVGVYI---------------------------------------G-SMNTDY--NMLT-VS-----------F----D--E-KVDPYSVAGLATSVIANRMSYQFNLTGPS------MSIDTACSSSLVAIHQAILGLRAGDCSQAICGGVNFIAHP-QVFDALSKARMLSPTGQCHTFSNDAD--------------------------------------------------------------------GYTRGEGCGIVVLKPLD-Q--------------A--ISDGDDIWG-TIS-TGLN--QDGHCAQ-------P---ITAPSQQQQEDLLKEVFTR-H-QIDP-GTVQYIEGHG-----------------------------------------------------------------------T-GTKR------G------DPIEIGAFS-SFFS-NH--GQ-P--R------------------------------------------------------------Q--------RYIGSAKTN-IGHLEPAAGVAGLIKVLLMMK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 398 -----------------------------------------------------------------------RY-ENG-------------L-Y--G-NQENMGIMP--------DVDK-FDASFFGMYPS-MVVATDTSVRHLLERCYEAIVDAGESH--------DTMKGT--RTAVFV---------------------------------------G-ALCSDS--DEWA-RT----------------E--D-RVNGYSFIGYAHCHMANRISYSFDLYGP------S--------------------------------------------------------------------ISLNSGCSSSMAAMELAVKQLRMGYVDRAIVAGTNLPLDPLLTLTATTDGALSPD-GKCRAFDANANGFVKSDGCVAVMLSRQS-L--------------A--KR----IYC-TLLHIRGN--NDGNSPD-------G---MTMPHEEAQVDLLKSVYED-C-NINP-NHVYYTETHH-----------------------------------------------------------------------R-GSAW------------ADEVEVAAID-KVLCSE------R---------------------------------------------------------------GRRGDYP-ALHIGTVKSN-MGDCEGASGFASLAKVIISMENQKIPANLH-F---E--T--PNLRMQALTEGRVKVVN--EHT-DFRF-----------GLASINSLG-IGGTNYHALFRSH--K--NE--S-R------A---A-HP--AS-D-------------------------C------PRLFVYGSRSE--------------------------- 399 ------------------------IAISGISGRMP-E-S--L-NMDEFKEHLM-NKEDMV-TA---DNR--RW-EM-------------GL-H--G-MPTRNGKLK--------ELRH-FDAGFFGVHPK-QADCMDPMLRMLLESSYEAIIDAGQSL--------QSVRGT--RTGVYI---------------------------------------G-VSSSES--SEAW-ST---D------------P--E-TLVGYSMPGCCRAMFANRISFFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALLNIRMGQIDSAIVGGCNLCLKAQTSLQFVRMGMVAPD-GACKTFDASGDGYCRSEAVMAMFLQKSP-D--------------C--KR----IYA-TVCHAKTN--SDGYKEQ-------G---ITFPSGIIQKRLIQEVYHE-I-GINP-IDVSYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEMNTIV-DVFC-K--N---R----------------------------------------------------------------K----T-PLLIGSTKSN-MGHPEAASGLTSIAKIIIAMENKMIPPNLH-F---K--T--PNPEIPGLSDGSLKVVD--ECT-RWDG-----------GIVAMNSFG-FGGSNVHAIYRSN--N--IE--A-S----DRE----QHM--AS-L-------------------------K------PRLFCCSARTEEGVKSIL-------------------- 400 --------------------------IVGIGLRLPGN-I---FNLCTLAETLE-NKRSCL-K--S-T----RW-KNG---LYG--------------MNHQCGKID---------VA-SISQSKYTLPL-AEVTELNPMISSLIEVVTESILDSGLKL--------FEVSEV--TTGLYM---------------------------------------G-ITFCDT--DCL-VT---------------------S--DSNSNCLNTRSQLTNLLANHFDLHGPV------IQFDGACASSFAALQAAVLDLKARRCDLAIVAGSNLVLDP-TVSLQFAKMNMLSPTGQSCPFDADAN--------------------------------------------------------------------GYVRSEGIAALILQLPD-K--------------RISRR----YYCD-VVGYDLR--SEGTKAE-------G---IIHPCVLSQSEMLGHVYE-K-FEIDM-NLIDFYEAHG-----------------------------------------------------------------------T-STQK------G------DLVELTAIS-EAIC-SK--R------------------------------------------------------------------A-----Q-PLYIGSIKGN-IGHTEATAGIAGILKCVASMLFGKVYPNIN-FH-----K--PNPNIPALKSDKLFVQT--DVD-YLSL----D----TPTITSVSSFG-FGGLIGHVVLHRN------------------------------------------------------------------------------------------------------ 401 ------------------------VVVSGFAGRFP-D-C---DNIKEFRDKLM-AKEDLL-VE---DDR--RW-KAGL--------------Y--G-LSKRAGKLK--------DIEL-FDAEFFDVCGK-EADNMGPDNRMLLETCYEAIVDAGLTM--------DMMKGS--RTGVFV---------------------------------------G-ISYCES--HDGL-TS---N------------A--E-IVTPYTMMGCCRANSANRIANFFDLKGP------C--------------------------------------------------------------------FTVDTACSAVPIAWDQALFNIRMGTIDSAFVCGTNLAMRVNSALQFLKMGMSSKE-GICKVFDAKGNGYARSETVGAVLLQKAE-D--------------C--RR----IYA-TMVHCKSA--NDGFKKL-------G---ITYPSGEEQKRLELEVVNE-A-GIDP-TLVQFVEAHG-----------------------------------------------------------------------T-GTKA------------GDPEEVNAFT-DVYC-P--G---R----------------------------------------------------------------K----E-PLLIASVKSN-MGHAESSSGIGSFAKILIAMEERVIPPNIH-Y---E--E--PNPDITGLMDGRLKVIT--EPT-KWNG-----------GYVAMNSSG-FGGANVHTLFKSY--D--KE--L-T------E----PHV--AS-K-------------------------K------TRLFTCCARTEEGVKAVL-------------------- 402 ------------------------VAISGISGRLP-E-S--D-NIAEFRDHLM-NKEDMV-TA---DNR--RW-EI-------------GL-H--G-LPPRCGKVK--------ELRH-FDAGFFGVHPK-QANCMDPQLRMLLEVSYEAIIDAGQTM--------ESVRGS--RTGVFV---------------------------------------G-VSLSDA--SDAW-TA---D------------T--E-TMVGYTMPGCCRAMFANRISFFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALLNIRMGVIDSALVGGTNLCLKPNTSLQFVRMGMTSPD-GACKTFDASGDGYCRSESIMAIFLQKAA-D--------------C--KR----IYA-TVVHTKTN--SDGYKEQ-------G---ITFPSGELQKQLVNEVYHE-I-GISP-LDIAYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINSVV-DVFC-K--G---K----------------------------------------------------------------K----E-PLLIGSTKSN-MGHPEAASGLTSIAKIIIAMEERVIPPNLH-Y---K--T--PNPDIPGLVDGSLHVVT--ECT-KWNG-----------GLVAMNSFG-FGGSNVHAIYRSH--D--KE--L-T------E----PHV--AS-Q-------------------------K------PRLFTCSARTEEGVKTLL-------------------- 403 ----------------------------------------------------------------------------------------------------------------------------------------EPLFRS-LERVYEAIVDAGESM--------DSMKGT--RTGVFF---------------------------------------G-GLPTDS--DECV-RN----------------V--E-RMNGYSFIGYTFCHLSNRLSYNFDFKGP------S--------------------------------------------------------------------FSLDSACSSGLAALEVALLQLRMNYLDYALVVSNNLVLDPLASLTAVKVGMLCLD-GKCKAFDAGANGFGRAEGNVALLLTKKE-L--------------A--KR----VYC-TILHVRGN--NDGFTKD-------G---IAVPSADSQSQLLRTVYTD-M-GIDP-NLVHYAEAHG-----------------------------------------------------------------------P-GTPV------------GDGIEVDAIA-DVLCTN------R---------------------------------------------------------------Q-----S-PLLLGSVKTN-FGHCEGTAGLASIIKTIILMENELIPTNLH-F---E--T--PNPNIKSLFDGRVKVVT--EET-PFKG-----------GLVSVSSFG-VGGTNYNGAFRT------------------------------------------------------------------------------------------------------- 404 ------------------------IAIIGVGCRFP-G-A---DNLDEFWRVLL-NGENHV-IDIP-P--E-RF-NLGA--FYD----ADENAPGKT-HVKKAGFV-----L-G--HD-EWENRLFKINNL-EALHVDPQQTFALECTFMALENAGIPR--------SKIAG--TNTGVYI---------------------------------------G-VTSEDY--QSLH-ST-----------E----S----EMNNYTLTGVSVTNVAARVSYVFDLRGNS------LTLNTACSSSLVAVHLGCQALKTGDCDIAICGGVNCILQP-GTFIRLSKTRMASPTGQCQAFSANAD--------------------------------------------------------------------GYARGEGCGIIILKKTE-N--------------A--KHDGDNIWG-TIF-TGVN--QDGQTVT-------P---ITAPSWKQQKRLFTDVYRK-N-AIDP-SSVEYIEAHG-----------------------------------------------------------------------T-GTKT------G------DHREVQSLG-EFFL-----------------------------------------------------------------DS-SN--S-----K-RRLIGSVKTN-IGHLESAAGIAGVIKVLLMMKYNKIVPSLH-FN-----T--PNPRID-FIRYNLEVAT--VVT-DWLT---------PRKFASVNSFG-FGGTNCHAVLGSPE----VP--Q-T------E---T-SA--RR--KDT--NRP-------------------------HIICFSGNTKESVL--K-------------------- 405 --------------------------------------------MDEFWRVLV-NGENHV-VDIP-S--D-RW-NLEA--FYD----ADGDAPHKT-YVRKAGFV-----R-G--HD-EWDSRLFQISDL-EASRMDPQQKFALECTFMALENAGIPR--------SKIAG--TNAGVYI---------------------------------------G-VMNTDY--KDLY-TT-----------E----S----EMNNYTLTGTSGGNVAARISYVFDLRGNS------LTVNTACSSSLVAVHMACQALRAGECDVAICGGVNCLLEP-GVFIQLSKARMASPSGRCQAFSADAD--------------------------------------------------------------------GYARGEGCGIIILKKME-D--------------A--RHDDDHVWG-SIF-TGVN--QDGHTVT-------P---MTAPSWKQQKVLFTDVFRR-S-GINL-NSVEYVEAHG-----------------------------------------------------------------------T-GTRA------G------DPVEIRSLG-EFFL-----------------------------------------------------------------ES-NS--S-----K-RRLIGSVKTN-IGHLESAAGIAGVIKVLLMMKYNKIVPSLH-FN-----T--PNPRID-FNRYNLEVAT--GVT-DWLT---------PRKFACVNSFS-FGGTNSHAVLAS------------------------------------------------------------------------------------------------------- 406 ------------------------IAIVGVGCKFP-G-A---RNLTEFWRVLE-NGENHV-VEIP-K--E-RW-NLDA--FYS----PDPDTPGKT-YVRRAGLI-----M-D--HD-EWDNRVYGINDI-EAASVDPQQRFVLDSTFMALEDAGIPR--------RRIYG--SKTGVYL---------------------------------------G-VMNTDY--KVMF-TN-----------P----V--S-PADNYTITGTSPSIIAARLSYVFNLLGPC------LMVDTACSSSLVAIHLACQAIRSGDCEMAIAGGVNYLMHP-SVFIQLSRAKMVSPTGQCQAFSANAD--------------------------------------------------------------------GYARGEGCGIIVLKKLK-D--------------A--LRDGDNIWA-TIY-TACN--QDGQTVS-------P---ITAPSMTQQKNLLQEVYSK-C-GVSM-DDIDYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPVEMKSLG-ETFL-----------------------------------------------------------------EN-AC--P-----K-QRFIGSVKTN-IGHLESAAGIAGIIKVLLMMKHGKIVPSLH-FY-----P--PNPALA-FDRYGFNVPT--ANR-DWDS---------SLKISCVNSFG-FGGTNGHAVVKLFN----R---P-T----E-T---V-QK--PI---RN--KTP-------------------------EVFCISAIDNKSL---E-------------------- 407 ------------------------IAIVGIGCRFP-GDV---NSPAEFFDVIF-NGKDCL-TDIP-K--D-RW-NQDV--YFN----PDPHSLGTH-INKRGGFIK------N--ID-KFDNGFFKISPK-EVLNMDPQQRHLLEVTHEAFEDAGIVP--------EKLDG---DCGVYV---------------------------------------G-IGMMDY--ALMN-CA---N------------T--K-GFNAYAHTGMAHSVAANRISFALDLKGPS------LATDTACAASMTALHLACTGLWNQECKAAVVAGSNVLLMP-EVTCGFSALSVLSPESESRPFDANAK--------------------------------------------------------------------GYVRGEGFGAVIIKPLD-Q--------------A--IKDGDNIYC-SIIGSGIA--ANGLTP--------S---VTMPSKDAQVQLMKSVYKQ-Y-NINP-EQLLYVEAHG-----------------------------------------------------------------------T-GTPV------------GDPIEAEAIG-LALA-QG--R------------------------------------------------------------------E-----Q-PLRIGSGKSN-FGHLECCAGMISIIKTALMMKHRTLCPSIN-YI-S------PISPE--FNAWNIEVQK--KTE-LFPE--G------K-YLIGVNNYG-FGGALAHAVFQEVS----TH--C-T------K---V-IG--S----------------------------------------------------A-------------------- 408 -----------------------------------------------------------M-VEIP-K--E-RW-NLDA--FYS----SDPDAPGKT-YVRRAGLV-----M-D--HD-EWDNRLYNINDI-EAASVDPQQRFVLDSTFMALENAGIPR--------KRIFG--SKTGVYL---------------------------------------G-VMNNDF--KMMY-TN-----------P----I--S-PVDNYTVTGTSSSITAARVSYVFNLLGPC------LAVDTACSSSLVAVHLACQAIRAGDCEMAIAGGVNSLMHP-SVFIQLSRAKMASPTGQCQAFSANAD--------------------------------------------------------------------GYARGEGCGIIILKKLK-D--------------A--LRDGDNIWA-TVF-TGCN--QDGQTVS-------P---ITAPSVIQQQGLLREVYSK-Y-GVNM-DDIDYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPVEMKSLG-EIFL-----------------------------------------------------------------EK-AC--P-----K-QRFIGSVKTN-IGHLEAAAGIAGIIKVLLMMKHGKIVPSLH-FD-----P--PNPALA-FDKYSFNVPT--AVR-DWDS---------ASKISCVNSFS-FGGTNGHAVIKMFH----K---S-E----D-E---I-QE--AT---QN--TGP-------------------------HILCISASDNKTLE--S-------------------- 409 -------------------------------------------------------------------------------------------------------------------------------------AACNVHLRHLLPVIYECIVDSGLSP--------HILQDS--RTGFYF---------------------------------------A-TGDNDD--DAA-LV---------------------AEG-TCTNTSNLKSFFGAEIGRLFGLDGPV------LCVNTACSSSIAALHAALSDMHAGRWQYAIVAGTNLIINP-NMSLKFLRLTMLSPTGDSHVFDETAN--------------------------------------------------------------------GYVQSDGVAALLLARSE-S---------------DCAR----IYAT-IVDTIVM--SDGRKEE-------G---VLHPSDHNQALMLTTVYN-R-NRIDA-DDIAYIEAHG-----------------------------------------------------------------------T-GTRE------G------DRAEIEGLS-LAFF-RS--P------------------------------------------------------------------D-----T-RILIGSVKSN-VGHCETVSGLAGIIKCLLAMHHQTLPPNLH-FN-----I--PNSKLGYLLNKQFQVVT--QNT-PLPD----G-------LFGVNSFG-FGGVIGHVILK-------------------------------------------------------------------------------------------------------- 410 ------------------------IVISGISCRLP-E-S--D-NMEEFRQHLM-LGEDMV-TE---DDR--RW-EPGL--------------Y--G-LPRRSGKLK--------DISR-FDASFFGVHPK-QADAMDPQLRMLLEVTYEALVDAGANP--------L-ARGQ--KTGVFI---------------------------------------G-VSASEA--AEAW-ST---D------------P--E-TIVGYSMTGCCRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLLAMDHAILSIRMGHCDSAIVGGSNLCLKPSTALQFLKLGMLSPE-GSCKSFDASGNGYCRSEGVVAIYIQKAS-A--------------A--KR----MYS-TVIHSKNN--SDGAKEQ-------G---ITFPSGEIQKRLLREVYSE-A-CIDP-STISYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNSIV-DVFC-K--G---R----------------------------------------------------------------Q----G-PLLIGSTKSN-MGHPEPASGLSSIAKVIIAMEDGVIPANLH-Y---N--E--PNPDIPALVDGRLQVVS--EKI-KWNG-----------GYVGVNSFG-FGGANVHAVLKSN----LHE--K-T------K----VHS--GS-C-------------------------A------RRLFLYSARTEEGLRHVF-------------------- 411 --------------------------------RMP-GHV---NSADDFWNVIL-NGKDVL-REVP-S--D-RW-SLDA--YHN----PDPTSLGTH-VNKRGGFIS------D--MD-QFDNGFFKISPK-EAAMMDPQQRHLLEVTHEAFEDSGIIP--------ENLQE---NCGVYV---------------------------------------G-IGMMDY--PLML-GP---D------------S--R-NFNAYAHTGVAHSVAANRISFAFNLKGPS------VAVDTACAASMTALHFGCQALWNKECNVSVVAGSNVLLMP-EVTAGFSALSVLSPNGESRPFDCNAK--------------------------------------------------------------------GYVRSEGFGAIIIKPLA-Q--------------A--VADGDNIYC-TVLGSGIA--SNGANL--------S---ITMPSCDAQLRLMQSVYDQ-F-KIDP-AKLLYVEAHG-----------------------------------------------------------------------T-GTPV------------GDPIEAEAIG-RALA-SE--R------------------------------------------------------------------K-----E-PLRIGSAKSN-FGHMECCAGLVSIIKVALMLKNRQLCPSIN-FT-K------PIDNR--FKEWNVEIQT--KVE-DFPA--D------KKYLIGVNNYG-FGGALAHAVLGEAS----IK--T-K------P---K-QT--NA-G-WK---FGSE-EE----T-----G-------KEFIIPFSAKTEEA----L-------------------- 412 ------------------------IAIVGVGCKFP-G-A---DDPEQLWRVIR-NGENHV-TEVP-P--D-RF-NKDA--FYD----TDERATGKA-YVRRAGFL-----K-D--PL-AFDNKLYNISDP-EADQMDPQQRMALDCSYRALEDAGLTR--------ERIKG--SNTGVYV---------------------------------------G-SMTTDY--RGTF-NA-----------R----T--D-LVGNYTATGFSSNIISNRVSYVYDLRGPS------VTVDTACSAALFAVDMAVKSLRSGDCDLAFCGGVNFMLSP-DVFVHLSKAKMLSPDGQSYAFSEKAN--------------------------------------------------------------------GYGRGEGCGIIILQKLS-D--------------A--LSEGNKVWA-VVD-TASN--QDGRTKS-------P---MPAPSGQQQKELLETVYKK-A-GVNP-DTVHYIEAHG-----------------------------------------------------------------------T-GTKM------G------DPIEARAVG-EFFK-QS--GT-S--R------------------------------------------------------------R--------RYIGSIKSN-IGHLESAAGIAGLIKVILMMKYSTIPRTLF-AD-TP------RKEID-FGKLNLIVTK--EEV-HWTE--S-------NKTACVNSFG-FGGTNCHAILQSR------------------------------------------------------------------------------------------------------ 413 ------------------------VAISGISGRMP-E-S--Q-NITEFQEHLM-KKENMV-TV---DDR--RW-KI-------------GL-N--G-LPPGNGKLK--------ELGH-FDAAFFGVHPK-QADCMDPQLRMLLEVCYEAIIDSGNSL--------ESIKGS--RTGVYV---------------------------------------G-VSTSDA--SDAW-TT---D------------A--E-TLVGYAMPGCCRAMFANRISFFFDLKGP------S--------------------------------------------------------------------FAVDTACSSSMYCLDQALLNIRMGLIDSALVGGTNLCMKPNTSLQFTRMGMTAPD-GHCKTFDAAGNGYCRSEAVMAVYLQKSA-D--------------C--KR----IYT-TVVHTKSN--CDGYKEQ-------G---ITFPSGNSQQTLVKEVYNE-I-GISP-LEVSYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINSLV-EVFC-K--G---R----------------------------------------------------------------P----E-PLLIGSTKSN-MGHPEAASGLTSIAKIIIAMESGILPPNLH-Y---N--T--PNPEIPALTDGRLKVIT--ECT-RWNG-----------GYVGLNSFG-FGGANVHALLRSY--D--KE--Q-T------S----PHV--SS-Q-------------------------K------TRLFTYGARTEEGLKAVL-------------------- 414 ------------------------IAIVGIGCRAP-G-A---DNIQEFWRVVQ-HGECHI-SDVP-T--D-RW-NAKA--FLD----PDPNAPGKA-YVQKGGFI-----K-D--VE-GFDNYLYGINDF-EASKMDPQQCLLLECTTMAMQDAGITS--------SQLSG--SNTAVYI---------------------------------------G-AMNNDY--GSTF-IG-----------K----T--S-KVDHYTATGISNTILASRLSYIFNLTGPC------MVLDTACSASLIAIHQGCLAIRSGDCDAAICGGVNCMLTP-DMFVHLSKARMVSPTGLCHTFSDQAD--------------------------------------------------------------------GYTRGEGCGIVILKRLT-E--------------A--MRDGDNIRA-IVC-TGTN--QDGHSVT-------P---MTAPSGEQQKKLLHSIYDK-F-QIDV-SQVDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEVNSLG-SFFK-EK---G----P------------------------------------------------------------P-----R-ERHIGSVKTN-IGHTESAAGVLGVIKVLLMMEHSLIVPSLH-C---D--V--ASPKLN-LPGHNFVVPQ--NLI-PWTR--P-------EKVAACNSFG-FGGSNSHAVLRSFT----RY--D-S----------N------H-L---------------PQK-----K-T------RCIVCFSGKSQKSLKNCL-------------------- 415 ------------------------VAIVGVGCRFP-G-A---NDVEEFWRVLS-AGEDHV-VEVP-G--D-RW-NVDA--FYD----PDGDARGKT-YVRLAGFV-----H-G--HD-EFDNRVFSISDL-EAASMDPQQRFAVECTFMALENAGITR--------GQIMG--SNTGVYL---------------------------------------G-VMNNDY--KSMY-GL-----------Q----S----PTNNYTLTGVSDSNVAARLSYVFDLRGNS------LVVNTACSSSLEAIHLASSALRAGEVEMAIAGGVNCMMDP-GIFIQLSRARMASPSGKSQAFSAHAD--------------------------------------------------------------------GYARGEGCGILILKRLG-D--------------A--RLAGDRVWA-TIY-TGAN--QDGHAVT-------P---MTAPSWKQQKVLFNDVIKR-A-KVPL-DRIEYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPVEIRSLG-EFFL-----------------------------------------------------------------EN-CS--P-----C-RRLVGSVKTN-IGHLESAAGVAGVIKVLLMMRHDKYVPSLH-FT-----K--PNPRID-FKLYNMTVPT--ALS-DWLT---------PEKLALVNSFS-FGGTNSHAVLASSP----Q---I-R------Q---L-PE--AL--DST--EAP-------------------------SVVCLSAVGKDSLA--K-------------------- 416 ------------------------IAVVGVGGRFP-G-A---QDVEEFWRLLL-NKENHV-KDI-PP--E-RW-HNDA--FYD----SNGEVPGKS-YVKKAGLL-----D-N--HD-VFDNRLFGINDM-EAERMDPQQHYVLECTHMALENAGFTR--------AMMAG--SKTGVYI---------------------------------------G-MMNRDY--CEEG-VH-----------D----V-YR-SSNNYTVTGVSPSITAARVSYVYDLRGPS------MTVDTACSSSLVALHLGAQAIVAGECDMAICGGVSSILLP-DLFIIMSRARLMSATGQSQAFSQTAD--------------------------------------------------------------------GYARGEGCGVVILKRLG-QAVR----------------DRDHIWG-VV-GTLCN--QDGRTAT-------P---ITAPSGVQQVNLLREVYSK-F-KVNP-RDVTYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEVNALG-QFFG-ST--D------------------------------------------------------------------R-----P-PLPIGSVKTN-IGHLEPAAGMAGLIKVLLMIRHQKYVPTVL-FS-----D--LNPQLD-FAGYGFHVCR--DVS-DWKV--S-P--G-QLRIASVNSFG-FGGTNSHAIVQEYM----PN--T------A-E------------K---------R-SL-AG-------E--------------P------------------------------- 417 ------------------------VAVVGLGCRLP-G-A---QDHQAYWGLLS-KGENHL-KPI-PE--E-RW-SEET--FYH----PDPDHPGTS-HTRHAGFL-----T-D--YD-KFDNRFFGINDL-EAARMDPQQRYALEGTHMALENAGLTR--------EAVAA--SRTGVYI---------------------------------------G-VMNGDY--VRLC-TG-----------D----L-K--ATNAYTVTGSSLSLIANRVSFAYDLRGPS------LVLDTACSSSLVAIHLGVQAIRAGECDMALCGGVNSILLP-DTHVLLTKTRMTSPTGQSQAFSDTAD--------------------------------------------------------------------GYARSEGCGMVLLKPLA-KALQ----------------DGDRVWA-VV-GSGCN--QDGRAAT-------P---ITAPSASQQVSLLQQVYQR-W-QVDP-DLVDYIEAHG-----------------------------------------------------------------------T-GTPL------G------DPVEVRALG-EFFG-KT--D------------------------------------------------------------------R-----P-RV-VGSLKTN-VGHLESAAGVAGLIKLLLMIQHRQIAPTLL-FS-----D--LNPKLH-LDRYGFEVPT--ALT-AWTV--P-E--G-KPRVACVNSFG-FGGSNSHVVVQEFL----PP--R------E-G---T-ET--AE-E-AP---PERH-VL-AF-------SGS-------TRESLQ------------------------------- 418 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVFV---------------------------------------G-SMNTDF--NMLM-LH-----------N----V--E-SVDQYSVTGHATSVIANRVSYQFNLTGPS------MSIDTACSSSLVAIHQAILAMRAGDCSHAICGGINLIAHP-QVFNMLCKARMLSPTGQCHTFSNNAD--------------------------------------------------------------------GYTRGEGCGIVILKPLT-K--------------A--LADGDNIWG-TVS-TGLN--QDGHFEQ-------P---ITAPSQKQQESLLEEVFTR-H-KIDP-GSVQYIEAHG-----------------------------------------------------------------------T-GTRR------G------DPVEVGAFG-SFFS-NH--GR-A--R------------------------------------------------------------K--------RFIGSVKTN-IGHLESAAGIAGLIKVFLMMKHGAIVPSLH-FD-EP------NKLID-FNSFQFVVPT--TLT-QWEG--D-------EKVACLNSFG-FGGANSHAVVK-------------------------------------------------------------------------------------------------------- 419 ----------------------------------------------------------------------------------------------------RRSTIP------D--VNV-FDAEFFGYPE-NEALHSNLLLRHLLELVYECVVDAGLTL--------DALNQH--AVGTYL---------------------------------------G-CTFSDA--DVI-TT---------------------SIT-TDSKETNLRSSLVSQLQNWFRFRGPV------MTVDTACSSSISALHAAVMDIRNGRCDFAVVTAINLIISP-NCSQTFNRLGMLSKTGDSHFGDISAN--------------------------------------------------------------------GYVRSDGAGVVLLARSP-E---------------LCER----IYAS-IADIDVN--CDGYKEE-------G---IVYPSRESQANLLRGLYG-E-GRIPV-SNVNYVEAHG-----------------------------------------------------------------------T-GTQI------G------DHVELNALN-DVLG-SG--R------------------------------------------------------------------S-----D-PLPVGSVKSC-MGHCEAAAGMSGLIKCLLSFHHGFIPPSLH-YK-----T--PNPKIEGIPKGTMRVAD--VPI-PLKG----H----M-SIVGLSSFG-FGGVNGHVVLMSYN----NP--I-D------S---E-KE--G----G------------------------------TFLIPLTLRSEEGVAKI--------------------- 420 ------------------------IAIVGLGCRFP-G-A---SNLREFWNVLV-NGENHV-GEVP-S--D-RW-NMDA--FFD----ANPDAIGKS-YARKAGFI-----D-N--YD-HFDNKLFKINES-EAAQMDPQQRQVLECTYMALENAGITR--------EDIAG--KDVGVYL---------------------------------------G-AMNSDY--GEMV-ST-----------T----S--N-ELNNNTVTGQAGSIVANRVSYVFDLRGPS------MIIDTACSSSIVAIHQAILGIKSGDCSMAISGAVNILMSP-FAFVKLSKARMMSPTGQCHAFSNKAD--------------------------------------------------------------------GYTRGEGCGIVILKTLK-Q--------------A--ELDGDCIWG-TIV-TGLN--QDGRRAT-------P---ITAPSDKQQESLIDEIYTK-F-NVDP-ADIDYIEAHG-----------------------------------------------------------------------T-GTKR------G------DPTEVDALG-SMFQ-KH--PR-Q------------------------------------------------------------------------RFLGSVKTN-IGHLESAAGIAGLVKVLLMMKHNTVVPSLH-FD-KP------NELID-FDKYQLVVPT--TTF-PWTN--E-------NKQACINSFG-FGGSNSHVVVKDYS----MK--N-----------------------------------------------------------------------S-------------------- 421 ------------------------VAIVGIAAITP-G-A---ENIRDFWRLLE-NGENHI-TDVP-A--S-RW-DADA--FYD----SDPLKPGKA-YVKKAGFV-----K-D--VE-KFDNVFFEINDY-EAASLDPQQSLVLECTHMALEDGGFTR--------TQMAG--TSTGVFI---------------------------------------G-AMTTDH--GSYY-PA-----------G----S--P-DVDSYTATGVSNSMLAGRVSFVYNLLGPS------MVIDTACSSSLVAIHQGIQAIKNGDCDMAICGGVNYIGAP-TIFVQLSKTKMLSPTGQSRAFSADAD--------------------------------------------------------------------GYVRGEGCGIVVLKSLK-D--------------A--LHNNDRIWA-TVV-SGVN--QDGHTVT-------P---VTAPSGTQQEKLMTDIYTK-Y-GVDV-SRLDYIEAHG-----------------------------------------------------------------------T-GTQA------G------DPVEVNAIG-KFLK-AM---G----Q------------------------------------------------------------P-----R-TRYIGSVKTN-IGHLEAGAGVIGVIKVLLMMKHNTIVPSLH-C---K--K--VNPLID-LENLGLIVPQ--SLV-EWES--K-------DKMACCNSFG-FGGTNSHVVLQTFH----KE--K-N----------L------V-I-E---------------T-----R-S------SNVVCFSGKTKQS----L-------------------- 422 ------------------------IAIIGIACKTP-G-A---ENIRDFWRILL-NGENHI-TEVP-P--S-RW-NGEV--FYD----EDPNKQGKT-NVRRAGFV-----K-G--IE-EFDNGFFGINDY-EAFSMDPQQRFVLECTHMALEDGGLTK--------AKISG--TNTGVFI---------------------------------------G-AMNSDH--SCLL-SA-----------G----S----QTDRYGVTGATNAILAARVSYVYNFQGPC------MVLDTACSSALVCIHAGAQAIRNGDCDMAICGGTNYMGTP-GLFVQLSKSAMISPEGLSKAFSAKAD--------------------------------------------------------------------GYARAEGCGIVVLKRLK-D--------------A--IRDNDKIWA-TVV-TGIN--QDGHTVT-------P---MTTPSGKQQVELMRRVYKK-H-NIDA-YKVDYIEAHG-----------------------------------------------------------------------A-GTQA------G------DPVEANALG-KFLK-EA---S----D------------------------------------------------------------H-----R-TRYIGSVKTN-VGHLESASGAIGVIKVLLMMKHDLIVPSLL-W---G--E--VNPQIN-LNELGLIIPR--QPI-KWKK--E-------EKMACCNSFG-FGGTNAHAVFQTHQ----LR--H-P----------K--D--KN-T-S---------------R-----H-E------SSIICFSGKSILSL---K-------------------- 423 ------------------------IVIAGCAARLP-R-S---HDIDEFTQNLY-DKIYMN-TT---TQKAGRY-EDG-------------L-Y--G-NQSIMCAMP--------DIDK-FDAAYFGMHPS-MAFATDPNCRMLSERCYEAIIDAGESL--------ETMKGS--RTGVFV---------------------------------------G-ALQSDS--TEWG-RT----------------Q--E-RMNGYTFIGYVACHLANRLSYFFDFRGP------S--------------------------------------------------------------------FTLDSACSSVLAALEVGMMQIRMGHLDYAIIGTSNLALDPLGSLTATKVGMLCND-GKCKAFDAKANGFVRADGNMCILLSKKA-L--------------A--KR----SYC-TVVHVRGN--SDGFTPA-------G---IAVPSAESQSQLLKDMYID-L-GIDP-NLVTYAEAHG-----------------------------------------------------------------------P-GTAV------------GDGIEVDAIA-GVLCTN------R---------------------------------------------------------------K-----S-PLLIGSVKTN-MGHCEGSAGMASIIKCIIGIHQEHLPPNLH-F---E--T--PNPNINSLFDGRVKVVT--EAT-PFQS-----------GLISISSFG-VGGTNYNAVLRSD--K--KV--P-R------A---P-HP--DK-D-------------------------S------PRLFVYGARTSQGAQQVL-------------------- 424 ------------------------VCVSGISGRMP-E-S--A-NMQEFRDHLM-KKEDMV-TA---DNR--RW-EV-------------GL-H--G-VPPRNGKLL--------EIAK-FDAGFFGVHPK-QADCMDPQLRMLLEVSYEAIIDSGQTL--------QSVRGS--RTGVFI---------------------------------------G-VSIAEA--SEAW-SA---D------------P--E-TLVGYSMPGCCKAMFANRISFFFDFTGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALMNIRMGFIDSALVGGTNLCLKTQTSLQFTRMGMVSPD-GACKTFDASGDGYCRSEAVMAIFLQKSA-D--------------C--RR----IYA-TVVHTRAN--ADGYKEQ-------G---ITFPSGNLQKRLINEVYND-I-GLNP-KDIAYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINSIV-DVFC-K--D---R----------------------------------------------------------------D----T-PLLIGSTKSN-MGHPEAASGLTSLAKIIIAMEERVIPPNLH-Y---K--T--PNPEIPGLSDGSLQVIT--ECT-KWDG-----------GLVAMNSFG-FGGANVHAVYRSY--D--AE--P-R------E----PHM--AS-E-------------------------K------PRLFTFSARSEEGVREVL-------------------- 425 ------------------------ICIAGISGRFP-E-S---DCVGEFEHNLL-NKINML-TT---DSR--RW-EPW-------------H-M--G-IPPVNGKLK--------NIDK-FDAEFFGVNMK-QAHYIDPQQRLLMEVVYEALIDAGEDI--------ESLRGS--RTGVYV---------------------------------------G-CTCAEA--EAAW-MQ---C------------------QSPYAMQGVAHACMPNRVSHFFDWKGP--------------------------------------------------------------------------SCNYDTACSSSIVCLEAAETHIRTGVIDAAIVASCNLVMRPSTSWAFQHMSMLSSS--GCKAFDAAGDGFIRSECVSAVWLRKKD-D--------------A--KR----IYS-TVLGTMTN--QDGYTSN-------G---LLYPNTLAQEELMRDLYTH-F-KINP-HEVKYFECHG-----------------------------------------------------------------------T-GTPA------------GDPNELRAIR-SVIC-E--N---R----------------------------------------------------------------K----D-PLMIGSTKTN-MGHGEIASGMCSLAKMTIAMQTRLIPPNLH-F---N--N--PNPKIPGLLDGTFKVVT--EPT-PWKG----------G-LMAVNSFG-MSGSNGHSVLKSY--D--TR--L-A------T----PHP--AS-K-------------------------K------PRLFVYSARTEEGMKAIL-------------------- 426 ------------------------IVISGISGRFS-E-A---SNMEEFYDNLI-NHVDMI-SD---NEK--RF-PRG---------------Y--K-DIHISGKMK--------EVDK-FDNEFFNQTAK-YVDVMSPEMRFGMEVAYEAIIDAGLSL--------DEVRET--RTGVYI---------------------------------------V-GPTVDS--MRAY-NN---D------------I--D-NINTNVVIGTINSVIANKISFALGLNGP------S--------------------------------------------------------------------LAIDTACSSSLYALEEALRAVREGVVDQALVGGVMFFANPFMAYDFASMPLLSQTDHRCKSFDADCSGYVRGEGGAYILIQKRK-D--------------S--KR----SYA-RIIHARCN--VDGRSET-------G---FLAPWGWRQYQLLRDVYME-S-GLKT-SQISYVECHG-----------------------------------------------------------------------T-GTKA------------GDPEEVVGLTTDGLM-IN-G---R----------------------------------------------------------------E--EGK-PLLIGSVKSN-CGHGEWTSGLVALAKVVLTIKNKIIPANLH-F---D--T--PNPNIPNLINGKVKVVA--ENT-EYDG-----------GYIGINSFG-VGGANAHVIIGDS--D--TR--Q-S------A----PSP--AG-K-------------------------E------PRLFTYATRTEEGAQVLL-------------------- 427 ------------------------VGISGISGRLP-E-S--N-NIQEFRDHLM-NKEDMV-TA---DNR--RW-EV-------------GL-H--G-CPARNGKVK--------ELTK-FDAGFFGVHPK-QADCMDPQLRMLLEASYEAIIDAGQSM--------ESVRGS--RTGVYV---------------------------------------G-VSMSDA--SDAW-TM---E------------T--E-GMVGYTMPGCCRAMFANRVSFFFDFKGP------S--------------------------------------------------------------------YSVDTACSSSMMCLDQALMGIRTGLIDSAVVCGTNLCLKPNTSLQFVRMGMTSPD-GACKTFDASANGYCRSEAIMAIFLQKEA-D--------------C--KR----IYA-TVVHTKSN--CDGYKEQ-------G---ITFPSGELQKSLINDVYSE-I-GINP-VDVNYIEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINTIV-DVFC-K--D---R----------------------------------------------------------------N----E-PLLIGSTKSN-MGHPEAASGLTSIAKILISMEEKIIPPNLH-F---N--K--PNPDIPGLTDGSLKVVS--ECT-RWNG-----------GLVAMNSFG-FGGANVHAIFKSH--D--KE--L-K------E----PHP--AS-Q-------------------------K------PRLFTYCGRTEAGVRAVL-------------------- 428 ------------------------IVISGISGRYP-E-S---NNVAEFQENLM-NKVHMV-TT---DDR--RW-VSDN------------Y-P--D-IPDTLGKLK--------NIDL-FDADFFNIPSR-AVEVMDPHQRMLLEVVYEAIIDAGESM--------TSVKGS--RTGVYV---------------------------------------G-VYSSES--EHAW-WV---D------------------ANPNLAGGLAHAMLPNRVSFFFDLKGP--------------------------------------------------------------------------SSVYDTACSTAFTCLEAAERHMRAGLIDSAVVAATNLVLRPVTSRSMNALGMLSQT-GCCHAFDAKGDGFVRAETVSAMILKKAE-D--------------A--KR----IYA-SVVGTLTN--QDGYGPD-------G---IFFPNSNSQEQLIRDVYMN-F-KVDP-NDIQFFECHG-----------------------------------------------------------------------P-GTQA------------GDPQETRAIC-SAVC-A--K---R----------------------------------------------------------------K----E-PLLLSSTKTN-MGHAECASGIASITKIIIAMNTRVIPANLH-F---E--T--PNPNIPGLFDGRLKVIT--EHT-PWD-----------GGLVAANSFG-MGGSNGHTVFRSY--D--KK--K-S------Q----VHP--AS-K-------------------------M------PRLFLYSGRTEEGLQGVF-------------------- 429 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKGT--RTGVYV---------------------------------------G-MGSSEA--EHAW-MK---K------------------MSTYIVMGCPHTMCPNRISFFFDLNGP------SIAYDTACSSSLVAMEAAVTHMRDGVVDNAIVAGANICFRA-LTSKIFQNIGFLGHE-G--------------------------------------------------------------------CKAFDVSGDGFVRGEVISAILLKKAE-E--------------S--KR----IYC-SVTACMTN--NDGFTPQ-------G---ITFPNGQAQEQLMRDVYAN-Y-NLSP-KEVKYFECHG-----------------------------------------------------------------------T-GTPA------------GDPQETGAIS-RVMCPP--D---R----------------------------------------------------------------E----G-PLLIGSVKSN-MGHAEFGSGMASMTKMVIMMHEGVIAPNLH-F---N--T--PNPKIEGLMDGRMEVVT--EPT-LWS-----------GGYAAVNSFG-MGGSNAHLVLRS------------------------------------------------------------------------------------------------------- 430 ---------------------------------------------------------------------------------------------------------K--------DLSR-FDADFFGYNTK-SADVVDPQQRMMLEVVYEALIDAGEDI--------GKLRGT--RAGVYL---------------------------------------G-LTVCDA--EHAW-YG---G------------P------NDNVLHGCGVAALPGRVSHFFDFVGP--------------------------------------------------------------------------SSTYDTACSSSLVALEAAETHLRNGYVDMAIVGAVNFILKPAMTGLFVGMSMLSKD--FCKPFDANGGGFARADGIAAVVLRRSS-D--------------A--KR----IYA-SLCGSMTN--QDGFSTD-------G---MLFPHMSAQEQLMRDVYKH-F-KVNV-NEVEYFECHG-----------------------------------------------------------------------T-GTAA------------GDPVETTAIT-RVYW-P--E---R----------------------------------------------------------------K----E-PLKVGSTKSN-MGHCEVASGMASLSKMIISIHEKTIPPNLH-F---N--T--PNPKIPALLDGRFKVVD--EPT-PIN-----------GGLMAINSFG-MSGTNGHAVIRPN--L--KR--H-S------G----THP--AS-N-------------------------K------PRLFAYGARTEEGLDKIL-------------------- 431 ---------------------------------------------------MY-NKTYMV-S----DEG--RW-ENG-------------Y-W--D-LPSKMGKVK--------DIAS-FDTEFFGISPK-ACDLTDPQQRVLLEVAYEAIIDAGLSL--------ESIKGS--RTGVYI---------------------------------------G-IGVSDA--EDAW-VT---P------------T----PISSYAMQGTAHAIAPNRISFTFDLHGP--------------------------------------------------------------------------SCSYDTACSTSLVALEAAECHMRSGVIDRAIVGAVNFLSRPSTTWHFKKLNMMSNI--GCQAFDAAGDGFVRSEGCGAFVLERAA-E--------------A--KR----SYA-TVMGTLSN--CDGWSID-------G---LLFPNTLAQEQLIRDVYHN-F-NIDP-NDLAFFDCHG-----------------------------------------------------------------------T-GTPA------------GDPVEANAIT-RVIC-E--K---R----------------------------------------------------------------K----E-PLTLVSTKDT-VGHCEIASGLASISRTIITLQNAMIPANIH-F---K--N--PNQKIPALLDGRLVINK--EAM-PIKD----------GSLVSINSFG-MTGTNGHTVLRGT--N--NR--R-T------A----PHP--AS-D-------------------------K------PRLFIYGARTEEGINNIL-------------------- 432 ------------------------IVVAGISGKYP-M-S---DDLDEFEDNLI-NGVNMV-G----NEA--RW-EPG-------------H-M--G-LKSVMGKIR--------HIEH-FDAQFFSITPK-ACEVTDPQQRVLLEVVYEAIIDSGYTP--------QDLRGL--RTGVYV---------------------------------------G-CGMSDA--EDAW-LV---P------------E------KPYAVMGTLHSIMPNRVSYVFGFNGP--------------------------------------------------------------------------SIEYDTACSSCIVAQEAAEQHMRMGVIDAAIIGTVNFLMRPNTFFHFKNMNMLGSE--ASKAFDASSDGFVRSEGCGAFLMMRKD-L--------------A--KR----NYA-TIVGTLTN--NDGYKRE-------G---IMYPGTFAQEQLIRDVYHN-F-NIDV-DDIKWFETHG-----------------------------------------------------------------------T-GTPA------------GDPVEANAID-RAVC-S--R---K----------------------------------------------------------------K----D-PLLVTSTKSN-CGHCELSSGLTSVTRVCLNMERGEINANLH-F---K--T--PNPKIPALLEGRMKICT--EPT-PYNE----------GDLCSINSFG-MTGTNGHTVLKST--N--KR--R-T------E----PHP--AS-N-------------------------V------PRLFVYSARTEEGVKGIL-------------------- 433 ------------------------IVYSGFSGRYP-E-S---DNVDELKENLF-NKLNMV-VV---DNR--RW-ELG-------------Y-W--G-LPDTYGKIK--------NISL-FDADFFGYGAK-AAEVIDPQQRIMLEVVYEALCDAGEDI--------SAVRGT--RTGVYM---------------------------------------G-VMITDA--EHAW-FG---G------------P------NDYCLSGCVQAALANRVSHFFDFHGP--------------------------------------------------------------------------SCTYDTACSSSIYALEAAETHLRSGAIDMAIVGAANFVLKPGLTATYFHMNMLSTD--YCRAFDSAGDGFTRADGCIAIVLRRAT-D--------------A--KR----IYA-TDLGTMTN--NDGFHTN-------G---LLYPNMSAQEQLMRDVYNH-F-KIDV-NDIEFFECHG-----------------------------------------------------------------------T-GTPA------------GDPVETTAID-RVYW-P--K---R----------------------------------------------------------------K----A-PLKVGSIKSN-VGHTEVASGLAGMSKLFITINEKRIPPNLH-F---N--N--PNPNVPGLFNGRLKVID--EAT-EFN-----------GGLMVLNSFG-MSGSNAHTVLRPY--M--EK--K-T------G----VHP--AS-T-------------------------K------PRLFVYGCRTEQGVNEIL-------------------- 434 ------------------------LCIAGISGRFP-E-S---ENMAEFEYNLM-NHVNMV-TI---DNR--RW-EPG-------------Y-M--G-LTTNIGKLK--------TLSK-FDAEFFNTSQK-HAEYIDPQQRILLEVVYEALVDAGEDI--------QALRGS--RTGVYV---------------------------------------A-ILCAEA--EAAW-MK---Y------------------IDCNVLQGTTHACAANRVSFFFDFKGP--------------------------------------------------------------------------SIGYDSACSTSLVVLEAAEKDIREGIIDQAVVAAVNIVTRPATSWGFQYSGMTSEI--GCQAFDIKGDGFVRSEGISAVLLRKRE-D--------------C--KR----IYA-SVLGTMNN--CDGFAAT-------G---FLFPNTLAQEQLLMDVYEK-F-KINP-SDVCYFECHG-----------------------------------------------------------------------T-GTPA------------GDPVECRAVQ-AVMC-K--D---R----------------------------------------------------------------K----E-PLLIGSTKTN-MGHGEPAAGMCSIAKVILSIQNEMIPANLH-F---E--T--PNPNVTGLFDGSLKVVD--QNT-PLKE----------GGLMAVQNFG-LGGSNAHTCLKPY--R--VK--A-K------A----PHP--AS-T-------------------------K------PRLFVYSARTEEGMGHIL-------------------- 435 --------------------------------------------MAEFEYNLM-NHVDMV-TV---DNR--RW-EPD-------------H-R--G-VSSRIGKVK--------SLSK-FDADFFSTSQK-HANYVDPQQRIMLEVVYEALIDAGEDI--------QALRGS--RTGVYI---------------------------------------G-VLGSEA--EAGW-MR---Y------------------LDASVVQGTSHACGPNRISYFFDFKGP--------------------------------------------------------------------------SVAYDSACSSSIVVMEAAEKDLRDGTIDQAIVGASNVIVRPATSWGFKINKMTSEK--GCQAFDKSGDGFVRSEGVSAVVLKKKQ-D--------------C--KR----IYA-TVLGSMSN--CDGFTAN-------G---FIFPNTLAQEQLMTDLYGR-Y-NINP-SEVTFIECHG-----------------------------------------------------------------------T-GTPA------------GDPAECRAIA-AVMC-K--D---R----------------------------------------------------------------K----E-PLLIGSTKTN-MGHAEPAAGMCSLAKVILAIQNQLIPANLY-F---K--N--PNPNIPSLFDGRLKVVD--ENT-PLKD----------G-LIAINSFG-MGGANAHTCIRPY--K--SQ--A-K------Q----SHP--AS-V-------------------------K------PRLFVYSARTEEGMAHIL-------------------- 436 ------------------------IAISGISGRSP-E-S--Y-NLQELRDNLM-NKVDMV-TE---DNR--RW-EV-------------GL-H--G-LPPRMGKVP--------ELTK-FDAGFFGVHPK-QADCMDPQLRTLLEASYEAIIDAGQSM--------ESVRGS--RTGVYV---------------------------------------G-VSMSDS--SDAW-TM---H------------T--E-KMVGYTMPGCCRAMFANRISFFFDFKGP------S--------------------------------------------------------------------FALDTACSSTMMCLDQALLAIRSGIIDSALVGGANLCLKPNTSLQFTRMGMTSPD-GACKTFDASANGYVRSEAIMAMFVQKAA-D--------------C--KR----IYA-TVVHAKSN--CDGYKEQ-------G---VTFPSGELQKRLIYDVYNE-I-GINP-KDISYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINSIV-DVFC-K--D---R----------------------------------------------------------------T----D-PLLIGSTKSC-MGHPEAVSGLTSIAKIIIAMEERVLPPNLH-Y---K--N--PNPEIPGLTDGSLKVLT--ECT-PWEG-----------GLVAMNSFG-FGGANVHAIYKPN--E--KE--Q-D------K----PHP--AS-D-------------------------Q------VRLFTYAARTEEGIRTVL-------------------- 437 ------------------------IAISGISGRLP-E-S--D-NIAEFRDHLM-KGEDMV-TE---DDR--RW-EV-------------GL-H--G-TPARNGKLK--------DLKG-FDASFFGVHPK-QSNRMDPQLRMLLEASYEAIIDAGQSM--------ESVRGS--RTGVYV---------------------------------------G-VSLSDA--SDGW-TI---D------------S--E-KLIGYTMPGCCRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------FAVDTACSSSMMCLDQAVMAIRSGLIESALIGGTNLCLKPNSSLQFTRMEMTSPD-GACKTWDASANGYCRSEAIMAMFLQKSK-D--------------C--RR----LYA-TVVHVKSN--SDGYKEQ-------G---VTFPSGIAQKQLIEEIYHE-I-GISP-LEIGYFEAHG-----------------------------------------------------------------------T-GTKV------------GDPQESNTVV-DVFC-K--G---R----------------------------------------------------------------K----E-SLLIGSTKSN-MGHPEAASGLSSIAKIIISMEEQVIPPNLH-F---K--N--PNPDIPGLTDGSLKVVT--ENT-RWNG-----------GLVAMNSFG-FGGANVHALYRSN--T--KE--L-K------E----PHT--AS-D-------------------------K------TRLFTYAGRTEEGVRAVL-------------------- 438 ------------------------IAIAGMSGRFP-E-S---DGMTEFQQNLF-NKVNMI-TA---DNR--RW-EPG-------------Y-M--G-TPLVMGKVK--------HLNK-FDAEFFGINNL-AADTMDPQMRAVLETAYEALVDAGESM--------ASLKGS--RTGVYV---------------------------------------G-VTQSEA--ESAW-FG---------------------KKNQYVILGCPHSVIPNRISFFFDLKGP--------------------------------------------------------------------------SVAYDTACSSSLTCLEAAERHMRDGVVDQAIICAVNFNMRPATSKVFTMMSMLGDT--ACKVFDQSGDGFVRGEVAGSFVLKKSA-A--------------A--KR----IYA-TVEGCLVN--CDGFTPK-------G---ITFPNRLGQEEVMRDVYLN-Y-KINP-HDVKYFEAHG-----------------------------------------------------------------------T-GTPA------------GDPEETSSIC-NAMC-SQ-G---R----------------------------------------------------------------R----D-PLLIGSAKSN-CGHGEVASGMAAFAKVVIACNERVIPPNLH-F---N--T--PNPNIPGLFDGRLKVVT--EPT-PLDP----------GSLVAVNSFG-MTGANSHAVLRPF--E--KK--R--------A----VHQ--AS-Q-------------------------K------PRLFVYGARTEVGIQTIL-------------------- 439 --------------------------------------------------NLF-NKVDMA-SC---DNR--RW-EPG-------------Y-M--G-TPPYSCKLK--------TVNK-FDADFFSVPHR-IAELTDPQARLLLETAYEAIIDAGESL--------ESLAGS--KTGVYI---------------------------------------G-ISGSEA--EGAW-VG---K------------------KAHYVTIGVPHNMVPNRISFFFDLKGP--------------------------------------------------------------------------SIAYDTACSSSLTAFEAAIRHMSDGIIDAAIIGAVNLTLKPALSQAYKQMSMLGSG--PCRAFDAAADGFIRAEACACSYITKAS-T--------------A--KR----NYA-TVVGALTN--CDGYAST-------G---LTFPNSLAQEQLMKDVYAT-Y-NINP-LDIKYFETHG-----------------------------------------------------------------------T-GTPA------------GDPVETGSIL-EATCEN------R----------------------------------------------------------------K----E-PLLIGSTKSN-MGHAEVGAGMASLTKVVIACNARSIPPNLH-Y---N--S--PNPNIKGLVEGRLKVVT--EPT-PLPA----------GGLVCLNSFG-FTGANAHMTIRPY--E--KK--N--------A----AHP--AS-E-------------------------K------ARLFVYGARSEDGINGIL-------------------- 440 ------------------------IVISGVSGRYP-E-S---ANVGEFQHNLF-NKINMI-TV---DNR--RW-EKG-------------Y-M--G-TPEVMGKLK--------SLEK-FDNDFFGVHPK-AADTMCPAQRILTEVAYEAVIDAGESL--------ATMKGT--RTGVYV---------------------------------------G-VTTSDA--SEAW-MG---L------------------RDAYVLTGVTCCVFPNRISYAMDLKGP--------------------------------------------------------------------------SLTYDTACSTSLACMEAAYRHIRDGVVDSAIVGVVNLCLKPGTSNAFLGMGMMGDF--ACRSFDAKGNGFVRAETVSAVLIKKAP-D--------------A--KR----IYS-TILGCLIN--CDGYAPT-------G---ITFPNTIAQEELMRDVYMN-F-NIDP-DEVKYFECHG-----------------------------------------------------------------------T-GTPA------------GDPAETNAVC-RVLF-N--K---R----------------------------------------------------------------K----G-PLLIGSTKSN-MGHSEVAAGMAALTKVLISINESCIPPNLH-Y---E--T--PNPKIPGLVDGRLKVVT--EPT-PWE-----------GGLMALSSFG-MTGANGHAVLRPH--D--KK--A-S------T----PHP--AS-N-------------------------K------ARLFVFGARTEEGLQRIF-------------------- 441 ------------------------IVLAGLSGRYP-E-C---ENVEELQNNLF-NKVDML-ST---DDR--RW-PSG-------------F-R--G-IPDLSGKLK--------NVTK-FDTNFFGMPNK-VADTTDPQLRILLETAYEAVIDAGESM--------ASLEGS--NTGVYI---------------------------------------G-ATNPDA--EMAW-VG---K------------------RGHYTAIGTTISGFPNRISYFFDLRGP--------------------------------------------------------------------------SISYATACASSVTALEAADRHFRMGLIDSAIVGAVNLTFKHLTSKNYVEMSMLGTG--PCRSFDASGDGFVRAEAIVCCFLTKES-L--------------A--KR----NYA-NVLGAMAN--CDGYAST-------G---LIFPNSEAQERLMKNFYKT-F-NLNP-FDVKYFECHG-----------------------------------------------------------------------T-GTVA------------GDPVETRAIV-NALHSK--E---R----------------------------------------------------------------Q----D-PVLIGSVKSN-LGHCEPAAGMAAISKVIIACNTGLIPPNIH-F---H--N--PNPKIPGLLDGRLKVVT--EAT-PLTS----------GGLIAINSFG-FTGSNAHCCVRPN--E--KK--N--------A----AHP--NS---------------------------------------------------N-------------------- 442 ------------------------VIISGISGRLP-E-S--D-NIAEFRDHLM-NMEDMV-TE---DNR--RW-EV-------------GL-Y--G-TPRRNGKLK--------DLTK-FDASFFGVHPK-QTNCMDPQLRMLMEVAYEAITDAGYSM--------ESMRGS--KTGVYV---------------------------------------G-VSLSDA--ADAW-TL---E------------T--E-GMEGYTMPGCCRAMFANRLSFFFDFKGP------S--------------------------------------------------------------------FAVDTACSSSMMCLNRALMAIRNGTIDSALVCGTNLCLKPNSSLQFTRMGMTSPD-GACKTWDASANGYCRSEAVMAILLQKRK-D--------------C--RR----VYA-TLVHSKTN--SDGYKEQ-------G---VTFPSGAAQKELIQEVYHE-I-GINP-LDINYFEAHG-----------------------------------------------------------------------T-GTKV------------GDPQETNSIV-DVFC-K--G---R----------------------------------------------------------------K----G-PLLVGSTKSN-MGHPEAASGLTSIAKIIIAMEERVIPPNLH-F---K--T--PNPEIPGLTDGSVQVVT--ENT-RWEG-----------GYVAMNSFG-FGGANVHALYRSN--E--KE--Q-T------E----AHV--AS-Q-------------------------K------PRLFTYAARTEEGVKAVL-------------------- 443 ------------------------IVIAGLSGRYP-E-S---ANVKEFRDNLF-SGTSMV-TI---DNR--RW-EPG-------------Y-K--N-TPLVMSKLK--------DISR-FDHEFFRINNK-EADVMDPSIRILLEVAYEAVIDAGESI--------DSMKGT--RTGVYI---------------------------------------A-NNISEA--EAAW-MG-------------------K-DLEAYVVPGVTHCMLANRISYFFDLRAP--------------------------------------------------------------------------SCVYDTACSSSVVCMEAADTHLRTGVIDRAIVAACNILYRPATTEKFVGMKFLSQT--SCKTFDVNADGFVRAEVVSAVLLKKAG-E--------------A--KR----SYG-TLLGTMTN--NDGFNPN-------G---LLFPNIESQEELMRDLYMN-F-NIDP-NEIKYFECHG-----------------------------------------------------------------------T-GTQA------------GDPQETNSVC-NFMC-A--N---R----------------------------------------------------------------K----E-PLYIGSTKSN-MGHGEASSGFAALSKIIIGMHEGKIPANLH-F---E--T--PNPAIPGLFNGKLKVVT--EHL-PWN-----------GGCIAHNSFG-MGGTNAHMVIRSY--D--KK--A-T------K----PHP--AS-Q-------------------------L------PRLFVYSARTEEGLRGIF-------------------- 444 ------------------------VVISGVSGRFP-E-C---ANMSEFAENLY-NKVDML-TV---DNR--RW-EPG-------------Y-M--G-LPARFGKLK--------SVDK-FDADFFAINSK-VAEVTDPNQRLMLEVSYEAVIDAGHSM--------ASLKGS--RTGVYI---------------------------------------A-IYSAEA--EAAW-YG---K------------------EAAYVIQGTAHACMPNKISYFLDLKGP--------------------------------------------------------------------------SCAYDTACSSSIICLEAAMTHFRAGYIDSAIVGAVGLIFRPSSTSTFHGLNMLSEK--ACQAFDIAGDGFVRSEACSAIFLQKSP-G--------------A--RR----VYG-SVLGCMAN--CDGWVPN-------G---LLFPSTQVQEQLMRDLYSH-I-KINP-NEVRYFECHG-----------------------------------------------------------------------T-GTPA------------GDPAETRAIA-SVMC-E--D---R----------------------------------------------------------------K----G-PLLVGSTKTN-MGHGEVVSGMCSMAKMIISIQNGSIPPNLH-F---N--T--PNPKIPALLDGRFKVIT--EAE-PWEG----------G-MMAINSFG-MSGTNAHAVVRSY--D--NK--N--------A----PHP--AD-K-------------------------L------PRLFVYGGRTQEGINRIL-------------------- 445 ------------------------VAISGISGRLP-E-S--D-NVQEFRDNLM-SKVDMV-TE---DAR--RW-PV-------------GM-H--G-LPPRMGKVK--------ELTK-FDAGFFGVHPK-QADSMDPQLRMLLEASYEAIIDSGQSM--------ESVRGS--RTGVYI---------------------------------------G-VSLSDS--SDAW-TM---E------------T--E-GMVGYVMPGCCRAMFANRVSFFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALMGIRTGLIDSALVGGSNLCLKPNTSLQFTRMGMTSPD-GACKTFDASANGYCRSESIMAIFLQKVP-E--------------C--KR----IYA-TVVHTKAN--CDGYKEQ-------G---ITFPSGELQKRLIYDVYDE-I-GINP-KDINYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINSIV-DVFC-K--D---R----------------------------------------------------------------Q----G-PLLIGSTKSC-MGHPEAASGLTSIAKIIIAMEEGVVPPNLH-Y---N--T--PNPEIPGLTDGSLQVVS--ECT-PWPR-----------GLVAMNSFG-FGGANVHAIYKSH--D--KV--Q-Q------T----PHP--AS-D-------------------------K------VRLFTYCARTEPGMKAIL-------------------- 446 ------------------------VCISGVSGRLP-E-C---ANMEEFRDHLM-NKEDMV-TE---DNR--RW-EVGL--------------H--G-NPPKNGKLK--------DIRH-FDARFFGVHPM-QADNMDYQLKLLVEAAYEAIVDAGQTL--------DSVRGS--NTGVFM---------------------------------------G-AMRSDC--ADAW-TS---D------------K--S-VDIKYTMTGCTFSMLSNRVSFTFDLKGP------S--------------------------------------------------------------------YTINSACAGGMTALDHAVANIRLGVIDAALGGGVNLCLKPNFTLQFVRMKLAAPD-GLSKCFDASADGLCRSEGGVVMYNQKAP-D--------------C--KR----IYA-TVVNARSN--MDGARPR-------G---LTVPNDTGLRELMTETYQE-V-GVDP-SEVSYFEAHS-----------------------------------------------------------------------N-GLRV------------NDALEANSIT-DVYC-K--D---R----------------------------------------------------------------K----G-PLLIGSVKSN-MGHSEAASGLASVAKMIIAMEEGVIPPNLH-Y---N--T--PNPEIPGLVDGRLKVVT--DNT-PWAG-----------GLMATNCCG-LWGANVHAILRSH--D--KE--Q-G------E----PHP--AS-Q-------------------------K------PRLFTCCARTEEGVRAVL-------------------- 447 ------------------------VVISGISCRLP-E-S--D-SMEEFRQHLM-QGEDMV-TE---DNR--RW-EPGY--------------L--G-LPRRNGKLK--------DLSK-FDAAFFGVHPK-QADCMDPQLRMLLEVTYEALVDAGVDP--------QQ-RGR--RTGVFI---------------------------------------G-VSGSEA--SEAW-TA---D------------P--E-KTQGYMMTGCCRAMFANRLSYYFDFKGP------S--------------------------------------------------------------------YALDTACSSSLLALDHAVQNIRSGRCDSAIVGGSNLCLKPTTSLQFLKLGMLSPD-GACKAFDASGNGYVRSEGIVAIYLQKSR-D--------------A--KR----IYS-TVVHSKSN--CDGAKDQ-------G---ITFPSGEVQGQLLRELYSE-A-GLEP-SQVSYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIA-EVFC-S--K---R----------------------------------------------------------------S----S-PLLVGSTKSN-MGHPEPASGLSSIAKVLIAMEDGQIPPNLH-F---S--E--PNPDIPALADGRIQVVK--EKT-PWQG-----------GFAAVNSFG-FGGANVHTVLRSH----SKS--S--------S----PNA--GS-R-------------------------A------KRLFLYSSRTESGLRQVL-------------------- 448 ------------------------IAVVGIGCRFP-GRV---NSAADFWEVVR-EGRDCL-EPIP-D--E-RW-NVEA--YYS----PDPHSLGTH-VNRKGGFVQ------N--ID-NFDNGFFKIAPK-EAVNMDPQQRHLLEVTHEAFEDAGLVP--------SKLGG---KCGVYV---------------------------------------G-LGMMDY--PLMN-AS---E------------S--R-NFNAYTHTGMSHSVAANRISFAFNLQGPS------LATDTACASSMTALHLACTGLWNEECETSVVAGSNILLMP-EITCGFSALSVLSPESQSRPFDADAK--------------------------------------------------------------------GYVRSEGFGAILLKPLD-D--------------A--LRDGDNVYC-TLLGTGIA--ANGLTP--------S---ITMPCREAQAQLMTSVYEH-F-QVKR-DNLLYVEAHG-----------------------------------------------------------------------T-GTPV------------GDPIEAEAIG-QALA-KD--R------------------------------------------------------------------D-----E-PLKIGSGKSN-FGHLECAAGMISLVKVALMLKHRKLVPSIN-FQ-Q------PATPL--FSEWNIQVQT--KVE-DFPE--G------Q-HMIGVNNYG-FGGALAHAIMAEAP----AA--P-P------R---K-AG--TA-G-WS---FGPE-ET----K-----G-------RPLVVPLSARSQEALTALV-------------------- 449 ------------------------VVVSGVSGRLP-E-S--D-NMKEFRDNLM-NNIDMV-TE---DNR--RW-EPGM--------------H--G-LPRRNGKLK--------DISK-FDASFFGVHPK-QANAMDPQLRLLLEVTYEALVDAGVDP--------ASARGS--KTGVFI---------------------------------------G-CSASEA--HDAW-SS---Q------------P--E-KLTGYEMTGCTRSMFANRLSYYFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLLALDQALNAIRNGLCEAAIVGGCNMCFKPTTSLQFQKLNMLSPD-GTCKSFDVTGNGYCRSEAVVAIYIQRET-G--------------A--KR----IYA-TLVHSKNN--SDGNKKE-------G---ITFPSGEVQKKLLKEVYSE-A-KVDP-ALVTYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNSIV-DVFC-K--G---R----------------------------------------------------------------N----G-PLLIGSTKSN-MGHPEPASGLAALAKILVAIQEGFIPANLH-F---K--D--PNPDIPALLDGRLQVVS--ENT-AWNG-----------GYIGLNSFG-FGGSNVHVLLKSF----NKN--L-T------E----PHP--AA-K-------------------------S------VRLATYAGRTEEAVEFVL-------------------- 450 ------------------------IAIVGIGCRTS-G-A---DNIREFWRLLL-NGECHV-GDVP-E--N-RW-NKDA--FFS----EDPSAYGKA-YVQKGGFM-----K-D--IE-GFDNGLYGINDY-EASQMDPQQCLLLDCTSMALEDAGITR--------KQLAG--SSTGVYI---------------------------------------G-SMNPDH--RSTS-LG-----------M----T--S-KVGSYTASSSASSFLSCRLSYVFDLRGPS------MTVDTACSAALIAIHLGRQAILTGDCDQAICGGVNCMLLP-DVFVHLSKARMISPTGQCHTFSDKAD--------------------------------------------------------------------GYTRGDGCGIVILKRLT-D--------------A--LRDGDHIWA-TVS-TGTN--QDGRSVT-------P---VTAPSGQQQMKLLHSVYRK-F-SVDL-SRLDYIEAHG-----------------------------------------------------------------------T-GTPT------G------DPVEVNALG-TFLK-EK---G----Q------------------------------------------------------------A-----R-QRYIGSVKTN-IGHTESAAGALSVIKLCLMMKHNTIVPSLH-C---D--V--VNPNIH-LTDLNFVIPK--TPV-TWST--Q-------DKLCCCNSFG-FGGTNCHAILETV------------------------------------------------------------------------------------------------------ 451 ------------------------IAIVGIGCRTP-G-A---DNTQEFWRVLQ-NGECHI-TDVP-A--D-RW-NAKA--FLD----PDPMAPGKA-YVQKGGFL-----K-D--VE-GFDNRLYGINDF-EASSMDPQQCQLLECTTMAMQDAGITS--------AHLSG--SNTGVFI---------------------------------------G-SMNNDY--GTAF-MG-----------K----T--T-KMDNYTATGISNAVLAGRLSYVFNLTGPS------MVLDTACSASLVAIHQGCLAIRSGDCDAAICGGVSCMLSP-DMFIQLSKARMISPTGLCHAFSDQAD--------------------------------------------------------------------GYTRGEGCGVVILKRLT-H--------------A--IHDGDNIRA-ILY-TGTN--QDGHSVS-------P---MTAPSGEQQKKLLHSVYDK-F-QVDI-SHVDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEANSLG-SFFK-EK---G----P------------------------------------------------------------P-----R-ERYIGSVKTN-IGHTESAAGVLGLIKVLLMMEHNLIVPSLH-C---D--V--ANPKID-LSGHKLVVPK--TLV-PWTK--P-------HKMAACNSFG-FGGSNSHAVVRSYK----RQ--D-L----------D------Q-T---------------PRN-----K-S------RCIVCFSGKSEHSL---K-------------------- 452 ------------------------IAIIGVGCITP-G-A---DNLDEFWRVLV-NGENHV-IDIP-A--D-RW-NVNA--YYS----TDSMAIGKS-YVTRAGLV-----R-A--PD-EWDNRLFGINDF-EANQTDPQQRMVLDCTHMALENAGITK--------QQLQG--STTGVYV---------------------------------------G-SMNSDY--RGLF-TS-----------S----A--S-QVGSYTATGISNSIISARLSYVYDLRGPS------MTIDTACSSALVSVHLGAQAIRAGDCDVAICGGTNCLMLP-DVFVHLSKSHMLSPTGQCHTFSGDAD--------------------------------------------------------------------GYTRGEGCGILILKRLR-D--------------A--ERDGDNIWA-TVL-TGTN--QDGRAVS-------P---MTAPSMDQQIKLLEHIYAS-P-AVSV-DNIDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPIEANAVG-LFFK-DH---S-T--T------------------------------------------------------------P-----R-TRYIGSVKSN-LGHLESAAGAVAMIKVMLMMRHSRIVPSLH-FS-PD--N--PNPRID-FEGLQLQVPT--EVI-DWPT--K-------NKIACASSFG-FGGTNSHAVMIEYI----KP--T-P------D---T-SC---------VD----------TQE-----K-R------PCIVCFSANSDKSL---Q-------------------- 453 ------------------------VAIVGIGCRTP-G-A---DNIRDFWRVLV-NGECHV-TDVP-E--D-RW-NSSA--YLNT---EHRLAHGKA-YVQKGGFI-----K-D--IE-AFDNALYGISDI-EASKMDPQQCLLLDCTVMALQDAGITR--------EEIAG--SNTAVFV---------------------------------------G-AMNSDC--SAGF-VG-----------C----T--S-KVDNYTATNIGTSIMANRVSHVFDLRGPS------MVLDTACSASLIAIHLGCQAILSGDSDMAICGGVNVMTLP-DMFVHLSKAGMISPSGLCHTFSKNAD--------------------------------------------------------------------GYTRGEGCGVVILKRLR-T--------------A--QRKGDKLWA-TVS-TGTN--QDGREER-------L---LTNPSGVQQKKLLESVYSK-S-DVSV-DDVDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEVNALG-SFFK-KH---G----R------------------------------------------------------------P-----R-DRYVGSVKTN-IGHTESAAGVLSIIKVLLMMKHGKIVPSLH-CA-VD--E--VNPDID-LAGLGLNIPR--VAV-PWDN--E-------NKTAGCNSFG-FGGSNCHAVLKSAK----QR--V-----------------------------------------------------------------------K-------------------- 454 ------------------------VAIIGVGCKFP-G-A---DNLEEFWKLLE-NGENHV-IEIP-D--S-RW-LHDS--VYD----NDFNTPGKT-HARKAGLL-----T-D--HL-AFDNKLFNIKDV-EADIMDPQQRYVLECCHRALEDAGITR--------NQIKG--SNTCVFI---------------------------------------G-AMNTDY--RSEF-SS-----------E----S--F-VPDNYAVTGISNSLISNRVSYIYDLRGSS------VTIDTACSSSLIAIDWGIQALRAGKCDMVICGGVNSILTP-DSFVHLSKARMISAKGQCFAFSDQVD--------------------------------------------------------------------GYTRGEGCGVVILKRLR-D--------------A--IQDENNVWA-TIE-TGCN--QDGGTVS-------P---ISKPSVEQQVQLLQAVWAK-S-AIDT-NRLTYIEAHG-----------------------------------------------------------------------T-GTPV------G------DVIEVKSLG-KFFQ-NT--Q-----T------------------------------------------------------------V-----RP-RFIGSVKTN-IGHLESAAGVAGLIKVLLMMKHSKIVPSLH-FQ-RP------NPDID-FEGFQLKVPT--EVA-DWPD--T-------DKVASVSSYG-FGGTNCYAIIECHQ----Q---------------------------------------------------------------------------S-------------------- 455 ------------------------IAIVGIGCRMP-GDV---NSPEAFWDVLV-QGRNVL-SEVP-P--E-RW-SLEA--YYN----PDPASLGTH-VNTRGGFIR------D--MD-RFDNGFFKISPK-EAAMMDPQQRHLLEVTHEAFEDAGIET--------ERLGA---RCGVYV---------------------------------------G-IGMMDY--PLML-GP---D------------S--T-NFNAYAHTGVAHSVAANRISFAFNLQGPS------VAVDTACAASMTALHFGCQALWNNECGVSVVAGSNVLLMP-EVTAGFSALSVLSPEGQSRPFDINAK--------------------------------------------------------------------GYVRSEGFGAIIIKPLA-Q--------------A--LKDGDNIYC-TILGSGIA--SNGATP--------S---ITMPSCDAQVRLMQSVYEQ-F-KIDS-DRLIYVEAHG-----------------------------------------------------------------------T-GTPV------------GDPMEAEAIG-RALA-TE--R------------------------------------------------------------------P-----E-ALRIGSAKSN-FGHMECCAGMVSIIKTALMLKHRQLCPSIN-FT-A------PIDDR--FKDWNIDVQT--KME-DFPA--G------RNHLIGVNNYG-FGGALAHAVLAEVP----FE--T-K------T---R-EQ--PR-D-QR---PK-----------------------------------------L-------------------- 456 ------------------------IAVVGVGGRFP-G-A---KDVDQFWRLLL-NKENHV-KDI-PP--D-RW-NNDA--FYD----ANPDVPGKT-YVKKAGLL-----D-D--HD-VFDNRLFGINDL-EAERMDPQQHYVLECTHMALENAGITR--------AKIAG--SRTGVYI---------------------------------------G-AMNQDC--NAAA-QY-----------D----G-CV-SCNSYSVTGPTGSILAARVSYVFDLRGPS------MVVDTACSSSLVALHLAIQGILSGDCDMAICGGVSSILLP-NFFIVLSRARMLSPSGQCQAFSQTAD--------------------------------------------------------------------GYARGEGCGVVILKRLG-QAVR----------------DGDHIWG-VVLGTLCN--QDGRTAT-------P---LTSPSGAQQVNLLRDVYSK-F-KVNP-RDVTYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEVNALG-QFFG-ST--D------------------------------------------------------------------R-----P-PLPIGSVKTN-IGHLEPAAGMAGLIKVLLMIRHKQYVPTVL-FS-----D--LNPRLD-FSGYGFKVCV--DVS-DWKV--S-P--G-QLRIASVNSFG-FGGTNSHAIVQEYM----PS--T------A-E------------K---------R-SF-AA-------E--------------P------------------------------- 457 ---------------------------------------------------------NHL-NPIDPQ--Q-RW-SEDA--FYN----PDPDHPGTS-YTKHAGLL-----T-D--YD-KFDNRFFGINDL-EASRLDPQQRYALECTHMALENAGLTR--------EAVAA--SRTGVFI---------------------------------------G-VMNVDY--GRLC-TQ-----------D----L-T--ATNAYTVTGCSGSLIANRVSYVYDLRGPS------LVLDTACSSSLVAIHLGVQALRSGECEMALCGGVNSILLP-DVHVLLTKTRMTSPTGQSQAFSDTAD--------------------------------------------------------------------GYARSEGCGMVLLKPLA-KALQ----------------DGDRVWA-VV-GSGSN--QDGRSAT-------P---ITAPSASQQVNLLQQVYQR-W-QVDP-DLVDYIEAHG-----------------------------------------------------------------------T-GTPL------G------DPVEIRALG-EFFG-EP--D------------------------------------------------------------------R-----P-RL-VGSLKTN-VGHLESAAGVAGLIKLLLMIQHRQVVPTLL-FS-----S--LNPKLQ-LDSYGFQVAT--SVT-EWSV--A-E--G-KPRVACVNSFG-FGGSNGHMVVQEFL----PR--R------Q-Q---------AE-E-SQ---PQKH-VV-AF-------SGT-------TRESLQ------------------------------- 458 --------------------------ITGVGLRLP-H-A---DNLEELSKLLL-NQCSAL-G--E-P----RW-QPH---LFG--------------MDQQCGLIA------S--AG-MMDCNLFNISP-EEASYCSPVLGPLLEVVTECILDSGLKL--------SDVAKH--RTGFYL---------------------------------------G-VTSCDT--DTV-MT---------------------GSTDSSSSFLNTRTELCARVAHQFDLRGPV------LQLDGANASSFAAIHAALMDLKTERCDIAIVAGCNLVLDP-IVSFQLAKLNILSPRGEDSLFDGAAH--------------------------------------------------------------------GYVRSEGIIALLLLSST-A--------------DITTR----TYCD-IVGFGLC--CNGAMDN-------G---LLYANHKSQAELLTDVYT-K-HNIDV-NDIVYYEAAG-----------------------------------------------------------------------A-S-QK------G------GQAELTAII-ESVC-KK--R------------------------------------------------------------------H-----K-PLIVGSISGN-VGHTEATAGLAGIVKCLASYRTQTIFANVN-VN-----Q--TDSSISSLKTGNIVIPT--SNS-PWPE----D----KTGLMSVSSIG-FGGLMGHIVLKPRP----------------------------------------------------------------------------------------------------- 459 ------------------------VAISGISGRLP-E-S--A-NVAEFRDHLM-KKEDMT-TE---DNR--RW-EV-------------GL-Y--G-LPPRNGKVK--------ELQH-FDAAFFGVHPK-QADCMDPQLRMLLEVSYEAIIDAGQTL--------ESVRGS--KTGVYV---------------------------------------G-ASTSDA--SEAW-SI---E------------A--E-TTVGYTMPGCCKAMFANRISYFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALLNIRMGMIDSAIVAGTNLCTKPCTSLQFTRMGMTSPT-GYCKTFDASGDGYCRSEAIMAIFLQKTA-D--------------C--RR----IYA-TVVHTKAN--CDGFKEQ-------G---VTFPSGLAQKQLINEVYHE-I-GISP-LDIAYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINSIV-DVFC-K--G---R----------------------------------------------------------------E----G-PLLIGSTKSN-MGHPEAASGLTSIAKILISMEENVIPPNLH-Y---K--T--PNPEIPGLVDGSLQVVT--ECT-RWNG-----------GLVAMNSFG-FGGANVHAIFRSH--N--KE--S-V------E----PHV--AS-Q-------------------------K------PRLFTCSARTEEGVKAVL-------------------- 460 ------------------------IAIVGIGCRTP-G-A---DNIQEFWKLLV-NGECHV-TEVP-H--D-RW-NSQV--YYD----PDPMAVGKA-YVKRGGFL-----D-N--PT-GFDNALYGINNF-EASEMDPQQCLLLDCTIMALEDAGITR--------AQISG--TNTGVFI---------------------------------------G-AMNSDA--RSSA-MG-----------Y----T--S-RITSYTATGKSLSFMSGRLSYVFNLQGPS------MVVDTACSAALVAVHLGCQAILSGDCDMAVCGGVNSMTTP-DAFVHLSKAKMISPTGLCHTFSDKAD--------------------------------------------------------------------GYVRAEGCGIIILKRLP-D--------------A--EREGSKIWA-TVC-TGTN--QDGHAVS-------P---MTAPSGEQQKKLLHSVYSK-F-QLDV-SLLHYIEMHG-----------------------------------------------------------------------T-GTPA------G------DHVEVNACG-QFLK-EK---G----D------------------------------------------------------------I-----R-QRYIGSLKTN-IGHTESGSGVLSVIKVVLMMHNEIIVPSLH-C---D--S--VNPKID-LADLMFVVPK--TAV-QWPT--K-------LKVAGVNGFG-FGGSNCHAVLSSYA----KR--V-D----------A------E-K-G-------------GER-----Q-L------PCIVCVSGNTKKSL---R-------------------- 461 --------------------------IGGIACRFPQ--S---DDVQEFWSNLE-SGKDMI-V-------STRW-PPK---LHG--------------LPPRSGCIK------D--LSL-FDAKFFGIKSRQETHEMNQLLRLLCEVTYESIVDSGITL--------DTLQKE--VVGFYL---------------------------------------A-CTFSDT--DVV-TS---------------------SQK-LKANKLHNGSTLVSSLMSTFNLRGPT------CSIDTACSSSFSALHTACRDLEMGLCKYAIVAGANIIDNP-NCSLKFHRLSMLSPTGTSNVFDKSAN--------------------------------------------------------------------GYVRSDGVAALLLTRDE-D----------------LPR----IYAS-IANIGVN--CDGFKEE-------G---IIYPSQTSQANLLKQLYQ----DRST-NDIAYVEAHG-----------------------------------------------------------------------T-GTQA------G------DTIETTALA-SVLC-KN--R------------------------------------------------------------------K-----K-PLIVGSVKSN-MGHCEATAGLAGLIKCLLSIHYGKIPGNLN-FK-----I--PNPAIGVLSSGEIKVVD--TMT-ELPD----G-------VIGINCFG-FGGVNGHAIIKPYR----KQ--I-D------H---K--D--K----N------------------------------IRLMLISARTTDMM---E-------------------- 462 ------------------------VAISGMSGRLP-E-S--A-NIEEFKEHLM-NNEDMV-TE---DDR--RW-EV-------------GF-Q--G-LPPRNGKLK--------DVER-FDAAFFSVHAK-QSLSMDPQLKILLECTYEAIIDAGKSL--------QEVKGS--RTGVFV---------------------------------------G-VSTADC--GDTW-TE---D------------F--E-NINGYAIVGSAKNMFANRLSFFFDFRGP------S--------------------------------------------------------------------VIVDTACSSSAYCLTQALCFMRMGVIDSAIVAGSNLLMKAALSLQFLTLGVLSPD-GSCKAFDASANGYCRSESIMAIYLQKVP-D--------------C--KR----IYA-TLVHSKSN--SDGYKEE-------G---VTFPSGIQQQNLIKEVYHE-C-GINP-LDVSYVEAHG-----------------------------------------------------------------------T-GTHV------------GDPQEVNSIA-GFFC-K--G---R----------------------------------------------------------------K----E-PLLIGSVKSN-MGHAEACSGLNAIAKIIIAMENQMIPANIH-F---K--N--PNPGIQGLIDGSLKVVD--ENT-RWKG-----------GLVAMNSFG-FGGSNVHCLFKSH--Q--KE--L-K------E----PHP--AS-Q-------------------------K------PRLFTYGGRTEEGVQAVL-------------------- 463 ------------------------VAISGISGRLP-E-S--D-SVAEFREHLL-NKEDMV-TA---DDR--RW-TV-------------GL-N--G-LPPRCGKIK--------ELSH-FDAGFFGVHPK-QANCMDPQLRILLEVAYEAIIDAGQSL--------DSVRGS--RTGVYI---------------------------------------G-VSQSEA--SDAW-SL---D------------A--E-TLVGYTMPGCCRAMFANRISYFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSTMCLDQALMSIRMGLIDSALVGGTNLCLKPNTSLQFTRMGMTSPD-GKCKTFDAKGDGYCRSEAIVAIFLQKTA-D--------------C--KR----IYA-TVVHSKSN--CDGYKEQ-------G---ITFPSGELQKQLVNEVYHE-I-GINP-LDIAYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQETNSIV-DVFC-K--G---R----------------------------------------------------------------N----G-PLLIGSTKSN-MGHPEPTSGLSSIAKIIVAMEERVIPPNLH-F---E--T--PNPEIPGLTDGSLQVVT--ECT-PWNG-----------GLVAMNSFG-FGGANVHTIFRSH--D--KE--L-T------E----PHV--AS-E-------------------------K------LRLFTCSARTEEGVKKIL-------------------- 464 ------------------------IVISGISGRLP-E-S--E-NIEEFRQHLI-LGEDMV-TD---DDR--RW-EPGL--------------H--G-LPPRSGKLK--------DISK-FDATYFGVHPK-QADAMDPQLRILLEITQEALVDAGVNP--------NSIRGS--RTGVFI---------------------------------------G-VSTSDA--GEAW-SA---D------------P--E-KLVGYSMTGCCRAMFANRLSYFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSMLAFDEALHNIRMGHCDAAIVGGSNLCLKPTSALQFLKLGMLSPD-GSCKSFDESGNGYCRSEAIVAIFLQKKS-V--------------A--RK----ILS-SVIHSKTN--SDGSKEQ-------G---ITFPSGAVQKELLQEVYQE-C-GISP-SKIAYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNSIT-DVF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 465 ------------------------VAIIGIACKTA-G-A---ENIRDFWRILF-NGENHI-TDVP-A--S-RW-NAEA--FYD----KDPTKQGKT-HVTKAGFV-----T-S--IE-DFDNGFFGINDF-EVASMDPQQRFVLECTHMALEDGGLTR--------AKVSG--SNTGVFI---------------------------------------G-AMNADH--SCLY-NA-----------G----S----QVDMYGVTGVTNAILAARVSYVYNLLGPS------MVIDTACSSALVCIHAGAQAIRNGECDMAVCGGVNYMGTP-ALFVQLSKSAMISADGQSKAFAADAN--------------------------------------------------------------------GYARAEGCGIVILKRLR-D--------------A--IKDNDNIWA-TVV-SGIN--QDGRMVT-------P---MTSPSGKQQVELMRHIYQK-F-SVDA-SKIDYIEAHG-----------------------------------------------------------------------A-GTQA------G------DPVEANAVG-TFFK-EA---A----P------------------------------------------------------------P-----R-TRYIGSVKTN-VGHLESASGAIGVIKVLLMMKYNTIVPSLN-C---R--E--VNPRIN-QEELGLIIPR--KPV-AWDK--S-------QKMACVNSFG-FGGTNCHVVLQTIP----PV--E-T----------K------P-T-S---------------K-----H-D------LGIVCFSGKTMLSL---R-------------------- 466 ------------------------IAIVGIGVKTS-G-A---DNIRDFWRLLQ-NGENHI-KEVP-A--S-RW-NPNA--FYS----DDHTKPGKA-YVKKAAFI-----N-D--AE-KFDNAFFEINDF-EAASLDPQQTFVLECTHMALEDAGLTR--------AQISG--SKTGVFI---------------------------------------G-AMNPDH--ASSF-LA-----------G----S--G-EVDSYTATGVSTSVLSARVSYVYNLLGPS------MVIDTACSSSLVCIHQGIQAIRNGDCDMAICGGVNYMGSP-TMFIQLSKTKMLSPTGQSKAFSADAD--------------------------------------------------------------------GYARGEGCGIVVLKRVK-D--------------A--LKSHDPIWA-TIV-SGVN--QDGHTVT-------P---MTAPSGIQQKTLLRDIYTK-F-RIDV-SKLDYIEAHG-----------------------------------------------------------------------T-GTQA------G------DPVEANAIG-NFLK-EV---G----E------------------------------------------------------------P-----R-KRYIGSVKTN-VGHLEAAAGVAGVIKVLLMMKHSAIVPSLH-C---Q--Q--VNPLID-LENLGLVIPQ--SVV-EWES--K-------HKVACCNSFG-FGGTNSHVVLTEFS----HE--K-C----------Q------I-P-E---------------K-----P-C------PKIVCFSGKTKQSVL--R-------------------- 467 ------------------------IAVVGIGCKVP-G-A---RNIRDFWRLLV-KGENHI-VEIP-A--S-RW-NADA--AYD----PDPMAPGKC-YVKRAGLV-----S-G--WD-EFDNKLYGINDF-EAPQMDPQQRFALDCTFMALQDAGLTR--------AQIAG--SNTGVFI---------------------------------------G-AMNADY--RGLF-TA-----------Q----S--S-NIGNYTVTGISNSIIAARLSYVFDLRGPS------LVLDTACSSSLIAIHLGCQAILTGDCDMAICGGVNYLTLP-DVFVHLSKARMISPSGQCHSFSTKAD--------------------------------------------------------------------GYTRGEGCGIVIIKRLR-D--------------A--ERDGDNIWG-TIY-TGSN--QDGHAVS-------P---LTAPSGLQQIRLMDHVYRK-T-GLDI-SAVDYIEAHG-----------------------------------------------------------------------T-GTGA------G------DPVEVNSLG-EYFQ-QN---A----S------------------------------------------------------------A-----R-QRYIGSVKTN-IGHLESAAGVVGVIKVLLMMKHGKIVPSLH-FD-----E--PNPKIR-FQEFHLKVPT--TPV-EWTN--P-------DKVSCCNSFG-FGGSNSHALIKQYR----KP--E-G------D---K-TA---------VVTE--------SQL-----Q-R------PCVVCFSAVTAKSLR--G-------------------- 468 ------------------------IAIIGIGCVTP-G-A---DNLDEFWRVLV-NGENHV-IDIP-P--E-RW-NGQA--YYH----PDPMVPGKS-YVRRAGLI-----R-A--PD-EWDNRLFNVNDF-EMNQMDPQQRLVLDCTYMALENAGLTR--------AGLAG--SDTGVYV---------------------------------------G-AMNSDY--RGLF-TA-----------A----S--T-IVGNYTATGVSNSIIAARVSYIFDLRGPA------VTVDTACSSALVSIHFGAQAIISGDCNLAICGGTNYLTLP-DVFVHLSKAHMLSPTGQCHAFSDKAD--------------------------------------------------------------------GYTRGEGCGILILKRLK-D--------------A--ERDGDNIWG-TIV-TGCN--QDGRTVT-------P---MTAPSLPQQTKLLEQIYRQ-A-NVDI-DRLDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPIEATAVG-SFFK-DH---S-T--V------------------------------------------------------------S-----K-VRFIGTVKTN-IGHLESAAGAVGIIKVLLMMRHGLIVPSLH-FA-NN--N--PNPRID-FQELQLQVPT--EVT-EWRS--E-------NKIACVNSFG-FGGTNGHCILIEYT----QR--Q-A------Y---S-TA---------LE----------VTA-----K-K------PCIVCLSANSDKS----L-------------------- 469 ------------------------IAIIGIACKTA-G-A---ENIRDFWRILI-NGENHI-TDIP-A--N-RW-NAEV--FYD----KDPMKQGRT-HARKAGFI-----T-S--AE-DFDNGFFGINDF-ELASLDPQHRFVLECTHMALENSGLTR--------ANISG--SNTGVFI---------------------------------------G-AINSDY--SSVY-NA-----------G----S----QVDMYGATGMSNSILAARVSYVYNLLGPS------MVIDSACSSSLVCIHAGAQAIRNGECDMAICGGVNYLGTP-ILFVQLSKSAMISADGQSKSFSADAD--------------------------------------------------------------------GYGRADGCGIIILKRLR-D--------------A--IKDKHNIWA-TVV-SGVN--QDGRMVT-------P---MTSPSGKQQVELLRHIYRK-F-SVDA-SKIDYIEAHA-----------------------------------------------------------------------A-GTQA------G------DPVEANAVG-TFFK-EA---V----P------------------------------------------------------------P-----R-TRYIGSVKTN-VGHLEGGSGVIGLIKVLLMMKYNTIVPSLN-C---R--E--VNPRIN-LEELGLIIPR--KPV-AWDK--A-------QKMACINSFG-FGGTNCHVVLQTIP----RV--Q-T----------K------P-T-S---------------K-----R-D------LGIVCFSGKTPLSL---R-------------------- 470 ------------------------IAIVGIGVKTP-G-A---DNIRDFWRLLQ-NGENHI-KEVP-A--S-RW-NPDA--FYS----EDPTEPGKA-YVKKAGLI-----K-N--AQ-QFDNAFFEINDY-EAASLDPQQSFVLECTHMALEDAGLTR--------SQISG--SKTGVFI---------------------------------------G-AMTADH--ASSF-SM-----------G----S--G-EVDDYTATGVSNSLLSARVSYVYNLLGPS------MVINTACSSSLVCVHQGIQAIRNGDCEMAICGGVNYIGSP-DLFIYLSKSKMLSPTGQSKAFSAEAD--------------------------------------------------------------------GYTRGEGCGIVILKRVK-D--------------A--LKNNDPIWA-TIV-SGVN--QDGHTVT-------P---VTAPSGIQQKALLRDIYTK-F-AVDV-SKLDYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPVEANAIG-NFLK-EW---G----E------------------------------------------------------------P-----R-ERYIGSVKTN-IGHLEAAGGVAGVIKVLLMMKHDTIVPSLH-C---Q--Q--VNPDID-LESLRLVVPQ--SLV-KWES--K-------EKLACCNSFG-FGGTSSHVVLKQFR----HT--K-C----------Q------T-S-E---------------K-----P-C------PKIVCFSGKTKQSVN--R-------------------- 471 ------------------------IAIVGIACKTP-G-A---ENIRDFWRILV-NGENHI-TDVP-V--T-RW-NAEA--FYD----KDPTKQGKT-HVRKAGFV-----T-S--IE-EFDNAFFGINDF-EIASMDPQQRFVLECTHMALEDGGLTR--------AGVSG--SNTGVFI---------------------------------------G-AMNADH--SFLY-NA-----------G----T----QVDMYGVTGVTNAILAARVSYAYNLLGPS------MVIDTACSSALVCIHAGAQAIRNGECDMAICGGVNYIANP-AMFVQLSKSAMISGEGQSKAFSADAD--------------------------------------------------------------------GYARAEGCGIVILKRLS-D--------------A--IKDNDNIWA-TVV-SGTN--QDGRMVT-------P---MTSPSGKQQVELMRQIYQK-F-SVDA-SSVDYIEAHA-----------------------------------------------------------------------A-GTQA------G------DPVEVNAVG-TFFK-EA---A----P------------------------------------------------------------P-----R-TRYIGSVKTN-VGHLESASGAIGVIKVLLMMKFNTIVPSLF-C---R--E--VNPRIN-LDELRLMIPQ--KPV-AWDK--T-------EKIACVNSFG-FGGTNCHVVLQTVP----RV--E-K----------K------P-T-S---------------R-----R-D------LGIVCFSGKTNLSL---R-------------------- 472 ------------------------MAIVGIGCKVP-G-A---ENIQEFWRLLL-KGENHI-VEIP-S--T-RW-NADA--CYD----SDPMALGKS-YIMRAGLV-----S-R--PD-EFDNKLYAINDF-EAAQMDPQQRFVLECTTMALEDAGITR--------AQLAG--SNTGVFM---------------------------------------G-VMNTDY--RAVF-TA-----------Q----C--S-TIGNYTVTGISNSVIAARLSYVLDLRGPS------LVLDTACSSSLVAIHLGCQAIRTGDCDVAICGGVNYFGLP-DIFVHLSKARMISPSGQCHSFSHHAD--------------------------------------------------------------------GYTRGEGCGVVILKRLR-D--------------A--VRDGDNIWA-TIY-TGVN--QDGHTVA-------P---ITAPSGLQQVRLLEQIYGN-L-DLDV-SAIDYIEAHG-----------------------------------------------------------------------T-GTVA------G------DPVEVNALG-EYFK-GK---T----T------------------------------------------------------------P-----R-TRYIGSVKTN-IGHLESAAGVVGIIKVLLMMKNQKIVPSLH-CD-----V--PNPKIR-FDEFLLNVPK--EVV-DWSN--P-------VKMACCNSFG-FGGTNSHVLLQFYK----KP--A-R------P---T-EN---------------------SRV-----R-K------PCIICFSAMSHKSLRAMM-------------------- 473 ------------------------VAIVGIGAITP-G-A---DNIRDFWRLLK-NGENHI-TDVP-A--S-RW-HADA--FYD----SDPMKPGKA-YVKKAGFV-----K-D--VE-KFDNVFFEINDY-EAASLDPQQSLVLECTHMALEDGGFTR--------TQMAG--TNTGVFI---------------------------------------G-AMTSDH--SIFY-LA-----------G----S--P-GVDSYTATGISNSMLAARLSFSYNLLGPS------MVIETACSSSLVAIHQGIQAIKNGNCDMAICGGVNYIGAP-GMFIHLSKTKMLSPTGQCRAFSADAD--------------------------------------------------------------------GYVRGEGCGIVVLKRLK-D--------------A--LDNNDRIWA-TVV-SGVN--QDGHTVT-------P---VTAPSGPQQEKLMRDIYTK-Y-GVDV-SRLDYIEAHG-----------------------------------------------------------------------T-GTQA------G------DPVEANALG-KFLK-SM---D----Q------------------------------------------------------------P-----R-TRYIGSVKTN-IGHLEAAAGVVGVIKVLLMMKHNTIVPSLH-C---Q--K--VNPLID-LENLGLVIPQ--SLV-EWKS--K-------EKMACCNSFG-FGGTNSHVVLQTFS----NS--K-S----------L------I-L-E---------------K-----Y-R------SNVVCFSGKTKQSL---K-------------------- 474 ------------------------VVISGISGRLP-E-S--N-NMEEFRQHLM-LGEDMI-TE---DDR--RW-PPGL--------------Q--G-LPAGMGKLK--------DISK-FDAAFFGVSPK-QADLMDPQVRMLMETTYECIVDAGVNP--------QSLRGS--KTGVFI---------------------------------------G-ASFSEA--AEAF-AG---D------------T--D-KNIGYALTGCCRAMFANRLSFFFDLRGP------S--------------------------------------------------------------------FTIDTACSSSMLALDQALHSIRMGHCDAAIVGGSGLLLKPASSLQFMQLGMLAPD-GRCKSFDASGNGYVRSEAVSTIFLQKAS-D--------------A--KR----VYA-TVVHSGTN--TDGNKEK-------G---ITFPSGEVQKQLLQRVYSE-V-CISP-ASVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEANAIT-DVFC-K--G---R----------------------------------------------------------------Q----G-PLLIGSTKSN-MGHAEPASGLASVAKVLIAMEDGMIPPNLH-Y---S--Q--PNTDIPGLVDGRLEVVT--KRK-RWEG-----------GYVGINSFG-FGGANVHTILKSC--D--KK--R------T-I----SHP--NE-N-------------------------N------CRLFTYAGRTEESVKQAF-------------------- 475 ------------------------VVIVGVGCRLP-G-A---DNIDEFFKLLQ-NGENHV-VEVP-K--N-RW-NVDK--FYD----SDALTPGKT-NVRKAGFV-----G-G--IE-KWDYKLFGINEL-ESQRMDPQHKLALDCVYMALENAGITK--------KSIKG--SNAAVFI---------------------------------------G-VMNSDY--SG-L-TS-----------T----A--T-DFDNYTVTGTNNSIISSRINYTFDLHGPS------LCIDTACSSSLMAIHQAHQAILSGECDMAIAGGVNLILSP-SIFIQLTKAGMVSPTGQSQAFSENAD--------------------------------------------------------------------GYARGEGCGIVILKSYK-K--------------A--MEDNNPIWA-TIS-TASN--HDGHAVS-------P---ITSPSMEQQMQLLDIAFTR-F-NVDP-QSIDYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPIEVEALG-RYFH-----------------------------------------------------------------TTDNN--S-----S-PKLLGSVKTN-IGHLESAAGVAGLIKVLLMHKHQQIVKSLH-FV-----R--PSPEVP-LEKYNLRVAV--NLQ-PWPE--SD---R-EILRSSVNCFG-FGGSNCHAIVTTQK----SI--P-N------H---Q-SN--TN---LI--YHP-------------------------KVVCLSAVDTVSLQM-I-------------------- 476 ------------------------IAIVGIGCKVP-G-A---DNVEQFWRVLE-KGENHV-VDIP-K--S-RW-DNDA--YYD----TDLHAVGKS-YVKKAGLL-----Q-D--PK-AFDNKLFNINDF-EADQMDPQQRFVLECCHMAMEDAGITR--------DNLAG--SNTGVYV---------------------------------------G-AMNGDY--RALF-TA-----------K----S--P-IVGNYTVTGVSNSIISARVSFIFDLRGPS------LTLDTACSSALVAIHLGAQALRTGDCDQALCGGTNFLMSP-DVFVHLSKAHMVSPTGQCFAFSDSAD--------------------------------------------------------------------GYTRGEGCGMVILKRLK-D--------------A--IRDGDNIWA-TIE-TGSN--QDGHTVT-------P---ISAPSGEQQIKLLEHVYRN-S-KLDL-DKIDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVETKALG-TFFS-SY---G----A------------------------------------------------------------T-----R-TRYIGSVKTN-VGHLESAAGTAGIIKVLLMMKHSKIAPSLF-FD-----R--PNPRID-FPDLNLQVPT--EVI-DWPT--H-------KKVACVNSFG-FGGTNCHALVKSYS----DT--S-L----M-R---R-TS---------QF----------EGM-----S-I------PCIVCFSGKHEKSL---R-------------------- 477 ------------------------MAIIGVGCKLP-G-A---DNLEEFWSLLE-NGENHV-TEIP-E--T-RW-FHES--VYD----PDFNTPAKT-HARKAGLL-----K-D--HL-AFDNKLFNIKDV-EADIMDPQQRYVLECCHRAQEDAGLTR--------DQLSG--SNTCVFI---------------------------------------G-AMNTDY--RSQF-NS-----------T----S--F-ETDNYSVTGMAGSIIANRVSYIYDLRGPS------VTIDTACSSSLVAIDMGLHYLRAGTCDMAICGGVNSILTA-DLFIHLSKARMVSAKGQCFAFSDQVD--------------------------------------------------------------------GYTRGEGCGVVILKRLQ-D--------------A--KRDKNNIWA-TIE-TGCN--QDGGTVA-------P---ISKPSEEQQIKLLQAVWDR-S-RADP-GDLFYIEAHG-----------------------------------------------------------------------T-GTPV------G------DVVEVNALG-TFLQ-GT--H-----T------------------------------------------------------------G-----NV-RYIGSVKTN-IGHLESAAGVAGLIKVLLMMKHSMIVPSLH-FQ-RP------NPNID-FHGFHLKVAT--EVI-SWPE--P-------RKVASVTSCG-FGGTNSYAIIESQG----QP--G-R------A---K-P----D-M-P-----------------------S------ENIVCFSAMNLESL---K-------------------- 478 -------------------------AVCGMGCRFPL--S---ENIQEFWDNLQ-SGKDMV-G-------STKW-PKG---LHG--------------LPPRSGNCK------N--IRENFDAKFFGINTQEDADESNVLLRPLLEVTYECIVDSGIRL--------DKLQKE--KTGYYL---------------------------------------A-YSVCDS--DAV-ET---------------------SKD-VHRNKVNNGSSIIGSLVSHFGLTGPC------KTIDTACSSSLSILTSACLDLEQNRCQYAIIAGSNIVDNP-YYSLRFLRLGMLSPLGTSNVFDKSAN--------------------------------------------------------------------GYVRSDGVAAILISRNE-V---------------DLPR----IYAT-IVDVGVN--CDGYKEE-------G---IVFPSTSSQANLLKTLYR----NIST-NDIAYIEAHG-----------------------------------------------------------------------T-GTQA------G------DKSESNSLA-TVLC-EG--R------------------------------------------------------------------S-----K-PLLVGSVKSN-MGHCEEAAGMAGMVKCLLSIHNGKIPGNLN-YN-----T--PNPDIPQLHNGQLSVVH--KTI-DLPD----G-------LVGANSFG-FGGVNGHVIF--------------------------------------------------------------------------------------------------------- 479 ----------------------------------------------------------------------------------------------------------------------------------------------------EALVDAGVNP--------VSIRGS--RTGVFI---------------------------------------G-VSTSDA--GEAW-SA---D------------P--E-KLVGYSMTGCCRAMFANRLSYFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSMLALDEALHAIRMGHCDSAIVGGSNLCLKPTSALQFLKLGMLSPD-GSCKSFDEEGNGYCRSEAIVAIFLQKKS-V--------------A--RK----VLS-TVIHSKTN--SDGAKE-----------------------LLQEVYSE-C-GVAP-SKVSYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNSIT-DVFC-K--D---R----------------------------------------------------------------K----E-PLLIGSTKSN-MGHPEPASGLAAIAKVIIAMEDGMIPANLH-Y---H--N--PNPDIPGLFDGRLKVVS--ERT-RWNG-----------GYVGVNSFG-FGGANVHAVLKS------------------------------------------------------------------------------------------------------- 480 ---------------------------VGVGCRFP-G-A---DNVDEFWRVLR-NGENHV-IEIP-P--N-RW-NLEA--FYD----PDPTVPGKT-HVRRAGFV-----D-G--HD-KWDFKVYGVNEF-EALKMDPQHKFVLDCTFMALENAGISK--------QQISG--SNTGVYI---------------------------------------G-MFGSDY--SNIY-AT-----------I----A--E-ESDNYTLTGCSDSIVAARVSYVFNLYGPS------MKIDTACSSSMVAIHLACQALRSGECDMAIAGGVNSLMKP-DIFIQLSKAGMVSPTGQCQAFSENAD--------------------------------------------------------------------GYARGEGCGIIILKPLE-Q--------------A--LNDNDPIWA-TIV-TSVN--HDGQTVT-------P---ITTPSPQQQESLLDTIFDR-Y-GIDP-ETVDYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPVEVTALG-KFFQ-----------------------------------------------------------------KD-KN--P-----K-QRLIGSVKTN-IGHLESGAGVAGLIKVLLMHKHQEIVPSLH-FD-----K--PSENVP-LEKYNLKVPT--EVH-PWPQ--ND---N-GYMRSCINSFS-FGGTNSHAIITTPM----HP--S-N------E---P-EN-------------------------------------------------------S-------------------- 481 ------------------------IAIIGVGCKLP-G-A---DNIDQFWRVLE-NGENHV-LEVP-S--D-RW-NLDA--FYD----PDPNAPGKT-YVRRAGFI-----K-N--HD-AWDNKVYGVNDF-EASQMDPQQRFVLDCCFKAMENAGVTR--------ESMHG--SNTGVYV---------------------------------------G-VMNSDY--KNLQ-ST-----------D----S--E-NMNNYSLTGTSTSIVAARISFTFNLLGPA------MALDTACSSSLLAIHLAAQALREGDCDMALAGGVNSLMSP-SIFVQLSKARMASPTGYCQAFSSKAD--------------------------------------------------------------------GYARGEGAGIILLKRLK-D--------------A--ERDNDPIWG-TIM-TGSN--QDGHTVT-------P---MTAPSGSQQFQLLKKVYSR-Y-NIDP-DQLEYIEAHG-----------------------------------------------------------------------T-GTQA------G------DPVEANCLG-GFLA-----------------------------------------------------------------DH-TK--N-----A-PRYIGSVKTN-IGHLESAAGVAGVIKVLLMQKHSLIVPTLH-FD-----T--PNEKID-FDKLKLIVAT--RTD-KWPT--YNY--D-GTKLSCVNSFS-FGGTNCHAIIKSYN----T---A-K----A-V---K-VV--D-----P--DKL-------------------------RLICFSGVDEISV---K-------------------- 482 ------------------------VAIIGVGCRVP-G-A---NNIDEFWNLLK-NGENHV-IEIP-P--E-RW-NLEA--FYH----PDQGAPGKT-YAREAGLL-----K-D--HD-KWDYKIYGINEF-EAKKMDPQHKYVLDCTFMGFENAGITR--------DMVDA--SRTGVYI---------------------------------------G-LMGSDY--SSVF-YG-----------D----Y--N-DFDNYTLTGINNSIVSSRVSYVFNLHGPS------VKLDSACSSALLAIHLACQSIRLGETDMAVAGGVNAILSP-DTFIQLSKAGMVSATGQCHAFSENAD--------------------------------------------------------------------GYTRGEGCGIVILKKYE-Q--------------A--IKDNDPIWA-IID-TASN--HDGSSMK-------P---ITNPSKELQKRLLQDIFDR-T-NTDP-QTIDYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPVEIAALG-EFFH-----------------------------------------------------------------DP-NR--P-----K-QRFVGSVKTN-IGHLESAAGVAGLIKVLLMHKHQMIVPSLH-FE-----K--PSENVP-LHSYHLDVPT--KLY-QWPQ--VD---R-DNLKSSLNSFG-FGGSNCHAIITSYR----SS--K-K------P---D-DQ--IK----S--RGP-------------------------RICCLSAHDLTSLEKMV-------------------- 483 ----------------------------------------------------------MV-TD---DDR--RW-KSG-------------I-Y--G-LPCRNGKLK--------EIDR-FDAAFFGVHPK-QAHTMDPQLRLMLEISYEAIVDGGINP--------LTMRGS--KTGVYI---------------------------------------G-VSGSEA--GEAF-SR---D------------P--E-ELLGYSMTGCQRAMFANRISYFFDFNGP------S--------------------------------------------------------------------TAIDTACSSSLLALENAFHAIRQGHCDAALVGGVNLLLKPNTSVQFMKLGMLSPD-GTCKSFDSSGNGYCRSEAAVVVLLTRKS-A--------------A--KR----VYA-TVLNAGNN--TDGYKEQ-------G---VTFPSGDMQQRLVRSLYQE-A-GVSP-EQVEYIEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEVNGIV-SVFC-Q--E---K----------------------------------------------------------------R----K-PLLIGSTKSN-MGHPEPASGLAALAKVVLSLEHGVWAPNIH-F---H--N--PNSDIPALTDGRVKVVT--EPI-PTSG-----------GIVGINSFG-FGGSNVHVILQPQ--T--LK--V-S------ASSEINPQ--ST-Q-------------------------L------PKLVQVCGRTEDAVKELL-------------------- 484 ---------------------------------------------------------------------------------------------------QRGGFL-----K-N--FD-GFDNGLYGINDF-EAAQMDPQQALLLECTSMALEDAGIPH--------NHLSG--SNTGVFV---------------------------------------G-SMNCDK--RSAD-IG-----------I----T--S-TVDNFSAVGVSPSVMAGRLSYVFNLLGPS------MVLDTACSSALLAIHQACLAIHSGDCDMAVCAGVNTMQSP-EVFCQLSKARMISPTGQCYAFSDKAD--------------------------------------------------------------------GYVRGEGCGVVIVKKLN-D--------------A--LRDGDKIWA-TVC-TGTN--QDGHTVS-------P---MTAPSGEQQKKLLHLVYDK-F-EVDV-SQIDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEVNALG-SFFK-EK---G----S------------------------------------------------------------S-----R-DRYIGSLKTN-IGHTESAAGILSVIKICLMMKYDQIVPSLN-C---E--A--VNPKID-LADLRFIIPMPGNTI-PWSC--P-------DKTAGCNSFG-FSGSNCHAVLKSHR----VR--E-E----------K------R-E----------------KQ-----L-T------SYIVCFSGKSQKSL---K-------------------- 485 ------------------------VVISGISARLP-E-S--D-NMEEFRQHLM-LGEDMV-TE---DDR--RW-QPGL--------------Y--G-LPRRNGKLK--------DLSK-FDASFFGVSPK-QADAMDPQLRLLLETTYECIIDAGVNP--------QSIRGS--KTGVFI---------------------------------------G-SSFSEA--AEAW-TT---D------------L--E-KPIGYSMTGCCRAMFANRLSYFFDWKGP------S--------------------------------------------------------------------YIVDTACSSSLLALDQALNSIRSGHCDAAIVGGCGLLLKPATSLQFLQLGMLSPE-GKCKSFDASGNGYCRSETVGTVFLQKSS-D--------------A--KR----VYA-TVVHSGTN--ADGNKEQ-------G---ITFPSGEIQKELLQQVYTE-A-CVSP-ASVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIA-DVFC-K--G---R----------------------------------------------------------------Q----D-PLLIGSTKSN-MGHPEPASGLAAIAKVLIAMEDKILPPNLH-F---E--E--ANPDIPSLQDGRISVVT--QRK-RWIG-----------GYVGINSFG-FGGANVHAILKSN--E--KE--E------T-I----PHP--DS-K-------------------------S------QRLVTYSGRTEESVQRVL-------------------- 486 ------------------------IAITGIGCCAP-G-A---DNIQDYWRVLR-NGECHV-TDVP-V--D-RW-NAKA--FLD----KDPKAPGKA-YVQKGGFI-----R-D--VD-GFDNGLYGINDY-EAGHMDPQQCQLLQCTTMALQDAGITT--------KDIAG--TNTGVFV---------------------------------------G-CMNNDF--GATF-IG-----------K----T--S-TGESHTATGISNTILASRLAYAFDLRGPC------MVLDTACSVSIVAIHLACQAMRSGDCEMAVCGGVNCLWTP-DMYIVLSKARMVSPTGLCHTFSEKAD--------------------------------------------------------------------GYVRSEGCGVVILKPLK-D--------------A--LRDGDKVWA-TVC-TGNN--QNGHTVS-------P---MTNPSGEQQKKLLTALYDK-F-QVNV-GRIDYIEAHG-----------------------------------------------------------------------T-GTPT------G------DPVEVNALG-SFFK-ER---G----P------------------------------------------------------------P-----Q-TRYIGSVKTN-IGHTESAAGVLGLIK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 487 ------------------------VAISGISGRFP-E-S--E-NMEEFQDHLM-KNEDMV-TE---DNR--RW-DVDE-SSF-----ISGL-H--G-LPPRNGKLK--------ELGN-FDAVFFGVHPK-QADNMDPQLKMLLECSYEAIIDAGQTI--------DSVKGS--RTGVFV---------------------------------------G-VSNSEC--ETAW-SC---D------------P--E-KVVGYSMPGCARNMFANRVSFFFDFRGP------S--------------------------------------------------------------------FSLDTACSSSAVCLDQALQNIRMGNIDAAIVGGSNLVLKAMQSLQFHRMGMLSPD-GSCKSFDASGDGYCRSEAITVVYLQKVK-D--------------C--KR----IYA-TVVHSKSN--SDGYKEQ-------G---ITFPSGIQQQNLVKEVYHE-T-GVNP-LDVSYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNALA-GVFC-K--D---R----------------------------------------------------------------Q----E-PLLIGSVKSN-MGHSECCSGLNAIAKLVIAMENQIIPANLH-F---K--N--PNPDIPGLTDGSFKVVA--KNT-RWKG-----------DFAALNSFG-FGGSNVHCLLKSN--K--KE--F-K------T----AHP--AS-Q-------------------------K------PRLFTYCGHTVEGVQAVL-------------------- 488 ------------------------------------------------------------------------------------------------------------------------------------------------------------SL--------ESMKGT--KTGVYI---------------------------------------G-ALPSDS--GESM-RQ----------------L--D-RINPYSFIGYVPCHLANRLSYFFDLKGP------S--------------------------------------------------------------------FTIDSACSSTMAALENAVMQIRLGHLDSAIVGTCNLCIDPLGTLLATSVGMLADD-GKCKAFDAAASGFVRADGNIAVLITKRS-L--------------A--KR----VYG-TILHMRGN--NDGFTKE-------G---IAVPSGDSQSDLFRVVYEE-M-GIDP-NQVFFAECHG-----------------------------------------------------------------------P-GTVV------------GDGVEVDALA-KHLCSN------R---------------------------------------------------------------K-----Q-PLYVGSVKTN-LGHCEGSAGLASLTKAIIAMHTMRIPPNLH-F---K--N--PNPNIKSLCDGRVAVPT--EPV-TFER-----------GIMSVSSFG-VGGTNYNVCLRCF------------------------------------------------------------------------------------------------------ 489 ------------------------VAISGISGRLP-E-S--N-NLQEFRDHLM-NKEDMV-TA---DDR--RW-TV-------------GL-H--G-CPPRNGKVP--------EITK-FDAGFFGVHPK-QTDCMDPQLRMLLEASYEAIIDAGQSM--------ESVRGS--RTGVYI---------------------------------------G-VSLSDS--SDAW-TM---E------------T--E-GMIGYTMPGCCRAMFANRVSFFFDFKGP------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALMGIRTGLIDSAIVGGSNLCLKPNTSLQFVRMGMTSPD-GACKTFDASANGYCRSEAVMAIFLQKVP-E--------------S--KR----IYA-TVVHTKAN--CDGYKEQ-------G---ITFPSGDLQKRLIREVYDE-I-GINP-ADINYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQEINSIV-DVFC-E--N---R----------------------------------------------------------------T----S-PLLIGSTKSN-MGHPEAASGLTSIAKIIISMEEKILPPNLH-Y---N--N--PNPEIPGLTDGSLQVVD--KCT-KWNG-----------GLVAMNSFG-FGGANVHAIYKSN--D--KE--L-K------E----PHP--AS-E-------------------------K------PRLFTYGGRTEAGVKAVL-------------------- 490 ------------------------VSISGISGRYP-E-S--N-NIQEFQEHLL-NNEDMV-TV---DNR--RW-EP-------------GY-M--G-LPTRNGKLK--------NLGV-FDSTFFGVHGK-QADSMDPQLKMLLEASYEAIVDAGQSM--------ESIKGS--RTGVFI---------------------------------------G-NSQSES--AVIW-FS---D------------P--D-KLVNYSLSGCARNMFANRISYFFDLKGP------S--------------------------------------------------------------------YTVDSACSATAMCVDQALQSIRMGVIDAALVGGANLCLQYTFSMLFLKLGMLAPD-GSCKAFDSSGNGYVRSEAVNVIYLQKSK-D--------------C--KR----IYA-TLVHAKSN--CDGYKVE-------G---VTFPSGAQQNALIREVYEE-S-GVNP-LDVAYIEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNSLA-DVFC-K--G---R----------------------------------------------------------------K----E-PVLIGSVKSN-MGHSECCSGLNAISKVIIAMESQIIPANLH-F---N--E--PNPEIASLNDGRFKVVT--ENT-RWKG-----------GLVGLNSFG-FGGSNVHMLFRSN--Q--KE--F-N------E----PHF--AS-Q-------------------------K------ARLFTYCGHTEDGVRAVL-------------------- 491 ------------------------LVISGISGKFP-A-S---RDVNELWDNLC-NKVDMM-GA---SDG--IH-NRMP--------------LEFM-DVGNYGKIY--------DTEK-FDNEFFRINPE-ASNWMTPESRMCMEMAYEAIVDAGHSI--------ESMAGR--NTGTFY---------------------------------------SHGAIFEA--PHSF-PN---N------------P--D-NISSHSFVGLVTSMLPNRVAHYFDLRGR------S--------------------------------------------------------------------VLVDSACSSSLSAFDLAVEAIRNGTIDSALIGGAGCTFGPQIGMELKKFGVASSN-GRCKVFDSSADGYGRSDAAGTLLLEKKS-E--------------A--RR----CYA-SIVETGCG--HDGKTAS-------V---FGATSTVTQHELIKDVLKR-S-GVDH-REIDFVETHG-----------------------------------------------------------------------T-GTQV------------GDPNEVKALDIDGLL-TK-D---R----------------------------------------------------------------K----H-PLMVGSIKSN-LGHSECLSGLPSLTKAVMIMHHDSIPPNLN-YS-LE--T--TNPKIDSILEGRVVVPT--ENT-PYKG-----------GLVAVNSFG-IGGSIAHILLAPP--D--TK--K-------------KSLSPAG-K-------------------------A------PRLFTYAGRCEEGLTEVL-------------------- 492 ------------------------VAISGVSGRFP-E-S--A-NMEEFQEHLM-NNEDMV-TE---NNR--RW-DV-------------GL-H--G-LPPRNGKLK--------ELGH-FDARFFGVHPK-QADNMDPQLKMLLECSYEAIIDAGQTI--------DSVKGT--RTGVFI---------------------------------------G-VSGSES--EAAW-SC---D------------P--E-TLVGYSMPGCARNMFANRISFFFDFRGP------S--------------------------------------------------------------------FTVDTACSSSALCLNIALQNIRMGNIDAAIVGGSNLTLKAMQSLQFLRMGMLAPD-GSCKSFDASGDGYCRSEAITAIYLQKSK-D--------------C--KR----VYA-TVLHSKTN--SDGYKEQ-------G---ITFPSGTQQQNLIKEVYHE-S-GVDP-LDVSYVEAHG-----------------------------------------------------------------------T-GTKV------------GDPQELNSLA-GVFC-K--G---R----------------------------------------------------------------Q----E-PLLIGSVKSN-MGHSECCSGLNAIAKLVIAMENGVIPANLH-Y---K--N--PNPEIPGLTDGSFKVVS--ENT-DWKG-----------GLAALNSFG-FGGSNVHCLFKSN--T--KE--P-K------T---TPHP--AS-G-------------------------K------PRLFTYCGHTEEGVRAVL-------------------- 493 ------------------------IAIVGVGCRFP-G-A---NNIDEFWQILV-KGENHV-TEIP-S--E-RW-NLEA--YYD----EDADAPGKM-YPRKAGFL-----S-N--FD-EFDYKLFEINEK-EAQRMDPQQKYILECVFMALQDGGFTK--------KSIQR--SKTGVFV---------------------------------------G-VMNDDY--SRLT-SR-----------N----D-----TNHYSVTGGSTSIMSARISYTFDLRGPC------LSLNTACSSSLVAVHLGCQSLKSGECNMAICGGVNSLLTP-SIFIQLSKARMVSRTGQCQAFSANAD--------------------------------------------------------------------GYARGEGCGIVLLKKLS-D--------------A--LRDGDNIWA-TIV-TGTN--QDGRAAS-------P---MTAPSGEQQYQLLKTVYEE-A-GIDA-KQIDYIEAHG-----------------------------------------------------------------------T-GTVA------G------DPVEVNSLG-RFFL-----EK-A--D------------------------------------------------------------------KKIRYIGSVKTN-IGHLESASGIAGIIKVLLMMKNNKIVESLL-TG-----E--QNPRID-FHKFHFEIPT--KLT-NWDK---------ENKVACVNSFA-FGGTNCHAVISTHR----E---I-T----E-----N-KG--ET---NS--KVP-------------------------LLFCFSGQDENAL---Q-------------------- 494 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------g-amnady--rglf-ss-----------r----t--s-vvdnytvtgvsnsiiaarisfifdlrgps------ltldtacssgllavhlgvqalrtgdcdialcggtnflilp-etfvhlskarmvsptgqcfgfsdrad--------------------------------------------------------------------gytrgegcgmvlikrlk-d--------------a--vrdgdhiwa-tle-tgsn--qdghava-------p---isapsgeqqlklleyiykt-t-gida-ncidyievhg-----------------------------------------------------------------------t-gtaa------g------dpievnalg-sffk-tq---g----a------------------------------------------------------------e-----r-qrhigsvktn-vghlesaagtaglikvllmmkhskivpslf-fd-----r--pnpkid-feglklnvpt--kvl-dwlt--p-------kkvacvnsfg-mggtnchavvm-------------------------------------------------------------------------------------------------------- 495 ------------------------VVISGISCRLP-E-S--D-NIEEFRQHLI-NKDDMV-TD---DER--RW-PKGL--------------Y--G-LPPRNGKLK--------DITK-FDAAFFGVHPK-QANSMDPQLRLLLEVTYESIIDAGVNP--------DTIRGS--KTGVFI---------------------------------------G-CSASES--HDAW-SC---D------------P--E-KTVGYSMTGCTRSMFANRLSFFFDFKGP------S--------------------------------------------------------------------FAIDTACSSSLLAMDQALHSIRQGHCDSAIVGGCNLCLKPTTSLQFQKLGMLSKE-GTCKSFDASGDGYCRSEGVVAIYLQKQN-V--------------A--KR----IYS-TIVNSKTN--SDGSKEQ-------G---ITFPSGSIQKQLLNEVYSE-A-CIDP-TSVEYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQELNAIC-DVFC-K--D---R----------------------------------------------------------------S----T-PLLIGSIKSN-MGHPEPASGLAAVTKLIIGMEDKQMPANLH-Y---E--T--PNTDIPGLTDGRLEVVT--ERT-PLNG-----------GLVAVNSFG-FGGSNVHAVLKP--NID--S--D-------------SHA--CD-L-------------------------S------KRLFLYSSRTKQGLEKIL-------------------- 496 ------------------------VVISGVSCRLP-E-S---DNIEEFKQHLI-NKDDMV-TD---DAR--RW-PKGL--------------H--G-LPARMGKLK--------DITK-FDAEFFHIHPK-QANSMDPQLRLLFEVTHESIIDAGVSP--------DSLRGS--RTGVFI---------------------------------------G-CSLSES--HDAW-SS---D------------P--E-KTLGYHLIGCHRTMFANRLSFFFDFKGP------S--------------------------------------------------------------------LSVDTACSSSLTAMDQAFHSIRQGHCDAAIVAGCNLCLRPTTSLQYHKLGMLSKD-GTCKSFDASGDGYCRSEGVVAVFLQKQN-V--------------S--KR----IYC-TILHTRSN--NDGRKER-------G---ITFPSGTAQKHLLQSVYRH-I-SVNP-GAVEYVEAHG-----------------------------------------------------------------------T-GTQA------------GDQQELNTIC-DIFC-K--D---R----------------------------------------------------------------T----G-PLLIGSIKSN-IGHTEPAAGLVAVTKLIICMESNQIAANLH-Y---M--K--PNPEIPGLSNGKLKVVT--EQT-SFNG-----------GLVAVNSFG-FGGSNSHIVLRPH--Q--CS--N-------------I--TSCD-L-------------------------L------KRLFVYTSRTKKGLNRVM-------------------- 497 -------------------------VIAGLSCRLPK--S---DNIDEFWNNLI-NGKDMI-G-------ETRW-PVG---LYD--------------TPPRAGLIN------G--ID-KFDAGFFRFTD-SEAHNMNPLLRHLFEVSYECITDSGIPL--------SVLHSN--TTGTYT---------------------------------------A-CFIPDN--DPL-ET---------------------SRC-ADSKYCTTVSMITGHLMNQFRFTGPS------ATVDTACSSSVSAMEMAVQDLMTGRCQFALVTACNLLLNP-SYLQQMSFLGMLSSEGQSRVFDADAK--------------------------------------------------------------------GYVRAEGIVSILLTRQA-S---------------LCQR----IYCS-VIDVKTS--CNGYNPD-------G---ITFPSKDCQCALMKEIYK-R-SEIKW-DDIAYMELHS-----------------------------------------------------------------------T-GTPV------G------DPIEARSVT-EAIC-SA--R------------------------------------------------------------------E-----K-PLLIGSVKAN-MGHSEATAGLASLVKCILAAQHGIIPPQIN-FK-----T--PNPNIEAIKEGKIVVCK--EPT-ELKD----G-------YIGLNSFG-FGGANGHVVLKPFK----RK--R-K------A---M-G--------KT----------------------F-------CLIPVTARTVQEQKA-I-------------------- 498 ------------------------VAIIGIACRFP-G-A---DDADEFLKNLE-EGKCFI-DEV-PK--R-RW-DSNK--ADV----KDSDESWKD-SSKYAALI-----D-E--YD-KWDNKFFGISDS-EAAWMNPQHCLALEVTHSAIENAGITL--------DQIKG--TRTGVFI---------------------------------------G-AMNDDF--LLGL-P------------S----S-RH-ELNNFVVTGMAPSITSNRISYHFDLRGPS------MTLDTACSSALVAVHLGCQSIRSGEIETAVCGGVNIILTP-LNFIPLSKAKMISPTGKSCAFSKDAD--------------------------------------------------------------------GYVRGEGCGIVILKNYK-KAVK----------------DGDRIWS-IVA-TGCN--QDGHSNT-------P---ITAPSSSQQHALLQDIYTK-F-RVDP-ASIQYIETHG-----------------------------------------------------------------------T-GTPV------G------DPIEVNALA-TFFA-PY--LN-D---------------------------------------------------------------E-----K-LIPIGSVKTN-IGHLESSAGTAGLIKTILMMKSGNFVPYLN-FK-PE--N--ANPKID-FENIPFRVIQ--APE-KWLS--S-D--D-GSRSACVNSFG-FGGTNCHAIIRQLN----NG--D------K-Q---M-AC--RA-N-PS---AYVL-IC-FS--------AK------SLPALI-------------------------------K 499 ------------------------IAIVGVGCKFP-G-A---DNIEEFWKVLY-NGENHV-NEIP-I--D-RW-NVEA--FHS----EDLDSSGKT-YAKHAGLV-----K-N--FT-QWDNNCFGINDI-EAKEIDPQQRYVLECVHMALEDGGITR--------ESIKG--SDTGVFI---------------------------------------G-VMNDDY--KGIG-A-----------DD----F--K-SMSNYTLTGASMSLIANRVSYVYDLSGQS------MCIDTACSSSLVAIDVGILYLKSGRMSMAICGGVNSILSP-DLFIALSQAKMLSPTGQCKAFSENAD--------------------------------------------------------------------GYARGEGCGIVILKKLK-Q--------------A--KTDGNKIWG-VIA-TACN--QDGQNVR-------P---ISAPSQTQQEKLLNSIYER-N-KVNP-HDIQVIEAHG-----------------------------------------------------------------------T-GTPK------G------DPIEANSLG-KVLG-RM--FH-S--ETK---K---------------------------------------------------V--D-----E-PVYIGSVKTN-IGHLESAAGVAGLIKMLLMMKNRIIVTSLH-FM-K------ANPLAN-FDRFNFCVPT--SNL-EWKC--H-P--Y-QRRIGCINSFG-FGGTNAHAIVKEYR----GN--K------E-A---E-C--------ET--------------------E-K------NCLVFHSAMTPDGLY----------------------K 500 ------------------------IAIVGVGCKVP-G-A---DNIEEFWKVLY-NGENHV-KVIP-N--D-RW-NKEA--FSS----EDMNSSGKT-YAKHAGLV-----K-N--FT-QWDNKCFGINDT-EAKEIDPQQRYVLECVHMALEDGGITR--------KSIKG--------------------------------------------------VMNDDY--KGIG-S-----------DD----L--K-SMSNYTLTGASMSLIAARVSYVYDLSGQS------MCIDTACSSSLVAIDVGIKYLKSDSTSMVICGGVNSILSP-DLFVALSQAKMLSPTGQCRAFSENAD--------------------------------------------------------------------GYARGEGCGIVILKKLK-Q--------------A--KEDGNKIWG-VIA-TACN--QDGQNVK-------P---ISAPSQTQQEKLLKSIYAH-N-KVNP-HDIQVIEAHG-----------------------------------------------------------------------T-GTAK------G------DPIEANSLG-KILG-RS--SF-P--ETN---T---------------------------------------------------V--D-----R-PVYIGSVKTN-IGHLESAAGIAGLVKMLLMMKNRIIVPSLH-LI-K------ANPMID-FDRFNFCVPT--SNL-EWNC--H-P--P-KRRMGCINSFG-FGGTNAHAIVKEYC----GN--K------E-V---K-Q--------EM--------------------E-K------TCLLFHSAMTPD-------------------------- 501 ------------------------IAIIGIGCKFP-G-A---DNQEEFWQLLV-NGENHV-IDIP-S--E-RW-NNDA--FYN----SDPNAVGKT-YVPRAGFL-----K-S--HD-EFDNKLFGINDL-EAERMDPQQRYVLECVHMAMEDGGITR--------NMISG--SDTGVFI---------------------------------------G-FMNDDY--KASA-GD-----------D----L--T-TMTNYTLTGTSPSIISARVSYVYNLLGPS------MSIDSACSSALVAIDVAAQSLKMGRSTMAICGGVNSILSP-ELFIPLSRARMASPTGQCHAFSSNAD--------------------------------------------------------------------GYARGEGCGIVILKKLG-D--------------A--KKDSNKIWA-TIA-TDCN--QDGHTAT-------P---ITAPSACQQEKLLLRVYLS-N-NVNP-NDVKVIEAHG-----------------------------------------------------------------------T-GTPV------R------DPIEVNTLG-RFFG-KK--T-ND---QS---L---------------------------------------------------E--K-----H-VVYIASVKTN-IGHLESAAGVAGLIKVLLMMKNETIVPSLN-F---E--K--PNEKID-FEKYHFIVPT--HTI-QWKP--D-A--N-NQRIACGNCFG-FGGTNSHVIVKQFQ----QE--K------R-C---Q-E------------------KHLDML----------------HLVFLSAVDLDGL-----------------------K 502 ------------------------VVISGISCPTS-E-S--D-NIEEFRQHLI-NKDDMV-TD---DER--RW-PKGL--------------Y--G-LPPRNGKLK--------DITK-FDAAFFGVHPK-QANSMDPQLRLLLEVTYESIIDAGVNP--------DTIRGS--KTGVFI---------------------------------------G-CSASEA--HDAW-SC---D------------P--E-KTVGYS---------------------P------S--------------------------------------------------------------------FAIDTACSSSLLAMDQALHSIRQGHCDSAIVGGCNLCLKPTTSLQFQKLGMLSPE-GTCKSFDASGDGYCRSEGVVAIYLQKQN-I--------------A--KR----IYS-TIVNSKTN--SDGSKEQ-------G---ITFPSGYVQKQLLNDVYSE-A-CIDP-ALVEYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQELNAIC-DVFC-K--D---R----------------------------------------------------------------S----T-PLLIGSIKSN-MGHPEPASGLAAVTKLIIGMEDKQMPANLH-Y---E--S--PNTDIPGLTDGRLEVVT--ERT-PLNG-----------GLVAVNSFG-FGGSNVHAVLKP--NVD--R--D-------------TNA--CD-L-------------------------S------KRLFLYSSRTKQGLEKIL-------------------- 503 ------------------------VVISGISCRLP-E-S--E-NMEEFKKHLM-RGDNMI-TE----NR--RW-EPAA--------------H--G-LPSKSGTLV--------DISK-FDAAFFGVPPK-LADSMDPQLRIMLELTHEALVDSGVSP--------ATIRGS--NTAVYI---------------------------------------G-CGMSEA--WEAL-ST---D------------N--S-NVTGYSPLGCTTSMFANRISFAFDLRGP------S--------------------------------------------------------------------YGLRNGCGSGLLALDRAISSIRLGDCDTAIVAGCNLCMKPATSVQLAEMNLLSMD-GHCRCFDERGEGFGRSEGVVVMCLQKKA-K--------------A--KR----VYC-TVIHSKSA--TFTTENN-------N---FNFPNFEEERQFLHETYRE-A-RLDA-SHISYMETGS-----------------------------------------------------------------------S-CTKM------------SDTIELNAIS-DVIC-K--N---K----------------------------------------------------------------S----K-PLLIGSVKSN-IGHTEATSGLAAVSKIIIAMEDGVIPPNLH-F---N--M--PN-----IQNEQIKVVS--ERT-RLNG-----------EYCAVNSFG-LGGVNVHTILKSY----DKD--K--------K----YHF--AN-E-------------------------K------KRLCIYSARTKQGL---E-------------------- 504 ------------------------VVISGISCRLP-E-S--D-NIEEFRQHLI-NKDDMV-TD---DER--RW-PKGL--------------Y--G-LPPRNGKLK--------DITK-FDAAFFGVHPK-QANSMDPQLRLLLEVTYESIIDAGVNP--------DTIRGS--KTGVFI---------------------------------------G-CSASEA--HDAW-SC---D------------P--E-KTVGYS---------------------P------S--------------------------------------------------------------------FAIDTACSSSLLAMDQALHSIRQGHCDSAIVGGCNLCLKPTTSLQFQKLGMLSPE-GTCKSFDASGDGYCRSEGVVAIYLQKQN-I--------------A--KR----IYS-TIVNSKTN--SDGSKEQ-------G---ITFPSGYVQKQLLNDVYSE-A-CIDP-ALVEYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQELNAIC-DVFC-K--D---R----------------------------------------------------------------S----T-PLLIGSIKSN-MGHPEPASGLAAVTKLIIGMEDKQMPANLH-Y---E--S--PNTDIPGLTDGRLEVVT--ERT-PLNG-----------GLVAVNSFG-FGGSNVHAVLKP--NVD--R--D-------------TNA--CD-L-------------------------S------KRLFLYSSRTKQGLEKIL-------------------- 505 ------------------------------------------------------------------------------------------------------------------------------IHQK-QANSMDPQLRLLFEVTYESIIDA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDGYCRSEGVVAVFLQKQN-V--------------S--RR----IYC-TILHARSN--NDGRKEK-------G---ITFPSGNAQKELLQGVYRD-I-SVDP-GSVEYVEAHG-----------------------------------------------------------------------T-GTQA------------GDPQELNTIC-DIFC-K--D---R----------------------------------------------------------------T----R-SLLIGSVKSN-IGHTEPAA---------------------------------------GLSNGKLKVVT--EHT-SFNG-----------GLIAVSSFG-FRGSNSHIVLRPH--Q--GS--R-------------I--TSGD-L-------------------------S------KRLFVYTSRTKKGLEKVL-------------------- 506 ------------------------VAIVGIACRFP-G-A---DDIDEYWENLK-EGKCFI-DEV-PK--T-RW-NTND--TDV----KDVDDSWKD-RSKFAALI-----K-E--HD-KWDNKLFGVSNS-EAGWMNPQHCLALEVTYSALENAGYTK--------HAIKG--TKTGVYI---------------------------------------G-AMNDDF--LIGL-P------------N----S-RH-ELNNFVVTGMAPSITSNRISYYFDLRGPS------MTLDTACSSALVAVHLGCQSIRSGESEIAICGGVNSILST-LPFMALSKAKMISPTGKSRAFSKDAN--------------------------------------------------------------------GYVRGEGCGIVILKNYK-QTVSIDLEFDSFFMQA--QLDGDHIWG-LIA-TGCN--QDGHTNT-------P---ITAPSSKQQQSLLTDMYST-F-KVDP-ATIQYIEAH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKTN-IGHLESSAGTAGLIKTLLMMKQRQFVPSLH-FN-KD--N--ANPAIP-FNDIPLQVSI--AVT-DWKA--Y-P--D-GSRIACVNSFG-FGGTNCHAIVKHMQ----N------------S---R-SS--HT-S-QN---EYVL-IS-FS--------AN------SLEALM-------------------------------K 507 ------------------------VAVVGIGCRFP-G-A---NNIDEFWNLLE-KGENHI-KEV-PK--H-RW-NVDE--IDY----TGTDDSWKN-SAKYAGLI-----D-D--FD-KWDNKFFGIGDT-EAGWINPQTALTLEVTHSALENGGLTL--------QNLKG--SNTGVYI---------------------------------------G-VTNNDM--MCGA-S------------R----C-RD-ESNISMLTGIASSLTANRISHFYDLRGPS------MVVDTACSSSLTAVHMACQAIRTGECSMAICGGVNSILSP-GIFIVLGQAKMISHSGKSHPFADDAE--------------------------------------------------------------------GYAK-----------------R----------------DGDNIWG-TIV-CGCN--QNGKTSS-------P---ITAPSSTQQRVLLDDVYRR-F-KVDP-SIIQYVEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEMTALS-EFYG-QY--FS-K---------------------------------------------------------------T-----Q-TVSMGSVKSN-IGHLESAAGIAGLIKTLLMMRHGKIVPSLH-YK-EG--K--GNSSID-FENNALKVAT--STI-PWPV--R-P--D-GSRYGSINSFG-FGGSNAHAIV--------------------------------------------------------------------------------------------------------- 508 ------------------------VAIIGVGCKFP-G-A---NSLEEFWRVLE-NGENHV-IEIP-E--T-RW-FHEA--FYD----SDFNTPAKT-HARKAGLL-----K-D--HL-AFDNKLFNIKDV-EADIMDPQQRYVLECCHRALEDAGITR--------DQIKG--SNTSVYM---------------------------------------G-AMNQDY--RSEF-NA-----------P----S--M-VPDNYAVTGVSSSIIANRVSFVYDLRGSS------VTLDTACSSSLVAIDLGYMALKAGVCDMAICGGVSSILCP-DLFIHLSKARMVSAKGQCFAFSDQVD--------------------------------------------------------------------GYTRGEGCGVVILKRYQ-D--------------A--IKDKNKIWA-TID-SFSN--QDGGTVT-------P---MSKPSGEQQVRLLEEIYSR-N-RIDP-KRLAYIEAHG-----------------------------------------------------------------------T-GTVV------G------DFTEVNALG-KFFK-IK--Q-----A------------------------------------------------------------E-----QY-RYLGSVKTN-IGHLESAAGSAGLIKVLLMMKHSKIVPSLH-FD-RP------NPNID-FNGFNLRVPT--KVI-AWQA--V-------TKLASVSSYG-FGGTNCHAIIESHG----QP--P-S------I---S-S----D-V-K-----------------------A------ESIVCFSAMNLESL---K-------------------- 509 ------------------------VAIIGLGCKVP-G-A---DNLEELWRLLK-NGENHV-IEIP-T--T-RW-HHEA--VYD----EDFNTPAKT-HARKAGLL-----K-D--HL-AFDNKLFNIKDV-EADIMDPQQRYVLECCHRALEDAGITR--------DQIKG--SNTSVFI---------------------------------------G-AMNTDY--RSEF-NS-----------T----S--F-VPDNYAVTGVAS----------------------------------------------RACDMVICGGTNSILTP-DVFIHLSKARMVSPKGQCFAFSDQVD--------------------------------------------------------------------GYTRGEGCGVVILKRLH-D--------------A--LEHKNKIWA-TIE-TGCN--QDGGTVT-------P---MSKPSEEQQTKLLQEVWSK-S-QADP-SLLTYIEAHG-----------------------------------------------------------------------T-GTPV------G------DVVEVKSLG-TFLK-RN--Q-----V------------------------------------------------------------E-----RS-RYIGSVKTN-IGHLESAAGVAGLIKVLLMMKHSKIVPSLH-FQ-RP------NPAID-FSGYQLKVPT--VLT-DWPD--V-------HKVASVSSFG-FGGTNCHAIIESPE----QL--G-S------T---E-H----D-M-N-RPAM-LISHV-QQRVIKHGIK-Q------GSIVCFSAMNMESL---K-------------------- 510 ------------------------------FKIYR-S-S---NKLGNKQRNRE-GTG----SS---GDG--VY-QKS-------------Y-G--D-IMDRAKSDR--------SVLREANLERSLIKTI-RQRQLQVLGHICRDKSLEYLVNTGESL--------SSIKGT--RTGVYV---------------------------------------A-IASSEA--ESAW-AI---K------------------KDPYIVMGCPHTMSPNRVSYFFDIHGP------SVAYDTACSSSLVSLEAAMSHMRNGVIDSAIVAGLNICFRA-LTSKIYQSMGMLGQE-ACKTFDASGPSVAYDTACSSSLVSLEAAMSHMRNGVIDSAIVAGLNICFRALTSKIYQSMGMLGQD--ACKTFDASGDGFVRGEIISAIFLKKAV-D--------------S--KR----IYC-SIVDCLTN--NDGFTPQ-------G---LTYPNGEAQEQLMREVYAH-C-KVSP-QEVTYFECHG-----------------------------------------------------------------------T-GTPA------------GDPQESNAIS-RVMCPK--E---R----------------------------------------------------------------N----G-PLLVGSVKSN-MGHGETGSGHASITKVVLAMHEGVIPPNLH-F---R--T--PNPKIEGLLDGRMAVVT--EPT-PWL-----------GGYIAINSFG-MGGSNAHILFKSP--D--IP--R-R------E----LHP--SS-N-------------------------K------PRLFTYCARTEQGLRAIL-------------------- 511 -------------------------------------------------------------------------------------------------------LKN--------DIAE-FDAEFFGIHSR-SANTMDPMIRNLLEVTYEALVDAGESL--------ASMKGS--RTGVYI---------------------------------------G-VTSAEF--EMAL-GR---S------------C--T-ENEAYLVQGAPHSMFSNWVNYFFDLRGP--------------------------------------------------------------------------SCAYDTACSSSLVCLEAAERHLRQGVIDCAIVGGCSFVVRPQTSAIMNMMNFLSQS--ACKSFDASGDGFVRSEVVSAIFLKKAG-D--------------A--KR----IYS-TLVATMTN--NDGFQPN-------G---IMYPNTVAQEELICDFYTN-I-KVNP-NEIKYFECHG-----------------------------------------------------------------------T-GTQA------------GDPQETKAIC-NGLC-T--R---R----------------------------------------------------------------K----D-TLLIGSVKSN-MGHGETASGMAGLTKVMIINHARKIPPNLH-F---N--T--PNPNIPGLFDGRLKVVT--ETT-PFD-----------GGLISINSFG-MGGTNAHAVFKSF--D--KK--A--------P----VHP--AS-D-------------------------K------PRLFTYSARTEEGL------------------------ 512 ------------------------VAITGISGRLP-E-S--N-NIREFRDHLM-NKEDMV-TA---DDR--RW-TV-------------GL-H--G-CPPKNGKVP--------EINK-FDAGFFGVHPK-QTNCMDPQLRMLLEASYEAIIDAG---------------------------------------------------------------------------------------------------------------------------------P------S--------------------------------------------------------------------YAVDTACSSSMMCLDQALMGIRTGLIDSALVGGSNLCLKPNTSLQFVAMGMAAPD-GTCKTFDASANGYCRSEAIMAIFLQKVP-E--------------S--RR----IYA-TVVHTKSN--CDGYKEQ-------G---ITYPSGELQKRLINELYAE-I-GIDP-VEISYMEAHG-----------------------------------------------------------------------T-GTKV------------GDPQETNAIV-DVFC-K--N---R----------------------------------------------------------------T----S-PLLIGSTKSN-MGHPEAPSGLTSIAKIIISMEEKVLPPNLH-Y---N--N--PNPEIPGLTDGSLKVVD--KCT-KWDG-----------GLVAMNSFG-FGGANVHAVFKSN--E--KE--L-K---------------------------------------------------------------------E-------------------- 513 ------------------------IAIVGIGCRTP-G-A---DNIREFWKLLS-NGECHV-GGVP-H--D-RW-NSKA--YYD----PDPMAPGKA-------------------PE-GFDSALYGINDF-EASHVSPQQKFLLDCTNMALEDAGITK--------TQISG--TNTGVFV---------------------------------------G-SMNNDH--LATF-LG-----------H----N--N-KVATHTVTGTSTTILSARLSYVFNLLGPS------MVLDTACSSSLVAIHLGCQAILTGDCNMAICGGVNAMQIP-DVYVQLSKARMISPTGLCQTFSDKAD--------------------------------------------------------------------GYIRGEGCGVVILKRLE-D---------------------------------------------------------------QKKLLHSVYGK-F-GVDV-ASLDYIEAHG-----------------------------------------------------------------------T-GTPA------G------DPVEANALG-EFFN-QA---G----E------------------------------------------------------------P-----R-DRYMGSVKTN-IGHTESAAGVLANTKKSLTGS----LEDLY-T---D--K--EAPLLN-VHDVSYTSTV--RRD-HYY----------------------------------------------------------------------------------------------------------------------------------------- 514 --------------------------------------------MEEFRQHLM-LGEDII-TE---DDR--RW-PPGL--------------M--G-LPAGMGKLK--------DISK-FDASFFGVSPK-QADLMDPQVRMLMETTYECIVDAGVNP--------QSLRGS--KTGVFI---------------------------------------G-ASFSEA--AEAF-AA---N------------A--E-KNIGYALTGCCRAMFANRLSFFFDLRGP------S--------------------------------------------------------------------FTVDTACSSSLLAMDQALHSIRMGHCDAAIVGGSGLLLKPASSMQFMQLGMLAPD-GRCKSFDASGNGYVRSEAVSTVFLQKAA-D--------------A--KR----IYA-TVVHSGTN--TDGNKER-------G---VTFPSGEVQKQLLQRVYSE-A-CISP-ATVAYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEANAIT-EVFC-K--G---R----------------------------------------------------------------Q----G-PLLIGSTKSN-MGHAEPASGLASVAKVLIAMEDGLLPPNLH-Y---S--H--PNPDIPGLMDGRLQVVA--QRK-RWDG-----------GIVGINSFG-FGGANVHTILKSS--S--QQ--R------T-S----PHP--DA-E-------------------------------------------------S-------------------- 515 ------------------------IAIVGVGCVTP-G-A---GNLDEFWRVLV-NGENHV-IDIP-P--E-RW-NVDA--YYS----PDTTSPGKS-YVRRAGLI-----K-A--PD-EWDNRLFNINDF-EADQTDPQQRLVLDCTHMALENAGITR--------AQLQG--SNTGVYV---------------------------------------G-AMNSDY--RGLF-TA-----------A----S--T-NVGNYTATGISNSIIAARVSYVFDLRGPS------MTIDTACSSALVSVHLGAQAIKAGDCDMALCGGTNYLTLP-DVFVHLSKAHMLSPTGQCHAFSDAAD--------------------------------------------------------------------GYTRGEGCGMIVLKRLR-D--------------A--ERDGDNIWA-TVV-TGSN--QDGRTVS-------P---MSAPSMTQQIKLMEHIYAN-P-QIEI-DRVDYVEAHG-----------------------------------------------------------------------T-GTPA------G------DPIEANAVG-NFFK-DN---S-T--V------------------------------------------------------------S-----R-TRYIGTVKTN-MGHLESAAGAAGIIKVLLMMRHSQIVPSLH-FA-NN--N--PNPRIN-FEELQLQVPT--EVI-DWPT--E-------NKIACASSFG-FGGTNSHAVLIEYC----KP--K-N------E--------------------------------------------------------------S-------------------- 516 ------------------------IAIVGIGCRTP-G-A---DNIKQFWQLLV-NGECHL-TEVP-A--N-RW-NASA--FLD----PDPAAPCKA-FVQRGGFM-----E-D--PY-GFDNSLYGINDF-EAASMDPQQCLLLECTTMALLDAGITR--------AQLSG--SNTGVFI---------------------------------------G-SMNSDS--QEVL-PA-----------H----S--S-TIDNYTASSISTSILSGRLSYVFNLLGPC------MVIDTACSSSLVAIHQARVAILNGDCDMAICGGVNSMTNP-DMFIQLTKARMLSPTGVCRAFSDKAD--------------------------------------------------------------------GYTRGEGCGVIILKRLK-D--------------A--VRDGDKIWA-TLY-TGTN--QDGHTVS-------P---MTAPSGGQQKKLLQSVYHR-F-GINV-DKVDYVEAHG-----------------------------------------------------------------------T-GTAA------G------DPVEVNALG-EFFS-ET---S----K------------------------------------------------------------P-----R-DRYIGSVKTN-IGHTESAAGILGLIKVVLMIDNEVIVPSLH-C---D--T--VNPKID-LAKLKFSIPK--EPI-QWSR--P-------DKIAACNSFG-FGGSNCHAVVMASK----QS--P-V----------D------E-N----------------RR-----R-K------SCIVCFSASTRKS----L-------------------- 517 ------------------------IVVVGVGCRFP-G-A---DNLDEFWRVLQ-NGENHV-IEVP-P--D-RW-NADH--YYD----PDKNAPGKM-YVRQAGFI-----P-G--FE-EWDNGYFGISDE-EAITMEPQQRIVLQCVDMAAQDGGFTR--------LDLQK--GTTGVYI---------------------------------------G-SMTHDY--NIQG-TD-----------DV------L-ALGTYSVTGSHSSIISARVSYVYNLTGPA------LTIDTACSSSLEAIHLGSQALLTGDCDTAICGGVNYLLEP-NLFVALSKARMLSPSGQCKAFTREAD--------------------------------------------------------------------GYVRGEGCGIVILKRLQ-D--------------A--QRDGNKIWG-MVM-SGTN--QDGQHAQ-------P---ITKPAQDQQQKLIKQIITK-F-HIDK-SKIQVIEAHG-----------------------------------------------------------------------T-GTPV------G------DPVECNALG-TVLG-SD--D------H-------------------------------------------------------------------RKFIGSVKTN-IGHLEAAAGVAGLIKVLLMMKHRIVVPSLW-YR-PD--N--ENPKLR-LSEHGFVVPT--KCE-EWIP--E-D--N-YERLACVNSFG-FGGTNVHVVVREII----SD--A------N-S---I-KT------------------F-VS-------I-L------PPIVAITARDHNTV-----------------------R 518 ------------------------IAIVGVGFKGP-G-A---ENLEQLWDVLK-EGKNCV-NEIP-N--D-RW-NVDA--FHD----PDSESPGKY-CTKKAGLM-----S-N--PF-EFDYSFFNVNSM-ESDQTDPQQKLVLECTYRAMEHAGVTR--------ELLKG--TNTGVYI---------------------------------------G-AMNCDY--RAMF-PV-----------R----S--S-GVSNYTVTGISNSIIAARVSYTFDLRGPC------MVLDTGCSSALIAIHTASQAIRMGDCSMAICGGVNIIISP-DIFVHLTNAKMLSPTGQCHAFSELAD--------------------------------------------------------------------GYARGEGCGIVILKKLS-D--------------A--QRDNDRILA-VIQ-TGTN--QDGHEVT-------P---ISAPSKVQQTQLLEDMYRD-F-NLEQLDEVEYIEAHG-----------------------------------------------------------------------T-GTQA------G------DLAEANALG-EFFT-KR---G----S------------------------------------------------------------C-----K-KRIIGSIKTN-IGHLESAAGVAGLIKVLLMMEHNKIVPSLF-SD-----R--LNHKID-FDKMNLIVSS--ELT-DWMT--D-------KKTVSINSFG-FGGSNCHAIVQTYK----PP--A-A------S---K-KA---------VR----------QCE-----K-K------MCIVCFSGKNLHAL---Q-------------------- 519 ------------------------IAIIGVGFKGP-G-A---ENLEELWGVLK-CGENHV-GEIP-K--E-RW-NVDA--FYD----PDSDSHGKY-CTKMAGLL-----K-K--PF-EFDNAFFNINHI-ESDQMDPQQKLVLECSYRAMEHAGITR--------DMLEG--SRTGVYI---------------------------------------G-AMNCDY--RGMF-PV-----------R----S--F-GVSNYTVTGISNSIIAARVSYTFDLRGPC------MVLDTGCSSALIAIHTASQAIELGECDTAFCGGVNFIATP-DIFVHLSKAEMMSPTGQCHAFSELAD--------------------------------------------------------------------GYARGEGCGIVILKKLS-D--------------A--QRDNDRILA-VIQ-TGTN--QDGREVT-------P---ISAPSKSQQTQLLEDMYRD-F-SLEQLDEVEYIEAHG-----------------------------------------------------------------------T-GTQA------G------DLAEANALG-EFFT-KR---G----S------------------------------------------------------------C-----K-KRIIGSVKTN-IGHLESAAGVAGLIKVLLMMEHNKIVPSLF-SD-----R--LNHKID-FDKLKLVVSS--RLL-NWTS--S-------KKVVSVNSFG-FGGSNCHAIVRSHP----PP--A-A------S---K-DT---------KK----------QYK-----D-K------TCIVCFSGKNFKSL---Q-------------------- 520 ------------------------VAIIGVGFKGP-G-A---DNLQQLWDVLE-RGENHV-IDLP-K--D-RW-NVEA--YYD----PDPQATGKY-YVTKAGLL-----S-N--PF-DFDNQFFDINEI-ESDQMDPQQKLVLECSYRAMEHAGITR--------NMVKC--SKTGVYI---------------------------------------G-AMNCDY--RGLH-PV-----------G----Y--S-YISSYTVTGISNSIIAARVSYAFDLRGPC------MVMDTGCSSALIAIHTACHALRQGDCSMAICGGTNFIASP-DIFVHLSKAQMVSPTGQCHAFSDLAD--------------------------------------------------------------------GYTRGEGCGIVILKKLC-D--------------A--QRDNDRILG-IIQ-TGTN--QDGREVT-------P---ISAPSRVQQTQLLEDMYRD-F-SLEQLDEVEYIEAHG-----------------------------------------------------------------------T-GTQA------G------DVAEANALG-EYFK-RR---G----S------------------------------------------------------------S-----K-RRLIGSIKTN-IGHLESAAGVAGLIKVLLMMEQDKFVPSLF-SA-----P--ANKNID-FDKLQLVVAS--KVE-GWVT--E-------NKVACVNSFG-FGGSNCHAIIRSHH----HI--A-D------D---D-HP---------VK----------NSE-----K-K------SCVVCFSAKNRFS----L-------------------- 521 ------------------------IAIVGIGCKVP-G-A---DNVEQFWKLLE-NGENHV-IDIP-K--D-RW-NNDA--FYD----PDPHAIGKS-YVRRAGLL-----K-D--PL-AFDNKLFNINDF-EADQMDPQQRYILECTFRAMEDAGITR--------DNLAG--SNTGVYVGAMNGDYAELFTYKSAIVGNYTASFILTNNMISGRVFFSG-AMNGDY--RGLF-TA-----------K----S--P-IVGNYTVTGISNSIIAARVSFVFDLRGPS------MTLDTACSSALLAIHIGAQALRAGDCDIALCGGTNFLMSP-DVFVHLSKAHMVSPTGQCFAFSDSAD--------------------------------------------------------------------GYTRGEGCGMVVLKRLK-D--------------A--LRDGDRVWA-TIE-TGSN--QDGHTVT-------P---ISAPSGDQQIKLLTQVYSN-S-GIDL-NRIDYIEAHG-----------------------------------------------------------------------T-GTAA------G------DPVEANALG-KFFQ-EC---G----A------------------------------------------------------------V-----R-HRYIGSVKTN-LGHLESAAGTAGLIKVLLMMKYSKIVPSLF-FD-----R--PNPKIN-FPDMNLSVPT--QVT-NWTA--Q-------NKVACVNSFG-FGGTNCHAVVMEYE----DH----M----S-R---Q-NS---------MV----------EQK-----N-I------PCVVCFSGKHEKSL---K-------------------- 522 ------------------------IVIVGVGCKFP-G-A---DNLDEFWRVLS-EGENHV-IEIP-P--E-RW-NLDA--FYH----EDANEPGKT-YVRHAGLI-----K-R--FD-EWDNKLFGVSEV-EAAQMDPQQRFVLDCVHMAMEDGGITK--------KDLNG--SNTGVYI---------------------------------------G-MMNDDY--KGGT-GT-----------D----L--K-TMNNYSLTGTSPSIASARVSYTYNLLGPS------ITLDTACSSALVAIHIGSQALKTGECNAVICGGVNSILYP-DIFVPLSKARMVSPTGQCQTFSDKAD--------------------------------------------------------------------GYARGEGCGIVILKTKK-Q--------------A--LLDGNKIWA-SIA-TACN--QDGRTMT-------P---ITAPSGLQQRNLLHKLYAD-K-GVNP-EDISYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEANTLG-KFFA-EK--Q--Q--GG----H---------------------------------------------------Y--R-----Q-NVFLGSVKTN-IGHLESAAGVAGLIKVLLMMDHGNIVPSLH-FK-N------PNPNIE-FEKYWLVVPH--NMT-SWPC--T-G--I--GRVACVNSFG-FGGTNSHAIIKQHH----YT--A------V-K---E-L--------KS------K-------------K-E------NHIVTISGSDITSL-----------------------K 523 ------------------------FAIVGVGCKFP-G-A---ENLDEFWRVLL-NGENHV-IQIP-P--E-RW-NVDA--FYN----EDPMEPGKT-NVRRAGFI-----R-K--YD-MWDNKLFGVSQV-ETARIDPQQRFVLDCVHMAMEDGGITR--------EDLNE--TDTGVYI---------------------------------------G-AMNDDY--RESA-ND-----------E----L--T-AMTNYTLTGSSLSIIAARVSYIYNLLGPS------MCVDTACSSSLVAIHLAIQAIKSGDCKAAICGGVNSILYP-HIFIPLSKARMVSATGQCQAFSDTAD--------------------------------------------------------------------GYARGEGCGMVIIKSLK-Q--------------A--KLDGNKIWS-VMV-TGCN--QDGRTAT-------P---ITAPSGRQQSALLERVYHD-Y-KVDP-RVIQYVEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEANSLG-AFFS-KG--K--S--IP----E---------------------------------------------------G--E-----A-DVRIGSVKTN-IGHLESAAGIAGLIKVMLMMQHGKVVPSLH-FR-N------SNPKIN-FGNFNFEVAT--GIT-DWNP--L-P--D-GTRMSCVNSFG-FGGTNSHAIIKQLP----NT--E------K-K---H-H--------NS------C-E-D-------EKS-I------DHFVTLSAVDISSI-----------------------K 524 ------------------------IVISGISCRLP-G-A--D-NMAEFRESLW-QGENNI-SE----NK--RW-TKDL------------P-D--G-TPNKMGILG--------DLGK-FDAGFFGVNPK-VADVMDPQLRMLLEITHEAIVDAGVEP--------HQLKGS--DTGVYV---------------------------------------A-CGLSEN--MEAF-ST---N------------Q--D-YIYAYNPIGNAPTMFANRISFAFDFKGA------S--------------------------------------------------------------------YALRNGHASGLVALDRGLMALRTGQCQAAVVAGCNLCLKVTTSTQLHRNGLLSSH-DVCNCFDEKADGLVRSEGVVAMFLQKKS-S--------------A--KR----IYS-TVLHTKVA--SYRSLS--------P---MLPPSVEEQTEFLKKVYQE-A-GVPP-EHVAYIETSG-----------------------------------------------------------------------C-SVAK------------GEAQEMKALA-RVFS-S--H---R----------------------------------------------------------------S----T-PLLIGSVVSN-IGHMETVSDLVGLAKLILTMEEDIIPPNLH-L---H--T--ANRDLATTLNGQVQVVE--EKT-RLPG---------NSGIVALNSYG-LGNLCAHAVFAAH--D-HQK--S--------K----CHP--AE-K-------------------------L------SRLFTYSARTKEGL---E-------------------- 525 ------------------------VAIVGIGCKVP-G-A---ENIREFWNVLL-KGENHI-VEIP-P--S-RW-NADA--SYD----PDPMAPGKT-YVKRAGLV-----K-G--WD-EFDNKLYGINDF-EAPQMDPQQRFVLDCTFMALQDAGLTR--------AQIAG--SNTGVFV---------------------------------------G-VMNADF--RGLF-TA-----------Q----S--S-NIGNYTVTGISNSIIAARLSYVFDLRGPS------LVLDTACSSSLIAIHLGCQAILTGDCDMAICGGVNYLTLP-DIFVHLSKARMISPTGQCHSFSDKAD--------------------------------------------------------------------GYTRGEGCGIVILKRLR-D--------------A--ERDGDNIWA-TIC-TGSN--QDGHAVS-------P---ITAPSGLQQRRLMEHVYHK-T-GLDL-SAVDYIEAHG-----------------------------------------------------------------------T-GTGA------G------DPVEVNSVG-EYFR-H----T----S------------------------------------------------------------P-----R-HRYIGSVKTN-IGHLESAAGVVSIIKVLLMMKHGKIVPSLH-FQ-----Q--PNPKIR-FQELQLTVPT--SPV-DWTN--P-------RKVACCNSFG-FGGSNSHAVVSFYR----KS--Q-K------E---A-RN---------VDTE--------THL-----G-R------PCIVCFSAVTTKS----L-------------------- 526 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKGT--RTGVYI---------------------------------------G-VSNNEV--DTAY-MK---N------------W--T-DDDAYMVQGCHHSMYPNWISFFFDFSGP--------------------------------------------------------------------------STAYNTACSTSLVCLDAAERHLRMGVIDNAIVGGSNFIYRPATTKLFMGMNFLGSS--TCKAFDESGDGFVRGEVASAILLKKAD-T--------------A--KR----VYC-TLVGSMLN--NDGNQTN----------------DLVTEKLTREYFPP-W-YP----QVKYFECHG-----------------------------------------------------------------------T-GTQA------------GDPNETRAIC-NAVC-K--G---K----------------------------------------------------------------K----D-PLLIGSIKSN-LGHGETASGINGISKVIITMHSRQIPPNLH-F---K--N--PNPKIPGLFDGRLKVVT--ETT-PFD-----------GGLIAINSFG-MGGTNAHAIFRSF--D--KR--A--------E----PHP--AS-D-------------------------K------PRLFTYCARTEEGLQRIF-------------------- 527 ------------------------LVIAGLSGRYP-E-S---DSVSEFRDNLL-NKVNMV-TV---DDR--RW-DSG-------------Y-W--D-TPAAMAKLK--------SLKK-FDAEFFGVHSK-SAETLDPQLRILLEVAYEAVVDAGESL--------ESMKGT--RTGVYV---------------------------------------G-VTGSEA--EHAW-MG---------------------KTNQYVLSGCPHTMFPNRLSFFFDLRGP--------------------------------------------------------------------------SCAYDTACSTSIVIMEAALMHLRAGVIDQAIVGSVNLIMRPQTTKSFVSMNMLGGG--ACRAFDAAGDGFVRAETISACLLKKAE-D--------------A--KR----IFC-TVEACLSN--NDGWSND-------G---LLFPNTYAQEELMRDFYSN-Y-KIDP-REIKYFECHG-----------------------------------------------------------------------T-GTPA------------GDPNEMRAIC-SVMC-A--D---R----------------------------------------------------------------K----E-PLLIGSTKTN-MGHGEVASGFSSMTKVLVAMHTRLIPPNLH-F---Q--T--PNPKIPGLFDGRLKVVT--ETT-PWD-----------GGMVALNSFG-MGGTNAHIVLRSY--D--EK--K-A------E----PHP--AS-G-------------------------K------ARLFTYSARTEDGLKK---------------------- 528 ------------------------VVISGISCRLP-E-S--D-NIEEFRQHLI-NKDDMV-TD---DER--RW-PKGL--------------Y--G-LPPRNGKLK--------DITK-FDAAFFGVHPK-QANSMDPQLRLLLEVTYESIIDAGVNP--------DTIRGS--KTGVFI---------------------------------------G-CSASEA--HDAW-SC---D------------P--E-KTVGYSMTGCTRSMFANRLSFFFDFKGP------S--------------------------------------------------------------------FAIDTACSSSLLAMDQALHSIRQGHCDSAIVGGCNLCLKPTTSLQFQKLGMLSPE-GTCKSFDASGDGYCRSEGVVAIYLQKQN-I--------------A--KR----IYS-TIVNSKTN--SDGSKEQ-------G---ITFPSGYVQKQLLNDVYSE-A-CIDP-ALVEYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQELNAIC-DVFC-K--D---R----------------------------------------------------------------S----T-PLLIGSIKSN-MGHPEPASGLAAVTKLIIGMEDKQMPANLH-Y---E--S--PNTDIPGLTDGRLEVVT--ERT-PLNG-----------GLVAVNSFG-FGGSNVHAVLKP--NVD--R--D-------------TNA--CD-L-------------------------S------KRLFLYSSRTKQGLEKIL-------------------- 529 ------------------------VAIIGIACRFP-G-A---EDTDEYMKNLK-EGKCFI-DEV-PK--E-RW-DSSQ--ADV----RDSDESWKN-RSKYAALI-----N-E--HD-KWDNKCFGISDS-EAAWMNPQQCLALEVTYSAIENAGITL--------DQIKG--TKTGVFI---------------------------------------G-AMNDDF--LLGL-P------------N----S-RH-ELNNFVATGMAPSLTSNRISYHFDLRGPS------LTLDTACSSALVAVHLGCQSLRSGESETAICGGVNLILTP-LPFIPLSKAEMISPTGKSCAFSKDAD--------------------------------------------------------------------GYVRGEGCGIVILKNYK-KAVE----------------DGDRILS-LVA-TGCN--QDGHSNT-------P---ITAPSSIQQHALLEDIYTR-F-QIDP-ATIQYIEAHG-----------------------------------------------------------------------T-GTRI------G------DPIEVNALA-TFFT-KR---K-D---------------------------------------------------------------N-----K-SIPIGSVKTS-IGHLESSAGTAGLIKTILMMKSGIFVPYLN-FK-LE--N--ANPKIN-FENIPFRVIK--DLE-IWPT--S-A--D-GSRIACVNSFG-FGGTNCHAIIRQLN--------D------R-K---K-TC--QA-S-TS---TYAL-VC-FS--------AK------SLPALI-------------------------------K 530 --------------------------IVGIGCRFP-G-A---DSIDEFWRILI-NGEDHI-KEV-PN--E-RW-NVDE--IDY----TETDESWKN-SVKYAGLI-----D-E--FD-KWDNKFFGIGDN-EAGWINPQTCLTLEVTHSALENGGFTM--------QNMKG--SNTGVYI---------------------------------------G-VTNNDM--MCGA-A------------S----C-RS-ESNSTMVTGINSSLTANRISNHYDLRGPS------LAVDTACSSSMTAVYMGCQAIRSGECDMAICGGVNSILSP-GIFIVLAKAKMTSPSGKSHPFADDVE--------------------------------------------------------------------GYVRGEGCGVIVLKKLN-QALT----------------DKDKIWG-TIA-CGCN--QNGKTST-------P---IIAPSSKQQRVLLEDVYRR-Y-KVDP-SIIQYVEAHG-----------------------------------------------------------------------A-GTPV------G------DPIEMRALS-EFFG-PY--FN-N---------------------------------------------------------------E-----P-TIAMGSVKSN-IGHLESAAAIAGLIKTLLMINHGRIVQSLH-YT-EK--S--GNSNID-FKNTALKVAT--STI-PWPV--R-P--D-GARYGSINSFG-FGGSNGHAIVKKFP----T---K------Y-F---N-ER--LD-P-VF---DYCM-IA-IS--------GT------SIPAVMKTLEHMKLKLGT------------DSYNVQDL 531 ------------------------VAIIGIACRFP-G-A---DDTDEFMKNLE-EGKCFI-DEV-PK--G-RW-NSNK--ADV----RDSDESWKD-RSKYAALI-----N-E--HD-KWDNKFFGVSDS-EAAWMNPQHCLALEVTHSAIENAGITL--------DQIKG--TKTGVFI---------------------------------------G-AMNDDF--LLGL-P------------S----S-RH-ELNNFVVTGMAPSITSNRISYQFDLQGPS------LTLDTACSSALVAVHLGCQSIRSGEIETAVCGGVNIILTP-LTFIPLSKAKMISPTGKSCAFSKDAD--------------------------------------------------------------------GYVRGEGCGIVILKNYK-KAVK----------------DGDRIWS-LIA-TGCN--QDGHSNT-------P---ITAPSSSQQQALLQDIYTK-F-RVDP-ASIQYIETHG-----------------------------------------------------------------------T-GTPV------G------DPIEVNALA-TFFA-PH--LN-D---------------------------------------------------------------E-----K-LIPIGSVKTN-IGHLESSAGTAGLIKTILMMKSGKFFPYLN-FK-PE--N--ANPKID-FGNIPFKVIQ--ASE-KWLS--S-D--D-GSRIACINSFG-FGGTNCHAIIRQLK----TD--D------R-Q---T-AC--KA-N-LS---AYIL-IC-FS--------AK------SLPALV-------------------------------K 532 ------------------------IAIIGIAFKGP-G-A---ENLEQLWEVLE-GGKNYV-LDLP-K--D-RW-NVDA--FYD----PDPQATGKY-YTRKAGLL-----S-N--PL-DFDNTFFDINDI-ESDQMDPQQKFVLECSYRAMEHAGITR--------RSIQG--SKTGVYI---------------------------------------G-AMNCDY--RGLF-PV-----------G----Y--S-VVSNYTVTGVSNSIIAARVSYAFDLRGPC------MVLDTGCSSALLAIHTASQALLNGDCTMAICGGTNFIGSP-DIFIHLSKAQMVSPTGQCHAFSEQAD--------------------------------------------------------------------GYTRGEGCGIVLLKKLS-D--------------Y--------------------------------------------------------------------EIEYIEAHG-----------------------------------------------------------------------T-GTQA------G------DYAEANALG-KFFK-KR---G----S------------------------------------------------------------S-----K-KRLIGSIKTN-IGHLESAAGVVGLIKVLLMMQHNKFVPSLF-SE-----S--LNKRID-FEALNLVVAS--QVK-DWTT--E-------NKVGSVNSFG-FGGSNCHAVVRSVV----QR--D-C------K---K-EE---------T---------------------------------------------T-------------------- 533 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGVYI---------------------------------------G-MMNDDY--KGGT-GT-----------D----L--K-TMNNYSLTGTSPSIASARVSYTYNLLGPS------ITLDTACSSALVAIHIGSQALKTGECNAVICGGVNSILYP-DIFVPLSKARMVSPTGQCQTFSDKAD--------------------------------------------------------------------GYARGEGCGIVILKTKK-Q--------------A--LLDGNKIWA-SIA-TACN--QDGRTMT-------P---ITAPSGLQQRNLLHKLYAD-K-GVNP-EDISYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEANTLG-KFFA-EK--Q--Q--GG----H---------------------------------------------------Y--R-----Q-NVFLGSVKTN-IGHLESAAGVAGLIKVLLMMDHGNIVPSLH-FK-N------PNPNIE-FEKYWLVVPH--NMT-SWPC--T-G--I--GRVACVNSFG-FGGTNSHAIIKQHH----YT--A------V-K---E-L--------KS------K-------------K-E------NHIVTISGSDITSLKNN--------------------L 534 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNDDY--KGGT-GT-----------D----L--K-TMNNYSLTGTSPSIASARVSYTYNLLGPS------ITLDTACSSALVAIHIGSQALKTGECNAVICGGVNSILYP-DIFVPLSKARMVSPTGQCQTFSDKAD--------------------------------------------------------------------GYARGEGCGIVILKTKK-Q--------------A--LLDGNKIWA-SIA-TACN--QDGRTMT-------P---ITAPSGLQQRNLLHKLYAD-K-GVNP-EDISYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEANTLG-KFFA-EK--Q--Q--GG----H---------------------------------------------------Y--R-----Q-NVFLGSVKTN-IGHLESAAGVAGLIKVLLMMDHGNIVPSLH-FK-N------PNPNIE-FEKYWLVVPH--NMT-SWPC--T-G--I--GRVACVNSFG-FGGTNSHAIIKQHH----YT--A------V-K---E-L--------KS------K-------------K-E------NHIVTISGSDITSLKNN--------------------L 535 ------------------------IYVAGIAARLPE--S---ENIDEFWENLM-VGKDMI-G-------QTRW-PKE---LYG--------------TPPRVGLIK------N--LD-KFDAEYFSFEE-TEVHHMNPMLRYLLEVSAECIVDSSLSL--------PVLQNN--TTGLYL---------------------------------------A-CFLPDN--DAL-ET---------------------SRG-ANSRLCTTVPTMAGHLMEHFGLSGPM------VTVDTGCSSSLSAMEMAVSDLRAGKCQFALVSSVNLLLNP-SYLQQMSQLGMLNPTGQSNVFDAKAG--------------------------------------------------------------------GYVRAEGVVTTLLTRNE-N---------------ICKH----VYLS-IVDILTN--CDGFKSE-------G---ITFPNSQSQANLMRTIYN-R-CKLDV-NKIAYVEAHS-----------------------------------------------------------------------T-GTKA------G------DPVEVAGIC-EAFC-KD--R------------------------------------------------------------------D-----T-PLLIGSVKAN-MGHSEATAGLASFVKCVLIARHGMIPPQIN-FN-----S--PNPNIDGITQGKVRVVD--KAT-PLED----G-------FISLNSFG-YGGANGHVVLKPYK----K---K-Q------S---N-R--------DI----------------------H------HSLIAIKARSEKEM---E-------------------- 536 ------------------------IVISGXLLSTP-Q-S--D-NVEEFHXNMM-NGTDMV-VH---TSS--SA-SDSD------------Y-G--T-TQPFSGTIR--------DLTK-FDAGFFGVPPK-LANVMDPQLRMLLEVTYETFVDAGIST--------EAMRGS--DTAVFI---------------------------------------G-CGLSEA--LEAY-VS---D------------P--E-HVNAYAPIGCSSSMLANRISYAFDLKVDNKSLQSK--------------------------------------------------------------------LCPENGSGSGFLALERAVTSVRQGLCGAAVVGACNLCLKAAASFQLMMLDLLSPD-GKCCCCDEDSCGTNRSEGVVVMLIQKRS-S--------------A--RR----IYS-TIRHIKCT--SMK-----------N---TYYPSYDEETKLLKEVYAE-T-GIDP-TQVNYVEVNG-----------------------------------------------------------------------S-CNVV------------ADAQEVNSIA-DVFC-R--N---R----------------------------------------------------------------D----X-PLMIGSVKTN-VGNTETASGLVSIVKVLTAAQEGMVPANLH-V---R--S--PNPSIPALHDGRIDYLS--ERK-RWTP-----------GIVGINSNG-LGHLHGHCI---------------------------------------------------------------------------------------------------------- 537 ------------------------VYLVGIAGRFP-NA----NNVEELWEQLKVYGESGI-TG-Q-S--PARWPNT-C--L-------------PY-LPKSVGRIK------N--ED-GFDADFWYFSDT-KTFSGNPILRHLLEVIYEAVLDSGLPL--------STFQSSSEPAGLYIA----------------------------------------QSSY-LDSVLT---S----------------K-QF-----KTFWEARSSNVPSHISHLLGTYGPS------VGVDADTNSSLVAVDIAVRDLQRGAVHYAIVAGGNLVVNP-LVAQGLEYLSLGSDGLSCGS-----------------------------------------------------------------------------QSDGVAAIILTREMLR--------------C--NR----IYSLLLG-VGISSD--GSRES-------G---TSHIDCNSMVKLIKETCRN-S-GVDL-EDILYIESSG------------------------------------------------------------------------P------GVQAV------DEEQMKRLVKTLLK-GK--K--I---------------------------------------------------------------D-----K-EVICAASTNA-IGHCQSAAGLVSIIVSVFAMHCDWVP---H-C---------FTSRITDLLDTTYHASD--APAEAVKDGHT---SI-KDGATVVISRG-LGGTSGCVVLV-------------------------------------------------------------------------------------------------------- 538 ---------------------------------------------------------------------------------------------------------------------------------------MDPQQSLLLECTYRALENGGIT----------HISG--TNTGVFV---------------------------------------G-AMTSDH--AVFY-PA-----------G----S--P-EVDSYTATGVSSSMLAARVSYVYNLLGPS------MVIDTACSSSLVAIHQGIQAIKNGDCGMAICGGVNYIGAP-TMFVQLSKTKMLSPTGQSRAFSADAD--------------------------------------------------------------------GYVRGEGCGIVVLKRLK-D--------------A--LDNNDHIWA-TVV-SGVN--QDGHTVT-------P---VTAPSGTQQEKLMTDIYTK-Y-GVDV-SRLDYIEAHG-----------------------------------------------------------------------T-GTQA------G------DPVEVNAIG-KFLK-AM---G----Q------------------------------------------------------------P-----R-TRYIGSVKTN-IGHLEAGAGVIGVIKVLLMMKHNTIVPSLH-C---K--K--VNPLID-LENLGLIVPQ--SLV-EWES--K-------DKMACCNSFG-FGGTNSHVVLQTFH----KE--K-N----------L------V-I-E---------------T-----R-S------SNVVCFSGKTKQS----L-------------------- 539 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CSSSLVAIHQGIQAIKNGDCDMAICGGVNYIGAP-TIFVQLSKTKMLSPTGQSRAFSADAD--------------------------------------------------------------------GYVRGEGCGIVVLKSLK-D--------------A--LHNNDRIWA-TVV-SGVN--QDGHTVT-------P---VTAPSGTQQEKLMTDIYTK-Y-GVDV-SRLDYIEAHG-----------------------------------------------------------------------T-GTQA------G------DPVEVNAIG-KFLK-AM---G----Q------------------------------------------------------------P-----R-TRYIGSVKTN-IGHLEAGAGVIGVIKVLLMMKHNTIVPSLH-C---K--K--VNPLID-LENLGLIVPQ--SLV-EWES--K-------DKMACCNSFG-FGGTNSHVVLQT------------------------------------------------------------------------------------------------------- 540 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFVQLSKAKMLSPTGQSRAFSADAD--------------------------------------------------------------------GYVRGEGCGIVVMKRLK-D--------------A--LDNNDHIWA-TVV-SGVN--QDGHTVT-------P---VTAPSGTQQEKLMTDIYTK-Y-GVDV-SRLDYIEAHG-----------------------------------------------------------------------T-GTQA------G------DPVEVNAIG-KFLK-AM---G----Q------------------------------------------------------------P-----R-TRYIGSVKTN-IGHLEAGAGVIGVIKVLLMMKHNTIVPSLH-C---K--K--VNPLID-LENLGLIVPQ--SLV-EWES--K-------DKMACCNSFG-FGGTNSHVVLQTF------------------------------------------------------------------------------------------------------ 541 ------------------------IAIVGIGCRLP-G-A---NNIREFWDVLV-NGENHV-KEIP-K--D-RW-NLDA--IYD----PDPDAYGKT-NVRRAGLL-----S-E--HD-VWDNELFGIPEK-EASEMDPQQRYVLECVHMALENGGITK--------AELGG--SSTSVYI---------------------------------------G-AMNSDA--KSSK-DG-----------D----Y--S-LMTNYTVTGDAASIIAARVSYNYNLLGPS------LTIDTACSSSLVAINLATQSLIIGESSMAICGGVNSILYP-DMFVTLTKARMASPTGQCQAFSANAD--------------------------------------------------------------------GYARGEGCGIVIPERLS-D--------------A--LKNDRHIWA-TIR-TGCN--QDGQTAK-------P---ITAPSEVQQGKLLNDIYHHFY-NINP-SHVQYIEAHG-----------------------------------------------------------------------T-GTPI------G------DPVEVNSLG-SFFK-DH--PTQF---G-------------------------------------------------------------------KRLIGSVKTN-IGHLESAAGAASLIKTLLMMKHGKIVPSLH-SI-----P--RNSKID-FEYYTLDVPA--SVH-AWPL--L-Q--D-GSRAACINCFG-FGGTNSHAFVRQWV----QK--P------I-D---P-T------------------PS-IADE-----D-K------LTCIPISAKSQNS------------------------L 542 ------------------------IAIVGIGCRFP-G-A---NNIREFWNVLV-NGENHV-KDIP-K--D-RW-NVDA--IYD----PDPDAYGKT-DVRRAGLL-----S-K--HD-VWDNEFFEISEK-EASEMDPQQRYVLECTHMALEDGGITK--------ADLDG--SPTSVYI---------------------------------------G-AMNSDA--KSAK-DG-----------D----Y--S-LLTNYTVTGDATSIISARVSFNYNLLGPS------LTIDTACSSSLVAINLATQSLIIGESSMAICGGVNSILYP-DMFVTLTKARMASPTGQCQAFSANAD--------------------------------------------------------------------GYARGEGCGIVILERLS-D--------------A--LENNRHIWA-TIR-TGCN--QDGKTAK-------P---ITAPSEVQQRKLLSDIYHHSY-NIDP-SHVQYIEAHG-----------------------------------------------------------------------T-GTPI------G------DPVEVNSLG-RFFK-DH--PILY---G-------------------------------------------------------------------QRFIGSVKTN-IGHLESGAGVASLIKTLLMMKHQKIVPSLH-SL-----P--RNPKID-FVGYALDVPA--SVY-RWPA--L-Q--D-GSRAACINCFG-FGGTNSHAFVRQWI----EI--P------D-K---S-R------------------SR-SENA-----E-K------MICVPVSAKSQ--------------------------I 543 ------------------------FAIVGVGCKFP-G-A---DNLDEFWRVLL-NGENHV-IEIP-P--E-RW-NVDA--FYN----EDPMEPGKT-NVRRAGFI-----R-K--YD-MWDNKLFGVSQV-ETARIDPQQRYVLDCVHMAMEDGGITR--------EDLNE--TDTGVYI---------------------------------------G-AMNDDY--RESA-ND-----------E----L--T-AMTNYTLTGSSLSIIAARVSYIYNLLGPS------MCIDTACSSSLVAIHLAIQAIKSGDCKAAICGGVNSILYP-HIFVPLSKARMVSATGQCQAFSDTAD--------------------------------------------------------------------GYARGEGCGMVIIKSLK-Q--------------A--KLDGNKIWS-VIV-TGCN--QDGHTAT-------P---ITAPSGRQQSALLERVYHD-Y-KVDP-KTIQYVEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEANSLG-SFFS-KG--K--H--IP----E---------------------------------------------------G--E-----T-DVRIGSVKTN-IGHLESAAGIAGLIKVMLMMHHGKVVPSLH-YR-K------SNPKID-FGSFSFEVAT--SIT-DWDT--L-P--D-GTRMSCVNSFG-FGGTNSHAIIKQIP----NT--E------V------------------------------------------------------------------------------------K 544 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSPTGQCQAFSDKAD--------------------------------------------------------------------GYARGEGCGIVMLKTKR-Q--------------A--LIDGNKIWA-AIA-TGCN--QDGRTTT-------P---ITAPSSVQQRNLLVKVYSE-T-GINP-KDIQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIETNTLG-QFFA-NK--LP-D--DD----N---------------------------------------------------H--L-----D-SILLGSVKTN-IGHLESAAGAAGLIKVLLMMTQGKIVPSLH-FE-N------PNPNID-FDSYRLEVAR--KMS-PWPC--H-K--Q-GGRLSCVNSFG-FGGTNSHAVIKQY------------------------------------------------------------------------------------------------------ 545 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTNRSEGVVIMLIQKRK-S--------------A--KR----IYS-TIRHIKCT--SMK-----------N---SFYPSYEEETKLLNEVYKQ-A-DVDP-TKVSYVEISG-----------------------------------------------------------------------S-CNVD------------ADAQEVNSVA-DICC-K--D---R----------------------------------------------------------------E----K-PLRIGSVKTN-VGNTETASGLVSILKVLMAAQEGMIPSNLH-V---G--T--PNQCIEALHDGRIEFLS--ERK-RWTP-----------GIVGVSCNG-MGHMHGHCIL--------------------------------------------------------------------------------------------------------- 546 ------------------------IAIVGIGCRFP-G-A---DNIDEFWRVLS-RGENHV-NEIP-L--E-RW-NLEA--FYD----KDADAPGKM-YVRKAGLL-----D-K--FD-EFDNKLFGISDK-EAERMDPQQRYVLECVFMALQDGGITR--------ESIQG--SDTGVFI---------------------------------------G-VMNDDY--SRLS-SN-----------G----D-----FNNYSLTGGSTSIISARVSYTFDLRGPC------MVIDTACSSSLLAIHLGSQALMSGDCKMVVCGGVNSLLTP-RTFIQLSKARMVSPTGQCQAFSANAD--------------------------------------------------------------------GYARGEGCGIVLLKRLS-D--------------A--ITDGDKIWA-TIV-TGTN--QDGRAVT-------P---MSAPSGEQQEKLLKTVYKK-A-GVDA-SDIDYIEAHG-----------------------------------------------------------------------T-GTKA------G------DPVEVQSLG-KFFL-----DT-Q--V------------------------------------------------------------------KKKRFIGSVKTN-IGHLESAAGVAGVIKVLLMMKNEKIVKSLL-MG-----E--KNPDID-FQKFSFEVPT--ELT-DWDT---------SRKLACINSFG-FGGSNCHVVLASNT----E---M-T----N-----D-TM--EN-N-KS--NAP-------------------------LLFCFSGQDGEGLK--K-------------------- 547 ------------------------IVISGISCRLP-E-S--D-NMEEFREHLV-LSEDMV-TE---DNR--RW-EPGY--------------L--G-LPSRNGKLK--------DISK-FDAQFFGVHPK-QADSMDPQLRILLEVAYEAIVDSGLNP--------QTIKGT--NTGVFI---------------------------------------G-VSSSEA--GEAW-SA---D------------P--E-KVVGYSMTGCCRAMFPNRLSYFFDFKGP------S--------------------------------------------------------------------YAIDTACSSSLLALDQAVMSIRLGKCDAAIVGGSNLCLKPTTALQFLKLGMLSPD-GACKSFDAAGNGYCRSEAIVAIYIQKTS-V--------------A--KR----VYS-TIVHSKNN--SDGAKEQ-------G---ITFPSGEIQKRLLHAVYAD-A-GIPP-SQVAYVEAHG-----------------------------------------------------------------------T-GTAV------------GDPQEVNSIV-DVFC-K--N---R----------------------------------------------------------------K----G-PLLIGSVKSN-IGHPEPASGLASIAKVIIAMEDGMIPPNLH-F---K--S--ANPDIPGLHNGQLEVVT--KCT-RWNG-----------GYIGVNSFG-FGGANVHAILRSH----DQD--G-P-----------LYE--AS-E-------------------------A------ER---------------L-------------------- 548 ------------------------IAVVGVGCRFP-G-A---DNIEEFWRVLS-NGENHV-NEIP-R--K-RW-NLEA--FYD----DDADAPGKM-YTRRAGLV-----E-N--FD-QFDNKLFSISEK-EAERMDPQQKFILECVFMALQDGGITR--------QNVQG--SNTGVYI---------------------------------------G-VMNDDY--SRLT-SK-----------T----D-----LNHYSVTGGSTSIMSARVSYTFDLRGPC------MSVDTACSSSLVAIHQAILALKSGDCNMAVCGGVNALLTP-SIFIQLSRARMLSRTGQCQTFSARAD--------------------------------------------------------------------GYARGEGCGIVLLKRLS-D--------------A--IKDGDNIWA-TIV-TGTN--QDGRTVS-------P---MTAPSGEQQEQLLKTVYEK-A-GIDA-SEIDYIEAHG-----------------------------------------------------------------------T-GTVA------G------DPVEVKSLG-KFFM-NL--HT-Q--V------------------------------------------------------------------QKKRYIGSVKTN-IGHLESAAGVAGLIKVLLMMKNNKIVKSIL-VD-----N--QHPDID-FQKFCFEIPG--DLK-DWDR---------KRKLACVNSFA-FGGTNCHAILSSYG----D---I-A----T-----E-IT--EE-H-VS--KVP-------------------------LMFCFSGQDQNGLM--E-------------------- 549 --------------------------VSGMACRFPK--S---ANVNEFWENLL-NGVDML-D-------SNVW-PDG---LYG--------------LPPRTGHIP------D--TDK-FDAKFFNIPE-SEAQHLSVVCRLLLEVIHECIVDSGLTF--------SDIEAA--KTGFYL---------------------------------------A-CTFSDV--DEV-TT---------------------SLM-ADSCWLNVKSEIVSQLSQMFGFDGPV------ISVDTACSSAFAAIDVAIGDLITGRCKYAIVAGINLVISP-NVSLRFHRLGMLSPTGDSHVYDQSAD--------------------------------------------------------------------GYVRSDGVAVIFLSQAE-S---------------ACKR----IYAS-LIDIAIS--CDGYKEE-------G---VLYPSHFAQSSLLKLIYS-R-NGVKN-KDISYIEMHG-----------------------------------------------------------------------T-GTQA------G------DLIETSALA-DVLC-QE--R------------------------------------------------------------------D-----E-PLFVGSVKSN-MGHCEATSGLAGLIKCILSMHHGVVPACLH-YK-----T--ANPNIEAICSGQVCVVT--EPL-SLTG----G-------LIGVSCFG-FGGVNGHALLQPYR----HN--V-P------D---N----------------------------------------------------------K-------------------- 550 ------------------------IAIVGIGCRMP-GNV---NGTEDFWDVLT-NGRNVI-GDIP-P--D-RW-SMDA--YHN----PDPSSLGTH-VNKKSGFID------G--ID-QFDNGFFKISPK-EAAMMDPQQRHLLEVTQEAFDDAGILS--------ELLKE---NCGVYV---------------------------------------G-IGMMDY--PLML-GP---E------------S--Q-NFNAYAHTGVAHSVAANRLSFAFNLKGPS------VAVDTACAASMTALHFGCQALWNKECSVSLVAGSNVLLMP-EVTAGFSALSVLSPEGLSCPFDKDAK--------------------------------------------------------------------GYVRSEGFGAIIIKPLS-Q--------------A--LQDGDNIYC-TIVGSGIA--ANGTSP--------S---ITMPSCEAQVRLMESVYGQ-F-NIDP-QKLIYVEAHG-----------------------------------------------------------------------T-GTPV------------GDPIEAEAIG-TALA-QE--R------------------------------------------------------------------N-----S-PLRIGSAKSN-FGHMECCAGLVSIIKAALMIKKHQLCPSIN-YS-S------PIDSR--FDEWNIEVQQ--KVE-DFPP--G------RKHLIGVNNYG-FGGALAHAIIGDYS----IT--H-P------R---K-SG--QS-G-WK---FGQS-DT----K-----G-------KELLIPLSAKTEEA----L-------------------- 551 ------------------------IAIVGIGCRFP-G-A---DNIEEFWRVLS-KGENHV-KEIP-L--E-RW-NLEA--YYD----DDPDAPGKM-YVRRAGLV-----K-N--FD-QFDNKLFGINDK-EAEKMDPQQKFVLECVFMALQDGGITR--------ENIQG--SNAGVFI---------------------------------------G-VLNDDY--SRLI-SK-----------K----D-----FDHYSVTGGTNSIMSARVSYTFDLRGPC------MSVDTACSSALLAIHLGSQALKSGDCNMAVCGGVNAVLTP-SIFIQLTKARMLSPTGQCQAFSASAD--------------------------------------------------------------------GYARGEGCGVVLLKRLS-D--------------A--IKDGDKIWA-TIV-TGTN--QDGRTVS-------P---MTAPSGQQQEQLLKTVYQK-A-GIDA-SEIDYIEAHG-----------------------------------------------------------------------T-GTVA------G------DPVEVNSLG-RFFL-----AS-G--V------------------------------------------------------------------QKKRYIGSVKTN-IGHLESAAGVAGLIKVLLMMKNNKIVKSLL-TG-----E--KNPDID-FEKFSLEVPN--DLK-DWEK---------ESKLACVNSFG-FGGSNFHAVLSTYT----K---I-A----N-----T-TT--EE-I-MS--KMP-------------------------LLFCFSGQDQNGLK--E-------------------- 552 ------------------------IAIVGVGCRFP-G-A---DNIEEFWRVLS-KGENHV-NEIP-H--K-RW-NLEA--YYD----EDANAPGKM-YARRAGLL-----E-N--FD-QFDNKLFGISDK-EAERMDPQQKFVLECVFMALQDGGITR--------QNMQG--SDTGVFI---------------------------------------G-VMSDDY--SKLT-SK-----------T----D-----LNHYSVTGGSTSIMSARVSYIFDLRGPC------MSVDTACSSSLVAIHLGIQALKSGDCNMAVCGGVNALLTP-SIFIQLSRARMLSRTGQCQAFSASAD--------------------------------------------------------------------GYARGEGCGIVLLKRLS-D--------------A--IRDGDNIWA-TIV-TGTN--QDGRTVS-------P---MTAPSGEQQEQLLKTVYQK-A-GIDA-SDIDYIEAHG-----------------------------------------------------------------------T-GTVA------G------DPVEVKSLG-KFFT-DL--HK-K--V------------------------------------------------------------------QKKRYIGSVKTN-IGHLESAAGVAGLIKVLLMMKNNKIVKSLL-AD-----K--LHPDID-FQKLSFEIPT--DLK-DWDR---------QKKIACVNSFA-FGGTNCHAVLSSFD----D---V-T----K-----I-TE--EH-N-MS--KVP-------------------------LMFCFSGQDQKGL------------------------ 553 --------------------------------RFP-G-A---DNIEEFWRVLS-KGENHV-NEIP-R--K-RW-NLDA--YYD----DDADAPGKM-YTRRAGLL-----E-N--FD-QFDNKLFGISDK-EAERMDPQQKFVLECVFMALQDGGITR--------QNIQG--SDTGVFI---------------------------------------G-IMNDDY--SKLT-ST-----------T----D-----MNHYNGTGGATSIASARVSYIFDLRGPC------MSVDTACSSSLVAIHLGIQALKSGDCNMAVCGGVNALLTP-SIFIQMSRAMMLSRTGQCHAFSASAD--------------------------------------------------------------------GYARGEGCGIVLLKRLS-D--------------A--IKDGDNIWA-TIV-TGTN--QDGRTVS-------P---MTAPSGEQQEQLLKSVYEK-A-GIDA-REIDYIEAHG-----------------------------------------------------------------------T-GTIA------G------DPVEVNSLG-RFFV-NL--HT-K--V------------------------------------------------------------------QKKRYIGSVKTN-IGHLESAAGVAGLIKVLLMMKKNTIVKSVL-ED-----D--QHPDID-FQKFWFEIPA--DLK-DWDR---------KTKFACVNSFA-FGGTNCHAILSSCA----D---I-T----I-----D-IT--GE-H-IS--KV------------------------------------------P-------------------- 554 ----------------------------------------------------------------------------------------------------------------------------------------------------MAMEDGGITR--------KHISG--TKTGVYI---------------------------------------G-AMNDDY--KSLS-NL-----------D----H--D-EDTHYTITGMSTTIIAARVSYVYNLRGPC------MVVDTACSSSITAIHLASEAIRSGDCDMAICGGVNSLLCP-DLFITLSRAKILSQTGQCQTFCDSAD--------------------------------------------------------------------GYTRAEGCGIVIIKSLK-K--------------A--LQDKNKIWG-VVR-TGIN--QDGRSVQ-------P---ITTPSGEQHEELFTQVYSR-Y-DVNP-RNLQYIEAHG-----------------------------------------------------------------------T-GTRV------G------DPTEVNAFG-RFIS-KY--RN-E--SKISNLMKDDDHD----D----VINTPAQNGIFFKKRLNKDVEQNTHETEKNVD-PYKK--R-----E-KTLIGSVKTN-IGHSEAAAGMSGLIKVLLMMKNGSYVPSLH-IR-KDKSN--LNKNIK-LEEYGFDIAM--ETD-EWRT--N-E--F-GERICCVNSFG-FGGSNSHAIVIQIP----EQ--R-S----K-----C-PN--TT-E-SS---VW-------------------------FPVCVSAPKTDGLKSVL-------------------- 555 ------------------------VVISGVSCRLP-L-S--D-NMDEFKANLM-GGVDMV-TE---DDS--RW-KAGL--------------Y--G-LPKRSGKLK--------DLSK-FDASFFGVHPK-QANSMDPQLRILLELTYEAIVDAGVNP--------EDIKGS--RTGVFI---------------------------------------G-ASASES--HDAW-SM---E------------I--E-NTVGYAMTGCTRSMFANRLSYFFDFKGP------S--------------------------------------------------------------------YSIDTACSSSLMALDQALHGIRCGQCDAAIVGGTQLCLNPAIAMQFMKLGMLSPE-GMCKSFDTDGNGYCRSEGILAVYLQKHA-G--------------A--KR----IYC-TLVHSKTN--SDGNKQQ-------G---ITFPSGDIQRKLLKEVYSE-A-CIDP-TLVSYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEAIALC-DVFC-K--N---R----------------------------------------------------------------K----G-PLPIGSVKSN-LGHTEPASGLAAVAKVIVAMEEGTIPGNLH-Y---R--S--PNEDIPGLANGKLEVVD--HNM-KCDV-----------GLVGVNSFG-LGGSNVHTILRSN----KCA--E------K-C----LIE--GC-E-------------------------K------KRLFLYSSRSEEGLKETLQK------------------ 556 ------------------------VVISGVSCRLP-Q-S--D-NMEEFKENLL-GGVDMV-TE---DNS--RW-KPGL--------------Y--G-LPKRSGTLK--------DLSK-FDASFFGVHPK-QANSMDPQLRILLEVTYEAIIDAGVNP--------EDIRGS--KTGVFI---------------------------------------G-ASASES--HDAW-MK---E------------V--E-NTVGYAMTGCTRSMFANRLSYFFDLKGP------S--------------------------------------------------------------------YTIDSACSSSLLALDQALYNIRSGLCDAAIVGGAHLCLNPAVAIQFMKLGMLSPE-GMCKSFDTEGNGYCRSEGIIAVYLQKEP-R--------------A--KR----IYC-TLIHSKTN--SDGNKP--------G---ITFPSGDIQKKLLKEVYSE-A-CIDP-TQVSYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEANALC-DVFC-K--G---R----------------------------------------------------------------I----G-PLPIGSVKSN-MGHTEPASGLTAVAKVIVAMEEGTIPGNLH-Y---R--S--PNEDIPGLANGKLEVVD--HNK-KFDV-----------GLVGVNSFG-LGGSNVHTILQSN----RYD--E------K-C----VFE--GS-E-------------------------K------KKLFLYSSRSEKGLE----E------------------ 557 ------------------------VVISGISCRLP-M-S---NNMEELKNNLL-NGVDMV-QC---DKP--RM-NTEM--------------F--DLPQ--MGELK--------DLSK-FDAEFFGVPPA-QADKMDPSLRILLEVTYEAIADAGIDP--------MKMRGN--NTGVYV---------------------------------------G-TIPSQF--HFAL-ST---D------------M--D-SISGYEMTGSEQCMLANRLSYWFDFRGP------S--------------------------------------------------------------------VVLNTACSSSLVALDQALKDVRQGVCSSAIVAGVNVLCHPGISKQLYTLGMLSPT-GRCASFDENADGYCRSEGIVAIFIQKKD-A--------------A--RR----IYC-SIVHSKVN--NNGHTPE-------G---IIYPSKEAQCRLLSELYEE-A-NVDP-LNVEYIEAHA-----------------------------------------------------------------------T-GTQA------------GDRVEAESIA-EIFC-K--Q---R----------------------------------------------------------------S----N-QLKVGSVKSN-LGHTENASGLVSIAKVIIAMETRTIPRNLH-Y---S--K--PNQKIQELYNGKLEVVH--KNI-KLEG-----------DYIGINNFG-FGGTNAHLLLKGH--RI-AK--Q--------N----V----S----------------------------------------------------D-------------------- 558 ------------------------IAVIGIGCRFP-G-A---DNIDEFWRVLV-NGENHV-VDIP-P--E-RW-NNDA--FYS----ENRNEPGKL-YVKKAAFI-----N-R--HD-EWDNRLFGISDN-EAARVDPQQRYVLECVHMAMEDSGITR--------MQLQG--SETGVFI---------------------------------------G-AMNGDY--ASLS-DF-----------D----H--D-GDTNYSATGGSNTVISARVSYVYNLQGPS------MVIDTACSSSMTAIHLGCQAIRSGDCEMALCGGVSSILSP-GLFVTLCRAKMLSPTNQCQAFCDTAD--------------------------------------------------------------------GYVRGEGCGIVFLKSYK-K--------------A--IEDRNKIWG-ILK-TGVN--QDGQMAQ-------P---LTAPAGKQQEKLLRKIYTR-Y-NISP-LDLQYIECHG-----------------------------------------------------------------------T-GTPV------G------DPTEVNAFG-NFIK-T---------------------------------------------RQFLPNQK-------------------------DILIGSVKTN-IGHLESAAGMAALIKVLLMMEKGKFVPSLH-VR-KDKSN--INKKIM-FEGYGLDVSV--DVS-DWPP--N-A--D-GQRVCCVNSFG-FGGSNSHAVVIQKT----SN--Q-A----V-----T-TE--DL-S-NE---MK-------------------------VINI-SALDKTAL---K-------------------- 559 ------------------------IAIIGIGCRFP-G-A---DNVKEFWRVLS-NGENHV-KEVP-P--D-RW-KLDA--FYD----ADPNAPGKT-YVRTAGFV-----K-G--VE-EWDHRFFGINDM-EAKLVDPQQRLVLECVHMALEDGGITR--------KDIDG--SDTGVYI---------------------------------------G-SMTDDY--KGHV-MD-----------D----V--G-LSSAYSVTGTHSSIMSARVSYIYNLLGPS------LTLDTACSSSLVAIDLASQAILTGTCNMAVCGGVNVLLDP-QMFIALSKARMLSPSGQCKTFTNEAD--------------------------------------------------------------------GYARGEGCGIVILKKLK-H--------------A--IADGNKIWS-IIK-TGTN--QDGHMTT-------P---ITAPSGLQQERLIQQTYKR-Y-HVET-SKIQVIEAHG-----------------------------------------------------------------------T-GTRI------G------DPTEVSALG-AHFG-KK--G-HA---------------------------------------------------------------R-----S-PVFIGSVKTN-IGHLEASAGVAGLIKVLLMMENEMIVPSLW-YR-NH--N--ENPKLK-MSDHGFIVPT--KCM-KWSK--S-Q--S-EKRFACVNSFG-FGGTNAHAIVEEYQ----EM--A------P-S---K-S------------------NT-EQLH-----T-L------PYIVAVSAVDKPTLK----------------------E 560 ------------------------IAIVGIGCRFP-G-A---DNIDEYWRLLV-NGENHV-KDIP-L--E-RW-NNDA--FYS----EDKDEPGKH-YVKKAGFI-----S-K--HD-EWDNRLFQVSDN-EAIRIDPQQRYVLECTHMAMEDGGITR--------KDLQG--TSTGVYI---------------------------------------G-VMNDDY--KVIA-SS-----------D----H--S-DDTNYSATGMSTTIIASRVSFVYNLQGPC------MVIDTACSSSMIAIHLGCQAIRTGDCEMAVCGGVSSIISP-DTFIALCKARMMSATGQCQTFCDSAD--------------------------------------------------------------------GYARGEGCGVVILKSYK-K--------------A--LKDGNKIWG-ILK-TGSN--QDGRVSQ-------P---ITAPSGEQQEELLKKVYKQ-Y-GVNP-TSLQYIEAHG-----------------------------------------------------------------------T-GTPI------G------DPTEANALG-RFIA-SC--RE-Q--SQIVSHTNDRRPSSSDSG----NPSEIDTSDSEKEDTVGIDAEKSEGRSNPDRY-SAFS--D-----K-TIPIGSVKTN-IGHTESAAGVAALIKVLLMMKNGKIVPSLH-VK-KDKSN--LNKKIK-LDEYGLDIAL--DVV-DWLP--N-E--D-GDRICCVNSFG-FGGSNSHAIVVQNT----RM--P-Y----P-----T-IS--SP-L-TN---EMSA----------------------YKTVCLSSLDTTSLINTM-------------------- 561 ------------------------IAVIGMGCRVS-G-A---DNINEFWRVLV-NGENHI-TDIP-K--E-RW-NNDA--FYS----ENRDEPGKS-YVKKAGFI-----N-E--YD-KWDNKLYHISDS-EATRIDPQQRQVLDCTHMALEDAGITR--------KQLKG--TQTSVFI---------------------------------------G-AMNDDY--KNLI-YS-----------E----H--I-EDTNDSATGMSTTLIAARVSYVYDLRGPC------MVVDTACSSSMAAIHLGCQAIRSGECDMAICGGVSCMLTP-DQFITLCKAKMLSPSGQCQSFCDTAD--------------------------------------------------------------------GYGRGEGCGIVLLKSHK-K--------------A--LQEKNKIWG-IVK-TGGN--QDGQVAK-------P---ITAPSSEQQEELLKKVYSL-Y-NIDP-LRLQYIEAHG-----------------------------------------------------------------------T-GTPI------G------DRREINAIG-RFIQ-SH--R---------LKISNGQQ--N-------ETSYPHGNVGNESELHNLQHSFDIQNERNTLA-QSKS--K-----C-TILIGSVKSN-IGHLESAAGVAALIKVLLMMNKRTFVPSLH-VK-KDKSN--ISSMIT-LENAGLEICT--DVS-EWKP--D-T--N-GNRMCCVNCFG-FGGSNMHAI---------------------------------------------------------------------------------------------------------- 562 ------------------------ISVVGLGCKFP-G-A---NNKEQFWENLR-KGINSV-KVIP-N--D-RW-NNEH--FYD----PNADSPGKM-YTDKAGFL-----D-G--IE-NWDHQFHNFSEE-EAKYMDPQQKLVLDCTHMALEDAGITR--------EQLND--TNTGVII---------------------------------------G-CMTDDY--KTQV-MD-----------ND---G--T-ADSTYTVPGSHNSIISARVSYSLNLTGTS------MTIDTACSSSLVSLDLGCQALMLGRCDTVICGGVNVLLDP-SLFVALSKARMLSPSGQCKTFIAEAD--------------------------------------------------------------------GYARGEGCGILILKRLE-D--------------A--ERDGNKVWA-NIY-TGTN--QDGGNEK-------P---ITAPSKKQQKELLQDIYET-Y-QIDK-SCIQVIEAHG-----------------------------------------------------------------------T-GTEK------G------DPVEVNTLG-EFFS-SN--S-NE--SN----Q---------------------------------------------------R--N-----S-SAYIGSVKTN-VGHLEAAAGVAGLFKVLLMMNYRLIVPSLW-YT-KE--N--ENPELN-LSSYGFIVPT--TPL-SWDK--V-D--G-KGRMACVNSFG-FGGTNAHVIVEEHT----VN--R------H-E---M-VL--YR-R-VD---SVTF-SQ-KQYL--GTSI-F------PYIITLSATDDES------------------------L 563 ------------------------VAIIGIGCRFP-G-A---SCLREFWQVLV-NGENHV-VEIS-D--E-RW-IKDV--FYD----RDPHAPGKT-YANTAGFI-----K-N--YA-HFDFKLFGINEQ-EASQMDPQQRQVLECTFMALEDAGITR--------KQIEG--EKVGVFI---------------------------------------G-CMNNDF--TQLS-NN-----------H----A--H-LIDHHSVTGTGSSIVSNRVSFIFDLRGPS------MTIDTACSSSLVAIHQAGLAMKAGDCSMAICGGVNLLLNG-GVFIPLSKAQMLSPTGQCRAFSAKAD--------------------------------------------------------------------GYTRGEGCGIVIIKPLK-Q--------------A--MKDGDNIWG-TIA-TGLN--QDGHVSK-------P---LTAPSGEQQAQLIQDVYSK-H-GINP-ASIDYIEAHG-----------------------------------------------------------------------T-GTKI------G------DPVEVNAFG-HFFM-EQ--QQ-S--K------------------------------------------------------------T--------RYIGSVKTN-IGHLESAAGVAGLIKVLLMMKHNTIVPSLH-FD-NP------NEEIN-FDMFKFQVSL--ARL-WESW--G-------VKPAAVVGQS-VGEVAAAHIAGILS----L---------------------------------------------------------------------------G-------------------- 564 ------------------------IAIIGVGCRFP-G-A---SCLGEFWDVLV-KGENHV-IEIP-P--D-RW-NRDT--FYD----PDVNANGKF-YSKKAGFI-----Q-N--YA-HFDNKLFGINES-EAAQMDPQQRQVLECTFMALEDAGVTR--------QQVAG--QKVGVYI---------------------------------------G-AMNSDF--TVRM-TA-----------N----S--H-EIDHYSVAGLAGSVLANRVSYVYNLSGPS------MVLDTACSSSLVAIHQAGLALRAGDCEMALCGGVNLLLHP-TVFVPLSKAQMLSPSGQCHAFSSNAD--------------------------------------------------------------------GYTRGEGCGIVLLKPLA-Q--------------A--LRDGDNIWA-TVS-TGVN--QDGRAAQ-------P---ITAPSGGQQLQLLQDLYRA-Y-CVDP-HTVEYIEAHG-----------------------------------------------------------------------T-GTKL------G------DPIEVNTFG-EFFS-SP--GN-Q--R------------------------------------------------------------K--------RYMGSVKTN-IGHLEPAAGVAGLIKVLLMMKYNTIVPSLH-FD-KP------NEHID-FDKFQFIIPQ--HPL-QWTS--V-------SKVACLNSFG-FGGTNSHAILHNYN----KP--P-Y------A---S-R----S-N-----------------L-----R-S------SHIVCFSGSSLETLK--K-------------------- 565 ------------------------IAIVGIGCRFP-G-A---SCLGEFWDILA-KGENHV-VDIP-P--E-RW-NKDA--FYD----SDVNAATNS-RTE---------------------------------------------------------------------------SEVYI---------------------------------------G-SMTTDY--GDLI-SN-----------K----S--Q-DVTNHTVTGQASSIISNRVSYVYNLTGPS------MTIDTACSSSIVALHQAGLALRAGDCSVAICGGVNLLIHP-GYFIKLSKAQMLSPTGQCHAFSANAD--------------------------------------------------------------------GYTRGEGCGIIIVKLLS-Q--------------A--LHDGDKIWG-TIV-TGLN--QDGRQVT-------P---ITAPSGKQQQELLNDIYTR-H-GIDP-TEVDYIEAHG-----------------------------------------------------------------------T-GTKR------G------DPVEASALG-TFFE-KY--PR-Q------------------------------------------------------------------------RHIGSVKTN-IGHLEAAAGVAGLIKVLLMMKHSTIVSSLH-FD-KP------NEAID-FDRFQFVVPT--ENT-DWKR--H-------KKIACINSFG-FGGSNSHAVLTSFT----ME--T-P------V---M-N----D-I--------------------------------ALPVCFSGSSEKT----L-------------------- 566 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLSPTGQCHSFSANAD--------------------------------------------------------------------GYTRGEGCGIIIVKLLS-Q--------------A--LHDGDNIWG-TIV-TGLN--QDGRQVT-------P---ITAPSGKQQQELLNDMYTR-H-GIDP-TEVDYIEAHG-----------------------------------------------------------------------T-GTKR------G------DPVEASALG-TFFE-KY--PR-Q------------------------------------------------------------------------RHIGSVKTN-IGHLEAAAGVAGLIKVLLMMKHDTIVPSLH-FD-KP------NEEID-FDRFQFVVPT--KNS-DWKR--H-------KKIACVNSFG-FGGSNSHAVLTSF------------------------------------------------------------------------------------------------------ 567 --------------------------ISGVSCRFPK--S---NNVQEFWQNLI-DGVDML-G-------PSRW-PPG---LYG--------------LPPRAGSIP------D--LGT-FDAEFFGYSE-TEARHSNLLLRLLFEVTYESVVDSGLTL--------SSLRSD--RTGLYV---------------------------------------A-CTFSDA--DAI-TT---------------------SAV-TDSVHANLRSTLLQQLNAWYRFQGPV------ASVDTACSSSVSALQMAVTDLITGRCNYAVVTGVNLILSP-NCSQSFNRLGMLSPTGDSHVFDISAN--------------------------------------------------------------------GYVRSDGVAVLILARNP-E---------------RCER----IYAT-IADIAVN--CDGYKVE-------G---IVYPSRSSQGNLLRSLYG-E-KLIPT-SSLAYVEAHG-----------------------------------------------------------------------T-GTQA------G------DCLELNAIL-DGLC-EG--R------------------------------------------------------------------D-----E-PLLVGSVKSN-MGHCEAASG---------------------------------------------------------------R----I-SIMGINSFG-FGGVNGHLILMSYK----NP--P-D------E---C-KK--A----G------------------------------TYLVPLTVRSEEGIARIRTFLEKHSENVALLK------ 568 ------------------------IAIIGIGCRFP-G-A---SCLREFWQVLV-NGENHV-VEIT-D--E-RW-NKDA--YYD----KDPRTPGKS-YAPRAGFI-----K-N--YA-HFNFKMFGMNEH-EAAQMDPQQRQVLECTYMALEDAGITR--------QQIAG--QKVGVFL---------------------------------------G-CMNNDF--TQLA-NK-----------H----P--H-LVDNFTVTGTGNSIVSNRVSYAFDLRGPS------MTIDTACSSSLVAIHQAGLAMKEGDCSMAICGGVNLLLSG-GVFVPLSKAQMLSPTGQCHAFSANAD--------------------------------------------------------------------GYTRGEGCGIVIIKPFK-Q--------------A--LEDGDNIWG-TLV-TGLN--QDGHVAK-------P---LTAPSGEQQAQLIQDVYTK-H-GIDP-ASIDYIEAHG-----------------------------------------------------------------------T-GTKI------G------DPVEVKAFG-HFFL-QQ--QQ-S--K------------------------------------------------------------R--------RYIGSVKTN-IGHLEAAAGVAGLIKVLLMMKHNTIVRSLH-FD-KP------NKDID-FDRYQFVVPV--ENV-DWKR--E-------KKIACINSFG-FGGSNSHAVLRSYS----VE--R-L------G---Q-C----N-E-----------------T-----D-E------IVPVCFSGFDYDTLH--K-------------------- 569 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAICGGVTLLLHP-SYFIKLCKARMLSPTGQCHAFSANAD--------------------------------------------------------------------GYTRGEGCGIVIVKLLS-Q--------------A--LHDGDNIWG-TIV-TGLN--QDGRQVT-------P---ITAPSGKQQQELLNDIYTR-H-GIDP-TEVDYIEAHG-----------------------------------------------------------------------T-GTRR------G------DPVEATALG-TFFE-KF--PR-Q------------------------------------------------------------------------RHIGSVKTN-IGHLEAAAGVAGLIKVLLMMKHNTIVRSLH-FD-KP------NKDID-FDRYQFVVPV--ENV-DWKR--E-------KKIACINSFG-FGGSNSHAVLRS------------------------------------------------------------------------------------------------------- 570 --------------------------VAGVAARLPE--S---ENIDEFWENLM-RSKDMT-R-------QTRW-PQG---LHG--------------TPPRMGQIK------N--ID-KFDAEYFSFEE-NEVHHMNPMLRHLLEVCSECIVDSGLCL--------PVLQGN--ITGLYL---------------------------------------S-CFLPDN--DSL-ET---------------------SRG-SISRLCTTVPMMAGHLMEHFGFSGPM------MSVDTGCSSSLSALDLAVGGLKTGKCQFAIVTAVNLLLNP-SYLQQMTQLGMLSPNGQTNVFDAKAG--------------------------------------------------------------------GYVRAEGVVSVLLTRNV-S---------------ICKH----VYVS-VVDILTN--CDGFKSE-------G---ITFPNSQSQAELMTTVYS-R-CGIDL-NRISFVEAHS-----------------------------------------------------------------------T-GTKA------G------DPIEVAGIC-EALC-KD--G------------------------------------------------------------------H-----K-PLLIGSVKAN-IGHSEATAGLASFVKCIMIARHGMIPPQIN-FH-----L--PNPQTDGIVQGKVRIVD--KPT-PLAD----G-------YIGLNSFG-YGGSNGHLVLKPYR----N---H-C------N---L-T--------GI----------------------P------HSLVTVKARNEAEM---E-------------------- 571 ------------------------IAIVGISCKFP-G-A---ENLDEFWRVIE-GGEDH-VKDIP-K--D-RY-DVEA--FYD----SDPDATGKS-YIRKAGLV-----S-G--IN-EWDNIFFEKGEN-EAKKMDPQQRLVLECVYKAMEDGGITK--------TKLNK--SETGVYI---------------------------------------G-VMNGEF--ETCL-RN-----------D----V--Q-FLSNYSVTGISRSIVSAQVSYFLNLHGPA------ITMDTACSSSLVAIHTAAQAIKAGEITAAICGGVNVLLSE-MTSIVLSKARMASPTGKCHTFSKNAD--------------------------------------------------------------------GYVRGEGCGIVILKRLG-D--------------A--IRENDKIWG-TIA-TACN--QDGHENS-------P---ITAPAESQQIHLLQRIFEN-S-KMHP-GSIQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIETNALG-KFFG-PH--FK-----------------------------------------------------------------D-----R-KVKIGSVKTN-IGHLESAAGVAGIIKVLLMMKHGHFVPSLH-AD-E------PNKNIP-FQEYGFTISR--DNS-KWKQ--N-S--H-GCRIASINSFG-FGGTNSHAIIYSNQ----SF--N------K-L---R-IN--VE-E-SN---SEVL-F-----------P-K------SKVVVFSAVTKGSLR----------------------K 572 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNGEF--ETCL-RN-----------D----V--Q-FLSNYSVTGISRSIVSAQVSYFLNLHGPA------ITMDTACSSSLVAIHTAAQAIKAGEITAAICGGVNVLLSE-MTSIVLSKARMASPTGKCHTFSKNAD--------------------------------------------------------------------GYVRGEGCGIVILKRLG-D--------------A--IRENDKIWG-TIA-TACN--QDGHENS-------P---ITAPAESQQIHLLQRIFEN-S-KMHP-GSIQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIETNALG-KFFG-PH--FK-----------------------------------------------------------------D-----R-KVKIGSVKTN-IGHLESAAGVAGIIKVLLMMKHGHFVPSLH-AD-E------PNKNIP-FQEYGFTISR--DNS-KWKQ--N-S--H-GCRIASINSFG-FGGTNSHAIIYSNQ----SF--N------K-L---R-IN--VE-E-SN---SEVL-F-----------P-K------SKVVVFSAVTKGS------------------------L 573 ------------------------LVISGVSCRLP-E-S--E-NMEEFEQHLM-NGDDMV-SE---DNR--RW-QPGL--------------Y--G-LPKRSGKLK--------TLNK-FDATFFGVNPK-QANRMDPQLRMLLEVTYEAIVDSGTDP--------SSIRDS--KTGVFI---------------------------------------G-ASASEA--HEAW-TM---D------------P--Q-KTVGYTLTGCSRSMIANRLSYFFDFKGP------S--------------------------------------------------------------------FVLDTYCSSSLLALDQAVNSIRQGHCDAAIVGGCSVCLKPLTALQCHQLGMLSPE-GTCKSFDASGNGYCRSEGIVVVYLQMKP-D--------------A--KR----IYS-RVVHSKTN--SDGKKEQ-------G---ITFPSGDIQKRLLDDVYED-A-GVAP-NKVVYVEAHG-----------------------------------------------------------------------T-GTKA------------GDPQEVNTIV-DVFC-K--D---R----------------------------------------------------------------E----G-PLPIGSVKSN-MGHSEPASGLAAIAKVIIGMEKGVIPANLH-F---K--E--PNPDIPGLNDGRLQVVT--RNT-PMKE-----------GFVGINSFG-FGGSNVHAILQTP--G--DQ--R-K------S----KHD--AS-T-------------------------L------KRLFVYSSRTYNGV---Q-------------------- 574 ------------------------IVISGISCRLS-G-SDSDVNVEEFKENLR-RERDMV-TH---RKN---T-EYTD------------Y-S--I-TRSCSGTIG--------DLTK-FDAGFFGIPPK-LANVLDPQLRMLLEVTYEAIVDGGIST--------EALRGS--DTAVFI---------------------------------------G-CGLSEA--LEAH-SS---D------------P--D-HVNAYGPVGSSSSMLANRISFAFDLKGP------S--------------------------------------------------------------------YALKNGNGTSFLALETAIMSIQEGKCETAIVGACNLCMKAAVFFQLMLLDVLSPD-GKCCYCDENSFGTNRSEGVVVMVIQKRR-S--------------A--KR----IYS-TISHLKCC--SMK-----------K---SYYPSYEEETKLLKEIYEE-A-NIDP-TEVGYIEISG-----------------------------------------------------------------------S-CDIE------------GDTQEVNSIV-DIFC-R--N---R----------------------------------------------------------------E----M-PLMIGSVKTN-LGNTETVSGLVSILKVLTAAQEEMMPANLH-V---P--S--LNQSIPAFQDGRINFLT--ERT-RWTP-----------GIVGINCYG-MGHLNGHCILDFN--R-NPS--G--------C----CTK--SK-E--------------------------------KRLAVF-----------S-------------------- 575 ---------------------F--FGKGDNEAKRM-D-P---QQRLVLECVYK-AMEDGGITKAN-L--D-RS-ETGV--YIG----EFLNSFGRA-MLSAKNAN-----K-D--YM-SVPQWCFNMFDF-T---IIYFFKTILVYDFDTKDICSGHS--------HNSPQ--IEVTSFI---------------------------------------G-AMNGEF--EAHF-IE-----------D----T--K-VLSHYSVTGLSRSVISAQVAYFLNLHGPA------LTLDTACSSSLVAIHAGAQAIRTGEINLAICGGVNVLMSH-MMPIVLSKARMASPTGKCHTFSKNAD--------------------------------------------------------------------GYVRGEGCGVVILKRLG-D--------------A--MRDNDKIWG-TIN-TACN--QDGHENS-------P---ITAPAESQQIRLLEKIFNK-S-GIDP-GSVQYIEAHG-----------------------------------------------------------------------T-GTPV------G------DPIEANALG-KFFG-SH--YV-----------------------------------------------------------------D-----R-KIKIGSVKTN-IGHLESAAGVAGLIKVLLMMKQGYFVPSLH-AD-E------QNENIP-FQEYGFTISK--DYS-KWNQ--G-P--E-GCRLASINSFG-FGGTNSHAIIYSSQ----SF--N------R-L---G-KS--NK-G-SM---SEIL-F-----------P-R------RNAVVLSAVTRDSLQ----------------------K