Supplementary Table 1: Prefrontal cortex cohort cell type composition Cell Type AD AD Total Control Control Total Total APOE3/3 APOE3/4 APOE3/3 APOE3/4 Astrocytes 859 352 1211 901 92 993 2204 Excitatory neurons 8198 3276 11474 9878 415 10293 21767 Inhibitory neurons 1708 998 2706 2838 208 3046 5752 Microglia 311 238 549 501 102 603 1152 Oligodendrocytes 4275 1459 5734 5290 292 5582 11316 Oligodendrocyte progenitor cells 562 275 837 760 43 803 1640 Total 15913 6598 22511 20168 1152 21320 43831 a